PMC:3586680 / 1079-6633 JSON TXT

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test3

Id	Subject	Object	Predicate	Lexical cue
T872	5445-5450	Protein	denotes	CD133
T871	5297-5302	Protein	denotes	CD133
T870	4764-4773	Negative_regulation	denotes	knockdown
T869	4758-4763	Protein	denotes	STAT3
T868	4745-4754	Negative_regulation	denotes	inhibitor
T867	4739-4744	Protein	denotes	STAT3
T866	4560-4564	Protein	denotes	MGMT
T865	4520-4528	Positive_regulation	denotes	increase
T864	4454-4459	Protein	denotes	IFN-β
T863	4440-4452	Protein	denotes	Interferon-β
T862	3968-3972	Protein	denotes	MGMT
T861	3314-3317	Protein	denotes	p53
T860	3098-3109	Protein	denotes	MicroRNA-21
T859	3019-3028	Protein	denotes	caspase-3
T858	3003-3008	Protein	denotes	Bcl-2
T857	2999-3002	Protein	denotes	Bax
T856	2991-2998	Negative_regulation	denotes	reduces
T855	2979-2990	Protein	denotes	microRNA-21
T854	2905-2915	Gene_expression	denotes	expression
T853	2892-2896	Protein	denotes	MGMT
T852	2847-2851	Protein	denotes	MGMT
T851	2835-2843	Positive_regulation	denotes	increase
T850	2750-2754	Protein	denotes	MGMT
T849	2708-2718	Binding	denotes	associated
T848	2441-2445	Protein	denotes	MGMT
T847	2427-2437	Gene_expression	denotes	expression
T846	2251-2260	Negative_regulation	denotes	deficient
T845	2181-2185	Protein	denotes	MGMT
T844	2079-2083	Protein	denotes	MGMT
T843	2039-2077	Protein	denotes	O6-methylguanine-DNA methyltransferase
T842	1867-1872	Protein	denotes	MAPO2
T841	1765-1773	Protein	denotes	C1orf201
T840	1758-1763	Protein	denotes	MAPO2
T839	1484-1493	Negative_regulation	denotes	inhibitor
T838	1478-1483	Protein	denotes	Bcl-2
T837	1463-1468	Protein	denotes	Bcl-2
T836	1435-1445	Negative_regulation	denotes	inhibition
T835	5445-5450	Protein	denotes	CD133
T834	5297-5302	Protein	denotes	CD133
T833	4758-4763	Protein	denotes	STAT3
T832	4739-4744	Protein	denotes	STAT3
T831	4560-4564	Protein	denotes	MGMT
T830	4454-4459	Protein	denotes	IFN-β
T829	4440-4452	Protein	denotes	Interferon-β
T828	3968-3972	Protein	denotes	MGMT
T827	3314-3317	Protein	denotes	p53
T826	3098-3109	Protein	denotes	MicroRNA-21
T825	3019-3028	Protein	denotes	caspase-3
T824	3003-3008	Protein	denotes	Bcl-2
T823	2999-3002	Protein	denotes	Bax
T822	2979-2990	Protein	denotes	microRNA-21
T821	2892-2896	Protein	denotes	MGMT
T820	2847-2851	Protein	denotes	MGMT
T819	2750-2754	Protein	denotes	MGMT
T818	2441-2445	Protein	denotes	MGMT
T817	2181-2185	Protein	denotes	MGMT
T816	2079-2083	Protein	denotes	MGMT
T815	2039-2077	Protein	denotes	O6-methylguanine-DNA methyltransferase
T814	1867-1872	Protein	denotes	MAPO2
T813	1765-1773	Protein	denotes	C1orf201
T812	1758-1763	Protein	denotes	MAPO2
T811	1478-1483	Protein	denotes	Bcl-2
T810	1463-1468	Protein	denotes	Bcl-2
R455	T837	T836	themeOf	Bcl-2,inhibition
R456	T838	T839	themeOf	Bcl-2,inhibitor
R457	T841	T840	equivalentTo	C1orf201,MAPO2
R458	T844	T843	equivalentTo	MGMT,O6-methylguanine-DNA methyltransferase
R459	T848	T847	themeOf	MGMT,expression
R460	T853	T854	themeOf	MGMT,expression
R461	T864	T863	equivalentTo	IFN-β,Interferon-β
R462	T867	T868	themeOf	STAT3,inhibitor
R463	T869	T870	themeOf	STAT3,knockdown

testone

Id	Subject	Object	Predicate	Lexical cue
T793	4440-4452	Protein	denotes	Interferon-β
T792	3968-3972	Protein	denotes	MGMT
T791	3314-3317	Protein	denotes	p53
T790	3098-3109	Protein	denotes	MicroRNA-21
T789	3019-3028	Protein	denotes	caspase-3
T788	3003-3008	Protein	denotes	Bcl-2
T787	2999-3002	Protein	denotes	Bax
T786	2979-2990	Protein	denotes	microRNA-21
T785	2892-2896	Protein	denotes	MGMT
T784	2847-2851	Protein	denotes	MGMT
T783	2750-2754	Protein	denotes	MGMT
T782	2441-2445	Protein	denotes	MGMT
T781	2181-2185	Protein	denotes	MGMT
T780	2079-2083	Protein	denotes	MGMT
T779	2039-2077	Protein	denotes	O6-methylguanine-DNA methyltransferase
T778	1867-1872	Protein	denotes	MAPO2
T777	1765-1773	Protein	denotes	C1orf201
T776	1758-1763	Protein	denotes	MAPO2
T775	1478-1483	Protein	denotes	Bcl-2
T774	1463-1468	Protein	denotes	Bcl-2
T809	5334-5343	Gene_expression	denotes	expressed
T808	4774-4785	Negative_regulation	denotes	potentiates
T807	4764-4773	Negative_regulation	denotes	knockdown
T806	4745-4754	Negative_regulation	denotes	inhibitor
T805	4520-4528	Positive_regulation	denotes	increase
T804	2905-2915	Gene_expression	denotes	expression
T803	2427-2437	Gene_expression	denotes	expression
T802	2251-2260	Negative_regulation	denotes	deficient
T801	1484-1493	Negative_regulation	denotes	inhibitor
T800	1435-1445	Negative_regulation	denotes	inhibition
T799	5445-5450	Protein	denotes	CD133
T798	5297-5302	Protein	denotes	CD133
T797	4758-4763	Protein	denotes	STAT3
T796	4739-4744	Protein	denotes	STAT3
T795	4560-4564	Protein	denotes	MGMT
T794	4454-4459	Protein	denotes	IFN-β
R444	T774	T800	themeOf	Bcl-2,inhibition
R445	T775	T801	themeOf	Bcl-2,inhibitor
R446	T777	T776	equivalentTo	C1orf201,MAPO2
R447	T780	T779	equivalentTo	MGMT,O6-methylguanine-DNA methyltransferase
R448	T782	T803	themeOf	MGMT,expression
R449	T785	T804	themeOf	MGMT,expression
R450	T793	T805	causeOf	Interferon-β,increase
R451	T794	T793	equivalentTo	IFN-β,Interferon-β
R452	T796	T806	themeOf	STAT3,inhibitor
R453	T797	T807	themeOf	STAT3,knockdown
R454	T798	T809	themeOf	CD133,expressed

bionlp-st-ge-2016-test-tees

Id	Subject	Object	Predicate	Lexical cue
T2314	5445-5450	Protein	denotes	CD133
T2313	5303-5311	Gene_expression	denotes	positive
T2312	5297-5302	Protein	denotes	CD133
T2311	4745-4754	Negative_regulation	denotes	inhibitor
T2310	4764-4773	Negative_regulation	denotes	knockdown
T2309	4745-4754	Negative_regulation	denotes	inhibitor
T2308	4758-4763	Protein	denotes	STAT3
T2307	4739-4744	Protein	denotes	STAT3
T2306	4691-4696	Protein	denotes	NF-κB
T2305	4500-4513	Protein	denotes	valproic acid
T2304	4560-4564	Protein	denotes	MGMT
T2303	4515-4518	Protein	denotes	VAP
T2302	3968-3972	Protein	denotes	MGMT
T2301	3817-3826	Regulation	denotes	regulated
T2300	3830-3850	Protein	denotes	cytochrome c oxidase
T2299	3552-3556	Protein	denotes	APNG
T2298	3493-3550	Protein	denotes	base excision repair enzyme alkylpurine-DNA-N-glycosylase
T2297	3408-3421	Protein	denotes	α5β1 integrin
T2296	3314-3317	Protein	denotes	p53
T2295	3279-3292	Protein	denotes	α5β1 integrin
T2294	2991-2998	Negative_regulation	denotes	reduces
T2293	2991-2998	Negative_regulation	denotes	reduces
T2292	2991-2998	Negative_regulation	denotes	reduces
T2291	3019-3028	Protein	denotes	caspase-3
T2290	3003-3008	Protein	denotes	Bcl-2
T2289	2999-3002	Protein	denotes	Bax
T2288	2885-2891	Negative_regulation	denotes	blocks
T2287	2905-2915	Gene_expression	denotes	expression
T2286	2835-2843	Positive_regulation	denotes	increase
T2285	2892-2904	Protein	denotes	MGMT protein
T2284	2847-2851	Protein	denotes	MGMT
T2283	2750-2768	Protein	denotes	MGMT gene promoter
T2282	2449-2453	Negative_regulation	denotes	loss
T2281	2427-2437	Gene_expression	denotes	expression
T2280	2441-2445	Protein	denotes	MGMT
T2279	2221-2231	Positive_regulation	denotes	activation
T2278	2279-2306	Protein	denotes	Rad3-related protein kinase
T2277	2181-2185	Protein	denotes	MGMT
T2276	2079-2083	Protein	denotes	MGMT
T2275	2039-2077	Protein	denotes	O6-methylguanine-DNA methyltransferase
T2274	1435-1445	Negative_regulation	denotes	inhibition
T2273	1449-1468	Protein	denotes	antiapoptotic Bcl-2
T2272	972-984	Protein	denotes	STAT3 kinase
T2271	914-921	Protein	denotes	histone
R1526	T2273	T2274	themeOf	antiapoptotic Bcl-2,inhibition
R1529	T2278	T2279	themeOf	Rad3-related protein kinase,activation
R1530	T2280	T2281	themeOf	MGMT,expression
R1532	T2281	T2282	themeOf	expression,loss
R1533	T2284	T2286	themeOf	MGMT,increase
R1534	T2285	T2287	themeOf	MGMT protein,expression
R1537	T2287	T2288	themeOf	expression,blocks
R1538	T2289	T2292	themeOf	Bax,reduces
R1540	T2290	T2293	themeOf	Bcl-2,reduces
R1541	T2291	T2294	themeOf	caspase-3,reduces
R1544	T2300	T2301	themeOf	cytochrome c oxidase,regulated
R1546	T2307	T2309	themeOf	STAT3,inhibitor
R1547	T2308	T2310	themeOf	STAT3,knockdown
R1548	T2310	T2311	themeOf	knockdown,inhibitor
R1549	T2312	T2313	themeOf	CD133,positive

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T3530	5553-5554	.	denotes	.
T3529	5542-5553	VBN	denotes	established
T3528	5539-5541	VB	denotes	be
T3527	5536-5538	TO	denotes	to
T3526	5532-5535	RB	denotes	yet
T3525	5528-5531	VBZ	denotes	has
T3524	5519-5527	NN	denotes	function
T3523	5508-5518	JJ	denotes	biological
T3522	5504-5507	PRP$	denotes	its
T3521	5501-5503	TO	denotes	to
T3520	5492-5500	JJ	denotes	relative
T3519	5486-5491	NNS	denotes	cells
T3518	5481-5485	NN	denotes	stem
T3517	5474-5480	NN	denotes	cancer
T3516	5467-5473	NN	denotes	glioma
T3515	5463-5466	IN	denotes	for
T3514	5456-5462	NN	denotes	marker
T3513	5454-5455	DT	denotes	a
T3512	5451-5453	IN	denotes	as
T3511	5445-5450	NNP	denotes	CD133
T3510	5442-5444	IN	denotes	of
T3509	5437-5441	NN	denotes	role
T3508	5433-5436	DT	denotes	the
T3507	5431-5432	,	denotes	,
T3506	5424-5431	RB	denotes	However
T3505	5422-5423	.	denotes	.
T3504	5421-5422	-RRB-	denotes	)
T3503	5417-5421	CD	denotes	2012
T3502	5415-5416	,	denotes	,
T3501	5405-5415	NNP	denotes	Pilkington
T3500	5401-5404	CC	denotes	and
T3499	5393-5400	NNP	denotes	Donovan
T3498	5392-5393	-LRB-	denotes	(
T3497	5386-5391	NNS	denotes	cells
T3496	5381-5385	NN	denotes	stem
T3495	5374-5380	NN	denotes	cancer
T3494	5370-5373	CC	denotes	and
T3493	5364-5369	NNS	denotes	cells
T3492	5359-5363	NN	denotes	stem
T3491	5352-5358	JJ	denotes	normal
T3490	5347-5351	DT	denotes	both
T3489	5344-5346	IN	denotes	in
T3488	5334-5343	VBN	denotes	expressed
T3487	5330-5333	VBP	denotes	are
T3486	5324-5329	NNS	denotes	cells
T3485	5319-5323	NN	denotes	stem
T3484	5312-5318	NN	denotes	cancer
T3483	5297-5311	JJ	denotes	CD133-positive
T3482	5295-5296	.	denotes	.
T3481	5294-5295	-RRB-	denotes	)
T3480	5290-5294	CD	denotes	2012
T3479	5288-5289	,	denotes	,
T3478	5285-5288	FW	denotes	al.
T3477	5282-5284	FW	denotes	et
T3476	5277-5281	NNP	denotes	Chen
T3475	5275-5276	:	denotes	;
T3474	5271-5275	CD	denotes	2011
T3473	5269-5270	,	denotes	,
T3472	5266-5269	FW	denotes	al.
T3471	5263-5265	FW	denotes	et
T3470	5257-5262	NNP	denotes	Beier
T3469	5256-5257	-LRB-	denotes	(
T3468	5248-5255	VBN	denotes	thought
T3467	5237-5247	RB	denotes	previously
T3466	5232-5236	IN	denotes	than
T3465	5220-5231	JJ	denotes	complicated
T3464	5215-5219	RBR	denotes	more
T3463	5210-5214	VBN	denotes	been
T3462	5206-5209	VBZ	denotes	has
T3461	5200-5205	NNS	denotes	drugs
T3460	5183-5199	JJ	denotes	chemotherapeutic
T3459	5177-5182	JJ	denotes	other
T3458	5173-5176	CC	denotes	and
T3457	5169-5172	NNP	denotes	TMZ
T3456	5164-5168	IN	denotes	with
T3455	5154-5163	NN	denotes	treatment
T3454	5149-5153	IN	denotes	from
T3453	5140-5148	NN	denotes	survival
T3452	5135-5139	NN	denotes	cell
T3451	5130-5134	NN	denotes	stem
T3450	5123-5129	NN	denotes	cancer
T3449	5120-5122	IN	denotes	of
T3448	5112-5119	NN	denotes	concept
T3447	5108-5111	DT	denotes	The
T3446	5106-5107	.	denotes	.
T3445	5097-5106	NN	denotes	treatment
T3444	5093-5096	NNP	denotes	TMZ
T3443	5090-5092	IN	denotes	in
T3442	5082-5089	NN	denotes	failure
T3441	5079-5081	TO	denotes	to
T3440	5075-5078	NN	denotes	key
T3439	5071-5074	DT	denotes	the
T3438	5062-5070	RB	denotes	probably
T3437	5058-5061	VBP	denotes	are
T3436	5052-5057	NNS	denotes	cells
T3435	5047-5051	NN	denotes	stem
T3434	5040-5046	NNP	denotes	Cancer
T3433	5038-5039	.	denotes	.
T3432	5037-5038	-RRB-	denotes	)
T3431	5033-5037	CD	denotes	2012
T3430	5031-5032	,	denotes	,
T3429	5028-5031	FW	denotes	al.
T3428	5025-5027	FW	denotes	et
T3427	5021-5024	NNP	denotes	Sun
T3426	5020-5021	-LRB-	denotes	(
T3425	5015-5019	NNS	denotes	GBMs
T3424	5012-5014	IN	denotes	in
T3423	5001-5011	NN	denotes	resistance
T3422	4997-5000	NNP	denotes	TMZ
T3421	4989-4996	VB	denotes	reverse
T3420	4986-4988	TO	denotes	to
T3419	4977-4985	VBN	denotes	utilized
T3418	4974-4976	VB	denotes	be
T3417	4970-4973	MD	denotes	can
T3416	4960-4969	NN	denotes	hyperoxia
T3415	4952-4959	VBN	denotes	Induced
T3414	4950-4951	.	denotes	.
T3413	4940-4950	NN	denotes	resistance
T3412	4936-4939	NNP	denotes	TMZ
T3411	4933-4935	IN	denotes	of
T3410	4921-4932	NN	denotes	development
T3409	4917-4920	DT	denotes	the
T3408	4912-4916	IN	denotes	with
T3407	4901-4911	VBN	denotes	associated
T3406	4898-4900	VB	denotes	be
T3405	4894-4897	MD	denotes	may
T3404	4890-4893	CC	denotes	and
T3403	4885-4889	NNS	denotes	GBMs
T3402	4882-4884	IN	denotes	in
T3401	4875-4881	JJ	denotes	common
T3400	4872-4874	VBZ	denotes	is
T3399	4864-4871	NN	denotes	hypoxia
T3398	4851-4863	NNP	denotes	Intratumoral
T3397	4849-4850	.	denotes	.
T3396	4848-4849	-RRB-	denotes	)
T3395	4844-4848	CD	denotes	2012
T3394	4842-4843	,	denotes	,
T3393	4839-4842	FW	denotes	al.
T3392	4836-4838	FW	denotes	et
T3391	4828-4835	NNP	denotes	Kohsaka
T3390	4827-4828	-LRB-	denotes	(
T3389	4821-4826	NNS	denotes	lines
T3388	4816-4820	NN	denotes	cell
T3387	4812-4815	NNP	denotes	GBM
T3386	4802-4811	JJ	denotes	resistant
T3385	4799-4801	IN	denotes	in
T3384	4790-4798	NN	denotes	efficacy
T3383	4786-4789	NNP	denotes	TMZ
T3382	4774-4785	NNS	denotes	potentiates
T3381	4764-4773	JJ	denotes	knockdown
T3380	4758-4763	CD	denotes	STAT3
T3379	4755-4757	CC	denotes	or
T3378	4745-4754	NN	denotes	inhibitor
T3377	4739-4744	CD	denotes	STAT3
T3376	4737-4738	.	denotes	.
T3375	4736-4737	-RRB-	denotes	)
T3374	4732-4736	CD	denotes	2012
T3373	4730-4731	,	denotes	,
T3372	4727-4730	FW	denotes	al.
T3371	4724-4726	FW	denotes	et
T3370	4718-4723	NNP	denotes	Huang
T3369	4717-4718	-LRB-	denotes	(
T3368	4707-4716	NN	denotes	mechanism
T3367	4691-4706	JJ	denotes	NF-κB-dependent
T3366	4688-4690	DT	denotes	an
T3365	4684-4687	IN	denotes	via
T3364	4673-4683	NN	denotes	resistance
T3363	4669-4672	NNP	denotes	TMZ
T3362	4660-4668	VBZ	denotes	reverses
T3361	4658-4659	,	denotes	,
T3332	4500-4508	JJ	denotes	valproic
T3331	4496-4499	CC	denotes	and
T3330	4494-4495	,	denotes	,
T3329	4483-4494	NN	denotes	resveratrol
T3328	4481-4482	,	denotes	,
T3327	4480-4481	-RRB-	denotes	)
T3326	4477-4480	NNP	denotes	LEV
T3325	4476-4477	-LRB-	denotes	(
T3324	4462-4475	NN	denotes	levetiracetam
T3323	4460-4461	,	denotes	,
T3322	4459-4460	-RRB-	denotes	)
T3321	4454-4459	NNP	denotes	IFN-β
T3320	4453-4454	-LRB-	denotes	(
T3319	4440-4452	NNP	denotes	Interferon-β
T3318	4438-4439	.	denotes	.
T3317	4437-4438	-RRB-	denotes	)
T3316	4433-4437	CD	denotes	2011
T3315	4431-4432	,	denotes	,
T3314	4428-4431	FW	denotes	al.
T3313	4425-4427	FW	denotes	et
T3312	4416-4424	NNP	denotes	Goellner
T3311	4415-4416	-LRB-	denotes	(
T3310	4411-4414	NNP	denotes	GBM
T3309	4401-4410	JJ	denotes	recurrent
T3308	4397-4400	CC	denotes	and
T3307	4387-4396	JJ	denotes	resistant
T3306	4382-4386	IN	denotes	with
T3305	4373-4381	NNS	denotes	patients
T3304	4370-4372	IN	denotes	in
T3303	4359-4369	NN	denotes	resistance
T3302	4355-4358	NNP	denotes	TMZ
T3301	4347-4354	VB	denotes	reverse
T3300	4343-4346	MD	denotes	may
T3299	4330-4342	NN	denotes	biosynthesis
T3298	4328-4329	-RRB-	denotes	)
T3297	4327-4328	VBN	denotes	+
T3296	4326-4327	-LRB-	denotes	(
T3295	4323-4326	NNP	denotes	NAD
T3294	4319-4322	CC	denotes	and
T3293	4312-4318	NN	denotes	repair
T3292	4303-4311	NN	denotes	excision
T3291	4298-4302	NN	denotes	base
T3290	4295-4297	IN	denotes	of
T3289	4285-4294	VBG	denotes	targeting
T3288	4280-4284	JJ	denotes	Dual
T3287	4278-4279	.	denotes	.
T3286	4277-4278	-RRB-	denotes	)
T3285	4272-4277	JJ	denotes	2012b
T3284	4270-4271	,	denotes	,
T3283	4267-4270	FW	denotes	al.
T3282	4264-4266	FW	denotes	et
T3281	4258-4263	NNP	denotes	Zhang
T3280	4256-4257	:	denotes	;
T3279	4252-4256	CD	denotes	2011
T3278	4250-4251	,	denotes	,
T3277	4247-4250	FW	denotes	al.
T3276	4244-4246	FW	denotes	et
T3275	4235-4243	NNP	denotes	Goellner
T3274	4234-4235	-LRB-	denotes	(
T3273	4224-4233	VBN	denotes	tolerated
T3272	4221-4223	CC	denotes	or
T3271	4212-4220	VBN	denotes	repaired
T3270	4208-4211	VBP	denotes	are
T3269	4200-4207	NNS	denotes	adducts
T3268	4183-4199	JJ	denotes	O6-methylguanine
T3267	4178-4182	WRB	denotes	when
T3266	4165-4177	RB	denotes	particularly
T3265	4152-4164	NN	denotes	cytotoxicity
T3264	4148-4151	NNP	denotes	TMZ
T3263	4145-4147	TO	denotes	to
T3262	4131-4144	RB	denotes	significantly
T3261	4119-4130	VBZ	denotes	contributes
T3260	4112-4118	NN	denotes	repair
T3259	4103-4111	NN	denotes	excision
T3258	4098-4102	NN	denotes	base
T3257	4095-4097	IN	denotes	of
T3256	4074-4094	NN	denotes	Methoxyamine-blocker
T3255	4072-4073	.	denotes	.
T3254	4071-4072	-RRB-	denotes	)
T3253	4066-4071	JJ	denotes	2012b
T3252	4064-4065	,	denotes	,
T3251	4061-4064	FW	denotes	al.
T3250	4058-4060	FW	denotes	et
T3249	4052-4057	NNP	denotes	Zhang
T3248	4051-4052	-LRB-	denotes	(
T3247	4047-4050	NNP	denotes	TMZ
T3246	4044-4046	TO	denotes	to
T3245	4037-4043	NNS	denotes	tumors
T3244	4027-4036	VB	denotes	sensitize
T3243	4024-4026	TO	denotes	to
T3242	4012-4023	NN	denotes	lomeguatrib
T3241	4008-4011	CC	denotes	and
T3240	3991-4007	NN	denotes	O6-benzylguanine
T3239	3989-3990	,	denotes	,
T3238	3973-3989	NNS	denotes	pseudosubstrates
T3237	3968-3972	NNP	denotes	MGMT
T3236	3965-3967	IN	denotes	by
T3235	3956-3964	VBN	denotes	achieved
T3234	3953-3955	VB	denotes	be
T3233	3949-3952	MD	denotes	may
T3232	3938-3948	NN	denotes	resistance
T3231	3934-3937	NNP	denotes	TMZ
T3230	3931-3933	IN	denotes	of
T3229	3922-3930	NN	denotes	Reversal
T3228	3920-3921	.	denotes	.
T3227	3919-3920	-RRB-	denotes	)
T3226	3915-3919	CD	denotes	2011
T3225	3913-3914	,	denotes	,
T3224	3910-3913	FW	denotes	al.
T3223	3907-3909	FW	denotes	et
T3222	3901-3906	NNP	denotes	Oliva
T3221	3900-3901	-LRB-	denotes	(
T3220	3892-3899	NNS	denotes	gliomas
T3219	3889-3891	IN	denotes	in
T3218	3878-3888	NN	denotes	resistance
T3217	3874-3877	NNP	denotes	TMZ
T3216	3871-3873	TO	denotes	to
T3215	3866-3870	NN	denotes	part
T3214	3863-3865	IN	denotes	in
T3213	3851-3862	VBZ	denotes	contributes
T3212	3843-3850	NN	denotes	oxidase
T3211	3841-3842	NN	denotes	c
T3210	3830-3840	NN	denotes	cytochrome
T3209	3827-3829	IN	denotes	by
T3208	3817-3826	VBN	denotes	regulated
T3207	3815-3816	-RRB-	denotes	)
T3206	3812-3815	NNP	denotes	ROS
T3205	3811-3812	-LRB-	denotes	(
T3204	3803-3810	NNS	denotes	species
T3203	3796-3802	NN	denotes	oxygen
T3202	3787-3795	JJ	denotes	reactive
T3201	3784-3786	IN	denotes	of
T3200	3773-3783	NN	denotes	production
T3199	3769-3772	DT	denotes	the
T3198	3760-3768	VB	denotes	suppress
T3197	3757-3759	TO	denotes	to
T3196	3748-3756	NN	denotes	coupling
T3195	3742-3747	NN	denotes	chain
T3194	3730-3741	JJ	denotes	respiratory
T3193	3716-3729	JJ	denotes	mitochondrial
T3192	3713-3715	IN	denotes	of
T3191	3700-3712	NNP	denotes	Upregulation
T3190	3698-3699	.	denotes	.
T3189	3697-3698	-RRB-	denotes	)
T3188	3693-3697	CD	denotes	2012
T3187	3691-3692	,	denotes	,
T3186	3688-3691	FW	denotes	al.
T3185	3685-3687	FW	denotes	et
T3184	3675-3684	NNP	denotes	Agnihotri
T3183	3674-3675	-LRB-	denotes	(
T3182	3663-3673	NN	denotes	resistance
T3181	3659-3662	NNP	denotes	TMZ
T3180	3655-3658	DT	denotes	the
T3179	3652-3654	IN	denotes	in
T3178	3639-3651	VBZ	denotes	participates
T3177	3634-3638	RB	denotes	also
T3176	3632-3633	,	denotes	,
T3175	3616-3632	JJ	denotes	N7-methylguanine
T3174	3612-3615	CC	denotes	and
T3173	3595-3611	JJ	denotes	N3-methyladenine
T3172	3587-3594	NNS	denotes	lesions
T3171	3577-3586	JJ	denotes	cytotoxic
T3170	3573-3576	DT	denotes	the
T3169	3565-3572	NNS	denotes	repairs
T3168	3559-3564	WDT	denotes	which
T3167	3557-3558	,	denotes	,
T3166	3556-3557	-RRB-	denotes	)
T3165	3552-3556	NNP	denotes	APNG
T3164	3551-3552	-LRB-	denotes	(
T3163	3521-3550	JJ	denotes	alkylpurine-DNA-N-glycosylase
T3162	3514-3520	NN	denotes	enzyme
T3161	3507-3513	NN	denotes	repair
T3160	3498-3506	NN	denotes	excision
T3159	3493-3497	NN	denotes	base
T3158	3489-3492	DT	denotes	The
T3157	3487-3488	.	denotes	.
T3156	3481-3487	NNS	denotes	tumors
T3155	3475-3480	NN	denotes	brain
T3154	3464-3474	JJ	denotes	high-grade
T3153	3460-3463	IN	denotes	for
T3152	3453-3459	NN	denotes	target
T3151	3441-3452	JJ	denotes	therapeutic
T3150	3439-3440	DT	denotes	a
T3149	3436-3438	IN	denotes	as
T3148	3425-3435	VBN	denotes	considered
T3147	3422-3424	VBZ	denotes	is
T3146	3413-3421	NN	denotes	integrin
T3145	3408-3412	JJ	denotes	α5β1
T3144	3406-3407	.	denotes	.
T3143	3405-3406	-RRB-	denotes	)
T3142	3401-3405	CD	denotes	2012
T3141	3399-3400	,	denotes	,
T3140	3396-3399	FW	denotes	al.
T3139	3393-3395	FW	denotes	et
T3138	3382-3392	NNP	denotes	Janouskova
T3137	3381-3382	-LRB-	denotes	(
T3136	3377-3380	NNP	denotes	TMZ
T3135	3374-3376	TO	denotes	to
T3134	3363-3373	NN	denotes	resistance
T3133	3358-3362	NN	denotes	cell
T3132	3351-3357	NN	denotes	glioma
T3131	3343-3350	VBZ	denotes	induces
T3130	3337-3342	NN	denotes	event
T3129	3333-3336	DT	denotes	the
T3128	3329-3332	CC	denotes	and
T3127	3327-3328	,	denotes	,
T3126	3318-3327	VBG	denotes	signaling
T3125	3314-3317	NN	denotes	p53
T3124	3304-3313	VBZ	denotes	regulates
T3123	3293-3303	RB	denotes	negatively
T3122	3284-3292	NN	denotes	integrin
T3121	3279-3283	JJ	denotes	α5β1
T3120	3277-3278	.	denotes	.
T3119	3265-3277	JJ	denotes	chemotherapy
T3118	3261-3264	CC	denotes	and
T3117	3248-3260	JJ	denotes	radiotherapy
T3111	3210-3213	DT	denotes	the
T3110	3207-3209	IN	denotes	in
T3109	3202-3206	NN	denotes	role
T3108	3200-3201	DT	denotes	a
T3107	3195-3199	VBP	denotes	play
T3106	3185-3194	NNS	denotes	Integrins
T3105	3183-3184	.	denotes	.
T3104	3182-3183	-RRB-	denotes	)
T3103	3178-3182	CD	denotes	2012
T3102	3176-3177	,	denotes	,
T3101	3173-3176	FW	denotes	al.
T3100	3170-3172	FW	denotes	et
T3099	3167-3169	NNP	denotes	Li
T3098	3166-3167	-LRB-	denotes	(
T3097	3160-3165	NNS	denotes	cells
T3096	3153-3159	NN	denotes	cancer
T3095	3149-3152	IN	denotes	for
T3094	3142-3148	NN	denotes	factor
T3093	3129-3141	JJ	denotes	pro-survival
T3092	3127-3128	DT	denotes	a
T3091	3124-3126	IN	denotes	as
T3090	3113-3123	VBN	denotes	considered
T3089	3110-3112	VBZ	denotes	is
T3088	3098-3109	NN	denotes	MicroRNA-21
T3087	3096-3097	.	denotes	.
T3086	3095-3096	-RRB-	denotes	)
T3085	3091-3095	CD	denotes	2010
T3084	3089-3090	,	denotes	,
T3083	3086-3089	FW	denotes	al.
T3082	3083-3085	FW	denotes	et
T3081	3079-3082	NNP	denotes	Shi
T3080	3078-3079	-LRB-	denotes	(
T3079	3068-3077	NN	denotes	apoptosis
T3078	3056-3067	JJ	denotes	TMZ-induced
T3077	3047-3055	VBG	denotes	blocking
T3076	3039-3046	RB	denotes	thereby
T3075	3037-3038	,	denotes	,
T3074	3029-3037	NN	denotes	activity
T3073	3019-3028	JJ	denotes	caspase-3
T3072	3015-3018	CC	denotes	and
T3071	3009-3014	NN	denotes	ratio
T3070	3006-3008	CD	denotes	-2
T3069	2999-3006	NNP	denotes	Bax/Bcl
T3068	2991-2998	VBZ	denotes	reduces
T3067	2979-2990	NN	denotes	microRNA-21
T3066	2965-2978	VBD	denotes	overexpressed
T3065	2963-2964	,	denotes	,
T3064	2951-2963	RB	denotes	Intriguingly
T3063	2949-2950	.	denotes	.
T3062	2941-2949	NN	denotes	survival
T3061	2933-2940	NN	denotes	patient
T3060	2926-2932	NN	denotes	cancer
T3059	2917-2925	VBZ	denotes	prolongs
T3058	2915-2916	,	denotes	,
T3360	4648-4658	NN	denotes	polyphenol
T3359	4640-4647	JJ	denotes	natural
T3358	4638-4639	DT	denotes	a
T3357	4636-4637	,	denotes	,
T3356	4625-4636	NNP	denotes	Resveratrol
T3355	4623-4624	.	denotes	.
T3354	4622-4623	-RRB-	denotes	)
T3353	4618-4622	CD	denotes	2012
T3352	4616-4617	,	denotes	,
T3351	4613-4616	FW	denotes	al.
T3350	4610-4612	FW	denotes	et
T3349	4603-4609	NNP	denotes	Nakada
T3348	4602-4603	-LRB-	denotes	(
T3347	4591-4601	NNS	denotes	mechanisms
T3346	4579-4590	JJ	denotes	independent
T3345	4578-4579	:	denotes	-
T3344	4575-4577	CC	denotes	or
T3343	4560-4574	NNP	denotes	MGMT-dependent
T3342	4552-4559	IN	denotes	through
T3341	4548-4551	NNP	denotes	TMZ
T3340	4545-4547	IN	denotes	of
T3339	4533-4544	NN	denotes	sensitivity
T3338	4529-4532	DT	denotes	the
T3337	4520-4528	VB	denotes	increase
T3336	4518-4519	-RRB-	denotes	)
T3335	4515-4518	NNP	denotes	VAP
T3334	4514-4515	-LRB-	denotes	(
T3333	4509-4513	NN	denotes	acid
T3057	2905-2915	NN	denotes	expression
T3056	2897-2904	NN	denotes	protein
T3055	2892-2896	NNP	denotes	MGMT
T3054	2885-2891	VBZ	denotes	blocks
T3053	2879-2884	WDT	denotes	which
T3052	2877-2878	,	denotes	,
T3051	2866-2877	NN	denotes	methylation
T3050	2857-2865	NN	denotes	promoter
T3049	2852-2856	NN	denotes	gene
T3048	2847-2851	NNP	denotes	MGMT
T3047	2844-2846	IN	denotes	in
T3046	2835-2843	NN	denotes	increase
T3045	2832-2834	DT	denotes	An
T3044	2830-2831	.	denotes	.
T3043	2829-2830	-RRB-	denotes	)
T3042	2825-2829	CD	denotes	2012
T3041	2823-2824	,	denotes	,
T3040	2820-2823	FW	denotes	al.
T3039	2817-2819	FW	denotes	et
T3038	2808-2816	NNP	denotes	Villalva
T3037	2807-2808	-LRB-	denotes	(
T3036	2791-2806	NN	denotes	differentiation
T3035	2788-2790	TO	denotes	to
T3034	2778-2787	VBN	denotes	committed
T3033	2772-2777	NNS	denotes	cells
T3032	2769-2771	IN	denotes	in
T3031	2760-2768	NN	denotes	promoter
T3030	2755-2759	NN	denotes	gene
T3029	2750-2754	NNP	denotes	MGMT
T3028	2747-2749	IN	denotes	of
T3027	2740-2746	NN	denotes	status
T3026	2728-2739	NN	denotes	methylation
T3025	2724-2727	DT	denotes	the
T3024	2719-2723	IN	denotes	with
T3023	2708-2718	VBN	denotes	associated
T3022	2694-2707	RB	denotes	significantly
T3021	2691-2693	VBZ	denotes	is
T3020	2687-2690	NNP	denotes	TMZ
T3019	2684-2686	TO	denotes	to
T3018	2672-2683	NN	denotes	Sensitivity
T3017	2670-2671	.	denotes	.
T3016	2664-2670	NN	denotes	system
T3015	2660-2663	NNP	denotes	MMR
T3014	2656-2659	DT	denotes	the
T3013	2653-2655	IN	denotes	of
T3012	2645-2652	NN	denotes	absence
T3011	2641-2644	DT	denotes	the
T3010	2638-2640	IN	denotes	in
T3009	2632-2637	VBZ	denotes	fails
T3008	2622-2631	VBG	denotes	signaling
T3007	2612-2621	JJ	denotes	apoptotic
T3006	2609-2611	IN	denotes	of
T3005	2598-2608	NN	denotes	initiation
T3004	2594-2597	DT	denotes	The
T3003	2592-2593	.	denotes	.
T3002	2591-2592	-RRB-	denotes	)
T3001	2587-2591	CD	denotes	2008
T3000	2585-2586	,	denotes	,
T2999	2582-2585	FW	denotes	al.
T2998	2579-2581	FW	denotes	et
T2997	2570-2578	NNP	denotes	Sarkaria
T2996	2568-2569	:	denotes	;
T2995	2564-2568	CD	denotes	2008
T2994	2562-2563	,	denotes	,
T2993	2559-2562	FW	denotes	al.
T2992	2556-2558	FW	denotes	et
T2991	2551-2555	NNP	denotes	Hegi
T2990	2549-2550	:	denotes	;
T2989	2545-2549	CD	denotes	2006
T2988	2543-2544	,	denotes	,
T2987	2540-2543	FW	denotes	al.
T2986	2537-2539	FW	denotes	et
T2985	2529-2536	NNP	denotes	Pollack
T2984	2528-2529	-LRB-	denotes	(
T2983	2522-2527	NNS	denotes	cases
T2982	2513-2521	JJ	denotes	clinical
T2981	2508-2512	JJ	denotes	many
T2980	2505-2507	IN	denotes	in
T2979	2494-2504	NN	denotes	resistance
T2978	2490-2493	NNP	denotes	TMZ
T2977	2487-2489	TO	denotes	to
T2976	2473-2486	RB	denotes	significantly
T2975	2461-2472	VBZ	denotes	contributes
T2974	2457-2460	NNP	denotes	MMR
T2973	2454-2456	IN	denotes	of
T2972	2449-2453	NN	denotes	loss
T2971	2446-2448	CC	denotes	or
T2970	2441-2445	NNP	denotes	MGMT
T2969	2438-2440	IN	denotes	of
T2968	2427-2437	NN	denotes	expression
T2967	2422-2426	NNP	denotes	High
T2966	2420-2421	.	denotes	.
T2965	2419-2420	-RRB-	denotes	)
T2964	2415-2419	CD	denotes	2007
T2963	2413-2414	,	denotes	,
T2962	2410-2413	FW	denotes	al.
T2961	2407-2409	FW	denotes	et
T2960	2402-2406	NNP	denotes	Roos
T2959	2400-2401	:	denotes	;
T2958	2396-2400	CD	denotes	2006
T2957	2394-2395	,	denotes	,
T2956	2386-2394	NNP	denotes	Edelmann
T2955	2382-2385	CC	denotes	and
T2954	2377-2381	NNP	denotes	Wang
T2953	2375-2376	:	denotes	;
T2952	2371-2375	CD	denotes	2004
T2951	2369-2370	,	denotes	,
T2950	2366-2369	FW	denotes	al.
T2949	2363-2365	FW	denotes	et
T2948	2354-2362	NNP	denotes	Caporali
T2947	2353-2354	-LRB-	denotes	(
T2946	2347-2352	NN	denotes	death
T2945	2342-2346	NN	denotes	cell
T2944	2332-2341	JJ	denotes	apoptotic
T2943	2329-2331	TO	denotes	to
T2942	2323-2328	VBZ	denotes	leads
T2941	2312-2322	RB	denotes	ultimately
T2940	2307-2311	WDT	denotes	that
T2939	2300-2306	NN	denotes	kinase
T2938	2292-2299	NN	denotes	protein
T2937	2279-2291	JJ	denotes	Rad3-related
T2936	2276-2278	CC	denotes	or
T2935	2267-2275	NNS	denotes	proteins
T2934	2265-2266	-RRB-	denotes	)
T2933	2262-2265	NNP	denotes	MMR
T2932	2261-2262	-LRB-	denotes	(
T2931	2244-2260	NN	denotes	repair-deficient
T2930	2235-2243	NN	denotes	mismatch
T2929	2232-2234	IN	denotes	of
T2928	2221-2231	NN	denotes	activation
T2927	2211-2220	NNS	denotes	initiates
T2926	2194-2210	JJ	denotes	O6-methylguanine
T2925	2192-2193	,	denotes	,
T2924	2186-2192	NN	denotes	repair
T2923	2181-2185	NNP	denotes	MGMT
T2922	2173-2180	IN	denotes	Without
T2921	2171-2172	.	denotes	.
T2920	2170-2171	-RRB-	denotes	)
T2919	2165-2170	JJ	denotes	2012b
T2918	2163-2164	,	denotes	,
T2917	2160-2163	FW	denotes	al.
T2916	2157-2159	FW	denotes	et
T2915	2151-2156	NNP	denotes	Zhang
T2914	2149-2150	:	denotes	;
T2913	2145-2149	CD	denotes	2009
T2912	2143-2144	,	denotes	,
T2911	2140-2143	FW	denotes	al.
T2910	2137-2139	FW	denotes	et
T2909	2127-2136	NNP	denotes	Fukushima
T2908	2125-2126	:	denotes	;
T2907	2121-2125	CD	denotes	2008
T2906	2119-2120	,	denotes	,
T2905	2116-2119	FW	denotes	al.
T2904	2113-2115	FW	denotes	et
T2903	2108-2112	NNP	denotes	Hegi
T2902	2106-2107	:	denotes	;
T2901	2102-2106	CD	denotes	2006
T2900	2100-2101	,	denotes	,
T2899	2097-2100	FW	denotes	al.
T2898	2094-2096	FW	denotes	et
T2897	2086-2093	NNP	denotes	Pollack
T2896	2085-2086	-LRB-	denotes	(
T2856	1855-1858	FW	denotes	al.
T2855	1852-1854	FW	denotes	et
T2854	1843-1851	NNP	denotes	Fujikane
T2853	1842-1843	-LRB-	denotes	(
T2852	1832-1841	NN	denotes	apoptosis
T2851	1817-1831	JJ	denotes	lesion-induced
T2850	1800-1816	JJ	denotes	O6-methylguanine
T2849	1796-1799	DT	denotes	the
T2848	1793-1795	IN	denotes	in
T2847	1780-1792	VBZ	denotes	participates
T2846	1775-1779	NN	denotes	gene
T2845	1773-1774	-RRB-	denotes	)
T2844	1765-1773	NNP	denotes	C1orf201
T2843	1764-1765	-LRB-	denotes	(
T2842	1758-1763	NNP	denotes	MAPO2
T2841	1756-1757	,	denotes	,
T2840	1752-1756	RB	denotes	Also
T2839	1750-1751	.	denotes	.
T2838	1749-1750	-RRB-	denotes	)
T2837	1745-1749	CD	denotes	2013
T2836	1743-1744	,	denotes	,
T2835	1740-1743	FW	denotes	al.
T2834	1737-1739	FW	denotes	et
T2833	1728-1736	NNP	denotes	Knizhnik
T2832	1727-1728	-LRB-	denotes	(
T2831	1721-1726	NNS	denotes	cells
T2830	1717-1720	NNP	denotes	GBM
T2829	1714-1716	IN	denotes	in
T2828	1704-1713	NN	denotes	apoptosis
T2827	1695-1703	JJ	denotes	eventual
T2826	1691-1694	DT	denotes	the
T2825	1685-1690	VB	denotes	block
T2824	1681-1684	MD	denotes	may
T2823	1677-1680	CC	denotes	and
T2822	1675-1676	,	denotes	,
T2821	1663-1675	JJ	denotes	pro-survival
T2820	1660-1662	VBZ	denotes	is
T2819	1650-1659	NN	denotes	autophagy
T2818	1638-1649	JJ	denotes	TMZ-induced
T2817	1633-1637	IN	denotes	that
T2816	1620-1632	VBD	denotes	demonstrated
T2815	1614-1619	NN	denotes	study
T2814	1607-1613	JJ	denotes	recent
T2813	1605-1606	DT	denotes	a
T2812	1603-1604	,	denotes	,
T2811	1596-1603	RB	denotes	However
T2810	1594-1595	.	denotes	.
T2809	1593-1594	-RRB-	denotes	)
T2808	1589-1593	CD	denotes	2010
T2807	1587-1588	,	denotes	,
T2806	1584-1587	FW	denotes	al.
T2805	1581-1583	FW	denotes	et
T2804	1576-1580	NNP	denotes	Voss
T2803	1575-1576	-LRB-	denotes	(
T3116	3245-3247	TO	denotes	to
T3115	3237-3244	NNS	denotes	cancers
T3114	3228-3236	JJ	denotes	advanced
T3113	3225-3227	IN	denotes	of
T3112	3214-3224	NN	denotes	resistance
T2802	1571-1574	NNP	denotes	TMZ
T2801	1568-1570	IN	denotes	of
T2800	1561-1567	NN	denotes	action
T2799	1557-1560	DT	denotes	the
T2798	1548-1556	VBZ	denotes	enhances
T2797	1544-1547	CC	denotes	and
T2796	1536-1543	NNS	denotes	gliomas
T2795	1533-1535	IN	denotes	in
T2794	1527-1532	NN	denotes	death
T2793	1516-1526	JJ	denotes	autophagic
T2792	1513-1515	TO	denotes	to
T2791	1507-1512	VBZ	denotes	leads
T2790	1498-1506	NN	denotes	gossypol
T2789	1497-1498	:	denotes	-
T2788	1496-1497	-RRB-	denotes	)
T2787	1495-1496	FW	denotes	−
T2786	1494-1495	-LRB-	denotes	(
T2785	1484-1493	NN	denotes	inhibitor
T2784	1474-1483	NN	denotes	pan-Bcl-2
T2783	1472-1473	DT	denotes	a
T2782	1469-1471	IN	denotes	by
T2781	1463-1468	NN	denotes	Bcl-2
T2780	1449-1462	JJ	denotes	antiapoptotic
T2779	1446-1448	IN	denotes	of
T2778	1435-1445	NN	denotes	inhibition
T2777	1433-1434	,	denotes	,
T2776	1429-1433	RB	denotes	Also
T2775	1427-1428	.	denotes	.
T2774	1426-1427	-RRB-	denotes	)
T2773	1422-1426	CD	denotes	2003
T2772	1420-1421	,	denotes	,
T2771	1417-1420	FW	denotes	al.
T2770	1414-1416	FW	denotes	et
T2769	1406-1413	NNP	denotes	Kanzawa
T2768	1405-1406	-LRB-	denotes	(
T2767	1399-1404	NN	denotes	death
T2766	1394-1398	NN	denotes	cell
T2765	1388-1393	VB	denotes	cause
T2764	1385-1387	TO	denotes	to
T2763	1383-1384	,	denotes	,
T2762	1374-1383	NN	denotes	apoptosis
T2761	1369-1373	IN	denotes	than
T2760	1362-1368	RB	denotes	rather
T2759	1360-1361	,	denotes	,
T2758	1351-1360	NN	denotes	autophagy
T2757	1343-1350	VB	denotes	trigger
T2756	1340-1342	TO	denotes	to
T2755	1334-1339	VBN	denotes	known
T2754	1331-1333	VBZ	denotes	is
T2753	1324-1330	NN	denotes	lesion
T2752	1307-1323	JJ	denotes	O6-methylguanine
T2751	1303-1306	DT	denotes	The
T2750	1301-1302	.	denotes	.
T2749	1300-1301	-RRB-	denotes	)
T2748	1295-1300	JJ	denotes	2012b
T2747	1293-1294	,	denotes	,
T2746	1290-1293	FW	denotes	al.
T2745	1287-1289	FW	denotes	et
T2744	1281-1286	NNP	denotes	Zhang
T2743	1279-1280	:	denotes	;
T2742	1275-1279	CD	denotes	2011
T2741	1273-1274	,	denotes	,
T2740	1270-1273	FW	denotes	al.
T2739	1267-1269	FW	denotes	et
T2738	1258-1266	NNP	denotes	Goellner
T2737	1257-1258	-LRB-	denotes	(
T2736	1240-1256	NNP	denotes	N7-methylguanine
T2735	1236-1239	CC	denotes	and
T2734	1234-1235	,	denotes	,
T2733	1218-1234	NNP	denotes	N3-methyladenine
T2732	1216-1217	,	denotes	,
T2731	1200-1216	NNP	denotes	O6-methylguanine
T2730	1190-1199	VBG	denotes	including
T2729	1188-1189	,	denotes	,
T2728	1181-1188	NNS	denotes	lesions
T2727	1177-1180	NNP	denotes	DNA
T2726	1174-1176	IN	denotes	of
T2725	1163-1173	NN	denotes	generation
T2724	1155-1162	VBZ	denotes	induces
T2723	1142-1154	NNP	denotes	Temozolomide
T2722	1140-1141	.	denotes	.
T2721	1139-1140	-RRB-	denotes	)
T2720	1134-1139	JJ	denotes	2012b
T2719	1132-1133	,	denotes	,
T2718	1129-1132	FW	denotes	al.
T2717	1126-1128	FW	denotes	et
T2716	1120-1125	NNP	denotes	Zhang
T2715	1118-1119	:	denotes	;
T2714	1114-1118	CD	denotes	2012
T2713	1112-1113	,	denotes	,
T2712	1109-1112	FW	denotes	al.
T2711	1106-1108	FW	denotes	et
T2710	1098-1105	NNP	denotes	Kohsaka
T2709	1096-1097	:	denotes	;
T2708	1092-1096	CD	denotes	2012
T2707	1090-1091	,	denotes	,
T2706	1087-1090	FW	denotes	al.
T2705	1084-1086	FW	denotes	et
T2704	1076-1083	NNP	denotes	Kitange
T2703	1074-1075	:	denotes	;
T2702	1070-1074	CD	denotes	2012
T2701	1068-1069	,	denotes	,
T2700	1060-1068	NNP	denotes	Bjerkvig
T2699	1056-1059	CC	denotes	and
T2698	1044-1055	NNP	denotes	Johannessen
T2697	1042-1043	:	denotes	;
T2696	1038-1042	CD	denotes	2012
T2695	1036-1037	,	denotes	,
T2694	1033-1036	FW	denotes	al.
T2693	1030-1032	FW	denotes	et
T2692	1022-1029	NNP	denotes	Happold
T2691	1020-1021	:	denotes	;
T2690	1016-1020	CD	denotes	2012
T2689	1014-1015	,	denotes	,
T2688	1011-1014	FW	denotes	al.
T2687	1008-1010	FW	denotes	et
T2686	1003-1007	NNP	denotes	Haar
T2685	1002-1003	-LRB-	denotes	(
T2684	995-1001	NNS	denotes	others
T2683	990-994	JJ	denotes	many
T2682	986-989	CC	denotes	and
T2681	984-985	,	denotes	,
T2680	978-984	NN	denotes	kinase
T2679	972-977	CD	denotes	STAT3
T2678	970-971	,	denotes	,
T2677	960-970	NN	denotes	transition
T2676	937-959	JJ	denotes	epithelial-mesenchymal
T2675	935-936	,	denotes	,
T2674	922-935	NN	denotes	deacetylation
T2673	914-921	NN	denotes	histone
T2672	912-913	,	denotes	,
T2671	905-912	NN	denotes	hypoxia
T2670	899-904	IN	denotes	under
T2669	893-898	NNS	denotes	cells
T2668	887-892	NN	denotes	tumor
T2667	885-886	,	denotes	,
T2666	879-885	NN	denotes	repair
T2665	872-878	NN	denotes	damage
T2664	868-871	NNP	denotes	DNA
T2663	866-867	,	denotes	,
T2662	860-866	NN	denotes	efflux
T2661	855-859	NN	denotes	drug
T2660	853-854	,	denotes	,
T2659	844-853	NNS	denotes	microRNAs
T2658	842-843	,	denotes	,
T2657	837-842	NNS	denotes	cells
T2656	832-836	NN	denotes	stem
T2655	825-831	NN	denotes	cancer
T2654	817-824	VB	denotes	include
T2653	813-816	MD	denotes	may
T2652	807-812	WDT	denotes	which
T2651	805-806	,	denotes	,
T2650	795-805	NN	denotes	resistance
T2649	791-794	NNP	denotes	TMZ
T2648	787-790	DT	denotes	the
T2647	784-786	IN	denotes	in
T2646	775-783	VBN	denotes	involved
T2645	771-774	VBP	denotes	are
T2644	760-770	NNS	denotes	mechanisms
T2643	751-759	JJ	denotes	Multiple
T2642	749-750	.	denotes	.
T2641	748-749	-RRB-	denotes	)
T2562	345-346	-LRB-	denotes	(
T2561	343-344	NN	denotes	%
T2560	340-343	CD	denotes	9.8
T2559	335-339	RB	denotes	only
T2558	332-334	VBZ	denotes	is
T2557	328-331	NNP	denotes	GBM
T2556	324-327	IN	denotes	for
T2555	319-323	NN	denotes	rate
T2554	310-318	NN	denotes	survival
T2553	303-309	JJ	denotes	5-year
T2552	295-302	JJ	denotes	overall
T2551	291-294	DT	denotes	the
T2550	287-290	CC	denotes	and
T2549	285-286	,	denotes	,
T2548	279-285	NNS	denotes	months
T2547	274-278	CD	denotes	14.6
T2546	271-273	VBZ	denotes	is
T2545	260-270	NN	denotes	expectancy
T2544	251-259	NN	denotes	survival
T2543	243-250	JJ	denotes	average
T2542	239-242	DT	denotes	the
T2541	235-238	CC	denotes	and
T2540	233-234	,	denotes	,
T2539	227-233	JJ	denotes	lethal
T2538	220-226	RB	denotes	highly
T2537	217-219	VBZ	denotes	is
T2536	215-216	-RRB-	denotes	)
T2535	212-215	NNP	denotes	GBM
T2534	211-212	-LRB-	denotes	(
T2533	198-210	NNP	denotes	Glioblastoma
T2532	196-197	.	denotes	.
T2531	195-196	-RRB-	denotes	)
T2530	191-195	CD	denotes	2012
T2529	189-190	,	denotes	,
T2528	186-189	FW	denotes	al.
T2527	183-185	FW	denotes	et
T2526	176-182	NNP	denotes	Silber
T2525	174-175	:	denotes	;
T2524	170-174	CD	denotes	2009
T2523	168-169	,	denotes	,
T2522	165-168	FW	denotes	al.
T2521	162-164	FW	denotes	et
T2520	156-161	NNP	denotes	Stupp
T2519	154-155	:	denotes	;
T2518	150-154	CD	denotes	2000
T2517	148-149	,	denotes	,
T2516	145-148	FW	denotes	al.
T2515	142-144	FW	denotes	et
T2514	133-141	NNP	denotes	Friedman
T2513	132-133	-LRB-	denotes	(
T2512	123-131	RB	denotes	annually
T2511	118-122	NNP	denotes	U.S.
T2510	114-117	DT	denotes	the
T2509	111-113	IN	denotes	in
T2895	2083-2084	-RRB-	denotes	)
T2894	2079-2083	NNP	denotes	MGMT
T2893	2078-2079	-LRB-	denotes	(
T2892	2060-2077	NN	denotes	methyltransferase
T2891	2039-2059	NNP	denotes	O6-methylguanine-DNA
T2890	2036-2038	IN	denotes	by
T2889	2029-2035	NN	denotes	repair
T2888	2022-2028	JJ	denotes	direct
T2887	2018-2021	IN	denotes	for
T2886	2008-2017	NN	denotes	substrate
T2885	2006-2007	DT	denotes	a
T2884	2003-2005	VBZ	denotes	is
T2883	1996-2002	NN	denotes	lesion
T2882	1979-1995	JJ	denotes	O6-methylguanine
T2881	1975-1978	DT	denotes	The
T2880	1973-1974	.	denotes	.
T2879	1964-1973	NN	denotes	autophagy
T2878	1961-1963	IN	denotes	in
T2877	1952-1960	VBN	denotes	involved
T2876	1949-1951	VBZ	denotes	is
T2875	1944-1948	NN	denotes	gene
T2874	1939-1943	DT	denotes	this
T2873	1931-1938	IN	denotes	whether
T2872	1920-1930	VBN	denotes	determined
T2871	1916-1919	RB	denotes	not
T2870	1913-1915	VBZ	denotes	is
T2869	1910-1912	PRP	denotes	It
T2868	1908-1909	.	denotes	.
T2867	1901-1908	NN	denotes	protein
T2866	1894-1900	NN	denotes	37-kDa
T2865	1888-1893	NN	denotes	novel
T2864	1886-1887	DT	denotes	a
T2863	1878-1885	VBZ	denotes	encodes
T2862	1873-1877	NN	denotes	gene
T2861	1867-1872	CD	denotes	MAPO2
T2860	1865-1866	.	denotes	.
T2859	1864-1865	-RRB-	denotes	)
T2858	1860-1864	CD	denotes	2012
T2857	1858-1859	,	denotes	,
T2508	102-110	NNS	denotes	patients
T2507	98-101	JJ	denotes	new
T2506	91-97	CD	denotes	12,500
T2505	82-90	VBZ	denotes	afflicts
T2504	71-81	JJ	denotes	multiforme
T2503	58-70	NNP	denotes	Glioblastoma
T2640	744-748	CD	denotes	2010
T2639	742-743	,	denotes	,
T2638	733-742	NNP	denotes	Nishikawa
T2637	731-732	:	denotes	;
T2636	727-731	CD	denotes	2000
T2635	725-726	,	denotes	,
T2634	722-725	FW	denotes	al.
T2633	719-721	FW	denotes	et
T2632	710-718	NNP	denotes	Friedman
T2631	709-710	-LRB-	denotes	(
T2630	707-708	-RRB-	denotes	)
T2629	704-707	NNP	denotes	TMZ
T2628	703-704	-LRB-	denotes	(
T2627	690-702	NN	denotes	temozolomide
T2626	684-689	NN	denotes	agent
T2625	673-683	NN	denotes	alkylating
T2624	658-672	JJ	denotes	monofunctional
T2623	654-657	DT	denotes	the
T2622	649-653	IN	denotes	with
T2621	639-648	NN	denotes	treatment
T2620	635-638	CC	denotes	and
T2619	633-634	,	denotes	,
T2618	624-633	NN	denotes	radiation
T2617	622-623	,	denotes	,
T2616	615-622	NN	denotes	surgery
T2615	605-614	NN	denotes	debulking
T2614	597-604	NN	denotes	maximum
T2613	588-596	VBZ	denotes	includes
T2612	581-587	RB	denotes	mainly
T2611	577-580	NNP	denotes	GBM
T2610	573-576	IN	denotes	for
T2609	565-572	NN	denotes	therapy
T2608	556-564	JJ	denotes	standard
T2607	548-555	JJ	denotes	current
T2606	544-547	DT	denotes	The
T2605	542-543	.	denotes	.
T2604	541-542	-RRB-	denotes	)
T2603	537-541	CD	denotes	2012
T2602	535-536	,	denotes	,
T2601	532-535	FW	denotes	al.
T2600	529-531	FW	denotes	et
T2599	521-528	NNP	denotes	Happold
T2598	519-520	:	denotes	;
T2597	515-519	CD	denotes	2012
T2596	513-514	,	denotes	,
T2595	510-513	FW	denotes	al.
T2594	507-509	FW	denotes	et
T2593	502-506	NNP	denotes	Haar
T2592	501-502	-LRB-	denotes	(
T2591	492-500	NNS	denotes	patients
T2590	489-491	IN	denotes	in
T2589	484-488	VBN	denotes	seen
T2588	473-483	RB	denotes	frequently
T2587	469-472	VBP	denotes	are
T2586	461-468	NN	denotes	relapse
T2585	454-460	NN	denotes	cancer
T2584	450-453	CC	denotes	and
T2583	439-449	NNS	denotes	modalities
T2582	427-438	JJ	denotes	therapeutic
T2581	419-426	JJ	denotes	current
T2580	416-418	TO	denotes	to
T2579	405-415	NN	denotes	resistance
T2578	402-404	IN	denotes	of
T2577	395-401	NNS	denotes	levels
T2576	390-394	JJ	denotes	High
T2575	388-389	.	denotes	.
T2574	387-388	-RRB-	denotes	)
T2573	383-387	CD	denotes	2009
T2572	381-382	,	denotes	,
T2571	378-381	FW	denotes	al.
T2570	375-377	FW	denotes	et
T2569	369-374	NNP	denotes	Stupp
T2568	367-368	:	denotes	;
T2567	363-367	CD	denotes	2000
T2566	361-362	,	denotes	,
T2565	358-361	FW	denotes	al.
T2564	355-357	FW	denotes	et
T2563	346-354	NNP	denotes	Friedman
R1576	T2518	T2516	npadvmod	2000,al.
R1577	T2519	T2516	punct	;,al.
R1578	T2520	T2522	compound	Stupp,al.
R1579	T2521	T2522	compound	et,al.
R1580	T2503	T2504	compound	Glioblastoma,multiforme
R1581	T2522	T2505	prep	al.,afflicts
R1582	T2504	T2505	nsubj	multiforme,afflicts
R1583	T2505	T2528	ccomp	afflicts,al.
R1584	T2523	T2522	punct	",",al.
R1585	T2506	T2508	nummod	"12,500",patients
R1586	T2524	T2522	npadvmod	2009,al.
R1587	T2507	T2508	amod	new,patients
R1588	T2508	T2505	dobj	patients,afflicts
R1589	T2509	T2508	prep	in,patients
R1590	T2510	T2511	det	the,U.S.
R1591	T2525	T2528	punct	;,al.
R1592	T2511	T2509	pobj	U.S.,in
R1593	T2512	T2505	advmod	annually,afflicts
R1594	T2526	T2528	compound	Silber,al.
R1595	T2527	T2528	compound	et,al.
R1596	T2528	T2528	ROOT	al.,al.
R1597	T2513	T2516	punct	(,al.
R1598	T2529	T2528	punct	",",al.
R1599	T2514	T2516	nmod	Friedman,al.
R1600	T2515	T2516	nmod	et,al.
R1601	T2530	T2528	npadvmod	2012,al.
R1602	T2516	T2522	compound	al.,al.
R1603	T2517	T2516	punct	",",al.
R1604	T2531	T2528	punct	),al.
R1605	T2532	T2528	punct	.,al.
R1606	T2533	T2537	nsubj	Glioblastoma,is
R1607	T2534	T2535	punct	(,GBM
R1608	T2570	T2571	compound	et,al.
R1609	T2571	T2558	attr	al.,is
R1610	T2535	T2533	appos	GBM,Glioblastoma
R1611	T2572	T2571	punct	",",al.
R1612	T2573	T2571	npadvmod	2009,al.
R1613	T2574	T2558	punct	),is
R1614	T2536	T2533	punct	),Glioblastoma
R1615	T2575	T2546	punct	.,is
R1616	T2576	T2577	amod	High,levels
R1617	T2537	T2537	ROOT	is,is
R1618	T2577	T2589	nsubjpass	levels,seen
R1619	T2578	T2577	prep	of,levels
R1620	T2579	T2578	pobj	resistance,of
R1621	T2538	T2539	advmod	highly,lethal
R1622	T2580	T2579	prep	to,resistance
R1623	T2581	T2583	amod	current,modalities
R1624	T2582	T2583	amod	therapeutic,modalities
R1625	T2539	T2537	acomp	lethal,is
R1626	T2583	T2580	pobj	modalities,to
R1627	T2584	T2583	cc	and,modalities
R1628	T2585	T2586	compound	cancer,relapse
R1629	T2586	T2583	conj	relapse,modalities
R1630	T2540	T2537	punct	",",is
R1631	T2587	T2589	auxpass	are,seen
R1632	T2588	T2589	advmod	frequently,seen
R1633	T2541	T2537	cc	and,is
R1634	T2589	T2601	ccomp	seen,al.
R1635	T2542	T2545	det	the,expectancy
R1636	T2590	T2589	prep	in,seen
R1637	T2543	T2545	amod	average,expectancy
R1638	T2591	T2590	pobj	patients,in
R1639	T2544	T2545	compound	survival,expectancy
R1640	T2545	T2546	nsubj	expectancy,is
R1641	T2592	T2595	punct	(,al.
R1642	T2546	T2537	conj	is,is
R1643	T2593	T2595	nmod	Haar,al.
R1644	T2594	T2595	nmod	et,al.
R1645	T2595	T2601	dep	al.,al.
R1646	T2547	T2548	nummod	14.6,months
R1647	T2596	T2595	punct	",",al.
R1648	T2597	T2595	npadvmod	2012,al.
R1649	T2548	T2546	attr	months,is
R1650	T2598	T2601	punct	;,al.
R1651	T2599	T2601	compound	Happold,al.
R1652	T2600	T2601	compound	et,al.
R1653	T2549	T2546	punct	",",is
R1654	T2601	T2601	ROOT	al.,al.
R1655	T2602	T2601	punct	",",al.
R1656	T2603	T2601	npadvmod	2012,al.
R1657	T2604	T2601	punct	),al.
R1658	T2605	T2601	punct	.,al.
R1659	T2606	T2609	det	The,therapy
R1660	T2550	T2546	cc	and,is
R1661	T2607	T2609	amod	current,therapy
R1662	T2608	T2609	amod	standard,therapy
R1663	T2609	T2613	nsubj	therapy,includes
R1664	T2551	T2555	det	the,rate
R1665	T2610	T2609	prep	for,therapy
R1666	T2611	T2610	pobj	GBM,for
R1667	T2612	T2613	advmod	mainly,includes
R1668	T2552	T2555	amod	overall,rate
R1669	T2613	T2613	ROOT	includes,includes
R1670	T2614	T2616	amod	maximum,surgery
R1671	T2615	T2616	compound	debulking,surgery
R1672	T2553	T2555	amod	5-year,rate
R1673	T2616	T2613	dobj	surgery,includes
R1674	T2617	T2616	punct	",",surgery
R1675	T2618	T2616	conj	radiation,surgery
R1676	T2554	T2555	compound	survival,rate
R1677	T2619	T2618	punct	",",radiation
R1678	T2620	T2618	cc	and,radiation
R1679	T2555	T2558	nsubj	rate,is
R1680	T2621	T2618	conj	treatment,radiation
R1681	T2622	T2616	prep	with,surgery
R1682	T2623	T2626	det	the,agent
R1683	T2624	T2626	amod	monofunctional,agent
R1684	T2556	T2555	prep	for,rate
R1685	T2625	T2626	amod	alkylating,agent
R1686	T2626	T2627	compound	agent,temozolomide
R1687	T2627	T2622	pobj	temozolomide,with
R1688	T2557	T2556	pobj	GBM,for
R1689	T2628	T2627	punct	(,temozolomide
R1690	T2629	T2627	appos	TMZ,temozolomide
R1691	T2558	T2546	conj	is,is
R1692	T2630	T2627	punct	),temozolomide
R1693	T2631	T2634	punct	(,al.
R1694	T2632	T2634	compound	Friedman,al.
R1695	T2559	T2560	advmod	only,9.8
R1696	T2633	T2634	nmod	et,al.
R1697	T2634	T2638	compound	al.,Nishikawa
R1698	T2560	T2561	nummod	9.8,%
R1699	T2635	T2634	punct	",",al.
R1700	T2636	T2634	dep	2000,al.
R1701	T2637	T2634	punct	;,al.
R1702	T2561	T2558	attr	%,is
R1703	T2638	T2616	appos	Nishikawa,surgery
R1704	T2639	T2638	punct	",",Nishikawa
R1705	T2640	T2638	npadvmod	2010,Nishikawa
R1706	T2641	T2638	punct	),Nishikawa
R1707	T2642	T2613	punct	.,includes
R1708	T2643	T2644	amod	Multiple,mechanisms
R1709	T2562	T2565	punct	(,al.
R1710	T2644	T2646	nsubjpass	mechanisms,involved
R1711	T2645	T2646	auxpass	are,involved
R1712	T2646	T2718	ccomp	involved,al.
R1713	T2647	T2646	prep	in,involved
R1714	T2563	T2565	compound	Friedman,al.
R1715	T2648	T2650	det	the,resistance
R1716	T2649	T2650	compound	TMZ,resistance
R1717	T2650	T2647	pobj	resistance,in
R1718	T2564	T2565	nmod	et,al.
R1719	T2651	T2650	punct	",",resistance
R1720	T2652	T2654	nsubj	which,include
R1721	T2653	T2654	aux	may,include
R1722	T2565	T2558	parataxis	al.,is
R1723	T2654	T2650	relcl	include,resistance
R1724	T2655	T2657	compound	cancer,cells
R1725	T2656	T2657	compound	stem,cells
R1726	T2566	T2565	punct	",",al.
R1727	T2657	T2654	dobj	cells,include
R1728	T2658	T2657	punct	",",cells
R1729	T2659	T2657	conj	microRNAs,cells
R1730	T2567	T2565	npadvmod	2000,al.
R1731	T2660	T2659	punct	",",microRNAs
R1732	T2661	T2662	compound	drug,efflux
R1733	T2662	T2659	conj	efflux,microRNAs
R1734	T2663	T2662	punct	",",efflux
R1735	T2568	T2558	punct	;,is
R1736	T2664	T2666	compound	DNA,repair
R1737	T2665	T2666	compound	damage,repair
R1738	T2666	T2662	conj	repair,efflux
R1739	T2569	T2571	compound	Stupp,al.
R1740	T2764	T2765	aux	to,cause
R1741	T2667	T2666	punct	",",repair
R1742	T2668	T2669	compound	tumor,cells
R1743	T2765	T2757	advcl	cause,trigger
R1744	T2669	T2659	conj	cells,microRNAs
R1745	T2766	T2767	compound	cell,death
R1746	T2670	T2654	prep	under,include
R1747	T2767	T2765	dobj	death,cause
R1748	T2671	T2670	pobj	hypoxia,under
R1749	T2768	T2765	punct	(,cause
R1750	T2769	T2771	compound	Kanzawa,al.
R1751	T2672	T2671	punct	",",hypoxia
R1752	T2770	T2771	nmod	et,al.
R1753	T2673	T2674	compound	histone,deacetylation
R1754	T2674	T2671	appos	deacetylation,hypoxia
R1755	T2675	T2674	punct	",",deacetylation
R1756	T2676	T2677	amod	epithelial-mesenchymal,transition
R1757	T2677	T2674	appos	transition,deacetylation
R1758	T2678	T2677	punct	",",transition
R1759	T2679	T2680	nummod	STAT3,kinase
R1760	T2771	T2765	advmod	al.,cause
R1761	T2680	T2677	conj	kinase,transition
R1762	T2681	T2680	punct	",",kinase
R1763	T2772	T2771	punct	",",al.
R1764	T2682	T2680	cc	and,kinase
R1765	T2683	T2684	amod	many,others
R1766	T2684	T2680	conj	others,kinase
R1767	T2773	T2771	npadvmod	2003,al.
R1768	T2685	T2684	punct	(,others
R1769	T2686	T2688	compound	Haar,al.
R1770	T2687	T2688	nmod	et,al.
R1771	T2774	T2771	punct	),al.
R1772	T2688	T2684	appos	al.,others
R1773	T2689	T2688	punct	",",al.
R1774	T2775	T2755	punct	.,known
R1775	T2690	T2688	npadvmod	2012,al.
R1776	T2691	T2684	punct	;,others
R1777	T2692	T2694	compound	Happold,al.
R1778	T2776	T2791	advmod	Also,leads
R1779	T2693	T2694	compound	et,al.
R1780	T2694	T2684	conj	al.,others
R1781	T2695	T2694	punct	",",al.
R1782	T2777	T2791	punct	",",leads
R1783	T2696	T2694	npadvmod	2012,al.
R1784	T2697	T2718	punct	;,al.
R1785	T2698	T2718	dep	Johannessen,al.
R1786	T2778	T2791	nsubj	inhibition,leads
R1787	T2699	T2698	cc	and,Johannessen
R1788	T2700	T2698	conj	Bjerkvig,Johannessen
R1789	T2701	T2700	punct	",",Bjerkvig
R1790	T2702	T2700	npadvmod	2012,Bjerkvig
R1791	T2779	T2778	prep	of,inhibition
R1792	T2703	T2700	punct	;,Bjerkvig
R1793	T2704	T2706	compound	Kitange,al.
R1794	T2705	T2706	compound	et,al.
R1795	T2780	T2781	amod	antiapoptotic,Bcl-2
R1796	T2706	T2700	conj	al.,Bjerkvig
R1797	T2707	T2706	punct	",",al.
R1798	T2708	T2706	npadvmod	2012,al.
R1799	T2781	T2779	pobj	Bcl-2,of
R1800	T2709	T2718	punct	;,al.
R1801	T2710	T2712	compound	Kohsaka,al.
R1802	T2711	T2712	compound	et,al.
R1803	T2782	T2778	prep	by,inhibition
R1804	T2712	T2718	ccomp	al.,al.
R1805	T2713	T2712	punct	",",al.
R1806	T2714	T2712	npadvmod	2012,al.
R1807	T2715	T2718	punct	;,al.
R1808	T2716	T2718	compound	Zhang,al.
R1809	T2717	T2718	nmod	et,al.
R1810	T2783	T2785	det	a,inhibitor
R1811	T2718	T2718	ROOT	al.,al.
R1812	T2719	T2720	punct	",",2012b
R1813	T2784	T2785	compound	pan-Bcl-2,inhibitor
R1814	T2720	T2718	amod	2012b,al.
R1815	T2785	T2782	pobj	inhibitor,by
R1816	T2721	T2720	punct	),2012b
R1817	T2722	T2718	punct	.,al.
R1818	T2723	T2724	nsubj	Temozolomide,induces
R1819	T2786	T2787	punct	(,−
R1820	T2724	T2746	ccomp	induces,al.
R1821	T2725	T2724	dobj	generation,induces
R1822	T2787	T2785	appos	−,inhibitor
R1823	T2726	T2725	prep	of,generation
R1824	T2727	T2728	compound	DNA,lesions
R1825	T2728	T2726	pobj	lesions,of
R1826	T2729	T2728	punct	",",lesions
R1827	T2788	T2787	punct	),−
R1828	T2730	T2728	prep	including,lesions
R1829	T2731	T2730	pobj	O6-methylguanine,including
R1830	T2789	T2791	punct	-,leads
R1831	T2732	T2731	punct	",",O6-methylguanine
R1832	T2733	T2731	conj	N3-methyladenine,O6-methylguanine
R1833	T2734	T2733	punct	",",N3-methyladenine
R1834	T2790	T2791	nsubj	gossypol,leads
R1835	T2735	T2733	cc	and,N3-methyladenine
R1836	T2736	T2733	conj	N7-methylguanine,N3-methyladenine
R1837	T2737	T2740	punct	(,al.
R1838	T2791	T2791	ROOT	leads,leads
R1839	T2738	T2740	compound	Goellner,al.
R1840	T2739	T2740	nmod	et,al.
R1841	T2740	T2731	appos	al.,O6-methylguanine
R1842	T2792	T2791	prep	to,leads
R1843	T2741	T2740	punct	",",al.
R1844	T2742	T2740	npadvmod	2011,al.
R1845	T2793	T2792	pobj	autophagic,to
R1846	T2743	T2746	punct	;,al.
R1847	T2744	T2746	compound	Zhang,al.
R1848	T2745	T2746	compound	et,al.
R1849	T2794	T2793	dobj	death,autophagic
R1850	T2746	T2746	ROOT	al.,al.
R1851	T2747	T2748	punct	",",2012b
R1852	T2795	T2793	prep	in,autophagic
R1853	T2748	T2746	amod	2012b,al.
R1854	T2796	T2795	pobj	gliomas,in
R1855	T2749	T2748	punct	),2012b
R1856	T2750	T2746	punct	.,al.
R1857	T2751	T2753	det	The,lesion
R1858	T2752	T2753	amod	O6-methylguanine,lesion
R1859	T2797	T2791	cc	and,leads
R1860	T2753	T2755	nsubjpass	lesion,known
R1861	T2754	T2755	auxpass	is,known
R1862	T2755	T2755	ROOT	known,known
R1863	T2798	T2791	conj	enhances,leads
R1864	T2756	T2757	aux	to,trigger
R1865	T2757	T2755	xcomp	trigger,known
R1866	T2758	T2757	dobj	autophagy,trigger
R1867	T2759	T2758	punct	",",autophagy
R1868	T2760	T2761	advmod	rather,than
R1869	T2799	T2800	det	the,action
R1870	T2761	T2757	prep	than,trigger
R1871	T2762	T2761	pobj	apoptosis,than
R1872	T2763	T2757	punct	",",trigger
R1873	T2800	T2798	dobj	action,enhances
R1874	T2801	T2800	prep	of,action
R1875	T2802	T2801	pobj	TMZ,of
R1876	T2803	T2806	punct	(,al.
R1877	T2861	T2863	dep	MAPO2,encodes
R1878	T2862	T2863	nsubj	gene,encodes
R1879	T2804	T2806	compound	Voss,al.
R1880	T2863	T2863	ROOT	encodes,encodes
R1881	T2864	T2867	det	a,protein
R1882	T2865	T2867	compound	novel,protein
R1883	T2805	T2806	nmod	et,al.
R1884	T2866	T2867	compound	37-kDa,protein
R1885	T2867	T2863	dobj	protein,encodes
R1886	T2806	T2800	appos	al.,action
R1887	T2868	T2863	punct	.,encodes
R1888	T2869	T2872	nsubjpass	It,determined
R1889	T2870	T2872	auxpass	is,determined
R1890	T2871	T2872	neg	not,determined
R1891	T2807	T2806	punct	",",al.
R1892	T2872	T2872	ROOT	determined,determined
R1893	T2873	T2876	mark	whether,is
R1894	T2874	T2875	det	this,gene
R1895	T2808	T2806	npadvmod	2010,al.
R1896	T2875	T2876	nsubj	gene,is
R1897	T2809	T2798	punct	),enhances
R1898	T2810	T2791	punct	.,leads
R1899	T2876	T2877	auxpass	is,involved
R1900	T2877	T2872	xcomp	involved,determined
R1901	T2811	T2816	advmod	However,demonstrated
R1902	T2878	T2877	prep	in,involved
R1903	T2879	T2878	pobj	autophagy,in
R1904	T2812	T2816	punct	",",demonstrated
R1905	T2880	T2872	punct	.,determined
R1906	T2881	T2883	det	The,lesion
R1907	T2882	T2883	amod	O6-methylguanine,lesion
R1908	T2883	T2884	nsubj	lesion,is
R1909	T2884	T2884	ROOT	is,is
R1910	T2885	T2886	det	a,substrate
R1911	T2813	T2815	det	a,study
R1912	T2886	T2884	attr	substrate,is
R1913	T2887	T2886	prep	for,substrate
R1914	T2888	T2889	amod	direct,repair
R1915	T2814	T2815	amod	recent,study
R1916	T2889	T2887	pobj	repair,for
R1917	T2815	T2816	nsubj	study,demonstrated
R1918	T2816	T2816	ROOT	demonstrated,demonstrated
R1919	T2890	T2889	prep	by,repair
R1920	T2817	T2820	mark	that,is
R1921	T2891	T2892	compound	O6-methylguanine-DNA,methyltransferase
R1922	T2892	T2890	pobj	methyltransferase,by
R1923	T2893	T2894	punct	(,MGMT
R1924	T2818	T2819	amod	TMZ-induced,autophagy
R1925	T2894	T2892	appos	MGMT,methyltransferase
R1926	T2895	T2884	punct	),is
R1927	T2819	T2820	nsubj	autophagy,is
R1928	T2896	T2899	punct	(,al.
R1929	T2897	T2899	compound	Pollack,al.
R1930	T2898	T2899	nmod	et,al.
R1931	T2820	T2816	ccomp	is,demonstrated
R1932	T2899	T2905	compound	al.,al.
R1933	T2900	T2899	punct	",",al.
R1934	T2901	T2899	npadvmod	2006,al.
R1935	T2821	T2820	acomp	pro-survival,is
R1936	T2902	T2899	punct	;,al.
R1937	T2903	T2905	compound	Hegi,al.
R1938	T2904	T2905	compound	et,al.
R1939	T2822	T2820	punct	",",is
R1940	T2905	T2905	ROOT	al.,al.
R1941	T2906	T2905	punct	",",al.
R1942	T2823	T2820	cc	and,is
R1943	T2824	T2825	aux	may,block
R1944	T2907	T2905	npadvmod	2008,al.
R1945	T2908	T2905	punct	;,al.
R1946	T2825	T2820	conj	block,is
R1947	T2909	T2911	compound	Fukushima,al.
R1948	T2910	T2911	nmod	et,al.
R1949	T2911	T2905	conj	al.,al.
R1950	T2826	T2828	det	the,apoptosis
R1951	T2912	T2911	punct	",",al.
R1952	T2913	T2911	npadvmod	2009,al.
R1953	T2827	T2828	amod	eventual,apoptosis
R1954	T2914	T2917	punct	;,al.
R1955	T2915	T2917	compound	Zhang,al.
R1956	T2916	T2917	nmod	et,al.
R1957	T2917	T2884	attr	al.,is
R1958	T2918	T2919	punct	",",2012b
R1959	T2828	T2825	dobj	apoptosis,block
R1960	T2919	T2917	amod	2012b,al.
R1961	T2920	T2919	punct	),2012b
R1962	T2921	T2884	punct	.,is
R1963	T2922	T2927	prep	Without,initiates
R1964	T2923	T2924	compound	MGMT,repair
R1965	T2829	T2825	prep	in,block
R1966	T2924	T2922	pobj	repair,Without
R1967	T2925	T2927	punct	",",initiates
R1968	T2926	T2927	nsubj	O6-methylguanine,initiates
R1969	T2927	T2927	ROOT	initiates,initiates
R1970	T2830	T2831	compound	GBM,cells
R1971	T2928	T2927	dobj	activation,initiates
R1972	T2929	T2928	prep	of,activation
R1973	T2930	T2929	pobj	mismatch,of
R1974	T2931	T2928	conj	repair-deficient,activation
R1975	T2831	T2829	pobj	cells,in
R1976	T2932	T2931	punct	(,repair-deficient
R1977	T2933	T2935	nmod	MMR,proteins
R1978	T2934	T2935	punct	),proteins
R1979	T2935	T2931	appos	proteins,repair-deficient
R1980	T2832	T2835	punct	(,al.
R1981	T2936	T2935	cc	or,proteins
R1982	T2937	T2939	amod	Rad3-related,kinase
R1983	T2833	T2835	compound	Knizhnik,al.
R1984	T2938	T2939	compound	protein,kinase
R1985	T2939	T2935	conj	kinase,proteins
R1986	T2940	T2942	nsubj	that,leads
R1987	T2834	T2835	nmod	et,al.
R1988	T2941	T2942	advmod	ultimately,leads
R1989	T2942	T2939	relcl	leads,kinase
R1990	T2943	T2942	prep	to,leads
R1991	T2835	T2825	parataxis	al.,block
R1992	T2944	T2946	amod	apoptotic,death
R1993	T2945	T2946	compound	cell,death
R1994	T2946	T2943	pobj	death,to
R1995	T2836	T2835	punct	",",al.
R1996	T2947	T2950	punct	(,al.
R1997	T2948	T2950	compound	Caporali,al.
R1998	T2949	T2950	nmod	et,al.
R1999	T2837	T2835	npadvmod	2013,al.
R2000	T2950	T2939	appos	al.,kinase
R2001	T2951	T2950	punct	",",al.
R2002	T2952	T2950	npadvmod	2004,al.
R2003	T2838	T2835	punct	),al.
R2004	T2953	T2927	punct	;,initiates
R2005	T2839	T2816	punct	.,demonstrated
R2006	T2954	T2927	conj	Wang,initiates
R2007	T2955	T2954	cc	and,Wang
R2008	T2956	T2954	conj	Edelmann,Wang
R2009	T2957	T2956	punct	",",Edelmann
R2010	T2840	T2847	advmod	Also,participates
R2011	T2841	T2847	punct	",",participates
R2012	T2842	T2847	nsubj	MAPO2,participates
R2013	T2958	T2954	npadvmod	2006,Wang
R2014	T2959	T2954	punct	;,Wang
R2015	T2843	T2842	punct	(,MAPO2
R2016	T2960	T2962	compound	Roos,al.
R2017	T2961	T2962	nmod	et,al.
R2018	T2844	T2842	appos	C1orf201,MAPO2
R2019	T2962	T2954	conj	al.,Wang
R2020	T2963	T2962	punct	",",al.
R2021	T2964	T2962	npadvmod	2007,al.
R2022	T2845	T2842	punct	),MAPO2
R2023	T2965	T2962	punct	),al.
R2024	T2966	T2927	punct	.,initiates
R2025	T2967	T2968	compound	High,expression
R2026	T2968	T2975	nsubj	expression,contributes
R2027	T2846	T2847	nsubj	gene,participates
R2028	T2969	T2968	prep	of,expression
R2029	T2970	T2969	pobj	MGMT,of
R2030	T2971	T2970	cc	or,MGMT
R2031	T2847	T2847	ROOT	participates,participates
R2032	T2972	T2968	conj	loss,expression
R2033	T2973	T2972	prep	of,loss
R2034	T2974	T2973	pobj	MMR,of
R2035	T2848	T2847	prep	in,participates
R2036	T2975	T2999	ccomp	contributes,al.
R2037	T2976	T2975	advmod	significantly,contributes
R2038	T2977	T2975	prep	to,contributes
R2039	T2849	T2852	det	the,apoptosis
R2040	T2978	T2979	compound	TMZ,resistance
R2041	T2979	T2977	pobj	resistance,to
R2042	T2980	T2975	prep	in,contributes
R2043	T2850	T2852	amod	O6-methylguanine,apoptosis
R2044	T2981	T2983	amod	many,cases
R2045	T2982	T2983	amod	clinical,cases
R2046	T2851	T2852	amod	lesion-induced,apoptosis
R2047	T2983	T2980	pobj	cases,in
R2048	T2984	T2987	punct	(,al.
R2049	T2985	T2987	compound	Pollack,al.
R2050	T2852	T2848	pobj	apoptosis,in
R2051	T2986	T2987	nmod	et,al.
R2052	T2853	T2856	punct	(,al.
R2053	T2854	T2856	nmod	Fujikane,al.
R2054	T2987	T2975	advcl	al.,contributes
R2055	T2988	T2987	punct	",",al.
R2056	T2855	T2856	nmod	et,al.
R2057	T2989	T2987	npadvmod	2006,al.
R2058	T2990	T2999	punct	;,al.
R2059	T2991	T2993	compound	Hegi,al.
R2060	T2992	T2993	nmod	et,al.
R2061	T2856	T2852	appos	al.,apoptosis
R2062	T2993	T2999	ccomp	al.,al.
R2063	T2994	T2993	punct	",",al.
R2064	T2857	T2856	punct	",",al.
R2065	T2995	T2993	npadvmod	2008,al.
R2066	T2858	T2856	npadvmod	2012,al.
R2067	T2996	T2999	punct	;,al.
R2068	T2997	T2999	compound	Sarkaria,al.
R2069	T2998	T2999	nmod	et,al.
R2070	T2859	T2856	punct	),al.
R2071	T2999	T2999	ROOT	al.,al.
R2072	T3000	T2999	punct	",",al.
R2073	T3001	T2999	npadvmod	2008,al.
R2074	T2860	T2847	punct	.,participates
R2075	T3002	T2999	punct	),al.
R2076	T3003	T2999	punct	.,al.
R2077	T3004	T3005	det	The,initiation
R2078	T3005	T3009	nsubj	initiation,fails
R2079	T3055	T3057	compound	MGMT,expression
R2080	T3006	T3005	prep	of,initiation
R2081	T3007	T3008	amod	apoptotic,signaling
R2082	T3008	T3006	pobj	signaling,of
R2083	T3009	T3009	ROOT	fails,fails
R2084	T3010	T3009	prep	in,fails
R2085	T3056	T3057	compound	protein,expression
R2086	T3011	T3012	det	the,absence
R2087	T3012	T3010	pobj	absence,in
R2088	T3013	T3012	prep	of,absence
R2089	T3057	T3054	dobj	expression,blocks
R2090	T3014	T3016	det	the,system
R2091	T3015	T3016	compound	MMR,system
R2092	T3016	T3013	pobj	system,of
R2093	T3058	T3059	punct	",",prolongs
R2094	T3017	T3009	punct	.,fails
R2095	T3018	T3023	nsubjpass	Sensitivity,associated
R2096	T3019	T3018	prep	to,Sensitivity
R2097	T3059	T3059	ROOT	prolongs,prolongs
R2098	T3020	T3019	pobj	TMZ,to
R2099	T3060	T3062	compound	cancer,survival
R2100	T3061	T3062	compound	patient,survival
R2101	T3021	T3023	auxpass	is,associated
R2102	T3022	T3023	advmod	significantly,associated
R2103	T3062	T3059	dobj	survival,prolongs
R2104	T3023	T3023	ROOT	associated,associated
R2105	T3024	T3023	prep	with,associated
R2106	T3025	T3027	det	the,status
R2107	T3026	T3027	amod	methylation,status
R2108	T3027	T3024	pobj	status,with
R2109	T3028	T3027	prep	of,status
R2110	T3063	T3059	punct	.,prolongs
R2111	T3029	T3031	compound	MGMT,promoter
R2112	T3030	T3031	compound	gene,promoter
R2113	T3031	T3028	pobj	promoter,of
R2114	T3064	T3068	advmod	Intriguingly,reduces
R2115	T3032	T3027	prep	in,status
R2116	T3033	T3032	pobj	cells,in
R2117	T3065	T3068	punct	",",reduces
R2118	T3034	T3033	acl	committed,cells
R2119	T3035	T3034	prep	to,committed
R2120	T3036	T3035	pobj	differentiation,to
R2121	T3066	T3067	amod	overexpressed,microRNA-21
R2122	T3037	T3040	punct	(,al.
R2123	T3038	T3040	compound	Villalva,al.
R2124	T3039	T3040	nmod	et,al.
R2125	T3067	T3068	nsubj	microRNA-21,reduces
R2126	T3040	T3027	appos	al.,status
R2127	T3041	T3040	punct	",",al.
R2128	T3042	T3040	npadvmod	2012,al.
R2129	T3068	T3068	ROOT	reduces,reduces
R2130	T3043	T3023	punct	),associated
R2131	T3044	T3023	punct	.,associated
R2132	T3045	T3046	det	An,increase
R2133	T3069	T3071	nmod	Bax/Bcl,ratio
R2134	T3046	T3059	nsubj	increase,prolongs
R2135	T3047	T3046	prep	in,increase
R2136	T3048	T3051	compound	MGMT,methylation
R2137	T3070	T3069	nummod	-2,Bax/Bcl
R2138	T3049	T3050	compound	gene,promoter
R2139	T3050	T3051	compound	promoter,methylation
R2140	T3051	T3047	pobj	methylation,in
R2141	T3071	T3068	dobj	ratio,reduces
R2142	T3052	T3051	punct	",",methylation
R2143	T3053	T3054	nsubj	which,blocks
R2144	T3054	T3051	relcl	blocks,methylation
R2145	T3072	T3071	cc	and,ratio
R2146	T3073	T3074	amod	caspase-3,activity
R2147	T3074	T3071	conj	activity,ratio
R2148	T3152	T3149	pobj	target,as
R2149	T3153	T3152	prep	for,target
R2150	T3075	T3068	punct	",",reduces
R2151	T3154	T3156	amod	high-grade,tumors
R2152	T3155	T3156	compound	brain,tumors
R2153	T3076	T3077	advmod	thereby,blocking
R2154	T3156	T3153	pobj	tumors,for
R2155	T3157	T3148	punct	.,considered
R2156	T3158	T3162	det	The,enzyme
R2157	T3159	T3162	amod	base,enzyme
R2158	T3160	T3162	compound	excision,enzyme
R2159	T3161	T3162	compound	repair,enzyme
R2160	T3162	T3178	nsubj	enzyme,participates
R2161	T3077	T3068	advcl	blocking,reduces
R2162	T3163	T3162	amod	alkylpurine-DNA-N-glycosylase,enzyme
R2163	T3164	T3165	punct	(,APNG
R2164	T3165	T3163	appos	APNG,alkylpurine-DNA-N-glycosylase
R2165	T3078	T3079	amod	TMZ-induced,apoptosis
R2166	T3166	T3165	punct	),APNG
R2167	T3167	T3163	punct	",",alkylpurine-DNA-N-glycosylase
R2168	T3079	T3077	dobj	apoptosis,blocking
R2169	T3168	T3169	nsubj	which,repairs
R2170	T3080	T3083	punct	(,al.
R2171	T3169	T3163	relcl	repairs,alkylpurine-DNA-N-glycosylase
R2172	T3170	T3172	det	the,lesions
R2173	T3081	T3083	compound	Shi,al.
R2174	T3171	T3172	amod	cytotoxic,lesions
R2175	T3172	T3169	dobj	lesions,repairs
R2176	T3173	T3169	advmod	N3-methyladenine,repairs
R2177	T3082	T3083	nmod	et,al.
R2178	T3174	T3173	cc	and,N3-methyladenine
R2179	T3083	T3083	ROOT	al.,al.
R2180	T3175	T3173	conj	N7-methylguanine,N3-methyladenine
R2181	T3176	T3178	punct	",",participates
R2182	T3084	T3083	punct	",",al.
R2183	T3177	T3178	advmod	also,participates
R2184	T3178	T3178	ROOT	participates,participates
R2185	T3179	T3178	prep	in,participates
R2186	T3085	T3083	npadvmod	2010,al.
R2187	T3180	T3182	det	the,resistance
R2188	T3181	T3182	compound	TMZ,resistance
R2189	T3182	T3179	pobj	resistance,in
R2190	T3086	T3083	punct	),al.
R2191	T3183	T3186	punct	(,al.
R2192	T3184	T3186	nmod	Agnihotri,al.
R2193	T3185	T3186	nmod	et,al.
R2194	T3087	T3083	punct	.,al.
R2195	T3186	T3178	dep	al.,participates
R2196	T3187	T3186	punct	",",al.
R2197	T3188	T3186	npadvmod	2012,al.
R2198	T3088	T3090	nsubjpass	MicroRNA-21,considered
R2199	T3189	T3186	punct	),al.
R2200	T3190	T3178	punct	.,participates
R2201	T3191	T3191	ROOT	Upregulation,Upregulation
R2202	T3089	T3090	auxpass	is,considered
R2203	T3192	T3191	prep	of,Upregulation
R2204	T3193	T3196	amod	mitochondrial,coupling
R2205	T3090	T3090	ROOT	considered,considered
R2206	T3194	T3195	amod	respiratory,chain
R2207	T3195	T3196	compound	chain,coupling
R2208	T3196	T3192	pobj	coupling,of
R2209	T3091	T3090	prep	as,considered
R2210	T3092	T3094	det	a,factor
R2211	T3197	T3198	aux	to,suppress
R2212	T3198	T3191	advcl	suppress,Upregulation
R2213	T3093	T3094	amod	pro-survival,factor
R2214	T3199	T3200	det	the,production
R2215	T3200	T3198	dobj	production,suppress
R2216	T3094	T3091	pobj	factor,as
R2217	T3201	T3200	prep	of,production
R2218	T3202	T3204	amod	reactive,species
R2219	T3203	T3204	compound	oxygen,species
R2220	T3095	T3094	prep	for,factor
R2221	T3204	T3201	pobj	species,of
R2222	T3205	T3208	punct	(,regulated
R2223	T3206	T3208	dep	ROS,regulated
R2224	T3096	T3097	compound	cancer,cells
R2225	T3207	T3208	punct	),regulated
R2226	T3097	T3095	pobj	cells,for
R2227	T3208	T3198	advcl	regulated,suppress
R2228	T3098	T3101	punct	(,al.
R2229	T3209	T3208	agent	by,regulated
R2230	T3210	T3212	compound	cytochrome,oxidase
R2231	T3211	T3212	compound	c,oxidase
R2232	T3099	T3101	compound	Li,al.
R2233	T3212	T3209	pobj	oxidase,by
R2234	T3213	T3208	punct	contributes,regulated
R2235	T3100	T3101	nmod	et,al.
R2236	T3214	T3213	prep	in,contributes
R2237	T3215	T3214	pobj	part,in
R2238	T3216	T3215	prep	to,part
R2239	T3101	T3094	appos	al.,factor
R2240	T3217	T3218	compound	TMZ,resistance
R2241	T3218	T3216	pobj	resistance,to
R2242	T3219	T3218	prep	in,resistance
R2243	T3102	T3101	punct	",",al.
R2244	T3220	T3219	pobj	gliomas,in
R2245	T3221	T3224	punct	(,al.
R2246	T3222	T3224	compound	Oliva,al.
R2247	T3103	T3101	npadvmod	2012,al.
R2248	T3223	T3224	nmod	et,al.
R2249	T3224	T3208	dep	al.,regulated
R2250	T3104	T3101	punct	),al.
R2251	T3225	T3224	punct	",",al.
R2252	T3226	T3224	npadvmod	2011,al.
R2253	T3227	T3224	punct	),al.
R2254	T3105	T3090	punct	.,considered
R2255	T3228	T3191	punct	.,Upregulation
R2256	T3229	T3235	nsubjpass	Reversal,achieved
R2257	T3230	T3229	prep	of,Reversal
R2258	T3231	T3230	pobj	TMZ,of
R2259	T3232	T3235	nsubjpass	resistance,achieved
R2260	T3233	T3235	aux	may,achieved
R2261	T3106	T3107	nsubj	Integrins,play
R2262	T3234	T3235	auxpass	be,achieved
R2263	T3235	T3235	ROOT	achieved,achieved
R2264	T3236	T3235	agent	by,achieved
R2265	T3107	T3107	ROOT	play,play
R2266	T3237	T3238	compound	MGMT,pseudosubstrates
R2267	T3238	T3236	pobj	pseudosubstrates,by
R2268	T3239	T3238	punct	",",pseudosubstrates
R2269	T3108	T3109	det	a,role
R2270	T3240	T3238	conj	O6-benzylguanine,pseudosubstrates
R2271	T3241	T3240	cc	and,O6-benzylguanine
R2272	T3109	T3107	dobj	role,play
R2273	T3242	T3240	conj	lomeguatrib,O6-benzylguanine
R2274	T3243	T3244	aux	to,sensitize
R2275	T3244	T3235	xcomp	sensitize,achieved
R2276	T3245	T3244	dobj	tumors,sensitize
R2277	T3110	T3109	prep	in,role
R2278	T3246	T3244	prep	to,sensitize
R2279	T3111	T3112	det	the,resistance
R2280	T3247	T3246	pobj	TMZ,to
R2281	T3112	T3110	pobj	resistance,in
R2282	T3113	T3112	prep	of,resistance
R2283	T3248	T3251	punct	(,al.
R2284	T3114	T3115	amod	advanced,cancers
R2285	T3115	T3113	pobj	cancers,of
R2286	T3249	T3251	compound	Zhang,al.
R2287	T3250	T3251	nmod	et,al.
R2288	T3116	T3117	aux	to,radiotherapy
R2289	T3251	T3246	parataxis	al.,to
R2290	T3252	T3251	punct	",",al.
R2291	T3253	T3251	amod	2012b,al.
R2292	T3117	T3115	relcl	radiotherapy,cancers
R2293	T3254	T3251	punct	),al.
R2294	T3255	T3235	punct	.,achieved
R2295	T3118	T3117	cc	and,radiotherapy
R2296	T3119	T3117	conj	chemotherapy,radiotherapy
R2297	T3256	T3261	nsubj	Methoxyamine-blocker,contributes
R2298	T3120	T3107	punct	.,play
R2299	T3257	T3256	prep	of,Methoxyamine-blocker
R2300	T3258	T3260	compound	base,repair
R2301	T3259	T3260	compound	excision,repair
R2302	T3121	T3122	amod	α5β1,integrin
R2303	T3260	T3257	pobj	repair,of
R2304	T3261	T3261	ROOT	contributes,contributes
R2305	T3262	T3261	advmod	significantly,contributes
R2306	T3122	T3124	nsubj	integrin,regulates
R2307	T3263	T3261	prep	to,contributes
R2308	T3264	T3265	compound	TMZ,cytotoxicity
R2309	T3265	T3263	pobj	cytotoxicity,to
R2310	T3266	T3271	advmod	particularly,repaired
R2311	T3267	T3271	advmod	when,repaired
R2312	T3268	T3269	amod	O6-methylguanine,adducts
R2313	T3123	T3124	advmod	negatively,regulates
R2314	T3269	T3271	nsubjpass	adducts,repaired
R2315	T3270	T3271	auxpass	are,repaired
R2316	T3271	T3261	advcl	repaired,contributes
R2317	T3124	T3124	ROOT	regulates,regulates
R2318	T3272	T3271	cc	or,repaired
R2319	T3273	T3271	conj	tolerated,repaired
R2320	T3274	T3283	punct	(,al.
R2321	T3275	T3277	nmod	Goellner,al.
R2322	T3125	T3124	dobj	p53,regulates
R2323	T3276	T3277	nmod	et,al.
R2324	T3277	T3283	ccomp	al.,al.
R2325	T3126	T3125	acl	signaling,p53
R2326	T3278	T3277	punct	",",al.
R2327	T3279	T3277	npadvmod	2011,al.
R2328	T3280	T3283	punct	;,al.
R2329	T3127	T3124	punct	",",regulates
R2330	T3281	T3283	compound	Zhang,al.
R2331	T3282	T3283	nmod	et,al.
R2332	T3283	T3283	ROOT	al.,al.
R2333	T3128	T3124	cc	and,regulates
R2334	T3284	T3285	punct	",",2012b
R2335	T3285	T3283	amod	2012b,al.
R2336	T3286	T3285	punct	),2012b
R2337	T3129	T3130	det	the,event
R2338	T3287	T3261	punct	.,contributes
R2339	T3130	T3131	nsubj	event,induces
R2340	T3288	T3289	amod	Dual,targeting
R2341	T3131	T3124	conj	induces,regulates
R2342	T3132	T3134	amod	glioma,resistance
R2343	T3289	T3301	nsubj	targeting,reverse
R2344	T3290	T3289	prep	of,targeting
R2345	T3291	T3293	compound	base,repair
R2346	T3133	T3134	compound	cell,resistance
R2347	T3292	T3293	compound	excision,repair
R2348	T3293	T3290	pobj	repair,of
R2349	T3134	T3131	dobj	resistance,induces
R2350	T3294	T3293	cc	and,repair
R2351	T3295	T3299	nmod	NAD,biosynthesis
R2352	T3296	T3297	punct	(,+
R2353	T3135	T3134	prep	to,resistance
R2354	T3297	T3295	parataxis	+,NAD
R2355	T3298	T3299	punct	),biosynthesis
R2356	T3299	T3293	conj	biosynthesis,repair
R2357	T3300	T3301	aux	may,reverse
R2358	T3136	T3135	pobj	TMZ,to
R2359	T3301	T3301	ROOT	reverse,reverse
R2360	T3302	T3303	compound	TMZ,resistance
R2361	T3303	T3301	dobj	resistance,reverse
R2362	T3304	T3301	prep	in,reverse
R2363	T3305	T3304	pobj	patients,in
R2364	T3306	T3305	prep	with,patients
R2365	T3137	T3140	punct	(,al.
R2366	T3307	T3310	amod	resistant,GBM
R2367	T3308	T3307	cc	and,resistant
R2368	T3309	T3307	conj	recurrent,resistant
R2369	T3138	T3140	nmod	Janouskova,al.
R2370	T3310	T3306	pobj	GBM,with
R2371	T3311	T3310	punct	(,GBM
R2372	T3312	T3314	nmod	Goellner,al.
R2373	T3139	T3140	nmod	et,al.
R2374	T3313	T3314	nmod	et,al.
R2375	T3314	T3301	dep	al.,reverse
R2376	T3140	T3134	appos	al.,resistance
R2377	T3141	T3140	punct	",",al.
R2378	T3315	T3314	punct	",",al.
R2379	T3142	T3140	npadvmod	2012,al.
R2380	T3316	T3314	npadvmod	2011,al.
R2381	T3317	T3314	punct	),al.
R2382	T3318	T3301	punct	.,reverse
R2383	T3319	T3337	nsubj	Interferon-β,increase
R2384	T3143	T3131	punct	),induces
R2385	T3320	T3321	punct	(,IFN-β
R2386	T3321	T3319	appos	IFN-β,Interferon-β
R2387	T3322	T3321	punct	),IFN-β
R2388	T3144	T3124	punct	.,regulates
R2389	T3323	T3319	punct	",",Interferon-β
R2390	T3324	T3319	appos	levetiracetam,Interferon-β
R2391	T3325	T3326	punct	(,LEV
R2392	T3145	T3146	amod	α5β1,integrin
R2393	T3326	T3324	appos	LEV,levetiracetam
R2394	T3327	T3326	punct	),LEV
R2395	T3328	T3324	punct	",",levetiracetam
R2396	T3146	T3148	nsubjpass	integrin,considered
R2397	T3329	T3324	conj	resveratrol,levetiracetam
R2398	T3330	T3329	punct	",",resveratrol
R2399	T3331	T3329	cc	and,resveratrol
R2400	T3147	T3148	auxpass	is,considered
R2401	T3332	T3333	amod	valproic,acid
R2402	T3333	T3329	conj	acid,resveratrol
R2403	T3334	T3333	punct	(,acid
R2404	T3335	T3337	nsubj	VAP,increase
R2405	T3148	T3148	ROOT	considered,considered
R2406	T3336	T3337	punct	),increase
R2407	T3337	T3337	ROOT	increase,increase
R2408	T3149	T3148	prep	as,considered
R2409	T3338	T3339	det	the,sensitivity
R2410	T3339	T3337	dobj	sensitivity,increase
R2411	T3340	T3339	prep	of,sensitivity
R2412	T3341	T3340	pobj	TMZ,of
R2413	T3342	T3337	prep	through,increase
R2414	T3150	T3152	det	a,target
R2415	T3343	T3342	pobj	MGMT-dependent,through
R2416	T3344	T3343	cc	or,MGMT-dependent
R2417	T3345	T3346	punct	-,independent
R2418	T3151	T3152	amod	therapeutic,target
R2419	T3443	T3442	prep	in,failure
R2420	T3346	T3347	amod	independent,mechanisms
R2421	T3347	T3343	conj	mechanisms,MGMT-dependent
R2422	T3348	T3347	punct	(,mechanisms
R2423	T3444	T3445	compound	TMZ,treatment
R2424	T3349	T3351	compound	Nakada,al.
R2425	T3350	T3351	nmod	et,al.
R2426	T3351	T3347	appos	al.,mechanisms
R2427	T3445	T3443	pobj	treatment,in
R2428	T3352	T3351	punct	",",al.
R2429	T3353	T3351	npadvmod	2012,al.
R2430	T3446	T3437	punct	.,are
R2431	T3354	T3347	punct	),mechanisms
R2432	T3447	T3448	det	The,concept
R2433	T3355	T3337	punct	.,increase
R2434	T3356	T3362	nsubj	Resveratrol,reverses
R2435	T3357	T3356	punct	",",Resveratrol
R2436	T3448	T3478	nsubjpass	concept,al.
R2437	T3358	T3360	det	a,polyphenol
R2438	T3359	T3360	amod	natural,polyphenol
R2439	T3360	T3356	appos	polyphenol,Resveratrol
R2440	T3361	T3356	punct	",",Resveratrol
R2441	T3449	T3448	prep	of,concept
R2442	T3362	T3362	ROOT	reverses,reverses
R2443	T3363	T3364	compound	TMZ,resistance
R2444	T3450	T3452	compound	cancer,cell
R2445	T3364	T3362	dobj	resistance,reverses
R2446	T3365	T3362	prep	via,reverses
R2447	T3366	T3368	det	an,mechanism
R2448	T3451	T3452	compound	stem,cell
R2449	T3367	T3368	amod	NF-κB-dependent,mechanism
R2450	T3368	T3365	pobj	mechanism,via
R2451	T3369	T3368	punct	(,mechanism
R2452	T3452	T3453	compound	cell,survival
R2453	T3370	T3372	compound	Huang,al.
R2454	T3371	T3372	nmod	et,al.
R2455	T3453	T3449	pobj	survival,of
R2456	T3372	T3368	appos	al.,mechanism
R2457	T3373	T3372	punct	",",al.
R2458	T3374	T3372	npadvmod	2012,al.
R2459	T3454	T3448	prep	from,concept
R2460	T3375	T3368	punct	),mechanism
R2461	T3376	T3362	punct	.,reverses
R2462	T3377	T3378	nummod	STAT3,inhibitor
R2463	T3378	T3384	nmod	inhibitor,efficacy
R2464	T3379	T3378	cc	or,inhibitor
R2465	T3380	T3382	nummod	STAT3,potentiates
R2466	T3381	T3382	amod	knockdown,potentiates
R2467	T3455	T3454	pobj	treatment,from
R2468	T3382	T3378	conj	potentiates,inhibitor
R2469	T3383	T3384	compound	TMZ,efficacy
R2470	T3384	T3384	ROOT	efficacy,efficacy
R2471	T3456	T3448	prep	with,concept
R2472	T3385	T3384	prep	in,efficacy
R2473	T3386	T3389	amod	resistant,lines
R2474	T3457	T3456	pobj	TMZ,with
R2475	T3387	T3389	nmod	GBM,lines
R2476	T3388	T3389	compound	cell,lines
R2477	T3389	T3385	pobj	lines,in
R2478	T3458	T3457	cc	and,TMZ
R2479	T3390	T3389	punct	(,lines
R2480	T3391	T3393	compound	Kohsaka,al.
R2481	T3392	T3393	nmod	et,al.
R2482	T3459	T3461	amod	other,drugs
R2483	T3393	T3389	appos	al.,lines
R2484	T3460	T3461	amod	chemotherapeutic,drugs
R2485	T3394	T3393	punct	",",al.
R2486	T3461	T3457	conj	drugs,TMZ
R2487	T3395	T3393	npadvmod	2012,al.
R2488	T3396	T3389	punct	),lines
R2489	T3462	T3463	aux	has,been
R2490	T3397	T3384	punct	.,efficacy
R2491	T3398	T3399	compound	Intratumoral,hypoxia
R2492	T3399	T3400	nsubj	hypoxia,is
R2493	T3463	T3478	auxpass	been,al.
R2494	T3400	T3400	ROOT	is,is
R2495	T3401	T3400	acomp	common,is
R2496	T3464	T3465	advmod	more,complicated
R2497	T3402	T3400	prep	in,is
R2498	T3403	T3402	pobj	GBMs,in
R2499	T3465	T3478	ccomp	complicated,al.
R2500	T3404	T3400	cc	and,is
R2501	T3405	T3407	aux	may,associated
R2502	T3406	T3407	auxpass	be,associated
R2503	T3466	T3468	mark	than,thought
R2504	T3407	T3400	conj	associated,is
R2505	T3408	T3407	prep	with,associated
R2506	T3409	T3410	det	the,development
R2507	T3467	T3468	advmod	previously,thought
R2508	T3410	T3408	pobj	development,with
R2509	T3411	T3410	prep	of,development
R2510	T3412	T3413	compound	TMZ,resistance
R2511	T3413	T3411	pobj	resistance,of
R2512	T3414	T3400	punct	.,is
R2513	T3415	T3416	amod	Induced,hyperoxia
R2514	T3468	T3465	advcl	thought,complicated
R2515	T3416	T3419	nsubjpass	hyperoxia,utilized
R2516	T3417	T3419	aux	can,utilized
R2517	T3418	T3419	auxpass	be,utilized
R2518	T3419	T3419	ROOT	utilized,utilized
R2519	T3469	T3465	punct	(,complicated
R2520	T3420	T3421	aux	to,reverse
R2521	T3421	T3419	xcomp	reverse,utilized
R2522	T3422	T3423	compound	TMZ,resistance
R2523	T3470	T3472	nmod	Beier,al.
R2524	T3423	T3421	dobj	resistance,reverse
R2525	T3424	T3421	prep	in,reverse
R2526	T3425	T3424	pobj	GBMs,in
R2527	T3471	T3472	nmod	et,al.
R2528	T3472	T3465	punct	al.,complicated
R2529	T3426	T3429	punct	(,al.
R2530	T3473	T3472	punct	",",al.
R2531	T3427	T3429	nmod	Sun,al.
R2532	T3428	T3429	nmod	et,al.
R2533	T3429	T3419	parataxis	al.,utilized
R2534	T3474	T3472	npadvmod	2011,al.
R2535	T3430	T3429	punct	",",al.
R2536	T3431	T3429	npadvmod	2012,al.
R2537	T3475	T3478	punct	;,al.
R2538	T3432	T3429	punct	),al.
R2539	T3433	T3419	punct	.,utilized
R2540	T3434	T3436	compound	Cancer,cells
R2541	T3476	T3478	compound	Chen,al.
R2542	T3435	T3436	compound	stem,cells
R2543	T3436	T3437	nsubj	cells,are
R2544	T3437	T3437	ROOT	are,are
R2545	T3477	T3478	compound	et,al.
R2546	T3478	T3478	ROOT	al.,al.
R2547	T3479	T3478	punct	",",al.
R2548	T3438	T3437	advmod	probably,are
R2549	T3439	T3440	det	the,key
R2550	T3480	T3478	npadvmod	2012,al.
R2551	T3440	T3437	attr	key,are
R2552	T3441	T3440	prep	to,key
R2553	T3481	T3478	punct	),al.
R2554	T3442	T3441	pobj	failure,to
R2555	T3482	T3478	punct	.,al.
R2556	T3483	T3486	amod	CD133-positive,cells
R2557	T3484	T3485	compound	cancer,stem
R2558	T3485	T3486	compound	stem,cells
R2559	T3488	T3488	ROOT	expressed,expressed
R2560	T3489	T3488	prep	in,expressed
R2561	T3490	T3493	det	both,cells
R2562	T3491	T3493	amod	normal,cells
R2563	T3486	T3488	nsubjpass	cells,expressed
R2564	T3492	T3493	compound	stem,cells
R2565	T3493	T3489	pobj	cells,in
R2566	T3494	T3493	cc	and,cells
R2567	T3495	T3496	compound	cancer,stem
R2568	T3487	T3488	auxpass	are,expressed
R2569	T3496	T3497	compound	stem,cells
R2570	T3497	T3493	conj	cells,cells
R2571	T3498	T3488	punct	(,expressed
R2572	T3499	T3488	dep	Donovan,expressed
R2573	T3500	T3499	cc	and,Donovan
R2574	T3501	T3499	conj	Pilkington,Donovan
R2575	T3502	T3501	punct	",",Pilkington
R2576	T3503	T3501	npadvmod	2012,Pilkington
R2577	T3504	T3501	punct	),Pilkington
R2578	T3505	T3488	punct	.,expressed
R2579	T3506	T3529	advmod	However,established
R2580	T3507	T3529	punct	",",established
R2581	T3508	T3509	det	the,role
R2582	T3509	T3529	nsubjpass	role,established
R2583	T3510	T3509	prep	of,role
R2584	T3511	T3510	pobj	CD133,of
R2585	T3512	T3509	prep	as,role
R2586	T3513	T3514	det	a,marker
R2587	T3514	T3512	pobj	marker,as
R2588	T3515	T3514	prep	for,marker
R2589	T3516	T3519	amod	glioma,cells
R2590	T3517	T3518	compound	cancer,stem
R2591	T3518	T3519	compound	stem,cells
R2592	T3519	T3515	pobj	cells,for
R2593	T3520	T3519	amod	relative,cells
R2594	T3521	T3520	prep	to,relative
R2595	T3522	T3524	poss	its,function
R2596	T3523	T3524	amod	biological,function
R2597	T3524	T3521	pobj	function,to
R2598	T3525	T3529	aux	has,established
R2599	T3526	T3529	advmod	yet,established
R2600	T3527	T3529	aux	to,established
R2601	T3528	T3529	auxpass	be,established
R2602	T3529	T3529	ROOT	established,established
R2603	T3530	T3529	punct	.,established

bionlp-st-ge-2016-test-ihmc

Id	Subject	Object	Predicate	Lexical cue
T2502	2879-2916	Negative_regulation	denotes	which blocks MGMT protein expression,
T2501	2832-2878	Positive_regulation	denotes	An increase in MGMT gene promoter methylation,
T2500	1867-1908	Regulation	denotes	MAPO2 gene encodes a novel 37-kDa protein
T2499	3314-3327	Positive_regulation	denotes	p53 signaling
T2498	1435-1483	Negative_regulation	denotes	inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
T2497	3713-3756	Binding	denotes	of mitochondrial respiratory chain coupling
T2496	2892-2916	Gene_expression	denotes	MGMT protein expression,
T2495	3757-3810	Negative_regulation	denotes	to suppress the production of reactive oxygen species
T2494	2965-2990	Positive_regulation	denotes	overexpressed microRNA-21
T2493	2965-2990	Gene_expression	denotes	overexpressed microRNA-21
T2492	3700-3810	Positive_regulation	denotes	Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species
T2491	5177-5205	Entity	denotes	other chemotherapeutic drugs
T2490	3716-3747	Entity	denotes	mitochondrial respiratory chain
T2489	4936-4939	Entity	denotes	TMZ
T2488	346-360	Entity	denotes	Friedman et al
T2487	2402-2406	Protein	denotes	Roos
T2486	3185-3194	Entity	denotes	Integrins
T2485	1867-1872	Protein	denotes	MAPO2
T2484	4183-4199	Entity	denotes	O6-methylguanine
T2483	4483-4495	Entity	denotes	resveratrol,
T2482	2892-2896	Protein	denotes	MGMT
T2481	1303-1330	Entity	denotes	The O6-methylguanine lesion
T2480	1638-1649	Entity	denotes	TMZ-induced
T2479	5303-5329	Entity	denotes	positive cancer stem cells
T2478	4440-4475	Entity	denotes	Interferon-β (IFN-β), levetiracetam
T2477	2772-2777	Entity	denotes	cells
T2476	1142-1154	Entity	denotes	Temozolomide
T2475	2036-2084	Protein	denotes	by O6-methylguanine-DNA methyltransferase (MGMT)
T2474	1886-1908	Protein	denotes	a novel 37-kDa protein
T2473	3968-3972	Protein	denotes	MGMT
T2472	4012-4023	Entity	denotes	lomeguatrib
T2471	4183-4207	Entity	denotes	O6-methylguanine adducts
T2470	4515-4518	Protein	denotes	VAP
T2469	4548-4551	Entity	denotes	TMZ
T2468	2006-2084	Entity	denotes	a substrate for direct repair by O6-methylguanine-DNA methyltransferase (MGMT)
T2467	3874-3877	Entity	denotes	TMZ
T2466	176-182	Entity	denotes	Silber
T2465	654-708	Entity	denotes	the monofunctional alkylating agent temozolomide (TMZ)
T2464	1469-1483	Protein	denotes	by a pan-Bcl-2
T2463	502-512	Entity	denotes	Haar et al
T2462	3616-3633	Entity	denotes	N7-methylguanine,
T2461	1975-2002	Entity	denotes	The O6-methylguanine lesion
T2460	3827-3865	Protein	denotes	by cytochrome c oxidase contributes in
T2459	5169-5172	Entity	denotes	TMZ
T2458	2750-2754	Protein	denotes	MGMT
T2457	5442-5450	Protein	denotes	of CD133
T2456	791-794	Entity	denotes	TMZ
T2455	4786-4789	Entity	denotes	TMZ
T2454	4758-4763	Protein	denotes	STAT3
T2453	2267-2275	Protein	denotes	proteins
T2452	2660-2663	Protein	denotes	MMR
T2451	1568-1574	Entity	denotes	of TMZ
T2450	1975-2002	Entity	denotes	The O6-methylguanine lesion
T2449	3098-3109	Protein	denotes	MicroRNA-21
T2448	2999-3008	Protein	denotes	Bax/Bcl-2
T2447	3968-3989	Entity	denotes	MGMT pseudosubstrates
T2446	2410-2412	Entity	denotes	al
T2445	1800-1831	Entity	denotes	O6-methylguanine lesion-induced
T2444	1240-1256	Entity	denotes	N7-methylguanine
T2443	2844-2878	Protein	denotes	in MGMT gene promoter methylation,
T2442	2194-2210	Entity	denotes	O6-methylguanine
T2441	4745-4754	Entity	denotes	inhibitor
T2440	4323-4326	Entity	denotes	NAD
T2439	2194-2210	Entity	denotes	O6-methylguanine
T2438	825-854	Entity	denotes	cancer stem cells, microRNAs,
T2437	2847-2851	Protein	denotes	MGMT
T2436	3934-3937	Entity	denotes	TMZ
T2435	2999-3008	Protein	denotes	Bax/Bcl-2
T2434	5093-5096	Entity	denotes	TMZ
T2433	2079-2083	Protein	denotes	MGMT
T2432	3573-3611	Entity	denotes	the cytotoxic lesions N3-methyladenine
T2431	2490-2493	Entity	denotes	TMZ
T2430	4500-4519	Entity	denotes	valproic acid (VAP)
T2429	887-994	Entity	denotes	tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many
T2428	1484-1497	Entity	denotes	inhibitor (−)
T2427	4625-4659	Entity	denotes	Resveratrol, a natural polyphenol,
T2426	2292-2352	Protein	denotes	protein kinase that ultimately leads to apoptotic cell death
T2425	4148-4151	Entity	denotes	TMZ
T2424	5021-5024	Protein	denotes	Sun
T2423	2441-2445	Protein	denotes	MGMT
T2422	4739-4773	Protein	denotes	STAT3 inhibitor or STAT3 knockdown
T2421	2687-2690	Entity	denotes	TMZ
T2420	1484-1506	Entity	denotes	inhibitor (−)-gossypol
T2419	1765-1773	Protein	denotes	C1orf201
T2418	4183-4199	Entity	denotes	O6-methylguanine
T2417	1758-1774	Protein	denotes	MAPO2 (C1orf201)
T2416	2529-2542	Entity	denotes	Pollack et al
T2415	4186-4199	Entity	denotes	methylguanine
T2414	3659-3662	Entity	denotes	TMZ
T2413	4997-5000	Entity	denotes	TMZ
T2412	868-871	Entity	denotes	DNA
T2411	1758-1779	Protein	denotes	MAPO2 (C1orf201) gene
T2410	3153-3165	Entity	denotes	cancer cells
T2409	2857-2865	Entity	denotes	promoter
T2408	5297-5302	Protein	denotes	CD133
T2407	2965-2990	Protein	denotes	overexpressed microRNA-21
T2406	2747-2768	Entity	denotes	of MGMT gene promoter
T2405	972-984	Protein	denotes	STAT3 kinase
T2404	4669-4672	Entity	denotes	TMZ
T2403	3079-3082	Protein	denotes	Shi
T2402	4355-4358	Entity	denotes	TMZ
T2401	1717-1750	Entity	denotes	GBM cells (Knizhnik et al., 2013)
T2400	673-689	Entity	denotes	alkylating agent
T2399	972-977	Protein	denotes	STAT3
T2398	4691-4706	Protein	denotes	NF-κB-dependent
T2397	3056-3067	Entity	denotes	TMZ-induced
T2396	4638-4658	Entity	denotes	a natural polyphenol
T2395	2747-2768	Protein	denotes	of MGMT gene promoter
T2394	4044-4050	Entity	denotes	to TMZ
T2393	5374-5391	Entity	denotes	cancer stem cells
T2392	1200-1216	Entity	denotes	O6-methylguanine
T2391	704-707	Entity	denotes	TMZ
T2390	3351-3362	Entity	denotes	glioma cell
T2389	1303-1330	Entity	denotes	The O6-methylguanine lesion
T2388	2892-2904	Protein	denotes	MGMT protein
T2387	5467-5491	Entity	denotes	glioma cancer stem cells
T2386	3314-3317	Protein	denotes	p53
T2385	2181-2185	Protein	denotes	MGMT
T2384	1240-1256	Entity	denotes	N7-methylguanine
T2383	5040-5057	Entity	denotes	Cancer stem cells
T2382	5130-5139	Entity	denotes	stem cell
T2381	1939-1948	Protein	denotes	this gene
T2380	5504-5527	Entity	denotes	its biological function
T2379	4074-4118	Entity	denotes	Methoxyamine-blocker of base excision repair
T2378	1200-1216	Entity	denotes	O6-methylguanine
T2377	1174-1189	Entity	denotes	of DNA lesions,
T2376	3991-4007	Entity	denotes	O6-benzylguanine
T2375	3003-3008	Protein	denotes	Bcl-2
T2374	4560-4574	Protein	denotes	MGMT-dependent
T2373	855-859	Entity	denotes	drug
T2372	3377-3406	Entity	denotes	TMZ (Janouskova et al., 2012)
T2371	3577-3586	Entity	denotes	cytotoxic
T2370	3019-3028	Protein	denotes	caspase-3
T2369	5352-5369	Entity	denotes	normal stem cells
T2368	3489-3520	Protein	denotes	The base excision repair enzyme
T2367	4440-4461	Protein	denotes	Interferon-β (IFN-β),
T2366	1446-1468	Protein	denotes	of antiapoptotic Bcl-2
T2365	3843-3850	Protein	denotes	oxidase
T2364	1800-1831	Entity	denotes	O6-methylguanine lesion-induced
T2363	3616-3633	Entity	denotes	N7-methylguanine,
T2362	3812-3815	Protein	denotes	ROS
T2361	4454-4459	Protein	denotes	IFN-β
T2360	1218-1234	Entity	denotes	N3-methyladenine
T2359	1867-1877	Protein	denotes	MAPO2 gene
R1554	T2359	T2500	causeOf	MAPO2 gene,MAPO2 gene encodes a novel 37-kDa protein
R1556	T2366	T2498	themeOf	of antiapoptotic Bcl-2,inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
R1562	T2386	T2499	causeOf	p53,p53 signaling
R1563	T2388	T2496	themeOf	MGMT protein,"MGMT protein expression,"
R1568	T2406	T2458	partOf	of MGMT gene promoter,MGMT
R1569	T2407	T2493	themeOf	overexpressed microRNA-21,overexpressed microRNA-21
R1570	T2407	T2494	themeOf	overexpressed microRNA-21,overexpressed microRNA-21
R1571	T2464	T2498	causeOf	by a pan-Bcl-2,inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
R1572	T2474	T2500	themeOf	a novel 37-kDa protein,MAPO2 gene encodes a novel 37-kDa protein
R1573	T2490	T2497	themeOf	mitochondrial respiratory chain,of mitochondrial respiratory chain coupling
R1574	T2496	T2502	themeOf	"MGMT protein expression,","which blocks MGMT protein expression,"
R1575	T2497	T2492	themeOf	of mitochondrial respiratory chain coupling,Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species

DLUT931

Id	Subject	Object	Predicate	Lexical cue
T2198	5303-5311	Gene_expression	denotes	positive
T2197	4745-4754	Negative_regulation	denotes	inhibitor
T2196	4764-4773	Negative_regulation	denotes	knockdown
T2195	3304-3313	Regulation	denotes	regulates
T2194	2965-2978	Positive_regulation	denotes	overexpressed
T2193	2885-2891	Negative_regulation	denotes	blocks
T2192	2905-2915	Gene_expression	denotes	expression
T2191	2835-2843	Positive_regulation	denotes	increase
T2190	2461-2472	Positive_regulation	denotes	contributes
T2189	2449-2453	Negative_regulation	denotes	loss
T2188	2427-2437	Gene_expression	denotes	expression
T2187	1780-1792	Positive_regulation	denotes	participates
T2186	1507-1512	Positive_regulation	denotes	leads
T2185	1484-1493	Negative_regulation	denotes	inhibitor
T2184	1435-1445	Negative_regulation	denotes	inhibition
T2183	5445-5450	Protein	denotes	CD133
T2182	5297-5302	Protein	denotes	CD133
T2181	4758-4763	Protein	denotes	STAT3
T2180	4739-4744	Protein	denotes	STAT3
T2179	4560-4564	Protein	denotes	MGMT
T2178	4454-4459	Protein	denotes	IFN-β
T2177	4440-4452	Protein	denotes	Interferon-β
T2176	3968-3972	Protein	denotes	MGMT
T2175	3314-3317	Protein	denotes	p53
T2174	3098-3109	Protein	denotes	MicroRNA-21
T2173	3019-3028	Protein	denotes	caspase-3
T2172	3003-3008	Protein	denotes	Bcl-2
T2171	2999-3002	Protein	denotes	Bax
T2170	2979-2990	Protein	denotes	microRNA-21
T2169	2892-2896	Protein	denotes	MGMT
T2168	2847-2851	Protein	denotes	MGMT
T2167	2750-2754	Protein	denotes	MGMT
T2166	2441-2445	Protein	denotes	MGMT
T2165	2181-2185	Protein	denotes	MGMT
T2164	2079-2083	Protein	denotes	MGMT
T2163	2039-2077	Protein	denotes	O6-methylguanine-DNA methyltransferase
T2162	1867-1872	Protein	denotes	MAPO2
T2161	1765-1773	Protein	denotes	C1orf201
T2160	1758-1763	Protein	denotes	MAPO2
T2159	1478-1483	Protein	denotes	Bcl-2
T2158	1463-1468	Protein	denotes	Bcl-2
R1475	T2158	T2184	themeOf	Bcl-2,inhibition
R1489	T2159	T2185	themeOf	Bcl-2,inhibitor
R1491	T2160	T2187	themeOf	MAPO2,participates
R1493	T2161	T2187	themeOf	C1orf201,participates
R1494	T2166	T2188	themeOf	MGMT,expression
R1495	T2168	T2191	themeOf	MGMT,increase
R1496	T2169	T2192	themeOf	MGMT,expression
R1497	T2170	T2194	themeOf	microRNA-21,overexpressed
R1498	T2175	T2195	themeOf	p53,regulates
R1499	T2180	T2197	themeOf	STAT3,inhibitor
R1500	T2181	T2196	themeOf	STAT3,knockdown
R1501	T2182	T2198	themeOf	CD133,positive
R1503	T2184	T2186	themeOf	inhibition,leads
R1504	T2188	T2189	themeOf	expression,loss
R1505	T2188	T2190	themeOf	expression,contributes
R1507	T2192	T2193	themeOf	expression,blocks
R1508	T2196	T2197	causeOf	knockdown,inhibitor

BioNLP16_Messiy

Id	Subject	Object	Predicate	Lexical cue
T2262	2427-2437	Gene_expression	denotes	expression
T2261	2461-2472	Positive_regulation	denotes	contributes
T2260	1435-1445	Negative_regulation	denotes	inhibition
T2259	5445-5450	Protein	denotes	CD133
T2258	5297-5302	Protein	denotes	CD133
T2257	4758-4763	Protein	denotes	STAT3
T2256	4739-4744	Protein	denotes	STAT3
T2255	4560-4564	Protein	denotes	MGMT
T2254	4454-4459	Protein	denotes	IFN-β
T2253	4440-4452	Protein	denotes	Interferon-β
T2252	3968-3972	Protein	denotes	MGMT
T2251	3314-3317	Protein	denotes	p53
T2250	3098-3109	Protein	denotes	MicroRNA-21
T2249	3019-3028	Protein	denotes	caspase-3
T2248	3003-3008	Protein	denotes	Bcl-2
T2247	2999-3002	Protein	denotes	Bax
T2246	2979-2990	Protein	denotes	microRNA-21
T2245	2892-2896	Protein	denotes	MGMT
T2244	2847-2851	Protein	denotes	MGMT
T2243	2750-2754	Protein	denotes	MGMT
T2242	2441-2445	Protein	denotes	MGMT
T2241	2181-2185	Protein	denotes	MGMT
T2240	2079-2083	Protein	denotes	MGMT
T2239	2039-2077	Protein	denotes	O6-methylguanine-DNA methyltransferase
T2238	1867-1872	Protein	denotes	MAPO2
T2237	1765-1773	Protein	denotes	C1orf201
T2236	1758-1763	Protein	denotes	MAPO2
T2235	1478-1483	Protein	denotes	Bcl-2
T2234	1463-1468	Protein	denotes	Bcl-2
T2270	5303-5311	Gene_expression	denotes	positive
T2269	4745-4754	Negative_regulation	denotes	inhibitor
T2268	4764-4773	Negative_regulation	denotes	knockdown
T2267	4520-4528	Positive_regulation	denotes	increase
T2266	2991-2998	Negative_regulation	denotes	reduces
T2265	2965-2978	Positive_regulation	denotes	overexpressed
T2264	2885-2891	Negative_regulation	denotes	blocks
T2263	2905-2915	Gene_expression	denotes	expression
R1520	T2234	T2260	themeOf	Bcl-2,inhibition
R1522	T2242	T2262	themeOf	MGMT,expression
R1524	T2245	T2263	themeOf	MGMT,expression
R1525	T2246	T2265	themeOf	microRNA-21,overexpressed
R1527	T2249	T2266	themeOf	caspase-3,reduces
R1528	T2253	T2267	themeOf	Interferon-β,increase
R1531	T2256	T2269	themeOf	STAT3,inhibitor
R1535	T2256	T2268	themeOf	STAT3,knockdown
R1536	T2257	T2268	themeOf	STAT3,knockdown
R1539	T2258	T2270	themeOf	CD133,positive
R1542	T2262	T2261	themeOf	expression,contributes
R1543	T2263	T2264	themeOf	expression,blocks

BioNLP16_DUT

Id	Subject	Object	Predicate	Lexical cue
T2138	5334-5343	Gene_expression	denotes	expressed
T2137	5303-5311	Gene_expression	denotes	positive
T2136	4745-4754	Negative_regulation	denotes	inhibitor
T2135	4764-4773	Negative_regulation	denotes	knockdown
T2134	4520-4528	Positive_regulation	denotes	increase
T2133	2965-2978	Positive_regulation	denotes	overexpressed
T2132	2965-2978	Gene_expression	denotes	overexpressed
T2131	2991-2998	Negative_regulation	denotes	reduces
T2130	2885-2891	Negative_regulation	denotes	blocks
T2129	2905-2915	Gene_expression	denotes	expression
T2128	2461-2472	Positive_regulation	denotes	contributes
T2127	2427-2437	Gene_expression	denotes	expression
T2126	1435-1445	Negative_regulation	denotes	inhibition
T2125	5445-5450	Protein	denotes	CD133
T2124	5297-5302	Protein	denotes	CD133
T2123	4758-4763	Protein	denotes	STAT3
T2122	4739-4744	Protein	denotes	STAT3
T2121	4560-4564	Protein	denotes	MGMT
T2120	4454-4459	Protein	denotes	IFN-β
T2119	4440-4452	Protein	denotes	Interferon-β
T2118	3968-3972	Protein	denotes	MGMT
T2117	3314-3317	Protein	denotes	p53
T2116	3098-3109	Protein	denotes	MicroRNA-21
T2115	3019-3028	Protein	denotes	caspase-3
T2114	3003-3008	Protein	denotes	Bcl-2
T2113	2999-3002	Protein	denotes	Bax
T2112	2979-2990	Protein	denotes	microRNA-21
T2111	2892-2896	Protein	denotes	MGMT
T2110	2847-2851	Protein	denotes	MGMT
T2109	2750-2754	Protein	denotes	MGMT
T2108	2441-2445	Protein	denotes	MGMT
T2107	2181-2185	Protein	denotes	MGMT
T2106	2079-2083	Protein	denotes	MGMT
T2105	2039-2077	Protein	denotes	O6-methylguanine-DNA methyltransferase
T2104	1867-1872	Protein	denotes	MAPO2
T2103	1765-1773	Protein	denotes	C1orf201
T2102	1758-1763	Protein	denotes	MAPO2
T2101	1478-1483	Protein	denotes	Bcl-2
T2100	1463-1468	Protein	denotes	Bcl-2
R1476	T2100	T2126	themeOf	Bcl-2,inhibition
R1477	T2108	T2127	themeOf	MGMT,expression
R1478	T2111	T2129	themeOf	MGMT,expression
R1479	T2112	T2132	themeOf	microRNA-21,overexpressed
R1480	T2112	T2131	causeOf	microRNA-21,reduces
R1481	T2115	T2131	themeOf	caspase-3,reduces
R1482	T2119	T2134	themeOf	Interferon-β,increase
R1483	T2122	T2136	themeOf	STAT3,inhibitor
R1484	T2122	T2135	themeOf	STAT3,knockdown
R1485	T2123	T2135	themeOf	STAT3,knockdown
R1486	T2124	T2137	themeOf	CD133,positive
R1487	T2124	T2138	themeOf	CD133,expressed
R1488	T2127	T2128	themeOf	expression,contributes
R1490	T2129	T2130	themeOf	expression,blocks
R1492	T2132	T2133	themeOf	overexpressed,overexpressed

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T2157	3314-3317	http://www.uniprot.org/uniprot/P04637	denotes	p53
T2156	3019-3028	http://www.uniprot.org/uniprot/P42574	denotes	caspase-3
T2155	4560-4564	http://www.uniprot.org/uniprot/P16455	denotes	MGMT
T2154	3968-3972	http://www.uniprot.org/uniprot/P16455	denotes	MGMT
T2153	2892-2896	http://www.uniprot.org/uniprot/P16455	denotes	MGMT
T2152	2847-2851	http://www.uniprot.org/uniprot/P16455	denotes	MGMT
T2151	2750-2754	http://www.uniprot.org/uniprot/P16455	denotes	MGMT
T2150	2441-2445	http://www.uniprot.org/uniprot/P16455	denotes	MGMT
T2149	2181-2185	http://www.uniprot.org/uniprot/P16455	denotes	MGMT
T2148	2079-2083	http://www.uniprot.org/uniprot/P16455	denotes	MGMT
T2147	2056-2077	http://www.uniprot.org/uniprot/Q9UBC3	denotes	DNA methyltransferase
T2146	2056-2077	http://www.uniprot.org/uniprot/Q9UIS9	denotes	DNA methyltransferase
T2145	2056-2077	http://www.uniprot.org/uniprot/Q9UBB5	denotes	DNA methyltransferase
T2144	2056-2077	http://www.uniprot.org/uniprot/O95243	denotes	DNA methyltransferase
T2143	2056-2077	http://www.uniprot.org/uniprot/Q9Y6K1	denotes	DNA methyltransferase
T2142	2056-2077	http://www.uniprot.org/uniprot/P26358	denotes	DNA methyltransferase
T2141	4758-4763	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T2140	4739-4744	http://www.uniprot.org/uniprot/P40763	denotes	STAT3
T2139	972-977	http://www.uniprot.org/uniprot/P40763	denotes	STAT3

bionlp-st-ge-2016-test-proteins

Id	Subject	Object	Predicate	Lexical cue
T1966	5445-5450	Protein	denotes	CD133
T1965	5297-5302	Protein	denotes	CD133
T1964	4758-4763	Protein	denotes	STAT3
T1963	4739-4744	Protein	denotes	STAT3
T1962	4560-4564	Protein	denotes	MGMT
T1961	4454-4459	Protein	denotes	IFN-β
T1960	4440-4452	Protein	denotes	Interferon-β
T1959	3968-3972	Protein	denotes	MGMT
T1958	3314-3317	Protein	denotes	p53
T1957	3098-3109	Protein	denotes	MicroRNA-21
T1956	3019-3028	Protein	denotes	caspase-3
T1955	3003-3008	Protein	denotes	Bcl-2
T1954	2999-3002	Protein	denotes	Bax
T1953	2979-2990	Protein	denotes	microRNA-21
T1952	2892-2896	Protein	denotes	MGMT
T1951	2847-2851	Protein	denotes	MGMT
T1950	2750-2754	Protein	denotes	MGMT
T1949	2441-2445	Protein	denotes	MGMT
T1948	2181-2185	Protein	denotes	MGMT
T1947	2079-2083	Protein	denotes	MGMT
T1946	2039-2077	Protein	denotes	O6-methylguanine-DNA methyltransferase
T1945	1867-1872	Protein	denotes	MAPO2
T1944	1765-1773	Protein	denotes	C1orf201
T1943	1758-1763	Protein	denotes	MAPO2
T1942	1478-1483	Protein	denotes	Bcl-2
T1941	1463-1468	Protein	denotes	Bcl-2

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T1940	2866-2877	Antecedent	denotes	methylation
T1939	2879-2884	Anaphor	denotes	which
R1455	T1939	T1940	boundBy	which,methylation

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T1086	995-1001	NN	denotes	others
T1896	5542-5553	VB	denotes	established
T1895	5539-5541	VB	denotes	be
T1894	5536-5538	TO	denotes	to
T1893	5532-5535	RB	denotes	yet
T1892	5528-5531	VB	denotes	has
T1891	5519-5527	NN	denotes	function
T1890	5508-5518	JJ	denotes	biological
T1889	5504-5507	PRP-DOLLAR-	denotes	its
T1888	5501-5503	TO	denotes	to
T1887	5492-5500	JJ	denotes	relative
T1886	5486-5491	NN	denotes	cells
T1885	5481-5485	NN	denotes	stem
T1884	5474-5480	NN	denotes	cancer
T1883	5467-5473	NN	denotes	glioma
T1882	5463-5466	IN	denotes	for
T1881	5456-5462	NN	denotes	marker
T1880	5454-5455	DT	denotes	a
T1879	5451-5453	IN	denotes	as
T1878	5445-5450	NN	denotes	CD133
T1877	5442-5444	IN	denotes	of
T1876	5437-5441	NN	denotes	role
T1875	5433-5436	DT	denotes	the
T1874	5431-5432	-COMMA-	denotes	,
T1873	5424-5431	RB	denotes	However
T1872	5421-5422	-RRB-	denotes	)
T1871	5417-5421	CD	denotes	2012
T1870	5415-5416	-COMMA-	denotes	,
T1869	5405-5415	NNP	denotes	Pilkington
T1868	5401-5404	CC	denotes	and
T1867	5393-5400	NNP	denotes	Donovan
T1866	5392-5393	-LRB-	denotes	(
T1865	5386-5391	NN	denotes	cells
T1864	5381-5385	NN	denotes	stem
T1863	5374-5380	NN	denotes	cancer
T1862	5370-5373	CC	denotes	and
T1861	5364-5369	NN	denotes	cells
T1860	5359-5363	NN	denotes	stem
T1859	5352-5358	JJ	denotes	normal
T1858	5347-5351	CC	denotes	both
T1857	5344-5346	IN	denotes	in
T1856	5334-5343	VB	denotes	expressed
T1855	5330-5333	VB	denotes	are
T1854	5324-5329	NN	denotes	cells
T1853	5319-5323	NN	denotes	stem
T1852	5312-5318	NN	denotes	cancer
T1851	5297-5311	JJ	denotes	CD133-positive
T1850	5294-5295	-RRB-	denotes	)
T1849	5290-5294	CD	denotes	2012
T1848	5288-5289	-COMMA-	denotes	,
T1847	5285-5288	FW	denotes	al.
T1846	5282-5284	FW	denotes	et
T1845	5277-5281	NNP	denotes	Chen
T1844	5275-5276	-COLON-	denotes	;
T1843	5271-5275	CD	denotes	2011
T1842	5269-5270	-COMMA-	denotes	,
T1841	5266-5269	FW	denotes	al.
T1840	5263-5265	FW	denotes	et
T1839	5257-5262	NNP	denotes	Beier
T1838	5256-5257	-LRB-	denotes	(
T1837	5248-5255	VB	denotes	thought
T1836	5237-5247	RB	denotes	previously
T1835	5232-5236	IN	denotes	than
T1834	5220-5231	VB	denotes	complicated
T1833	5215-5219	RB	denotes	more
T1832	5210-5214	VB	denotes	been
T1831	5206-5209	VB	denotes	has
T1830	5200-5205	NN	denotes	drugs
T1829	5183-5199	JJ	denotes	chemotherapeutic
T1828	5177-5182	JJ	denotes	other
T1827	5173-5176	CC	denotes	and
T1826	5169-5172	NN	denotes	TMZ
T1825	5164-5168	IN	denotes	with
T1824	5154-5163	NN	denotes	treatment
T1823	5149-5153	IN	denotes	from
T1822	5140-5148	NN	denotes	survival
T1821	5135-5139	NN	denotes	cell
T1820	5130-5134	NN	denotes	stem
T1819	5123-5129	NN	denotes	cancer
T1818	5120-5122	IN	denotes	of
T1817	5112-5119	NN	denotes	concept
T1816	5108-5111	DT	denotes	The
T1815	5097-5106	NN	denotes	treatment
T1814	5093-5096	NN	denotes	TMZ
T1813	5090-5092	IN	denotes	in
T1812	5082-5089	NN	denotes	failure
T1811	5079-5081	TO	denotes	to
T1810	5075-5078	NN	denotes	key
T1809	5071-5074	DT	denotes	the
T1808	5062-5070	RB	denotes	probably
T1807	5058-5061	VB	denotes	are
T1806	5052-5057	NN	denotes	cells
T1805	5047-5051	NN	denotes	stem
T1804	5040-5046	NN	denotes	Cancer
T1803	5037-5038	-RRB-	denotes	)
T1802	5033-5037	CD	denotes	2012
T1801	5031-5032	-COMMA-	denotes	,
T1800	5028-5031	FW	denotes	al.
T1799	5025-5027	FW	denotes	et
T1798	5021-5024	NNP	denotes	Sun
T1797	5020-5021	-LRB-	denotes	(
T1796	5015-5019	NN	denotes	GBMs
T1795	5012-5014	IN	denotes	in
T1794	5001-5011	NN	denotes	resistance
T1793	4997-5000	NN	denotes	TMZ
T1792	4989-4996	VB	denotes	reverse
T1791	4986-4988	TO	denotes	to
T1790	4977-4985	VB	denotes	utilized
T1789	4974-4976	VB	denotes	be
T1788	4970-4973	MD	denotes	can
T1787	4960-4969	NN	denotes	hyperoxia
T1786	4952-4959	VB	denotes	Induced
T1785	4940-4950	NN	denotes	resistance
T1784	4936-4939	NN	denotes	TMZ
T1783	4933-4935	IN	denotes	of
T1782	4921-4932	NN	denotes	development
T1781	4917-4920	DT	denotes	the
T1780	4912-4916	IN	denotes	with
T1779	4901-4911	VB	denotes	associated
T1778	4898-4900	VB	denotes	be
T1777	4894-4897	MD	denotes	may
T1776	4890-4893	CC	denotes	and
T1775	4885-4889	NN	denotes	GBMs
T1774	4882-4884	IN	denotes	in
T1773	4875-4881	JJ	denotes	common
T1772	4872-4874	VB	denotes	is
T1771	4864-4871	NN	denotes	hypoxia
T1770	4851-4863	JJ	denotes	Intratumoral
T1769	4848-4849	-RRB-	denotes	)
T1768	4844-4848	CD	denotes	2012
T1767	4842-4843	-COMMA-	denotes	,
T1766	4839-4842	FW	denotes	al.
T1765	4836-4838	FW	denotes	et
T1764	4828-4835	NNP	denotes	Kohsaka
T1763	4827-4828	-LRB-	denotes	(
T1762	4821-4826	NN	denotes	lines
T1761	4816-4820	NN	denotes	cell
T1760	4812-4815	NN	denotes	GBM
T1759	4802-4811	JJ	denotes	resistant
T1758	4799-4801	IN	denotes	in
T1757	4790-4798	NN	denotes	efficacy
T1756	4786-4789	NN	denotes	TMZ
T1755	4774-4785	VB	denotes	potentiates
T1754	4764-4773	NN	denotes	knockdown
T1753	4758-4763	NN	denotes	STAT3
T1752	4755-4757	CC	denotes	or
T1751	4745-4754	NN	denotes	inhibitor
T1750	4739-4744	NN	denotes	STAT3
T1749	4736-4737	-RRB-	denotes	)
T1748	4732-4736	CD	denotes	2012
T1747	4730-4731	-COMMA-	denotes	,
T1746	4727-4730	FW	denotes	al.
T1745	4724-4726	FW	denotes	et
T1744	4718-4723	NNP	denotes	Huang
T1743	4717-4718	-LRB-	denotes	(
T1742	4707-4716	NN	denotes	mechanism
T1741	4691-4706	JJ	denotes	NF-κB-dependent
T1740	4688-4690	DT	denotes	an
T1739	4684-4687	IN	denotes	via
T1738	4673-4683	NN	denotes	resistance
T1737	4669-4672	NN	denotes	TMZ
T1736	4660-4668	VB	denotes	reverses
T1735	4658-4659	-COMMA-	denotes	,
T1734	4648-4658	NN	denotes	polyphenol
T1733	4640-4647	JJ	denotes	natural
T1732	4638-4639	DT	denotes	a
T1731	4636-4637	-COMMA-	denotes	,
T1730	4625-4636	NN	denotes	Resveratrol
T1729	4622-4623	-RRB-	denotes	)
T1728	4618-4622	CD	denotes	2012
T1727	4616-4617	-COMMA-	denotes	,
T1726	4613-4616	FW	denotes	al.
T1725	4610-4612	FW	denotes	et
T1724	4603-4609	NNP	denotes	Nakada
T1723	4602-4603	-LRB-	denotes	(
T1722	4591-4601	NN	denotes	mechanisms
T1721	4578-4590	JJ	denotes	-independent
T1720	4575-4577	CC	denotes	or
T1719	4560-4574	JJ	denotes	MGMT-dependent
T1718	4552-4559	IN	denotes	through
T1717	4548-4551	NN	denotes	TMZ
T1716	4545-4547	IN	denotes	of
T1715	4533-4544	NN	denotes	sensitivity
T1714	4529-4532	DT	denotes	the
T1713	4520-4528	VB	denotes	increase
T1712	4518-4519	-RRB-	denotes	)
T1711	4515-4518	NN	denotes	VAP
T1710	4514-4515	-LRB-	denotes	(
T1709	4509-4513	NN	denotes	acid
T1708	4500-4508	JJ	denotes	valproic
T1707	4496-4499	CC	denotes	and
T1706	4494-4495	-COMMA-	denotes	,
T1705	4483-4494	NN	denotes	resveratrol
T1704	4481-4482	-COMMA-	denotes	,
T1703	4480-4481	-RRB-	denotes	)
T1702	4477-4480	NN	denotes	LEV
T1701	4476-4477	-LRB-	denotes	(
T1700	4462-4475	NN	denotes	levetiracetam
T1699	4460-4461	-COMMA-	denotes	,
T1698	4459-4460	-RRB-	denotes	)
T1554	3595-3611	NN	denotes	N3-methyladenine
T1553	3587-3594	NN	denotes	lesions
T1552	3577-3586	JJ	denotes	cytotoxic
T1551	3573-3576	DT	denotes	the
T1550	3565-3572	VB	denotes	repairs
T1549	3559-3564	WDT	denotes	which
T1548	3557-3558	-COMMA-	denotes	,
T1547	3556-3557	-RRB-	denotes	)
T1546	3552-3556	NN	denotes	APNG
T1545	3551-3552	-LRB-	denotes	(
T1544	3521-3550	NN	denotes	alkylpurine-DNA-N-glycosylase
T1543	3514-3520	NN	denotes	enzyme
T1542	3507-3513	NN	denotes	repair
T1541	3498-3506	NN	denotes	excision
T1540	3493-3497	NN	denotes	base
T1539	3489-3492	DT	denotes	The
T1538	3469-3475	NN	denotes	grade
T1537	3464-3469	NN	denotes	high-
T1536	3453-3463	JJ	denotes	target for
T1535	3450-3453	IN	denotes	ic
T1534	3444-3450	NN	denotes	rapeut
T1533	3433-3444	JJ	denotes	ed as a the
T1532	3432-3433	DT	denotes	r
T1531	3430-3432	IN	denotes	de
T1530	3420-3430	VB	denotes	n is consi
T1529	3418-3420	VB	denotes	ri
T1528	3410-3418	NN	denotes	β1 integ
T1527	3406-3410	CD	denotes	. α5
T1526	3405-3406	-RRB-	denotes	)
T1525	3401-3405	CD	denotes	2012
T1524	3399-3400	-COMMA-	denotes	,
T1523	3396-3399	FW	denotes	al.
T1522	3393-3395	FW	denotes	et
T1521	3382-3392	NNP	denotes	Janouskova
T1520	3381-3382	-LRB-	denotes	(
T1519	3377-3380	NN	denotes	TMZ
T1518	3374-3376	TO	denotes	to
T1517	3363-3373	NN	denotes	resistance
T1516	3358-3362	NN	denotes	cell
T1515	3351-3357	NN	denotes	glioma
T1514	3343-3350	VB	denotes	induces
T1513	3337-3342	NN	denotes	event
T1512	3333-3336	DT	denotes	the
T1511	3329-3332	CC	denotes	and
T1510	3327-3328	-COMMA-	denotes	,
T1509	3318-3327	NN	denotes	signaling
T1508	3314-3317	NN	denotes	p53
T1507	3304-3313	VB	denotes	regulates
T1506	3293-3303	RB	denotes	negatively
T1505	3284-3292	NN	denotes	integrin
T1504	3279-3283	NN	denotes	α5β1
T1503	3265-3278	NN	denotes	chemotherapy.
T1502	3261-3264	CC	denotes	and
T1501	3248-3260	NN	denotes	radiotherapy
T1500	3245-3247	TO	denotes	to
T1499	3237-3244	NN	denotes	cancers
T1498	3228-3236	JJ	denotes	advanced
T1497	3225-3227	IN	denotes	of
T1496	3214-3224	NN	denotes	resistance
T1495	3210-3213	DT	denotes	the
T1494	3207-3209	IN	denotes	in
T1493	3202-3206	NN	denotes	role
T1492	3200-3201	DT	denotes	a
T1491	3195-3199	VB	denotes	play
T1490	3185-3194	NN	denotes	Integrins
T1489	3182-3183	-RRB-	denotes	)
T1488	3178-3182	CD	denotes	2012
T1487	3176-3177	-COMMA-	denotes	,
T1486	3173-3176	FW	denotes	al.
T1485	3170-3172	FW	denotes	et
T1484	3167-3169	NNP	denotes	Li
T1483	3166-3167	-LRB-	denotes	(
T1482	3160-3165	NN	denotes	cells
T1481	3153-3159	NN	denotes	cancer
T1480	3149-3152	IN	denotes	for
T1479	3142-3148	NN	denotes	factor
T1478	3129-3141	JJ	denotes	pro-survival
T1477	3127-3128	DT	denotes	a
T1476	3124-3126	IN	denotes	as
T1475	3113-3123	VB	denotes	considered
T1474	3110-3112	VB	denotes	is
T1473	3098-3109	NN	denotes	MicroRNA-21
T1472	3095-3096	-RRB-	denotes	)
T1471	3091-3095	CD	denotes	2010
T1470	3089-3090	-COMMA-	denotes	,
T1469	3086-3089	FW	denotes	al.
T1468	3083-3085	FW	denotes	et
T1467	3079-3082	NNP	denotes	Shi
T1466	3078-3079	-LRB-	denotes	(
T1465	3068-3077	NN	denotes	apoptosis
T1464	3056-3067	JJ	denotes	TMZ-induced
T1463	3047-3055	VB	denotes	blocking
T1462	3039-3046	RB	denotes	thereby
T1461	3037-3038	-COMMA-	denotes	,
T1460	3029-3037	NN	denotes	activity
T1459	3019-3028	NN	denotes	caspase-3
T1458	3015-3018	CC	denotes	and
T1457	3009-3014	NN	denotes	ratio
T1456	2999-3008	NN	denotes	Bax/Bcl-2
T1455	2991-2998	VB	denotes	reduces
T1454	2979-2990	NN	denotes	microRNA-21
T1453	2965-2978	VB	denotes	overexpressed
T1452	2963-2964	-COMMA-	denotes	,
T1451	2951-2963	RB	denotes	Intriguingly
T1450	2941-2949	NN	denotes	survival
T1449	2933-2940	NN	denotes	patient
T1448	2926-2932	NN	denotes	cancer
T1447	2917-2925	VB	denotes	prolongs
T1446	2915-2916	-COMMA-	denotes	,
T1445	2905-2915	NN	denotes	expression
T1444	2897-2904	NN	denotes	protein
T1443	2892-2896	NN	denotes	MGMT
T1442	2885-2891	VB	denotes	blocks
T1441	2879-2884	WDT	denotes	which
T1440	2877-2878	-COMMA-	denotes	,
T1439	2866-2877	NN	denotes	methylation
T1438	2857-2865	NN	denotes	promoter
T1437	2852-2856	NN	denotes	gene
T1436	2847-2851	NN	denotes	MGMT
T1435	2844-2846	IN	denotes	in
T1434	2835-2843	NN	denotes	increase
T1433	2832-2834	DT	denotes	An
T1432	2829-2830	-RRB-	denotes	)
T1431	2825-2829	CD	denotes	2012
T1430	2823-2824	-COMMA-	denotes	,
T1429	2820-2823	FW	denotes	al.
T1428	2817-2819	FW	denotes	et
T1427	2808-2816	FW	denotes	Villalva
T1426	2807-2808	-LRB-	denotes	(
T1425	2791-2806	NN	denotes	differentiation
T1424	2788-2790	TO	denotes	to
T1423	2778-2787	VB	denotes	committed
T1422	2772-2777	NN	denotes	cells
T1421	2769-2771	IN	denotes	in
T1420	2760-2768	NN	denotes	promoter
T1419	2755-2759	NN	denotes	gene
T1418	2750-2754	NN	denotes	MGMT
T1417	2747-2749	IN	denotes	of
T1416	2740-2746	NN	denotes	status
T1415	2728-2739	NN	denotes	methylation
T1414	2724-2727	DT	denotes	the
T1413	2719-2723	IN	denotes	with
T1412	2708-2718	VB	denotes	associated
T1411	2694-2707	RB	denotes	significantly
T1410	2691-2693	VB	denotes	is
T1409	2687-2690	NN	denotes	TMZ
T1408	2684-2686	TO	denotes	to
T1407	2672-2683	NN	denotes	Sensitivity
T1406	2664-2670	NN	denotes	system
T1405	2660-2663	NN	denotes	MMR
T1404	2656-2659	DT	denotes	the
T1403	2653-2655	IN	denotes	of
T1402	2645-2652	NN	denotes	absence
T1401	2641-2644	DT	denotes	the
T1400	2638-2640	IN	denotes	in
T1399	2632-2637	VB	denotes	fails
T1398	2622-2631	NN	denotes	signaling
T1397	2612-2621	JJ	denotes	apoptotic
T1396	2609-2611	IN	denotes	of
T1395	2598-2608	NN	denotes	initiation
T1394	2594-2597	DT	denotes	The
T1393	2591-2592	-RRB-	denotes	)
T1392	2587-2591	CD	denotes	2008
T1391	2585-2586	-COMMA-	denotes	,
T1390	2582-2585	FW	denotes	al.
T1389	2579-2581	FW	denotes	et
T1388	2570-2578	NNP	denotes	Sarkaria
T1387	2568-2569	-COLON-	denotes	;
T1386	2564-2568	CD	denotes	2008
T1385	2562-2563	-COMMA-	denotes	,
T1384	2559-2562	FW	denotes	al.
T1383	2556-2558	FW	denotes	et
T1382	2551-2555	NNP	denotes	Hegi
T1381	2549-2550	-COLON-	denotes	;
T1380	2545-2549	CD	denotes	2006
T1379	2543-2544	-COMMA-	denotes	,
T1378	2540-2543	FW	denotes	al.
T1377	2537-2539	FW	denotes	et
T1376	2529-2536	NNP	denotes	Pollack
T1375	2528-2529	-LRB-	denotes	(
T1374	2522-2527	NN	denotes	cases
T1373	2513-2521	JJ	denotes	clinical
T1372	2508-2512	JJ	denotes	many
T1371	2505-2507	IN	denotes	in
T1370	2494-2504	NN	denotes	resistance
T1369	2490-2493	NN	denotes	TMZ
T1368	2487-2489	TO	denotes	to
T1367	2473-2486	RB	denotes	significantly
T1366	2461-2472	VB	denotes	contributes
T1365	2457-2460	NN	denotes	MMR
T1364	2454-2456	IN	denotes	of
T1363	2449-2453	NN	denotes	loss
T1362	2446-2448	CC	denotes	or
T1361	2441-2445	NN	denotes	MGMT
T1360	2438-2440	IN	denotes	of
T1359	2427-2437	NN	denotes	expression
T1358	2422-2426	JJ	denotes	High
T1357	2419-2420	-RRB-	denotes	)
T1356	2415-2419	CD	denotes	2007
T1355	2413-2414	-COMMA-	denotes	,
T1354	2410-2413	FW	denotes	al.
T1353	2407-2409	FW	denotes	et
T1352	2402-2406	NNP	denotes	Roos
T1351	2400-2401	-COLON-	denotes	;
T1350	2396-2400	CD	denotes	2006
T1349	2394-2395	-COMMA-	denotes	,
T1348	2386-2394	NNP	denotes	Edelmann
T1347	2382-2385	CC	denotes	and
T1346	2377-2381	NNP	denotes	Wang
T1345	2375-2376	-COLON-	denotes	;
T1344	2371-2375	CD	denotes	2004
T1343	2369-2370	-COMMA-	denotes	,
T1342	2366-2369	FW	denotes	al.
T1341	2363-2365	FW	denotes	et
T1340	2354-2362	NNP	denotes	Caporali
T1339	2353-2354	-LRB-	denotes	(
T1320	2221-2231	NN	denotes	activation
T1319	2211-2220	VB	denotes	initiates
T1318	2194-2210	NN	denotes	O6-methylguanine
T1317	2192-2193	-COMMA-	denotes	,
T1316	2186-2192	NN	denotes	repair
T1315	2181-2185	NN	denotes	MGMT
T1314	2173-2180	IN	denotes	Without
T1313	2170-2171	-RRB-	denotes	)
T1312	2165-2170	NN	denotes	2012b
T1311	2163-2164	-COMMA-	denotes	,
T1310	2160-2163	FW	denotes	al.
T1309	2157-2159	FW	denotes	et
T1308	2151-2156	NNP	denotes	Zhang
T1307	2149-2150	-COLON-	denotes	;
T1306	2145-2149	CD	denotes	2009
T1305	2143-2144	-COMMA-	denotes	,
T1304	2140-2143	FW	denotes	al.
T1303	2137-2139	FW	denotes	et
T1302	2127-2136	NNP	denotes	Fukushima
T1301	2125-2126	-COLON-	denotes	;
T1300	2121-2125	CD	denotes	2008
T1299	2119-2120	-COMMA-	denotes	,
T1298	2116-2119	FW	denotes	al.
T1297	2113-2115	FW	denotes	et
T1296	2108-2112	NNP	denotes	Hegi
T1295	2106-2107	-COLON-	denotes	;
T1294	2102-2106	CD	denotes	2006
T1293	2100-2101	-COMMA-	denotes	,
T1292	2097-2100	FW	denotes	al.
T1291	2094-2096	FW	denotes	et
T1290	2086-2093	NNP	denotes	Pollack
T1289	2085-2086	-LRB-	denotes	(
T1288	2083-2084	-RRB-	denotes	)
T1287	2079-2083	NN	denotes	MGMT
T1286	2078-2079	-LRB-	denotes	(
T1285	2060-2077	NN	denotes	methyltransferase
T1284	2039-2059	NN	denotes	O6-methylguanine-DNA
T1283	2036-2038	IN	denotes	by
T1282	2029-2035	NN	denotes	repair
T1281	2022-2028	JJ	denotes	direct
T1280	2018-2021	IN	denotes	for
T1279	2008-2017	NN	denotes	substrate
T1278	2006-2007	DT	denotes	a
T1277	2003-2005	VB	denotes	is
T1276	1996-2002	NN	denotes	lesion
T1275	1979-1995	NN	denotes	O6-methylguanine
T1274	1975-1978	DT	denotes	The
T1273	1964-1973	NN	denotes	autophagy
T1272	1961-1963	IN	denotes	in
T1271	1952-1960	VB	denotes	involved
T1270	1949-1951	VB	denotes	is
T1269	1944-1948	NN	denotes	gene
T1268	1939-1943	DT	denotes	this
T1267	1931-1938	IN	denotes	whether
T1697	4454-4459	NN	denotes	IFN-β
T1696	4453-4454	-LRB-	denotes	(
T1695	4440-4452	NN	denotes	Interferon-β
T1694	4437-4438	-RRB-	denotes	)
T1693	4433-4437	CD	denotes	2011
T1692	4431-4432	-COMMA-	denotes	,
T1691	4428-4431	FW	denotes	al.
T1690	4425-4427	FW	denotes	et
T1689	4416-4424	NNP	denotes	Goellner
T1688	4415-4416	-LRB-	denotes	(
T1687	4411-4414	NN	denotes	GBM
T1686	4401-4410	JJ	denotes	recurrent
T1685	4397-4400	CC	denotes	and
T1684	4387-4396	JJ	denotes	resistant
T1683	4382-4386	IN	denotes	with
T1682	4373-4381	NN	denotes	patients
T1681	4370-4372	IN	denotes	in
T1680	4359-4369	NN	denotes	resistance
T1679	4355-4358	NN	denotes	TMZ
T1678	4347-4354	VB	denotes	reverse
T1677	4343-4346	MD	denotes	may
T1676	4330-4342	NN	denotes	biosynthesis
T1675	4328-4329	-RRB-	denotes	)
T1674	4327-4328	SYM	denotes	+
T1673	4326-4327	-LRB-	denotes	(
T1672	4323-4326	NN	denotes	NAD
T1671	4319-4322	CC	denotes	and
T1670	4312-4318	NN	denotes	repair
T1669	4303-4311	NN	denotes	excision
T1668	4298-4302	NN	denotes	base
T1667	4295-4297	IN	denotes	of
T1666	4285-4294	NN	denotes	targeting
T1665	4280-4284	JJ	denotes	Dual
T1664	4277-4278	-RRB-	denotes	)
T1663	4272-4277	NN	denotes	2012b
T1662	4270-4271	-COMMA-	denotes	,
T1661	4267-4270	FW	denotes	al.
T1660	4264-4266	FW	denotes	et
T1659	4258-4263	NNP	denotes	Zhang
T1658	4256-4257	-COLON-	denotes	;
T1657	4252-4256	CD	denotes	2011
T1656	4250-4251	-COMMA-	denotes	,
T1655	4247-4250	FW	denotes	al.
T1654	4244-4246	FW	denotes	et
T1653	4235-4243	NNP	denotes	Goellner
T1652	4234-4235	-LRB-	denotes	(
T1651	4224-4233	VB	denotes	tolerated
T1650	4221-4223	CC	denotes	or
T1649	4212-4220	VB	denotes	repaired
T1648	4208-4211	VB	denotes	are
T1647	4200-4207	NN	denotes	adducts
T1646	4183-4199	NN	denotes	O6-methylguanine
T1645	4178-4182	WRB	denotes	when
T1644	4165-4177	RB	denotes	particularly
T1643	4152-4164	NN	denotes	cytotoxicity
T1642	4148-4151	NN	denotes	TMZ
T1641	4145-4147	TO	denotes	to
T1640	4131-4144	RB	denotes	significantly
T1639	4119-4130	VB	denotes	contributes
T1638	4112-4118	NN	denotes	repair
T1637	4103-4111	NN	denotes	excision
T1636	4098-4102	NN	denotes	base
T1635	4095-4097	IN	denotes	of
T1634	4074-4094	NN	denotes	Methoxyamine-blocker
T1633	4071-4072	-RRB-	denotes	)
T1632	4066-4071	NN	denotes	2012b
T1631	4064-4065	-COMMA-	denotes	,
T1630	4061-4064	FW	denotes	al.
T1629	4058-4060	FW	denotes	et
T1628	4052-4057	NNP	denotes	Zhang
T1627	4051-4052	-LRB-	denotes	(
T1626	4047-4050	NN	denotes	TMZ
T1625	4044-4046	TO	denotes	to
T1624	4037-4043	NN	denotes	tumors
T1623	4027-4036	VB	denotes	sensitize
T1622	4024-4026	TO	denotes	to
T1621	4012-4023	NN	denotes	lomeguatrib
T1620	4008-4011	CC	denotes	and
T1619	3991-4007	NN	denotes	O6-benzylguanine
T1618	3989-3990	-COMMA-	denotes	,
T1617	3973-3989	NN	denotes	pseudosubstrates
T1616	3968-3972	NN	denotes	MGMT
T1615	3965-3967	IN	denotes	by
T1614	3956-3964	VB	denotes	achieved
T1613	3953-3955	VB	denotes	be
T1612	3949-3952	MD	denotes	may
T1611	3938-3948	NN	denotes	resistance
T1610	3934-3937	NN	denotes	TMZ
T1609	3931-3933	IN	denotes	of
T1608	3922-3930	NN	denotes	Reversal
T1607	3919-3920	-RRB-	denotes	)
T1606	3915-3919	CD	denotes	2011
T1605	3913-3914	-COMMA-	denotes	,
T1604	3910-3913	FW	denotes	al.
T1603	3907-3909	FW	denotes	et
T1602	3901-3906	NNP	denotes	Oliva
T1601	3900-3901	-LRB-	denotes	(
T1600	3892-3899	NN	denotes	gliomas
T1599	3889-3891	IN	denotes	in
T1598	3878-3888	NN	denotes	resistance
T1597	3874-3877	NN	denotes	TMZ
T1596	3871-3873	TO	denotes	to
T1595	3866-3870	NN	denotes	part
T1594	3863-3865	IN	denotes	in
T1593	3851-3862	VB	denotes	contributes
T1592	3843-3850	NN	denotes	oxidase
T1591	3841-3842	NN	denotes	c
T1590	3830-3840	NN	denotes	cytochrome
T1589	3827-3829	IN	denotes	by
T1588	3817-3826	VB	denotes	regulated
T1587	3815-3816	-RRB-	denotes	)
T1586	3812-3815	NN	denotes	ROS
T1585	3811-3812	-LRB-	denotes	(
T1584	3803-3810	NN	denotes	species
T1583	3796-3802	NN	denotes	oxygen
T1582	3787-3795	JJ	denotes	reactive
T1581	3784-3786	IN	denotes	of
T1580	3773-3783	NN	denotes	production
T1579	3769-3772	DT	denotes	the
T1578	3760-3768	VB	denotes	suppress
T1577	3757-3759	TO	denotes	to
T1576	3748-3756	NN	denotes	coupling
T1575	3742-3747	NN	denotes	chain
T1574	3730-3741	JJ	denotes	respiratory
T1573	3716-3729	JJ	denotes	mitochondrial
T1572	3713-3715	IN	denotes	of
T1571	3700-3712	NN	denotes	Upregulation
T1570	3697-3698	-RRB-	denotes	)
T1569	3693-3697	CD	denotes	2012
T1568	3691-3692	-COMMA-	denotes	,
T1567	3688-3691	FW	denotes	al.
T1566	3685-3687	FW	denotes	et
T1565	3675-3684	NNP	denotes	Agnihotri
T1564	3674-3675	-LRB-	denotes	(
T1563	3663-3673	NN	denotes	resistance
T1562	3659-3662	NN	denotes	TMZ
T1561	3655-3658	DT	denotes	the
T1560	3652-3654	IN	denotes	in
T1559	3639-3651	VB	denotes	participates
T1558	3634-3638	RB	denotes	also
T1557	3632-3633	-COMMA-	denotes	,
T1556	3616-3632	NN	denotes	N7-methylguanine
T1555	3612-3615	CC	denotes	and
T1266	1920-1930	VB	denotes	determined
T1265	1916-1919	RB	denotes	not
T1264	1913-1915	VB	denotes	is
T1263	1910-1912	PRP	denotes	It
T1262	1901-1908	NN	denotes	protein
T1261	1894-1900	JJ	denotes	37-kDa
T1260	1888-1893	JJ	denotes	novel
T1259	1886-1887	DT	denotes	a
T1258	1878-1885	VB	denotes	encodes
T1257	1873-1877	NN	denotes	gene
T1256	1867-1872	NN	denotes	MAPO2
T1255	1864-1865	-RRB-	denotes	)
T1254	1860-1864	CD	denotes	2012
T1253	1858-1859	-COMMA-	denotes	,
T1252	1855-1858	FW	denotes	al.
T1251	1852-1854	FW	denotes	et
T1250	1843-1851	NNP	denotes	Fujikane
T1249	1842-1843	-LRB-	denotes	(
T1248	1832-1841	NN	denotes	apoptosis
T1247	1817-1831	JJ	denotes	lesion-induced
T1246	1800-1816	NN	denotes	O6-methylguanine
T1245	1796-1799	DT	denotes	the
T1244	1793-1795	IN	denotes	in
T1243	1780-1792	VB	denotes	participates
T1242	1775-1779	NN	denotes	gene
T1241	1773-1774	-RRB-	denotes	)
T1240	1765-1773	NN	denotes	C1orf201
T1239	1764-1765	-LRB-	denotes	(
T1238	1758-1763	NN	denotes	MAPO2
T1237	1756-1757	-COMMA-	denotes	,
T1236	1752-1756	RB	denotes	Also
T1235	1749-1750	-RRB-	denotes	)
T1234	1745-1749	CD	denotes	2013
T1233	1743-1744	-COMMA-	denotes	,
T1232	1740-1743	FW	denotes	al.
T1231	1737-1739	FW	denotes	et
T1230	1728-1736	NNP	denotes	Knizhnik
T1229	1727-1728	-LRB-	denotes	(
T1228	1721-1726	NN	denotes	cells
T1227	1717-1720	NN	denotes	GBM
T1226	1714-1716	IN	denotes	in
T1225	1704-1713	NN	denotes	apoptosis
T1224	1695-1703	JJ	denotes	eventual
T1223	1691-1694	DT	denotes	the
T1222	1685-1690	VB	denotes	block
T1221	1681-1684	MD	denotes	may
T1220	1677-1680	CC	denotes	and
T1219	1675-1676	-COMMA-	denotes	,
T1218	1663-1675	JJ	denotes	pro-survival
T1217	1660-1662	VB	denotes	is
T1216	1650-1659	NN	denotes	autophagy
T1215	1638-1649	JJ	denotes	TMZ-induced
T1214	1633-1637	IN	denotes	that
T1213	1620-1632	VB	denotes	demonstrated
T1212	1614-1619	NN	denotes	study
T1211	1607-1613	JJ	denotes	recent
T1210	1605-1606	DT	denotes	a
T1209	1603-1604	-COMMA-	denotes	,
T1208	1596-1603	RB	denotes	However
T1207	1593-1594	-RRB-	denotes	)
T1206	1589-1593	CD	denotes	2010
T1205	1587-1588	-COMMA-	denotes	,
T1204	1584-1587	FW	denotes	al.
T1203	1581-1583	FW	denotes	et
T1202	1576-1580	NNP	denotes	Voss
T1201	1575-1576	-LRB-	denotes	(
T1200	1571-1574	NN	denotes	TMZ
T1199	1568-1570	IN	denotes	of
T1198	1561-1567	NN	denotes	action
T1197	1557-1560	DT	denotes	the
T1196	1548-1556	VB	denotes	enhances
T1195	1544-1547	CC	denotes	and
T1194	1536-1543	NN	denotes	gliomas
T1193	1533-1535	IN	denotes	in
T1192	1527-1532	NN	denotes	death
T1191	1516-1526	JJ	denotes	autophagic
T1190	1513-1515	TO	denotes	to
T1189	1507-1512	VB	denotes	leads
T1188	1497-1506	NN	denotes	-gossypol
T1187	1496-1497	-RRB-	denotes	)
T1186	1495-1496	LS	denotes	−
T1185	1494-1495	-LRB-	denotes	(
T1184	1484-1493	NN	denotes	inhibitor
T1183	1474-1483	NN	denotes	pan-Bcl-2
T1182	1472-1473	DT	denotes	a
T1181	1469-1471	IN	denotes	by
T1180	1463-1468	NN	denotes	Bcl-2
T1179	1449-1462	JJ	denotes	antiapoptotic
T1178	1446-1448	IN	denotes	of
T1177	1435-1445	NN	denotes	inhibition
T1176	1433-1434	-COMMA-	denotes	,
T1175	1429-1433	RB	denotes	Also
T1174	1426-1427	-RRB-	denotes	)
T1173	1422-1426	CD	denotes	2003
T1172	1420-1421	-COMMA-	denotes	,
T1171	1417-1420	FW	denotes	al.
T1170	1414-1416	FW	denotes	et
T1169	1406-1413	NNP	denotes	Kanzawa
T1168	1405-1406	-LRB-	denotes	(
T1167	1399-1404	NN	denotes	death
T1166	1394-1398	NN	denotes	cell
T1165	1388-1393	VB	denotes	cause
T1164	1385-1387	TO	denotes	to
T1163	1383-1384	-COMMA-	denotes	,
T1162	1374-1383	NN	denotes	apoptosis
T1161	1369-1373	IN	denotes	than
T1160	1362-1368	RB	denotes	rather
T1159	1360-1361	-COMMA-	denotes	,
T1158	1351-1360	NN	denotes	autophagy
T1157	1343-1350	VB	denotes	trigger
T1156	1340-1342	TO	denotes	to
T1155	1334-1339	VB	denotes	known
T1154	1331-1333	VB	denotes	is
T1153	1324-1330	NN	denotes	lesion
T1152	1307-1323	NN	denotes	O6-methylguanine
T1151	1303-1306	DT	denotes	The
T1150	1300-1301	-RRB-	denotes	)
T1149	1295-1300	NN	denotes	2012b
T1148	1293-1294	-COMMA-	denotes	,
T1147	1290-1293	FW	denotes	al.
T1146	1287-1289	FW	denotes	et
T1145	1281-1286	NNP	denotes	Zhang
T1144	1279-1280	-COLON-	denotes	;
T1143	1275-1279	CD	denotes	2011
T1142	1273-1274	-COMMA-	denotes	,
T1141	1270-1273	FW	denotes	al.
T1140	1267-1269	FW	denotes	et
T1139	1258-1266	NNP	denotes	Goellner
T1138	1257-1258	-LRB-	denotes	(
T1137	1240-1256	NN	denotes	N7-methylguanine
T1136	1236-1239	CC	denotes	and
T1135	1234-1235	-COMMA-	denotes	,
T1134	1218-1234	NN	denotes	N3-methyladenine
T1133	1216-1217	-COMMA-	denotes	,
T1132	1200-1216	NN	denotes	O6-methylguanine
T1131	1190-1199	VB	denotes	including
T1130	1188-1189	-COMMA-	denotes	,
T1129	1181-1188	NN	denotes	lesions
T1128	1177-1180	NN	denotes	DNA
T1127	1174-1176	IN	denotes	of
T1126	1163-1173	NN	denotes	generation
T1125	1155-1162	VB	denotes	induces
T1124	1142-1154	NN	denotes	Temozolomide
T1123	1139-1140	-RRB-	denotes	)
T1122	1134-1139	NN	denotes	2012b
T1121	1132-1133	-COMMA-	denotes	,
T1120	1129-1132	FW	denotes	al.
T1119	1126-1128	FW	denotes	et
T1118	1120-1125	NNP	denotes	Zhang
T1117	1118-1119	-COLON-	denotes	;
T1116	1114-1118	CD	denotes	2012
T1115	1112-1113	-COMMA-	denotes	,
T1114	1109-1112	FW	denotes	al.
T1113	1106-1108	FW	denotes	et
T1112	1098-1105	NNP	denotes	Kohsaka
T1111	1096-1097	-COLON-	denotes	;
T1110	1092-1096	CD	denotes	2012
T1109	1090-1091	-COMMA-	denotes	,
T1108	1087-1090	FW	denotes	al.
T1107	1084-1086	FW	denotes	et
T1106	1076-1083	NNP	denotes	Kitange
T1105	1074-1075	-COLON-	denotes	;
T1085	990-994	JJ	denotes	many
T1084	986-989	CC	denotes	and
T1083	984-985	-COMMA-	denotes	,
T1082	978-984	NN	denotes	kinase
T1081	972-977	NN	denotes	STAT3
T1080	970-971	-COMMA-	denotes	,
T1079	960-970	NN	denotes	transition
T1078	937-959	JJ	denotes	epithelial-mesenchymal
T1077	935-936	-COMMA-	denotes	,
T1076	922-935	NN	denotes	deacetylation
T1075	914-921	NN	denotes	histone
T1074	912-913	-COMMA-	denotes	,
T1073	905-912	NN	denotes	hypoxia
T1072	899-904	IN	denotes	under
T1071	893-898	NN	denotes	cells
T1070	887-892	NN	denotes	tumor
T1069	885-886	-COMMA-	denotes	,
T1068	879-885	NN	denotes	repair
T1067	872-878	NN	denotes	damage
T1066	868-871	NN	denotes	DNA
T1065	866-867	-COMMA-	denotes	,
T1064	860-866	NN	denotes	efflux
T1063	855-859	NN	denotes	drug
T1062	853-854	-COMMA-	denotes	,
T1061	844-853	NN	denotes	microRNAs
T1060	842-843	-COMMA-	denotes	,
T1059	837-842	NN	denotes	cells
T1058	832-836	NN	denotes	stem
T1057	825-831	NN	denotes	cancer
T1056	817-824	VB	denotes	include
T1055	813-816	MD	denotes	may
T1054	807-812	WDT	denotes	which
T1053	805-806	-COMMA-	denotes	,
T1052	795-805	NN	denotes	resistance
T1051	791-794	NN	denotes	TMZ
T1050	787-790	DT	denotes	the
T1049	784-786	IN	denotes	in
T1048	775-783	VB	denotes	involved
T1047	771-774	VB	denotes	are
T1046	760-770	NN	denotes	mechanisms
T1045	751-759	JJ	denotes	Multiple
T1044	748-749	-RRB-	denotes	)
T1043	744-748	CD	denotes	2010
T1042	742-743	-COMMA-	denotes	,
T1041	733-742	NNP	denotes	Nishikawa
T1040	731-732	-COLON-	denotes	;
T1039	727-731	CD	denotes	2000
T1038	725-726	-COMMA-	denotes	,
T1037	722-725	FW	denotes	al.
T1036	719-721	FW	denotes	et
T1035	710-718	NNP	denotes	Friedman
T1034	709-710	-LRB-	denotes	(
T1033	707-708	-RRB-	denotes	)
T1338	2347-2352	NN	denotes	death
T1337	2342-2346	NN	denotes	cell
T1336	2332-2341	JJ	denotes	apoptotic
T1335	2329-2331	TO	denotes	to
T1334	2323-2328	VB	denotes	leads
T1333	2312-2322	RB	denotes	ultimately
T1332	2307-2311	WDT	denotes	that
T1331	2300-2306	NN	denotes	kinase
T1330	2292-2299	NN	denotes	protein
T1329	2279-2291	JJ	denotes	Rad3-related
T1328	2276-2278	CC	denotes	or
T1327	2267-2275	NN	denotes	proteins
T1326	2265-2266	-RRB-	denotes	)
T1325	2262-2265	NN	denotes	MMR
T1324	2261-2262	-LRB-	denotes	(
T1323	2244-2260	JJ	denotes	repair-deficient
T1322	2235-2243	NN	denotes	mismatch
T1321	2232-2234	IN	denotes	of
T1032	704-707	NN	denotes	TMZ
T1031	703-704	-LRB-	denotes	(
T1030	690-702	NN	denotes	temozolomide
T1029	684-689	NN	denotes	agent
T1028	673-683	VB	denotes	alkylating
T1027	658-672	JJ	denotes	monofunctional
T1026	654-657	DT	denotes	the
T1025	649-653	IN	denotes	with
T1024	639-648	NN	denotes	treatment
T1023	635-638	CC	denotes	and
T1022	633-634	-COMMA-	denotes	,
T1021	624-633	NN	denotes	radiation
T1020	622-623	-COMMA-	denotes	,
T1019	615-622	NN	denotes	surgery
T1018	605-614	VB	denotes	debulking
T1017	597-604	JJ	denotes	maximum
T1016	588-596	VB	denotes	includes
T1015	581-587	RB	denotes	mainly
T1014	577-580	NN	denotes	GBM
T1013	573-576	IN	denotes	for
T1012	565-572	NN	denotes	therapy
T1011	556-564	JJ	denotes	standard
T1010	548-555	JJ	denotes	current
T1009	544-547	DT	denotes	The
T1008	541-542	-RRB-	denotes	)
T1007	537-541	CD	denotes	2012
T1006	535-536	-COMMA-	denotes	,
T1005	532-535	FW	denotes	al.
T1004	529-531	FW	denotes	et
T1003	521-528	NNP	denotes	Happold
T1002	519-520	-COLON-	denotes	;
T1001	515-519	CD	denotes	2012
T1000	513-514	-COMMA-	denotes	,
T999	510-513	FW	denotes	al.
T998	507-509	FW	denotes	et
T997	502-506	NNP	denotes	Haar
T996	501-502	-LRB-	denotes	(
T995	492-500	NN	denotes	patients
T994	489-491	IN	denotes	in
T993	484-488	VB	denotes	seen
T992	473-483	RB	denotes	frequently
T991	469-472	VB	denotes	are
T990	461-468	NN	denotes	relapse
T989	454-460	NN	denotes	cancer
T988	450-453	CC	denotes	and
T987	439-449	NN	denotes	modalities
T986	427-438	JJ	denotes	therapeutic
T985	419-426	JJ	denotes	current
T984	416-418	TO	denotes	to
T983	405-415	NN	denotes	resistance
T982	402-404	IN	denotes	of
T981	395-401	NN	denotes	levels
T980	390-394	JJ	denotes	High
T979	387-388	-RRB-	denotes	)
T978	383-387	CD	denotes	2009
T977	381-382	-COMMA-	denotes	,
T976	378-381	FW	denotes	al.
T975	375-377	FW	denotes	et
T974	369-374	NNP	denotes	Stupp
T973	367-368	-COLON-	denotes	;
T972	363-367	CD	denotes	2000
T971	361-362	-COMMA-	denotes	,
T970	358-361	FW	denotes	al.
T969	355-357	FW	denotes	et
T968	346-354	NNP	denotes	Friedman
T967	345-346	-LRB-	denotes	(
T966	343-344	NN	denotes	%
T965	340-343	CD	denotes	9.8
T964	335-339	RB	denotes	only
T963	332-334	VB	denotes	is
T962	328-331	NN	denotes	GBM
T961	324-327	IN	denotes	for
T960	319-323	NN	denotes	rate
T959	310-318	NN	denotes	survival
T958	303-309	JJ	denotes	5-year
T957	295-302	JJ	denotes	overall
T956	291-294	DT	denotes	the
T955	287-290	CC	denotes	and
T954	285-286	-COMMA-	denotes	,
T953	274-285	NN	denotes	14.6 months
T952	271-273	VB	denotes	is
T951	260-270	NN	denotes	expectancy
T950	251-259	NN	denotes	survival
T949	243-250	JJ	denotes	average
T948	239-242	DT	denotes	the
T947	235-238	CC	denotes	and
T946	233-234	-COMMA-	denotes	,
T945	227-233	JJ	denotes	lethal
T944	220-226	RB	denotes	highly
T943	217-219	VB	denotes	is
T942	215-216	-RRB-	denotes	)
T941	212-215	NN	denotes	GBM
T940	211-212	-LRB-	denotes	(
T939	198-210	NN	denotes	Glioblastoma
T938	195-196	-RRB-	denotes	)
T937	191-195	CD	denotes	2012
T936	189-190	-COMMA-	denotes	,
T935	186-189	FW	denotes	al.
T934	183-185	FW	denotes	et
T933	176-182	NNP	denotes	Silber
T932	174-175	-COLON-	denotes	;
T931	170-174	CD	denotes	2009
T930	168-169	-COMMA-	denotes	,
T929	165-168	FW	denotes	al.
T928	162-164	FW	denotes	et
T927	156-161	NNP	denotes	Stupp
T926	154-155	-COLON-	denotes	;
T925	150-154	CD	denotes	2000
T924	148-149	-COMMA-	denotes	,
T923	145-148	FW	denotes	al.
T922	142-144	FW	denotes	et
T921	133-141	NNP	denotes	Friedman
T920	132-133	-LRB-	denotes	(
T919	123-131	RB	denotes	annually
T918	118-122	NNP	denotes	U.S.
T917	114-117	DT	denotes	the
T916	111-113	IN	denotes	in
T915	102-110	NN	denotes	patients
T914	98-101	JJ	denotes	new
T913	91-97	CD	denotes	12,500
T912	82-90	NN	denotes	afflicts
T911	71-81	JJ	denotes	multiforme
T1104	1070-1074	CD	denotes	2012
T1103	1068-1069	-COMMA-	denotes	,
T1102	1060-1068	NNP	denotes	Bjerkvig
T1101	1056-1059	CC	denotes	and
T1100	1044-1055	NNP	denotes	Johannessen
T1099	1042-1043	-COLON-	denotes	;
T1098	1038-1042	CD	denotes	2012
T1097	1036-1037	-COMMA-	denotes	,
T1096	1033-1036	FW	denotes	al.
T1095	1030-1032	FW	denotes	et
T1094	1022-1029	NNP	denotes	Happold
T1093	1020-1021	-COLON-	denotes	;
T1092	1016-1020	CD	denotes	2012
T1091	1014-1015	-COMMA-	denotes	,
T1090	1011-1014	FW	denotes	al.
T1089	1008-1010	FW	denotes	et
T1088	1003-1007	NNP	denotes	Haar
T1087	1002-1003	-LRB-	denotes	(
T910	58-70	NN	denotes	Glioblastoma
R1378	T1834	T1835	arg1Of	complicated,than
R466	T915	T912	arg1Of	patients,afflicts
R467	T915	T913	arg1Of	patients,"12,500"
R468	T915	T914	arg1Of	patients,new
R469	T915	T916	arg1Of	patients,in
R470	T915	T919	arg1Of	patients,annually
R471	T915	T920	arg1Of	patients,(
R472	T918	T916	arg2Of	U.S.,in
R473	T918	T917	arg1Of	U.S.,the
R475	T921	T922	arg1Of	Friedman,et
R476	T921	T923	arg1Of	Friedman,al.
R477	T921	T924	arg1Of	Friedman,","
R478	T921	T926	arg1Of	Friedman,;
R479	T921	T932	arg1Of	Friedman,;
R480	T925	T924	arg2Of	2000,","
R481	T927	T926	arg2Of	Stupp,;
R482	T927	T928	arg1Of	Stupp,et
R483	T927	T929	arg1Of	Stupp,al.
R484	T927	T930	arg1Of	Stupp,","
R485	T931	T930	arg2Of	2009,","
R486	T933	T932	arg2Of	Silber,;
R487	T933	T934	arg1Of	Silber,et
R488	T933	T935	arg1Of	Silber,al.
R489	T933	T936	arg1Of	Silber,","
R490	T937	T936	arg2Of	2012,","
R492	T939	T940	arg1Of	Glioblastoma,(
R493	T939	T943	arg1Of	Glioblastoma,is
R494	T939	T945	arg1Of	Glioblastoma,lethal
R495	T941	T940	arg2Of	GBM,(
R496	T942	T940	arg3Of	),(
R497	T943	T947	arg1Of	is,and
R498	T945	T943	arg2Of	lethal,is
R499	T945	T944	arg1Of	lethal,highly
R500	T947	T946	arg1Of	and,","
R501	T947	T955	arg1Of	and,and
R502	T951	T948	arg1Of	expectancy,the
R503	T951	T949	arg1Of	expectancy,average
R504	T951	T950	arg1Of	expectancy,survival
R505	T951	T952	arg1Of	expectancy,is
R506	T951	T953	arg1Of	expectancy,14.6 months
R507	T952	T947	arg2Of	is,and
R508	T953	T952	arg2Of	14.6 months,is
R509	T955	T954	arg1Of	and,","
R510	T960	T956	arg1Of	rate,the
R511	T960	T957	arg1Of	rate,overall
R512	T960	T958	arg1Of	rate,5-year
R513	T960	T959	arg1Of	rate,survival
R514	T960	T961	arg1Of	rate,for
R515	T960	T963	arg1Of	rate,is
R516	T962	T961	arg2Of	GBM,for
R517	T963	T955	arg2Of	is,and
R518	T963	T967	arg1Of	is,(
R519	T965	T964	arg1Of	9.8,only
R520	T966	T963	arg2Of	%,is
R521	T966	T965	arg1Of	%,9.8
R522	T968	T967	arg2Of	Friedman,(
R523	T968	T969	arg1Of	Friedman,et
R524	T968	T970	arg1Of	Friedman,al.
R525	T968	T971	arg1Of	Friedman,","
R526	T968	T973	arg1Of	Friedman,;
R527	T972	T971	arg2Of	2000,","
R528	T974	T973	arg2Of	Stupp,;
R529	T974	T975	arg1Of	Stupp,et
R530	T974	T976	arg1Of	Stupp,al.
R531	T974	T977	arg1Of	Stupp,","
R532	T978	T977	arg2Of	2009,","
R533	T979	T967	arg3Of	),(
R534	T981	T980	arg1Of	levels,High
R535	T981	T982	arg1Of	levels,of
R536	T981	T991	arg1Of	levels,are
R537	T981	T993	arg2Of	levels,seen
R538	T983	T984	arg1Of	resistance,to
R539	T983	T988	arg1Of	resistance,and
R540	T987	T984	arg2Of	modalities,to
R541	T987	T985	arg1Of	modalities,current
R542	T987	T986	arg1Of	modalities,therapeutic
R543	T988	T982	arg2Of	and,of
R544	T990	T988	arg2Of	relapse,and
R545	T990	T989	arg1Of	relapse,cancer
R546	T993	T991	arg2Of	seen,are
R547	T993	T992	arg1Of	seen,frequently
R548	T993	T994	arg1Of	seen,in
R549	T993	T996	arg1Of	seen,(
R550	T995	T994	arg2Of	patients,in
R551	T997	T996	arg2Of	Haar,(
R552	T997	T998	arg1Of	Haar,et
R553	T997	T999	arg1Of	Haar,al.
R554	T997	T1000	arg1Of	Haar,","
R555	T997	T1002	arg1Of	Haar,;
R556	T1001	T1000	arg2Of	2012,","
R557	T1003	T1002	arg2Of	Happold,;
R558	T1003	T1004	arg1Of	Happold,et
R559	T1003	T1005	arg1Of	Happold,al.
R560	T1003	T1006	arg1Of	Happold,","
R561	T1007	T1006	arg2Of	2012,","
R562	T1008	T996	arg3Of	),(
R567	T1012	T1009	arg1Of	therapy,The
R572	T1019	T1020	arg1Of	surgery,","
R573	T1020	T1023	arg1Of	",",and
R574	T1021	T1020	arg2Of	radiation,","
R575	T1023	T1016	arg2Of	and,includes
R576	T1023	T1022	arg1Of	and,","
R577	T1024	T1023	arg2Of	treatment,and
R578	T1024	T1025	arg1Of	treatment,with
R579	T1030	T1025	arg2Of	temozolomide,with
R580	T1030	T1026	arg1Of	temozolomide,the
R581	T1030	T1027	arg1Of	temozolomide,monofunctional
R582	T1030	T1028	arg1Of	temozolomide,alkylating
R583	T1030	T1029	arg1Of	temozolomide,agent
R584	T1030	T1031	arg1Of	temozolomide,(
R585	T1030	T1034	arg1Of	temozolomide,(
R586	T1032	T1031	arg2Of	TMZ,(
R587	T1033	T1031	arg3Of	),(
R588	T1035	T1034	arg2Of	Friedman,(
R589	T1035	T1036	arg1Of	Friedman,et
R590	T1035	T1037	arg1Of	Friedman,al.
R591	T1035	T1038	arg1Of	Friedman,","
R592	T1035	T1040	arg1Of	Friedman,;
R593	T1039	T1038	arg2Of	2000,","
R594	T1041	T1040	arg2Of	Nishikawa,;
R595	T1041	T1042	arg1Of	Nishikawa,","
R596	T1043	T1042	arg2Of	2010,","
R597	T1044	T1034	arg3Of	),(
R598	T1046	T1045	arg1Of	mechanisms,Multiple
R599	T1046	T1047	arg1Of	mechanisms,are
R600	T1046	T1048	arg2Of	mechanisms,involved
R601	T1048	T1047	arg2Of	involved,are
R602	T1048	T1049	arg1Of	involved,in
R603	T1052	T1049	arg2Of	resistance,in
R604	T1052	T1050	arg1Of	resistance,the
R605	T1052	T1051	arg1Of	resistance,TMZ
R606	T1052	T1053	arg1Of	resistance,","
R607	T1052	T1054	arg1Of	resistance,which
R608	T1052	T1055	arg1Of	resistance,may
R609	T1052	T1056	arg1Of	resistance,include
R610	T1056	T1055	arg2Of	include,may
R611	T1059	T1057	arg1Of	cells,cancer
R612	T1059	T1058	arg1Of	cells,stem
R613	T1059	T1060	arg1Of	cells,","
R614	T1060	T1062	arg1Of	",",","
R615	T1061	T1060	arg2Of	microRNAs,","
R616	T1062	T1065	arg1Of	",",","
R617	T1064	T1062	arg2Of	efflux,","
R618	T1064	T1063	arg1Of	efflux,drug
R619	T1065	T1069	arg1Of	",",","
R620	T1068	T1065	arg2Of	repair,","
R621	T1068	T1066	arg1Of	repair,DNA
R622	T1068	T1067	arg1Of	repair,damage
R623	T1069	T1056	arg2Of	",",include
R624	T1069	T1072	arg1Of	",",under
R625	T1071	T1069	arg2Of	cells,","
R626	T1071	T1070	arg1Of	cells,tumor
R627	T1073	T1074	arg1Of	hypoxia,","
R628	T1074	T1077	arg1Of	",",","
R629	T1076	T1074	arg2Of	deacetylation,","
R630	T1076	T1075	arg1Of	deacetylation,histone
R631	T1077	T1080	arg1Of	",",","
R632	T1079	T1077	arg2Of	transition,","
R633	T1079	T1078	arg1Of	transition,epithelial-mesenchymal
R634	T1080	T1084	arg1Of	",",and
R635	T1082	T1080	arg2Of	kinase,","
R636	T1082	T1081	arg1Of	kinase,STAT3
R637	T1084	T1072	arg2Of	and,under
R638	T1084	T1083	arg1Of	and,","
R639	T1086	T1084	arg2Of	others,and
R640	T1086	T1085	arg1Of	others,many
R641	T1086	T1087	arg1Of	others,(
R642	T1088	T1087	arg2Of	Haar,(
R643	T1088	T1089	arg1Of	Haar,et
R644	T1088	T1090	arg1Of	Haar,al.
R645	T1088	T1091	arg1Of	Haar,","
R646	T1088	T1093	arg1Of	Haar,;
R647	T1088	T1099	arg1Of	Haar,;
R648	T1092	T1091	arg2Of	2012,","
R649	T1094	T1093	arg2Of	Happold,;
R650	T1094	T1095	arg1Of	Happold,et
R651	T1094	T1096	arg1Of	Happold,al.
R652	T1094	T1097	arg1Of	Happold,","
R653	T1098	T1097	arg2Of	2012,","
R654	T1100	T1101	arg1Of	Johannessen,and
R655	T1101	T1099	arg2Of	and,;
R656	T1101	T1103	arg1Of	and,","
R657	T1101	T1105	arg1Of	and,;
R658	T1101	T1111	arg1Of	and,;
R659	T1102	T1101	arg2Of	Bjerkvig,and
R660	T1104	T1103	arg2Of	2012,","
R661	T1106	T1105	arg2Of	Kitange,;
R662	T1106	T1107	arg1Of	Kitange,et
R663	T1106	T1108	arg1Of	Kitange,al.
R664	T1106	T1109	arg1Of	Kitange,","
R665	T1110	T1109	arg2Of	2012,","
R666	T1112	T1111	arg2Of	Kohsaka,;
R667	T1112	T1113	arg1Of	Kohsaka,et
R668	T1112	T1114	arg1Of	Kohsaka,al.
R669	T1112	T1115	arg1Of	Kohsaka,","
R670	T1112	T1117	arg1Of	Kohsaka,;
R671	T1116	T1115	arg2Of	2012,","
R672	T1118	T1117	arg2Of	Zhang,;
R673	T1118	T1119	arg1Of	Zhang,et
R674	T1118	T1120	arg1Of	Zhang,al.
R675	T1118	T1121	arg1Of	Zhang,","
R676	T1122	T1121	arg2Of	2012b,","
R677	T1123	T1087	arg3Of	),(
R678	T1124	T1125	arg1Of	Temozolomide,induces
R679	T1126	T1125	arg2Of	generation,induces
R680	T1126	T1127	arg1Of	generation,of
R681	T1129	T1127	arg2Of	lesions,of
R682	T1129	T1128	arg1Of	lesions,DNA
R683	T1129	T1130	arg1Of	lesions,","
R684	T1129	T1131	arg1Of	lesions,including
R685	T1132	T1133	arg1Of	O6-methylguanine,","
R686	T1133	T1136	arg1Of	",",and
R687	T1134	T1133	arg2Of	N3-methyladenine,","
R688	T1136	T1131	arg2Of	and,including
R689	T1136	T1135	arg1Of	and,","
R690	T1136	T1138	arg1Of	and,(
R691	T1137	T1136	arg2Of	N7-methylguanine,and
R692	T1139	T1138	arg2Of	Goellner,(
R693	T1139	T1140	arg1Of	Goellner,et
R694	T1139	T1141	arg1Of	Goellner,al.
R695	T1139	T1142	arg1Of	Goellner,","
R696	T1139	T1144	arg1Of	Goellner,;
R697	T1143	T1142	arg2Of	2011,","
R698	T1145	T1144	arg2Of	Zhang,;
R699	T1145	T1146	arg1Of	Zhang,et
R700	T1145	T1147	arg1Of	Zhang,al.
R701	T1145	T1148	arg1Of	Zhang,","
R702	T1149	T1148	arg2Of	2012b,","
R703	T1150	T1138	arg3Of	),(
R704	T1153	T1151	arg1Of	lesion,The
R705	T1153	T1152	arg1Of	lesion,O6-methylguanine
R706	T1153	T1154	arg1Of	lesion,is
R707	T1153	T1155	arg2Of	lesion,known
R708	T1153	T1157	arg1Of	lesion,trigger
R709	T1155	T1154	arg2Of	known,is
R710	T1157	T1155	arg3Of	trigger,known
R711	T1157	T1156	arg1Of	trigger,to
R712	T1157	T1163	arg1Of	trigger,","
R713	T1157	T1164	modOf	trigger,to
R714	T1157	T1168	arg1Of	trigger,(
R715	T1158	T1161	arg1Of	autophagy,than
R716	T1161	T1157	arg2Of	than,trigger
R717	T1161	T1159	arg1Of	than,","
R718	T1161	T1160	arg1Of	than,rather
R719	T1162	T1161	arg2Of	apoptosis,than
R720	T1165	T1164	arg1Of	cause,to
R721	T1167	T1165	arg2Of	death,cause
R722	T1167	T1166	arg1Of	death,cell
R723	T1169	T1168	arg2Of	Kanzawa,(
R724	T1169	T1170	arg1Of	Kanzawa,et
R725	T1169	T1171	arg1Of	Kanzawa,al.
R726	T1169	T1172	arg1Of	Kanzawa,","
R727	T1173	T1172	arg2Of	2003,","
R728	T1174	T1168	arg3Of	),(
R729	T1177	T1178	arg1Of	inhibition,of
R730	T1177	T1181	arg1Of	inhibition,by
R731	T1177	T1189	arg1Of	inhibition,leads
R732	T1177	T1196	arg1Of	inhibition,enhances
R733	T1180	T1178	arg2Of	Bcl-2,of
R734	T1180	T1179	arg1Of	Bcl-2,antiapoptotic
R735	T1184	T1182	arg1Of	inhibitor,a
R736	T1184	T1183	arg1Of	inhibitor,pan-Bcl-2
R737	T1186	T1184	arg1Of	−,inhibitor
R738	T1186	T1185	arg1Of	−,(
R739	T1186	T1187	arg1Of	−,)
R740	T1188	T1181	arg2Of	-gossypol,by
R741	T1188	T1186	arg1Of	-gossypol,−
R742	T1189	T1190	arg1Of	leads,to
R743	T1189	T1195	arg1Of	leads,and
R744	T1192	T1190	arg2Of	death,to
R745	T1192	T1191	arg1Of	death,autophagic
R746	T1192	T1193	arg1Of	death,in
R747	T1194	T1193	arg2Of	gliomas,in
R748	T1195	T1175	arg1Of	and,Also
R749	T1195	T1176	arg1Of	and,","
R750	T1196	T1195	arg2Of	enhances,and
R751	T1196	T1201	arg1Of	enhances,(
R752	T1198	T1196	arg2Of	action,enhances
R753	T1198	T1197	arg1Of	action,the
R754	T1198	T1199	arg1Of	action,of
R755	T1200	T1199	arg2Of	TMZ,of
R756	T1202	T1201	arg2Of	Voss,(
R757	T1202	T1203	arg1Of	Voss,et
R758	T1202	T1204	arg1Of	Voss,al.
R759	T1202	T1205	arg1Of	Voss,","
R760	T1206	T1205	arg2Of	2010,","
R761	T1207	T1201	arg3Of	),(
R762	T1212	T1210	arg1Of	study,a
R763	T1212	T1211	arg1Of	study,recent
R764	T1212	T1213	arg1Of	study,demonstrated
R765	T1213	T1208	arg1Of	demonstrated,However
R766	T1213	T1209	arg1Of	demonstrated,","
R767	T1216	T1215	arg1Of	autophagy,TMZ-induced
R768	T1216	T1217	arg1Of	autophagy,is
R769	T1216	T1218	arg1Of	autophagy,pro-survival
R770	T1216	T1221	arg1Of	autophagy,may
R771	T1216	T1222	arg1Of	autophagy,block
R772	T1217	T1220	arg1Of	is,and
R773	T1218	T1217	arg2Of	pro-survival,is
R774	T1220	T1213	arg2Of	and,demonstrated
R775	T1220	T1214	arg1Of	and,that
R776	T1220	T1219	arg1Of	and,","
R777	T1222	T1220	arg2Of	block,and
R778	T1222	T1221	arg2Of	block,may
R779	T1222	T1229	arg1Of	block,(
R780	T1225	T1222	arg2Of	apoptosis,block
R781	T1225	T1223	arg1Of	apoptosis,the
R782	T1225	T1224	arg1Of	apoptosis,eventual
R783	T1225	T1226	arg1Of	apoptosis,in
R784	T1228	T1226	arg2Of	cells,in
R785	T1228	T1227	arg1Of	cells,GBM
R786	T1230	T1229	arg2Of	Knizhnik,(
R787	T1230	T1231	arg1Of	Knizhnik,et
R788	T1230	T1232	arg1Of	Knizhnik,al.
R789	T1230	T1233	arg1Of	Knizhnik,","
R790	T1234	T1233	arg2Of	2013,","
R791	T1235	T1229	arg3Of	),(
R792	T1240	T1239	arg2Of	C1orf201,(
R793	T1241	T1239	arg3Of	),(
R794	T1242	T1238	arg1Of	gene,MAPO2
R795	T1242	T1239	arg1Of	gene,(
R796	T1242	T1243	arg1Of	gene,participates
R797	T1243	T1236	arg1Of	participates,Also
R798	T1243	T1237	arg1Of	participates,","
R799	T1243	T1244	arg1Of	participates,in
R800	T1243	T1249	arg1Of	participates,(
R801	T1248	T1244	arg2Of	apoptosis,in
R802	T1248	T1245	arg1Of	apoptosis,the
R803	T1248	T1246	arg1Of	apoptosis,O6-methylguanine
R804	T1248	T1247	arg1Of	apoptosis,lesion-induced
R805	T1250	T1249	arg2Of	Fujikane,(
R806	T1250	T1251	arg1Of	Fujikane,et
R807	T1250	T1252	arg1Of	Fujikane,al.
R808	T1250	T1253	arg1Of	Fujikane,","
R809	T1254	T1253	arg2Of	2012,","
R810	T1255	T1249	arg3Of	),(
R811	T1257	T1256	arg1Of	gene,MAPO2
R812	T1257	T1258	arg1Of	gene,encodes
R813	T1262	T1258	arg2Of	protein,encodes
R814	T1262	T1259	arg1Of	protein,a
R815	T1262	T1260	arg1Of	protein,novel
R816	T1262	T1261	arg1Of	protein,37-kDa
R817	T1263	T1264	arg1Of	It,is
R818	T1263	T1266	arg2Of	It,determined
R819	T1266	T1264	arg2Of	determined,is
R820	T1266	T1265	arg1Of	determined,not
R821	T1266	T1267	arg1Of	determined,whether
R822	T1269	T1268	arg1Of	gene,this
R823	T1269	T1270	arg1Of	gene,is
R824	T1269	T1271	arg2Of	gene,involved
R825	T1271	T1267	arg2Of	involved,whether
R826	T1271	T1270	arg2Of	involved,is
R827	T1271	T1272	arg1Of	involved,in
R828	T1273	T1272	arg2Of	autophagy,in
R829	T1276	T1274	arg1Of	lesion,The
R830	T1276	T1275	arg1Of	lesion,O6-methylguanine
R831	T1276	T1277	arg1Of	lesion,is
R832	T1277	T1289	arg1Of	is,(
R833	T1279	T1277	arg2Of	substrate,is
R834	T1279	T1278	arg1Of	substrate,a
R835	T1279	T1280	arg1Of	substrate,for
R836	T1279	T1283	arg1Of	substrate,by
R837	T1282	T1280	arg2Of	repair,for
R838	T1282	T1281	arg1Of	repair,direct
R839	T1285	T1283	arg2Of	methyltransferase,by
R840	T1285	T1284	arg1Of	methyltransferase,O6-methylguanine-DNA
R841	T1285	T1286	arg1Of	methyltransferase,(
R842	T1287	T1286	arg2Of	MGMT,(
R843	T1288	T1286	arg3Of	),(
R844	T1290	T1289	arg2Of	Pollack,(
R845	T1290	T1291	arg1Of	Pollack,et
R846	T1290	T1292	arg1Of	Pollack,al.
R847	T1290	T1293	arg1Of	Pollack,","
R848	T1290	T1295	arg1Of	Pollack,;
R849	T1290	T1301	arg1Of	Pollack,;
R850	T1294	T1293	arg2Of	2006,","
R851	T1296	T1295	arg2Of	Hegi,;
R852	T1296	T1297	arg1Of	Hegi,et
R853	T1296	T1298	arg1Of	Hegi,al.
R854	T1296	T1299	arg1Of	Hegi,","
R855	T1300	T1299	arg2Of	2008,","
R856	T1302	T1301	arg2Of	Fukushima,;
R857	T1302	T1303	arg1Of	Fukushima,et
R858	T1302	T1304	arg1Of	Fukushima,al.
R859	T1302	T1305	arg1Of	Fukushima,","
R860	T1302	T1307	arg1Of	Fukushima,;
R861	T1306	T1305	arg2Of	2009,","
R862	T1308	T1307	arg2Of	Zhang,;
R863	T1308	T1309	arg1Of	Zhang,et
R864	T1308	T1310	arg1Of	Zhang,al.
R865	T1308	T1311	arg1Of	Zhang,","
R866	T1312	T1311	arg2Of	2012b,","
R867	T1313	T1289	arg3Of	),(
R868	T1316	T1314	arg2Of	repair,Without
R869	T1316	T1315	arg1Of	repair,MGMT
R870	T1318	T1319	arg1Of	O6-methylguanine,initiates
R871	T1319	T1314	arg1Of	initiates,Without
R872	T1319	T1317	arg1Of	initiates,","
R873	T1320	T1321	arg1Of	activation,of
R874	T1320	T1328	arg1Of	activation,or
R875	T1325	T1324	arg2Of	MMR,(
R876	T1326	T1324	arg3Of	),(
R877	T1327	T1321	arg2Of	proteins,of
R878	T1327	T1322	arg1Of	proteins,mismatch
R879	T1327	T1323	arg1Of	proteins,repair-deficient
R880	T1327	T1324	arg1Of	proteins,(
R881	T1328	T1319	arg2Of	or,initiates
R882	T1331	T1328	arg2Of	kinase,or
R883	T1331	T1329	arg1Of	kinase,Rad3-related
R884	T1331	T1330	arg1Of	kinase,protein
R885	T1331	T1332	arg1Of	kinase,that
R886	T1331	T1334	arg1Of	kinase,leads
R887	T1334	T1333	arg1Of	leads,ultimately
R888	T1334	T1335	arg1Of	leads,to
R889	T1334	T1339	arg1Of	leads,(
R890	T1338	T1335	arg2Of	death,to
R891	T1338	T1336	arg1Of	death,apoptotic
R892	T1338	T1337	arg1Of	death,cell
R893	T1340	T1339	arg2Of	Caporali,(
R894	T1340	T1341	arg1Of	Caporali,et
R895	T1340	T1342	arg1Of	Caporali,al.
R896	T1340	T1343	arg1Of	Caporali,","
R897	T1340	T1345	arg1Of	Caporali,;
R898	T1340	T1351	arg1Of	Caporali,;
R899	T1344	T1343	arg2Of	2004,","
R900	T1346	T1347	arg1Of	Wang,and
R901	T1347	T1345	arg2Of	and,;
R902	T1347	T1349	arg1Of	and,","
R903	T1348	T1347	arg2Of	Edelmann,and
R904	T1350	T1349	arg2Of	2006,","
R905	T1352	T1351	arg2Of	Roos,;
R906	T1352	T1353	arg1Of	Roos,et
R907	T1352	T1354	arg1Of	Roos,al.
R908	T1352	T1355	arg1Of	Roos,","
R909	T1356	T1355	arg2Of	2007,","
R910	T1357	T1339	arg3Of	),(
R911	T1359	T1358	arg1Of	expression,High
R912	T1359	T1360	arg1Of	expression,of
R913	T1359	T1366	arg1Of	expression,contributes
R914	T1361	T1362	arg1Of	MGMT,or
R915	T1362	T1360	arg2Of	or,of
R916	T1363	T1362	arg2Of	loss,or
R917	T1363	T1364	arg1Of	loss,of
R918	T1365	T1364	arg2Of	MMR,of
R919	T1366	T1367	arg1Of	contributes,significantly
R920	T1366	T1368	arg1Of	contributes,to
R921	T1366	T1371	arg1Of	contributes,in
R922	T1366	T1375	arg1Of	contributes,(
R923	T1370	T1368	arg2Of	resistance,to
R924	T1370	T1369	arg1Of	resistance,TMZ
R925	T1374	T1371	arg2Of	cases,in
R926	T1374	T1372	arg1Of	cases,many
R927	T1374	T1373	arg1Of	cases,clinical
R928	T1376	T1375	arg2Of	Pollack,(
R929	T1376	T1377	arg1Of	Pollack,et
R930	T1376	T1378	arg1Of	Pollack,al.
R931	T1376	T1379	arg1Of	Pollack,","
R932	T1376	T1381	arg1Of	Pollack,;
R933	T1376	T1387	arg1Of	Pollack,;
R934	T1380	T1379	arg2Of	2006,","
R935	T1382	T1381	arg2Of	Hegi,;
R936	T1382	T1383	arg1Of	Hegi,et
R937	T1382	T1384	arg1Of	Hegi,al.
R938	T1382	T1385	arg1Of	Hegi,","
R939	T1386	T1385	arg2Of	2008,","
R940	T1388	T1387	arg2Of	Sarkaria,;
R941	T1388	T1389	arg1Of	Sarkaria,et
R942	T1388	T1390	arg1Of	Sarkaria,al.
R943	T1388	T1391	arg1Of	Sarkaria,","
R944	T1392	T1391	arg2Of	2008,","
R945	T1393	T1375	arg3Of	),(
R946	T1395	T1394	arg1Of	initiation,The
R947	T1395	T1396	arg1Of	initiation,of
R948	T1395	T1399	arg1Of	initiation,fails
R949	T1398	T1396	arg2Of	signaling,of
R950	T1398	T1397	arg1Of	signaling,apoptotic
R951	T1399	T1400	arg1Of	fails,in
R952	T1400	T1401	arg1Of	in,the
R953	T1400	T1403	arg1Of	in,of
R954	T1402	T1400	arg2Of	absence,in
R955	T1406	T1400	arg3Of	system,in
R956	T1406	T1404	arg1Of	system,the
R957	T1406	T1405	arg1Of	system,MMR
R958	T1407	T1408	arg1Of	Sensitivity,to
R959	T1407	T1410	arg1Of	Sensitivity,is
R960	T1407	T1412	arg2Of	Sensitivity,associated
R961	T1409	T1408	arg2Of	TMZ,to
R962	T1412	T1410	arg2Of	associated,is
R963	T1412	T1411	arg1Of	associated,significantly
R964	T1412	T1413	arg1Of	associated,with
R965	T1416	T1413	arg2Of	status,with
R966	T1416	T1414	arg1Of	status,the
R967	T1416	T1415	arg1Of	status,methylation
R968	T1416	T1417	arg1Of	status,of
R969	T1420	T1417	arg2Of	promoter,of
R970	T1420	T1418	arg1Of	promoter,MGMT
R971	T1420	T1419	arg1Of	promoter,gene
R972	T1420	T1421	arg1Of	promoter,in
R973	T1422	T1421	arg2Of	cells,in
R974	T1422	T1423	arg2Of	cells,committed
R975	T1423	T1424	arg1Of	committed,to
R976	T1425	T1424	arg2Of	differentiation,to
R977	T1425	T1426	arg1Of	differentiation,(
R978	T1429	T1426	arg2Of	al.,(
R979	T1429	T1427	arg1Of	al.,Villalva
R980	T1429	T1428	arg1Of	al.,et
R981	T1429	T1430	arg1Of	al.,","
R982	T1431	T1430	arg2Of	2012,","
R983	T1432	T1426	arg3Of	),(
R984	T1434	T1433	arg1Of	increase,An
R985	T1434	T1435	arg1Of	increase,in
R986	T1434	T1440	arg1Of	increase,","
R987	T1434	T1441	arg1Of	increase,which
R988	T1434	T1442	arg1Of	increase,blocks
R989	T1434	T1447	arg1Of	increase,prolongs
R990	T1439	T1435	arg2Of	methylation,in
R991	T1439	T1436	arg1Of	methylation,MGMT
R992	T1439	T1437	arg1Of	methylation,gene
R993	T1439	T1438	arg1Of	methylation,promoter
R994	T1445	T1442	arg2Of	expression,blocks
R995	T1445	T1443	arg1Of	expression,MGMT
R996	T1445	T1444	arg1Of	expression,protein
R997	T1447	T1446	arg1Of	prolongs,","
R998	T1450	T1447	arg2Of	survival,prolongs
R999	T1450	T1448	arg1Of	survival,cancer
R1000	T1450	T1449	arg1Of	survival,patient
R1001	T1454	T1453	arg2Of	microRNA-21,overexpressed
R1002	T1454	T1455	arg1Of	microRNA-21,reduces
R1003	T1455	T1451	arg1Of	reduces,Intriguingly
R1004	T1455	T1452	arg1Of	reduces,","
R1005	T1455	T1461	arg1Of	reduces,","
R1006	T1455	T1463	modOf	reduces,blocking
R1007	T1457	T1456	arg1Of	ratio,Bax/Bcl-2
R1008	T1457	T1458	arg1Of	ratio,and
R1009	T1458	T1455	arg2Of	and,reduces
R1010	T1460	T1458	arg2Of	activity,and
R1011	T1460	T1459	arg1Of	activity,caspase-3
R1012	T1463	T1462	arg1Of	blocking,thereby
R1013	T1465	T1463	arg2Of	apoptosis,blocking
R1014	T1465	T1464	arg1Of	apoptosis,TMZ-induced
R1015	T1465	T1466	arg1Of	apoptosis,(
R1016	T1467	T1466	arg2Of	Shi,(
R1017	T1467	T1468	arg1Of	Shi,et
R1018	T1467	T1469	arg1Of	Shi,al.
R1019	T1467	T1470	arg1Of	Shi,","
R1020	T1471	T1470	arg2Of	2010,","
R1021	T1472	T1466	arg3Of	),(
R1022	T1473	T1474	arg1Of	MicroRNA-21,is
R1023	T1473	T1475	arg2Of	MicroRNA-21,considered
R1024	T1475	T1474	arg2Of	considered,is
R1025	T1475	T1476	arg1Of	considered,as
R1026	T1479	T1476	arg2Of	factor,as
R1027	T1479	T1477	arg1Of	factor,a
R1028	T1479	T1478	arg1Of	factor,pro-survival
R1029	T1479	T1480	arg1Of	factor,for
R1030	T1482	T1480	arg2Of	cells,for
R1031	T1482	T1481	arg1Of	cells,cancer
R1032	T1482	T1483	arg1Of	cells,(
R1033	T1484	T1483	arg2Of	Li,(
R1034	T1484	T1485	arg1Of	Li,et
R1035	T1484	T1486	arg1Of	Li,al.
R1036	T1484	T1487	arg1Of	Li,","
R1037	T1488	T1487	arg2Of	2012,","
R1038	T1489	T1483	arg3Of	),(
R1039	T1490	T1491	arg1Of	Integrins,play
R1040	T1491	T1494	arg1Of	play,in
R1041	T1491	T1502	arg1Of	play,and
R1042	T1493	T1491	arg2Of	role,play
R1043	T1493	T1492	arg1Of	role,a
R1044	T1496	T1494	arg2Of	resistance,in
R1045	T1496	T1495	arg1Of	resistance,the
R1046	T1496	T1497	arg1Of	resistance,of
R1047	T1496	T1500	arg1Of	resistance,to
R1048	T1499	T1497	arg2Of	cancers,of
R1049	T1499	T1498	arg1Of	cancers,advanced
R1050	T1501	T1500	arg2Of	radiotherapy,to
R1051	T1502	T1511	arg1Of	and,and
R1052	T1505	T1503	arg1Of	integrin,chemotherapy.
R1053	T1505	T1504	arg1Of	integrin,α5β1
R1054	T1505	T1507	arg1Of	integrin,regulates
R1055	T1507	T1502	arg2Of	regulates,and
R1056	T1507	T1506	arg1Of	regulates,negatively
R1057	T1509	T1507	arg2Of	signaling,regulates
R1058	T1509	T1508	arg1Of	signaling,p53
R1059	T1511	T1510	arg1Of	and,","
R1060	T1513	T1512	arg1Of	event,the
R1061	T1513	T1514	arg1Of	event,induces
R1062	T1514	T1511	arg2Of	induces,and
R1063	T1517	T1514	arg2Of	resistance,induces
R1064	T1517	T1515	arg1Of	resistance,glioma
R1065	T1517	T1516	arg1Of	resistance,cell
R1066	T1517	T1518	arg1Of	resistance,to
R1067	T1519	T1518	arg2Of	TMZ,to
R1068	T1519	T1520	arg1Of	TMZ,(
R1069	T1519	T1529	modOf	TMZ,ri
R1070	T1521	T1520	arg2Of	Janouskova,(
R1071	T1521	T1522	arg1Of	Janouskova,et
R1072	T1521	T1523	arg1Of	Janouskova,al.
R1073	T1521	T1524	arg1Of	Janouskova,","
R1074	T1525	T1524	arg2Of	2012,","
R1075	T1526	T1520	arg3Of	),(
R1076	T1528	T1527	arg1Of	β1 integ,. α5
R1077	T1528	T1529	arg1Of	β1 integ,ri
R1078	T1528	T1530	arg2Of	β1 integ,n is consi
R1079	T1530	T1529	arg2Of	n is consi,ri
R1080	T1530	T1531	arg1Of	n is consi,de
R1081	T1534	T1531	arg2Of	rapeut,de
R1082	T1534	T1532	arg1Of	rapeut,r
R1083	T1534	T1533	arg1Of	rapeut,ed as a the
R1084	T1534	T1535	arg1Of	rapeut,ic
R1085	T1538	T1535	arg2Of	grade ,ic
R1086	T1538	T1536	arg1Of	grade ,target for
R1087	T1538	T1537	arg1Of	grade ,high-
R1088	T1544	T1539	arg1Of	alkylpurine-DNA-N-glycosylase,The
R1089	T1544	T1540	arg1Of	alkylpurine-DNA-N-glycosylase,base
R1090	T1544	T1541	arg1Of	alkylpurine-DNA-N-glycosylase,excision
R1091	T1544	T1542	arg1Of	alkylpurine-DNA-N-glycosylase,repair
R1092	T1544	T1543	arg1Of	alkylpurine-DNA-N-glycosylase,enzyme
R1093	T1544	T1545	arg1Of	alkylpurine-DNA-N-glycosylase,(
R1094	T1544	T1548	arg1Of	alkylpurine-DNA-N-glycosylase,","
R1095	T1544	T1549	arg1Of	alkylpurine-DNA-N-glycosylase,which
R1096	T1544	T1550	arg1Of	alkylpurine-DNA-N-glycosylase,repairs
R1097	T1544	T1559	arg1Of	alkylpurine-DNA-N-glycosylase,participates
R1098	T1546	T1545	arg2Of	APNG,(
R1099	T1547	T1545	arg3Of	),(
R1100	T1554	T1555	arg1Of	N3-methyladenine,and
R1101	T1555	T1550	arg2Of	and,repairs
R1102	T1555	T1551	arg1Of	and,the
R1103	T1555	T1552	arg1Of	and,cytotoxic
R1104	T1555	T1553	arg1Of	and,lesions
R1105	T1556	T1555	arg2Of	N7-methylguanine,and
R1106	T1559	T1557	arg1Of	participates,","
R1107	T1559	T1558	arg1Of	participates,also
R1108	T1559	T1560	arg1Of	participates,in
R1109	T1559	T1564	arg1Of	participates,(
R1110	T1563	T1560	arg2Of	resistance,in
R1111	T1563	T1561	arg1Of	resistance,the
R1112	T1563	T1562	arg1Of	resistance,TMZ
R1113	T1565	T1564	arg2Of	Agnihotri,(
R1114	T1565	T1566	arg1Of	Agnihotri,et
R1115	T1565	T1567	arg1Of	Agnihotri,al.
R1116	T1565	T1568	arg1Of	Agnihotri,","
R1117	T1569	T1568	arg2Of	2012,","
R1118	T1570	T1564	arg3Of	),(
R1119	T1571	T1572	arg1Of	Upregulation,of
R1120	T1571	T1577	modOf	Upregulation,to
R1121	T1571	T1593	arg1Of	Upregulation,contributes
R1122	T1576	T1572	arg2Of	coupling,of
R1123	T1576	T1573	arg1Of	coupling,mitochondrial
R1124	T1576	T1574	arg1Of	coupling,respiratory
R1125	T1576	T1575	arg1Of	coupling,chain
R1126	T1578	T1577	arg1Of	suppress,to
R1127	T1580	T1578	arg2Of	production,suppress
R1128	T1580	T1579	arg1Of	production,the
R1129	T1580	T1581	arg1Of	production,of
R1130	T1584	T1581	arg2Of	species,of
R1131	T1584	T1582	arg1Of	species,reactive
R1132	T1584	T1583	arg1Of	species,oxygen
R1133	T1584	T1585	arg1Of	species,(
R1134	T1584	T1588	arg2Of	species,regulated
R1135	T1586	T1585	arg2Of	ROS,(
R1136	T1587	T1585	arg3Of	),(
R1137	T1592	T1588	arg1Of	oxidase,regulated
R1138	T1592	T1589	arg2Of	oxidase,by
R1139	T1592	T1590	arg1Of	oxidase,cytochrome
R1140	T1592	T1591	arg1Of	oxidase,c
R1141	T1593	T1594	arg1Of	contributes,in
R1142	T1593	T1596	arg1Of	contributes,to
R1143	T1595	T1594	arg2Of	part,in
R1144	T1598	T1596	arg2Of	resistance,to
R1145	T1598	T1597	arg1Of	resistance,TMZ
R1146	T1598	T1599	arg1Of	resistance,in
R1147	T1600	T1599	arg2Of	gliomas,in
R1148	T1600	T1601	arg1Of	gliomas,(
R1149	T1602	T1601	arg2Of	Oliva,(
R1150	T1602	T1603	arg1Of	Oliva,et
R1151	T1602	T1604	arg1Of	Oliva,al.
R1152	T1602	T1605	arg1Of	Oliva,","
R1153	T1606	T1605	arg2Of	2011,","
R1154	T1607	T1601	arg3Of	),(
R1155	T1608	T1609	arg1Of	Reversal,of
R1156	T1608	T1612	arg1Of	Reversal,may
R1157	T1608	T1613	arg1Of	Reversal,be
R1158	T1608	T1614	arg2Of	Reversal,achieved
R1159	T1611	T1609	arg2Of	resistance,of
R1160	T1611	T1610	arg1Of	resistance,TMZ
R1161	T1614	T1612	arg2Of	achieved,may
R1162	T1614	T1613	arg2Of	achieved,be
R1163	T1617	T1614	arg1Of	pseudosubstrates,achieved
R1164	T1617	T1615	arg2Of	pseudosubstrates,by
R1165	T1617	T1616	arg1Of	pseudosubstrates,MGMT
R1166	T1617	T1618	arg1Of	pseudosubstrates,","
R1167	T1619	T1620	arg1Of	O6-benzylguanine,and
R1168	T1620	T1618	arg2Of	and,","
R1169	T1620	T1622	modOf	and,to
R1170	T1621	T1620	arg2Of	lomeguatrib,and
R1171	T1623	T1622	arg1Of	sensitize,to
R1172	T1624	T1623	arg2Of	tumors,sensitize
R1173	T1624	T1625	arg1Of	tumors,to
R1174	T1626	T1625	arg2Of	TMZ,to
R1175	T1626	T1627	arg1Of	TMZ,(
R1176	T1628	T1627	arg2Of	Zhang,(
R1177	T1628	T1629	arg1Of	Zhang,et
R1178	T1628	T1630	arg1Of	Zhang,al.
R1179	T1628	T1631	arg1Of	Zhang,","
R1180	T1632	T1631	arg2Of	2012b,","
R1181	T1633	T1627	arg3Of	),(
R1182	T1634	T1635	arg1Of	Methoxyamine-blocker,of
R1183	T1634	T1639	arg1Of	Methoxyamine-blocker,contributes
R1184	T1638	T1635	arg2Of	repair,of
R1185	T1638	T1636	arg1Of	repair,base
R1186	T1638	T1637	arg1Of	repair,excision
R1187	T1639	T1640	arg1Of	contributes,significantly
R1188	T1639	T1641	arg1Of	contributes,to
R1189	T1639	T1645	arg1Of	contributes,when
R1190	T1643	T1641	arg2Of	cytotoxicity,to
R1191	T1643	T1642	arg1Of	cytotoxicity,TMZ
R1192	T1645	T1644	arg1Of	when,particularly
R1193	T1647	T1646	arg1Of	adducts,O6-methylguanine
R1194	T1647	T1648	arg1Of	adducts,are
R1195	T1647	T1649	arg2Of	adducts,repaired
R1196	T1647	T1651	arg2Of	adducts,tolerated
R1197	T1649	T1650	arg1Of	repaired,or
R1198	T1650	T1645	arg2Of	or,when
R1199	T1650	T1648	arg2Of	or,are
R1200	T1650	T1652	arg1Of	or,(
R1201	T1651	T1650	arg2Of	tolerated,or
R1202	T1653	T1652	arg2Of	Goellner,(
R1203	T1653	T1654	arg1Of	Goellner,et
R1204	T1653	T1655	arg1Of	Goellner,al.
R1205	T1653	T1656	arg1Of	Goellner,","
R1206	T1653	T1658	arg1Of	Goellner,;
R1207	T1657	T1656	arg2Of	2011,","
R1208	T1659	T1658	arg2Of	Zhang,;
R1209	T1659	T1660	arg1Of	Zhang,et
R1210	T1659	T1661	arg1Of	Zhang,al.
R1211	T1659	T1662	arg1Of	Zhang,","
R1212	T1663	T1662	arg2Of	2012b,","
R1213	T1664	T1652	arg3Of	),(
R1214	T1666	T1665	arg1Of	targeting,Dual
R1215	T1666	T1667	arg1Of	targeting,of
R1216	T1670	T1668	arg1Of	repair,base
R1217	T1670	T1669	arg1Of	repair,excision
R1218	T1670	T1671	arg1Of	repair,and
R1219	T1671	T1667	arg2Of	and,of
R1220	T1672	T1671	arg2Of	NAD,and
R1221	T1672	T1673	arg1Of	NAD,(
R1222	T1674	T1673	arg2Of	+,(
R1223	T1675	T1673	arg3Of	),(
R1224	T1676	T1666	arg1Of	biosynthesis,targeting
R1225	T1676	T1677	arg1Of	biosynthesis,may
R1226	T1676	T1678	arg1Of	biosynthesis,reverse
R1227	T1678	T1677	arg2Of	reverse,may
R1228	T1680	T1678	arg2Of	resistance,reverse
R1229	T1680	T1679	arg1Of	resistance,TMZ
R1230	T1680	T1681	arg1Of	resistance,in
R1231	T1680	T1683	arg1Of	resistance,with
R1232	T1682	T1681	arg2Of	patients,in
R1233	T1684	T1685	arg1Of	resistant,and
R1234	T1686	T1685	arg2Of	recurrent,and
R1235	T1687	T1683	arg2Of	GBM,with
R1236	T1687	T1684	arg1Of	GBM,resistant
R1237	T1687	T1686	arg1Of	GBM,recurrent
R1238	T1687	T1688	arg1Of	GBM,(
R1239	T1689	T1688	arg2Of	Goellner,(
R1240	T1689	T1690	arg1Of	Goellner,et
R1241	T1689	T1691	arg1Of	Goellner,al.
R1242	T1689	T1692	arg1Of	Goellner,","
R1243	T1693	T1692	arg2Of	2011,","
R1244	T1694	T1688	arg3Of	),(
R1245	T1695	T1696	arg1Of	Interferon-β,(
R1246	T1695	T1699	arg1Of	Interferon-β,","
R1247	T1697	T1696	arg2Of	IFN-β,(
R1248	T1698	T1696	arg3Of	),(
R1249	T1699	T1704	arg1Of	",",","
R1250	T1700	T1699	arg2Of	levetiracetam,","
R1251	T1700	T1701	arg1Of	levetiracetam,(
R1252	T1702	T1701	arg2Of	LEV,(
R1253	T1703	T1701	arg3Of	),(
R1254	T1704	T1707	arg1Of	",",and
R1255	T1705	T1704	arg2Of	resveratrol,","
R1256	T1707	T1706	arg1Of	and,","
R1257	T1707	T1713	arg1Of	and,increase
R1258	T1709	T1707	arg2Of	acid,and
R1259	T1709	T1708	arg1Of	acid,valproic
R1260	T1709	T1710	arg1Of	acid,(
R1261	T1711	T1710	arg2Of	VAP,(
R1262	T1712	T1710	arg3Of	),(
R1263	T1713	T1718	arg1Of	increase,through
R1264	T1713	T1723	arg1Of	increase,(
R1265	T1715	T1713	arg2Of	sensitivity,increase
R1266	T1715	T1714	arg1Of	sensitivity,the
R1267	T1715	T1716	arg1Of	sensitivity,of
R1268	T1717	T1716	arg2Of	TMZ,of
R1269	T1719	T1720	arg1Of	MGMT-dependent,or
R1270	T1721	T1720	arg2Of	-independent,or
R1271	T1722	T1718	arg2Of	mechanisms,through
R1272	T1722	T1719	arg1Of	mechanisms,MGMT-dependent
R1273	T1722	T1721	arg1Of	mechanisms,-independent
R1274	T1724	T1723	arg2Of	Nakada,(
R1275	T1724	T1725	arg1Of	Nakada,et
R1276	T1724	T1726	arg1Of	Nakada,al.
R1277	T1724	T1727	arg1Of	Nakada,","
R1278	T1728	T1727	arg2Of	2012,","
R1279	T1729	T1723	arg3Of	),(
R1280	T1730	T1731	arg1Of	Resveratrol,","
R1281	T1730	T1736	arg1Of	Resveratrol,reverses
R1282	T1734	T1731	arg2Of	polyphenol,","
R1283	T1734	T1732	arg1Of	polyphenol,a
R1284	T1734	T1733	arg1Of	polyphenol,natural
R1285	T1736	T1735	arg1Of	reverses,","
R1286	T1736	T1739	arg1Of	reverses,via
R1287	T1736	T1743	arg1Of	reverses,(
R1288	T1738	T1736	arg2Of	resistance,reverses
R1289	T1738	T1737	arg1Of	resistance,TMZ
R1290	T1742	T1739	arg2Of	mechanism,via
R1291	T1742	T1740	arg1Of	mechanism,an
R1292	T1742	T1741	arg1Of	mechanism,NF-κB-dependent
R1293	T1744	T1743	arg2Of	Huang,(
R1294	T1744	T1745	arg1Of	Huang,et
R1295	T1744	T1746	arg1Of	Huang,al.
R1296	T1744	T1747	arg1Of	Huang,","
R1297	T1748	T1747	arg2Of	2012,","
R1298	T1749	T1743	arg3Of	),(
R1299	T1751	T1750	arg1Of	inhibitor,STAT3
R1300	T1751	T1752	arg1Of	inhibitor,or
R1301	T1752	T1755	arg1Of	or,potentiates
R1302	T1754	T1752	arg2Of	knockdown,or
R1303	T1754	T1753	arg1Of	knockdown,STAT3
R1304	T1757	T1755	arg2Of	efficacy,potentiates
R1305	T1757	T1756	arg1Of	efficacy,TMZ
R1306	T1757	T1758	arg1Of	efficacy,in
R1307	T1762	T1758	arg2Of	lines,in
R1308	T1785	T1783	arg2Of	resistance,of
R1309	T1785	T1784	arg1Of	resistance,TMZ
R1310	T1787	T1786	arg2Of	hyperoxia,Induced
R1311	T1787	T1788	arg1Of	hyperoxia,can
R1312	T1787	T1789	arg1Of	hyperoxia,be
R1313	T1787	T1790	arg2Of	hyperoxia,utilized
R1314	T1762	T1759	arg1Of	lines,resistant
R1315	T1762	T1760	arg1Of	lines,GBM
R1316	T1790	T1788	arg2Of	utilized,can
R1317	T1790	T1789	arg2Of	utilized,be
R1318	T1762	T1761	arg1Of	lines,cell
R1319	T1762	T1763	arg1Of	lines,(
R1320	T1792	T1790	arg3Of	reverse,utilized
R1321	T1792	T1791	arg1Of	reverse,to
R1322	T1764	T1763	arg2Of	Kohsaka,(
R1323	T1794	T1792	arg2Of	resistance,reverse
R1324	T1794	T1793	arg1Of	resistance,TMZ
R1325	T1794	T1795	arg1Of	resistance,in
R1326	T1796	T1795	arg2Of	GBMs,in
R1327	T1796	T1797	arg1Of	GBMs,(
R1328	T1764	T1765	arg1Of	Kohsaka,et
R1329	T1798	T1797	arg2Of	Sun,(
R1330	T1798	T1799	arg1Of	Sun,et
R1331	T1798	T1800	arg1Of	Sun,al.
R1332	T1798	T1801	arg1Of	Sun,","
R1333	T1764	T1766	arg1Of	Kohsaka,al.
R1334	T1764	T1767	arg1Of	Kohsaka,","
R1335	T1768	T1767	arg2Of	2012,","
R1336	T1802	T1801	arg2Of	2012,","
R1337	T1803	T1797	arg3Of	),(
R1338	T1806	T1804	arg1Of	cells,Cancer
R1339	T1806	T1805	arg1Of	cells,stem
R1340	T1806	T1807	arg1Of	cells,are
R1341	T1807	T1808	arg1Of	are,probably
R1342	T1769	T1763	arg3Of	),(
R1343	T1810	T1807	arg2Of	key,are
R1344	T1810	T1809	arg1Of	key,the
R1345	T1810	T1811	arg1Of	key,to
R1346	T1810	T1813	arg1Of	key,in
R1347	T1771	T1770	arg1Of	hypoxia,Intratumoral
R1348	T1812	T1811	arg2Of	failure,to
R1349	T1815	T1813	arg2Of	treatment,in
R1350	T1815	T1814	arg1Of	treatment,TMZ
R1351	T1817	T1816	arg1Of	concept,The
R1352	T1817	T1818	arg1Of	concept,of
R1353	T1817	T1823	arg1Of	concept,from
R1354	T1817	T1831	arg1Of	concept,has
R1355	T1817	T1832	arg1Of	concept,been
R1356	T1817	T1834	arg2Of	concept,complicated
R1357	T1817	T1837	arg2Of	concept,thought
R1358	T1771	T1772	arg1Of	hypoxia,is
R1359	T1771	T1773	arg1Of	hypoxia,common
R1360	T1771	T1777	arg1Of	hypoxia,may
R1361	T1771	T1778	arg1Of	hypoxia,be
R1362	T1771	T1779	arg2Of	hypoxia,associated
R1363	T1822	T1818	arg2Of	survival,of
R1364	T1822	T1819	arg1Of	survival,cancer
R1365	T1822	T1820	arg1Of	survival,stem
R1366	T1822	T1821	arg1Of	survival,cell
R1367	T1772	T1774	arg1Of	is,in
R1368	T1824	T1823	arg2Of	treatment,from
R1369	T1824	T1825	arg1Of	treatment,with
R1370	T1826	T1827	arg1Of	TMZ,and
R1371	T1772	T1776	arg1Of	is,and
R1372	T1827	T1825	arg2Of	and,with
R1373	T1773	T1772	arg2Of	common,is
R1374	T1830	T1827	arg2Of	drugs,and
R1375	T1830	T1828	arg1Of	drugs,other
R1376	T1830	T1829	arg1Of	drugs,chemotherapeutic
R1377	T1775	T1774	arg2Of	GBMs,in
R1379	T1835	T1831	arg2Of	than,has
R1380	T1835	T1832	arg2Of	than,been
R1381	T1835	T1833	arg1Of	than,more
R1382	T1779	T1776	arg2Of	associated,and
R1383	T1837	T1835	arg2Of	thought,than
R1384	T1837	T1836	arg1Of	thought,previously
R1385	T1837	T1838	arg1Of	thought,(
R1386	T1839	T1838	arg2Of	Beier,(
R1387	T1839	T1840	arg1Of	Beier,et
R1388	T1839	T1841	arg1Of	Beier,al.
R1389	T1839	T1842	arg1Of	Beier,","
R1390	T1839	T1844	arg1Of	Beier,;
R1391	T1843	T1842	arg2Of	2011,","
R1392	T1779	T1777	arg2Of	associated,may
R1393	T1779	T1778	arg2Of	associated,be
R1394	T1845	T1844	arg2Of	Chen,;
R1395	T1779	T1780	arg1Of	associated,with
R1396	T1782	T1780	arg2Of	development,with
R1397	T1845	T1846	arg1Of	Chen,et
R1398	T1845	T1847	arg1Of	Chen,al.
R1399	T1845	T1848	arg1Of	Chen,","
R1400	T1849	T1848	arg2Of	2012,","
R1401	T1850	T1838	arg3Of	),(
R1402	T1782	T1781	arg1Of	development,the
R1403	T1854	T1851	arg1Of	cells,CD133-positive
R1404	T1854	T1852	arg1Of	cells,cancer
R1405	T1854	T1853	arg1Of	cells,stem
R1406	T1854	T1855	arg1Of	cells,are
R1407	T1854	T1856	arg2Of	cells,expressed
R1408	T1856	T1855	arg2Of	expressed,are
R1409	T1856	T1857	arg1Of	expressed,in
R1410	T1856	T1866	arg1Of	expressed,(
R1411	T1782	T1783	arg1Of	development,of
R1412	T1886	T1882	arg2Of	cells,for
R1413	T1861	T1859	arg1Of	cells,normal
R1414	T1861	T1860	arg1Of	cells,stem
R1415	T1861	T1862	arg1Of	cells,and
R1416	T1862	T1857	arg2Of	and,in
R1417	T1862	T1858	arg1Of	and,both
R1418	T1865	T1862	arg2Of	cells,and
R1419	T1865	T1863	arg1Of	cells,cancer
R1420	T1865	T1864	arg1Of	cells,stem
R1421	T1867	T1868	arg1Of	Donovan,and
R1422	T1868	T1866	arg2Of	and,(
R1423	T1868	T1870	arg1Of	and,","
R1424	T1869	T1868	arg2Of	Pilkington,and
R1425	T1871	T1870	arg2Of	2012,","
R1426	T1872	T1866	arg3Of	),(
R1427	T1886	T1883	arg1Of	cells,glioma
R1428	T1886	T1884	arg1Of	cells,cancer
R1429	T1886	T1885	arg1Of	cells,stem
R1430	T1886	T1887	arg1Of	cells,relative
R1431	T1876	T1875	arg1Of	role,the
R1432	T1876	T1877	arg1Of	role,of
R1433	T1876	T1879	arg1Of	role,as
R1434	T1876	T1892	arg1Of	role,has
R1435	T1876	T1895	arg1Of	role,be
R1436	T1876	T1896	arg2Of	role,established
R1437	T1878	T1877	arg2Of	CD133,of
R1438	T1887	T1888	arg1Of	relative,to
R1439	T1891	T1888	arg2Of	function,to
R1440	T1881	T1879	arg2Of	marker,as
R1441	T1881	T1880	arg1Of	marker,a
R1442	T1881	T1882	arg1Of	marker,for
R1443	T1891	T1889	arg1Of	function,its
R1444	T1891	T1890	arg1Of	function,biological
R1445	T1892	T1873	arg1Of	has,However
R1446	T1892	T1874	arg1Of	has,","
R1447	T1892	T1893	arg1Of	has,yet
R1448	T1896	T1892	arg2Of	established,has
R1449	T1896	T1894	arg1Of	established,to
R1453	T1896	T1895	arg2Of	established,be
R464	T915	T910	arg1Of	patients,Glioblastoma
R465	T915	T911	arg1Of	patients,multiforme
R474	T921	T920	arg2Of	Friedman,(
R491	T938	T920	arg3Of	),(
R563	T1012	T1010	arg1Of	therapy,current
R564	T1012	T1011	arg1Of	therapy,standard
R565	T1012	T1013	arg1Of	therapy,for
R566	T1012	T1016	arg1Of	therapy,includes
R568	T1014	T1013	arg2Of	GBM,for
R569	T1016	T1015	arg1Of	includes,mainly
R570	T1019	T1017	arg1Of	surgery,maximum
R571	T1019	T1018	arg1Of	surgery,debulking

2_test

Id	Subject	Object	Predicate	Lexical cue
23459853-10914698-38778478	150-154	10914698	denotes	2000
23459853-19269895-38778479	170-174	19269895	denotes	2009
23459853-22244911-38778480	191-195	22244911	denotes	2012
23459853-10914698-38778481	363-367	10914698	denotes	2000
23459853-19269895-38778482	383-387	19269895	denotes	2009
23459853-22228201-38778483	515-519	22228201	denotes	2012
23459853-10914698-38778484	727-731	10914698	denotes	2000
23459853-20885105-38778485	744-748	20885105	denotes	2010
23459853-22228201-38778486	1016-1020	22228201	denotes	2012
23459853-22594898-38778487	1070-1074	22594898	denotes	2012
23459853-22675172-38778488	1092-1096	22675172	denotes	2012
23459853-22532597-38778489	1114-1118	22532597	denotes	2012
23459853-21406402-38778491	1275-1279	21406402	denotes	2011
23459853-14705733-38778493	1422-1426	14705733	denotes	2003
23459853-20587533-38778494	1589-1593	20587533	denotes	2010
23459853-23383259-38778495	1745-1749	23383259	denotes	2013
23459853-23028632-38778496	1860-1864	23028632	denotes	2012
23459853-16849758-38778497	2102-2106	16849758	denotes	2006
23459853-18757334-38778498	2121-2125	18757334	denotes	2008
23459853-20032445-38778499	2145-2149	20032445	denotes	2009
23459853-15322239-38778501	2371-2375	15322239	denotes	2004
23459853-16766259-38778502	2396-2400	16766259	denotes	2006
23459853-16819506-38778503	2415-2419	16819506	denotes	2007
23459853-16849758-38778504	2545-2549	16849758	denotes	2006
23459853-18757334-38778505	2564-2568	18757334	denotes	2008
23459853-18483356-38778506	2587-2591	18483356	denotes	2008
23459853-22837675-38778507	2825-2829	22837675	denotes	2012
23459853-20633539-38778508	3091-3095	20633539	denotes	2010
23459853-21909994-38778509	3178-3182	21909994	denotes	2012
23459853-22593187-38778510	3401-3405	22593187	denotes	2012
23459853-22156195-38778511	3693-3697	22156195	denotes	2012
23459853-21931801-38778512	3915-3919	21931801	denotes	2011
23459853-21406402-38778514	4252-4256	21406402	denotes	2011
23459853-21406402-38778516	4433-4437	21406402	denotes	2011
23459853-22912934-38778517	4618-4622	22912934	denotes	2012
23459853-22426504-38778518	4732-4736	22426504	denotes	2012
23459853-22532597-38778519	4844-4848	22532597	denotes	2012
23459853-22763762-38778520	5033-5037	22763762	denotes	2012
23459853-21988793-38778521	5271-5275	21988793	denotes	2011
23459853-22854781-38778522	5290-5294	22854781	denotes	2012
23459853-23106300-38778523	5417-5421	23106300	denotes	2012

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T874	3475-3480	http://purl.obolibrary.org/obo/UBERON_0000955	denotes	brain
T873	948-959	http://purl.obolibrary.org/obo/UBERON_0003104	denotes	mesenchymal

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T2017	4921-4932	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T2016	4330-4342	http://purl.obolibrary.org/obo/GO_0009058	denotes	biosynthesis
T2015	4323-4342	http://purl.obolibrary.org/obo/GO_0009435	denotes	NAD(+) biosynthesis
T2014	4027-4036	http://purl.obolibrary.org/obo/GO_0046960	denotes	sensitize
T2013	3830-3850	http://purl.obolibrary.org/obo/GO_0008535	denotes	cytochrome c oxidase
T2012	3830-3850	http://purl.obolibrary.org/obo/GO_0004129	denotes	cytochrome c oxidase
T2011	3539-3550	http://purl.obolibrary.org/obo/GO_0016798	denotes	glycosylase
T2010	4298-4318	http://purl.obolibrary.org/obo/GO_0006284	denotes	base excision repair
T2009	4098-4118	http://purl.obolibrary.org/obo/GO_0006284	denotes	base excision repair
T2008	3493-3513	http://purl.obolibrary.org/obo/GO_0006284	denotes	base excision repair
T2007	2866-2877	http://purl.obolibrary.org/obo/GO_0032259	denotes	methylation
T2006	2728-2739	http://purl.obolibrary.org/obo/GO_0032259	denotes	methylation
T2005	3318-3327	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2004	2622-2631	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2003	2660-2663	http://purl.obolibrary.org/obo/GO_0006298	denotes	MMR
T2002	2457-2460	http://purl.obolibrary.org/obo/GO_0006298	denotes	MMR
T2001	2262-2265	http://purl.obolibrary.org/obo/GO_0006298	denotes	MMR
T2000	2235-2250	http://purl.obolibrary.org/obo/GO_0006298	denotes	mismatch repair
T1999	2221-2250	http://purl.obolibrary.org/obo/GO_0032425	denotes	activation of mismatch repair
T1998	4560-4564	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T1997	3968-3972	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T1996	2892-2896	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T1995	2847-2851	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T1994	2750-2754	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T1993	2441-2445	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T1992	2181-2185	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T1991	2079-2083	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T1990	3129-3141	http://purl.obolibrary.org/obo/GO_0043066	denotes	pro-survival
T1989	1663-1675	http://purl.obolibrary.org/obo/GO_0043066	denotes	pro-survival
T1988	1516-1532	http://purl.obolibrary.org/obo/GO_0048102	denotes	autophagic death
T1987	2347-2352	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T1986	1527-1532	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T1985	1399-1404	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T1984	2342-2352	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T1983	1394-1404	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T1982	3068-3077	http://purl.obolibrary.org/obo/GO_0097194	denotes	apoptosis
T1981	1832-1841	http://purl.obolibrary.org/obo/GO_0097194	denotes	apoptosis
T1980	1704-1713	http://purl.obolibrary.org/obo/GO_0097194	denotes	apoptosis
T1979	1374-1383	http://purl.obolibrary.org/obo/GO_0097194	denotes	apoptosis
T1978	2332-2352	http://purl.obolibrary.org/obo/GO_0006915	denotes	apoptotic cell death
T1977	1832-1841	http://purl.obolibrary.org/obo/GO_0006915	denotes	apoptosis
T1976	1704-1713	http://purl.obolibrary.org/obo/GO_0006915	denotes	apoptosis
T1975	1374-1383	http://purl.obolibrary.org/obo/GO_0006915	denotes	apoptosis
T1974	1964-1973	http://purl.obolibrary.org/obo/GO_0006914	denotes	autophagy
T1973	1650-1659	http://purl.obolibrary.org/obo/GO_0006914	denotes	autophagy
T1972	1351-1360	http://purl.obolibrary.org/obo/GO_0006914	denotes	autophagy
T1971	937-970	http://purl.obolibrary.org/obo/GO_0001837	denotes	epithelial-mesenchymal transition
T1970	937-970	http://purl.obolibrary.org/obo/GO_0060317	denotes	epithelial-mesenchymal transition
T1969	937-970	http://purl.obolibrary.org/obo/GO_0060231	denotes	epithelial-mesenchymal transition
T1968	937-970	http://purl.obolibrary.org/obo/GO_0010717	denotes	epithelial-mesenchymal transition
T1967	914-935	http://purl.obolibrary.org/obo/GO_0016575	denotes	histone deacetylation

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T2033	3830-3850	http://purl.obolibrary.org/obo/GO_0004129	denotes	cytochrome c oxidase
T2032	3830-3840	http://purl.obolibrary.org/obo/GO_0045158	denotes	cytochrome
T2031	3830-3840	http://purl.obolibrary.org/obo/GO_0045157	denotes	cytochrome
T2030	3830-3840	http://purl.obolibrary.org/obo/GO_0045156	denotes	cytochrome
T2029	3830-3842	http://purl.obolibrary.org/obo/GO_0045155	denotes	cytochrome c
T2028	3830-3840	http://purl.obolibrary.org/obo/GO_0045154	denotes	cytochrome
T2027	3830-3840	http://purl.obolibrary.org/obo/GO_0045153	denotes	cytochrome
T2026	3539-3550	http://purl.obolibrary.org/obo/GO_0016798	denotes	glycosylase
T2025	4560-4564	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T2024	3968-3972	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T2023	2892-2896	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T2022	2847-2851	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T2021	2750-2754	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T2020	2441-2445	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T2019	2181-2185	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT
T2018	2079-2083	http://purl.obolibrary.org/obo/GO_0003908	denotes	MGMT

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T2047	3730-3747	http://purl.obolibrary.org/obo/GO_0070469	denotes	respiratory chain
T2046	3716-3747	http://purl.obolibrary.org/obo/GO_0097249	denotes	mitochondrial respiratory chain
T2045	3716-3747	http://purl.obolibrary.org/obo/GO_0005746	denotes	mitochondrial respiratory chain
T2044	868-885	http://purl.obolibrary.org/obo/GO_1990391	denotes	DNA damage repair
T2043	5486-5491	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2042	5386-5391	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2041	5364-5369	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2040	5324-5329	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2039	5052-5057	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2038	3160-3165	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2037	2772-2777	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2036	1721-1726	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2035	893-898	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2034	837-842	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

sentences

Id	Subject	Object	Predicate	Lexical cue
T909	5424-5554	Sentence	denotes	However, the role of CD133 as a marker for glioma cancer stem cells relative to its biological function has yet to be established.
T908	5297-5423	Sentence	denotes	CD133-positive cancer stem cells are expressed in both normal stem cells and cancer stem cells (Donovan and Pilkington, 2012).
T907	5108-5296	Sentence	denotes	The concept of cancer stem cell survival from treatment with TMZ and other chemotherapeutic drugs has been more complicated than previously thought (Beier et al., 2011; Chen et al., 2012).
T906	5040-5107	Sentence	denotes	Cancer stem cells are probably the key to failure in TMZ treatment.
T905	4952-5039	Sentence	denotes	Induced hyperoxia can be utilized to reverse TMZ resistance in GBMs (Sun et al., 2012).
T904	4851-4951	Sentence	denotes	Intratumoral hypoxia is common in GBMs and may be associated with the development of TMZ resistance.
T903	4739-4850	Sentence	denotes	STAT3 inhibitor or STAT3 knockdown potentiates TMZ efficacy in resistant GBM cell lines (Kohsaka et al., 2012).
T902	4625-4738	Sentence	denotes	Resveratrol, a natural polyphenol, reverses TMZ resistance via an NF-κB-dependent mechanism (Huang et al., 2012).
T901	4440-4624	Sentence	denotes	Interferon-β (IFN-β), levetiracetam (LEV), resveratrol, and valproic acid (VAP) increase the sensitivity of TMZ through MGMT-dependent or -independent mechanisms (Nakada et al., 2012).
T900	4280-4439	Sentence	denotes	Dual targeting of base excision repair and NAD(+) biosynthesis may reverse TMZ resistance in patients with resistant and recurrent GBM (Goellner et al., 2011).
T899	4074-4279	Sentence	denotes	Methoxyamine-blocker of base excision repair contributes significantly to TMZ cytotoxicity particularly when O6-methylguanine adducts are repaired or tolerated (Goellner et al., 2011; Zhang et al., 2012b).
T898	3922-4073	Sentence	denotes	Reversal of TMZ resistance may be achieved by MGMT pseudosubstrates, O6-benzylguanine and lomeguatrib to sensitize tumors to TMZ (Zhang et al., 2012b).
T897	3700-3921	Sentence	denotes	Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011).
T896	3489-3699	Sentence	denotes	The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012).
T895	3185-3488	Sentence	denotes	Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors.
T894	3098-3184	Sentence	denotes	MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012).
T893	2951-3097	Sentence	denotes	Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010).
T892	2832-2950	Sentence	denotes	An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival.
T891	2672-2831	Sentence	denotes	Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012).
T890	2594-2671	Sentence	denotes	The initiation of apoptotic signaling fails in the absence of the MMR system.
T889	2422-2593	Sentence	denotes	High expression of MGMT or loss of MMR contributes significantly to TMZ resistance in many clinical cases (Pollack et al., 2006; Hegi et al., 2008; Sarkaria et al., 2008).
T888	2173-2421	Sentence	denotes	Without MGMT repair, O6-methylguanine initiates activation of mismatch repair-deficient (MMR) proteins or Rad3-related protein kinase that ultimately leads to apoptotic cell death (Caporali et al., 2004; Wang and Edelmann, 2006; Roos et al., 2007).
T887	1975-2172	Sentence	denotes	The O6-methylguanine lesion is a substrate for direct repair by O6-methylguanine-DNA methyltransferase (MGMT) (Pollack et al., 2006; Hegi et al., 2008; Fukushima et al., 2009; Zhang et al., 2012b).
T886	1910-1974	Sentence	denotes	It is not determined whether this gene is involved in autophagy.
T885	1867-1909	Sentence	denotes	MAPO2 gene encodes a novel 37-kDa protein.
T884	1752-1866	Sentence	denotes	Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012).
T883	1596-1751	Sentence	denotes	However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013).
T882	1429-1595	Sentence	denotes	Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010).
T881	1303-1428	Sentence	denotes	The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003).
T880	1142-1302	Sentence	denotes	Temozolomide induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b).
T879	751-1141	Sentence	denotes	Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b).
T878	544-750	Sentence	denotes	The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010).
T877	390-543	Sentence	denotes	High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012).
T876	198-389	Sentence	denotes	Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009).
T875	58-197	Sentence	denotes	Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012).
T10	0-57	Sentence	denotes	Mechanisms of Resistance to Temozolomide in Glioblastomas
T11	58-197	Sentence	denotes	Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012).
T12	198-389	Sentence	denotes	Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009).
T13	390-543	Sentence	denotes	High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012).
T14	544-750	Sentence	denotes	The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010).
T15	751-1141	Sentence	denotes	Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b).
T16	1142-1302	Sentence	denotes	Temozolomide induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b).
T17	1303-1428	Sentence	denotes	The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003).
T18	1429-1595	Sentence	denotes	Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010).
T19	1596-1751	Sentence	denotes	However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013).
T20	1752-1866	Sentence	denotes	Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012).
T21	1867-1909	Sentence	denotes	MAPO2 gene encodes a novel 37-kDa protein.
T22	1910-1974	Sentence	denotes	It is not determined whether this gene is involved in autophagy.
T23	1975-2172	Sentence	denotes	The O6-methylguanine lesion is a substrate for direct repair by O6-methylguanine-DNA methyltransferase (MGMT) (Pollack et al., 2006; Hegi et al., 2008; Fukushima et al., 2009; Zhang et al., 2012b).
T24	2173-2421	Sentence	denotes	Without MGMT repair, O6-methylguanine initiates activation of mismatch repair-deficient (MMR) proteins or Rad3-related protein kinase that ultimately leads to apoptotic cell death (Caporali et al., 2004; Wang and Edelmann, 2006; Roos et al., 2007).
T25	2422-2593	Sentence	denotes	High expression of MGMT or loss of MMR contributes significantly to TMZ resistance in many clinical cases (Pollack et al., 2006; Hegi et al., 2008; Sarkaria et al., 2008).
T26	2594-2671	Sentence	denotes	The initiation of apoptotic signaling fails in the absence of the MMR system.
T27	2672-2831	Sentence	denotes	Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012).
T28	2832-2950	Sentence	denotes	An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival.
T29	2951-3097	Sentence	denotes	Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010).
T30	3098-3184	Sentence	denotes	MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012).
T31	3185-3488	Sentence	denotes	Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors.
T32	3489-3699	Sentence	denotes	The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012).
T33	3700-3921	Sentence	denotes	Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011).
T34	3922-4073	Sentence	denotes	Reversal of TMZ resistance may be achieved by MGMT pseudosubstrates, O6-benzylguanine and lomeguatrib to sensitize tumors to TMZ (Zhang et al., 2012b).
T35	4074-4279	Sentence	denotes	Methoxyamine-blocker of base excision repair contributes significantly to TMZ cytotoxicity particularly when O6-methylguanine adducts are repaired or tolerated (Goellner et al., 2011; Zhang et al., 2012b).
T36	4280-4439	Sentence	denotes	Dual targeting of base excision repair and NAD(+) biosynthesis may reverse TMZ resistance in patients with resistant and recurrent GBM (Goellner et al., 2011).
T37	4440-4624	Sentence	denotes	Interferon-β (IFN-β), levetiracetam (LEV), resveratrol, and valproic acid (VAP) increase the sensitivity of TMZ through MGMT-dependent or -independent mechanisms (Nakada et al., 2012).
T38	4625-4738	Sentence	denotes	Resveratrol, a natural polyphenol, reverses TMZ resistance via an NF-κB-dependent mechanism (Huang et al., 2012).
T39	4739-4850	Sentence	denotes	STAT3 inhibitor or STAT3 knockdown potentiates TMZ efficacy in resistant GBM cell lines (Kohsaka et al., 2012).
T40	4851-4951	Sentence	denotes	Intratumoral hypoxia is common in GBMs and may be associated with the development of TMZ resistance.
T41	4952-5039	Sentence	denotes	Induced hyperoxia can be utilized to reverse TMZ resistance in GBMs (Sun et al., 2012).
T42	5040-5107	Sentence	denotes	Cancer stem cells are probably the key to failure in TMZ treatment.
T43	5108-5296	Sentence	denotes	The concept of cancer stem cell survival from treatment with TMZ and other chemotherapeutic drugs has been more complicated than previously thought (Beier et al., 2011; Chen et al., 2012).
T44	5297-5423	Sentence	denotes	CD133-positive cancer stem cells are expressed in both normal stem cells and cancer stem cells (Donovan and Pilkington, 2012).
T45	5424-5554	Sentence	denotes	However, the role of CD133 as a marker for glioma cancer stem cells relative to its biological function has yet to be established.

simple1

Id	Subject	Object	Predicate	Lexical cue
T2073	5445-5450	Protein	denotes	CD133
T2072	5297-5302	Protein	denotes	CD133
T2071	4758-4763	Protein	denotes	STAT3
T2070	4739-4744	Protein	denotes	STAT3
T2069	4560-4564	Protein	denotes	MGMT
T2068	4454-4459	Protein	denotes	IFN-β
T2067	4440-4452	Protein	denotes	Interferon-β
T2066	3968-3972	Protein	denotes	MGMT
T2065	3314-3317	Protein	denotes	p53
T2064	3098-3109	Protein	denotes	MicroRNA-21
T2063	3019-3028	Protein	denotes	caspase-3
T2062	3003-3008	Protein	denotes	Bcl-2
T2061	2999-3002	Protein	denotes	Bax
T2060	2979-2990	Protein	denotes	microRNA-21
T2059	2892-2896	Protein	denotes	MGMT
T2058	2847-2851	Protein	denotes	MGMT
T2057	2750-2754	Protein	denotes	MGMT
T2056	2441-2445	Protein	denotes	MGMT
T2055	2181-2185	Protein	denotes	MGMT
T2054	2079-2083	Protein	denotes	MGMT
T2053	2039-2077	Protein	denotes	O6-methylguanine-DNA methyltransferase
T2052	1867-1872	Protein	denotes	MAPO2
T2051	1765-1773	Protein	denotes	C1orf201
T2050	1758-1763	Protein	denotes	MAPO2
T2049	1478-1483	Protein	denotes	Bcl-2
T2048	1463-1468	Protein	denotes	Bcl-2

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