PMC:3586680 / 751-1141 JSONTXT

{"project":"test3","denotations":[{"id":"T78","span":{"begin":237,"end":240},"obj":"Protein"},{"id":"T77","span":{"begin":194,"end":198},"obj":"Protein"},{"id":"T76","span":{"begin":161,"end":165},"obj":"Protein"},{"id":"T75","span":{"begin":108,"end":111},"obj":"Protein"},{"id":"T74","span":{"begin":42,"end":46},"obj":"Protein"},{"id":"T73","span":{"begin":34,"end":37},"obj":"Protein"},{"id":"T58","span":{"begin":237,"end":240},"obj":"Protein"},{"id":"T57","span":{"begin":194,"end":198},"obj":"Protein"},{"id":"T56","span":{"begin":161,"end":165},"obj":"Protein"},{"id":"T55","span":{"begin":108,"end":111},"obj":"Protein"},{"id":"T54","span":{"begin":42,"end":46},"obj":"Protein"},{"id":"T53","span":{"begin":34,"end":37},"obj":"Protein"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"testone","denotations":[{"id":"T36","span":{"begin":237,"end":240},"obj":"Protein"},{"id":"T35","span":{"begin":194,"end":198},"obj":"Protein"},{"id":"T34","span":{"begin":161,"end":165},"obj":"Protein"},{"id":"T33","span":{"begin":108,"end":111},"obj":"Protein"},{"id":"T32","span":{"begin":42,"end":46},"obj":"Protein"},{"id":"T31","span":{"begin":34,"end":37},"obj":"Protein"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T496","span":{"begin":252,"end":262},"obj":"Negative_regulation"},{"id":"T495","span":{"begin":237,"end":240},"obj":"Protein"},{"id":"T494","span":{"begin":126,"end":134},"obj":"Regulation"},{"id":"T493","span":{"begin":161,"end":165},"obj":"Protein"},{"id":"T492","span":{"begin":108,"end":111},"obj":"Protein"},{"id":"T491","span":{"begin":42,"end":46},"obj":"Protein"},{"id":"T490","span":{"begin":34,"end":37},"obj":"Protein"}],"relations":[{"id":"R246","pred":"causeOf","subj":"T492","obj":"T494"},{"id":"R247","pred":"themeOf","subj":"T493","obj":"T494"},{"id":"R248","pred":"themeOf","subj":"T495","obj":"T496"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T729","span":{"begin":325,"end":326},"obj":"."},{"id":"T728","span":{"begin":320,"end":325},"obj":"NN"},{"id":"T727","span":{"begin":315,"end":319},"obj":"NN"},{"id":"T726","span":{"begin":311,"end":314},"obj":"NNP"},{"id":"T725","span":{"begin":304,"end":310},"obj":"VB"},{"id":"T724","span":{"begin":300,"end":303},"obj":"CC"},{"id":"T723","span":{"begin":289,"end":299},"obj":"NN"},{"id":"T722","span":{"begin":285,"end":288},"obj":"NNP"},{"id":"T721","span":{"begin":276,"end":284},"obj":"VB"},{"id":"T720","span":{"begin":273,"end":275},"obj":"TO"},{"id":"T719","span":{"begin":266,"end":272},"obj":"VBN"},{"id":"T718","span":{"begin":263,"end":265},"obj":"VBZ"},{"id":"T717","span":{"begin":252,"end":262},"obj":"NN"},{"id":"T716","span":{"begin":241,"end":251},"obj":"JJ"},{"id":"T715","span":{"begin":237,"end":240},"obj":"NN"},{"id":"T713","span":{"begin":225,"end":230},"obj":"NNS"},{"id":"T712","span":{"begin":213,"end":224},"obj":"JJ"},{"id":"T711","span":{"begin":210,"end":212},"obj":"IN"},{"id":"T710","span":{"begin":199,"end":209},"obj":"NN"},{"id":"T709","span":{"begin":194,"end":198},"obj":"NNP"},{"id":"T708","span":{"begin":183,"end":193},"obj":"VBG"},{"id":"T707","span":{"begin":178,"end":182},"obj":"IN"},{"id":"T706","span":{"begin":170,"end":177},"obj":"VBP"},{"id":"T705","span":{"begin":167,"end":169},"obj":"PRP"},{"id":"T704","span":{"begin":165,"end":166},"obj":"."},{"id":"T703","span":{"begin":161,"end":165},"obj":"NNP"},{"id":"T702","span":{"begin":158,"end":160},"obj":"IN"},{"id":"T701","span":{"begin":149,"end":157},"obj":"NN"},{"id":"T700","span":{"begin":139,"end":148},"obj":"JJ"},{"id":"T699","span":{"begin":135,"end":138},"obj":"DT"},{"id":"T698","span":{"begin":126,"end":134},"obj":"VBP"},{"id":"T697","span":{"begin":124,"end":125},"obj":","},{"id":"T696","span":{"begin":116,"end":124},"obj":"NNS"},{"id":"T695","span":{"begin":113,"end":115},"obj":"CC"},{"id":"T694","span":{"begin":111,"end":112},"obj":","},{"id":"T693","span":{"begin":108,"end":111},"obj":"NN"},{"id":"T692","span":{"begin":101,"end":107},"obj":"JJ"},{"id":"T691","span":{"begin":97,"end":100},"obj":"CC"},{"id":"T690","span":{"begin":92,"end":96},"obj":"NN"},{"id":"T689","span":{"begin":87,"end":91},"obj":"JJ"},{"id":"T688","span":{"begin":82,"end":86},"obj":"WDT"},{"id":"T687","span":{"begin":72,"end":81},"obj":"NNS"},{"id":"T686","span":{"begin":62,"end":71},"obj":"JJ"},{"id":"T685","span":{"begin":52,"end":61},"obj":"VB"},{"id":"T684","span":{"begin":48,"end":51},"obj":"CC"},{"id":"T683","span":{"begin":46,"end":47},"obj":","},{"id":"T682","span":{"begin":42,"end":46},"obj":"NNP"},{"id":"T681","span":{"begin":38,"end":41},"obj":"CC"},{"id":"T680","span":{"begin":34,"end":37},"obj":"NN"},{"id":"T679","span":{"begin":31,"end":33},"obj":"IN"},{"id":"T678","span":{"begin":21,"end":30},"obj":"NN"},{"id":"T677","span":{"begin":13,"end":20},"obj":"VBN"},{"id":"T676","span":{"begin":9,"end":12},"obj":"DT"},{"id":"T675","span":{"begin":5,"end":8},"obj":"IN"},{"id":"T714","span":{"begin":231,"end":236},"obj":"IN"}],"relations":[{"id":"R395","pred":"punct","subj":"T683","obj":"T682"},{"id":"R388","pred":"det","subj":"T676","obj":"T678"},{"id":"R389","pred":"amod","subj":"T677","obj":"T678"},{"id":"R390","pred":"pobj","subj":"T678","obj":"T675"},{"id":"R391","pred":"prep","subj":"T679","obj":"T678"},{"id":"R392","pred":"pobj","subj":"T680","obj":"T679"},{"id":"R393","pred":"cc","subj":"T681","obj":"T680"},{"id":"R394","pred":"conj","subj":"T682","obj":"T680"},{"id":"R398","pred":"amod","subj":"T686","obj":"T687"},{"id":"R399","pred":"dobj","subj":"T687","obj":"T685"},{"id":"R400","pred":"nsubj","subj":"T688","obj":"T698"},{"id":"R401","pred":"amod","subj":"T689","obj":"T690"},{"id":"R402","pred":"nsubj","subj":"T690","obj":"T698"},{"id":"R403","pred":"cc","subj":"T691","obj":"T690"},{"id":"R404","pred":"amod","subj":"T692","obj":"T693"},{"id":"R405","pred":"conj","subj":"T693","obj":"T690"},{"id":"R406","pred":"punct","subj":"T694","obj":"T693"},{"id":"R407","pred":"cc","subj":"T695","obj":"T693"},{"id":"R408","pred":"conj","subj":"T696","obj":"T693"},{"id":"R409","pred":"punct","subj":"T697","obj":"T698"},{"id":"R410","pred":"relcl","subj":"T698","obj":"T687"},{"id":"R411","pred":"det","subj":"T699","obj":"T701"},{"id":"R412","pred":"amod","subj":"T700","obj":"T701"},{"id":"R413","pred":"dobj","subj":"T701","obj":"T698"},{"id":"R414","pred":"prep","subj":"T702","obj":"T701"},{"id":"R415","pred":"pobj","subj":"T703","obj":"T702"},{"id":"R417","pred":"nsubj","subj":"T705","obj":"T706"},{"id":"R418","pred":"ROOT","subj":"T706","obj":"T706"},{"id":"R419","pred":"mark","subj":"T707","obj":"T719"},{"id":"R420","pred":"csubj","subj":"T708","obj":"T719"},{"id":"R421","pred":"compound","subj":"T709","obj":"T710"},{"id":"R422","pred":"dobj","subj":"T710","obj":"T708"},{"id":"R423","pred":"prep","subj":"T711","obj":"T710"},{"id":"R424","pred":"amod","subj":"T712","obj":"T713"},{"id":"R425","pred":"pobj","subj":"T713","obj":"T711"},{"id":"R426","pred":"amod","subj":"T715","obj":"T717"},{"id":"R427","pred":"amod","subj":"T716","obj":"T717"},{"id":"R428","pred":"pobj","subj":"T717","obj":"T714"},{"id":"R429","pred":"auxpass","subj":"T718","obj":"T719"},{"id":"R430","pred":"ccomp","subj":"T719","obj":"T706"},{"id":"R431","pred":"aux","subj":"T720","obj":"T721"},{"id":"R432","pred":"advcl","subj":"T721","obj":"T719"},{"id":"R433","pred":"compound","subj":"T722","obj":"T723"},{"id":"R434","pred":"dobj","subj":"T723","obj":"T721"},{"id":"R435","pred":"cc","subj":"T724","obj":"T721"},{"id":"R436","pred":"conj","subj":"T725","obj":"T721"},{"id":"R437","pred":"compound","subj":"T726","obj":"T728"},{"id":"R438","pred":"compound","subj":"T727","obj":"T728"},{"id":"R439","pred":"dobj","subj":"T728","obj":"T725"},{"id":"R440","pred":"punct","subj":"T729","obj":"T706"},{"id":"R443","pred":"prep","subj":"T714","obj":"T710"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T548","span":{"begin":194,"end":209},"obj":"Positive_regulation"},{"id":"T545","span":{"begin":194,"end":198},"obj":"Protein"},{"id":"T544","span":{"begin":285,"end":288},"obj":"Entity"},{"id":"T542","span":{"begin":213,"end":230},"obj":"Entity"},{"id":"T538","span":{"begin":34,"end":37},"obj":"Protein"},{"id":"T536","span":{"begin":237,"end":240},"obj":"Protein"},{"id":"T530","span":{"begin":158,"end":165},"obj":"Protein"},{"id":"T528","span":{"begin":101,"end":125},"obj":"Protein"},{"id":"T522","span":{"begin":42,"end":46},"obj":"Protein"}],"relations":[{"id":"R264","pred":"themeOf","subj":"T545","obj":"T548"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"DLUT931","denotations":[{"id":"T424","span":{"begin":183,"end":193},"obj":"Positive_regulation"},{"id":"T423","span":{"begin":252,"end":262},"obj":"Negative_regulation"},{"id":"T422","span":{"begin":199,"end":209},"obj":"Positive_regulation"},{"id":"T421","span":{"begin":126,"end":134},"obj":"Regulation"},{"id":"T414","span":{"begin":237,"end":240},"obj":"Protein"},{"id":"T413","span":{"begin":194,"end":198},"obj":"Protein"},{"id":"T412","span":{"begin":161,"end":165},"obj":"Protein"},{"id":"T411","span":{"begin":108,"end":111},"obj":"Protein"},{"id":"T410","span":{"begin":42,"end":46},"obj":"Protein"},{"id":"T409","span":{"begin":34,"end":37},"obj":"Protein"}],"relations":[{"id":"R218","pred":"causeOf","subj":"T411","obj":"T421"},{"id":"R219","pred":"themeOf","subj":"T412","obj":"T421"},{"id":"R220","pred":"themeOf","subj":"T413","obj":"T422"},{"id":"R221","pred":"themeOf","subj":"T414","obj":"T423"},{"id":"R224","pred":"themeOf","subj":"T422","obj":"T424"},{"id":"R225","pred":"causeOf","subj":"T423","obj":"T424"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T473","span":{"begin":199,"end":209},"obj":"Positive_regulation"},{"id":"T472","span":{"begin":183,"end":193},"obj":"Positive_regulation"},{"id":"T471","span":{"begin":252,"end":262},"obj":"Negative_regulation"},{"id":"T464","span":{"begin":237,"end":240},"obj":"Protein"},{"id":"T463","span":{"begin":194,"end":198},"obj":"Protein"},{"id":"T462","span":{"begin":161,"end":165},"obj":"Protein"},{"id":"T461","span":{"begin":108,"end":111},"obj":"Protein"},{"id":"T460","span":{"begin":42,"end":46},"obj":"Protein"},{"id":"T459","span":{"begin":34,"end":37},"obj":"Protein"}],"relations":[{"id":"R234","pred":"themeOf","subj":"T463","obj":"T473"},{"id":"R235","pred":"themeOf","subj":"T464","obj":"T471"},{"id":"R238","pred":"themeOf","subj":"T473","obj":"T472"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"BioNLP16_DUT","denotations":[{"id":"T380","span":{"begin":183,"end":193},"obj":"Positive_regulation"},{"id":"T379","span":{"begin":199,"end":209},"obj":"Positive_regulation"},{"id":"T378","span":{"begin":252,"end":262},"obj":"Negative_regulation"},{"id":"T372","span":{"begin":237,"end":240},"obj":"Protein"},{"id":"T371","span":{"begin":194,"end":198},"obj":"Protein"},{"id":"T370","span":{"begin":161,"end":165},"obj":"Protein"},{"id":"T369","span":{"begin":108,"end":111},"obj":"Protein"},{"id":"T368","span":{"begin":42,"end":46},"obj":"Protein"},{"id":"T367","span":{"begin":34,"end":37},"obj":"Protein"}],"relations":[{"id":"R208","pred":"themeOf","subj":"T371","obj":"T379"},{"id":"R209","pred":"themeOf","subj":"T372","obj":"T378"},{"id":"R211","pred":"themeOf","subj":"T379","obj":"T380"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T395","span":{"begin":108,"end":111},"obj":"http://www.uniprot.org/uniprot/P04637"},{"id":"T394","span":{"begin":34,"end":37},"obj":"http://www.uniprot.org/uniprot/P04637"},{"id":"T387","span":{"begin":161,"end":165},"obj":"http://www.uniprot.org/uniprot/Q9NZC7"},{"id":"T386","span":{"begin":42,"end":46},"obj":"http://www.uniprot.org/uniprot/Q9NZC7"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T130","span":{"begin":34,"end":37},"obj":"Protein"},{"id":"T131","span":{"begin":42,"end":46},"obj":"Protein"},{"id":"T132","span":{"begin":108,"end":111},"obj":"Protein"},{"id":"T133","span":{"begin":161,"end":165},"obj":"Protein"},{"id":"T134","span":{"begin":194,"end":198},"obj":"Protein"},{"id":"T135","span":{"begin":237,"end":240},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"pmc-enju-pas","denotations":[{"id":"T336","span":{"begin":320,"end":325},"obj":"NN"},{"id":"T335","span":{"begin":315,"end":319},"obj":"NN"},{"id":"T334","span":{"begin":311,"end":314},"obj":"NN"},{"id":"T333","span":{"begin":304,"end":310},"obj":"VB"},{"id":"T332","span":{"begin":300,"end":303},"obj":"CC"},{"id":"T331","span":{"begin":289,"end":299},"obj":"NN"},{"id":"T330","span":{"begin":285,"end":288},"obj":"NN"},{"id":"T329","span":{"begin":276,"end":284},"obj":"VB"},{"id":"T328","span":{"begin":273,"end":275},"obj":"TO"},{"id":"T327","span":{"begin":266,"end":272},"obj":"VB"},{"id":"T326","span":{"begin":263,"end":265},"obj":"VB"},{"id":"T325","span":{"begin":252,"end":262},"obj":"NN"},{"id":"T324","span":{"begin":241,"end":251},"obj":"JJ"},{"id":"T323","span":{"begin":237,"end":240},"obj":"NN"},{"id":"T322","span":{"begin":231,"end":236},"obj":"IN"},{"id":"T321","span":{"begin":225,"end":230},"obj":"NN"},{"id":"T320","span":{"begin":213,"end":224},"obj":"JJ"},{"id":"T319","span":{"begin":210,"end":212},"obj":"IN"},{"id":"T318","span":{"begin":199,"end":209},"obj":"NN"},{"id":"T317","span":{"begin":194,"end":198},"obj":"NN"},{"id":"T316","span":{"begin":183,"end":193},"obj":"VB"},{"id":"T315","span":{"begin":178,"end":182},"obj":"IN"},{"id":"T314","span":{"begin":170,"end":177},"obj":"VB"},{"id":"T313","span":{"begin":167,"end":169},"obj":"PRP"},{"id":"T312","span":{"begin":161,"end":165},"obj":"NN"},{"id":"T311","span":{"begin":158,"end":160},"obj":"IN"},{"id":"T310","span":{"begin":149,"end":157},"obj":"NN"},{"id":"T309","span":{"begin":139,"end":148},"obj":"JJ"},{"id":"T308","span":{"begin":135,"end":138},"obj":"DT"},{"id":"T307","span":{"begin":126,"end":134},"obj":"VB"},{"id":"T306","span":{"begin":124,"end":125},"obj":"-COMMA-"},{"id":"T305","span":{"begin":116,"end":124},"obj":"NN"},{"id":"T304","span":{"begin":113,"end":115},"obj":"CC"},{"id":"T303","span":{"begin":111,"end":112},"obj":"-COMMA-"},{"id":"T302","span":{"begin":108,"end":111},"obj":"NN"},{"id":"T301","span":{"begin":101,"end":107},"obj":"JJ"},{"id":"T300","span":{"begin":97,"end":100},"obj":"CC"},{"id":"T299","span":{"begin":92,"end":96},"obj":"NN"},{"id":"T298","span":{"begin":87,"end":91},"obj":"JJ"},{"id":"T297","span":{"begin":82,"end":86},"obj":"IN"},{"id":"T296","span":{"begin":72,"end":81},"obj":"NN"},{"id":"T295","span":{"begin":62,"end":71},"obj":"JJ"},{"id":"T294","span":{"begin":52,"end":61},"obj":"VB"},{"id":"T293","span":{"begin":48,"end":51},"obj":"CC"},{"id":"T292","span":{"begin":46,"end":47},"obj":"-COMMA-"},{"id":"T291","span":{"begin":42,"end":46},"obj":"NN"},{"id":"T290","span":{"begin":38,"end":41},"obj":"CC"},{"id":"T289","span":{"begin":34,"end":37},"obj":"NN"},{"id":"T288","span":{"begin":31,"end":33},"obj":"IN"},{"id":"T287","span":{"begin":21,"end":30},"obj":"NN"},{"id":"T286","span":{"begin":13,"end":20},"obj":"VB"},{"id":"T285","span":{"begin":9,"end":12},"obj":"DT"},{"id":"T284","span":{"begin":5,"end":8},"obj":"IN"}],"relations":[{"id":"R152","pred":"arg2Of","subj":"T287","obj":"T286"},{"id":"R150","pred":"arg2Of","subj":"T287","obj":"T284"},{"id":"R151","pred":"arg1Of","subj":"T287","obj":"T285"},{"id":"R153","pred":"arg1Of","subj":"T287","obj":"T288"},{"id":"R154","pred":"arg1Of","subj":"T289","obj":"T290"},{"id":"R155","pred":"arg2Of","subj":"T290","obj":"T288"},{"id":"R156","pred":"arg2Of","subj":"T291","obj":"T290"},{"id":"R159","pred":"arg1Of","subj":"T293","obj":"T292"},{"id":"R160","pred":"arg2Of","subj":"T294","obj":"T293"},{"id":"R161","pred":"arg2Of","subj":"T296","obj":"T294"},{"id":"R162","pred":"arg1Of","subj":"T296","obj":"T295"},{"id":"R163","pred":"arg1Of","subj":"T296","obj":"T297"},{"id":"R164","pred":"arg1Of","subj":"T299","obj":"T298"},{"id":"R165","pred":"arg1Of","subj":"T299","obj":"T300"},{"id":"R166","pred":"arg1Of","subj":"T300","obj":"T304"},{"id":"R167","pred":"arg2Of","subj":"T302","obj":"T300"},{"id":"R168","pred":"arg1Of","subj":"T302","obj":"T301"},{"id":"R169","pred":"arg1Of","subj":"T304","obj":"T303"},{"id":"R170","pred":"arg1Of","subj":"T304","obj":"T307"},{"id":"R171","pred":"arg2Of","subj":"T305","obj":"T304"},{"id":"R172","pred":"arg2Of","subj":"T307","obj":"T297"},{"id":"R173","pred":"arg1Of","subj":"T307","obj":"T306"},{"id":"R174","pred":"arg2Of","subj":"T310","obj":"T307"},{"id":"R175","pred":"arg1Of","subj":"T310","obj":"T308"},{"id":"R176","pred":"arg1Of","subj":"T310","obj":"T309"},{"id":"R177","pred":"arg1Of","subj":"T310","obj":"T311"},{"id":"R178","pred":"arg2Of","subj":"T312","obj":"T311"},{"id":"R179","pred":"arg1Of","subj":"T313","obj":"T314"},{"id":"R180","pred":"arg1Of","subj":"T318","obj":"T316"},{"id":"R181","pred":"arg1Of","subj":"T318","obj":"T317"},{"id":"R182","pred":"arg1Of","subj":"T318","obj":"T319"},{"id":"R183","pred":"arg1Of","subj":"T318","obj":"T322"},{"id":"R184","pred":"arg1Of","subj":"T318","obj":"T326"},{"id":"R185","pred":"arg2Of","subj":"T318","obj":"T327"},{"id":"R186","pred":"arg2Of","subj":"T321","obj":"T319"},{"id":"R187","pred":"arg1Of","subj":"T321","obj":"T320"},{"id":"R188","pred":"arg2Of","subj":"T325","obj":"T322"},{"id":"R189","pred":"arg1Of","subj":"T325","obj":"T323"},{"id":"R190","pred":"arg1Of","subj":"T325","obj":"T324"},{"id":"R191","pred":"arg2Of","subj":"T327","obj":"T314"},{"id":"R192","pred":"arg1Of","subj":"T327","obj":"T315"},{"id":"R193","pred":"arg2Of","subj":"T327","obj":"T326"},{"id":"R194","pred":"modOf","subj":"T327","obj":"T328"},{"id":"R195","pred":"arg1Of","subj":"T329","obj":"T332"},{"id":"R196","pred":"arg2Of","subj":"T331","obj":"T329"},{"id":"R197","pred":"arg1Of","subj":"T331","obj":"T330"},{"id":"R198","pred":"arg1Of","subj":"T332","obj":"T328"},{"id":"R199","pred":"arg2Of","subj":"T333","obj":"T332"},{"id":"R200","pred":"arg2Of","subj":"T336","obj":"T333"},{"id":"R201","pred":"arg1Of","subj":"T336","obj":"T334"},{"id":"R202","pred":"arg1Of","subj":"T336","obj":"T335"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"GO-BP","denotations":[{"id":"T144","span":{"begin":320,"end":325},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T143","span":{"begin":315,"end":325},"obj":"http://purl.obolibrary.org/obo/GO_0008219"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"GO-CC","denotations":[{"id":"T147","span":{"begin":315,"end":319},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"sentences","denotations":[{"id":"T86","span":{"begin":167,"end":326},"obj":"Sentence"},{"id":"T9","span":{"begin":167,"end":326},"obj":"Sentence"},{"id":"T10","span":{"begin":328,"end":385},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}

{"project":"simple1","denotations":[{"id":"T165","span":{"begin":237,"end":240},"obj":"Protein"},{"id":"T164","span":{"begin":194,"end":198},"obj":"Protein"},{"id":"T163","span":{"begin":161,"end":165},"obj":"Protein"},{"id":"T162","span":{"begin":108,"end":111},"obj":"Protein"},{"id":"T161","span":{"begin":42,"end":46},"obj":"Protein"},{"id":"T160","span":{"begin":34,"end":37},"obj":"Protein"}],"text":"view for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMechanisms of Resistance to Temozolomide in Glioblastomas\nGlio"}