PMC:3586680 / 693-1083 JSONTXT

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    test3

    {"project":"test3","denotations":[{"id":"T78","span":{"begin":295,"end":298},"obj":"Protein"},{"id":"T77","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T76","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T75","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T74","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T73","span":{"begin":92,"end":95},"obj":"Protein"},{"id":"T72","span":{"begin":29,"end":32},"obj":"Protein"},{"id":"T71","span":{"begin":0,"end":4},"obj":"Binding"},{"id":"T58","span":{"begin":295,"end":298},"obj":"Protein"},{"id":"T57","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T56","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T55","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T54","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T53","span":{"begin":92,"end":95},"obj":"Protein"},{"id":"T52","span":{"begin":29,"end":32},"obj":"Protein"}],"relations":[{"id":"R8","pred":"themeOf","subj":"T72","obj":"T71"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    testone

    {"project":"testone","denotations":[{"id":"T40","span":{"begin":0,"end":4},"obj":"Binding"},{"id":"T36","span":{"begin":295,"end":298},"obj":"Protein"},{"id":"T35","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T34","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T33","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T32","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T31","span":{"begin":92,"end":95},"obj":"Protein"},{"id":"T30","span":{"begin":29,"end":32},"obj":"Protein"}],"relations":[{"id":"R3","pred":"themeOf","subj":"T30","obj":"T40"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    bionlp-st-ge-2016-test-tees

    {"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T496","span":{"begin":310,"end":320},"obj":"Negative_regulation"},{"id":"T495","span":{"begin":295,"end":298},"obj":"Protein"},{"id":"T494","span":{"begin":184,"end":192},"obj":"Regulation"},{"id":"T493","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T492","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T491","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T490","span":{"begin":92,"end":95},"obj":"Protein"},{"id":"T489","span":{"begin":0,"end":4},"obj":"Binding"},{"id":"T488","span":{"begin":0,"end":4},"obj":"Binding"},{"id":"T487","span":{"begin":29,"end":32},"obj":"Protein"}],"relations":[{"id":"R245","pred":"themeOf","subj":"T487","obj":"T489"},{"id":"R246","pred":"causeOf","subj":"T492","obj":"T494"},{"id":"R247","pred":"themeOf","subj":"T493","obj":"T494"},{"id":"R248","pred":"themeOf","subj":"T495","obj":"T496"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    bionlp-st-ge-2016-spacy-parsed

    {"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T729","span":{"begin":383,"end":384},"obj":"."},{"id":"T728","span":{"begin":378,"end":383},"obj":"NN"},{"id":"T727","span":{"begin":373,"end":377},"obj":"NN"},{"id":"T726","span":{"begin":369,"end":372},"obj":"NNP"},{"id":"T725","span":{"begin":362,"end":368},"obj":"VB"},{"id":"T724","span":{"begin":358,"end":361},"obj":"CC"},{"id":"T723","span":{"begin":347,"end":357},"obj":"NN"},{"id":"T722","span":{"begin":343,"end":346},"obj":"NNP"},{"id":"T721","span":{"begin":334,"end":342},"obj":"VB"},{"id":"T720","span":{"begin":331,"end":333},"obj":"TO"},{"id":"T719","span":{"begin":324,"end":330},"obj":"VBN"},{"id":"T718","span":{"begin":321,"end":323},"obj":"VBZ"},{"id":"T717","span":{"begin":310,"end":320},"obj":"NN"},{"id":"T716","span":{"begin":299,"end":309},"obj":"JJ"},{"id":"T715","span":{"begin":295,"end":298},"obj":"NN"},{"id":"T713","span":{"begin":283,"end":288},"obj":"NNS"},{"id":"T712","span":{"begin":271,"end":282},"obj":"JJ"},{"id":"T711","span":{"begin":268,"end":270},"obj":"IN"},{"id":"T710","span":{"begin":257,"end":267},"obj":"NN"},{"id":"T709","span":{"begin":252,"end":256},"obj":"NNP"},{"id":"T708","span":{"begin":241,"end":251},"obj":"VBG"},{"id":"T707","span":{"begin":236,"end":240},"obj":"IN"},{"id":"T706","span":{"begin":228,"end":235},"obj":"VBP"},{"id":"T705","span":{"begin":225,"end":227},"obj":"PRP"},{"id":"T704","span":{"begin":223,"end":224},"obj":"."},{"id":"T703","span":{"begin":219,"end":223},"obj":"NNP"},{"id":"T702","span":{"begin":216,"end":218},"obj":"IN"},{"id":"T701","span":{"begin":207,"end":215},"obj":"NN"},{"id":"T700","span":{"begin":197,"end":206},"obj":"JJ"},{"id":"T699","span":{"begin":193,"end":196},"obj":"DT"},{"id":"T698","span":{"begin":184,"end":192},"obj":"VBP"},{"id":"T697","span":{"begin":182,"end":183},"obj":","},{"id":"T696","span":{"begin":174,"end":182},"obj":"NNS"},{"id":"T695","span":{"begin":171,"end":173},"obj":"CC"},{"id":"T694","span":{"begin":169,"end":170},"obj":","},{"id":"T693","span":{"begin":166,"end":169},"obj":"NN"},{"id":"T692","span":{"begin":159,"end":165},"obj":"JJ"},{"id":"T691","span":{"begin":155,"end":158},"obj":"CC"},{"id":"T690","span":{"begin":150,"end":154},"obj":"NN"},{"id":"T689","span":{"begin":145,"end":149},"obj":"JJ"},{"id":"T688","span":{"begin":140,"end":144},"obj":"WDT"},{"id":"T687","span":{"begin":130,"end":139},"obj":"NNS"},{"id":"T686","span":{"begin":120,"end":129},"obj":"JJ"},{"id":"T685","span":{"begin":110,"end":119},"obj":"VB"},{"id":"T684","span":{"begin":106,"end":109},"obj":"CC"},{"id":"T683","span":{"begin":104,"end":105},"obj":","},{"id":"T682","span":{"begin":100,"end":104},"obj":"NNP"},{"id":"T681","span":{"begin":96,"end":99},"obj":"CC"},{"id":"T680","span":{"begin":92,"end":95},"obj":"NN"},{"id":"T679","span":{"begin":89,"end":91},"obj":"IN"},{"id":"T678","span":{"begin":79,"end":88},"obj":"NN"},{"id":"T677","span":{"begin":71,"end":78},"obj":"VBN"},{"id":"T676","span":{"begin":67,"end":70},"obj":"DT"},{"id":"T675","span":{"begin":63,"end":66},"obj":"IN"},{"id":"T674","span":{"begin":54,"end":62},"obj":"NN"},{"id":"T673","span":{"begin":51,"end":53},"obj":"DT"},{"id":"T672","span":{"begin":43,"end":50},"obj":"VBP"},{"id":"T671","span":{"begin":40,"end":42},"obj":"PRP"},{"id":"T670","span":{"begin":38,"end":39},"obj":","},{"id":"T669","span":{"begin":34,"end":38},"obj":"RB"},{"id":"T668","span":{"begin":32,"end":33},"obj":"."},{"id":"T667","span":{"begin":29,"end":32},"obj":"NN"},{"id":"T666","span":{"begin":24,"end":28},"obj":"NN"},{"id":"T665","span":{"begin":19,"end":23},"obj":"JJ"},{"id":"T664","span":{"begin":9,"end":18},"obj":"VB"},{"id":"T663","span":{"begin":5,"end":8},"obj":"CC"},{"id":"T662","span":{"begin":0,"end":4},"obj":"NN"},{"id":"T714","span":{"begin":289,"end":294},"obj":"IN"}],"relations":[{"id":"R395","pred":"punct","subj":"T683","obj":"T682"},{"id":"R377","pred":"amod","subj":"T665","obj":"T666"},{"id":"R378","pred":"compound","subj":"T666","obj":"T667"},{"id":"R379","pred":"dobj","subj":"T667","obj":"T664"},{"id":"R381","pred":"advmod","subj":"T669","obj":"T672"},{"id":"R382","pred":"punct","subj":"T670","obj":"T672"},{"id":"R383","pred":"nsubj","subj":"T671","obj":"T672"},{"id":"R384","pred":"ROOT","subj":"T672","obj":"T672"},{"id":"R385","pred":"det","subj":"T673","obj":"T674"},{"id":"R386","pred":"dobj","subj":"T674","obj":"T672"},{"id":"R387","pred":"prep","subj":"T675","obj":"T674"},{"id":"R388","pred":"det","subj":"T676","obj":"T678"},{"id":"R389","pred":"amod","subj":"T677","obj":"T678"},{"id":"R390","pred":"pobj","subj":"T678","obj":"T675"},{"id":"R391","pred":"prep","subj":"T679","obj":"T678"},{"id":"R392","pred":"pobj","subj":"T680","obj":"T679"},{"id":"R393","pred":"cc","subj":"T681","obj":"T680"},{"id":"R394","pred":"conj","subj":"T682","obj":"T680"},{"id":"R396","pred":"cc","subj":"T684","obj":"T672"},{"id":"R397","pred":"conj","subj":"T685","obj":"T672"},{"id":"R398","pred":"amod","subj":"T686","obj":"T6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and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    bionlp-st-ge-2016-test-ihmc

    {"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T548","span":{"begin":252,"end":267},"obj":"Positive_regulation"},{"id":"T545","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T544","span":{"begin":343,"end":346},"obj":"Entity"},{"id":"T542","span":{"begin":271,"end":288},"obj":"Entity"},{"id":"T538","span":{"begin":92,"end":95},"obj":"Protein"},{"id":"T536","span":{"begin":295,"end":298},"obj":"Protein"},{"id":"T530","span":{"begin":216,"end":223},"obj":"Protein"},{"id":"T528","span":{"begin":159,"end":183},"obj":"Protein"},{"id":"T522","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T520","span":{"begin":19,"end":32},"obj":"Protein"}],"relations":[{"id":"R264","pred":"themeOf","subj":"T545","obj":"T548"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    DLUT931

    {"project":"DLUT931","denotations":[{"id":"T424","span":{"begin":241,"end":251},"obj":"Positive_regulation"},{"id":"T423","span":{"begin":310,"end":320},"obj":"Negative_regulation"},{"id":"T422","span":{"begin":257,"end":267},"obj":"Positive_regulation"},{"id":"T421","span":{"begin":184,"end":192},"obj":"Regulation"},{"id":"T420","span":{"begin":0,"end":4},"obj":"Binding"},{"id":"T414","span":{"begin":295,"end":298},"obj":"Protein"},{"id":"T413","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T412","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T411","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T410","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T409","span":{"begin":92,"end":95},"obj":"Protein"},{"id":"T408","span":{"begin":29,"end":32},"obj":"Protein"}],"relations":[{"id":"R217","pred":"themeOf","subj":"T408","obj":"T420"},{"id":"R218","pred":"causeOf","subj":"T411","obj":"T421"},{"id":"R219","pred":"themeOf","subj":"T412","obj":"T421"},{"id":"R220","pred":"themeOf","subj":"T413","obj":"T422"},{"id":"R221","pred":"themeOf","subj":"T414","obj":"T423"},{"id":"R224","pred":"themeOf","subj":"T422","obj":"T424"},{"id":"R225","pred":"causeOf","subj":"T423","obj":"T424"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    BioNLP16_Messiy

    {"project":"BioNLP16_Messiy","denotations":[{"id":"T473","span":{"begin":257,"end":267},"obj":"Positive_regulation"},{"id":"T472","span":{"begin":241,"end":251},"obj":"Positive_regulation"},{"id":"T471","span":{"begin":310,"end":320},"obj":"Negative_regulation"},{"id":"T470","span":{"begin":0,"end":4},"obj":"Binding"},{"id":"T464","span":{"begin":295,"end":298},"obj":"Protein"},{"id":"T463","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T462","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T461","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T460","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T459","span":{"begin":92,"end":95},"obj":"Protein"},{"id":"T458","span":{"begin":29,"end":32},"obj":"Protein"}],"relations":[{"id":"R234","pred":"themeOf","subj":"T463","obj":"T473"},{"id":"R235","pred":"themeOf","subj":"T464","obj":"T471"},{"id":"R238","pred":"themeOf","subj":"T473","obj":"T472"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    BioNLP16_DUT

    {"project":"BioNLP16_DUT","denotations":[{"id":"T380","span":{"begin":241,"end":251},"obj":"Positive_regulation"},{"id":"T379","span":{"begin":257,"end":267},"obj":"Positive_regulation"},{"id":"T378","span":{"begin":310,"end":320},"obj":"Negative_regulation"},{"id":"T377","span":{"begin":0,"end":4},"obj":"Binding"},{"id":"T376","span":{"begin":9,"end":18},"obj":"Positive_regulation"},{"id":"T372","span":{"begin":295,"end":298},"obj":"Protein"},{"id":"T371","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T370","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T369","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T368","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T367","span":{"begin":92,"end":95},"obj":"Protein"},{"id":"T366","span":{"begin":29,"end":32},"obj":"Protein"}],"relations":[{"id":"R207","pred":"themeOf","subj":"T366","obj":"T376"},{"id":"R208","pred":"themeOf","subj":"T371","obj":"T379"},{"id":"R209","pred":"themeOf","subj":"T372","obj":"T378"},{"id":"R211","pred":"themeOf","subj":"T379","obj":"T380"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    bionlp-st-ge-2016-uniprot

    {"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T395","span":{"begin":166,"end":169},"obj":"http://www.uniprot.org/uniprot/P04637"},{"id":"T394","span":{"begin":92,"end":95},"obj":"http://www.uniprot.org/uniprot/P04637"},{"id":"T393","span":{"begin":29,"end":32},"obj":"http://www.uniprot.org/uniprot/P04637"},{"id":"T387","span":{"begin":219,"end":223},"obj":"http://www.uniprot.org/uniprot/Q9NZC7"},{"id":"T386","span":{"begin":100,"end":104},"obj":"http://www.uniprot.org/uniprot/Q9NZC7"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    bionlp-st-ge-2016-test-proteins

    {"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T129","span":{"begin":29,"end":32},"obj":"Protein"},{"id":"T130","span":{"begin":92,"end":95},"obj":"Protein"},{"id":"T131","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T132","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T133","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T134","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T135","span":{"begin":295,"end":298},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    pmc-enju-pas

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and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    GO-BP

    {"project":"GO-BP","denotations":[{"id":"T144","span":{"begin":378,"end":383},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T143","span":{"begin":373,"end":383},"obj":"http://purl.obolibrary.org/obo/GO_0008219"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    GO-CC

    {"project":"GO-CC","denotations":[{"id":"T147","span":{"begin":373,"end":377},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    sentences

    {"project":"sentences","denotations":[{"id":"T86","span":{"begin":225,"end":384},"obj":"Sentence"},{"id":"T85","span":{"begin":34,"end":224},"obj":"Sentence"},{"id":"T8","span":{"begin":34,"end":224},"obj":"Sentence"},{"id":"T9","span":{"begin":225,"end":384},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}

    simple1

    {"project":"simple1","denotations":[{"id":"T165","span":{"begin":295,"end":298},"obj":"Protein"},{"id":"T164","span":{"begin":252,"end":256},"obj":"Protein"},{"id":"T163","span":{"begin":219,"end":223},"obj":"Protein"},{"id":"T162","span":{"begin":166,"end":169},"obj":"Protein"},{"id":"T161","span":{"begin":100,"end":104},"obj":"Protein"},{"id":"T160","span":{"begin":92,"end":95},"obj":"Protein"},{"id":"T159","span":{"begin":29,"end":32},"obj":"Protein"}],"text":"bind and stabilize wild type p53. Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX. We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.\n\nMech"}