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bionlp-st-ge-2016-spacy-parsed

2_test

{"project":"2_test","denotations":[{"id":"23472114-8916932-87899169","span":{"begin":121,"end":123},"obj":"8916932"},{"id":"23472114-11001915-87899170","span":{"begin":224,"end":226},"obj":"11001915"},{"id":"23472114-7492756-87899171","span":{"begin":287,"end":288},"obj":"7492756"},{"id":"T82770","span":{"begin":121,"end":123},"obj":"8916932"},{"id":"T53126","span":{"begin":224,"end":226},"obj":"11001915"},{"id":"T12750","span":{"begin":287,"end":288},"obj":"7492756"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

pmc-enju-pas

bionlp-st-ge-2016-coref

{"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T1290","span":{"begin":4,"end":12},"obj":"Antecedent"},{"id":"T1289","span":{"begin":126,"end":128},"obj":"Anaphor"}],"relations":[{"id":"R820","pred":"boundBy","subj":"T1289","obj":"T1290"}],"namespaces":[{"prefix":"_base","uri":"https://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

bionlp-st-ge-2016-test-proteins

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T1310","span":{"begin":584,"end":588},"obj":"Protein"},{"id":"T1309","span":{"begin":386,"end":390},"obj":"Protein"},{"id":"T1308","span":{"begin":364,"end":384},"obj":"Protein"},{"id":"T1307","span":{"begin":4,"end":12},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

bionlp-st-ge-2016-uniprot

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T2110","span":{"begin":4,"end":12},"obj":"http://www.uniprot.org/uniprot/P05120"},{"id":"T2122","span":{"begin":584,"end":588},"obj":"http://www.uniprot.org/uniprot/O00206"},{"id":"T2121","span":{"begin":386,"end":390},"obj":"http://www.uniprot.org/uniprot/O00206"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

UBERON-AE

{"project":"UBERON-AE","denotations":[{"id":"T1202","span":{"begin":475,"end":482},"obj":"http://purl.obolibrary.org/obo/UBERON_0012131"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

GO-BP

{"project":"GO-BP","denotations":[{"id":"T1367","span":{"begin":673,"end":702},"obj":"http://purl.obolibrary.org/obo/GO_0032111"},{"id":"T1366","span":{"begin":765,"end":789},"obj":"http://purl.obolibrary.org/obo/GO_0030295"},{"id":"T1365","span":{"begin":673,"end":702},"obj":"http://purl.obolibrary.org/obo/GO_0030295"},{"id":"T1364","span":{"begin":765,"end":789},"obj":"http://purl.obolibrary.org/obo/GO_0032147"},{"id":"T1363","span":{"begin":673,"end":702},"obj":"http://purl.obolibrary.org/obo/GO_0032147"},{"id":"T1362","span":{"begin":765,"end":789},"obj":"http://purl.obolibrary.org/obo/GO_0034199"},{"id":"T1361","span":{"begin":673,"end":702},"obj":"http://purl.obolibrary.org/obo/GO_0034199"},{"id":"T1360","span":{"begin":295,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0002922"},{"id":"T1359","span":{"begin":295,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0002253"},{"id":"T1357","span":{"begin":339,"end":358},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T1355","span":{"begin":715,"end":722},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T1354","span":{"begin":339,"end":349},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T1343","span":{"begin":516,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T1342","span":{"begin":305,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0006955"},{"id":"T1339","span":{"begin":509,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0045824"},{"id":"T1337","span":{"begin":509,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0045089"},{"id":"T1335","span":{"begin":509,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0002218"},{"id":"T1333","span":{"begin":509,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0045088"},{"id":"T1331","span":{"begin":509,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0002227"},{"id":"T1329","span":{"begin":509,"end":532},"obj":"http://purl.obolibrary.org/obo/GO_0045087"},{"id":"T1369","span":{"begin":791,"end":795},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T1368","span":{"begin":765,"end":789},"obj":"http://purl.obolibrary.org/obo/GO_0032111"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

GO-MF

{"project":"GO-MF","denotations":[{"id":"T1384","span":{"begin":791,"end":795},"obj":"http://purl.obolibrary.org/obo/GO_0004707"},{"id":"T1383","span":{"begin":765,"end":789},"obj":"http://purl.obolibrary.org/obo/GO_0030295"},{"id":"T1382","span":{"begin":673,"end":702},"obj":"http://purl.obolibrary.org/obo/GO_0030295"},{"id":"T1381","span":{"begin":566,"end":580},"obj":"http://purl.obolibrary.org/obo/GO_0001530"},{"id":"T1379","span":{"begin":566,"end":573},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

GO-CC

{"project":"GO-CC","denotations":[{"id":"T1391","span":{"begin":43,"end":47},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

sentences

{"project":"sentences","denotations":[{"id":"T1216","span":{"begin":562,"end":849},"obj":"Sentence"},{"id":"T1215","span":{"begin":360,"end":561},"obj":"Sentence"},{"id":"T1214","span":{"begin":291,"end":359},"obj":"Sentence"},{"id":"T1213","span":{"begin":126,"end":290},"obj":"Sentence"},{"id":"T1212","span":{"begin":0,"end":125},"obj":"Sentence"},{"id":"T22","span":{"begin":0,"end":125},"obj":"Sentence"},{"id":"T23","span":{"begin":126,"end":290},"obj":"Sentence"},{"id":"T24","span":{"begin":291,"end":359},"obj":"Sentence"},{"id":"T25","span":{"begin":360,"end":561},"obj":"Sentence"},{"id":"T26","span":{"begin":562,"end":849},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

simple1

{"project":"simple1","denotations":[{"id":"T1408","span":{"begin":584,"end":588},"obj":"Protein"},{"id":"T1407","span":{"begin":386,"end":390},"obj":"Protein"},{"id":"T1406","span":{"begin":364,"end":384},"obj":"Protein"},{"id":"T1405","span":{"begin":4,"end":12},"obj":"Protein"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

BioNLP16_DUT

{"project":"BioNLP16_DUT","denotations":[{"id":"T2066","span":{"begin":584,"end":588},"obj":"Protein"},{"id":"T2065","span":{"begin":386,"end":390},"obj":"Protein"},{"id":"T2064","span":{"begin":364,"end":384},"obj":"Protein"},{"id":"T2063","span":{"begin":4,"end":12},"obj":"Protein"},{"id":"T2087","span":{"begin":619,"end":624},"obj":"Positive_regulation"},{"id":"T2086","span":{"begin":566,"end":573},"obj":"Binding"},{"id":"T2085","span":{"begin":28,"end":37},"obj":"Regulation"}],"relations":[{"id":"R1453","pred":"themeOf","subj":"T2063","obj":"T2085"},{"id":"R1454","pred":"themeOf","subj":"T2066","obj":"T2086"},{"id":"R1468","pred":"themeOf","subj":"T2086","obj":"T2087"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

BioNLP16_Messiy

{"project":"BioNLP16_Messiy","denotations":[{"id":"T2225","span":{"begin":584,"end":588},"obj":"Protein"},{"id":"T2224","span":{"begin":386,"end":390},"obj":"Protein"},{"id":"T2223","span":{"begin":364,"end":384},"obj":"Protein"},{"id":"T2222","span":{"begin":4,"end":12},"obj":"Protein"},{"id":"T2246","span":{"begin":619,"end":624},"obj":"Positive_regulation"},{"id":"T2245","span":{"begin":566,"end":573},"obj":"Binding"},{"id":"T2244","span":{"begin":28,"end":37},"obj":"Regulation"}],"relations":[{"id":"R1515","pred":"themeOf","subj":"T2225","obj":"T2245"},{"id":"R1542","pred":"themeOf","subj":"T2245","obj":"T2246"},{"id":"R1513","pred":"themeOf","subj":"T2222","obj":"T2244"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

DLUT931

{"project":"DLUT931","denotations":[{"id":"T2166","span":{"begin":619,"end":624},"obj":"Positive_regulation"},{"id":"T2165","span":{"begin":566,"end":573},"obj":"Binding"},{"id":"T2164","span":{"begin":28,"end":37},"obj":"Regulation"},{"id":"T2144","span":{"begin":584,"end":588},"obj":"Protein"},{"id":"T2143","span":{"begin":386,"end":390},"obj":"Protein"},{"id":"T2142","span":{"begin":364,"end":384},"obj":"Protein"},{"id":"T2141","span":{"begin":4,"end":12},"obj":"Protein"}],"relations":[{"id":"R1481","pred":"themeOf","subj":"T2141","obj":"T2164"},{"id":"R1482","pred":"themeOf","subj":"T2144","obj":"T2165"},{"id":"R1494","pred":"themeOf","subj":"T2165","obj":"T2166"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

bionlp-st-ge-2016-test-ihmc

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T2484","span":{"begin":491,"end":560},"obj":"Regulation"},{"id":"T2477","span":{"begin":757,"end":796},"obj":"Positive_regulation"},{"id":"T2474","span":{"begin":628,"end":664},"obj":"Binding"},{"id":"T2473","span":{"begin":562,"end":618},"obj":"Binding"},{"id":"T2467","span":{"begin":0,"end":118},"obj":"Regulation"},{"id":"T2466","span":{"begin":669,"end":702},"obj":"Positive_regulation"},{"id":"T2460","span":{"begin":581,"end":588},"obj":"Protein"},{"id":"T2459","span":{"begin":775,"end":796},"obj":"Protein"},{"id":"T2457","span":{"begin":604,"end":618},"obj":"Entity"},{"id":"T2451","span":{"begin":684,"end":702},"obj":"Protein"},{"id":"T2442","span":{"begin":386,"end":390},"obj":"Protein"},{"id":"T2440","span":{"begin":0,"end":17},"obj":"Protein"},{"id":"T2436","span":{"begin":139,"end":170},"obj":"Protein"},{"id":"T2435","span":{"begin":757,"end":764},"obj":"Entity"},{"id":"T2427","span":{"begin":214,"end":222},"obj":"Entity"},{"id":"T2426","span":{"begin":804,"end":834},"obj":"Entity"},{"id":"T2424","span":{"begin":823,"end":826},"obj":"Protein"},{"id":"T2421","span":{"begin":4,"end":12},"obj":"Protein"},{"id":"T2420","span":{"begin":90,"end":99},"obj":"Protein"},{"id":"T2413","span":{"begin":291,"end":294},"obj":"Entity"},{"id":"T2411","span":{"begin":43,"end":61},"obj":"Entity"},{"id":"T2408","span":{"begin":544,"end":552},"obj":"Protein"},{"id":"T2403","span":{"begin":644,"end":664},"obj":"Entity"},{"id":"T2398","span":{"begin":430,"end":433},"obj":"Entity"},{"id":"T2391","span":{"begin":804,"end":834},"obj":"Protein"},{"id":"T2388","span":{"begin":360,"end":391},"obj":"Protein"},{"id":"T2385","span":{"begin":574,"end":580},"obj":"Entity"},{"id":"T2378","span":{"begin":104,"end":113},"obj":"Protein"},{"id":"T2372","span":{"begin":749,"end":754},"obj":"Protein"},{"id":"T2370","span":{"begin":791,"end":795},"obj":"Protein"}],"relations":[{"id":"R1649","pred":"themeOf","subj":"T2459","obj":"T2477"},{"id":"R1651","pred":"themeOf","subj":"T2460","obj":"T2473"},{"id":"R1606","pred":"themeOf","subj":"T2385","obj":"T2473"},{"id":"R1611","pred":"themeOf","subj":"T2403","obj":"T2474"},{"id":"R1615","pred":"themeOf","subj":"T2408","obj":"T2484"},{"id":"R1634","pred":"causeOf","subj":"T2435","obj":"T2477"},{"id":"R1637","pred":"themeOf","subj":"T2440","obj":"T2467"},{"id":"R1644","pred":"themeOf","subj":"T2451","obj":"T2466"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

bionlp-st-ge-2016-test-tees

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T2284","span":{"begin":566,"end":573},"obj":"Binding"},{"id":"T2283","span":{"begin":791,"end":795},"obj":"Protein"},{"id":"T2282","span":{"begin":757,"end":789},"obj":"Protein"},{"id":"T2281","span":{"begin":749,"end":754},"obj":"Protein"},{"id":"T2280","span":{"begin":730,"end":747},"obj":"Protein"},{"id":"T2279","span":{"begin":584,"end":588},"obj":"Protein"},{"id":"T2278","span":{"begin":544,"end":560},"obj":"Protein"},{"id":"T2277","span":{"begin":4,"end":17},"obj":"Protein"}],"relations":[{"id":"R1543","pred":"themeOf","subj":"T2279","obj":"T2284"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

testone

{"project":"testone","denotations":[{"id":"T1124","span":{"begin":632,"end":643},"obj":"Binding"},{"id":"T1123","span":{"begin":566,"end":573},"obj":"Binding"},{"id":"T1122","span":{"begin":236,"end":248},"obj":"Positive_regulation"},{"id":"T1121","span":{"begin":188,"end":195},"obj":"Positive_regulation"},{"id":"T1105","span":{"begin":584,"end":588},"obj":"Protein"},{"id":"T1104","span":{"begin":386,"end":390},"obj":"Protein"},{"id":"T1103","span":{"begin":364,"end":384},"obj":"Protein"},{"id":"T1102","span":{"begin":4,"end":12},"obj":"Protein"}],"relations":[{"id":"R746","pred":"equivalentTo","subj":"T1104","obj":"T1103"},{"id":"R747","pred":"themeOf","subj":"T1105","obj":"T1123"},{"id":"R754","pred":"themeOf","subj":"T1121","obj":"T1122"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

test3

{"project":"test3","denotations":[{"id":"T1174","span":{"begin":584,"end":588},"obj":"Protein"},{"id":"T1173","span":{"begin":566,"end":573},"obj":"Binding"},{"id":"T1172","span":{"begin":386,"end":390},"obj":"Protein"},{"id":"T1171","span":{"begin":364,"end":384},"obj":"Protein"},{"id":"T1170","span":{"begin":188,"end":195},"obj":"Positive_regulation"},{"id":"T1169","span":{"begin":4,"end":12},"obj":"Protein"},{"id":"T1146","span":{"begin":584,"end":588},"obj":"Protein"},{"id":"T1145","span":{"begin":386,"end":390},"obj":"Protein"},{"id":"T1144","span":{"begin":364,"end":384},"obj":"Protein"},{"id":"T1143","span":{"begin":4,"end":12},"obj":"Protein"}],"relations":[{"id":"R757","pred":"equivalentTo","subj":"T1172","obj":"T1171"},{"id":"R758","pred":"themeOf","subj":"T1174","obj":"T1173"}],"text":"The SerpinB2 gene is highly regulated in a cell type specific manner analogous to that of cytokines and oncogenes [29]; [30]. It is one of the most responsive genes known [31], and can be induced over 1000-fold by LPS [31]–[32], and is up-regulated by a range of inflammatory mediators [9]. LPS activates immune responses through multiple signalling pathways. The toll-like receptor 4 (TLR4) is responsible for the recognition of LPS and other microbial products and plays a central role in the initiation of innate immune responses, including cytokine release. The binding of LPS to TLR4 on the surface of macrophages leads to the recruitment of adaptor molecules and the activation of protein kinases, generating signals to the nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK) and/or phosphoinositide 3(PI3)-kinase pathways [33]."}

PMC:3589482 / 3267-4116 JSONTXT

Annnotations TAB JSON ListView MergeView

PMC:3589482 / 3267-4116 JSON TXT