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induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b). The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003). Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010). However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013). Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012). MAPO2 gene encodes a novel 37-kDa protein. It is not determined whether this gene is involved in autophagy."}

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induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b). The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003). Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010). However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013). Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012). MAPO2 gene encodes a novel 37-kDa protein. It is not determined whether this gene is involved in autophagy."}

{"project":"2_test","denotations":[{"id":"23459853-21406402-38778491","span":{"begin":133,"end":137},"obj":"21406402"},{"id":"23459853-14705733-38778493","span":{"begin":280,"end":284},"obj":"14705733"},{"id":"23459853-20587533-38778494","span":{"begin":447,"end":451},"obj":"20587533"},{"id":"23459853-23383259-38778495","span":{"begin":603,"end":607},"obj":"23383259"},{"id":"23459853-23028632-38778496","span":{"begin":718,"end":722},"obj":"23028632"}],"text":"Temozolomide induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b). The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003). Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010). However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013). Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012). MAPO2 gene encodes a novel 37-kDa protein. It is not determined whether this gene is involved in autophagy."}

{"project":"GO-BP","denotations":[{"id":"T1989","span":{"begin":521,"end":533},"obj":"http://purl.obolibrary.org/obo/GO_0043066"},{"id":"T1988","span":{"begin":374,"end":390},"obj":"http://purl.obolibrary.org/obo/GO_0048102"},{"id":"T1986","span":{"begin":385,"end":390},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T1985","span":{"begin":257,"end":262},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T1983","span":{"begin":252,"end":262},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T1981","span":{"begin":690,"end":699},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T1980","span":{"begin":562,"end":571},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T1979","span":{"begin":232,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T1977","span":{"begin":690,"end":699},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T1976","span":{"begin":562,"end":571},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T1975","span":{"begin":232,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T1974","span":{"begin":822,"end":831},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T1973","span":{"begin":508,"end":517},"obj":"http://purl.obolibrary.org/obo/GO_0006914"},{"id":"T1972","span":{"begin":209,"end":218},"obj":"http://purl.obolibrary.org/obo/GO_0006914"}],"text":"Temozolomide induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b). The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003). Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010). However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013). Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012). MAPO2 gene encodes a novel 37-kDa protein. It is not determined whether this gene is involved in autophagy."}

{"project":"GO-CC","denotations":[{"id":"T2036","span":{"begin":579,"end":584},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Temozolomide induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b). The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003). Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010). However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013). Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012). MAPO2 gene encodes a novel 37-kDa protein. It is not determined whether this gene is involved in autophagy."}

{"project":"sentences","denotations":[{"id":"T886","span":{"begin":768,"end":832},"obj":"Sentence"},{"id":"T885","span":{"begin":725,"end":767},"obj":"Sentence"},{"id":"T884","span":{"begin":610,"end":724},"obj":"Sentence"},{"id":"T883","span":{"begin":454,"end":609},"obj":"Sentence"},{"id":"T882","span":{"begin":287,"end":453},"obj":"Sentence"},{"id":"T881","span":{"begin":161,"end":286},"obj":"Sentence"},{"id":"T880","span":{"begin":0,"end":160},"obj":"Sentence"},{"id":"T16","span":{"begin":0,"end":160},"obj":"Sentence"},{"id":"T17","span":{"begin":161,"end":286},"obj":"Sentence"},{"id":"T18","span":{"begin":287,"end":453},"obj":"Sentence"},{"id":"T19","span":{"begin":454,"end":609},"obj":"Sentence"},{"id":"T20","span":{"begin":610,"end":724},"obj":"Sentence"},{"id":"T21","span":{"begin":725,"end":767},"obj":"Sentence"},{"id":"T22","span":{"begin":768,"end":832},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Temozolomide induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b). The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003). Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010). However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013). Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012). MAPO2 gene encodes a novel 37-kDa protein. It is not determined whether this gene is involved in autophagy."}

{"project":"simple1","denotations":[{"id":"T2052","span":{"begin":725,"end":730},"obj":"Protein"},{"id":"T2051","span":{"begin":623,"end":631},"obj":"Protein"},{"id":"T2050","span":{"begin":616,"end":621},"obj":"Protein"},{"id":"T2049","span":{"begin":336,"end":341},"obj":"Protein"},{"id":"T2048","span":{"begin":321,"end":326},"obj":"Protein"}],"text":"Temozolomide induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b). The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003). Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010). However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013). Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012). MAPO2 gene encodes a novel 37-kDa protein. It is not determined whether this gene is involved in autophagy."}