PMC:3586680 / 1137-2220
Annnotations
bionlp-st-ge-2016-test-tees
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bionlp-st-ge-2016-spacy-parsed
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"R1802","pred":"compound","subj":"T2711","obj":"T2712"},{"id":"R1804","pred":"ccomp","subj":"T2712","obj":"T2718"},{"id":"R1805","pred":"punct","subj":"T2713","obj":"T2712"},{"id":"R1806","pred":"npadvmod","subj":"T2714","obj":"T2712"},{"id":"R1807","pred":"punct","subj":"T2715","obj":"T2718"},{"id":"R1808","pred":"compound","subj":"T2716","obj":"T2718"},{"id":"R1809","pred":"nmod","subj":"T2717","obj":"T2718"},{"id":"R1811","pred":"ROOT","subj":"T2718","obj":"T2718"},{"id":"R1812","pred":"punct","subj":"T2719","obj":"T2720"},{"id":"R1814","pred":"amod","subj":"T2720","obj":"T2718"},{"id":"R1816","pred":"punct","subj":"T2721","obj":"T2720"},{"id":"R1817","pred":"punct","subj":"T2722","obj":"T2718"}],"text":"Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012). Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009). High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012). The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010). Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b)."}
bionlp-st-ge-2016-test-ihmc
{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T2488","span":{"begin":288,"end":302},"obj":"Entity"},{"id":"T2466","span":{"begin":118,"end":124},"obj":"Entity"},{"id":"T2465","span":{"begin":596,"end":650},"obj":"Entity"},{"id":"T2463","span":{"begin":444,"end":454},"obj":"Entity"},{"id":"T2456","span":{"begin":733,"end":736},"obj":"Entity"},{"id":"T2438","span":{"begin":767,"end":796},"obj":"Entity"},{"id":"T2429","span":{"begin":829,"end":936},"obj":"Entity"},{"id":"T2412","span":{"begin":810,"end":813},"obj":"Entity"},{"id":"T2405","span":{"begin":914,"end":926},"obj":"Protein"},{"id":"T2400","span":{"begin":615,"end":631},"obj":"Entity"},{"id":"T2399","span":{"begin":914,"end":919},"obj":"Protein"},{"id":"T2391","span":{"begin":646,"end":649},"obj":"Entity"},{"id":"T2373","span":{"begin":797,"end":801},"obj":"Entity"}],"text":"Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012). Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009). High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012). The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010). Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b)."}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T2139","span":{"begin":914,"end":919},"obj":"http://www.uniprot.org/uniprot/P40763"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012). Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009). High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012). The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010). Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b)."}
pmc-enju-pas
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multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012). Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009). High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012). The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010). Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b)."}
2_test
{"project":"2_test","denotations":[{"id":"23459853-10914698-38778478","span":{"begin":92,"end":96},"obj":"10914698"},{"id":"23459853-19269895-38778479","span":{"begin":112,"end":116},"obj":"19269895"},{"id":"23459853-22244911-38778480","span":{"begin":133,"end":137},"obj":"22244911"},{"id":"23459853-10914698-38778481","span":{"begin":305,"end":309},"obj":"10914698"},{"id":"23459853-19269895-38778482","span":{"begin":325,"end":329},"obj":"19269895"},{"id":"23459853-22228201-38778483","span":{"begin":457,"end":461},"obj":"22228201"},{"id":"23459853-10914698-38778484","span":{"begin":669,"end":673},"obj":"10914698"},{"id":"23459853-20885105-38778485","span":{"begin":686,"end":690},"obj":"20885105"},{"id":"23459853-22228201-38778486","span":{"begin":958,"end":962},"obj":"22228201"},{"id":"23459853-22594898-38778487","span":{"begin":1012,"end":1016},"obj":"22594898"},{"id":"23459853-22675172-38778488","span":{"begin":1034,"end":1038},"obj":"22675172"},{"id":"23459853-22532597-38778489","span":{"begin":1056,"end":1060},"obj":"22532597"}],"text":"Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012). Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009). High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012). The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010). Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b)."}
UBERON-AE
{"project":"UBERON-AE","denotations":[{"id":"T873","span":{"begin":890,"end":901},"obj":"http://purl.obolibrary.org/obo/UBERON_0003104"}],"text":"Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012). Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009). High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012). The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010). Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b)."}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T1971","span":{"begin":879,"end":912},"obj":"http://purl.obolibrary.org/obo/GO_0001837"},{"id":"T1970","span":{"begin":879,"end":912},"obj":"http://purl.obolibrary.org/obo/GO_0060317"},{"id":"T1969","span":{"begin":879,"end":912},"obj":"http://purl.obolibrary.org/obo/GO_0060231"},{"id":"T1968","span":{"begin":879,"end":912},"obj":"http://purl.obolibrary.org/obo/GO_0010717"},{"id":"T1967","span":{"begin":856,"end":877},"obj":"http://purl.obolibrary.org/obo/GO_0016575"}],"text":"Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012). Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009). High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012). The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010). Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b)."}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T2044","span":{"begin":810,"end":827},"obj":"http://purl.obolibrary.org/obo/GO_1990391"},{"id":"T2035","span":{"begin":835,"end":840},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T2034","span":{"begin":779,"end":784},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012). Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009). High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012). The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010). Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b)."}
sentences
{"project":"sentences","denotations":[{"id":"T879","span":{"begin":693,"end":1083},"obj":"Sentence"},{"id":"T878","span":{"begin":486,"end":692},"obj":"Sentence"},{"id":"T877","span":{"begin":332,"end":485},"obj":"Sentence"},{"id":"T876","span":{"begin":140,"end":331},"obj":"Sentence"},{"id":"T875","span":{"begin":0,"end":139},"obj":"Sentence"},{"id":"T11","span":{"begin":0,"end":139},"obj":"Sentence"},{"id":"T12","span":{"begin":140,"end":331},"obj":"Sentence"},{"id":"T13","span":{"begin":332,"end":485},"obj":"Sentence"},{"id":"T14","span":{"begin":486,"end":692},"obj":"Sentence"},{"id":"T15","span":{"begin":693,"end":1083},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012). Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009). High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012). The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010). Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b)."}