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WWOX affects TMZ sensitivity has never been determined. Binding proteins for WWOX and/or p53 are likely to affect apoptosis and TMZ sensitivity in GBM cells. WWOX binds MEK, and that PMA dissociates this complex for causing apoptosis of T leukemia cells (Lin et al., 2011). Thus, appropriate chemicals, which break apart the WWOX/MEK complex, are expected to cause GBM cell death. Preliminary studies from our screening of chemicals have selected certain small molecules that induce apoptosis of many types of cancer cells (Lu et al., unpublished). Indeed, specific inhibition of MEK by selumetinib enhances TMZ-induced cancer cell death in vivo (Holt et al., 2012). Serum factors can be utilized for blocking cancer growth. For example, serum complement C1q induces apoptosis of prostate cancer and neuroblastomas cells without participation of downstream proteins in the classical activation pathway (Hong et al., 2009). In this event, ectopic WWOX is activated for inducing apoptosis."}

{"project":"2_test","denotations":[{"id":"23459853-21901168-38778593","span":{"begin":275,"end":279},"obj":"21901168"},{"id":"23459853-22343622-38778594","span":{"begin":668,"end":672},"obj":"22343622"},{"id":"23459853-19484134-38778595","span":{"begin":924,"end":928},"obj":"19484134"}],"text":"Whether WWOX affects TMZ sensitivity has never been determined. Binding proteins for WWOX and/or p53 are likely to affect apoptosis and TMZ sensitivity in GBM cells. WWOX binds MEK, and that PMA dissociates this complex for causing apoptosis of T leukemia cells (Lin et al., 2011). Thus, appropriate chemicals, which break apart the WWOX/MEK complex, are expected to cause GBM cell death. Preliminary studies from our screening of chemicals have selected certain small molecules that induce apoptosis of many types of cancer cells (Lu et al., unpublished). Indeed, specific inhibition of MEK by selumetinib enhances TMZ-induced cancer cell death in vivo (Holt et al., 2012). Serum factors can be utilized for blocking cancer growth. For example, serum complement C1q induces apoptosis of prostate cancer and neuroblastomas cells without participation of downstream proteins in the classical activation pathway (Hong et al., 2009). In this event, ectopic WWOX is activated for inducing apoptosis."}

{"project":"UBERON-AE","denotations":[{"id":"T9734","span":{"begin":746,"end":751},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"Whether WWOX affects TMZ sensitivity has never been determined. Binding proteins for WWOX and/or p53 are likely to affect apoptosis and TMZ sensitivity in GBM cells. WWOX binds MEK, and that PMA dissociates this complex for causing apoptosis of T leukemia cells (Lin et al., 2011). Thus, appropriate chemicals, which break apart the WWOX/MEK complex, are expected to cause GBM cell death. Preliminary studies from our screening of chemicals have selected certain small molecules that induce apoptosis of many types of cancer cells (Lu et al., unpublished). Indeed, specific inhibition of MEK by selumetinib enhances TMZ-induced cancer cell death in vivo (Holt et al., 2012). Serum factors can be utilized for blocking cancer growth. For example, serum complement C1q induces apoptosis of prostate cancer and neuroblastomas cells without participation of downstream proteins in the classical activation pathway (Hong et al., 2009). In this event, ectopic WWOX is activated for inducing apoptosis."}

{"project":"GO-BP","denotations":[{"id":"T9922","span":{"begin":725,"end":731},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T9920","span":{"begin":640,"end":645},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T9919","span":{"begin":382,"end":387},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T9918","span":{"begin":635,"end":645},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T9917","span":{"begin":377,"end":387},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T9913","span":{"begin":985,"end":994},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T9912","span":{"begin":775,"end":784},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T9911","span":{"begin":491,"end":500},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T9910","span":{"begin":232,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T9909","span":{"begin":122,"end":131},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T9905","span":{"begin":985,"end":994},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T9904","span":{"begin":775,"end":784},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T9903","span":{"begin":491,"end":500},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T9902","span":{"begin":232,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T9901","span":{"begin":122,"end":131},"obj":"http://purl.obolibrary.org/obo/GO_0006915"}],"text":"Whether WWOX affects TMZ sensitivity has never been determined. Binding proteins for WWOX and/or p53 are likely to affect apoptosis and TMZ sensitivity in GBM cells. WWOX binds MEK, and that PMA dissociates this complex for causing apoptosis of T leukemia cells (Lin et al., 2011). Thus, appropriate chemicals, which break apart the WWOX/MEK complex, are expected to cause GBM cell death. Preliminary studies from our screening of chemicals have selected certain small molecules that induce apoptosis of many types of cancer cells (Lu et al., unpublished). Indeed, specific inhibition of MEK by selumetinib enhances TMZ-induced cancer cell death in vivo (Holt et al., 2012). Serum factors can be utilized for blocking cancer growth. For example, serum complement C1q induces apoptosis of prostate cancer and neuroblastomas cells without participation of downstream proteins in the classical activation pathway (Hong et al., 2009). In this event, ectopic WWOX is activated for inducing apoptosis."}

{"project":"GO-MF","denotations":[{"id":"T9953","span":{"begin":64,"end":80},"obj":"http://purl.obolibrary.org/obo/GO_0005515"},{"id":"T9951","span":{"begin":64,"end":71},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"Whether WWOX affects TMZ sensitivity has never been determined. Binding proteins for WWOX and/or p53 are likely to affect apoptosis and TMZ sensitivity in GBM cells. WWOX binds MEK, and that PMA dissociates this complex for causing apoptosis of T leukemia cells (Lin et al., 2011). Thus, appropriate chemicals, which break apart the WWOX/MEK complex, are expected to cause GBM cell death. Preliminary studies from our screening of chemicals have selected certain small molecules that induce apoptosis of many types of cancer cells (Lu et al., unpublished). Indeed, specific inhibition of MEK by selumetinib enhances TMZ-induced cancer cell death in vivo (Holt et al., 2012). Serum factors can be utilized for blocking cancer growth. For example, serum complement C1q induces apoptosis of prostate cancer and neuroblastomas cells without participation of downstream proteins in the classical activation pathway (Hong et al., 2009). In this event, ectopic WWOX is activated for inducing apoptosis."}

{"project":"GO-CC","denotations":[{"id":"T9961","span":{"begin":823,"end":828},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T9960","span":{"begin":525,"end":530},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T9959","span":{"begin":256,"end":261},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T9958","span":{"begin":159,"end":164},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Whether WWOX affects TMZ sensitivity has never been determined. Binding proteins for WWOX and/or p53 are likely to affect apoptosis and TMZ sensitivity in GBM cells. WWOX binds MEK, and that PMA dissociates this complex for causing apoptosis of T leukemia cells (Lin et al., 2011). Thus, appropriate chemicals, which break apart the WWOX/MEK complex, are expected to cause GBM cell death. Preliminary studies from our screening of chemicals have selected certain small molecules that induce apoptosis of many types of cancer cells (Lu et al., unpublished). Indeed, specific inhibition of MEK by selumetinib enhances TMZ-induced cancer cell death in vivo (Holt et al., 2012). Serum factors can be utilized for blocking cancer growth. For example, serum complement C1q induces apoptosis of prostate cancer and neuroblastomas cells without participation of downstream proteins in the classical activation pathway (Hong et al., 2009). In this event, ectopic WWOX is activated for inducing apoptosis."}

{"project":"sentences","denotations":[{"id":"T9751","span":{"begin":931,"end":995},"obj":"Sentence"},{"id":"T9750","span":{"begin":733,"end":930},"obj":"Sentence"},{"id":"T9749","span":{"begin":675,"end":732},"obj":"Sentence"},{"id":"T9748","span":{"begin":557,"end":674},"obj":"Sentence"},{"id":"T9747","span":{"begin":389,"end":556},"obj":"Sentence"},{"id":"T9746","span":{"begin":282,"end":388},"obj":"Sentence"},{"id":"T9745","span":{"begin":166,"end":281},"obj":"Sentence"},{"id":"T9744","span":{"begin":64,"end":165},"obj":"Sentence"},{"id":"T9743","span":{"begin":0,"end":63},"obj":"Sentence"},{"id":"T124","span":{"begin":0,"end":63},"obj":"Sentence"},{"id":"T125","span":{"begin":64,"end":165},"obj":"Sentence"},{"id":"T126","span":{"begin":166,"end":281},"obj":"Sentence"},{"id":"T127","span":{"begin":282,"end":388},"obj":"Sentence"},{"id":"T128","span":{"begin":389,"end":556},"obj":"Sentence"},{"id":"T129","span":{"begin":557,"end":674},"obj":"Sentence"},{"id":"T130","span":{"begin":675,"end":732},"obj":"Sentence"},{"id":"T131","span":{"begin":733,"end":930},"obj":"Sentence"},{"id":"T132","span":{"begin":931,"end":995},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Whether WWOX affects TMZ sensitivity has never been determined. Binding proteins for WWOX and/or p53 are likely to affect apoptosis and TMZ sensitivity in GBM cells. WWOX binds MEK, and that PMA dissociates this complex for causing apoptosis of T leukemia cells (Lin et al., 2011). Thus, appropriate chemicals, which break apart the WWOX/MEK complex, are expected to cause GBM cell death. Preliminary studies from our screening of chemicals have selected certain small molecules that induce apoptosis of many types of cancer cells (Lu et al., unpublished). Indeed, specific inhibition of MEK by selumetinib enhances TMZ-induced cancer cell death in vivo (Holt et al., 2012). Serum factors can be utilized for blocking cancer growth. For example, serum complement C1q induces apoptosis of prostate cancer and neuroblastomas cells without participation of downstream proteins in the classical activation pathway (Hong et al., 2009). In this event, ectopic WWOX is activated for inducing apoptosis."}

{"project":"simple1","denotations":[{"id":"T10029","span":{"begin":954,"end":958},"obj":"Protein"},{"id":"T10028","span":{"begin":166,"end":170},"obj":"Protein"},{"id":"T10027","span":{"begin":97,"end":100},"obj":"Protein"},{"id":"T10026","span":{"begin":85,"end":89},"obj":"Protein"},{"id":"T10025","span":{"begin":8,"end":12},"obj":"Protein"}],"text":"Whether WWOX affects TMZ sensitivity has never been determined. Binding proteins for WWOX and/or p53 are likely to affect apoptosis and TMZ sensitivity in GBM cells. WWOX binds MEK, and that PMA dissociates this complex for causing apoptosis of T leukemia cells (Lin et al., 2011). Thus, appropriate chemicals, which break apart the WWOX/MEK complex, are expected to cause GBM cell death. Preliminary studies from our screening of chemicals have selected certain small molecules that induce apoptosis of many types of cancer cells (Lu et al., unpublished). Indeed, specific inhibition of MEK by selumetinib enhances TMZ-induced cancer cell death in vivo (Holt et al., 2012). Serum factors can be utilized for blocking cancer growth. For example, serum complement C1q induces apoptosis of prostate cancer and neuroblastomas cells without participation of downstream proteins in the classical activation pathway (Hong et al., 2009). In this event, ectopic WWOX is activated for inducing apoptosis."}