PMC:3586680 / 918-1077 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T78	70-73	Protein	denotes	p53
T77	27-31	Protein	denotes	WWOX
T58	70-73	Protein	denotes	p53
T57	27-31	Protein	denotes	WWOX

Id	Subject	Object	Predicate	Lexical cue
T36	70-73	Protein	denotes	p53
T35	27-31	Protein	denotes	WWOX

Id	Subject	Object	Predicate	Lexical cue
T496	85-95	Negative_regulation	denotes	deficiency
T495	70-73	Protein	denotes	p53
R248	T495	T496	themeOf	p53,deficiency

Id	Subject	Object	Predicate	Lexical cue
T729	158-159	.	denotes	.
T728	153-158	NN	denotes	death
T727	148-152	NN	denotes	cell
T726	144-147	NNP	denotes	GBM
T725	137-143	VB	denotes	induce
T724	133-136	CC	denotes	and
T723	122-132	NN	denotes	resistance
T722	118-121	NNP	denotes	TMZ
T721	109-117	VB	denotes	overcome
T720	106-108	TO	denotes	to
T719	99-105	VBN	denotes	needed
T718	96-98	VBZ	denotes	is
T717	85-95	NN	denotes	deficiency
T716	74-84	JJ	denotes	functional
T715	70-73	NN	denotes	p53
T713	58-63	NNS	denotes	drugs
T712	46-57	JJ	denotes	therapeutic
T711	43-45	IN	denotes	by
T710	32-42	NN	denotes	activation
T709	27-31	NNP	denotes	WWOX
T708	16-26	VBG	denotes	triggering
T707	11-15	IN	denotes	that
T706	3-10	VBP	denotes	propose
T705	0-2	PRP	denotes	We
T714	64-69	IN	denotes	under
R417	T705	T706	nsubj	We,propose
R418	T706	T706	ROOT	propose,propose
R419	T707	T719	mark	that,needed
R420	T708	T719	csubj	triggering,needed
R421	T709	T710	compound	WWOX,activation
R422	T710	T708	dobj	activation,triggering
R423	T711	T710	prep	by,activation
R424	T712	T713	amod	therapeutic,drugs
R425	T713	T711	pobj	drugs,by
R426	T715	T717	amod	p53,deficiency
R427	T716	T717	amod	functional,deficiency
R428	T717	T714	pobj	deficiency,under
R429	T718	T719	auxpass	is,needed
R430	T719	T706	ccomp	needed,propose
R431	T720	T721	aux	to,overcome
R432	T721	T719	advcl	overcome,needed
R433	T722	T723	compound	TMZ,resistance
R434	T723	T721	dobj	resistance,overcome
R435	T724	T721	cc	and,overcome
R436	T725	T721	conj	induce,overcome
R437	T726	T728	compound	GBM,death
R438	T727	T728	compound	cell,death
R439	T728	T725	dobj	death,induce
R440	T729	T706	punct	.,propose
R443	T714	T710	prep	under,activation

Id	Subject	Object	Predicate	Lexical cue
T548	27-42	Positive_regulation	denotes	WWOX activation
T545	27-31	Protein	denotes	WWOX
T544	118-121	Entity	denotes	TMZ
T542	46-63	Entity	denotes	therapeutic drugs
T536	70-73	Protein	denotes	p53
R264	T545	T548	themeOf	WWOX,WWOX activation

Id	Subject	Object	Predicate	Lexical cue
T424	16-26	Positive_regulation	denotes	triggering
T423	85-95	Negative_regulation	denotes	deficiency
T422	32-42	Positive_regulation	denotes	activation
T414	70-73	Protein	denotes	p53
T413	27-31	Protein	denotes	WWOX
R220	T413	T422	themeOf	WWOX,activation
R221	T414	T423	themeOf	p53,deficiency
R224	T422	T424	themeOf	activation,triggering
R225	T423	T424	causeOf	deficiency,triggering

Id	Subject	Object	Predicate	Lexical cue
T473	32-42	Positive_regulation	denotes	activation
T472	16-26	Positive_regulation	denotes	triggering
T471	85-95	Negative_regulation	denotes	deficiency
T464	70-73	Protein	denotes	p53
T463	27-31	Protein	denotes	WWOX
R234	T463	T473	themeOf	WWOX,activation
R235	T464	T471	themeOf	p53,deficiency
R238	T473	T472	themeOf	activation,triggering

Id	Subject	Object	Predicate	Lexical cue
T380	16-26	Positive_regulation	denotes	triggering
T379	32-42	Positive_regulation	denotes	activation
T378	85-95	Negative_regulation	denotes	deficiency
T372	70-73	Protein	denotes	p53
T371	27-31	Protein	denotes	WWOX
R208	T371	T379	themeOf	WWOX,activation
R209	T372	T378	themeOf	p53,deficiency
R211	T379	T380	themeOf	activation,triggering

Id	Subject	Object	Predicate	Lexical cue
T134	27-31	Protein	denotes	WWOX
T135	70-73	Protein	denotes	p53

Id	Subject	Object	Predicate	Lexical cue
T336	153-158	NN	denotes	death
T335	148-152	NN	denotes	cell
T334	144-147	NN	denotes	GBM
T333	137-143	VB	denotes	induce
T332	133-136	CC	denotes	and
T331	122-132	NN	denotes	resistance
T330	118-121	NN	denotes	TMZ
T329	109-117	VB	denotes	overcome
T328	106-108	TO	denotes	to
T327	99-105	VB	denotes	needed
T326	96-98	VB	denotes	is
T325	85-95	NN	denotes	deficiency
T324	74-84	JJ	denotes	functional
T323	70-73	NN	denotes	p53
T322	64-69	IN	denotes	under
T321	58-63	NN	denotes	drugs
T320	46-57	JJ	denotes	therapeutic
T319	43-45	IN	denotes	by
T318	32-42	NN	denotes	activation
T317	27-31	NN	denotes	WWOX
T316	16-26	VB	denotes	triggering
T315	11-15	IN	denotes	that
T314	3-10	VB	denotes	propose
T313	0-2	PRP	denotes	We
R179	T313	T314	arg1Of	We,propose
R180	T318	T316	arg1Of	activation,triggering
R181	T318	T317	arg1Of	activation,WWOX
R182	T318	T319	arg1Of	activation,by
R183	T318	T322	arg1Of	activation,under
R184	T318	T326	arg1Of	activation,is
R185	T318	T327	arg2Of	activation,needed
R186	T321	T319	arg2Of	drugs,by
R187	T321	T320	arg1Of	drugs,therapeutic
R188	T325	T322	arg2Of	deficiency,under
R189	T325	T323	arg1Of	deficiency,p53
R190	T325	T324	arg1Of	deficiency,functional
R191	T327	T314	arg2Of	needed,propose
R192	T327	T315	arg1Of	needed,that
R193	T327	T326	arg2Of	needed,is
R194	T327	T328	modOf	needed,to
R195	T329	T332	arg1Of	overcome,and
R196	T331	T329	arg2Of	resistance,overcome
R197	T331	T330	arg1Of	resistance,TMZ
R198	T332	T328	arg1Of	and,to
R199	T333	T332	arg2Of	induce,and
R200	T336	T333	arg2Of	death,induce
R201	T336	T334	arg1Of	death,GBM
R202	T336	T335	arg1Of	death,cell

Id	Subject	Object	Predicate	Lexical cue
T144	153-158	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T143	148-158	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death

Id	Subject	Object	Predicate	Lexical cue
T147	148-152	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell

Id	Subject	Object	Predicate	Lexical cue
T86	0-159	Sentence	denotes	We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.
T9	0-159	Sentence	denotes	We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.

Id	Subject	Object	Predicate	Lexical cue
T165	70-73	Protein	denotes	p53
T164	27-31	Protein	denotes	WWOX