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{"project":"BioNLP16_Messiy","denotations":[{"id":"T5410","span":{"begin":866,"end":871},"obj":"Binding"},{"id":"T5409","span":{"begin":745,"end":752},"obj":"Binding"},{"id":"T5408","span":{"begin":698,"end":706},"obj":"Positive_regulation"},{"id":"T5407","span":{"begin":542,"end":557},"obj":"Phosphorylation"},{"id":"T5406","span":{"begin":529,"end":536},"obj":"Positive_regulation"},{"id":"T5405","span":{"begin":521,"end":528},"obj":"Positive_regulation"},{"id":"T5404","span":{"begin":344,"end":354},"obj":"Gene_expression"},{"id":"T5403","span":{"begin":377,"end":384},"obj":"Positive_regulation"},{"id":"T5402","span":{"begin":430,"end":437},"obj":"Positive_regulation"},{"id":"T5401","span":{"begin":415,"end":425},"obj":"Positive_regulation"},{"id":"T5400","span":{"begin":122,"end":129},"obj":"Positive_regulation"},{"id":"T5399","span":{"begin":138,"end":149},"obj":"Localization"},{"id":"T5398","span":{"begin":5,"end":10},"obj":"Binding"},{"id":"T5373","span":{"begin":872,"end":878},"obj":"Protein"},{"id":"T5372","span":{"begin":836,"end":865},"obj":"Protein"},{"id":"T5371","span":{"begin":810,"end":815},"obj":"Protein"},{"id":"T5370","span":{"begin":772,"end":778},"obj":"Protein"},{"id":"T5369","span":{"begin":690,"end":694},"obj":"Protein"},{"id":"T5368","span":{"begin":537,"end":541},"obj":"Protein"},{"id":"T5367","span":{"begin":402,"end":414},"obj":"Protein"},{"id":"T5366","span":{"begin":385,"end":397},"obj":"Protein"},{"id":"T5365","span":{"begin":358,"end":362},"obj":"Protein"},{"id":"T5364","span":{"begin":130,"end":134},"obj":"Protein"},{"id":"T5363","span":{"begin":0,"end":4},"obj":"Protein"}],"relations":[{"id":"R3702","pred":"themeOf","subj":"T5401","obj":"T5403"},{"id":"R3733","pred":"themeOf","subj":"T5401","obj":"T5403"},{"id":"R3735","pred":"themeOf","subj":"T5404","obj":"T5402"},{"id":"R3739","pred":"themeOf","subj":"T5404","obj":"T5403"},{"id":"R3742","pred":"themeOf","subj":"T5407","obj":"T5405"},{"id":"R3748","pred":"themeOf","subj":"T5407","obj":"T5406"},{"id":"R3749","pred":"themeOf","subj":"T5409","obj":"T5408"},{"id":"R3751","pred":"themeOf","subj":"T5363","obj":"T5398"},{"id":"R3752","pred":"themeOf","subj":"T5364","obj":"T5400"},{"id":"R3753","pred":"themeOf","subj":"T5364","obj":"T5399"},{"id":"R3754","pred":"themeOf","subj":"T5365","obj":"T5404"},{"id":"R3755","pred":"themeOf","subj":"T5409","obj":"T5408"},{"id":"R3756","pred":"themeOf","subj":"T5366","obj":"T5401"},{"id":"R3758","pred":"themeOf","subj":"T5367","obj":"T5401"},{"id":"R3759","pred":"themeOf","subj":"T5368","obj":"T5407"},{"id":"R3760","pred":"themeOf","subj":"T5370","obj":"T5409"},{"id":"R3761","pred":"themeOf","subj":"T5371","obj":"T5409"},{"id":"R3762","pred":"themeOf","subj":"T5372","obj":"T5410"},{"id":"R3763","pred":"themeOf","subj":"T5373","obj":"T5410"}],"text":"WWOX binds MEK in Jurkat T cells (Lin et al., 2011). Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft. Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012). Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a). Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009). A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009)."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T5133","span":{"begin":866,"end":871},"obj":"Binding"},{"id":"T5132","span":{"begin":745,"end":752},"obj":"Binding"},{"id":"T5131","span":{"begin":521,"end":528},"obj":"Positive_regulation"},{"id":"T5130","span":{"begin":542,"end":557},"obj":"Phosphorylation"},{"id":"T5129","span":{"begin":430,"end":437},"obj":"Positive_regulation"},{"id":"T5128","span":{"begin":377,"end":384},"obj":"Positive_regulation"},{"id":"T5127","span":{"begin":344,"end":354},"obj":"Gene_expression"},{"id":"T5126","span":{"begin":415,"end":425},"obj":"Positive_regulation"},{"id":"T5125","span":{"begin":122,"end":129},"obj":"Positive_regulation"},{"id":"T5124","span":{"begin":5,"end":10},"obj":"Binding"},{"id":"T5100","span":{"begin":872,"end":878},"obj":"Protein"},{"id":"T5099","span":{"begin":836,"end":865},"obj":"Protein"},{"id":"T5098","span":{"begin":810,"end":815},"obj":"Protein"},{"id":"T5097","span":{"begin":772,"end":778},"obj":"Protein"},{"id":"T5096","span":{"begin":690,"end":694},"obj":"Protein"},{"id":"T5095","span":{"begin":537,"end":541},"obj":"Protein"},{"id":"T5094","span":{"begin":402,"end":414},"obj":"Protein"},{"id":"T5093","span":{"begin":385,"end":397},"obj":"Protein"},{"id":"T5092","span":{"begin":358,"end":362},"obj":"Protein"},{"id":"T5091","span":{"begin":130,"end":134},"obj":"Protein"},{"id":"T5090","span":{"begin":0,"end":4},"obj":"Protein"}],"relations":[{"id":"R3619","pred":"themeOf","subj":"T5090","obj":"T5124"},{"id":"R3620","pred":"themeOf","subj":"T5091","obj":"T5125"},{"id":"R3621","pred":"themeOf","subj":"T5092","obj":"T5127"},{"id":"R3622","pred":"themeOf","subj":"T5093","obj":"T5126"},{"id":"R3623","pred":"themeOf","subj":"T5094","obj":"T5126"},{"id":"R3624","pred":"themeOf","subj":"T5095","obj":"T5130"},{"id":"R3625","pred":"themeOf","subj":"T5097","obj":"T5132"},{"id":"R3626","pred":"themeOf","subj":"T5099","obj":"T5133"},{"id":"R3627","pred":"themeOf","subj":"T5100","obj":"T5133"},{"id":"R3634","pred":"themeOf","subj":"T5126","obj":"T5128"},{"id":"R3635","pred":"themeOf","subj":"T5126","obj":"T5128"},{"id":"R3636","pred":"themeOf","subj":"T5127","obj":"T5129"},{"id":"R3637","pred":"themeOf","subj":"T5130","obj":"T5131"}],"text":"WWOX binds MEK in Jurkat T cells (Lin et al., 2011). Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft. Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012). Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a). Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009). A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009)."}

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binds MEK in Jurkat T cells (Lin et al., 2011). Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft. Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012). Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a). Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009). A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009)."}

{"project":"2_test","denotations":[{"id":"23459853-21901168-38778565","span":{"begin":46,"end":50},"obj":"21901168"},{"id":"23459853-22343622-38778566","span":{"begin":329,"end":333},"obj":"22343622"},{"id":"23459853-19484134-38778567","span":{"begin":670,"end":674},"obj":"19484134"},{"id":"23459853-19366691-38778568","span":{"begin":792,"end":796},"obj":"19366691"},{"id":"23459853-16438931-38778569","span":{"begin":829,"end":833},"obj":"16438931"},{"id":"23459853-19366691-38778570","span":{"begin":1046,"end":1050},"obj":"19366691"}],"text":"WWOX binds MEK in Jurkat T cells (Lin et al., 2011). Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft. Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012). Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a). Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009). A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009)."}

{"project":"UBERON-AE","denotations":[{"id":"T3822","span":{"begin":937,"end":941},"obj":"http://purl.obolibrary.org/obo/UBERON_3000101"},{"id":"T3821","span":{"begin":872,"end":876},"obj":"http://purl.obolibrary.org/obo/UBERON_3000101"},{"id":"T3820","span":{"begin":772,"end":776},"obj":"http://purl.obolibrary.org/obo/UBERON_3000101"}],"text":"WWOX binds MEK in Jurkat T cells (Lin et al., 2011). Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft. Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012). Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a). Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009). A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009)."}

{"project":"GO-BP","denotations":[{"id":"T4039","span":{"begin":849,"end":855},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T4038","span":{"begin":308,"end":314},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T4036","span":{"begin":585,"end":594},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T4035","span":{"begin":180,"end":189},"obj":"http://purl.obolibrary.org/obo/GO_0097194"},{"id":"T4030","span":{"begin":585,"end":594},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T4029","span":{"begin":180,"end":189},"obj":"http://purl.obolibrary.org/obo/GO_0006915"},{"id":"T4065","span":{"begin":915,"end":924},"obj":"http://purl.obolibrary.org/obo/GO_0009058"},{"id":"T4064","span":{"begin":626,"end":655},"obj":"http://purl.obolibrary.org/obo/GO_0006957"},{"id":"T4063","span":{"begin":626,"end":655},"obj":"http://purl.obolibrary.org/obo/GO_0006958"},{"id":"T4062","span":{"begin":626,"end":647},"obj":"http://purl.obolibrary.org/obo/GO_0006956"},{"id":"T4061","span":{"begin":451,"end":482},"obj":"http://purl.obolibrary.org/obo/GO_0032976"},{"id":"T4060","span":{"begin":303,"end":314},"obj":"http://purl.obolibrary.org/obo/GO_0016049"},{"id":"T4059","span":{"begin":246,"end":258},"obj":"http://purl.obolibrary.org/obo/GO_0004708"},{"id":"T4050","span":{"begin":904,"end":910},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T4048","span":{"begin":542,"end":557},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"WWOX binds MEK in Jurkat T cells (Lin et al., 2011). Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft. Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012). Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a). Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009). A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009)."}

{"project":"GO-MF","denotations":[{"id":"T4076","span":{"begin":745,"end":752},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T4075","span":{"begin":698,"end":706},"obj":"http://purl.obolibrary.org/obo/GO_0043495"},{"id":"T4071","span":{"begin":438,"end":448},"obj":"http://purl.obolibrary.org/obo/GO_0045155"},{"id":"T4070","span":{"begin":438,"end":448},"obj":"http://purl.obolibrary.org/obo/GO_0045154"},{"id":"T4069","span":{"begin":438,"end":448},"obj":"http://purl.obolibrary.org/obo/GO_0045153"},{"id":"T4068","span":{"begin":246,"end":258},"obj":"http://purl.obolibrary.org/obo/GO_0004708"},{"id":"T4074","span":{"begin":438,"end":448},"obj":"http://purl.obolibrary.org/obo/GO_0045158"},{"id":"T4073","span":{"begin":438,"end":448},"obj":"http://purl.obolibrary.org/obo/GO_0045157"},{"id":"T4072","span":{"begin":438,"end":448},"obj":"http://purl.obolibrary.org/obo/GO_0045156"}],"text":"WWOX binds MEK in Jurkat T cells (Lin et al., 2011). Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft. Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012). Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a). Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009). A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009)."}

{"project":"GO-CC","denotations":[{"id":"T4091","span":{"begin":977,"end":984},"obj":"http://purl.obolibrary.org/obo/GO_0005634"},{"id":"T4090","span":{"begin":723,"end":735},"obj":"http://purl.obolibrary.org/obo/GO_0005856"},{"id":"T4089","span":{"begin":714,"end":722},"obj":"http://purl.obolibrary.org/obo/GO_0016020"},{"id":"T4088","span":{"begin":698,"end":722},"obj":"http://purl.obolibrary.org/obo/GO_0031225"},{"id":"T4087","span":{"begin":220,"end":230},"obj":"http://purl.obolibrary.org/obo/GO_0045121"},{"id":"T4086","span":{"begin":470,"end":482},"obj":"http://purl.obolibrary.org/obo/GO_0005739"},{"id":"T4085","span":{"begin":157,"end":169},"obj":"http://purl.obolibrary.org/obo/GO_0005739"},{"id":"T4081","span":{"begin":580,"end":584},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4080","span":{"begin":371,"end":376},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T4079","span":{"begin":27,"end":32},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"WWOX binds MEK in Jurkat T cells (Lin et al., 2011). Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft. Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012). Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a). Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009). A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009)."}

{"project":"sentences","denotations":[{"id":"T3848","span":{"begin":836,"end":1052},"obj":"Sentence"},{"id":"T3847","span":{"begin":677,"end":835},"obj":"Sentence"},{"id":"T3846","span":{"begin":506,"end":676},"obj":"Sentence"},{"id":"T3845","span":{"begin":336,"end":505},"obj":"Sentence"},{"id":"T3844","span":{"begin":232,"end":335},"obj":"Sentence"},{"id":"T3843","span":{"begin":53,"end":231},"obj":"Sentence"},{"id":"T3842","span":{"begin":0,"end":52},"obj":"Sentence"},{"id":"T83","span":{"begin":0,"end":52},"obj":"Sentence"},{"id":"T84","span":{"begin":53,"end":231},"obj":"Sentence"},{"id":"T85","span":{"begin":232,"end":335},"obj":"Sentence"},{"id":"T86","span":{"begin":336,"end":505},"obj":"Sentence"},{"id":"T87","span":{"begin":506,"end":676},"obj":"Sentence"},{"id":"T88","span":{"begin":677,"end":835},"obj":"Sentence"},{"id":"T89","span":{"begin":836,"end":1052},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"WWOX binds MEK in Jurkat T cells (Lin et al., 2011). Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft. Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012). Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a). Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009). A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009)."}

{"project":"simple1","denotations":[{"id":"T4146","span":{"begin":872,"end":878},"obj":"Protein"},{"id":"T4145","span":{"begin":836,"end":865},"obj":"Protein"},{"id":"T4144","span":{"begin":810,"end":815},"obj":"Protein"},{"id":"T4143","span":{"begin":772,"end":778},"obj":"Protein"},{"id":"T4142","span":{"begin":690,"end":694},"obj":"Protein"},{"id":"T4141","span":{"begin":537,"end":541},"obj":"Protein"},{"id":"T4140","span":{"begin":402,"end":414},"obj":"Protein"},{"id":"T4139","span":{"begin":385,"end":397},"obj":"Protein"},{"id":"T4138","span":{"begin":358,"end":362},"obj":"Protein"},{"id":"T4137","span":{"begin":130,"end":134},"obj":"Protein"},{"id":"T4136","span":{"begin":0,"end":4},"obj":"Protein"}],"text":"WWOX binds MEK in Jurkat T cells (Lin et al., 2011). Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft. Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012). Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a). Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009). A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006). Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009)."}