PMC:3586680 / 10475-11095 JSONTXT

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    test3

    Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009).

    testone

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    bionlp-st-ge-2016-test-tees

    {"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T5454","span":{"begin":402,"end":411},"obj":"Protein"},{"id":"T5453","span":{"begin":398,"end":401},"obj":"Protein"},{"id":"T5452","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T5451","span":{"begin":261,"end":271},"obj":"Positive_regulation"},{"id":"T5450","span":{"begin":199,"end":208},"obj":"Binding"},{"id":"T5449","span":{"begin":272,"end":275},"obj":"Protein"},{"id":"T5448","span":{"begin":173,"end":187},"obj":"Protein"},{"id":"T5447","span":{"begin":77,"end":82},"obj":"Binding"},{"id":"T5446","span":{"begin":25,"end":29},"obj":"Protein"},{"id":"T5458","span":{"begin":566,"end":569},"obj":"Protein"},{"id":"T5457","span":{"begin":493,"end":514},"obj":"Protein"},{"id":"T5456","span":{"begin":462,"end":465},"obj":"Protein"},{"id":"T5455","span":{"begin":337,"end":342},"obj":"Binding"}],"relations":[{"id":"R3780","pred":"themeOf","subj":"T5446","obj":"T5447"},{"id":"R3782","pred":"themeOf","subj":"T5448","obj":"T5450"},{"id":"R3783","pred":"themeOf","subj":"T5449","obj":"T5451"},{"id":"R3785","pred":"themeOf","subj":"T5452","obj":"T5455"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    bionlp-st-ge-2016-spacy-parsed

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stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    bionlp-st-ge-2016-test-ihmc

    {"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T5770","span":{"begin":173,"end":187},"obj":"Positive_regulation"},{"id":"T5765","span":{"begin":173,"end":254},"obj":"Binding"},{"id":"T5762","span":{"begin":332,"end":369},"obj":"Binding"},{"id":"T5756","span":{"begin":479,"end":497},"obj":"Positive_regulation"},{"id":"T5755","span":{"begin":479,"end":497},"obj":"Gene_expression"},{"id":"T5752","span":{"begin":209,"end":254},"obj":"Phosphorylation"},{"id":"T5751","span":{"begin":479,"end":565},"obj":"Regulation"},{"id":"T5748","span":{"begin":25,"end":108},"obj":"Binding"},{"id":"T5742","span":{"begin":25,"end":29},"obj":"Protein"},{"id":"T5732","span":{"begin":518,"end":531},"obj":"Entity"},{"id":"T5720","span":{"begin":83,"end":91},"obj":"Protein"},{"id":"T5713","span":{"begin":343,"end":369},"obj":"Protein"},{"id":"T5710","span":{"begin":398,"end":440},"obj":"Protein"},{"id":"T5701","span":{"begin":209,"end":254},"obj":"Protein"},{"id":"T5638","span":{"begin":509,"end":514},"obj":"Protein"},{"id":"T5633","span":{"begin":402,"end":411},"obj":"Protein"},{"id":"T5629","span":{"begin":462,"end":465},"obj":"Protein"},{"id":"T5625","span":{"begin":364,"end":367},"obj":"Protein"},{"id":"T5623","span":{"begin":66,"end":72},"obj":"Entity"},{"id":"T5622","span":{"begin":173,"end":187},"obj":"Protein"},{"id":"T5614","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T5672","span":{"begin":214,"end":238},"obj":"Entity"},{"id":"T5666","span":{"begin":272,"end":275},"obj":"Protein"},{"id":"T5663","span":{"begin":479,"end":497},"obj":"Protein"},{"id":"T5661","span":{"begin":551,"end":565},"obj":"Protein"}],"relations":[{"id":"R3832","pred":"themeOf","subj":"T5614","obj":"T5762"},{"id":"R3834","pred":"themeOf","subj":"T5622","obj":"T5770"},{"id":"R3855","pred":"causeOf","subj":"T5661","obj":"T5751"},{"id":"R3858","pred":"themeOf","subj":"T5663","obj":"T5751"},{"id":"R3859","pred":"themeOf","subj":"T5663","obj":"T5755"},{"id":"R3860","pred":"themeOf","subj":"T5663","obj":"T5756"},{"id":"R3863","pred":"partOf","subj":"T5672","obj":"T5701"},{"id":"R3864","pred":"siteOf","subj":"T5672","obj":"T5752"},{"id":"R3883","pred":"themeOf","subj":"T5701","obj":"T5752"},{"id":"R3884","pred":"themeOf","subj":"T5701","obj":"T5765"},{"id":"R3887","pred":"themeOf","subj":"T5713","obj":"T5762"},{"id":"R3888","pred":"themeOf","subj":"T5742","obj":"T5748"},{"id":"R3891","pred":"themeOf","subj":"T5720","obj":"T5748"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    DLUT931

    {"project":"DLUT931","denotations":[{"id":"T5238","span":{"begin":498,"end":508},"obj":"Binding"},{"id":"T5237","span":{"begin":479,"end":492},"obj":"Positive_regulation"},{"id":"T5236","span":{"begin":337,"end":342},"obj":"Binding"},{"id":"T5235","span":{"begin":261,"end":271},"obj":"Negative_regulation"},{"id":"T5234","span":{"begin":221,"end":238},"obj":"Phosphorylation"},{"id":"T5233","span":{"begin":199,"end":208},"obj":"Binding"},{"id":"T5232","span":{"begin":173,"end":182},"obj":"Positive_regulation"},{"id":"T5231","span":{"begin":77,"end":82},"obj":"Binding"},{"id":"T5230","span":{"begin":33,"end":42},"obj":"Positive_regulation"},{"id":"T5202","span":{"begin":551,"end":556},"obj":"Protein"},{"id":"T5201","span":{"begin":509,"end":514},"obj":"Protein"},{"id":"T5200","span":{"begin":493,"end":497},"obj":"Protein"},{"id":"T5199","span":{"begin":402,"end":411},"obj":"Protein"},{"id":"T5198","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T5197","span":{"begin":272,"end":275},"obj":"Protein"},{"id":"T5196","span":{"begin":239,"end":242},"obj":"Protein"},{"id":"T5195","span":{"begin":183,"end":187},"obj":"Protein"},{"id":"T5194","span":{"begin":25,"end":29},"obj":"Protein"}],"relations":[{"id":"R3649","pred":"themeOf","subj":"T5194","obj":"T5230"},{"id":"R3650","pred":"themeOf","subj":"T5194","obj":"T5231"},{"id":"R3651","pred":"themeOf","subj":"T5195","obj":"T5232"},{"id":"R3652","pred":"themeOf","subj":"T5195","obj":"T5233"},{"id":"R3653","pred":"themeOf","subj":"T5196","obj":"T5233"},{"id":"R3654","pred":"themeOf","subj":"T5196","obj":"T5234"},{"id":"R3655","pred":"causeOf","subj":"T5196","obj":"T5235"},{"id":"R3656","pred":"themeOf","subj":"T5197","obj":"T5235"},{"id":"R3657","pred":"themeOf","subj":"T5198","obj":"T5236"},{"id":"R3658","pred":"themeOf","subj":"T5200","obj":"T5237"},{"id":"R3659","pred":"themeOf","subj":"T5200","obj":"T5238"},{"id":"R3660","pred":"themeOf","subj":"T5201","obj":"T5238"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    BioNLP16_Messiy

    {"project":"BioNLP16_Messiy","denotations":[{"id":"T5392","span":{"begin":498,"end":508},"obj":"Negative_regulation"},{"id":"T5391","span":{"begin":479,"end":492},"obj":"Positive_regulation"},{"id":"T5390","span":{"begin":337,"end":342},"obj":"Binding"},{"id":"T5389","span":{"begin":199,"end":208},"obj":"Binding"},{"id":"T5388","span":{"begin":173,"end":182},"obj":"Positive_regulation"},{"id":"T5387","span":{"begin":221,"end":238},"obj":"Phosphorylation"},{"id":"T5386","span":{"begin":261,"end":271},"obj":"Negative_regulation"},{"id":"T5385","span":{"begin":77,"end":82},"obj":"Binding"},{"id":"T5384","span":{"begin":33,"end":42},"obj":"Positive_regulation"},{"id":"T5353","span":{"begin":551,"end":556},"obj":"Protein"},{"id":"T5352","span":{"begin":509,"end":514},"obj":"Protein"},{"id":"T5351","span":{"begin":493,"end":497},"obj":"Protein"},{"id":"T5350","span":{"begin":402,"end":411},"obj":"Protein"},{"id":"T5349","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T5348","span":{"begin":272,"end":275},"obj":"Protein"},{"id":"T5347","span":{"begin":239,"end":242},"obj":"Protein"},{"id":"T5346","span":{"begin":183,"end":187},"obj":"Protein"},{"id":"T5345","span":{"begin":25,"end":29},"obj":"Protein"}],"relations":[{"id":"R3700","pred":"causeOf","subj":"T5389","obj":"T5386"},{"id":"R3727","pred":"themeOf","subj":"T5345","obj":"T5385"},{"id":"R3728","pred":"themeOf","subj":"T5345","obj":"T5384"},{"id":"R3729","pred":"themeOf","subj":"T5346","obj":"T5388"},{"id":"R3730","pred":"themeOf","subj":"T5346","obj":"T5389"},{"id":"R3731","pred":"themeOf","subj":"T5347","obj":"T5389"},{"id":"R3732","pred":"themeOf","subj":"T5347","obj":"T5387"},{"id":"R3734","pred":"themeOf","subj":"T5348","obj":"T5386"},{"id":"R3736","pred":"themeOf","subj":"T5349","obj":"T5390"},{"id":"R3737","pred":"themeOf","subj":"T5351","obj":"T5391"},{"id":"R3738","pred":"themeOf","subj":"T5352","obj":"T5392"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    BioNLP16_DUT

    {"project":"BioNLP16_DUT","denotations":[{"id":"T5119","span":{"begin":479,"end":492},"obj":"Gene_expression"},{"id":"T5118","span":{"begin":498,"end":508},"obj":"Binding"},{"id":"T5117","span":{"begin":479,"end":492},"obj":"Positive_regulation"},{"id":"T5116","span":{"begin":337,"end":342},"obj":"Binding"},{"id":"T5115","span":{"begin":199,"end":208},"obj":"Binding"},{"id":"T5114","span":{"begin":221,"end":238},"obj":"Phosphorylation"},{"id":"T5113","span":{"begin":173,"end":182},"obj":"Positive_regulation"},{"id":"T5112","span":{"begin":261,"end":271},"obj":"Positive_regulation"},{"id":"T5111","span":{"begin":33,"end":42},"obj":"Positive_regulation"},{"id":"T5110","span":{"begin":77,"end":82},"obj":"Binding"},{"id":"T5080","span":{"begin":551,"end":556},"obj":"Protein"},{"id":"T5079","span":{"begin":509,"end":514},"obj":"Protein"},{"id":"T5078","span":{"begin":493,"end":497},"obj":"Protein"},{"id":"T5077","span":{"begin":402,"end":411},"obj":"Protein"},{"id":"T5076","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T5075","span":{"begin":272,"end":275},"obj":"Protein"},{"id":"T5074","span":{"begin":239,"end":242},"obj":"Protein"},{"id":"T5073","span":{"begin":183,"end":187},"obj":"Protein"},{"id":"T5072","span":{"begin":25,"end":29},"obj":"Protein"}],"relations":[{"id":"R3594","pred":"themeOf","subj":"T5072","obj":"T5110"},{"id":"R3595","pred":"themeOf","subj":"T5072","obj":"T5111"},{"id":"R3596","pred":"themeOf","subj":"T5073","obj":"T5113"},{"id":"R3597","pred":"themeOf","subj":"T5073","obj":"T5115"},{"id":"R3598","pred":"themeOf","subj":"T5074","obj":"T5115"},{"id":"R3599","pred":"themeOf","subj":"T5074","obj":"T5114"},{"id":"R3600","pred":"themeOf","subj":"T5075","obj":"T5112"},{"id":"R3601","pred":"themeOf","subj":"T5076","obj":"T5116"},{"id":"R3602","pred":"themeOf","subj":"T5078","obj":"T5119"},{"id":"R3605","pred":"themeOf","subj":"T5079","obj":"T5119"},{"id":"R3607","pred":"themeOf","subj":"T5079","obj":"T5118"},{"id":"R3631","pred":"themeOf","subj":"T5119","obj":"T5117"},{"id":"R3632","pred":"themeOf","subj":"T5119","obj":"T5117"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    bionlp-st-ge-2016-uniprot

    {"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T5166","span":{"begin":402,"end":411},"obj":"http://www.uniprot.org/uniprot/P35222"},{"id":"T5136","span":{"begin":272,"end":275},"obj":"http://www.uniprot.org/uniprot/P04637"},{"id":"T5135","span":{"begin":239,"end":242},"obj":"http://www.uniprot.org/uniprot/P04637"},{"id":"T5151","span":{"begin":493,"end":497},"obj":"http://www.uniprot.org/uniprot/Q9NZC7"},{"id":"T5150","span":{"begin":332,"end":336},"obj":"http://www.uniprot.org/uniprot/Q9NZC7"},{"id":"T5149","span":{"begin":183,"end":187},"obj":"http://www.uniprot.org/uniprot/Q9NZC7"},{"id":"T5148","span":{"begin":25,"end":29},"obj":"http://www.uniprot.org/uniprot/Q9NZC7"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    bionlp-st-ge-2016-test-proteins

    {"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T4003","span":{"begin":551,"end":556},"obj":"Protein"},{"id":"T4002","span":{"begin":509,"end":514},"obj":"Protein"},{"id":"T4001","span":{"begin":493,"end":497},"obj":"Protein"},{"id":"T4000","span":{"begin":402,"end":411},"obj":"Protein"},{"id":"T3999","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T3998","span":{"begin":272,"end":275},"obj":"Protein"},{"id":"T3997","span":{"begin":239,"end":242},"obj":"Protein"},{"id":"T3996","span":{"begin":183,"end":187},"obj":"Protein"},{"id":"T3995","span":{"begin":25,"end":29},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    bionlp-st-ge-2016-coref

    {"project":"bionlp-st-ge-2016-coref","denotations":[{"id":"T3968","span":{"begin":199,"end":208},"obj":"Antecedent"},{"id":"T3967","span":{"begin":255,"end":260},"obj":"Anaphor"}],"relations":[{"id":"R2747","pred":"boundBy","subj":"T3967","obj":"T3968"}],"namespaces":[{"prefix":"_base","uri":"https://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    pmc-enju-pas

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stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    2_test

    {"project":"2_test","denotations":[{"id":"23459853-11058590-38778551","span":{"begin":139,"end":143},"obj":"11058590"},{"id":"23459853-14555208-38778552","span":{"begin":145,"end":149},"obj":"14555208"},{"id":"23459853-17142102-38778554","span":{"begin":160,"end":164},"obj":"17142102"},{"id":"23459853-20542955-38778555","span":{"begin":166,"end":170},"obj":"20542955"},{"id":"23459853-19465938-38778557","span":{"begin":614,"end":618},"obj":"19465938"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    GO-BP

    {"project":"GO-BP","denotations":[{"id":"T4044","span":{"begin":570,"end":585},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T4052","span":{"begin":498,"end":508},"obj":"http://purl.obolibrary.org/obo/GO_0051235"},{"id":"T4051","span":{"begin":412,"end":429},"obj":"http://purl.obolibrary.org/obo/GO_0007165"},{"id":"T4049","span":{"begin":412,"end":421},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T4046","span":{"begin":47,"end":62},"obj":"http://purl.obolibrary.org/obo/GO_0016310"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    GO-CC

    {"project":"GO-CC","denotations":[{"id":"T4083","span":{"begin":522,"end":531},"obj":"http://purl.obolibrary.org/obo/GO_0005737"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    sentences

    {"project":"sentences","denotations":[{"id":"T3837","span":{"begin":442,"end":620},"obj":"Sentence"},{"id":"T3836","span":{"begin":326,"end":441},"obj":"Sentence"},{"id":"T3835","span":{"begin":173,"end":325},"obj":"Sentence"},{"id":"T3834","span":{"begin":0,"end":172},"obj":"Sentence"},{"id":"T74","span":{"begin":0,"end":172},"obj":"Sentence"},{"id":"T75","span":{"begin":173,"end":325},"obj":"Sentence"},{"id":"T76","span":{"begin":326,"end":441},"obj":"Sentence"},{"id":"T77","span":{"begin":442,"end":466},"obj":"Sentence"},{"id":"T78","span":{"begin":467,"end":620},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}

    simple1

    {"project":"simple1","denotations":[{"id":"T4126","span":{"begin":551,"end":556},"obj":"Protein"},{"id":"T4125","span":{"begin":509,"end":514},"obj":"Protein"},{"id":"T4124","span":{"begin":493,"end":497},"obj":"Protein"},{"id":"T4123","span":{"begin":402,"end":411},"obj":"Protein"},{"id":"T4122","span":{"begin":332,"end":336},"obj":"Protein"},{"id":"T4121","span":{"begin":272,"end":275},"obj":"Protein"},{"id":"T4120","span":{"begin":239,"end":242},"obj":"Protein"},{"id":"T4119","span":{"begin":183,"end":187},"obj":"Protein"},{"id":"T4118","span":{"begin":25,"end":29},"obj":"Protein"}],"text":"Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010). Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b). Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1). No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009)."}