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test3

Id Subject Object Predicate Lexical cue
T41 17-21 Protein denotes WWOX
T42 26-29 Protein denotes p53
T59 17-21 Protein denotes WWOX
T60 26-29 Protein denotes p53
T14063 14483-14487 Protein denotes WWOX
T14062 14437-14441 Protein denotes WWOX
T14061 14420-14423 Protein denotes p53
T14060 14296-14299 Protein denotes p53
T14059 14256-14260 Protein denotes WWOX
T14058 14227-14230 Protein denotes p53
T14057 14151-14155 Protein denotes WWOX
T14056 14104-14107 Protein denotes p53
T14055 14095-14099 Protein denotes WWOX
T14054 14031-14034 Protein denotes p53
T14053 13924-13931 Entity denotes nuclear
T14052 13842-13854 Entity denotes -rich domain
T14051 13772-13775 Protein denotes p53
T14050 13728-13732 Protein denotes WWOX
T14049 13720-13723 Protein denotes p53
T14048 14664-14667 Protein denotes p53
T14047 14612-14616 Protein denotes WWOX
T14046 14565-14568 Protein denotes p53
T14045 14554-14558 Protein denotes WWOX
T14044 14515-14518 Protein denotes p53
T14043 14483-14487 Protein denotes WWOX
T14042 14437-14441 Protein denotes WWOX
T14041 14420-14423 Protein denotes p53
T14040 14296-14299 Protein denotes p53
T14039 14256-14260 Protein denotes WWOX
T14038 14227-14230 Protein denotes p53
T14037 14151-14155 Protein denotes WWOX
T14036 14104-14107 Protein denotes p53
T14035 14095-14099 Protein denotes WWOX
T14034 14031-14034 Protein denotes p53
T14033 13772-13775 Protein denotes p53
T14032 13728-13732 Protein denotes WWOX
T14031 13720-13723 Protein denotes p53
T14070 14759-14766 Entity denotes nuclear
T14069 14664-14667 Protein denotes p53
T14068 14612-14616 Protein denotes WWOX
T14067 14565-14568 Protein denotes p53
T14066 14554-14558 Protein denotes WWOX
T14065 14519-14529 Gene_expression denotes expressing
T14064 14515-14518 Protein denotes p53
T12770 9118-9144 Protein denotes hyaluronoglucosaminidase 2
T12769 9110-9116 Protein denotes Hyal-2
T12768 9073-9108 Protein denotes activated Cdc42-associated kinase 1
T12767 9067-9071 Protein denotes Ack1
T12766 9010-9017 Entity denotes nucleus
T12765 8952-8958 Protein denotes Hyal-2
T12764 8946-8951 Binding denotes binds
T12763 8941-8945 Protein denotes WWOX
T12762 8933-8939 Protein denotes TGF-β1
T12761 8910-8916 Protein denotes TGF-β1
T12760 8872-8878 Protein denotes Hyal-2
T12759 8865-8870 Protein denotes Ezrin
T12758 8857-8864 Phosphorylation denotes phospho
T12757 8846-8852 Protein denotes Hyal-2
T12756 8829-8840 Binding denotes association
T12755 8795-8804 Binding denotes recruited
T12754 8787-8791 Protein denotes WWOX
T12753 8725-8729 Protein denotes WWOX
T12752 8620-8626 Localization denotes import
T12751 8612-8619 Entity denotes nuclear
T12750 8597-8607 Negative_regulation denotes inhibiting
T12749 8581-8588 Binding denotes binding
T12748 8524-8528 Protein denotes WWOX
T12747 8500-8503 Protein denotes Tau
T12746 8489-8493 Protein denotes WWOX
T12745 8407-8414 Binding denotes binding
T12744 8367-8372 Protein denotes ERBB4
T12743 8356-8361 Protein denotes c-Jun
T12742 8349-8354 Protein denotes RUNX2
T12741 8290-8295 Binding denotes binds
T12740 8280-8284 Protein denotes WWOX
T12739 8251-8258 Entity denotes nucleus
T12738 8188-8191 Protein denotes p53
T12737 8182-8187 Binding denotes binds
T12736 8154-8168 Phosphorylation denotes phosphorylated
T12735 8146-8150 Protein denotes WWOX
T12734 7706-7713 Entity denotes nuclear
T12733 7575-7579 Protein denotes WWOX
T12732 7533-7537 Protein denotes WWOX
T12731 9118-9144 Protein denotes hyaluronoglucosaminidase 2
T12730 9110-9116 Protein denotes Hyal-2
T12729 9073-9108 Protein denotes activated Cdc42-associated kinase 1
T12728 9067-9071 Protein denotes Ack1
T12727 8952-8958 Protein denotes Hyal-2
T12726 8941-8945 Protein denotes WWOX
T12725 8933-8939 Protein denotes TGF-β1
T12724 8910-8916 Protein denotes TGF-β1
T12723 8872-8878 Protein denotes Hyal-2
T12722 8865-8870 Protein denotes Ezrin
T12721 8846-8852 Protein denotes Hyal-2
T12464 22781-22785 Protein denotes WWOX
T12463 22773-22776 Protein denotes p53
T12462 22781-22785 Protein denotes WWOX
T12461 22773-22776 Protein denotes p53
T12720 8787-8791 Protein denotes WWOX
T12719 8725-8729 Protein denotes WWOX
T12718 8524-8528 Protein denotes WWOX
T12717 8500-8503 Protein denotes Tau
T12716 8489-8493 Protein denotes WWOX
T12715 8367-8372 Protein denotes ERBB4
T12714 8356-8361 Protein denotes c-Jun
T12713 8349-8354 Protein denotes RUNX2
T12712 8280-8284 Protein denotes WWOX
T12711 8188-8191 Protein denotes p53
T12710 8146-8150 Protein denotes WWOX
T12709 7575-7579 Protein denotes WWOX
T12708 7533-7537 Protein denotes WWOX
T9733 22590-22594 Protein denotes WWOX
T9732 22499-22503 Protein denotes WWOX
T9731 22424-22428 Protein denotes WWOX
T9730 22416-22419 Protein denotes p53
T9729 22181-22185 Protein denotes WWOX
T9728 22021-22031 Gene_expression denotes production
T9727 21988-21992 Protein denotes Wwox
T9726 21823-21827 Protein denotes Wwox
T9725 21622-21626 Protein denotes Wwox
T9724 21463-21467 Protein denotes WWOX
T9723 21402-21406 Protein denotes WWOX
T9722 21367-21371 Protein denotes WWOX
T9721 21300-21304 Protein denotes WWOX
T9720 21266-21270 Protein denotes WWOX
T9719 21224-21228 Protein denotes WWOX
T9718 21168-21172 Protein denotes WWOX
T9717 21119-21123 Protein denotes WWOX
T9716 21067-21071 Protein denotes WWOX
T9715 20876-20880 Protein denotes Wwox
T9714 20586-20590 Protein denotes WWOX
T9713 20577-20580 Protein denotes p53
T9712 20533-20538 Protein denotes TIAF1
T9711 20519-20529 Gene_expression denotes expression
T9710 20396-20400 Protein denotes WWOX
T9709 20325-20335 Gene_expression denotes expression
T9708 20320-20324 Protein denotes WWOX
T9707 20312-20316 Negative_regulation denotes lack
T9706 20050-20054 Protein denotes CD44
T9705 19903-19907 Protein denotes mTOR
T9704 19898-19901 Protein denotes Akt
T9703 19706-19709 Protein denotes p53
T9702 19657-19661 Protein denotes WWOX
T9701 19321-19325 Protein denotes PTEN
T9700 19314-19319 Protein denotes Smad4
T9699 19308-19312 Protein denotes WWOX
T9698 19303-19306 Protein denotes p53
T9697 19126-19129 Protein denotes p53
T9696 19117-19121 Protein denotes WWOX
T9695 19023-19026 Protein denotes p53
T9694 18860-18864 Protein denotes WWOX
T9693 18845-18854 Binding denotes interacts
T9692 18828-18831 Protein denotes p53
T9691 18756-18759 Protein denotes p53
T9690 18692-18696 Protein denotes WWOX
T9689 18631-18635 Protein denotes WWOX
T9688 18251-18261 Negative_regulation denotes inhibition
T9687 17848-17853 Binding denotes binds
T9686 17843-17847 Protein denotes WWOX
T9685 17774-17777 Protein denotes p53
T9684 17762-17766 Protein denotes WWOX
T9683 17741-17748 Binding denotes Binding
T9682 17685-17689 Protein denotes WWOX
T9681 22590-22594 Protein denotes WWOX
T9680 22499-22503 Protein denotes WWOX
T9679 22424-22428 Protein denotes WWOX
T9678 22416-22419 Protein denotes p53
T9677 22181-22185 Protein denotes WWOX
T9676 21988-21992 Protein denotes Wwox
T9675 21823-21827 Protein denotes Wwox
T9674 21622-21626 Protein denotes Wwox
T9673 21463-21467 Protein denotes WWOX
T9672 21402-21406 Protein denotes WWOX
T9671 21367-21371 Protein denotes WWOX
T9670 21300-21304 Protein denotes WWOX
T9669 21266-21270 Protein denotes WWOX
T9668 21224-21228 Protein denotes WWOX
T9667 21168-21172 Protein denotes WWOX
T9666 21119-21123 Protein denotes WWOX
T9665 21067-21071 Protein denotes WWOX
T9664 20876-20880 Protein denotes Wwox
T9663 20586-20590 Protein denotes WWOX
T9662 20577-20580 Protein denotes p53
T9661 20533-20538 Protein denotes TIAF1
T9660 20396-20400 Protein denotes WWOX
T9659 20320-20324 Protein denotes WWOX
T9658 20050-20054 Protein denotes CD44
T9657 19903-19907 Protein denotes mTOR
T9656 19898-19901 Protein denotes Akt
T9655 19706-19709 Protein denotes p53
T9654 19657-19661 Protein denotes WWOX
T9653 19321-19325 Protein denotes PTEN
T9652 19314-19319 Protein denotes Smad4
T9651 19308-19312 Protein denotes WWOX
T9650 19303-19306 Protein denotes p53
T9649 19126-19129 Protein denotes p53
T9648 19117-19121 Protein denotes WWOX
T9647 19023-19026 Protein denotes p53
T9646 18860-18864 Protein denotes WWOX
T9645 18828-18831 Protein denotes p53
T9644 18756-18759 Protein denotes p53
T9643 18692-18696 Protein denotes WWOX
T9642 18631-18635 Protein denotes WWOX
T9641 17843-17847 Protein denotes WWOX
T9640 17774-17777 Protein denotes p53
T9639 17762-17766 Protein denotes WWOX
T9638 17685-17689 Protein denotes WWOX
T8396 17608-17611 Protein denotes p53
T8395 17568-17572 Protein denotes WWOX
T8394 17526-17530 Protein denotes WWOX
T8393 17503-17507 Protein denotes WWOX
T8392 17470-17473 Protein denotes p53
T8391 17334-17338 Protein denotes WWOX
T8390 17318-17321 Protein denotes p53
T8389 17240-17244 Protein denotes WWOX
T8388 17211-17218 Binding denotes binding
T8387 17203-17209 Protein denotes Δ40p53
T8386 17081-17096 Phosphorylation denotes phosphorylation
T8385 17066-17069 Protein denotes p53
T8384 17045-17049 Protein denotes WWOX
T8383 17029-17033 Protein denotes WWOX
T8382 17013-17016 Protein denotes p53
T8381 16784-16793 Protein denotes caspase-3
T8380 16709-16713 Protein denotes WWOX
T8379 16692-16695 Protein denotes p53
T8378 16671-16681 Gene_expression denotes expressing
T8377 16640-16644 Protein denotes WWOX
T8376 16552-16555 Protein denotes p53
T8375 16482-16486 Protein denotes WWOX
T8374 16343-16347 Protein denotes WWOX
T8373 16287-16297 Gene_expression denotes expression
T8372 16282-16286 Protein denotes WWOX
T8371 16205-16208 Protein denotes p53
T8370 16149-16152 Protein denotes p53
T8369 16083-16086 Protein denotes p53
T8368 15852-15855 Protein denotes p53
T8367 17608-17611 Protein denotes p53
T8366 17568-17572 Protein denotes WWOX
T8365 17526-17530 Protein denotes WWOX
T8364 17503-17507 Protein denotes WWOX
T8363 17470-17473 Protein denotes p53
T8362 17334-17338 Protein denotes WWOX
T8361 17318-17321 Protein denotes p53
T8360 17240-17244 Protein denotes WWOX
T8359 17203-17209 Protein denotes Δ40p53
T8358 17066-17069 Protein denotes p53
T8357 17045-17049 Protein denotes WWOX
T8356 17029-17033 Protein denotes WWOX
T8355 17013-17016 Protein denotes p53
T8354 16784-16793 Protein denotes caspase-3
T8353 16709-16713 Protein denotes WWOX
T8352 16692-16695 Protein denotes p53
T8351 16640-16644 Protein denotes WWOX
T8350 16552-16555 Protein denotes p53
T8349 16482-16486 Protein denotes WWOX
T8348 16343-16347 Protein denotes WWOX
T8347 16282-16286 Protein denotes WWOX
T8346 16205-16208 Protein denotes p53
T8345 16149-16152 Protein denotes p53
T8344 16083-16086 Protein denotes p53
T8343 15852-15855 Protein denotes p53
T7490 15781-15784 Protein denotes Bax
T7489 15773-15776 Protein denotes p21
T7488 15745-15760 Transcription denotes transcriptional
T7487 15741-15744 Protein denotes p53
T7486 15734-15740 Regulation denotes affect
T7485 15721-15724 Protein denotes p53
T7484 15707-15715 Protein denotes Δ133p53γ
T7483 15695-15703 Protein denotes Δ133p53β
T7482 15681-15691 Gene_expression denotes expression
T7481 15678-15681 Gene_expression denotes Co-
T7480 15615-15618 Protein denotes p53
T7479 15563-15570 Protein denotes Δ133p53
T7478 15516-15519 Protein denotes p53
T7477 15497-15504 Protein denotes Δ133p53
T7476 15488-15491 Protein denotes p53
T7475 15474-15484 Gene_expression denotes expression
T7474 15471-15474 Gene_expression denotes co-
T7473 15439-15442 Protein denotes p53
T7472 15424-15428 Protein denotes p53β
T7471 15416-15419 Protein denotes p53
T7470 15334-15342 Protein denotes Δ133p53γ
T7469 15311-15318 Entity denotes nucleus
T7468 15281-15289 Protein denotes Δ133p53β
T7467 15272-15276 Protein denotes p53γ
T7466 15191-15195 Protein denotes p53β
T7465 15178-15185 Protein denotes Δ133p53
T7464 15173-15176 Protein denotes p53
T7463 15091-15094 Protein denotes p53
T7462 15077-15087 Gene_expression denotes expression
T7461 14874-14877 Protein denotes p53
T7460 15781-15784 Protein denotes Bax
T7459 15773-15776 Protein denotes p21
T7458 15741-15744 Protein denotes p53
T7457 15721-15724 Protein denotes p53
T7456 15707-15715 Protein denotes Δ133p53γ
T7455 15695-15703 Protein denotes Δ133p53β
T7454 15615-15618 Protein denotes p53
T7453 15563-15570 Protein denotes Δ133p53
T7452 15516-15519 Protein denotes p53
T7451 15497-15504 Protein denotes Δ133p53
T7450 15488-15491 Protein denotes p53
T7449 15439-15442 Protein denotes p53
T7448 15424-15428 Protein denotes p53β
T7447 15416-15419 Protein denotes p53
T7446 15334-15342 Protein denotes Δ133p53γ
T7445 15281-15289 Protein denotes Δ133p53β
T7444 15272-15276 Protein denotes p53γ
T7443 15191-15195 Protein denotes p53β
T7442 15178-15185 Protein denotes Δ133p53
T7441 15173-15176 Protein denotes p53
T7440 15091-15094 Protein denotes p53
T7439 14874-14877 Protein denotes p53
T6772 13668-13672 Protein denotes VIα1
T6771 13649-13663 Protein denotes collagens IIα1
T6770 13605-13626 Protein denotes smooth muscle α-actin
T6769 13526-13529 Protein denotes p53
T6768 13348-13351 Protein denotes p53
T6767 13317-13322 Protein denotes BCL-2
T6766 13283-13293 Negative_regulation denotes inhibiting
T6765 13274-13277 Protein denotes FAS
T6764 13262-13268 Protein denotes SCOTIN
T6763 13256-13260 Protein denotes PUMA
T6762 13251-13254 Protein denotes BAX
T6761 13183-13186 Protein denotes p53
T6760 13176-13181 Protein denotes miR34
T6759 13159-13162 Protein denotes p21
T6758 13149-13158 Negative_regulation denotes inhibitor
T6757 13062-13065 Protein denotes p53
T6756 13016-13019 Protein denotes p53
T6755 12884-12887 Protein denotes p53
T6754 13668-13672 Protein denotes VIα1
T6753 13649-13663 Protein denotes collagens IIα1
T6752 13605-13626 Protein denotes smooth muscle α-actin
T6751 13526-13529 Protein denotes p53
T6750 13348-13351 Protein denotes p53
T6749 13317-13322 Protein denotes BCL-2
T6748 13274-13277 Protein denotes FAS
T6747 13262-13268 Protein denotes SCOTIN
T6746 13256-13260 Protein denotes PUMA
T6745 13251-13254 Protein denotes BAX
T6744 13183-13186 Protein denotes p53
T6743 13176-13181 Protein denotes miR34
T6742 13159-13162 Protein denotes p21
T6741 13062-13065 Protein denotes p53
T6740 13016-13019 Protein denotes p53
T6739 12884-12887 Protein denotes p53
T3813 12674-12680 Protein denotes Hyal-2
T3812 12668-12673 Binding denotes binds
T3811 12638-12667 Protein denotes Transforming growth factor β1
T3810 12612-12617 Protein denotes Ezrin
T3809 12574-12580 Protein denotes Hyal-2
T3808 12492-12496 Protein denotes WWOX
T3807 12339-12343 Protein denotes WWOX
T3806 12204-12216 Protein denotes procaspase-9
T3805 12187-12199 Protein denotes procaspase-3
T3804 12179-12186 Positive_regulation denotes induces
T3803 12160-12164 Protein denotes WWOX
T3802 12034-12044 Negative_regulation denotes Inhibition
T3801 12005-12014 Binding denotes relocates
T3800 11932-11936 Protein denotes WWOX
T3799 11807-11812 Binding denotes binds
T3798 11802-11806 Protein denotes WWOX
T3797 11650-11665 Phosphorylation denotes phosphorylation
T3796 11635-11639 Protein denotes WWOX
T3795 11527-11530 Protein denotes p53
T3794 11481-11485 Protein denotes WWOX
T3793 11449-11452 Protein denotes p53
T3792 11414-11420 Protein denotes Bcl-xL
T3791 11404-11409 Protein denotes Bcl-2
T3790 11394-11403 Negative_regulation denotes inhibitor
T3789 11368-11383 Negative_regulation denotes down-regulating
T3788 11343-11364 Protein denotes tumor necrosis factor
T3787 11303-11307 Protein denotes WWOX
T3786 11110-11114 Protein denotes WWOX
T3785 11026-11031 Protein denotes Dvl-2
T3784 10984-10989 Protein denotes Dvl-2
T3783 10968-10972 Protein denotes WWOX
T3782 10877-10886 Protein denotes β-catenin
T3781 10807-10811 Protein denotes WWOX
T3780 10747-10750 Protein denotes p53
T3779 10714-10717 Protein denotes p53
T3778 10699-10713 Phosphorylation denotes phosphorylated
T3777 10689-10695 Entity denotes serine
T3776 10674-10683 Binding denotes interacts
T3775 10658-10662 Protein denotes WWOX
T3774 10552-10557 Binding denotes binds
T3773 10522-10537 Phosphorylation denotes phosphorylation
T3772 10508-10517 Positive_regulation denotes activated
T3771 10500-10504 Protein denotes WWOX
T3770 10456-10460 Protein denotes Wwox
T3769 10232-10236 Protein denotes Wwox
T3768 10124-10131 Entity denotes nuclear
T3767 10112-10117 Negative_regulation denotes block
T3766 10102-10107 Protein denotes c-Jun
T3765 10093-10096 Protein denotes p73
T3764 10087-10091 Protein denotes AP-2
T3763 10054-10058 Protein denotes WWOX
T3762 10040-10053 Positive_regulation denotes overexpressed
T3761 9936-9941 Protein denotes RUNX4
T3760 9929-9934 Protein denotes c-Jun
T3759 9921-9927 Protein denotes SIMPLE
T3758 9914-9919 Protein denotes Ezrin
T3757 9907-9912 Protein denotes ErbB4
T3756 9902-9905 Protein denotes p73
T3755 9895-9900 Protein denotes AP-2γ
T3754 9837-9845 Binding denotes interact
T3753 9828-9832 Protein denotes WWOX
T3752 9653-9657 Protein denotes WWOX
T3751 9234-9238 Protein denotes WWOX
T3750 9220-9230 Gene_expression denotes Expression
T3749 7300-7304 Protein denotes WWOX
T3748 7024-7028 Protein denotes WWOX
T3747 6899-6903 Protein denotes Wwox
T3746 6894-6898 Protein denotes WWOX
T3745 6859-6863 Protein denotes WOX1
T3744 6851-6854 Protein denotes FOR
T3743 6845-6849 Protein denotes WWOX
T3742 6799-6834 Protein denotes WW domain-containing oxidoreductase
T3741 6712-6716 Protein denotes WWOX
T3740 6704-6707 Protein denotes p53
T3739 12674-12680 Protein denotes Hyal-2
T3738 12638-12667 Protein denotes Transforming growth factor β1
T3737 12612-12617 Protein denotes Ezrin
T3736 12574-12580 Protein denotes Hyal-2
T3735 12492-12496 Protein denotes WWOX
T3734 12339-12343 Protein denotes WWOX
T3733 12204-12216 Protein denotes procaspase-9
T3732 12187-12199 Protein denotes procaspase-3
T3731 12160-12164 Protein denotes WWOX
T3730 11932-11936 Protein denotes WWOX
T3729 11802-11806 Protein denotes WWOX
T3728 11635-11639 Protein denotes WWOX
T3727 11527-11530 Protein denotes p53
T3726 11481-11485 Protein denotes WWOX
T3725 11449-11452 Protein denotes p53
T3724 11414-11420 Protein denotes Bcl-xL
T3723 11404-11409 Protein denotes Bcl-2
T3722 11343-11364 Protein denotes tumor necrosis factor
T3721 11303-11307 Protein denotes WWOX
T3720 11110-11114 Protein denotes WWOX
T3719 11026-11031 Protein denotes Dvl-2
T3718 10984-10989 Protein denotes Dvl-2
T3717 10968-10972 Protein denotes WWOX
T3716 10877-10886 Protein denotes β-catenin
T3715 10807-10811 Protein denotes WWOX
T3714 10747-10750 Protein denotes p53
T3713 10714-10717 Protein denotes p53
T3712 10658-10662 Protein denotes WWOX
T3711 10500-10504 Protein denotes WWOX
T3710 10456-10460 Protein denotes Wwox
T3709 10232-10236 Protein denotes Wwox
T3708 10102-10107 Protein denotes c-Jun
T3707 10093-10096 Protein denotes p73
T3706 10087-10091 Protein denotes AP-2
T3705 10054-10058 Protein denotes WWOX
T3704 9936-9941 Protein denotes RUNX4
T3703 9929-9934 Protein denotes c-Jun
T3702 9921-9927 Protein denotes SIMPLE
T3701 9914-9919 Protein denotes Ezrin
T3700 9907-9912 Protein denotes ErbB4
T3699 9902-9905 Protein denotes p73
T3698 9895-9900 Protein denotes AP-2γ
T3697 9828-9832 Protein denotes WWOX
T3696 9653-9657 Protein denotes WWOX
T3695 9234-9238 Protein denotes WWOX
T3694 7300-7304 Protein denotes WWOX
T3693 7024-7028 Protein denotes WWOX
T3692 6899-6903 Protein denotes Wwox
T3691 6894-6898 Protein denotes WWOX
T3690 6859-6863 Protein denotes WOX1
T3689 6851-6854 Protein denotes FOR
T3688 6845-6849 Protein denotes WWOX
T3687 6799-6834 Protein denotes WW domain-containing oxidoreductase
T3686 6712-6716 Protein denotes WWOX
T3685 6704-6707 Protein denotes p53
T872 6524-6529 Protein denotes CD133
T871 6376-6381 Protein denotes CD133
T870 5843-5852 Negative_regulation denotes knockdown
T869 5837-5842 Protein denotes STAT3
T868 5824-5833 Negative_regulation denotes inhibitor
T867 5818-5823 Protein denotes STAT3
T866 5639-5643 Protein denotes MGMT
T865 5599-5607 Positive_regulation denotes increase
T864 5533-5538 Protein denotes IFN-β
T863 5519-5531 Protein denotes Interferon-β
T862 5047-5051 Protein denotes MGMT
T861 4393-4396 Protein denotes p53
T860 4177-4188 Protein denotes MicroRNA-21
T859 4098-4107 Protein denotes caspase-3
T858 4082-4087 Protein denotes Bcl-2
T857 4078-4081 Protein denotes Bax
T856 4070-4077 Negative_regulation denotes reduces
T855 4058-4069 Protein denotes microRNA-21
T854 3984-3994 Gene_expression denotes expression
T853 3971-3975 Protein denotes MGMT
T852 3926-3930 Protein denotes MGMT
T851 3914-3922 Positive_regulation denotes increase
T850 3829-3833 Protein denotes MGMT
T849 3787-3797 Binding denotes associated
T848 3520-3524 Protein denotes MGMT
T847 3506-3516 Gene_expression denotes expression
T846 3330-3339 Negative_regulation denotes deficient
T845 3260-3264 Protein denotes MGMT
T844 3158-3162 Protein denotes MGMT
T843 3118-3156 Protein denotes O6-methylguanine-DNA methyltransferase
T842 2946-2951 Protein denotes MAPO2
T841 2844-2852 Protein denotes C1orf201
T840 2837-2842 Protein denotes MAPO2
T839 2563-2572 Negative_regulation denotes inhibitor
T838 2557-2562 Protein denotes Bcl-2
T837 2542-2547 Protein denotes Bcl-2
T836 2514-2524 Negative_regulation denotes inhibition
T835 6524-6529 Protein denotes CD133
T834 6376-6381 Protein denotes CD133
T833 5837-5842 Protein denotes STAT3
T832 5818-5823 Protein denotes STAT3
T831 5639-5643 Protein denotes MGMT
T830 5533-5538 Protein denotes IFN-β
T829 5519-5531 Protein denotes Interferon-β
T828 5047-5051 Protein denotes MGMT
T827 4393-4396 Protein denotes p53
T826 4177-4188 Protein denotes MicroRNA-21
T825 4098-4107 Protein denotes caspase-3
T824 4082-4087 Protein denotes Bcl-2
T823 4078-4081 Protein denotes Bax
T822 4058-4069 Protein denotes microRNA-21
T821 3971-3975 Protein denotes MGMT
T820 3926-3930 Protein denotes MGMT
T819 3829-3833 Protein denotes MGMT
T818 3520-3524 Protein denotes MGMT
T817 3260-3264 Protein denotes MGMT
T816 3158-3162 Protein denotes MGMT
T815 3118-3156 Protein denotes O6-methylguanine-DNA methyltransferase
T814 2946-2951 Protein denotes MAPO2
T813 2844-2852 Protein denotes C1orf201
T812 2837-2842 Protein denotes MAPO2
T811 2557-2562 Protein denotes Bcl-2
T810 2542-2547 Protein denotes Bcl-2
T78 988-991 Protein denotes p53
T77 945-949 Protein denotes WWOX
T76 912-916 Protein denotes WWOX
T75 859-862 Protein denotes p53
T74 793-797 Protein denotes WWOX
T73 785-788 Protein denotes p53
T72 722-725 Protein denotes p53
T71 693-697 Binding denotes bind
T70 665-669 Protein denotes WWOX
T69 660-663 Protein denotes p53
T68 577-581 Protein denotes WWOX
T67 382-386 Protein denotes WWOX
T66 374-378 Negative_regulation denotes Loss
T65 301-305 Protein denotes WOX1
T64 294-297 Protein denotes FOR
T63 288-292 Protein denotes WWOX
T62 252-287 Protein denotes WW domain-containing oxidoreductase
T61 106-109 Protein denotes p53
T58 988-991 Protein denotes p53
T57 945-949 Protein denotes WWOX
T56 912-916 Protein denotes WWOX
T55 859-862 Protein denotes p53
T54 793-797 Protein denotes WWOX
T53 785-788 Protein denotes p53
T52 722-725 Protein denotes p53
T51 665-669 Protein denotes WWOX
T50 660-663 Protein denotes p53
T49 577-581 Protein denotes WWOX
T48 382-386 Protein denotes WWOX
T47 301-305 Protein denotes WOX1
T46 294-297 Protein denotes FOR
T45 288-292 Protein denotes WWOX
T44 252-287 Protein denotes WW domain-containing oxidoreductase
T43 106-109 Protein denotes p53
R5 T63 T64 themeOf WWOX,FOR
R6 T64 T62 equivalentTo FOR,WW domain-containing oxidoreductase
R7 T70 T71 themeOf WWOX,bind
R8 T72 T71 themeOf p53,bind
R455 T837 T836 themeOf Bcl-2,inhibition
R456 T838 T839 themeOf Bcl-2,inhibitor
R457 T841 T840 equivalentTo C1orf201,MAPO2
R458 T844 T843 equivalentTo MGMT,O6-methylguanine-DNA methyltransferase
R459 T848 T847 themeOf MGMT,expression
R460 T853 T854 themeOf MGMT,expression
R461 T864 T863 equivalentTo IFN-β,Interferon-β
R462 T867 T868 themeOf STAT3,inhibitor
R463 T869 T870 themeOf STAT3,knockdown
R2630 T3743 T3744 themeOf WWOX,FOR
R2631 T3745 T3744 themeOf WOX1,FOR
R2632 T3751 T3750 themeOf WWOX,Expression
R2633 T3753 T3754 themeOf WWOX,interact
R2634 T3755 T3754 themeOf AP-2γ,interact
R2635 T3756 T3754 themeOf p73,interact
R2636 T3757 T3754 themeOf ErbB4,interact
R2637 T3758 T3754 themeOf Ezrin,interact
R2638 T3759 T3754 themeOf SIMPLE,interact
R2639 T3760 T3754 themeOf c-Jun,interact
R2640 T3761 T3754 themeOf RUNX4,interact
R2641 T3763 T3762 themeOf WWOX,overexpressed
R2642 T3764 T3762 themeOf AP-2,overexpressed
R2643 T3765 T3762 themeOf p73,overexpressed
R2644 T3766 T3762 themeOf c-Jun,overexpressed
R2645 T3771 T3772 themeOf WWOX,activated
R2646 T3771 T3773 themeOf WWOX,phosphorylation
R2647 T3771 T3774 themeOf WWOX,binds
R2648 T3775 T3776 themeOf WWOX,interacts
R2649 T3777 T3778 themeOf serine,phosphorylated
R2650 T3779 T3778 themeOf p53,phosphorylated
R2651 T3787 T3789 causeOf WWOX,down-regulating
R2652 T3788 T3789 causeOf tumor necrosis factor,down-regulating
R2653 T3788 T3787 themeOf tumor necrosis factor,WWOX
R2654 T3790 T3789 themeOf inhibitor,down-regulating
R2655 T3791 T3790 themeOf Bcl-2,inhibitor
R2656 T3791 T3789 themeOf Bcl-2,down-regulating
R2657 T3792 T3790 themeOf Bcl-xL,inhibitor
R2658 T3792 T3789 themeOf Bcl-xL,down-regulating
R2659 T3793 T3789 themeOf p53,down-regulating
R2660 T3796 T3797 themeOf WWOX,phosphorylation
R2661 T3798 T3799 themeOf WWOX,binds
R2662 T3811 T3812 themeOf Transforming growth factor β1,binds
R2663 T3813 T3812 themeOf Hyal-2,binds
R4779 T6759 T6758 themeOf p21,inhibitor
R4780 T6767 T6766 themeOf BCL-2,inhibiting
R5199 T7463 T7462 themeOf p53,expression
R5200 T7483 T7482 themeOf Δ133p53β,expression
R5201 T7484 T7482 themeOf Δ133p53γ,expression
R5202 T7487 T7488 themeOf p53,transcriptional
R5203 T7488 T7486 themeOf transcriptional,affect
R5771 T8372 T8373 themeOf WWOX,expression
R5772 T8376 T8375 themeOf p53,WWOX
R5773 T8379 T8377 themeOf p53,WWOX
R5774 T8387 T8388 themeOf Δ40p53,binding
R5775 T8389 T8388 themeOf WWOX,binding
R5776 T8396 T8395 themeOf p53,WWOX
R6582 T9684 T9683 themeOf WWOX,Binding
R6583 T9685 T9683 themeOf p53,Binding
R6584 T9686 T9687 themeOf WWOX,binds
R6585 T9691 T9690 themeOf p53,WWOX
R6586 T9692 T9693 themeOf p53,interacts
R6587 T9694 T9693 themeOf WWOX,interacts
R6588 T9703 T9702 themeOf p53,WWOX
R6589 T9708 T9709 themeOf WWOX,expression
R6590 T9709 T9707 themeOf expression,lack
R6591 T9712 T9711 themeOf TIAF1,expression
R6592 T9713 T9711 themeOf p53,expression
R6593 T9714 T9711 themeOf WWOX,expression
R8782 T12735 T12736 themeOf WWOX,phosphorylated
R8783 T12735 T12737 themeOf WWOX,binds
R8784 T12738 T12736 themeOf p53,phosphorylated
R8785 T12738 T12737 themeOf p53,binds
R8786 T12740 T12745 themeOf WWOX,binding
R8787 T12740 T12741 themeOf WWOX,binds
R8788 T12742 T12745 themeOf RUNX2,binding
R8789 T12742 T12741 themeOf RUNX2,binds
R8790 T12743 T12745 themeOf c-Jun,binding
R8791 T12743 T12741 themeOf c-Jun,binds
R8792 T12744 T12745 themeOf ERBB4,binding
R8793 T12744 T12741 themeOf ERBB4,binds
R8794 T12748 T12752 themeOf WWOX,import
R8795 T12748 T12749 themeOf WWOX,binding
R8796 T12751 T12752 locationOf nuclear,import
R8797 T12752 T12750 themeOf import,inhibiting
R8798 T12754 T12756 themeOf WWOX,association
R8799 T12754 T12755 themeOf WWOX,recruited
R8800 T12757 T12756 themeOf Hyal-2,association
R8801 T12759 T12758 themeOf Ezrin,phospho
R8802 T12762 T12764 themeOf TGF-β1,binds
R8803 T12763 T12764 themeOf WWOX,binds
R8804 T12765 T12764 themeOf Hyal-2,binds
R9690 T14064 T14065 themeOf p53,expressing
R9691 T14065 T14063 themeOf expressing,WWOX
R9692 T14069 T14068 themeOf p53,WWOX

testone

Id Subject Object Predicate Lexical cue
T19 17-21 Protein denotes WWOX
T20 26-29 Protein denotes p53
T14030 14653-14663 Gene_expression denotes expressing
T14029 14559-14564 Binding denotes binds
T14028 14519-14529 Gene_expression denotes expressing
T14027 14392-14404 Binding denotes interactions
T14026 14261-14266 Binding denotes binds
T14025 14195-14205 Gene_expression denotes expressing
T14024 14664-14667 Protein denotes p53
T14023 14612-14616 Protein denotes WWOX
T14022 14565-14568 Protein denotes p53
T14021 14554-14558 Protein denotes WWOX
T14020 14515-14518 Protein denotes p53
T14019 14483-14487 Protein denotes WWOX
T14018 14437-14441 Protein denotes WWOX
T14017 14420-14423 Protein denotes p53
T14016 14296-14299 Protein denotes p53
T14015 14256-14260 Protein denotes WWOX
T14014 14227-14230 Protein denotes p53
T14013 14151-14155 Protein denotes WWOX
T14012 14104-14107 Protein denotes p53
T14011 14095-14099 Protein denotes WWOX
T14010 14031-14034 Protein denotes p53
T14009 13772-13775 Protein denotes p53
T14008 13728-13732 Protein denotes WWOX
T14007 13720-13723 Protein denotes p53
T12460 22781-22785 Protein denotes WWOX
T12459 22773-22776 Protein denotes p53
T12707 9010-9017 Entity denotes nucleus
T12706 8946-8951 Binding denotes binds
T12705 8829-8840 Binding denotes association
T12704 8795-8804 Binding denotes recruited
T12703 8620-8626 Localization denotes import
T12702 8612-8619 Entity denotes nuclear
T12701 8597-8607 Negative_regulation denotes inhibiting
T12700 8581-8588 Binding denotes binding
T12699 8494-8499 Binding denotes binds
T12698 8290-8295 Binding denotes binds
T12697 8251-8258 Entity denotes nucleus
T12696 8219-8231 Localization denotes translocates
T12695 8182-8187 Binding denotes binds
T12694 8154-8168 Phosphorylation denotes phosphorylated
T12693 9118-9144 Protein denotes hyaluronoglucosaminidase 2
T12692 9110-9116 Protein denotes Hyal-2
T12691 9073-9108 Protein denotes activated Cdc42-associated kinase 1
T12690 9067-9071 Protein denotes Ack1
T12689 8952-8958 Protein denotes Hyal-2
T12688 8941-8945 Protein denotes WWOX
T12687 8933-8939 Protein denotes TGF-β1
T12686 8910-8916 Protein denotes TGF-β1
T12685 8872-8878 Protein denotes Hyal-2
T12684 8865-8870 Protein denotes Ezrin
T12683 8846-8852 Protein denotes Hyal-2
T12682 8787-8791 Protein denotes WWOX
T12681 8725-8729 Protein denotes WWOX
T12680 8524-8528 Protein denotes WWOX
T12679 8500-8503 Protein denotes Tau
T12678 8489-8493 Protein denotes WWOX
T12677 8367-8372 Protein denotes ERBB4
T12676 8356-8361 Protein denotes c-Jun
T12675 8349-8354 Protein denotes RUNX2
T12674 8280-8284 Protein denotes WWOX
T12673 8188-8191 Protein denotes p53
T12672 8146-8150 Protein denotes WWOX
T12671 7575-7579 Protein denotes WWOX
T12670 7533-7537 Protein denotes WWOX
T9637 22595-22605 Negative_regulation denotes deficiency
T9636 22432-22442 Regulation denotes regulating
T9635 22021-22031 Gene_expression denotes production
T9634 22009-22016 Positive_regulation denotes induces
T9633 21407-21417 Gene_expression denotes expression
T9632 21372-21382 Gene_expression denotes expressing
T9631 21229-21237 Gene_expression denotes negative
T9630 20519-20529 Gene_expression denotes expression
T9629 20511-20518 Negative_regulation denotes Ectopic
T9628 20325-20335 Gene_expression denotes expression
T9627 20312-20316 Negative_regulation denotes lack
T9626 20073-20084 Binding denotes interacting
T9625 18845-18854 Binding denotes interacts
T9624 18251-18261 Negative_regulation denotes inhibition
T9623 17848-17853 Binding denotes binds
T9622 22590-22594 Protein denotes WWOX
T9621 22499-22503 Protein denotes WWOX
T9620 22424-22428 Protein denotes WWOX
T9619 22416-22419 Protein denotes p53
T9618 22181-22185 Protein denotes WWOX
T9617 21988-21992 Protein denotes Wwox
T9616 21823-21827 Protein denotes Wwox
T9615 21622-21626 Protein denotes Wwox
T9614 21463-21467 Protein denotes WWOX
T9613 21402-21406 Protein denotes WWOX
T9612 21367-21371 Protein denotes WWOX
T9611 21300-21304 Protein denotes WWOX
T9610 21266-21270 Protein denotes WWOX
T9609 21224-21228 Protein denotes WWOX
T9608 21168-21172 Protein denotes WWOX
T9607 21119-21123 Protein denotes WWOX
T9606 21067-21071 Protein denotes WWOX
T9605 20876-20880 Protein denotes Wwox
T9604 20586-20590 Protein denotes WWOX
T9603 20577-20580 Protein denotes p53
T9602 20533-20538 Protein denotes TIAF1
T9601 20396-20400 Protein denotes WWOX
T9600 20320-20324 Protein denotes WWOX
T9599 20050-20054 Protein denotes CD44
T9598 19903-19907 Protein denotes mTOR
T9597 19898-19901 Protein denotes Akt
T9596 19706-19709 Protein denotes p53
T9595 19657-19661 Protein denotes WWOX
T9594 19321-19325 Protein denotes PTEN
T9593 19314-19319 Protein denotes Smad4
T9592 19308-19312 Protein denotes WWOX
T9591 19303-19306 Protein denotes p53
T9590 19126-19129 Protein denotes p53
T9589 19117-19121 Protein denotes WWOX
T9588 19023-19026 Protein denotes p53
T9587 18860-18864 Protein denotes WWOX
T9586 18828-18831 Protein denotes p53
T9585 18756-18759 Protein denotes p53
T9584 18692-18696 Protein denotes WWOX
T9583 18631-18635 Protein denotes WWOX
T9582 17843-17847 Protein denotes WWOX
T9581 17774-17777 Protein denotes p53
T9580 17762-17766 Protein denotes WWOX
T9579 17685-17689 Protein denotes WWOX
T8342 17597-17607 Gene_expression denotes expressing
T8341 17211-17218 Binding denotes binding
T8340 17081-17096 Phosphorylation denotes phosphorylation
T8339 17050-17055 Binding denotes binds
T8338 17035-17044 Positive_regulation denotes Activated
T8337 16968-16980 Binding denotes interactions
T8336 16671-16681 Gene_expression denotes expressing
T8335 16652-16658 Regulation denotes effect
T8334 16287-16297 Gene_expression denotes expression
T8333 16274-16281 Regulation denotes Altered
T8332 16217-16223 Negative_regulation denotes reduce
T8331 17608-17611 Protein denotes p53
T8330 17568-17572 Protein denotes WWOX
T8329 17526-17530 Protein denotes WWOX
T8328 17503-17507 Protein denotes WWOX
T8327 17470-17473 Protein denotes p53
T8326 17334-17338 Protein denotes WWOX
T8325 17318-17321 Protein denotes p53
T8324 17240-17244 Protein denotes WWOX
T8323 17203-17209 Protein denotes Δ40p53
T8322 17066-17069 Protein denotes p53
T8321 17045-17049 Protein denotes WWOX
T8320 17029-17033 Protein denotes WWOX
T8319 17013-17016 Protein denotes p53
T8318 16784-16793 Protein denotes caspase-3
T8317 16709-16713 Protein denotes WWOX
T8316 16692-16695 Protein denotes p53
T8315 16640-16644 Protein denotes WWOX
T8314 16552-16555 Protein denotes p53
T8313 16482-16486 Protein denotes WWOX
T8312 16343-16347 Protein denotes WWOX
T8311 16282-16286 Protein denotes WWOX
T8310 16205-16208 Protein denotes p53
T8309 16149-16152 Protein denotes p53
T8308 16083-16086 Protein denotes p53
T8307 15852-15855 Protein denotes p53
T7438 15678-15691 Gene_expression denotes Co-expression
T7437 15471-15484 Gene_expression denotes co-expression
T7436 15346-15355 Localization denotes localized
T7435 15781-15784 Protein denotes Bax
T7434 15773-15776 Protein denotes p21
T7433 15741-15744 Protein denotes p53
T7432 15721-15724 Protein denotes p53
T7431 15707-15715 Protein denotes Δ133p53γ
T7430 15695-15703 Protein denotes Δ133p53β
T7429 15615-15618 Protein denotes p53
T7428 15563-15570 Protein denotes Δ133p53
T7427 15516-15519 Protein denotes p53
T7426 15497-15504 Protein denotes Δ133p53
T7425 15488-15491 Protein denotes p53
T7424 15439-15442 Protein denotes p53
T7423 15424-15428 Protein denotes p53β
T7422 15416-15419 Protein denotes p53
T7421 15334-15342 Protein denotes Δ133p53γ
T7420 15281-15289 Protein denotes Δ133p53β
T7419 15272-15276 Protein denotes p53γ
T7418 15191-15195 Protein denotes p53β
T7417 15178-15185 Protein denotes Δ133p53
T7416 15173-15176 Protein denotes p53
T7415 15091-15094 Protein denotes p53
T7414 14874-14877 Protein denotes p53
T6738 13591-13601 Gene_expression denotes expression
T6737 13576-13586 Regulation denotes regulating
T6736 13283-13293 Negative_regulation denotes inhibiting
T6735 13668-13672 Protein denotes VIα1
T6734 13649-13663 Protein denotes collagens IIα1
T6733 13605-13626 Protein denotes smooth muscle α-actin
T6732 13526-13529 Protein denotes p53
T6731 13348-13351 Protein denotes p53
T6730 13317-13322 Protein denotes BCL-2
T6729 13274-13277 Protein denotes FAS
T6728 13262-13268 Protein denotes SCOTIN
T6727 13256-13260 Protein denotes PUMA
T6726 13251-13254 Protein denotes BAX
T6725 13183-13186 Protein denotes p53
T6724 13176-13181 Protein denotes miR34
T6723 13159-13162 Protein denotes p21
T6722 13062-13065 Protein denotes p53
T6721 13016-13019 Protein denotes p53
T6720 12884-12887 Protein denotes p53
T3684 12779-12786 Entity denotes nucleus
T3683 12668-12673 Binding denotes binds
T3682 12547-12554 Binding denotes binding
T3681 12217-12227 Positive_regulation denotes activation
T3680 12179-12186 Positive_regulation denotes induces
T3679 12005-12014 Localization denotes relocates
T3678 11940-11951 Localization denotes translocate
T3677 11924-11931 Positive_regulation denotes induces
T3676 11807-11812 Binding denotes binds
T3675 10812-10817 Binding denotes binds
T3674 10699-10713 Phosphorylation denotes phosphorylated
T3673 10674-10683 Binding denotes interacts
T3672 10552-10557 Binding denotes binds
T3671 10522-10537 Phosphorylation denotes phosphorylation
T3670 10124-10131 Entity denotes nuclear
T3669 10112-10117 Negative_regulation denotes block
T3668 9837-9845 Binding denotes interact
T3667 9220-9230 Gene_expression denotes Expression
T3666 12674-12680 Protein denotes Hyal-2
T3665 12638-12667 Protein denotes Transforming growth factor β1
T3664 12612-12617 Protein denotes Ezrin
T3663 12574-12580 Protein denotes Hyal-2
T3662 12492-12496 Protein denotes WWOX
T3661 12339-12343 Protein denotes WWOX
T3660 12204-12216 Protein denotes procaspase-9
T3659 12187-12199 Protein denotes procaspase-3
T3658 12160-12164 Protein denotes WWOX
T3657 11932-11936 Protein denotes WWOX
T3656 11802-11806 Protein denotes WWOX
T3655 11635-11639 Protein denotes WWOX
T3654 11527-11530 Protein denotes p53
T3653 11481-11485 Protein denotes WWOX
T3652 11449-11452 Protein denotes p53
T3651 11414-11420 Protein denotes Bcl-xL
T3650 11404-11409 Protein denotes Bcl-2
T3649 11343-11364 Protein denotes tumor necrosis factor
T3648 11303-11307 Protein denotes WWOX
T3647 11110-11114 Protein denotes WWOX
T3646 11026-11031 Protein denotes Dvl-2
T3645 10984-10989 Protein denotes Dvl-2
T3644 10968-10972 Protein denotes WWOX
T3643 10877-10886 Protein denotes β-catenin
T3642 10807-10811 Protein denotes WWOX
T3641 10747-10750 Protein denotes p53
T3640 10714-10717 Protein denotes p53
T3639 10658-10662 Protein denotes WWOX
T3638 10500-10504 Protein denotes WWOX
T3637 10456-10460 Protein denotes Wwox
T3636 10232-10236 Protein denotes Wwox
T3635 10102-10107 Protein denotes c-Jun
T3634 10093-10096 Protein denotes p73
T3633 10087-10091 Protein denotes AP-2
T3632 10054-10058 Protein denotes WWOX
T3631 9936-9941 Protein denotes RUNX4
T3630 9929-9934 Protein denotes c-Jun
T3629 9921-9927 Protein denotes SIMPLE
T3628 9914-9919 Protein denotes Ezrin
T3627 9907-9912 Protein denotes ErbB4
T3626 9902-9905 Protein denotes p73
T3625 9895-9900 Protein denotes AP-2γ
T3624 9828-9832 Protein denotes WWOX
T3623 9653-9657 Protein denotes WWOX
T3622 9234-9238 Protein denotes WWOX
T3621 7300-7304 Protein denotes WWOX
T3620 7024-7028 Protein denotes WWOX
T3619 6899-6903 Protein denotes Wwox
T3618 6894-6898 Protein denotes WWOX
T3617 6859-6863 Protein denotes WOX1
T3616 6851-6854 Protein denotes FOR
T3615 6845-6849 Protein denotes WWOX
T3614 6799-6834 Protein denotes WW domain-containing oxidoreductase
T3613 6712-6716 Protein denotes WWOX
T3612 6704-6707 Protein denotes p53
T793 5519-5531 Protein denotes Interferon-β
T792 5047-5051 Protein denotes MGMT
T791 4393-4396 Protein denotes p53
T790 4177-4188 Protein denotes MicroRNA-21
T789 4098-4107 Protein denotes caspase-3
T788 4082-4087 Protein denotes Bcl-2
T787 4078-4081 Protein denotes Bax
T786 4058-4069 Protein denotes microRNA-21
T785 3971-3975 Protein denotes MGMT
T784 3926-3930 Protein denotes MGMT
T783 3829-3833 Protein denotes MGMT
T782 3520-3524 Protein denotes MGMT
T781 3260-3264 Protein denotes MGMT
T780 3158-3162 Protein denotes MGMT
T779 3118-3156 Protein denotes O6-methylguanine-DNA methyltransferase
T778 2946-2951 Protein denotes MAPO2
T777 2844-2852 Protein denotes C1orf201
T776 2837-2842 Protein denotes MAPO2
T775 2557-2562 Protein denotes Bcl-2
T774 2542-2547 Protein denotes Bcl-2
T809 6413-6422 Gene_expression denotes expressed
T808 5853-5864 Negative_regulation denotes potentiates
T807 5843-5852 Negative_regulation denotes knockdown
T806 5824-5833 Negative_regulation denotes inhibitor
T805 5599-5607 Positive_regulation denotes increase
T804 3984-3994 Gene_expression denotes expression
T803 3506-3516 Gene_expression denotes expression
T802 3330-3339 Negative_regulation denotes deficient
T801 2563-2572 Negative_regulation denotes inhibitor
T800 2514-2524 Negative_regulation denotes inhibition
T799 6524-6529 Protein denotes CD133
T798 6376-6381 Protein denotes CD133
T797 5837-5842 Protein denotes STAT3
T796 5818-5823 Protein denotes STAT3
T795 5639-5643 Protein denotes MGMT
T794 5533-5538 Protein denotes IFN-β
T40 693-697 Binding denotes bind
T39 521-529 Negative_regulation denotes blockade
T38 392-402 Gene_expression denotes expression
T37 374-378 Negative_regulation denotes Loss
T36 988-991 Protein denotes p53
T35 945-949 Protein denotes WWOX
T34 912-916 Protein denotes WWOX
T33 859-862 Protein denotes p53
T32 793-797 Protein denotes WWOX
T31 785-788 Protein denotes p53
T30 722-725 Protein denotes p53
T29 665-669 Protein denotes WWOX
T28 660-663 Protein denotes p53
T27 577-581 Protein denotes WWOX
T26 382-386 Protein denotes WWOX
T25 301-305 Protein denotes WOX1
T24 294-297 Protein denotes FOR
T23 288-292 Protein denotes WWOX
T22 252-287 Protein denotes WW domain-containing oxidoreductase
T21 106-109 Protein denotes p53
R1 T26 T38 themeOf WWOX,expression
R2 T29 T40 themeOf WWOX,bind
R4 T38 T37 themeOf expression,Loss
R444 T774 T800 themeOf Bcl-2,inhibition
R445 T775 T801 themeOf Bcl-2,inhibitor
R446 T777 T776 equivalentTo C1orf201,MAPO2
R447 T780 T779 equivalentTo MGMT,O6-methylguanine-DNA methyltransferase
R448 T782 T803 themeOf MGMT,expression
R449 T785 T804 themeOf MGMT,expression
R450 T793 T805 causeOf Interferon-β,increase
R451 T794 T793 equivalentTo IFN-β,Interferon-β
R452 T796 T806 themeOf STAT3,inhibitor
R453 T797 T807 themeOf STAT3,knockdown
R454 T798 T809 themeOf CD133,expressed
R2604 T3622 T3667 themeOf WWOX,Expression
R2605 T3624 T3668 themeOf WWOX,interact
R2606 T3625 T3668 themeOf AP-2γ,interact
R2607 T3626 T3668 themeOf p73,interact
R2608 T3627 T3668 themeOf ErbB4,interact
R2609 T3628 T3668 themeOf Ezrin,interact
R2610 T3629 T3668 themeOf SIMPLE,interact
R2611 T3630 T3668 themeOf c-Jun,interact
R2612 T3631 T3668 themeOf RUNX4,interact
R2613 T3635 T3669 causeOf c-Jun,block
R2614 T3638 T3672 themeOf WWOX,binds
R2615 T3639 T3673 themeOf WWOX,interacts
R2616 T3642 T3675 themeOf WWOX,binds
R2617 T3656 T3676 themeOf WWOX,binds
R2618 T3657 T3678 themeOf WWOX,translocate
R2619 T3657 T3677 themeOf WWOX,induces
R2620 T3659 T3681 themeOf procaspase-3,activation
R2621 T3659 T3680 themeOf procaspase-3,induces
R2622 T3660 T3681 themeOf procaspase-9,activation
R2623 T3663 T3682 themeOf Hyal-2,binding
R2624 T3664 T3682 themeOf Ezrin,binding
R2625 T3665 T3683 themeOf Transforming growth factor β1,binds
R2626 T3666 T3683 themeOf Hyal-2,binds
R2627 T3678 T3677 themeOf translocate,induces
R2628 T3679 T3677 themeOf relocates,induces
R2629 T3681 T3680 themeOf activation,induces
R4771 T6728 T6736 causeOf SCOTIN,inhibiting
R4772 T6729 T6736 causeOf FAS,inhibiting
R4773 T6730 T6736 themeOf BCL-2,inhibiting
R4774 T6732 T6737 causeOf p53,regulating
R4775 T6733 T6738 themeOf smooth muscle α-actin,expression
R4776 T6734 T6738 themeOf collagens IIα1,expression
R4777 T6735 T6738 themeOf VIα1,expression
R4778 T6738 T6737 themeOf expression,regulating
R5193 T7421 T7436 themeOf Δ133p53γ,localized
R5194 T7425 T7437 themeOf p53,co-expression
R5195 T7426 T7437 themeOf Δ133p53,co-expression
R5196 T7430 T7438 themeOf Δ133p53β,Co-expression
R5197 T7431 T7438 themeOf Δ133p53γ,Co-expression
R5198 T7432 T7438 themeOf p53,Co-expression
R5760 T8310 T8332 causeOf p53,reduce
R5761 T8311 T8334 themeOf WWOX,expression
R5762 T8320 T8337 themeOf WWOX,interactions
R5763 T8321 T8339 themeOf WWOX,binds
R5764 T8322 T8340 themeOf p53,phosphorylation
R5765 T8322 T8339 themeOf p53,binds
R5766 T8323 T8341 themeOf Δ40p53,binding
R5767 T8324 T8341 themeOf WWOX,binding
R5768 T8334 T8333 themeOf expression,Altered
R5769 T8336 T8335 themeOf expressing,effect
R5770 T8339 T8338 themeOf binds,Activated
R6568 T9582 T9623 themeOf WWOX,binds
R6569 T9586 T9625 themeOf p53,interacts
R6570 T9587 T9625 themeOf WWOX,interacts
R6571 T9599 T9626 themeOf CD44,interacting
R6572 T9600 T9628 themeOf WWOX,expression
R6573 T9602 T9630 themeOf TIAF1,expression
R6574 T9604 T9630 themeOf WWOX,expression
R6575 T9609 T9631 themeOf WWOX,negative
R6576 T9612 T9632 themeOf WWOX,expressing
R6577 T9613 T9633 themeOf WWOX,expression
R6578 T9622 T9637 themeOf WWOX,deficiency
R6579 T9628 T9627 themeOf expression,lack
R6580 T9630 T9629 themeOf expression,Ectopic
R6581 T9635 T9634 themeOf production,induces
R8762 T12672 T12694 themeOf WWOX,phosphorylated
R8763 T12672 T12695 themeOf WWOX,binds
R8764 T12673 T12695 themeOf p53,binds
R8765 T12674 T12698 themeOf WWOX,binds
R8766 T12675 T12698 themeOf RUNX2,binds
R8767 T12676 T12698 themeOf c-Jun,binds
R8768 T12677 T12698 themeOf ERBB4,binds
R8769 T12678 T12699 themeOf WWOX,binds
R8770 T12679 T12699 themeOf Tau,binds
R8771 T12680 T12700 themeOf WWOX,binding
R8772 T12682 T12705 themeOf WWOX,association
R8773 T12682 T12704 themeOf WWOX,recruited
R8774 T12683 T12705 themeOf Hyal-2,association
R8775 T12684 T12705 themeOf Ezrin,association
R8776 T12687 T12706 themeOf TGF-β1,binds
R8777 T12688 T12706 themeOf WWOX,binds
R8778 T12689 T12706 themeOf Hyal-2,binds
R8779 T12697 T12696 locationOf nucleus,translocates
R8780 T12702 T12703 locationOf nuclear,import
R8781 T12703 T12701 themeOf import,inhibiting
R9681 T14014 T14025 themeOf p53,expressing
R9682 T14015 T14026 themeOf WWOX,binds
R9683 T14016 T14026 themeOf p53,binds
R9684 T14017 T14027 themeOf p53,interactions
R9685 T14018 T14027 themeOf WWOX,interactions
R9686 T14020 T14028 themeOf p53,expressing
R9687 T14021 T14029 themeOf WWOX,binds
R9688 T14022 T14029 themeOf p53,binds
R9689 T14024 T14030 themeOf p53,expressing
R3 T30 T40 themeOf p53,bind

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T474 6-21 Protein denotes Suppressor WWOX
T475 26-29 Protein denotes p53
T14524 14653-14663 Gene_expression denotes expressing
T14523 14664-14676 Protein denotes p53 isoforms
T14522 14554-14577 Protein denotes WWOX binds p53 isoforms
T14521 14519-14529 Gene_expression denotes expressing
T14520 14515-14518 Protein denotes p53
T14519 14392-14404 Binding denotes interactions
T14518 14437-14441 Protein denotes WWOX
T14517 14413-14432 Protein denotes mutant p53 proteins
T14516 14261-14266 Binding denotes binds
T14515 14296-14299 Protein denotes p53
T14514 14256-14260 Protein denotes WWOX
T14513 14195-14205 Gene_expression denotes expressing
T14512 14206-14230 Protein denotes endogenous wild type p53
T14511 14104-14107 Protein denotes p53
T14510 14095-14099 Protein denotes WWOX
T14509 14031-14034 Protein denotes p53
T14508 13760-13775 Protein denotes Full-length p53
T14507 13728-13732 Protein denotes WWOX
T14506 13720-13723 Protein denotes p53
T13556 9202-9218 Protein denotes protein kinase A
T13555 9197-9200 Protein denotes PKA
T13554 9171-9195 Protein denotes glycogen synthase kinase
T13553 9166-9169 Protein denotes GSK
T13552 9151-9164 Protein denotes casein kinase
T13551 9146-9149 Protein denotes CKI
T13550 9110-9144 Protein denotes Hyal-2, hyaluronoglucosaminidase 2
T13549 9083-9108 Protein denotes Cdc42-associated kinase 1
T13548 9067-9071 Protein denotes Ack1
T13547 9022-9031 Positive_regulation denotes enhancing
T13546 8971-8978 Binding denotes complex
T13545 8946-8951 Binding denotes binds
T13544 9036-9056 Protein denotes SMAD-driven promoter
T13543 8941-8945 Protein denotes WWOX
T13542 8933-8939 Protein denotes TGF-β1
T13541 8910-8916 Protein denotes TGF-β1
T13540 8829-8840 Binding denotes association
T13539 8829-8840 Binding denotes association
T13538 8795-8804 Binding denotes recruited
T13537 8857-8870 Protein denotes phospho-Ezrin
T13536 8846-8852 Protein denotes Hyal-2
T13535 8787-8791 Protein denotes WWOX
T13534 8677-8681 Protein denotes WWOX
T13533 8673-8676 Protein denotes MEK
T13532 8612-8619 Entity denotes nuclear
T13531 8581-8588 Binding denotes binding
T13530 8589-8592 Protein denotes Dvl
T13529 8553-8562 Protein denotes β-catenin
T13528 8549-8552 Protein denotes Wnt
T13527 8524-8528 Protein denotes WWOX
T13526 8494-8499 Binding denotes binds
T13525 8516-8522 Entity denotes domain
T13524 8512-8515 Protein denotes SDR
T13523 8500-8503 Protein denotes Tau
T13522 8415-8421 Negative_regulation denotes blocks
T13521 8415-8421 Negative_regulation denotes blocks
T13520 8415-8421 Negative_regulation denotes blocks
T13519 8407-8414 Binding denotes binding
T13518 8407-8414 Binding denotes binding
T13517 8407-8414 Binding denotes binding
T13516 8290-8295 Binding denotes binds
T13515 8290-8295 Binding denotes binds
T13514 8290-8295 Binding denotes binds
T13513 8367-8372 Protein denotes ERBB4
T13512 8356-8361 Protein denotes c-Jun
T13511 8349-8354 Protein denotes RUNX2
T13510 8202-8205 Protein denotes p53
T13509 8197-8201 Protein denotes WWOX
T13508 8182-8187 Binding denotes binds
T13507 8154-8168 Phosphorylation denotes phosphorylated
T13506 8154-8168 Phosphorylation denotes phosphorylated
T13505 8188-8191 Protein denotes p53
T13504 8172-8177 Protein denotes Tyr33
T13503 8146-8150 Protein denotes WWOX
T13502 7988-7994 Protein denotes Tyr287
T13501 7978-7983 Protein denotes Tyr33
T13500 7870-7880 Protein denotes SDR domain
T13499 7674-7677 Protein denotes SDR
T13498 7641-7672 Protein denotes alcohol dehydrogenase/reductase
T13497 7575-7579 Protein denotes WWOX
T12533 22811-22814 Protein denotes Jen
T12532 22781-22785 Protein denotes WWOX
T12531 22773-22776 Protein denotes p53
T11348 18756-18759 Protein denotes p53
T11347 18692-18696 Protein denotes WWOX
T11346 18639-18648 Positive_regulation denotes activated
T11345 18631-18635 Protein denotes WWOX
T11344 18440-18443 Protein denotes C1q
T11343 18251-18261 Negative_regulation denotes inhibition
T11342 18265-18268 Protein denotes MEK
T11341 18015-18018 Protein denotes MEK
T11340 18010-18014 Protein denotes WWOX
T11339 17848-17853 Binding denotes binds
T11338 17848-17853 Binding denotes binds
T11337 17848-17853 Binding denotes binds
T11336 17940-17943 Protein denotes Lin
T11335 17854-17857 Protein denotes MEK
T11334 17843-17847 Protein denotes WWOX
T11333 17741-17748 Binding denotes Binding
T11332 17741-17748 Binding denotes Binding
T11331 17741-17748 Binding denotes Binding
T11330 17774-17777 Protein denotes p53
T11329 17762-17766 Protein denotes WWOX
T11403 22595-22605 Negative_regulation denotes deficiency
T11402 22590-22594 Protein denotes WWOX
T11401 22499-22503 Protein denotes WWOX
T11400 22424-22428 Protein denotes WWOX
T11399 22416-22419 Protein denotes p53
T11398 22181-22185 Protein denotes WWOX
T11397 22021-22031 Gene_expression denotes production
T11396 21998-22008 Gene_expression denotes expression
T11395 22017-22020 Protein denotes ROS
T11394 21988-21997 Protein denotes Wwox gene
T11393 21372-21382 Gene_expression denotes expressing
T11392 21367-21371 Protein denotes WWOX
T11391 21229-21237 Gene_expression denotes negative
T11390 21224-21228 Protein denotes WWOX
T11389 21067-21071 Protein denotes WWOX
T11388 20519-20529 Gene_expression denotes expression
T11387 20519-20529 Gene_expression denotes expression
T11386 20519-20529 Gene_expression denotes expression
T11385 20586-20590 Protein denotes WWOX
T11384 20577-20580 Protein denotes p53
T11383 20540-20545 Protein denotes TGF-β
T11382 20533-20538 Protein denotes TIAF1
T11381 20312-20316 Negative_regulation denotes lack
T11380 20325-20335 Gene_expression denotes expression
T11379 20320-20324 Protein denotes WWOX
T11378 20073-20084 Binding denotes interacting
T11377 20073-20084 Binding denotes interacting
T11376 20042-20049 Gene_expression denotes possess
T11375 20042-20049 Gene_expression denotes possess
T11374 20042-20049 Gene_expression denotes possess
T11373 20189-20207 Protein denotes metalloproteinases
T11372 20162-20184 Protein denotes secrete hyaluronidases
T11371 20050-20054 Protein denotes CD44
T11370 19909-19914 Protein denotes NF-κB
T11369 19903-19907 Protein denotes mTOR
T11368 19898-19901 Protein denotes Akt
T11367 19892-19896 Protein denotes PI3K
T11366 19662-19673 Binding denotes counteracts
T11365 19683-19709 Protein denotes function of endogenous p53
T11364 19361-19372 Positive_regulation denotes upregulated
T11363 19361-19372 Positive_regulation denotes upregulated
T11362 19361-19372 Positive_regulation denotes upregulated
T11361 19361-19372 Positive_regulation denotes upregulated
T11360 19361-19372 Positive_regulation denotes upregulated
T11359 19327-19331 Protein denotes PP2A
T11358 19321-19325 Protein denotes PTEN
T11357 19314-19319 Protein denotes Smad4
T11356 19308-19312 Protein denotes WWOX
T11355 19303-19306 Protein denotes p53
T11354 19126-19129 Protein denotes p53
T11353 19117-19121 Protein denotes WWOX
T11352 19023-19043 Protein denotes p53-binding proteins
T11351 18845-18854 Binding denotes interacts
T11350 18860-18864 Protein denotes WWOX
T11349 18828-18831 Protein denotes p53
T9091 17597-17607 Gene_expression denotes expressing
T9090 17608-17620 Protein denotes p53 isoforms
T9089 17490-17494 Binding denotes bind
T9088 17526-17530 Protein denotes WWOX
T9087 17463-17482 Protein denotes Mutant p53 proteins
T9086 17334-17347 Protein denotes WWOX proteins
T9085 17308-17321 Protein denotes wild type p53
T9084 17211-17218 Binding denotes binding
T9083 17240-17244 Protein denotes WWOX
T9082 17081-17096 Phosphorylation denotes phosphorylation
T9081 17050-17055 Binding denotes binds
T9080 17035-17044 Positive_regulation denotes Activated
T9079 17066-17069 Protein denotes p53
T9078 17045-17049 Protein denotes WWOX
T9077 17029-17033 Protein denotes WWOX
T9076 17013-17024 Protein denotes p53 mutants
T9075 16784-16793 Protein denotes caspase-3
T9074 16671-16681 Gene_expression denotes expressing
T9073 16692-16695 Protein denotes p53
T9072 16640-16644 Protein denotes WWOX
T9071 16552-16555 Protein denotes p53
T9070 16274-16281 Regulation denotes Altered
T9069 16325-16339 Negative_regulation denotes downregulation
T9068 16287-16297 Gene_expression denotes expression
T9067 16343-16347 Protein denotes WWOX
T9066 16282-16286 Protein denotes WWOX
T9065 16205-16216 Protein denotes p53 mutants
T9064 16064-16068 Negative_regulation denotes Loss
T9063 16139-16152 Protein denotes wild type p53
T9062 16083-16086 Protein denotes p53
T9061 15852-15863 Protein denotes p53 mutants
T7988 15734-15740 Regulation denotes affect
T7987 15734-15740 Regulation denotes affect
T7986 15678-15691 Gene_expression denotes Co-expression
T7985 15678-15691 Gene_expression denotes Co-expression
T7984 15781-15794 Protein denotes Bax promoters
T7983 15773-15776 Protein denotes p21
T7982 15741-15744 Protein denotes p53
T7981 15721-15724 Protein denotes p53
T7980 15695-15703 Protein denotes Δ133p53β
T7979 15615-15618 Protein denotes p53
T7978 15563-15570 Protein denotes Δ133p53
T7977 15471-15484 Gene_expression denotes co-expression
T7976 15471-15484 Gene_expression denotes co-expression
T7975 15429-15438 Positive_regulation denotes increases
T7974 15429-15438 Positive_regulation denotes increases
T7973 15429-15438 Positive_regulation denotes increases
T7972 15429-15438 Positive_regulation denotes increases
T7971 15397-15412 Positive_regulation denotes Co-transfection
T7970 15397-15412 Positive_regulation denotes Co-transfection
T7969 15397-15412 Gene_expression denotes Co-transfection
T7968 15397-15412 Gene_expression denotes Co-transfection
T7967 15516-15519 Protein denotes p53
T7966 15497-15504 Protein denotes Δ133p53
T7965 15488-15491 Protein denotes p53
T7964 15439-15442 Protein denotes p53
T7963 15424-15428 Protein denotes p53β
T7962 15416-15419 Protein denotes p53
T7961 15346-15355 Localization denotes localized
T7960 15334-15342 Protein denotes Δ133p53γ
T7959 15294-15303 Localization denotes localized
T7958 15294-15303 Localization denotes localized
T7957 15294-15303 Localization denotes localized
T7956 15294-15303 Localization denotes localized
T7955 15323-15332 Entity denotes cytoplasm
T7954 15311-15318 Entity denotes nucleus
T7953 15281-15289 Protein denotes Δ133p53β
T7952 15272-15276 Protein denotes p53γ
T7951 15200-15209 Localization denotes localized
T7950 15200-15209 Localization denotes localized
T7949 15224-15231 Entity denotes nucleus
T7948 15191-15195 Protein denotes p53β
T7947 15161-15185 Protein denotes Full-length p53, Δ133p53
T7946 15077-15087 Gene_expression denotes expression
T7945 15091-15103 Protein denotes p53 isoforms
T7944 14874-14877 Protein denotes p53
T7154 13546-13557 Regulation denotes controlling
T7153 13546-13557 Regulation denotes controlling
T7152 13546-13557 Regulation denotes controlling
T7151 13546-13557 Regulation denotes controlling
T7150 13576-13586 Regulation denotes regulating
T7149 13576-13586 Regulation denotes regulating
T7148 13576-13586 Regulation denotes regulating
T7147 13576-13586 Regulation denotes regulating
T7146 13591-13601 Gene_expression denotes expression
T7145 13591-13601 Gene_expression denotes expression
T7144 13591-13601 Gene_expression denotes expression
T7143 13591-13601 Gene_expression denotes expression
T7142 13674-13677 Protein denotes Sun
T7141 13668-13672 Protein denotes VIα1
T7140 13649-13663 Protein denotes collagens IIα1
T7139 13605-13626 Protein denotes smooth muscle α-actin
T7138 13526-13529 Protein denotes p53
T7137 13348-13351 Protein denotes p53
T7136 13283-13293 Negative_regulation denotes inhibiting
T7135 13298-13322 Protein denotes antiapoptotic gene BCL-2
T7134 13274-13277 Protein denotes FAS
T7133 13167-13186 Protein denotes microRNA miR34. p53
T7132 13159-13162 Protein denotes p21
T7131 13125-13148 Protein denotes cyclin-dependent kinase
T7130 13062-13065 Protein denotes p53
T7129 13016-13019 Protein denotes p53
T7128 12874-12883 Positive_regulation denotes Activated
T7127 12884-12887 Protein denotes p53
T5454 10877-10886 Protein denotes β-catenin
T5453 10873-10876 Protein denotes Wnt
T5452 10807-10811 Protein denotes WWOX
T5451 10736-10746 Positive_regulation denotes stabilizes
T5450 10674-10683 Binding denotes interacts
T5449 10747-10750 Protein denotes p53
T5448 10648-10662 Protein denotes Activated WWOX
T5447 10552-10557 Binding denotes binds
T5446 10500-10504 Protein denotes WWOX
T5445 10059-10064 Binding denotes binds
T5444 10059-10064 Binding denotes binds
T5443 10059-10064 Binding denotes binds
T5442 10040-10053 Positive_regulation denotes overexpressed
T5441 10040-10053 Gene_expression denotes overexpressed
T5440 10102-10107 Protein denotes c-Jun
T5439 10093-10096 Protein denotes p73
T5438 10087-10091 Protein denotes AP-2
T5437 10054-10058 Protein denotes WWOX
T5436 9837-9845 Binding denotes interact
T5435 9936-9941 Protein denotes RUNX4
T5434 9929-9934 Protein denotes c-Jun
T5433 9921-9927 Protein denotes SIMPLE
T5432 9914-9919 Protein denotes Ezrin
T5431 9907-9912 Protein denotes ErbB4
T5430 9902-9905 Protein denotes p73
T5429 9895-9900 Protein denotes AP-2γ
T5428 9828-9832 Protein denotes WWOX
T5427 9815-9824 Protein denotes WW domain
T5426 9663-9671 Negative_regulation denotes prevents
T5425 9638-9649 Gene_expression denotes Restoration
T5424 9653-9662 Protein denotes WWOX gene
T5423 7422-7433 Binding denotes interacting
T5422 7376-7386 Protein denotes SDR domain
T5421 7300-7304 Protein denotes WWOX
T5420 7137-7140 Protein denotes SDR
T5419 7104-7135 Protein denotes alcohol dehydrogenase/reductase
T5418 7024-7036 Protein denotes WWOX protein
T5417 6888-6908 Protein denotes mouse WWOX/Wwox gene
T5416 6859-6863 Protein denotes WOX1
T5415 6851-6854 Protein denotes FOR
T5414 6845-6849 Protein denotes WWOX
T5413 6799-6834 Protein denotes WW domain-containing oxidoreductase
T5412 6712-6716 Protein denotes WWOX
T5411 6704-6707 Protein denotes p53
T5511 12791-12800 Positive_regulation denotes enhancing
T5510 12668-12673 Binding denotes binds
T5509 12805-12825 Protein denotes SMAD-driven promoter
T5508 12746-12751 Protein denotes Smad4
T5507 12739-12745 Protein denotes Hyal-2
T5506 12734-12738 Protein denotes WWOX
T5505 12638-12667 Protein denotes Transforming growth factor β1
T5504 12547-12554 Binding denotes binding
T5503 12547-12554 Binding denotes binding
T5502 12547-12554 Binding denotes binding
T5501 12547-12554 Binding denotes binding
T5500 12547-12554 Binding denotes binding
T5499 12547-12554 Binding denotes binding
T5498 12547-12554 Binding denotes binding
T5497 12547-12554 Binding denotes binding
T5496 12619-12622 Protein denotes Jin
T5495 12612-12617 Protein denotes Ezrin
T5494 12604-12611 Protein denotes Phospho
T5493 12560-12573 Protein denotes hyaluronidase
T5492 12492-12496 Protein denotes WWOX
T5491 12323-12330 Positive_regulation denotes induces
T5490 12344-12359 Phosphorylation denotes phosphorylation
T5489 12339-12343 Protein denotes WWOX
T5488 12308-12322 Protein denotes Complement C1q
T5487 12253-12262 Localization denotes releasing
T5486 12217-12227 Positive_regulation denotes activation
T5485 12217-12227 Positive_regulation denotes activation
T5484 12146-12156 Gene_expression denotes expression
T5483 12240-12252 Protein denotes cytochrome C
T5482 12204-12214 Protein denotes procaspase
T5481 12187-12199 Protein denotes procaspase-3
T5480 12160-12164 Protein denotes WWOX
T5479 12034-12044 Negative_regulation denotes Inhibition
T5478 12048-12051 Protein denotes MEK
T5477 11924-11931 Positive_regulation denotes induces
T5476 12001-12004 Protein denotes MEK
T5475 11932-11936 Protein denotes WWOX
T5474 11907-11911 Protein denotes WWOX
T5473 11903-11906 Protein denotes MEK
T5472 11807-11812 Binding denotes binds
T5471 11807-11812 Binding denotes binds
T5470 11836-11839 Protein denotes Lin
T5469 11813-11816 Protein denotes MEK
T5468 11527-11530 Protein denotes p53
T5467 11481-11485 Protein denotes WWOX
T5466 11425-11438 Positive_regulation denotes up-regulating
T5465 11368-11383 Negative_regulation denotes down-regulating
T5464 11368-11383 Negative_regulation denotes down-regulating
T5463 11449-11452 Protein denotes p53
T5462 11414-11420 Protein denotes Bcl-xL
T5461 11394-11409 Protein denotes inhibitor Bcl-2
T5460 11343-11364 Protein denotes tumor necrosis factor
T5459 11303-11307 Protein denotes WWOX
T5458 11041-11044 Protein denotes TCF
T5457 10968-10989 Protein denotes WWOX sequesters Dvl-2
T5456 10937-10940 Protein denotes Dvl
T5455 10812-10817 Binding denotes binds
T2314 6524-6529 Protein denotes CD133
T2313 6382-6390 Gene_expression denotes positive
T2312 6376-6381 Protein denotes CD133
T2311 5824-5833 Negative_regulation denotes inhibitor
T2310 5843-5852 Negative_regulation denotes knockdown
T2309 5824-5833 Negative_regulation denotes inhibitor
T2308 5837-5842 Protein denotes STAT3
T2307 5818-5823 Protein denotes STAT3
T2306 5770-5775 Protein denotes NF-κB
T2305 5579-5592 Protein denotes valproic acid
T2304 5639-5643 Protein denotes MGMT
T2303 5594-5597 Protein denotes VAP
T2302 5047-5051 Protein denotes MGMT
T2301 4896-4905 Regulation denotes regulated
T2300 4909-4929 Protein denotes cytochrome c oxidase
T2299 4631-4635 Protein denotes APNG
T2298 4572-4629 Protein denotes base excision repair enzyme alkylpurine-DNA-N-glycosylase
T2297 4487-4500 Protein denotes α5β1 integrin
T2296 4393-4396 Protein denotes p53
T2295 4358-4371 Protein denotes α5β1 integrin
T2294 4070-4077 Negative_regulation denotes reduces
T2293 4070-4077 Negative_regulation denotes reduces
T2292 4070-4077 Negative_regulation denotes reduces
T2291 4098-4107 Protein denotes caspase-3
T2290 4082-4087 Protein denotes Bcl-2
T2289 4078-4081 Protein denotes Bax
T2288 3964-3970 Negative_regulation denotes blocks
T2287 3984-3994 Gene_expression denotes expression
T2286 3914-3922 Positive_regulation denotes increase
T2285 3971-3983 Protein denotes MGMT protein
T2284 3926-3930 Protein denotes MGMT
T2283 3829-3847 Protein denotes MGMT gene promoter
T2282 3528-3532 Negative_regulation denotes loss
T2281 3506-3516 Gene_expression denotes expression
T2280 3520-3524 Protein denotes MGMT
T2279 3300-3310 Positive_regulation denotes activation
T2278 3358-3385 Protein denotes Rad3-related protein kinase
T2277 3260-3264 Protein denotes MGMT
T2276 3158-3162 Protein denotes MGMT
T2275 3118-3156 Protein denotes O6-methylguanine-DNA methyltransferase
T2274 2514-2524 Negative_regulation denotes inhibition
T2273 2528-2547 Protein denotes antiapoptotic Bcl-2
T2272 2051-2063 Protein denotes STAT3 kinase
T2271 1993-2000 Protein denotes histone
T496 1003-1013 Negative_regulation denotes deficiency
T495 988-991 Protein denotes p53
T494 877-885 Regulation denotes modulate
T493 912-916 Protein denotes WWOX
T492 859-862 Protein denotes p53
T491 793-797 Protein denotes WWOX
T490 785-788 Protein denotes p53
T489 693-697 Binding denotes bind
T488 693-697 Binding denotes bind
T487 722-725 Protein denotes p53
T486 665-669 Protein denotes WWOX
T485 553-563 Gene_expression denotes expression
T484 572-581 Protein denotes type WWOX
T483 521-529 Negative_regulation denotes blockade
T482 374-378 Negative_regulation denotes Loss
T481 392-402 Gene_expression denotes expression
T480 382-391 Protein denotes WWOX gene
T479 301-305 Protein denotes WOX1
T478 294-297 Protein denotes FOR
T477 273-292 Protein denotes oxidoreductase WWOX
T476 106-109 Protein denotes p53
R239 T480 T481 themeOf WWOX gene,expression
R240 T481 T482 themeOf expression,Loss
R241 T482 T483 themeOf Loss,blockade
R242 T484 T485 themeOf type WWOX,expression
R243 T486 T488 themeOf WWOX,bind
R244 T486 T489 themeOf WWOX,bind
R245 T487 T489 themeOf p53,bind
R246 T492 T494 causeOf p53,modulate
R247 T493 T494 themeOf WWOX,modulate
R248 T495 T496 themeOf p53,deficiency
R1526 T2273 T2274 themeOf antiapoptotic Bcl-2,inhibition
R1529 T2278 T2279 themeOf Rad3-related protein kinase,activation
R1530 T2280 T2281 themeOf MGMT,expression
R1532 T2281 T2282 themeOf expression,loss
R1533 T2284 T2286 themeOf MGMT,increase
R1534 T2285 T2287 themeOf MGMT protein,expression
R1537 T2287 T2288 themeOf expression,blocks
R1538 T2289 T2292 themeOf Bax,reduces
R1540 T2290 T2293 themeOf Bcl-2,reduces
R1541 T2291 T2294 themeOf caspase-3,reduces
R1544 T2300 T2301 themeOf cytochrome c oxidase,regulated
R1546 T2307 T2309 themeOf STAT3,inhibitor
R1547 T2308 T2310 themeOf STAT3,knockdown
R1548 T2310 T2311 themeOf knockdown,inhibitor
R1549 T2312 T2313 themeOf CD133,positive
R3757 T5422 T5423 themeOf SDR domain,interacting
R3767 T5424 T5425 themeOf WWOX gene,Restoration
R3768 T5425 T5426 themeOf Restoration,prevents
R3770 T5428 T5436 themeOf WWOX,interact
R3771 T5435 T5436 themeOf RUNX4,interact
R3772 T5437 T5441 themeOf WWOX,overexpressed
R3773 T5437 T5443 themeOf WWOX,binds
R3774 T5437 T5444 themeOf WWOX,binds
R3775 T5437 T5445 themeOf WWOX,binds
R3776 T5439 T5444 themeOf p73,binds
R3777 T5440 T5445 themeOf c-Jun,binds
R3778 T5441 T5442 themeOf overexpressed,overexpressed
R3780 T5446 T5447 themeOf WWOX,binds
R3782 T5448 T5450 themeOf Activated WWOX,interacts
R3783 T5449 T5451 themeOf p53,stabilizes
R3785 T5452 T5455 themeOf WWOX,binds
R3787 T5461 T5464 themeOf inhibitor Bcl-2,down-regulating
R3788 T5462 T5465 themeOf Bcl-xL,down-regulating
R3789 T5463 T5466 themeOf p53,up-regulating
R3792 T5469 T5471 themeOf MEK,binds
R3793 T5469 T5472 themeOf MEK,binds
R3794 T5470 T5472 themeOf Lin,binds
R3797 T5475 T5477 themeOf WWOX,induces
R3800 T5478 T5479 themeOf MEK,Inhibition
R3801 T5480 T5484 themeOf WWOX,expression
R3802 T5481 T5485 themeOf procaspase-3,activation
R3803 T5482 T5486 themeOf procaspase,activation
R3804 T5483 T5487 themeOf cytochrome C,releasing
R3807 T5488 T5491 causeOf Complement C1q,induces
R3808 T5489 T5490 themeOf WWOX,phosphorylation
R3810 T5490 T5491 themeOf phosphorylation,induces
R3811 T5492 T5497 themeOf WWOX,binding
R3812 T5492 T5500 themeOf WWOX,binding
R3813 T5492 T5501 themeOf WWOX,binding
R3814 T5492 T5502 themeOf WWOX,binding
R3815 T5492 T5503 themeOf WWOX,binding
R3816 T5492 T5504 themeOf WWOX,binding
R3817 T5493 T5498 themeOf hyaluronidase,binding
R3818 T5493 T5500 themeOf hyaluronidase,binding
R3819 T5493 T5504 themeOf hyaluronidase,binding
R3820 T5494 T5501 themeOf Phospho,binding
R3821 T5495 T5502 themeOf Ezrin,binding
R3822 T5496 T5499 themeOf Jin,binding
R3823 T5496 T5503 themeOf Jin,binding
R3824 T5496 T5504 themeOf Jin,binding
R3826 T5505 T5510 themeOf Transforming growth factor β1,binds
R3829 T5509 T5511 themeOf SMAD-driven promoter,enhancing
R4987 T7127 T7128 themeOf p53,Activated
R4988 T7135 T7136 themeOf antiapoptotic gene BCL-2,inhibiting
R4989 T7138 T7151 causeOf p53,controlling
R4990 T7138 T7152 causeOf p53,controlling
R4991 T7138 T7153 causeOf p53,controlling
R4992 T7138 T7154 causeOf p53,controlling
R4993 T7139 T7143 themeOf smooth muscle α-actin,expression
R4994 T7140 T7144 themeOf collagens IIα1,expression
R4995 T7141 T7145 themeOf VIα1,expression
R4996 T7142 T7146 themeOf Sun,expression
R4997 T7143 T7147 themeOf expression,regulating
R4998 T7144 T7148 themeOf expression,regulating
R4999 T7145 T7149 themeOf expression,regulating
R5000 T7146 T7150 themeOf expression,regulating
R5001 T7147 T7151 themeOf regulating,controlling
R5002 T7148 T7152 themeOf regulating,controlling
R5003 T7149 T7153 themeOf regulating,controlling
R5004 T7150 T7154 themeOf regulating,controlling
R5495 T7945 T7946 themeOf p53 isoforms,expression
R5496 T7947 T7950 themeOf "Full-length p53, Δ133p53",localized
R5497 T7948 T7951 themeOf p53β,localized
R5498 T7949 T7950 locationOf nucleus,localized
R5499 T7949 T7951 locationOf nucleus,localized
R5500 T7952 T7956 themeOf p53γ,localized
R5501 T7952 T7958 themeOf p53γ,localized
R5502 T7953 T7957 themeOf Δ133p53β,localized
R5503 T7953 T7959 themeOf Δ133p53β,localized
R5504 T7954 T7956 locationOf nucleus,localized
R5505 T7954 T7957 locationOf nucleus,localized
R5506 T7955 T7958 locationOf cytoplasm,localized
R5507 T7955 T7959 locationOf cytoplasm,localized
R5508 T7960 T7961 themeOf Δ133p53γ,localized
R5509 T7962 T7968 themeOf p53,Co-transfection
R5510 T7963 T7969 themeOf p53β,Co-transfection
R5511 T7965 T7976 themeOf p53,co-expression
R5512 T7966 T7977 themeOf Δ133p53,co-expression
R5513 T7968 T7970 themeOf Co-transfection,Co-transfection
R5514 T7968 T7972 themeOf Co-transfection,increases
R5515 T7968 T7974 themeOf Co-transfection,increases
R5516 T7969 T7971 themeOf Co-transfection,Co-transfection
R5517 T7969 T7973 themeOf Co-transfection,increases
R5518 T7969 T7975 themeOf Co-transfection,increases
R5519 T7970 T7972 causeOf Co-transfection,increases
R5520 T7970 T7973 causeOf Co-transfection,increases
R5521 T7971 T7974 causeOf Co-transfection,increases
R5522 T7971 T7975 causeOf Co-transfection,increases
R5523 T7980 T7985 themeOf Δ133p53β,Co-expression
R5524 T7981 T7986 themeOf p53,Co-expression
R5525 T7985 T7987 themeOf Co-expression,affect
R5526 T7986 T7988 themeOf Co-expression,affect
R6206 T9062 T9064 themeOf p53,Loss
R6207 T9066 T9068 themeOf WWOX,expression
R6208 T9067 T9069 themeOf WWOX,downregulation
R6209 T9068 T9070 themeOf expression,Altered
R6210 T9073 T9074 themeOf p53,expressing
R6211 T9078 T9080 themeOf WWOX,Activated
R6212 T9078 T9081 themeOf WWOX,binds
R6213 T9079 T9082 themeOf p53,phosphorylation
R6214 T9083 T9084 themeOf WWOX,binding
R6215 T9087 T9089 themeOf Mutant p53 proteins,bind
R6216 T9090 T9091 themeOf p53 isoforms,expressing
R7713 T11329 T11331 themeOf WWOX,Binding
R7714 T11329 T11333 themeOf WWOX,Binding
R7715 T11330 T11332 themeOf p53,Binding
R7716 T11330 T11333 themeOf p53,Binding
R7717 T11334 T11337 themeOf WWOX,binds
R7718 T11334 T11339 themeOf WWOX,binds
R7719 T11335 T11338 themeOf MEK,binds
R7720 T11335 T11339 themeOf MEK,binds
R7721 T11342 T11343 themeOf MEK,inhibition
R7722 T11345 T11346 themeOf WWOX,activated
R7723 T11349 T11351 themeOf p53,interacts
R7724 T11350 T11351 themeOf WWOX,interacts
R7725 T11355 T11360 themeOf p53,upregulated
R7726 T11356 T11361 themeOf WWOX,upregulated
R7727 T11357 T11362 themeOf Smad4,upregulated
R7728 T11358 T11363 themeOf PTEN,upregulated
R7729 T11359 T11364 themeOf PP2A,upregulated
R7730 T11365 T11366 themeOf function of endogenous p53,counteracts
R7731 T11371 T11374 themeOf CD44,possess
R7732 T11371 T11377 themeOf CD44,interacting
R7733 T11371 T11378 themeOf CD44,interacting
R7734 T11372 T11375 themeOf secrete hyaluronidases,possess
R7735 T11372 T11377 themeOf secrete hyaluronidases,interacting
R7736 T11373 T11376 themeOf metalloproteinases,possess
R7737 T11373 T11378 themeOf metalloproteinases,interacting
R7738 T11379 T11380 themeOf WWOX,expression
R7739 T11380 T11381 themeOf expression,lack
R7740 T11382 T11386 themeOf TIAF1,expression
R7741 T11384 T11387 themeOf p53,expression
R7742 T11385 T11388 themeOf WWOX,expression
R7743 T11390 T11391 themeOf WWOX,negative
R7744 T11392 T11393 themeOf WWOX,expressing
R7745 T11394 T11396 themeOf Wwox gene,expression
R7746 T11395 T11397 themeOf ROS,production
R7747 T11402 T11403 themeOf WWOX,deficiency
R9353 T13503 T13506 themeOf WWOX,phosphorylated
R9354 T13503 T13508 themeOf WWOX,binds
R9355 T13504 T13507 themeOf Tyr33,phosphorylated
R9356 T13505 T13508 themeOf p53,binds
R9357 T13511 T13514 themeOf RUNX2,binds
R9358 T13511 T13517 themeOf RUNX2,binding
R9359 T13512 T13515 themeOf c-Jun,binds
R9360 T13512 T13518 themeOf c-Jun,binding
R9361 T13513 T13516 themeOf ERBB4,binds
R9362 T13513 T13519 themeOf ERBB4,binding
R9363 T13517 T13520 themeOf binding,blocks
R9364 T13518 T13521 themeOf binding,blocks
R9365 T13519 T13522 themeOf binding,blocks
R9366 T13523 T13526 themeOf Tau,binds
R9367 T13524 T13526 themeOf SDR,binds
R9368 T13524 T13525 partOf SDR,domain
R9369 T13525 T13526 Site domain,binds
R9370 T13527 T13531 themeOf WWOX,binding
R9371 T13530 T13531 themeOf Dvl,binding
R9372 T13535 T13538 themeOf WWOX,recruited
R9373 T13536 T13539 themeOf Hyal-2,association
R9374 T13537 T13540 themeOf phospho-Ezrin,association
R9375 T13542 T13545 themeOf TGF-β1,binds
R9376 T13543 T13545 themeOf WWOX,binds
R9377 T13543 T13546 themeOf WWOX,complex
R9378 T13544 T13547 themeOf SMAD-driven promoter,enhancing
R9945 T14512 T14513 themeOf endogenous wild type p53,expressing
R9946 T14514 T14516 themeOf WWOX,binds
R9947 T14517 T14519 themeOf mutant p53 proteins,interactions
R9948 T14518 T14519 themeOf WWOX,interactions
R9949 T14520 T14521 themeOf p53,expressing
R9950 T14523 T14524 themeOf p53 isoforms,expressing

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T552 0-5 NNP denotes Tumor
T553 6-16 NNP denotes Suppressor
T554 17-21 NNP denotes WWOX
T555 22-25 CC denotes and
T556 26-29 NN denotes p53
T557 30-41 NNS denotes Alterations
T558 42-45 CC denotes and
T559 46-50 NN denotes Drug
T560 51-61 NN denotes Resistance
T561 62-64 IN denotes in
T562 65-78 NNP denotes Glioblastomas
T12994 9217-9219 NN denotes A.
T14722 14832-14833 . denotes .
T14721 14826-14832 NN denotes region
T14720 14820-14825 JJ denotes basic
T14719 14818-14819 , denotes ,
T14718 14816-14818 NNP denotes BR
T14717 14814-14815 : denotes ;
T14716 14808-14814 NN denotes domain
T14715 14792-14807 NN denotes oligomerization
T14714 14790-14791 , denotes ,
T14713 14788-14790 NNP denotes OD
T14712 14786-14787 : denotes ;
T14711 14780-14786 NN denotes signal
T14710 14767-14779 NN denotes localization
T14709 14759-14766 JJ denotes nuclear
T14708 14757-14758 , denotes ,
T14707 14754-14757 NNP denotes NLS
T14706 14752-14753 : denotes ;
T14705 14746-14752 NN denotes domain
T14704 14738-14745 NN denotes proline
T14703 14736-14737 , denotes ,
T14702 14733-14736 NNP denotes PrD
T14701 14731-14732 : denotes ;
T14700 14725-14731 NN denotes domain
T14699 14709-14724 NN denotes transactivation
T14698 14707-14708 , denotes ,
T14697 14704-14707 NN denotes TAD
T14696 14702-14703 . denotes .
T14695 14691-14702 VBN denotes established
T14694 14688-14690 VB denotes be
T14693 14685-14687 TO denotes to
T14692 14677-14684 VBZ denotes remains
T14691 14668-14676 NNS denotes isoforms
T14690 14664-14667 NN denotes p53
T14689 14653-14663 VBG denotes expressing
T14688 14647-14652 NNS denotes cells
T14687 14643-14646 NNP denotes GBM
T14686 14640-14642 IN denotes in
T14685 14630-14639 NN denotes apoptosis
T14684 14627-14629 IN denotes of
T14683 14617-14626 NN denotes induction
T14682 14612-14616 NNP denotes WWOX
T14681 14604-14611 JJ denotes ectopic
T14680 14596-14603 IN denotes whether
T14679 14594-14595 , denotes ,
T14678 14590-14594 RB denotes Also
T14677 14588-14589 . denotes .
T14676 14581-14588 JJ denotes unknown
T14675 14578-14580 VBZ denotes is
T14674 14569-14577 NNS denotes isoforms
T14673 14565-14568 NN denotes p53
T14672 14559-14564 VBZ denotes binds
T14671 14554-14558 NNP denotes WWOX
T14670 14546-14553 IN denotes whether
T14669 14544-14545 , denotes ,
T14668 14537-14544 RB denotes Finally
T14667 14535-14536 . denotes .
T14666 14530-14535 NNS denotes cells
T14665 14515-14529 JJ denotes p53-expressing
T14664 14508-14514 JJ denotes mutant
T14663 14505-14507 IN denotes in
T14662 14495-14504 NN denotes apoptosis
T14661 14488-14494 VB denotes induce
T14660 14483-14487 NNP denotes WWOX
T14659 14475-14482 JJ denotes ectopic
T14658 14473-14474 , denotes ,
T14657 14469-14473 RB denotes Thus
T14656 14467-14468 . denotes .
T14655 14462-14467 NNS denotes cells
T14654 14458-14461 NNP denotes GBM
T14653 14455-14457 IN denotes in
T14652 14446-14454 VBN denotes expected
T14651 14442-14445 VBP denotes are
T14650 14437-14441 NNP denotes WWOX
T14649 14433-14436 CC denotes and
T14648 14424-14432 NNS denotes proteins
T14647 14420-14423 NN denotes p53
T14646 14413-14419 JJ denotes mutant
T14645 14405-14412 IN denotes between
T14644 14392-14404 NNS denotes interactions
T14643 14383-14391 JJ denotes physical
T14642 14380-14382 DT denotes no
T14641 14378-14379 , denotes ,
T14640 14372-14378 NNP denotes Second
T14639 14370-14371 . denotes .
T14638 14361-14370 NN denotes apoptosis
T14637 14352-14360 VBG denotes inducing
T14636 14349-14351 IN denotes in
T14635 14340-14348 NN denotes function
T14634 14332-14337 JJ denotes other
T14633 14327-14331 DT denotes each
T14632 14319-14326 VBP denotes nullify
T14631 14310-14318 NNS denotes proteins
T14630 14305-14309 DT denotes both
T14629 14301-14304 CC denotes and
T14628 14299-14300 , denotes ,
T14627 14296-14299 NN denotes p53
T14626 14284-14295 NNS denotes antagonizes
T14625 14271-14283 RB denotes functionally
T14624 14267-14270 CC denotes and
T14623 14261-14266 NNS denotes binds
T14622 14256-14260 NNP denotes WWOX
T14621 14248-14255 JJ denotes ectopic
T14620 14243-14247 IN denotes that
T14619 14235-14242 VBZ denotes appears
T14618 14232-14234 PRP denotes It
T14617 14230-14231 . denotes .
T14616 14227-14230 NN denotes p53
T14615 14222-14226 NN denotes type
T14614 14217-14221 JJ denotes wild
T14613 14206-14216 JJ denotes endogenous
T14612 14195-14205 VBG denotes expressing
T14611 14189-14194 NNS denotes cells
T14610 14185-14188 NNP denotes GBM
T14609 14182-14184 IN denotes of
T14608 14172-14181 NN denotes apoptosis
T14607 14165-14171 VB denotes induce
T14606 14162-14164 TO denotes to
T14605 14156-14161 VBZ denotes fails
T14604 14151-14155 NNP denotes WWOX
T14603 14143-14150 JJ denotes ectopic
T14602 14141-14142 , denotes ,
T14601 14136-14141 RB denotes First
T14600 14134-14135 . denotes .
T14599 14129-14134 NN denotes death
T14598 14124-14128 NN denotes cell
T14597 14120-14123 NNP denotes GBM
T14596 14111-14119 VB denotes regulate
T14595 14108-14110 TO denotes to
T14594 14104-14107 NN denotes p53
T14593 14100-14103 CC denotes and
T14592 14095-14099 NNP denotes WWOX
T14591 14091-14094 IN denotes for
T14590 14082-14090 VBN denotes proposed
T14589 14078-14081 VBP denotes are
T14588 14068-14077 NNS denotes scenarios
T14587 14061-14067 JJ denotes likely
T14586 14055-14060 CD denotes Three
T14585 14053-14054 -RRB- denotes )
T14584 14052-14053 NNP denotes B
T14583 14051-14052 -LRB- denotes (
T14582 14049-14050 . denotes .
T14581 14044-14049 VBN denotes shown
T14580 14039-14043 RB denotes also
T14579 14035-14038 VBP denotes are
T14578 14031-14034 NN denotes p53
T14577 14028-14030 IN denotes of
T14576 14020-14027 NNS denotes mutants
T14575 14011-14019 NN denotes deletion
T14574 14000-14010 JJ denotes N-terminal
T14573 13998-13999 . denotes .
T14572 13992-13998 NN denotes region
T14571 13986-13991 JJ denotes basic
T14570 13984-13985 DT denotes a
T14569 13980-13983 CC denotes and
T14568 13978-13979 , denotes ,
T14567 13972-13978 NN denotes domain
T14566 13956-13971 NN denotes oligomerization
T14565 13953-13955 DT denotes an
T14564 13951-13952 , denotes ,
T14563 13945-13951 NN denotes signal
T14562 13932-13944 NN denotes localization
T14561 13924-13931 JJ denotes nuclear
T14560 13922-13923 DT denotes a
T14559 13911-13921 VBG denotes containing
T14558 13909-13910 , denotes ,
T14557 13903-13909 NN denotes domain
T14556 13892-13902 JJ denotes C-terminal
T14555 13890-13891 DT denotes a
T14554 13886-13889 CC denotes and
T14553 13884-13885 , denotes ,
T14552 13878-13884 NN denotes region
T14551 13866-13877 JJ denotes DNA-binding
T14550 13858-13865 JJ denotes central
T14549 13856-13857 DT denotes a
T14548 13854-13855 , denotes ,
T14547 13848-13854 NN denotes domain
T14540 13790-13800 JJ denotes N-terminal
T14539 13786-13789 CD denotes two
T14538 13776-13785 VBZ denotes possesses
T14537 13772-13775 NN denotes p53
T14536 13760-13771 JJ denotes Full-length
T14535 13758-13759 -RRB- denotes )
T14534 13757-13758 NNP denotes A
T14533 13756-13757 -LRB- denotes (
T14532 13754-13755 . denotes .
T14531 13745-13754 NN denotes apoptosis
T14530 13740-13744 NN denotes cell
T14529 13736-13739 NNP denotes GBM
T14528 13733-13735 IN denotes in
T14527 13728-13732 NNP denotes WWOX
T14526 13724-13727 CC denotes and
T14525 13720-13723 NN denotes p53
T14546 13835-13847 JJ denotes proline-rich
T14545 13833-13834 DT denotes a
T14544 13831-13832 , denotes ,
T14543 13824-13831 NNS denotes domains
T14542 13817-13823 JJ denotes acidic
T14541 13801-13816 NN denotes transactivation
T13964 8910-8916 NN denotes TGF-β1
T13963 8906-8909 IN denotes for
T13962 8897-8905 NN denotes receptor
T13961 8885-8896 NN denotes alternative
T13960 8882-8884 DT denotes an
T13959 8879-8881 VBZ denotes is
T13958 8872-8878 NN denotes Hyal-2
T13957 8870-8871 . denotes .
T13956 8857-8870 JJ denotes phospho-Ezrin
T13955 8853-8856 CC denotes and
T13954 8846-8852 JJ denotes Hyal-2
T13953 8841-8845 IN denotes with
T13952 8829-8840 NN denotes association
T13951 8826-8828 IN denotes by
T13950 8821-8825 NN denotes area
T13949 8812-8820 NN denotes membrane
T13948 8808-8811 DT denotes the
T13947 8805-8807 TO denotes to
T13946 8795-8804 VBN denotes recruited
T13945 8792-8794 VBZ denotes is
T13944 8787-8791 NNP denotes WWOX
T13943 8785-8786 . denotes .
T13942 8780-8785 NN denotes death
T13941 8775-8779 NN denotes cell
T13940 8767-8774 VBG denotes causing
T13939 8763-8766 IN denotes for
T13938 8750-8762 NN denotes mitochondria
T13937 8746-8749 DT denotes the
T13936 8743-8745 TO denotes to
T13935 8730-8742 VBZ denotes translocates
T13934 8725-8729 NNP denotes WWOX
T13933 8716-8724 VBN denotes released
T13932 8712-8715 DT denotes the
T13931 8708-8711 CC denotes and
T13930 8706-8707 , denotes ,
T13929 8702-8706 NN denotes cell
T13928 8700-8701 NNP denotes T
T13927 8693-8699 NNP denotes Jurkat
T13926 8690-8692 IN denotes in
T13925 8682-8689 NN denotes complex
T13924 8673-8681 NNP denotes MEK/WWOX
T13923 8670-8672 IN denotes of
T13922 8657-8669 NN denotes dissociation
T13921 8653-8656 DT denotes the
T13920 8642-8652 VBZ denotes stimulates
T13919 8636-8641 NN denotes ester
T13918 8628-8635 NNP denotes Phorbol
T13917 8626-8627 . denotes .
T13916 8620-8626 NN denotes import
T13915 8612-8619 JJ denotes nuclear
T13914 8608-8611 PRP$ denotes its
T13913 8597-8607 VBG denotes inhibiting
T13912 8593-8596 CC denotes and
T13911 8589-8592 NNP denotes Dvl
T13910 8581-8588 JJ denotes binding
T13909 8578-8580 IN denotes by
T13908 8570-8577 NN denotes pathway
T13907 8563-8569 NN denotes signal
T13906 8553-8562 JJ denotes β-catenin
T13905 8552-8553 NNP denotes /
T13904 8549-8552 NNP denotes Wnt
T13903 8545-8548 DT denotes the
T13902 8542-8544 IN denotes in
T13901 8529-8541 VBZ denotes participates
T13900 8524-8528 NNP denotes WWOX
T13899 8522-8523 . denotes .
T13898 8516-8522 NN denotes domain
T13897 8512-8515 NNP denotes SDR
T13896 8508-8511 PRP$ denotes its
T13895 8504-8507 IN denotes via
T13894 8500-8503 NNP denotes Tau
T13893 8494-8499 VBZ denotes binds
T13892 8489-8493 NNP denotes WWOX
T13891 8487-8488 . denotes .
T13890 8478-8487 NN denotes cytoplasm
T13889 8474-8477 DT denotes the
T13888 8471-8473 IN denotes in
T13887 8466-8470 PRP denotes them
T13886 8456-8465 VBG denotes retaining
T13885 8453-8455 IN denotes by
T13884 8444-8452 NNS denotes proteins
T13883 8438-8443 DT denotes these
T13882 8435-8437 IN denotes of
T13881 8426-8434 NN denotes activity
T13880 8422-8425 DT denotes the
T13879 8415-8421 NNS denotes blocks
T13878 8407-8414 JJ denotes binding
T13877 8403-8406 DT denotes the
T13876 8399-8402 CC denotes and
T13875 8397-8398 , denotes ,
T13874 8391-8397 NN denotes domain
T13873 8388-8390 NNP denotes WW
T13871 8378-8381 PRP$ denotes its
T13870 8374-8377 IN denotes via
T13869 8372-8373 , denotes ,
T13868 8367-8372 NNP denotes ERBB4
T13867 8363-8366 CC denotes and
T13866 8361-8362 , denotes ,
T13865 8356-8361 NNP denotes c-Jun
T13864 8354-8355 , denotes ,
T13863 8349-8354 NNP denotes RUNX2
T13862 8346-8348 IN denotes as
T13861 8341-8345 JJ denotes such
T13860 8339-8340 , denotes ,
T13859 8332-8339 NNS denotes factors
T13858 8318-8331 NN denotes transcription
T13857 8301-8317 NN denotes motif-containing
T13856 8296-8300 NNP denotes PPxY
T13855 8290-8295 VBZ denotes binds
T13854 8285-8289 RB denotes also
T13853 8280-8284 NNP denotes WWOX
T13852 8278-8279 . denotes .
T13851 8269-8278 NN denotes apoptosis
T13850 8262-8268 VB denotes induce
T13849 8259-8261 TO denotes to
T13848 8251-8258 NN denotes nucleus
T13626 7842-7844 FW denotes et
T13625 7839-7841 NNP denotes Su
T13624 7837-7838 : denotes ;
T13623 7833-7837 CD denotes 2012
T13622 7831-7832 , denotes ,
T13621 7828-7831 FW denotes al.
T13620 7825-7827 FW denotes et
T13619 7819-7824 NNP denotes Salah
T13618 7817-7818 : denotes ;
T13617 7813-7817 CD denotes 2011
T13616 7811-7812 , denotes ,
T13615 7808-7811 FW denotes al.
T13614 7805-7807 FW denotes et
T13613 7800-7804 NNP denotes Mare
T13612 7796-7799 NNP denotes Del
T13611 7794-7795 : denotes ;
T13610 7790-7794 CD denotes 2007
T13609 7788-7789 , denotes ,
T13608 7784-7788 CD denotes 2003
T13607 7782-7783 , denotes ,
T13606 7779-7782 FW denotes al.
T13605 7776-7778 FW denotes et
T13604 7770-7775 NNP denotes Chang
T13603 7769-7770 -LRB- denotes (
T13602 7761-7768 NNS denotes domains
T13601 7758-7760 NNP denotes WW
T13600 7754-7757 DT denotes the
T13599 7746-7753 IN denotes between
T13598 7743-7745 IN denotes in
T13597 7740-7742 VBZ denotes is
T13596 7738-7739 -RRB- denotes )
T13595 7735-7738 NNP denotes NLS
T13594 7734-7735 -LRB- denotes (
T13593 7727-7733 NN denotes signal
T13592 7714-7726 NN denotes localization
T13591 7706-7713 JJ denotes nuclear
T13590 7704-7705 DT denotes A
T13589 7702-7703 . denotes .
T13588 7696-7702 NN denotes region
T13587 7693-7695 JJ denotes D3
T13586 7691-7692 DT denotes a
T13585 7687-7690 CC denotes and
T13584 7685-7686 , denotes ,
T13583 7679-7685 NN denotes domain
T13582 7677-7678 -RRB- denotes )
T13581 7674-7677 NNP denotes SDR
T13580 7673-7674 -LRB- denotes (
T13579 7649-7672 NN denotes dehydrogenase/reductase
T13578 7641-7648 NN denotes alcohol
T13577 7629-7640 NN denotes short-chain
T13576 7618-7628 JJ denotes C-terminal
T13575 7616-7617 DT denotes a
T13574 7614-7615 , denotes ,
T13573 7607-7614 NNS denotes domains
T13572 7604-7606 NNP denotes WW
T13571 7593-7603 JJ denotes N-terminal
T13570 7589-7592 CD denotes two
T13569 7580-7588 VBZ denotes contains
T13568 7575-7579 NNP denotes WWOX
T13567 7573-7574 . denotes .
T13566 7564-7573 VBG denotes signaling
T13565 7561-7563 IN denotes in
T13564 7556-7560 NN denotes role
T13563 7552-7555 PRP$ denotes its
T13562 7548-7551 CC denotes and
T13561 7538-7547 NN denotes structure
T13560 7533-7537 NNP denotes WWOX
T13559 7530-7532 IN denotes of
T13558 7521-7529 NNS denotes diagrams
T13557 7511-7520 JJ denotes Schematic
T13847 8248-8250 CC denotes or
T13846 8235-8247 VB denotes mitochondria
T13845 8232-8234 TO denotes to
T13844 8219-8231 VBZ denotes translocates
T13843 8214-8218 RB denotes then
T13842 8206-8213 JJ denotes complex
T13841 8197-8205 JJ denotes WWOX/p53
T13840 8193-8196 DT denotes The
T13839 8191-8192 . denotes .
T13838 8188-8191 NN denotes p53
T13837 8182-8187 VBZ denotes binds
T13836 8178-8181 CC denotes and
T13835 8172-8177 CD denotes Tyr33
T13834 8169-8171 IN denotes in
T13833 8154-8168 VBN denotes phosphorylated
T13832 8151-8153 VBZ denotes is
T13831 8146-8150 NNP denotes WWOX
T13830 8144-8145 , denotes ,
T13829 8133-8144 NN denotes stimulation
T13828 8126-8132 NN denotes stress
T13827 8121-8125 IN denotes Upon
T13826 8119-8120 . denotes .
T13825 8107-8119 RB denotes respectively
T13824 8105-8106 , denotes ,
T13823 8099-8105 NNP denotes Thr3B3
T13822 8095-8098 CC denotes and
T13821 8093-8094 , denotes ,
T13820 8087-8093 NNP denotes Tyr293
T13819 8085-8086 , denotes ,
T13818 8080-8085 NNP denotes Tyr61
T13817 8078-8079 , denotes ,
T13816 8073-8078 NNP denotes Ser14
T13815 8071-8072 , denotes ,
T13814 8066-8071 NNP denotes Thr12
T13813 8064-8065 , denotes ,
T13812 8060-8064 NNP denotes Tyr6
T13811 8056-8059 VBP denotes are
T13810 8049-8055 NNP denotes Server
T13809 8045-8048 CD denotes 2.0
T13808 8037-8044 NNP denotes NetPhos
T13807 8034-8036 IN denotes by
T13806 8024-8033 VBN denotes predicted
T13805 8018-8023 NNS denotes sites
T13804 8002-8017 NN denotes phosphorylation
T13803 7996-8001 JJ denotes Other
T13802 7994-7995 . denotes .
T13801 7988-7994 NNP denotes Tyr287
T13800 7984-7987 CC denotes and
T13799 7978-7983 NNP denotes Tyr33
T13798 7976-7977 , denotes ,
T13797 7971-7976 NNS denotes sites
T13796 7955-7970 NN denotes phosphorylation
T13795 7946-7954 NN denotes tyrosine
T13794 7936-7945 JJ denotes conserved
T13793 7932-7935 CD denotes two
T13792 7928-7931 VBP denotes are
T13791 7922-7927 EX denotes There
T13790 7920-7921 . denotes .
T13789 7914-7920 NN denotes region
T13788 7893-7913 JJ denotes mitochondria-binding
T13787 7891-7892 DT denotes a
T13786 7881-7890 VBZ denotes possesses
T13785 7874-7880 NN denotes domain
T13784 7870-7873 NNP denotes SDR
T13783 7866-7869 DT denotes The
T13782 7864-7865 . denotes .
T13781 7863-7864 -RRB- denotes )
T13780 7856-7863 NNS denotes reviews
T13779 7854-7855 : denotes ;
T13778 7850-7854 CD denotes 2012
T13777 7848-7849 , denotes ,
T13776 7845-7848 FW denotes al.
T12993 9210-9216 NN denotes kinase
T12992 9202-9209 NN denotes protein
T12991 9200-9201 , denotes ,
T12990 9197-9200 NNP denotes PKA
T12989 9195-9196 : denotes ;
T12988 9189-9195 NN denotes kinase
T12987 9180-9188 NN denotes synthase
T12986 9171-9179 NN denotes glycogen
T12985 9169-9170 , denotes ,
T12984 9166-9169 NNP denotes GSK
T12983 9164-9165 : denotes ;
T12982 9158-9164 NN denotes kinase
T12981 9151-9157 NN denotes casein
T12980 9149-9150 , denotes ,
T12979 9146-9149 NNP denotes CKI
T12978 9144-9145 : denotes ;
T12977 9143-9144 CD denotes 2
T12976 9118-9142 NN denotes hyaluronoglucosaminidase
T12975 9116-9117 , denotes ,
T12974 9110-9116 NNP denotes Hyal-2
T12973 9108-9109 : denotes ;
T12972 9107-9108 CD denotes 1
T12971 9100-9106 NN denotes kinase
T12970 9083-9099 JJ denotes Cdc42-associated
T12969 9073-9082 VBN denotes activated
T12968 9071-9072 , denotes ,
T12645 23149-23150 . denotes .
T12644 23141-23149 NN denotes interest
T12643 23138-23140 IN denotes of
T12642 23129-23137 NN denotes conflict
T12641 23119-23128 JJ denotes potential
T12640 23117-23118 DT denotes a
T12639 23114-23116 IN denotes as
T12638 23104-23113 VBN denotes construed
T12637 23101-23103 VB denotes be
T12636 23095-23100 MD denotes could
T12635 23090-23094 WDT denotes that
T12634 23076-23089 NNS denotes relationships
T12633 23066-23075 JJ denotes financial
T12632 23063-23065 CC denotes or
T12631 23052-23062 JJ denotes commercial
T12630 23048-23051 DT denotes any
T12629 23045-23047 IN denotes of
T12628 23037-23044 NN denotes absence
T12627 23033-23036 DT denotes the
T12626 23030-23032 IN denotes in
T12625 23020-23029 VBN denotes conducted
T12624 23016-23019 VBD denotes was
T12623 23007-23015 NN denotes research
T12622 23003-23006 DT denotes the
T12621 22998-23002 IN denotes that
T12620 22990-22997 VBP denotes declare
T12619 22982-22989 NNS denotes authors
T12618 22978-22981 DT denotes The
T12967 9067-9071 NNP denotes Ack1
T12966 9065-9066 . denotes .
T12965 9057-9065 NN denotes activity
T12964 9048-9056 NN denotes promoter
T12963 9036-9047 JJ denotes SMAD-driven
T12962 9032-9035 DT denotes the
T12961 9022-9031 VBG denotes enhancing
T12960 9018-9021 CC denotes and
T12959 9010-9017 NN denotes nucleus
T12958 9006-9009 DT denotes the
T12957 9003-9005 TO denotes to
T12587 22944-22945 . denotes .
T12586 22935-22944 NNS denotes coauthors
T12585 22930-22934 IN denotes with
T12584 22920-22929 VBN denotes discussed
T12583 22916-22919 CC denotes and
T12582 22914-22915 , denotes ,
T12581 22904-22914 NN denotes manuscript
T12580 22900-22903 DT denotes the
T12579 22892-22899 VBD denotes revised
T12578 22881-22891 RB denotes thoroughly
T12577 22877-22880 CC denotes and
T12576 22871-22876 VBD denotes wrote
T12575 22869-22870 , denotes ,
T12574 22864-22869 NNS denotes ideas
T12573 22854-22863 VBD denotes conceived
T12572 22848-22853 NNP denotes Chang
T12571 22839-22847 NNP denotes Nan-Shan
T12570 22837-22838 : denotes ;
T12569 22828-22837 NNS denotes citations
T12568 22820-22827 VBD denotes managed
T12567 22815-22819 NNP denotes Wang
T12566 22807-22814 NNP denotes Wan-Jen
T12565 22805-22806 : denotes ;
T12564 22799-22805 NNS denotes graphs
T12563 22790-22798 VBN denotes designed
T12562 22786-22789 CC denotes and
T12561 22781-22785 NNP denotes WWOX
T12560 22777-22780 CC denotes and
T12559 22773-22776 NN denotes p53
T12558 22769-22772 IN denotes for
T12557 22760-22768 NNS denotes sections
T12556 22753-22759 NN denotes review
T12555 22749-22752 DT denotes the
T12554 22743-22748 VBD denotes wrote
T12553 22738-22742 NNP denotes Chou
T12552 22731-22737 NNP denotes Pei-Yi
T12551 22729-22730 : denotes ;
T12550 22726-22729 NNP denotes TMZ
T12549 22721-22725 IN denotes with
T12548 22713-22720 VBG denotes dealing
T12547 22704-22712 NNS denotes sections
T12546 22700-22703 DT denotes the
T12545 22694-22699 VBD denotes wrote
T12544 22690-22693 NNP denotes Sze
T12543 22683-22689 NNP denotes Chun-I
T12542 22679-22682 CC denotes and
T12541 22672-22678 NNP denotes Chiang
T12540 22664-22671 NNP denotes Ming-Fu
T12412 22640-22641 . denotes .
T12411 22635-22640 NNS denotes cells
T12410 22628-22634 NN denotes cancer
T12409 22625-22627 IN denotes in
T12408 22614-22624 NN denotes resistance
T12407 22610-22613 NNP denotes TMZ
T12406 22606-22609 CC denotes and
T12405 22595-22605 NN denotes deficiency
T12404 22590-22594 NNP denotes WWOX
T12403 22587-22589 IN denotes of
T12402 22579-22586 NNS denotes effects
T12401 22575-22578 DT denotes the
T12400 22565-22574 VBD denotes discussed
T12399 22561-22564 CC denotes and
T12398 22559-22560 , denotes ,
T12397 22548-22559 NNS denotes alterations
T12396 22538-22547 JJ denotes metabolic
T12395 22534-22537 CC denotes and
T12394 22524-22533 NN denotes migration
T12393 22519-22523 NN denotes cell
T12392 22507-22518 VBG denotes controlling
T12391 22504-22506 IN denotes in
T12390 22499-22503 NNP denotes WWOX
T12389 22496-22498 IN denotes of
T12388 22491-22495 NN denotes role
T12387 22487-22490 DT denotes the
T12386 22481-22486 VBN denotes shown
T12385 22476-22480 VBP denotes have
T12384 22473-22475 PRP denotes We
T12383 22471-22472 . denotes .
T12382 22466-22471 NNS denotes cells
T12381 22462-22465 NNP denotes GBM
T12380 22459-22461 IN denotes in
T12379 22447-22458 NN denotes sensitivity
T12378 22443-22446 NNP denotes TMZ
T12377 22432-22442 VBG denotes regulating
T12376 22429-22431 IN denotes in
T12375 22424-22428 NNP denotes WWOX
T12374 22420-22423 CC denotes and
T12373 22416-22419 NN denotes p53
T12372 22404-22415 NNS denotes suppressors
T12371 22398-22403 NN denotes tumor
T12370 22395-22397 IN denotes of
T12369 22390-22394 NN denotes role
T12368 22380-22389 JJ denotes potential
T12367 22376-22379 DT denotes the
T12366 22366-22375 VBN denotes discussed
T12365 22361-22365 VBP denotes have
T12364 22358-22360 PRP denotes we
T12363 22350-22357 NN denotes article
T12362 22338-22349 NN denotes perspective
T12361 22333-22337 DT denotes this
T12360 22330-22332 IN denotes in
T12359 22328-22329 , denotes ,
T12358 22321-22328 NN denotes summary
T12357 22318-22320 IN denotes In
T12356 22316-22317 . denotes .
T12355 22308-22316 NN denotes invasion
T12354 22304-22307 CC denotes and
T12353 22297-22303 NN denotes growth
T12352 22292-22296 NN denotes cell
T12351 22285-22291 NN denotes cancer
T12350 22281-22284 DT denotes the
T12349 22276-22280 VB denotes curb
T12348 22273-22275 TO denotes to
T12347 22269-22272 NNP denotes ROS
T12346 22266-22268 IN denotes of
T12345 22255-22265 NN denotes generation
T12344 22248-22254 NNS denotes exerts
T12343 22244-22247 CC denotes and
T12342 22238-22243 NNS denotes cells
T12341 22231-22237 NN denotes cancer
T12340 22228-22230 IN denotes in
T12339 22216-22227 NN denotes consumption
T12338 22208-22215 NN denotes glucose
T12337 22199-22207 VB denotes override
T12336 22196-22198 TO denotes to
T12335 22189-22195 JJ denotes likely
T12334 22186-22188 VBZ denotes is
T12333 22181-22185 NNP denotes WWOX
T12332 22179-22180 , denotes ,
T12331 22168-22179 RB denotes Conceivably
T12330 22166-22167 . denotes .
T12329 22165-22166 -RRB- denotes )
T12328 22161-22165 CD denotes 2012
T12327 22159-22160 , denotes ,
T12326 22156-22159 FW denotes al.
T12325 22153-22155 FW denotes et
T12324 22145-22152 NNP denotes Moncada
T12323 22144-22145 -LRB- denotes (
T12322 22136-22143 NNP denotes Warburg
T12321 22126-22135 JJ denotes so-called
T12320 22122-22125 DT denotes the
T12319 22110-22119 NN denotes advantage
T12318 22103-22109 NN denotes growth
T12317 22099-22102 IN denotes for
T12316 22088-22098 NN denotes glycolysis
T12315 22080-22087 VB denotes utilize
T12314 22073-22079 RB denotes overly
T12313 22070-22072 TO denotes to
T12312 22064-22069 VBN denotes known
T12311 22060-22063 VBP denotes are
T12310 22054-22059 NNS denotes cells
T12309 22047-22053 NNP denotes Cancer
T12308 22045-22046 . denotes .
T12307 22035-22045 NNP denotes Drosophila
T12306 22032-22034 IN denotes in
T12305 22021-22031 NN denotes production
T12304 22017-22020 NNP denotes ROS
T12303 22009-22016 VBZ denotes induces
T12302 21998-22008 NN denotes expression
T12301 21993-21997 NN denotes gene
T12300 21988-21992 NNP denotes Wwox
T12299 21977-21987 JJ denotes functional
T12298 21975-21976 , denotes ,
T12297 21969-21975 NN denotes stress
T12296 21966-21968 NNP denotes UV
T12295 21960-21965 IN denotes Under
T12294 21958-21959 . denotes .
T12293 21957-21958 -RRB- denotes )
T12292 21953-21957 CD denotes 2011
T12291 21951-21952 , denotes ,
T12290 21948-21951 FW denotes al.
T12289 21945-21947 FW denotes et
T12288 21936-21937 -LRB- denotes (
T12287 21932-21935 NNP denotes ROS
T12286 21929-21931 IN denotes of
T12285 21918-21928 NN denotes generation
T12284 21914-21917 IN denotes for
T12283 21907-21913 NN denotes stress
T12282 21897-21906 JJ denotes oxidative
T12281 21893-21896 CC denotes and
T12280 21882-21892 NN denotes metabolism
T12279 21874-21881 JJ denotes aerobic
T12278 21864-21873 VBG denotes involving
T12277 21855-21863 NNS denotes pathways
T12276 21852-21854 IN denotes in
T12275 21840-21851 VB denotes participate
T12274 21837-21839 TO denotes to
T12273 21831-21836 VBN denotes shown
T12272 21828-21830 VBZ denotes is
T12271 21823-21827 NNP denotes Wwox
T12270 21821-21822 , denotes ,
T12269 21816-21821 NN denotes model
T12268 21805-21815 NNP denotes Drosophila
T12267 21803-21804 DT denotes a
T12266 21800-21802 IN denotes In
T12265 21798-21799 . denotes .
T12264 21797-21798 -RRB- denotes )
T12263 21793-21797 CD denotes 2012
T12262 21791-21792 , denotes ,
T12261 21788-21791 FW denotes al.
T12260 21785-21787 FW denotes et
T12259 21779-21784 NNP denotes Salah
T12258 21777-21778 : denotes ;
T12257 21773-21777 CD denotes 2011
T12256 21771-21772 , denotes ,
T12255 21768-21771 FW denotes al.
T12254 21765-21767 FW denotes et
T12253 21760-21764 NNP denotes Mare
T12252 21756-21759 NNP denotes Del
T12251 21755-21756 -LRB- denotes (
T12250 21741-21754 NNS denotes osteosarcomas
T12249 21738-21740 IN denotes of
T12248 21727-21737 NN denotes generation
T12247 21723-21726 CC denotes and
T12246 21721-21722 , denotes ,
T12245 21706-21721 NN denotes steroidogenesis
T12244 21704-21705 , denotes ,
T12243 21698-21704 NN denotes ataxia
T12242 21696-21697 , denotes ,
T12241 21689-21696 NNS denotes defects
T12240 21678-21688 NN denotes metabolism
T12239 21673-21677 NN denotes bone
T12238 21671-21672 , denotes ,
T12237 21662-21671 NN denotes lethality
T12236 21652-21661 JJ denotes postnatal
T12235 21642-21651 VBG denotes including
T12234 21640-21641 , denotes ,
T12233 21636-21640 NNS denotes mice
T12232 21627-21635 NN denotes knockout
T12231 21622-21626 NNP denotes Wwox
T12230 21619-21621 IN denotes in
T12229 21613-21618 VBN denotes shown
T12228 21608-21612 VBN denotes been
T12227 21603-21607 VBP denotes have
T12226 21591-21602 NNS denotes alterations
T12225 21581-21590 JJ denotes Metabolic
T12224 21579-21580 . denotes .
T12223 21578-21579 -RRB- denotes )
T12222 21567-21578 JJ denotes unpublished
T12221 21565-21566 , denotes ,
T12220 21562-21565 FW denotes al.
T12219 21559-21561 FW denotes et
T12218 21554-21558 NNP denotes Chou
T12217 21553-21554 -LRB- denotes (
T12216 21546-21552 NN denotes tissue
T12215 21540-21545 NN denotes brain
T12214 21532-21539 JJ denotes distant
T12213 21527-21531 IN denotes into
T12212 21518-21526 NN denotes invasion
T12211 21510-21517 NN denotes diffuse
T12210 21506-21509 DT denotes the
T12209 21502-21505 IN denotes for
T12208 21494-21501 VB denotes account
T12207 21490-21493 MD denotes may
T12206 21484-21489 NNS denotes cells
T12205 21477-21483 NN denotes glioma
T12204 21463-21476 JJ denotes WWOX-negative
T12196 21418-21423 NNS denotes areas
T12195 21407-21417 NN denotes expression
T12194 21402-21406 NNP denotes WWOX
T12193 21398-21401 JJ denotes low
T12192 21395-21397 TO denotes to
T12191 21389-21394 NNS denotes cells
T12190 21383-21388 NN denotes brain
T12189 21367-21382 JJ denotes WWOX-expressing
T12188 21362-21366 IN denotes from
T12187 21357-21361 RB denotes away
T12186 21352-21356 VB denotes turn
T12185 21348-21351 CC denotes and
T12184 21335-21347 RB denotes individually
T12183 21327-21334 VBP denotes migrate
T12182 21321-21326 NNS denotes cells
T12181 21314-21320 NN denotes glioma
T12180 21300-21313 JJ denotes WWOX-negative
T12179 21298-21299 , denotes ,
T12178 21287-21298 RB denotes Conceivably
T12177 21285-21286 . denotes .
T12176 21280-21285 NNS denotes cells
T12175 21266-21279 JJ denotes WWOX-positive
T12174 21262-21265 DT denotes the
T12173 21257-21261 IN denotes from
T12172 21252-21256 RB denotes away
T12171 21247-21251 VB denotes move
T12170 21244-21246 TO denotes to
T12169 21238-21243 NNS denotes cells
T12168 21224-21237 JJ denotes WWOX-negative
T12167 21221-21223 IN denotes of
T12166 21212-21220 NN denotes mobility
T12165 21208-21211 DT denotes the
T12164 21198-21207 VBZ denotes increases
T12163 21193-21197 DT denotes this
T12162 21189-21192 CC denotes and
T12161 21187-21188 , denotes ,
T12160 21182-21187 NNS denotes cells
T12159 21168-21181 JJ denotes WWOX-positive
T12158 21159-21167 JJ denotes parental
T12157 21156-21158 IN denotes by
T12156 21144-21155 NN denotes recognition
T12155 21139-21143 VBP denotes lose
T12154 21133-21138 NNS denotes cells
T12153 21119-21132 JJ denotes WWOX-negative
T12152 21117-21118 , denotes ,
T12151 21096-21117 NN denotes membrane/cytoskeleton
T12150 21091-21095 NN denotes cell
T12149 21087-21090 DT denotes the
T12148 21084-21086 IN denotes on
T12147 21075-21083 VBN denotes anchored
T12146 21072-21074 VBZ denotes is
T12145 21067-21071 NNP denotes WWOX
T12144 21064-21066 IN denotes of
T12143 21056-21063 NN denotes portion
T12142 21054-21055 DT denotes a
T12141 21048-21053 IN denotes While
T12140 21046-21047 . denotes .
T12139 21045-21046 -RRB- denotes )
T12138 21034-21045 JJ denotes unpublished
T12137 21032-21033 , denotes ,
T12136 21029-21032 FW denotes al.
T12135 21026-21028 FW denotes et
T12134 21021-21025 NNP denotes Chou
T12133 21020-21021 -LRB- denotes (
T12132 21007-21019 RB denotes collectively
T12131 20999-21006 VBP denotes migrate
T12130 20993-20998 NNS denotes cells
T12129 20988-20992 NN denotes type
T12128 20983-20987 JJ denotes wild
T12127 20981-20982 , denotes ,
T12126 20973-20981 NN denotes contrast
T12124 20968-20969 . denotes .
T12123 20956-20968 RB denotes aggressively
T12122 20952-20955 CC denotes and
T12121 20939-20951 RB denotes individually
T12120 20931-20938 VBP denotes migrate
T12119 20929-20930 -RRB- denotes )
T12118 20918-20929 NNS denotes fibroblasts
T12117 20908-20917 JJ denotes embryonic
T12116 20906-20907 , denotes ,
T12115 20902-20906 FW denotes e.g.
T12114 20901-20902 -LRB- denotes (
T12113 20895-20900 NNS denotes cells
T12112 20886-20894 NN denotes knockout
T12111 20881-20885 NN denotes gene
T12110 20876-20880 NNP denotes Wwox
T12109 20870-20875 NN denotes mouse
T12108 20865-20869 IN denotes that
T12107 20852-20864 NNS denotes observations
T12106 20848-20851 PRP$ denotes our
T12105 20843-20847 IN denotes upon
T12104 20837-20842 VBN denotes based
T12103 20834-20836 VBZ denotes is
T12102 20823-20833 NN denotes assumption
T12101 20818-20822 DT denotes This
T12100 20816-20817 . denotes .
T12099 20804-20816 RB denotes collectively
T12098 20799-20803 IN denotes than
T12097 20792-20798 RB denotes rather
T12096 20779-20791 RB denotes individually
T12095 20771-20778 VB denotes migrate
T12094 20769-20770 , denotes ,
T12093 20759-20769 NNS denotes properties
T12092 20749-20758 JJ denotes cell-like
T12091 20744-20748 NN denotes stem
T12090 20739-20743 IN denotes with
T12089 20737-20738 , denotes ,
T12088 20732-20737 NNS denotes cells
T12087 20725-20731 NN denotes glioma
T12086 20720-20724 IN denotes that
T12085 20712-20719 VBP denotes believe
T12084 20709-20711 PRP denotes We
T12083 20707-20708 . denotes .
T12082 20706-20707 -RRB- denotes )
T12081 20702-20706 CD denotes 2012
T12080 20700-20701 , denotes ,
T12079 20697-20700 FW denotes al.
T12078 20694-20696 FW denotes et
T12077 20688-20693 NNP denotes Chang
T12076 20687-20688 -LRB- denotes (
T12075 20681-20686 NNS denotes cells
T12074 20674-20680 NN denotes cancer
T12073 20671-20673 IN denotes in
T12072 20661-20670 NN denotes apoptosis
T12071 20654-20660 VBZ denotes causes
T12070 20650-20653 CC denotes and
T12069 20640-20649 NN denotes migration
T12068 20635-20639 NN denotes cell
T12067 20631-20634 CC denotes and
T12066 20624-20630 NN denotes growth
T12065 20602-20623 JJ denotes anchorage-independent
T12064 20591-20601 VBZ denotes suppresses
T12063 20586-20590 NNP denotes WWOX
T12062 20582-20585 CC denotes and
T12061 20580-20581 , denotes ,
T12060 20577-20580 NN denotes p53
T12059 20575-20576 , denotes ,
T12058 20574-20575 -RRB- denotes )
T12057 20568-20574 NN denotes factor
T12056 20554-20567 JJ denotes antiapoptotic
T12055 20540-20553 JJ denotes TGF-β-induced
T12054 20539-20540 -LRB- denotes (
T12053 20533-20538 CD denotes TIAF1
T12052 20530-20532 IN denotes of
T12051 20519-20529 NN denotes expression
T12050 20511-20518 JJ denotes Ectopic
T12049 20509-20510 . denotes .
T12048 20508-20509 -RRB- denotes )
T12047 20504-20508 CD denotes 2011
T12046 20502-20503 , denotes ,
T12045 20499-20502 FW denotes al.
T12044 20496-20498 FW denotes et
T12043 20491-20495 NNP denotes Mare
T12042 20487-20490 NNP denotes Del
T12041 20485-20486 : denotes ;
T12040 20481-20485 CD denotes 2009
T12039 20479-20480 , denotes ,
T12038 20476-20479 FW denotes al.
T12037 20473-20475 FW denotes et
T12036 20465-20472 NNP denotes Gourley
T12035 20464-20465 -LRB- denotes (
T12034 20458-20463 NNS denotes cells
T12033 20445-20457 NN denotes osteosarcoma
T12032 20441-20444 CC denotes and
T12031 20434-20440 NN denotes cancer
T12030 20426-20433 JJ denotes ovarian
T12029 20423-20425 IN denotes of
T12028 20413-20422 NN denotes migration
T12027 20401-20412 VBZ denotes facilitates
T12026 20396-20400 NNP denotes WWOX
T12025 20393-20395 IN denotes of
T12024 20388-20392 NN denotes loss
T12023 20386-20387 , denotes ,
T12022 20379-20386 NN denotes example
T12021 20375-20378 IN denotes For
T12020 20373-20374 . denotes .
T12019 20364-20373 NN denotes migration
T12018 20359-20363 NN denotes cell
T12017 20351-20358 VB denotes enhance
T12016 20348-20350 TO denotes to
T12015 20339-20347 VBN denotes expected
T12014 20336-20338 VBZ denotes is
T12013 20325-20335 NN denotes expression
T12012 20320-20324 NNP denotes WWOX
T12011 20317-20319 IN denotes of
T12010 20312-20316 NN denotes lack
T12009 20310-20311 , denotes ,
T12008 20306-20310 RB denotes Also
T12007 20304-20305 . denotes .
T12006 20303-20304 -RRB- denotes )
T12005 20299-20303 CD denotes 2012
T12004 20297-20298 , denotes ,
T12003 20294-20297 FW denotes al.
T12002 20291-20293 FW denotes et
T12001 20282-20290 NNP denotes Hagemann
T12000 20280-20281 : denotes ;
T11999 20276-20280 CD denotes 2003
T11998 20274-20275 , denotes ,
T11997 20271-20274 FW denotes al.
T11996 20268-20270 FW denotes et
T11995 20261-20267 NNP denotes Junker
T11994 20259-20260 : denotes ;
T11993 20255-20259 CD denotes 2002
T11992 20253-20254 , denotes ,
T11991 20250-20253 FW denotes al.
T11990 20247-20249 FW denotes et
T11989 20239-20246 NNP denotes Delpech
T11988 20238-20239 -LRB- denotes (
T11987 20228-20237 NN denotes migration
T11986 20222-20227 PRP$ denotes their
T11985 20211-20221 VB denotes facilitate
T11984 20208-20210 TO denotes to
T11983 20189-20207 NNS denotes metalloproteinases
T11982 20185-20188 CC denotes and
T11981 20170-20184 NNS denotes hyaluronidases
T11977 20155-20156 -RRB- denotes )
T11976 20151-20155 CD denotes 2012
T11975 20149-20150 , denotes ,
T11974 20146-20149 FW denotes al.
T11973 20143-20145 FW denotes et
T11972 20135-20142 NNP denotes Yoshida
T11971 20133-20134 : denotes ;
T11970 20129-20133 CD denotes 2004
T11969 20127-20128 , denotes ,
T11968 20124-20127 FW denotes al.
T11967 20121-20123 FW denotes et
T11966 20115-20120 NNP denotes Murai
T11965 20114-20115 -LRB- denotes (
T11964 20103-20113 NN denotes hyaluronan
T11963 20096-20102 NN denotes matrix
T11962 20090-20095 NN denotes brain
T11961 20085-20089 IN denotes with
T11960 20073-20084 VBG denotes interacting
T11959 20069-20072 IN denotes for
T11958 20060-20068 NN denotes receptor
T11957 20058-20059 DT denotes a
T11956 20055-20057 IN denotes as
T11955 20050-20054 NNP denotes CD44
T11954 20042-20049 VBP denotes possess
T11953 20036-20041 NNS denotes cells
T11952 20029-20035 NNP denotes Glioma
T11951 20027-20028 . denotes .
T11950 20026-20027 -RRB- denotes )
T11949 20022-20026 CD denotes 2005
T11948 20020-20021 , denotes ,
T11947 20017-20020 FW denotes al.
T11946 20014-20016 FW denotes et
T11945 20006-20013 NNP denotes Lefranc
T11944 20005-20006 -LRB- denotes (
T11943 19999-20004 NN denotes death
T11942 19989-19998 JJ denotes apoptotic
T11941 19986-19988 TO denotes to
T11940 19976-19985 JJ denotes resistant
T11939 19970-19975 NNS denotes cells
T11938 19960-19969 VBG denotes migrating
T11937 19954-19959 DT denotes these
T11936 19947-19953 VB denotes confer
T11935 19944-19946 TO denotes to
T11934 19935-19943 VBN denotes believed
T11933 19931-19934 VBP denotes are
T11932 19929-19930 , denotes ,
T11931 19920-19929 NN denotes autophagy
T11930 19916-19919 CC denotes and
T11929 19914-19915 , denotes ,
T11928 19909-19914 NNP denotes NF-κB
T11927 19907-19908 , denotes ,
T11926 19903-19907 NNP denotes mTOR
T11925 19901-19902 , denotes ,
T11924 19898-19901 NNP denotes Akt
T12203 21460-21462 IN denotes of
T12202 21451-21459 NN denotes behavior
T12201 21441-21450 JJ denotes migratory
T12200 21437-21440 DT denotes the
T12199 21435-21436 , denotes ,
T12198 21425-21435 RB denotes Apparently
T12197 21423-21424 . denotes .
T11923 19896-19897 , denotes ,
T11922 19892-19896 NNP denotes PI3K
T11921 19882-19891 VBG denotes involving
T11920 19880-19881 , denotes ,
T11919 19872-19880 NNS denotes pathways
T11918 19865-19871 NNP denotes Signal
T11917 19863-19864 . denotes .
T11916 19857-19863 NN denotes tissue
T11915 19851-19856 NN denotes brain
T11914 19843-19850 JJ denotes distant
T11913 19838-19842 IN denotes into
T11912 19825-19837 NN denotes infiltration
T11911 19817-19824 NN denotes diffuse
T11910 19811-19816 PRP$ denotes their
T11909 19808-19810 VBZ denotes is
T11908 19800-19807 NNS denotes gliomas
T11907 19790-19799 JJ denotes malignant
T11906 19786-19789 IN denotes for
T11905 19770-19785 NNS denotes characteristics
T11904 19763-19769 JJ denotes unique
T11903 19759-19762 DT denotes the
T11902 19756-19758 IN denotes of
T11901 19752-19755 CD denotes One
T11900 19750-19751 . denotes .
T11899 19739-19750 VBN denotes established
T11898 19736-19738 VB denotes be
T11897 19733-19735 TO denotes to
T11896 19725-19732 VBZ denotes remains
T11895 19721-19724 CC denotes and
T11894 19713-19720 JJ denotes unknown
T11893 19710-19712 VBZ denotes is
T11892 19706-19709 NN denotes p53
T11891 19695-19705 JJ denotes endogenous
T11890 19692-19694 IN denotes of
T11889 19683-19691 NN denotes function
T11888 19679-19682 DT denotes the
T11887 19674-19678 IN denotes with
T11886 19662-19673 NNS denotes counteracts
T11885 19657-19661 NNP denotes WWOX
T11884 19646-19656 JJ denotes endogenous
T11883 19638-19645 IN denotes Whether
T11882 19636-19637 . denotes ?
T11881 19630-19636 NN denotes growth
T11880 19623-19629 NN denotes cancer
T11879 19614-19622 VBG denotes allowing
T11878 19609-19613 RB denotes thus
T11877 19607-19608 , denotes ,
T11876 19599-19607 NN denotes function
T11875 19591-19596 JJ denotes other
T11874 19586-19590 DT denotes each
T11873 19575-19585 VBP denotes counteract
T11872 19570-19574 PRP denotes they
T11871 19567-19569 VBP denotes do
T11870 19565-19566 , denotes ,
T11869 19563-19565 CC denotes Or
T11868 19561-19562 . denotes ?
T11867 19551-19561 RB denotes eventually
T11866 19543-19550 NN denotes control
T11865 19538-19542 VBP denotes lose
T11864 19534-19537 CC denotes but
T11863 19522-19533 NN denotes progression
T11862 19515-19521 NN denotes cancer
T11861 19506-19514 VBG denotes blocking
T11860 19503-19505 IN denotes in
T11859 19487-19502 RB denotes synergistically
T11858 19483-19486 VBP denotes act
T11857 19474-19482 NNS denotes proteins
T11856 19468-19473 DT denotes these
T11855 19465-19467 VB denotes Do
T11854 19463-19464 . denotes .
T11853 19462-19463 -RRB- denotes )
T11852 19451-19462 JJ denotes unpublished
T11851 19449-19450 , denotes ,
T11850 19446-19449 FW denotes al.
T11849 19443-19445 FW denotes et
T11848 19437-19442 NNP denotes Chang
T11847 19435-19436 : denotes ;
T11846 19431-19435 CD denotes 2005
T11845 19429-19430 , denotes ,
T11844 19426-19429 FW denotes al.
T11843 19423-19425 FW denotes et
T11842 19419-19422 NNP denotes Lai
T11841 19418-19419 -LRB- denotes (
T11840 19406-19417 NN denotes progression
T11839 19399-19405 NN denotes cancer
T11838 19396-19398 IN denotes of
T11837 19390-19395 NN denotes stage
T11836 19384-19389 JJ denotes early
T11835 19380-19383 DT denotes the
T11834 19373-19379 IN denotes during
T11833 19361-19372 VBN denotes upregulated
T11832 19347-19360 RB denotes significantly
T11831 19343-19346 VBP denotes are
T11830 19341-19342 , denotes ,
T11829 19337-19341 FW denotes etc.
T11828 19333-19336 CC denotes and
T11827 19331-19332 , denotes ,
T11826 19327-19331 NNP denotes PP2A
T11825 19325-19326 , denotes ,
T11824 19321-19325 NNP denotes PTEN
T11823 19319-19320 , denotes ,
T11822 19314-19319 NNP denotes Smad4
T11821 19312-19313 , denotes ,
T11820 19308-19312 NNP denotes WWOX
T11819 19306-19307 , denotes ,
T11818 19303-19306 NN denotes p53
T11817 19301-19302 , denotes ,
T11816 19297-19301 FW denotes e.g.
T11815 19295-19296 , denotes ,
T11814 19287-19295 NNS denotes proteins
T11813 19276-19286 NN denotes suppressor
T11812 19270-19275 NN denotes tumor
T11811 19265-19269 JJ denotes many
T11810 19260-19264 DT denotes that
T11809 19255-19259 VB denotes find
T11808 19252-19254 TO denotes to
T11807 19241-19251 JJ denotes surprising
T11806 19237-19240 RB denotes not
T11805 19234-19236 VBZ denotes is
T11804 19231-19233 PRP denotes it
T11803 19229-19230 , denotes ,
T11802 19222-19229 RB denotes However
T11801 19220-19221 . denotes .
T11800 19210-19220 NN denotes literature
T11799 19206-19209 DT denotes the
T11798 19203-19205 IN denotes in
T11797 19192-19202 VBN denotes documented
T11796 19187-19191 VBN denotes been
T11795 19181-19186 RB denotes never
T11794 19177-19180 VBZ denotes has
T11793 19165-19176 NNS denotes suppressors
T11792 19159-19164 NN denotes tumor
T11791 19153-19158 IN denotes among
T11790 19142-19152 NN denotes antagonism
T11789 19131-19141 JJ denotes Functional
T11788 19129-19130 . denotes .
T11787 19126-19129 NN denotes p53
T11786 19122-19125 CC denotes and
T11785 19117-19121 NNP denotes WWOX
T11784 19114-19116 IN denotes of
T11783 19105-19113 NN denotes function
T11782 19095-19104 JJ denotes apoptotic
T11781 19091-19094 DT denotes the
T11780 19086-19090 IN denotes with
T11779 19076-19085 VB denotes interfere
T11778 19072-19075 MD denotes may
T11777 19070-19071 , denotes ,
T11776 19066-19070 NNS denotes GBMs
T11775 19063-19065 IN denotes in
T11774 19055-19062 JJ denotes present
T11773 19051-19054 VBP denotes are
T11772 19045-19050 WDT denotes which
T11771 19043-19044 , denotes ,
T11770 19035-19043 NNS denotes proteins
T11769 19023-19034 JJ denotes p53-binding
T11768 19018-19022 IN denotes that
T11767 19015-19017 VBZ denotes is
T11766 19006-19014 NN denotes scenario
T11765 18999-19005 JJ denotes likely
T11764 18997-18998 DT denotes A
T11763 18995-18996 . denotes .
T11762 18994-18995 -RRB- denotes )
T11732 18884-18890 VBP denotes induce
T11731 18875-18883 NNS denotes proteins
T11730 18870-18874 DT denotes both
T11729 18866-18869 CC denotes and
T11728 18864-18865 , denotes ,
T11727 18860-18864 NNP denotes WWOX
T11726 18855-18859 IN denotes with
T11725 18845-18854 VBZ denotes interacts
T11724 18832-18844 RB denotes functionally
T11723 18828-18831 NN denotes p53
T11722 18823-18827 IN denotes that
T11721 18817-18822 VBN denotes shown
T11720 18812-18816 VBP denotes have
T11719 18809-18811 PRP denotes we
T11718 18807-18808 , denotes ,
T11717 18802-18807 NNS denotes cases
T11716 18797-18801 JJS denotes most
T11715 18794-18796 IN denotes In
T11714 18792-18793 . denotes .
T11713 18791-18792 -RRB- denotes )
T11712 18787-18791 CD denotes 2012
T11711 18785-18786 , denotes ,
T11710 18782-18785 FW denotes al.
T11709 18779-18781 FW denotes et
T11708 18772-18778 NNP denotes Chiang
T11707 18771-18772 -LRB- denotes (
T11706 18763-18770 JJ denotes unusual
T11705 18760-18762 VBZ denotes is
T11704 18756-18759 NN denotes p53
T11703 18751-18755 NN denotes type
T11702 18746-18750 JJ denotes wild
T11701 18735-18745 VBG denotes possessing
T11700 18729-18734 NNS denotes cells
T11699 18722-18728 NN denotes glioma
T11698 18719-18721 IN denotes of
T11697 18709-18718 NN denotes apoptosis
T11696 18700-18708 VBG denotes inducing
T11695 18697-18699 IN denotes in
T11694 18692-18696 NNP denotes WWOX
T11693 18684-18691 JJ denotes ectopic
T11692 18681-18683 IN denotes of
T11691 18673-18680 NN denotes Failure
T11690 18671-18672 . denotes .
T11689 18662-18671 NN denotes apoptosis
T11688 18653-18661 VBG denotes inducing
T11687 18649-18652 IN denotes for
T11686 18639-18648 VBN denotes activated
T11685 18636-18638 VBZ denotes is
T11684 18631-18635 NNP denotes WWOX
T11683 18623-18630 JJ denotes ectopic
T11682 18621-18622 , denotes ,
T11681 18616-18621 NN denotes event
T11680 18611-18615 DT denotes this
T11679 18608-18610 IN denotes In
T11980 20162-20169 NN denotes secrete
T11979 20158-20161 CC denotes and
T11978 20156-20157 , denotes ,
T11678 18606-18607 . denotes .
T11677 18605-18606 -RRB- denotes )
T11676 18601-18605 CD denotes 2009
T11675 18599-18600 , denotes ,
T11674 18596-18599 FW denotes al.
T11673 18593-18595 FW denotes et
T11672 18588-18592 NNP denotes Hong
T11671 18587-18588 -LRB- denotes (
T11670 18579-18586 NN denotes pathway
T11669 18568-18578 NN denotes activation
T11668 18558-18567 JJ denotes classical
T11667 18554-18557 DT denotes the
T11666 18551-18553 IN denotes in
T11665 18542-18550 NNS denotes proteins
T11664 18531-18541 JJ denotes downstream
T11663 18528-18530 IN denotes of
T11662 18514-18527 NN denotes participation
T11661 18506-18513 IN denotes without
T11660 18500-18505 NNS denotes cells
T11659 18485-18499 NNS denotes neuroblastomas
T11658 18481-18484 CC denotes and
T11657 18474-18480 NN denotes cancer
T11656 18465-18473 NN denotes prostate
T11655 18462-18464 IN denotes of
T11654 18452-18461 NN denotes apoptosis
T11653 18444-18451 VBZ denotes induces
T11652 18440-18443 JJ denotes C1q
T11651 18429-18439 VBP denotes complement
T11650 18423-18428 NN denotes serum
T11649 18421-18422 , denotes ,
T11648 18414-18421 NN denotes example
T11647 18410-18413 IN denotes For
T11646 18408-18409 . denotes .
T11645 18402-18408 NN denotes growth
T11644 18395-18401 NN denotes cancer
T11643 18386-18394 VBG denotes blocking
T11642 18382-18385 IN denotes for
T11641 18373-18381 VBN denotes utilized
T11640 18370-18372 VB denotes be
T11639 18366-18369 MD denotes can
T11638 18358-18365 NNS denotes factors
T11637 18352-18357 NNP denotes Serum
T11636 18350-18351 . denotes .
T11635 18349-18350 -RRB- denotes )
T11634 18345-18349 CD denotes 2012
T11633 18343-18344 , denotes ,
T11632 18340-18343 FW denotes al.
T11631 18337-18339 FW denotes et
T11630 18332-18336 NNP denotes Holt
T11629 18331-18332 -LRB- denotes (
T11628 18326-18330 NN denotes vivo
T11627 18323-18325 IN denotes in
T11626 18317-18322 NN denotes death
T11625 18312-18316 NN denotes cell
T11624 18305-18311 NN denotes cancer
T11623 18293-18304 JJ denotes TMZ-induced
T11622 18284-18292 VBZ denotes enhances
T11621 18272-18283 NN denotes selumetinib
T11620 18269-18271 IN denotes by
T11619 18265-18268 NNP denotes MEK
T11618 18262-18264 IN denotes of
T11617 18251-18261 NN denotes inhibition
T11616 18242-18250 JJ denotes specific
T11615 18240-18241 , denotes ,
T11614 18234-18240 RB denotes Indeed
T11613 18232-18233 . denotes .
T11612 18231-18232 -RRB- denotes )
T11611 18220-18231 JJ denotes unpublished
T11610 18218-18219 , denotes ,
T11609 18215-18218 FW denotes al.
T11608 18212-18214 FW denotes et
T11607 18209-18211 NNP denotes Lu
T11606 18208-18209 -LRB- denotes (
T11605 18202-18207 NNS denotes cells
T11604 18195-18201 NN denotes cancer
T11603 18192-18194 IN denotes of
T11602 18186-18191 NNS denotes types
T11601 18181-18185 JJ denotes many
T11600 18178-18180 IN denotes of
T11599 18168-18177 NN denotes apoptosis
T11761 18990-18994 CD denotes 2012
T11760 18988-18989 , denotes ,
T11759 18985-18988 FW denotes al.
T11758 18982-18984 FW denotes et
T11757 18979-18981 NNP denotes Su
T11756 18977-18978 : denotes ;
T11755 18973-18977 CD denotes 2012
T11754 18971-18972 , denotes ,
T11753 18967-18971 CD denotes 2010
T11752 18965-18966 , denotes ,
T11751 18961-18965 CD denotes 2007
T11750 18959-18960 , denotes ,
T11749 18958-18959 NN denotes b
T11748 18957-18958 , denotes ,
T11747 18952-18957 CD denotes 2005a
T11746 18950-18951 , denotes ,
T11745 18946-18950 CD denotes 2003
T11744 18944-18945 , denotes ,
T11743 18940-18944 CD denotes 2001
T11742 18938-18939 , denotes ,
T11741 18935-18938 FW denotes al.
T11740 18932-18934 FW denotes et
T11739 18926-18931 NNP denotes Chang
T11738 18925-18926 -LRB- denotes (
T11737 18918-18924 NN denotes manner
T11736 18906-18917 JJ denotes synergistic
T11735 18904-18905 DT denotes a
T11734 18901-18903 IN denotes in
T11733 18891-18900 NN denotes apoptosis
T9509 17661-17662 . denotes .
T9508 17650-17661 VBN denotes established
T9507 17647-17649 VB denotes be
T9506 17644-17646 TO denotes to
T9505 17636-17643 VBZ denotes remains
T9504 17632-17635 CC denotes and
T9503 17624-17631 JJ denotes unknown
T9502 17621-17623 VBZ denotes is
T9501 17612-17620 NNS denotes isoforms
T9500 17608-17611 NN denotes p53
T9499 17597-17607 VBG denotes expressing
T9498 17593-17596 NNP denotes GBM
T9497 17590-17592 IN denotes in
T9496 17580-17589 NN denotes apoptosis
T9495 17573-17579 VBZ denotes causes
T9494 17568-17572 NNP denotes WWOX
T10024 17901-17908 VBG denotes causing
T10023 17897-17900 IN denotes for
T10022 17889-17896 NN denotes complex
T10021 17884-17888 DT denotes this
T10020 17872-17883 VBZ denotes dissociates
T10019 17868-17871 NNP denotes PMA
T10018 17863-17867 IN denotes that
T10017 17859-17862 CC denotes and
T10016 17857-17858 , denotes ,
T10015 17854-17857 NNP denotes MEK
T10014 17848-17853 VBZ denotes binds
T10013 17843-17847 NNP denotes WWOX
T10012 17841-17842 . denotes .
T10011 17836-17841 NNS denotes cells
T10010 17832-17835 NNP denotes GBM
T10009 17829-17831 IN denotes in
T10008 17817-17828 NN denotes sensitivity
T10007 17813-17816 NNP denotes TMZ
T10006 17809-17812 CC denotes and
T10005 17799-17808 NN denotes apoptosis
T10004 17792-17798 VB denotes affect
T10003 17789-17791 TO denotes to
T10002 17782-17788 JJ denotes likely
T10001 17778-17781 VBP denotes are
T10000 17774-17777 NN denotes p53
T9999 17767-17773 CC denotes and/or
T9998 17762-17766 NNP denotes WWOX
T9997 17758-17761 IN denotes for
T9996 17749-17757 NNS denotes proteins
T9995 17741-17748 VBG denotes Binding
T9994 17739-17740 . denotes .
T9993 17729-17739 VBN denotes determined
T9992 17724-17728 VBN denotes been
T9991 17718-17723 RB denotes never
T9990 17714-17717 VBZ denotes has
T9989 17702-17713 NN denotes sensitivity
T9988 17698-17701 NNP denotes TMZ
T9987 17690-17697 VBZ denotes affects
T9986 17685-17689 NNP denotes WWOX
T9985 17677-17684 IN denotes Whether
T9451 17334-17338 NNP denotes WWOX
T9493 17560-17567 IN denotes Whether
T9492 17558-17559 . denotes .
T9491 17549-17558 NN denotes apoptosis
T9490 17542-17548 VB denotes induce
T9489 17539-17541 TO denotes to
T9488 17534-17538 JJ denotes able
T9487 17531-17533 VBZ denotes is
T9486 17526-17530 NNP denotes WWOX
T9485 17522-17525 CC denotes and
T9484 17520-17521 , denotes ,
T9483 17515-17520 NNS denotes cells
T9482 17511-17514 NNP denotes GBM
T9481 17508-17510 IN denotes in
T9480 17503-17507 NNP denotes WWOX
T9479 17495-17502 JJ denotes ectopic
T9478 17490-17494 NN denotes bind
T9477 17486-17489 RB denotes not
T9476 17483-17486 MD denotes can
T9475 17474-17482 NNS denotes proteins
T9474 17470-17473 NN denotes p53
T9473 17463-17469 JJ denotes Mutant
T9472 17461-17462 . denotes .
T9471 17460-17461 -RRB- denotes )
T9470 17459-17460 CD denotes 2
T9469 17452-17458 NN denotes Figure
T9468 17451-17452 -LRB- denotes (
T9467 17441-17450 NN denotes apoptosis
T9466 17432-17440 VBG denotes inducing
T9465 17429-17431 IN denotes in
T9464 17420-17428 NN denotes function
T9463 17412-17417 JJ denotes other
T9462 17407-17411 DT denotes each
T9461 17396-17406 VBG denotes nullifying
T9460 17388-17395 RB denotes thereby
T9459 17386-17387 , denotes ,
T9458 17376-17386 NN denotes antagonism
T9457 17365-17375 JJ denotes functional
T9456 17363-17364 DT denotes a
T9455 17358-17362 VB denotes have
T9454 17355-17357 TO denotes to
T9453 17348-17354 VBP denotes appear
T9452 17339-17347 NNS denotes proteins
T9450 17326-17333 JJ denotes ectopic
T9449 17322-17325 CC denotes and
T9448 17318-17321 NN denotes p53
T9447 17313-17317 NN denotes type
T9446 17308-17312 JJ denotes wild
T9445 17303-17307 DT denotes both
T9444 17301-17302 , denotes ,
T9443 17296-17301 NNS denotes cells
T9442 17292-17295 NNP denotes GBM
T9441 17289-17291 IN denotes in
T9440 17284-17288 IN denotes that
T9439 17274-17283 VBP denotes postulate
T9438 17271-17273 PRP denotes We
T9437 17269-17270 . denotes .
T9436 17259-17269 VBN denotes determined
T9435 17256-17258 VB denotes be
T9434 17253-17255 TO denotes to
T9433 17245-17252 VBZ denotes remains
T9432 17240-17244 NNP denotes WWOX
T9431 17235-17239 IN denotes with
T9430 17227-17234 NN denotes protein
T9429 17222-17226 DT denotes this
T9428 17219-17221 IN denotes of
T9427 17211-17218 JJ denotes binding
T9426 17209-17210 , denotes ,
T9425 17203-17209 NNP denotes Δ40p53
T9424 17200-17202 IN denotes in
T9423 17194-17199 NNP denotes Ser46
T9422 17191-17193 IN denotes of
T9421 17182-17190 NN denotes presence
T9420 17178-17181 DT denotes the
T9419 17170-17177 IN denotes Despite
T9418 17168-17169 . denotes .
T9417 17156-17168 NNS denotes interactions
T9416 17148-17155 JJ denotes binding
T9415 17144-17147 DT denotes the
T9414 17135-17143 VBZ denotes enhances
T9413 17123-17134 NN denotes irradiation
T9412 17120-17122 NNP denotes UV
T9411 17118-17119 . denotes .
T9410 17117-17118 -RRB- denotes )
T9409 17112-17117 JJ denotes 2005b
T9408 17110-17111 , denotes ,
T9407 17107-17110 FW denotes al.
T9406 17104-17106 FW denotes et
T9405 17098-17103 NNP denotes Chang
T9404 17097-17098 -LRB- denotes (
T9403 17081-17096 NN denotes phosphorylation
T9402 17075-17080 NNP denotes Ser46
T9401 17070-17074 IN denotes with
T9400 17066-17069 NN denotes p53
T9399 17061-17065 NN denotes type
T9398 17056-17060 JJ denotes wild
T9397 17050-17055 VBZ denotes binds
T9396 17045-17049 NNP denotes WWOX
T9395 17035-17044 VBN denotes Activated
T9394 17033-17034 . denotes .
T9393 17029-17033 NNP denotes WWOX
T9392 17025-17028 CC denotes and
T9391 17017-17024 NNS denotes mutants
T9390 17013-17016 NN denotes p53
T9389 17010-17012 IN denotes of
T9388 16993-17009 NN denotes gain-of-function
T9387 16989-16992 DT denotes the
T9386 16981-16988 IN denotes between
T9385 16968-16980 NNS denotes interactions
T9384 16963-16967 IN denotes upon
T9383 16955-16962 VBZ denotes depends
T9382 16949-16954 NNS denotes cells
T9381 16936-16948 NN denotes glioblastoma
T9380 16930-16935 JJ denotes human
T9379 16927-16929 IN denotes of
T9378 16918-16926 NN denotes survival
T9377 16914-16917 DT denotes the
T9376 16909-16913 IN denotes that
T9375 16902-16908 VB denotes assume
T9374 16899-16901 TO denotes to
T9373 16888-16898 JJ denotes reasonable
T9372 16885-16887 VBZ denotes is
T9371 16882-16884 PRP denotes it
T9370 16880-16881 , denotes ,
T9369 16873-16880 JJ denotes unknown
T9368 16869-16872 VBP denotes are
T9367 16858-16868 NNS denotes mechanisms
T9366 16847-16857 VBG denotes underlying
T9365 16843-16846 DT denotes the
T9364 16837-16842 IN denotes While
T9363 16835-16836 . denotes .
T9362 16834-16835 -RRB- denotes )
T9361 16830-16834 CD denotes 2012
T9360 16828-16829 , denotes ,
T9359 16825-16828 FW denotes al.
T9358 16822-16824 FW denotes et
T9357 16815-16821 NNP denotes Chiang
T9356 16814-16815 -LRB- denotes (
T9355 16806-16813 NN denotes pathway
T9354 16784-16805 JJ denotes caspase-3-independent
T9353 16780-16783 CC denotes and
T9352 16755-16779 JJ denotes mitochondria-independent
T9351 16753-16754 DT denotes a
T9350 16749-16752 IN denotes via
T9349 16743-16748 NNS denotes cells
T9348 16735-16742 NN denotes U373-MG
T9347 16732-16734 IN denotes of
T9346 16722-16731 NN denotes apoptosis
T9345 16714-16721 VBZ denotes induces
T9344 16709-16713 NNP denotes WWOX
T9343 16707-16708 , denotes ,
T9342 16704-16707 NNP denotes TMZ
T9341 16697-16703 IN denotes Unlike
T9340 16695-16696 . denotes .
T9339 16692-16695 NN denotes p53
T9338 16687-16691 NN denotes type
T9337 16682-16686 JJ denotes wild
T9336 16671-16681 VBG denotes expressing
T9335 16664-16670 JJ denotes U87-MG
T9334 16659-16663 IN denotes with
T9333 16652-16658 NN denotes effect
T9332 16649-16651 DT denotes no
T9270 16298-16300 VBZ denotes is
T9269 16287-16297 NN denotes expression
T9268 16282-16286 NNP denotes WWOX
T9267 16274-16281 VBN denotes Altered
T9266 16272-16273 . denotes .
T9265 16271-16272 -RRB- denotes )
T9264 16267-16271 CD denotes 2011
T9263 16265-16266 , denotes ,
T9262 16262-16265 FW denotes al.
T9261 16259-16261 FW denotes et
T9260 16252-16258 JJ denotes Blough
T9259 16251-16252 -LRB- denotes (
T9258 16243-16250 NNS denotes gliomas
T9257 16240-16242 IN denotes in
T9256 16228-16239 NN denotes sensitivity
T9255 16224-16227 NNP denotes TMZ
T9254 16217-16223 VB denotes reduce
T9253 16209-16216 NNS denotes mutants
T9252 16205-16208 NN denotes p53
T9251 16203-16204 . denotes .
T9250 16202-16203 -RRB- denotes )
T9249 16198-16202 CD denotes 2011
T9248 16196-16197 , denotes ,
T9247 16193-16196 FW denotes al.
T9246 16190-16192 FW denotes et
T9245 16183-16189 JJ denotes Blough
T9244 16182-16183 -LRB- denotes (
T9243 16171-16181 NN denotes resistance
T9242 16167-16170 NNP denotes TMZ
T9241 16163-16166 DT denotes the
T9240 16153-16162 VBZ denotes increases
T9239 16149-16152 NN denotes p53
T9238 16144-16148 NN denotes type
T9237 16139-16143 JJ denotes wild
T9236 16131-16138 IN denotes whereas
T9235 16129-16130 , denotes ,
T9234 16124-16129 NNS denotes cells
T9233 16117-16123 NN denotes glioma
T9232 16114-16116 IN denotes in
T9231 16110-16113 NNP denotes TMZ
T9230 16107-16109 TO denotes to
T9229 16095-16106 NN denotes sensitivity
T9228 16087-16094 VBZ denotes confers
T9227 16083-16086 NN denotes p53
T9226 16072-16082 JJ denotes functional
T9225 16069-16071 IN denotes of
T9224 16064-16068 NN denotes Loss
T9223 16062-16063 . denotes .
T9222 16061-16062 -RRB- denotes )
T9221 16057-16061 CD denotes 2011
T9220 16055-16056 , denotes ,
T9219 16052-16055 FW denotes al.
T9218 16049-16051 FW denotes et
T9217 16042-16048 NNP denotes Blough
T9216 16040-16041 : denotes ;
T9215 16036-16040 CD denotes 2010
T9214 16034-16035 , denotes ,
T9213 16031-16034 FW denotes al.
T9212 16028-16030 FW denotes et
T9211 16018-16027 NNP denotes Squatrito
T9210 16016-16017 : denotes ;
T9209 16012-16016 CD denotes 2001
T9208 16010-16011 , denotes ,
T9207 16007-16010 FW denotes al.
T9206 16004-16006 FW denotes et
T9205 15997-16003 NNP denotes Hirose
T9204 15995-15996 : denotes ;
T9203 15991-15995 CD denotes 1995
T9202 15989-15990 , denotes ,
T9201 15986-15989 FW denotes al.
T9200 15983-15985 FW denotes et
T9199 15975-15982 NNP denotes Gjerset
T9198 15974-15975 -LRB- denotes (
T9197 15968-15973 NNS denotes cells
T9196 15961-15967 NN denotes glioma
T9195 15958-15960 IN denotes in
T9194 15948-15957 NN denotes treatment
T9193 15944-15947 NNP denotes TMZ
T9192 15940-15943 CC denotes and
T9191 15927-15939 JJ denotes radiotherapy
T9190 15924-15926 IN denotes in
T9189 15910-15923 NN denotes effectiveness
T9188 15906-15909 DT denotes the
T9187 15902-15905 IN denotes for
T9186 15894-15901 NNS denotes factors
T9185 15882-15893 JJ denotes unfavorable
T9184 15879-15881 IN denotes as
T9183 15868-15878 VBN denotes considered
T9182 15864-15867 VBP denotes are
T9181 15856-15863 NNS denotes mutants
T9180 15852-15855 NN denotes p53
T9331 16645-16648 VBZ denotes has
T9330 16640-16644 NNP denotes WWOX
T9329 16632-16639 JJ denotes ectopic
T9328 16630-16631 , denotes ,
T9327 16623-16630 RB denotes However
T9326 16621-16622 . denotes .
T9325 16620-16621 -RRB- denotes )
T9324 16616-16620 CD denotes 2012
T9323 16614-16615 , denotes ,
T9322 16611-16614 FW denotes al.
T9321 16608-16610 FW denotes et
T9320 16601-16607 NNP denotes Chiang
T9319 16600-16601 -LRB- denotes (
T9318 16586-16599 NN denotes fragmentation
T9317 16582-16585 NNP denotes DNA
T9316 16578-16581 CC denotes and
T9315 16567-16577 JJ denotes hypoploidy
T9314 16559-16566 VBG denotes causing
T9313 16556-16558 IN denotes by
T9312 16552-16555 NN denotes p53
T9311 16545-16551 JJ denotes mutant
T9310 16535-16544 VBG denotes harboring
T9309 16529-16534 NNS denotes cells
T9308 16521-16528 NN denotes U373-MG
T9307 16508-16520 NN denotes glioblastoma
T9306 16505-16507 IN denotes of
T9305 16495-16504 NN denotes apoptosis
T9304 16487-16494 VBZ denotes induces
T9303 16482-16486 NNP denotes WWOX
T9302 16468-16481 VBN denotes overexpressed
T9301 16463-16467 IN denotes that
T9300 16450-16462 VBD denotes demonstrated
T9299 16447-16449 PRP denotes we
T9298 16445-16446 , denotes ,
T9297 16437-16445 RB denotes Recently
T9296 16435-16436 . denotes .
T9295 16434-16435 -RRB- denotes )
T9294 16430-16434 CD denotes 2011
T9293 16428-16429 , denotes ,
T9292 16425-16428 FW denotes al.
T9291 16422-16424 FW denotes et
T9290 16416-16421 NNP denotes Kosla
T9289 16415-16416 -LRB- denotes (
T9288 16403-16414 NN denotes methylation
T9287 16394-16402 NN denotes promoter
T9286 16390-16393 CC denotes and
T9285 16375-16389 NN denotes heterozygosity
T9284 16372-16374 IN denotes of
T9283 16367-16371 NN denotes loss
T9282 16362-16366 IN denotes with
T9281 16351-16361 VBN denotes associated
T9280 16348-16350 VBZ denotes is
T9279 16343-16347 NNP denotes WWOX
T9278 16340-16342 IN denotes of
T9277 16325-16339 NN denotes downregulation
T9276 16319-16324 WDT denotes which
T9275 16316-16318 IN denotes in
T9274 16314-16315 , denotes ,
T9273 16310-16314 NNS denotes GBMs
T9272 16307-16309 IN denotes in
T9271 16301-16306 VBN denotes shown
T7999 14903-14905 TO denotes to
T7998 14899-14902 JJ denotes due
T7997 14888-14898 VBN denotes identified
T7996 14883-14887 VBN denotes been
T7995 14878-14882 VBP denotes have
T7994 14874-14877 NN denotes p53
T7993 14871-14873 IN denotes of
T7992 14862-14870 NNS denotes isoforms
T7991 14857-14861 CD denotes nine
T7990 14851-14856 JJS denotes least
T7989 14848-14850 IN denotes At
T8169 15816-15817 . denotes .
T8168 15807-15816 NN denotes apoptosis
T8167 15804-15806 IN denotes as
T8166 15799-15803 RB denotes well
T8165 15796-15798 RB denotes as
T8164 15794-15795 , denotes ,
T8163 15785-15794 NNS denotes promoters
T8162 15781-15784 NNP denotes Bax
T8161 15777-15780 CC denotes and
T8160 15773-15776 CD denotes p21
T8159 15770-15772 IN denotes on
T8158 15761-15769 NN denotes activity
T8157 15745-15760 JJ denotes transcriptional
T8156 15741-15744 NN denotes p53
T8155 15734-15740 VB denotes affect
T8154 15730-15733 RB denotes not
T8153 15725-15729 VBZ denotes does
T8152 15721-15724 NN denotes p53
T8151 15716-15720 IN denotes with
T8150 15707-15715 NNP denotes Δ133p53γ
T8149 15704-15706 CC denotes or
T8148 15695-15703 NNP denotes Δ133p53β
T8147 15692-15694 IN denotes of
T8146 15678-15691 NN denotes Co-expression
T8145 15676-15677 . denotes .
T8144 15675-15676 -RRB- denotes )
T8143 15671-15675 CD denotes 2011
T8142 15669-15670 , denotes ,
T8141 15666-15669 FW denotes al.
T8140 15663-15665 FW denotes et
T8139 15655-15662 NNP denotes Aoubala
T8138 15654-15655 -LRB- denotes (
T8137 15646-15653 NNS denotes manners
T8136 15634-15645 JJ denotes independent
T8135 15633-15634 : denotes -
T8134 15629-15632 CC denotes and
T8133 15615-15628 JJ denotes p53-dependent
T8132 15612-15614 IN denotes in
T8131 15601-15611 NN denotes expression
T8130 15596-15600 NN denotes gene
T8129 15586-15595 VBZ denotes regulates
T8128 15571-15585 RB denotes differentially
T8127 15563-15570 JJ denotes Δ133p53
T8126 15561-15562 . denotes .
T8125 15560-15561 -RRB- denotes )
T8124 15556-15560 CD denotes 2005
T8123 15554-15555 , denotes ,
T8122 15551-15554 FW denotes al.
T8121 15548-15550 FW denotes et
T8120 15540-15547 NNP denotes Bourdon
T8119 15539-15540 -LRB- denotes (
T8118 15529-15538 NN denotes apoptosis
T8117 15516-15528 JJ denotes p53-mediated
T8116 15505-15515 NNS denotes suppresses
T8115 15497-15504 JJ denotes Δ133p53
T8114 15492-15496 IN denotes with
T8113 15488-15491 NN denotes p53
T8112 15485-15487 IN denotes of
T8111 15471-15484 NN denotes co-expression
T8110 15463-15470 IN denotes whereas
T8109 15461-15462 , denotes ,
T8108 15452-15461 NN denotes apoptosis
T8107 15439-15451 JJ denotes p53-mediated
T8106 15429-15438 NNS denotes increases
T8105 15424-15428 JJ denotes p53β
T8104 15420-15423 CC denotes and
T8103 15416-15419 NN denotes p53
T8102 15413-15415 IN denotes of
T8101 15397-15412 NN denotes Co-transfection
T8100 15395-15396 . denotes .
T8099 15394-15395 -RRB- denotes )
T8098 15390-15394 CD denotes 2005
T8097 15388-15389 , denotes ,
T8096 15385-15388 FW denotes al.
T8095 15382-15384 FW denotes et
T8094 15374-15381 NNP denotes Bourdon
T8093 15373-15374 -LRB- denotes (
T8092 15363-15372 NN denotes cytoplasm
T8091 15359-15362 DT denotes the
T8090 15356-15358 IN denotes in
T8089 15346-15355 VBN denotes localized
T8088 15343-15345 VBZ denotes is
T8087 15334-15342 NNP denotes Δ133p53γ
T8086 15332-15333 . denotes .
T8085 15323-15332 NN denotes cytoplasm
T8084 15319-15322 CC denotes and
T8083 15311-15318 NN denotes nucleus
T8082 15307-15310 DT denotes the
T8081 15304-15306 IN denotes in
T8080 15294-15303 VBN denotes localized
T8079 15290-15293 VBP denotes are
T8078 15281-15289 NNP denotes Δ133p53β
T8077 15277-15280 CC denotes and
T8076 15272-15276 CD denotes p53γ
T8075 15270-15271 . denotes .
T8074 15261-15270 NN denotes cytoplasm
T8073 15258-15260 IN denotes in
T8072 15254-15257 VBP denotes are
T8071 15249-15253 PRP denotes them
T8070 15246-15248 IN denotes of
T8069 15242-15245 JJ denotes few
T8068 15237-15241 RB denotes only
T8067 15233-15236 CC denotes and
T8066 15231-15232 , denotes ,
T8065 15224-15231 NN denotes nucleus
T8064 15220-15223 DT denotes the
T8063 15217-15219 IN denotes in
T8062 15210-15216 RB denotes mainly
T8061 15200-15209 VBN denotes localized
T8060 15196-15199 VBP denotes are
T8059 15191-15195 CD denotes p53β
T8058 15187-15190 CC denotes and
T8057 15185-15186 , denotes ,
T8056 15178-15185 NNP denotes Δ133p53
T8055 15176-15177 , denotes ,
T8054 15173-15176 NN denotes p53
T8053 15161-15172 JJ denotes Full-length
T8052 15159-15160 . denotes .
T8051 15158-15159 -RRB- denotes )
T8050 15154-15158 CD denotes 2007
T8049 15152-15153 , denotes ,
T8048 15145-15152 NNP denotes Bourdon
T8047 15143-15144 : denotes ;
T8046 15139-15143 CD denotes 2005
T8045 15137-15138 , denotes ,
T8044 15134-15137 FW denotes al.
T8043 15131-15133 FW denotes et
T8042 15123-15130 NNP denotes Bourdon
T8041 15122-15123 -LRB- denotes (
T8040 15111-15121 RB denotes frequently
T8039 15104-15110 VBZ denotes occurs
T8038 15095-15103 NNS denotes isoforms
T8037 15091-15094 NN denotes p53
T8036 15088-15090 IN denotes of
T8035 15077-15087 NN denotes expression
T8034 15068-15076 JJ denotes aberrant
T8033 15066-15067 , denotes ,
T8032 15059-15066 NNS denotes cancers
T8031 15056-15058 IN denotes In
T8030 15054-15055 . denotes .
T8029 15053-15054 -RRB- denotes )
T8028 15052-15053 CD denotes 2
T8027 15045-15051 NN denotes Figure
T8026 15043-15044 : denotes ;
T8025 15039-15043 CD denotes 2006
T8024 15037-15038 , denotes ,
T8023 15034-15037 FW denotes al.
T8022 15031-15033 FW denotes et
T8021 15027-15030 NNP denotes Ray
T8020 15025-15026 : denotes ;
T8019 15021-15025 CD denotes 2004
T8018 15019-15020 , denotes ,
T8017 15016-15019 FW denotes al.
T8016 15013-15015 FW denotes et
T8015 15007-15012 NNP denotes Ghosh
T8014 15006-15007 -LRB- denotes (
T8013 14994-15005 NN denotes translation
T8012 14991-14993 IN denotes of
T8011 14985-14990 NNS denotes sites
T8010 14974-14984 NN denotes initiation
T8009 14962-14973 JJ denotes alternative
T8008 14958-14961 CC denotes and
T8007 14956-14957 , denotes ,
T8006 14947-14956 NNS denotes promoters
T8005 14942-14946 NN denotes gene
T8004 14933-14941 JJ denotes multiple
T8003 14931-14932 , denotes ,
T8002 14923-14931 NN denotes splicing
T8001 14918-14922 NNP denotes mRNA
T8000 14906-14917 JJ denotes alternative
T7320 13708-13709 . denotes .
T7319 13702-13708 NNS denotes others
T7318 13697-13701 JJ denotes many
T7317 13693-13696 CC denotes and
T7316 13691-13692 , denotes ,
T7315 13690-13691 -RRB- denotes )
T7314 13686-13690 CD denotes 1999
T7313 13684-13685 , denotes ,
T7312 13681-13684 FW denotes al.
T7311 13678-13680 FW denotes et
T7310 13674-13677 NNP denotes Sun
T7309 13673-13674 -LRB- denotes (
T7298 13628-13633 NNP denotes Comer
T7297 13627-13628 -LRB- denotes (
T7296 13619-13626 NN denotes α-actin
T7295 13612-13618 NN denotes muscle
T7294 13605-13611 JJ denotes smooth
T7293 13602-13604 IN denotes of
T7292 13591-13601 NN denotes expression
T7291 13587-13590 DT denotes the
T7290 13576-13586 VBG denotes regulating
T7289 13572-13575 IN denotes via
T7288 13563-13571 NN denotes motility
T7287 13558-13562 NN denotes cell
T7286 13546-13557 VBG denotes controlling
T7285 13543-13545 IN denotes in
T7284 13538-13542 NN denotes role
T7283 13536-13537 DT denotes a
T7282 13530-13535 VBZ denotes plays
T7281 13526-13529 NN denotes p53
T7280 13524-13525 , denotes ,
T7279 13520-13524 RB denotes Also
T7278 13518-13519 . denotes .
T7277 13517-13518 -RRB- denotes )
T7276 13513-13517 CD denotes 2009
T7275 13511-13512 , denotes ,
T7274 13508-13511 FW denotes al.
T7273 13505-13507 FW denotes et
T7272 13496-13504 NNP denotes Menendez
T7271 13495-13496 -LRB- denotes (
T7270 13488-13494 NN denotes damage
T7269 13479-13487 JJ denotes cellular
T7268 13476-13478 IN denotes of
T7267 13469-13475 NN denotes extent
T7266 13465-13468 DT denotes the
T7265 13461-13464 CC denotes and
T7264 13459-13460 , denotes ,
T7263 13453-13459 NN denotes signal
T7262 13446-13452 NN denotes stress
T7261 13442-13445 DT denotes the
T7260 13439-13441 IN denotes of
T7259 13429-13438 NN denotes intensity
T7258 13425-13428 DT denotes the
T7257 13423-13424 , denotes ,
T7256 13418-13423 NNS denotes types
T7255 13413-13417 NN denotes cell
T7254 13408-13412 IN denotes upon
T7253 13398-13407 VBG denotes depending
T7252 13396-13397 , denotes ,
T7251 13388-13396 NN denotes response
T7250 13382-13387 NN denotes death
T7249 13377-13381 NN denotes cell
T7248 13374-13376 CC denotes or
T7247 13361-13373 JJ denotes pro-survival
T7246 13352-13360 VBZ denotes triggers
T7245 13348-13351 NN denotes p53
T7244 13346-13347 . denotes .
T7243 13345-13346 -RRB- denotes )
T7242 13341-13345 CD denotes 2010
T7241 13339-13340 , denotes ,
T7240 13333-13339 NNP denotes Levine
T7239 13329-13332 CC denotes and
T7238 13324-13328 NNP denotes Lane
T7237 13323-13324 -LRB- denotes (
T7236 13317-13322 NN denotes BCL-2
T7235 13312-13316 NN denotes gene
T7234 13298-13311 JJ denotes antiapoptotic
T7233 13294-13297 DT denotes the
T7232 13283-13293 VBG denotes inhibiting
T7231 13279-13282 CC denotes and
T7230 13277-13278 , denotes ,
T7229 13274-13277 NNP denotes FAS
T7228 13270-13273 CC denotes and
T7227 13268-13269 , denotes ,
T7226 13262-13268 NNP denotes SCOTIN
T7225 13260-13261 , denotes ,
T7224 13256-13260 NNP denotes PUMA
T7223 13254-13255 , denotes ,
T7222 13251-13254 NNP denotes BAX
T7221 13248-13250 IN denotes as
T7220 13243-13247 JJ denotes such
T7219 13237-13242 NNS denotes genes
T7218 13224-13236 JJ denotes proapoptotic
T7217 13208-13223 VBG denotes transactivating
T7216 13205-13207 IN denotes by
T7215 13195-13204 NN denotes apoptosis
T7214 13187-13194 VBZ denotes induces
T7213 13183-13186 NN denotes p53
T7212 13181-13182 . denotes .
T7211 13176-13181 NNP denotes miR34
T7210 13167-13175 NNP denotes microRNA
T7209 13164-13166 CC denotes or
T7208 13162-13163 , denotes ,
T7207 13159-13162 CD denotes p21
T7206 13149-13158 NN denotes inhibitor
T7205 13142-13148 NN denotes kinase
T7204 13125-13141 JJ denotes cyclin-dependent
T7203 13122-13124 IN denotes as
T7202 13117-13121 JJ denotes such
T7201 13111-13116 NNS denotes genes
T7200 13095-13110 VBG denotes transactivating
T7199 13092-13094 IN denotes by
T7198 13085-13091 NN denotes arrest
T7197 13079-13084 NN denotes cycle
T7196 13074-13078 NN denotes cell
T7195 13066-13073 VBZ denotes induces
T7194 13062-13065 NN denotes p53
T7193 13060-13061 . denotes .
T7192 13059-13060 -RRB- denotes )
T7191 13058-13059 CD denotes 2
T7190 13051-13057 NN denotes Figure
T7189 13050-13051 -LRB- denotes (
T7188 13041-13049 VBN denotes depicted
T7187 13037-13040 VBP denotes are
T7186 13028-13036 NNS denotes isoforms
T7185 13024-13027 PRP$ denotes its
T7184 13020-13023 CC denotes and
T7183 13016-13019 NN denotes p53
T7182 13013-13015 IN denotes of
T7181 13002-13012 NNS denotes structures
T7180 12994-13001 JJ denotes primary
T7179 12990-12993 DT denotes The
T7178 12988-12989 . denotes .
T7177 12987-12988 -RRB- denotes )
T7176 12983-12987 CD denotes 2010
T7175 12981-12982 , denotes ,
T7174 12975-12981 NNP denotes Levine
T7173 12971-12974 CC denotes and
T7172 12966-12970 NNP denotes Lane
T7171 12965-12966 -LRB- denotes (
T7170 12954-12964 NN denotes metabolism
T7169 12951-12953 CC denotes or
T7168 12949-12950 , denotes ,
T7167 12943-12949 NN denotes repair
T7166 12939-12942 NNP denotes DNA
T7165 12937-12938 , denotes ,
T7164 12927-12937 NN denotes senescence
T7163 12925-12926 , denotes ,
T7162 12919-12925 NN denotes arrest
T7161 12913-12918 NN denotes cycle
T7160 12908-12912 NN denotes cell
T7159 12906-12907 , denotes ,
T7158 12897-12906 NN denotes apoptosis
T7157 12888-12896 NNS denotes mediates
T7156 12884-12887 NN denotes p53
T7155 12874-12883 VBN denotes Activated
T7308 13668-13672 NNP denotes VIα1
T7307 13664-13667 CC denotes and
T7306 13659-13663 NNP denotes IIα1
T7305 13649-13658 VBZ denotes collagens
T7304 13647-13648 , denotes ,
T7303 13646-13647 -RRB- denotes )
T7302 13642-13646 CD denotes 1998
T7301 13640-13641 , denotes ,
T7300 13637-13640 FW denotes al.
T7299 13634-13636 FW denotes et
T6644 12843-12846 FW denotes al.
T6643 12840-12842 FW denotes et
T6642 12836-12839 NNP denotes Hsu
T6641 12835-12836 -LRB- denotes (
T6640 12826-12834 NN denotes activity
T6639 12817-12825 NN denotes promoter
T6638 12805-12816 JJ denotes SMAD-driven
T6637 12801-12804 DT denotes the
T6636 12791-12800 VBG denotes enhancing
T6635 12787-12790 IN denotes for
T6634 12779-12786 NN denotes nucleus
T6633 12775-12778 DT denotes the
T6632 12772-12774 TO denotes to
T6631 12763-12771 VB denotes relocate
T6630 12760-12762 TO denotes to
T6629 12752-12759 NN denotes complex
T6628 12746-12751 NNP denotes Smad4
T6627 12745-12746 CD denotes /
T6626 12743-12745 CD denotes -2
T6625 12734-12743 NNP denotes WWOX/Hyal
T6624 12730-12733 DT denotes the
T6623 12727-12729 IN denotes of
T6622 12717-12726 NN denotes formation
T6621 12713-12716 DT denotes the
T6620 12706-12712 VB denotes signal
T6619 12703-12705 TO denotes to
T6618 12694-12702 NN denotes receptor
T6617 12686-12693 NN denotes cognate
T6616 12684-12685 DT denotes a
T6615 12681-12683 IN denotes as
T6614 12674-12680 JJ denotes Hyal-2
T6613 12668-12673 NNS denotes binds
T6612 12665-12667 CD denotes β1
T6611 12658-12664 NN denotes factor
T6610 12651-12657 NN denotes growth
T6609 12638-12650 VBG denotes Transforming
T6608 12636-12637 . denotes .
T6607 12635-12636 -RRB- denotes )
T6606 12631-12635 CD denotes 2006
T6605 12629-12630 , denotes ,
T6604 12626-12629 FW denotes al.
T6603 12623-12625 FW denotes et
T6602 12619-12622 NNP denotes Jin
T6601 12618-12619 -LRB- denotes (
T6600 12604-12617 NNP denotes Phospho-Ezrin
T6599 12600-12603 CC denotes and
T6598 12598-12599 -RRB- denotes )
T6597 12594-12598 CD denotes 2009
T6596 12592-12593 , denotes ,
T6595 12589-12592 FW denotes al.
T6594 12586-12588 FW denotes et
T6593 12582-12585 NNP denotes Hsu
T6592 12581-12582 -LRB- denotes (
T6591 12574-12580 NN denotes Hyal-2
T6590 12560-12573 NN denotes hyaluronidase
T6589 12555-12559 IN denotes with
T6588 12547-12554 JJ denotes binding
T6587 12543-12546 IN denotes via
T6586 12538-12542 NN denotes area
T6585 12516-12537 JJ denotes membrane/cytoskeleton
T6584 12512-12515 DT denotes the
T6583 12509-12511 IN denotes in
T6582 12500-12508 VBN denotes anchored
T6581 12497-12499 VBZ denotes is
T6580 12492-12496 NNP denotes WWOX
T6579 12489-12491 IN denotes of
T6578 12481-12488 NN denotes portion
T6577 12479-12480 DT denotes A
T6576 12477-12478 . denotes .
T6575 12476-12477 -RRB- denotes )
T6574 12472-12476 CD denotes 2009
T6573 12470-12471 , denotes ,
T6572 12467-12470 FW denotes al.
T6571 12464-12466 FW denotes et
T6570 12459-12463 NNP denotes Hong
T6569 12458-12459 -LRB- denotes (
T6568 12450-12457 NN denotes pathway
T6567 12439-12449 NN denotes activation
T6566 12428-12438 VBP denotes complement
T6565 12418-12427 JJ denotes classical
T6564 12414-12417 DT denotes the
T6563 12411-12413 IN denotes of
T6562 12397-12410 RB denotes independently
T6561 12387-12396 NN denotes apoptosis
T6560 12382-12386 NN denotes cell
T6559 12379-12381 TO denotes to
T6558 12373-12378 VBZ denotes leads
T6557 12369-12372 CC denotes and
T6556 12363-12368 NNP denotes Try33
T6555 12360-12362 IN denotes in
T6554 12344-12359 NN denotes phosphorylation
T6553 12339-12343 NNP denotes WWOX
T6552 12331-12338 JJ denotes ectopic
T6551 12323-12330 VBZ denotes induces
T6550 12319-12322 NN denotes C1q
T6549 12308-12318 NN denotes Complement
T6548 12306-12307 . denotes .
T6547 12305-12306 -RRB- denotes )
T6546 12300-12305 JJ denotes 2012a
T6545 12298-12299 , denotes ,
T6544 12295-12298 FW denotes al.
T6543 12292-12294 FW denotes et
T6542 12286-12291 NNP denotes Zhang
T6541 12285-12286 -LRB- denotes (
T6540 12272-12284 NN denotes mitochondria
T6539 12268-12271 DT denotes the
T6538 12263-12267 IN denotes from
T6537 12253-12262 VBG denotes releasing
T6536 12251-12252 NNP denotes C
T6535 12240-12250 NN denotes cytochrome
T6534 12232-12239 VBZ denotes induces
T6533 12228-12231 CC denotes and
T6532 12217-12227 NN denotes activation
T6531 12204-12216 JJ denotes procaspase-9
T6530 12200-12203 CC denotes and
T6529 12187-12199 JJ denotes procaspase-3
T6528 12179-12186 VBZ denotes induces
T6527 12173-12178 NNS denotes cells
T6526 12168-12172 NNP denotes A549
T6525 12165-12167 IN denotes in
T6524 12160-12164 NNP denotes WWOX
T6523 12157-12159 IN denotes of
T6522 12146-12156 NN denotes expression
T6521 12138-12145 JJ denotes Ectopic
T6520 12136-12137 . denotes .
T6519 12135-12136 -RRB- denotes )
T6518 12131-12135 CD denotes 2012
T6517 12129-12130 , denotes ,
T6516 12126-12129 FW denotes al.
T6515 12123-12125 FW denotes et
T6514 12118-12122 NNP denotes Holt
T6513 12117-12118 -LRB- denotes (
T6512 12110-12116 NN denotes growth
T6511 12105-12109 NN denotes cell
T6510 12098-12104 NN denotes cancer
T6509 12095-12097 IN denotes of
T6508 12083-12094 NN denotes suppression
T6507 12071-12082 JJ denotes TMZ-induced
T6506 12061-12070 VBZ denotes increases
T6505 12052-12060 NN denotes activity
T6504 12048-12051 NNP denotes MEK
T6503 12045-12047 IN denotes of
T6502 12034-12044 NNP denotes Inhibition
T6501 12032-12033 . denotes .
T6500 12028-12032 NN denotes raft
T6499 12022-12027 JJ denotes lipid
T6498 12018-12021 DT denotes the
T6497 12015-12017 TO denotes to
T6496 12005-12014 VBZ denotes relocates
T6495 12001-12004 NNP denotes MEK
T6494 11993-12000 IN denotes whereas
T6493 11991-11992 , denotes ,
T6492 11982-11991 NN denotes apoptosis
T6491 11975-11981 VB denotes induce
T6490 11972-11974 TO denotes to
T6489 11959-11971 NN denotes mitochondria
T6488 11955-11958 DT denotes the
T6487 11952-11954 TO denotes to
T6486 11940-11951 VB denotes translocate
T6485 11937-11939 TO denotes to
T6484 11932-11936 NNP denotes WWOX
T6483 11924-11931 VBZ denotes induces
T6482 11920-11923 CC denotes and
T6481 11912-11919 NN denotes complex
T6480 11903-11911 NNP denotes MEK/WWOX
T6479 11899-11902 DT denotes the
T6478 11887-11898 VBZ denotes dissociates
T6477 11885-11886 -RRB- denotes )
T6476 11882-11885 NNP denotes PMA
T6475 11881-11882 -LRB- denotes (
T6474 11873-11880 NN denotes acetate
T6473 11863-11872 NN denotes myristate
T6472 11855-11862 NNP denotes Phorbol
T6471 11853-11854 . denotes .
T6470 11852-11853 -RRB- denotes )
T6469 11848-11852 CD denotes 2011
T6468 11846-11847 , denotes ,
T6467 11843-11846 FW denotes al.
T6466 11840-11842 FW denotes et
T6465 11836-11839 NNP denotes Lin
T6464 11835-11836 -LRB- denotes (
T6463 11829-11834 NNS denotes cells
T6462 11827-11828 NNP denotes T
T6461 11820-11826 NNP denotes Jurkat
T6460 11817-11819 IN denotes in
T6459 11813-11816 NNP denotes MEK
T6458 11807-11812 VBZ denotes binds
T6457 11802-11806 NNP denotes WWOX
T6456 11800-11801 . denotes .
T6455 11799-11800 -RRB- denotes )
T6454 11795-11799 CD denotes 2010
T6453 11793-11794 , denotes ,
T6452 11789-11793 CD denotes 2007
T6451 11787-11788 , denotes ,
T6450 11784-11787 FW denotes al.
T6449 11781-11783 FW denotes et
T6448 11775-11780 NNP denotes Chang
T6447 11774-11775 -LRB- denotes (
T6446 11764-11773 NN denotes apoptosis
T6445 11755-11763 VBG denotes inducing
T6444 11751-11754 IN denotes for
T6443 11744-11750 NN denotes nuclei
T6442 11741-11743 CC denotes or
T6441 11728-11740 NN denotes mitochondria
T6440 11725-11727 TO denotes to
T6439 11714-11724 VBG denotes relocating
T6438 11711-11713 IN denotes by
T6437 11702-11710 VBN denotes followed
T6436 11700-11701 , denotes ,
T6435 11695-11700 NNS denotes sites
T6434 11688-11694 NNS denotes others
T6433 11679-11687 RB denotes probably
T6432 11675-11678 CC denotes and
T6431 11669-11674 NNP denotes Tyr33
T6430 11666-11668 IN denotes in
T6429 11650-11665 NN denotes phosphorylation
T6426 11633-11634 , denotes ,
T6425 11628-11633 NNS denotes drugs
T6424 11611-11627 JJ denotes chemotherapeutic
T6423 11607-11610 CC denotes and
T6422 11595-11606 NN denotes irradiation
T6421 11592-11594 NNP denotes UV
T6420 11589-11591 IN denotes as
T6419 11584-11588 JJ denotes such
T6418 11582-11583 , denotes ,
T6417 11576-11582 NN denotes stress
T6416 11562-11575 JJ denotes environmental
T6415 11559-11561 CC denotes or
T6414 11549-11558 NNS denotes chemicals
T6413 11546-11548 TO denotes to
T6412 11537-11545 NN denotes exposure
T6411 11532-11536 IN denotes Upon
T6410 11530-11531 . denotes .
T6409 11527-11530 NN denotes p53
T6408 11522-11526 IN denotes with
T6407 11506-11521 RB denotes synergistically
T6406 11500-11505 NN denotes death
T6405 11495-11499 NN denotes cell
T6404 11486-11494 VBZ denotes mediates
T6403 11481-11485 NNP denotes WWOX
T6402 11479-11480 , denotes ,
T6401 11475-11479 RB denotes Also
T6400 11473-11474 . denotes .
T6399 11472-11473 -RRB- denotes )
T6398 11468-11472 CD denotes 2001
T6397 11466-11467 , denotes ,
T6396 11463-11466 FW denotes al.
T6395 11460-11462 FW denotes et
T6394 11454-11459 NNP denotes Chang
T6393 11453-11454 -LRB- denotes (
T6392 11449-11452 NN denotes p53
T6391 11439-11448 JJ denotes apoptotic
T6390 11425-11438 JJ denotes up-regulating
T6389 11421-11424 CC denotes and
T6388 11414-11420 JJ denotes Bcl-xL
T6387 11410-11413 CC denotes and
T6386 11404-11409 NN denotes Bcl-2
T6385 11394-11403 NN denotes inhibitor
T6384 11384-11393 NN denotes apoptosis
T6383 11368-11383 JJ denotes down-regulating
T6382 11365-11367 IN denotes by
T6381 11358-11364 NN denotes factor
T6380 11349-11357 NN denotes necrosis
T6379 11343-11348 NN denotes tumor
T6378 11340-11342 IN denotes of
T6377 11331-11339 NN denotes function
T6376 11321-11330 JJ denotes cytotoxic
T6375 11317-11320 DT denotes the
T6374 11308-11316 VBZ denotes enhances
T6373 11303-11307 NNP denotes WWOX
T6648 12853-12854 . denotes .
T6647 12852-12853 -RRB- denotes )
T6646 12848-12852 CD denotes 2009
T6645 12846-12847 , denotes ,
T6372 11301-11302 . denotes .
T6371 11300-11301 -RRB- denotes )
T6370 11296-11300 CD denotes 2012
T6369 11294-11295 , denotes ,
T6368 11291-11294 FW denotes al.
T6367 11288-11290 FW denotes et
T6366 11285-11287 NNP denotes Su
T6365 11283-11284 : denotes ;
T6364 11279-11283 CD denotes 2012
T6363 11277-11278 , denotes ,
T6362 11274-11277 FW denotes al.
T6361 11271-11273 FW denotes et
T6360 11265-11270 NNP denotes Salah
T6359 11263-11264 : denotes ;
T6358 11259-11263 CD denotes 2010
T6357 11257-11258 , denotes ,
T6356 11253-11257 CD denotes 2007
T6355 11251-11252 , denotes ,
T6354 11248-11251 FW denotes al.
T6353 11245-11247 FW denotes et
T6352 11239-11244 NNP denotes Chang
T6351 11238-11239 -LRB- denotes (
T6350 11232-11237 NNS denotes types
T6349 11227-11231 NN denotes cell
T6348 11220-11226 NN denotes cancer
T6347 11215-11219 JJ denotes many
T6346 11211-11214 CC denotes and
T6345 11209-11210 -RRB- denotes )
T6344 11205-11209 CD denotes 2012
T6343 11203-11204 , denotes ,
T6342 11200-11203 FW denotes al.
T6341 11197-11199 FW denotes et
T6340 11194-11196 NNP denotes Hu
T6339 11193-11194 -LRB- denotes (
T6338 11187-11192 NNS denotes cells
T6337 11177-11186 NN denotes carcinoma
T6336 11169-11176 JJ denotes hepatic
T6335 11163-11168 JJ denotes human
T6334 11160-11162 IN denotes of
T6333 11146-11159 NN denotes proliferation
T6332 11137-11145 NNS denotes inhibits
T6331 11133-11136 CC denotes and
T6330 11123-11132 NN denotes apoptosis
T6329 11115-11122 VBZ denotes induces
T6328 11110-11114 NNP denotes WWOX
T6327 11096-11109 NNP denotes Overexpressed
T6326 11094-11095 . denotes .
T6325 11093-11094 -RRB- denotes )
T6324 11089-11093 CD denotes 2009
T6323 11087-11088 , denotes ,
T6322 11084-11087 FW denotes al.
T6321 11081-11083 FW denotes et
T6320 11071-11080 NNP denotes Bouteille
T6319 11070-11071 -LRB- denotes (
T6318 11061-11069 NN denotes activity
T6317 11045-11060 JJ denotes transcriptional
T6316 11041-11044 NNP denotes TCF
T6315 11026-11040 JJ denotes Dvl-2-mediated
T6314 11019-11025 NNS denotes blocks
T6313 11011-11018 RB denotes thereby
T6312 11007-11010 CC denotes and
T6311 10997-11006 NN denotes cytoplasm
T6310 10993-10996 DT denotes the
T6309 10990-10992 IN denotes in
T6308 10984-10989 NN denotes Dvl-2
T6307 10973-10983 NNS denotes sequesters
T6306 10968-10972 NNP denotes WWOX
T6305 10954-10967 VBN denotes overexpressed
T6304 10942-10953 RB denotes Transiently
T6303 10940-10941 . denotes .
T6302 10937-10940 NNP denotes Dvl
T6301 10934-10936 IN denotes in
T6300 10931-10933 VBZ denotes is
T6299 10925-10930 NN denotes motif
T6298 10920-10924 NN denotes PPxY
T6297 10917-10919 DT denotes No
T6296 10915-10916 . denotes .
T6295 10914-10915 -RRB- denotes )
T6294 10913-10914 CD denotes 1
T6293 10906-10912 NN denotes Figure
T6292 10905-10906 -LRB- denotes (
T6291 10897-10904 NN denotes pathway
T6290 10887-10896 VBG denotes signaling
T6289 10877-10886 JJ denotes β-catenin
T6288 10876-10877 NNP denotes /
T6287 10873-10876 NNP denotes Wnt
T6286 10870-10872 IN denotes in
T6285 10859-10869 NNS denotes components
T6284 10855-10858 JJ denotes key
T6283 10851-10854 VBP denotes are
T6282 10845-10850 WDT denotes which
T6281 10843-10844 , denotes ,
T6280 10842-10843 -RRB- denotes )
T6279 10839-10842 NNP denotes Dvl
T6278 10838-10839 -LRB- denotes (
T6277 10829-10837 NNS denotes proteins
T6276 10818-10828 JJ denotes Disheveled
T6275 10812-10817 VBZ denotes binds
T6274 10807-10811 NNP denotes WWOX
T6273 10805-10806 , denotes ,
T6272 10801-10805 RB denotes Also
T6271 10799-10800 . denotes .
T6270 10798-10799 -RRB- denotes )
T6269 10793-10798 JJ denotes 2005b
T6268 10791-10792 , denotes ,
T6267 10788-10791 FW denotes al.
T6266 10785-10787 FW denotes et
T6265 10779-10784 NNP denotes Chang
T6264 10778-10779 -LRB- denotes (
T6263 10769-10777 NN denotes function
T6262 10759-10768 JJ denotes apoptotic
T6261 10755-10758 PRP$ denotes its
T6260 10751-10754 CC denotes and
T6259 10747-10750 NN denotes p53
T6258 10736-10746 VBZ denotes stabilizes
T6257 10730-10735 WDT denotes which
T6256 10728-10729 , denotes ,
T6255 10727-10728 -RRB- denotes )
T6254 10726-10727 CD denotes 1
T6253 10719-10725 NN denotes Figure
T6252 10718-10719 -LRB- denotes (
T6251 10714-10717 NN denotes p53
T6250 10696-10713 JJ denotes 46-phosphorylated
T6249 10689-10695 NN denotes serine
T6248 10684-10688 IN denotes with
T6247 10674-10683 VBZ denotes interacts
T6246 10663-10673 RB denotes physically
T6245 10658-10662 NNP denotes WWOX
T6244 10648-10657 VBN denotes Activated
T6243 10646-10647 . denotes .
T6242 10645-10646 -RRB- denotes )
T6241 10641-10645 CD denotes 2010
T6240 10639-10640 , denotes ,
T6239 10635-10639 CD denotes 2007
T6238 10633-10634 , denotes ,
T6237 10632-10633 NN denotes b
T6236 10631-10632 , denotes ,
T6235 10626-10631 CD denotes 2005a
T6234 10624-10625 , denotes ,
T6233 10620-10624 CD denotes 2003
T6232 10618-10619 , denotes ,
T6231 10614-10618 CD denotes 2001
T6230 10612-10613 , denotes ,
T6229 10609-10612 FW denotes al.
T6228 10606-10608 FW denotes et
T6227 10600-10605 NNP denotes Chang
T6226 10599-10600 -LRB- denotes (
T6225 10593-10598 NN denotes motif
T6224 10588-10592 NNP denotes PPxY
T6223 10584-10587 DT denotes the
T6222 10581-10583 IN denotes of
T6221 10567-10580 RB denotes independently
T6220 10558-10566 NNS denotes proteins
T6219 10552-10557 VBZ denotes binds
T6218 10548-10551 CC denotes and
T6217 10546-10547 , denotes ,
T6216 10541-10546 NNP denotes Tyr33
T6215 10538-10540 IN denotes at
T6214 10522-10537 NN denotes phosphorylation
T6213 10518-10521 IN denotes via
T6212 10508-10517 VBN denotes activated
T6211 10505-10507 VBZ denotes is
T6203 10461-10464 VBD denotes was
T6202 10456-10460 NNP denotes Wwox
T6201 10453-10455 IN denotes by
T6200 10446-10452 NN denotes nuclei
T6199 10442-10445 DT denotes the
T6198 10439-10441 TO denotes to
T6197 10431-10438 NNS denotes factors
T6196 10417-10430 NN denotes transcription
T6195 10414-10416 IN denotes of
T6194 10400-10413 NN denotes translocation
T6193 10397-10399 IN denotes of
T6192 10388-10396 VBG denotes blocking
T6191 10385-10387 DT denotes No
T6190 10383-10384 . denotes .
T6189 10382-10383 -RRB- denotes )
T6188 10378-10382 CD denotes 2009
T6187 10376-10377 , denotes ,
T6186 10373-10376 FW denotes al.
T6185 10370-10372 FW denotes et
T6184 10367-10369 NNP denotes Li
T6183 10366-10367 -LRB- denotes (
T6182 10361-10365 NNS denotes rats
T6181 10358-10360 IN denotes in
T6180 10350-10357 NN denotes axotomy
T6179 10344-10349 NN denotes nerve
T6178 10336-10343 JJ denotes sciatic
T6177 10331-10335 IN denotes upon
T6176 10323-10330 NNS denotes neurons
T6175 10320-10322 IN denotes of
T6174 10313-10319 NN denotes nuclei
T6173 10309-10312 DT denotes the
T6172 10306-10308 TO denotes to
T6171 10298-10305 NNS denotes factors
T6170 10284-10297 NN denotes transcription
T6169 10271-10283 JJ denotes pro-survival
T6168 10267-10270 CC denotes and
T6167 10254-10266 JJ denotes proapoptotic
T6166 10249-10253 IN denotes with
T6165 10237-10248 NNS denotes co-migrates
T6164 10232-10236 NNP denotes Wwox
T6163 10230-10231 , denotes ,
T6162 10222-10230 NN denotes contrast
T6161 10216-10221 JJ denotes stark
T6160 10213-10215 IN denotes In
T6159 10211-10212 . denotes .
T6158 10210-10211 -RRB- denotes )
T6157 10206-10210 CD denotes 2012
T6156 10204-10205 , denotes ,
T6155 10201-10204 FW denotes al.
T6154 10198-10200 FW denotes et
T6153 10192-10197 JJ denotes Salah
T6152 10191-10192 -LRB- denotes (
T6151 10182-10190 NN denotes survival
T6150 10177-10181 NN denotes cell
T6428 11640-11649 VBZ denotes undergoes
T6427 11635-11639 NNP denotes WWOX
T6149 10170-10176 NN denotes cancer
T6148 10159-10169 VBZ denotes suppresses
T6147 10153-10158 WDT denotes which
T6146 10151-10152 , denotes ,
T6145 10146-10151 NN denotes vitro
T6144 10143-10145 IN denotes in
T6143 10132-10142 NN denotes relocation
T6142 10124-10131 JJ denotes nuclear
T6141 10118-10123 PRP$ denotes their
T6140 10112-10117 VB denotes block
T6139 10108-10111 CC denotes and
T6138 10102-10107 NNP denotes c-Jun
T6137 10098-10101 CC denotes and
T6136 10096-10097 , denotes ,
T6135 10093-10096 CD denotes p73
T6134 10091-10092 , denotes ,
T6133 10087-10091 NNP denotes AP-2
T6132 10079-10086 NNS denotes factors
T6131 10065-10078 NN denotes transcription
T6130 10059-10064 VBZ denotes binds
T6129 10054-10058 NNP denotes WWOX
T6128 10040-10053 VBN denotes overexpressed
T6127 10028-10039 RB denotes Transiently
T6126 10026-10027 . denotes .
T6125 10025-10026 -RRB- denotes )
T6124 10024-10025 CD denotes 1
T6123 10017-10023 NN denotes Figure
T6122 10015-10016 : denotes ;
T6121 10011-10015 CD denotes 2012
T6120 10009-10010 , denotes ,
T6119 10006-10009 FW denotes al.
T6118 10003-10005 FW denotes et
T6117 10000-10002 NNP denotes Su
T6116 9998-9999 : denotes ;
T6115 9994-9998 CD denotes 2012
T6114 9992-9993 , denotes ,
T6113 9989-9992 FW denotes al.
T6112 9986-9988 FW denotes et
T6111 9980-9985 NNP denotes Salah
T6110 9978-9979 : denotes ;
T6109 9974-9978 CD denotes 2007
T6108 9972-9973 , denotes ,
T6107 9969-9972 FW denotes al.
T6106 9966-9968 FW denotes et
T6105 9960-9965 NNP denotes Chang
T6104 9959-9960 -LRB- denotes (
T6103 9952-9958 NNS denotes others
T6102 9947-9951 JJ denotes many
T6101 9943-9946 CC denotes and
T6100 9941-9942 , denotes ,
T6099 9936-9941 NNP denotes RUNX4
T6098 9934-9935 , denotes ,
T6097 9929-9934 NNP denotes c-Jun
T6096 9927-9928 , denotes ,
T6095 9921-9927 NNP denotes SIMPLE
T6094 9919-9920 , denotes ,
T6093 9914-9919 NNP denotes Ezrin
T6092 9912-9913 , denotes ,
T6091 9907-9912 JJ denotes ErbB4
T6090 9905-9906 , denotes ,
T6089 9902-9905 JJ denotes p73
T6088 9900-9901 , denotes ,
T6087 9895-9900 JJ denotes AP-2γ
T6086 9892-9894 IN denotes as
T6085 9887-9891 JJ denotes such
T6084 9885-9886 -RRB- denotes )
T6083 9884-9885 PRP denotes s
T6082 9883-9884 -LRB- denotes (
T6081 9878-9883 NN denotes motif
T6080 9873-9877 NNP denotes PPxY
T6079 9871-9872 DT denotes a
T6078 9860-9870 VBG denotes possessing
T6077 9851-9859 NNS denotes proteins
T6076 9846-9850 IN denotes with
T6075 9837-9845 VB denotes interact
T6074 9833-9836 MD denotes may
T6073 9828-9832 NNP denotes WWOX
T6072 9825-9827 IN denotes of
T6071 9818-9824 NN denotes domain
T6070 9815-9817 NNP denotes WW
T6069 9809-9814 JJ denotes first
T6068 9805-9808 DT denotes The
T6067 9803-9804 . denotes .
T6066 9802-9803 -RRB- denotes )
T6065 9798-9802 CD denotes 2009
T6064 9796-9797 , denotes ,
T6063 9793-9796 FW denotes al.
T6062 9790-9792 FW denotes et
T6061 9785-9789 NNP denotes Hong
T6060 9784-9785 -LRB- denotes (
T6059 9777-9783 NN denotes cancer
T6058 9768-9776 NN denotes prostate
T6057 9764-9767 CC denotes and
T6056 9762-9763 , denotes ,
T6055 9761-9762 -RRB- denotes )
T6054 9757-9761 CD denotes 2008
T6053 9755-9756 , denotes ,
T6052 9752-9755 FW denotes al.
T6051 9749-9751 FW denotes et
T6050 9740-9748 NNP denotes Nakayama
T6049 9739-9740 -LRB- denotes (
T6048 9732-9738 NN denotes cancer
T6047 9721-9731 JJ denotes pancreatic
T6046 9719-9720 , denotes ,
T6045 9718-9719 -RRB- denotes )
T6044 9714-9718 CD denotes 2005
T6043 9712-9713 , denotes ,
T6042 9709-9712 FW denotes al.
T6041 9706-9708 FW denotes et
T6040 9699-9705 NNP denotes Fabbri
T6039 9698-9699 -LRB- denotes (
T6038 9691-9697 NN denotes cancer
T6037 9686-9690 NN denotes lung
T6036 9683-9685 IN denotes of
T6035 9676-9682 NN denotes growth
T6034 9672-9675 DT denotes the
T6033 9663-9671 VBZ denotes prevents
T6032 9658-9662 NN denotes gene
T6031 9653-9657 NNP denotes WWOX
T6030 9650-9652 IN denotes of
T6029 9638-9649 NNP denotes Restoration
T6028 9636-9637 . denotes .
T6027 9635-9636 -RRB- denotes )
T6026 9631-9635 CD denotes 2011
T6025 9629-9630 , denotes ,
T6024 9626-9629 FW denotes al.
T6023 9623-9625 FW denotes et
T6022 9617-9622 NNP denotes Kosla
T6021 9616-9617 -LRB- denotes (
T6020 9605-9615 NNS denotes multiforme
T6019 9592-9604 NN denotes glioblastoma
T6018 9588-9591 CC denotes and
T6017 9586-9587 , denotes ,
T6016 9585-9586 -RRB- denotes )
T6015 9581-9585 CD denotes 2007
T6014 9579-9580 , denotes ,
T6013 9576-9579 FW denotes al.
T6012 9573-9575 FW denotes et
T6011 9565-9572 NNP denotes Aqeilan
T6010 9563-9564 : denotes ;
T6009 9559-9563 CD denotes 2004
T6008 9557-9558 , denotes ,
T6007 9554-9557 FW denotes al.
T6006 9551-9553 FW denotes et
T6005 9545-9550 NNP denotes Guler
T6004 9544-9545 -LRB- denotes (
T6003 9534-9543 NN denotes carcinoma
T6002 9527-9533 NN denotes breast
T6001 9525-9526 , denotes ,
T6000 9524-9525 -RRB- denotes )
T5999 9520-9524 CD denotes 2004
T5998 9518-9519 , denotes ,
T5997 9515-9518 FW denotes al.
T5996 9512-9514 FW denotes et
T5995 9505-9511 NNP denotes Kuroki
T5994 9504-9505 -LRB- denotes (
T5993 9494-9503 NN denotes carcinoma
T5992 9483-9493 JJ denotes pancreatic
T5991 9481-9482 , denotes ,
T5990 9480-9481 -RRB- denotes )
T5989 9476-9480 CD denotes 2004
T5988 9474-9475 , denotes ,
T5892 7277-7280 FW denotes al.
T5891 7274-7276 FW denotes et
T5890 7268-7273 NNP denotes Salah
T5889 7266-7267 : denotes ;
T5888 7262-7266 CD denotes 2007
T5887 7260-7261 , denotes ,
T5886 7257-7260 FW denotes al.
T5885 7254-7256 FW denotes et
T5884 7249-7253 NNP denotes Hong
T5883 7247-7248 : denotes ;
T5882 7243-7247 CD denotes 2007
T5881 7241-7242 , denotes ,
T5880 7237-7241 CD denotes 2004
T5879 7235-7236 , denotes ,
T5878 7232-7235 FW denotes al.
T5877 7229-7231 FW denotes et
T5876 7221-7228 NNP denotes Aqeilan
T5875 7219-7220 : denotes ;
T5874 7215-7219 CD denotes 2010
T5873 7213-7214 , denotes ,
T5872 7209-7213 CD denotes 2007
T5871 7207-7208 , denotes ,
T5870 7203-7207 CD denotes 2001
T5869 7201-7202 , denotes ,
T5868 7198-7201 FW denotes al.
T5867 7195-7197 FW denotes et
T5866 7189-7194 NNP denotes Chang
T5865 7188-7189 -LRB- denotes (
T5864 7185-7187 NN denotes D3
T5863 7180-7184 NN denotes tail
T5862 7169-7179 JJ denotes C-terminal
T5861 7156-7168 JJ denotes proapoptotic
T5860 7154-7155 DT denotes a
T5859 7150-7153 CC denotes and
T5858 7148-7149 , denotes ,
T5857 7142-7148 NN denotes domain
T5856 7140-7141 -RRB- denotes )
T5855 7137-7140 NNP denotes SDR
T5854 7136-7137 -LRB- denotes (
T5853 7112-7135 NN denotes dehydrogenase/reductase
T5852 7104-7111 NN denotes alcohol
T5851 7092-7103 NN denotes short-chain
T5850 7081-7091 JJ denotes C-terminal
T5849 7079-7080 DT denotes a
T5848 7077-7078 , denotes ,
T5847 7070-7077 NNS denotes domains
T5846 7067-7069 NNP denotes WW
T5845 7056-7066 JJ denotes N-terminal
T5844 7052-7055 CD denotes two
T5843 7049-7051 IN denotes of
T5842 7040-7048 VBN denotes composed
T5841 7037-7039 VBZ denotes is
T5840 7029-7036 NN denotes protein
T5839 7024-7028 NNP denotes WWOX
T6210 10500-10504 NNP denotes WWOX
T6209 10498-10499 , denotes ,
T6208 10488-10498 NNS denotes conditions
T6207 10481-10487 NN denotes stress
T6206 10475-10480 IN denotes Under
T6205 10473-10474 . denotes .
T6204 10465-10473 VBN denotes observed
T5838 7012-7023 JJ denotes full-length
T5837 7008-7011 DT denotes The
T5836 7006-7007 . denotes .
T5835 7000-7006 CD denotes FRA16D
T5834 6995-6999 NN denotes site
T5833 6987-6994 JJ denotes fragile
T5832 6980-6986 JJ denotes common
T5831 6976-6979 DT denotes the
T5830 6973-6975 IN denotes as
T5829 6967-6972 VBN denotes known
T5828 6962-6966 NN denotes area
T5827 6959-6961 DT denotes an
T5826 6957-6958 , denotes ,
T5825 6953-6957 CD denotes 24.1
T5824 6950-6952 CD denotes .3
T5823 6945-6950 CD denotes 16q23
T5822 6934-6944 NN denotes chromosome
T5821 6931-6933 IN denotes in
T5820 6923-6930 VBN denotes located
T5819 6920-6922 VBZ denotes is
T5818 6915-6919 NN denotes gene
T5817 6910-6914 DT denotes This
T5816 6908-6909 . denotes .
T5815 6904-6908 NN denotes gene
T5814 6894-6903 NNP denotes WWOX/Wwox
T5813 6888-6893 NN denotes mouse
T5812 6885-6887 CC denotes or
T5811 6879-6884 JJ denotes human
T5810 6876-6878 IN denotes by
T5809 6868-6875 VBN denotes encoded
T5808 6865-6867 VBZ denotes is
T5807 6863-6864 , denotes ,
T5806 6859-6863 NNP denotes WOX1
T5805 6856-6858 CC denotes or
T5804 6854-6855 , denotes ,
T5803 6851-6854 IN denotes FOR
T5802 6849-6850 , denotes ,
T5801 6845-6849 NNP denotes WWOX
T5800 6842-6844 IN denotes as
T5799 6836-6841 VBN denotes known
T5798 6834-6835 , denotes ,
T5797 6820-6834 NN denotes oxidoreductase
T5796 6802-6819 JJ denotes domain-containing
T5795 6799-6801 NNP denotes WW
T5794 6797-6798 . denotes .
T5793 6796-6797 -RRB- denotes )
T5792 6792-6796 CD denotes 2012
T5791 6790-6791 , denotes ,
T5790 6787-6790 FW denotes al.
T5789 6784-6786 FW denotes et
T5788 6777-6783 NNP denotes Chiang
T5787 6776-6777 -LRB- denotes (
T5786 6770-6775 NNS denotes cells
T5785 6757-6769 NN denotes glioblastoma
T5784 6754-6756 IN denotes of
T5783 6744-6753 NN denotes apoptosis
T5782 6740-6743 DT denotes the
T5781 6731-6739 VB denotes regulate
T5780 6728-6730 TO denotes to
T5779 6722-6727 VBN denotes shown
T5778 6717-6721 VBD denotes were
T5777 6712-6716 NNP denotes WWOX
T5776 6708-6711 CC denotes and
T5775 6704-6707 NN denotes p53
T5774 6692-6703 NNS denotes suppressors
T5773 6686-6691 NN denotes tumor
T5772 6684-6685 , denotes ,
T5987 9471-9474 FW denotes al.
T5986 9468-9470 FW denotes et
T5985 9460-9467 JJ denotes Aqeilan
T5984 9459-9460 -LRB- denotes (
T5983 9449-9458 NN denotes carcinoma
T5982 9441-9448 JJ denotes gastric
T5981 9439-9440 , denotes ,
T5980 9438-9439 -RRB- denotes )
T5979 9434-9438 CD denotes 2004
T5978 9432-9433 , denotes ,
T5977 9424-9432 NNP denotes Furukawa
T5976 9420-9423 CC denotes and
T5975 9414-9419 NNP denotes Ishii
T5974 9413-9414 -LRB- denotes (
T5973 9400-9412 NNS denotes malignancies
T5972 9386-9399 JJ denotes hematopoietic
T5971 9384-9385 , denotes ,
T5970 9383-9384 -RRB- denotes )
T5969 9379-9383 CD denotes 2007
T5968 9377-9378 , denotes ,
T5967 9374-9377 FW denotes al.
T5966 9371-9373 FW denotes et
T5965 9364-9370 NNP denotes Donati
T5964 9363-9364 -LRB- denotes (
T5963 9353-9362 NN denotes carcinoma
T5962 9348-9352 NN denotes lung
T5961 9343-9347 NN denotes cell
T5960 9333-9342 JJ denotes non-small
T5959 9330-9332 IN denotes as
T5958 9325-9329 JJ denotes such
T5957 9323-9324 , denotes ,
T5956 9316-9323 NNS denotes cancers
T5955 9306-9315 JJ denotes malignant
T5954 9297-9305 JJ denotes multiple
T5953 9294-9296 IN denotes in
T5952 9281-9293 NN denotes modification
T5951 9270-9280 JJ denotes epigenetic
T5950 9265-9269 IN denotes from
T5949 9260-9264 VBN denotes lost
T5948 9257-9259 CC denotes or
T5947 9249-9256 VBN denotes altered
T5946 9242-9248 RB denotes either
T5945 9239-9241 VBZ denotes is
T5944 9234-9238 NNP denotes WWOX
T5943 9231-9233 IN denotes of
T5942 9220-9230 NN denotes Expression
T5941 7499-7500 . denotes .
T5940 7498-7499 -RRB- denotes )
T5939 7494-7498 CD denotes 2012
T5938 7492-7493 , denotes ,
T5937 7489-7492 FW denotes al.
T5936 7486-7488 FW denotes et
T5935 7483-7485 NNP denotes Su
T5934 7481-7482 : denotes ;
T5933 7476-7481 JJ denotes 2005a
T5932 7474-7475 , denotes ,
T5931 7471-7474 FW denotes al.
T5930 7468-7470 FW denotes et
T5929 7462-7467 NNP denotes Chang
T5928 7461-7462 -LRB- denotes (
T5927 7452-7460 NN denotes estrogen
T5926 7448-7451 CC denotes and
T5925 7439-7447 NN denotes androgen
T5924 7434-7438 IN denotes with
T5923 7422-7433 VBG denotes interacting
T5922 7419-7421 IN denotes of
T5921 7411-7418 JJ denotes capable
T5920 7405-7410 NN denotes motif
T5919 7400-7404 NNP denotes NSYK
T5918 7397-7399 DT denotes an
T5917 7387-7396 VBZ denotes possesses
T5916 7380-7386 NN denotes domain
T5915 7376-7379 NNP denotes SDR
T5914 7372-7375 PRP$ denotes its
T5913 7366-7371 IN denotes since
T5912 7364-7365 , denotes ,
T5911 7356-7364 NNS denotes hormones
T5910 7348-7355 JJ denotes steroid
T5909 7344-7347 NN denotes sex
T5908 7340-7343 IN denotes for
T5907 7331-7339 NN denotes receptor
T5906 7319-7330 NN denotes alternative
T5905 7316-7318 DT denotes an
T5904 7313-7315 IN denotes as
T5903 7309-7312 VB denotes act
T5902 7305-7308 MD denotes may
T5901 7300-7304 NNP denotes WWOX
T5900 7298-7299 . denotes .
T5899 7297-7298 -RRB- denotes )
T5898 7296-7297 CD denotes 1
T5897 7289-7295 NN denotes Figure
T5896 7288-7289 -LRB- denotes (
T5895 7286-7287 -RRB- denotes )
T5894 7282-7286 CD denotes 2012
T5893 7280-7281 , denotes ,
T3530 6632-6633 . denotes .
T3529 6621-6632 VBN denotes established
T3528 6618-6620 VB denotes be
T3527 6615-6617 TO denotes to
T3526 6611-6614 RB denotes yet
T3525 6607-6610 VBZ denotes has
T3524 6598-6606 NN denotes function
T3523 6587-6597 JJ denotes biological
T3522 6583-6586 PRP$ denotes its
T3521 6580-6582 TO denotes to
T3520 6571-6579 JJ denotes relative
T3519 6565-6570 NNS denotes cells
T3518 6560-6564 NN denotes stem
T3517 6553-6559 NN denotes cancer
T3516 6546-6552 NN denotes glioma
T3515 6542-6545 IN denotes for
T3514 6535-6541 NN denotes marker
T3513 6533-6534 DT denotes a
T3512 6530-6532 IN denotes as
T3511 6524-6529 NNP denotes CD133
T3510 6521-6523 IN denotes of
T3509 6516-6520 NN denotes role
T3508 6512-6515 DT denotes the
T3507 6510-6511 , denotes ,
T3506 6503-6510 RB denotes However
T3505 6501-6502 . denotes .
T3504 6500-6501 -RRB- denotes )
T3503 6496-6500 CD denotes 2012
T3502 6494-6495 , denotes ,
T3501 6484-6494 NNP denotes Pilkington
T3500 6480-6483 CC denotes and
T3499 6472-6479 NNP denotes Donovan
T3498 6471-6472 -LRB- denotes (
T3497 6465-6470 NNS denotes cells
T3496 6460-6464 NN denotes stem
T3495 6453-6459 NN denotes cancer
T3494 6449-6452 CC denotes and
T3493 6443-6448 NNS denotes cells
T3492 6438-6442 NN denotes stem
T3491 6431-6437 JJ denotes normal
T3490 6426-6430 DT denotes both
T3489 6423-6425 IN denotes in
T3488 6413-6422 VBN denotes expressed
T3487 6409-6412 VBP denotes are
T3486 6403-6408 NNS denotes cells
T3485 6398-6402 NN denotes stem
T3484 6391-6397 NN denotes cancer
T3483 6376-6390 JJ denotes CD133-positive
T3482 6374-6375 . denotes .
T3481 6373-6374 -RRB- denotes )
T3480 6369-6373 CD denotes 2012
T3479 6367-6368 , denotes ,
T3478 6364-6367 FW denotes al.
T3477 6361-6363 FW denotes et
T3476 6356-6360 NNP denotes Chen
T3475 6354-6355 : denotes ;
T3474 6350-6354 CD denotes 2011
T3473 6348-6349 , denotes ,
T3472 6345-6348 FW denotes al.
T3471 6342-6344 FW denotes et
T3470 6336-6341 NNP denotes Beier
T3469 6335-6336 -LRB- denotes (
T3468 6327-6334 VBN denotes thought
T3467 6316-6326 RB denotes previously
T3466 6311-6315 IN denotes than
T3465 6299-6310 JJ denotes complicated
T3464 6294-6298 RBR denotes more
T3463 6289-6293 VBN denotes been
T3462 6285-6288 VBZ denotes has
T3461 6279-6284 NNS denotes drugs
T3460 6262-6278 JJ denotes chemotherapeutic
T3459 6256-6261 JJ denotes other
T3458 6252-6255 CC denotes and
T3457 6248-6251 NNP denotes TMZ
T3456 6243-6247 IN denotes with
T3455 6233-6242 NN denotes treatment
T3454 6228-6232 IN denotes from
T3453 6219-6227 NN denotes survival
T3452 6214-6218 NN denotes cell
T3451 6209-6213 NN denotes stem
T3450 6202-6208 NN denotes cancer
T3449 6199-6201 IN denotes of
T3448 6191-6198 NN denotes concept
T3447 6187-6190 DT denotes The
T3446 6185-6186 . denotes .
T3445 6176-6185 NN denotes treatment
T3444 6172-6175 NNP denotes TMZ
T3443 6169-6171 IN denotes in
T3442 6161-6168 NN denotes failure
T3441 6158-6160 TO denotes to
T3440 6154-6157 NN denotes key
T3439 6150-6153 DT denotes the
T3438 6141-6149 RB denotes probably
T3437 6137-6140 VBP denotes are
T3436 6131-6136 NNS denotes cells
T3435 6126-6130 NN denotes stem
T3434 6119-6125 NNP denotes Cancer
T3433 6117-6118 . denotes .
T3432 6116-6117 -RRB- denotes )
T3431 6112-6116 CD denotes 2012
T3430 6110-6111 , denotes ,
T3429 6107-6110 FW denotes al.
T3428 6104-6106 FW denotes et
T3427 6100-6103 NNP denotes Sun
T3426 6099-6100 -LRB- denotes (
T3425 6094-6098 NNS denotes GBMs
T3424 6091-6093 IN denotes in
T3423 6080-6090 NN denotes resistance
T3422 6076-6079 NNP denotes TMZ
T3421 6068-6075 VB denotes reverse
T3420 6065-6067 TO denotes to
T3419 6056-6064 VBN denotes utilized
T3418 6053-6055 VB denotes be
T3417 6049-6052 MD denotes can
T3416 6039-6048 NN denotes hyperoxia
T3415 6031-6038 VBN denotes Induced
T3414 6029-6030 . denotes .
T3413 6019-6029 NN denotes resistance
T3412 6015-6018 NNP denotes TMZ
T3411 6012-6014 IN denotes of
T3410 6000-6011 NN denotes development
T3409 5996-5999 DT denotes the
T3408 5991-5995 IN denotes with
T3407 5980-5990 VBN denotes associated
T3406 5977-5979 VB denotes be
T3405 5973-5976 MD denotes may
T3404 5969-5972 CC denotes and
T3403 5964-5968 NNS denotes GBMs
T3402 5961-5963 IN denotes in
T3401 5954-5960 JJ denotes common
T3400 5951-5953 VBZ denotes is
T3399 5943-5950 NN denotes hypoxia
T3398 5930-5942 NNP denotes Intratumoral
T3397 5928-5929 . denotes .
T3396 5927-5928 -RRB- denotes )
T3395 5923-5927 CD denotes 2012
T3394 5921-5922 , denotes ,
T3393 5918-5921 FW denotes al.
T3392 5915-5917 FW denotes et
T3391 5907-5914 NNP denotes Kohsaka
T3390 5906-5907 -LRB- denotes (
T3389 5900-5905 NNS denotes lines
T3388 5895-5899 NN denotes cell
T3387 5891-5894 NNP denotes GBM
T3386 5881-5890 JJ denotes resistant
T3385 5878-5880 IN denotes in
T3384 5869-5877 NN denotes efficacy
T3383 5865-5868 NNP denotes TMZ
T3382 5853-5864 NNS denotes potentiates
T3381 5843-5852 JJ denotes knockdown
T3380 5837-5842 CD denotes STAT3
T3379 5834-5836 CC denotes or
T3378 5824-5833 NN denotes inhibitor
T3377 5818-5823 CD denotes STAT3
T3376 5816-5817 . denotes .
T3375 5815-5816 -RRB- denotes )
T3374 5811-5815 CD denotes 2012
T3373 5809-5810 , denotes ,
T3372 5806-5809 FW denotes al.
T3371 5803-5805 FW denotes et
T3370 5797-5802 NNP denotes Huang
T3369 5796-5797 -LRB- denotes (
T3368 5786-5795 NN denotes mechanism
T3367 5770-5785 JJ denotes NF-κB-dependent
T3366 5767-5769 DT denotes an
T3365 5763-5766 IN denotes via
T3364 5752-5762 NN denotes resistance
T3363 5748-5751 NNP denotes TMZ
T3362 5739-5747 VBZ denotes reverses
T3361 5737-5738 , denotes ,
T3332 5579-5587 JJ denotes valproic
T3331 5575-5578 CC denotes and
T3330 5573-5574 , denotes ,
T3329 5562-5573 NN denotes resveratrol
T3328 5560-5561 , denotes ,
T3327 5559-5560 -RRB- denotes )
T3326 5556-5559 NNP denotes LEV
T3325 5555-5556 -LRB- denotes (
T3324 5541-5554 NN denotes levetiracetam
T3323 5539-5540 , denotes ,
T3322 5538-5539 -RRB- denotes )
T3321 5533-5538 NNP denotes IFN-β
T3320 5532-5533 -LRB- denotes (
T3319 5519-5531 NNP denotes Interferon-β
T3318 5517-5518 . denotes .
T3317 5516-5517 -RRB- denotes )
T3316 5512-5516 CD denotes 2011
T3315 5510-5511 , denotes ,
T3314 5507-5510 FW denotes al.
T3313 5504-5506 FW denotes et
T3312 5495-5503 NNP denotes Goellner
T3311 5494-5495 -LRB- denotes (
T3310 5490-5493 NNP denotes GBM
T3309 5480-5489 JJ denotes recurrent
T3308 5476-5479 CC denotes and
T3307 5466-5475 JJ denotes resistant
T3306 5461-5465 IN denotes with
T3305 5452-5460 NNS denotes patients
T3304 5449-5451 IN denotes in
T3303 5438-5448 NN denotes resistance
T3302 5434-5437 NNP denotes TMZ
T3301 5426-5433 VB denotes reverse
T3300 5422-5425 MD denotes may
T3299 5409-5421 NN denotes biosynthesis
T3298 5407-5408 -RRB- denotes )
T3297 5406-5407 VBN denotes +
T3296 5405-5406 -LRB- denotes (
T3295 5402-5405 NNP denotes NAD
T3294 5398-5401 CC denotes and
T3293 5391-5397 NN denotes repair
T3292 5382-5390 NN denotes excision
T3291 5377-5381 NN denotes base
T3290 5374-5376 IN denotes of
T3289 5364-5373 VBG denotes targeting
T3288 5359-5363 JJ denotes Dual
T3287 5357-5358 . denotes .
T3286 5356-5357 -RRB- denotes )
T3285 5351-5356 JJ denotes 2012b
T3284 5349-5350 , denotes ,
T3283 5346-5349 FW denotes al.
T3282 5343-5345 FW denotes et
T3281 5337-5342 NNP denotes Zhang
T3280 5335-5336 : denotes ;
T3279 5331-5335 CD denotes 2011
T3278 5329-5330 , denotes ,
T3277 5326-5329 FW denotes al.
T3276 5323-5325 FW denotes et
T3275 5314-5322 NNP denotes Goellner
T3274 5313-5314 -LRB- denotes (
T3273 5303-5312 VBN denotes tolerated
T3272 5300-5302 CC denotes or
T3271 5291-5299 VBN denotes repaired
T3270 5287-5290 VBP denotes are
T3269 5279-5286 NNS denotes adducts
T3268 5262-5278 JJ denotes O6-methylguanine
T3267 5257-5261 WRB denotes when
T3266 5244-5256 RB denotes particularly
T3265 5231-5243 NN denotes cytotoxicity
T3264 5227-5230 NNP denotes TMZ
T3263 5224-5226 TO denotes to
T3262 5210-5223 RB denotes significantly
T3261 5198-5209 VBZ denotes contributes
T3260 5191-5197 NN denotes repair
T3259 5182-5190 NN denotes excision
T3258 5177-5181 NN denotes base
T3257 5174-5176 IN denotes of
T3256 5153-5173 NN denotes Methoxyamine-blocker
T3255 5151-5152 . denotes .
T3254 5150-5151 -RRB- denotes )
T3253 5145-5150 JJ denotes 2012b
T3252 5143-5144 , denotes ,
T3251 5140-5143 FW denotes al.
T3250 5137-5139 FW denotes et
T3249 5131-5136 NNP denotes Zhang
T3248 5130-5131 -LRB- denotes (
T3247 5126-5129 NNP denotes TMZ
T3246 5123-5125 TO denotes to
T3245 5116-5122 NNS denotes tumors
T3244 5106-5115 VB denotes sensitize
T3243 5103-5105 TO denotes to
T3242 5091-5102 NN denotes lomeguatrib
T3241 5087-5090 CC denotes and
T3240 5070-5086 NN denotes O6-benzylguanine
T3239 5068-5069 , denotes ,
T3238 5052-5068 NNS denotes pseudosubstrates
T3237 5047-5051 NNP denotes MGMT
T3236 5044-5046 IN denotes by
T3235 5035-5043 VBN denotes achieved
T3234 5032-5034 VB denotes be
T3233 5028-5031 MD denotes may
T3232 5017-5027 NN denotes resistance
T3231 5013-5016 NNP denotes TMZ
T3230 5010-5012 IN denotes of
T3229 5001-5009 NN denotes Reversal
T3228 4999-5000 . denotes .
T3227 4998-4999 -RRB- denotes )
T3226 4994-4998 CD denotes 2011
T3225 4992-4993 , denotes ,
T3224 4989-4992 FW denotes al.
T3223 4986-4988 FW denotes et
T3222 4980-4985 NNP denotes Oliva
T3221 4979-4980 -LRB- denotes (
T3220 4971-4978 NNS denotes gliomas
T3219 4968-4970 IN denotes in
T3218 4957-4967 NN denotes resistance
T3217 4953-4956 NNP denotes TMZ
T3216 4950-4952 TO denotes to
T3215 4945-4949 NN denotes part
T3214 4942-4944 IN denotes in
T3213 4930-4941 VBZ denotes contributes
T3212 4922-4929 NN denotes oxidase
T3211 4920-4921 NN denotes c
T3210 4909-4919 NN denotes cytochrome
T3209 4906-4908 IN denotes by
T3208 4896-4905 VBN denotes regulated
T3207 4894-4895 -RRB- denotes )
T3206 4891-4894 NNP denotes ROS
T3205 4890-4891 -LRB- denotes (
T3204 4882-4889 NNS denotes species
T3203 4875-4881 NN denotes oxygen
T3202 4866-4874 JJ denotes reactive
T3201 4863-4865 IN denotes of
T3200 4852-4862 NN denotes production
T3199 4848-4851 DT denotes the
T3198 4839-4847 VB denotes suppress
T3197 4836-4838 TO denotes to
T3196 4827-4835 NN denotes coupling
T3195 4821-4826 NN denotes chain
T3194 4809-4820 JJ denotes respiratory
T3193 4795-4808 JJ denotes mitochondrial
T3192 4792-4794 IN denotes of
T3191 4779-4791 NNP denotes Upregulation
T3190 4777-4778 . denotes .
T3189 4776-4777 -RRB- denotes )
T3188 4772-4776 CD denotes 2012
T3187 4770-4771 , denotes ,
T3186 4767-4770 FW denotes al.
T3185 4764-4766 FW denotes et
T3184 4754-4763 NNP denotes Agnihotri
T3183 4753-4754 -LRB- denotes (
T3182 4742-4752 NN denotes resistance
T3181 4738-4741 NNP denotes TMZ
T3180 4734-4737 DT denotes the
T3179 4731-4733 IN denotes in
T3178 4718-4730 VBZ denotes participates
T3177 4713-4717 RB denotes also
T3176 4711-4712 , denotes ,
T3175 4695-4711 JJ denotes N7-methylguanine
T3174 4691-4694 CC denotes and
T3173 4674-4690 JJ denotes N3-methyladenine
T3172 4666-4673 NNS denotes lesions
T3171 4656-4665 JJ denotes cytotoxic
T3170 4652-4655 DT denotes the
T3169 4644-4651 NNS denotes repairs
T3168 4638-4643 WDT denotes which
T3167 4636-4637 , denotes ,
T3166 4635-4636 -RRB- denotes )
T3165 4631-4635 NNP denotes APNG
T3164 4630-4631 -LRB- denotes (
T3163 4600-4629 JJ denotes alkylpurine-DNA-N-glycosylase
T3162 4593-4599 NN denotes enzyme
T3161 4586-4592 NN denotes repair
T3160 4577-4585 NN denotes excision
T3159 4572-4576 NN denotes base
T3158 4568-4571 DT denotes The
T3157 4566-4567 . denotes .
T3156 4560-4566 NNS denotes tumors
T3155 4554-4559 NN denotes brain
T3154 4543-4553 JJ denotes high-grade
T3153 4539-4542 IN denotes for
T3152 4532-4538 NN denotes target
T3151 4520-4531 JJ denotes therapeutic
T3150 4518-4519 DT denotes a
T3149 4515-4517 IN denotes as
T3148 4504-4514 VBN denotes considered
T3147 4501-4503 VBZ denotes is
T3146 4492-4500 NN denotes integrin
T3145 4487-4491 JJ denotes α5β1
T3144 4485-4486 . denotes .
T3143 4484-4485 -RRB- denotes )
T3142 4480-4484 CD denotes 2012
T3141 4478-4479 , denotes ,
T3140 4475-4478 FW denotes al.
T3139 4472-4474 FW denotes et
T3138 4461-4471 NNP denotes Janouskova
T3137 4460-4461 -LRB- denotes (
T3136 4456-4459 NNP denotes TMZ
T3135 4453-4455 TO denotes to
T3134 4442-4452 NN denotes resistance
T3133 4437-4441 NN denotes cell
T3132 4430-4436 NN denotes glioma
T3131 4422-4429 VBZ denotes induces
T3130 4416-4421 NN denotes event
T3129 4412-4415 DT denotes the
T3128 4408-4411 CC denotes and
T3127 4406-4407 , denotes ,
T3126 4397-4406 VBG denotes signaling
T3125 4393-4396 NN denotes p53
T3124 4383-4392 VBZ denotes regulates
T3123 4372-4382 RB denotes negatively
T3122 4363-4371 NN denotes integrin
T3121 4358-4362 JJ denotes α5β1
T3120 4356-4357 . denotes .
T3119 4344-4356 JJ denotes chemotherapy
T3118 4340-4343 CC denotes and
T3117 4327-4339 JJ denotes radiotherapy
T3111 4289-4292 DT denotes the
T3110 4286-4288 IN denotes in
T3109 4281-4285 NN denotes role
T3108 4279-4280 DT denotes a
T3107 4274-4278 VBP denotes play
T3106 4264-4273 NNS denotes Integrins
T3105 4262-4263 . denotes .
T3104 4261-4262 -RRB- denotes )
T3103 4257-4261 CD denotes 2012
T3102 4255-4256 , denotes ,
T3101 4252-4255 FW denotes al.
T3100 4249-4251 FW denotes et
T3099 4246-4248 NNP denotes Li
T3098 4245-4246 -LRB- denotes (
T3097 4239-4244 NNS denotes cells
T3096 4232-4238 NN denotes cancer
T3095 4228-4231 IN denotes for
T3094 4221-4227 NN denotes factor
T3093 4208-4220 JJ denotes pro-survival
T3092 4206-4207 DT denotes a
T3091 4203-4205 IN denotes as
T3090 4192-4202 VBN denotes considered
T3089 4189-4191 VBZ denotes is
T3088 4177-4188 NN denotes MicroRNA-21
T3087 4175-4176 . denotes .
T3086 4174-4175 -RRB- denotes )
T3085 4170-4174 CD denotes 2010
T3084 4168-4169 , denotes ,
T3083 4165-4168 FW denotes al.
T3082 4162-4164 FW denotes et
T3081 4158-4161 NNP denotes Shi
T3080 4157-4158 -LRB- denotes (
T3079 4147-4156 NN denotes apoptosis
T3078 4135-4146 JJ denotes TMZ-induced
T3077 4126-4134 VBG denotes blocking
T3076 4118-4125 RB denotes thereby
T3075 4116-4117 , denotes ,
T3074 4108-4116 NN denotes activity
T3073 4098-4107 JJ denotes caspase-3
T3072 4094-4097 CC denotes and
T3071 4088-4093 NN denotes ratio
T3070 4085-4087 CD denotes -2
T3069 4078-4085 NNP denotes Bax/Bcl
T3068 4070-4077 VBZ denotes reduces
T3067 4058-4069 NN denotes microRNA-21
T3066 4044-4057 VBD denotes overexpressed
T3065 4042-4043 , denotes ,
T3064 4030-4042 RB denotes Intriguingly
T3063 4028-4029 . denotes .
T3062 4020-4028 NN denotes survival
T3061 4012-4019 NN denotes patient
T3060 4005-4011 NN denotes cancer
T3059 3996-4004 VBZ denotes prolongs
T3058 3994-3995 , denotes ,
T3360 5727-5737 NN denotes polyphenol
T3359 5719-5726 JJ denotes natural
T3358 5717-5718 DT denotes a
T3357 5715-5716 , denotes ,
T3356 5704-5715 NNP denotes Resveratrol
T3355 5702-5703 . denotes .
T3354 5701-5702 -RRB- denotes )
T3353 5697-5701 CD denotes 2012
T3352 5695-5696 , denotes ,
T3351 5692-5695 FW denotes al.
T3350 5689-5691 FW denotes et
T3349 5682-5688 NNP denotes Nakada
T3348 5681-5682 -LRB- denotes (
T3347 5670-5680 NNS denotes mechanisms
T3346 5658-5669 JJ denotes independent
T3345 5657-5658 : denotes -
T3344 5654-5656 CC denotes or
T3343 5639-5653 NNP denotes MGMT-dependent
T3342 5631-5638 IN denotes through
T3341 5627-5630 NNP denotes TMZ
T3340 5624-5626 IN denotes of
T3339 5612-5623 NN denotes sensitivity
T3338 5608-5611 DT denotes the
T3337 5599-5607 VB denotes increase
T3336 5597-5598 -RRB- denotes )
T3335 5594-5597 NNP denotes VAP
T3334 5593-5594 -LRB- denotes (
T3333 5588-5592 NN denotes acid
T3057 3984-3994 NN denotes expression
T3056 3976-3983 NN denotes protein
T3055 3971-3975 NNP denotes MGMT
T3054 3964-3970 VBZ denotes blocks
T3053 3958-3963 WDT denotes which
T3052 3956-3957 , denotes ,
T3051 3945-3956 NN denotes methylation
T3050 3936-3944 NN denotes promoter
T3049 3931-3935 NN denotes gene
T3048 3926-3930 NNP denotes MGMT
T3047 3923-3925 IN denotes in
T3046 3914-3922 NN denotes increase
T3045 3911-3913 DT denotes An
T3044 3909-3910 . denotes .
T3043 3908-3909 -RRB- denotes )
T3042 3904-3908 CD denotes 2012
T3041 3902-3903 , denotes ,
T3040 3899-3902 FW denotes al.
T3039 3896-3898 FW denotes et
T3038 3887-3895 NNP denotes Villalva
T3037 3886-3887 -LRB- denotes (
T3036 3870-3885 NN denotes differentiation
T3035 3867-3869 TO denotes to
T3034 3857-3866 VBN denotes committed
T3033 3851-3856 NNS denotes cells
T3032 3848-3850 IN denotes in
T3031 3839-3847 NN denotes promoter
T3030 3834-3838 NN denotes gene
T3029 3829-3833 NNP denotes MGMT
T3028 3826-3828 IN denotes of
T3027 3819-3825 NN denotes status
T3026 3807-3818 NN denotes methylation
T3025 3803-3806 DT denotes the
T3024 3798-3802 IN denotes with
T3023 3787-3797 VBN denotes associated
T3022 3773-3786 RB denotes significantly
T3021 3770-3772 VBZ denotes is
T3020 3766-3769 NNP denotes TMZ
T3019 3763-3765 TO denotes to
T3018 3751-3762 NN denotes Sensitivity
T3017 3749-3750 . denotes .
T3016 3743-3749 NN denotes system
T3015 3739-3742 NNP denotes MMR
T3014 3735-3738 DT denotes the
T3013 3732-3734 IN denotes of
T3012 3724-3731 NN denotes absence
T3011 3720-3723 DT denotes the
T3010 3717-3719 IN denotes in
T3009 3711-3716 VBZ denotes fails
T3008 3701-3710 VBG denotes signaling
T3007 3691-3700 JJ denotes apoptotic
T3006 3688-3690 IN denotes of
T3005 3677-3687 NN denotes initiation
T3004 3673-3676 DT denotes The
T3003 3671-3672 . denotes .
T3002 3670-3671 -RRB- denotes )
T3001 3666-3670 CD denotes 2008
T3000 3664-3665 , denotes ,
T2999 3661-3664 FW denotes al.
T2998 3658-3660 FW denotes et
T2997 3649-3657 NNP denotes Sarkaria
T2996 3647-3648 : denotes ;
T2995 3643-3647 CD denotes 2008
T2994 3641-3642 , denotes ,
T2993 3638-3641 FW denotes al.
T2992 3635-3637 FW denotes et
T2991 3630-3634 NNP denotes Hegi
T2990 3628-3629 : denotes ;
T2989 3624-3628 CD denotes 2006
T2988 3622-3623 , denotes ,
T2987 3619-3622 FW denotes al.
T2986 3616-3618 FW denotes et
T2985 3608-3615 NNP denotes Pollack
T2984 3607-3608 -LRB- denotes (
T2983 3601-3606 NNS denotes cases
T2982 3592-3600 JJ denotes clinical
T2981 3587-3591 JJ denotes many
T2980 3584-3586 IN denotes in
T2979 3573-3583 NN denotes resistance
T2978 3569-3572 NNP denotes TMZ
T2977 3566-3568 TO denotes to
T2976 3552-3565 RB denotes significantly
T2975 3540-3551 VBZ denotes contributes
T2974 3536-3539 NNP denotes MMR
T2973 3533-3535 IN denotes of
T2972 3528-3532 NN denotes loss
T2971 3525-3527 CC denotes or
T2970 3520-3524 NNP denotes MGMT
T2969 3517-3519 IN denotes of
T2968 3506-3516 NN denotes expression
T2967 3501-3505 NNP denotes High
T2966 3499-3500 . denotes .
T2965 3498-3499 -RRB- denotes )
T2964 3494-3498 CD denotes 2007
T2963 3492-3493 , denotes ,
T2962 3489-3492 FW denotes al.
T2961 3486-3488 FW denotes et
T2960 3481-3485 NNP denotes Roos
T2959 3479-3480 : denotes ;
T2958 3475-3479 CD denotes 2006
T2957 3473-3474 , denotes ,
T2956 3465-3473 NNP denotes Edelmann
T2955 3461-3464 CC denotes and
T2954 3456-3460 NNP denotes Wang
T2953 3454-3455 : denotes ;
T2952 3450-3454 CD denotes 2004
T2951 3448-3449 , denotes ,
T2950 3445-3448 FW denotes al.
T2949 3442-3444 FW denotes et
T2948 3433-3441 NNP denotes Caporali
T2947 3432-3433 -LRB- denotes (
T2946 3426-3431 NN denotes death
T2945 3421-3425 NN denotes cell
T2944 3411-3420 JJ denotes apoptotic
T2943 3408-3410 TO denotes to
T2942 3402-3407 VBZ denotes leads
T2941 3391-3401 RB denotes ultimately
T2940 3386-3390 WDT denotes that
T2939 3379-3385 NN denotes kinase
T2938 3371-3378 NN denotes protein
T2937 3358-3370 JJ denotes Rad3-related
T2936 3355-3357 CC denotes or
T2935 3346-3354 NNS denotes proteins
T2934 3344-3345 -RRB- denotes )
T2933 3341-3344 NNP denotes MMR
T2932 3340-3341 -LRB- denotes (
T2931 3323-3339 NN denotes repair-deficient
T2930 3314-3322 NN denotes mismatch
T2929 3311-3313 IN denotes of
T2928 3300-3310 NN denotes activation
T2927 3290-3299 NNS denotes initiates
T2926 3273-3289 JJ denotes O6-methylguanine
T2925 3271-3272 , denotes ,
T2924 3265-3271 NN denotes repair
T2923 3260-3264 NNP denotes MGMT
T2922 3252-3259 IN denotes Without
T2921 3250-3251 . denotes .
T2920 3249-3250 -RRB- denotes )
T2919 3244-3249 JJ denotes 2012b
T2918 3242-3243 , denotes ,
T2917 3239-3242 FW denotes al.
T2916 3236-3238 FW denotes et
T2915 3230-3235 NNP denotes Zhang
T2914 3228-3229 : denotes ;
T2913 3224-3228 CD denotes 2009
T2912 3222-3223 , denotes ,
T2911 3219-3222 FW denotes al.
T2910 3216-3218 FW denotes et
T2909 3206-3215 NNP denotes Fukushima
T2908 3204-3205 : denotes ;
T2907 3200-3204 CD denotes 2008
T2906 3198-3199 , denotes ,
T2905 3195-3198 FW denotes al.
T2904 3192-3194 FW denotes et
T2903 3187-3191 NNP denotes Hegi
T2902 3185-3186 : denotes ;
T2901 3181-3185 CD denotes 2006
T2900 3179-3180 , denotes ,
T2899 3176-3179 FW denotes al.
T2898 3173-3175 FW denotes et
T2897 3165-3172 NNP denotes Pollack
T2896 3164-3165 -LRB- denotes (
T2856 2934-2937 FW denotes al.
T2855 2931-2933 FW denotes et
T2854 2922-2930 NNP denotes Fujikane
T2853 2921-2922 -LRB- denotes (
T2852 2911-2920 NN denotes apoptosis
T2851 2896-2910 JJ denotes lesion-induced
T2850 2879-2895 JJ denotes O6-methylguanine
T2849 2875-2878 DT denotes the
T2848 2872-2874 IN denotes in
T2847 2859-2871 VBZ denotes participates
T2846 2854-2858 NN denotes gene
T2845 2852-2853 -RRB- denotes )
T2844 2844-2852 NNP denotes C1orf201
T2843 2843-2844 -LRB- denotes (
T2842 2837-2842 NNP denotes MAPO2
T2841 2835-2836 , denotes ,
T2840 2831-2835 RB denotes Also
T2839 2829-2830 . denotes .
T2838 2828-2829 -RRB- denotes )
T2837 2824-2828 CD denotes 2013
T2836 2822-2823 , denotes ,
T2835 2819-2822 FW denotes al.
T2834 2816-2818 FW denotes et
T2833 2807-2815 NNP denotes Knizhnik
T2832 2806-2807 -LRB- denotes (
T2831 2800-2805 NNS denotes cells
T2830 2796-2799 NNP denotes GBM
T2829 2793-2795 IN denotes in
T2828 2783-2792 NN denotes apoptosis
T2827 2774-2782 JJ denotes eventual
T2826 2770-2773 DT denotes the
T2825 2764-2769 VB denotes block
T2824 2760-2763 MD denotes may
T2823 2756-2759 CC denotes and
T2822 2754-2755 , denotes ,
T2821 2742-2754 JJ denotes pro-survival
T2820 2739-2741 VBZ denotes is
T2819 2729-2738 NN denotes autophagy
T2818 2717-2728 JJ denotes TMZ-induced
T2817 2712-2716 IN denotes that
T2816 2699-2711 VBD denotes demonstrated
T2815 2693-2698 NN denotes study
T2814 2686-2692 JJ denotes recent
T2813 2684-2685 DT denotes a
T2812 2682-2683 , denotes ,
T2811 2675-2682 RB denotes However
T2810 2673-2674 . denotes .
T2809 2672-2673 -RRB- denotes )
T2808 2668-2672 CD denotes 2010
T2807 2666-2667 , denotes ,
T2806 2663-2666 FW denotes al.
T2805 2660-2662 FW denotes et
T2804 2655-2659 NNP denotes Voss
T2803 2654-2655 -LRB- denotes (
T3116 4324-4326 TO denotes to
T3115 4316-4323 NNS denotes cancers
T3114 4307-4315 JJ denotes advanced
T3113 4304-4306 IN denotes of
T3112 4293-4303 NN denotes resistance
T2802 2650-2653 NNP denotes TMZ
T2801 2647-2649 IN denotes of
T2800 2640-2646 NN denotes action
T2799 2636-2639 DT denotes the
T2798 2627-2635 VBZ denotes enhances
T2797 2623-2626 CC denotes and
T2796 2615-2622 NNS denotes gliomas
T2795 2612-2614 IN denotes in
T2794 2606-2611 NN denotes death
T2793 2595-2605 JJ denotes autophagic
T2792 2592-2594 TO denotes to
T2791 2586-2591 VBZ denotes leads
T2790 2577-2585 NN denotes gossypol
T2789 2576-2577 : denotes -
T2788 2575-2576 -RRB- denotes )
T2787 2574-2575 FW denotes −
T2786 2573-2574 -LRB- denotes (
T2785 2563-2572 NN denotes inhibitor
T2784 2553-2562 NN denotes pan-Bcl-2
T2783 2551-2552 DT denotes a
T2782 2548-2550 IN denotes by
T2781 2542-2547 NN denotes Bcl-2
T2780 2528-2541 JJ denotes antiapoptotic
T2779 2525-2527 IN denotes of
T2778 2514-2524 NN denotes inhibition
T2777 2512-2513 , denotes ,
T2776 2508-2512 RB denotes Also
T2775 2506-2507 . denotes .
T2774 2505-2506 -RRB- denotes )
T2773 2501-2505 CD denotes 2003
T2772 2499-2500 , denotes ,
T2771 2496-2499 FW denotes al.
T2770 2493-2495 FW denotes et
T2769 2485-2492 NNP denotes Kanzawa
T2768 2484-2485 -LRB- denotes (
T2767 2478-2483 NN denotes death
T2766 2473-2477 NN denotes cell
T2765 2467-2472 VB denotes cause
T2764 2464-2466 TO denotes to
T2763 2462-2463 , denotes ,
T2762 2453-2462 NN denotes apoptosis
T2761 2448-2452 IN denotes than
T2760 2441-2447 RB denotes rather
T2759 2439-2440 , denotes ,
T2758 2430-2439 NN denotes autophagy
T2757 2422-2429 VB denotes trigger
T2756 2419-2421 TO denotes to
T2755 2413-2418 VBN denotes known
T2754 2410-2412 VBZ denotes is
T2753 2403-2409 NN denotes lesion
T2752 2386-2402 JJ denotes O6-methylguanine
T2751 2382-2385 DT denotes The
T2750 2380-2381 . denotes .
T2749 2379-2380 -RRB- denotes )
T2748 2374-2379 JJ denotes 2012b
T2747 2372-2373 , denotes ,
T2746 2369-2372 FW denotes al.
T2745 2366-2368 FW denotes et
T2744 2360-2365 NNP denotes Zhang
T2743 2358-2359 : denotes ;
T2742 2354-2358 CD denotes 2011
T2741 2352-2353 , denotes ,
T2740 2349-2352 FW denotes al.
T2739 2346-2348 FW denotes et
T2738 2337-2345 NNP denotes Goellner
T2737 2336-2337 -LRB- denotes (
T2736 2319-2335 NNP denotes N7-methylguanine
T2735 2315-2318 CC denotes and
T2734 2313-2314 , denotes ,
T2733 2297-2313 NNP denotes N3-methyladenine
T2732 2295-2296 , denotes ,
T2731 2279-2295 NNP denotes O6-methylguanine
T2730 2269-2278 VBG denotes including
T2729 2267-2268 , denotes ,
T2728 2260-2267 NNS denotes lesions
T2727 2256-2259 NNP denotes DNA
T2726 2253-2255 IN denotes of
T2725 2242-2252 NN denotes generation
T2724 2234-2241 VBZ denotes induces
T2723 2221-2233 NNP denotes Temozolomide
T2722 2219-2220 . denotes .
T2721 2218-2219 -RRB- denotes )
T2720 2213-2218 JJ denotes 2012b
T2719 2211-2212 , denotes ,
T2718 2208-2211 FW denotes al.
T2717 2205-2207 FW denotes et
T2716 2199-2204 NNP denotes Zhang
T2715 2197-2198 : denotes ;
T2714 2193-2197 CD denotes 2012
T2713 2191-2192 , denotes ,
T2712 2188-2191 FW denotes al.
T2711 2185-2187 FW denotes et
T2710 2177-2184 NNP denotes Kohsaka
T2709 2175-2176 : denotes ;
T2708 2171-2175 CD denotes 2012
T2707 2169-2170 , denotes ,
T2706 2166-2169 FW denotes al.
T2705 2163-2165 FW denotes et
T2704 2155-2162 NNP denotes Kitange
T2703 2153-2154 : denotes ;
T2702 2149-2153 CD denotes 2012
T2701 2147-2148 , denotes ,
T2700 2139-2147 NNP denotes Bjerkvig
T2699 2135-2138 CC denotes and
T2698 2123-2134 NNP denotes Johannessen
T2697 2121-2122 : denotes ;
T2696 2117-2121 CD denotes 2012
T2695 2115-2116 , denotes ,
T2694 2112-2115 FW denotes al.
T2693 2109-2111 FW denotes et
T2692 2101-2108 NNP denotes Happold
T2691 2099-2100 : denotes ;
T2690 2095-2099 CD denotes 2012
T2689 2093-2094 , denotes ,
T2688 2090-2093 FW denotes al.
T2687 2087-2089 FW denotes et
T2686 2082-2086 NNP denotes Haar
T2685 2081-2082 -LRB- denotes (
T2684 2074-2080 NNS denotes others
T2683 2069-2073 JJ denotes many
T2682 2065-2068 CC denotes and
T2681 2063-2064 , denotes ,
T2680 2057-2063 NN denotes kinase
T2679 2051-2056 CD denotes STAT3
T2678 2049-2050 , denotes ,
T2677 2039-2049 NN denotes transition
T2676 2016-2038 JJ denotes epithelial-mesenchymal
T2675 2014-2015 , denotes ,
T2674 2001-2014 NN denotes deacetylation
T2673 1993-2000 NN denotes histone
T2672 1991-1992 , denotes ,
T2671 1984-1991 NN denotes hypoxia
T2670 1978-1983 IN denotes under
T2669 1972-1977 NNS denotes cells
T2668 1966-1971 NN denotes tumor
T2667 1964-1965 , denotes ,
T2666 1958-1964 NN denotes repair
T2665 1951-1957 NN denotes damage
T2664 1947-1950 NNP denotes DNA
T2663 1945-1946 , denotes ,
T2662 1939-1945 NN denotes efflux
T2661 1934-1938 NN denotes drug
T2660 1932-1933 , denotes ,
T2659 1923-1932 NNS denotes microRNAs
T2658 1921-1922 , denotes ,
T2657 1916-1921 NNS denotes cells
T2656 1911-1915 NN denotes stem
T2655 1904-1910 NN denotes cancer
T2654 1896-1903 VB denotes include
T2653 1892-1895 MD denotes may
T2652 1886-1891 WDT denotes which
T2651 1884-1885 , denotes ,
T2650 1874-1884 NN denotes resistance
T2649 1870-1873 NNP denotes TMZ
T2648 1866-1869 DT denotes the
T2647 1863-1865 IN denotes in
T2646 1854-1862 VBN denotes involved
T2645 1850-1853 VBP denotes are
T2644 1839-1849 NNS denotes mechanisms
T2643 1830-1838 JJ denotes Multiple
T2642 1828-1829 . denotes .
T2641 1827-1828 -RRB- denotes )
T2562 1424-1425 -LRB- denotes (
T2561 1422-1423 NN denotes %
T2560 1419-1422 CD denotes 9.8
T2559 1414-1418 RB denotes only
T2558 1411-1413 VBZ denotes is
T2557 1407-1410 NNP denotes GBM
T2556 1403-1406 IN denotes for
T2555 1398-1402 NN denotes rate
T2554 1389-1397 NN denotes survival
T2553 1382-1388 JJ denotes 5-year
T2552 1374-1381 JJ denotes overall
T2551 1370-1373 DT denotes the
T2550 1366-1369 CC denotes and
T2549 1364-1365 , denotes ,
T2548 1358-1364 NNS denotes months
T2547 1353-1357 CD denotes 14.6
T2546 1350-1352 VBZ denotes is
T2545 1339-1349 NN denotes expectancy
T2544 1330-1338 NN denotes survival
T2543 1322-1329 JJ denotes average
T2542 1318-1321 DT denotes the
T2541 1314-1317 CC denotes and
T2540 1312-1313 , denotes ,
T2539 1306-1312 JJ denotes lethal
T2538 1299-1305 RB denotes highly
T2537 1296-1298 VBZ denotes is
T2536 1294-1295 -RRB- denotes )
T2535 1291-1294 NNP denotes GBM
T2534 1290-1291 -LRB- denotes (
T2533 1277-1289 NNP denotes Glioblastoma
T2532 1275-1276 . denotes .
T2531 1274-1275 -RRB- denotes )
T2530 1270-1274 CD denotes 2012
T2529 1268-1269 , denotes ,
T2528 1265-1268 FW denotes al.
T2527 1262-1264 FW denotes et
T2526 1255-1261 NNP denotes Silber
T2525 1253-1254 : denotes ;
T2524 1249-1253 CD denotes 2009
T2523 1247-1248 , denotes ,
T2522 1244-1247 FW denotes al.
T2521 1241-1243 FW denotes et
T2520 1235-1240 NNP denotes Stupp
T2519 1233-1234 : denotes ;
T2518 1229-1233 CD denotes 2000
T2517 1227-1228 , denotes ,
T2516 1224-1227 FW denotes al.
T2515 1221-1223 FW denotes et
T2514 1212-1220 NNP denotes Friedman
T2513 1211-1212 -LRB- denotes (
T2512 1202-1210 RB denotes annually
T2511 1197-1201 NNP denotes U.S.
T2510 1193-1196 DT denotes the
T2509 1190-1192 IN denotes in
T2895 3162-3163 -RRB- denotes )
T2894 3158-3162 NNP denotes MGMT
T2893 3157-3158 -LRB- denotes (
T2892 3139-3156 NN denotes methyltransferase
T2891 3118-3138 NNP denotes O6-methylguanine-DNA
T2890 3115-3117 IN denotes by
T2889 3108-3114 NN denotes repair
T2888 3101-3107 JJ denotes direct
T2887 3097-3100 IN denotes for
T2886 3087-3096 NN denotes substrate
T2885 3085-3086 DT denotes a
T2884 3082-3084 VBZ denotes is
T2883 3075-3081 NN denotes lesion
T2882 3058-3074 JJ denotes O6-methylguanine
T2881 3054-3057 DT denotes The
T2880 3052-3053 . denotes .
T2879 3043-3052 NN denotes autophagy
T2878 3040-3042 IN denotes in
T2877 3031-3039 VBN denotes involved
T2876 3028-3030 VBZ denotes is
T2875 3023-3027 NN denotes gene
T2874 3018-3022 DT denotes this
T2873 3010-3017 IN denotes whether
T2872 2999-3009 VBN denotes determined
T2871 2995-2998 RB denotes not
T2870 2992-2994 VBZ denotes is
T2869 2989-2991 PRP denotes It
T2868 2987-2988 . denotes .
T2867 2980-2987 NN denotes protein
T2866 2973-2979 NN denotes 37-kDa
T2865 2967-2972 NN denotes novel
T2864 2965-2966 DT denotes a
T2863 2957-2964 VBZ denotes encodes
T2862 2952-2956 NN denotes gene
T2861 2946-2951 CD denotes MAPO2
T2860 2944-2945 . denotes .
T2859 2943-2944 -RRB- denotes )
T2858 2939-2943 CD denotes 2012
T2857 2937-2938 , denotes ,
T2508 1181-1189 NNS denotes patients
T2507 1177-1180 JJ denotes new
T2506 1170-1176 CD denotes 12,500
T2505 1161-1169 VBZ denotes afflicts
T2504 1150-1160 JJ denotes multiforme
T2503 1137-1149 NNP denotes Glioblastoma
T2640 1823-1827 CD denotes 2010
T2639 1821-1822 , denotes ,
T2638 1812-1821 NNP denotes Nishikawa
T2637 1810-1811 : denotes ;
T2636 1806-1810 CD denotes 2000
T2635 1804-1805 , denotes ,
T2634 1801-1804 FW denotes al.
T2633 1798-1800 FW denotes et
T2632 1789-1797 NNP denotes Friedman
T2631 1788-1789 -LRB- denotes (
T2630 1786-1787 -RRB- denotes )
T2629 1783-1786 NNP denotes TMZ
T2628 1782-1783 -LRB- denotes (
T2627 1769-1781 NN denotes temozolomide
T2626 1763-1768 NN denotes agent
T2625 1752-1762 NN denotes alkylating
T2624 1737-1751 JJ denotes monofunctional
T2623 1733-1736 DT denotes the
T2622 1728-1732 IN denotes with
T2621 1718-1727 NN denotes treatment
T2620 1714-1717 CC denotes and
T2619 1712-1713 , denotes ,
T2618 1703-1712 NN denotes radiation
T2617 1701-1702 , denotes ,
T2616 1694-1701 NN denotes surgery
T2615 1684-1693 NN denotes debulking
T2614 1676-1683 NN denotes maximum
T2613 1667-1675 VBZ denotes includes
T2612 1660-1666 RB denotes mainly
T2611 1656-1659 NNP denotes GBM
T2610 1652-1655 IN denotes for
T2609 1644-1651 NN denotes therapy
T2608 1635-1643 JJ denotes standard
T2607 1627-1634 JJ denotes current
T2606 1623-1626 DT denotes The
T2605 1621-1622 . denotes .
T2604 1620-1621 -RRB- denotes )
T2603 1616-1620 CD denotes 2012
T2602 1614-1615 , denotes ,
T2601 1611-1614 FW denotes al.
T2600 1608-1610 FW denotes et
T2599 1600-1607 NNP denotes Happold
T2598 1598-1599 : denotes ;
T2597 1594-1598 CD denotes 2012
T2596 1592-1593 , denotes ,
T2595 1589-1592 FW denotes al.
T2594 1586-1588 FW denotes et
T2593 1581-1585 NNP denotes Haar
T2592 1580-1581 -LRB- denotes (
T2591 1571-1579 NNS denotes patients
T2590 1568-1570 IN denotes in
T2589 1563-1567 VBN denotes seen
T2588 1552-1562 RB denotes frequently
T2587 1548-1551 VBP denotes are
T2586 1540-1547 NN denotes relapse
T2585 1533-1539 NN denotes cancer
T2584 1529-1532 CC denotes and
T2583 1518-1528 NNS denotes modalities
T2582 1506-1517 JJ denotes therapeutic
T2581 1498-1505 JJ denotes current
T2580 1495-1497 TO denotes to
T2579 1484-1494 NN denotes resistance
T2578 1481-1483 IN denotes of
T2577 1474-1480 NNS denotes levels
T2576 1469-1473 JJ denotes High
T2575 1467-1468 . denotes .
T2574 1466-1467 -RRB- denotes )
T2573 1462-1466 CD denotes 2009
T2572 1460-1461 , denotes ,
T2571 1457-1460 FW denotes al.
T2570 1454-1456 FW denotes et
T2569 1448-1453 NNP denotes Stupp
T2568 1446-1447 : denotes ;
T2567 1442-1446 CD denotes 2000
T2566 1440-1441 , denotes ,
T2565 1437-1440 FW denotes al.
T2564 1434-1436 FW denotes et
T2563 1425-1433 NNP denotes Friedman
T729 1076-1077 . denotes .
T728 1071-1076 NN denotes death
T727 1066-1070 NN denotes cell
T726 1062-1065 NNP denotes GBM
T725 1055-1061 VB denotes induce
T724 1051-1054 CC denotes and
T723 1040-1050 NN denotes resistance
T722 1036-1039 NNP denotes TMZ
T721 1027-1035 VB denotes overcome
T720 1024-1026 TO denotes to
T719 1017-1023 VBN denotes needed
T718 1014-1016 VBZ denotes is
T717 1003-1013 NN denotes deficiency
T716 992-1002 JJ denotes functional
T715 988-991 NN denotes p53
T713 976-981 NNS denotes drugs
T712 964-975 JJ denotes therapeutic
T711 961-963 IN denotes by
T710 950-960 NN denotes activation
T709 945-949 NNP denotes WWOX
T708 934-944 VBG denotes triggering
T707 929-933 IN denotes that
T706 921-928 VBP denotes propose
T705 918-920 PRP denotes We
T704 916-917 . denotes .
T703 912-916 NNP denotes WWOX
T702 909-911 IN denotes of
T701 900-908 NN denotes function
T700 890-899 JJ denotes apoptotic
T699 886-889 DT denotes the
T698 877-885 VBP denotes modulate
T697 875-876 , denotes ,
T696 867-875 NNS denotes isoforms
T695 864-866 CC denotes or
T694 862-863 , denotes ,
T693 859-862 NN denotes p53
T692 852-858 JJ denotes mutant
T691 848-851 CC denotes and
T690 843-847 NN denotes type
T689 838-842 JJ denotes wild
T688 833-837 WDT denotes that
T687 823-832 NNS denotes scenarios
T686 813-822 JJ denotes potential
T685 803-812 VB denotes postulate
T684 799-802 CC denotes and
T683 797-798 , denotes ,
T682 793-797 NNP denotes WWOX
T681 789-792 CC denotes and
T680 785-788 NN denotes p53
T679 782-784 IN denotes in
T678 772-781 NN denotes knowledge
T677 764-771 VBN denotes updated
T676 760-763 DT denotes the
T675 756-759 IN denotes for
T674 747-755 NN denotes overview
T673 744-746 DT denotes an
T672 736-743 VBP denotes provide
T671 733-735 PRP denotes we
T670 731-732 , denotes ,
T669 727-731 RB denotes Here
T668 725-726 . denotes .
T667 722-725 NN denotes p53
T666 717-721 NN denotes type
T665 712-716 JJ denotes wild
T664 702-711 VB denotes stabilize
T663 698-701 CC denotes and
T662 693-697 NN denotes bind
T661 682-692 RB denotes physically
T660 679-681 TO denotes to
T659 673-678 VBN denotes known
T658 670-672 VBZ denotes is
T657 665-669 NNP denotes WWOX
T656 663-664 . denotes .
T655 660-663 NN denotes p53
T654 653-659 JJ denotes mutant
T653 643-652 VBG denotes harboring
T652 637-642 NNS denotes cells
T651 624-636 NN denotes glioblastoma
T650 618-623 JJ denotes human
T649 615-617 IN denotes in
T648 605-614 NN denotes apoptosis
T647 597-604 VBZ denotes induces
T646 582-596 RB denotes preferentially
T645 577-581 NNP denotes WWOX
T644 572-576 NN denotes type
T643 567-571 JJ denotes wild
T642 564-566 IN denotes of
T641 553-563 NN denotes expression
T640 545-552 JJ denotes ectopic
T639 543-544 , denotes ,
T638 531-543 RB denotes Intriguingly
T637 529-530 . denotes .
T636 521-529 NN denotes blockade
T635 507-520 JJ denotes translational
T634 503-506 CC denotes and
T633 501-502 , denotes ,
T632 490-501 NNS denotes alterations
T631 482-489 JJ denotes genetic
T630 480-481 , denotes ,
T629 464-480 NN denotes hypermethylation
T628 455-463 NN denotes promoter
T627 452-454 TO denotes to
T626 448-451 JJ denotes due
T625 442-447 NNS denotes cells
T624 435-441 NN denotes cancer
T623 425-434 JJ denotes malignant
T622 422-424 IN denotes in
T621 417-421 VBN denotes seen
T620 406-416 RB denotes frequently
T619 403-405 VBZ denotes is
T618 392-402 NN denotes expression
T616 382-386 NNP denotes WWOX
T615 379-381 IN denotes of
T614 374-378 NN denotes Loss
T613 372-373 . denotes .
T612 362-372 NN denotes suppressor
T611 356-361 NN denotes tumor
T610 354-355 DT denotes a
T609 351-353 IN denotes as
T608 340-350 VBN denotes considered
T607 337-339 VBZ denotes is
T606 333-336 CC denotes and
T605 325-332 NN denotes protein
T604 312-324 JJ denotes proapoptotic
T603 310-311 DT denotes a
T602 307-309 VBZ denotes is
T601 305-306 -RRB- denotes )
T600 301-305 CD denotes WOX1
T599 298-300 CC denotes or
T598 294-297 IN denotes FOR
T597 293-294 -LRB- denotes (
T596 288-292 NNP denotes WWOX
T595 273-287 NN denotes oxidoreductase
T594 255-272 JJ denotes domain-containing
T593 252-254 NNP denotes WW
T592 250-251 . denotes .
T591 245-250 NNS denotes drugs
T590 233-244 JJ denotes therapeutic
T589 229-232 CC denotes and
T588 227-228 -RRB- denotes )
T587 224-227 NNP denotes TMZ
T586 223-224 -LRB- denotes (
T585 210-222 VB denotes temozolomide
T584 207-209 TO denotes to
T583 196-206 NN denotes resistance
T582 193-195 TO denotes to
T581 191-192 , denotes ,
T580 187-191 NN denotes part
T579 184-186 IN denotes in
T578 182-183 , denotes ,
T577 172-182 VB denotes contribute
T576 169-171 TO denotes to
T575 161-168 VBZ denotes appears
T574 157-160 CC denotes and
T573 155-156 -RRB- denotes )
T572 151-155 NNS denotes GBMs
T571 150-151 -LRB- denotes (
T570 136-149 NNS denotes glioblastomas
T569 133-135 IN denotes in
T568 125-132 VBN denotes mutated
T567 114-124 RB denotes frequently
T566 110-113 VBP denotes are
T565 106-109 NN denotes p53
T564 95-105 NN denotes suppressor
T563 89-94 NNP denotes Tumor
T12956 8992-9002 VBG denotes relocating
T12955 8989-8991 IN denotes by
T12954 8980-8988 VBN denotes followed
T12953 8978-8979 , denotes ,
T12952 8971-8978 NN denotes complex
T12951 8969-8970 DT denotes a
T12950 8963-8968 NNS denotes forms
T12949 8959-8962 CC denotes and
T12948 8952-8958 NNP denotes Hyal-2
T12947 8946-8951 VBZ denotes binds
T12946 8941-8945 NNP denotes WWOX
T12945 8939-8940 , denotes ,
T12944 8933-8939 NNP denotes TGF-β1
T12943 8930-8932 TO denotes to
T12942 8921-8929 NN denotes response
T12941 8918-8920 IN denotes In
T12940 8916-8917 . denotes .
T11244 18161-18167 VBP denotes induce
T11243 18156-18160 WDT denotes that
T11242 18146-18155 NNS denotes molecules
T11241 18140-18145 JJ denotes small
T11240 18132-18139 JJ denotes certain
T11239 18123-18131 VBN denotes selected
T11238 18118-18122 VBP denotes have
T11237 18108-18117 NNS denotes chemicals
T11236 18105-18107 IN denotes of
T11235 18095-18104 NN denotes screening
T11234 18091-18094 PRP$ denotes our
T11233 18086-18090 IN denotes from
T11232 18078-18085 NNS denotes studies
T11231 18066-18077 JJ denotes Preliminary
T11230 18064-18065 . denotes .
T11229 18059-18064 NN denotes death
T11228 18054-18058 NN denotes cell
T11227 18050-18053 NNP denotes GBM
T11226 18044-18049 VB denotes cause
T11225 18041-18043 TO denotes to
T11224 18032-18040 VBN denotes expected
T11223 18028-18031 VBP denotes are
T11222 18026-18027 , denotes ,
T11221 18019-18026 NN denotes complex
T11220 18010-18018 NNP denotes WWOX/MEK
T11219 18006-18009 DT denotes the
T11218 18000-18005 RP denotes apart
T11217 17994-17999 VBP denotes break
T11216 17988-17993 WDT denotes which
T11215 17986-17987 , denotes ,
T11214 17977-17986 NNS denotes chemicals
T11213 17965-17976 JJ denotes appropriate
T11259 17963-17964 , denotes ,
T11258 17959-17963 RB denotes Thus
T11257 17957-17958 . denotes .
T11256 17956-17957 -RRB- denotes )
T11255 17952-17956 CD denotes 2011
T11254 17950-17951 , denotes ,
T11253 17947-17950 FW denotes al.
T11252 17944-17946 FW denotes et
T11251 17940-17943 NNP denotes Lin
T11250 17939-17940 -LRB- denotes (
T11249 17933-17938 NNS denotes cells
T11248 17924-17932 NN denotes leukemia
T11247 17922-17923 NNP denotes T
T11246 17919-17921 IN denotes of
T11245 17909-17918 NN denotes apoptosis
T13872 8382-8387 JJ denotes first
T12125 20970-20972 IN denotes In
T5771 6676-6684 RB denotes Recently
T617 387-391 NN denotes gene
T714 982-987 IN denotes under
R395 T683 T682 punct ",",WWOX
R265 T552 T554 compound Tumor,WWOX
R266 T553 T554 compound Suppressor,WWOX
R267 T554 T568 nsubjpass WWOX,mutated
R268 T555 T554 cc and,WWOX
R269 T556 T557 compound p53,Alterations
R270 T557 T554 conj Alterations,WWOX
R271 T558 T557 cc and,Alterations
R272 T559 T560 compound Drug,Resistance
R273 T560 T557 conj Resistance,Alterations
R274 T561 T557 prep in,Alterations
R275 T562 T565 compound Glioblastomas,p53
R276 T563 T565 compound Tumor,p53
R277 T564 T565 compound suppressor,p53
R278 T565 T561 pobj p53,in
R279 T566 T568 auxpass are,mutated
R280 T567 T568 advmod frequently,mutated
R281 T568 T568 ROOT mutated,mutated
R282 T569 T568 prep in,mutated
R283 T570 T569 pobj glioblastomas,in
R284 T571 T572 punct (,GBMs
R285 T572 T570 appos GBMs,glioblastomas
R286 T573 T568 punct ),mutated
R287 T574 T568 cc and,mutated
R288 T575 T568 conj appears,mutated
R289 T576 T577 aux to,contribute
R290 T577 T575 xcomp contribute,appears
R291 T578 T577 punct ",",contribute
R292 T579 T575 prep in,appears
R293 T580 T579 pobj part,in
R294 T581 T575 punct ",",appears
R295 T582 T583 aux to,resistance
R296 T583 T568 advcl resistance,mutated
R297 T584 T585 aux to,temozolomide
R298 T585 T583 advcl temozolomide,resistance
R299 T586 T587 punct (,TMZ
R300 T587 T585 appos TMZ,temozolomide
R301 T588 T587 punct ),TMZ
R302 T589 T585 cc and,temozolomide
R303 T590 T591 amod therapeutic,drugs
R304 T591 T585 conj drugs,temozolomide
R305 T592 T568 punct .,mutated
R306 T593 T596 compound WW,WWOX
R307 T594 T596 compound domain-containing,WWOX
R308 T595 T596 compound oxidoreductase,WWOX
R309 T596 T602 nsubj WWOX,is
R310 T597 T598 punct (,FOR
R311 T598 T596 prep FOR,WWOX
R312 T599 T598 cc or,FOR
R313 T600 T598 conj WOX1,FOR
R314 T601 T598 punct ),FOR
R315 T602 T602 ROOT is,is
R316 T603 T605 det a,protein
R317 T604 T605 amod proapoptotic,protein
R318 T605 T602 attr protein,is
R319 T606 T602 cc and,is
R320 T607 T608 auxpass is,considered
R321 T608 T602 conj considered,is
R322 T609 T608 prep as,considered
R323 T610 T612 det a,suppressor
R324 T611 T612 compound tumor,suppressor
R325 T612 T609 pobj suppressor,as
R326 T613 T602 punct .,is
R327 T614 T621 nsubjpass Loss,seen
R328 T615 T614 prep of,Loss
R329 T616 T618 compound WWOX,expression
R330 T618 T615 pobj expression,of
R331 T619 T621 auxpass is,seen
R332 T620 T621 advmod frequently,seen
R333 T621 T621 ROOT seen,seen
R334 T622 T621 prep in,seen
R335 T623 T625 amod malignant,cells
R336 T624 T625 compound cancer,cells
R337 T625 T622 pobj cells,in
R338 T626 T621 prep due,seen
R339 T627 T628 aux to,promoter
R340 T628 T626 xcomp promoter,due
R341 T629 T626 conj hypermethylation,due
R342 T630 T629 punct ",",hypermethylation
R343 T631 T632 amod genetic,alterations
R344 T632 T629 conj alterations,hypermethylation
R345 T633 T632 punct ",",alterations
R346 T634 T632 cc and,alterations
R347 T635 T636 amod translational,blockade
R348 T636 T632 conj blockade,alterations
R349 T637 T621 punct .,seen
R350 T638 T647 advmod Intriguingly,induces
R351 T639 T641 punct ",",expression
R352 T640 T641 amod ectopic,expression
R353 T641 T647 nsubj expression,induces
R354 T642 T641 prep of,expression
R355 T643 T644 amod wild,type
R356 T644 T645 compound type,WWOX
R357 T645 T642 pobj WWOX,of
R358 T646 T647 advmod preferentially,induces
R359 T647 T647 ROOT induces,induces
R360 T648 T647 dobj apoptosis,induces
R361 T649 T648 prep in,apoptosis
R362 T650 T652 amod human,cells
R363 T651 T652 compound glioblastoma,cells
R364 T652 T649 pobj cells,in
R365 T653 T648 acl harboring,apoptosis
R366 T654 T655 amod mutant,p53
R367 T655 T653 dobj p53,harboring
R368 T656 T647 punct .,induces
R369 T657 T659 nsubjpass WWOX,known
R370 T658 T659 auxpass is,known
R371 T659 T659 ROOT known,known
R372 T660 T662 aux to,bind
R373 T661 T662 advmod physically,bind
R374 T662 T659 xcomp bind,known
R375 T663 T659 cc and,known
R376 T664 T659 conj stabilize,known
R377 T665 T666 amod wild,type
R378 T666 T667 compound type,p53
R379 T667 T664 dobj p53,stabilize
R380 T668 T659 punct .,known
R381 T669 T672 advmod Here,provide
R382 T670 T672 punct ",",provide
R383 T671 T672 nsubj we,provide
R384 T672 T672 ROOT provide,provide
R385 T673 T674 det an,overview
R386 T674 T672 dobj overview,provide
R387 T675 T674 prep for,overview
R388 T676 T678 det the,knowledge
R389 T677 T678 amod updated,knowledge
R390 T678 T675 pobj knowledge,for
R391 T679 T678 prep in,knowledge
R392 T680 T679 pobj p53,in
R393 T681 T680 cc and,p53
R394 T682 T680 conj WWOX,p53
R396 T684 T672 cc and,provide
R397 T685 T672 conj postulate,provide
R398 T686 T687 amod potential,scenarios
R399 T687 T685 dobj scenarios,postulate
R400 T688 T698 nsubj that,modulate
R401 T689 T690 amod wild,type
R402 T690 T698 nsubj type,modulate
R403 T691 T690 cc and,type
R404 T692 T693 amod mutant,p53
R405 T693 T690 conj p53,type
R406 T694 T693 punct ",",p53
R407 T695 T693 cc or,p53
R408 T696 T693 conj isoforms,p53
R409 T697 T698 punct ",",modulate
R410 T698 T687 relcl modulate,scenarios
R411 T699 T701 det the,function
R412 T700 T701 amod apoptotic,function
R413 T701 T698 dobj function,modulate
R414 T702 T701 prep of,function
R415 T703 T702 pobj WWOX,of
R416 T704 T672 punct .,provide
R417 T705 T706 nsubj We,propose
R418 T706 T706 ROOT propose,propose
R419 T707 T719 mark that,needed
R420 T708 T719 csubj triggering,needed
R421 T709 T710 compound WWOX,activation
R422 T710 T708 dobj activation,triggering
R423 T711 T710 prep by,activation
R424 T712 T713 amod therapeutic,drugs
R425 T713 T711 pobj drugs,by
R426 T715 T717 amod p53,deficiency
R427 T716 T717 amod functional,deficiency
R428 T717 T714 pobj deficiency,under
R429 T718 T719 auxpass is,needed
R430 T719 T706 ccomp needed,propose
R431 T720 T721 aux to,overcome
R432 T721 T719 advcl overcome,needed
R433 T722 T723 compound TMZ,resistance
R434 T723 T721 dobj resistance,overcome
R435 T724 T721 cc and,overcome
R436 T725 T721 conj induce,overcome
R437 T726 T728 compound GBM,death
R438 T727 T728 compound cell,death
R439 T728 T725 dobj death,induce
R440 T729 T706 punct .,propose
R442 T617 T618 compound gene,expression
R443 T714 T710 prep under,activation
R1576 T2518 T2516 npadvmod 2000,al.
R1577 T2519 T2516 punct ;,al.
R1578 T2520 T2522 compound Stupp,al.
R1579 T2521 T2522 compound et,al.
R1580 T2503 T2504 compound Glioblastoma,multiforme
R1581 T2522 T2505 prep al.,afflicts
R1582 T2504 T2505 nsubj multiforme,afflicts
R1583 T2505 T2528 ccomp afflicts,al.
R1584 T2523 T2522 punct ",",al.
R1585 T2506 T2508 nummod "12,500",patients
R1586 T2524 T2522 npadvmod 2009,al.
R1587 T2507 T2508 amod new,patients
R1588 T2508 T2505 dobj patients,afflicts
R1589 T2509 T2508 prep in,patients
R1590 T2510 T2511 det the,U.S.
R1591 T2525 T2528 punct ;,al.
R1592 T2511 T2509 pobj U.S.,in
R1593 T2512 T2505 advmod annually,afflicts
R1594 T2526 T2528 compound Silber,al.
R1595 T2527 T2528 compound et,al.
R1596 T2528 T2528 ROOT al.,al.
R1597 T2513 T2516 punct (,al.
R1598 T2529 T2528 punct ",",al.
R1599 T2514 T2516 nmod Friedman,al.
R1600 T2515 T2516 nmod et,al.
R1601 T2530 T2528 npadvmod 2012,al.
R1602 T2516 T2522 compound al.,al.
R1603 T2517 T2516 punct ",",al.
R1604 T2531 T2528 punct ),al.
R1605 T2532 T2528 punct .,al.
R1606 T2533 T2537 nsubj Glioblastoma,is
R1607 T2534 T2535 punct (,GBM
R1608 T2570 T2571 compound et,al.
R1609 T2571 T2558 attr al.,is
R1610 T2535 T2533 appos GBM,Glioblastoma
R1611 T2572 T2571 punct ",",al.
R1612 T2573 T2571 npadvmod 2009,al.
R1613 T2574 T2558 punct ),is
R1614 T2536 T2533 punct ),Glioblastoma
R1615 T2575 T2546 punct .,is
R1616 T2576 T2577 amod High,levels
R1617 T2537 T2537 ROOT is,is
R1618 T2577 T2589 nsubjpass levels,seen
R1619 T2578 T2577 prep of,levels
R1620 T2579 T2578 pobj resistance,of
R1621 T2538 T2539 advmod highly,lethal
R1622 T2580 T2579 prep to,resistance
R1623 T2581 T2583 amod current,modalities
R1624 T2582 T2583 amod therapeutic,modalities
R1625 T2539 T2537 acomp lethal,is
R1626 T2583 T2580 pobj modalities,to
R1627 T2584 T2583 cc and,modalities
R1628 T2585 T2586 compound cancer,relapse
R1629 T2586 T2583 conj relapse,modalities
R1630 T2540 T2537 punct ",",is
R1631 T2587 T2589 auxpass are,seen
R1632 T2588 T2589 advmod frequently,seen
R1633 T2541 T2537 cc and,is
R1634 T2589 T2601 ccomp seen,al.
R1635 T2542 T2545 det the,expectancy
R1636 T2590 T2589 prep in,seen
R1637 T2543 T2545 amod average,expectancy
R1638 T2591 T2590 pobj patients,in
R1639 T2544 T2545 compound survival,expectancy
R1640 T2545 T2546 nsubj expectancy,is
R1641 T2592 T2595 punct (,al.
R1642 T2546 T2537 conj is,is
R1643 T2593 T2595 nmod Haar,al.
R1644 T2594 T2595 nmod et,al.
R1645 T2595 T2601 dep al.,al.
R1646 T2547 T2548 nummod 14.6,months
R1647 T2596 T2595 punct ",",al.
R1648 T2597 T2595 npadvmod 2012,al.
R1649 T2548 T2546 attr months,is
R1650 T2598 T2601 punct ;,al.
R1651 T2599 T2601 compound Happold,al.
R1652 T2600 T2601 compound et,al.
R1653 T2549 T2546 punct ",",is
R1654 T2601 T2601 ROOT al.,al.
R1655 T2602 T2601 punct ",",al.
R1656 T2603 T2601 npadvmod 2012,al.
R1657 T2604 T2601 punct ),al.
R1658 T2605 T2601 punct .,al.
R1659 T2606 T2609 det The,therapy
R1660 T2550 T2546 cc and,is
R1661 T2607 T2609 amod current,therapy
R1662 T2608 T2609 amod standard,therapy
R1663 T2609 T2613 nsubj therapy,includes
R1664 T2551 T2555 det the,rate
R1665 T2610 T2609 prep for,therapy
R1666 T2611 T2610 pobj GBM,for
R1667 T2612 T2613 advmod mainly,includes
R1668 T2552 T2555 amod overall,rate
R1669 T2613 T2613 ROOT includes,includes
R1670 T2614 T2616 amod maximum,surgery
R1671 T2615 T2616 compound debulking,surgery
R1672 T2553 T2555 amod 5-year,rate
R1673 T2616 T2613 dobj surgery,includes
R1674 T2617 T2616 punct ",",surgery
R1675 T2618 T2616 conj radiation,surgery
R1676 T2554 T2555 compound survival,rate
R1677 T2619 T2618 punct ",",radiation
R1678 T2620 T2618 cc and,radiation
R1679 T2555 T2558 nsubj rate,is
R1680 T2621 T2618 conj treatment,radiation
R1681 T2622 T2616 prep with,surgery
R1682 T2623 T2626 det the,agent
R1683 T2624 T2626 amod monofunctional,agent
R1684 T2556 T2555 prep for,rate
R1685 T2625 T2626 amod alkylating,agent
R1686 T2626 T2627 compound agent,temozolomide
R1687 T2627 T2622 pobj temozolomide,with
R1688 T2557 T2556 pobj GBM,for
R1689 T2628 T2627 punct (,temozolomide
R1690 T2629 T2627 appos TMZ,temozolomide
R1691 T2558 T2546 conj is,is
R1692 T2630 T2627 punct ),temozolomide
R1693 T2631 T2634 punct (,al.
R1694 T2632 T2634 compound Friedman,al.
R1695 T2559 T2560 advmod only,9.8
R1696 T2633 T2634 nmod et,al.
R1697 T2634 T2638 compound al.,Nishikawa
R1698 T2560 T2561 nummod 9.8,%
R1699 T2635 T2634 punct ",",al.
R1700 T2636 T2634 dep 2000,al.
R1701 T2637 T2634 punct ;,al.
R1702 T2561 T2558 attr %,is
R1703 T2638 T2616 appos Nishikawa,surgery
R1704 T2639 T2638 punct ",",Nishikawa
R1705 T2640 T2638 npadvmod 2010,Nishikawa
R1706 T2641 T2638 punct ),Nishikawa
R1707 T2642 T2613 punct .,includes
R1708 T2643 T2644 amod Multiple,mechanisms
R1709 T2562 T2565 punct (,al.
R1710 T2644 T2646 nsubjpass mechanisms,involved
R1711 T2645 T2646 auxpass are,involved
R1712 T2646 T2718 ccomp involved,al.
R1713 T2647 T2646 prep in,involved
R1714 T2563 T2565 compound Friedman,al.
R1715 T2648 T2650 det the,resistance
R1716 T2649 T2650 compound TMZ,resistance
R1717 T2650 T2647 pobj resistance,in
R1718 T2564 T2565 nmod et,al.
R1719 T2651 T2650 punct ",",resistance
R1720 T2652 T2654 nsubj which,include
R1721 T2653 T2654 aux may,include
R1722 T2565 T2558 parataxis al.,is
R1723 T2654 T2650 relcl include,resistance
R1724 T2655 T2657 compound cancer,cells
R1725 T2656 T2657 compound stem,cells
R1726 T2566 T2565 punct ",",al.
R1727 T2657 T2654 dobj cells,include
R1728 T2658 T2657 punct ",",cells
R1729 T2659 T2657 conj microRNAs,cells
R1730 T2567 T2565 npadvmod 2000,al.
R1731 T2660 T2659 punct ",",microRNAs
R1732 T2661 T2662 compound drug,efflux
R1733 T2662 T2659 conj efflux,microRNAs
R1734 T2663 T2662 punct ",",efflux
R1735 T2568 T2558 punct ;,is
R1736 T2664 T2666 compound DNA,repair
R1737 T2665 T2666 compound damage,repair
R1738 T2666 T2662 conj repair,efflux
R1739 T2569 T2571 compound Stupp,al.
R1740 T2764 T2765 aux to,cause
R1741 T2667 T2666 punct ",",repair
R1742 T2668 T2669 compound tumor,cells
R1743 T2765 T2757 advcl cause,trigger
R1744 T2669 T2659 conj cells,microRNAs
R1745 T2766 T2767 compound cell,death
R1746 T2670 T2654 prep under,include
R1747 T2767 T2765 dobj death,cause
R1748 T2671 T2670 pobj hypoxia,under
R1749 T2768 T2765 punct (,cause
R1750 T2769 T2771 compound Kanzawa,al.
R1751 T2672 T2671 punct ",",hypoxia
R1752 T2770 T2771 nmod et,al.
R1753 T2673 T2674 compound histone,deacetylation
R1754 T2674 T2671 appos deacetylation,hypoxia
R1755 T2675 T2674 punct ",",deacetylation
R1756 T2676 T2677 amod epithelial-mesenchymal,transition
R1757 T2677 T2674 appos transition,deacetylation
R1758 T2678 T2677 punct ",",transition
R1759 T2679 T2680 nummod STAT3,kinase
R1760 T2771 T2765 advmod al.,cause
R1761 T2680 T2677 conj kinase,transition
R1762 T2681 T2680 punct ",",kinase
R1763 T2772 T2771 punct ",",al.
R1764 T2682 T2680 cc and,kinase
R1765 T2683 T2684 amod many,others
R1766 T2684 T2680 conj others,kinase
R1767 T2773 T2771 npadvmod 2003,al.
R1768 T2685 T2684 punct (,others
R1769 T2686 T2688 compound Haar,al.
R1770 T2687 T2688 nmod et,al.
R1771 T2774 T2771 punct ),al.
R1772 T2688 T2684 appos al.,others
R1773 T2689 T2688 punct ",",al.
R1774 T2775 T2755 punct .,known
R1775 T2690 T2688 npadvmod 2012,al.
R1776 T2691 T2684 punct ;,others
R1777 T2692 T2694 compound Happold,al.
R1778 T2776 T2791 advmod Also,leads
R1779 T2693 T2694 compound et,al.
R1780 T2694 T2684 conj al.,others
R1781 T2695 T2694 punct ",",al.
R1782 T2777 T2791 punct ",",leads
R1783 T2696 T2694 npadvmod 2012,al.
R1784 T2697 T2718 punct ;,al.
R1785 T2698 T2718 dep Johannessen,al.
R1786 T2778 T2791 nsubj inhibition,leads
R1787 T2699 T2698 cc and,Johannessen
R1788 T2700 T2698 conj Bjerkvig,Johannessen
R1789 T2701 T2700 punct ",",Bjerkvig
R1790 T2702 T2700 npadvmod 2012,Bjerkvig
R1791 T2779 T2778 prep of,inhibition
R1792 T2703 T2700 punct ;,Bjerkvig
R1793 T2704 T2706 compound Kitange,al.
R1794 T2705 T2706 compound et,al.
R1795 T2780 T2781 amod antiapoptotic,Bcl-2
R1796 T2706 T2700 conj al.,Bjerkvig
R1797 T2707 T2706 punct ",",al.
R1798 T2708 T2706 npadvmod 2012,al.
R1799 T2781 T2779 pobj Bcl-2,of
R1800 T2709 T2718 punct ;,al.
R1801 T2710 T2712 compound Kohsaka,al.
R1802 T2711 T2712 compound et,al.
R1803 T2782 T2778 prep by,inhibition
R1804 T2712 T2718 ccomp al.,al.
R1805 T2713 T2712 punct ",",al.
R1806 T2714 T2712 npadvmod 2012,al.
R1807 T2715 T2718 punct ;,al.
R1808 T2716 T2718 compound Zhang,al.
R1809 T2717 T2718 nmod et,al.
R1810 T2783 T2785 det a,inhibitor
R1811 T2718 T2718 ROOT al.,al.
R1812 T2719 T2720 punct ",",2012b
R1813 T2784 T2785 compound pan-Bcl-2,inhibitor
R1814 T2720 T2718 amod 2012b,al.
R1815 T2785 T2782 pobj inhibitor,by
R1816 T2721 T2720 punct ),2012b
R1817 T2722 T2718 punct .,al.
R1818 T2723 T2724 nsubj Temozolomide,induces
R1819 T2786 T2787 punct (,−
R1820 T2724 T2746 ccomp induces,al.
R1821 T2725 T2724 dobj generation,induces
R1822 T2787 T2785 appos −,inhibitor
R1823 T2726 T2725 prep of,generation
R1824 T2727 T2728 compound DNA,lesions
R1825 T2728 T2726 pobj lesions,of
R1826 T2729 T2728 punct ",",lesions
R1827 T2788 T2787 punct ),−
R1828 T2730 T2728 prep including,lesions
R1829 T2731 T2730 pobj O6-methylguanine,including
R1830 T2789 T2791 punct -,leads
R1831 T2732 T2731 punct ",",O6-methylguanine
R1832 T2733 T2731 conj N3-methyladenine,O6-methylguanine
R1833 T2734 T2733 punct ",",N3-methyladenine
R1834 T2790 T2791 nsubj gossypol,leads
R1835 T2735 T2733 cc and,N3-methyladenine
R1836 T2736 T2733 conj N7-methylguanine,N3-methyladenine
R1837 T2737 T2740 punct (,al.
R1838 T2791 T2791 ROOT leads,leads
R1839 T2738 T2740 compound Goellner,al.
R1840 T2739 T2740 nmod et,al.
R1841 T2740 T2731 appos al.,O6-methylguanine
R1842 T2792 T2791 prep to,leads
R1843 T2741 T2740 punct ",",al.
R1844 T2742 T2740 npadvmod 2011,al.
R1845 T2793 T2792 pobj autophagic,to
R1846 T2743 T2746 punct ;,al.
R1847 T2744 T2746 compound Zhang,al.
R1848 T2745 T2746 compound et,al.
R1849 T2794 T2793 dobj death,autophagic
R1850 T2746 T2746 ROOT al.,al.
R1851 T2747 T2748 punct ",",2012b
R1852 T2795 T2793 prep in,autophagic
R1853 T2748 T2746 amod 2012b,al.
R1854 T2796 T2795 pobj gliomas,in
R1855 T2749 T2748 punct ),2012b
R1856 T2750 T2746 punct .,al.
R1857 T2751 T2753 det The,lesion
R1858 T2752 T2753 amod O6-methylguanine,lesion
R1859 T2797 T2791 cc and,leads
R1860 T2753 T2755 nsubjpass lesion,known
R1861 T2754 T2755 auxpass is,known
R1862 T2755 T2755 ROOT known,known
R1863 T2798 T2791 conj enhances,leads
R1864 T2756 T2757 aux to,trigger
R1865 T2757 T2755 xcomp trigger,known
R1866 T2758 T2757 dobj autophagy,trigger
R1867 T2759 T2758 punct ",",autophagy
R1868 T2760 T2761 advmod rather,than
R1869 T2799 T2800 det the,action
R1870 T2761 T2757 prep than,trigger
R1871 T2762 T2761 pobj apoptosis,than
R1872 T2763 T2757 punct ",",trigger
R1873 T2800 T2798 dobj action,enhances
R1874 T2801 T2800 prep of,action
R1875 T2802 T2801 pobj TMZ,of
R1876 T2803 T2806 punct (,al.
R1877 T2861 T2863 dep MAPO2,encodes
R1878 T2862 T2863 nsubj gene,encodes
R1879 T2804 T2806 compound Voss,al.
R1880 T2863 T2863 ROOT encodes,encodes
R1881 T2864 T2867 det a,protein
R1882 T2865 T2867 compound novel,protein
R1883 T2805 T2806 nmod et,al.
R1884 T2866 T2867 compound 37-kDa,protein
R1885 T2867 T2863 dobj protein,encodes
R1886 T2806 T2800 appos al.,action
R1887 T2868 T2863 punct .,encodes
R1888 T2869 T2872 nsubjpass It,determined
R1889 T2870 T2872 auxpass is,determined
R1890 T2871 T2872 neg not,determined
R1891 T2807 T2806 punct ",",al.
R1892 T2872 T2872 ROOT determined,determined
R1893 T2873 T2876 mark whether,is
R1894 T2874 T2875 det this,gene
R1895 T2808 T2806 npadvmod 2010,al.
R1896 T2875 T2876 nsubj gene,is
R1897 T2809 T2798 punct ),enhances
R1898 T2810 T2791 punct .,leads
R1899 T2876 T2877 auxpass is,involved
R1900 T2877 T2872 xcomp involved,determined
R1901 T2811 T2816 advmod However,demonstrated
R1902 T2878 T2877 prep in,involved
R1903 T2879 T2878 pobj autophagy,in
R1904 T2812 T2816 punct ",",demonstrated
R1905 T2880 T2872 punct .,determined
R1906 T2881 T2883 det The,lesion
R1907 T2882 T2883 amod O6-methylguanine,lesion
R1908 T2883 T2884 nsubj lesion,is
R1909 T2884 T2884 ROOT is,is
R1910 T2885 T2886 det a,substrate
R1911 T2813 T2815 det a,study
R1912 T2886 T2884 attr substrate,is
R1913 T2887 T2886 prep for,substrate
R1914 T2888 T2889 amod direct,repair
R1915 T2814 T2815 amod recent,study
R1916 T2889 T2887 pobj repair,for
R1917 T2815 T2816 nsubj study,demonstrated
R1918 T2816 T2816 ROOT demonstrated,demonstrated
R1919 T2890 T2889 prep by,repair
R1920 T2817 T2820 mark that,is
R1921 T2891 T2892 compound O6-methylguanine-DNA,methyltransferase
R1922 T2892 T2890 pobj methyltransferase,by
R1923 T2893 T2894 punct (,MGMT
R1924 T2818 T2819 amod TMZ-induced,autophagy
R1925 T2894 T2892 appos MGMT,methyltransferase
R1926 T2895 T2884 punct ),is
R1927 T2819 T2820 nsubj autophagy,is
R1928 T2896 T2899 punct (,al.
R1929 T2897 T2899 compound Pollack,al.
R1930 T2898 T2899 nmod et,al.
R1931 T2820 T2816 ccomp is,demonstrated
R1932 T2899 T2905 compound al.,al.
R1933 T2900 T2899 punct ",",al.
R1934 T2901 T2899 npadvmod 2006,al.
R1935 T2821 T2820 acomp pro-survival,is
R1936 T2902 T2899 punct ;,al.
R1937 T2903 T2905 compound Hegi,al.
R1938 T2904 T2905 compound et,al.
R1939 T2822 T2820 punct ",",is
R1940 T2905 T2905 ROOT al.,al.
R1941 T2906 T2905 punct ",",al.
R1942 T2823 T2820 cc and,is
R1943 T2824 T2825 aux may,block
R1944 T2907 T2905 npadvmod 2008,al.
R1945 T2908 T2905 punct ;,al.
R1946 T2825 T2820 conj block,is
R1947 T2909 T2911 compound Fukushima,al.
R1948 T2910 T2911 nmod et,al.
R1949 T2911 T2905 conj al.,al.
R1950 T2826 T2828 det the,apoptosis
R1951 T2912 T2911 punct ",",al.
R1952 T2913 T2911 npadvmod 2009,al.
R1953 T2827 T2828 amod eventual,apoptosis
R1954 T2914 T2917 punct ;,al.
R1955 T2915 T2917 compound Zhang,al.
R1956 T2916 T2917 nmod et,al.
R1957 T2917 T2884 attr al.,is
R1958 T2918 T2919 punct ",",2012b
R1959 T2828 T2825 dobj apoptosis,block
R1960 T2919 T2917 amod 2012b,al.
R1961 T2920 T2919 punct ),2012b
R1962 T2921 T2884 punct .,is
R1963 T2922 T2927 prep Without,initiates
R1964 T2923 T2924 compound MGMT,repair
R1965 T2829 T2825 prep in,block
R1966 T2924 T2922 pobj repair,Without
R1967 T2925 T2927 punct ",",initiates
R1968 T2926 T2927 nsubj O6-methylguanine,initiates
R1969 T2927 T2927 ROOT initiates,initiates
R1970 T2830 T2831 compound GBM,cells
R1971 T2928 T2927 dobj activation,initiates
R1972 T2929 T2928 prep of,activation
R1973 T2930 T2929 pobj mismatch,of
R1974 T2931 T2928 conj repair-deficient,activation
R1975 T2831 T2829 pobj cells,in
R1976 T2932 T2931 punct (,repair-deficient
R1977 T2933 T2935 nmod MMR,proteins
R1978 T2934 T2935 punct ),proteins
R1979 T2935 T2931 appos proteins,repair-deficient
R1980 T2832 T2835 punct (,al.
R1981 T2936 T2935 cc or,proteins
R1982 T2937 T2939 amod Rad3-related,kinase
R1983 T2833 T2835 compound Knizhnik,al.
R1984 T2938 T2939 compound protein,kinase
R1985 T2939 T2935 conj kinase,proteins
R1986 T2940 T2942 nsubj that,leads
R1987 T2834 T2835 nmod et,al.
R1988 T2941 T2942 advmod ultimately,leads
R1989 T2942 T2939 relcl leads,kinase
R1990 T2943 T2942 prep to,leads
R1991 T2835 T2825 parataxis al.,block
R1992 T2944 T2946 amod apoptotic,death
R1993 T2945 T2946 compound cell,death
R1994 T2946 T2943 pobj death,to
R1995 T2836 T2835 punct ",",al.
R1996 T2947 T2950 punct (,al.
R1997 T2948 T2950 compound Caporali,al.
R1998 T2949 T2950 nmod et,al.
R1999 T2837 T2835 npadvmod 2013,al.
R2000 T2950 T2939 appos al.,kinase
R2001 T2951 T2950 punct ",",al.
R2002 T2952 T2950 npadvmod 2004,al.
R2003 T2838 T2835 punct ),al.
R2004 T2953 T2927 punct ;,initiates
R2005 T2839 T2816 punct .,demonstrated
R2006 T2954 T2927 conj Wang,initiates
R2007 T2955 T2954 cc and,Wang
R2008 T2956 T2954 conj Edelmann,Wang
R2009 T2957 T2956 punct ",",Edelmann
R2010 T2840 T2847 advmod Also,participates
R2011 T2841 T2847 punct ",",participates
R2012 T2842 T2847 nsubj MAPO2,participates
R2013 T2958 T2954 npadvmod 2006,Wang
R2014 T2959 T2954 punct ;,Wang
R2015 T2843 T2842 punct (,MAPO2
R2016 T2960 T2962 compound Roos,al.
R2017 T2961 T2962 nmod et,al.
R2018 T2844 T2842 appos C1orf201,MAPO2
R2019 T2962 T2954 conj al.,Wang
R2020 T2963 T2962 punct ",",al.
R2021 T2964 T2962 npadvmod 2007,al.
R2022 T2845 T2842 punct ),MAPO2
R2023 T2965 T2962 punct ),al.
R2024 T2966 T2927 punct .,initiates
R2025 T2967 T2968 compound High,expression
R2026 T2968 T2975 nsubj expression,contributes
R2027 T2846 T2847 nsubj gene,participates
R2028 T2969 T2968 prep of,expression
R2029 T2970 T2969 pobj MGMT,of
R2030 T2971 T2970 cc or,MGMT
R2031 T2847 T2847 ROOT participates,participates
R2032 T2972 T2968 conj loss,expression
R2033 T2973 T2972 prep of,loss
R2034 T2974 T2973 pobj MMR,of
R2035 T2848 T2847 prep in,participates
R2036 T2975 T2999 ccomp contributes,al.
R2037 T2976 T2975 advmod significantly,contributes
R2038 T2977 T2975 prep to,contributes
R2039 T2849 T2852 det the,apoptosis
R2040 T2978 T2979 compound TMZ,resistance
R2041 T2979 T2977 pobj resistance,to
R2042 T2980 T2975 prep in,contributes
R2043 T2850 T2852 amod O6-methylguanine,apoptosis
R2044 T2981 T2983 amod many,cases
R2045 T2982 T2983 amod clinical,cases
R2046 T2851 T2852 amod lesion-induced,apoptosis
R2047 T2983 T2980 pobj cases,in
R2048 T2984 T2987 punct (,al.
R2049 T2985 T2987 compound Pollack,al.
R2050 T2852 T2848 pobj apoptosis,in
R2051 T2986 T2987 nmod et,al.
R2052 T2853 T2856 punct (,al.
R2053 T2854 T2856 nmod Fujikane,al.
R2054 T2987 T2975 advcl al.,contributes
R2055 T2988 T2987 punct ",",al.
R2056 T2855 T2856 nmod et,al.
R2057 T2989 T2987 npadvmod 2006,al.
R2058 T2990 T2999 punct ;,al.
R2059 T2991 T2993 compound Hegi,al.
R2060 T2992 T2993 nmod et,al.
R2061 T2856 T2852 appos al.,apoptosis
R2062 T2993 T2999 ccomp al.,al.
R2063 T2994 T2993 punct ",",al.
R2064 T2857 T2856 punct ",",al.
R2065 T2995 T2993 npadvmod 2008,al.
R2066 T2858 T2856 npadvmod 2012,al.
R2067 T2996 T2999 punct ;,al.
R2068 T2997 T2999 compound Sarkaria,al.
R2069 T2998 T2999 nmod et,al.
R2070 T2859 T2856 punct ),al.
R2071 T2999 T2999 ROOT al.,al.
R2072 T3000 T2999 punct ",",al.
R2073 T3001 T2999 npadvmod 2008,al.
R2074 T2860 T2847 punct .,participates
R2075 T3002 T2999 punct ),al.
R2076 T3003 T2999 punct .,al.
R2077 T3004 T3005 det The,initiation
R2078 T3005 T3009 nsubj initiation,fails
R2079 T3055 T3057 compound MGMT,expression
R2080 T3006 T3005 prep of,initiation
R2081 T3007 T3008 amod apoptotic,signaling
R2082 T3008 T3006 pobj signaling,of
R2083 T3009 T3009 ROOT fails,fails
R2084 T3010 T3009 prep in,fails
R2085 T3056 T3057 compound protein,expression
R2086 T3011 T3012 det the,absence
R2087 T3012 T3010 pobj absence,in
R2088 T3013 T3012 prep of,absence
R2089 T3057 T3054 dobj expression,blocks
R2090 T3014 T3016 det the,system
R2091 T3015 T3016 compound MMR,system
R2092 T3016 T3013 pobj system,of
R2093 T3058 T3059 punct ",",prolongs
R2094 T3017 T3009 punct .,fails
R2095 T3018 T3023 nsubjpass Sensitivity,associated
R2096 T3019 T3018 prep to,Sensitivity
R2097 T3059 T3059 ROOT prolongs,prolongs
R2098 T3020 T3019 pobj TMZ,to
R2099 T3060 T3062 compound cancer,survival
R2100 T3061 T3062 compound patient,survival
R2101 T3021 T3023 auxpass is,associated
R2102 T3022 T3023 advmod significantly,associated
R2103 T3062 T3059 dobj survival,prolongs
R2104 T3023 T3023 ROOT associated,associated
R2105 T3024 T3023 prep with,associated
R2106 T3025 T3027 det the,status
R2107 T3026 T3027 amod methylation,status
R2108 T3027 T3024 pobj status,with
R2109 T3028 T3027 prep of,status
R2110 T3063 T3059 punct .,prolongs
R2111 T3029 T3031 compound MGMT,promoter
R2112 T3030 T3031 compound gene,promoter
R2113 T3031 T3028 pobj promoter,of
R2114 T3064 T3068 advmod Intriguingly,reduces
R2115 T3032 T3027 prep in,status
R2116 T3033 T3032 pobj cells,in
R2117 T3065 T3068 punct ",",reduces
R2118 T3034 T3033 acl committed,cells
R2119 T3035 T3034 prep to,committed
R2120 T3036 T3035 pobj differentiation,to
R2121 T3066 T3067 amod overexpressed,microRNA-21
R2122 T3037 T3040 punct (,al.
R2123 T3038 T3040 compound Villalva,al.
R2124 T3039 T3040 nmod et,al.
R2125 T3067 T3068 nsubj microRNA-21,reduces
R2126 T3040 T3027 appos al.,status
R2127 T3041 T3040 punct ",",al.
R2128 T3042 T3040 npadvmod 2012,al.
R2129 T3068 T3068 ROOT reduces,reduces
R2130 T3043 T3023 punct ),associated
R2131 T3044 T3023 punct .,associated
R2132 T3045 T3046 det An,increase
R2133 T3069 T3071 nmod Bax/Bcl,ratio
R2134 T3046 T3059 nsubj increase,prolongs
R2135 T3047 T3046 prep in,increase
R2136 T3048 T3051 compound MGMT,methylation
R2137 T3070 T3069 nummod -2,Bax/Bcl
R2138 T3049 T3050 compound gene,promoter
R2139 T3050 T3051 compound promoter,methylation
R2140 T3051 T3047 pobj methylation,in
R2141 T3071 T3068 dobj ratio,reduces
R2142 T3052 T3051 punct ",",methylation
R2143 T3053 T3054 nsubj which,blocks
R2144 T3054 T3051 relcl blocks,methylation
R2145 T3072 T3071 cc and,ratio
R2146 T3073 T3074 amod caspase-3,activity
R2147 T3074 T3071 conj activity,ratio
R2148 T3152 T3149 pobj target,as
R2149 T3153 T3152 prep for,target
R2150 T3075 T3068 punct ",",reduces
R2151 T3154 T3156 amod high-grade,tumors
R2152 T3155 T3156 compound brain,tumors
R2153 T3076 T3077 advmod thereby,blocking
R2154 T3156 T3153 pobj tumors,for
R2155 T3157 T3148 punct .,considered
R2156 T3158 T3162 det The,enzyme
R2157 T3159 T3162 amod base,enzyme
R2158 T3160 T3162 compound excision,enzyme
R2159 T3161 T3162 compound repair,enzyme
R2160 T3162 T3178 nsubj enzyme,participates
R2161 T3077 T3068 advcl blocking,reduces
R2162 T3163 T3162 amod alkylpurine-DNA-N-glycosylase,enzyme
R2163 T3164 T3165 punct (,APNG
R2164 T3165 T3163 appos APNG,alkylpurine-DNA-N-glycosylase
R2165 T3078 T3079 amod TMZ-induced,apoptosis
R2166 T3166 T3165 punct ),APNG
R2167 T3167 T3163 punct ",",alkylpurine-DNA-N-glycosylase
R2168 T3079 T3077 dobj apoptosis,blocking
R2169 T3168 T3169 nsubj which,repairs
R2170 T3080 T3083 punct (,al.
R2171 T3169 T3163 relcl repairs,alkylpurine-DNA-N-glycosylase
R2172 T3170 T3172 det the,lesions
R2173 T3081 T3083 compound Shi,al.
R2174 T3171 T3172 amod cytotoxic,lesions
R2175 T3172 T3169 dobj lesions,repairs
R2176 T3173 T3169 advmod N3-methyladenine,repairs
R2177 T3082 T3083 nmod et,al.
R2178 T3174 T3173 cc and,N3-methyladenine
R2179 T3083 T3083 ROOT al.,al.
R2180 T3175 T3173 conj N7-methylguanine,N3-methyladenine
R2181 T3176 T3178 punct ",",participates
R2182 T3084 T3083 punct ",",al.
R2183 T3177 T3178 advmod also,participates
R2184 T3178 T3178 ROOT participates,participates
R2185 T3179 T3178 prep in,participates
R2186 T3085 T3083 npadvmod 2010,al.
R2187 T3180 T3182 det the,resistance
R2188 T3181 T3182 compound TMZ,resistance
R2189 T3182 T3179 pobj resistance,in
R2190 T3086 T3083 punct ),al.
R2191 T3183 T3186 punct (,al.
R2192 T3184 T3186 nmod Agnihotri,al.
R2193 T3185 T3186 nmod et,al.
R2194 T3087 T3083 punct .,al.
R2195 T3186 T3178 dep al.,participates
R2196 T3187 T3186 punct ",",al.
R2197 T3188 T3186 npadvmod 2012,al.
R2198 T3088 T3090 nsubjpass MicroRNA-21,considered
R2199 T3189 T3186 punct ),al.
R2200 T3190 T3178 punct .,participates
R2201 T3191 T3191 ROOT Upregulation,Upregulation
R2202 T3089 T3090 auxpass is,considered
R2203 T3192 T3191 prep of,Upregulation
R2204 T3193 T3196 amod mitochondrial,coupling
R2205 T3090 T3090 ROOT considered,considered
R2206 T3194 T3195 amod respiratory,chain
R2207 T3195 T3196 compound chain,coupling
R2208 T3196 T3192 pobj coupling,of
R2209 T3091 T3090 prep as,considered
R2210 T3092 T3094 det a,factor
R2211 T3197 T3198 aux to,suppress
R2212 T3198 T3191 advcl suppress,Upregulation
R2213 T3093 T3094 amod pro-survival,factor
R2214 T3199 T3200 det the,production
R2215 T3200 T3198 dobj production,suppress
R2216 T3094 T3091 pobj factor,as
R2217 T3201 T3200 prep of,production
R2218 T3202 T3204 amod reactive,species
R2219 T3203 T3204 compound oxygen,species
R2220 T3095 T3094 prep for,factor
R2221 T3204 T3201 pobj species,of
R2222 T3205 T3208 punct (,regulated
R2223 T3206 T3208 dep ROS,regulated
R2224 T3096 T3097 compound cancer,cells
R2225 T3207 T3208 punct ),regulated
R2226 T3097 T3095 pobj cells,for
R2227 T3208 T3198 advcl regulated,suppress
R2228 T3098 T3101 punct (,al.
R2229 T3209 T3208 agent by,regulated
R2230 T3210 T3212 compound cytochrome,oxidase
R2231 T3211 T3212 compound c,oxidase
R2232 T3099 T3101 compound Li,al.
R2233 T3212 T3209 pobj oxidase,by
R2234 T3213 T3208 punct contributes,regulated
R2235 T3100 T3101 nmod et,al.
R2236 T3214 T3213 prep in,contributes
R2237 T3215 T3214 pobj part,in
R2238 T3216 T3215 prep to,part
R2239 T3101 T3094 appos al.,factor
R2240 T3217 T3218 compound TMZ,resistance
R2241 T3218 T3216 pobj resistance,to
R2242 T3219 T3218 prep in,resistance
R2243 T3102 T3101 punct ",",al.
R2244 T3220 T3219 pobj gliomas,in
R2245 T3221 T3224 punct (,al.
R2246 T3222 T3224 compound Oliva,al.
R2247 T3103 T3101 npadvmod 2012,al.
R2248 T3223 T3224 nmod et,al.
R2249 T3224 T3208 dep al.,regulated
R2250 T3104 T3101 punct ),al.
R2251 T3225 T3224 punct ",",al.
R2252 T3226 T3224 npadvmod 2011,al.
R2253 T3227 T3224 punct ),al.
R2254 T3105 T3090 punct .,considered
R2255 T3228 T3191 punct .,Upregulation
R2256 T3229 T3235 nsubjpass Reversal,achieved
R2257 T3230 T3229 prep of,Reversal
R2258 T3231 T3230 pobj TMZ,of
R2259 T3232 T3235 nsubjpass resistance,achieved
R2260 T3233 T3235 aux may,achieved
R2261 T3106 T3107 nsubj Integrins,play
R2262 T3234 T3235 auxpass be,achieved
R2263 T3235 T3235 ROOT achieved,achieved
R2264 T3236 T3235 agent by,achieved
R2265 T3107 T3107 ROOT play,play
R2266 T3237 T3238 compound MGMT,pseudosubstrates
R2267 T3238 T3236 pobj pseudosubstrates,by
R2268 T3239 T3238 punct ",",pseudosubstrates
R2269 T3108 T3109 det a,role
R2270 T3240 T3238 conj O6-benzylguanine,pseudosubstrates
R2271 T3241 T3240 cc and,O6-benzylguanine
R2272 T3109 T3107 dobj role,play
R2273 T3242 T3240 conj lomeguatrib,O6-benzylguanine
R2274 T3243 T3244 aux to,sensitize
R2275 T3244 T3235 xcomp sensitize,achieved
R2276 T3245 T3244 dobj tumors,sensitize
R2277 T3110 T3109 prep in,role
R2278 T3246 T3244 prep to,sensitize
R2279 T3111 T3112 det the,resistance
R2280 T3247 T3246 pobj TMZ,to
R2281 T3112 T3110 pobj resistance,in
R2282 T3113 T3112 prep of,resistance
R2283 T3248 T3251 punct (,al.
R2284 T3114 T3115 amod advanced,cancers
R2285 T3115 T3113 pobj cancers,of
R2286 T3249 T3251 compound Zhang,al.
R2287 T3250 T3251 nmod et,al.
R2288 T3116 T3117 aux to,radiotherapy
R2289 T3251 T3246 parataxis al.,to
R2290 T3252 T3251 punct ",",al.
R2291 T3253 T3251 amod 2012b,al.
R2292 T3117 T3115 relcl radiotherapy,cancers
R2293 T3254 T3251 punct ),al.
R2294 T3255 T3235 punct .,achieved
R2295 T3118 T3117 cc and,radiotherapy
R2296 T3119 T3117 conj chemotherapy,radiotherapy
R2297 T3256 T3261 nsubj Methoxyamine-blocker,contributes
R2298 T3120 T3107 punct .,play
R2299 T3257 T3256 prep of,Methoxyamine-blocker
R2300 T3258 T3260 compound base,repair
R2301 T3259 T3260 compound excision,repair
R2302 T3121 T3122 amod α5β1,integrin
R2303 T3260 T3257 pobj repair,of
R2304 T3261 T3261 ROOT contributes,contributes
R2305 T3262 T3261 advmod significantly,contributes
R2306 T3122 T3124 nsubj integrin,regulates
R2307 T3263 T3261 prep to,contributes
R2308 T3264 T3265 compound TMZ,cytotoxicity
R2309 T3265 T3263 pobj cytotoxicity,to
R2310 T3266 T3271 advmod particularly,repaired
R2311 T3267 T3271 advmod when,repaired
R2312 T3268 T3269 amod O6-methylguanine,adducts
R2313 T3123 T3124 advmod negatively,regulates
R2314 T3269 T3271 nsubjpass adducts,repaired
R2315 T3270 T3271 auxpass are,repaired
R2316 T3271 T3261 advcl repaired,contributes
R2317 T3124 T3124 ROOT regulates,regulates
R2318 T3272 T3271 cc or,repaired
R2319 T3273 T3271 conj tolerated,repaired
R2320 T3274 T3283 punct (,al.
R2321 T3275 T3277 nmod Goellner,al.
R2322 T3125 T3124 dobj p53,regulates
R2323 T3276 T3277 nmod et,al.
R2324 T3277 T3283 ccomp al.,al.
R2325 T3126 T3125 acl signaling,p53
R2326 T3278 T3277 punct ",",al.
R2327 T3279 T3277 npadvmod 2011,al.
R2328 T3280 T3283 punct ;,al.
R2329 T3127 T3124 punct ",",regulates
R2330 T3281 T3283 compound Zhang,al.
R2331 T3282 T3283 nmod et,al.
R2332 T3283 T3283 ROOT al.,al.
R2333 T3128 T3124 cc and,regulates
R2334 T3284 T3285 punct ",",2012b
R2335 T3285 T3283 amod 2012b,al.
R2336 T3286 T3285 punct ),2012b
R2337 T3129 T3130 det the,event
R2338 T3287 T3261 punct .,contributes
R2339 T3130 T3131 nsubj event,induces
R2340 T3288 T3289 amod Dual,targeting
R2341 T3131 T3124 conj induces,regulates
R2342 T3132 T3134 amod glioma,resistance
R2343 T3289 T3301 nsubj targeting,reverse
R2344 T3290 T3289 prep of,targeting
R2345 T3291 T3293 compound base,repair
R2346 T3133 T3134 compound cell,resistance
R2347 T3292 T3293 compound excision,repair
R2348 T3293 T3290 pobj repair,of
R2349 T3134 T3131 dobj resistance,induces
R2350 T3294 T3293 cc and,repair
R2351 T3295 T3299 nmod NAD,biosynthesis
R2352 T3296 T3297 punct (,+
R2353 T3135 T3134 prep to,resistance
R2354 T3297 T3295 parataxis +,NAD
R2355 T3298 T3299 punct ),biosynthesis
R2356 T3299 T3293 conj biosynthesis,repair
R2357 T3300 T3301 aux may,reverse
R2358 T3136 T3135 pobj TMZ,to
R2359 T3301 T3301 ROOT reverse,reverse
R2360 T3302 T3303 compound TMZ,resistance
R2361 T3303 T3301 dobj resistance,reverse
R2362 T3304 T3301 prep in,reverse
R2363 T3305 T3304 pobj patients,in
R2364 T3306 T3305 prep with,patients
R2365 T3137 T3140 punct (,al.
R2366 T3307 T3310 amod resistant,GBM
R2367 T3308 T3307 cc and,resistant
R2368 T3309 T3307 conj recurrent,resistant
R2369 T3138 T3140 nmod Janouskova,al.
R2370 T3310 T3306 pobj GBM,with
R2371 T3311 T3310 punct (,GBM
R2372 T3312 T3314 nmod Goellner,al.
R2373 T3139 T3140 nmod et,al.
R2374 T3313 T3314 nmod et,al.
R2375 T3314 T3301 dep al.,reverse
R2376 T3140 T3134 appos al.,resistance
R2377 T3141 T3140 punct ",",al.
R2378 T3315 T3314 punct ",",al.
R2379 T3142 T3140 npadvmod 2012,al.
R2380 T3316 T3314 npadvmod 2011,al.
R2381 T3317 T3314 punct ),al.
R2382 T3318 T3301 punct .,reverse
R2383 T3319 T3337 nsubj Interferon-β,increase
R2384 T3143 T3131 punct ),induces
R2385 T3320 T3321 punct (,IFN-β
R2386 T3321 T3319 appos IFN-β,Interferon-β
R2387 T3322 T3321 punct ),IFN-β
R2388 T3144 T3124 punct .,regulates
R2389 T3323 T3319 punct ",",Interferon-β
R2390 T3324 T3319 appos levetiracetam,Interferon-β
R2391 T3325 T3326 punct (,LEV
R2392 T3145 T3146 amod α5β1,integrin
R2393 T3326 T3324 appos LEV,levetiracetam
R2394 T3327 T3326 punct ),LEV
R2395 T3328 T3324 punct ",",levetiracetam
R2396 T3146 T3148 nsubjpass integrin,considered
R2397 T3329 T3324 conj resveratrol,levetiracetam
R2398 T3330 T3329 punct ",",resveratrol
R2399 T3331 T3329 cc and,resveratrol
R2400 T3147 T3148 auxpass is,considered
R2401 T3332 T3333 amod valproic,acid
R2402 T3333 T3329 conj acid,resveratrol
R2403 T3334 T3333 punct (,acid
R2404 T3335 T3337 nsubj VAP,increase
R2405 T3148 T3148 ROOT considered,considered
R2406 T3336 T3337 punct ),increase
R2407 T3337 T3337 ROOT increase,increase
R2408 T3149 T3148 prep as,considered
R2409 T3338 T3339 det the,sensitivity
R2410 T3339 T3337 dobj sensitivity,increase
R2411 T3340 T3339 prep of,sensitivity
R2412 T3341 T3340 pobj TMZ,of
R2413 T3342 T3337 prep through,increase
R2414 T3150 T3152 det a,target
R2415 T3343 T3342 pobj MGMT-dependent,through
R2416 T3344 T3343 cc or,MGMT-dependent
R2417 T3345 T3346 punct -,independent
R2418 T3151 T3152 amod therapeutic,target
R2419 T3443 T3442 prep in,failure
R2420 T3346 T3347 amod independent,mechanisms
R2421 T3347 T3343 conj mechanisms,MGMT-dependent
R2422 T3348 T3347 punct (,mechanisms
R2423 T3444 T3445 compound TMZ,treatment
R2424 T3349 T3351 compound Nakada,al.
R2425 T3350 T3351 nmod et,al.
R2426 T3351 T3347 appos al.,mechanisms
R2427 T3445 T3443 pobj treatment,in
R2428 T3352 T3351 punct ",",al.
R2429 T3353 T3351 npadvmod 2012,al.
R2430 T3446 T3437 punct .,are
R2431 T3354 T3347 punct ),mechanisms
R2432 T3447 T3448 det The,concept
R2433 T3355 T3337 punct .,increase
R2434 T3356 T3362 nsubj Resveratrol,reverses
R2435 T3357 T3356 punct ",",Resveratrol
R2436 T3448 T3478 nsubjpass concept,al.
R2437 T3358 T3360 det a,polyphenol
R2438 T3359 T3360 amod natural,polyphenol
R2439 T3360 T3356 appos polyphenol,Resveratrol
R2440 T3361 T3356 punct ",",Resveratrol
R2441 T3449 T3448 prep of,concept
R2442 T3362 T3362 ROOT reverses,reverses
R2443 T3363 T3364 compound TMZ,resistance
R2444 T3450 T3452 compound cancer,cell
R2445 T3364 T3362 dobj resistance,reverses
R2446 T3365 T3362 prep via,reverses
R2447 T3366 T3368 det an,mechanism
R2448 T3451 T3452 compound stem,cell
R2449 T3367 T3368 amod NF-κB-dependent,mechanism
R2450 T3368 T3365 pobj mechanism,via
R2451 T3369 T3368 punct (,mechanism
R2452 T3452 T3453 compound cell,survival
R2453 T3370 T3372 compound Huang,al.
R2454 T3371 T3372 nmod et,al.
R2455 T3453 T3449 pobj survival,of
R2456 T3372 T3368 appos al.,mechanism
R2457 T3373 T3372 punct ",",al.
R2458 T3374 T3372 npadvmod 2012,al.
R2459 T3454 T3448 prep from,concept
R2460 T3375 T3368 punct ),mechanism
R2461 T3376 T3362 punct .,reverses
R2462 T3377 T3378 nummod STAT3,inhibitor
R2463 T3378 T3384 nmod inhibitor,efficacy
R2464 T3379 T3378 cc or,inhibitor
R2465 T3380 T3382 nummod STAT3,potentiates
R2466 T3381 T3382 amod knockdown,potentiates
R2467 T3455 T3454 pobj treatment,from
R2468 T3382 T3378 conj potentiates,inhibitor
R2469 T3383 T3384 compound TMZ,efficacy
R2470 T3384 T3384 ROOT efficacy,efficacy
R2471 T3456 T3448 prep with,concept
R2472 T3385 T3384 prep in,efficacy
R2473 T3386 T3389 amod resistant,lines
R2474 T3457 T3456 pobj TMZ,with
R2475 T3387 T3389 nmod GBM,lines
R2476 T3388 T3389 compound cell,lines
R2477 T3389 T3385 pobj lines,in
R2478 T3458 T3457 cc and,TMZ
R2479 T3390 T3389 punct (,lines
R2480 T3391 T3393 compound Kohsaka,al.
R2481 T3392 T3393 nmod et,al.
R2482 T3459 T3461 amod other,drugs
R2483 T3393 T3389 appos al.,lines
R2484 T3460 T3461 amod chemotherapeutic,drugs
R2485 T3394 T3393 punct ",",al.
R2486 T3461 T3457 conj drugs,TMZ
R2487 T3395 T3393 npadvmod 2012,al.
R2488 T3396 T3389 punct ),lines
R2489 T3462 T3463 aux has,been
R2490 T3397 T3384 punct .,efficacy
R2491 T3398 T3399 compound Intratumoral,hypoxia
R2492 T3399 T3400 nsubj hypoxia,is
R2493 T3463 T3478 auxpass been,al.
R2494 T3400 T3400 ROOT is,is
R2495 T3401 T3400 acomp common,is
R2496 T3464 T3465 advmod more,complicated
R2497 T3402 T3400 prep in,is
R2498 T3403 T3402 pobj GBMs,in
R2499 T3465 T3478 ccomp complicated,al.
R2500 T3404 T3400 cc and,is
R2501 T3405 T3407 aux may,associated
R2502 T3406 T3407 auxpass be,associated
R2503 T3466 T3468 mark than,thought
R2504 T3407 T3400 conj associated,is
R2505 T3408 T3407 prep with,associated
R2506 T3409 T3410 det the,development
R2507 T3467 T3468 advmod previously,thought
R2508 T3410 T3408 pobj development,with
R2509 T3411 T3410 prep of,development
R2510 T3412 T3413 compound TMZ,resistance
R2511 T3413 T3411 pobj resistance,of
R2512 T3414 T3400 punct .,is
R2513 T3415 T3416 amod Induced,hyperoxia
R2514 T3468 T3465 advcl thought,complicated
R2515 T3416 T3419 nsubjpass hyperoxia,utilized
R2516 T3417 T3419 aux can,utilized
R2517 T3418 T3419 auxpass be,utilized
R2518 T3419 T3419 ROOT utilized,utilized
R2519 T3469 T3465 punct (,complicated
R2520 T3420 T3421 aux to,reverse
R2521 T3421 T3419 xcomp reverse,utilized
R2522 T3422 T3423 compound TMZ,resistance
R2523 T3470 T3472 nmod Beier,al.
R2524 T3423 T3421 dobj resistance,reverse
R2525 T3424 T3421 prep in,reverse
R2526 T3425 T3424 pobj GBMs,in
R2527 T3471 T3472 nmod et,al.
R2528 T3472 T3465 punct al.,complicated
R2529 T3426 T3429 punct (,al.
R2530 T3473 T3472 punct ",",al.
R2531 T3427 T3429 nmod Sun,al.
R2532 T3428 T3429 nmod et,al.
R2533 T3429 T3419 parataxis al.,utilized
R2534 T3474 T3472 npadvmod 2011,al.
R2535 T3430 T3429 punct ",",al.
R2536 T3431 T3429 npadvmod 2012,al.
R2537 T3475 T3478 punct ;,al.
R2538 T3432 T3429 punct ),al.
R2539 T3433 T3419 punct .,utilized
R2540 T3434 T3436 compound Cancer,cells
R2541 T3476 T3478 compound Chen,al.
R2542 T3435 T3436 compound stem,cells
R2543 T3436 T3437 nsubj cells,are
R2544 T3437 T3437 ROOT are,are
R2545 T3477 T3478 compound et,al.
R2546 T3478 T3478 ROOT al.,al.
R2547 T3479 T3478 punct ",",al.
R2548 T3438 T3437 advmod probably,are
R2549 T3439 T3440 det the,key
R2550 T3480 T3478 npadvmod 2012,al.
R2551 T3440 T3437 attr key,are
R2552 T3441 T3440 prep to,key
R2553 T3481 T3478 punct ),al.
R2554 T3442 T3441 pobj failure,to
R2555 T3482 T3478 punct .,al.
R2556 T3483 T3486 amod CD133-positive,cells
R2557 T3484 T3485 compound cancer,stem
R2558 T3485 T3486 compound stem,cells
R2559 T3488 T3488 ROOT expressed,expressed
R2560 T3489 T3488 prep in,expressed
R2561 T3490 T3493 det both,cells
R2562 T3491 T3493 amod normal,cells
R2563 T3486 T3488 nsubjpass cells,expressed
R2564 T3492 T3493 compound stem,cells
R2565 T3493 T3489 pobj cells,in
R2566 T3494 T3493 cc and,cells
R2567 T3495 T3496 compound cancer,stem
R2568 T3487 T3488 auxpass are,expressed
R2569 T3496 T3497 compound stem,cells
R2570 T3497 T3493 conj cells,cells
R2571 T3498 T3488 punct (,expressed
R2572 T3499 T3488 dep Donovan,expressed
R2573 T3500 T3499 cc and,Donovan
R2574 T3501 T3499 conj Pilkington,Donovan
R2575 T3502 T3501 punct ",",Pilkington
R2576 T3503 T3501 npadvmod 2012,Pilkington
R2577 T3504 T3501 punct ),Pilkington
R2578 T3505 T3488 punct .,expressed
R2579 T3506 T3529 advmod However,established
R2580 T3507 T3529 punct ",",established
R2581 T3508 T3509 det the,role
R2582 T3509 T3529 nsubjpass role,established
R2583 T3510 T3509 prep of,role
R2584 T3511 T3510 pobj CD133,of
R2585 T3512 T3509 prep as,role
R2586 T3513 T3514 det a,marker
R2587 T3514 T3512 pobj marker,as
R2588 T3515 T3514 prep for,marker
R2589 T3516 T3519 amod glioma,cells
R2590 T3517 T3518 compound cancer,stem
R2591 T3518 T3519 compound stem,cells
R2592 T3519 T3515 pobj cells,for
R2593 T3520 T3519 amod relative,cells
R2594 T3521 T3520 prep to,relative
R2595 T3522 T3524 poss its,function
R2596 T3523 T3524 amod biological,function
R2597 T3524 T3521 pobj function,to
R2598 T3525 T3529 aux has,established
R2599 T3526 T3529 advmod yet,established
R2600 T3527 T3529 aux to,established
R2601 T3528 T3529 auxpass be,established
R2602 T3529 T3529 ROOT established,established
R2603 T3530 T3529 punct .,established
R3890 T5791 T5790 punct ",",al.
R3894 T5771 T5779 advmod Recently,shown
R3895 T5772 T5779 punct ",",shown
R3896 T5773 T5775 nmod tumor,p53
R3897 T5774 T5775 compound suppressors,p53
R3898 T5775 T5779 nsubjpass p53,shown
R3899 T5776 T5775 cc and,p53
R3900 T5777 T5775 conj WWOX,p53
R3901 T5792 T5790 npadvmod 2012,al.
R3902 T5778 T5779 auxpass were,shown
R3903 T5779 T5779 ROOT shown,shown
R3904 T5780 T5781 aux to,regulate
R3905 T5793 T5783 punct ),apoptosis
R3906 T5781 T5779 xcomp regulate,shown
R3907 T5782 T5783 det the,apoptosis
R3908 T5783 T5781 dobj apoptosis,regulate
R3909 T5794 T5779 punct .,shown
R3910 T5784 T5783 prep of,apoptosis
R3911 T5785 T5786 compound glioblastoma,cells
R3912 T5786 T5784 pobj cells,of
R3913 T5787 T5790 punct (,al.
R3914 T5795 T5797 nmod WW,oxidoreductase
R3915 T5788 T5790 compound Chiang,al.
R3916 T5789 T5790 nmod et,al.
R3917 T5790 T5783 appos al.,apoptosis
R3918 T5796 T5797 amod domain-containing,oxidoreductase
R3919 T5797 T5809 nsubjpass oxidoreductase,encoded
R3920 T5798 T5797 punct ",",oxidoreductase
R3921 T5835 T5834 appos FRA16D,site
R3922 T5799 T5797 acl known,oxidoreductase
R3923 T5836 T5820 punct .,located
R3924 T5837 T5840 det The,protein
R3925 T5800 T5799 prep as,known
R3926 T5838 T5840 amod full-length,protein
R3927 T5839 T5840 compound WWOX,protein
R3928 T5840 T5842 nsubjpass protein,composed
R3929 T5801 T5800 pobj WWOX,as
R3930 T5841 T5842 auxpass is,composed
R3931 T5842 T5842 ROOT composed,composed
R3932 T5843 T5842 prep of,composed
R3933 T5802 T5809 punct ",",encoded
R3934 T5844 T5847 nummod two,domains
R3935 T5845 T5847 amod N-terminal,domains
R3936 T5846 T5847 compound WW,domains
R3937 T5803 T5809 prep FOR,encoded
R3938 T5847 T5843 pobj domains,of
R3939 T5848 T5847 punct ",",domains
R3940 T5849 T5853 det a,dehydrogenase/reductase
R3941 T5804 T5803 punct ",",FOR
R3942 T5850 T5853 amod C-terminal,dehydrogenase/reductase
R3943 T5805 T5803 cc or,FOR
R3944 T5851 T5853 compound short-chain,dehydrogenase/reductase
R3945 T5852 T5853 compound alcohol,dehydrogenase/reductase
R3946 T5853 T5847 appos dehydrogenase/reductase,domains
R3947 T5854 T5855 punct (,SDR
R3948 T5806 T5809 nsubjpass WOX1,encoded
R3949 T5855 T5853 appos SDR,dehydrogenase/reductase
R3950 T5856 T5855 punct ),SDR
R3951 T5857 T5853 conj domain,dehydrogenase/reductase
R3952 T5807 T5809 punct ",",encoded
R3953 T5858 T5857 punct ",",domain
R3954 T5859 T5857 cc and,domain
R3955 T5860 T5864 det a,D3
R3956 T5808 T5809 auxpass is,encoded
R3957 T5861 T5864 amod proapoptotic,D3
R3958 T5862 T5863 amod C-terminal,tail
R3959 T5863 T5864 compound tail,D3
R3960 T5809 T5809 ROOT encoded,encoded
R3961 T5864 T5857 conj D3,domain
R3962 T5865 T5868 punct (,al.
R3963 T5866 T5868 compound Chang,al.
R3964 T5810 T5809 agent by,encoded
R3965 T5867 T5868 nmod et,al.
R3966 T5868 T5864 appos al.,D3
R3967 T5869 T5868 punct ",",al.
R3968 T5811 T5815 amod human,gene
R3969 T5870 T5868 appos 2001,al.
R3970 T5871 T5870 punct ",",2001
R3971 T5872 T5870 conj 2007,2001
R3972 T5812 T5811 cc or,human
R3973 T5873 T5872 punct ",",2007
R3974 T5874 T5872 conj 2010,2007
R3975 T5813 T5811 conj mouse,human
R3976 T5875 T5847 punct ;,domains
R3977 T5876 T5878 compound Aqeilan,al.
R3978 T5877 T5878 compound et,al.
R3979 T5814 T5815 compound WWOX/Wwox,gene
R3980 T5878 T5847 appos al.,domains
R3981 T5879 T5878 punct ",",al.
R3982 T5815 T5810 pobj gene,by
R3983 T5880 T5878 appos 2004,al.
R3984 T5881 T5880 punct ",",2004
R3985 T5882 T5880 conj 2007,2004
R3986 T5816 T5809 punct .,encoded
R3987 T5883 T5847 punct ;,domains
R3988 T5884 T5886 compound Hong,al.
R3989 T5817 T5818 det This,gene
R3990 T5885 T5886 nmod et,al.
R3991 T5886 T5847 appos al.,domains
R3992 T5887 T5886 punct ",",al.
R3993 T5818 T5820 nsubjpass gene,located
R3994 T5888 T5886 npadvmod 2007,al.
R3995 T5889 T5847 punct ;,domains
R3996 T5890 T5892 compound Salah,al.
R3997 T5819 T5820 auxpass is,located
R3998 T5891 T5892 nmod et,al.
R3999 T5892 T5847 appos al.,domains
R4000 T5893 T5892 punct ",",al.
R4001 T5820 T5820 ROOT located,located
R4002 T5894 T5892 npadvmod 2012,al.
R4003 T5895 T5847 punct ),domains
R4004 T5821 T5820 prep in,located
R4005 T5896 T5847 punct (,domains
R4006 T5897 T5847 appos Figure,domains
R4007 T5898 T5897 nummod 1,Figure
R4008 T5822 T5821 pobj chromosome,in
R4009 T5899 T5847 punct ),domains
R4010 T5900 T5842 punct .,composed
R4011 T5901 T5903 nsubj WWOX,act
R4012 T5823 T5822 nummod 16q23,chromosome
R4013 T5902 T5903 aux may,act
R4014 T5903 T5937 ccomp act,al.
R4015 T5904 T5903 prep as,act
R4016 T5905 T5907 det an,receptor
R4017 T5824 T5822 nummod .3,chromosome
R4018 T5906 T5907 amod alternative,receptor
R4019 T5907 T5904 pobj receptor,as
R4020 T5825 T5820 npadvmod 24.1,located
R4021 T5908 T5907 prep for,receptor
R4022 T5909 T5911 compound sex,hormones
R4023 T5910 T5911 compound steroid,hormones
R4024 T5911 T5908 pobj hormones,for
R4025 T5912 T5903 punct ",",act
R4026 T5913 T5917 mark since,possesses
R4027 T5826 T5825 punct ",",24.1
R4028 T5914 T5916 poss its,domain
R4029 T5915 T5916 compound SDR,domain
R4030 T5916 T5917 nsubj domain,possesses
R4031 T5827 T5828 det an,area
R4032 T5917 T5903 advcl possesses,act
R4033 T5918 T5920 det an,motif
R4034 T5919 T5920 compound NSYK,motif
R4035 T5828 T5825 npadvmod area,24.1
R4036 T5920 T5917 dobj motif,possesses
R4037 T5921 T5920 amod capable,motif
R4038 T5922 T5921 prep of,capable
R4039 T5829 T5828 acl known,area
R4040 T5923 T5922 pcomp interacting,of
R4041 T5924 T5923 prep with,interacting
R4042 T5925 T5924 pobj androgen,with
R4043 T5830 T5829 prep as,known
R4044 T5926 T5925 cc and,androgen
R4045 T5927 T5925 conj estrogen,androgen
R4046 T5928 T5931 punct (,al.
R4047 T5831 T5834 det the,site
R4048 T5929 T5931 compound Chang,al.
R4049 T5930 T5931 nmod et,al.
R4050 T5931 T5921 appos al.,capable
R4051 T5832 T5834 amod common,site
R4052 T5833 T5834 amod fragile,site
R4053 T5834 T5830 pobj site,as
R4054 T6029 T6033 nsubj Restoration,prevents
R4055 T5932 T5933 punct ",",2005a
R4056 T5933 T5931 amod 2005a,al.
R4057 T6030 T6029 prep of,Restoration
R4058 T5934 T5937 punct ;,al.
R4059 T5935 T5937 compound Su,al.
R4060 T5936 T5937 nmod et,al.
R4061 T6031 T6032 compound WWOX,gene
R4062 T5937 T5937 ROOT al.,al.
R4063 T6032 T6030 pobj gene,of
R4064 T5938 T5937 punct ",",al.
R4065 T6033 T6033 ROOT prevents,prevents
R4066 T5939 T5937 npadvmod 2012,al.
R4067 T6034 T6035 det the,growth
R4068 T5940 T5937 punct ),al.
R4069 T5941 T5937 punct .,al.
R4070 T5942 T5947 nsubjpass Expression,altered
R4071 T6035 T6033 dobj growth,prevents
R4072 T5943 T5942 prep of,Expression
R4073 T5944 T5943 pobj WWOX,of
R4074 T5945 T5947 auxpass is,altered
R4075 T5946 T5947 preconj either,altered
R4076 T5947 T6013 ccomp altered,al.
R4077 T5948 T5947 cc or,altered
R4078 T6036 T6035 prep of,growth
R4079 T5949 T5947 conj lost,altered
R4080 T6037 T6038 compound lung,cancer
R4081 T5950 T5949 prep from,lost
R4082 T6038 T6036 pobj cancer,of
R4083 T6039 T6042 punct (,al.
R4084 T5951 T5952 amod epigenetic,modification
R4085 T6040 T6042 compound Fabbri,al.
R4086 T6041 T6042 nmod et,al.
R4087 T5952 T5950 pobj modification,from
R4088 T6042 T6035 appos al.,growth
R4089 T6043 T6042 punct ",",al.
R4090 T5953 T5952 prep in,modification
R4091 T6044 T6042 npadvmod 2005,al.
R4092 T5954 T5956 amod multiple,cancers
R4093 T6045 T6035 punct ),growth
R4094 T6046 T6035 punct ",",growth
R4095 T6047 T6048 compound pancreatic,cancer
R4096 T6048 T6035 appos cancer,growth
R4097 T5955 T5956 amod malignant,cancers
R4098 T6049 T6052 punct (,al.
R4099 T5956 T5953 pobj cancers,in
R4100 T6050 T6052 compound Nakayama,al.
R4101 T6051 T6052 nmod et,al.
R4102 T5957 T5956 punct ",",cancers
R4103 T5958 T5959 amod such,as
R4104 T6052 T6035 appos al.,growth
R4105 T5959 T5956 prep as,cancers
R4106 T5960 T5963 amod non-small,carcinoma
R4107 T6053 T6052 punct ",",al.
R4108 T5961 T5962 compound cell,lung
R4109 T5962 T5963 compound lung,carcinoma
R4110 T5963 T5959 pobj carcinoma,as
R4111 T6054 T6052 npadvmod 2008,al.
R4112 T5964 T5967 punct (,al.
R4113 T5965 T5967 nmod Donati,al.
R4114 T6055 T6035 punct ),growth
R4115 T5966 T5967 nmod et,al.
R4116 T5967 T5963 advmod al.,carcinoma
R4117 T5968 T5967 punct ",",al.
R4118 T6056 T6033 punct ",",prevents
R4119 T5969 T5967 npadvmod 2007,al.
R4120 T5970 T5967 punct ),al.
R4121 T5971 T5963 punct ",",carcinoma
R4122 T5972 T5973 amod hematopoietic,malignancies
R4123 T5973 T5963 conj malignancies,carcinoma
R4124 T6057 T6033 cc and,prevents
R4125 T5974 T5963 punct (,carcinoma
R4126 T5975 T6003 poss Ishii,carcinoma
R4127 T5976 T5975 cc and,Ishii
R4128 T5977 T5975 conj Furukawa,Ishii
R4129 T6058 T6059 compound prostate,cancer
R4130 T5978 T5977 punct ",",Furukawa
R4131 T5979 T5977 npadvmod 2004,Furukawa
R4132 T5980 T5977 punct ),Furukawa
R4133 T6059 T6033 conj cancer,prevents
R4134 T5981 T5983 punct ",",carcinoma
R4135 T5982 T5983 amod gastric,carcinoma
R4136 T5983 T5975 conj carcinoma,Ishii
R4137 T6060 T6063 punct (,al.
R4138 T5984 T5983 punct (,carcinoma
R4139 T5985 T5987 amod Aqeilan,al.
R4140 T6061 T6063 nmod Hong,al.
R4141 T5986 T5987 nmod et,al.
R4142 T5987 T5983 appos al.,carcinoma
R4143 T5988 T5987 punct ",",al.
R4144 T6062 T6063 nmod et,al.
R4145 T5989 T5987 pobj 2004,al.
R4146 T5990 T5983 punct ),carcinoma
R4147 T5991 T5983 punct ",",carcinoma
R4148 T6063 T6059 parataxis al.,cancer
R4149 T5992 T5993 amod pancreatic,carcinoma
R4150 T5993 T5983 conj carcinoma,carcinoma
R4151 T5994 T5997 punct (,al.
R4152 T6064 T6063 punct ",",al.
R4153 T5995 T5997 nmod Kuroki,al.
R4154 T5996 T5997 nmod et,al.
R4155 T6065 T6063 npadvmod 2009,al.
R4156 T5997 T5983 appos al.,carcinoma
R4157 T5998 T5997 punct ",",al.
R4158 T5999 T5997 npadvmod 2004,al.
R4159 T6066 T6063 punct ),al.
R4160 T6000 T5983 punct ),carcinoma
R4161 T6001 T5983 punct ",",carcinoma
R4162 T6067 T6033 punct .,prevents
R4163 T6002 T6003 compound breast,carcinoma
R4164 T6003 T5963 appos carcinoma,carcinoma
R4165 T6004 T6007 punct (,al.
R4166 T6068 T6071 det The,domain
R4167 T6005 T6007 compound Guler,al.
R4168 T6006 T6007 nmod et,al.
R4169 T6007 T6003 appos al.,carcinoma
R4170 T6069 T6071 amod first,domain
R4171 T6008 T6007 punct ",",al.
R4172 T6009 T6007 npadvmod 2004,al.
R4173 T6010 T6013 punct ;,al.
R4174 T6011 T6013 compound Aqeilan,al.
R4175 T6012 T6013 compound et,al.
R4176 T6013 T6013 ROOT al.,al.
R4177 T6070 T6071 compound WW,domain
R4178 T6014 T6013 punct ",",al.
R4179 T6015 T6013 npadvmod 2007,al.
R4180 T6016 T6013 punct ),al.
R4181 T6071 T6075 nsubj domain,interact
R4182 T6017 T6013 punct ",",al.
R4183 T6018 T6013 cc and,al.
R4184 T6019 T6020 compound glioblastoma,multiforme
R4185 T6072 T6071 prep of,domain
R4186 T6020 T6013 conj multiforme,al.
R4187 T6021 T6020 punct (,multiforme
R4188 T6022 T6024 compound Kosla,al.
R4189 T6073 T6072 pobj WWOX,of
R4190 T6023 T6024 nmod et,al.
R4191 T6024 T6020 appos al.,multiforme
R4192 T6025 T6024 punct ",",al.
R4193 T6074 T6075 aux may,interact
R4194 T6026 T6024 npadvmod 2011,al.
R4195 T6027 T6020 punct ),multiforme
R4196 T6075 T6075 ROOT interact,interact
R4197 T6028 T6013 punct .,al.
R4198 T6076 T6075 prep with,interact
R4199 T6077 T6076 pobj proteins,with
R4200 T6078 T6077 acl possessing,proteins
R4201 T6079 T6081 det a,motif
R4202 T6126 T6089 punct .,p73
R4203 T6080 T6081 compound PPxY,motif
R4204 T6127 T6128 advmod Transiently,overexpressed
R4205 T6128 T6129 compound overexpressed,WWOX
R4206 T6081 T6078 dobj motif,possessing
R4207 T6129 T6130 nsubj WWOX,binds
R4208 T6130 T6130 ROOT binds,binds
R4209 T6082 T6081 punct (,motif
R4210 T6131 T6132 compound transcription,factors
R4211 T6132 T6130 dobj factors,binds
R4212 T6133 T6132 appos AP-2,factors
R4213 T6083 T6081 appos s,motif
R4214 T6134 T6133 punct ",",AP-2
R4215 T6084 T6081 punct ),motif
R4216 T6135 T6133 appos p73,AP-2
R4217 T6136 T6133 punct ",",AP-2
R4218 T6085 T6086 amod such,as
R4219 T6137 T6133 cc and,AP-2
R4220 T6138 T6133 conj c-Jun,AP-2
R4221 T6139 T6130 cc and,binds
R4222 T6140 T6130 conj block,binds
R4223 T6141 T6143 poss their,relocation
R4224 T6142 T6143 amod nuclear,relocation
R4225 T6086 T6078 prep as,possessing
R4226 T6143 T6140 dobj relocation,block
R4227 T6144 T6140 prep in,block
R4228 T6145 T6144 pobj vitro,in
R4229 T6087 T6086 pobj AP-2γ,as
R4230 T6146 T6145 punct ",",vitro
R4231 T6147 T6148 nsubj which,suppresses
R4232 T6148 T6145 relcl suppresses,vitro
R4233 T6088 T6087 punct ",",AP-2γ
R4234 T6149 T6150 compound cancer,cell
R4235 T6150 T6151 compound cell,survival
R4236 T6151 T6148 dobj survival,suppresses
R4237 T6089 T6087 conj p73,AP-2γ
R4238 T6152 T6155 punct (,al.
R4239 T6153 T6155 amod Salah,al.
R4240 T6090 T6089 punct ",",p73
R4241 T6154 T6155 nmod et,al.
R4242 T6155 T6148 npadvmod al.,suppresses
R4243 T6156 T6155 punct ",",al.
R4244 T6091 T6089 conj ErbB4,p73
R4245 T6157 T6155 npadvmod 2012,al.
R4246 T6158 T6155 punct ),al.
R4247 T6092 T6091 punct ",",ErbB4
R4248 T6159 T6130 punct .,binds
R4249 T6160 T6165 prep In,co-migrates
R4250 T6161 T6162 amod stark,contrast
R4251 T6093 T6091 conj Ezrin,ErbB4
R4252 T6162 T6160 pobj contrast,In
R4253 T6163 T6165 punct ",",co-migrates
R4254 T6164 T6165 nsubj Wwox,co-migrates
R4255 T6094 T6093 punct ",",Ezrin
R4256 T6165 T6165 ROOT co-migrates,co-migrates
R4257 T6166 T6165 prep with,co-migrates
R4258 T6167 T6171 amod proapoptotic,factors
R4259 T6095 T6093 conj SIMPLE,Ezrin
R4260 T6168 T6167 cc and,proapoptotic
R4261 T6169 T6167 conj pro-survival,proapoptotic
R4262 T6096 T6095 punct ",",SIMPLE
R4263 T6170 T6171 compound transcription,factors
R4264 T6171 T6166 pobj factors,with
R4265 T6172 T6165 prep to,co-migrates
R4266 T6173 T6174 det the,nuclei
R4267 T6097 T6095 conj c-Jun,SIMPLE
R4268 T6174 T6172 pobj nuclei,to
R4269 T6175 T6174 prep of,nuclei
R4270 T6098 T6097 punct ",",c-Jun
R4271 T6176 T6175 pobj neurons,of
R4272 T6177 T6174 prep upon,nuclei
R4273 T6178 T6180 amod sciatic,axotomy
R4274 T6099 T6097 conj RUNX4,c-Jun
R4275 T6100 T6099 punct ",",RUNX4
R4276 T6179 T6180 compound nerve,axotomy
R4277 T6101 T6089 cc and,p73
R4278 T6180 T6177 pobj axotomy,upon
R4279 T6181 T6180 prep in,axotomy
R4280 T6182 T6181 pobj rats,in
R4281 T6102 T6103 amod many,others
R4282 T6183 T6186 punct (,al.
R4283 T6184 T6186 compound Li,al.
R4284 T6185 T6186 nmod et,al.
R4285 T6103 T6089 conj others,p73
R4286 T6104 T6103 punct (,others
R4287 T6186 T6165 appos al.,co-migrates
R4288 T6105 T6107 compound Chang,al.
R4289 T6187 T6186 punct ",",al.
R4290 T6188 T6186 npadvmod 2009,al.
R4291 T6106 T6107 nmod et,al.
R4292 T6189 T6186 punct ),al.
R4293 T6190 T6165 punct .,co-migrates
R4294 T6107 T6103 appos al.,others
R4295 T6191 T6192 det No,blocking
R4296 T6192 T6204 nsubjpass blocking,observed
R4297 T6193 T6192 prep of,blocking
R4298 T6108 T6107 punct ",",al.
R4299 T6194 T6193 pobj translocation,of
R4300 T6195 T6194 prep of,translocation
R4301 T6196 T6197 compound transcription,factors
R4302 T6109 T6107 npadvmod 2007,al.
R4303 T6197 T6195 pobj factors,of
R4304 T6198 T6192 prep to,blocking
R4305 T6199 T6200 det the,nuclei
R4306 T6110 T6107 punct ;,al.
R4307 T6200 T6198 pobj nuclei,to
R4308 T6201 T6192 prep by,blocking
R4309 T6202 T6201 pobj Wwox,by
R4310 T6111 T6113 compound Salah,al.
R4311 T6203 T6204 auxpass was,observed
R4312 T6204 T6204 ROOT observed,observed
R4313 T6205 T6204 punct .,observed
R4314 T6112 T6113 nmod et,al.
R4315 T6206 T6212 prep Under,activated
R4316 T6207 T6208 compound stress,conditions
R4317 T6208 T6206 pobj conditions,Under
R4318 T6113 T6107 conj al.,al.
R4319 T6209 T6212 punct ",",activated
R4320 T6210 T6212 nsubjpass WWOX,activated
R4321 T6114 T6113 punct ",",al.
R4322 T6211 T6212 auxpass is,activated
R4323 T6212 T6212 ROOT activated,activated
R4324 T6213 T6212 prep via,activated
R4325 T6214 T6213 pobj phosphorylation,via
R4326 T6215 T6212 prep at,activated
R4327 T6216 T6215 pobj Tyr33,at
R4328 T6115 T6113 appos 2012,al.
R4329 T6217 T6212 punct ",",activated
R4330 T6218 T6212 cc and,activated
R4331 T6219 T6212 conj binds,activated
R4332 T6116 T6103 punct ;,others
R4333 T6220 T6219 dobj proteins,binds
R4334 T6221 T6219 advmod independently,binds
R4335 T6222 T6221 prep of,independently
R4336 T6117 T6119 compound Su,al.
R4337 T6118 T6119 compound et,al.
R4338 T6119 T6103 conj al.,others
R4339 T6120 T6119 punct ",",al.
R4340 T6223 T6225 det the,motif
R4341 T6224 T6225 compound PPxY,motif
R4342 T6121 T6119 npadvmod 2012,al.
R4343 T6225 T6222 pobj motif,of
R4344 T6226 T6229 punct (,al.
R4345 T6227 T6229 compound Chang,al.
R4346 T6122 T6103 punct ;,others
R4347 T6228 T6229 nmod et,al.
R4348 T6229 T6219 parataxis al.,binds
R4349 T6230 T6229 punct ",",al.
R4350 T6123 T6089 appos Figure,p73
R4351 T6231 T6229 npadvmod 2001,al.
R4352 T6232 T6231 punct ",",2001
R4353 T6233 T6231 conj 2003,2001
R4354 T6124 T6123 nummod 1,Figure
R4355 T6234 T6229 punct ",",al.
R4356 T6235 T6229 appos 2005a,al.
R4357 T6236 T6229 punct ",",al.
R4358 T6125 T6123 punct ),Figure
R4359 T6237 T6229 conj b,al.
R4360 T6238 T6237 punct ",",b
R4361 T6239 T6237 npadvmod 2007,b
R4362 T6320 T6322 nmod Bouteille,al.
R4363 T6240 T6239 punct ",",2007
R4364 T6241 T6239 conj 2010,2007
R4365 T6321 T6322 nmod et,al.
R4366 T6242 T6237 punct ),b
R4367 T6322 T6308 conj al.,Dvl-2
R4368 T6243 T6212 punct .,activated
R4369 T6244 T6245 compound Activated,WWOX
R4370 T6245 T6247 nsubj WWOX,interacts
R4371 T6323 T6322 punct ",",al.
R4372 T6246 T6247 advmod physically,interacts
R4373 T6247 T6247 ROOT interacts,interacts
R4374 T6248 T6247 prep with,interacts
R4375 T6249 T6251 nmod serine,p53
R4376 T6324 T6322 pobj 2009,al.
R4377 T6250 T6251 amod 46-phosphorylated,p53
R4378 T6251 T6248 pobj p53,with
R4379 T6252 T6253 punct (,Figure
R4380 T6325 T6308 punct ),Dvl-2
R4381 T6253 T6251 appos Figure,p53
R4382 T6254 T6253 nummod 1,Figure
R4383 T6255 T6253 punct ),Figure
R4384 T6326 T6305 punct .,overexpressed
R4385 T6256 T6251 punct ",",p53
R4386 T6257 T6258 nsubj which,stabilizes
R4387 T6258 T6251 relcl stabilizes,p53
R4388 T6327 T6328 compound Overexpressed,WWOX
R4389 T6259 T6258 dobj p53,stabilizes
R4390 T6328 T6329 nsubj WWOX,induces
R4391 T6260 T6259 cc and,p53
R4392 T6329 T6329 ROOT induces,induces
R4393 T6330 T6329 dobj apoptosis,induces
R4394 T6261 T6263 poss its,function
R4395 T6331 T6329 cc and,induces
R4396 T6262 T6263 amod apoptotic,function
R4397 T6332 T6329 conj inhibits,induces
R4398 T6263 T6259 conj function,p53
R4399 T6333 T6332 dobj proliferation,inhibits
R4400 T6334 T6333 prep of,proliferation
R4401 T6264 T6251 punct (,p53
R4402 T6265 T6267 compound Chang,al.
R4403 T6335 T6337 amod human,carcinoma
R4404 T6266 T6267 nmod et,al.
R4405 T6267 T6251 appos al.,p53
R4406 T6336 T6337 compound hepatic,carcinoma
R4407 T6268 T6267 punct ",",al.
R4408 T6269 T6267 appos 2005b,al.
R4409 T6270 T6251 punct ),p53
R4410 T6337 T6338 compound carcinoma,cells
R4411 T6271 T6247 punct .,interacts
R4412 T6272 T6275 advmod Also,binds
R4413 T6338 T6334 pobj cells,of
R4414 T6273 T6275 punct ",",binds
R4415 T6274 T6275 nsubj WWOX,binds
R4416 T6275 T6275 ROOT binds,binds
R4417 T6339 T6332 punct (,inhibits
R4418 T6276 T6277 amod Disheveled,proteins
R4419 T6277 T6275 dobj proteins,binds
R4420 T6278 T6279 punct (,Dvl
R4421 T6340 T6342 compound Hu,al.
R4422 T6279 T6275 npadvmod Dvl,binds
R4423 T6280 T6279 punct ),Dvl
R4424 T6281 T6275 punct ",",binds
R4425 T6282 T6283 nsubj which,are
R4426 T6283 T6275 relcl are,binds
R4427 T6284 T6285 amod key,components
R4428 T6341 T6342 nmod et,al.
R4429 T6285 T6283 attr components,are
R4430 T6286 T6285 prep in,components
R4431 T6287 T6289 compound Wnt,β-catenin
R4432 T6342 T6332 appos al.,inhibits
R4433 T6288 T6289 compound /,β-catenin
R4434 T6289 T6291 compound β-catenin,pathway
R4435 T6290 T6291 compound signaling,pathway
R4436 T6343 T6342 punct ",",al.
R4437 T6291 T6286 pobj pathway,in
R4438 T6292 T6291 punct (,pathway
R4439 T6293 T6291 appos Figure,pathway
R4440 T6344 T6342 npadvmod 2012,al.
R4441 T6294 T6293 nummod 1,Figure
R4442 T6295 T6291 punct ),pathway
R4443 T6296 T6275 punct .,binds
R4444 T6297 T6299 det No,motif
R4445 T6345 T6332 punct ),inhibits
R4446 T6298 T6299 compound PPxY,motif
R4447 T6299 T6300 nsubj motif,is
R4448 T6300 T6300 ROOT is,is
R4449 T6301 T6300 prep in,is
R4450 T6346 T6332 cc and,inhibits
R4451 T6302 T6301 pobj Dvl,in
R4452 T6303 T6300 punct .,is
R4453 T6347 T6350 amod many,types
R4454 T6348 T6349 compound cancer,cell
R4455 T6304 T6305 advmod Transiently,overexpressed
R4456 T6349 T6350 compound cell,types
R4457 T6305 T6305 ROOT overexpressed,overexpressed
R4458 T6350 T6332 conj types,inhibits
R4459 T6306 T6307 compound WWOX,sequesters
R4460 T6307 T6308 compound sequesters,Dvl-2
R4461 T6351 T6332 punct (,inhibits
R4462 T6308 T6305 nsubjpass Dvl-2,overexpressed
R4463 T6309 T6308 prep in,Dvl-2
R4464 T6310 T6311 det the,cytoplasm
R4465 T6352 T6354 compound Chang,al.
R4466 T6311 T6309 pobj cytoplasm,in
R4467 T6312 T6309 cc and,in
R4468 T6353 T6354 nmod et,al.
R4469 T6313 T6314 advmod thereby,blocks
R4470 T6314 T6322 nmod blocks,al.
R4471 T6315 T6318 nmod Dvl-2-mediated,activity
R4472 T6316 T6318 nmod TCF,activity
R4473 T6354 T6332 appos al.,inhibits
R4474 T6317 T6318 amod transcriptional,activity
R4475 T6318 T6322 nmod activity,al.
R4476 T6319 T6322 punct (,al.
R4477 T6355 T6354 punct ",",al.
R4478 T6356 T6354 appos 2007,al.
R4479 T6417 T6414 conj stress,chemicals
R4480 T6357 T6356 punct ",",2007
R4481 T6418 T6417 punct ",",stress
R4482 T6419 T6420 amod such,as
R4483 T6358 T6356 conj 2010,2007
R4484 T6359 T6354 punct ;,al.
R4485 T6420 T6414 prep as,chemicals
R4486 T6360 T6362 compound Salah,al.
R4487 T6421 T6422 compound UV,irradiation
R4488 T6361 T6362 nmod et,al.
R4489 T6422 T6420 pobj irradiation,as
R4490 T6423 T6422 cc and,irradiation
R4491 T6424 T6425 amod chemotherapeutic,drugs
R4492 T6362 T6354 conj al.,al.
R4493 T6425 T6422 conj drugs,irradiation
R4494 T6426 T6428 punct ",",undergoes
R4495 T6363 T6362 punct ",",al.
R4496 T6427 T6428 nsubj WWOX,undergoes
R4497 T6428 T6428 ROOT undergoes,undergoes
R4498 T6429 T6428 dobj phosphorylation,undergoes
R4499 T6364 T6362 npadvmod 2012,al.
R4500 T6430 T6428 prep in,undergoes
R4501 T6365 T6332 punct ;,inhibits
R4502 T6431 T6430 pobj Tyr33,in
R4503 T6432 T6431 cc and,Tyr33
R4504 T6433 T6434 advmod probably,others
R4505 T6366 T6368 compound Su,al.
R4506 T6434 T6431 conj others,Tyr33
R4507 T6435 T6430 pobj sites,in
R4508 T6436 T6435 punct ",",sites
R4509 T6367 T6368 compound et,al.
R4510 T6437 T6435 acl followed,sites
R4511 T6438 T6437 agent by,followed
R4512 T6439 T6438 pcomp relocating,by
R4513 T6440 T6439 prep to,relocating
R4514 T6368 T6332 conj al.,inhibits
R4515 T6441 T6440 pobj mitochondria,to
R4516 T6442 T6441 cc or,mitochondria
R4517 T6369 T6368 punct ",",al.
R4518 T6443 T6441 conj nuclei,mitochondria
R4519 T6444 T6439 prep for,relocating
R4520 T6445 T6444 pcomp inducing,for
R4521 T6370 T6368 npadvmod 2012,al.
R4522 T6446 T6445 dobj apoptosis,inducing
R4523 T6447 T6450 punct (,al.
R4524 T6448 T6450 compound Chang,al.
R4525 T6449 T6450 nmod et,al.
R4526 T6450 T6450 ROOT al.,al.
R4527 T6451 T6450 punct ",",al.
R4528 T6371 T6368 punct ),al.
R4529 T6452 T6450 npadvmod 2007,al.
R4530 T6453 T6452 punct ",",2007
R4531 T6454 T6452 conj 2010,2007
R4532 T6455 T6450 punct ),al.
R4533 T6372 T6329 punct .,induces
R4534 T6456 T6450 punct .,al.
R4535 T6457 T6458 nsubj WWOX,binds
R4536 T6458 T6458 ROOT binds,binds
R4537 T6373 T6374 nsubj WWOX,enhances
R4538 T6459 T6458 dobj MEK,binds
R4539 T6460 T6458 prep in,binds
R4540 T6461 T6462 compound Jurkat,T
R4541 T6374 T6374 ROOT enhances,enhances
R4542 T6462 T6463 compound T,cells
R4543 T6463 T6460 pobj cells,in
R4544 T6375 T6377 det the,function
R4545 T6464 T6467 punct (,al.
R4546 T6465 T6467 compound Lin,al.
R4547 T6466 T6467 nmod et,al.
R4548 T6467 T6458 npadvmod al.,binds
R4549 T6376 T6377 amod cytotoxic,function
R4550 T6468 T6467 punct ",",al.
R4551 T6469 T6467 npadvmod 2011,al.
R4552 T6377 T6374 dobj function,enhances
R4553 T6378 T6377 prep of,function
R4554 T6379 T6380 compound tumor,necrosis
R4555 T6470 T6467 punct ),al.
R4556 T6471 T6458 punct .,binds
R4557 T6380 T6381 compound necrosis,factor
R4558 T6472 T6474 nmod Phorbol,acetate
R4559 T6473 T6474 compound myristate,acetate
R4560 T6381 T6378 pobj factor,of
R4561 T6474 T6478 nsubj acetate,dissociates
R4562 T6475 T6476 punct (,PMA
R4563 T6476 T6474 appos PMA,acetate
R4564 T6382 T6377 prep by,function
R4565 T6477 T6474 punct ),acetate
R4566 T6478 T6478 ROOT dissociates,dissociates
R4567 T6383 T6386 amod down-regulating,Bcl-2
R4568 T6479 T6481 det the,complex
R4569 T6480 T6481 compound MEK/WWOX,complex
R4570 T6481 T6478 dobj complex,dissociates
R4571 T6482 T6478 cc and,dissociates
R4572 T6384 T6385 compound apoptosis,inhibitor
R4573 T6483 T6478 conj induces,dissociates
R4574 T6484 T6483 dobj WWOX,induces
R4575 T6485 T6486 aux to,translocate
R4576 T6486 T6483 xcomp translocate,induces
R4577 T6487 T6486 prep to,translocate
R4578 T6488 T6489 det the,mitochondria
R4579 T6385 T6386 compound inhibitor,Bcl-2
R4580 T6489 T6487 pobj mitochondria,to
R4581 T6490 T6491 aux to,induce
R4582 T6491 T6486 advcl induce,translocate
R4583 T6386 T6382 pobj Bcl-2,by
R4584 T6492 T6491 dobj apoptosis,induce
R4585 T6493 T6483 punct ",",induces
R4586 T6494 T6496 mark whereas,relocates
R4587 T6495 T6496 nsubj MEK,relocates
R4588 T6387 T6386 cc and,Bcl-2
R4589 T6496 T6483 advcl relocates,induces
R4590 T6497 T6496 prep to,relocates
R4591 T6498 T6500 det the,raft
R4592 T6388 T6392 nmod Bcl-xL,p53
R4593 T6499 T6500 amod lipid,raft
R4594 T6389 T6388 cc and,Bcl-xL
R4595 T6390 T6388 conj up-regulating,Bcl-xL
R4596 T6500 T6497 pobj raft,to
R4597 T6391 T6392 amod apoptotic,p53
R4598 T6392 T6386 conj p53,Bcl-2
R4599 T6501 T6478 punct .,dissociates
R4600 T6502 T6506 nsubj Inhibition,increases
R4601 T6393 T6396 punct (,al.
R4602 T6503 T6502 prep of,Inhibition
R4603 T6504 T6505 compound MEK,activity
R4604 T6505 T6503 pobj activity,of
R4605 T6394 T6396 compound Chang,al.
R4606 T6506 T6506 ROOT increases,increases
R4607 T6507 T6508 amod TMZ-induced,suppression
R4608 T6508 T6506 dobj suppression,increases
R4609 T6395 T6396 nmod et,al.
R4610 T6509 T6508 prep of,suppression
R4611 T6510 T6511 compound cancer,cell
R4612 T6396 T6396 ROOT al.,al.
R4613 T6511 T6512 compound cell,growth
R4614 T6512 T6509 pobj growth,of
R4615 T6513 T6516 punct (,al.
R4616 T6397 T6396 punct ",",al.
R4617 T6398 T6396 npadvmod 2001,al.
R4618 T6399 T6396 punct ),al.
R4619 T6514 T6516 compound Holt,al.
R4620 T6400 T6396 punct .,al.
R4621 T6515 T6516 nmod et,al.
R4622 T6516 T6506 npadvmod al.,increases
R4623 T6401 T6404 advmod Also,mediates
R4624 T6517 T6516 punct ",",al.
R4625 T6518 T6516 npadvmod 2012,al.
R4626 T6519 T6516 punct ),al.
R4627 T6520 T6506 punct .,increases
R4628 T6521 T6522 amod Ectopic,expression
R4629 T6522 T6528 nsubj expression,induces
R4630 T6402 T6404 punct ",",mediates
R4631 T6523 T6522 prep of,expression
R4632 T6524 T6523 pobj WWOX,of
R4633 T6525 T6522 prep in,expression
R4634 T6403 T6404 nsubj WWOX,mediates
R4635 T6526 T6527 compound A549,cells
R4636 T6527 T6525 pobj cells,in
R4637 T6528 T6528 ROOT induces,induces
R4638 T6404 T6404 ROOT mediates,mediates
R4639 T6529 T6532 amod procaspase-3,activation
R4640 T6530 T6529 cc and,procaspase-3
R4641 T6405 T6406 compound cell,death
R4642 T6531 T6529 conj procaspase-9,procaspase-3
R4643 T6532 T6528 dobj activation,induces
R4644 T6533 T6528 cc and,induces
R4645 T6406 T6404 dobj death,mediates
R4646 T6534 T6528 conj induces,induces
R4647 T6535 T6536 compound cytochrome,C
R4648 T6536 T6534 dobj C,induces
R4649 T6537 T6534 advcl releasing,induces
R4650 T6407 T6404 advmod synergistically,mediates
R4651 T6538 T6537 prep from,releasing
R4652 T6539 T6540 det the,mitochondria
R4653 T6408 T6404 prep with,mediates
R4654 T6540 T6538 pobj mitochondria,from
R4655 T6541 T6540 punct (,mitochondria
R4656 T6542 T6544 compound Zhang,al.
R4657 T6409 T6408 pobj p53,with
R4658 T6543 T6544 nmod et,al.
R4659 T6544 T6540 appos al.,mitochondria
R4660 T6545 T6540 punct ",",mitochondria
R4661 T6410 T6404 punct .,mediates
R4662 T6546 T6540 amod 2012a,mitochondria
R4663 T6547 T6534 punct ),induces
R4664 T6411 T6428 prep Upon,undergoes
R4665 T6548 T6528 punct .,induces
R4666 T6549 T6550 compound Complement,C1q
R4667 T6550 T6551 nsubj C1q,induces
R4668 T6412 T6411 pobj exposure,Upon
R4669 T6551 T6551 ROOT induces,induces
R4670 T6552 T6554 amod ectopic,phosphorylation
R4671 T6413 T6412 prep to,exposure
R4672 T6553 T6554 compound WWOX,phosphorylation
R4673 T6554 T6551 dobj phosphorylation,induces
R4674 T6414 T6413 pobj chemicals,to
R4675 T6555 T6554 prep in,phosphorylation
R4676 T6556 T6555 pobj Try33,in
R4677 T6557 T6551 cc and,induces
R4678 T6558 T6551 conj leads,induces
R4679 T6559 T6558 prep to,leads
R4680 T6415 T6414 cc or,chemicals
R4681 T6560 T6561 compound cell,apoptosis
R4682 T6561 T6559 pobj apoptosis,to
R4683 T6416 T6417 amod environmental,stress
R4684 T6562 T6561 advmod independently,apoptosis
R4685 T6563 T6561 prep of,apoptosis
R4686 T6564 T6568 det the,pathway
R4687 T6611 T6609 dobj factor,Transforming
R4688 T6565 T6568 amod classical,pathway
R4689 T6566 T6568 compound complement,pathway
R4690 T6567 T6568 compound activation,pathway
R4691 T6568 T6563 pobj pathway,of
R4692 T6612 T6613 nummod β1,binds
R4693 T6569 T6572 punct (,al.
R4694 T6570 T6572 nmod Hong,al.
R4695 T6571 T6572 nmod et,al.
R4696 T6613 T6609 nsubj binds,Transforming
R4697 T6572 T6561 appos al.,apoptosis
R4698 T6573 T6572 punct ",",al.
R4699 T6574 T6572 npadvmod 2009,al.
R4700 T6614 T6613 dobj Hyal-2,binds
R4701 T6575 T6558 punct ),leads
R4702 T6576 T6551 punct .,induces
R4703 T6577 T6578 det A,portion
R4704 T6578 T6582 nsubjpass portion,anchored
R4705 T6615 T6614 prep as,Hyal-2
R4706 T6579 T6578 prep of,portion
R4707 T6616 T6618 det a,receptor
R4708 T6580 T6579 pobj WWOX,of
R4709 T6617 T6618 compound cognate,receptor
R4710 T6618 T6615 pobj receptor,as
R4711 T6581 T6582 auxpass is,anchored
R4712 T6582 T6582 ROOT anchored,anchored
R4713 T6619 T6620 aux to,signal
R4714 T6583 T6582 prep in,anchored
R4715 T6584 T6586 det the,area
R4716 T6620 T6613 advcl signal,binds
R4717 T6585 T6586 amod membrane/cytoskeleton,area
R4718 T6586 T6583 pobj area,in
R4719 T6587 T6582 prep via,anchored
R4720 T6621 T6622 det the,formation
R4721 T6588 T6587 amod binding,via
R4722 T6589 T6588 prep with,binding
R4723 T6622 T6620 dobj formation,signal
R4724 T6590 T6591 compound hyaluronidase,Hyal-2
R4725 T6591 T6589 pobj Hyal-2,with
R4726 T6592 T6595 punct (,al.
R4727 T6593 T6595 compound Hsu,al.
R4728 T6594 T6595 nmod et,al.
R4729 T6595 T6591 appos al.,Hyal-2
R4730 T6623 T6622 prep of,formation
R4731 T6596 T6595 punct ",",al.
R4732 T6597 T6595 npadvmod 2009,al.
R4733 T6624 T6629 det the,complex
R4734 T6598 T6595 punct ),al.
R4735 T6599 T6591 cc and,Hyal-2
R4736 T6600 T6591 conj Phospho-Ezrin,Hyal-2
R4737 T6625 T6628 compound WWOX/Hyal,Smad4
R4738 T6601 T6604 punct (,al.
R4739 T6602 T6604 compound Jin,al.
R4740 T6603 T6604 nmod et,al.
R4741 T6626 T6627 compound -2,/
R4742 T6604 T6600 parataxis al.,Phospho-Ezrin
R4743 T6605 T6604 punct ",",al.
R4744 T6606 T6604 npadvmod 2006,al.
R4745 T6627 T6628 compound /,Smad4
R4746 T6607 T6604 punct ),al.
R4747 T6608 T6582 punct .,anchored
R4748 T6609 T6609 ROOT Transforming,Transforming
R4749 T6628 T6629 compound Smad4,complex
R4750 T6610 T6611 compound growth,factor
R4751 T6629 T6623 pobj complex,of
R4752 T6630 T6631 aux to,relocate
R4753 T6631 T6620 xcomp relocate,signal
R4754 T6632 T6631 prep to,relocate
R4755 T6633 T6634 det the,nucleus
R4756 T6634 T6632 pobj nucleus,to
R4757 T6635 T6634 prep for,nucleus
R4758 T6636 T6635 pcomp enhancing,for
R4759 T6637 T6640 det the,activity
R4760 T6638 T6640 amod SMAD-driven,activity
R4761 T6639 T6640 compound promoter,activity
R4762 T6640 T6636 dobj activity,enhancing
R4763 T6641 T6644 punct (,al.
R4764 T6642 T6644 compound Hsu,al.
R4765 T6643 T6644 nmod et,al.
R4766 T6644 T6613 dep al.,binds
R4767 T6645 T6644 punct ",",al.
R4768 T6646 T6644 npadvmod 2009,al.
R4769 T6647 T6644 punct ),al.
R4770 T6648 T6609 punct .,Transforming
R5005 T7155 T7158 amod Activated,apoptosis
R5006 T7156 T7158 nmod p53,apoptosis
R5007 T7157 T7158 compound mediates,apoptosis
R5008 T7158 T7158 ROOT apoptosis,apoptosis
R5009 T7159 T7162 punct ",",arrest
R5010 T7160 T7161 compound cell,cycle
R5011 T7161 T7162 compound cycle,arrest
R5012 T7162 T7158 appos arrest,apoptosis
R5013 T7163 T7162 punct ",",arrest
R5014 T7164 T7162 appos senescence,arrest
R5015 T7165 T7162 punct ",",arrest
R5016 T7166 T7167 compound DNA,repair
R5017 T7167 T7162 appos repair,arrest
R5018 T7168 T7167 punct ",",repair
R5019 T7169 T7167 cc or,repair
R5020 T7170 T7167 conj metabolism,repair
R5021 T7171 T7167 punct (,repair
R5022 T7172 T7167 appos Lane,repair
R5023 T7173 T7172 cc and,Lane
R5024 T7174 T7172 conj Levine,Lane
R5025 T7175 T7174 punct ",",Levine
R5026 T7176 T7174 npadvmod 2010,Levine
R5027 T7177 T7174 punct ),Levine
R5028 T7178 T7162 punct .,arrest
R5029 T7179 T7181 det The,structures
R5030 T7180 T7181 amod primary,structures
R5031 T7181 T7188 nsubjpass structures,depicted
R5032 T7182 T7181 prep of,structures
R5033 T7183 T7182 pobj p53,of
R5034 T7184 T7183 cc and,p53
R5035 T7185 T7186 poss its,isoforms
R5036 T7186 T7188 nsubjpass isoforms,depicted
R5037 T7187 T7188 auxpass are,depicted
R5038 T7188 T7188 ROOT depicted,depicted
R5039 T7189 T7190 punct (,Figure
R5040 T7190 T7188 oprd Figure,depicted
R5041 T7191 T7190 nummod 2,Figure
R5042 T7192 T7190 punct ),Figure
R5043 T7193 T7188 punct .,depicted
R5044 T7194 T7195 nsubj p53,induces
R5045 T7195 T7195 ROOT induces,induces
R5046 T7196 T7197 compound cell,cycle
R5047 T7197 T7198 compound cycle,arrest
R5048 T7198 T7195 dobj arrest,induces
R5049 T7199 T7195 prep by,induces
R5050 T7200 T7199 pcomp transactivating,by
R5051 T7201 T7200 dobj genes,transactivating
R5052 T7202 T7203 amod such,as
R5053 T7203 T7201 prep as,genes
R5054 T7204 T7206 amod cyclin-dependent,inhibitor
R5055 T7205 T7206 compound kinase,inhibitor
R5056 T7206 T7203 pobj inhibitor,as
R5057 T7207 T7206 nummod p21,inhibitor
R5058 T7208 T7207 punct ",",p21
R5059 T7209 T7206 cc or,inhibitor
R5060 T7210 T7211 compound microRNA,miR34
R5061 T7211 T7206 conj miR34,inhibitor
R5062 T7212 T7195 punct .,induces
R5063 T7213 T7214 nsubj p53,induces
R5064 T7214 T7214 ROOT induces,induces
R5065 T7215 T7214 dobj apoptosis,induces
R5066 T7216 T7214 prep by,induces
R5067 T7217 T7216 pcomp transactivating,by
R5068 T7218 T7219 amod proapoptotic,genes
R5069 T7219 T7217 dobj genes,transactivating
R5070 T7220 T7221 amod such,as
R5071 T7221 T7219 prep as,genes
R5072 T7222 T7221 pobj BAX,as
R5073 T7223 T7222 punct ",",BAX
R5074 T7224 T7222 conj PUMA,BAX
R5075 T7225 T7224 punct ",",PUMA
R5076 T7226 T7224 conj SCOTIN,PUMA
R5077 T7227 T7226 punct ",",SCOTIN
R5078 T7228 T7226 cc and,SCOTIN
R5079 T7229 T7226 conj FAS,SCOTIN
R5080 T7230 T7229 punct ",",FAS
R5081 T7231 T7217 cc and,transactivating
R5082 T7232 T7217 conj inhibiting,transactivating
R5083 T7233 T7236 det the,BCL-2
R5084 T7234 T7235 amod antiapoptotic,gene
R5085 T7235 T7236 compound gene,BCL-2
R5086 T7236 T7232 dobj BCL-2,inhibiting
R5087 T7237 T7236 punct (,BCL-2
R5088 T7238 T7236 appos Lane,BCL-2
R5089 T7239 T7238 cc and,Lane
R5090 T7240 T7238 conj Levine,Lane
R5091 T7241 T7240 punct ",",Levine
R5092 T7242 T7240 npadvmod 2010,Levine
R5093 T7243 T7240 punct ),Levine
R5094 T7244 T7214 punct .,induces
R5095 T7245 T7246 nsubj p53,triggers
R5096 T7246 T7246 ROOT triggers,triggers
R5097 T7247 T7251 amod pro-survival,response
R5098 T7248 T7247 cc or,pro-survival
R5099 T7249 T7247 conj cell,pro-survival
R5100 T7250 T7251 compound death,response
R5101 T7251 T7246 dobj response,triggers
R5102 T7252 T7246 punct ",",triggers
R5103 T7253 T7246 advcl depending,triggers
R5104 T7254 T7253 prep upon,depending
R5105 T7255 T7256 compound cell,types
R5106 T7256 T7254 pobj types,upon
R5107 T7257 T7253 punct ",",depending
R5108 T7258 T7259 det the,intensity
R5109 T7259 T7246 dobj intensity,triggers
R5110 T7260 T7259 prep of,intensity
R5111 T7261 T7263 det the,signal
R5112 T7262 T7263 compound stress,signal
R5113 T7263 T7260 pobj signal,of
R5114 T7264 T7259 punct ",",intensity
R5115 T7265 T7259 cc and,intensity
R5116 T7266 T7267 det the,extent
R5117 T7267 T7259 conj extent,intensity
R5118 T7268 T7267 prep of,extent
R5119 T7269 T7270 amod cellular,damage
R5120 T7270 T7268 pobj damage,of
R5121 T7271 T7274 punct (,al.
R5122 T7272 T7274 compound Menendez,al.
R5123 T7273 T7274 nmod et,al.
R5124 T7274 T7267 conj al.,extent
R5125 T7275 T7274 punct ",",al.
R5126 T7276 T7274 npadvmod 2009,al.
R5127 T7277 T7274 punct ),al.
R5128 T7278 T7246 punct .,triggers
R5129 T7279 T7282 advmod Also,plays
R5130 T7280 T7282 punct ",",plays
R5131 T7281 T7282 nsubj p53,plays
R5132 T7282 T7282 ROOT plays,plays
R5133 T7283 T7284 det a,role
R5134 T7284 T7282 dobj role,plays
R5135 T7285 T7284 prep in,role
R5136 T7286 T7285 pcomp controlling,in
R5137 T7287 T7288 compound cell,motility
R5138 T7288 T7286 dobj motility,controlling
R5139 T7289 T7286 prep via,controlling
R5140 T7290 T7289 pcomp regulating,via
R5141 T7291 T7292 det the,expression
R5142 T7292 T7290 dobj expression,regulating
R5143 T7293 T7292 prep of,expression
R5144 T7294 T7296 amod smooth,α-actin
R5145 T7295 T7296 compound muscle,α-actin
R5146 T7296 T7293 pobj α-actin,of
R5147 T7297 T7300 punct (,al.
R5148 T7298 T7300 compound Comer,al.
R5149 T7299 T7300 nmod et,al.
R5150 T7300 T7292 appos al.,expression
R5151 T7301 T7300 punct ",",al.
R5166 T7316 T7312 punct ",",al.
R5167 T7317 T7312 cc and,al.
R5168 T7318 T7319 amod many,others
R5169 T7319 T7312 conj others,al.
R5170 T7320 T7282 punct .,plays
R5527 T7989 T7990 advmod At,least
R5528 T7990 T7991 advmod least,nine
R5529 T7991 T7992 nummod nine,isoforms
R5530 T7992 T7997 nsubjpass isoforms,identified
R5531 T7993 T7992 prep of,isoforms
R5532 T7994 T7993 pobj p53,of
R5533 T7995 T7997 aux have,identified
R5534 T7996 T7997 auxpass been,identified
R5535 T7997 T7997 ROOT identified,identified
R5536 T7998 T8002 amod due,splicing
R5537 T7999 T8000 aux to,alternative
R5538 T8000 T7998 xcomp alternative,due
R5539 T8001 T8002 compound mRNA,splicing
R5540 T8002 T7997 dobj splicing,identified
R5541 T8003 T8002 punct ",",splicing
R5542 T8004 T8006 amod multiple,promoters
R5543 T8005 T8006 compound gene,promoters
R5544 T8006 T8002 conj promoters,splicing
R5545 T8007 T8006 punct ",",promoters
R5546 T8008 T8006 cc and,promoters
R5547 T8009 T8011 amod alternative,sites
R5548 T8010 T8011 compound initiation,sites
R5549 T8011 T8006 conj sites,promoters
R5550 T8012 T8011 prep of,sites
R5551 T8013 T8012 pobj translation,of
R5552 T8014 T8002 punct (,splicing
R5553 T8015 T8017 compound Ghosh,al.
R5554 T8016 T8017 nmod et,al.
R5555 T8017 T8002 appos al.,splicing
R5556 T8018 T8017 punct ",",al.
R5557 T8019 T8017 appos 2004,al.
R5558 T8020 T8002 punct ;,splicing
R5559 T8021 T8023 compound Ray,al.
R5560 T8022 T8023 nmod et,al.
R5561 T8023 T8002 conj al.,splicing
R5562 T8024 T8023 punct ",",al.
R5563 T8025 T8023 appos 2006,al.
R5564 T8026 T8023 punct ;,al.
R5565 T8027 T8023 appos Figure,al.
R5566 T8028 T8027 nummod 2,Figure
R5567 T8029 T8023 punct ),al.
R5568 T8030 T7997 punct .,identified
R5569 T8031 T8039 prep In,occurs
R5570 T8032 T8031 pobj cancers,In
R5571 T8033 T8035 punct ",",expression
R5572 T8034 T8035 amod aberrant,expression
R5573 T8035 T8039 nsubj expression,occurs
R5574 T8036 T8035 prep of,expression
R5575 T8037 T8038 compound p53,isoforms
R5576 T8038 T8036 pobj isoforms,of
R5577 T8039 T8039 ROOT occurs,occurs
R5578 T8040 T8039 advmod frequently,occurs
R5579 T8041 T8044 punct (,al.
R5580 T8042 T8044 nmod Bourdon,al.
R5581 T8043 T8044 nmod et,al.
R5582 T8044 T8039 parataxis al.,occurs
R5583 T8045 T8044 punct ",",al.
R5584 T8046 T8044 npadvmod 2005,al.
R5585 T8047 T8048 punct ;,Bourdon
R5586 T8048 T8039 nsubj Bourdon,occurs
R5587 T8049 T8048 punct ",",Bourdon
R5588 T8050 T8048 npadvmod 2007,Bourdon
R5589 T8051 T8048 punct ),Bourdon
R5590 T8052 T8039 punct .,occurs
R5591 T8053 T8054 amod Full-length,p53
R5592 T8054 T8061 nsubjpass p53,localized
R5593 T8055 T8054 punct ",",p53
R5594 T8056 T8054 conj Δ133p53,p53
R5595 T8057 T8056 punct ",",Δ133p53
R5596 T8058 T8056 cc and,Δ133p53
R5597 T8059 T8056 conj p53β,Δ133p53
R5598 T8060 T8061 auxpass are,localized
R5599 T8061 T8061 ROOT localized,localized
R5600 T8062 T8063 advmod mainly,in
R5601 T8063 T8061 prep in,localized
R5602 T8064 T8065 det the,nucleus
R5603 T8065 T8063 pobj nucleus,in
R5604 T8066 T8061 punct ",",localized
R5605 T8067 T8061 cc and,localized
R5606 T8068 T8069 advmod only,few
R5607 T8069 T8072 nsubj few,are
R5608 T8070 T8069 prep of,few
R5609 T8071 T8070 pobj them,of
R5610 T8072 T8061 conj are,localized
R5611 T8073 T8072 prep in,are
R5612 T8074 T8073 pobj cytoplasm,in
R5613 T8075 T8072 punct .,are
R5614 T8076 T8080 nsubjpass p53γ,localized
R5615 T8077 T8076 cc and,p53γ
R5616 T8078 T8076 conj Δ133p53β,p53γ
R5617 T8079 T8080 auxpass are,localized
R5618 T8080 T8080 ROOT localized,localized
R5619 T8081 T8080 prep in,localized
R5620 T8082 T8083 det the,nucleus
R5621 T8083 T8081 pobj nucleus,in
R5622 T8084 T8083 cc and,nucleus
R5623 T8085 T8083 conj cytoplasm,nucleus
R5624 T8086 T8080 punct .,localized
R5625 T8087 T8089 nsubjpass Δ133p53γ,localized
R5626 T8088 T8089 auxpass is,localized
R5627 T8089 T8089 ROOT localized,localized
R5628 T8090 T8089 prep in,localized
R5629 T8091 T8092 det the,cytoplasm
R5630 T8092 T8090 pobj cytoplasm,in
R5631 T8093 T8096 punct (,al.
R5632 T8094 T8096 compound Bourdon,al.
R5633 T8095 T8096 nmod et,al.
R5634 T8096 T8089 npadvmod al.,localized
R5635 T8097 T8096 punct ",",al.
R5636 T8098 T8096 npadvmod 2005,al.
R5637 T8099 T8096 punct ),al.
R5638 T8100 T8089 punct .,localized
R5639 T8101 T8106 nmod Co-transfection,increases
R5640 T8102 T8101 prep of,Co-transfection
R5641 T8103 T8102 pobj p53,of
R5642 T8104 T8103 cc and,p53
R5643 T8105 T8106 amod p53β,increases
R5644 T8106 T8106 ROOT increases,increases
R5645 T8107 T8108 compound p53-mediated,apoptosis
R5646 T8108 T8106 dobj apoptosis,increases
R5647 T8109 T8106 punct ",",increases
R5648 T8110 T8122 nmod whereas,al.
R5649 T8111 T8122 dep co-expression,al.
R5650 T8112 T8111 prep of,co-expression
R5651 T8113 T8112 pobj p53,of
R5652 T8114 T8111 prep with,co-expression
R5653 T8115 T8116 amod Δ133p53,suppresses
R5654 T8116 T8114 pobj suppresses,with
R5655 T8117 T8118 nmod p53-mediated,apoptosis
R5656 T8118 T8111 conj apoptosis,co-expression
R5657 T8119 T8122 punct (,al.
R5658 T8120 T8122 compound Bourdon,al.
R5659 T8121 T8122 nmod et,al.
R5660 T8122 T8106 advcl al.,increases
R5661 T8123 T8122 punct ",",al.
R5662 T8124 T8122 npadvmod 2005,al.
R5663 T8125 T8122 punct ),al.
R5664 T8126 T8106 punct .,increases
R5665 T8127 T8129 nsubj Δ133p53,regulates
R5666 T8128 T8129 advmod differentially,regulates
R5667 T8129 T8129 ROOT regulates,regulates
R5668 T8130 T8131 compound gene,expression
R5669 T8131 T8129 dobj expression,regulates
R5670 T8132 T8131 prep in,expression
R5671 T8133 T8132 pobj p53-dependent,in
R5672 T8134 T8129 cc and,regulates
R5673 T8135 T8129 punct -,regulates
R5674 T8136 T8137 amod independent,manners
R5675 T8137 T8129 conj manners,regulates
R5676 T8138 T8137 punct (,manners
R5677 T8139 T8141 compound Aoubala,al.
R5678 T8140 T8141 nmod et,al.
R5679 T8141 T8137 appos al.,manners
R5680 T8142 T8141 punct ",",al.
R5681 T8143 T8141 npadvmod 2011,al.
R5682 T8144 T8137 punct ),manners
R5683 T8145 T8129 punct .,regulates
R5684 T8146 T8155 nsubj Co-expression,affect
R5685 T8147 T8146 prep of,Co-expression
R5686 T8148 T8147 pobj Δ133p53β,of
R5687 T8149 T8148 cc or,Δ133p53β
R5688 T8150 T8148 conj Δ133p53γ,Δ133p53β
R5689 T8151 T8146 prep with,Co-expression
R5690 T8152 T8151 pobj p53,with
R5691 T8153 T8155 aux does,affect
R5692 T8154 T8155 neg not,affect
R5693 T8155 T8155 ROOT affect,affect
R5694 T8156 T8158 nmod p53,activity
R5695 T8157 T8158 compound transcriptional,activity
R5696 T8158 T8155 dobj activity,affect
R5697 T8159 T8158 prep on,activity
R5698 T8160 T8159 pobj p21,on
R5699 T8161 T8155 cc and,affect
R5700 T8162 T8163 compound Bax,promoters
R5701 T8163 T8163 ROOT promoters,promoters
R5702 T8164 T8163 punct ",",promoters
R5703 T8165 T8167 advmod as,as
R5704 T8166 T8167 advmod well,as
R5705 T8167 T8163 cc as,promoters
R5706 T8168 T8163 conj apoptosis,promoters
R5707 T8169 T8155 punct .,affect
R6238 T9180 T9181 compound p53,mutants
R6239 T9181 T9183 nsubjpass mutants,considered
R6240 T9182 T9183 auxpass are,considered
R6241 T9183 T9219 ccomp considered,al.
R6242 T9184 T9183 prep as,considered
R6243 T9185 T9186 amod unfavorable,factors
R6244 T9186 T9184 pobj factors,as
R6245 T9187 T9186 prep for,factors
R6246 T9188 T9189 det the,effectiveness
R6247 T9189 T9187 pobj effectiveness,for
R6248 T9190 T9189 prep in,effectiveness
R6249 T9191 T9194 amod radiotherapy,treatment
R6250 T9192 T9191 cc and,radiotherapy
R6251 T9193 T9194 compound TMZ,treatment
R6252 T9194 T9190 pobj treatment,in
R6253 T9195 T9189 prep in,effectiveness
R6254 T9196 T9197 compound glioma,cells
R6255 T9197 T9195 pobj cells,in
R6256 T9198 T9201 punct (,al.
R6257 T9199 T9201 nmod Gjerset,al.
R6258 T9200 T9201 nmod et,al.
R6259 T9201 T9186 appos al.,factors
R6260 T9202 T9201 punct ",",al.
R6261 T9203 T9201 npadvmod 1995,al.
R6262 T9204 T9219 punct ;,al.
R6263 T9205 T9207 compound Hirose,al.
R6264 T9206 T9207 nmod et,al.
R6265 T9207 T9219 ccomp al.,al.
R6266 T9208 T9207 punct ",",al.
R6267 T9209 T9207 npadvmod 2001,al.
R6268 T9210 T9219 punct ;,al.
R6269 T9211 T9213 compound Squatrito,al.
R6270 T9212 T9213 compound et,al.
R6271 T9213 T9219 ccomp al.,al.
R6272 T9214 T9213 punct ",",al.
R6273 T9215 T9213 npadvmod 2010,al.
R6274 T9216 T9219 punct ;,al.
R6275 T9217 T9219 compound Blough,al.
R6276 T9218 T9219 compound et,al.
R6277 T9219 T9219 ROOT al.,al.
R6278 T9220 T9219 punct ",",al.
R6279 T9221 T9219 npadvmod 2011,al.
R6280 T9222 T9219 punct ),al.
R6281 T9223 T9219 punct .,al.
R6282 T9224 T9228 nsubj Loss,confers
R6283 T9225 T9224 prep of,Loss
R6284 T9226 T9227 amod functional,p53
R6285 T9227 T9225 pobj p53,of
R6286 T9228 T9228 ROOT confers,confers
R6287 T9229 T9228 dobj sensitivity,confers
R6288 T9230 T9229 prep to,sensitivity
R6289 T9231 T9230 pobj TMZ,to
R6290 T9232 T9228 prep in,confers
R6291 T9233 T9234 amod glioma,cells
R6292 T9234 T9232 pobj cells,in
R6293 T9235 T9228 punct ",",confers
R6294 T9236 T9240 mark whereas,increases
R6295 T9237 T9239 amod wild,p53
R6296 T9238 T9239 compound type,p53
R6297 T9239 T9240 nsubj p53,increases
R6298 T9240 T9228 advcl increases,confers
R6299 T9241 T9243 det the,resistance
R6300 T9242 T9243 compound TMZ,resistance
R6301 T9243 T9240 dobj resistance,increases
R6302 T9244 T9240 punct (,increases
R6303 T9245 T9247 amod Blough,al.
R6304 T9246 T9247 nmod et,al.
R6305 T9247 T9240 npadvmod al.,increases
R6306 T9248 T9247 punct ",",al.
R6307 T9249 T9247 npadvmod 2011,al.
R6308 T9250 T9240 punct ),increases
R6309 T9251 T9228 punct .,confers
R6310 T9252 T9253 compound p53,mutants
R6311 T9253 T9254 nsubj mutants,reduce
R6312 T9254 T9254 ROOT reduce,reduce
R6313 T9255 T9256 compound TMZ,sensitivity
R6314 T9256 T9254 dobj sensitivity,reduce
R6315 T9257 T9256 prep in,sensitivity
R6316 T9258 T9257 pobj gliomas,in
R6317 T9259 T9262 punct (,al.
R6318 T9260 T9262 amod Blough,al.
R6319 T9261 T9262 nmod et,al.
R6320 T9262 T9254 advmod al.,reduce
R6321 T9263 T9262 punct ",",al.
R6322 T9264 T9262 npadvmod 2011,al.
R6323 T9265 T9262 punct ),al.
R6324 T9266 T9254 punct .,reduce
R6325 T9267 T9269 amod Altered,expression
R6326 T9268 T9269 compound WWOX,expression
R6327 T9269 T9271 nsubjpass expression,shown
R6328 T9270 T9271 auxpass is,shown
R6329 T9271 T9271 ROOT shown,shown
R6330 T9272 T9271 prep in,shown
R6331 T9273 T9272 pobj GBMs,in
R6332 T9274 T9273 punct ",",GBMs
R6333 T9275 T9281 prep in,associated
R6334 T9276 T9275 pobj which,in
R6335 T9277 T9281 nsubjpass downregulation,associated
R6336 T9278 T9277 prep of,downregulation
R6337 T9279 T9278 pobj WWOX,of
R6338 T9280 T9281 auxpass is,associated
R6339 T9281 T9271 conj associated,shown
R6340 T9282 T9281 prep with,associated
R6341 T9283 T9282 pobj loss,with
R6342 T9284 T9283 prep of,loss
R6343 T9285 T9284 pobj heterozygosity,of
R6344 T9286 T9285 cc and,heterozygosity
R6345 T9287 T9288 compound promoter,methylation
R6346 T9288 T9285 conj methylation,heterozygosity
R6347 T9289 T9292 punct (,al.
R6348 T9290 T9292 compound Kosla,al.
R6349 T9291 T9292 nmod et,al.
R6350 T9292 T9283 appos al.,loss
R6351 T9293 T9292 punct ",",al.
R6352 T9294 T9292 npadvmod 2011,al.
R6353 T9295 T9281 punct ),associated
R6354 T9296 T9271 punct .,shown
R6355 T9297 T9300 advmod Recently,demonstrated
R6356 T9298 T9300 punct ",",demonstrated
R6357 T9299 T9300 nsubj we,demonstrated
R6358 T9300 T9300 ROOT demonstrated,demonstrated
R6359 T9301 T9304 mark that,induces
R6360 T9302 T9303 compound overexpressed,WWOX
R6361 T9303 T9304 nsubj WWOX,induces
R6362 T9304 T9300 ccomp induces,demonstrated
R6363 T9305 T9304 dobj apoptosis,induces
R6364 T9306 T9305 prep of,apoptosis
R6365 T9307 T9309 amod glioblastoma,cells
R6366 T9308 T9309 compound U373-MG,cells
R6367 T9309 T9306 pobj cells,of
R6368 T9310 T9309 acl harboring,cells
R6369 T9311 T9312 amod mutant,p53
R6370 T9312 T9310 dobj p53,harboring
R6371 T9313 T9310 prep by,harboring
R6372 T9314 T9313 pcomp causing,by
R6373 T9315 T9318 amod hypoploidy,fragmentation
R6374 T9316 T9315 cc and,hypoploidy
R6375 T9317 T9315 conj DNA,hypoploidy
R6376 T9318 T9314 dobj fragmentation,causing
R6377 T9319 T9322 punct (,al.
R6378 T9320 T9322 compound Chiang,al.
R6379 T9321 T9322 nmod et,al.
R6380 T9322 T9314 ccomp al.,causing
R6381 T9323 T9322 punct ",",al.
R6382 T9324 T9322 npadvmod 2012,al.
R6383 T9325 T9322 punct ),al.
R6384 T9326 T9300 punct .,demonstrated
R6385 T9327 T9331 advmod However,has
R6386 T9328 T9331 punct ",",has
R6387 T9329 T9330 compound ectopic,WWOX
R6388 T9330 T9331 nsubj WWOX,has
R6389 T9331 T9331 ROOT has,has
R6390 T9332 T9333 det no,effect
R6391 T9333 T9331 dobj effect,has
R6392 T9334 T9333 prep with,effect
R6393 T9335 T9336 nsubj U87-MG,expressing
R6394 T9336 T9334 pcomp expressing,with
R6395 T9337 T9339 amod wild,p53
R6396 T9338 T9339 compound type,p53
R6397 T9339 T9336 dobj p53,expressing
R6398 T9340 T9331 punct .,has
R6399 T9341 T9345 prep Unlike,induces
R6400 T9342 T9341 pobj TMZ,Unlike
R6401 T9343 T9345 punct ",",induces
R6402 T9344 T9345 nsubj WWOX,induces
R6403 T9345 T9345 ROOT induces,induces
R6404 T9346 T9345 dobj apoptosis,induces
R6405 T9347 T9346 prep of,apoptosis
R6406 T9348 T9349 compound U373-MG,cells
R6407 T9349 T9347 pobj cells,of
R6408 T9350 T9345 prep via,induces
R6409 T9351 T9355 det a,pathway
R6410 T9352 T9355 amod mitochondria-independent,pathway
R6411 T9353 T9352 cc and,mitochondria-independent
R6412 T9354 T9352 conj caspase-3-independent,mitochondria-independent
R6413 T9355 T9350 pobj pathway,via
R6414 T9356 T9359 punct (,al.
R6415 T9357 T9359 compound Chiang,al.
R6416 T9358 T9359 nmod et,al.
R6417 T9359 T9345 advcl al.,induces
R6418 T9360 T9359 punct ",",al.
R6419 T9361 T9359 npadvmod 2012,al.
R6420 T9362 T9359 punct ),al.
R6421 T9363 T9345 punct .,induces
R6422 T9364 T9368 mark While,are
R6423 T9365 T9367 det the,mechanisms
R6424 T9366 T9367 amod underlying,mechanisms
R6425 T9367 T9368 nsubj mechanisms,are
R6426 T9368 T9372 advcl are,is
R6427 T9369 T9368 acomp unknown,are
R6428 T9370 T9372 punct ",",is
R6429 T9371 T9372 nsubj it,is
R6430 T9372 T9372 ROOT is,is
R6431 T9373 T9372 acomp reasonable,is
R6432 T9374 T9375 aux to,assume
R6433 T9375 T9372 xcomp assume,is
R6434 T9376 T9383 mark that,depends
R6435 T9377 T9378 det the,survival
R6436 T9378 T9383 nsubj survival,depends
R6437 T9379 T9378 prep of,survival
R6438 T9380 T9382 amod human,cells
R6439 T9381 T9382 compound glioblastoma,cells
R6440 T9382 T9379 pobj cells,of
R6441 T9383 T9375 ccomp depends,assume
R6442 T9384 T9383 prep upon,depends
R6443 T9385 T9384 pobj interactions,upon
R6444 T9386 T9385 prep between,interactions
R6445 T9387 T9388 det the,gain-of-function
R6446 T9388 T9386 pobj gain-of-function,between
R6447 T9389 T9388 prep of,gain-of-function
R6448 T9390 T9391 compound p53,mutants
R6449 T9391 T9389 pobj mutants,of
R6450 T9392 T9391 cc and,mutants
R6451 T9393 T9391 conj WWOX,mutants
R6452 T9394 T9372 punct .,is
R6453 T9395 T9396 compound Activated,WWOX
R6454 T9396 T9397 nsubj WWOX,binds
R6455 T9397 T9397 ROOT binds,binds
R6456 T9398 T9399 amod wild,type
R6457 T9399 T9400 compound type,p53
R6458 T9400 T9397 dobj p53,binds
R6459 T9401 T9397 prep with,binds
R6460 T9402 T9403 compound Ser46,phosphorylation
R6461 T9403 T9401 pobj phosphorylation,with
R6462 T9404 T9407 punct (,al.
R6463 T9405 T9407 compound Chang,al.
R6464 T9406 T9407 nmod et,al.
R6465 T9407 T9407 ROOT al.,al.
R6466 T9408 T9407 punct ",",al.
R6467 T9409 T9407 amod 2005b,al.
R6468 T9410 T9409 punct ),2005b
R6469 T9411 T9407 punct .,al.
R6470 T9412 T9413 compound UV,irradiation
R6471 T9413 T9414 nsubj irradiation,enhances
R6472 T9414 T9414 ROOT enhances,enhances
R6473 T9415 T9417 det the,interactions
R6474 T9416 T9417 amod binding,interactions
R6475 T9417 T9414 dobj interactions,enhances
R6476 T9418 T9414 punct .,enhances
R6477 T9419 T9433 prep Despite,remains
R6478 T9420 T9421 det the,presence
R6479 T9421 T9419 pobj presence,Despite
R6480 T9422 T9421 prep of,presence
R6481 T9423 T9422 pobj Ser46,of
R6482 T9424 T9421 prep in,presence
R6483 T9425 T9424 pobj Δ40p53,in
R6484 T9426 T9433 punct ",",remains
R6485 T9427 T9433 nsubj binding,remains
R6486 T9428 T9427 prep of,binding
R6487 T9429 T9430 det this,protein
R6488 T9430 T9428 pobj protein,of
R6489 T9431 T9427 prep with,binding
R6490 T9432 T9431 pobj WWOX,with
R6491 T9433 T9433 ROOT remains,remains
R6492 T9434 T9436 aux to,determined
R6493 T9435 T9436 auxpass be,determined
R6494 T9436 T9433 xcomp determined,remains
R6495 T9437 T9433 punct .,remains
R6496 T9438 T9439 nsubj We,postulate
R6497 T9439 T9439 ROOT postulate,postulate
R6498 T9440 T9453 mark that,appear
R6499 T9441 T9453 prep in,appear
R6500 T9442 T9443 compound GBM,cells
R6501 T9443 T9441 pobj cells,in
R6502 T9444 T9453 punct ",",appear
R6503 T9445 T9447 preconj both,type
R6504 T9446 T9447 amod wild,type
R6505 T9447 T9453 nsubj type,appear
R6506 T9448 T9452 nmod p53,proteins
R6507 T9449 T9448 cc and,p53
R6508 T9450 T9448 conj ectopic,p53
R6509 T9451 T9452 compound WWOX,proteins
R6510 T9452 T9453 nsubj proteins,appear
R6511 T9453 T9439 ccomp appear,postulate
R6512 T9454 T9455 aux to,have
R6513 T9455 T9453 xcomp have,appear
R6514 T9456 T9458 det a,antagonism
R6515 T9457 T9458 amod functional,antagonism
R6516 T9458 T9455 dobj antagonism,have
R6517 T9459 T9455 punct ",",have
R6518 T9460 T9461 advmod thereby,nullifying
R6519 T9461 T9455 advcl nullifying,have
R6520 T9462 T9463 det each,other
R6521 T9463 T9464 poss other,function
R6522 T9464 T9461 dobj function,nullifying
R6523 T9465 T9464 prep in,function
R6524 T9466 T9465 pcomp inducing,in
R6525 T9467 T9466 dobj apoptosis,inducing
R6526 T9468 T9469 punct (,Figure
R6527 T9469 T9464 appos Figure,function
R6528 T9470 T9469 nummod 2,Figure
R6529 T9471 T9469 punct ),Figure
R6530 T9472 T9439 punct .,postulate
R6531 T9473 T9475 amod Mutant,proteins
R6532 T9474 T9475 compound p53,proteins
R6533 T9475 T9478 nsubj proteins,bind
R6534 T9476 T9478 aux can,bind
R6535 T9477 T9478 neg not,bind
R6536 T9478 T9478 ROOT bind,bind
R6537 T9479 T9480 compound ectopic,WWOX
R6538 T9480 T9478 dobj WWOX,bind
R6539 T9481 T9480 prep in,WWOX
R6540 T9482 T9483 compound GBM,cells
R6541 T9483 T9481 pobj cells,in
R6542 T9484 T9478 punct ",",bind
R6543 T9485 T9478 cc and,bind
R6544 T9486 T9487 nsubj WWOX,is
R6545 T9487 T9478 conj is,bind
R6546 T9488 T9487 acomp able,is
R6547 T9489 T9490 aux to,induce
R6548 T9490 T9488 xcomp induce,able
R6549 T9491 T9490 dobj apoptosis,induce
R6550 T9492 T9487 punct .,is
R6551 T9493 T9495 mark Whether,causes
R6552 T9494 T9495 nsubj WWOX,causes
R6553 T9495 T9502 advcl causes,is
R6554 T9496 T9495 dobj apoptosis,causes
R6555 T9497 T9495 prep in,causes
R6556 T9498 T9499 nsubj GBM,expressing
R6557 T9499 T9497 pcomp expressing,in
R6558 T9500 T9501 compound p53,isoforms
R6559 T9501 T9499 dobj isoforms,expressing
R6560 T9502 T9502 ROOT is,is
R6561 T9503 T9502 acomp unknown,is
R6562 T9504 T9502 cc and,is
R6563 T9505 T9502 conj remains,is
R6564 T9506 T9508 aux to,established
R6565 T9507 T9508 auxpass be,established
R6566 T9508 T9505 xcomp established,remains
R6567 T9509 T9502 punct .,is
R6629 T9985 T9987 mark Whether,affects
R6630 T9986 T9987 nsubj WWOX,affects
R6631 T9987 T9993 advcl affects,determined
R6632 T9988 T9989 compound TMZ,sensitivity
R6633 T9989 T9987 dobj sensitivity,affects
R6634 T9990 T9993 aux has,determined
R6635 T9991 T9993 neg never,determined
R6636 T9992 T9993 auxpass been,determined
R6637 T9993 T9993 ROOT determined,determined
R6638 T9994 T9993 punct .,determined
R6639 T9995 T9996 amod Binding,proteins
R6640 T9996 T10001 nsubj proteins,are
R6641 T9997 T9996 prep for,proteins
R6642 T9998 T9997 pobj WWOX,for
R6643 T9999 T9998 cc and/or,WWOX
R6644 T10000 T9998 conj p53,WWOX
R6645 T10001 T10001 ROOT are,are
R6646 T10002 T10001 acomp likely,are
R6647 T10003 T10004 aux to,affect
R6648 T10004 T10002 xcomp affect,likely
R6649 T10005 T10004 dobj apoptosis,affect
R6650 T10006 T10005 cc and,apoptosis
R6651 T10007 T10008 compound TMZ,sensitivity
R6652 T10008 T10005 conj sensitivity,apoptosis
R6653 T10009 T10008 prep in,sensitivity
R6654 T10010 T10011 compound GBM,cells
R6655 T10011 T10009 pobj cells,in
R6656 T10012 T10001 punct .,are
R6657 T10013 T10014 nsubj WWOX,binds
R6658 T10014 T10014 ROOT binds,binds
R6659 T10015 T10014 dobj MEK,binds
R6660 T10016 T10014 punct ",",binds
R6661 T10017 T10014 cc and,binds
R6662 T10018 T10020 mark that,dissociates
R6663 T10019 T10020 nsubj PMA,dissociates
R6664 T10020 T10014 conj dissociates,binds
R6665 T10021 T10022 det this,complex
R6666 T10022 T10020 dobj complex,dissociates
R6667 T10023 T10020 prep for,dissociates
R6668 T10024 T10023 pcomp causing,for
R7633 T11213 T11214 amod appropriate,chemicals
R7634 T11214 T11224 nsubjpass chemicals,expected
R7635 T11215 T11214 punct ",",chemicals
R7636 T11216 T11217 nsubj which,break
R7637 T11217 T11214 relcl break,chemicals
R7638 T11218 T11217 advmod apart,break
R7639 T11219 T11221 det the,complex
R7640 T11220 T11221 compound WWOX/MEK,complex
R7641 T11221 T11217 dobj complex,break
R7642 T11222 T11214 punct ",",chemicals
R7643 T11223 T11224 auxpass are,expected
R7644 T11224 T11224 ROOT expected,expected
R7645 T11225 T11226 aux to,cause
R7646 T11226 T11224 xcomp cause,expected
R7647 T11227 T11229 compound GBM,death
R7648 T11228 T11229 compound cell,death
R7649 T11229 T11226 dobj death,cause
R7650 T11230 T11224 punct .,expected
R7651 T11231 T11232 amod Preliminary,studies
R7652 T11232 T11239 nsubj studies,selected
R7653 T11233 T11232 prep from,studies
R7654 T11234 T11235 poss our,screening
R7655 T11235 T11233 pobj screening,from
R7656 T11236 T11235 prep of,screening
R7657 T11237 T11236 pobj chemicals,of
R7658 T11238 T11239 aux have,selected
R7659 T11239 T11239 ROOT selected,selected
R7660 T11240 T11242 amod certain,molecules
R7661 T11241 T11242 amod small,molecules
R7662 T11242 T11239 dobj molecules,selected
R7663 T11243 T11244 nsubj that,induce
R7664 T11244 T11242 relcl induce,molecules
R7793 T11599 T11244 dobj apoptosis,induce
R7794 T11600 T11599 prep of,apoptosis
R7795 T11601 T11602 amod many,types
R7796 T11602 T11600 pobj types,of
R7797 T11603 T11602 prep of,types
R7798 T11604 T11605 compound cancer,cells
R7799 T11605 T11603 pobj cells,of
R7800 T11606 T11609 punct (,al.
R7801 T11607 T11609 compound Lu,al.
R7802 T11608 T11609 nmod et,al.
R7803 T11609 T11242 appos al.,molecules
R7804 T11610 T11609 punct ",",al.
R7805 T11611 T11609 amod unpublished,al.
R7806 T11612 T11242 punct ),molecules
R7807 T11613 T11239 punct .,selected
R7808 T11614 T11622 advmod Indeed,enhances
R7809 T11615 T11622 punct ",",enhances
R7810 T11616 T11617 amod specific,inhibition
R7811 T11617 T11622 nsubj inhibition,enhances
R7812 T11618 T11617 prep of,inhibition
R7813 T11619 T11618 pobj MEK,of
R7814 T11620 T11617 prep by,inhibition
R7815 T11621 T11620 pobj selumetinib,by
R7816 T11622 T11622 ROOT enhances,enhances
R7817 T11623 T11626 amod TMZ-induced,death
R7818 T11624 T11625 compound cancer,cell
R7819 T11625 T11626 compound cell,death
R7820 T11626 T11622 dobj death,enhances
R7821 T11627 T11626 prep in,death
R7822 T11628 T11627 pobj vivo,in
R7823 T11629 T11632 punct (,al.
R7824 T11630 T11632 compound Holt,al.
R7825 T11631 T11632 nmod et,al.
R7826 T11632 T11622 npadvmod al.,enhances
R7827 T11633 T11632 punct ",",al.
R7828 T11634 T11632 npadvmod 2012,al.
R7829 T11635 T11632 punct ),al.
R7830 T11636 T11622 punct .,enhances
R7831 T11637 T11638 compound Serum,factors
R7832 T11638 T11641 nsubjpass factors,utilized
R7833 T11639 T11641 aux can,utilized
R7834 T11640 T11641 auxpass be,utilized
R7835 T11641 T11641 ROOT utilized,utilized
R7836 T11642 T11641 prep for,utilized
R7837 T11643 T11642 pcomp blocking,for
R7838 T11644 T11645 compound cancer,growth
R7839 T11645 T11643 dobj growth,blocking
R7840 T11646 T11641 punct .,utilized
R7841 T11647 T11653 prep For,induces
R7842 T11648 T11647 pobj example,For
R7843 T11649 T11653 punct ",",induces
R7844 T11650 T11651 compound serum,complement
R7845 T11651 T11653 nsubj complement,induces
R7846 T11652 T11653 nsubj C1q,induces
R7847 T11653 T11653 ROOT induces,induces
R7848 T11654 T11653 dobj apoptosis,induces
R7849 T11655 T11654 prep of,apoptosis
R7850 T11656 T11657 compound prostate,cancer
R7851 T11657 T11655 pobj cancer,of
R7852 T11658 T11657 cc and,cancer
R7853 T11659 T11660 amod neuroblastomas,cells
R7854 T11660 T11657 conj cells,cancer
R7855 T11661 T11653 prep without,induces
R7856 T11662 T11661 pobj participation,without
R7857 T11663 T11662 prep of,participation
R7858 T11664 T11665 amod downstream,proteins
R7859 T11665 T11663 pobj proteins,of
R7860 T11666 T11662 prep in,participation
R7861 T11667 T11670 det the,pathway
R7862 T11668 T11670 amod classical,pathway
R7863 T11669 T11670 compound activation,pathway
R7864 T11670 T11666 pobj pathway,in
R7865 T11671 T11674 punct (,al.
R7866 T11672 T11674 nmod Hong,al.
R7867 T11673 T11674 nmod et,al.
R7868 T11674 T11653 parataxis al.,induces
R7869 T11675 T11674 punct ",",al.
R7870 T11676 T11674 npadvmod 2009,al.
R7871 T11677 T11674 punct ),al.
R7872 T11678 T11653 punct .,induces
R7873 T11679 T11686 prep In,activated
R7874 T11680 T11681 det this,event
R7875 T11681 T11679 pobj event,In
R7876 T11682 T11686 punct ",",activated
R7877 T11683 T11684 compound ectopic,WWOX
R7878 T11684 T11686 nsubjpass WWOX,activated
R7879 T11685 T11686 auxpass is,activated
R7880 T11686 T11686 ROOT activated,activated
R7881 T11687 T11686 prep for,activated
R7882 T11688 T11687 pcomp inducing,for
R7883 T11689 T11688 dobj apoptosis,inducing
R7884 T11690 T11686 punct .,activated
R7885 T11691 T11705 nsubj Failure,is
R7886 T11692 T11691 prep of,Failure
R7887 T11693 T11694 compound ectopic,WWOX
R7888 T11694 T11692 pobj WWOX,of
R7889 T11695 T11691 prep in,Failure
R7890 T11696 T11695 pcomp inducing,in
R7891 T11697 T11696 dobj apoptosis,inducing
R7892 T11698 T11697 prep of,apoptosis
R7893 T11699 T11700 compound glioma,cells
R7894 T11700 T11698 pobj cells,of
R7895 T11701 T11696 conj possessing,inducing
R7896 T11702 T11703 amod wild,type
R7897 T11703 T11704 compound type,p53
R7898 T11704 T11701 dobj p53,possessing
R7899 T11705 T11705 ROOT is,is
R7900 T11706 T11705 acomp unusual,is
R7901 T11707 T11710 punct (,al.
R7902 T11708 T11710 compound Chiang,al.
R7903 T11709 T11710 nmod et,al.
R7904 T11710 T11705 prep al.,is
R7905 T11711 T11710 punct ",",al.
R7906 T11712 T11710 npadvmod 2012,al.
R7907 T11713 T11710 punct ),al.
R7908 T11714 T11705 punct .,is
R7909 T11715 T11721 prep In,shown
R7910 T11716 T11717 amod most,cases
R7911 T11717 T11715 pobj cases,In
R7912 T11718 T11721 punct ",",shown
R7913 T11719 T11721 nsubj we,shown
R7914 T11720 T11721 aux have,shown
R7915 T11721 T11721 ROOT shown,shown
R7916 T11722 T11725 mark that,interacts
R7917 T11723 T11725 nsubj p53,interacts
R7918 T11724 T11725 advmod functionally,interacts
R7919 T11725 T11721 ccomp interacts,shown
R7920 T11726 T11725 prep with,interacts
R7921 T11727 T11726 pobj WWOX,with
R7922 T11728 T11725 punct ",",interacts
R7923 T11729 T11721 cc and,shown
R7924 T11730 T11731 det both,proteins
R7925 T11731 T11732 nsubj proteins,induce
R7926 T11732 T11721 conj induce,shown
R7927 T11733 T11732 dobj apoptosis,induce
R7928 T11734 T11732 prep in,induce
R7929 T11735 T11737 det a,manner
R7930 T11736 T11737 amod synergistic,manner
R7931 T11737 T11734 pobj manner,in
R7932 T11738 T11759 punct (,al.
R7933 T11739 T11741 compound Chang,al.
R7934 T11740 T11741 nmod et,al.
R7935 T11741 T11759 ccomp al.,al.
R7936 T11742 T11741 punct ",",al.
R7937 T11743 T11741 nummod 2001,al.
R7938 T11744 T11743 punct ",",2001
R7939 T11745 T11743 conj 2003,2001
R7940 T11746 T11741 punct ",",al.
R7941 T11747 T11741 appos 2005a,al.
R7942 T11748 T11749 punct ",",b
R7943 T11749 T11741 conj b,al.
R7944 T11750 T11749 punct ",",b
R7945 T11751 T11749 npadvmod 2007,b
R7946 T11752 T11751 punct ",",2007
R7947 T11753 T11751 conj 2010,2007
R7948 T11754 T11753 punct ",",2010
R7949 T11755 T11753 conj 2012,2010
R7950 T11756 T11759 punct ;,al.
R7951 T11757 T11759 compound Su,al.
R7952 T11758 T11759 nmod et,al.
R7953 T11759 T11732 parataxis al.,induce
R7954 T11760 T11759 punct ",",al.
R7955 T11761 T11759 npadvmod 2012,al.
R7956 T11762 T11759 punct ),al.
R7957 T11763 T11721 punct .,shown
R7958 T11764 T11766 det A,scenario
R7959 T11765 T11766 amod likely,scenario
R7960 T11766 T11767 nsubj scenario,is
R7961 T11767 T11767 ROOT is,is
R7962 T11768 T11779 mark that,interfere
R7963 T11769 T11770 amod p53-binding,proteins
R7964 T11770 T11779 nsubj proteins,interfere
R7965 T11771 T11770 punct ",",proteins
R7966 T11772 T11773 nsubj which,are
R7967 T11773 T11770 relcl are,proteins
R7968 T11774 T11773 acomp present,are
R7969 T11775 T11774 prep in,present
R7970 T11776 T11775 pobj GBMs,in
R7971 T11777 T11770 punct ",",proteins
R7972 T11778 T11779 aux may,interfere
R7973 T11779 T11767 ccomp interfere,is
R7974 T11780 T11779 prep with,interfere
R7975 T11781 T11783 det the,function
R7976 T11834 T11833 prep during,upregulated
R7977 T11782 T11783 amod apoptotic,function
R7978 T11835 T11837 det the,stage
R7979 T11836 T11837 amod early,stage
R7980 T11783 T11780 pobj function,with
R7981 T11837 T11834 pobj stage,during
R7982 T11838 T11837 prep of,stage
R7983 T11839 T11840 compound cancer,progression
R7984 T11840 T11838 pobj progression,of
R7985 T11841 T11844 punct (,al.
R7986 T11784 T11783 prep of,function
R7987 T11842 T11844 compound Lai,al.
R7988 T11785 T11784 pobj WWOX,of
R7989 T11843 T11844 nmod et,al.
R7990 T11844 T11837 appos al.,stage
R7991 T11786 T11785 cc and,WWOX
R7992 T11845 T11844 punct ",",al.
R7993 T11846 T11844 npadvmod 2005,al.
R7994 T11847 T11844 punct ;,al.
R7995 T11787 T11785 conj p53,WWOX
R7996 T11848 T11850 compound Chang,al.
R7997 T11849 T11850 nmod et,al.
R7998 T11850 T11833 npadvmod al.,upregulated
R7999 T11788 T11767 punct .,is
R8000 T11851 T11850 punct ",",al.
R8001 T11852 T11850 amod unpublished,al.
R8002 T11789 T11790 amod Functional,antagonism
R8003 T11853 T11833 punct ),upregulated
R8004 T11854 T11805 punct .,is
R8005 T11855 T11858 aux Do,act
R8006 T11856 T11857 det these,proteins
R8007 T11790 T11797 nsubjpass antagonism,documented
R8008 T11857 T11858 nsubj proteins,act
R8009 T11858 T11858 ROOT act,act
R8010 T11791 T11790 prep among,antagonism
R8011 T11859 T11858 advmod synergistically,act
R8012 T11860 T11858 prep in,act
R8013 T11861 T11860 pcomp blocking,in
R8014 T11862 T11863 compound cancer,progression
R8015 T11792 T11793 compound tumor,suppressors
R8016 T11863 T11861 dobj progression,blocking
R8017 T11864 T11858 cc but,act
R8018 T11865 T11858 conj lose,act
R8019 T11793 T11791 pobj suppressors,among
R8020 T11866 T11865 dobj control,lose
R8021 T11867 T11858 advmod eventually,act
R8022 T11868 T11858 punct ?,act
R8023 T11794 T11797 aux has,documented
R8024 T11869 T11873 cc Or,counteract
R8025 T11870 T11873 punct ",",counteract
R8026 T11871 T11873 aux do,counteract
R8027 T11795 T11797 neg never,documented
R8028 T11872 T11873 nsubj they,counteract
R8029 T11873 T11873 ROOT counteract,counteract
R8030 T11874 T11875 det each,other
R8031 T11796 T11797 auxpass been,documented
R8032 T11875 T11876 poss other,function
R8033 T11876 T11873 dobj function,counteract
R8034 T11877 T11873 punct ",",counteract
R8035 T11878 T11879 advmod thus,allowing
R8036 T11879 T11873 advcl allowing,counteract
R8037 T11880 T11881 compound cancer,growth
R8038 T11797 T11797 ROOT documented,documented
R8039 T11881 T11879 dobj growth,allowing
R8040 T11882 T11873 punct ?,counteract
R8041 T11798 T11797 prep in,documented
R8042 T11883 T11886 mark Whether,counteracts
R8043 T11799 T11800 det the,literature
R8044 T11884 T11886 nsubj endogenous,counteracts
R8045 T11885 T11886 nsubj WWOX,counteracts
R8046 T11886 T11893 csubj counteracts,is
R8047 T11800 T11798 pobj literature,in
R8048 T11887 T11886 prep with,counteracts
R8049 T11888 T11889 det the,function
R8050 T11889 T11887 pobj function,with
R8051 T11890 T11889 prep of,function
R8052 T11801 T11797 punct .,documented
R8053 T11891 T11892 amod endogenous,p53
R8054 T11892 T11890 pobj p53,of
R8055 T11802 T11805 advmod However,is
R8056 T11893 T11893 ROOT is,is
R8057 T11894 T11893 acomp unknown,is
R8058 T11895 T11893 cc and,is
R8059 T11803 T11805 punct ",",is
R8060 T11896 T11893 conj remains,is
R8061 T11897 T11899 aux to,established
R8062 T11898 T11899 auxpass be,established
R8063 T11804 T11805 nsubj it,is
R8064 T11899 T11896 xcomp established,remains
R8065 T11900 T11893 punct .,is
R8066 T11805 T11805 ROOT is,is
R8067 T11901 T11909 nsubj One,is
R8068 T11902 T11901 prep of,One
R8069 T11903 T11905 det the,characteristics
R8070 T11904 T11905 amod unique,characteristics
R8071 T11806 T11807 neg not,surprising
R8072 T11905 T11902 pobj characteristics,of
R8073 T11906 T11905 prep for,characteristics
R8074 T11907 T11908 amod malignant,gliomas
R8075 T11807 T11805 acomp surprising,is
R8076 T11908 T11906 pobj gliomas,for
R8077 T11909 T11909 ROOT is,is
R8078 T11910 T11912 poss their,infiltration
R8079 T11911 T11912 compound diffuse,infiltration
R8080 T11808 T11809 aux to,find
R8081 T11912 T11909 attr infiltration,is
R8082 T11913 T11912 prep into,infiltration
R8083 T11914 T11916 amod distant,tissue
R8084 T11915 T11916 compound brain,tissue
R8085 T11916 T11913 pobj tissue,into
R8086 T11917 T11909 punct .,is
R8087 T11809 T11805 xcomp find,is
R8088 T11918 T11919 compound Signal,pathways
R8089 T11919 T11934 nsubjpass pathways,believed
R8090 T11920 T11919 punct ",",pathways
R8091 T11810 T11833 mark that,upregulated
R8092 T11921 T11919 acl involving,pathways
R8093 T11922 T11921 dobj PI3K,involving
R8094 T11923 T11922 punct ",",PI3K
R8095 T11811 T11814 amod many,proteins
R8096 T11924 T11922 conj Akt,PI3K
R8097 T11925 T11924 punct ",",Akt
R8098 T11926 T11924 conj mTOR,Akt
R8099 T11812 T11814 compound tumor,proteins
R8100 T11927 T11926 punct ",",mTOR
R8101 T11928 T11926 conj NF-κB,mTOR
R8102 T11929 T11928 punct ",",NF-κB
R8103 T11930 T11928 cc and,NF-κB
R8104 T11813 T11814 compound suppressor,proteins
R8105 T11814 T11833 nsubjpass proteins,upregulated
R8106 T11815 T11814 punct ",",proteins
R8107 T11931 T11928 conj autophagy,NF-κB
R8108 T11932 T11934 punct ",",believed
R8109 T11933 T11934 auxpass are,believed
R8110 T11816 T11814 conj e.g.,proteins
R8111 T11934 T11934 ROOT believed,believed
R8112 T11935 T11936 aux to,confer
R8113 T11936 T11934 xcomp confer,believed
R8114 T11937 T11939 det these,cells
R8115 T11817 T11816 punct ",",e.g.
R8116 T11938 T11939 amod migrating,cells
R8117 T11818 T11816 conj p53,e.g.
R8118 T11939 T11936 dobj cells,confer
R8119 T11940 T11936 advmod resistant,confer
R8120 T11941 T11940 prep to,resistant
R8121 T11942 T11943 amod apoptotic,death
R8122 T11819 T11818 punct ",",p53
R8123 T11943 T11941 pobj death,to
R8124 T11944 T11947 punct (,al.
R8125 T11945 T11947 nmod Lefranc,al.
R8126 T11946 T11947 nmod et,al.
R8127 T11820 T11818 conj WWOX,p53
R8128 T11947 T11936 advmod al.,confer
R8129 T11948 T11947 punct ",",al.
R8130 T11949 T11947 npadvmod 2005,al.
R8131 T11950 T11934 punct ),believed
R8132 T11821 T11820 punct ",",WWOX
R8133 T11951 T11934 punct .,believed
R8134 T11952 T11953 compound Glioma,cells
R8135 T11953 T11954 nsubj cells,possess
R8136 T11954 T11974 ccomp possess,al.
R8137 T11955 T11954 dobj CD44,possess
R8138 T11956 T11954 prep as,possess
R8139 T11822 T11820 conj Smad4,WWOX
R8140 T11957 T11958 det a,receptor
R8141 T11958 T11956 pobj receptor,as
R8142 T11959 T11958 prep for,receptor
R8143 T11960 T11959 pcomp interacting,for
R8144 T11823 T11822 punct ",",Smad4
R8145 T11961 T11960 prep with,interacting
R8146 T11824 T11822 conj PTEN,Smad4
R8147 T11962 T11964 compound brain,hyaluronan
R8148 T11825 T11824 punct ",",PTEN
R8149 T11963 T11964 compound matrix,hyaluronan
R8150 T11964 T11961 pobj hyaluronan,with
R8151 T11826 T11824 conj PP2A,PTEN
R8152 T11965 T11968 punct (,al.
R8153 T11966 T11968 compound Murai,al.
R8154 T11967 T11968 nmod et,al.
R8155 T11827 T11826 punct ",",PP2A
R8156 T11968 T11964 appos al.,hyaluronan
R8157 T11969 T11968 punct ",",al.
R8158 T11970 T11968 npadvmod 2004,al.
R8159 T11828 T11826 cc and,PP2A
R8160 T11971 T11974 punct ;,al.
R8161 T11972 T11974 compound Yoshida,al.
R8162 T11973 T11974 nmod et,al.
R8163 T11829 T11826 conj etc.,PP2A
R8164 T11974 T11974 ROOT al.,al.
R8165 T11975 T11974 punct ",",al.
R8166 T11976 T11974 npadvmod 2012,al.
R8167 T11830 T11833 punct ",",upregulated
R8168 T11977 T11974 punct ),al.
R8169 T11978 T11974 punct ",",al.
R8170 T11831 T11833 auxpass are,upregulated
R8171 T11979 T11974 cc and,al.
R8172 T11980 T11974 conj secrete,al.
R8173 T11981 T11980 dobj hyaluronidases,secrete
R8174 T11832 T11833 advmod significantly,upregulated
R8175 T11982 T11981 cc and,hyaluronidases
R8176 T11983 T11981 conj metalloproteinases,hyaluronidases
R8177 T11984 T11985 aux to,facilitate
R8178 T11833 T11809 ccomp upregulated,find
R8179 T11985 T11980 advcl facilitate,secrete
R8180 T11986 T11987 poss their,migration
R8181 T11987 T11985 dobj migration,facilitate
R8182 T12028 T12027 dobj migration,facilitates
R8183 T11988 T11991 punct (,al.
R8184 T11989 T11991 compound Delpech,al.
R8185 T11990 T11991 nmod et,al.
R8186 T11991 T11985 npadvmod al.,facilitate
R8187 T12029 T12028 prep of,migration
R8188 T11992 T11991 punct ",",al.
R8189 T11993 T11991 npadvmod 2002,al.
R8190 T11994 T11991 punct ;,al.
R8191 T11995 T11997 compound Junker,al.
R8192 T12030 T12031 compound ovarian,cancer
R8193 T11996 T11997 compound et,al.
R8194 T11997 T11991 conj al.,al.
R8195 T11998 T11997 punct ",",al.
R8196 T12031 T12029 pobj cancer,of
R8197 T11999 T11997 appos 2003,al.
R8198 T12000 T11985 punct ;,facilitate
R8199 T12001 T12003 compound Hagemann,al.
R8200 T12032 T12031 cc and,cancer
R8201 T12002 T12003 compound et,al.
R8202 T12003 T11980 conj al.,secrete
R8203 T12004 T12003 punct ",",al.
R8204 T12033 T12034 compound osteosarcoma,cells
R8205 T12005 T12003 npadvmod 2012,al.
R8206 T12006 T12003 punct ),al.
R8207 T12007 T11974 punct .,al.
R8208 T12008 T12015 advmod Also,expected
R8209 T12034 T12031 conj cells,cancer
R8210 T12009 T12015 punct ",",expected
R8211 T12010 T12015 nsubjpass lack,expected
R8212 T12011 T12010 prep of,lack
R8213 T12035 T12028 punct (,migration
R8214 T12012 T12013 compound WWOX,expression
R8215 T12013 T12011 pobj expression,of
R8216 T12036 T12038 compound Gourley,al.
R8217 T12014 T12015 auxpass is,expected
R8218 T12015 T12015 ROOT expected,expected
R8219 T12016 T12017 aux to,enhance
R8220 T12037 T12038 nmod et,al.
R8221 T12017 T12015 xcomp enhance,expected
R8222 T12018 T12019 compound cell,migration
R8223 T12038 T12028 appos al.,migration
R8224 T12019 T12017 dobj migration,enhance
R8225 T12020 T12015 punct .,expected
R8226 T12021 T12027 prep For,facilitates
R8227 T12039 T12038 punct ",",al.
R8228 T12022 T12021 pobj example,For
R8229 T12023 T12027 punct ",",facilitates
R8230 T12024 T12027 nsubj loss,facilitates
R8231 T12040 T12038 npadvmod 2009,al.
R8232 T12025 T12024 prep of,loss
R8233 T12026 T12025 pobj WWOX,of
R8234 T12027 T12045 ccomp facilitates,al.
R8235 T12041 T12045 punct ;,al.
R8236 T12042 T12043 compound Del,Mare
R8237 T12043 T12045 compound Mare,al.
R8238 T12125 T12131 prep In,migrate
R8239 T12044 T12045 nmod et,al.
R8240 T12126 T12125 pobj contrast,In
R8241 T12127 T12131 punct ",",migrate
R8242 T12128 T12130 amod wild,cells
R8243 T12045 T12045 ROOT al.,al.
R8244 T12129 T12130 compound type,cells
R8245 T12130 T12131 nsubj cells,migrate
R8246 T12131 T12131 ROOT migrate,migrate
R8247 T12046 T12045 punct ",",al.
R8248 T12132 T12131 advmod collectively,migrate
R8249 T12133 T12136 punct (,al.
R8250 T12047 T12045 npadvmod 2011,al.
R8251 T12134 T12136 compound Chou,al.
R8252 T12135 T12136 nmod et,al.
R8253 T12136 T12131 parataxis al.,migrate
R8254 T12137 T12136 punct ",",al.
R8255 T12048 T12045 punct ),al.
R8256 T12138 T12136 amod unpublished,al.
R8257 T12139 T12136 punct ),al.
R8258 T12140 T12131 punct .,migrate
R8259 T12049 T12045 punct .,al.
R8260 T12141 T12147 mark While,anchored
R8261 T12142 T12143 det a,portion
R8262 T12143 T12147 nsubjpass portion,anchored
R8263 T12050 T12051 amod Ectopic,expression
R8264 T12144 T12143 prep of,portion
R8265 T12145 T12144 pobj WWOX,of
R8266 T12146 T12147 auxpass is,anchored
R8267 T12147 T12155 advcl anchored,lose
R8268 T12051 T12051 ROOT expression,expression
R8269 T12148 T12147 prep on,anchored
R8270 T12052 T12051 prep of,expression
R8271 T12149 T12151 det the,membrane/cytoskeleton
R8272 T12150 T12151 compound cell,membrane/cytoskeleton
R8273 T12151 T12148 pobj membrane/cytoskeleton,on
R8274 T12053 T12052 pobj TIAF1,of
R8275 T12152 T12155 punct ",",lose
R8276 T12054 T12057 punct (,factor
R8277 T12153 T12154 amod WWOX-negative,cells
R8278 T12154 T12155 nsubj cells,lose
R8279 T12055 T12057 amod TGF-β-induced,factor
R8280 T12155 T12155 ROOT lose,lose
R8281 T12156 T12155 dobj recognition,lose
R8282 T12157 T12155 prep by,lose
R8283 T12158 T12160 amod parental,cells
R8284 T12159 T12160 amod WWOX-positive,cells
R8285 T12056 T12057 amod antiapoptotic,factor
R8286 T12160 T12157 pobj cells,by
R8287 T12161 T12155 punct ",",lose
R8288 T12162 T12155 cc and,lose
R8289 T12163 T12164 nsubj this,increases
R8290 T12057 T12051 appos factor,expression
R8291 T12164 T12155 conj increases,lose
R8292 T12165 T12166 det the,mobility
R8293 T12166 T12164 dobj mobility,increases
R8294 T12058 T12051 punct ),expression
R8295 T12167 T12166 prep of,mobility
R8296 T12168 T12169 amod WWOX-negative,cells
R8297 T12169 T12167 pobj cells,of
R8298 T12059 T12051 punct ",",expression
R8299 T12170 T12171 aux to,move
R8300 T12171 T12164 xcomp move,increases
R8301 T12172 T12171 advmod away,move
R8302 T12060 T12051 conj p53,expression
R8303 T12173 T12172 prep from,away
R8304 T12174 T12176 det the,cells
R8305 T12175 T12176 amod WWOX-positive,cells
R8306 T12061 T12060 punct ",",p53
R8307 T12176 T12173 pobj cells,from
R8308 T12177 T12164 punct .,increases
R8309 T12062 T12051 cc and,expression
R8310 T12063 T12064 nsubj WWOX,suppresses
R8311 T12178 T12183 advmod Conceivably,migrate
R8312 T12064 T12064 ROOT suppresses,suppresses
R8313 T12179 T12183 punct ",",migrate
R8314 T12180 T12182 amod WWOX-negative,cells
R8315 T12065 T12066 amod anchorage-independent,growth
R8316 T12066 T12064 dobj growth,suppresses
R8317 T12067 T12066 cc and,growth
R8318 T12181 T12182 compound glioma,cells
R8319 T12182 T12183 nsubj cells,migrate
R8320 T12068 T12069 compound cell,migration
R8321 T12183 T12183 ROOT migrate,migrate
R8322 T12184 T12183 advmod individually,migrate
R8323 T12185 T12183 cc and,migrate
R8324 T12186 T12183 conj turn,migrate
R8325 T12069 T12066 conj migration,growth
R8326 T12187 T12186 advmod away,turn
R8327 T12070 T12064 cc and,suppresses
R8328 T12188 T12187 prep from,away
R8329 T12189 T12191 amod WWOX-expressing,cells
R8330 T12190 T12191 compound brain,cells
R8331 T12191 T12188 pobj cells,from
R8332 T12071 T12064 conj causes,suppresses
R8333 T12192 T12186 prep to,turn
R8334 T12193 T12196 amod low,areas
R8335 T12194 T12196 compound WWOX,areas
R8336 T12072 T12071 dobj apoptosis,causes
R8337 T12195 T12196 compound expression,areas
R8338 T12073 T12071 prep in,causes
R8339 T12196 T12192 pobj areas,to
R8340 T12197 T12183 punct .,migrate
R8341 T12198 T12208 advmod Apparently,account
R8342 T12074 T12075 compound cancer,cells
R8343 T12199 T12208 punct ",",account
R8344 T12200 T12202 det the,behavior
R8345 T12201 T12202 amod migratory,behavior
R8346 T12075 T12073 pobj cells,in
R8347 T12202 T12208 nsubj behavior,account
R8348 T12203 T12202 prep of,behavior
R8349 T12076 T12079 punct (,al.
R8350 T12204 T12206 amod WWOX-negative,cells
R8351 T12205 T12206 compound glioma,cells
R8352 T12206 T12203 pobj cells,of
R8353 T12077 T12079 compound Chang,al.
R8354 T12207 T12208 aux may,account
R8355 T12208 T12208 ROOT account,account
R8356 T12209 T12208 prep for,account
R8357 T12078 T12079 nmod et,al.
R8358 T12210 T12212 det the,invasion
R8359 T12211 T12212 compound diffuse,invasion
R8360 T12212 T12209 pobj invasion,for
R8361 T12213 T12212 prep into,invasion
R8362 T12079 T12051 appos al.,expression
R8363 T12214 T12216 amod distant,tissue
R8364 T12215 T12216 compound brain,tissue
R8365 T12216 T12213 pobj tissue,into
R8366 T12080 T12079 punct ",",al.
R8367 T12217 T12212 punct (,invasion
R8368 T12218 T12220 compound Chou,al.
R8369 T12219 T12220 nmod et,al.
R8370 T12081 T12079 npadvmod 2012,al.
R8371 T12220 T12212 appos al.,invasion
R8372 T12221 T12220 punct ",",al.
R8373 T12082 T12079 punct ),al.
R8374 T12083 T12051 punct .,expression
R8375 T12222 T12220 amod unpublished,al.
R8376 T12084 T12085 nsubj We,believe
R8377 T12223 T12212 punct ),invasion
R8378 T12224 T12208 punct .,account
R8379 T12225 T12226 amod Metabolic,alterations
R8380 T12085 T12085 ROOT believe,believe
R8381 T12226 T12229 nsubjpass alterations,shown
R8382 T12086 T12095 mark that,migrate
R8383 T12227 T12229 aux have,shown
R8384 T12228 T12229 auxpass been,shown
R8385 T12229 T12229 ROOT shown,shown
R8386 T12230 T12229 prep in,shown
R8387 T12231 T12233 compound Wwox,mice
R8388 T12087 T12088 amod glioma,cells
R8389 T12232 T12233 compound knockout,mice
R8390 T12088 T12095 nsubj cells,migrate
R8391 T12233 T12230 pobj mice,in
R8392 T12234 T12233 punct ",",mice
R8393 T12235 T12233 prep including,mice
R8394 T12089 T12088 punct ",",cells
R8395 T12236 T12237 amod postnatal,lethality
R8396 T12237 T12235 pobj lethality,including
R8397 T12238 T12237 punct ",",lethality
R8398 T12090 T12088 prep with,cells
R8399 T12239 T12241 compound bone,defects
R8400 T12240 T12241 compound metabolism,defects
R8401 T12241 T12237 conj defects,lethality
R8402 T12091 T12093 compound stem,properties
R8403 T12242 T12241 punct ",",defects
R8404 T12243 T12241 conj ataxia,defects
R8405 T12244 T12243 punct ",",ataxia
R8406 T12092 T12093 compound cell-like,properties
R8407 T12245 T12243 conj steroidogenesis,ataxia
R8408 T12246 T12245 punct ",",steroidogenesis
R8409 T12247 T12245 cc and,steroidogenesis
R8410 T12093 T12090 pobj properties,with
R8411 T12248 T12245 conj generation,steroidogenesis
R8412 T12249 T12245 prep of,steroidogenesis
R8413 T12094 T12095 punct ",",migrate
R8414 T12250 T12249 pobj osteosarcomas,of
R8415 T12251 T12250 punct (,osteosarcomas
R8416 T12252 T12253 compound Del,Mare
R8417 T12095 T12085 ccomp migrate,believe
R8418 T12253 T12255 nmod Mare,al.
R8419 T12254 T12255 nmod et,al.
R8420 T12255 T12250 appos al.,osteosarcomas
R8421 T12096 T12095 advmod individually,migrate
R8422 T12256 T12255 punct ",",al.
R8423 T12257 T12255 npadvmod 2011,al.
R8424 T12258 T12250 punct ;,osteosarcomas
R8425 T12097 T12098 advmod rather,than
R8426 T12259 T12261 compound Salah,al.
R8427 T12260 T12261 nmod et,al.
R8428 T12261 T12250 conj al.,osteosarcomas
R8429 T12098 T12096 cc than,individually
R8430 T12262 T12261 punct ",",al.
R8431 T12263 T12261 npadvmod 2012,al.
R8432 T12099 T12096 conj collectively,individually
R8433 T12264 T12245 punct ),steroidogenesis
R8434 T12265 T12229 punct .,shown
R8435 T12266 T12273 prep In,shown
R8436 T12267 T12269 det a,model
R8437 T12268 T12269 compound Drosophila,model
R8438 T12269 T12266 pobj model,In
R8439 T12270 T12273 punct ",",shown
R8440 T12100 T12085 punct .,believe
R8441 T12271 T12273 nsubjpass Wwox,shown
R8442 T12272 T12273 auxpass is,shown
R8443 T12273 T12273 ROOT shown,shown
R8444 T12101 T12102 det This,assumption
R8445 T12102 T12104 nsubjpass assumption,based
R8446 T12274 T12275 aux to,participate
R8447 T12275 T12273 xcomp participate,shown
R8448 T12103 T12104 auxpass is,based
R8449 T12276 T12275 prep in,participate
R8450 T12277 T12276 pobj pathways,in
R8451 T12104 T12104 ROOT based,based
R8452 T12105 T12104 prep upon,based
R8453 T12278 T12277 acl involving,pathways
R8454 T12106 T12107 poss our,observations
R8455 T12279 T12280 amod aerobic,metabolism
R8456 T12280 T12278 dobj metabolism,involving
R8457 T12281 T12280 cc and,metabolism
R8458 T12107 T12105 pobj observations,upon
R8459 T12282 T12283 amod oxidative,stress
R8460 T12283 T12280 conj stress,metabolism
R8461 T12108 T12120 mark that,migrate
R8462 T12284 T12283 prep for,stress
R8463 T12285 T12284 pobj generation,for
R8464 T12286 T12285 prep of,generation
R8465 T12109 T12113 compound mouse,cells
R8466 T12287 T12286 pobj ROS,of
R8467 T12288 T12287 punct (,ROS
R8468 T12289 T12290 compound et,al.
R8469 T12110 T12113 compound Wwox,cells
R8470 T12290 T12287 appos al.,ROS
R8471 T12291 T12290 punct ",",al.
R8472 T12111 T12112 compound gene,knockout
R8473 T12292 T12290 npadvmod 2011,al.
R8474 T12293 T12287 punct ),ROS
R8475 T12294 T12273 punct .,shown
R8476 T12112 T12113 compound knockout,cells
R8477 T12295 T12303 prep Under,induces
R8478 T12296 T12297 compound UV,stress
R8479 T12297 T12295 pobj stress,Under
R8480 T12113 T12120 nsubj cells,migrate
R8481 T12298 T12303 punct ",",induces
R8482 T12299 T12302 amod functional,expression
R8483 T12114 T12113 punct (,cells
R8484 T12300 T12302 compound Wwox,expression
R8485 T12301 T12302 compound gene,expression
R8486 T12302 T12303 nsubj expression,induces
R8487 T12303 T12303 ROOT induces,induces
R8488 T12304 T12305 compound ROS,production
R8489 T12305 T12303 dobj production,induces
R8490 T12115 T12120 nsubj e.g.,migrate
R8491 T12306 T12305 prep in,production
R8492 T12307 T12306 pobj Drosophila,in
R8493 T12308 T12303 punct .,induces
R8494 T12309 T12310 compound Cancer,cells
R8495 T12116 T12118 punct ",",fibroblasts
R8496 T12117 T12118 amod embryonic,fibroblasts
R8497 T12310 T12312 nsubjpass cells,known
R8498 T12118 T12115 appos fibroblasts,e.g.
R8499 T12311 T12312 auxpass are,known
R8500 T12312 T12312 ROOT known,known
R8501 T12313 T12315 aux to,utilize
R8502 T12119 T12115 punct ),e.g.
R8503 T12314 T12315 advmod overly,utilize
R8504 T12315 T12312 xcomp utilize,known
R8505 T12316 T12315 dobj glycolysis,utilize
R8506 T12120 T12104 ccomp migrate,based
R8507 T12317 T12315 prep for,utilize
R8508 T12318 T12319 compound growth,advantage
R8509 T12121 T12120 advmod individually,migrate
R8510 T12122 T12121 cc and,individually
R8511 T12123 T12121 conj aggressively,individually
R8512 T12319 T12317 pobj advantage,for
R8513 T12124 T12104 punct .,based
R8514 T12320 T12322 det the,Warburg
R8515 T12321 T12322 amod so-called,Warburg
R8516 T12322 T12315 dobj Warburg,utilize
R8517 T12375 T12373 conj WWOX,p53
R8518 T12323 T12326 punct (,al.
R8519 T12376 T12369 prep in,role
R8520 T12324 T12326 nmod Moncada,al.
R8521 T12325 T12326 nmod et,al.
R8522 T12326 T12322 nummod al.,Warburg
R8523 T12377 T12376 pcomp regulating,in
R8524 T12327 T12326 punct ",",al.
R8525 T12328 T12326 npadvmod 2012,al.
R8526 T12329 T12326 punct ),al.
R8527 T12378 T12379 compound TMZ,sensitivity
R8528 T12330 T12312 punct .,known
R8529 T12331 T12334 advmod Conceivably,is
R8530 T12332 T12334 punct ",",is
R8531 T12333 T12334 nsubj WWOX,is
R8532 T12379 T12377 dobj sensitivity,regulating
R8533 T12334 T12334 ROOT is,is
R8534 T12335 T12334 acomp likely,is
R8535 T12336 T12337 aux to,override
R8536 T12337 T12335 xcomp override,likely
R8537 T12338 T12339 compound glucose,consumption
R8538 T12380 T12379 prep in,sensitivity
R8539 T12339 T12337 dobj consumption,override
R8540 T12340 T12337 prep in,override
R8541 T12341 T12342 compound cancer,cells
R8542 T12342 T12340 pobj cells,in
R8543 T12381 T12382 compound GBM,cells
R8544 T12343 T12334 cc and,is
R8545 T12344 T12345 compound exerts,generation
R8546 T12345 T12349 nsubj generation,curb
R8547 T12382 T12380 pobj cells,in
R8548 T12346 T12345 prep of,generation
R8549 T12347 T12346 pobj ROS,of
R8550 T12348 T12349 aux to,curb
R8551 T12383 T12366 punct .,discussed
R8552 T12349 T12334 conj curb,is
R8553 T12350 T12353 det the,growth
R8554 T12351 T12352 compound cancer,cell
R8555 T12384 T12386 nsubj We,shown
R8556 T12385 T12386 aux have,shown
R8557 T12352 T12353 compound cell,growth
R8558 T12386 T12386 ROOT shown,shown
R8559 T12353 T12349 dobj growth,curb
R8560 T12354 T12353 cc and,growth
R8561 T12387 T12388 det the,role
R8562 T12355 T12353 conj invasion,growth
R8563 T12356 T12334 punct .,is
R8564 T12357 T12366 prep In,discussed
R8565 T12358 T12357 pobj summary,In
R8566 T12388 T12386 dobj role,shown
R8567 T12359 T12366 punct ",",discussed
R8568 T12360 T12366 prep in,discussed
R8569 T12389 T12388 prep of,role
R8570 T12361 T12363 det this,article
R8571 T12362 T12363 compound perspective,article
R8572 T12363 T12360 pobj article,in
R8573 T12390 T12389 pobj WWOX,of
R8574 T12364 T12366 nsubj we,discussed
R8575 T12365 T12366 aux have,discussed
R8576 T12366 T12366 ROOT discussed,discussed
R8577 T12391 T12388 prep in,role
R8578 T12367 T12369 det the,role
R8579 T12368 T12369 amod potential,role
R8580 T12392 T12391 pcomp controlling,in
R8581 T12393 T12394 compound cell,migration
R8582 T12394 T12392 dobj migration,controlling
R8583 T12369 T12366 dobj role,discussed
R8584 T12395 T12394 cc and,migration
R8585 T12370 T12369 prep of,role
R8586 T12371 T12372 compound tumor,suppressors
R8587 T12372 T12373 compound suppressors,p53
R8588 T12373 T12370 pobj p53,of
R8589 T12374 T12373 cc and,p53
R8590 T12396 T12397 amod metabolic,alterations
R8591 T12397 T12394 conj alterations,migration
R8592 T12398 T12386 punct ",",shown
R8593 T12399 T12386 cc and,shown
R8594 T12400 T12386 conj discussed,shown
R8595 T12401 T12402 det the,effects
R8596 T12402 T12400 dobj effects,discussed
R8597 T12403 T12402 prep of,effects
R8598 T12404 T12405 compound WWOX,deficiency
R8599 T12405 T12403 pobj deficiency,of
R8600 T12406 T12405 cc and,deficiency
R8601 T12407 T12408 compound TMZ,resistance
R8602 T12408 T12405 conj resistance,deficiency
R8603 T12409 T12400 prep in,discussed
R8604 T12410 T12411 compound cancer,cells
R8605 T12411 T12409 pobj cells,in
R8606 T12412 T12386 punct .,shown
R8656 T12540 T12541 compound Ming-Fu,Chiang
R8657 T12541 T12545 nsubj Chiang,wrote
R8658 T12542 T12541 cc and,Chiang
R8659 T12543 T12544 compound Chun-I,Sze
R8660 T12544 T12541 conj Sze,Chiang
R8661 T12545 T12554 ccomp wrote,wrote
R8662 T12546 T12547 det the,sections
R8663 T12547 T12545 dobj sections,wrote
R8664 T12548 T12547 acl dealing,sections
R8665 T12549 T12548 prep with,dealing
R8666 T12550 T12549 pobj TMZ,with
R8667 T12551 T12554 punct ;,wrote
R8668 T12552 T12553 compound Pei-Yi,Chou
R8669 T12553 T12554 nsubj Chou,wrote
R8670 T12554 T12554 ROOT wrote,wrote
R8671 T12555 T12557 det the,sections
R8672 T12556 T12557 compound review,sections
R8673 T12557 T12554 dobj sections,wrote
R8674 T12558 T12557 prep for,sections
R8675 T12559 T12558 pobj p53,for
R8676 T12560 T12559 cc and,p53
R8677 T12561 T12559 conj WWOX,p53
R8678 T12562 T12561 cc and,WWOX
R8679 T12563 T12564 amod designed,graphs
R8680 T12564 T12561 conj graphs,WWOX
R8681 T12565 T12568 punct ;,managed
R8682 T12566 T12567 compound Wan-Jen,Wang
R8683 T12567 T12568 nsubj Wang,managed
R8684 T12568 T12573 ccomp managed,conceived
R8685 T12569 T12568 dobj citations,managed
R8686 T12570 T12573 punct ;,conceived
R8687 T12571 T12572 compound Nan-Shan,Chang
R8688 T12572 T12573 nsubj Chang,conceived
R8689 T12573 T12554 ccomp conceived,wrote
R8690 T12574 T12573 dobj ideas,conceived
R8691 T12575 T12573 punct ",",conceived
R8692 T12576 T12573 conj wrote,conceived
R8693 T12577 T12576 cc and,wrote
R8694 T12578 T12579 advmod thoroughly,revised
R8695 T12579 T12576 conj revised,wrote
R8696 T12580 T12581 det the,manuscript
R8697 T12581 T12579 dobj manuscript,revised
R8698 T12582 T12579 punct ",",revised
R8699 T12583 T12579 cc and,revised
R8700 T12584 T12579 conj discussed,revised
R8701 T12585 T12584 prep with,discussed
R8702 T12586 T12585 pobj coauthors,with
R8703 T12587 T12554 punct .,wrote
R8734 T12618 T12619 det The,authors
R8735 T12619 T12620 nsubj authors,declare
R8736 T12620 T12620 ROOT declare,declare
R8737 T12621 T12625 mark that,conducted
R8738 T12622 T12623 det the,research
R8739 T12623 T12625 nsubjpass research,conducted
R8740 T12624 T12625 auxpass was,conducted
R8741 T12625 T12620 ccomp conducted,declare
R8742 T12626 T12625 prep in,conducted
R8743 T12627 T12628 det the,absence
R8744 T12628 T12626 pobj absence,in
R8745 T12629 T12628 prep of,absence
R8746 T12630 T12631 det any,commercial
R8747 T12631 T12634 amod commercial,relationships
R8748 T12632 T12631 cc or,commercial
R8749 T12633 T12631 conj financial,commercial
R8750 T12634 T12629 pobj relationships,of
R8751 T12635 T12638 nsubjpass that,construed
R8752 T12636 T12638 aux could,construed
R8753 T12637 T12638 auxpass be,construed
R8754 T12638 T12634 relcl construed,relationships
R8755 T12639 T12638 prep as,construed
R8756 T12640 T12642 det a,conflict
R8757 T12641 T12642 amod potential,conflict
R8758 T12642 T12639 pobj conflict,as
R8759 T12643 T12642 prep of,conflict
R8760 T12644 T12643 pobj interest,of
R8761 T12645 T12620 punct .,declare
R8927 T12940 T13959 punct .,is
R8928 T12941 T12947 prep In,binds
R8929 T12942 T12941 pobj response,In
R8930 T12943 T12942 prep to,response
R8931 T12944 T12943 pobj TGF-β1,to
R8932 T12945 T12947 punct ",",binds
R8933 T12946 T12947 nsubj WWOX,binds
R8934 T12947 T12947 ROOT binds,binds
R8935 T12948 T12947 dobj Hyal-2,binds
R8936 T12949 T12948 cc and,Hyal-2
R8937 T12950 T12948 conj forms,Hyal-2
R8938 T12951 T12952 det a,complex
R8939 T12952 T12950 dobj complex,forms
R8940 T12953 T12950 punct ",",forms
R8941 T12954 T12947 advcl followed,binds
R8942 T12955 T12954 agent by,followed
R8943 T12956 T12955 pcomp relocating,by
R8944 T12957 T12956 prep to,relocating
R8945 T12958 T12959 det the,nucleus
R8946 T12959 T12957 pobj nucleus,to
R8947 T12960 T12956 cc and,relocating
R8948 T12961 T12956 conj enhancing,relocating
R8949 T12962 T12965 det the,activity
R8950 T12963 T12965 amod SMAD-driven,activity
R8951 T12964 T12965 compound promoter,activity
R8952 T12965 T12961 dobj activity,enhancing
R8953 T12966 T12947 punct .,binds
R8954 T12967 T12967 ROOT Ack1,Ack1
R8955 T12968 T12967 punct ",",Ack1
R8956 T12969 T12974 amod activated,Hyal-2
R8957 T12970 T12971 amod Cdc42-associated,kinase
R8958 T12971 T12969 dobj kinase,activated
R8959 T12972 T12971 nummod 1,kinase
R8960 T12973 T12969 punct ;,activated
R8961 T12974 T12967 conj Hyal-2,Ack1
R8962 T12975 T12974 punct ",",Hyal-2
R8963 T12976 T12979 nmod hyaluronoglucosaminidase,CKI
R8964 T12977 T12976 nummod 2,hyaluronoglucosaminidase
R8965 T12978 T12979 punct ;,CKI
R8966 T12979 T12974 conj CKI,Hyal-2
R8967 T12980 T12979 punct ",",CKI
R8968 T12981 T12982 compound casein,kinase
R8969 T12982 T12979 appos kinase,CKI
R8970 T12983 T12979 punct ;,CKI
R8971 T12984 T12979 conj GSK,CKI
R8972 T12985 T12984 punct ",",GSK
R8973 T12986 T12988 nmod glycogen,kinase
R8974 T12987 T12988 compound synthase,kinase
R8975 T12988 T12984 appos kinase,GSK
R8976 T12989 T12984 punct ;,GSK
R8977 T12990 T12984 conj PKA,GSK
R8978 T12991 T12990 punct ",",PKA
R8979 T12992 T12994 compound protein,A.
R8980 T12993 T12994 compound kinase,A.
R8981 T12994 T12990 appos A.,PKA
R9379 T13557 T13558 amod Schematic,diagrams
R9380 T13558 T13558 ROOT diagrams,diagrams
R9381 T13559 T13558 prep of,diagrams
R9382 T13560 T13561 compound WWOX,structure
R9383 T13561 T13559 pobj structure,of
R9384 T13562 T13558 cc and,diagrams
R9385 T13563 T13564 poss its,role
R9386 T13564 T13558 conj role,diagrams
R9387 T13565 T13564 prep in,role
R9388 T13566 T13565 pcomp signaling,in
R9389 T13567 T13558 punct .,diagrams
R9390 T13568 T13569 nsubj WWOX,contains
R9391 T13569 T13569 ROOT contains,contains
R9392 T13570 T13573 nummod two,domains
R9393 T13571 T13573 amod N-terminal,domains
R9394 T13572 T13573 compound WW,domains
R9395 T13573 T13569 dobj domains,contains
R9396 T13574 T13573 punct ",",domains
R9397 T13575 T13579 det a,dehydrogenase/reductase
R9398 T13576 T13579 amod C-terminal,dehydrogenase/reductase
R9399 T13577 T13579 compound short-chain,dehydrogenase/reductase
R9400 T13578 T13579 compound alcohol,dehydrogenase/reductase
R9401 T13579 T13573 appos dehydrogenase/reductase,domains
R9402 T13580 T13581 punct (,SDR
R9403 T13581 T13579 appos SDR,dehydrogenase/reductase
R9404 T13582 T13581 punct ),SDR
R9405 T13583 T13579 conj domain,dehydrogenase/reductase
R9406 T13584 T13583 punct ",",domain
R9407 T13585 T13583 cc and,domain
R9408 T13586 T13588 det a,region
R9409 T13587 T13588 amod D3,region
R9410 T13588 T13583 conj region,domain
R9411 T13589 T13569 punct .,contains
R9412 T13590 T13593 det A,signal
R9425 T13603 T13606 punct (,al.
R9426 T13604 T13606 compound Chang,al.
R9427 T13605 T13606 nmod et,al.
R9428 T13606 T13776 ccomp al.,al.
R9429 T13607 T13606 punct ",",al.
R9430 T13608 T13606 appos 2003,al.
R9431 T13609 T13608 punct ",",2003
R9432 T13610 T13608 conj 2007,2003
R9433 T13611 T13776 punct ;,al.
R9434 T13612 T13613 compound Del,Mare
R9435 T13613 T13615 compound Mare,al.
R9436 T13614 T13615 nmod et,al.
R9437 T13615 T13776 ccomp al.,al.
R9438 T13616 T13615 punct ",",al.
R9439 T13617 T13615 npadvmod 2011,al.
R9440 T13618 T13615 punct ;,al.
R9441 T13619 T13621 compound Salah,al.
R9442 T13620 T13621 nmod et,al.
R9443 T13621 T13615 conj al.,al.
R9444 T13622 T13621 punct ",",al.
R9445 T13623 T13621 npadvmod 2012,al.
R9446 T13624 T13776 punct ;,al.
R9447 T13625 T13776 compound Su,al.
R9448 T13626 T13776 nmod et,al.
R9492 T13776 T13776 ROOT al.,al.
R9493 T13777 T13776 punct ",",al.
R9494 T13778 T13776 npadvmod 2012,al.
R9495 T13779 T13780 punct ;,reviews
R9496 T13780 T13776 appos reviews,al.
R9497 T13781 T13780 punct ),reviews
R9498 T13782 T13776 punct .,al.
R9499 T13783 T13785 det The,domain
R9500 T13784 T13785 compound SDR,domain
R9501 T13785 T13786 nsubj domain,possesses
R9502 T13786 T13786 ROOT possesses,possesses
R9503 T13787 T13789 det a,region
R9504 T13788 T13789 amod mitochondria-binding,region
R9505 T13789 T13786 dobj region,possesses
R9506 T13790 T13786 punct .,possesses
R9507 T13791 T13792 expl There,are
R9508 T13792 T13792 ROOT are,are
R9509 T13793 T13797 nummod two,sites
R9510 T13794 T13797 amod conserved,sites
R9511 T13795 T13797 amod tyrosine,sites
R9512 T13796 T13797 compound phosphorylation,sites
R9513 T13797 T13792 attr sites,are
R9514 T13798 T13797 punct ",",sites
R9515 T13799 T13797 appos Tyr33,sites
R9516 T13800 T13799 cc and,Tyr33
R9517 T13801 T13799 conj Tyr287,Tyr33
R9518 T13802 T13792 punct .,are
R9519 T13803 T13805 amod Other,sites
R9520 T13804 T13805 compound phosphorylation,sites
R9521 T13805 T13811 nsubj sites,are
R9522 T13806 T13805 acl predicted,sites
R9523 T13807 T13806 agent by,predicted
R9524 T13808 T13810 nmod NetPhos,Server
R9525 T13809 T13810 nummod 2.0,Server
R9526 T13810 T13807 pobj Server,by
R9527 T13811 T13811 ROOT are,are
R9528 T13812 T13811 attr Tyr6,are
R9529 T13813 T13812 punct ",",Tyr6
R9530 T13814 T13812 conj Thr12,Tyr6
R9531 T13815 T13814 punct ",",Thr12
R9532 T13816 T13814 conj Ser14,Thr12
R9547 T13831 T13832 nsubj WWOX,is
R9548 T13832 T13833 auxpass is,phosphorylated
R9549 T13833 T13833 ROOT phosphorylated,phosphorylated
R9550 T13834 T13833 prep in,phosphorylated
R9551 T13835 T13834 pobj Tyr33,in
R9552 T13836 T13833 cc and,phosphorylated
R9553 T13837 T13833 conj binds,phosphorylated
R9554 T13838 T13837 dobj p53,binds
R9555 T13839 T13833 punct .,phosphorylated
R9556 T13840 T13842 det The,complex
R9557 T13841 T13842 amod WWOX/p53,complex
R9558 T13842 T13844 nsubj complex,translocates
R9559 T13843 T13844 advmod then,translocates
R9560 T13844 T13844 ROOT translocates,translocates
R9561 T13845 T13846 aux to,mitochondria
R9562 T13846 T13844 xcomp mitochondria,translocates
R9563 T13847 T13846 cc or,mitochondria
R9564 T13848 T13846 conj nucleus,mitochondria
R9565 T13849 T13850 aux to,induce
R9566 T13850 T13848 advcl induce,nucleus
R9567 T13851 T13850 dobj apoptosis,induce
R9568 T13852 T13844 punct .,translocates
R9569 T13853 T13855 nsubj WWOX,binds
R9570 T13854 T13855 advmod also,binds
R9571 T13855 T13855 ROOT binds,binds
R9572 T13856 T13859 compound PPxY,factors
R9573 T13857 T13858 compound motif-containing,transcription
R9574 T13858 T13859 compound transcription,factors
R9575 T13859 T13855 dobj factors,binds
R9576 T13860 T13859 punct ",",factors
R9577 T13861 T13862 amod such,as
R9578 T13862 T13859 prep as,factors
R9579 T13863 T13862 pobj RUNX2,as
R9580 T13864 T13863 punct ",",RUNX2
R9581 T13865 T13863 conj c-Jun,RUNX2
R9582 T13866 T13865 punct ",",c-Jun
R9583 T13867 T13865 cc and,c-Jun
R9584 T13868 T13865 conj ERBB4,c-Jun
R9585 T13869 T13859 punct ",",factors
R9586 T13870 T13855 prep via,binds
R9587 T13871 T13874 poss its,domain
R9588 T13872 T13874 amod first,domain
R9589 T13873 T13874 compound WW,domain
R9590 T13874 T13870 pobj domain,via
R9591 T13875 T13855 punct ",",binds
R9592 T13876 T13855 cc and,binds
R9593 T13877 T13879 det the,blocks
R9594 T13878 T13879 amod binding,blocks
R9595 T13879 T13855 conj blocks,binds
R9596 T13880 T13881 det the,activity
R9597 T13881 T13879 dobj activity,blocks
R9598 T13882 T13881 prep of,activity
R9599 T13883 T13884 det these,proteins
R9600 T13884 T13882 pobj proteins,of
R9601 T13885 T13879 prep by,blocks
R9602 T13886 T13885 pcomp retaining,by
R9603 T13887 T13886 dobj them,retaining
R9604 T13888 T13886 prep in,retaining
R9605 T13889 T13890 det the,cytoplasm
R9606 T13890 T13888 pobj cytoplasm,in
R9607 T13891 T13855 punct .,binds
R9608 T13892 T13893 nsubj WWOX,binds
R9609 T13893 T13893 ROOT binds,binds
R9610 T13894 T13893 dobj Tau,binds
R9611 T13895 T13893 prep via,binds
R9612 T13896 T13898 poss its,domain
R9613 T13897 T13898 compound SDR,domain
R9614 T13898 T13895 pobj domain,via
R9615 T13899 T13893 punct .,binds
R9616 T13900 T13901 nsubj WWOX,participates
R9617 T13901 T13901 ROOT participates,participates
R9618 T13902 T13901 prep in,participates
R9619 T13903 T13908 det the,pathway
R9620 T13904 T13908 nmod Wnt,pathway
R9621 T13905 T13908 nmod /,pathway
R9622 T13906 T13908 amod β-catenin,pathway
R9623 T13907 T13908 compound signal,pathway
R9624 T13908 T13902 pobj pathway,in
R9625 T13909 T13901 prep by,participates
R9626 T13910 T13911 amod binding,Dvl
R9627 T13911 T13909 pobj Dvl,by
R9628 T13912 T13901 cc and,participates
R9629 T13913 T13901 conj inhibiting,participates
R9630 T13914 T13916 poss its,import
R9631 T13915 T13916 amod nuclear,import
R9632 T13916 T13913 dobj import,inhibiting
R9633 T13917 T13901 punct .,participates
R9634 T13918 T13919 compound Phorbol,ester
R9635 T13919 T13920 nsubj ester,stimulates
R9636 T13920 T13920 ROOT stimulates,stimulates
R9637 T13921 T13922 det the,dissociation
R9638 T13922 T13920 dobj dissociation,stimulates
R9639 T13923 T13922 prep of,dissociation
R9640 T13924 T13925 compound MEK/WWOX,complex
R9641 T13925 T13923 pobj complex,of
R9642 T13926 T13922 prep in,dissociation
R9643 T13927 T13928 compound Jurkat,T
R9644 T13928 T13929 compound T,cell
R9645 T13929 T13926 pobj cell,in
R9646 T13930 T13920 punct ",",stimulates
R9647 T13931 T13920 cc and,stimulates
R9648 T13932 T13935 det the,translocates
R9649 T13933 T13935 amod released,translocates
R9650 T13934 T13935 compound WWOX,translocates
R9651 T13935 T13920 conj translocates,stimulates
R9652 T13936 T13935 prep to,translocates
R9653 T13937 T13938 det the,mitochondria
R9654 T13938 T13936 pobj mitochondria,to
R9655 T13939 T13935 prep for,translocates
R9656 T13940 T13939 pcomp causing,for
R9657 T13941 T13942 compound cell,death
R9658 T13942 T13940 dobj death,causing
R9659 T13943 T13920 punct .,stimulates
R9660 T13944 T13946 nsubjpass WWOX,recruited
R9661 T13945 T13946 auxpass is,recruited
R9662 T13946 T13946 ROOT recruited,recruited
R9663 T13947 T13946 prep to,recruited
R9664 T13948 T13950 det the,area
R9665 T13949 T13950 compound membrane,area
R9666 T13950 T13947 pobj area,to
R9667 T13951 T13946 agent by,recruited
R9668 T13952 T13951 pobj association,by
R9669 T13953 T13952 prep with,association
R9670 T13954 T13953 pobj Hyal-2,with
R9671 T13955 T13954 cc and,Hyal-2
R9672 T13956 T13954 conj phospho-Ezrin,Hyal-2
R9673 T13957 T13946 punct .,recruited
R9674 T13958 T13959 nsubj Hyal-2,is
R9675 T13959 T13959 ROOT is,is
R9676 T13960 T13962 det an,receptor
R9677 T13961 T13962 amod alternative,receptor
R9678 T13962 T13959 attr receptor,is
R9679 T13963 T13962 prep for,receptor
R9680 T13964 T13963 pobj TGF-β1,for
R9951 T14525 T14525 ROOT p53,p53
R9952 T14526 T14525 cc and,p53
R9953 T14527 T14525 conj WWOX,p53
R9954 T14528 T14527 prep in,WWOX
R9955 T14529 T14531 compound GBM,apoptosis
R9956 T14530 T14531 compound cell,apoptosis
R9957 T14531 T14528 pobj apoptosis,in
R9958 T14532 T14525 punct .,p53
R9959 T14533 T14538 punct (,possesses
R9960 T14534 T14537 det A,p53
R9961 T14535 T14537 punct ),p53
R9962 T14536 T14537 amod Full-length,p53
R9963 T14537 T14538 nsubj p53,possesses
R9964 T14538 T14538 ROOT possesses,possesses
R9965 T14539 T14543 nummod two,domains
R9966 T14540 T14543 amod N-terminal,domains
R9967 T14541 T14543 amod transactivation,domains
R9968 T14542 T14543 amod acidic,domains
R9969 T14543 T14538 dobj domains,possesses
R9970 T14544 T14543 punct ",",domains
R9971 T14545 T14547 det a,domain
R9972 T14546 T14547 amod proline-rich,domain
R9973 T14547 T14543 appos domain,domains
R9974 T14548 T14547 punct ",",domain
R9975 T14549 T14552 det a,region
R9976 T14550 T14552 amod central,region
R9977 T14551 T14552 amod DNA-binding,region
R9978 T14552 T14547 conj region,domain
R9979 T14553 T14547 punct ",",domain
R9980 T14554 T14547 cc and,domain
R9981 T14555 T14557 det a,domain
R9982 T14556 T14557 amod C-terminal,domain
R9983 T14557 T14547 conj domain,domain
R9984 T14558 T14557 punct ",",domain
R9985 T14559 T14557 acl containing,domain
R9986 T14560 T14563 det a,signal
R9987 T14561 T14562 amod nuclear,localization
R9988 T14562 T14563 compound localization,signal
R9989 T14563 T14559 dobj signal,containing
R9990 T14564 T14563 punct ",",signal
R9991 T14565 T14567 det an,domain
R9992 T14566 T14567 compound oligomerization,domain
R9993 T14567 T14563 conj domain,signal
R9994 T14568 T14567 punct ",",domain
R9995 T14569 T14567 cc and,domain
R9996 T14570 T14572 det a,region
R9997 T14571 T14572 amod basic,region
R9998 T14572 T14567 conj region,domain
R9999 T14573 T14538 punct .,possesses
R10000 T14574 T14576 amod N-terminal,mutants
R10001 T14575 T14576 compound deletion,mutants
R10002 T14576 T14581 nsubjpass mutants,shown
R10003 T14577 T14576 prep of,mutants
R10004 T14578 T14577 pobj p53,of
R10005 T14579 T14581 auxpass are,shown
R10006 T14580 T14581 advmod also,shown
R10007 T14581 T14581 ROOT shown,shown
R10008 T14582 T14581 punct .,shown
R10009 T14583 T14584 punct (,B
R10010 T14584 T14584 ROOT B,B
R10011 T14585 T14584 punct ),B
R10012 T14586 T14588 nummod Three,scenarios
R10013 T14587 T14588 amod likely,scenarios
R10014 T14588 T14590 nsubjpass scenarios,proposed
R10015 T14589 T14590 auxpass are,proposed
R10016 T14590 T14590 ROOT proposed,proposed
R10017 T14591 T14590 prep for,proposed
R10018 T14592 T14591 pobj WWOX,for
R10019 T14593 T14592 cc and,WWOX
R10020 T14594 T14592 conj p53,WWOX
R10021 T14595 T14596 aux to,regulate
R10022 T14596 T14590 advcl regulate,proposed
R10023 T14597 T14599 compound GBM,death
R10024 T14598 T14599 compound cell,death
R10025 T14599 T14596 dobj death,regulate
R10026 T14600 T14590 punct .,proposed
R10027 T14601 T14605 advmod First,fails
R10028 T14602 T14605 punct ",",fails
R10029 T14603 T14604 compound ectopic,WWOX
R10030 T14604 T14605 nsubj WWOX,fails
R10031 T14605 T14605 ROOT fails,fails
R10032 T14606 T14607 aux to,induce
R10033 T14607 T14605 xcomp induce,fails
R10034 T14608 T14607 dobj apoptosis,induce
R10035 T14609 T14608 prep of,apoptosis
R10036 T14610 T14611 compound GBM,cells
R10037 T14611 T14609 pobj cells,of
R10038 T14612 T14611 acl expressing,cells
R10039 T14613 T14616 amod endogenous,p53
R10040 T14614 T14615 amod wild,type
R10041 T14615 T14616 compound type,p53
R10042 T14616 T14612 dobj p53,expressing
R10043 T14617 T14605 punct .,fails
R10044 T14618 T14619 nsubj It,appears
R10045 T14619 T14619 ROOT appears,appears
R10046 T14620 T14623 mark that,binds
R10047 T14621 T14622 compound ectopic,WWOX
R10048 T14622 T14623 compound WWOX,binds
R10049 T14623 T14632 nsubj binds,nullify
R10050 T14624 T14623 cc and,binds
R10051 T14625 T14626 advmod functionally,antagonizes
R10052 T14626 T14623 conj antagonizes,binds
R10053 T14627 T14626 dobj p53,antagonizes
R10054 T14628 T14626 punct ",",antagonizes
R10055 T14629 T14626 cc and,antagonizes
R10056 T14630 T14631 det both,proteins
R10057 T14631 T14626 conj proteins,antagonizes
R10058 T14632 T14619 ccomp nullify,appears
R10059 T14633 T14634 det each,other
R10060 T14634 T14635 poss other,function
R10061 T14635 T14632 dobj function,nullify
R10062 T14636 T14632 prep in,nullify
R10063 T14637 T14636 pcomp inducing,in
R10064 T14638 T14637 dobj apoptosis,inducing
R10065 T14639 T14619 punct .,appears
R10066 T14640 T14652 advmod Second,expected
R10067 T14641 T14652 punct ",",expected
R10068 T14642 T14644 det no,interactions
R10069 T14643 T14644 amod physical,interactions
R10070 T14644 T14652 nsubjpass interactions,expected
R10071 T14645 T14644 prep between,interactions
R10072 T14646 T14648 amod mutant,proteins
R10073 T14647 T14648 compound p53,proteins
R10074 T14648 T14645 pobj proteins,between
R10075 T14649 T14648 cc and,proteins
R10076 T14650 T14648 conj WWOX,proteins
R10077 T14651 T14652 auxpass are,expected
R10078 T14652 T14652 ROOT expected,expected
R10079 T14653 T14652 prep in,expected
R10080 T14654 T14655 compound GBM,cells
R10081 T14655 T14653 pobj cells,in
R10082 T14656 T14652 punct .,expected
R10083 T14657 T14661 advmod Thus,induce
R10084 T14658 T14661 punct ",",induce
R10085 T14659 T14661 nsubj ectopic,induce
R10086 T14660 T14661 nsubj WWOX,induce
R10087 T14661 T14661 ROOT induce,induce
R10088 T14662 T14661 dobj apoptosis,induce
R10089 T14663 T14662 prep in,apoptosis
R10090 T14664 T14666 amod mutant,cells
R10091 T14665 T14666 amod p53-expressing,cells
R10092 T14666 T14663 pobj cells,in
R10093 T14667 T14661 punct .,induce
R10094 T14668 T14675 advmod Finally,is
R10095 T14669 T14675 punct ",",is
R10096 T14670 T14672 mark whether,binds
R10097 T14671 T14672 nsubj WWOX,binds
R10098 T14672 T14675 csubj binds,is
R10099 T14673 T14674 compound p53,isoforms
R10100 T14674 T14672 dobj isoforms,binds
R10101 T14675 T14675 ROOT is,is
R10102 T14676 T14675 acomp unknown,is
R10103 T14677 T14675 punct .,is
R10104 T14678 T14692 advmod Also,remains
R10105 T14679 T14692 punct ",",remains
R10106 T14680 T14692 mark whether,remains
R10107 T14681 T14683 amod ectopic,induction
R10108 T14682 T14683 compound WWOX,induction
R10109 T14683 T14692 nsubj induction,remains
R10110 T14684 T14683 prep of,induction
R10111 T14685 T14684 pobj apoptosis,of
R10112 T14686 T14683 prep in,induction
R10113 T14687 T14688 compound GBM,cells
R10114 T14688 T14686 pobj cells,in
R10115 T14689 T14692 csubj expressing,remains
R10116 T14690 T14691 compound p53,isoforms
R10117 T14691 T14689 dobj isoforms,expressing
R10118 T14692 T14692 ROOT remains,remains
R10119 T14693 T14695 aux to,established
R10120 T14694 T14695 auxpass be,established
R10121 T14695 T14692 xcomp established,remains
R10122 T14696 T14692 punct .,remains
R10123 T14697 T14700 nmod TAD,domain
R10124 T14698 T14700 punct ",",domain
R10125 T14699 T14700 amod transactivation,domain
R10126 T14700 T14700 ROOT domain,domain
R10127 T14701 T14700 punct ;,domain
R10128 T14702 T14705 nmod PrD,domain
R10129 T14703 T14705 punct ",",domain
R10130 T14704 T14705 compound proline,domain
R10131 T14705 T14700 appos domain,domain
R10132 T14706 T14700 punct ;,domain
R10133 T14707 T14711 nmod NLS,signal
R10134 T14708 T14707 punct ",",NLS
R10135 T14709 T14710 amod nuclear,localization
R10136 T14710 T14711 compound localization,signal
R10137 T14711 T14711 ROOT signal,signal
R10138 T14712 T14711 punct ;,signal
R10139 T14713 T14716 nmod OD,domain
R10140 T14714 T14716 punct ",",domain
R10141 T14715 T14716 amod oligomerization,domain
R10142 T14716 T14700 conj domain,domain
R10143 T14717 T14716 punct ;,domain
R10144 T14718 T14721 nmod BR,region
R10145 T14719 T14721 punct ",",region
R10146 T14720 T14721 amod basic,region
R10147 T14721 T14716 npadvmod region,domain
R10148 T14722 T14700 punct .,domain
R5152 T7302 T7300 npadvmod 1998,al.
R5153 T7303 T7292 punct ),expression
R5154 T7304 T7282 punct ",",plays
R5155 T7305 T7282 conj collagens,plays
R5156 T7306 T7305 dobj IIα1,collagens
R5157 T7307 T7306 cc and,IIα1
R5158 T7308 T7306 conj VIα1,IIα1
R5159 T7309 T7312 punct (,al.
R5160 T7310 T7312 compound Sun,al.
R5161 T7311 T7312 nmod et,al.
R5162 T7312 T7308 parataxis al.,VIα1
R5163 T7313 T7312 punct ",",al.
R5164 T7314 T7312 npadvmod 1999,al.
R5165 T7315 T7312 punct ),al.
R9413 T13591 T13592 amod nuclear,localization
R9414 T13592 T13593 compound localization,signal
R9415 T13593 T13597 nsubj signal,is
R9416 T13594 T13593 punct (,signal
R9417 T13595 T13593 appos NLS,signal
R9418 T13596 T13593 punct ),signal
R9419 T13597 T13776 ccomp is,al.
R9420 T13598 T13597 prep in,is
R9421 T13599 T13598 prep between,in
R9422 T13600 T13602 det the,domains
R9423 T13601 T13602 compound WW,domains
R9424 T13602 T13599 pobj domains,between
R9533 T13817 T13816 punct ",",Ser14
R9534 T13818 T13816 conj Tyr61,Ser14
R9535 T13819 T13818 punct ",",Tyr61
R9536 T13820 T13818 conj Tyr293,Tyr61
R9537 T13821 T13820 punct ",",Tyr293
R9538 T13822 T13820 cc and,Tyr293
R9539 T13823 T13820 conj Thr3B3,Tyr293
R9540 T13824 T13823 punct ",",Thr3B3
R9541 T13825 T13811 advmod respectively,are
R9542 T13826 T13811 punct .,are
R9543 T13827 T13833 prep Upon,phosphorylated
R9544 T13828 T13829 compound stress,stimulation
R9545 T13829 T13827 pobj stimulation,Upon
R9546 T13830 T13833 punct ",",phosphorylated
R7665 T11245 T10024 dobj apoptosis,causing
R7666 T11246 T11245 prep of,apoptosis
R7667 T11247 T11249 compound T,cells
R7668 T11248 T11249 compound leukemia,cells
R7669 T11249 T11246 pobj cells,of
R7670 T11250 T11253 punct (,al.
R7671 T11251 T11253 compound Lin,al.
R7672 T11252 T11253 nmod et,al.
R7673 T11253 T11245 appos al.,apoptosis
R7674 T11254 T11253 punct ",",al.
R7675 T11255 T11253 npadvmod 2011,al.
R7676 T11256 T11253 punct ),al.
R7677 T11257 T10014 punct .,binds
R7678 T11258 T11224 advmod Thus,expected
R7679 T11259 T11224 punct ",",expected

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue Negation Speculation
T529 17-21 Protein denotes WWOX
T546 26-29 Protein denotes p53
T11515 19695-19709 Protein denotes endogenous p53
T14786 14185-14230 Gene_expression denotes GBM cells expressing endogenous wild type p53
T14785 14248-14266 Binding denotes ectopic WWOX binds
T14784 14554-14564 Binding denotes WWOX binds
T14783 13720-13723 Protein denotes p53
T14782 14296-14299 Protein denotes p53
T14781 14704-14708 Entity denotes TAD,
T14780 13890-13909 Entity denotes a C-terminal domain
T14779 13786-13855 Entity denotes two N-terminal transactivation acidic domains, a proline-rich domain,
T14778 13728-13754 Protein denotes WWOX in GBM cell apoptosis
T14777 14554-14558 Protein denotes WWOX
T14776 14612-14616 Protein denotes WWOX
T14775 14704-14752 Entity denotes TAD, transactivation domain; PrD, proline domain
T14774 14458-14467 Entity denotes GBM cells
T14773 14733-14737 Protein denotes PrD,
T14772 14031-14034 Protein denotes p53
T14771 14305-14318 Protein denotes both proteins
T14770 14792-14832 Protein denotes oligomerization domain; BR, basic region
T14769 14185-14230 Entity denotes GBM cells expressing endogenous wild type p53
T14768 13760-13775 Protein denotes Full-length p53
T14767 14104-14107 Protein denotes p53
T14766 14206-14230 Protein denotes endogenous wild type p53
T14765 14469-14487 Protein denotes Thus, ectopic WWOX
T14764 13890-13909 Entity denotes a C-terminal domain
T14762 14143-14155 Protein denotes ectopic WWOX
T14761 13760-13775 Protein denotes Full-length p53
T14760 14643-14676 Entity denotes GBM cells expressing p53 isoforms
T14759 14816-14819 Protein denotes BR,
T14758 14664-14667 Protein denotes p53
T14757 14704-14752 Entity denotes TAD, transactivation domain; PrD, proline domain
T14756 14792-14832 Entity denotes oligomerization domain; BR, basic region
T14755 14000-14034 Entity denotes N-terminal deletion mutants of p53
T14754 14248-14260 Protein denotes ectopic WWOX
T14753 14565-14577 Protein denotes p53 isoforms
T14752 13953-13978 Entity denotes an oligomerization domain
T14751 14437-14441 Protein denotes WWOX
T14750 13736-13754 Entity denotes GBM cell apoptosis
T14749 14704-14752 Entity denotes TAD, transactivation domain; PrD, proline domain
T14748 14413-14432 Protein denotes mutant p53 proteins
T14747 14420-14423 Protein denotes p53
T14746 13786-13855 Entity denotes two N-terminal transactivation acidic domains, a proline-rich domain,
T14745 13953-13978 Protein denotes an oligomerization domain
T14744 13835-13847 Protein denotes proline-rich
T14743 14095-14099 Protein denotes WWOX
T14742 13833-13854 Entity denotes a proline-rich domain
T14763 14515-14518 Protein denotes p53
T13691 7978-7983 Entity denotes Tyr33
T13690 8235-8247 Entity denotes mitochondria
T13689 8378-8398 Entity denotes its first WW domain,
T13688 8193-8213 Entity denotes The WWOX/p53 complex
T13687 9151-9157 Protein denotes casein
T13775 7936-7976 Binding denotes conserved tyrosine phosphorylation sites
T13774 8941-8958 Binding denotes WWOX binds Hyal-2
T13773 8489-8522 Binding denotes WWOX binds Tau via its SDR domain
T13772 8829-8870 Binding denotes association with Hyal-2 and phospho-Ezrin
T13771 8581-8592 Binding denotes binding Dvl
T13770 8146-8177 Phosphorylation denotes WWOX is phosphorylated in Tyr33
T13769 8712-8729 Regulation denotes the released WWOX
T13768 8146-8191 Binding denotes WWOX is phosphorylated in Tyr33 and binds p53
T13767 8628-8706 Positive_regulation denotes Phorbol ester stimulates the dissociation of MEK/WWOX complex in Jurkat T cell
T13766 7996-8023 Entity denotes Other phosphorylation sites
T13765 8073-8078 Entity denotes Ser14
T13764 9151-9195 Protein denotes casein kinase; GSK, glycogen synthase kinase
T13763 8296-8299 Protein denotes PPx
T13762 7988-7994 Entity denotes Tyr287
T13761 8512-8515 Protein denotes SDR
T13760 7533-7537 Protein denotes WWOX
T13759 8474-8487 Entity denotes the cytoplasm
T13758 8670-8706 Entity denotes of MEK/WWOX complex in Jurkat T cell
T13757 8677-8681 Protein denotes WWOX
T13756 7946-7954 Entity denotes tyrosine
T13755 8628-8641 Entity denotes Phorbol ester
T13754 7641-7686 Entity denotes alcohol dehydrogenase/reductase (SDR) domain,
T13753 8857-8870 Protein denotes phospho-Ezrin
T13752 8746-8785 Entity denotes the mitochondria for causing cell death
T13751 7589-7628 Entity denotes two N-terminal WW domains, a C-terminal
T13750 9067-9150 Protein denotes Ack1, activated Cdc42-associated kinase 1; Hyal-2, hyaluronoglucosaminidase 2; CKI,
T13749 8500-8503 Protein denotes Tau
T13748 8693-8706 Entity denotes Jurkat T cell
T13747 8508-8522 Entity denotes its SDR domain
T13746 8628-8635 Entity denotes Phorbol
T13745 8897-8905 Protein denotes receptor
T13744 8545-8577 Protein denotes the Wnt/β-catenin signal pathway
T13743 7870-7873 Protein denotes SDR
T13742 8910-8916 Protein denotes TGF-β1
T13741 8872-8878 Protein denotes Hyal-2
T13740 8670-8706 Entity denotes of MEK/WWOX complex in Jurkat T cell
T13739 8188-8191 Protein denotes p53
T13738 9151-9195 Protein denotes casein kinase; GSK, glycogen synthase kinase
T13737 8952-8958 Protein denotes Hyal-2
T13736 8280-8284 Protein denotes WWOX
T13735 8787-8791 Protein denotes WWOX
T13734 9118-9149 Protein denotes hyaluronoglucosaminidase 2; CKI
T13733 8066-8071 Entity denotes Thr12
T13732 7649-7678 Protein denotes dehydrogenase/reductase (SDR)
T13731 8172-8177 Entity denotes Tyr33
T13730 8553-8562 Protein denotes β-catenin
T13729 9151-9195 Protein denotes casein kinase; GSK, glycogen synthase kinase
T13728 7796-7810 Protein denotes Del Mare et al
T13727 8296-8300 Entity denotes PPxY
T13726 8087-8093 Entity denotes Tyr293
T13725 9067-9150 Protein denotes Ack1, activated Cdc42-associated kinase 1; Hyal-2, hyaluronoglucosaminidase 2; CKI,
T13724 9048-9056 Entity denotes promoter
T13723 8060-8064 Entity denotes Tyr6
T13722 7936-7976 Entity denotes conserved tyrosine phosphorylation sites
T13721 8202-8205 Protein denotes p53
T13720 7575-7579 Protein denotes WWOX
T13719 8933-8979 Protein denotes TGF-β1, WWOX binds Hyal-2 and forms a complex,
T13718 8524-8528 Protein denotes WWOX
T13717 8318-8373 Protein denotes transcription factors, such as RUNX2, c-Jun, and ERBB4,
T13716 9197-9218 Protein denotes PKA, protein kinase A
T13715 7674-7677 Protein denotes SDR
T13714 8941-8945 Protein denotes WWOX
T13713 9067-9072 Protein denotes Ack1,
T13712 7796-7810 Entity denotes Del Mare et al
T13711 7589-7603 Entity denotes two N-terminal
T13710 8251-8258 Entity denotes nucleus
T13709 8969-8978 Entity denotes a complex
T13708 9006-9017 Entity denotes the nucleus
T13707 7770-7781 Entity denotes Chang et al
T13706 8146-8150 Protein denotes WWOX
T13705 8589-8592 Protein denotes Dvl
T13704 8367-8372 Protein denotes ERBB4
T13703 8846-8852 Protein denotes Hyal-2
T13702 7866-7880 Entity denotes The SDR domain
T13701 8193-8213 Protein denotes The WWOX/p53 complex
T13700 8712-8729 Protein denotes the released WWOX
T13699 8489-8493 Protein denotes WWOX
T13698 7754-7768 Entity denotes the WW domains
T13697 8812-8820 Entity denotes membrane
T13696 7693-7695 Entity denotes D3
T13695 8356-8362 Protein denotes c-Jun,
T13694 7589-7628 Entity denotes two N-terminal WW domains, a C-terminal
T13693 8435-8452 Protein denotes of these proteins
T13692 8080-8085 Entity denotes Tyr61
T12539 22721-22729 Entity denotes with TMZ
T12538 22773-22776 Protein denotes p53
T12537 22781-22785 Protein denotes WWOX
T11598 18794-18864 Binding denotes In most cases, we have shown that p53 functionally interacts with WWOX
T11597 21918-21935 Gene_expression denotes generation of ROS
T11596 18608-18671 Positive_regulation denotes In this event, ectopic WWOX is activated for inducing apoptosis
T11595 17843-17858 Binding denotes WWOX binds MEK,
T11594 22255-22316 Gene_expression denotes generation of ROS to curb the cancer cell growth and invasion
T11593 21398-21423 Gene_expression denotes low WWOX expression areas
T11592 20317-20335 Gene_expression denotes of WWOX expression
T11591 20511-20538 Gene_expression denotes Ectopic expression of TIAF1
T11590 20540-20553 Protein denotes TGF-β-induced
T11589 17774-17777 Protein denotes p53
T11588 20445-20463 Entity denotes osteosarcoma cells
T11587 20881-20885 Protein denotes gene
T11586 20189-20207 Protein denotes metalloproteinases
T11585 21159-21187 Protein denotes parental WWOX-positive cells
T11584 17685-17689 Protein denotes WWOX
T11583 20674-20686 Entity denotes cancer cells
T11582 21988-21992 Protein denotes Wwox
T11581 18623-18635 Protein denotes ectopic WWOX
T11580 20530-20538 Protein denotes of TIAF1
T11579 21756-21767 Protein denotes Del Mare et
T11578 19909-19914 Protein denotes NF-κB
T11577 19474-19482 Protein denotes proteins
T11576 21463-21467 Protein denotes WWOX
T11575 18192-18207 Entity denotes of cancer cells
T11574 20393-20400 Protein denotes of WWOX
T11573 18015-18018 Entity denotes MEK
T11572 18722-18734 Entity denotes glioma cells
T11571 17863-17871 Entity denotes that PMA
T11570 17832-17841 Entity denotes GBM cells
T11569 17762-17766 Protein denotes WWOX
T11568 21300-21304 Protein denotes WWOX
T11567 18269-18283 Entity denotes by selumetinib
T11566 20725-20770 Entity denotes glioma cells, with stem cell-like properties,
T11565 22398-22419 Protein denotes tumor suppressors p53
T11564 18108-18117 Entity denotes chemicals
T11563 21224-21228 Protein denotes WWOX
T11562 22017-22045 Protein denotes ROS production in Drosophila
T11561 21622-21641 Protein denotes Wwox knockout mice,
T11560 21087-21118 Entity denotes the cell membrane/cytoskeleton,
T11559 20320-20324 Protein denotes WWOX
T11558 22610-22613 Entity denotes TMZ
T11557 18262-18268 Entity denotes of MEK
T11556 18746-18759 Protein denotes wild type p53
T11555 21124-21138 Entity denotes negative cells
T11554 22231-22243 Entity denotes cancer cells
T11553 18828-18831 Protein denotes p53
T11552 20029-20041 Entity denotes Glioma cells
T11551 18681-18696 Protein denotes of ectopic WWOX
T11550 17854-17858 Entity denotes MEK,
T11549 19018-19034 Protein denotes that p53-binding
T11548 20983-20998 Entity denotes wild type cells
T11547 19954-19975 Entity denotes these migrating cells
T11546 20870-20930 Entity denotes mouse Wwox gene knockout cells (e.g., embryonic fibroblasts)
T11545 22208-22227 Entity denotes glucose consumption
T11544 19265-19320 Protein denotes many tumor suppressor proteins, e.g., p53, WWOX, Smad4,
T11543 22496-22503 Protein denotes of WWOX
T11542 19892-19896 Protein denotes PI3K
T11541 17698-17701 Entity denotes TMZ
T11540 21402-21406 Protein denotes WWOX
T11539 17813-17816 Entity denotes TMZ
T11538 22628-22640 Entity denotes cancer cells
T11537 18528-18550 Protein denotes of downstream proteins
T11536 21929-21935 Protein denotes of ROS
T11535 19646-19661 Protein denotes endogenous WWOX
T11534 19903-19907 Protein denotes mTOR
T11533 19419-19428 Entity denotes Lai et al
T11532 20096-20128 Entity denotes matrix hyaluronan (Murai et al.,
T11531 17741-17766 Protein denotes Binding proteins for WWOX
T11530 18006-18026 Entity denotes the WWOX/MEK complex
T11529 17922-17938 Entity denotes T leukemia cells
T11528 21087-21118 Entity denotes the cell membrane/cytoskeleton,
T11527 17843-17847 Protein denotes WWOX
T11526 20487-20498 Protein denotes Del Mare et
T11525 18926-18937 Entity denotes Chang et al
T11524 18870-18883 Protein denotes both proteins
T11523 20744-20753 Entity denotes stem cell
T11522 20170-20184 Entity denotes hyaluronidases
T11521 19303-19313 Protein denotes p53, WWOX,
T11520 19865-19930 Entity denotes Signal pathways, involving PI3K, Akt, mTOR, NF-κB, and autophagy,
T11519 21266-21270 Protein denotes WWOX
T11518 20058-20095 Protein denotes a receptor for interacting with brain
T11517 20876-20880 Protein denotes Wwox
T11516 21823-21827 Protein denotes Wwox
T11514 22462-22471 Entity denotes GBM cells
T11513 22443-22446 Entity denotes TMZ
T11512 20586-20590 Protein denotes WWOX
T11511 19321-19341 Protein denotes PTEN, PP2A, and etc.
T11510 18855-18864 Protein denotes with WWOX
T11509 19035-19070 Protein denotes proteins, which are present in GBMs
T11508 20050-20054 Protein denotes CD44
T11507 20115-20126 Entity denotes Murai et al
T11506 19308-19312 Protein denotes WWOX
T11505 17959-18005 Entity denotes Thus, appropriate chemicals, which break apart
T11504 21262-21285 Entity denotes the WWOX-positive cells
T11503 22047-22059 Entity denotes Cancer cells
T11502 20908-20929 Entity denotes embryonic fibroblasts
T11501 19303-19319 Protein denotes p53, WWOX, Smad4
T11500 17940-17943 Entity denotes Lin
T11499 18465-18505 Entity denotes prostate cancer and neuroblastomas cells
T11498 19898-19901 Protein denotes Akt
T11497 19117-19121 Protein denotes WWOX
T11496 21372-21394 Entity denotes expressing brain cells
T11495 21064-21071 Protein denotes of WWOX
T11494 22181-22185 Protein denotes WWOX
T11493 18006-18026 Protein denotes the WWOX/MEK complex
T11492 22424-22428 Protein denotes WWOX
T11491 20239-20252 Entity denotes Delpech et al
T11490 21119-21123 Protein denotes WWOX
T11489 17884-17896 Entity denotes this complex
T11488 21229-21243 Entity denotes negative cells
T11487 22266-22272 Protein denotes of ROS
T11486 20577-20581 Protein denotes p53,
T11485 21622-21626 Protein denotes Wwox
T11484 22590-22594 Protein denotes WWOX
T11483 19126-19129 Protein denotes p53
T11482 21367-21371 Protein denotes WWOX
T11481 21305-21326 Entity denotes negative glioma cells
T11480 21468-21489 Entity denotes negative glioma cells
T11479 18123-18207 Entity denotes selected certain small molecules that induce apoptosis of many types of cancer cells
T9179 17035-17049 Positive_regulation denotes Activated WWOX
T9178 17463-17520 Binding denotes Mutant p53 proteins cannot bind ectopic WWOX in GBM cells true
T9177 16274-16297 Gene_expression denotes Altered WWOX expression
T9176 17211-17244 Binding denotes binding of this protein with WWOX
T9175 16325-16347 Negative_regulation denotes downregulation of WWOX
T9174 16468-16486 Positive_regulation denotes overexpressed WWOX
T9173 16468-16486 Gene_expression denotes overexpressed WWOX
T9172 17035-17096 Binding denotes Activated WWOX binds wild type p53 with Ser46 phosphorylation
T9171 16274-16297 Regulation denotes Altered WWOX expression
T9170 16139-16152 Protein denotes wild type p53
T9169 16468-16486 Protein denotes overexpressed WWOX
T9168 17056-17069 Protein denotes wild type p53
T9167 17495-17507 Protein denotes ectopic WWOX
T9166 17035-17049 Protein denotes Activated WWOX
T9165 17240-17244 Protein denotes WWOX
T9164 16632-16644 Protein denotes ectopic WWOX
T9163 17075-17080 Entity denotes Ser46
T9162 15961-15973 Entity denotes glioma cells
T9161 16028-16033 Entity denotes et al
T9160 16224-16227 Entity denotes TMZ
T9159 16753-16779 Entity denotes a mitochondria-independent
T9158 16064-16086 Protein denotes Loss of functional p53
T9157 16117-16129 Entity denotes glioma cells
T9156 15944-15947 Entity denotes TMZ
T9155 16004-16009 Entity denotes et al
T9154 16394-16402 Entity denotes promoter
T9153 16282-16286 Protein denotes WWOX
T9152 17292-17302 Entity denotes GBM cells,
T9151 16784-16805 Protein denotes caspase-3-independent
T9150 17029-17033 Protein denotes WWOX
T9149 17203-17209 Protein denotes Δ40p53
T9148 16167-16170 Entity denotes TMZ
T9147 16508-16534 Entity denotes glioblastoma U373-MG cells
T9146 17326-17347 Protein denotes ectopic WWOX proteins
T9145 16664-16695 Entity denotes U87-MG expressing wild type p53
T9144 16682-16695 Protein denotes wild type p53
T9143 16205-16216 Protein denotes p53 mutants
T9142 16545-16555 Protein denotes mutant p53
T9141 16110-16113 Entity denotes TMZ
T9140 17608-17611 Protein denotes p53
T9139 16704-16708 Entity denotes TMZ,
T9138 16927-16954 Entity denotes of human glioblastoma cells
T9137 16582-16585 Entity denotes DNA
T9136 17191-17199 Entity denotes of Ser46
T9135 17219-17244 Protein denotes of this protein with WWOX
T9134 17334-17338 Protein denotes WWOX
T9133 17308-17321 Protein denotes wild type p53
T9132 17013-17024 Protein denotes p53 mutants
T9131 17470-17473 Protein denotes p53
T9130 17526-17530 Protein denotes WWOX
T9129 17568-17572 Protein denotes WWOX
T9128 15852-15863 Protein denotes p53 mutants
T9127 17511-17520 Entity denotes GBM cells
T9126 17463-17482 Protein denotes Mutant p53 proteins
T9125 16508-16534 Entity denotes glioblastoma U373-MG cells
T9124 16340-16347 Protein denotes of WWOX
T9123 16709-16713 Protein denotes WWOX
T8259 15471-15504 Gene_expression denotes co-expression of p53 with Δ133p53
T8258 15272-15332 Localization denotes p53γ and Δ133p53β are localized in the nucleus and cytoplasm
T8257 15272-15332 Localization denotes p53γ and Δ133p53β are localized in the nucleus and cytoplasm
T8256 15596-15628 Regulation denotes gene expression in p53-dependent
T8255 15334-15395 Localization denotes Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005)
T8254 14906-14957 Binding denotes alternative mRNA splicing, multiple gene promoters,
T8253 15678-15724 Gene_expression denotes Co-expression of Δ133p53β or Δ133p53γ with p53
T8252 15678-15724 Gene_expression denotes Co-expression of Δ133p53β or Δ133p53γ with p53
T8251 15678-15760 Regulation denotes Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional true
T8250 15678-15760 Regulation denotes Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional true
T8249 15563-15645 Regulation denotes Δ133p53 differentially regulates gene expression in p53-dependent and -independent
T8248 15471-15515 Negative_regulation denotes co-expression of p53 with Δ133p53 suppresses
T8247 15485-15491 Protein denotes of p53
T8246 15424-15428 Protein denotes p53β
T8245 15615-15628 Protein denotes p53-dependent
T8244 15027-15030 Protein denotes Ray
T8243 15088-15103 Protein denotes of p53 isoforms
T8242 15439-15451 Protein denotes p53-mediated
T8241 14933-14956 Entity denotes multiple gene promoters
T8240 15356-15395 Entity denotes in the cytoplasm (Bourdon et al., 2005)
T8239 15191-15195 Protein denotes p53β
T8238 15281-15289 Protein denotes Δ133p53β
T8237 15161-15176 Protein denotes Full-length p53
T8236 14874-14877 Protein denotes p53
T8235 15220-15232 Entity denotes the nucleus,
T8234 15307-15318 Entity denotes the nucleus
T8233 15272-15276 Protein denotes p53γ
T8232 15781-15794 Entity denotes Bax promoters
T8231 15721-15724 Protein denotes p53
T8230 15261-15270 Entity denotes cytoplasm
T8229 15416-15419 Protein denotes p53
T8228 15563-15570 Protein denotes Δ133p53
T8227 15773-15776 Protein denotes p21
T8226 15695-15703 Protein denotes Δ133p53β
T8225 15516-15519 Protein denotes p53
T8224 15741-15744 Protein denotes p53
T8223 15178-15185 Protein denotes Δ133p53
T8222 15334-15395 Protein denotes Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005)
T8221 15161-15176 Protein denotes Full-length p53
T8220 15497-15504 Protein denotes Δ133p53
T8219 15781-15784 Protein denotes Bax
T8218 14933-14956 Protein denotes multiple gene promoters
T8217 15707-15715 Protein denotes Δ133p53γ
T8216 14918-14922 Protein denotes mRNA
T8215 15323-15332 Entity denotes cytoplasm
T7375 13283-13322 Negative_regulation denotes inhibiting the antiapoptotic gene BCL-2
T7374 13576-13626 Regulation denotes regulating the expression of smooth muscle α-actin
T7373 12874-12887 Positive_regulation denotes Activated p53
T7372 13208-13278 Positive_regulation denotes transactivating proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS,
T7371 13095-13162 Positive_regulation denotes transactivating genes such as cyclin-dependent kinase inhibitor p21
T7370 13062-13065 Protein denotes p53
T7369 13111-13124 Protein denotes genes such as
T7368 13674-13677 Protein denotes Sun
T7367 13605-13626 Protein denotes smooth muscle α-actin
T7366 13111-13162 Protein denotes genes such as cyclin-dependent kinase inhibitor p21
T7365 12927-12937 Protein denotes senescence
T7364 13668-13672 Protein denotes VIα1
T7363 13183-13186 Protein denotes p53
T7362 13262-13268 Protein denotes SCOTIN
T7361 13649-13663 Protein denotes collagens IIα1
T7360 13294-13322 Protein denotes the antiapoptotic gene BCL-2
T7359 13176-13181 Protein denotes miR34
T7358 13294-13322 Protein denotes the antiapoptotic gene BCL-2
T7357 13274-13277 Protein denotes FAS
T7356 13016-13019 Protein denotes p53
T7355 13224-13250 Protein denotes proapoptotic genes such as
T7354 12874-12887 Protein denotes Activated p53
T7353 13256-13260 Protein denotes PUMA
T7352 13348-13351 Protein denotes p53
T7351 13398-13423 Entity denotes depending upon cell types
T7350 13224-13278 Protein denotes proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS,
T7349 13526-13529 Protein denotes p53
T5770 10648-10662 Positive_regulation denotes Activated WWOX
T5769 12713-12834 Gene_expression denotes the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity
T5768 10028-10107 Binding denotes Transiently overexpressed WWOX binds transcription factors AP-2, p73, and c-Jun
T5767 10028-10058 Gene_expression denotes Transiently overexpressed WWOX
T5766 10028-10058 Positive_regulation denotes Transiently overexpressed WWOX
T5765 10648-10729 Binding denotes Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1),
T5764 11802-11852 Binding denotes WWOX binds MEK in Jurkat T cells (Lin et al., 2011
T5763 12034-12060 Negative_regulation denotes Inhibition of MEK activity
T5762 10807-10844 Binding denotes WWOX binds Disheveled proteins (Dvl),
T5761 12146-12178 Gene_expression denotes expression of WWOX in A549 cells
T5760 12547-12580 Binding denotes binding with hyaluronidase Hyal-2
T5759 9815-9859 Binding denotes WW domain of WWOX may interact with proteins true
T5758 12331-12359 Phosphorylation denotes ectopic WWOX phosphorylation
T5757 12638-12685 Binding denotes Transforming growth factor β1 binds Hyal-2 as a
T5756 10954-10972 Positive_regulation denotes overexpressed WWOX
T5755 10954-10972 Gene_expression denotes overexpressed WWOX
T5754 10385-10473 Negative_regulation denotes No blocking of translocation of transcription factors to the nuclei by Wwox was observed
T5753 12204-12227 Positive_regulation denotes procaspase-9 activation
T5752 10684-10729 Phosphorylation denotes with serine 46-phosphorylated p53 (Figure 1),
T5751 10954-11040 Regulation denotes overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated
T5750 11096-11114 Positive_regulation denotes Overexpressed WWOX
T5749 11096-11114 Gene_expression denotes Overexpressed WWOX
T5748 10500-10583 Binding denotes WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of
T5747 11368-11420 Negative_regulation denotes down-regulating apoptosis inhibitor Bcl-2 and Bcl-xL
T5746 11368-11420 Negative_regulation denotes down-regulating apoptosis inhibitor Bcl-2 and Bcl-xL
T5745 12791-12834 Positive_regulation denotes enhancing the SMAD-driven promoter activity
T5744 9907-9935 Protein denotes ErbB4, Ezrin, SIMPLE, c-Jun,
T5743 10232-10236 Protein denotes Wwox
T5742 10500-10504 Protein denotes WWOX
T5741 7348-7355 Entity denotes steroid
T5740 11635-11639 Protein denotes WWOX
T5739 9846-9859 Protein denotes with proteins
T5738 6899-6903 Protein denotes Wwox
T5737 12204-12216 Protein denotes procaspase-9
T5736 11836-11839 Entity denotes Lin
T5735 11899-11919 Entity denotes the MEK/WWOX complex
T5734 10087-10091 Protein denotes AP-2
T5733 11855-11886 Entity denotes Phorbol myristate acetate (PMA)
T5732 10993-11006 Entity denotes the cytoplasm
T5731 7052-7066 Entity denotes two N-terminal
T5730 10453-10460 Protein denotes by Wwox
T5729 11160-11192 Entity denotes of human hepatic carcinoma cells
T5728 12157-12164 Protein denotes of WWOX
T5727 10170-10190 Entity denotes cancer cell survival
T5726 7137-7140 Protein denotes SDR
T5725 7154-7187 Entity denotes a proapoptotic C-terminal tail D3
T5724 10093-10096 Protein denotes p73
T5723 7331-7339 Protein denotes receptor
T5722 11820-11847 Entity denotes Jurkat T cells (Lin et al.,
T5721 11688-11701 Entity denotes others sites,
T5720 10558-10566 Protein denotes proteins
T5719 12638-12667 Protein denotes Transforming growth factor β1
T5718 11340-11364 Protein denotes of tumor necrosis factor
T5717 7452-7460 Entity denotes estrogen
T5716 12001-12004 Entity denotes MEK
T5715 11481-11485 Protein denotes WWOX
T5714 12775-12786 Entity denotes the nucleus
T5713 10818-10844 Protein denotes Disheveled proteins (Dvl),
T5712 10442-10452 Entity denotes the nuclei
T5711 10309-10319 Entity denotes the nuclei
T5710 10873-10915 Protein denotes Wnt/β-catenin signaling pathway (Figure 1)
T5709 7300-7304 Protein denotes WWOX
T5708 9895-9901 Protein denotes AP-2γ,
T5707 12022-12027 Entity denotes lipid
T5706 9873-9876 Protein denotes PPx
T5705 11907-11911 Protein denotes WWOX
T5704 9914-9934 Protein denotes Ezrin, SIMPLE, c-Jun
T5703 7439-7447 Entity denotes androgen
T5702 7112-7141 Protein denotes dehydrogenase/reductase (SDR)
T5701 10684-10729 Protein denotes with serine 46-phosphorylated p53 (Figure 1),
T5700 12240-12252 Entity denotes cytochrome C
T5699 12268-12284 Entity denotes the mitochondria
T5698 12560-12573 Protein denotes hyaluronidase
T5697 6799-6864 Protein denotes WW domain-containing oxidoreductase, known as WWOX, FOR, or WOX1,
T5696 12071-12082 Entity denotes TMZ-induced
T5695 12674-12680 Protein denotes Hyal-2
T5694 6934-6944 Entity denotes chromosome
T5693 7079-7148 Entity denotes a C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domain
T5692 10102-10107 Protein denotes c-Jun
T5691 11836-11845 Entity denotes Lin et al
T5690 10065-10107 Protein denotes transcription factors AP-2, p73, and c-Jun
T5689 9914-9928 Protein denotes Ezrin, SIMPLE,
T5688 9895-9942 Protein denotes AP-2γ, p73, ErbB4, Ezrin, SIMPLE, c-Jun, RUNX4,
T5687 11855-11886 Entity denotes Phorbol myristate acetate (PMA)
T5686 11384-11409 Protein denotes apoptosis inhibitor Bcl-2
T5685 9638-9662 Protein denotes Restoration of WWOX gene
T5684 12734-12751 Protein denotes WWOX/Hyal-2/Smad4
T5683 11932-11936 Protein denotes WWOX
T5682 6686-6707 Protein denotes tumor suppressors p53
T5681 7372-7386 Entity denotes its SDR domain
T5680 11096-11114 Protein denotes Overexpressed WWOX
T5679 7024-7036 Protein denotes WWOX protein
T5678 11303-11307 Protein denotes WWOX
T5677 10028-10058 Protein denotes Transiently overexpressed WWOX
T5644 12734-12751 Protein denotes WWOX/Hyal-2/Smad4
T5643 7052-7078 Entity denotes two N-terminal WW domains,
T5642 6712-6716 Protein denotes WWOX
T5641 11813-11816 Entity denotes MEK
T5640 11549-11558 Entity denotes chemicals
T5639 12686-12702 Protein denotes cognate receptor
T5638 10984-10989 Protein denotes Dvl-2
T5637 9815-9832 Entity denotes WW domain of WWOX
T5636 11611-11634 Entity denotes chemotherapeutic drugs,
T5635 6894-6903 Protein denotes WWOX/Wwox
T5634 6888-6908 Protein denotes mouse WWOX/Wwox gene
T5633 10877-10886 Protein denotes β-catenin
T5632 12382-12386 Entity denotes cell
T5631 12512-12542 Entity denotes the membrane/cytoskeleton area
T5630 6845-6855 Protein denotes WWOX, FOR,
T5629 10937-10940 Protein denotes Dvl
T5628 11899-11919 Entity denotes the MEK/WWOX complex
T5627 12604-12617 Protein denotes Phospho-Ezrin
T5626 7154-7187 Entity denotes a proapoptotic C-terminal tail D3
T5625 10839-10842 Protein denotes Dvl
T5624 7344-7365 Entity denotes sex steroid hormones,
T5623 10541-10547 Entity denotes Tyr33,
T5622 10648-10662 Protein denotes Activated WWOX
T5621 11439-11452 Protein denotes apoptotic p53
T5620 6859-6863 Protein denotes WOX1
T5619 7254-7259 Entity denotes et al
T5618 9650-9657 Protein denotes of WWOX
T5617 11728-11740 Entity denotes mitochondria
T5616 12187-12199 Protein denotes procaspase-3
T5615 11669-11674 Entity denotes Tyr33
T5614 10807-10811 Protein denotes WWOX
T5613 6910-6919 Protein denotes This gene
T5676 6757-6775 Entity denotes glioblastoma cells
T5675 6894-6903 Protein denotes WWOX/Wwox
T5674 11527-11530 Protein denotes p53
T5673 12048-12051 Entity denotes MEK
T5672 10689-10713 Entity denotes serine 46-phosphorylated
T5671 9876-9877 Entity denotes Y
T5670 11317-11364 Entity denotes the cytotoxic function of tumor necrosis factor
T5669 11955-11971 Entity denotes the mitochondria
T5668 12339-12343 Protein denotes WWOX
T5667 11744-11750 Entity denotes nuclei
T5666 10747-10750 Protein denotes p53
T5665 11414-11420 Protein denotes Bcl-xL
T5664 9907-9941 Protein denotes ErbB4, Ezrin, SIMPLE, c-Jun, RUNX4
T5663 10954-10972 Protein denotes overexpressed WWOX
T5662 10323-10330 Entity denotes neurons
T5661 11026-11040 Protein denotes Dvl-2-mediated
T5660 12489-12496 Protein denotes of WWOX
T5659 12817-12825 Entity denotes promoter
T5658 12555-12580 Protein denotes with hyaluronidase Hyal-2
T5657 9921-9927 Protein denotes SIMPLE
T5656 11882-11885 Entity denotes PMA
T5655 7081-7097 Entity denotes C-terminal short
T5654 9828-9832 Protein denotes WWOX
T5653 7024-7028 Protein denotes WWOX
T5652 12734-12738 Protein denotes WWOX
T5651 11855-11862 Entity denotes Phorbol
T5650 11215-11237 Entity denotes many cancer cell types
T5649 11802-11806 Protein denotes WWOX
T5648 12739-12745 Protein denotes Hyal-2
T5647 12604-12617 Protein denotes Phospho-Ezrin
T5646 7376-7379 Protein denotes SDR
T5645 11384-11403 Entity denotes apoptosis inhibitor
T2502 3958-3995 Negative_regulation denotes which blocks MGMT protein expression,
T2501 3911-3957 Positive_regulation denotes An increase in MGMT gene promoter methylation,
T2500 2946-2987 Regulation denotes MAPO2 gene encodes a novel 37-kDa protein
T2499 4393-4406 Positive_regulation denotes p53 signaling
T2498 2514-2562 Negative_regulation denotes inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
T2497 4792-4835 Binding denotes of mitochondrial respiratory chain coupling
T2496 3971-3995 Gene_expression denotes MGMT protein expression,
T2495 4836-4889 Negative_regulation denotes to suppress the production of reactive oxygen species
T2494 4044-4069 Positive_regulation denotes overexpressed microRNA-21
T2493 4044-4069 Gene_expression denotes overexpressed microRNA-21
T2492 4779-4889 Positive_regulation denotes Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species
T2491 6256-6284 Entity denotes other chemotherapeutic drugs
T2490 4795-4826 Entity denotes mitochondrial respiratory chain
T2489 6015-6018 Entity denotes TMZ
T2488 1425-1439 Entity denotes Friedman et al
T2487 3481-3485 Protein denotes Roos
T2486 4264-4273 Entity denotes Integrins
T2485 2946-2951 Protein denotes MAPO2
T2484 5262-5278 Entity denotes O6-methylguanine
T2483 5562-5574 Entity denotes resveratrol,
T2482 3971-3975 Protein denotes MGMT
T2481 2382-2409 Entity denotes The O6-methylguanine lesion
T2480 2717-2728 Entity denotes TMZ-induced
T2479 6382-6408 Entity denotes positive cancer stem cells
T2478 5519-5554 Entity denotes Interferon-β (IFN-β), levetiracetam
T2477 3851-3856 Entity denotes cells
T2476 2221-2233 Entity denotes Temozolomide
T2475 3115-3163 Protein denotes by O6-methylguanine-DNA methyltransferase (MGMT)
T2474 2965-2987 Protein denotes a novel 37-kDa protein
T2473 5047-5051 Protein denotes MGMT
T2472 5091-5102 Entity denotes lomeguatrib
T2471 5262-5286 Entity denotes O6-methylguanine adducts
T2470 5594-5597 Protein denotes VAP
T2469 5627-5630 Entity denotes TMZ
T2468 3085-3163 Entity denotes a substrate for direct repair by O6-methylguanine-DNA methyltransferase (MGMT)
T2467 4953-4956 Entity denotes TMZ
T2466 1255-1261 Entity denotes Silber
T2465 1733-1787 Entity denotes the monofunctional alkylating agent temozolomide (TMZ)
T2464 2548-2562 Protein denotes by a pan-Bcl-2
T2463 1581-1591 Entity denotes Haar et al
T2462 4695-4712 Entity denotes N7-methylguanine,
T2461 3054-3081 Entity denotes The O6-methylguanine lesion
T2460 4906-4944 Protein denotes by cytochrome c oxidase contributes in
T2459 6248-6251 Entity denotes TMZ
T2458 3829-3833 Protein denotes MGMT
T2457 6521-6529 Protein denotes of CD133
T2456 1870-1873 Entity denotes TMZ
T2455 5865-5868 Entity denotes TMZ
T2454 5837-5842 Protein denotes STAT3
T2453 3346-3354 Protein denotes proteins
T2452 3739-3742 Protein denotes MMR
T2451 2647-2653 Entity denotes of TMZ
T2450 3054-3081 Entity denotes The O6-methylguanine lesion
T2449 4177-4188 Protein denotes MicroRNA-21
T2448 4078-4087 Protein denotes Bax/Bcl-2
T2447 5047-5068 Entity denotes MGMT pseudosubstrates
T2446 3489-3491 Entity denotes al
T2445 2879-2910 Entity denotes O6-methylguanine lesion-induced
T2444 2319-2335 Entity denotes N7-methylguanine
T2443 3923-3957 Protein denotes in MGMT gene promoter methylation,
T2442 3273-3289 Entity denotes O6-methylguanine
T2441 5824-5833 Entity denotes inhibitor
T2440 5402-5405 Entity denotes NAD
T2439 3273-3289 Entity denotes O6-methylguanine
T2438 1904-1933 Entity denotes cancer stem cells, microRNAs,
T2437 3926-3930 Protein denotes MGMT
T2436 5013-5016 Entity denotes TMZ
T2435 4078-4087 Protein denotes Bax/Bcl-2
T2434 6172-6175 Entity denotes TMZ
T2433 3158-3162 Protein denotes MGMT
T2432 4652-4690 Entity denotes the cytotoxic lesions N3-methyladenine
T2431 3569-3572 Entity denotes TMZ
T2430 5579-5598 Entity denotes valproic acid (VAP)
T2429 1966-2073 Entity denotes tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many
T2428 2563-2576 Entity denotes inhibitor (−)
T2427 5704-5738 Entity denotes Resveratrol, a natural polyphenol,
T2426 3371-3431 Protein denotes protein kinase that ultimately leads to apoptotic cell death
T2425 5227-5230 Entity denotes TMZ
T2424 6100-6103 Protein denotes Sun
T2423 3520-3524 Protein denotes MGMT
T2422 5818-5852 Protein denotes STAT3 inhibitor or STAT3 knockdown
T2421 3766-3769 Entity denotes TMZ
T2420 2563-2585 Entity denotes inhibitor (−)-gossypol
T2419 2844-2852 Protein denotes C1orf201
T2418 5262-5278 Entity denotes O6-methylguanine
T2417 2837-2853 Protein denotes MAPO2 (C1orf201)
T2416 3608-3621 Entity denotes Pollack et al
T2415 5265-5278 Entity denotes methylguanine
T2414 4738-4741 Entity denotes TMZ
T2413 6076-6079 Entity denotes TMZ
T2412 1947-1950 Entity denotes DNA
T2411 2837-2858 Protein denotes MAPO2 (C1orf201) gene
T2410 4232-4244 Entity denotes cancer cells
T2409 3936-3944 Entity denotes promoter
T2408 6376-6381 Protein denotes CD133
T2407 4044-4069 Protein denotes overexpressed microRNA-21
T2406 3826-3847 Entity denotes of MGMT gene promoter
T2405 2051-2063 Protein denotes STAT3 kinase
T2404 5748-5751 Entity denotes TMZ
T2403 4158-4161 Protein denotes Shi
T2402 5434-5437 Entity denotes TMZ
T2401 2796-2829 Entity denotes GBM cells (Knizhnik et al., 2013)
T2400 1752-1768 Entity denotes alkylating agent
T2399 2051-2056 Protein denotes STAT3
T2398 5770-5785 Protein denotes NF-κB-dependent
T2397 4135-4146 Entity denotes TMZ-induced
T2396 5717-5737 Entity denotes a natural polyphenol
T2395 3826-3847 Protein denotes of MGMT gene promoter
T2394 5123-5129 Entity denotes to TMZ
T2393 6453-6470 Entity denotes cancer stem cells
T2392 2279-2295 Entity denotes O6-methylguanine
T2391 1783-1786 Entity denotes TMZ
T2390 4430-4441 Entity denotes glioma cell
T2389 2382-2409 Entity denotes The O6-methylguanine lesion
T2388 3971-3983 Protein denotes MGMT protein
T2387 6546-6570 Entity denotes glioma cancer stem cells
T2386 4393-4396 Protein denotes p53
T2385 3260-3264 Protein denotes MGMT
T2384 2319-2335 Entity denotes N7-methylguanine
T2383 6119-6136 Entity denotes Cancer stem cells
T2382 6209-6218 Entity denotes stem cell
T2381 3018-3027 Protein denotes this gene
T2380 6583-6606 Entity denotes its biological function
T2379 5153-5197 Entity denotes Methoxyamine-blocker of base excision repair
T2378 2279-2295 Entity denotes O6-methylguanine
T2377 2253-2268 Entity denotes of DNA lesions,
T2376 5070-5086 Entity denotes O6-benzylguanine
T2375 4082-4087 Protein denotes Bcl-2
T2374 5639-5653 Protein denotes MGMT-dependent
T2373 1934-1938 Entity denotes drug
T2372 4456-4485 Entity denotes TMZ (Janouskova et al., 2012)
T2371 4656-4665 Entity denotes cytotoxic
T2370 4098-4107 Protein denotes caspase-3
T2369 6431-6448 Entity denotes normal stem cells
T2368 4568-4599 Protein denotes The base excision repair enzyme
T2367 5519-5540 Protein denotes Interferon-β (IFN-β),
T2366 2525-2547 Protein denotes of antiapoptotic Bcl-2
T2365 4922-4929 Protein denotes oxidase
T2364 2879-2910 Entity denotes O6-methylguanine lesion-induced
T2363 4695-4712 Entity denotes N7-methylguanine,
T2362 4891-4894 Protein denotes ROS
T2361 5533-5538 Protein denotes IFN-β
T2360 2297-2313 Entity denotes N3-methyladenine
T2359 2946-2956 Protein denotes MAPO2 gene
T551 665-725 Binding denotes WWOX is known to physically bind and stabilize wild type p53
T550 379-402 Gene_expression denotes of WWOX gene expression
T549 545-581 Gene_expression denotes ectopic expression of wild type WWOX
T548 945-960 Positive_regulation denotes WWOX activation
T547 665-725 Regulation denotes WWOX is known to physically bind and stabilize wild type p53
T545 945-949 Protein denotes WWOX
T544 1036-1039 Entity denotes TMZ
T543 564-581 Protein denotes of wild type WWOX
T542 964-981 Entity denotes therapeutic drugs
T541 310-332 Protein denotes a proapoptotic protein
T540 618-663 Entity denotes human glioblastoma cells harboring mutant p53
T539 382-386 Protein denotes WWOX
T538 785-788 Protein denotes p53
T537 252-287 Protein denotes WW domain-containing oxidoreductase
T536 988-991 Protein denotes p53
T535 210-228 Entity denotes temozolomide (TMZ)
T534 301-305 Protein denotes WOX1
T533 455-463 Entity denotes promoter
T532 252-292 Protein denotes WW domain-containing oxidoreductase WWOX
T531 354-372 Protein denotes a tumor suppressor
T530 909-916 Protein denotes of WWOX
T528 852-876 Protein denotes mutant p53, or isoforms,
T527 653-663 Protein denotes mutant p53
T526 233-250 Entity denotes therapeutic drugs
T525 89-109 Protein denotes Tumor suppressor p53
T524 665-669 Protein denotes WWOX
T523 224-227 Entity denotes TMZ
T522 793-797 Protein denotes WWOX
T521 425-447 Entity denotes malignant cancer cells
T520 712-725 Protein denotes wild type p53
R259 T520 T547 themeOf wild type p53,WWOX is known to physically bind and stabilize wild type p53
R260 T524 T547 causeOf WWOX,WWOX is known to physically bind and stabilize wild type p53
R261 T524 T551 themeOf WWOX,WWOX is known to physically bind and stabilize wild type p53
R262 T539 T550 themeOf WWOX,of WWOX gene expression
R263 T543 T549 themeOf of wild type WWOX,ectopic expression of wild type WWOX
R264 T545 T548 themeOf WWOX,WWOX activation
R1554 T2359 T2500 causeOf MAPO2 gene,MAPO2 gene encodes a novel 37-kDa protein
R1556 T2366 T2498 themeOf of antiapoptotic Bcl-2,inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
R1562 T2386 T2499 causeOf p53,p53 signaling
R1563 T2388 T2496 themeOf MGMT protein,"MGMT protein expression,"
R1568 T2406 T2458 partOf of MGMT gene promoter,MGMT
R1569 T2407 T2493 themeOf overexpressed microRNA-21,overexpressed microRNA-21
R1570 T2407 T2494 themeOf overexpressed microRNA-21,overexpressed microRNA-21
R1571 T2464 T2498 causeOf by a pan-Bcl-2,inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2
R1572 T2474 T2500 themeOf a novel 37-kDa protein,MAPO2 gene encodes a novel 37-kDa protein
R1573 T2490 T2497 themeOf mitochondrial respiratory chain,of mitochondrial respiratory chain coupling
R1574 T2496 T2502 themeOf "MGMT protein expression,","which blocks MGMT protein expression,"
R1575 T2497 T2492 themeOf of mitochondrial respiratory chain coupling,Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species
R3832 T5614 T5762 themeOf WWOX,"WWOX binds Disheveled proteins (Dvl),"
R3834 T5622 T5770 themeOf Activated WWOX,Activated WWOX
R3842 T5637 T5759 themeOf WW domain of WWOX,WW domain of WWOX may interact with proteins
R3844 T5641 T5764 themeOf MEK,"WWOX binds MEK in Jurkat T cells (Lin et al., 2011"
R3847 T5649 T5764 themeOf WWOX,"WWOX binds MEK in Jurkat T cells (Lin et al., 2011"
R3852 T5658 T5760 themeOf with hyaluronidase Hyal-2,binding with hyaluronidase Hyal-2
R3855 T5661 T5751 causeOf Dvl-2-mediated,overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated
R3858 T5663 T5751 themeOf overexpressed WWOX,overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated
R3859 T5663 T5755 themeOf overexpressed WWOX,overexpressed WWOX
R3860 T5663 T5756 themeOf overexpressed WWOX,overexpressed WWOX
R3861 T5665 T5747 themeOf Bcl-xL,down-regulating apoptosis inhibitor Bcl-2 and Bcl-xL
R3862 T5668 T5758 themeOf WWOX,ectopic WWOX phosphorylation
R3863 T5672 T5701 partOf serine 46-phosphorylated,"with serine 46-phosphorylated p53 (Figure 1),"
R3864 T5672 T5752 siteOf serine 46-phosphorylated,"with serine 46-phosphorylated p53 (Figure 1),"
R3867 T5677 T5766 themeOf Transiently overexpressed WWOX,Transiently overexpressed WWOX
R3868 T5677 T5767 themeOf Transiently overexpressed WWOX,Transiently overexpressed WWOX
R3869 T5677 T5768 themeOf Transiently overexpressed WWOX,"Transiently overexpressed WWOX binds transcription factors AP-2, p73, and c-Jun"
R3870 T5680 T5749 themeOf Overexpressed WWOX,Overexpressed WWOX
R3871 T5680 T5750 themeOf Overexpressed WWOX,Overexpressed WWOX
R3873 T5684 T5769 themeOf WWOX/Hyal-2/Smad4,the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity
R3875 T5686 T5746 themeOf apoptosis inhibitor Bcl-2,down-regulating apoptosis inhibitor Bcl-2 and Bcl-xL
R3877 T5690 T5768 themeOf "transcription factors AP-2, p73, and c-Jun","Transiently overexpressed WWOX binds transcription factors AP-2, p73, and c-Jun"
R3881 T5695 T5757 themeOf Hyal-2,Transforming growth factor β1 binds Hyal-2 as a
R3883 T5701 T5752 themeOf "with serine 46-phosphorylated p53 (Figure 1),","with serine 46-phosphorylated p53 (Figure 1),"
R3884 T5701 T5765 themeOf "with serine 46-phosphorylated p53 (Figure 1),","Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1),"
R3885 T5737 T5753 themeOf procaspase-9,procaspase-9 activation
R3886 T5739 T5759 themeOf with proteins,WW domain of WWOX may interact with proteins
R3887 T5713 T5762 themeOf "Disheveled proteins (Dvl),","WWOX binds Disheveled proteins (Dvl),"
R3888 T5742 T5748 themeOf WWOX,"WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of"
R3889 T5719 T5757 themeOf Transforming growth factor β1,Transforming growth factor β1 binds Hyal-2 as a
R3891 T5720 T5748 themeOf proteins,"WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of"
R3892 T5728 T5761 themeOf of WWOX,expression of WWOX in A549 cells
R3893 T5730 T5754 causeOf by Wwox,No blocking of translocation of transcription factors to the nuclei by Wwox was observed
R5189 T7350 T7372 themeOf "proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS,","transactivating proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS,"
R5190 T7354 T7373 themeOf Activated p53,Activated p53
R5191 T7360 T7375 themeOf the antiapoptotic gene BCL-2,inhibiting the antiapoptotic gene BCL-2
R5192 T7366 T7371 themeOf genes such as cyclin-dependent kinase inhibitor p21,transactivating genes such as cyclin-dependent kinase inhibitor p21
R5740 T8215 T8257 locationOf cytoplasm,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5741 T8215 T8258 locationOf cytoplasm,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5742 T8216 T8254 themeOf mRNA,"alternative mRNA splicing, multiple gene promoters,"
R5743 T8217 T8252 themeOf Δ133p53γ,Co-expression of Δ133p53β or Δ133p53γ with p53
R5744 T8222 T8255 themeOf "Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005)","Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005)"
R5745 T8224 T8250 themeOf p53,Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional
R5746 T8224 T8251 themeOf p53,Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional
R5747 T8226 T8253 themeOf Δ133p53β,Co-expression of Δ133p53β or Δ133p53γ with p53
R5748 T8228 T8249 causeOf Δ133p53,Δ133p53 differentially regulates gene expression in p53-dependent and -independent
R5749 T8232 T8219 partOf Bax promoters,Bax
R5750 T8233 T8258 themeOf p53γ,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5751 T8234 T8257 locationOf the nucleus,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5752 T8234 T8258 locationOf the nucleus,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5753 T8238 T8257 themeOf Δ133p53β,p53γ and Δ133p53β are localized in the nucleus and cytoplasm
R5754 T8240 T8255 locationOf "in the cytoplasm (Bourdon et al., 2005)","Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005)"
R5755 T8245 T8256 causeOf p53-dependent,gene expression in p53-dependent
R5756 T8247 T8259 themeOf of p53,co-expression of p53 with Δ133p53
R5757 T8252 T8250 causeOf Co-expression of Δ133p53β or Δ133p53γ with p53,Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional
R5758 T8253 T8251 causeOf Co-expression of Δ133p53β or Δ133p53γ with p53,Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional
R5759 T8259 T8248 themeOf co-expression of p53 with Δ133p53,co-expression of p53 with Δ133p53 suppresses
R6228 T9124 T9175 themeOf of WWOX,downregulation of WWOX
R6229 T9126 T9178 themeOf Mutant p53 proteins,Mutant p53 proteins cannot bind ectopic WWOX in GBM cells
R6230 T9135 T9176 themeOf of this protein with WWOX,binding of this protein with WWOX
R6231 T9153 T9177 themeOf WWOX,Altered WWOX expression
R6232 T9166 T9179 themeOf Activated WWOX,Activated WWOX
R6233 T9167 T9178 themeOf ectopic WWOX,Mutant p53 proteins cannot bind ectopic WWOX in GBM cells
R6234 T9168 T9172 themeOf wild type p53,Activated WWOX binds wild type p53 with Ser46 phosphorylation
R6235 T9169 T9173 themeOf overexpressed WWOX,overexpressed WWOX
R6236 T9169 T9174 themeOf overexpressed WWOX,overexpressed WWOX
R6237 T9177 T9171 themeOf Altered WWOX expression,Altered WWOX expression
R7783 T11487 T11594 themeOf of ROS,generation of ROS to curb the cancer cell growth and invasion
R7784 T11510 T11598 themeOf with WWOX,"In most cases, we have shown that p53 functionally interacts with WWOX"
R7785 T11527 T11595 themeOf WWOX,"WWOX binds MEK,"
R7786 T11536 T11597 themeOf of ROS,generation of ROS
R7787 T11540 T11593 themeOf WWOX,low WWOX expression areas
R7788 T11550 T11595 themeOf "MEK,","WWOX binds MEK,"
R7789 T11553 T11598 themeOf p53,"In most cases, we have shown that p53 functionally interacts with WWOX"
R7790 T11559 T11592 themeOf WWOX,of WWOX expression
R7791 T11580 T11591 themeOf of TIAF1,Ectopic expression of TIAF1
R7792 T11581 T11596 themeOf ectopic WWOX,"In this event, ectopic WWOX is activated for inducing apoptosis"
R9475 T13699 T13773 themeOf WWOX,WWOX binds Tau via its SDR domain
R9476 T13700 T13769 themeOf the released WWOX,the released WWOX
R9477 T13703 T13772 themeOf Hyal-2,association with Hyal-2 and phospho-Ezrin
R9478 T13705 T13771 themeOf Dvl,binding Dvl
R9479 T13706 T13768 themeOf WWOX,WWOX is phosphorylated in Tyr33 and binds p53
R9480 T13706 T13770 themeOf WWOX,WWOX is phosphorylated in Tyr33
R9481 T13714 T13774 themeOf WWOX,WWOX binds Hyal-2
R9482 T13722 T13775 themeOf conserved tyrosine phosphorylation sites,conserved tyrosine phosphorylation sites
R9483 T13731 T13706 partOf Tyr33,WWOX
R9484 T13731 T13770 siteOf Tyr33,WWOX is phosphorylated in Tyr33
R9485 T13737 T13774 themeOf Hyal-2,WWOX binds Hyal-2
R9486 T13739 T13768 themeOf p53,WWOX is phosphorylated in Tyr33 and binds p53
R9487 T13747 T13749 partOf its SDR domain,Tau
R9488 T13747 T13773 siteOf its SDR domain,WWOX binds Tau via its SDR domain
R9489 T13749 T13773 themeOf Tau,WWOX binds Tau via its SDR domain
R9490 T13753 T13772 themeOf phospho-Ezrin,association with Hyal-2 and phospho-Ezrin
R9491 T13755 T13767 causeOf Phorbol ester,Phorbol ester stimulates the dissociation of MEK/WWOX complex in Jurkat T cell
R10155 T14754 T14785 themeOf ectopic WWOX,ectopic WWOX binds
R10156 T14766 T14786 themeOf endogenous wild type p53,GBM cells expressing endogenous wild type p53
R10157 T14777 T14784 themeOf WWOX,WWOX binds

DLUT931

Id Subject Object Predicate Lexical cue
T397 17-21 Protein denotes WWOX
T398 26-29 Protein denotes p53
T415 30-41 Regulation denotes Alterations
T5191 10102-10107 Protein denotes c-Jun
T14451 14604-14611 Positive_regulation denotes ectopic
T14450 14653-14663 Gene_expression denotes expressing
T14449 14617-14626 Positive_regulation denotes induction
T14448 14559-14564 Binding denotes binds
T14447 14519-14529 Gene_expression denotes expressing
T14446 14392-14404 Binding denotes interactions
T14445 14284-14295 Negative_regulation denotes antagonizes
T14444 14261-14266 Binding denotes binds
T14443 14195-14205 Gene_expression denotes expressing
T14442 14011-14019 Negative_regulation denotes deletion
T14441 13932-13944 Localization denotes localization
T14440 13866-13877 Binding denotes DNA-binding
T14439 14664-14667 Protein denotes p53
T14438 14612-14616 Protein denotes WWOX
T14437 14565-14568 Protein denotes p53
T14436 14554-14558 Protein denotes WWOX
T14435 14515-14518 Protein denotes p53
T14434 14483-14487 Protein denotes WWOX
T14433 14437-14441 Protein denotes WWOX
T14432 14420-14423 Protein denotes p53
T14431 14256-14260 Protein denotes WWOX
T14430 14296-14299 Protein denotes p53
T14429 14227-14230 Protein denotes p53
T14428 14151-14155 Protein denotes WWOX
T14427 14104-14107 Protein denotes p53
T14426 14095-14099 Protein denotes WWOX
T14425 14031-14034 Protein denotes p53
T14424 13772-13775 Protein denotes p53
T14423 13728-13732 Protein denotes WWOX
T14422 13720-13723 Protein denotes p53
T13425 8857-8864 Phosphorylation denotes phospho
T13424 8829-8840 Binding denotes association
T13423 8795-8804 Binding denotes recruited
T13422 8730-8742 Localization denotes translocates
T13421 8716-8724 Localization denotes released
T13420 8597-8607 Negative_regulation denotes inhibiting
T13419 8620-8626 Localization denotes import
T13418 8581-8588 Binding denotes binding
T13417 8494-8499 Binding denotes binds
T13416 8407-8414 Binding denotes binding
T13415 8182-8187 Binding denotes binds
T13414 8154-8168 Phosphorylation denotes phosphorylated
T13413 9118-9144 Protein denotes hyaluronoglucosaminidase 2
T13412 9110-9116 Protein denotes Hyal-2
T13411 9073-9108 Protein denotes activated Cdc42-associated kinase 1
T13410 9067-9071 Protein denotes Ack1
T13409 8952-8958 Protein denotes Hyal-2
T13408 8941-8945 Protein denotes WWOX
T13407 8933-8939 Protein denotes TGF-β1
T13406 8910-8916 Protein denotes TGF-β1
T13405 8872-8878 Protein denotes Hyal-2
T13404 8865-8870 Protein denotes Ezrin
T13403 8846-8852 Protein denotes Hyal-2
T13402 8787-8791 Protein denotes WWOX
T13401 8725-8729 Protein denotes WWOX
T13400 8524-8528 Protein denotes WWOX
T13399 8489-8493 Protein denotes WWOX
T13398 8500-8503 Protein denotes Tau
T13397 8367-8372 Protein denotes ERBB4
T13396 8356-8361 Protein denotes c-Jun
T13395 8349-8354 Protein denotes RUNX2
T13394 8280-8284 Protein denotes WWOX
T13393 8188-8191 Protein denotes p53
T13392 8146-8150 Protein denotes WWOX
T13391 7575-7579 Protein denotes WWOX
T13390 7533-7537 Protein denotes WWOX
T12526 22781-22785 Protein denotes WWOX
T12525 22773-22776 Protein denotes p53
T11157 22579-22586 Regulation denotes effects
T11156 22595-22605 Negative_regulation denotes deficiency
T11155 22009-22016 Positive_regulation denotes induces
T11154 21998-22008 Gene_expression denotes expression
T11153 21627-21635 Negative_regulation denotes knockout
T11152 21468-21476 Gene_expression denotes negative
T11151 21407-21417 Gene_expression denotes expression
T11150 21372-21382 Gene_expression denotes expressing
T11149 21305-21313 Gene_expression denotes negative
T11148 21271-21279 Gene_expression denotes positive
T11147 21229-21237 Gene_expression denotes negative
T11146 21173-21181 Gene_expression denotes positive
T11145 21124-21132 Gene_expression denotes negative
T11144 20519-20529 Gene_expression denotes expression
T11143 20388-20392 Negative_regulation denotes loss
T11142 20312-20316 Negative_regulation denotes lack
T11141 20325-20335 Gene_expression denotes expression
T11140 20073-20084 Binding denotes interacting
T11139 19361-19372 Regulation denotes upregulated
T11138 19076-19085 Negative_regulation denotes interfere
T11137 19027-19034 Binding denotes binding
T11136 18845-18854 Binding denotes interacts
T11135 18700-18708 Positive_regulation denotes inducing
T11134 18639-18648 Positive_regulation denotes activated
T11133 17848-17853 Binding denotes binds
T11113 20586-20590 Protein denotes WWOX
T11112 20577-20580 Protein denotes p53
T11111 20533-20538 Protein denotes TIAF1
T11110 20396-20400 Protein denotes WWOX
T11109 20320-20324 Protein denotes WWOX
T11108 20050-20054 Protein denotes CD44
T11107 19903-19907 Protein denotes mTOR
T11106 19898-19901 Protein denotes Akt
T11105 19706-19709 Protein denotes p53
T11104 19657-19661 Protein denotes WWOX
T11103 19321-19325 Protein denotes PTEN
T11102 19314-19319 Protein denotes Smad4
T11101 19308-19312 Protein denotes WWOX
T11100 19303-19306 Protein denotes p53
T11099 19126-19129 Protein denotes p53
T11098 19117-19121 Protein denotes WWOX
T11097 19023-19026 Protein denotes p53
T11096 18860-18864 Protein denotes WWOX
T11095 18828-18831 Protein denotes p53
T11094 18756-18759 Protein denotes p53
T11093 18692-18696 Protein denotes WWOX
T11092 18631-18635 Protein denotes WWOX
T11091 17843-17847 Protein denotes WWOX
T11090 17774-17777 Protein denotes p53
T11089 17762-17766 Protein denotes WWOX
T11088 17685-17689 Protein denotes WWOX
T11132 17741-17748 Binding denotes Binding
T11131 22590-22594 Protein denotes WWOX
T11130 22499-22503 Protein denotes WWOX
T11129 22424-22428 Protein denotes WWOX
T11128 22416-22419 Protein denotes p53
T11127 22181-22185 Protein denotes WWOX
T11126 21988-21992 Protein denotes Wwox
T11125 21823-21827 Protein denotes Wwox
T11124 21622-21626 Protein denotes Wwox
T11123 21463-21467 Protein denotes WWOX
T11122 21402-21406 Protein denotes WWOX
T11121 21367-21371 Protein denotes WWOX
T11120 21300-21304 Protein denotes WWOX
T11119 21266-21270 Protein denotes WWOX
T11118 21224-21228 Protein denotes WWOX
T11117 21168-21172 Protein denotes WWOX
T11116 21119-21123 Protein denotes WWOX
T11115 21067-21071 Protein denotes WWOX
T11114 20876-20880 Protein denotes Wwox
T8984 17597-17607 Gene_expression denotes expressing
T8983 17490-17494 Binding denotes bind
T8982 17211-17218 Binding denotes binding
T8981 17081-17096 Phosphorylation denotes phosphorylation
T8980 17050-17055 Binding denotes binds
T8979 17035-17044 Positive_regulation denotes Activated
T8978 16993-17009 Negative_regulation denotes gain-of-function
T8977 16968-16980 Binding denotes interactions
T8976 16652-16658 Regulation denotes effect
T8975 16671-16681 Gene_expression denotes expressing
T8974 16632-16639 Negative_regulation denotes ectopic
T8973 16468-16481 Positive_regulation denotes overexpressed
T8972 16274-16281 Regulation denotes Altered
T8971 16325-16339 Negative_regulation denotes downregulation
T8970 16287-16297 Gene_expression denotes expression
T8969 16217-16223 Negative_regulation denotes reduce
T8968 16064-16068 Negative_regulation denotes Loss
T8967 17608-17611 Protein denotes p53
T8966 17568-17572 Protein denotes WWOX
T8965 17526-17530 Protein denotes WWOX
T8964 17503-17507 Protein denotes WWOX
T8963 17470-17473 Protein denotes p53
T8962 17334-17338 Protein denotes WWOX
T8961 17318-17321 Protein denotes p53
T8960 17240-17244 Protein denotes WWOX
T8959 17203-17209 Protein denotes Δ40p53
T8958 17066-17069 Protein denotes p53
T8957 17045-17049 Protein denotes WWOX
T8956 17029-17033 Protein denotes WWOX
T8955 17013-17016 Protein denotes p53
T8954 16784-16793 Protein denotes caspase-3
T8953 16709-16713 Protein denotes WWOX
T8952 16640-16644 Protein denotes WWOX
T8951 16692-16695 Protein denotes p53
T8950 16552-16555 Protein denotes p53
T8949 16482-16486 Protein denotes WWOX
T8948 16343-16347 Protein denotes WWOX
T8947 16282-16286 Protein denotes WWOX
T8946 16205-16208 Protein denotes p53
T8945 16149-16152 Protein denotes p53
T8944 16083-16086 Protein denotes p53
T8943 15852-15855 Protein denotes p53
T7885 15734-15740 Regulation denotes affect
T7884 15678-15691 Gene_expression denotes Co-expression
T7883 15471-15484 Gene_expression denotes co-expression
T7882 15429-15438 Positive_regulation denotes increases
T7881 15397-15412 Gene_expression denotes Co-transfection
T7880 15346-15355 Localization denotes localized
T7879 15294-15303 Localization denotes localized
T7878 15200-15209 Localization denotes localized
T7877 15077-15087 Gene_expression denotes expression
T7876 15781-15784 Protein denotes Bax
T7875 15773-15776 Protein denotes p21
T7874 15741-15744 Protein denotes p53
T7873 15721-15724 Protein denotes p53
T7872 15707-15715 Protein denotes Δ133p53γ
T7871 15695-15703 Protein denotes Δ133p53β
T7870 15615-15618 Protein denotes p53
T7869 15563-15570 Protein denotes Δ133p53
T7868 15416-15419 Protein denotes p53
T7867 15516-15519 Protein denotes p53
T7866 15497-15504 Protein denotes Δ133p53
T7865 15488-15491 Protein denotes p53
T7864 15439-15442 Protein denotes p53
T7863 15424-15428 Protein denotes p53β
T7862 15334-15342 Protein denotes Δ133p53γ
T7861 15281-15289 Protein denotes Δ133p53β
T7860 15272-15276 Protein denotes p53γ
T7859 15191-15195 Protein denotes p53β
T7858 15178-15185 Protein denotes Δ133p53
T7857 15173-15176 Protein denotes p53
T7856 15091-15094 Protein denotes p53
T7855 14874-14877 Protein denotes p53
T7089 13576-13586 Regulation denotes regulating
T7088 13591-13601 Gene_expression denotes expression
T7087 13283-13293 Negative_regulation denotes inhibiting
T7086 12874-12883 Positive_regulation denotes Activated
T7085 13668-13672 Protein denotes VIα1
T7084 13649-13663 Protein denotes collagens IIα1
T7083 13605-13626 Protein denotes smooth muscle α-actin
T7082 13526-13529 Protein denotes p53
T7081 13348-13351 Protein denotes p53
T7080 13262-13268 Protein denotes SCOTIN
T7079 13256-13260 Protein denotes PUMA
T7078 13251-13254 Protein denotes BAX
T7077 13183-13186 Protein denotes p53
T7076 13176-13181 Protein denotes miR34
T7075 13159-13162 Protein denotes p21
T7074 13062-13065 Protein denotes p53
T7073 13317-13322 Protein denotes BCL-2
T7072 13274-13277 Protein denotes FAS
T7071 13016-13019 Protein denotes p53
T7070 12884-12887 Protein denotes p53
T5252 12668-12673 Binding denotes binds
T5251 12604-12611 Phosphorylation denotes Phospho
T5250 12547-12554 Binding denotes binding
T5249 12331-12338 Positive_regulation denotes ectopic
T5248 12344-12359 Phosphorylation denotes phosphorylation
T5247 12217-12227 Positive_regulation denotes activation
T5246 12146-12156 Gene_expression denotes expression
T5245 11940-11951 Localization denotes translocate
T5244 11924-11931 Positive_regulation denotes induces
T5243 11807-11812 Binding denotes binds
T5242 11650-11665 Phosphorylation denotes phosphorylation
T5241 11425-11438 Positive_regulation denotes up-regulating
T5240 11368-11383 Negative_regulation denotes down-regulating
T5239 11096-11109 Positive_regulation denotes Overexpressed
T5190 10093-10096 Protein denotes p73
T5189 10087-10091 Protein denotes AP-2
T5188 10054-10058 Protein denotes WWOX
T5187 9936-9941 Protein denotes RUNX4
T5186 9929-9934 Protein denotes c-Jun
T5185 9921-9927 Protein denotes SIMPLE
T5184 9914-9919 Protein denotes Ezrin
T5183 9907-9912 Protein denotes ErbB4
T5182 9902-9905 Protein denotes p73
T5181 9895-9900 Protein denotes AP-2γ
T5180 9828-9832 Protein denotes WWOX
T5179 9653-9657 Protein denotes WWOX
T5178 9234-9238 Protein denotes WWOX
T5177 7300-7304 Protein denotes WWOX
T5176 7024-7028 Protein denotes WWOX
T5175 6899-6903 Protein denotes Wwox
T5174 6894-6898 Protein denotes WWOX
T5173 6859-6863 Protein denotes WOX1
T5172 6851-6854 Protein denotes FOR
T5171 6845-6849 Protein denotes WWOX
T5170 6799-6834 Protein denotes WW domain-containing oxidoreductase
T5169 6712-6716 Protein denotes WWOX
T5168 6704-6707 Protein denotes p53
T5238 10973-10983 Binding denotes sequesters
T5237 10954-10967 Positive_regulation denotes overexpressed
T5236 10812-10817 Binding denotes binds
T5235 10736-10746 Negative_regulation denotes stabilizes
T5234 10696-10713 Phosphorylation denotes 46-phosphorylated
T5233 10674-10683 Binding denotes interacts
T5232 10648-10657 Positive_regulation denotes Activated
T5231 10552-10557 Binding denotes binds
T5230 10508-10517 Positive_regulation denotes activated
T5229 10388-10396 Negative_regulation denotes blocking
T5228 10132-10142 Localization denotes relocation
T5227 10059-10064 Binding denotes binds
T5226 10040-10053 Positive_regulation denotes overexpressed
T5225 9638-9649 Negative_regulation denotes Restoration
T5224 9249-9256 Regulation denotes altered
T5223 9220-9230 Gene_expression denotes Expression
T5222 12674-12680 Protein denotes Hyal-2
T5221 12638-12667 Protein denotes Transforming growth factor β1
T5220 12612-12617 Protein denotes Ezrin
T5219 12574-12580 Protein denotes Hyal-2
T5218 12492-12496 Protein denotes WWOX
T5217 12339-12343 Protein denotes WWOX
T5216 12204-12216 Protein denotes procaspase-9
T5215 12187-12199 Protein denotes procaspase-3
T5214 12160-12164 Protein denotes WWOX
T5213 11932-11936 Protein denotes WWOX
T5212 11802-11806 Protein denotes WWOX
T5211 11635-11639 Protein denotes WWOX
T5210 11527-11530 Protein denotes p53
T5209 11481-11485 Protein denotes WWOX
T5208 11449-11452 Protein denotes p53
T5207 11414-11420 Protein denotes Bcl-xL
T5206 11404-11409 Protein denotes Bcl-2
T5205 11343-11364 Protein denotes tumor necrosis factor
T5204 11303-11307 Protein denotes WWOX
T5203 11110-11114 Protein denotes WWOX
T5202 11026-11031 Protein denotes Dvl-2
T5201 10984-10989 Protein denotes Dvl-2
T5200 10968-10972 Protein denotes WWOX
T5199 10877-10886 Protein denotes β-catenin
T5198 10807-10811 Protein denotes WWOX
T5197 10747-10750 Protein denotes p53
T5196 10714-10717 Protein denotes p53
T5195 10658-10662 Protein denotes WWOX
T5194 10500-10504 Protein denotes WWOX
T5193 10456-10460 Protein denotes Wwox
T5192 10232-10236 Protein denotes Wwox
T2198 6382-6390 Gene_expression denotes positive
T2197 5824-5833 Negative_regulation denotes inhibitor
T2196 5843-5852 Negative_regulation denotes knockdown
T2195 4383-4392 Regulation denotes regulates
T2194 4044-4057 Positive_regulation denotes overexpressed
T2193 3964-3970 Negative_regulation denotes blocks
T2192 3984-3994 Gene_expression denotes expression
T2191 3914-3922 Positive_regulation denotes increase
T2190 3540-3551 Positive_regulation denotes contributes
T2189 3528-3532 Negative_regulation denotes loss
T2188 3506-3516 Gene_expression denotes expression
T2187 2859-2871 Positive_regulation denotes participates
T2186 2586-2591 Positive_regulation denotes leads
T2185 2563-2572 Negative_regulation denotes inhibitor
T2184 2514-2524 Negative_regulation denotes inhibition
T2183 6524-6529 Protein denotes CD133
T2182 6376-6381 Protein denotes CD133
T2181 5837-5842 Protein denotes STAT3
T2180 5818-5823 Protein denotes STAT3
T2179 5639-5643 Protein denotes MGMT
T2178 5533-5538 Protein denotes IFN-β
T2177 5519-5531 Protein denotes Interferon-β
T2176 5047-5051 Protein denotes MGMT
T2175 4393-4396 Protein denotes p53
T2174 4177-4188 Protein denotes MicroRNA-21
T2173 4098-4107 Protein denotes caspase-3
T2172 4082-4087 Protein denotes Bcl-2
T2171 4078-4081 Protein denotes Bax
T2170 4058-4069 Protein denotes microRNA-21
T2169 3971-3975 Protein denotes MGMT
T2168 3926-3930 Protein denotes MGMT
T2167 3829-3833 Protein denotes MGMT
T2166 3520-3524 Protein denotes MGMT
T2165 3260-3264 Protein denotes MGMT
T2164 3158-3162 Protein denotes MGMT
T2163 3118-3156 Protein denotes O6-methylguanine-DNA methyltransferase
T2162 2946-2951 Protein denotes MAPO2
T2161 2844-2852 Protein denotes C1orf201
T2160 2837-2842 Protein denotes MAPO2
T2159 2557-2562 Protein denotes Bcl-2
T2158 2542-2547 Protein denotes Bcl-2
T424 934-944 Positive_regulation denotes triggering
T423 1003-1013 Negative_regulation denotes deficiency
T422 950-960 Positive_regulation denotes activation
T421 877-885 Regulation denotes modulate
T420 693-697 Binding denotes bind
T419 597-604 Positive_regulation denotes induces
T418 553-563 Gene_expression denotes expression
T417 374-378 Negative_regulation denotes Loss
T416 392-402 Gene_expression denotes expression
T414 988-991 Protein denotes p53
T413 945-949 Protein denotes WWOX
T412 912-916 Protein denotes WWOX
T411 859-862 Protein denotes p53
T410 793-797 Protein denotes WWOX
T409 785-788 Protein denotes p53
T408 722-725 Protein denotes p53
T407 665-669 Protein denotes WWOX
T406 577-581 Protein denotes WWOX
T405 660-663 Protein denotes p53
T404 382-386 Protein denotes WWOX
T403 301-305 Protein denotes WOX1
T402 294-297 Protein denotes FOR
T401 288-292 Protein denotes WWOX
T400 252-287 Protein denotes WW domain-containing oxidoreductase
T399 106-109 Protein denotes p53
R212 T397 T415 themeOf WWOX,Alterations
R213 T398 T415 themeOf p53,Alterations
R214 T404 T416 themeOf WWOX,expression
R215 T406 T418 themeOf WWOX,expression
R216 T407 T420 themeOf WWOX,bind
R217 T408 T420 themeOf p53,bind
R218 T411 T421 causeOf p53,modulate
R219 T412 T421 themeOf WWOX,modulate
R220 T413 T422 themeOf WWOX,activation
R221 T414 T423 themeOf p53,deficiency
R222 T416 T417 themeOf expression,Loss
R223 T418 T419 themeOf expression,induces
R224 T422 T424 themeOf activation,triggering
R225 T423 T424 causeOf deficiency,triggering
R1475 T2158 T2184 themeOf Bcl-2,inhibition
R1489 T2159 T2185 themeOf Bcl-2,inhibitor
R1491 T2160 T2187 themeOf MAPO2,participates
R1493 T2161 T2187 themeOf C1orf201,participates
R1494 T2166 T2188 themeOf MGMT,expression
R1495 T2168 T2191 themeOf MGMT,increase
R1496 T2169 T2192 themeOf MGMT,expression
R1497 T2170 T2194 themeOf microRNA-21,overexpressed
R1498 T2175 T2195 themeOf p53,regulates
R1499 T2180 T2197 themeOf STAT3,inhibitor
R1500 T2181 T2196 themeOf STAT3,knockdown
R1501 T2182 T2198 themeOf CD133,positive
R1503 T2184 T2186 themeOf inhibition,leads
R1504 T2188 T2189 themeOf expression,loss
R1505 T2188 T2190 themeOf expression,contributes
R1507 T2192 T2193 themeOf expression,blocks
R1508 T2196 T2197 causeOf knockdown,inhibitor
R3639 T5178 T5223 themeOf WWOX,Expression
R3640 T5179 T5225 themeOf WWOX,Restoration
R3641 T5188 T5226 themeOf WWOX,overexpressed
R3642 T5188 T5227 themeOf WWOX,binds
R3643 T5188 T5228 themeOf WWOX,relocation
R3644 T5188 T5227 themeOf WWOX,binds
R3645 T5189 T5227 themeOf AP-2,binds
R3647 T5191 T5227 themeOf c-Jun,binds
R3648 T5193 T5229 themeOf Wwox,blocking
R3649 T5194 T5230 themeOf WWOX,activated
R3650 T5194 T5231 themeOf WWOX,binds
R3651 T5195 T5232 themeOf WWOX,Activated
R3652 T5195 T5233 themeOf WWOX,interacts
R3653 T5196 T5233 themeOf p53,interacts
R3654 T5196 T5234 themeOf p53,46-phosphorylated
R3655 T5196 T5235 causeOf p53,stabilizes
R3656 T5197 T5235 themeOf p53,stabilizes
R3657 T5198 T5236 themeOf WWOX,binds
R3658 T5200 T5237 themeOf WWOX,overexpressed
R3659 T5200 T5238 themeOf WWOX,sequesters
R3660 T5201 T5238 themeOf Dvl-2,sequesters
R3663 T5203 T5239 themeOf WWOX,Overexpressed
R3665 T5204 T5240 causeOf WWOX,down-regulating
R3666 T5204 T5240 causeOf WWOX,down-regulating
R3667 T5206 T5240 themeOf Bcl-2,down-regulating
R3668 T5207 T5240 themeOf Bcl-xL,down-regulating
R3669 T5208 T5241 themeOf p53,up-regulating
R3670 T5211 T5242 themeOf WWOX,phosphorylation
R3672 T5212 T5243 themeOf WWOX,binds
R3673 T5213 T5244 themeOf WWOX,induces
R3674 T5213 T5245 themeOf WWOX,translocate
R3675 T5214 T5246 themeOf WWOX,expression
R3676 T5215 T5247 themeOf procaspase-3,activation
R3678 T5216 T5247 themeOf procaspase-9,activation
R3679 T5217 T5248 themeOf WWOX,phosphorylation
R3680 T5218 T5250 themeOf WWOX,binding
R3681 T5218 T5250 themeOf WWOX,binding
R3682 T5219 T5250 themeOf Hyal-2,binding
R3683 T5219 T5250 themeOf Hyal-2,binding
R3684 T5220 T5251 themeOf Ezrin,Phospho
R3685 T5220 T5250 themeOf Ezrin,binding
R3686 T5220 T5250 themeOf Ezrin,binding
R3687 T5221 T5252 themeOf Transforming growth factor β1,binds
R3688 T5222 T5252 themeOf Hyal-2,binds
R3689 T5223 T5224 themeOf Expression,altered
R3697 T5245 T5244 themeOf translocate,induces
R3698 T5248 T5249 themeOf phosphorylation,ectopic
R4967 T7070 T7086 themeOf p53,Activated
R4968 T7073 T7087 themeOf BCL-2,inhibiting
R4969 T7083 T7088 themeOf smooth muscle α-actin,expression
R4970 T7084 T7088 themeOf collagens IIα1,expression
R4971 T7085 T7088 themeOf VIα1,expression
R4972 T7088 T7089 themeOf expression,regulating
R4973 T7088 T7089 themeOf expression,regulating
R4974 T7088 T7089 themeOf expression,regulating
R5448 T7856 T7877 themeOf p53,expression
R5449 T7857 T7878 themeOf p53,localized
R5450 T7858 T7878 themeOf Δ133p53,localized
R5451 T7859 T7878 themeOf p53β,localized
R5452 T7860 T7879 themeOf p53γ,localized
R5453 T7861 T7879 themeOf Δ133p53β,localized
R5454 T7862 T7880 themeOf Δ133p53γ,localized
R5455 T7863 T7881 themeOf p53β,Co-transfection
R5456 T7865 T7883 themeOf p53,co-expression
R5457 T7866 T7883 themeOf Δ133p53,co-expression
R5458 T7868 T7881 themeOf p53,Co-transfection
R5459 T7871 T7884 themeOf Δ133p53β,Co-expression
R5460 T7872 T7884 themeOf Δ133p53γ,Co-expression
R5461 T7873 T7884 themeOf p53,Co-expression
R5462 T7876 T7885 themeOf Bax,affect
R5463 T7876 T7885 themeOf Bax,affect
R5464 T7876 T7885 themeOf Bax,affect
R5465 T7881 T7882 themeOf Co-transfection,increases
R5466 T7881 T7882 themeOf Co-transfection,increases
R5467 T7884 T7885 causeOf Co-expression,affect
R5468 T7884 T7885 causeOf Co-expression,affect
R5469 T7884 T7885 causeOf Co-expression,affect
R6152 T8944 T8968 themeOf p53,Loss
R6153 T8946 T8969 themeOf p53,reduce
R6154 T8947 T8970 themeOf WWOX,expression
R6155 T8948 T8971 themeOf WWOX,downregulation
R6156 T8949 T8973 themeOf WWOX,overexpressed
R6157 T8951 T8975 themeOf p53,expressing
R6158 T8952 T8974 themeOf WWOX,ectopic
R6159 T8955 T8977 themeOf p53,interactions
R6160 T8955 T8978 themeOf p53,gain-of-function
R6161 T8956 T8977 themeOf WWOX,interactions
R6162 T8956 T8978 themeOf WWOX,gain-of-function
R6163 T8957 T8979 themeOf WWOX,Activated
R6164 T8957 T8980 themeOf WWOX,binds
R6165 T8958 T8980 themeOf p53,binds
R6166 T8958 T8981 themeOf p53,phosphorylation
R6167 T8960 T8982 themeOf WWOX,binding
R6168 T8963 T8983 themeOf p53,bind
R6169 T8964 T8983 themeOf WWOX,bind
R6170 T8967 T8984 themeOf p53,expressing
R6171 T8970 T8972 themeOf expression,Altered
R6172 T8974 T8976 causeOf ectopic,effect
R6173 T8975 T8976 themeOf expressing,effect
R6174 T8977 T8978 themeOf interactions,gain-of-function
R7581 T11089 T11132 themeOf WWOX,Binding
R7582 T11089 T11132 themeOf WWOX,Binding
R7583 T11090 T11132 themeOf p53,Binding
R7584 T11091 T11133 themeOf WWOX,binds
R7585 T11092 T11134 themeOf WWOX,activated
R7586 T11093 T11135 themeOf WWOX,inducing
R7587 T11095 T11136 themeOf p53,interacts
R7588 T11096 T11136 themeOf WWOX,interacts
R7589 T11097 T11137 themeOf p53,binding
R7590 T11099 T11138 themeOf p53,interfere
R7591 T11100 T11139 themeOf p53,upregulated
R7592 T11101 T11139 themeOf WWOX,upregulated
R7593 T11103 T11139 themeOf PTEN,upregulated
R7594 T11108 T11140 themeOf CD44,interacting
R7595 T11109 T11141 themeOf WWOX,expression
R7596 T11110 T11143 themeOf WWOX,loss
R7597 T11111 T11144 themeOf TIAF1,expression
R7598 T11112 T11144 themeOf p53,expression
R7599 T11113 T11144 themeOf WWOX,expression
R7600 T11116 T11145 themeOf WWOX,negative
R7601 T11117 T11146 themeOf WWOX,positive
R7602 T11118 T11147 themeOf WWOX,negative
R7603 T11119 T11148 themeOf WWOX,positive
R7604 T11120 T11149 themeOf WWOX,negative
R7605 T11121 T11150 themeOf WWOX,expressing
R7606 T11122 T11151 themeOf WWOX,expression
R7607 T11122 T11150 themeOf WWOX,expressing
R7608 T11123 T11152 themeOf WWOX,negative
R7609 T11124 T11153 themeOf Wwox,knockout
R7610 T11126 T11154 themeOf Wwox,expression
R7611 T11131 T11156 themeOf WWOX,deficiency
R7612 T11137 T11138 themeOf binding,interfere
R7613 T11141 T11142 themeOf expression,lack
R7614 T11154 T11155 themeOf expression,induces
R7615 T11156 T11157 themeOf deficiency,effects
R9291 T13392 T13414 themeOf WWOX,phosphorylated
R9292 T13392 T13415 themeOf WWOX,binds
R9293 T13393 T13415 themeOf p53,binds
R9294 T13394 T13416 themeOf WWOX,binding
R9295 T13394 T13416 themeOf WWOX,binding
R9296 T13396 T13416 themeOf c-Jun,binding
R9297 T13397 T13416 themeOf ERBB4,binding
R9298 T13398 T13417 themeOf Tau,binds
R9299 T13399 T13417 themeOf WWOX,binds
R9300 T13400 T13418 themeOf WWOX,binding
R9301 T13400 T13419 themeOf WWOX,import
R9302 T13400 T13420 causeOf WWOX,inhibiting
R9303 T13401 T13421 themeOf WWOX,released
R9304 T13401 T13422 themeOf WWOX,translocates
R9305 T13402 T13423 themeOf WWOX,recruited
R9306 T13403 T13424 themeOf Hyal-2,association
R9307 T13404 T13424 themeOf Ezrin,association
R9308 T13404 T13425 themeOf Ezrin,phospho
R9309 T13419 T13420 themeOf import,inhibiting
R9906 T14424 T14440 themeOf p53,DNA-binding
R9907 T14424 T14441 themeOf p53,localization
R9908 T14425 T14442 themeOf p53,deletion
R9909 T14429 T14443 themeOf p53,expressing
R9910 T14430 T14444 themeOf p53,binds
R9911 T14430 T14445 themeOf p53,antagonizes
R9912 T14431 T14444 themeOf WWOX,binds
R9913 T14431 T14445 causeOf WWOX,antagonizes
R9914 T14432 T14446 themeOf p53,interactions
R9915 T14433 T14446 themeOf WWOX,interactions
R9916 T14435 T14447 themeOf p53,expressing
R9917 T14436 T14448 themeOf WWOX,binds
R9918 T14437 T14448 themeOf p53,binds
R9919 T14438 T14449 themeOf WWOX,induction
R9920 T14439 T14450 themeOf p53,expressing
R9921 T14449 T14451 themeOf induction,ectopic

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T447 17-21 Protein denotes WWOX
T448 26-29 Protein denotes p53
T465 30-41 Regulation denotes Alterations
T11312 20073-20084 Binding denotes interacting
T14505 14604-14611 Positive_regulation denotes ectopic
T14504 14653-14663 Gene_expression denotes expressing
T14503 14617-14626 Positive_regulation denotes induction
T14502 14559-14564 Binding denotes binds
T14501 14488-14494 Positive_regulation denotes induce
T14500 14475-14482 Negative_regulation denotes ectopic
T14499 14519-14529 Gene_expression denotes expressing
T14498 14392-14404 Binding denotes interactions
T14497 14248-14255 Negative_regulation denotes ectopic
T14496 14284-14295 Negative_regulation denotes antagonizes
T14495 14261-14266 Binding denotes binds
T14494 14195-14205 Gene_expression denotes expressing
T14493 14664-14667 Protein denotes p53
T14492 14612-14616 Protein denotes WWOX
T14491 14565-14568 Protein denotes p53
T14490 14554-14558 Protein denotes WWOX
T14489 14515-14518 Protein denotes p53
T14488 14483-14487 Protein denotes WWOX
T14487 14437-14441 Protein denotes WWOX
T14486 14420-14423 Protein denotes p53
T14485 14256-14260 Protein denotes WWOX
T14484 14296-14299 Protein denotes p53
T14483 14227-14230 Protein denotes p53
T14482 14151-14155 Protein denotes WWOX
T14481 14104-14107 Protein denotes p53
T14480 14095-14099 Protein denotes WWOX
T14479 14031-14034 Protein denotes p53
T14478 13772-13775 Protein denotes p53
T14477 13728-13732 Protein denotes WWOX
T14476 13720-13723 Protein denotes p53
T13496 8946-8951 Binding denotes binds
T13495 8857-8864 Phosphorylation denotes phospho
T13494 8795-8804 Binding denotes recruited
T13493 8829-8840 Binding denotes association
T13492 8730-8742 Localization denotes translocates
T13491 8716-8724 Localization denotes released
T13490 8620-8626 Localization denotes import
T13489 8581-8588 Binding denotes binding
T13488 8597-8607 Negative_regulation denotes inhibiting
T13487 8494-8499 Binding denotes binds
T13486 8407-8414 Binding denotes binding
T13485 8290-8295 Binding denotes binds
T13484 8154-8168 Phosphorylation denotes phosphorylated
T13483 8182-8187 Binding denotes binds
T13482 9118-9144 Protein denotes hyaluronoglucosaminidase 2
T13481 9110-9116 Protein denotes Hyal-2
T13480 9073-9108 Protein denotes activated Cdc42-associated kinase 1
T13479 9067-9071 Protein denotes Ack1
T13478 8952-8958 Protein denotes Hyal-2
T13477 8941-8945 Protein denotes WWOX
T13476 8933-8939 Protein denotes TGF-β1
T13475 8910-8916 Protein denotes TGF-β1
T13474 8872-8878 Protein denotes Hyal-2
T13473 8865-8870 Protein denotes Ezrin
T13472 8846-8852 Protein denotes Hyal-2
T13471 8787-8791 Protein denotes WWOX
T13470 8725-8729 Protein denotes WWOX
T13469 8524-8528 Protein denotes WWOX
T13468 8489-8493 Protein denotes WWOX
T13467 8500-8503 Protein denotes Tau
T13466 8367-8372 Protein denotes ERBB4
T13465 8356-8361 Protein denotes c-Jun
T13464 8349-8354 Protein denotes RUNX2
T13463 8280-8284 Protein denotes WWOX
T13462 8188-8191 Protein denotes p53
T13461 8146-8150 Protein denotes WWOX
T13460 7575-7579 Protein denotes WWOX
T13459 7533-7537 Protein denotes WWOX
T12530 22781-22785 Protein denotes WWOX
T12529 22773-22776 Protein denotes p53
T11328 22595-22605 Negative_regulation denotes deficiency
T11327 21998-22008 Gene_expression denotes expression
T11326 22009-22016 Positive_regulation denotes induces
T11325 21627-21635 Negative_regulation denotes knockout
T11324 21468-21476 Gene_expression denotes negative
T11323 21305-21313 Gene_expression denotes negative
T11322 21407-21417 Gene_expression denotes expression
T11321 21372-21382 Gene_expression denotes expressing
T11320 21271-21279 Gene_expression denotes positive
T11319 21173-21181 Gene_expression denotes positive
T11318 21124-21132 Gene_expression denotes negative
T11317 21229-21237 Gene_expression denotes negative
T11316 20519-20529 Gene_expression denotes expression
T11315 20388-20392 Negative_regulation denotes loss
T11314 20325-20335 Gene_expression denotes expression
T11313 20312-20316 Negative_regulation denotes lack
T11311 19662-19673 Negative_regulation denotes counteracts
T11310 19361-19372 Positive_regulation denotes upregulated
T11309 19027-19034 Binding denotes binding
T11308 19076-19085 Negative_regulation denotes interfere
T11307 18845-18854 Binding denotes interacts
T11306 18639-18648 Positive_regulation denotes activated
T11305 17848-17853 Binding denotes binds
T11304 17741-17748 Binding denotes Binding
T11303 22590-22594 Protein denotes WWOX
T11302 22499-22503 Protein denotes WWOX
T11301 22424-22428 Protein denotes WWOX
T11300 22416-22419 Protein denotes p53
T11299 22181-22185 Protein denotes WWOX
T11298 21988-21992 Protein denotes Wwox
T11297 21823-21827 Protein denotes Wwox
T11296 21622-21626 Protein denotes Wwox
T11295 21463-21467 Protein denotes WWOX
T11294 21402-21406 Protein denotes WWOX
T11293 21367-21371 Protein denotes WWOX
T11292 21300-21304 Protein denotes WWOX
T11291 21266-21270 Protein denotes WWOX
T11290 21224-21228 Protein denotes WWOX
T11289 21168-21172 Protein denotes WWOX
T11288 21119-21123 Protein denotes WWOX
T11287 21067-21071 Protein denotes WWOX
T11286 20876-20880 Protein denotes Wwox
T11285 20586-20590 Protein denotes WWOX
T11284 20577-20580 Protein denotes p53
T11283 20533-20538 Protein denotes TIAF1
T11282 20396-20400 Protein denotes WWOX
T11281 20320-20324 Protein denotes WWOX
T11280 20050-20054 Protein denotes CD44
T11279 19903-19907 Protein denotes mTOR
T11278 19898-19901 Protein denotes Akt
T11277 19706-19709 Protein denotes p53
T11276 19657-19661 Protein denotes WWOX
T11275 19321-19325 Protein denotes PTEN
T11274 19314-19319 Protein denotes Smad4
T11273 19308-19312 Protein denotes WWOX
T11272 19303-19306 Protein denotes p53
T11271 19126-19129 Protein denotes p53
T11270 19117-19121 Protein denotes WWOX
T11269 19023-19026 Protein denotes p53
T11268 18860-18864 Protein denotes WWOX
T11267 18828-18831 Protein denotes p53
T11266 18756-18759 Protein denotes p53
T11265 18692-18696 Protein denotes WWOX
T11264 18631-18635 Protein denotes WWOX
T11263 17843-17847 Protein denotes WWOX
T11262 17774-17777 Protein denotes p53
T11261 17762-17766 Protein denotes WWOX
T11260 17685-17689 Protein denotes WWOX
T9060 17597-17607 Gene_expression denotes expressing
T9059 17490-17494 Binding denotes bind
T9058 17211-17218 Binding denotes binding
T9057 17081-17096 Phosphorylation denotes phosphorylation
T9056 17050-17055 Binding denotes binds
T9055 17035-17044 Positive_regulation denotes Activated
T9054 16794-16805 Regulation denotes independent
T9053 16714-16721 Positive_regulation denotes induces
T9052 16671-16681 Gene_expression denotes expressing
T9051 16632-16639 Negative_regulation denotes ectopic
T9050 16652-16658 Regulation denotes effect
T9049 16468-16481 Positive_regulation denotes overexpressed
T9048 16325-16339 Negative_regulation denotes downregulation
T9047 16274-16281 Regulation denotes Altered
T9046 16287-16297 Gene_expression denotes expression
T9045 16064-16068 Negative_regulation denotes Loss
T9044 16153-16162 Positive_regulation denotes increases
T9043 17608-17611 Protein denotes p53
T9042 17568-17572 Protein denotes WWOX
T9041 17526-17530 Protein denotes WWOX
T9040 17503-17507 Protein denotes WWOX
T9039 17470-17473 Protein denotes p53
T9038 17334-17338 Protein denotes WWOX
T9037 17318-17321 Protein denotes p53
T9036 17240-17244 Protein denotes WWOX
T9035 17203-17209 Protein denotes Δ40p53
T9034 17066-17069 Protein denotes p53
T9033 17045-17049 Protein denotes WWOX
T9032 17029-17033 Protein denotes WWOX
T9031 17013-17016 Protein denotes p53
T9030 16784-16793 Protein denotes caspase-3
T9029 16709-16713 Protein denotes WWOX
T9028 16640-16644 Protein denotes WWOX
T9027 16692-16695 Protein denotes p53
T9026 16552-16555 Protein denotes p53
T9025 16482-16486 Protein denotes WWOX
T9024 16343-16347 Protein denotes WWOX
T9023 16282-16286 Protein denotes WWOX
T9022 16205-16208 Protein denotes p53
T9021 16149-16152 Protein denotes p53
T9020 16083-16086 Protein denotes p53
T9019 15852-15855 Protein denotes p53
T7943 15678-15691 Gene_expression denotes Co-expression
T7942 15586-15595 Regulation denotes regulates
T7941 15601-15611 Gene_expression denotes expression
T7940 15471-15484 Gene_expression denotes co-expression
T7939 15397-15412 Gene_expression denotes Co-transfection
T7938 15346-15355 Localization denotes localized
T7937 15294-15303 Localization denotes localized
T7936 15200-15209 Localization denotes localized
T7935 15077-15087 Gene_expression denotes expression
T7934 15781-15784 Protein denotes Bax
T7933 15773-15776 Protein denotes p21
T7932 15741-15744 Protein denotes p53
T7931 15721-15724 Protein denotes p53
T7930 15707-15715 Protein denotes Δ133p53γ
T7929 15695-15703 Protein denotes Δ133p53β
T7928 15615-15618 Protein denotes p53
T7927 15563-15570 Protein denotes Δ133p53
T7926 15416-15419 Protein denotes p53
T7925 15516-15519 Protein denotes p53
T7924 15497-15504 Protein denotes Δ133p53
T7923 15488-15491 Protein denotes p53
T7922 15439-15442 Protein denotes p53
T7921 15424-15428 Protein denotes p53β
T7920 15334-15342 Protein denotes Δ133p53γ
T7919 15281-15289 Protein denotes Δ133p53β
T7918 15272-15276 Protein denotes p53γ
T7917 15191-15195 Protein denotes p53β
T7916 15178-15185 Protein denotes Δ133p53
T7915 15173-15176 Protein denotes p53
T7914 15091-15094 Protein denotes p53
T7913 14874-14877 Protein denotes p53
T7126 13591-13601 Gene_expression denotes expression
T7125 13576-13586 Regulation denotes regulating
T7124 13283-13293 Negative_regulation denotes inhibiting
T7123 12874-12883 Positive_regulation denotes Activated
T7122 13668-13672 Protein denotes VIα1
T7121 13649-13663 Protein denotes collagens IIα1
T7120 13605-13626 Protein denotes smooth muscle α-actin
T7119 13526-13529 Protein denotes p53
T7118 13348-13351 Protein denotes p53
T7117 13262-13268 Protein denotes SCOTIN
T7116 13256-13260 Protein denotes PUMA
T7115 13251-13254 Protein denotes BAX
T7114 13183-13186 Protein denotes p53
T7113 13176-13181 Protein denotes miR34
T7112 13159-13162 Protein denotes p21
T7111 13062-13065 Protein denotes p53
T7110 13317-13322 Protein denotes BCL-2
T7109 13274-13277 Protein denotes FAS
T7108 13016-13019 Protein denotes p53
T7107 12884-12887 Protein denotes p53
T5410 12668-12673 Binding denotes binds
T5409 12547-12554 Binding denotes binding
T5408 12500-12508 Positive_regulation denotes anchored
T5407 12344-12359 Phosphorylation denotes phosphorylation
T5406 12331-12338 Positive_regulation denotes ectopic
T5405 12323-12330 Positive_regulation denotes induces
T5404 12146-12156 Gene_expression denotes expression
T5403 12179-12186 Positive_regulation denotes induces
T5402 12232-12239 Positive_regulation denotes induces
T5401 12217-12227 Positive_regulation denotes activation
T5400 11924-11931 Positive_regulation denotes induces
T5399 11940-11951 Localization denotes translocate
T5398 11807-11812 Binding denotes binds
T5397 11650-11665 Phosphorylation denotes phosphorylation
T5396 11368-11383 Negative_regulation denotes down-regulating
T5395 11425-11438 Positive_regulation denotes up-regulating
T5394 11115-11122 Positive_regulation denotes induces
T5393 11096-11109 Positive_regulation denotes Overexpressed
T5392 10973-10983 Negative_regulation denotes sequesters
T5391 10954-10967 Positive_regulation denotes overexpressed
T5390 10812-10817 Binding denotes binds
T5389 10674-10683 Binding denotes interacts
T5388 10648-10657 Positive_regulation denotes Activated
T5387 10696-10713 Phosphorylation denotes 46-phosphorylated
T5386 10736-10746 Negative_regulation denotes stabilizes
T5385 10552-10557 Binding denotes binds
T5384 10508-10517 Positive_regulation denotes activated
T5383 10388-10396 Negative_regulation denotes blocking
T5382 10040-10053 Positive_regulation denotes overexpressed
T5381 10132-10142 Localization denotes relocation
T5380 10059-10064 Binding denotes binds
T5379 10112-10117 Negative_regulation denotes block
T5378 9837-9845 Binding denotes interact
T5377 9638-9649 Positive_regulation denotes Restoration
T5376 9249-9256 Regulation denotes altered
T5375 9260-9264 Negative_regulation denotes lost
T5374 9220-9230 Gene_expression denotes Expression
T5373 12674-12680 Protein denotes Hyal-2
T5372 12638-12667 Protein denotes Transforming growth factor β1
T5371 12612-12617 Protein denotes Ezrin
T5370 12574-12580 Protein denotes Hyal-2
T5369 12492-12496 Protein denotes WWOX
T5368 12339-12343 Protein denotes WWOX
T5367 12204-12216 Protein denotes procaspase-9
T5366 12187-12199 Protein denotes procaspase-3
T5365 12160-12164 Protein denotes WWOX
T5364 11932-11936 Protein denotes WWOX
T5363 11802-11806 Protein denotes WWOX
T5362 11635-11639 Protein denotes WWOX
T5361 11527-11530 Protein denotes p53
T5360 11481-11485 Protein denotes WWOX
T5359 11449-11452 Protein denotes p53
T5358 11414-11420 Protein denotes Bcl-xL
T5357 11404-11409 Protein denotes Bcl-2
T5356 11343-11364 Protein denotes tumor necrosis factor
T5355 11303-11307 Protein denotes WWOX
T5354 11110-11114 Protein denotes WWOX
T5353 11026-11031 Protein denotes Dvl-2
T5352 10984-10989 Protein denotes Dvl-2
T5351 10968-10972 Protein denotes WWOX
T5350 10877-10886 Protein denotes β-catenin
T5349 10807-10811 Protein denotes WWOX
T5348 10747-10750 Protein denotes p53
T5347 10714-10717 Protein denotes p53
T5346 10658-10662 Protein denotes WWOX
T5345 10500-10504 Protein denotes WWOX
T5344 10456-10460 Protein denotes Wwox
T5343 10232-10236 Protein denotes Wwox
T5342 10102-10107 Protein denotes c-Jun
T5341 10093-10096 Protein denotes p73
T5340 10087-10091 Protein denotes AP-2
T5339 10054-10058 Protein denotes WWOX
T5338 9936-9941 Protein denotes RUNX4
T5337 9929-9934 Protein denotes c-Jun
T5336 9921-9927 Protein denotes SIMPLE
T5335 9914-9919 Protein denotes Ezrin
T5334 9907-9912 Protein denotes ErbB4
T5333 9902-9905 Protein denotes p73
T5332 9895-9900 Protein denotes AP-2γ
T5331 9828-9832 Protein denotes WWOX
T5330 9653-9657 Protein denotes WWOX
T5329 9234-9238 Protein denotes WWOX
T5328 7300-7304 Protein denotes WWOX
T5327 7024-7028 Protein denotes WWOX
T5326 6899-6903 Protein denotes Wwox
T5325 6894-6898 Protein denotes WWOX
T5324 6859-6863 Protein denotes WOX1
T5323 6851-6854 Protein denotes FOR
T5322 6845-6849 Protein denotes WWOX
T5321 6799-6834 Protein denotes WW domain-containing oxidoreductase
T5320 6712-6716 Protein denotes WWOX
T5319 6704-6707 Protein denotes p53
T2262 3506-3516 Gene_expression denotes expression
T2261 3540-3551 Positive_regulation denotes contributes
T2260 2514-2524 Negative_regulation denotes inhibition
T2259 6524-6529 Protein denotes CD133
T2258 6376-6381 Protein denotes CD133
T2257 5837-5842 Protein denotes STAT3
T2256 5818-5823 Protein denotes STAT3
T2255 5639-5643 Protein denotes MGMT
T2254 5533-5538 Protein denotes IFN-β
T2253 5519-5531 Protein denotes Interferon-β
T2252 5047-5051 Protein denotes MGMT
T2251 4393-4396 Protein denotes p53
T2250 4177-4188 Protein denotes MicroRNA-21
T2249 4098-4107 Protein denotes caspase-3
T2248 4082-4087 Protein denotes Bcl-2
T2247 4078-4081 Protein denotes Bax
T2246 4058-4069 Protein denotes microRNA-21
T2245 3971-3975 Protein denotes MGMT
T2244 3926-3930 Protein denotes MGMT
T2243 3829-3833 Protein denotes MGMT
T2242 3520-3524 Protein denotes MGMT
T2241 3260-3264 Protein denotes MGMT
T2240 3158-3162 Protein denotes MGMT
T2239 3118-3156 Protein denotes O6-methylguanine-DNA methyltransferase
T2238 2946-2951 Protein denotes MAPO2
T2237 2844-2852 Protein denotes C1orf201
T2236 2837-2842 Protein denotes MAPO2
T2235 2557-2562 Protein denotes Bcl-2
T2234 2542-2547 Protein denotes Bcl-2
T2270 6382-6390 Gene_expression denotes positive
T2269 5824-5833 Negative_regulation denotes inhibitor
T2268 5843-5852 Negative_regulation denotes knockdown
T2267 5599-5607 Positive_regulation denotes increase
T2266 4070-4077 Negative_regulation denotes reduces
T2265 4044-4057 Positive_regulation denotes overexpressed
T2264 3964-3970 Negative_regulation denotes blocks
T2263 3984-3994 Gene_expression denotes expression
T473 950-960 Positive_regulation denotes activation
T472 934-944 Positive_regulation denotes triggering
T471 1003-1013 Negative_regulation denotes deficiency
T470 693-697 Binding denotes bind
T469 553-563 Gene_expression denotes expression
T468 597-604 Positive_regulation denotes induces
T467 374-378 Negative_regulation denotes Loss
T466 392-402 Gene_expression denotes expression
T464 988-991 Protein denotes p53
T463 945-949 Protein denotes WWOX
T462 912-916 Protein denotes WWOX
T461 859-862 Protein denotes p53
T460 793-797 Protein denotes WWOX
T459 785-788 Protein denotes p53
T458 722-725 Protein denotes p53
T457 665-669 Protein denotes WWOX
T456 577-581 Protein denotes WWOX
T455 660-663 Protein denotes p53
T454 382-386 Protein denotes WWOX
T453 301-305 Protein denotes WOX1
T452 294-297 Protein denotes FOR
T451 288-292 Protein denotes WWOX
T450 252-287 Protein denotes WW domain-containing oxidoreductase
T449 106-109 Protein denotes p53
R230 T448 T465 themeOf p53,Alterations
R231 T454 T466 themeOf WWOX,expression
R232 T456 T469 themeOf WWOX,expression
R233 T457 T470 themeOf WWOX,bind
R234 T463 T473 themeOf WWOX,activation
R235 T464 T471 themeOf p53,deficiency
R236 T466 T467 themeOf expression,Loss
R237 T469 T468 themeOf expression,induces
R238 T473 T472 themeOf activation,triggering
R1520 T2234 T2260 themeOf Bcl-2,inhibition
R1522 T2242 T2262 themeOf MGMT,expression
R1524 T2245 T2263 themeOf MGMT,expression
R1525 T2246 T2265 themeOf microRNA-21,overexpressed
R1527 T2249 T2266 themeOf caspase-3,reduces
R1528 T2253 T2267 themeOf Interferon-β,increase
R1531 T2256 T2269 themeOf STAT3,inhibitor
R1535 T2256 T2268 themeOf STAT3,knockdown
R1536 T2257 T2268 themeOf STAT3,knockdown
R1539 T2258 T2270 themeOf CD133,positive
R1542 T2262 T2261 themeOf expression,contributes
R1543 T2263 T2264 themeOf expression,blocks
R3700 T5389 T5386 causeOf interacts,stabilizes
R3701 T5329 T5374 themeOf WWOX,Expression
R3702 T5401 T5403 themeOf activation,induces
R3703 T5330 T5377 themeOf WWOX,Restoration
R3704 T5331 T5378 themeOf WWOX,interact
R3705 T5331 T5378 themeOf WWOX,interact
R3706 T5331 T5378 themeOf WWOX,interact
R3707 T5331 T5378 themeOf WWOX,interact
R3708 T5331 T5378 themeOf WWOX,interact
R3709 T5331 T5378 themeOf WWOX,interact
R3710 T5331 T5378 themeOf WWOX,interact
R3711 T5332 T5378 themeOf AP-2γ,interact
R3712 T5333 T5378 themeOf p73,interact
R3713 T5334 T5378 themeOf ErbB4,interact
R3714 T5335 T5378 themeOf Ezrin,interact
R3715 T5336 T5378 themeOf SIMPLE,interact
R3716 T5337 T5378 themeOf c-Jun,interact
R3717 T5338 T5378 themeOf RUNX4,interact
R3718 T5339 T5381 themeOf WWOX,relocation
R3719 T5339 T5382 themeOf WWOX,overexpressed
R3720 T5339 T5380 themeOf WWOX,binds
R3721 T5339 T5380 themeOf WWOX,binds
R3722 T5339 T5380 themeOf WWOX,binds
R3723 T5340 T5380 themeOf AP-2,binds
R3724 T5341 T5380 themeOf p73,binds
R3725 T5342 T5380 themeOf c-Jun,binds
R3726 T5344 T5383 themeOf Wwox,blocking
R3727 T5345 T5385 themeOf WWOX,binds
R3728 T5345 T5384 themeOf WWOX,activated
R3729 T5346 T5388 themeOf WWOX,Activated
R3730 T5346 T5389 themeOf WWOX,interacts
R3731 T5347 T5389 themeOf p53,interacts
R3732 T5347 T5387 themeOf p53,46-phosphorylated
R3733 T5401 T5403 themeOf activation,induces
R3734 T5348 T5386 themeOf p53,stabilizes
R3735 T5404 T5402 themeOf expression,induces
R3736 T5349 T5390 themeOf WWOX,binds
R3737 T5351 T5391 themeOf WWOX,overexpressed
R3738 T5352 T5392 themeOf Dvl-2,sequesters
R3739 T5404 T5403 themeOf expression,induces
R3740 T5354 T5393 themeOf WWOX,Overexpressed
R3741 T5354 T5394 themeOf WWOX,induces
R3742 T5407 T5405 themeOf phosphorylation,induces
R3743 T5355 T5396 causeOf WWOX,down-regulating
R3744 T5355 T5396 causeOf WWOX,down-regulating
R3745 T5357 T5396 themeOf Bcl-2,down-regulating
R3746 T5358 T5396 themeOf Bcl-xL,down-regulating
R3747 T5359 T5395 themeOf p53,up-regulating
R3748 T5407 T5406 themeOf phosphorylation,ectopic
R3749 T5409 T5408 themeOf binding,anchored
R3750 T5362 T5397 themeOf WWOX,phosphorylation
R3751 T5363 T5398 themeOf WWOX,binds
R3752 T5364 T5400 themeOf WWOX,induces
R3753 T5364 T5399 themeOf WWOX,translocate
R3754 T5365 T5404 themeOf WWOX,expression
R3755 T5409 T5408 themeOf binding,anchored
R3756 T5366 T5401 themeOf procaspase-3,activation
R3758 T5367 T5401 themeOf procaspase-9,activation
R3759 T5368 T5407 themeOf WWOX,phosphorylation
R3760 T5370 T5409 themeOf Hyal-2,binding
R3761 T5371 T5409 themeOf Ezrin,binding
R3762 T5372 T5410 themeOf Transforming growth factor β1,binds
R3763 T5373 T5410 themeOf Hyal-2,binds
R3764 T5374 T5376 themeOf Expression,altered
R3765 T5374 T5375 themeOf Expression,lost
R3766 T5381 T5379 themeOf relocation,block
R4978 T7107 T7123 themeOf p53,Activated
R4979 T7110 T7124 themeOf BCL-2,inhibiting
R4980 T7114 T7124 causeOf p53,inhibiting
R4981 T7120 T7126 themeOf smooth muscle α-actin,expression
R4982 T7121 T7126 themeOf collagens IIα1,expression
R4983 T7122 T7126 themeOf VIα1,expression
R4984 T7126 T7125 themeOf expression,regulating
R4985 T7126 T7125 themeOf expression,regulating
R4986 T7126 T7125 themeOf expression,regulating
R5478 T7914 T7935 themeOf p53,expression
R5479 T7915 T7936 themeOf p53,localized
R5480 T7916 T7936 themeOf Δ133p53,localized
R5481 T7917 T7936 themeOf p53β,localized
R5482 T7918 T7937 themeOf p53γ,localized
R5483 T7919 T7937 themeOf Δ133p53β,localized
R5484 T7920 T7938 themeOf Δ133p53γ,localized
R5485 T7921 T7939 themeOf p53β,Co-transfection
R5486 T7923 T7940 themeOf p53,co-expression
R5487 T7924 T7940 themeOf Δ133p53,co-expression
R5488 T7926 T7939 themeOf p53,Co-transfection
R5489 T7927 T7942 causeOf Δ133p53,regulates
R5490 T7927 T7941 themeOf Δ133p53,expression
R5491 T7929 T7943 themeOf Δ133p53β,Co-expression
R5492 T7930 T7943 themeOf Δ133p53γ,Co-expression
R5493 T7931 T7943 themeOf p53,Co-expression
R5494 T7941 T7942 themeOf expression,regulates
R6187 T9020 T9045 themeOf p53,Loss
R6188 T9021 T9044 themeOf p53,increases
R6189 T9023 T9046 themeOf WWOX,expression
R6190 T9024 T9048 themeOf WWOX,downregulation
R6191 T9025 T9049 themeOf WWOX,overexpressed
R6192 T9027 T9052 themeOf p53,expressing
R6193 T9028 T9051 themeOf WWOX,ectopic
R6194 T9029 T9053 themeOf WWOX,induces
R6195 T9030 T9054 themeOf caspase-3,independent
R6196 T9033 T9055 themeOf WWOX,Activated
R6197 T9033 T9056 themeOf WWOX,binds
R6198 T9034 T9056 themeOf p53,binds
R6199 T9034 T9057 themeOf p53,phosphorylation
R6200 T9036 T9058 themeOf WWOX,binding
R6201 T9039 T9059 themeOf p53,bind
R6202 T9040 T9059 themeOf WWOX,bind
R6203 T9043 T9060 themeOf p53,expressing
R6204 T9046 T9047 themeOf expression,Altered
R6205 T9052 T9050 themeOf expressing,effect
R7680 T11261 T11304 themeOf WWOX,Binding
R7681 T11262 T11304 themeOf p53,Binding
R7682 T11263 T11305 themeOf WWOX,binds
R7683 T11264 T11306 themeOf WWOX,activated
R7684 T11267 T11307 themeOf p53,interacts
R7685 T11268 T11307 themeOf WWOX,interacts
R7686 T11269 T11309 themeOf p53,binding
R7687 T11270 T11308 themeOf WWOX,interfere
R7688 T11272 T11310 themeOf p53,upregulated
R7689 T11273 T11310 themeOf WWOX,upregulated
R7690 T11274 T11310 themeOf Smad4,upregulated
R7691 T11275 T11310 themeOf PTEN,upregulated
R7692 T11276 T11311 themeOf WWOX,counteracts
R7693 T11280 T11312 themeOf CD44,interacting
R7694 T11281 T11314 themeOf WWOX,expression
R7695 T11282 T11315 themeOf WWOX,loss
R7696 T11283 T11316 themeOf TIAF1,expression
R7697 T11284 T11316 themeOf p53,expression
R7698 T11285 T11316 themeOf WWOX,expression
R7699 T11288 T11318 themeOf WWOX,negative
R7700 T11289 T11319 themeOf WWOX,positive
R7701 T11290 T11317 themeOf WWOX,negative
R7702 T11291 T11320 themeOf WWOX,positive
R7703 T11292 T11323 themeOf WWOX,negative
R7704 T11293 T11321 themeOf WWOX,expressing
R7705 T11294 T11322 themeOf WWOX,expression
R7706 T11295 T11324 themeOf WWOX,negative
R7707 T11296 T11325 themeOf Wwox,knockout
R7708 T11298 T11327 themeOf Wwox,expression
R7709 T11303 T11328 themeOf WWOX,deficiency
R7710 T11309 T11308 causeOf binding,interfere
R7711 T11314 T11313 themeOf expression,lack
R7712 T11327 T11326 themeOf expression,induces
R9325 T13461 T13483 themeOf WWOX,binds
R9326 T13461 T13484 themeOf WWOX,phosphorylated
R9327 T13462 T13483 themeOf p53,binds
R9328 T13463 T13486 themeOf WWOX,binding
R9329 T13463 T13485 themeOf WWOX,binds
R9330 T13463 T13485 themeOf WWOX,binds
R9331 T13463 T13485 themeOf WWOX,binds
R9332 T13464 T13485 themeOf RUNX2,binds
R9333 T13465 T13485 themeOf c-Jun,binds
R9334 T13466 T13485 themeOf ERBB4,binds
R9335 T13467 T13487 themeOf Tau,binds
R9336 T13468 T13487 themeOf WWOX,binds
R9337 T13469 T13488 causeOf WWOX,inhibiting
R9338 T13469 T13490 themeOf WWOX,import
R9339 T13469 T13489 themeOf WWOX,binding
R9340 T13470 T13491 themeOf WWOX,released
R9341 T13470 T13492 themeOf WWOX,translocates
R9342 T13471 T13494 themeOf WWOX,recruited
R9343 T13472 T13493 themeOf Hyal-2,association
R9344 T13473 T13493 themeOf Ezrin,association
R9345 T13473 T13495 themeOf Ezrin,phospho
R9346 T13476 T13496 themeOf TGF-β1,binds
R9347 T13476 T13496 themeOf TGF-β1,binds
R9348 T13477 T13496 themeOf WWOX,binds
R9349 T13477 T13496 themeOf WWOX,binds
R9350 T13478 T13496 themeOf Hyal-2,binds
R9351 T13478 T13496 themeOf Hyal-2,binds
R9352 T13490 T13488 themeOf import,inhibiting
R9931 T14483 T14494 themeOf p53,expressing
R9932 T14484 T14496 themeOf p53,antagonizes
R9933 T14485 T14497 themeOf WWOX,ectopic
R9934 T14485 T14495 themeOf WWOX,binds
R9935 T14486 T14498 themeOf p53,interactions
R9936 T14487 T14498 themeOf WWOX,interactions
R9937 T14488 T14500 themeOf WWOX,ectopic
R9938 T14488 T14501 themeOf WWOX,induce
R9939 T14489 T14499 themeOf p53,expressing
R9940 T14490 T14502 themeOf WWOX,binds
R9941 T14491 T14502 themeOf p53,binds
R9942 T14492 T14503 themeOf WWOX,induction
R9943 T14493 T14504 themeOf p53,expressing
R9944 T14503 T14505 themeOf induction,ectopic

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T355 17-21 Protein denotes WWOX
T356 26-29 Protein denotes p53
T14403 14617-14626 Positive_regulation denotes induction
T14402 14653-14663 Gene_expression denotes expressing
T14401 14559-14564 Binding denotes binds
T14400 14519-14529 Gene_expression denotes expressing
T14399 14392-14404 Binding denotes interactions
T14398 14261-14266 Binding denotes binds
T14397 14284-14295 Binding denotes antagonizes
T14396 14195-14205 Gene_expression denotes expressing
T14395 14664-14667 Protein denotes p53
T14394 14612-14616 Protein denotes WWOX
T14393 14565-14568 Protein denotes p53
T14392 14554-14558 Protein denotes WWOX
T14391 14515-14518 Protein denotes p53
T14390 14483-14487 Protein denotes WWOX
T14389 14437-14441 Protein denotes WWOX
T14388 14420-14423 Protein denotes p53
T14387 14256-14260 Protein denotes WWOX
T14386 14296-14299 Protein denotes p53
T14385 14227-14230 Protein denotes p53
T14384 14151-14155 Protein denotes WWOX
T14383 14104-14107 Protein denotes p53
T14382 14095-14099 Protein denotes WWOX
T14381 14031-14034 Protein denotes p53
T14380 13772-13775 Protein denotes p53
T14379 13728-13732 Protein denotes WWOX
T14378 13720-13723 Protein denotes p53
T13373 8946-8951 Binding denotes binds
T13372 8795-8804 Binding denotes recruited
T13371 8829-8840 Binding denotes association
T13370 8730-8742 Localization denotes translocates
T13369 8716-8724 Localization denotes released
T13368 8581-8588 Binding denotes binding
T13367 8494-8499 Binding denotes binds
T13366 8290-8295 Binding denotes binds
T13365 8154-8168 Phosphorylation denotes phosphorylated
T13364 8182-8187 Binding denotes binds
T13363 9118-9144 Protein denotes hyaluronoglucosaminidase 2
T13362 9110-9116 Protein denotes Hyal-2
T13361 9073-9108 Protein denotes activated Cdc42-associated kinase 1
T13360 9067-9071 Protein denotes Ack1
T13359 8952-8958 Protein denotes Hyal-2
T13358 8941-8945 Protein denotes WWOX
T13357 8933-8939 Protein denotes TGF-β1
T13356 8910-8916 Protein denotes TGF-β1
T13355 8872-8878 Protein denotes Hyal-2
T13354 8865-8870 Protein denotes Ezrin
T13353 8846-8852 Protein denotes Hyal-2
T13352 8787-8791 Protein denotes WWOX
T13351 8725-8729 Protein denotes WWOX
T13350 8524-8528 Protein denotes WWOX
T13349 8489-8493 Protein denotes WWOX
T13348 8500-8503 Protein denotes Tau
T13347 8367-8372 Protein denotes ERBB4
T13346 8356-8361 Protein denotes c-Jun
T13345 8349-8354 Protein denotes RUNX2
T13344 8280-8284 Protein denotes WWOX
T13343 8188-8191 Protein denotes p53
T13342 8146-8150 Protein denotes WWOX
T13341 7575-7579 Protein denotes WWOX
T13340 7533-7537 Protein denotes WWOX
T12522 22781-22785 Protein denotes WWOX
T12521 22773-22776 Protein denotes p53
T11046 22595-22605 Negative_regulation denotes deficiency
T11045 22009-22016 Positive_regulation denotes induces
T11044 21998-22008 Gene_expression denotes expression
T11043 21627-21635 Negative_regulation denotes knockout
T11042 21468-21476 Gene_expression denotes negative
T11041 21407-21417 Gene_expression denotes expression
T11040 21372-21382 Gene_expression denotes expressing
T11039 21305-21313 Gene_expression denotes negative
T11038 21124-21132 Gene_expression denotes negative
T11037 21229-21237 Gene_expression denotes negative
T11036 21173-21181 Gene_expression denotes positive
T11035 21271-21279 Gene_expression denotes positive
T11034 20519-20529 Gene_expression denotes expression
T11033 20388-20392 Negative_regulation denotes loss
T11032 20312-20316 Negative_regulation denotes lack
T11031 20325-20335 Gene_expression denotes expression
T11030 20073-20084 Binding denotes interacting
T11029 19361-19372 Positive_regulation denotes upregulated
T11028 19027-19034 Binding denotes binding
T11027 18845-18854 Binding denotes interacts
T11026 18639-18648 Positive_regulation denotes activated
T11025 17848-17853 Binding denotes binds
T11024 17741-17748 Binding denotes Binding
T11023 22590-22594 Protein denotes WWOX
T11022 22499-22503 Protein denotes WWOX
T11021 22424-22428 Protein denotes WWOX
T11020 22416-22419 Protein denotes p53
T11019 22181-22185 Protein denotes WWOX
T11018 21988-21992 Protein denotes Wwox
T11017 21823-21827 Protein denotes Wwox
T11016 21622-21626 Protein denotes Wwox
T11015 21463-21467 Protein denotes WWOX
T11014 21402-21406 Protein denotes WWOX
T11013 21367-21371 Protein denotes WWOX
T11012 21300-21304 Protein denotes WWOX
T11011 21266-21270 Protein denotes WWOX
T11010 21224-21228 Protein denotes WWOX
T11009 21168-21172 Protein denotes WWOX
T11008 21119-21123 Protein denotes WWOX
T11007 21067-21071 Protein denotes WWOX
T11006 20876-20880 Protein denotes Wwox
T11005 20586-20590 Protein denotes WWOX
T11004 20577-20580 Protein denotes p53
T11003 20533-20538 Protein denotes TIAF1
T11002 20396-20400 Protein denotes WWOX
T11001 20320-20324 Protein denotes WWOX
T11000 20050-20054 Protein denotes CD44
T10999 19903-19907 Protein denotes mTOR
T10998 19898-19901 Protein denotes Akt
T10997 19706-19709 Protein denotes p53
T10996 19657-19661 Protein denotes WWOX
T10995 19321-19325 Protein denotes PTEN
T10994 19314-19319 Protein denotes Smad4
T10993 19308-19312 Protein denotes WWOX
T10992 19303-19306 Protein denotes p53
T10991 19126-19129 Protein denotes p53
T10990 19117-19121 Protein denotes WWOX
T10989 19023-19026 Protein denotes p53
T10988 18860-18864 Protein denotes WWOX
T10987 18828-18831 Protein denotes p53
T10986 18756-18759 Protein denotes p53
T10985 18692-18696 Protein denotes WWOX
T10984 18631-18635 Protein denotes WWOX
T10983 17843-17847 Protein denotes WWOX
T10982 17774-17777 Protein denotes p53
T10981 17762-17766 Protein denotes WWOX
T10980 17685-17689 Protein denotes WWOX
T8918 17597-17607 Gene_expression denotes expressing
T8917 17490-17494 Binding denotes bind
T8916 17211-17218 Binding denotes binding
T8915 17050-17055 Binding denotes binds
T8914 17035-17044 Positive_regulation denotes Activated
T8913 16671-16681 Gene_expression denotes expressing
T8912 16468-16481 Gene_expression denotes overexpressed
T8911 16468-16481 Positive_regulation denotes overexpressed
T8910 16287-16297 Gene_expression denotes expression
T8909 16274-16281 Regulation denotes Altered
T8908 16325-16339 Negative_regulation denotes downregulation
T8907 16153-16162 Positive_regulation denotes increases
T8906 16064-16068 Negative_regulation denotes Loss
T8905 17608-17611 Protein denotes p53
T8904 17568-17572 Protein denotes WWOX
T8903 17526-17530 Protein denotes WWOX
T8902 17503-17507 Protein denotes WWOX
T8901 17470-17473 Protein denotes p53
T8900 17334-17338 Protein denotes WWOX
T8899 17318-17321 Protein denotes p53
T8898 17240-17244 Protein denotes WWOX
T8897 17203-17209 Protein denotes Δ40p53
T8896 17066-17069 Protein denotes p53
T8895 17045-17049 Protein denotes WWOX
T8894 17029-17033 Protein denotes WWOX
T8893 17013-17016 Protein denotes p53
T8892 16784-16793 Protein denotes caspase-3
T8891 16709-16713 Protein denotes WWOX
T8890 16640-16644 Protein denotes WWOX
T8889 16692-16695 Protein denotes p53
T8888 16552-16555 Protein denotes p53
T8887 16482-16486 Protein denotes WWOX
T8886 16343-16347 Protein denotes WWOX
T8885 16282-16286 Protein denotes WWOX
T8884 16205-16208 Protein denotes p53
T8883 16149-16152 Protein denotes p53
T8882 16083-16086 Protein denotes p53
T8881 15852-15855 Protein denotes p53
T7822 15734-15740 Regulation denotes affect
T7821 15678-15691 Gene_expression denotes Co-expression
T7820 15586-15595 Regulation denotes regulates
T7819 15397-15412 Gene_expression denotes Co-transfection
T7818 15471-15484 Gene_expression denotes co-expression
T7817 15346-15355 Localization denotes localized
T7816 15294-15303 Localization denotes localized
T7815 15200-15209 Localization denotes localized
T7814 15077-15087 Gene_expression denotes expression
T7813 15781-15784 Protein denotes Bax
T7812 15773-15776 Protein denotes p21
T7811 15741-15744 Protein denotes p53
T7810 15721-15724 Protein denotes p53
T7809 15707-15715 Protein denotes Δ133p53γ
T7808 15695-15703 Protein denotes Δ133p53β
T7807 15615-15618 Protein denotes p53
T7806 15563-15570 Protein denotes Δ133p53
T7805 15416-15419 Protein denotes p53
T7804 15516-15519 Protein denotes p53
T7803 15497-15504 Protein denotes Δ133p53
T7802 15488-15491 Protein denotes p53
T7801 15439-15442 Protein denotes p53
T7800 15424-15428 Protein denotes p53β
T7799 15334-15342 Protein denotes Δ133p53γ
T7798 15281-15289 Protein denotes Δ133p53β
T7797 15272-15276 Protein denotes p53γ
T7796 15191-15195 Protein denotes p53β
T7795 15178-15185 Protein denotes Δ133p53
T7794 15173-15176 Protein denotes p53
T7793 15091-15094 Protein denotes p53
T7792 14874-14877 Protein denotes p53
T7063 13591-13601 Gene_expression denotes expression
T7062 13576-13586 Regulation denotes regulating
T7061 13283-13293 Negative_regulation denotes inhibiting
T7060 13208-13223 Binding denotes transactivating
T7059 12874-12883 Positive_regulation denotes Activated
T7058 13668-13672 Protein denotes VIα1
T7057 13649-13663 Protein denotes collagens IIα1
T7056 13605-13626 Protein denotes smooth muscle α-actin
T7055 13526-13529 Protein denotes p53
T7054 13348-13351 Protein denotes p53
T7053 13262-13268 Protein denotes SCOTIN
T7052 13256-13260 Protein denotes PUMA
T7051 13251-13254 Protein denotes BAX
T7050 13183-13186 Protein denotes p53
T7049 13176-13181 Protein denotes miR34
T7048 13159-13162 Protein denotes p21
T7047 13062-13065 Protein denotes p53
T7046 13317-13322 Protein denotes BCL-2
T7045 13274-13277 Protein denotes FAS
T7044 13016-13019 Protein denotes p53
T7043 12884-12887 Protein denotes p53
T5133 12668-12673 Binding denotes binds
T5132 12547-12554 Binding denotes binding
T5131 12323-12330 Positive_regulation denotes induces
T5130 12344-12359 Phosphorylation denotes phosphorylation
T5129 12232-12239 Positive_regulation denotes induces
T5128 12179-12186 Positive_regulation denotes induces
T5127 12146-12156 Gene_expression denotes expression
T5126 12217-12227 Positive_regulation denotes activation
T5125 11924-11931 Positive_regulation denotes induces
T5124 11807-11812 Binding denotes binds
T5123 11425-11438 Positive_regulation denotes up-regulating
T5122 11368-11383 Negative_regulation denotes down-regulating
T5121 11096-11109 Gene_expression denotes Overexpressed
T5120 11096-11109 Positive_regulation denotes Overexpressed
T5119 10954-10967 Gene_expression denotes overexpressed
T5118 10973-10983 Binding denotes sequesters
T5117 10954-10967 Positive_regulation denotes overexpressed
T5116 10812-10817 Binding denotes binds
T5115 10674-10683 Binding denotes interacts
T5114 10696-10713 Phosphorylation denotes 46-phosphorylated
T5113 10648-10657 Positive_regulation denotes Activated
T5112 10736-10746 Positive_regulation denotes stabilizes
T5111 10508-10517 Positive_regulation denotes activated
T5110 10552-10557 Binding denotes binds
T5109 10388-10396 Negative_regulation denotes blocking
T5108 10040-10053 Gene_expression denotes overexpressed
T5107 10040-10053 Positive_regulation denotes overexpressed
T5106 10059-10064 Binding denotes binds
T5105 9837-9845 Binding denotes interact
T5104 9638-9649 Negative_regulation denotes Restoration
T5103 9260-9264 Negative_regulation denotes lost
T5102 9249-9256 Regulation denotes altered
T5101 9220-9230 Gene_expression denotes Expression
T5100 12674-12680 Protein denotes Hyal-2
T5099 12638-12667 Protein denotes Transforming growth factor β1
T5098 12612-12617 Protein denotes Ezrin
T5097 12574-12580 Protein denotes Hyal-2
T5096 12492-12496 Protein denotes WWOX
T5095 12339-12343 Protein denotes WWOX
T5094 12204-12216 Protein denotes procaspase-9
T5093 12187-12199 Protein denotes procaspase-3
T5092 12160-12164 Protein denotes WWOX
T5091 11932-11936 Protein denotes WWOX
T5090 11802-11806 Protein denotes WWOX
T5089 11635-11639 Protein denotes WWOX
T5088 11527-11530 Protein denotes p53
T5087 11481-11485 Protein denotes WWOX
T5086 11449-11452 Protein denotes p53
T5085 11414-11420 Protein denotes Bcl-xL
T5084 11404-11409 Protein denotes Bcl-2
T5083 11343-11364 Protein denotes tumor necrosis factor
T5082 11303-11307 Protein denotes WWOX
T5081 11110-11114 Protein denotes WWOX
T5080 11026-11031 Protein denotes Dvl-2
T5079 10984-10989 Protein denotes Dvl-2
T5078 10968-10972 Protein denotes WWOX
T5077 10877-10886 Protein denotes β-catenin
T5076 10807-10811 Protein denotes WWOX
T5075 10747-10750 Protein denotes p53
T5074 10714-10717 Protein denotes p53
T5073 10658-10662 Protein denotes WWOX
T5072 10500-10504 Protein denotes WWOX
T5071 10456-10460 Protein denotes Wwox
T5070 10232-10236 Protein denotes Wwox
T5069 10102-10107 Protein denotes c-Jun
T5068 10093-10096 Protein denotes p73
T5067 10087-10091 Protein denotes AP-2
T5066 10054-10058 Protein denotes WWOX
T5065 9936-9941 Protein denotes RUNX4
T5064 9929-9934 Protein denotes c-Jun
T5063 9921-9927 Protein denotes SIMPLE
T5062 9914-9919 Protein denotes Ezrin
T5061 9907-9912 Protein denotes ErbB4
T5060 9902-9905 Protein denotes p73
T5059 9895-9900 Protein denotes AP-2γ
T5058 9828-9832 Protein denotes WWOX
T5057 9653-9657 Protein denotes WWOX
T5056 9234-9238 Protein denotes WWOX
T5055 7300-7304 Protein denotes WWOX
T5054 7024-7028 Protein denotes WWOX
T5053 6899-6903 Protein denotes Wwox
T5052 6894-6898 Protein denotes WWOX
T5051 6859-6863 Protein denotes WOX1
T5050 6851-6854 Protein denotes FOR
T5049 6845-6849 Protein denotes WWOX
T5048 6799-6834 Protein denotes WW domain-containing oxidoreductase
T5047 6712-6716 Protein denotes WWOX
T5046 6704-6707 Protein denotes p53
T2138 6413-6422 Gene_expression denotes expressed
T2137 6382-6390 Gene_expression denotes positive
T2136 5824-5833 Negative_regulation denotes inhibitor
T2135 5843-5852 Negative_regulation denotes knockdown
T2134 5599-5607 Positive_regulation denotes increase
T2133 4044-4057 Positive_regulation denotes overexpressed
T2132 4044-4057 Gene_expression denotes overexpressed
T2131 4070-4077 Negative_regulation denotes reduces
T2130 3964-3970 Negative_regulation denotes blocks
T2129 3984-3994 Gene_expression denotes expression
T2128 3540-3551 Positive_regulation denotes contributes
T2127 3506-3516 Gene_expression denotes expression
T2126 2514-2524 Negative_regulation denotes inhibition
T2125 6524-6529 Protein denotes CD133
T2124 6376-6381 Protein denotes CD133
T2123 5837-5842 Protein denotes STAT3
T2122 5818-5823 Protein denotes STAT3
T2121 5639-5643 Protein denotes MGMT
T2120 5533-5538 Protein denotes IFN-β
T2119 5519-5531 Protein denotes Interferon-β
T2118 5047-5051 Protein denotes MGMT
T2117 4393-4396 Protein denotes p53
T2116 4177-4188 Protein denotes MicroRNA-21
T2115 4098-4107 Protein denotes caspase-3
T2114 4082-4087 Protein denotes Bcl-2
T2113 4078-4081 Protein denotes Bax
T2112 4058-4069 Protein denotes microRNA-21
T2111 3971-3975 Protein denotes MGMT
T2110 3926-3930 Protein denotes MGMT
T2109 3829-3833 Protein denotes MGMT
T2108 3520-3524 Protein denotes MGMT
T2107 3260-3264 Protein denotes MGMT
T2106 3158-3162 Protein denotes MGMT
T2105 3118-3156 Protein denotes O6-methylguanine-DNA methyltransferase
T2104 2946-2951 Protein denotes MAPO2
T2103 2844-2852 Protein denotes C1orf201
T2102 2837-2842 Protein denotes MAPO2
T2101 2557-2562 Protein denotes Bcl-2
T2100 2542-2547 Protein denotes Bcl-2
T380 934-944 Positive_regulation denotes triggering
T379 950-960 Positive_regulation denotes activation
T378 1003-1013 Negative_regulation denotes deficiency
T377 693-697 Binding denotes bind
T376 702-711 Positive_regulation denotes stabilize
T375 553-563 Gene_expression denotes expression
T374 392-402 Gene_expression denotes expression
T373 374-378 Negative_regulation denotes Loss
T372 988-991 Protein denotes p53
T371 945-949 Protein denotes WWOX
T370 912-916 Protein denotes WWOX
T369 859-862 Protein denotes p53
T368 793-797 Protein denotes WWOX
T367 785-788 Protein denotes p53
T366 722-725 Protein denotes p53
T365 665-669 Protein denotes WWOX
T364 577-581 Protein denotes WWOX
T363 660-663 Protein denotes p53
T362 382-386 Protein denotes WWOX
T361 301-305 Protein denotes WOX1
T360 294-297 Protein denotes FOR
T359 288-292 Protein denotes WWOX
T358 252-287 Protein denotes WW domain-containing oxidoreductase
T357 106-109 Protein denotes p53
R204 T362 T374 themeOf WWOX,expression
R205 T364 T375 themeOf WWOX,expression
R206 T365 T377 themeOf WWOX,bind
R207 T366 T376 themeOf p53,stabilize
R208 T371 T379 themeOf WWOX,activation
R209 T372 T378 themeOf p53,deficiency
R210 T374 T373 themeOf expression,Loss
R211 T379 T380 themeOf activation,triggering
R1476 T2100 T2126 themeOf Bcl-2,inhibition
R1477 T2108 T2127 themeOf MGMT,expression
R1478 T2111 T2129 themeOf MGMT,expression
R1479 T2112 T2132 themeOf microRNA-21,overexpressed
R1480 T2112 T2131 causeOf microRNA-21,reduces
R1481 T2115 T2131 themeOf caspase-3,reduces
R1482 T2119 T2134 themeOf Interferon-β,increase
R1483 T2122 T2136 themeOf STAT3,inhibitor
R1484 T2122 T2135 themeOf STAT3,knockdown
R1485 T2123 T2135 themeOf STAT3,knockdown
R1486 T2124 T2137 themeOf CD133,positive
R1487 T2124 T2138 themeOf CD133,expressed
R1488 T2127 T2128 themeOf expression,contributes
R1490 T2129 T2130 themeOf expression,blocks
R1492 T2132 T2133 themeOf overexpressed,overexpressed
R3591 T5068 T5106 themeOf p73,binds
R3592 T5069 T5106 themeOf c-Jun,binds
R3593 T5071 T5109 themeOf Wwox,blocking
R3594 T5072 T5110 themeOf WWOX,binds
R3595 T5072 T5111 themeOf WWOX,activated
R3596 T5073 T5113 themeOf WWOX,Activated
R3597 T5073 T5115 themeOf WWOX,interacts
R3598 T5074 T5115 themeOf p53,interacts
R3599 T5074 T5114 themeOf p53,46-phosphorylated
R3600 T5075 T5112 themeOf p53,stabilizes
R3601 T5076 T5116 themeOf WWOX,binds
R3602 T5078 T5119 themeOf WWOX,overexpressed
R3603 T5056 T5101 themeOf WWOX,Expression
R3604 T5057 T5104 themeOf WWOX,Restoration
R3605 T5079 T5119 themeOf Dvl-2,overexpressed
R3606 T5058 T5105 themeOf WWOX,interact
R3607 T5079 T5118 themeOf Dvl-2,sequesters
R3608 T5081 T5121 themeOf WWOX,Overexpressed
R3609 T5082 T5122 causeOf WWOX,down-regulating
R3610 T5066 T5108 themeOf WWOX,overexpressed
R3611 T5066 T5106 themeOf WWOX,binds
R3612 T5066 T5106 themeOf WWOX,binds
R3613 T5066 T5106 themeOf WWOX,binds
R3614 T5067 T5106 themeOf AP-2,binds
R3615 T5082 T5122 causeOf WWOX,down-regulating
R3616 T5084 T5122 themeOf Bcl-2,down-regulating
R3617 T5085 T5122 themeOf Bcl-xL,down-regulating
R3618 T5086 T5123 themeOf p53,up-regulating
R3619 T5090 T5124 themeOf WWOX,binds
R3620 T5091 T5125 themeOf WWOX,induces
R3621 T5092 T5127 themeOf WWOX,expression
R3622 T5093 T5126 themeOf procaspase-3,activation
R3623 T5094 T5126 themeOf procaspase-9,activation
R3624 T5095 T5130 themeOf WWOX,phosphorylation
R3625 T5097 T5132 themeOf Hyal-2,binding
R3626 T5099 T5133 themeOf Transforming growth factor β1,binds
R3627 T5100 T5133 themeOf Hyal-2,binds
R3628 T5101 T5102 themeOf Expression,altered
R3629 T5101 T5103 themeOf Expression,lost
R3630 T5108 T5107 themeOf overexpressed,overexpressed
R3631 T5119 T5117 themeOf overexpressed,overexpressed
R3632 T5119 T5117 themeOf overexpressed,overexpressed
R3633 T5121 T5120 themeOf Overexpressed,Overexpressed
R3634 T5126 T5128 themeOf activation,induces
R3635 T5126 T5128 themeOf activation,induces
R3636 T5127 T5129 themeOf expression,induces
R3637 T5130 T5131 themeOf phosphorylation,induces
R4955 T7043 T7059 themeOf p53,Activated
R4958 T7051 T7060 themeOf BAX,transactivating
R4960 T7053 T7060 themeOf SCOTIN,transactivating
R6142 T8887 T8912 themeOf WWOX,overexpressed
R6143 T8889 T8913 themeOf p53,expressing
R6144 T8895 T8914 themeOf WWOX,Activated
R6145 T8895 T8915 themeOf WWOX,binds
R6146 T8896 T8915 themeOf p53,binds
R6147 T8898 T8916 themeOf WWOX,binding
R6148 T8902 T8917 themeOf WWOX,bind
R6149 T8905 T8918 themeOf p53,expressing
R6150 T8910 T8909 themeOf expression,Altered
R6151 T8912 T8911 themeOf overexpressed,overexpressed
R7551 T10981 T11024 themeOf WWOX,Binding
R7552 T10982 T11024 themeOf p53,Binding
R7553 T10983 T11025 themeOf WWOX,binds
R7554 T10984 T11026 themeOf WWOX,activated
R7555 T10987 T11027 themeOf p53,interacts
R7556 T10988 T11027 themeOf WWOX,interacts
R7557 T10989 T11028 themeOf p53,binding
R7558 T10992 T11029 themeOf p53,upregulated
R7559 T10993 T11029 themeOf WWOX,upregulated
R7560 T10994 T11029 themeOf Smad4,upregulated
R7561 T10995 T11029 themeOf PTEN,upregulated
R7562 T11000 T11030 themeOf CD44,interacting
R7563 T11001 T11031 themeOf WWOX,expression
R7564 T11002 T11033 themeOf WWOX,loss
R7565 T11003 T11034 themeOf TIAF1,expression
R7566 T11004 T11034 themeOf p53,expression
R7567 T11005 T11034 themeOf WWOX,expression
R7568 T11008 T11038 themeOf WWOX,negative
R7569 T11009 T11036 themeOf WWOX,positive
R7570 T11010 T11037 themeOf WWOX,negative
R7571 T11011 T11035 themeOf WWOX,positive
R7572 T11012 T11039 themeOf WWOX,negative
R7573 T11013 T11040 themeOf WWOX,expressing
R7574 T11014 T11041 themeOf WWOX,expression
R7575 T11015 T11042 themeOf WWOX,negative
R7576 T11016 T11043 themeOf Wwox,knockout
R7577 T11018 T11044 themeOf Wwox,expression
R7578 T11023 T11046 themeOf WWOX,deficiency
R7579 T11031 T11032 themeOf expression,lack
R7580 T11044 T11045 themeOf expression,induces
R9272 T13342 T13364 themeOf WWOX,binds
R9273 T13342 T13365 themeOf WWOX,phosphorylated
R9274 T13343 T13364 themeOf p53,binds
R9275 T13344 T13366 themeOf WWOX,binds
R9276 T13344 T13366 themeOf WWOX,binds
R9277 T13344 T13366 themeOf WWOX,binds
R9278 T13345 T13366 themeOf RUNX2,binds
R9279 T13346 T13366 themeOf c-Jun,binds
R9280 T13347 T13366 themeOf ERBB4,binds
R9281 T13348 T13367 themeOf Tau,binds
R9282 T13349 T13367 themeOf WWOX,binds
R9283 T13350 T13368 themeOf WWOX,binding
R9284 T13351 T13369 themeOf WWOX,released
R9285 T13351 T13370 themeOf WWOX,translocates
R9286 T13352 T13372 themeOf WWOX,recruited
R9287 T13353 T13371 themeOf Hyal-2,association
R9288 T13354 T13371 themeOf Ezrin,association
R9289 T13358 T13373 themeOf WWOX,binds
R9290 T13359 T13373 themeOf Hyal-2,binds
R9896 T14385 T14396 themeOf p53,expressing
R9897 T14386 T14397 themeOf p53,antagonizes
R9898 T14387 T14398 themeOf WWOX,binds
R9899 T14388 T14399 themeOf p53,interactions
R9900 T14389 T14399 themeOf WWOX,interactions
R9901 T14391 T14400 themeOf p53,expressing
R9902 T14392 T14401 themeOf WWOX,binds
R9903 T14393 T14401 themeOf p53,binds
R9904 T14394 T14403 themeOf WWOX,induction
R9905 T14395 T14402 themeOf p53,expressing
R4956 T7045 T7060 themeOf FAS,transactivating
R4957 T7046 T7061 themeOf BCL-2,inhibiting
R4959 T7052 T7060 themeOf PUMA,transactivating
R4961 T7056 T7063 themeOf smooth muscle α-actin,expression
R4962 T7057 T7063 themeOf collagens IIα1,expression
R4963 T7058 T7063 themeOf VIα1,expression
R4964 T7063 T7062 themeOf expression,regulating
R4965 T7063 T7062 themeOf expression,regulating
R4966 T7063 T7062 themeOf expression,regulating
R5426 T7793 T7814 themeOf p53,expression
R5427 T7794 T7815 themeOf p53,localized
R5428 T7795 T7815 themeOf Δ133p53,localized
R5429 T7796 T7815 themeOf p53β,localized
R5430 T7797 T7816 themeOf p53γ,localized
R5431 T7798 T7816 themeOf Δ133p53β,localized
R5432 T7799 T7817 themeOf Δ133p53γ,localized
R5433 T7800 T7819 themeOf p53β,Co-transfection
R5434 T7802 T7818 themeOf p53,co-expression
R5435 T7803 T7818 themeOf Δ133p53,co-expression
R5436 T7805 T7819 themeOf p53,Co-transfection
R5437 T7806 T7820 themeOf Δ133p53,regulates
R5438 T7808 T7821 themeOf Δ133p53β,Co-expression
R5439 T7809 T7821 themeOf Δ133p53γ,Co-expression
R5440 T7810 T7821 themeOf p53,Co-expression
R5441 T7811 T7822 themeOf p53,affect
R6138 T8882 T8906 themeOf p53,Loss
R6139 T8883 T8907 themeOf p53,increases
R6140 T8885 T8910 themeOf WWOX,expression
R6141 T8886 T8908 themeOf WWOX,downregulation

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T390 26-29 http://www.uniprot.org/uniprot/P04637 denotes p53
T14421 14612-14616 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T14420 14554-14558 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T14419 14483-14487 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T14418 14437-14441 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T14417 14256-14260 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T14416 14151-14155 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T14415 14095-14099 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T14414 13728-13732 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T14413 14664-14667 http://www.uniprot.org/uniprot/P04637 denotes p53
T14412 14565-14568 http://www.uniprot.org/uniprot/P04637 denotes p53
T14411 14515-14518 http://www.uniprot.org/uniprot/P04637 denotes p53
T13389 8553-8562 http://www.uniprot.org/uniprot/P35222 denotes β-catenin
T13388 8356-8361 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T13387 8349-8354 http://www.uniprot.org/uniprot/Q13950 denotes RUNX2
T13386 8202-8205 http://www.uniprot.org/uniprot/P04637 denotes p53
T13385 8188-8191 http://www.uniprot.org/uniprot/P04637 denotes p53
T13384 8941-8945 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T13383 8787-8791 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T13382 8725-8729 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T13381 8677-8681 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T13380 8524-8528 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T13379 8489-8493 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T13378 8280-8284 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T13377 8197-8201 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T13376 8146-8150 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T13375 7575-7579 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T13374 7533-7537 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T12524 22781-22785 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T12523 22773-22776 http://www.uniprot.org/uniprot/P04637 denotes p53
T11087 20540-20545 http://www.uniprot.org/uniprot/P01137 denotes TGF-β
T11086 19903-19907 http://www.uniprot.org/uniprot/P42345 denotes mTOR
T11085 19898-19901 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T11084 19898-19901 http://www.uniprot.org/uniprot/P31751 denotes Akt
T11083 19898-19901 http://www.uniprot.org/uniprot/P31749 denotes Akt
T11082 19314-19319 http://www.uniprot.org/uniprot/Q13485 denotes Smad4
T11081 22398-22419 http://www.uniprot.org/uniprot/P04637 denotes tumor suppressors p53
T11080 20577-20580 http://www.uniprot.org/uniprot/P04637 denotes p53
T11079 19706-19709 http://www.uniprot.org/uniprot/P04637 denotes p53
T11078 19303-19306 http://www.uniprot.org/uniprot/P04637 denotes p53
T11077 19126-19129 http://www.uniprot.org/uniprot/P04637 denotes p53
T11076 19023-19026 http://www.uniprot.org/uniprot/P04637 denotes p53
T11075 18828-18831 http://www.uniprot.org/uniprot/P04637 denotes p53
T11074 18756-18759 http://www.uniprot.org/uniprot/P04637 denotes p53
T11073 17774-17777 http://www.uniprot.org/uniprot/P04637 denotes p53
T11072 22590-22594 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11071 22499-22503 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11070 22424-22428 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11069 22181-22185 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11068 21463-21467 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11067 21402-21406 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11066 21367-21371 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11065 21300-21304 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11064 21266-21270 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11063 21224-21228 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11062 21168-21172 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11061 21119-21123 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11060 21067-21071 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11059 20586-20590 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11058 20396-20400 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11057 20320-20324 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11056 19657-19661 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11055 19308-19312 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11054 19117-19121 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11053 18860-18864 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11052 18692-18696 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11051 18631-18635 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11050 18010-18014 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11049 17843-17847 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11048 17762-17766 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T11047 17685-17689 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8929 17608-17611 http://www.uniprot.org/uniprot/P04637 denotes p53
T8928 17470-17473 http://www.uniprot.org/uniprot/P04637 denotes p53
T8927 17318-17321 http://www.uniprot.org/uniprot/P04637 denotes p53
T8926 17066-17069 http://www.uniprot.org/uniprot/P04637 denotes p53
T8925 17013-17016 http://www.uniprot.org/uniprot/P04637 denotes p53
T8924 16692-16695 http://www.uniprot.org/uniprot/P04637 denotes p53
T8923 16552-16555 http://www.uniprot.org/uniprot/P04637 denotes p53
T8922 16205-16208 http://www.uniprot.org/uniprot/P04637 denotes p53
T8921 16149-16152 http://www.uniprot.org/uniprot/P04637 denotes p53
T8920 16083-16086 http://www.uniprot.org/uniprot/P04637 denotes p53
T8919 15852-15855 http://www.uniprot.org/uniprot/P04637 denotes p53
T7832 15741-15744 http://www.uniprot.org/uniprot/P04637 denotes p53
T7831 15721-15724 http://www.uniprot.org/uniprot/P04637 denotes p53
T7830 15615-15618 http://www.uniprot.org/uniprot/P04637 denotes p53
T7829 15516-15519 http://www.uniprot.org/uniprot/P04637 denotes p53
T7828 15488-15491 http://www.uniprot.org/uniprot/P04637 denotes p53
T7827 15439-15442 http://www.uniprot.org/uniprot/P04637 denotes p53
T7826 15416-15419 http://www.uniprot.org/uniprot/P04637 denotes p53
T7825 15173-15176 http://www.uniprot.org/uniprot/P04637 denotes p53
T7824 15091-15094 http://www.uniprot.org/uniprot/P04637 denotes p53
T7823 14874-14877 http://www.uniprot.org/uniprot/P04637 denotes p53
T7069 13526-13529 http://www.uniprot.org/uniprot/P04637 denotes p53
T7068 13348-13351 http://www.uniprot.org/uniprot/P04637 denotes p53
T7067 13183-13186 http://www.uniprot.org/uniprot/P04637 denotes p53
T7066 13062-13065 http://www.uniprot.org/uniprot/P04637 denotes p53
T7065 13016-13019 http://www.uniprot.org/uniprot/P04637 denotes p53
T7064 12884-12887 http://www.uniprot.org/uniprot/P04637 denotes p53
T5167 11343-11364 http://www.uniprot.org/uniprot/P01375 denotes tumor necrosis factor
T5166 10877-10886 http://www.uniprot.org/uniprot/P35222 denotes β-catenin
T5165 10102-10107 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T5143 7300-7304 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5142 7024-7028 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5141 6894-6898 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5140 6845-6849 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5139 6712-6716 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5138 11527-11530 http://www.uniprot.org/uniprot/P04637 denotes p53
T5137 11449-11452 http://www.uniprot.org/uniprot/P04637 denotes p53
T5136 10747-10750 http://www.uniprot.org/uniprot/P04637 denotes p53
T5135 10714-10717 http://www.uniprot.org/uniprot/P04637 denotes p53
T5134 6704-6707 http://www.uniprot.org/uniprot/P04637 denotes p53
T2157 4393-4396 http://www.uniprot.org/uniprot/P04637 denotes p53
T2156 4098-4107 http://www.uniprot.org/uniprot/P42574 denotes caspase-3
T2155 5639-5643 http://www.uniprot.org/uniprot/P16455 denotes MGMT
T2154 5047-5051 http://www.uniprot.org/uniprot/P16455 denotes MGMT
T2153 3971-3975 http://www.uniprot.org/uniprot/P16455 denotes MGMT
T2152 3926-3930 http://www.uniprot.org/uniprot/P16455 denotes MGMT
T2151 3829-3833 http://www.uniprot.org/uniprot/P16455 denotes MGMT
T2150 3520-3524 http://www.uniprot.org/uniprot/P16455 denotes MGMT
T2149 3260-3264 http://www.uniprot.org/uniprot/P16455 denotes MGMT
T2148 3158-3162 http://www.uniprot.org/uniprot/P16455 denotes MGMT
T2147 3135-3156 http://www.uniprot.org/uniprot/Q9UBC3 denotes DNA methyltransferase
T2146 3135-3156 http://www.uniprot.org/uniprot/Q9UIS9 denotes DNA methyltransferase
T2145 3135-3156 http://www.uniprot.org/uniprot/Q9UBB5 denotes DNA methyltransferase
T2144 3135-3156 http://www.uniprot.org/uniprot/O95243 denotes DNA methyltransferase
T2143 3135-3156 http://www.uniprot.org/uniprot/Q9Y6K1 denotes DNA methyltransferase
T2142 3135-3156 http://www.uniprot.org/uniprot/P26358 denotes DNA methyltransferase
T2141 5837-5842 http://www.uniprot.org/uniprot/P40763 denotes STAT3
T2140 5818-5823 http://www.uniprot.org/uniprot/P40763 denotes STAT3
T2139 2051-2056 http://www.uniprot.org/uniprot/P40763 denotes STAT3
T396 89-109 http://www.uniprot.org/uniprot/P04637 denotes Tumor suppressor p53
T395 859-862 http://www.uniprot.org/uniprot/P04637 denotes p53
T394 785-788 http://www.uniprot.org/uniprot/P04637 denotes p53
T393 722-725 http://www.uniprot.org/uniprot/P04637 denotes p53
T392 660-663 http://www.uniprot.org/uniprot/P04637 denotes p53
T391 106-109 http://www.uniprot.org/uniprot/P04637 denotes p53
T389 301-305 http://www.uniprot.org/uniprot/Q9NZC7 denotes WOX1
T388 294-297 http://www.uniprot.org/uniprot/Q9NZC7 denotes FOR
T387 912-916 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T386 793-797 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T382 288-292 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T383 382-386 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T384 577-581 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T385 665-669 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T381 17-21 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5153 11303-11307 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5152 11110-11114 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5151 10968-10972 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5150 10807-10811 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5149 10658-10662 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5148 10500-10504 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5147 10054-10058 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5146 9828-9832 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5145 9653-9657 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5144 9234-9238 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5164 9929-9934 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T5163 6859-6863 http://www.uniprot.org/uniprot/Q9NZC7 denotes WOX1
T5162 6851-6854 http://www.uniprot.org/uniprot/Q9NZC7 denotes FOR
T5161 12492-12496 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5160 12339-12343 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5159 12160-12164 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5158 11932-11936 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5157 11907-11911 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5156 11802-11806 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5155 11635-11639 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T5154 11481-11485 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8935 17029-17033 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8934 16709-16713 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8933 16640-16644 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8932 16482-16486 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8931 16343-16347 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8930 16282-16286 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T14410 14420-14423 http://www.uniprot.org/uniprot/P04637 denotes p53
T14409 14296-14299 http://www.uniprot.org/uniprot/P04637 denotes p53
T14408 14227-14230 http://www.uniprot.org/uniprot/P04637 denotes p53
T14407 14104-14107 http://www.uniprot.org/uniprot/P04637 denotes p53
T14406 14031-14034 http://www.uniprot.org/uniprot/P04637 denotes p53
T14405 13772-13775 http://www.uniprot.org/uniprot/P04637 denotes p53
T14404 13720-13723 http://www.uniprot.org/uniprot/P04637 denotes p53
T8942 16784-16793 http://www.uniprot.org/uniprot/P42574 denotes caspase-3
T8941 17568-17572 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8940 17526-17530 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8939 17503-17507 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8938 17334-17338 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8937 17240-17244 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX
T8936 17045-17049 http://www.uniprot.org/uniprot/Q9NZC7 denotes WWOX

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T4023 12674-12680 Protein denotes Hyal-2
T14127 14664-14667 Protein denotes p53
T14126 14612-14616 Protein denotes WWOX
T12908 9118-9144 Protein denotes hyaluronoglucosaminidase 2
T12907 9110-9116 Protein denotes Hyal-2
T12906 9073-9108 Protein denotes activated Cdc42-associated kinase 1
T12905 9067-9071 Protein denotes Ack1
T12904 8952-8958 Protein denotes Hyal-2
T12903 8941-8945 Protein denotes WWOX
T12902 8933-8939 Protein denotes TGF-β1
T12901 8910-8916 Protein denotes TGF-β1
T12900 8872-8878 Protein denotes Hyal-2
T12899 8865-8870 Protein denotes Ezrin
T12898 8846-8852 Protein denotes Hyal-2
T12897 8787-8791 Protein denotes WWOX
T12896 8725-8729 Protein denotes WWOX
T12895 8524-8528 Protein denotes WWOX
T12894 8500-8503 Protein denotes Tau
T12893 8489-8493 Protein denotes WWOX
T12892 8367-8372 Protein denotes ERBB4
T12891 8356-8361 Protein denotes c-Jun
T12890 8349-8354 Protein denotes RUNX2
T12889 8280-8284 Protein denotes WWOX
T12888 8188-8191 Protein denotes p53
T12887 8146-8150 Protein denotes WWOX
T12886 7575-7579 Protein denotes WWOX
T12885 7533-7537 Protein denotes WWOX
T12469 22781-22785 Protein denotes WWOX
T12468 22773-22776 Protein denotes p53
T9895 21988-21992 Protein denotes Wwox
T9894 21823-21827 Protein denotes Wwox
T9893 21622-21626 Protein denotes Wwox
T9892 21463-21467 Protein denotes WWOX
T9891 21402-21406 Protein denotes WWOX
T9890 21367-21371 Protein denotes WWOX
T9889 21300-21304 Protein denotes WWOX
T9888 21266-21270 Protein denotes WWOX
T9887 21224-21228 Protein denotes WWOX
T9886 21168-21172 Protein denotes WWOX
T9885 21119-21123 Protein denotes WWOX
T9884 21067-21071 Protein denotes WWOX
T9883 20876-20880 Protein denotes Wwox
T9882 20586-20590 Protein denotes WWOX
T9881 20577-20580 Protein denotes p53
T9880 20533-20538 Protein denotes TIAF1
T9879 20396-20400 Protein denotes WWOX
T9878 20320-20324 Protein denotes WWOX
T9877 20050-20054 Protein denotes CD44
T9876 19903-19907 Protein denotes mTOR
T9875 19898-19901 Protein denotes Akt
T9874 19706-19709 Protein denotes p53
T9873 19657-19661 Protein denotes WWOX
T9872 19321-19325 Protein denotes PTEN
T9871 19314-19319 Protein denotes Smad4
T9870 19308-19312 Protein denotes WWOX
T9869 19303-19306 Protein denotes p53
T9868 19126-19129 Protein denotes p53
T9867 19117-19121 Protein denotes WWOX
T9866 19023-19026 Protein denotes p53
T9865 18860-18864 Protein denotes WWOX
T9864 18828-18831 Protein denotes p53
T9863 18756-18759 Protein denotes p53
T9862 18692-18696 Protein denotes WWOX
T9861 18631-18635 Protein denotes WWOX
T9860 17843-17847 Protein denotes WWOX
T9859 17774-17777 Protein denotes p53
T9858 17762-17766 Protein denotes WWOX
T9857 17685-17689 Protein denotes WWOX
T9900 22590-22594 Protein denotes WWOX
T9899 22499-22503 Protein denotes WWOX
T9898 22424-22428 Protein denotes WWOX
T9897 22416-22419 Protein denotes p53
T9896 22181-22185 Protein denotes WWOX
T8489 17608-17611 Protein denotes p53
T8488 17568-17572 Protein denotes WWOX
T8487 17526-17530 Protein denotes WWOX
T8486 17503-17507 Protein denotes WWOX
T8485 17470-17473 Protein denotes p53
T8484 17334-17338 Protein denotes WWOX
T8483 17318-17321 Protein denotes p53
T8482 17240-17244 Protein denotes WWOX
T8481 17203-17209 Protein denotes Δ40p53
T8480 17066-17069 Protein denotes p53
T8479 17045-17049 Protein denotes WWOX
T8478 17029-17033 Protein denotes WWOX
T8477 17013-17016 Protein denotes p53
T8476 16784-16793 Protein denotes caspase-3
T8475 16709-16713 Protein denotes WWOX
T8474 16692-16695 Protein denotes p53
T8473 16640-16644 Protein denotes WWOX
T8472 16552-16555 Protein denotes p53
T8471 16482-16486 Protein denotes WWOX
T8470 16343-16347 Protein denotes WWOX
T8469 16282-16286 Protein denotes WWOX
T8468 16205-16208 Protein denotes p53
T8467 16149-16152 Protein denotes p53
T8466 16083-16086 Protein denotes p53
T8465 15852-15855 Protein denotes p53
T7561 15424-15428 Protein denotes p53β
T7560 15416-15419 Protein denotes p53
T7559 15334-15342 Protein denotes Δ133p53γ
T7558 15281-15289 Protein denotes Δ133p53β
T7557 15272-15276 Protein denotes p53γ
T7556 15191-15195 Protein denotes p53β
T7555 15178-15185 Protein denotes Δ133p53
T7554 15173-15176 Protein denotes p53
T7553 15091-15094 Protein denotes p53
T7552 14874-14877 Protein denotes p53
T6821 13668-13672 Protein denotes VIα1
T6820 13649-13663 Protein denotes collagens IIα1
T6819 13605-13626 Protein denotes smooth muscle α-actin
T6818 13526-13529 Protein denotes p53
T6817 13348-13351 Protein denotes p53
T6816 13317-13322 Protein denotes BCL-2
T6815 13274-13277 Protein denotes FAS
T6814 13262-13268 Protein denotes SCOTIN
T6813 13256-13260 Protein denotes PUMA
T6812 13251-13254 Protein denotes BAX
T6811 13183-13186 Protein denotes p53
T6810 13176-13181 Protein denotes miR34
T6809 13159-13162 Protein denotes p21
T6808 13062-13065 Protein denotes p53
T6807 13016-13019 Protein denotes p53
T6806 12884-12887 Protein denotes p53
T4022 12638-12667 Protein denotes Transforming growth factor β1
T4021 12612-12617 Protein denotes Ezrin
T4020 12574-12580 Protein denotes Hyal-2
T4019 12492-12496 Protein denotes WWOX
T4018 12339-12343 Protein denotes WWOX
T4017 12204-12216 Protein denotes procaspase-9
T4016 12187-12199 Protein denotes procaspase-3
T4015 12160-12164 Protein denotes WWOX
T4014 11932-11936 Protein denotes WWOX
T4013 11802-11806 Protein denotes WWOX
T4012 11635-11639 Protein denotes WWOX
T4011 11527-11530 Protein denotes p53
T4010 11481-11485 Protein denotes WWOX
T4009 11449-11452 Protein denotes p53
T4008 11414-11420 Protein denotes Bcl-xL
T4007 11404-11409 Protein denotes Bcl-2
T4006 11343-11364 Protein denotes tumor necrosis factor
T4005 11303-11307 Protein denotes WWOX
T4004 11110-11114 Protein denotes WWOX
T4003 11026-11031 Protein denotes Dvl-2
T4002 10984-10989 Protein denotes Dvl-2
T4001 10968-10972 Protein denotes WWOX
T4000 10877-10886 Protein denotes β-catenin
T3999 10807-10811 Protein denotes WWOX
T3998 10747-10750 Protein denotes p53
T3997 10714-10717 Protein denotes p53
T3996 10658-10662 Protein denotes WWOX
T3995 10500-10504 Protein denotes WWOX
T3984 9907-9912 Protein denotes ErbB4
T3983 9902-9905 Protein denotes p73
T3982 9895-9900 Protein denotes AP-2γ
T3981 9828-9832 Protein denotes WWOX
T3980 9653-9657 Protein denotes WWOX
T3979 9234-9238 Protein denotes WWOX
T3978 7300-7304 Protein denotes WWOX
T3977 7024-7028 Protein denotes WWOX
T3976 6899-6903 Protein denotes Wwox
T3975 6894-6898 Protein denotes WWOX
T3974 6859-6863 Protein denotes WOX1
T3973 6851-6854 Protein denotes FOR
T3972 6845-6849 Protein denotes WWOX
T3971 6799-6834 Protein denotes WW domain-containing oxidoreductase
T3970 6712-6716 Protein denotes WWOX
T3969 6704-6707 Protein denotes p53
T1966 6524-6529 Protein denotes CD133
T1965 6376-6381 Protein denotes CD133
T1964 5837-5842 Protein denotes STAT3
T1963 5818-5823 Protein denotes STAT3
T1962 5639-5643 Protein denotes MGMT
T1961 5533-5538 Protein denotes IFN-β
T1960 5519-5531 Protein denotes Interferon-β
T1959 5047-5051 Protein denotes MGMT
T1958 4393-4396 Protein denotes p53
T1957 4177-4188 Protein denotes MicroRNA-21
T1956 4098-4107 Protein denotes caspase-3
T1955 4082-4087 Protein denotes Bcl-2
T1954 4078-4081 Protein denotes Bax
T1953 4058-4069 Protein denotes microRNA-21
T1952 3971-3975 Protein denotes MGMT
T1951 3926-3930 Protein denotes MGMT
T1950 3829-3833 Protein denotes MGMT
T1949 3520-3524 Protein denotes MGMT
T1948 3260-3264 Protein denotes MGMT
T1947 3158-3162 Protein denotes MGMT
T1946 3118-3156 Protein denotes O6-methylguanine-DNA methyltransferase
T1945 2946-2951 Protein denotes MAPO2
T1944 2844-2852 Protein denotes C1orf201
T1943 2837-2842 Protein denotes MAPO2
T1942 2557-2562 Protein denotes Bcl-2
T1941 2542-2547 Protein denotes Bcl-2
T118 17-21 Protein denotes WWOX
T119 26-29 Protein denotes p53
T120 106-109 Protein denotes p53
T121 252-287 Protein denotes WW domain-containing oxidoreductase
T122 288-292 Protein denotes WWOX
T123 294-297 Protein denotes FOR
T124 301-305 Protein denotes WOX1
T125 382-386 Protein denotes WWOX
T126 577-581 Protein denotes WWOX
T127 660-663 Protein denotes p53
T128 665-669 Protein denotes WWOX
T129 722-725 Protein denotes p53
T130 785-788 Protein denotes p53
T131 793-797 Protein denotes WWOX
T132 859-862 Protein denotes p53
T133 912-916 Protein denotes WWOX
T134 945-949 Protein denotes WWOX
T135 988-991 Protein denotes p53
T3994 10456-10460 Protein denotes Wwox
T3993 10232-10236 Protein denotes Wwox
T3992 10102-10107 Protein denotes c-Jun
T3991 10093-10096 Protein denotes p73
T3990 10087-10091 Protein denotes AP-2
T3989 10054-10058 Protein denotes WWOX
T3988 9936-9941 Protein denotes RUNX4
T3987 9929-9934 Protein denotes c-Jun
T3986 9921-9927 Protein denotes SIMPLE
T3985 9914-9919 Protein denotes Ezrin
T14125 14565-14568 Protein denotes p53
T14124 14554-14558 Protein denotes WWOX
T14123 14515-14518 Protein denotes p53
T14122 14483-14487 Protein denotes WWOX
T14121 14437-14441 Protein denotes WWOX
T14120 14420-14423 Protein denotes p53
T14119 14296-14299 Protein denotes p53
T14118 14256-14260 Protein denotes WWOX
T14117 14227-14230 Protein denotes p53
T14116 14151-14155 Protein denotes WWOX
T14115 14104-14107 Protein denotes p53
T14114 14095-14099 Protein denotes WWOX
T14113 14031-14034 Protein denotes p53
T14112 13772-13775 Protein denotes p53
T14111 13728-13732 Protein denotes WWOX
T14110 13720-13723 Protein denotes p53
T7573 15781-15784 Protein denotes Bax
T7572 15773-15776 Protein denotes p21
T7571 15741-15744 Protein denotes p53
T7570 15721-15724 Protein denotes p53
T7569 15707-15715 Protein denotes Δ133p53γ
T7568 15695-15703 Protein denotes Δ133p53β
T7567 15615-15618 Protein denotes p53
T7566 15563-15570 Protein denotes Δ133p53
T7565 15516-15519 Protein denotes p53
T7564 15497-15504 Protein denotes Δ133p53
T7563 15488-15491 Protein denotes p53
T7562 15439-15442 Protein denotes p53

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T12884 8466-8470 Anaphor denotes them
T12883 8367-8372 Antecedent denotes ERBB4
T12882 8356-8361 Antecedent denotes c-Jun
T12881 8349-8354 Antecedent denotes RUNX2
T12880 8438-8452 Anaphor denotes these proteins
T12879 8290-8295 Antecedent denotes binds
T12878 8403-8414 Anaphor denotes the binding
T3968 10674-10683 Antecedent denotes interacts
T3967 10730-10735 Anaphor denotes which
T3966 10102-10107 Antecedent denotes c-Jun
T3965 10093-10096 Antecedent denotes p73
T3964 10087-10091 Antecedent denotes AP-2
T3963 10118-10123 Anaphor denotes their
T1940 3945-3956 Antecedent denotes methylation
T1939 3958-3963 Anaphor denotes which
T7551 15191-15195 Antecedent denotes p53β
T7550 15178-15185 Antecedent denotes Δ133p53
T7549 15173-15176 Antecedent denotes p53
T7548 15249-15253 Anaphor denotes them
T8464 17203-17209 Antecedent denotes Δ40p53
T8463 17222-17234 Anaphor denotes this protein
T8462 17050-17055 Antecedent denotes binds
T8461 17144-17168 Anaphor denotes the binding interactions
T9856 20050-20054 Antecedent denotes CD44
T9855 20058-20068 Anaphor denotes a receptor
R5810 T8461 T8462 boundBy the binding interactions,binds
R5811 T8463 T8464 boundBy this protein,Δ40p53
R5247 T7548 T7549 boundBy them,p53
R5248 T7548 T7550 boundBy them,Δ133p53
R5249 T7548 T7551 boundBy them,p53β
R6628 T9855 T9856 boundBy a receptor,CD44
R1455 T1939 T1940 boundBy which,methylation
R2744 T3963 T3964 boundBy their,AP-2
R2745 T3963 T3965 boundBy their,p73
R2746 T3963 T3966 boundBy their,c-Jun
R2747 T3967 T3968 boundBy which,interacts
R8920 T12878 T12879 boundBy the binding,binds
R8921 T12880 T12881 boundBy these proteins,RUNX2
R8922 T12880 T12882 boundBy these proteins,c-Jun
R8923 T12880 T12883 boundBy these proteins,ERBB4
R8924 T12884 T12881 boundBy them,RUNX2
R8925 T12884 T12882 boundBy them,c-Jun
R8926 T12884 T12883 boundBy them,ERBB4

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T166 0-5 NN denotes Tumor
T167 6-16 NN denotes Suppressor
T168 17-21 NN denotes WWOX
T169 22-25 CC denotes and
T170 26-29 NN denotes p53
T171 30-41 NN denotes Alterations
T172 42-45 CC denotes and
T173 46-50 NNP denotes Drug
T174 51-61 NNP denotes Resistance
T175 62-64 IN denotes in
T176 65-78 NN denotes Glioblastomas
T1086 2074-2080 NN denotes others
T8855 17650-17661 VB denotes established
T13130 7971-7976 NN denotes sites
T14359 14826-14832 NN denotes region
T14358 14820-14825 JJ denotes basic
T14357 14818-14819 -COMMA- denotes ,
T14356 14816-14818 NN denotes BR
T14355 14814-14815 -COLON- denotes ;
T14354 14808-14814 NN denotes domain
T14353 14792-14807 NN denotes oligomerization
T14352 14790-14791 -COMMA- denotes ,
T14351 14788-14790 NN denotes OD
T14350 14786-14787 -COLON- denotes ;
T14349 14780-14786 NN denotes signal
T14348 14767-14779 NN denotes localization
T14347 14759-14766 JJ denotes nuclear
T14346 14757-14758 -COMMA- denotes ,
T14345 14754-14757 NN denotes NLS
T14344 14752-14753 -COLON- denotes ;
T14343 14746-14752 NN denotes domain
T14342 14738-14745 NN denotes proline
T14341 14736-14737 -COMMA- denotes ,
T14340 14733-14736 NN denotes PrD
T14339 14731-14732 -COLON- denotes ;
T14338 14725-14731 NN denotes domain
T14337 14709-14724 NN denotes transactivation
T14336 14707-14708 -COMMA- denotes ,
T14335 14704-14707 NN denotes TAD
T14334 14691-14702 VB denotes established
T14333 14688-14690 VB denotes be
T14332 14685-14687 TO denotes to
T14331 14677-14684 VB denotes remains
T14330 14668-14676 NN denotes isoforms
T14329 14664-14667 NN denotes p53
T14328 14653-14663 VB denotes expressing
T14327 14647-14652 NN denotes cells
T14326 14643-14646 NN denotes GBM
T14325 14640-14642 IN denotes in
T14319 14596-14603 IN denotes whether
T14318 14594-14595 -COMMA- denotes ,
T14317 14590-14594 RB denotes Also
T14316 14581-14588 JJ denotes unknown
T14315 14578-14580 VB denotes is
T14314 14569-14577 NN denotes isoforms
T14313 14565-14568 NN denotes p53
T14312 14559-14564 VB denotes binds
T14311 14554-14558 NN denotes WWOX
T14310 14546-14553 IN denotes whether
T14309 14544-14545 -COMMA- denotes ,
T14308 14537-14544 RB denotes Finally
T14307 14530-14535 NN denotes cells
T14306 14515-14529 JJ denotes p53-expressing
T14305 14508-14514 JJ denotes mutant
T14304 14505-14507 IN denotes in
T14303 14495-14504 NN denotes apoptosis
T14302 14488-14494 VB denotes induce
T14301 14483-14487 NN denotes WWOX
T14300 14475-14482 JJ denotes ectopic
T14299 14473-14474 -COMMA- denotes ,
T14298 14469-14473 RB denotes Thus
T14297 14462-14467 NN denotes cells
T14296 14458-14461 NN denotes GBM
T14295 14455-14457 IN denotes in
T14294 14446-14454 VB denotes expected
T14293 14442-14445 VB denotes are
T14292 14437-14441 NN denotes WWOX
T14291 14433-14436 CC denotes and
T14290 14424-14432 NN denotes proteins
T14289 14420-14423 NN denotes p53
T14288 14413-14419 JJ denotes mutant
T14287 14405-14412 IN denotes between
T14286 14392-14404 NN denotes interactions
T14285 14383-14391 JJ denotes physical
T14284 14380-14382 DT denotes no
T14283 14378-14379 -COMMA- denotes ,
T14282 14372-14378 RB denotes Second
T14281 14361-14370 NN denotes apoptosis
T14280 14352-14360 VB denotes inducing
T14279 14349-14351 IN denotes in
T14278 14340-14348 VB denotes function
T14277 14332-14339 NN denotes other’s
T14276 14327-14331 DT denotes each
T14275 14319-14326 VB denotes nullify
T14274 14310-14318 NN denotes proteins
T14273 14305-14309 DT denotes both
T14272 14301-14304 CC denotes and
T14271 14299-14300 -COMMA- denotes ,
T14270 14296-14299 NN denotes p53
T14269 14284-14295 VB denotes antagonizes
T14268 14271-14283 RB denotes functionally
T14267 14267-14270 CC denotes and
T14266 14261-14266 VB denotes binds
T14265 14256-14260 NN denotes WWOX
T14264 14248-14255 JJ denotes ectopic
T14263 14243-14247 IN denotes that
T14262 14235-14242 VB denotes appears
T14261 14232-14234 PRP denotes It
T14260 14227-14230 NN denotes p53
T14259 14222-14226 NN denotes type
T14258 14217-14221 JJ denotes wild
T14257 14206-14216 JJ denotes endogenous
T14256 14195-14205 VB denotes expressing
T14255 14189-14194 NN denotes cells
T14254 14185-14188 NN denotes GBM
T14253 14182-14184 IN denotes of
T14252 14172-14181 NN denotes apoptosis
T14251 14165-14171 VB denotes induce
T14250 14162-14164 TO denotes to
T14249 14156-14161 VB denotes fails
T14248 14151-14155 NN denotes WWOX
T14247 14143-14150 JJ denotes ectopic
T14246 14141-14142 -COMMA- denotes ,
T14245 14136-14141 RB denotes First
T14244 14129-14134 NN denotes death
T14243 14124-14128 NN denotes cell
T14242 14120-14123 NN denotes GBM
T14241 14111-14119 VB denotes regulate
T14240 14108-14110 TO denotes to
T14239 14104-14107 NN denotes p53
T14238 14100-14103 CC denotes and
T14237 14095-14099 NN denotes WWOX
T14236 14091-14094 IN denotes for
T14235 14082-14090 VB denotes proposed
T14234 14078-14081 VB denotes are
T14233 14068-14077 NN denotes scenarios
T14232 14061-14067 JJ denotes likely
T14231 14055-14060 CD denotes Three
T14230 14053-14054 -RRB- denotes )
T14229 14052-14053 NN denotes B
T14228 14051-14052 -LRB- denotes (
T14227 14044-14050 NN denotes shown.
T14226 14039-14043 RB denotes also
T14225 14035-14038 VB denotes are
T14224 14031-14034 NN denotes p53
T14223 14028-14030 IN denotes of
T14222 14020-14027 NN denotes mutants
T14221 14011-14019 NN denotes deletion
T14220 14000-14010 JJ denotes N-terminal
T14219 13992-13998 NN denotes region
T14218 13986-13991 JJ denotes basic
T14217 13984-13985 DT denotes a
T14216 13980-13983 CC denotes and
T14215 13978-13979 -COMMA- denotes ,
T14214 13972-13978 NN denotes domain
T14213 13956-13971 NN denotes oligomerization
T14212 13953-13955 DT denotes an
T14211 13951-13952 -COMMA- denotes ,
T14210 13945-13951 NN denotes signal
T14209 13932-13944 NN denotes localization
T14208 13924-13931 JJ denotes nuclear
T14207 13922-13923 DT denotes a
T14206 13911-13921 VB denotes containing
T14205 13909-13910 -COMMA- denotes ,
T14204 13903-13909 NN denotes domain
T14203 13892-13902 JJ denotes C-terminal
T14202 13890-13891 DT denotes a
T14201 13886-13889 CC denotes and
T14200 13884-13885 -COMMA- denotes ,
T14199 13878-13884 NN denotes region
T14198 13866-13877 JJ denotes DNA-binding
T14197 13858-13865 JJ denotes central
T14196 13856-13857 DT denotes a
T14195 13854-13855 -COMMA- denotes ,
T14194 13848-13854 NN denotes domain
T14193 13835-13847 JJ denotes proline-rich
T14192 13833-13834 DT denotes a
T14191 13831-13832 -COMMA- denotes ,
T14190 13824-13831 NN denotes domains
T14189 13817-13823 JJ denotes acidic
T14188 13801-13816 NN denotes transactivation
T14187 13790-13800 JJ denotes N-terminal
T14186 13786-13789 CD denotes two
T14185 13776-13785 VB denotes possesses
T14184 13772-13775 NN denotes p53
T14183 13760-13771 JJ denotes Full-length
T14182 13758-13759 -RRB- denotes )
T14181 13757-13758 NN denotes A
T14180 13756-13757 -LRB- denotes (
T14179 13745-13755 NN denotes apoptosis.
T14178 13740-13744 NN denotes cell
T14177 13736-13739 NN denotes GBM
T14176 13733-13735 IN denotes in
T14175 13728-13732 NN denotes WWOX
T14174 13724-13727 CC denotes and
T14173 13720-13723 NN denotes p53
T14324 14630-14639 NN denotes apoptosis
T14323 14627-14629 IN denotes of
T14322 14617-14626 NN denotes induction
T14321 14612-14616 NN denotes WWOX
T14320 14604-14611 JJ denotes ectopic
T13339 9217-9218 NN denotes A
T13338 9210-9216 NN denotes kinase
T13337 9202-9209 NN denotes protein
T13336 9200-9201 -COMMA- denotes ,
T13335 9197-9200 NN denotes PKA
T13334 9195-9196 -COLON- denotes ;
T13333 9189-9195 NN denotes kinase
T13332 9180-9188 NN denotes synthase
T13331 9171-9179 NN denotes glycogen
T13330 9169-9170 -COMMA- denotes ,
T13329 9166-9169 NN denotes GSK
T13328 9164-9165 -COLON- denotes ;
T13327 9158-9164 NN denotes kinase
T13326 9151-9157 NN denotes casein
T13325 9149-9150 -COMMA- denotes ,
T13324 9146-9149 NN denotes CKI
T13323 9144-9145 -COLON- denotes ;
T13322 9143-9144 CD denotes 2
T13321 9118-9142 NN denotes hyaluronoglucosaminidase
T13320 9116-9117 -COMMA- denotes ,
T13319 9110-9116 NN denotes Hyal-2
T13318 9108-9109 -COLON- denotes ;
T13317 9107-9108 CD denotes 1
T13316 9100-9106 NN denotes kinase
T13315 9083-9099 JJ denotes Cdc42-associated
T13314 9073-9082 VB denotes activated
T13313 9071-9072 -COMMA- denotes ,
T13312 9067-9071 NN denotes Ack1
T13311 9057-9065 NN denotes activity
T13310 9048-9056 NN denotes promoter
T13309 9036-9047 JJ denotes SMAD-driven
T13308 9032-9035 DT denotes the
T13307 9022-9031 VB denotes enhancing
T13306 9018-9021 CC denotes and
T13305 9010-9017 NN denotes nucleus
T13304 9006-9009 DT denotes the
T13303 9003-9005 TO denotes to
T13302 8992-9002 VB denotes relocating
T13301 8989-8991 IN denotes by
T13300 8980-8988 VB denotes followed
T13299 8978-8979 -COMMA- denotes ,
T13298 8971-8978 NN denotes complex
T13297 8969-8970 DT denotes a
T13296 8963-8968 VB denotes forms
T13295 8959-8962 CC denotes and
T13294 8952-8958 NN denotes Hyal-2
T13293 8946-8951 VB denotes binds
T13292 8941-8945 NN denotes WWOX
T13291 8939-8940 -COMMA- denotes ,
T13290 8933-8939 NN denotes TGF-β1
T13289 8930-8932 TO denotes to
T13288 8921-8929 NN denotes response
T13287 8918-8920 IN denotes In
T13286 8910-8916 NN denotes TGF-β1
T13285 8906-8909 IN denotes for
T13284 8897-8905 NN denotes receptor
T13283 8885-8896 JJ denotes alternative
T13282 8882-8884 DT denotes an
T13281 8879-8881 VB denotes is
T13280 8872-8878 NN denotes Hyal-2
T13279 8857-8871 JJ denotes phospho-Ezrin.
T13278 8853-8856 CC denotes and
T13277 8846-8852 NN denotes Hyal-2
T13276 8841-8845 IN denotes with
T13275 8829-8840 NN denotes association
T13274 8826-8828 IN denotes by
T13273 8821-8825 NN denotes area
T13272 8812-8820 NN denotes membrane
T13271 8808-8811 DT denotes the
T13270 8805-8807 TO denotes to
T13269 8795-8804 VB denotes recruited
T13268 8792-8794 VB denotes is
T13267 8787-8791 NN denotes WWOX
T13266 8780-8785 NN denotes death
T13265 8775-8779 NN denotes cell
T13264 8767-8774 VB denotes causing
T13263 8763-8766 IN denotes for
T13262 8750-8762 NN denotes mitochondria
T13261 8746-8749 DT denotes the
T13260 8743-8745 TO denotes to
T13259 8730-8742 VB denotes translocates
T13258 8725-8729 NN denotes WWOX
T13257 8716-8724 VB denotes released
T13256 8712-8715 DT denotes the
T13255 8708-8711 CC denotes and
T13254 8706-8707 -COMMA- denotes ,
T13253 8702-8706 NN denotes cell
T13252 8700-8701 NN denotes T
T13251 8693-8699 NN denotes Jurkat
T13250 8690-8692 IN denotes in
T13249 8682-8689 NN denotes complex
T13248 8673-8681 NN denotes MEK/WWOX
T13247 8670-8672 IN denotes of
T13246 8657-8669 NN denotes dissociation
T13245 8653-8656 DT denotes the
T13244 8642-8652 VB denotes stimulates
T13243 8636-8641 NN denotes ester
T13242 8628-8635 NN denotes Phorbol
T13241 8620-8626 NN denotes import
T13240 8612-8619 JJ denotes nuclear
T13239 8608-8611 PRP-DOLLAR- denotes its
T13238 8597-8607 VB denotes inhibiting
T13237 8593-8596 CC denotes and
T13183 8285-8289 RB denotes also
T13182 8280-8284 NN denotes WWOX
T13181 8269-8278 NN denotes apoptosis
T13180 8262-8268 VB denotes induce
T13179 8259-8261 TO denotes to
T13178 8251-8258 NN denotes nucleus
T13177 8248-8250 CC denotes or
T13176 8235-8247 NN denotes mitochondria
T13175 8232-8234 TO denotes to
T13174 8219-8231 VB denotes translocates
T13173 8214-8218 RB denotes then
T13172 8206-8213 NN denotes complex
T13171 8197-8205 NN denotes WWOX/p53
T13170 8193-8196 DT denotes The
T13169 8188-8191 NN denotes p53
T13168 8182-8187 VB denotes binds
T13167 8178-8181 CC denotes and
T13166 8172-8177 NN denotes Tyr33
T13165 8169-8171 IN denotes in
T13164 8154-8168 VB denotes phosphorylated
T13163 8151-8153 VB denotes is
T13162 8146-8150 NN denotes WWOX
T13161 8144-8145 -COMMA- denotes ,
T13160 8133-8144 NN denotes stimulation
T13159 8126-8132 NN denotes stress
T13158 8121-8125 IN denotes Upon
T13157 8107-8119 RB denotes respectively
T13156 8105-8106 -COMMA- denotes ,
T13155 8099-8105 NN denotes Thr3B3
T13154 8095-8098 CC denotes and
T13153 8093-8094 -COMMA- denotes ,
T13152 8087-8093 NN denotes Tyr293
T13151 8085-8086 -COMMA- denotes ,
T13150 8080-8085 NN denotes Tyr61
T13149 8078-8079 -COMMA- denotes ,
T13148 8073-8078 NN denotes Ser14
T13147 8071-8072 -COMMA- denotes ,
T13146 8066-8071 NN denotes Thr12
T13145 8064-8065 -COMMA- denotes ,
T13144 8060-8064 NN denotes Tyr6
T13143 8056-8059 VB denotes are
T13142 8049-8055 NNP denotes Server
T13141 8045-8048 CD denotes 2.0
T13140 8037-8044 NNP denotes NetPhos
T13139 8034-8036 IN denotes by
T13138 8024-8033 VB denotes predicted
T13137 8018-8023 NN denotes sites
T13136 8002-8017 NN denotes phosphorylation
T13135 7996-8001 JJ denotes Other
T13134 7988-7994 NN denotes Tyr287
T13133 7984-7987 CC denotes and
T13132 7978-7983 NN denotes Tyr33
T13131 7976-7977 -COMMA- denotes ,
T13129 7955-7970 NN denotes phosphorylation
T13128 7946-7954 NN denotes tyrosine
T13127 7936-7945 VB denotes conserved
T13126 7932-7935 CD denotes two
T13125 7928-7931 VB denotes are
T13124 7922-7927 EX denotes There
T13123 7914-7920 NN denotes region
T13122 7893-7913 JJ denotes mitochondria-binding
T13121 7891-7892 DT denotes a
T13120 7881-7890 VB denotes possesses
T13119 7874-7880 NN denotes domain
T13118 7870-7873 NN denotes SDR
T13117 7866-7869 DT denotes The
T13116 7863-7864 -RRB- denotes )
T13115 7856-7863 NN denotes reviews
T13114 7854-7855 -COLON- denotes ;
T13113 7850-7854 CD denotes 2012
T13112 7848-7849 -COMMA- denotes ,
T13111 7845-7848 FW denotes al.
T13110 7842-7844 FW denotes et
T13109 7839-7841 NNP denotes Su
T13108 7837-7838 -COLON- denotes ;
T13107 7833-7837 CD denotes 2012
T13106 7831-7832 -COMMA- denotes ,
T13105 7828-7831 FW denotes al.
T13104 7825-7827 FW denotes et
T13103 7819-7824 NNP denotes Salah
T13102 7817-7818 -COLON- denotes ;
T13101 7813-7817 CD denotes 2011
T13100 7811-7812 -COMMA- denotes ,
T13099 7808-7811 FW denotes al.
T13098 7805-7807 FW denotes et
T13097 7800-7804 NNP denotes Mare
T13096 7796-7799 NNP denotes Del
T13095 7794-7795 -COLON- denotes ;
T13094 7790-7794 CD denotes 2007
T13093 7788-7789 -COMMA- denotes ,
T13092 7784-7788 CD denotes 2003
T13091 7782-7783 -COMMA- denotes ,
T13090 7779-7782 FW denotes al.
T13089 7776-7778 FW denotes et
T13088 7770-7775 NNP denotes Chang
T13087 7769-7770 -LRB- denotes (
T13086 7761-7768 NN denotes domains
T13085 7758-7760 NNP denotes WW
T13084 7754-7757 DT denotes the
T13083 7746-7753 IN denotes between
T13082 7743-7745 IN denotes in
T13081 7740-7742 VB denotes is
T13080 7738-7739 -RRB- denotes )
T13079 7735-7738 NN denotes NLS
T13078 7734-7735 -LRB- denotes (
T13077 7727-7733 NN denotes signal
T13076 7714-7726 NN denotes localization
T13075 7706-7713 JJ denotes nuclear
T13074 7704-7705 DT denotes A
T13073 7696-7702 NN denotes region
T13072 7693-7695 NN denotes D3
T13071 7691-7692 DT denotes a
T13070 7687-7690 CC denotes and
T13069 7685-7686 -COMMA- denotes ,
T13068 7679-7685 NN denotes domain
T13067 7677-7678 -RRB- denotes )
T13066 7674-7677 NN denotes SDR
T13065 7673-7674 -LRB- denotes (
T13064 7649-7672 NN denotes dehydrogenase/reductase
T13063 7641-7648 NN denotes alcohol
T13062 7629-7640 NN denotes short-chain
T13061 7618-7628 JJ denotes C-terminal
T13060 7616-7617 DT denotes a
T13059 7614-7615 -COMMA- denotes ,
T13058 7607-7614 NN denotes domains
T13057 7604-7606 NN denotes WW
T13056 7593-7603 JJ denotes N-terminal
T13055 7589-7592 CD denotes two
T13054 7580-7588 VB denotes contains
T13053 7575-7579 NN denotes WWOX
T13052 7564-7573 NN denotes signaling
T13051 7561-7563 IN denotes in
T13050 7556-7560 NN denotes role
T13049 7552-7555 PRP-DOLLAR- denotes its
T13048 7548-7551 CC denotes and
T13047 7538-7547 NN denotes structure
T13046 7533-7537 NN denotes WWOX
T13045 7530-7532 IN denotes of
T13044 7521-7529 NN denotes diagrams
T13043 7511-7520 JJ denotes Schematic
T13236 8589-8592 NN denotes Dvl
T13235 8581-8588 VB denotes binding
T13234 8578-8580 IN denotes by
T13233 8570-8577 NN denotes pathway
T13232 8563-8569 NN denotes signal
T13231 8549-8562 NN denotes Wnt/β-catenin
T13230 8545-8548 DT denotes the
T13229 8542-8544 IN denotes in
T13228 8529-8541 VB denotes participates
T13227 8524-8528 NN denotes WWOX
T13226 8516-8522 NN denotes domain
T13225 8512-8515 NN denotes SDR
T13224 8508-8511 PRP-DOLLAR- denotes its
T13223 8504-8507 IN denotes via
T13222 8500-8503 NNP denotes Tau
T13221 8494-8499 VB denotes binds
T13220 8489-8493 NN denotes WWOX
T13219 8478-8487 NN denotes cytoplasm
T13218 8474-8477 DT denotes the
T13217 8471-8473 IN denotes in
T13216 8466-8470 PRP denotes them
T13215 8456-8465 VB denotes retaining
T13214 8453-8455 IN denotes by
T13213 8444-8452 NN denotes proteins
T13212 8438-8443 DT denotes these
T13211 8435-8437 IN denotes of
T13210 8426-8434 NN denotes activity
T13209 8422-8425 DT denotes the
T13208 8415-8421 VB denotes blocks
T13207 8407-8414 NN denotes binding
T13206 8403-8406 DT denotes the
T13205 8399-8402 CC denotes and
T13204 8397-8398 -COMMA- denotes ,
T13203 8391-8397 NN denotes domain
T13202 8388-8390 NNP denotes WW
T13200 8378-8381 PRP-DOLLAR- denotes its
T13199 8374-8377 IN denotes via
T13198 8372-8373 -COMMA- denotes ,
T13197 8367-8372 NN denotes ERBB4
T13196 8363-8366 CC denotes and
T13195 8361-8362 -COMMA- denotes ,
T13194 8356-8361 NN denotes c-Jun
T13193 8354-8355 -COMMA- denotes ,
T13192 8349-8354 NN denotes RUNX2
T13191 8346-8348 IN denotes as
T13190 8341-8345 JJ denotes such
T13189 8339-8340 -COMMA- denotes ,
T13188 8332-8339 NN denotes factors
T13187 8318-8331 NN denotes transcription
T13186 8301-8317 JJ denotes motif-containing
T13185 8296-8300 NN denotes PPxY
T13184 8290-8295 VB denotes binds
T12617 23141-23149 NN denotes interest
T12616 23138-23140 IN denotes of
T12615 23129-23137 NN denotes conflict
T12614 23119-23128 JJ denotes potential
T12613 23117-23118 DT denotes a
T12612 23114-23116 IN denotes as
T12611 23104-23113 VB denotes construed
T12610 23101-23103 VB denotes be
T12609 23095-23100 MD denotes could
T12608 23090-23094 WDT denotes that
T12607 23076-23089 NN denotes relationships
T12606 23066-23075 JJ denotes financial
T12605 23063-23065 CC denotes or
T12604 23052-23062 JJ denotes commercial
T12603 23048-23051 DT denotes any
T12602 23045-23047 IN denotes of
T12601 23037-23044 NN denotes absence
T12600 23033-23036 DT denotes the
T12599 23030-23032 IN denotes in
T12598 23020-23029 VB denotes conducted
T12597 23016-23019 VB denotes was
T12596 23007-23015 NN denotes research
T12595 23003-23006 DT denotes the
T12594 22998-23002 IN denotes that
T12593 22990-22997 VB denotes declare
T12592 22982-22989 NN denotes authors
T12591 22978-22981 DT denotes The
T12518 22935-22944 NN denotes coauthors
T12517 22930-22934 IN denotes with
T12516 22920-22929 VB denotes discussed
T12515 22916-22919 CC denotes and
T12514 22914-22915 -COMMA- denotes ,
T12513 22904-22914 NN denotes manuscript
T12512 22900-22903 DT denotes the
T12511 22892-22899 VB denotes revised
T12510 22881-22891 RB denotes thoroughly
T12509 22877-22880 CC denotes and
T12508 22871-22876 VB denotes wrote
T12507 22869-22870 -COMMA- denotes ,
T12506 22864-22869 NN denotes ideas
T12505 22854-22863 VB denotes conceived
T12504 22848-22853 NNP denotes Chang
T12503 22839-22847 NNP denotes Nan-Shan
T12502 22837-22838 -COLON- denotes ;
T12501 22828-22837 NN denotes citations
T12500 22820-22827 VB denotes managed
T12499 22815-22819 NNP denotes Wang
T12498 22807-22814 NNP denotes Wan-Jen
T12497 22805-22806 -COLON- denotes ;
T12496 22799-22805 NN denotes graphs
T12495 22790-22798 VB denotes designed
T12494 22786-22789 CC denotes and
T12493 22781-22785 NN denotes WWOX
T12492 22777-22780 CC denotes and
T12491 22773-22776 NN denotes p53
T12490 22769-22772 IN denotes for
T12489 22760-22768 NN denotes sections
T12488 22753-22759 NN denotes review
T12487 22749-22752 DT denotes the
T12486 22743-22748 VB denotes wrote
T12485 22738-22742 NNP denotes Chou
T12484 22731-22737 NNP denotes Pei-Yi
T12483 22729-22730 -COLON- denotes ;
T12482 22726-22729 NN denotes TMZ
T12481 22721-22725 IN denotes with
T12480 22713-22720 VB denotes dealing
T12479 22704-22712 NN denotes sections
T12478 22700-22703 DT denotes the
T12477 22694-22699 VB denotes wrote
T12476 22690-22693 NNP denotes Sze
T12475 22683-22689 NNP denotes Chun-I
T12474 22679-22682 CC denotes and
T12473 22672-22678 NNP denotes Chiang
T12472 22664-22671 NNP denotes Ming-Fu
T10923 22561-22564 CC denotes and
T10922 22559-22560 -COMMA- denotes ,
T10921 22548-22559 NN denotes alterations
T10920 22538-22547 JJ denotes metabolic
T10919 22534-22537 CC denotes and
T10918 22524-22533 NN denotes migration
T10917 22519-22523 NN denotes cell
T10916 22507-22518 VB denotes controlling
T10915 22504-22506 IN denotes in
T10914 22499-22503 NN denotes WWOX
T10913 22496-22498 IN denotes of
T10912 22491-22495 NN denotes role
T10911 22487-22490 DT denotes the
T10910 22481-22486 VB denotes shown
T10909 22476-22480 VB denotes have
T10908 22473-22475 PRP denotes We
T10907 22466-22471 NN denotes cells
T10906 22462-22465 NN denotes GBM
T10905 22459-22461 IN denotes in
T10904 22447-22458 NN denotes sensitivity
T10903 22443-22446 NN denotes TMZ
T10902 22432-22442 VB denotes regulating
T10901 22429-22431 IN denotes in
T10900 22424-22428 NN denotes WWOX
T10899 22420-22423 CC denotes and
T10898 22416-22419 NN denotes p53
T10897 22404-22415 NN denotes suppressors
T10896 22398-22403 NN denotes tumor
T10895 22395-22397 IN denotes of
T10894 22390-22394 NN denotes role
T10893 22380-22389 JJ denotes potential
T10892 22376-22379 DT denotes the
T10891 22366-22375 VB denotes discussed
T10890 22361-22365 VB denotes have
T10889 22358-22360 PRP denotes we
T10888 22350-22357 NN denotes article
T10887 22338-22349 JJ denotes perspective
T10886 22333-22337 DT denotes this
T10885 22330-22332 IN denotes in
T10884 22328-22329 -COMMA- denotes ,
T10883 22321-22328 NN denotes summary
T10882 22318-22320 IN denotes In
T10881 22308-22316 NN denotes invasion
T10880 22304-22307 CC denotes and
T10879 22297-22303 NN denotes growth
T10878 22292-22296 NN denotes cell
T10877 22285-22291 NN denotes cancer
T10876 22281-22284 DT denotes the
T10875 22276-22280 VB denotes curb
T10874 22273-22275 TO denotes to
T10873 22269-22272 NN denotes ROS
T10872 22266-22268 IN denotes of
T10871 22255-22265 NN denotes generation
T10870 22248-22254 VB denotes exerts
T10869 22244-22247 CC denotes and
T10868 22238-22243 NN denotes cells
T10867 22231-22237 NN denotes cancer
T10866 22228-22230 IN denotes in
T10865 22216-22227 NN denotes consumption
T10864 22208-22215 NN denotes glucose
T10863 22199-22207 VB denotes override
T10862 22196-22198 TO denotes to
T10861 22189-22195 JJ denotes likely
T10860 22186-22188 VB denotes is
T10859 22181-22185 NN denotes WWOX
T10858 22179-22180 -COMMA- denotes ,
T10857 22168-22179 RB denotes Conceivably
T10856 22165-22166 -RRB- denotes )
T10855 22161-22165 CD denotes 2012
T10854 22159-22160 -COMMA- denotes ,
T10853 22156-22159 FW denotes al.
T10852 22153-22155 FW denotes et
T10851 22145-22152 NNP denotes Moncada
T10850 22144-22145 -LRB- denotes (
T10849 22136-22143 NNP denotes Warburg
T10848 22126-22135 JJ denotes so-called
T10847 22122-22125 DT denotes the
T10846 22120-22121 VB denotes –
T10845 22110-22119 NN denotes advantage
T10844 22103-22109 NN denotes growth
T10843 22099-22102 IN denotes for
T10842 22088-22098 NN denotes glycolysis
T10841 22080-22087 VB denotes utilize
T10840 22073-22079 RB denotes overly
T10839 22070-22072 TO denotes to
T10838 22064-22069 VB denotes known
T10837 22060-22063 VB denotes are
T10836 22054-22059 NN denotes cells
T10835 22047-22053 NN denotes Cancer
T10834 22035-22046 FW denotes Drosophila.
T10833 22032-22034 IN denotes in
T10832 22021-22031 NN denotes production
T10831 22017-22020 NN denotes ROS
T10830 22009-22016 VB denotes induces
T10829 21998-22008 NN denotes expression
T10828 21993-21997 NN denotes gene
T10827 21988-21992 NN denotes Wwox
T10826 21977-21987 JJ denotes functional
T10825 21975-21976 -COMMA- denotes ,
T10824 21969-21975 NN denotes stress
T10823 21966-21968 NN denotes UV
T10822 21960-21965 IN denotes Under
T10821 21957-21958 -RRB- denotes )
T10820 21953-21957 CD denotes 2011
T10819 21951-21952 -COMMA- denotes ,
T10818 21948-21951 FW denotes al.
T10817 21945-21947 FW denotes et
T10816 21937-21944 NNP denotes O’Keefe
T10815 21936-21937 -LRB- denotes (
T10814 21932-21935 NN denotes ROS
T10813 21929-21931 IN denotes of
T10812 21918-21928 NN denotes generation
T10811 21914-21917 IN denotes for
T10810 21907-21913 NN denotes stress
T10809 21897-21906 JJ denotes oxidative
T10808 21893-21896 CC denotes and
T10807 21882-21892 NN denotes metabolism
T10806 21874-21881 JJ denotes aerobic
T10805 21864-21873 VB denotes involving
T10804 21855-21863 NN denotes pathways
T10803 21852-21854 IN denotes in
T10802 21840-21851 VB denotes participate
T10801 21837-21839 TO denotes to
T10800 21831-21836 VB denotes shown
T10799 21828-21830 VB denotes is
T10798 21823-21827 NNP denotes Wwox
T10797 21821-21822 -COMMA- denotes ,
T10796 21816-21821 NN denotes model
T10795 21805-21815 FW denotes Drosophila
T10794 21803-21804 DT denotes a
T10793 21800-21802 IN denotes In
T10792 21797-21798 -RRB- denotes )
T10791 21793-21797 CD denotes 2012
T10790 21791-21792 -COMMA- denotes ,
T10789 21788-21791 FW denotes al.
T10788 21785-21787 FW denotes et
T10787 21779-21784 NNP denotes Salah
T10786 21777-21778 -COLON- denotes ;
T10785 21773-21777 CD denotes 2011
T10784 21771-21772 -COMMA- denotes ,
T10783 21768-21771 FW denotes al.
T10782 21765-21767 FW denotes et
T10781 21760-21764 NNP denotes Mare
T10780 21756-21759 NNP denotes Del
T10779 21755-21756 -LRB- denotes (
T10778 21741-21754 NN denotes osteosarcomas
T10777 21738-21740 IN denotes of
T10776 21727-21737 NN denotes generation
T10775 21723-21726 CC denotes and
T10774 21721-21722 -COMMA- denotes ,
T10773 21706-21721 NN denotes steroidogenesis
T10772 21704-21705 -COMMA- denotes ,
T10771 21698-21704 NN denotes ataxia
T10770 21696-21697 -COMMA- denotes ,
T10769 21689-21696 NN denotes defects
T10768 21678-21688 NN denotes metabolism
T10767 21673-21677 NN denotes bone
T10766 21671-21672 -COMMA- denotes ,
T10765 21662-21671 NN denotes lethality
T10764 21652-21661 JJ denotes postnatal
T10763 21642-21651 VB denotes including
T10762 21640-21641 -COMMA- denotes ,
T10761 21636-21640 NN denotes mice
T10760 21627-21635 NN denotes knockout
T10759 21622-21626 NNP denotes Wwox
T10758 21619-21621 IN denotes in
T10757 21613-21618 VB denotes shown
T10756 21608-21612 VB denotes been
T10755 21603-21607 VB denotes have
T10754 21591-21602 NN denotes alterations
T10753 21581-21590 JJ denotes Metabolic
T10752 21578-21579 -RRB- denotes )
T10751 21567-21578 JJ denotes unpublished
T10750 21565-21566 -COMMA- denotes ,
T10749 21562-21565 FW denotes al.
T10748 21559-21561 FW denotes et
T10747 21554-21558 NNP denotes Chou
T10746 21553-21554 -LRB- denotes (
T10745 21546-21552 NN denotes tissue
T10744 21540-21545 NN denotes brain
T10743 21532-21539 JJ denotes distant
T10742 21527-21531 IN denotes into
T10741 21518-21526 NN denotes invasion
T10740 21510-21517 JJ denotes diffuse
T10739 21506-21509 DT denotes the
T10738 21502-21505 IN denotes for
T10737 21494-21501 VB denotes account
T10736 21490-21493 MD denotes may
T10735 21484-21489 NN denotes cells
T10734 21477-21483 NN denotes glioma
T10733 21463-21476 JJ denotes WWOX-negative
T10732 21460-21462 IN denotes of
T10731 21451-21459 NN denotes behavior
T10730 21441-21450 JJ denotes migratory
T10729 21437-21440 DT denotes the
T10728 21435-21436 -COMMA- denotes ,
T10727 21425-21435 RB denotes Apparently
T10726 21418-21423 NN denotes areas
T10725 21407-21417 NN denotes expression
T10724 21402-21406 NN denotes WWOX
T10723 21398-21401 JJ denotes low
T10722 21395-21397 TO denotes to
T10721 21389-21394 NN denotes cells
T10720 21383-21388 NN denotes brain
T10719 21367-21382 JJ denotes WWOX-expressing
T10718 21362-21366 IN denotes from
T10717 21357-21361 RP denotes away
T10716 21352-21356 VB denotes turn
T10715 21348-21351 CC denotes and
T10714 21335-21347 RB denotes individually
T10713 21327-21334 VB denotes migrate
T10712 21321-21326 NN denotes cells
T10711 21314-21320 NN denotes glioma
T10710 21300-21313 JJ denotes WWOX-negative
T10709 21298-21299 -COMMA- denotes ,
T10708 21287-21298 RB denotes Conceivably
T10631 20792-20798 RB denotes rather
T10630 20779-20791 RB denotes individually
T10629 20771-20778 VB denotes migrate
T10628 20769-20770 -COMMA- denotes ,
T10627 20759-20769 NN denotes properties
T10626 20749-20758 JJ denotes cell-like
T10625 20744-20748 NN denotes stem
T10624 20739-20743 IN denotes with
T10623 20737-20738 -COMMA- denotes ,
T10622 20732-20737 NN denotes cells
T10621 20725-20731 NN denotes glioma
T10620 20720-20724 IN denotes that
T10619 20712-20719 VB denotes believe
T10618 20709-20711 PRP denotes We
T10617 20706-20707 -RRB- denotes )
T10616 20702-20706 CD denotes 2012
T10615 20700-20701 -COMMA- denotes ,
T10614 20697-20700 FW denotes al.
T10613 20694-20696 FW denotes et
T10612 20688-20693 NNP denotes Chang
T10611 20687-20688 -LRB- denotes (
T10610 20681-20686 NN denotes cells
T10609 20674-20680 NN denotes cancer
T10608 20671-20673 IN denotes in
T10607 20661-20670 NN denotes apoptosis
T10606 20654-20660 VB denotes causes
T10605 20650-20653 CC denotes and
T10604 20640-20649 NN denotes migration
T10603 20635-20639 NN denotes cell
T10602 20631-20634 CC denotes and
T10601 20624-20630 NN denotes growth
T10600 20602-20623 JJ denotes anchorage-independent
T10599 20591-20601 VB denotes suppresses
T10598 20586-20590 NN denotes WWOX
T10597 20582-20585 CC denotes and
T10596 20580-20581 -COMMA- denotes ,
T10595 20577-20580 NN denotes p53
T10594 20575-20576 -COMMA- denotes ,
T10593 20574-20575 -RRB- denotes )
T10592 20568-20574 NN denotes factor
T10591 20554-20567 JJ denotes antiapoptotic
T10590 20540-20553 JJ denotes TGF-β-induced
T10589 20539-20540 -LRB- denotes (
T10588 20533-20538 NN denotes TIAF1
T10587 20530-20532 IN denotes of
T10586 20519-20529 NN denotes expression
T10585 20511-20518 JJ denotes Ectopic
T10584 20508-20509 -RRB- denotes )
T10583 20504-20508 CD denotes 2011
T10582 20502-20503 -COMMA- denotes ,
T10581 20499-20502 FW denotes al.
T10580 20496-20498 FW denotes et
T10579 20491-20495 NNP denotes Mare
T10578 20487-20490 NNP denotes Del
T10935 22635-22640 NN denotes cells
T10934 22628-22634 NN denotes cancer
T10933 22625-22627 IN denotes in
T10932 22614-22624 NN denotes resistance
T10931 22610-22613 NN denotes TMZ
T10930 22606-22609 CC denotes and
T10929 22595-22605 NN denotes deficiency
T10928 22590-22594 NN denotes WWOX
T10927 22587-22589 IN denotes of
T10926 22579-22586 NN denotes effects
T10925 22575-22578 DT denotes the
T10924 22565-22574 VB denotes discussed
T10577 20485-20486 -COLON- denotes ;
T10576 20481-20485 CD denotes 2009
T10575 20479-20480 -COMMA- denotes ,
T10574 20476-20479 FW denotes al.
T10573 20473-20475 FW denotes et
T10572 20465-20472 NNP denotes Gourley
T10571 20464-20465 -LRB- denotes (
T10570 20458-20463 NN denotes cells
T10569 20445-20457 NN denotes osteosarcoma
T10568 20441-20444 CC denotes and
T10567 20434-20440 NN denotes cancer
T10566 20426-20433 JJ denotes ovarian
T10565 20423-20425 IN denotes of
T10564 20413-20422 NN denotes migration
T10563 20401-20412 VB denotes facilitates
T10562 20396-20400 NN denotes WWOX
T10561 20393-20395 IN denotes of
T10560 20388-20392 NN denotes loss
T10559 20386-20387 -COMMA- denotes ,
T10558 20379-20386 NN denotes example
T10557 20375-20378 IN denotes For
T10556 20364-20373 NN denotes migration
T10555 20359-20363 NN denotes cell
T10554 20351-20358 VB denotes enhance
T10553 20348-20350 TO denotes to
T10552 20339-20347 VB denotes expected
T10551 20336-20338 VB denotes is
T10550 20325-20335 NN denotes expression
T10549 20320-20324 NN denotes WWOX
T10548 20317-20319 IN denotes of
T10547 20312-20316 NN denotes lack
T10546 20310-20311 -COMMA- denotes ,
T10545 20306-20310 RB denotes Also
T10544 20303-20304 -RRB- denotes )
T10543 20299-20303 CD denotes 2012
T10542 20297-20298 -COMMA- denotes ,
T10541 20294-20297 FW denotes al.
T10540 20291-20293 FW denotes et
T10539 20282-20290 NNP denotes Hagemann
T10538 20280-20281 -COLON- denotes ;
T10537 20276-20280 CD denotes 2003
T10536 20274-20275 -COMMA- denotes ,
T10535 20271-20274 FW denotes al.
T10534 20268-20270 FW denotes et
T10533 20261-20267 NNP denotes Junker
T10532 20259-20260 -COLON- denotes ;
T10531 20255-20259 CD denotes 2002
T10530 20253-20254 -COMMA- denotes ,
T10529 20250-20253 FW denotes al.
T10528 20247-20249 FW denotes et
T10527 20239-20246 NNP denotes Delpech
T10526 20238-20239 -LRB- denotes (
T10525 20228-20237 NN denotes migration
T10524 20222-20227 PRP-DOLLAR- denotes their
T10523 20211-20221 VB denotes facilitate
T10522 20208-20210 TO denotes to
T10521 20189-20207 NN denotes metalloproteinases
T10520 20185-20188 CC denotes and
T10519 20170-20184 NN denotes hyaluronidases
T10518 20162-20169 JJ denotes secrete
T10517 20158-20161 CC denotes and
T10516 20156-20157 -COMMA- denotes ,
T10515 20155-20156 -RRB- denotes )
T10514 20151-20155 CD denotes 2012
T10513 20149-20150 -COMMA- denotes ,
T10512 20146-20149 FW denotes al.
T10511 20143-20145 FW denotes et
T10510 20135-20142 NNP denotes Yoshida
T10509 20133-20134 -COLON- denotes ;
T10508 20129-20133 CD denotes 2004
T10507 20127-20128 -COMMA- denotes ,
T10506 20124-20127 FW denotes al.
T10505 20121-20123 FW denotes et
T10504 20115-20120 NNP denotes Murai
T10503 20114-20115 -LRB- denotes (
T10502 20103-20113 NN denotes hyaluronan
T10501 20096-20102 NN denotes matrix
T10500 20090-20095 NN denotes brain
T10499 20085-20089 IN denotes with
T10498 20073-20084 VB denotes interacting
T10497 20069-20072 IN denotes for
T10496 20060-20068 NN denotes receptor
T10495 20058-20059 DT denotes a
T10494 20055-20057 IN denotes as
T10493 20050-20054 NN denotes CD44
T10492 20042-20049 VB denotes possess
T10491 20036-20041 NN denotes cells
T10490 20029-20035 NN denotes Glioma
T10489 20026-20027 -RRB- denotes )
T10488 20022-20026 CD denotes 2005
T10487 20020-20021 -COMMA- denotes ,
T10486 20017-20020 FW denotes al.
T10485 20014-20016 FW denotes et
T10484 20006-20013 NNP denotes Lefranc
T10483 20005-20006 -LRB- denotes (
T10482 19999-20004 NN denotes death
T10481 19989-19998 JJ denotes apoptotic
T10480 19986-19988 TO denotes to
T10479 19976-19985 JJ denotes resistant
T10478 19970-19975 NN denotes cells
T10477 19960-19969 VB denotes migrating
T10476 19954-19959 DT denotes these
T10475 19947-19953 VB denotes confer
T10474 19944-19946 TO denotes to
T10473 19935-19943 VB denotes believed
T10472 19931-19934 VB denotes are
T10471 19929-19930 -COMMA- denotes ,
T10470 19920-19929 NN denotes autophagy
T10469 19916-19919 CC denotes and
T10468 19914-19915 -COMMA- denotes ,
T10467 19909-19914 NN denotes NF-κB
T10466 19907-19908 -COMMA- denotes ,
T10465 19903-19907 NN denotes mTOR
T10464 19901-19902 -COMMA- denotes ,
T10463 19898-19901 NN denotes Akt
T10462 19896-19897 -COMMA- denotes ,
T10461 19892-19896 NN denotes PI3K
T10460 19882-19891 VB denotes involving
T10459 19880-19881 -COMMA- denotes ,
T10458 19872-19880 NN denotes pathways
T10457 19865-19871 NN denotes Signal
T10456 19857-19863 NN denotes tissue
T10455 19851-19856 NN denotes brain
T10454 19843-19850 JJ denotes distant
T10453 19838-19842 IN denotes into
T10452 19825-19837 NN denotes infiltration
T10451 19817-19824 JJ denotes diffuse
T10450 19811-19816 PRP-DOLLAR- denotes their
T10449 19808-19810 VB denotes is
T10448 19800-19807 NN denotes gliomas
T10447 19790-19799 JJ denotes malignant
T10446 19786-19789 IN denotes for
T10445 19770-19785 NN denotes characteristics
T10444 19763-19769 JJ denotes unique
T10443 19759-19762 DT denotes the
T10442 19756-19758 IN denotes of
T10441 19752-19755 CD denotes One
T10440 19739-19750 VB denotes established
T10439 19736-19738 VB denotes be
T10438 19733-19735 TO denotes to
T10437 19725-19732 VB denotes remains
T10436 19721-19724 CC denotes and
T10435 19713-19720 JJ denotes unknown
T10434 19710-19712 VB denotes is
T10433 19706-19709 NN denotes p53
T10432 19695-19705 JJ denotes endogenous
T10431 19692-19694 IN denotes of
T10430 19683-19691 NN denotes function
T10429 19679-19682 DT denotes the
T10428 19674-19678 IN denotes with
T10427 19662-19673 VB denotes counteracts
T10426 19657-19661 NN denotes WWOX
T10425 19646-19656 JJ denotes endogenous
T10424 19638-19645 IN denotes Whether
T10423 19630-19636 NN denotes growth
T10422 19623-19629 NN denotes cancer
T10421 19614-19622 VB denotes allowing
T10420 19609-19613 RB denotes thus
T10419 19607-19608 -COMMA- denotes ,
T10418 19599-19607 NN denotes function
T10417 19591-19598 NN denotes other’s
T10416 19586-19590 DT denotes each
T10313 19015-19017 VB denotes is
T10312 19006-19014 NN denotes scenario
T10311 18999-19005 JJ denotes likely
T10310 18997-18998 DT denotes A
T10309 18994-18995 -RRB- denotes )
T10308 18990-18994 CD denotes 2012
T10307 18988-18989 -COMMA- denotes ,
T10306 18985-18988 FW denotes al.
T10305 18982-18984 FW denotes et
T10304 18979-18981 NNP denotes Su
T10303 18977-18978 -COLON- denotes ;
T10302 18973-18977 CD denotes 2012
T10301 18971-18972 -COMMA- denotes ,
T10300 18967-18971 CD denotes 2010
T10299 18965-18966 -COMMA- denotes ,
T10298 18961-18965 CD denotes 2007
T10297 18959-18960 -COMMA- denotes ,
T10296 18958-18959 NN denotes b
T10295 18957-18958 -COMMA- denotes ,
T10294 18952-18957 NN denotes 2005a
T10293 18950-18951 -COMMA- denotes ,
T10292 18946-18950 CD denotes 2003
T10291 18944-18945 -COMMA- denotes ,
T10290 18940-18944 CD denotes 2001
T10289 18938-18939 -COMMA- denotes ,
T10288 18935-18938 FW denotes al.
T10287 18932-18934 FW denotes et
T10286 18926-18931 NNP denotes Chang
T10285 18925-18926 -LRB- denotes (
T10284 18918-18924 NN denotes manner
T10283 18906-18917 JJ denotes synergistic
T10282 18904-18905 DT denotes a
T10281 18901-18903 IN denotes in
T10280 18891-18900 NN denotes apoptosis
T10279 18884-18890 VB denotes induce
T10278 18875-18883 NN denotes proteins
T10277 18870-18874 DT denotes both
T10276 18866-18869 CC denotes and
T10275 18864-18865 -COMMA- denotes ,
T10274 18860-18864 NN denotes WWOX
T10273 18855-18859 IN denotes with
T10272 18845-18854 VB denotes interacts
T10271 18832-18844 RB denotes functionally
T10270 18828-18831 NN denotes p53
T10269 18823-18827 IN denotes that
T10268 18817-18822 VB denotes shown
T10267 18812-18816 VB denotes have
T10266 18809-18811 PRP denotes we
T10265 18807-18808 -COMMA- denotes ,
T10264 18802-18807 NN denotes cases
T10263 18797-18801 JJ denotes most
T10262 18794-18796 IN denotes In
T10261 18791-18792 -RRB- denotes )
T10260 18787-18791 CD denotes 2012
T10707 21280-21285 NN denotes cells
T10706 21266-21279 JJ denotes WWOX-positive
T10705 21262-21265 DT denotes the
T10704 21257-21261 IN denotes from
T10703 21252-21256 RB denotes away
T10702 21247-21251 VB denotes move
T10701 21244-21246 TO denotes to
T10700 21238-21243 NN denotes cells
T10699 21224-21237 JJ denotes WWOX-negative
T10698 21221-21223 IN denotes of
T10697 21212-21220 NN denotes mobility
T10696 21208-21211 DT denotes the
T10695 21198-21207 VB denotes increases
T10694 21193-21197 DT denotes this
T10693 21189-21192 CC denotes and
T10692 21187-21188 -COMMA- denotes ,
T10691 21182-21187 NN denotes cells
T10690 21168-21181 JJ denotes WWOX-positive
T10689 21159-21167 JJ denotes parental
T10688 21156-21158 IN denotes by
T10687 21144-21155 NN denotes recognition
T10686 21139-21143 VB denotes lose
T10685 21133-21138 NN denotes cells
T10684 21119-21132 JJ denotes WWOX-negative
T10683 21117-21118 -COMMA- denotes ,
T10682 21096-21117 NN denotes membrane/cytoskeleton
T10681 21091-21095 NN denotes cell
T10680 21087-21090 DT denotes the
T10679 21084-21086 IN denotes on
T10678 21075-21083 VB denotes anchored
T10677 21072-21074 VB denotes is
T10676 21067-21071 NN denotes WWOX
T10675 21064-21066 IN denotes of
T10674 21056-21063 NN denotes portion
T10673 21054-21055 DT denotes a
T10672 21048-21053 IN denotes While
T10671 21045-21046 -RRB- denotes )
T10670 21034-21045 JJ denotes unpublished
T10669 21032-21033 -COMMA- denotes ,
T10668 21029-21032 FW denotes al.
T10667 21026-21028 FW denotes et
T10666 21021-21025 NNP denotes Chou
T10665 21020-21021 -LRB- denotes (
T10664 21007-21019 RB denotes collectively
T10663 20999-21006 VB denotes migrate
T10662 20993-20998 NN denotes cells
T10661 20988-20992 NN denotes type
T10660 20983-20987 JJ denotes wild
T10659 20981-20982 -COMMA- denotes ,
T10658 20973-20981 NN denotes contrast
T10657 20970-20972 IN denotes In
T10656 20956-20968 RB denotes aggressively
T10655 20952-20955 CC denotes and
T10654 20939-20951 RB denotes individually
T10653 20931-20938 VB denotes migrate
T10652 20929-20930 -RRB- denotes )
T10651 20918-20929 NN denotes fibroblasts
T10650 20908-20917 JJ denotes embryonic
T10649 20906-20907 -COMMA- denotes ,
T10648 20902-20906 FW denotes e.g.
T10647 20901-20902 -LRB- denotes (
T10646 20895-20900 NN denotes cells
T10645 20886-20894 NN denotes knockout
T10644 20881-20885 NN denotes gene
T10643 20876-20880 NN denotes Wwox
T10642 20870-20875 NN denotes mouse
T10641 20865-20869 IN denotes that
T10640 20852-20864 NN denotes observations
T10639 20848-20851 PRP-DOLLAR- denotes our
T10638 20843-20847 IN denotes upon
T10637 20837-20842 VB denotes based
T10636 20834-20836 VB denotes is
T10635 20823-20833 NN denotes assumption
T10634 20818-20822 DT denotes This
T10633 20804-20816 RB denotes collectively
T10632 20799-20803 IN denotes than
T10259 18785-18786 -COMMA- denotes ,
T10258 18782-18785 FW denotes al.
T10257 18779-18781 FW denotes et
T10256 18772-18778 NNP denotes Chiang
T10255 18771-18772 -LRB- denotes (
T10254 18763-18770 JJ denotes unusual
T10253 18760-18762 VB denotes is
T10252 18756-18759 NN denotes p53
T10251 18751-18755 NN denotes type
T10250 18746-18750 JJ denotes wild
T10249 18735-18745 VB denotes possessing
T10248 18729-18734 NN denotes cells
T10247 18722-18728 NN denotes glioma
T10246 18719-18721 IN denotes of
T10245 18709-18718 NN denotes apoptosis
T10244 18700-18708 VB denotes inducing
T10243 18697-18699 IN denotes in
T10242 18692-18696 NN denotes WWOX
T10241 18684-18691 JJ denotes ectopic
T10240 18681-18683 IN denotes of
T10239 18673-18680 NN denotes Failure
T10238 18662-18671 NN denotes apoptosis
T10237 18653-18661 VB denotes inducing
T10236 18649-18652 IN denotes for
T10235 18639-18648 VB denotes activated
T10234 18636-18638 VB denotes is
T10233 18631-18635 NN denotes WWOX
T10232 18623-18630 JJ denotes ectopic
T10231 18621-18622 -COMMA- denotes ,
T10230 18616-18621 NN denotes event
T10229 18611-18615 DT denotes this
T10228 18608-18610 IN denotes In
T10227 18605-18606 -RRB- denotes )
T10226 18601-18605 CD denotes 2009
T10225 18599-18600 -COMMA- denotes ,
T10224 18596-18599 FW denotes al.
T10223 18593-18595 FW denotes et
T10222 18588-18592 NNP denotes Hong
T10221 18587-18588 -LRB- denotes (
T10220 18579-18586 NN denotes pathway
T10219 18568-18578 NN denotes activation
T10218 18558-18567 JJ denotes classical
T10217 18554-18557 DT denotes the
T10216 18551-18553 IN denotes in
T10215 18542-18550 NN denotes proteins
T10214 18531-18541 JJ denotes downstream
T10213 18528-18530 IN denotes of
T10212 18514-18527 NN denotes participation
T10211 18506-18513 IN denotes without
T10210 18500-18505 NN denotes cells
T10209 18485-18499 NN denotes neuroblastomas
T10208 18481-18484 CC denotes and
T10207 18474-18480 NN denotes cancer
T10206 18465-18473 NN denotes prostate
T10205 18462-18464 IN denotes of
T10204 18452-18461 NN denotes apoptosis
T10203 18444-18451 VB denotes induces
T10202 18440-18443 NN denotes C1q
T10201 18429-18439 NN denotes complement
T10200 18423-18428 NN denotes serum
T10199 18421-18422 -COMMA- denotes ,
T10198 18414-18421 NN denotes example
T10197 18410-18413 IN denotes For
T10196 18402-18408 NN denotes growth
T10195 18395-18401 NN denotes cancer
T10194 18386-18394 VB denotes blocking
T10193 18382-18385 IN denotes for
T10192 18373-18381 VB denotes utilized
T10191 18370-18372 VB denotes be
T10190 18366-18369 MD denotes can
T10189 18358-18365 NN denotes factors
T10188 18352-18357 NN denotes Serum
T10187 18349-18350 -RRB- denotes )
T10186 18345-18349 CD denotes 2012
T10185 18343-18344 -COMMA- denotes ,
T10184 18340-18343 FW denotes al.
T10183 18337-18339 FW denotes et
T10182 18332-18336 NNP denotes Holt
T10181 18331-18332 -LRB- denotes (
T10180 18326-18330 FW denotes vivo
T10179 18323-18325 FW denotes in
T10178 18317-18322 NN denotes death
T10177 18312-18316 NN denotes cell
T10176 18305-18311 NN denotes cancer
T10175 18293-18304 JJ denotes TMZ-induced
T10174 18284-18292 VB denotes enhances
T10173 18272-18283 NN denotes selumetinib
T10172 18269-18271 IN denotes by
T10171 18265-18268 NN denotes MEK
T10170 18262-18264 IN denotes of
T10169 18251-18261 NN denotes inhibition
T10168 18242-18250 JJ denotes specific
T10167 18240-18241 -COMMA- denotes ,
T10166 18234-18240 RB denotes Indeed
T10165 18231-18232 -RRB- denotes )
T10164 18220-18231 JJ denotes unpublished
T10163 18218-18219 -COMMA- denotes ,
T10162 18215-18218 FW denotes al.
T10161 18212-18214 FW denotes et
T10160 18209-18211 FW denotes Lu
T10159 18208-18209 -LRB- denotes (
T10158 18202-18207 NN denotes cells
T10157 18195-18201 NN denotes cancer
T10156 18192-18194 IN denotes of
T10155 18186-18191 NN denotes types
T10154 18181-18185 JJ denotes many
T10153 18178-18180 IN denotes of
T10152 18168-18177 NN denotes apoptosis
T10151 18161-18167 VB denotes induce
T10150 18156-18160 WDT denotes that
T10149 18146-18155 NN denotes molecules
T10148 18140-18145 JJ denotes small
T10147 18132-18139 JJ denotes certain
T10146 18123-18131 VB denotes selected
T10145 18118-18122 VB denotes have
T10144 18108-18117 NN denotes chemicals
T10143 18105-18107 IN denotes of
T10142 18095-18104 NN denotes screening
T10141 18091-18094 PRP-DOLLAR- denotes our
T10140 18086-18090 IN denotes from
T10139 18078-18085 NN denotes studies
T10138 18066-18077 JJ denotes Preliminary
T10137 18059-18064 NN denotes death
T10136 18054-18058 NN denotes cell
T10135 18050-18053 NN denotes GBM
T10134 18044-18049 VB denotes cause
T10133 18041-18043 TO denotes to
T10132 18032-18040 VB denotes expected
T10131 18028-18031 VB denotes are
T10130 18026-18027 -COMMA- denotes ,
T10129 18019-18026 NN denotes complex
T10128 18010-18018 NN denotes WWOX/MEK
T10127 18006-18009 DT denotes the
T10126 18000-18005 RP denotes apart
T10125 17994-17999 VB denotes break
T10124 17988-17993 WDT denotes which
T10123 17986-17987 -COMMA- denotes ,
T10122 17977-17986 NN denotes chemicals
T10121 17965-17976 JJ denotes appropriate
T10120 17963-17964 -COMMA- denotes ,
T10119 17959-17963 RB denotes Thus
T10118 17956-17957 -RRB- denotes )
T10117 17952-17956 CD denotes 2011
T10116 17950-17951 -COMMA- denotes ,
T10115 17947-17950 FW denotes al.
T10114 17944-17946 FW denotes et
T10113 17940-17943 NNP denotes Lin
T10112 17939-17940 -LRB- denotes (
T10111 17933-17938 NN denotes cells
T10110 17924-17932 NN denotes leukemia
T10109 17922-17923 NN denotes T
T10108 17919-17921 IN denotes of
T10107 17909-17918 NN denotes apoptosis
T10106 17901-17908 VB denotes causing
T10105 17897-17900 IN denotes for
T10104 17889-17896 NN denotes complex
T10103 17884-17888 DT denotes this
T10102 17872-17883 VB denotes dissociates
T10101 17868-17871 NN denotes PMA
T10100 17863-17867 IN denotes that
T10099 17859-17862 CC denotes and
T10098 17857-17858 -COMMA- denotes ,
T10415 19575-19585 VB denotes counteract
T10414 19570-19574 PRP denotes they
T10413 19567-19569 VB denotes do
T10412 19565-19566 -COMMA- denotes ,
T10411 19563-19565 CC denotes Or
T10410 19551-19561 RB denotes eventually
T10409 19543-19550 NN denotes control
T10408 19538-19542 VB denotes lose
T10407 19534-19537 CC denotes but
T10406 19522-19533 NN denotes progression
T10405 19515-19521 NN denotes cancer
T10404 19506-19514 VB denotes blocking
T10403 19503-19505 IN denotes in
T10402 19487-19502 RB denotes synergistically
T10401 19483-19486 VB denotes act
T10400 19474-19482 NN denotes proteins
T10399 19468-19473 DT denotes these
T10398 19465-19467 VB denotes Do
T10397 19462-19463 -RRB- denotes )
T10396 19451-19462 JJ denotes unpublished
T10395 19449-19450 -COMMA- denotes ,
T10394 19446-19449 FW denotes al.
T10393 19443-19445 FW denotes et
T10392 19437-19442 NNP denotes Chang
T10391 19435-19436 -COLON- denotes ;
T10390 19431-19435 CD denotes 2005
T10389 19429-19430 -COMMA- denotes ,
T10388 19426-19429 FW denotes al.
T10387 19423-19425 FW denotes et
T10386 19419-19422 NNP denotes Lai
T10385 19418-19419 -LRB- denotes (
T10384 19406-19417 NN denotes progression
T10383 19399-19405 NN denotes cancer
T10382 19396-19398 IN denotes of
T10381 19390-19395 NN denotes stage
T10380 19384-19389 JJ denotes early
T10379 19380-19383 DT denotes the
T10378 19373-19379 IN denotes during
T10377 19361-19372 VB denotes upregulated
T10376 19347-19360 RB denotes significantly
T10375 19343-19346 VB denotes are
T10374 19341-19342 -COMMA- denotes ,
T10373 19337-19341 FW denotes etc.
T10372 19333-19336 CC denotes and
T10371 19331-19332 -COMMA- denotes ,
T10370 19327-19331 NN denotes PP2A
T10369 19325-19326 -COMMA- denotes ,
T10368 19321-19325 NN denotes PTEN
T10367 19319-19320 -COMMA- denotes ,
T10366 19314-19319 NN denotes Smad4
T10365 19312-19313 -COMMA- denotes ,
T10364 19308-19312 NN denotes WWOX
T10363 19306-19307 -COMMA- denotes ,
T10362 19303-19306 NN denotes p53
T10361 19301-19302 -COMMA- denotes ,
T10360 19297-19301 FW denotes e.g.
T10359 19295-19296 -COMMA- denotes ,
T10358 19287-19295 NN denotes proteins
T10357 19276-19286 NN denotes suppressor
T10356 19270-19275 NN denotes tumor
T10355 19265-19269 JJ denotes many
T10354 19260-19264 IN denotes that
T10353 19255-19259 VB denotes find
T10352 19252-19254 TO denotes to
T10351 19241-19251 JJ denotes surprising
T10350 19237-19240 RB denotes not
T10349 19234-19236 VB denotes is
T10348 19231-19233 PRP denotes it
T10347 19229-19230 -COMMA- denotes ,
T10346 19222-19229 RB denotes However
T10345 19210-19220 NN denotes literature
T10344 19206-19209 DT denotes the
T10343 19203-19205 IN denotes in
T10342 19192-19202 VB denotes documented
T10341 19187-19191 VB denotes been
T10340 19181-19186 RB denotes never
T10339 19177-19180 VB denotes has
T10338 19165-19176 NN denotes suppressors
T10337 19159-19164 NN denotes tumor
T10336 19153-19158 IN denotes among
T10335 19142-19152 NN denotes antagonism
T10334 19131-19141 JJ denotes Functional
T10333 19126-19129 NN denotes p53
T10332 19122-19125 CC denotes and
T10331 19117-19121 NN denotes WWOX
T10330 19114-19116 IN denotes of
T10329 19105-19113 NN denotes function
T10328 19095-19104 JJ denotes apoptotic
T10327 19091-19094 DT denotes the
T10326 19086-19090 IN denotes with
T10325 19076-19085 VB denotes interfere
T10324 19072-19075 MD denotes may
T10323 19070-19071 -COMMA- denotes ,
T10322 19066-19070 NN denotes GBMs
T10321 19063-19065 IN denotes in
T10320 19055-19062 JJ denotes present
T10319 19051-19054 VB denotes are
T10318 19045-19050 WDT denotes which
T10317 19043-19044 -COMMA- denotes ,
T10316 19035-19043 NN denotes proteins
T10315 19023-19034 JJ denotes p53-binding
T10314 19018-19022 IN denotes that
T10085 17782-17788 JJ denotes likely
T10084 17778-17781 VB denotes are
T10083 17774-17777 NN denotes p53
T10082 17767-17773 CC denotes and/or
T10081 17762-17766 NN denotes WWOX
T10080 17758-17761 IN denotes for
T10079 17749-17757 NN denotes proteins
T10078 17741-17748 NN denotes Binding
T10077 17729-17739 VB denotes determined
T10076 17724-17728 VB denotes been
T10075 17718-17723 RB denotes never
T10074 17714-17717 VB denotes has
T10073 17702-17713 NN denotes sensitivity
T10072 17698-17701 NN denotes TMZ
T10071 17690-17697 VB denotes affects
T10070 17685-17689 NN denotes WWOX
T10069 17677-17684 IN denotes Whether
T10097 17854-17857 NN denotes MEK
T10096 17848-17853 VB denotes binds
T10095 17843-17847 NN denotes WWOX
T10094 17836-17841 NN denotes cells
T10093 17832-17835 NN denotes GBM
T10092 17829-17831 IN denotes in
T10091 17817-17828 NN denotes sensitivity
T10090 17813-17816 NN denotes TMZ
T10089 17809-17812 CC denotes and
T10088 17799-17808 NN denotes apoptosis
T10087 17792-17798 VB denotes affect
T10086 17789-17791 TO denotes to
T8854 17647-17649 VB denotes be
T8853 17644-17646 TO denotes to
T8852 17636-17643 VB denotes remains
T8851 17632-17635 CC denotes and
T8850 17624-17631 JJ denotes unknown
T8849 17621-17623 VB denotes is
T8848 17612-17620 NN denotes isoforms
T8847 17608-17611 NN denotes p53
T8846 17597-17607 VB denotes expressing
T8845 17593-17596 NN denotes GBM
T8844 17590-17592 IN denotes in
T8843 17580-17589 NN denotes apoptosis
T8842 17573-17579 VB denotes causes
T8841 17568-17572 NN denotes WWOX
T8840 17560-17567 IN denotes Whether
T8839 17549-17558 NN denotes apoptosis
T8838 17542-17548 VB denotes induce
T8837 17539-17541 TO denotes to
T8836 17534-17538 JJ denotes able
T8835 17531-17533 VB denotes is
T8834 17526-17530 NN denotes WWOX
T8833 17522-17525 CC denotes and
T8832 17520-17521 -COMMA- denotes ,
T8831 17515-17520 NN denotes cells
T8830 17511-17514 NN denotes GBM
T8829 17508-17510 IN denotes in
T8828 17503-17507 NN denotes WWOX
T8827 17495-17502 JJ denotes ectopic
T8826 17490-17494 VB denotes bind
T8825 17486-17489 RB denotes not
T8824 17483-17486 MD denotes can
T8823 17474-17482 NN denotes proteins
T8822 17470-17473 NN denotes p53
T8821 17463-17469 JJ denotes Mutant
T8820 17460-17461 -RRB- denotes )
T8819 17459-17460 CD denotes 2
T8818 17452-17458 NN denotes Figure
T8817 17451-17452 -LRB- denotes (
T8816 17441-17450 NN denotes apoptosis
T8815 17432-17440 VB denotes inducing
T8814 17429-17431 IN denotes in
T8813 17420-17428 VB denotes function
T8812 17412-17419 NN denotes other’s
T8811 17407-17411 DT denotes each
T8810 17396-17406 VB denotes nullifying
T8809 17388-17395 RB denotes thereby
T8808 17386-17387 -COMMA- denotes ,
T8807 17376-17386 NN denotes antagonism
T8806 17365-17375 JJ denotes functional
T8805 17363-17364 DT denotes a
T8804 17358-17362 VB denotes have
T8803 17355-17357 TO denotes to
T8802 17348-17354 VB denotes appear
T8801 17339-17347 NN denotes proteins
T8800 17334-17338 NN denotes WWOX
T8799 17326-17333 JJ denotes ectopic
T8798 17322-17325 CC denotes and
T8797 17318-17321 NN denotes p53
T8796 17313-17317 NN denotes type
T8795 17308-17312 JJ denotes wild
T8794 17303-17307 DT denotes both
T8793 17301-17302 -COMMA- denotes ,
T8792 17296-17301 NN denotes cells
T8791 17292-17295 NN denotes GBM
T8790 17289-17291 IN denotes in
T8635 16340-16342 IN denotes of
T8634 16325-16339 NN denotes downregulation
T8633 16319-16324 WDT denotes which
T8632 16316-16318 IN denotes in
T8631 16314-16315 -COMMA- denotes ,
T8630 16310-16314 NN denotes GBMs
T8629 16307-16309 IN denotes in
T8628 16301-16306 VB denotes shown
T8627 16298-16300 VB denotes is
T8626 16287-16297 NN denotes expression
T8625 16282-16286 NN denotes WWOX
T8624 16274-16281 VB denotes Altered
T8623 16262-16263 -RRB- denotes a
T8622 16257-16261 CD denotes h et
T8621 16256-16257 -COMMA- denotes g
T8620 16253-16256 FW denotes lou
T8619 16251-16253 FW denotes (B
T8618 16244-16250 NNP denotes liomas
T8617 16243-16244 -LRB- denotes g
T8616 16235-16242 NN denotes vity in
T8615 16233-16235 IN denotes ti
T8614 16222-16233 NN denotes e TMZ sensi
T8613 16219-16222 NN denotes duc
T8612 16213-16219 VB denotes nts re
T8611 16206-16213 NN denotes 53 muta
T8610 16203-16206 NN denotes . p
T8609 16202-16203 -RRB- denotes )
T8608 16198-16202 CD denotes 2011
T8607 16196-16197 -COMMA- denotes ,
T8606 16193-16196 FW denotes al.
T8605 16190-16192 FW denotes et
T8604 16183-16189 NNP denotes Blough
T8603 16182-16183 -LRB- denotes (
T8602 16171-16181 NN denotes resistance
T8601 16167-16170 NN denotes TMZ
T8600 16163-16166 DT denotes the
T8599 16153-16162 VB denotes increases
T8598 16149-16152 NN denotes p53
T8597 16144-16148 NN denotes type
T8596 16139-16143 JJ denotes wild
T8595 16131-16138 IN denotes whereas
T8594 16129-16130 -COMMA- denotes ,
T8593 16124-16129 NN denotes cells
T8592 16117-16123 NN denotes glioma
T8591 16114-16116 IN denotes in
T8590 16110-16113 NN denotes TMZ
T8589 16107-16109 TO denotes to
T8588 16095-16106 NN denotes sensitivity
T8587 16087-16094 VB denotes confers
T8586 16083-16086 NN denotes p53
T8585 16072-16082 JJ denotes functional
T8584 16069-16071 IN denotes of
T8583 16064-16068 NN denotes Loss
T8582 16061-16062 -RRB- denotes )
T8581 16057-16061 CD denotes 2011
T8580 16055-16056 -COMMA- denotes ,
T8579 16052-16055 FW denotes al.
T8578 16049-16051 FW denotes et
T8577 16042-16048 NNP denotes Blough
T8576 16040-16041 -COLON- denotes ;
T8575 16036-16040 CD denotes 2010
T8574 16034-16035 -COMMA- denotes ,
T8573 16031-16034 FW denotes al.
T8572 16028-16030 FW denotes et
T8571 16018-16027 NNP denotes Squatrito
T8570 16016-16017 -COLON- denotes ;
T8569 16012-16016 CD denotes 2001
T8568 16010-16011 -COMMA- denotes ,
T8567 16007-16010 FW denotes al.
T8566 16004-16006 FW denotes et
T8565 15997-16003 NNP denotes Hirose
T8564 15995-15996 -COLON- denotes ;
T8563 15991-15995 CD denotes 1995
T8562 15989-15990 -COMMA- denotes ,
T8561 15986-15989 FW denotes al.
T8560 15983-15985 FW denotes et
T8559 15975-15982 NN denotes Gjerset
T8558 15974-15975 -LRB- denotes (
T8557 15968-15973 NN denotes cells
T8556 15961-15967 NN denotes glioma
T8555 15958-15960 IN denotes in
T8554 15948-15957 NN denotes treatment
T8553 15944-15947 NN denotes TMZ
T8552 15940-15943 CC denotes and
T8551 15927-15939 NN denotes radiotherapy
T8550 15924-15926 IN denotes in
T8549 15910-15923 NN denotes effectiveness
T8548 15906-15909 DT denotes the
T8547 15902-15905 IN denotes for
T8546 15894-15901 NN denotes factors
T8545 15882-15893 JJ denotes unfavorable
T8544 15879-15881 IN denotes as
T8543 15868-15878 VB denotes considered
T8542 15864-15867 VB denotes are
T8541 15856-15863 NN denotes mutants
T8540 15852-15855 NN denotes p53
T8789 17284-17288 IN denotes that
T8788 17274-17283 VB denotes postulate
T8787 17271-17273 PRP denotes We
T8786 17259-17269 VB denotes determined
T8785 17256-17258 VB denotes be
T8784 17253-17255 TO denotes to
T8783 17245-17252 VB denotes remains
T8782 17240-17244 NN denotes WWOX
T8781 17235-17239 IN denotes with
T8780 17227-17234 NN denotes protein
T8779 17222-17226 DT denotes this
T8778 17219-17221 IN denotes of
T8777 17211-17218 NN denotes binding
T8776 17209-17210 -COMMA- denotes ,
T8775 17203-17209 NN denotes Δ40p53
T8774 17200-17202 IN denotes in
T8773 17194-17199 NN denotes Ser46
T8772 17191-17193 IN denotes of
T8771 17182-17190 NN denotes presence
T8770 17178-17181 DT denotes the
T8769 17170-17177 IN denotes Despite
T8768 17156-17168 NN denotes interactions
T8767 17148-17155 NN denotes binding
T8766 17144-17147 DT denotes the
T8765 17135-17143 VB denotes enhances
T8764 17123-17134 NN denotes irradiation
T8763 17120-17122 NN denotes UV
T8762 17117-17118 -RRB- denotes )
T8761 17112-17117 NN denotes 2005b
T8760 17110-17111 -COMMA- denotes ,
T8759 17107-17110 FW denotes al.
T8758 17104-17106 FW denotes et
T8757 17098-17103 NNP denotes Chang
T8756 17097-17098 -LRB- denotes (
T8755 17081-17096 NN denotes phosphorylation
T8754 17075-17080 NN denotes Ser46
T8753 17070-17074 IN denotes with
T8752 17066-17069 NN denotes p53
T8751 17061-17065 NN denotes type
T8750 17056-17060 JJ denotes wild
T8749 17050-17055 VB denotes binds
T8748 17045-17049 NN denotes WWOX
T8747 17035-17044 VB denotes Activated
T8746 17029-17033 NN denotes WWOX
T8745 17025-17028 CC denotes and
T8744 17017-17024 NN denotes mutants
T8743 17013-17016 NN denotes p53
T8742 17010-17012 IN denotes of
T8741 16993-17009 NN denotes gain-of-function
T8740 16989-16992 DT denotes the
T8739 16981-16988 IN denotes between
T8738 16968-16980 NN denotes interactions
T8737 16963-16967 IN denotes upon
T8736 16955-16962 VB denotes depends
T8735 16949-16954 NN denotes cells
T8734 16936-16948 NN denotes glioblastoma
T8733 16930-16935 JJ denotes human
T8732 16927-16929 IN denotes of
T8731 16918-16926 NN denotes survival
T8730 16914-16917 DT denotes the
T8729 16909-16913 IN denotes that
T8728 16902-16908 VB denotes assume
T8727 16899-16901 TO denotes to
T8726 16888-16898 JJ denotes reasonable
T8725 16885-16887 VB denotes is
T8724 16882-16884 PRP denotes it
T8723 16880-16881 -COMMA- denotes ,
T8722 16873-16880 JJ denotes unknown
T8721 16869-16872 VB denotes are
T8720 16858-16868 NN denotes mechanisms
T8719 16847-16857 VB denotes underlying
T8718 16843-16846 DT denotes the
T8717 16837-16842 IN denotes While
T8716 16834-16835 -RRB- denotes )
T8715 16830-16834 CD denotes 2012
T8714 16828-16829 -COMMA- denotes ,
T8713 16825-16828 FW denotes al.
T8712 16822-16824 FW denotes et
T8711 16815-16821 NNP denotes Chiang
T8710 16814-16815 -LRB- denotes (
T8709 16806-16813 NN denotes pathway
T8708 16784-16805 JJ denotes caspase-3-independent
T8707 16780-16783 CC denotes and
T8706 16755-16779 JJ denotes mitochondria-independent
T8705 16753-16754 DT denotes a
T8704 16749-16752 IN denotes via
T8703 16743-16748 NN denotes cells
T8702 16735-16742 NN denotes U373-MG
T8701 16732-16734 IN denotes of
T8700 16722-16731 NN denotes apoptosis
T8699 16714-16721 VB denotes induces
T8698 16709-16713 NN denotes WWOX
T8697 16707-16708 -COMMA- denotes ,
T8696 16704-16707 NN denotes TMZ
T8695 16697-16703 IN denotes Unlike
T8694 16692-16695 NN denotes p53
T8693 16687-16691 NN denotes type
T8692 16682-16686 JJ denotes wild
T8691 16671-16681 VB denotes expressing
T8690 16664-16670 NN denotes U87-MG
T8689 16659-16663 IN denotes with
T8688 16652-16658 NN denotes effect
T8687 16649-16651 DT denotes no
T8686 16645-16648 VB denotes has
T8685 16640-16644 NN denotes WWOX
T8684 16632-16639 JJ denotes ectopic
T8683 16630-16631 -COMMA- denotes ,
T8682 16623-16630 RB denotes However
T8681 16620-16621 -RRB- denotes )
T8680 16616-16620 CD denotes 2012
T8679 16614-16615 -COMMA- denotes ,
T8678 16611-16614 FW denotes al.
T8677 16608-16610 FW denotes et
T8676 16601-16607 NNP denotes Chiang
T8675 16600-16601 -LRB- denotes (
T8674 16586-16599 NN denotes fragmentation
T8673 16582-16585 NN denotes DNA
T8672 16578-16581 CC denotes and
T8671 16567-16577 NN denotes hypoploidy
T8670 16559-16566 VB denotes causing
T8669 16556-16558 IN denotes by
T8668 16552-16555 NN denotes p53
T8667 16545-16551 JJ denotes mutant
T8666 16535-16544 VB denotes harboring
T8665 16529-16534 NN denotes cells
T8664 16521-16528 NN denotes U373-MG
T8663 16508-16520 NN denotes glioblastoma
T8662 16505-16507 IN denotes of
T8661 16495-16504 NN denotes apoptosis
T8660 16487-16494 VB denotes induces
T8659 16482-16486 NN denotes WWOX
T8658 16468-16481 VB denotes overexpressed
T8657 16463-16467 IN denotes that
T8656 16450-16462 VB denotes demonstrated
T8655 16447-16449 PRP denotes we
T8654 16445-16446 -COMMA- denotes ,
T8653 16437-16445 RB denotes Recently
T8652 16434-16435 -RRB- denotes )
T8651 16430-16434 CD denotes 2011
T8650 16428-16429 -COMMA- denotes ,
T8649 16425-16428 FW denotes al.
T8648 16422-16424 FW denotes et
T8647 16416-16421 NNP denotes Kosla
T8646 16415-16416 -LRB- denotes (
T8645 16403-16414 NN denotes methylation
T8644 16394-16402 NN denotes promoter
T8643 16390-16393 CC denotes and
T8642 16375-16389 NN denotes heterozygosity
T8641 16372-16374 IN denotes of
T8640 16367-16371 NN denotes loss
T8639 16362-16366 IN denotes with
T8638 16351-16361 VB denotes associated
T8637 16348-16350 VB denotes is
T8636 16343-16347 NN denotes WWOX
T7791 15807-15816 NN denotes apoptosis
T7790 15804-15806 IN denotes as
T7789 15799-15803 RB denotes well
T7788 15796-15798 RB denotes as
T7787 15794-15795 -COMMA- denotes ,
T7786 15785-15794 NN denotes promoters
T7785 15781-15784 NN denotes Bax
T7784 15777-15780 CC denotes and
T7743 15516-15528 JJ denotes p53-mediated
T7742 15505-15515 VB denotes suppresses
T7741 15497-15504 NN denotes Δ133p53
T7740 15492-15496 IN denotes with
T7739 15488-15491 NN denotes p53
T7738 15485-15487 IN denotes of
T7737 15471-15484 NN denotes co-expression
T7736 15463-15470 IN denotes whereas
T7735 15461-15462 -COMMA- denotes ,
T7734 15452-15461 NN denotes apoptosis
T7733 15439-15451 JJ denotes p53-mediated
T7732 15429-15438 VB denotes increases
T7731 15424-15428 NN denotes p53β
T7730 15420-15423 CC denotes and
T7729 15416-15419 NN denotes p53
T7728 15413-15415 IN denotes of
T7727 15397-15412 NN denotes Co-transfection
T7726 15394-15395 -RRB- denotes )
T7725 15390-15394 CD denotes 2005
T7724 15388-15389 -COMMA- denotes ,
T7723 15385-15388 FW denotes al.
T7722 15382-15384 FW denotes et
T7721 15374-15381 NNP denotes Bourdon
T7720 15373-15374 -LRB- denotes (
T7719 15363-15372 NN denotes cytoplasm
T7718 15359-15362 DT denotes the
T7717 15356-15358 IN denotes in
T7716 15346-15355 JJ denotes localized
T7715 15343-15345 VB denotes is
T7714 15334-15342 NN denotes Δ133p53γ
T7713 15323-15333 NN denotes cytoplasm.
T7712 15319-15322 CC denotes and
T7711 15311-15318 NN denotes nucleus
T7710 15307-15310 DT denotes the
T7709 15304-15306 IN denotes in
T7708 15294-15303 VB denotes localized
T7707 15290-15293 VB denotes are
T7706 15281-15289 NN denotes Δ133p53β
T7705 15277-15280 CC denotes and
T7704 15272-15276 NN denotes p53γ
T7703 15261-15271 NN denotes cytoplasm.
T7702 15258-15260 IN denotes in
T7701 15254-15257 VB denotes are
T7700 15249-15253 PRP denotes them
T7699 15246-15248 IN denotes of
T7698 15242-15245 JJ denotes few
T7697 15237-15241 RB denotes only
T7696 15233-15236 CC denotes and
T7695 15231-15232 -COMMA- denotes ,
T7694 15224-15231 NN denotes nucleus
T7693 15220-15223 DT denotes the
T7692 15217-15219 IN denotes in
T7691 15210-15216 RB denotes mainly
T7690 15200-15209 VB denotes localized
T7689 15196-15199 VB denotes are
T7688 15191-15195 NN denotes p53β
T7687 15187-15190 CC denotes and
T7686 15185-15186 -COMMA- denotes ,
T7685 15178-15185 NN denotes Δ133p53
T7684 15176-15177 -COMMA- denotes ,
T7683 15173-15176 NN denotes p53
T7682 15161-15172 JJ denotes Full-length
T7681 15158-15159 -RRB- denotes )
T7680 15154-15158 CD denotes 2007
T7679 15152-15153 -COMMA- denotes ,
T7678 15145-15152 NNP denotes Bourdon
T7677 15143-15144 -COLON- denotes ;
T7676 15139-15143 CD denotes 2005
T7675 15137-15138 -COMMA- denotes ,
T7674 15134-15137 FW denotes al.
T7673 15131-15133 FW denotes et
T7672 15123-15130 NNP denotes Bourdon
T7671 15122-15123 -LRB- denotes (
T7670 15111-15121 RB denotes frequently
T7669 15104-15110 VB denotes occurs
T7668 15095-15103 NN denotes isoforms
T7667 15091-15094 NN denotes p53
T7666 15088-15090 IN denotes of
T7665 15077-15087 NN denotes expression
T7664 15068-15076 JJ denotes aberrant
T7663 15066-15067 -COMMA- denotes ,
T7662 15059-15066 NN denotes cancers
T7661 15056-15058 IN denotes In
T7660 15053-15054 -RRB- denotes )
T7659 15052-15053 CD denotes 2
T7658 15045-15051 NN denotes Figure
T7657 15043-15044 -COLON- denotes ;
T7656 15039-15043 CD denotes 2006
T7655 15037-15038 -COMMA- denotes ,
T7654 15034-15037 FW denotes al.
T7653 15031-15033 FW denotes et
T7652 15027-15030 NNP denotes Ray
T7651 15025-15026 -COLON- denotes ;
T7650 15021-15025 CD denotes 2004
T7649 15019-15020 -COMMA- denotes ,
T7648 15016-15019 FW denotes al.
T7647 15013-15015 FW denotes et
T7646 15007-15012 NNP denotes Ghosh
T7645 15006-15007 -LRB- denotes (
T7644 14994-15005 NN denotes translation
T7643 14991-14993 IN denotes of
T7642 14985-14990 NN denotes sites
T7641 14974-14984 NN denotes initiation
T7640 14962-14973 JJ denotes alternative
T7639 14958-14961 CC denotes and
T7638 14956-14957 -COMMA- denotes ,
T7637 14947-14956 NN denotes promoters
T7636 14942-14946 NN denotes gene
T7635 14933-14941 JJ denotes multiple
T7634 14931-14932 -COMMA- denotes ,
T7633 14923-14931 NN denotes splicing
T7632 14918-14922 NN denotes mRNA
T7631 14906-14917 JJ denotes alternative
T7630 14903-14905 TO denotes to
T7629 14899-14902 JJ denotes due
T7628 14888-14898 VB denotes identified
T7627 14883-14887 VB denotes been
T7626 14878-14882 VB denotes have
T7625 14874-14877 NN denotes p53
T7624 14871-14873 IN denotes of
T7623 14862-14870 NN denotes isoforms
T7622 14857-14861 CD denotes nine
T7621 14851-14856 JJ denotes least
T7620 14848-14850 IN denotes At
T7783 15773-15776 NN denotes p21
T7782 15770-15772 IN denotes on
T7781 15761-15769 NN denotes activity
T7780 15745-15760 JJ denotes transcriptional
T7779 15741-15744 NN denotes p53
T7778 15734-15740 VB denotes affect
T7777 15730-15733 RB denotes not
T7776 15725-15729 VB denotes does
T7775 15721-15724 NN denotes p53
T7774 15716-15720 IN denotes with
T7773 15707-15715 NN denotes Δ133p53γ
T7772 15704-15706 CC denotes or
T7771 15695-15703 NN denotes Δ133p53β
T7770 15692-15694 IN denotes of
T7769 15678-15691 NN denotes Co-expression
T7768 15663-15664 -RRB- denotes e
T7767 15658-15662 CD denotes bala
T7766 15657-15658 -COMMA- denotes u
T7765 15654-15657 FW denotes (Ao
T7764 15651-15653 FW denotes rs
T7763 15644-15651 NNP denotes t manne
T7762 15643-15644 -LRB- denotes n
T7761 15636-15643 NN denotes depende
T7760 15624-15636 JJ denotes dent and -in
T7759 15621-15624 CC denotes pen
T7758 15608-15621 JJ denotes ion in p53-de
T7757 15606-15608 IN denotes ss
T7756 15596-15606 NN denotes gene expre
T7755 15591-15595 NN denotes ates
T7754 15582-15591 VB denotes lly regul
T7753 15568-15582 RB denotes 53 differentia
T7752 15561-15568 -DQE- denotes . Δ133p
T7751 15560-15561 -RRB- denotes )
T7750 15556-15560 CD denotes 2005
T7749 15554-15555 -COMMA- denotes ,
T7748 15551-15554 FW denotes al.
T7747 15548-15550 FW denotes et
T7746 15540-15547 NNP denotes Bourdon
T7745 15539-15540 -LRB- denotes (
T7744 15529-15538 NN denotes apoptosis
T6935 13235-13241 NN denotes c gene
T6934 13234-13235 -COMMA- denotes i
T6933 13230-13234 NN denotes ptot
T6932 13229-13230 -COMMA- denotes o
T6931 13226-13229 NN denotes oap
T6930 13224-13226 IN denotes pr
T6929 13219-13223 JJ denotes ting
T6928 13214-13219 NN denotes ctiva
T6927 13202-13214 JJ denotes is by transa
T6926 13187-13202 VB denotes induces apoptos
T6925 13185-13187 IN denotes 3
T6924 13176-13185 NN denotes miR34. p5
T6923 13168-13175 VB denotes icroRNA
T6922 13165-13168 NN denotes r m
T6921 13159-13165 NN denotes p21, o
T6920 13151-13159 NN denotes hibitor
T6919 13149-13151 CC denotes in
T6918 13147-13148 -COMMA- denotes e
T6917 13144-13147 NN denotes nas
T6916 13135-13144 NN denotes endent ki
T6915 13129-13135 NN denotes in-dep
T6914 13113-13129 JJ denotes nes such as cycl
T6913 13111-13113 IN denotes ge
T6912 13107-13111 JJ denotes ing
T6911 13102-13107 NN denotes tivat
T6910 13087-13102 VB denotes rest by transac
T6909 13085-13087 IN denotes ar
T6908 13079-13085 NN denotes cycle
T6907 13074-13079 NN denotes cell
T6906 13070-13074 NN denotes ces
T6905 13063-13070 VB denotes 53 indu
T6904 13060-13063 NN denotes . p
T6903 13059-13060 -RRB- denotes )
T6902 13058-13059 CD denotes 2
T6901 13051-13057 NN denotes Figure
T6900 13050-13051 -LRB- denotes (
T6899 13041-13049 VB denotes depicted
T6898 13037-13040 VB denotes are
T6897 13028-13036 NN denotes isoforms
T6896 13024-13027 PRP-DOLLAR- denotes its
T6895 13020-13023 CC denotes and
T6894 13016-13019 NN denotes p53
T6893 13013-13015 IN denotes of
T6892 13002-13012 NN denotes structures
T6891 12994-13001 JJ denotes primary
T6890 12990-12993 DT denotes The
T6889 12987-12988 -RRB- denotes )
T6888 12983-12987 CD denotes 2010
T6887 12981-12982 -COMMA- denotes ,
T6886 12975-12981 NNP denotes Levine
T6885 12971-12974 CC denotes and
T6884 12966-12970 NN denotes Lane
T6883 12965-12966 -LRB- denotes (
T6882 12954-12964 NN denotes metabolism
T6881 12951-12953 CC denotes or
T6880 12949-12950 -COMMA- denotes ,
T6879 12943-12949 NN denotes repair
T6878 12939-12942 NN denotes DNA
T6877 12937-12938 -COMMA- denotes ,
T6876 12927-12937 NN denotes senescence
T6875 12925-12926 -COMMA- denotes ,
T6874 12919-12925 NN denotes arrest
T6873 12913-12918 NN denotes cycle
T6872 12908-12912 NN denotes cell
T6871 12906-12907 -COMMA- denotes ,
T6870 12897-12906 NN denotes apoptosis
T6869 12888-12896 VB denotes mediates
T6868 12884-12887 NN denotes p53
T7026 13702-13708 NN denotes others
T7025 13697-13701 JJ denotes many
T7024 13693-13696 CC denotes and
T7023 13691-13692 -COMMA- denotes ,
T7022 13690-13691 -RRB- denotes )
T7021 13686-13690 CD denotes 1999
T7020 13684-13685 -COMMA- denotes ,
T7019 13681-13684 FW denotes al.
T7018 13678-13680 FW denotes et
T7017 13674-13677 NNP denotes Sun
T7016 13673-13674 -LRB- denotes (
T7015 13668-13672 NN denotes VIα1
T7014 13664-13667 CC denotes and
T7013 13659-13663 NN denotes IIα1
T7012 13649-13658 NN denotes collagens
T7011 13647-13648 -COMMA- denotes ,
T7010 13646-13647 -RRB- denotes )
T7009 13642-13646 CD denotes 1998
T7008 13640-13641 -COMMA- denotes ,
T7007 13637-13640 FW denotes al.
T7006 13634-13636 FW denotes et
T7005 13628-13633 NNP denotes Comer
T7004 13627-13628 -LRB- denotes (
T7003 13619-13626 NN denotes α-actin
T7002 13612-13618 NN denotes muscle
T7001 13605-13611 JJ denotes smooth
T7000 13602-13604 IN denotes of
T6999 13591-13601 NN denotes expression
T6998 13587-13590 DT denotes the
T6997 13576-13586 VB denotes regulating
T6996 13572-13575 IN denotes via
T6995 13563-13571 NN denotes motility
T6994 13558-13562 NN denotes cell
T6993 13546-13557 VB denotes controlling
T6992 13543-13545 IN denotes in
T6991 13538-13542 NN denotes role
T6990 13536-13537 DT denotes a
T6989 13530-13535 VB denotes plays
T6988 13526-13529 NN denotes p53
T6987 13524-13525 -COMMA- denotes ,
T6986 13520-13524 RB denotes Also
T6985 13457-13458 -RRB- denotes a
T6984 13453-13457 CD denotes sign
T6983 13451-13452 -COMMA- denotes s
T6982 13448-13451 FW denotes res
T6981 13446-13448 FW denotes st
T6980 13437-13445 NNP denotes y of the
T6979 13436-13437 -LRB- denotes t
T6978 13430-13436 NN denotes ntensi
T6977 13422-13430 JJ denotes s, the i
T6976 13420-13422 IN denotes pe
T6975 13414-13420 NN denotes ell ty
T6974 13411-13414 DT denotes n c
T6973 13408-13411 CC denotes upo
T6972 13406-13407 -COMMA- denotes g
T6971 13400-13406 NN denotes pendin
T6970 13394-13400 NN denotes se, de
T6969 13391-13394 DT denotes pon
T6968 13389-13391 IN denotes es
T6967 13380-13389 NN denotes l death r
T6966 13377-13380 DT denotes cel
T6965 13375-13376 -COMMA- denotes r
T6964 13370-13375 NN denotes val o
T6963 13366-13370 NN denotes urvi
T6962 13362-13366 IN denotes ro-s
T6961 13353-13362 VB denotes riggers p
T6960 13352-13353 -COMMA- denotes t
T6959 13344-13352 NN denotes 0). p53
T6958 13339-13344 NN denotes , 201
T6957 13335-13339 NN denotes vine
T6956 13333-13335 CC denotes Le
T6955 13321-13333 JJ denotes 2 (Lane and
T6954 13313-13321 VB denotes ene BCL-
T6953 13310-13313 NN denotes c g
T6952 13309-13310 -RRB- denotes i
T6951 13305-13309 CD denotes ptot
T6950 13304-13305 -COMMA- denotes o
T6949 13298-13304 NNP denotes antiap
T6948 13294-13297 CC denotes the
T6947 13290-13294 NNP denotes ing
T6946 13289-13290 -LRB- denotes t
T6945 13284-13289 NN denotes nhibi
T6944 13280-13284 NN denotes nd i
T6943 13267-13280 JJ denotes N, and FAS, a
T6942 13264-13267 DT denotes OTI
T6941 13254-13264 VB denotes , PUMA, SC
T6940 13251-13254 CC denotes BAX
T6939 13249-13250 -COMMA- denotes s
T6938 13246-13249 NN denotes h a
T6937 13243-13246 CC denotes suc
T6936 13241-13242 -COMMA- denotes s
T4990 12852-12853 -RRB- denotes )
T4989 12848-12852 CD denotes 2009
T4988 12846-12847 -COMMA- denotes ,
T4987 12843-12846 FW denotes al.
T4986 12840-12842 FW denotes et
T4985 12836-12839 NNP denotes Hsu
T4984 12835-12836 -LRB- denotes (
T4983 12826-12834 NN denotes activity
T4982 12817-12825 NN denotes promoter
T4981 12805-12816 JJ denotes SMAD-driven
T4980 12801-12804 DT denotes the
T4979 12791-12800 VB denotes enhancing
T4978 12787-12790 IN denotes for
T4977 12779-12786 NN denotes nucleus
T4976 12775-12778 DT denotes the
T4942 12589-12592 FW denotes al.
T4941 12586-12588 FW denotes et
T4940 12582-12585 NNP denotes Hsu
T4939 12581-12582 -LRB- denotes (
T4938 12574-12580 NN denotes Hyal-2
T4937 12560-12573 NN denotes hyaluronidase
T4936 12555-12559 IN denotes with
T4935 12547-12554 NN denotes binding
T4934 12543-12546 IN denotes via
T4933 12538-12542 NN denotes area
T4932 12516-12537 NN denotes membrane/cytoskeleton
T4931 12512-12515 DT denotes the
T4930 12509-12511 IN denotes in
T4929 12500-12508 VB denotes anchored
T4928 12497-12499 VB denotes is
T4927 12492-12496 NN denotes WWOX
T4926 12489-12491 IN denotes of
T4925 12481-12488 NN denotes portion
T4924 12479-12480 DT denotes A
T4923 12476-12477 -RRB- denotes )
T4922 12472-12476 CD denotes 2009
T4921 12470-12471 -COMMA- denotes ,
T4920 12467-12470 FW denotes al.
T4919 12464-12466 FW denotes et
T4918 12459-12463 NNP denotes Hong
T4917 12458-12459 -LRB- denotes (
T4916 12450-12457 NN denotes pathway
T4915 12439-12449 NN denotes activation
T4914 12428-12438 NN denotes complement
T4913 12418-12427 JJ denotes classical
T4912 12414-12417 DT denotes the
T4911 12411-12413 IN denotes of
T4910 12397-12410 RB denotes independently
T4909 12387-12396 NN denotes apoptosis
T4908 12382-12386 NN denotes cell
T4907 12379-12381 TO denotes to
T4906 12373-12378 VB denotes leads
T4905 12369-12372 CC denotes and
T4904 12363-12368 NN denotes Try33
T4903 12360-12362 IN denotes in
T4902 12344-12359 NN denotes phosphorylation
T4901 12339-12343 NN denotes WWOX
T4900 12331-12338 JJ denotes ectopic
T4899 12323-12330 VB denotes induces
T4898 12319-12322 NN denotes C1q
T4897 12308-12318 NN denotes Complement
T4896 12305-12306 -RRB- denotes )
T4895 12300-12305 NN denotes 2012a
T4894 12298-12299 -COMMA- denotes ,
T4893 12295-12298 FW denotes al.
T4892 12292-12294 FW denotes et
T4891 12286-12291 NNP denotes Zhang
T4890 12285-12286 -LRB- denotes (
T4889 12272-12284 NN denotes mitochondria
T4888 12268-12271 DT denotes the
T4887 12263-12267 IN denotes from
T4886 12253-12262 VB denotes releasing
T4885 12251-12252 NN denotes C
T4884 12240-12250 NN denotes cytochrome
T4883 12232-12239 VB denotes induces
T4882 12228-12231 CC denotes and
T4881 12217-12227 NN denotes activation
T4880 12204-12216 NN denotes procaspase-9
T4879 12200-12203 CC denotes and
T4878 12187-12199 NN denotes procaspase-3
T4877 12179-12186 VB denotes induces
T4876 12173-12178 NN denotes cells
T4875 12168-12172 NN denotes A549
T4874 12165-12167 IN denotes in
T4873 12160-12164 NN denotes WWOX
T4872 12157-12159 IN denotes of
T4871 12146-12156 NN denotes expression
T4870 12138-12145 JJ denotes Ectopic
T4869 12135-12136 -RRB- denotes )
T4868 12131-12135 CD denotes 2012
T4867 12129-12130 -COMMA- denotes ,
T4866 12126-12129 FW denotes al.
T4865 12123-12125 FW denotes et
T4864 12118-12122 NNP denotes Holt
T4863 12117-12118 -LRB- denotes (
T4862 12110-12116 NN denotes growth
T4861 12105-12109 NN denotes cell
T4860 12098-12104 NN denotes cancer
T4859 12095-12097 IN denotes of
T4858 12083-12094 NN denotes suppression
T4857 12071-12082 JJ denotes TMZ-induced
T4856 12061-12070 VB denotes increases
T4855 12052-12060 NN denotes activity
T4854 12048-12051 NN denotes MEK
T4853 12045-12047 IN denotes of
T4852 12034-12044 NN denotes Inhibition
T4851 12028-12032 NN denotes raft
T4850 12022-12027 NN denotes lipid
T4849 12018-12021 DT denotes the
T4848 12015-12017 TO denotes to
T4847 12005-12014 VB denotes relocates
T4846 12001-12004 NN denotes MEK
T4845 11993-12000 IN denotes whereas
T4844 11991-11992 -COMMA- denotes ,
T4843 11982-11991 NN denotes apoptosis
T4842 11975-11981 VB denotes induce
T4841 11972-11974 TO denotes to
T4840 11959-11971 NN denotes mitochondria
T4839 11955-11958 DT denotes the
T4838 11952-11954 TO denotes to
T4837 11940-11951 VB denotes translocate
T4836 11937-11939 TO denotes to
T4835 11932-11936 NN denotes WWOX
T4834 11924-11931 VB denotes induces
T4833 11920-11923 CC denotes and
T4832 11912-11919 NN denotes complex
T4831 11903-11911 NN denotes MEK/WWOX
T4830 11899-11902 DT denotes the
T4829 11887-11898 VB denotes dissociates
T4828 11885-11886 -RRB- denotes )
T4827 11882-11885 NN denotes PMA
T4826 11881-11882 -LRB- denotes (
T4825 11873-11880 NN denotes acetate
T4824 11863-11872 NN denotes myristate
T4823 11855-11862 NN denotes Phorbol
T4822 11852-11853 -RRB- denotes )
T4821 11848-11852 CD denotes 2011
T4820 11846-11847 -COMMA- denotes ,
T4819 11843-11846 FW denotes al.
T4818 11840-11842 FW denotes et
T4817 11836-11839 NNP denotes Lin
T4816 11835-11836 -LRB- denotes (
T4815 11829-11834 NN denotes cells
T4814 11827-11828 NN denotes T
T4813 11820-11826 NN denotes Jurkat
T4812 11817-11819 IN denotes in
T4811 11813-11816 NN denotes MEK
T4810 11807-11812 VB denotes binds
T4809 11802-11806 NN denotes WWOX
T4808 11799-11800 -RRB- denotes )
T4807 11795-11799 CD denotes 2010
T4806 11793-11794 -COMMA- denotes ,
T4805 11789-11793 CD denotes 2007
T4804 11787-11788 -COMMA- denotes ,
T4803 11784-11787 FW denotes al.
T4802 11781-11783 FW denotes et
T4801 11775-11780 NNP denotes Chang
T4800 11774-11775 -LRB- denotes (
T4799 11764-11773 NN denotes apoptosis
T4798 11755-11763 VB denotes inducing
T4797 11751-11754 IN denotes for
T4796 11744-11750 NN denotes nuclei
T4795 11741-11743 CC denotes or
T4794 11728-11740 NN denotes mitochondria
T4793 11725-11727 TO denotes to
T4792 11714-11724 VB denotes relocating
T4791 11711-11713 IN denotes by
T4790 11702-11710 VB denotes followed
T4789 11700-11701 -COMMA- denotes ,
T4788 11695-11700 NN denotes sites
T4787 11688-11694 NN denotes others
T4786 11679-11687 RB denotes probably
T4785 11675-11678 CC denotes and
T4784 11669-11674 NN denotes Tyr33
T4783 11666-11668 IN denotes in
T4782 11650-11665 NN denotes phosphorylation
T4781 11640-11649 VB denotes undergoes
T4780 11635-11639 NN denotes WWOX
T4779 11633-11634 -COMMA- denotes ,
T4778 11628-11633 NN denotes drugs
T4777 11611-11627 JJ denotes chemotherapeutic
T4776 11607-11610 CC denotes and
T4775 11595-11606 NN denotes irradiation
T4774 11592-11594 NN denotes UV
T4773 11589-11591 IN denotes as
T4772 11584-11588 JJ denotes such
T4771 11582-11583 -COMMA- denotes ,
T4770 11576-11582 NN denotes stress
T4769 11562-11575 JJ denotes environmental
T4768 11559-11561 CC denotes or
T4767 11549-11558 NN denotes chemicals
T4766 11546-11548 TO denotes to
T4765 11537-11545 NN denotes exposure
T4764 11532-11536 IN denotes Upon
T4763 11527-11530 NN denotes p53
T4762 11522-11526 IN denotes with
T4761 11506-11521 RB denotes synergistically
T4760 11500-11505 NN denotes death
T4759 11495-11499 NN denotes cell
T4758 11486-11494 VB denotes mediates
T4757 11481-11485 NN denotes WWOX
T4756 11479-11480 -COMMA- denotes ,
T4755 11475-11479 RB denotes Also
T4754 11472-11473 -RRB- denotes )
T4753 11468-11472 CD denotes 2001
T4752 11466-11467 -COMMA- denotes ,
T4751 11463-11466 FW denotes al.
T4750 11460-11462 FW denotes et
T4749 11454-11459 NNP denotes Chang
T4748 11453-11454 -LRB- denotes (
T4747 11449-11452 NN denotes p53
T4746 11439-11448 JJ denotes apoptotic
T4745 11425-11438 VB denotes up-regulating
T4744 11421-11424 CC denotes and
T4743 11414-11420 NN denotes Bcl-xL
T4742 11410-11413 CC denotes and
T4741 11404-11409 NN denotes Bcl-2
T4740 11394-11403 NN denotes inhibitor
T4739 11384-11393 NN denotes apoptosis
T4738 11368-11383 VB denotes down-regulating
T4737 11365-11367 IN denotes by
T4736 11358-11364 NN denotes factor
T4735 11349-11357 NN denotes necrosis
T4734 11343-11348 NN denotes tumor
T4733 11340-11342 IN denotes of
T4732 11331-11339 NN denotes function
T4731 11321-11330 JJ denotes cytotoxic
T4730 11317-11320 DT denotes the
T4729 11308-11316 VB denotes enhances
T4728 11303-11307 NN denotes WWOX
T4727 11300-11301 -RRB- denotes )
T4665 10984-10989 NN denotes Dvl-2
T4664 10973-10983 NN denotes sequesters
T4663 10968-10972 NN denotes WWOX
T4662 10954-10967 VB denotes overexpressed
T4661 10942-10953 NNP denotes Transiently
T4660 10937-10941 NNP denotes Dvl.
T4659 10934-10936 IN denotes in
T4658 10931-10933 VB denotes is
T4657 10925-10930 NN denotes motif
T4656 10920-10924 NN denotes PPxY
T4655 10917-10919 DT denotes No
T4654 10914-10915 -RRB- denotes )
T4653 10913-10914 CD denotes 1
T4652 10906-10912 NN denotes Figure
T4651 10905-10906 -LRB- denotes (
T4650 10897-10904 NN denotes pathway
T4649 10887-10896 NN denotes signaling
T4648 10873-10886 NN denotes Wnt/β-catenin
T4647 10870-10872 IN denotes in
T4646 10859-10869 NN denotes components
T4645 10855-10858 JJ denotes key
T4644 10851-10854 VB denotes are
T4643 10845-10850 WDT denotes which
T4642 10843-10844 -COMMA- denotes ,
T4641 10842-10843 -RRB- denotes )
T4640 10839-10842 NN denotes Dvl
T4639 10838-10839 -LRB- denotes (
T4638 10829-10837 NN denotes proteins
T4637 10818-10828 VB denotes Disheveled
T4636 10812-10817 VB denotes binds
T4635 10807-10811 NN denotes WWOX
T4634 10805-10806 -COMMA- denotes ,
T4633 10801-10805 RB denotes Also
T4632 10798-10799 -RRB- denotes )
T4631 10793-10798 NN denotes 2005b
T4630 10791-10792 -COMMA- denotes ,
T4629 10788-10791 FW denotes al.
T4628 10785-10787 FW denotes et
T4627 10779-10784 NNP denotes Chang
T4626 10778-10779 -LRB- denotes (
T4625 10769-10777 NN denotes function
T4624 10759-10768 JJ denotes apoptotic
T4623 10755-10758 PRP-DOLLAR- denotes its
T4622 10751-10754 CC denotes and
T4621 10747-10750 NN denotes p53
T4620 10736-10746 VB denotes stabilizes
T4619 10730-10735 WDT denotes which
T4618 10728-10729 -COMMA- denotes ,
T4617 10727-10728 -RRB- denotes )
T4616 10726-10727 CD denotes 1
T4615 10719-10725 NN denotes Figure
T4614 10718-10719 -LRB- denotes (
T4613 10714-10717 NN denotes p53
T4612 10696-10713 JJ denotes 46-phosphorylated
T4975 12772-12774 TO denotes to
T4974 12763-12771 VB denotes relocate
T4973 12760-12762 TO denotes to
T4972 12752-12759 NN denotes complex
T4971 12734-12751 JJ denotes WWOX/Hyal-2/Smad4
T4970 12730-12733 DT denotes the
T4969 12727-12729 IN denotes of
T4968 12717-12726 NN denotes formation
T4967 12713-12716 DT denotes the
T4966 12706-12712 VB denotes signal
T4965 12703-12705 TO denotes to
T4964 12694-12702 NN denotes receptor
T4963 12686-12693 JJ denotes cognate
T4962 12684-12685 DT denotes a
T4961 12681-12683 IN denotes as
T4960 12674-12680 NN denotes Hyal-2
T4959 12668-12673 VB denotes binds
T4958 12665-12667 NN denotes β1
T4957 12658-12664 NN denotes factor
T4956 12651-12657 NN denotes growth
T4955 12638-12650 VB denotes Transforming
T4954 12635-12636 -RRB- denotes )
T4953 12631-12635 CD denotes 2006
T4952 12629-12630 -COMMA- denotes ,
T4951 12626-12629 FW denotes al.
T4950 12623-12625 FW denotes et
T4949 12619-12622 NNP denotes Jin
T4948 12618-12619 -LRB- denotes (
T4947 12604-12617 NN denotes Phospho-Ezrin
T4946 12600-12603 CC denotes and
T4945 12598-12599 -RRB- denotes )
T4944 12594-12598 CD denotes 2009
T4943 12592-12593 -COMMA- denotes ,
T4611 10689-10695 NN denotes serine
T4610 10684-10688 IN denotes with
T4609 10674-10683 VB denotes interacts
T4608 10663-10673 RB denotes physically
T4607 10658-10662 NN denotes WWOX
T4606 10648-10657 VB denotes Activated
T4605 10645-10646 -RRB- denotes )
T4604 10641-10645 CD denotes 2010
T4603 10639-10640 -COMMA- denotes ,
T4602 10635-10639 CD denotes 2007
T4601 10633-10634 -COMMA- denotes ,
T4600 10632-10633 NN denotes b
T4599 10631-10632 -COMMA- denotes ,
T4598 10626-10631 NN denotes 2005a
T4597 10624-10625 -COMMA- denotes ,
T4596 10620-10624 CD denotes 2003
T4595 10618-10619 -COMMA- denotes ,
T4594 10614-10618 CD denotes 2001
T4593 10612-10613 -COMMA- denotes ,
T4592 10609-10612 FW denotes al.
T4591 10606-10608 FW denotes et
T4590 10600-10605 NNP denotes Chang
T4589 10599-10600 -LRB- denotes (
T4588 10593-10598 NN denotes motif
T4587 10588-10592 NN denotes PPxY
T4586 10584-10587 DT denotes the
T4585 10581-10583 IN denotes of
T4584 10567-10580 RB denotes independently
T4583 10558-10566 NN denotes proteins
T4582 10552-10557 VB denotes binds
T4581 10548-10551 CC denotes and
T4580 10546-10547 -COMMA- denotes ,
T4579 10541-10546 NN denotes Tyr33
T4578 10538-10540 IN denotes at
T4577 10522-10537 NN denotes phosphorylation
T4576 10518-10521 IN denotes via
T4575 10508-10517 VB denotes activated
T4574 10505-10507 VB denotes is
T4573 10500-10504 NN denotes WWOX
T4572 10498-10499 -COMMA- denotes ,
T4571 10488-10498 NN denotes conditions
T4570 10481-10487 NN denotes stress
T4569 10475-10480 IN denotes Under
T4568 10465-10473 VB denotes observed
T4567 10461-10464 VB denotes was
T4566 10456-10460 NN denotes Wwox
T4565 10453-10455 IN denotes by
T4564 10446-10452 NN denotes nuclei
T4563 10442-10445 DT denotes the
T4562 10439-10441 TO denotes to
T4561 10431-10438 NN denotes factors
T4560 10417-10430 NN denotes transcription
T4559 10414-10416 IN denotes of
T4558 10400-10413 NN denotes translocation
T4557 10397-10399 IN denotes of
T4556 10388-10396 NN denotes blocking
T4555 10385-10387 DT denotes No
T4554 10382-10383 -RRB- denotes )
T4553 10378-10382 CD denotes 2009
T4552 10376-10377 -COMMA- denotes ,
T4551 10373-10376 FW denotes al.
T4550 10370-10372 FW denotes et
T4549 10367-10369 NNP denotes Li
T4548 10366-10367 -LRB- denotes (
T4547 10361-10365 NN denotes rats
T4546 10358-10360 IN denotes in
T4545 10350-10357 NN denotes axotomy
T4544 10344-10349 NN denotes nerve
T4543 10336-10343 JJ denotes sciatic
T4542 10331-10335 IN denotes upon
T4541 10323-10330 NN denotes neurons
T4540 10320-10322 IN denotes of
T4539 10313-10319 NN denotes nuclei
T4538 10309-10312 DT denotes the
T4537 10306-10308 TO denotes to
T4536 10298-10305 NN denotes factors
T4535 10284-10297 NN denotes transcription
T4534 10271-10283 JJ denotes pro-survival
T4533 10267-10270 CC denotes and
T4532 10254-10266 JJ denotes proapoptotic
T4531 10249-10253 IN denotes with
T4530 10237-10248 NN denotes co-migrates
T4529 10232-10236 NNP denotes Wwox
T4528 10230-10231 -COMMA- denotes ,
T4527 10222-10230 NN denotes contrast
T4526 10216-10221 JJ denotes stark
T4525 10213-10215 IN denotes In
T4524 10210-10211 -RRB- denotes )
T4523 10206-10210 CD denotes 2012
T4522 10204-10205 -COMMA- denotes ,
T4521 10201-10204 FW denotes al.
T4520 10198-10200 FW denotes et
T4519 10192-10197 NNP denotes Salah
T4518 10191-10192 -LRB- denotes (
T4517 10182-10190 NN denotes survival
T4516 10177-10181 NN denotes cell
T4515 10170-10176 NN denotes cancer
T4514 10159-10169 VB denotes suppresses
T4513 10153-10158 WDT denotes which
T4512 10151-10152 -COMMA- denotes ,
T4511 10146-10151 FW denotes vitro
T4510 10143-10145 FW denotes in
T4509 10132-10142 NN denotes relocation
T4508 10124-10131 JJ denotes nuclear
T4507 10118-10123 PRP-DOLLAR- denotes their
T4506 10112-10117 VB denotes block
T4505 10108-10111 CC denotes and
T4504 10102-10107 NN denotes c-Jun
T4503 10098-10101 CC denotes and
T4502 10096-10097 -COMMA- denotes ,
T4501 10093-10096 NN denotes p73
T4500 10091-10092 -COMMA- denotes ,
T4499 10087-10091 NN denotes AP-2
T4498 10079-10086 NN denotes factors
T4497 10065-10078 NN denotes transcription
T4496 10059-10064 VB denotes binds
T4495 10054-10058 NN denotes WWOX
T4494 10040-10053 VB denotes overexpressed
T4493 10028-10039 RB denotes Transiently
T4492 10025-10026 -RRB- denotes )
T4491 10024-10025 CD denotes 1
T4490 10017-10023 NN denotes Figure
T4489 10015-10016 -COLON- denotes ;
T4488 10011-10015 CD denotes 2012
T4487 10009-10010 -COMMA- denotes ,
T4486 10006-10009 FW denotes al.
T4485 10003-10005 FW denotes et
T4484 10000-10002 NNP denotes Su
T4483 9998-9999 -COLON- denotes ;
T4482 9994-9998 CD denotes 2012
T4481 9992-9993 -COMMA- denotes ,
T4480 9989-9992 FW denotes al.
T4479 9986-9988 FW denotes et
T4478 9980-9985 NNP denotes Salah
T4477 9978-9979 -COLON- denotes ;
T4476 9974-9978 CD denotes 2007
T4475 9972-9973 -COMMA- denotes ,
T4474 9969-9972 FW denotes al.
T4473 9966-9968 FW denotes et
T4472 9960-9965 NNP denotes Chang
T4471 9959-9960 -LRB- denotes (
T4470 9952-9958 NN denotes others
T4469 9947-9951 JJ denotes many
T4468 9943-9946 CC denotes and
T4467 9941-9942 -COMMA- denotes ,
T4466 9936-9941 NN denotes RUNX4
T4465 9934-9935 -COMMA- denotes ,
T4464 9929-9934 NN denotes c-Jun
T4463 9927-9928 -COMMA- denotes ,
T4462 9921-9927 NN denotes SIMPLE
T4461 9919-9920 -COMMA- denotes ,
T4460 9914-9919 NN denotes Ezrin
T4459 9912-9913 -COMMA- denotes ,
T4458 9907-9912 NN denotes ErbB4
T4457 9905-9906 -COMMA- denotes ,
T4456 9902-9905 NN denotes p73
T4455 9900-9901 -COMMA- denotes ,
T4454 9895-9900 NN denotes AP-2γ
T4453 9892-9894 IN denotes as
T4452 9887-9891 JJ denotes such
T4451 9885-9886 -RRB- denotes )
T4450 9884-9885 NN denotes s
T4335 9371-9373 FW denotes et
T4334 9364-9370 NNP denotes Donati
T4333 9363-9364 -LRB- denotes (
T4332 9353-9362 NN denotes carcinoma
T4331 9348-9352 NN denotes lung
T4330 9343-9347 NN denotes cell
T4329 9333-9342 JJ denotes non-small
T4328 9330-9332 IN denotes as
T4327 9325-9329 JJ denotes such
T4326 9323-9324 -COMMA- denotes ,
T4325 9316-9323 NN denotes cancers
T4324 9306-9315 JJ denotes malignant
T4323 9297-9305 JJ denotes multiple
T4322 9294-9296 IN denotes in
T4321 9281-9293 NN denotes modification
T4320 9270-9280 JJ denotes epigenetic
T4319 9265-9269 IN denotes from
T4318 9260-9264 VB denotes lost
T4317 9257-9259 CC denotes or
T4316 9249-9256 VB denotes altered
T4315 9242-9248 CC denotes either
T4314 9239-9241 VB denotes is
T4313 9234-9238 NN denotes WWOX
T4312 9231-9233 IN denotes of
T4311 9220-9230 NN denotes Expression
T4310 7498-7499 -RRB- denotes )
T4309 7494-7498 CD denotes 2012
T4308 7492-7493 -COMMA- denotes ,
T4307 7489-7492 FW denotes al.
T4306 7486-7488 FW denotes et
T4305 7483-7485 NNP denotes Su
T4304 7481-7482 -COLON- denotes ;
T4303 7476-7481 NN denotes 2005a
T4302 7474-7475 -COMMA- denotes ,
T4301 7471-7474 FW denotes al.
T4300 7468-7470 FW denotes et
T4299 7462-7467 NNP denotes Chang
T4298 7461-7462 -LRB- denotes (
T4297 7452-7460 NN denotes estrogen
T4296 7448-7451 CC denotes and
T4295 7439-7447 NN denotes androgen
T4294 7434-7438 IN denotes with
T4293 7422-7433 VB denotes interacting
T4292 7419-7421 IN denotes of
T4291 7411-7418 JJ denotes capable
T4290 7405-7410 NN denotes motif
T4289 7400-7404 NN denotes NSYK
T4288 7397-7399 DT denotes an
T4287 7387-7396 VB denotes possesses
T4286 7380-7386 NN denotes domain
T4285 7376-7379 NN denotes SDR
T4284 7372-7375 PRP-DOLLAR- denotes its
T4283 7366-7371 IN denotes since
T4282 7364-7365 -COMMA- denotes ,
T4726 11296-11300 CD denotes 2012
T4725 11294-11295 -COMMA- denotes ,
T4724 11291-11294 FW denotes al.
T4723 11288-11290 FW denotes et
T4722 11285-11287 NNP denotes Su
T4721 11283-11284 -COLON- denotes ;
T4720 11279-11283 CD denotes 2012
T4719 11277-11278 -COMMA- denotes ,
T4718 11274-11277 FW denotes al.
T4717 11271-11273 FW denotes et
T4716 11265-11270 NNP denotes Salah
T4715 11263-11264 -COLON- denotes ;
T4714 11259-11263 CD denotes 2010
T4713 11257-11258 -COMMA- denotes ,
T4712 11253-11257 CD denotes 2007
T4711 11251-11252 -COMMA- denotes ,
T4710 11248-11251 FW denotes al.
T4709 11245-11247 FW denotes et
T4708 11239-11244 NNP denotes Chang
T4707 11238-11239 -LRB- denotes (
T4706 11232-11237 NN denotes types
T4705 11227-11231 NN denotes cell
T4704 11220-11226 NN denotes cancer
T4703 11215-11219 JJ denotes many
T4702 11211-11214 CC denotes and
T4701 11209-11210 -RRB- denotes )
T4700 11205-11209 CD denotes 2012
T4699 11203-11204 -COMMA- denotes ,
T4698 11200-11203 FW denotes al.
T4697 11197-11199 FW denotes et
T4696 11194-11196 NNP denotes Hu
T4695 11193-11194 -LRB- denotes (
T4694 11187-11192 NN denotes cells
T4693 11177-11186 NN denotes carcinoma
T4692 11169-11176 JJ denotes hepatic
T4691 11163-11168 JJ denotes human
T4690 11160-11162 IN denotes of
T4689 11146-11159 NN denotes proliferation
T4688 11137-11145 VB denotes inhibits
T4687 11133-11136 CC denotes and
T4686 11123-11132 NN denotes apoptosis
T4685 11115-11122 VB denotes induces
T4684 11110-11114 NN denotes WWOX
T4683 11096-11109 VB denotes Overexpressed
T4682 11093-11094 -RRB- denotes )
T4681 11089-11093 CD denotes 2009
T4680 11087-11088 -COMMA- denotes ,
T4679 11084-11087 FW denotes al.
T4678 11081-11083 FW denotes et
T4677 11071-11080 NNP denotes Bouteille
T4676 11070-11071 -LRB- denotes (
T4675 11061-11069 NN denotes activity
T4674 11045-11060 JJ denotes transcriptional
T4673 11041-11044 NN denotes TCF
T4672 11026-11040 JJ denotes Dvl-2-mediated
T4671 11019-11025 VB denotes blocks
T4670 11011-11018 RB denotes thereby
T4669 11007-11010 CC denotes and
T4668 10997-11006 NN denotes cytoplasm
T4667 10993-10996 DT denotes the
T4666 10990-10992 IN denotes in
T4281 7356-7364 NN denotes hormones
T4280 7348-7355 NN denotes steroid
T4279 7344-7347 NN denotes sex
T4278 7340-7343 IN denotes for
T4277 7331-7339 NN denotes receptor
T4276 7319-7330 JJ denotes alternative
T4275 7316-7318 DT denotes an
T4274 7313-7315 IN denotes as
T4273 7309-7312 VB denotes act
T4272 7305-7308 MD denotes may
T4271 7300-7304 NN denotes WWOX
T4270 7297-7298 -RRB- denotes )
T4269 7296-7297 CD denotes 1
T4268 7289-7295 NN denotes Figure
T4267 7288-7289 -LRB- denotes (
T4266 7286-7287 -RRB- denotes )
T4265 7282-7286 CD denotes 2012
T4264 7280-7281 -COMMA- denotes ,
T4263 7277-7280 FW denotes al.
T4262 7274-7276 FW denotes et
T4261 7268-7273 NNP denotes Salah
T4260 7266-7267 -COLON- denotes ;
T4259 7262-7266 CD denotes 2007
T4258 7260-7261 -COMMA- denotes ,
T4257 7257-7260 FW denotes al.
T4256 7254-7256 FW denotes et
T4255 7249-7253 NNP denotes Hong
T4254 7247-7248 -COLON- denotes ;
T4253 7243-7247 CD denotes 2007
T4252 7241-7242 -COMMA- denotes ,
T4251 7237-7241 CD denotes 2004
T4250 7235-7236 -COMMA- denotes ,
T4249 7232-7235 FW denotes al.
T4248 7229-7231 FW denotes et
T4247 7221-7228 NNP denotes Aqeilan
T4246 7219-7220 -COLON- denotes ;
T4245 7215-7219 CD denotes 2010
T4244 7213-7214 -COMMA- denotes ,
T4243 7209-7213 CD denotes 2007
T4242 7207-7208 -COMMA- denotes ,
T4241 7203-7207 CD denotes 2001
T4240 7201-7202 -COMMA- denotes ,
T4239 7198-7201 FW denotes al.
T4238 7195-7197 FW denotes et
T4237 7189-7194 NNP denotes Chang
T4236 7188-7189 -LRB- denotes (
T4235 7185-7187 NN denotes D3
T4234 7180-7184 NN denotes tail
T4233 7169-7179 JJ denotes C-terminal
T4232 7156-7168 JJ denotes proapoptotic
T4231 7154-7155 DT denotes a
T4230 7150-7153 CC denotes and
T4229 7148-7149 -COMMA- denotes ,
T4228 7142-7148 NN denotes domain
T4227 7140-7141 -RRB- denotes )
T4226 7137-7140 NN denotes SDR
T4225 7136-7137 -LRB- denotes (
T4224 7112-7135 NN denotes dehydrogenase/reductase
T4223 7104-7111 NN denotes alcohol
T4222 7092-7103 NN denotes short-chain
T4221 7081-7091 JJ denotes C-terminal
T4220 7079-7080 DT denotes a
T4219 7077-7078 -COMMA- denotes ,
T4218 7070-7077 NN denotes domains
T4217 7067-7069 NN denotes WW
T4216 7056-7066 JJ denotes N-terminal
T4215 7052-7055 CD denotes two
T4214 7049-7051 IN denotes of
T4213 7040-7048 VB denotes composed
T4212 7037-7039 VB denotes is
T4211 7029-7036 NN denotes protein
T4210 7024-7028 NN denotes WWOX
T4209 7012-7023 JJ denotes full-length
T4208 7008-7011 DT denotes The
T4207 7000-7006 NN denotes FRA16D
T4206 6995-6999 NN denotes site
T4205 6987-6994 JJ denotes fragile
T4204 6980-6986 JJ denotes common
T4203 6976-6979 DT denotes the
T4202 6973-6975 IN denotes as
T4201 6967-6972 VB denotes known
T4200 6962-6966 NN denotes area
T4199 6959-6961 DT denotes an
T4198 6957-6958 -COMMA- denotes ,
T4197 6945-6957 NN denotes 16q23.3–24.1
T4196 6934-6944 NN denotes chromosome
T4195 6931-6933 IN denotes in
T4194 6923-6930 JJ denotes located
T4193 6920-6922 VB denotes is
T4192 6915-6919 NN denotes gene
T4191 6910-6914 DT denotes This
T4190 6904-6908 NN denotes gene
T4189 6894-6903 NN denotes WWOX/Wwox
T4188 6888-6893 NN denotes mouse
T4187 6885-6887 CC denotes or
T4186 6879-6884 JJ denotes human
T4185 6876-6878 IN denotes by
T4184 6868-6875 VB denotes encoded
T4183 6865-6867 VB denotes is
T4182 6863-6864 -COMMA- denotes ,
T4181 6859-6863 NN denotes WOX1
T4180 6856-6858 CC denotes or
T4179 6854-6855 -COMMA- denotes ,
T4178 6851-6854 NN denotes FOR
T4177 6849-6850 -COMMA- denotes ,
T4176 6845-6849 NN denotes WWOX
T4175 6842-6844 IN denotes as
T4174 6836-6841 VB denotes known
T4173 6834-6835 -COMMA- denotes ,
T4172 6820-6834 NN denotes oxidoreductase
T4171 6802-6819 JJ denotes domain-containing
T4170 6799-6801 JJ denotes WW
T4169 6796-6797 -RRB- denotes )
T4168 6792-6796 CD denotes 2012
T4167 6790-6791 -COMMA- denotes ,
T4166 6787-6790 FW denotes al.
T4165 6784-6786 FW denotes et
T4164 6777-6783 NNP denotes Chiang
T4163 6776-6777 -LRB- denotes (
T4162 6770-6775 NN denotes cells
T4161 6757-6769 NN denotes glioblastoma
T4160 6754-6756 IN denotes of
T4159 6744-6753 NN denotes apoptosis
T4158 6740-6743 DT denotes the
T4157 6731-6739 VB denotes regulate
T4156 6728-6730 TO denotes to
T4155 6722-6727 VB denotes shown
T4154 6717-6721 VB denotes were
T4153 6712-6716 NN denotes WWOX
T4152 6708-6711 CC denotes and
T4151 6704-6707 NN denotes p53
T4150 6692-6703 NN denotes suppressors
T4149 6686-6691 NN denotes tumor
T4148 6684-6685 -COMMA- denotes ,
T4147 6676-6684 RB denotes Recently
T4449 9883-9884 -LRB- denotes (
T4448 9878-9883 NN denotes motif
T4447 9873-9877 NN denotes PPxY
T4446 9871-9872 DT denotes a
T4445 9860-9870 VB denotes possessing
T4444 9851-9859 NN denotes proteins
T4443 9846-9850 IN denotes with
T4442 9837-9845 VB denotes interact
T4441 9833-9836 MD denotes may
T4440 9828-9832 NN denotes WWOX
T4439 9825-9827 IN denotes of
T4438 9818-9824 NN denotes domain
T4437 9815-9817 NN denotes WW
T4436 9809-9814 JJ denotes first
T4435 9805-9808 DT denotes The
T4434 9802-9803 -RRB- denotes )
T4433 9798-9802 CD denotes 2009
T4432 9796-9797 -COMMA- denotes ,
T4431 9793-9796 FW denotes al.
T4430 9790-9792 FW denotes et
T4429 9785-9789 NNP denotes Hong
T4428 9784-9785 -LRB- denotes (
T4427 9777-9783 NN denotes cancer
T4426 9768-9776 NN denotes prostate
T4425 9764-9767 CC denotes and
T4424 9762-9763 -COMMA- denotes ,
T4423 9761-9762 -RRB- denotes )
T4422 9757-9761 CD denotes 2008
T4421 9755-9756 -COMMA- denotes ,
T4420 9752-9755 FW denotes al.
T4419 9749-9751 FW denotes et
T4418 9740-9748 NNP denotes Nakayama
T4417 9739-9740 -LRB- denotes (
T4416 9732-9738 NN denotes cancer
T4415 9721-9731 JJ denotes pancreatic
T4414 9719-9720 -COMMA- denotes ,
T4413 9718-9719 -RRB- denotes )
T4412 9714-9718 CD denotes 2005
T4411 9712-9713 -COMMA- denotes ,
T4410 9709-9712 FW denotes al.
T4409 9706-9708 FW denotes et
T4408 9699-9705 NNP denotes Fabbri
T4407 9698-9699 -LRB- denotes (
T4406 9691-9697 NN denotes cancer
T4405 9686-9690 NN denotes lung
T4404 9683-9685 IN denotes of
T4403 9676-9682 NN denotes growth
T4402 9672-9675 DT denotes the
T4401 9663-9671 VB denotes prevents
T4400 9658-9662 NN denotes gene
T4399 9653-9657 NN denotes WWOX
T4398 9650-9652 IN denotes of
T4397 9638-9649 NN denotes Restoration
T4396 9635-9636 -RRB- denotes )
T4395 9631-9635 CD denotes 2011
T4394 9629-9630 -COMMA- denotes ,
T4393 9626-9629 FW denotes al.
T4392 9623-9625 FW denotes et
T4391 9617-9622 NNP denotes Kosla
T4390 9616-9617 -LRB- denotes (
T4389 9605-9615 JJ denotes multiforme
T4388 9592-9604 NN denotes glioblastoma
T4387 9588-9591 CC denotes and
T4386 9586-9587 -COMMA- denotes ,
T4385 9585-9586 -RRB- denotes )
T4384 9581-9585 CD denotes 2007
T4383 9579-9580 -COMMA- denotes ,
T4382 9576-9579 FW denotes al.
T4381 9573-9575 FW denotes et
T4380 9565-9572 NNP denotes Aqeilan
T4379 9563-9564 -COLON- denotes ;
T4378 9559-9563 CD denotes 2004
T4377 9557-9558 -COMMA- denotes ,
T4376 9554-9557 FW denotes al.
T4375 9551-9553 FW denotes et
T4374 9545-9550 NNP denotes Guler
T4373 9544-9545 -LRB- denotes (
T4372 9534-9543 NN denotes carcinoma
T4371 9527-9533 NN denotes breast
T4370 9525-9526 -COMMA- denotes ,
T4369 9524-9525 -RRB- denotes )
T4368 9520-9524 CD denotes 2004
T4367 9518-9519 -COMMA- denotes ,
T4366 9515-9518 FW denotes al.
T4365 9512-9514 FW denotes et
T4364 9505-9511 NNP denotes Kuroki
T4363 9504-9505 -LRB- denotes (
T4362 9494-9503 NN denotes carcinoma
T4361 9483-9493 JJ denotes pancreatic
T4360 9481-9482 -COMMA- denotes ,
T4359 9480-9481 -RRB- denotes )
T4358 9476-9480 CD denotes 2004
T4357 9474-9475 -COMMA- denotes ,
T4356 9471-9474 FW denotes al.
T4355 9468-9470 FW denotes et
T4354 9460-9467 NNP denotes Aqeilan
T4353 9459-9460 -LRB- denotes (
T4352 9449-9458 NN denotes carcinoma
T4351 9441-9448 JJ denotes gastric
T4350 9439-9440 -COMMA- denotes ,
T4349 9438-9439 -RRB- denotes )
T4348 9434-9438 CD denotes 2004
T4347 9432-9433 -COMMA- denotes ,
T4346 9424-9432 NNP denotes Furukawa
T4345 9420-9423 CC denotes and
T4344 9414-9419 NNP denotes Ishii
T4343 9413-9414 -LRB- denotes (
T4342 9400-9412 NN denotes malignancies
T4341 9386-9399 JJ denotes hematopoietic
T4340 9384-9385 -COMMA- denotes ,
T4339 9383-9384 -RRB- denotes )
T4338 9379-9383 CD denotes 2007
T4337 9377-9378 -COMMA- denotes ,
T4336 9374-9377 FW denotes al.
T1896 6621-6632 VB denotes established
T1895 6618-6620 VB denotes be
T1894 6615-6617 TO denotes to
T1893 6611-6614 RB denotes yet
T1892 6607-6610 VB denotes has
T1891 6598-6606 NN denotes function
T1890 6587-6597 JJ denotes biological
T1889 6583-6586 PRP-DOLLAR- denotes its
T1888 6580-6582 TO denotes to
T1887 6571-6579 JJ denotes relative
T1886 6565-6570 NN denotes cells
T1885 6560-6564 NN denotes stem
T1884 6553-6559 NN denotes cancer
T1883 6546-6552 NN denotes glioma
T1882 6542-6545 IN denotes for
T1881 6535-6541 NN denotes marker
T1880 6533-6534 DT denotes a
T1879 6530-6532 IN denotes as
T1878 6524-6529 NN denotes CD133
T1877 6521-6523 IN denotes of
T1876 6516-6520 NN denotes role
T1875 6512-6515 DT denotes the
T1874 6510-6511 -COMMA- denotes ,
T1873 6503-6510 RB denotes However
T1872 6500-6501 -RRB- denotes )
T1871 6496-6500 CD denotes 2012
T1870 6494-6495 -COMMA- denotes ,
T1869 6484-6494 NNP denotes Pilkington
T1868 6480-6483 CC denotes and
T1867 6472-6479 NNP denotes Donovan
T1866 6471-6472 -LRB- denotes (
T1865 6465-6470 NN denotes cells
T1864 6460-6464 NN denotes stem
T1863 6453-6459 NN denotes cancer
T1862 6449-6452 CC denotes and
T1861 6443-6448 NN denotes cells
T1860 6438-6442 NN denotes stem
T1859 6431-6437 JJ denotes normal
T1858 6426-6430 CC denotes both
T1857 6423-6425 IN denotes in
T1856 6413-6422 VB denotes expressed
T1855 6409-6412 VB denotes are
T1854 6403-6408 NN denotes cells
T1853 6398-6402 NN denotes stem
T1852 6391-6397 NN denotes cancer
T1851 6376-6390 JJ denotes CD133-positive
T1850 6373-6374 -RRB- denotes )
T1849 6369-6373 CD denotes 2012
T1848 6367-6368 -COMMA- denotes ,
T1847 6364-6367 FW denotes al.
T1846 6361-6363 FW denotes et
T1845 6356-6360 NNP denotes Chen
T1844 6354-6355 -COLON- denotes ;
T1843 6350-6354 CD denotes 2011
T1842 6348-6349 -COMMA- denotes ,
T1841 6345-6348 FW denotes al.
T1840 6342-6344 FW denotes et
T1839 6336-6341 NNP denotes Beier
T1838 6335-6336 -LRB- denotes (
T1837 6327-6334 VB denotes thought
T1836 6316-6326 RB denotes previously
T1835 6311-6315 IN denotes than
T1834 6299-6310 VB denotes complicated
T1833 6294-6298 RB denotes more
T1832 6289-6293 VB denotes been
T1831 6285-6288 VB denotes has
T1830 6279-6284 NN denotes drugs
T1829 6262-6278 JJ denotes chemotherapeutic
T1828 6256-6261 JJ denotes other
T1827 6252-6255 CC denotes and
T1826 6248-6251 NN denotes TMZ
T1825 6243-6247 IN denotes with
T1824 6233-6242 NN denotes treatment
T1823 6228-6232 IN denotes from
T1822 6219-6227 NN denotes survival
T1821 6214-6218 NN denotes cell
T1820 6209-6213 NN denotes stem
T1819 6202-6208 NN denotes cancer
T1818 6199-6201 IN denotes of
T1817 6191-6198 NN denotes concept
T1816 6187-6190 DT denotes The
T1815 6176-6185 NN denotes treatment
T1814 6172-6175 NN denotes TMZ
T1813 6169-6171 IN denotes in
T1812 6161-6168 NN denotes failure
T1811 6158-6160 TO denotes to
T1810 6154-6157 NN denotes key
T1809 6150-6153 DT denotes the
T1808 6141-6149 RB denotes probably
T1807 6137-6140 VB denotes are
T1806 6131-6136 NN denotes cells
T1805 6126-6130 NN denotes stem
T1804 6119-6125 NN denotes Cancer
T1803 6116-6117 -RRB- denotes )
T1802 6112-6116 CD denotes 2012
T1801 6110-6111 -COMMA- denotes ,
T1800 6107-6110 FW denotes al.
T1799 6104-6106 FW denotes et
T1798 6100-6103 NNP denotes Sun
T1797 6099-6100 -LRB- denotes (
T1796 6094-6098 NN denotes GBMs
T1795 6091-6093 IN denotes in
T1794 6080-6090 NN denotes resistance
T1793 6076-6079 NN denotes TMZ
T1792 6068-6075 VB denotes reverse
T1791 6065-6067 TO denotes to
T1790 6056-6064 VB denotes utilized
T1789 6053-6055 VB denotes be
T1788 6049-6052 MD denotes can
T1787 6039-6048 NN denotes hyperoxia
T1786 6031-6038 VB denotes Induced
T1785 6019-6029 NN denotes resistance
T1784 6015-6018 NN denotes TMZ
T1783 6012-6014 IN denotes of
T1782 6000-6011 NN denotes development
T1781 5996-5999 DT denotes the
T1780 5991-5995 IN denotes with
T1779 5980-5990 VB denotes associated
T1778 5977-5979 VB denotes be
T1777 5973-5976 MD denotes may
T1776 5969-5972 CC denotes and
T1775 5964-5968 NN denotes GBMs
T1774 5961-5963 IN denotes in
T1773 5954-5960 JJ denotes common
T1772 5951-5953 VB denotes is
T1771 5943-5950 NN denotes hypoxia
T1770 5930-5942 JJ denotes Intratumoral
T1769 5927-5928 -RRB- denotes )
T1768 5923-5927 CD denotes 2012
T1767 5921-5922 -COMMA- denotes ,
T1766 5918-5921 FW denotes al.
T1765 5915-5917 FW denotes et
T1764 5907-5914 NNP denotes Kohsaka
T1763 5906-5907 -LRB- denotes (
T1762 5900-5905 NN denotes lines
T1761 5895-5899 NN denotes cell
T1760 5891-5894 NN denotes GBM
T1759 5881-5890 JJ denotes resistant
T1758 5878-5880 IN denotes in
T1757 5869-5877 NN denotes efficacy
T1756 5865-5868 NN denotes TMZ
T1755 5853-5864 VB denotes potentiates
T1754 5843-5852 NN denotes knockdown
T1753 5837-5842 NN denotes STAT3
T1752 5834-5836 CC denotes or
T1751 5824-5833 NN denotes inhibitor
T1750 5818-5823 NN denotes STAT3
T1749 5815-5816 -RRB- denotes )
T1748 5811-5815 CD denotes 2012
T1747 5809-5810 -COMMA- denotes ,
T1746 5806-5809 FW denotes al.
T1745 5803-5805 FW denotes et
T1744 5797-5802 NNP denotes Huang
T1743 5796-5797 -LRB- denotes (
T1742 5786-5795 NN denotes mechanism
T1741 5770-5785 JJ denotes NF-κB-dependent
T1740 5767-5769 DT denotes an
T1739 5763-5766 IN denotes via
T1738 5752-5762 NN denotes resistance
T1737 5748-5751 NN denotes TMZ
T1736 5739-5747 VB denotes reverses
T1735 5737-5738 -COMMA- denotes ,
T1734 5727-5737 NN denotes polyphenol
T1733 5719-5726 JJ denotes natural
T1732 5717-5718 DT denotes a
T1731 5715-5716 -COMMA- denotes ,
T1730 5704-5715 NN denotes Resveratrol
T1729 5701-5702 -RRB- denotes )
T1728 5697-5701 CD denotes 2012
T1727 5695-5696 -COMMA- denotes ,
T1726 5692-5695 FW denotes al.
T1725 5689-5691 FW denotes et
T1724 5682-5688 NNP denotes Nakada
T1723 5681-5682 -LRB- denotes (
T1722 5670-5680 NN denotes mechanisms
T1721 5657-5669 JJ denotes -independent
T1720 5654-5656 CC denotes or
T1719 5639-5653 JJ denotes MGMT-dependent
T1718 5631-5638 IN denotes through
T1717 5627-5630 NN denotes TMZ
T1716 5624-5626 IN denotes of
T1715 5612-5623 NN denotes sensitivity
T1714 5608-5611 DT denotes the
T1713 5599-5607 VB denotes increase
T1712 5597-5598 -RRB- denotes )
T1711 5594-5597 NN denotes VAP
T1710 5593-5594 -LRB- denotes (
T1709 5588-5592 NN denotes acid
T1708 5579-5587 JJ denotes valproic
T1707 5575-5578 CC denotes and
T1706 5573-5574 -COMMA- denotes ,
T1705 5562-5573 NN denotes resveratrol
T1704 5560-5561 -COMMA- denotes ,
T1703 5559-5560 -RRB- denotes )
T1702 5556-5559 NN denotes LEV
T1701 5555-5556 -LRB- denotes (
T1700 5541-5554 NN denotes levetiracetam
T1699 5539-5540 -COMMA- denotes ,
T1698 5538-5539 -RRB- denotes )
T1554 4674-4690 NN denotes N3-methyladenine
T1553 4666-4673 NN denotes lesions
T1552 4656-4665 JJ denotes cytotoxic
T1551 4652-4655 DT denotes the
T1550 4644-4651 VB denotes repairs
T1549 4638-4643 WDT denotes which
T1548 4636-4637 -COMMA- denotes ,
T1547 4635-4636 -RRB- denotes )
T1546 4631-4635 NN denotes APNG
T1545 4630-4631 -LRB- denotes (
T1544 4600-4629 NN denotes alkylpurine-DNA-N-glycosylase
T1543 4593-4599 NN denotes enzyme
T1542 4586-4592 NN denotes repair
T1541 4577-4585 NN denotes excision
T1540 4572-4576 NN denotes base
T1539 4568-4571 DT denotes The
T1538 4548-4554 NN denotes grade
T1537 4543-4548 NN denotes high-
T1536 4532-4542 JJ denotes target for
T1535 4529-4532 IN denotes ic
T1534 4523-4529 NN denotes rapeut
T1533 4512-4523 JJ denotes ed as a the
T1532 4511-4512 DT denotes r
T1531 4509-4511 IN denotes de
T1530 4499-4509 VB denotes n is consi
T1529 4497-4499 VB denotes ri
T1528 4489-4497 NN denotes β1 integ
T1527 4485-4489 CD denotes . α5
T1526 4484-4485 -RRB- denotes )
T1525 4480-4484 CD denotes 2012
T1524 4478-4479 -COMMA- denotes ,
T1523 4475-4478 FW denotes al.
T1522 4472-4474 FW denotes et
T1521 4461-4471 NNP denotes Janouskova
T1520 4460-4461 -LRB- denotes (
T1519 4456-4459 NN denotes TMZ
T1518 4453-4455 TO denotes to
T1517 4442-4452 NN denotes resistance
T1516 4437-4441 NN denotes cell
T1515 4430-4436 NN denotes glioma
T1514 4422-4429 VB denotes induces
T1513 4416-4421 NN denotes event
T1512 4412-4415 DT denotes the
T1511 4408-4411 CC denotes and
T1510 4406-4407 -COMMA- denotes ,
T1509 4397-4406 NN denotes signaling
T1508 4393-4396 NN denotes p53
T1507 4383-4392 VB denotes regulates
T1506 4372-4382 RB denotes negatively
T1505 4363-4371 NN denotes integrin
T1504 4358-4362 NN denotes α5β1
T1503 4344-4357 NN denotes chemotherapy.
T1502 4340-4343 CC denotes and
T1501 4327-4339 NN denotes radiotherapy
T1500 4324-4326 TO denotes to
T1499 4316-4323 NN denotes cancers
T1498 4307-4315 JJ denotes advanced
T1497 4304-4306 IN denotes of
T1496 4293-4303 NN denotes resistance
T1495 4289-4292 DT denotes the
T1494 4286-4288 IN denotes in
T1493 4281-4285 NN denotes role
T1492 4279-4280 DT denotes a
T1491 4274-4278 VB denotes play
T1490 4264-4273 NN denotes Integrins
T1489 4261-4262 -RRB- denotes )
T1488 4257-4261 CD denotes 2012
T1487 4255-4256 -COMMA- denotes ,
T1486 4252-4255 FW denotes al.
T1485 4249-4251 FW denotes et
T1484 4246-4248 NNP denotes Li
T1483 4245-4246 -LRB- denotes (
T1482 4239-4244 NN denotes cells
T1481 4232-4238 NN denotes cancer
T1480 4228-4231 IN denotes for
T1479 4221-4227 NN denotes factor
T1478 4208-4220 JJ denotes pro-survival
T1477 4206-4207 DT denotes a
T1476 4203-4205 IN denotes as
T1475 4192-4202 VB denotes considered
T1474 4189-4191 VB denotes is
T1473 4177-4188 NN denotes MicroRNA-21
T1472 4174-4175 -RRB- denotes )
T1471 4170-4174 CD denotes 2010
T1470 4168-4169 -COMMA- denotes ,
T1469 4165-4168 FW denotes al.
T1468 4162-4164 FW denotes et
T1467 4158-4161 NNP denotes Shi
T1466 4157-4158 -LRB- denotes (
T1465 4147-4156 NN denotes apoptosis
T1464 4135-4146 JJ denotes TMZ-induced
T1463 4126-4134 VB denotes blocking
T1462 4118-4125 RB denotes thereby
T1461 4116-4117 -COMMA- denotes ,
T1460 4108-4116 NN denotes activity
T1459 4098-4107 NN denotes caspase-3
T1458 4094-4097 CC denotes and
T1457 4088-4093 NN denotes ratio
T1456 4078-4087 NN denotes Bax/Bcl-2
T1455 4070-4077 VB denotes reduces
T1454 4058-4069 NN denotes microRNA-21
T1453 4044-4057 VB denotes overexpressed
T1452 4042-4043 -COMMA- denotes ,
T1451 4030-4042 RB denotes Intriguingly
T1450 4020-4028 NN denotes survival
T1449 4012-4019 NN denotes patient
T1448 4005-4011 NN denotes cancer
T1447 3996-4004 VB denotes prolongs
T1446 3994-3995 -COMMA- denotes ,
T1445 3984-3994 NN denotes expression
T1444 3976-3983 NN denotes protein
T1443 3971-3975 NN denotes MGMT
T1442 3964-3970 VB denotes blocks
T1441 3958-3963 WDT denotes which
T1440 3956-3957 -COMMA- denotes ,
T1439 3945-3956 NN denotes methylation
T1438 3936-3944 NN denotes promoter
T1437 3931-3935 NN denotes gene
T1436 3926-3930 NN denotes MGMT
T1435 3923-3925 IN denotes in
T1434 3914-3922 NN denotes increase
T1433 3911-3913 DT denotes An
T1432 3908-3909 -RRB- denotes )
T1431 3904-3908 CD denotes 2012
T1430 3902-3903 -COMMA- denotes ,
T1429 3899-3902 FW denotes al.
T1428 3896-3898 FW denotes et
T1427 3887-3895 FW denotes Villalva
T1426 3886-3887 -LRB- denotes (
T1425 3870-3885 NN denotes differentiation
T1424 3867-3869 TO denotes to
T1423 3857-3866 VB denotes committed
T1422 3851-3856 NN denotes cells
T1421 3848-3850 IN denotes in
T1420 3839-3847 NN denotes promoter
T1419 3834-3838 NN denotes gene
T1418 3829-3833 NN denotes MGMT
T1417 3826-3828 IN denotes of
T1416 3819-3825 NN denotes status
T1415 3807-3818 NN denotes methylation
T1414 3803-3806 DT denotes the
T1413 3798-3802 IN denotes with
T1412 3787-3797 VB denotes associated
T1411 3773-3786 RB denotes significantly
T1410 3770-3772 VB denotes is
T1409 3766-3769 NN denotes TMZ
T1408 3763-3765 TO denotes to
T1407 3751-3762 NN denotes Sensitivity
T1406 3743-3749 NN denotes system
T1405 3739-3742 NN denotes MMR
T1404 3735-3738 DT denotes the
T1403 3732-3734 IN denotes of
T1402 3724-3731 NN denotes absence
T1401 3720-3723 DT denotes the
T1400 3717-3719 IN denotes in
T1399 3711-3716 VB denotes fails
T1398 3701-3710 NN denotes signaling
T1397 3691-3700 JJ denotes apoptotic
T1396 3688-3690 IN denotes of
T1395 3677-3687 NN denotes initiation
T1394 3673-3676 DT denotes The
T1393 3670-3671 -RRB- denotes )
T1392 3666-3670 CD denotes 2008
T1391 3664-3665 -COMMA- denotes ,
T1390 3661-3664 FW denotes al.
T1389 3658-3660 FW denotes et
T1388 3649-3657 NNP denotes Sarkaria
T1387 3647-3648 -COLON- denotes ;
T1386 3643-3647 CD denotes 2008
T1385 3641-3642 -COMMA- denotes ,
T1384 3638-3641 FW denotes al.
T1383 3635-3637 FW denotes et
T1382 3630-3634 NNP denotes Hegi
T1381 3628-3629 -COLON- denotes ;
T1380 3624-3628 CD denotes 2006
T1379 3622-3623 -COMMA- denotes ,
T1378 3619-3622 FW denotes al.
T1377 3616-3618 FW denotes et
T1376 3608-3615 NNP denotes Pollack
T1375 3607-3608 -LRB- denotes (
T1374 3601-3606 NN denotes cases
T1373 3592-3600 JJ denotes clinical
T1372 3587-3591 JJ denotes many
T1371 3584-3586 IN denotes in
T1370 3573-3583 NN denotes resistance
T1369 3569-3572 NN denotes TMZ
T1368 3566-3568 TO denotes to
T1367 3552-3565 RB denotes significantly
T1366 3540-3551 VB denotes contributes
T1365 3536-3539 NN denotes MMR
T1364 3533-3535 IN denotes of
T1363 3528-3532 NN denotes loss
T1362 3525-3527 CC denotes or
T1361 3520-3524 NN denotes MGMT
T1360 3517-3519 IN denotes of
T1359 3506-3516 NN denotes expression
T1358 3501-3505 JJ denotes High
T1357 3498-3499 -RRB- denotes )
T1356 3494-3498 CD denotes 2007
T1355 3492-3493 -COMMA- denotes ,
T1354 3489-3492 FW denotes al.
T1353 3486-3488 FW denotes et
T1352 3481-3485 NNP denotes Roos
T1351 3479-3480 -COLON- denotes ;
T1350 3475-3479 CD denotes 2006
T1349 3473-3474 -COMMA- denotes ,
T1348 3465-3473 NNP denotes Edelmann
T1347 3461-3464 CC denotes and
T1346 3456-3460 NNP denotes Wang
T1345 3454-3455 -COLON- denotes ;
T1344 3450-3454 CD denotes 2004
T1343 3448-3449 -COMMA- denotes ,
T1342 3445-3448 FW denotes al.
T1341 3442-3444 FW denotes et
T1340 3433-3441 NNP denotes Caporali
T1339 3432-3433 -LRB- denotes (
T1320 3300-3310 NN denotes activation
T1319 3290-3299 VB denotes initiates
T1318 3273-3289 NN denotes O6-methylguanine
T1317 3271-3272 -COMMA- denotes ,
T1316 3265-3271 NN denotes repair
T1315 3260-3264 NN denotes MGMT
T1314 3252-3259 IN denotes Without
T1313 3249-3250 -RRB- denotes )
T1312 3244-3249 NN denotes 2012b
T1311 3242-3243 -COMMA- denotes ,
T1310 3239-3242 FW denotes al.
T1309 3236-3238 FW denotes et
T1308 3230-3235 NNP denotes Zhang
T1307 3228-3229 -COLON- denotes ;
T1306 3224-3228 CD denotes 2009
T1305 3222-3223 -COMMA- denotes ,
T1304 3219-3222 FW denotes al.
T1303 3216-3218 FW denotes et
T1302 3206-3215 NNP denotes Fukushima
T1301 3204-3205 -COLON- denotes ;
T1300 3200-3204 CD denotes 2008
T1299 3198-3199 -COMMA- denotes ,
T1298 3195-3198 FW denotes al.
T1297 3192-3194 FW denotes et
T1296 3187-3191 NNP denotes Hegi
T1295 3185-3186 -COLON- denotes ;
T1294 3181-3185 CD denotes 2006
T1293 3179-3180 -COMMA- denotes ,
T1292 3176-3179 FW denotes al.
T1291 3173-3175 FW denotes et
T1290 3165-3172 NNP denotes Pollack
T1289 3164-3165 -LRB- denotes (
T1288 3162-3163 -RRB- denotes )
T1287 3158-3162 NN denotes MGMT
T1286 3157-3158 -LRB- denotes (
T1285 3139-3156 NN denotes methyltransferase
T1284 3118-3138 NN denotes O6-methylguanine-DNA
T1283 3115-3117 IN denotes by
T1282 3108-3114 NN denotes repair
T1281 3101-3107 JJ denotes direct
T1280 3097-3100 IN denotes for
T1279 3087-3096 NN denotes substrate
T1278 3085-3086 DT denotes a
T1277 3082-3084 VB denotes is
T1276 3075-3081 NN denotes lesion
T1275 3058-3074 NN denotes O6-methylguanine
T1274 3054-3057 DT denotes The
T1273 3043-3052 NN denotes autophagy
T1272 3040-3042 IN denotes in
T1271 3031-3039 VB denotes involved
T1270 3028-3030 VB denotes is
T1269 3023-3027 NN denotes gene
T1268 3018-3022 DT denotes this
T1267 3010-3017 IN denotes whether
T1697 5533-5538 NN denotes IFN-β
T1696 5532-5533 -LRB- denotes (
T1695 5519-5531 NN denotes Interferon-β
T1694 5516-5517 -RRB- denotes )
T1693 5512-5516 CD denotes 2011
T1692 5510-5511 -COMMA- denotes ,
T1691 5507-5510 FW denotes al.
T1690 5504-5506 FW denotes et
T1689 5495-5503 NNP denotes Goellner
T1688 5494-5495 -LRB- denotes (
T1687 5490-5493 NN denotes GBM
T1686 5480-5489 JJ denotes recurrent
T1685 5476-5479 CC denotes and
T1684 5466-5475 JJ denotes resistant
T1683 5461-5465 IN denotes with
T1682 5452-5460 NN denotes patients
T1681 5449-5451 IN denotes in
T1680 5438-5448 NN denotes resistance
T1679 5434-5437 NN denotes TMZ
T1678 5426-5433 VB denotes reverse
T1677 5422-5425 MD denotes may
T1676 5409-5421 NN denotes biosynthesis
T1675 5407-5408 -RRB- denotes )
T1674 5406-5407 SYM denotes +
T1673 5405-5406 -LRB- denotes (
T1672 5402-5405 NN denotes NAD
T1671 5398-5401 CC denotes and
T1670 5391-5397 NN denotes repair
T1669 5382-5390 NN denotes excision
T1668 5377-5381 NN denotes base
T1667 5374-5376 IN denotes of
T1666 5364-5373 NN denotes targeting
T1665 5359-5363 JJ denotes Dual
T1664 5356-5357 -RRB- denotes )
T1663 5351-5356 NN denotes 2012b
T1662 5349-5350 -COMMA- denotes ,
T1661 5346-5349 FW denotes al.
T1660 5343-5345 FW denotes et
T1659 5337-5342 NNP denotes Zhang
T1658 5335-5336 -COLON- denotes ;
T1657 5331-5335 CD denotes 2011
T1656 5329-5330 -COMMA- denotes ,
T1655 5326-5329 FW denotes al.
T1654 5323-5325 FW denotes et
T1653 5314-5322 NNP denotes Goellner
T1652 5313-5314 -LRB- denotes (
T1651 5303-5312 VB denotes tolerated
T1650 5300-5302 CC denotes or
T1649 5291-5299 VB denotes repaired
T1648 5287-5290 VB denotes are
T1647 5279-5286 NN denotes adducts
T1646 5262-5278 NN denotes O6-methylguanine
T1645 5257-5261 WRB denotes when
T1644 5244-5256 RB denotes particularly
T1643 5231-5243 NN denotes cytotoxicity
T1642 5227-5230 NN denotes TMZ
T1641 5224-5226 TO denotes to
T1640 5210-5223 RB denotes significantly
T1639 5198-5209 VB denotes contributes
T1638 5191-5197 NN denotes repair
T1637 5182-5190 NN denotes excision
T1636 5177-5181 NN denotes base
T1635 5174-5176 IN denotes of
T1634 5153-5173 NN denotes Methoxyamine-blocker
T1633 5150-5151 -RRB- denotes )
T1632 5145-5150 NN denotes 2012b
T1631 5143-5144 -COMMA- denotes ,
T1630 5140-5143 FW denotes al.
T1629 5137-5139 FW denotes et
T1628 5131-5136 NNP denotes Zhang
T1627 5130-5131 -LRB- denotes (
T1626 5126-5129 NN denotes TMZ
T1625 5123-5125 TO denotes to
T1624 5116-5122 NN denotes tumors
T1623 5106-5115 VB denotes sensitize
T1622 5103-5105 TO denotes to
T1621 5091-5102 NN denotes lomeguatrib
T1620 5087-5090 CC denotes and
T1619 5070-5086 NN denotes O6-benzylguanine
T1618 5068-5069 -COMMA- denotes ,
T1617 5052-5068 NN denotes pseudosubstrates
T1616 5047-5051 NN denotes MGMT
T1615 5044-5046 IN denotes by
T1614 5035-5043 VB denotes achieved
T1613 5032-5034 VB denotes be
T1612 5028-5031 MD denotes may
T1611 5017-5027 NN denotes resistance
T1610 5013-5016 NN denotes TMZ
T1609 5010-5012 IN denotes of
T1608 5001-5009 NN denotes Reversal
T1607 4998-4999 -RRB- denotes )
T1606 4994-4998 CD denotes 2011
T1605 4992-4993 -COMMA- denotes ,
T1604 4989-4992 FW denotes al.
T1603 4986-4988 FW denotes et
T1602 4980-4985 NNP denotes Oliva
T1601 4979-4980 -LRB- denotes (
T1600 4971-4978 NN denotes gliomas
T1599 4968-4970 IN denotes in
T1598 4957-4967 NN denotes resistance
T1597 4953-4956 NN denotes TMZ
T1596 4950-4952 TO denotes to
T1595 4945-4949 NN denotes part
T1594 4942-4944 IN denotes in
T1593 4930-4941 VB denotes contributes
T1592 4922-4929 NN denotes oxidase
T1591 4920-4921 NN denotes c
T1590 4909-4919 NN denotes cytochrome
T1589 4906-4908 IN denotes by
T1588 4896-4905 VB denotes regulated
T1587 4894-4895 -RRB- denotes )
T1586 4891-4894 NN denotes ROS
T1585 4890-4891 -LRB- denotes (
T1584 4882-4889 NN denotes species
T1583 4875-4881 NN denotes oxygen
T1582 4866-4874 JJ denotes reactive
T1581 4863-4865 IN denotes of
T1580 4852-4862 NN denotes production
T1579 4848-4851 DT denotes the
T1578 4839-4847 VB denotes suppress
T1577 4836-4838 TO denotes to
T1576 4827-4835 NN denotes coupling
T1575 4821-4826 NN denotes chain
T1574 4809-4820 JJ denotes respiratory
T1573 4795-4808 JJ denotes mitochondrial
T1572 4792-4794 IN denotes of
T1571 4779-4791 NN denotes Upregulation
T1570 4776-4777 -RRB- denotes )
T1569 4772-4776 CD denotes 2012
T1568 4770-4771 -COMMA- denotes ,
T1567 4767-4770 FW denotes al.
T1566 4764-4766 FW denotes et
T1565 4754-4763 NNP denotes Agnihotri
T1564 4753-4754 -LRB- denotes (
T1563 4742-4752 NN denotes resistance
T1562 4738-4741 NN denotes TMZ
T1561 4734-4737 DT denotes the
T1560 4731-4733 IN denotes in
T1559 4718-4730 VB denotes participates
T1558 4713-4717 RB denotes also
T1557 4711-4712 -COMMA- denotes ,
T1556 4695-4711 NN denotes N7-methylguanine
T1555 4691-4694 CC denotes and
T1266 2999-3009 VB denotes determined
T1265 2995-2998 RB denotes not
T1264 2992-2994 VB denotes is
T1263 2989-2991 PRP denotes It
T1262 2980-2987 NN denotes protein
T1261 2973-2979 JJ denotes 37-kDa
T1260 2967-2972 JJ denotes novel
T1259 2965-2966 DT denotes a
T1258 2957-2964 VB denotes encodes
T1257 2952-2956 NN denotes gene
T1256 2946-2951 NN denotes MAPO2
T1255 2943-2944 -RRB- denotes )
T1254 2939-2943 CD denotes 2012
T1253 2937-2938 -COMMA- denotes ,
T1252 2934-2937 FW denotes al.
T1251 2931-2933 FW denotes et
T1250 2922-2930 NNP denotes Fujikane
T1249 2921-2922 -LRB- denotes (
T1248 2911-2920 NN denotes apoptosis
T1247 2896-2910 JJ denotes lesion-induced
T1246 2879-2895 NN denotes O6-methylguanine
T1245 2875-2878 DT denotes the
T1244 2872-2874 IN denotes in
T1243 2859-2871 VB denotes participates
T1242 2854-2858 NN denotes gene
T1241 2852-2853 -RRB- denotes )
T1240 2844-2852 NN denotes C1orf201
T1239 2843-2844 -LRB- denotes (
T1238 2837-2842 NN denotes MAPO2
T1237 2835-2836 -COMMA- denotes ,
T1236 2831-2835 RB denotes Also
T1235 2828-2829 -RRB- denotes )
T1234 2824-2828 CD denotes 2013
T1233 2822-2823 -COMMA- denotes ,
T1232 2819-2822 FW denotes al.
T1231 2816-2818 FW denotes et
T1230 2807-2815 NNP denotes Knizhnik
T1229 2806-2807 -LRB- denotes (
T1228 2800-2805 NN denotes cells
T1227 2796-2799 NN denotes GBM
T1226 2793-2795 IN denotes in
T1225 2783-2792 NN denotes apoptosis
T1224 2774-2782 JJ denotes eventual
T1223 2770-2773 DT denotes the
T1222 2764-2769 VB denotes block
T1221 2760-2763 MD denotes may
T1220 2756-2759 CC denotes and
T1219 2754-2755 -COMMA- denotes ,
T1218 2742-2754 JJ denotes pro-survival
T1217 2739-2741 VB denotes is
T1216 2729-2738 NN denotes autophagy
T1215 2717-2728 JJ denotes TMZ-induced
T1214 2712-2716 IN denotes that
T1213 2699-2711 VB denotes demonstrated
T1212 2693-2698 NN denotes study
T1211 2686-2692 JJ denotes recent
T1210 2684-2685 DT denotes a
T1209 2682-2683 -COMMA- denotes ,
T1208 2675-2682 RB denotes However
T1207 2672-2673 -RRB- denotes )
T1206 2668-2672 CD denotes 2010
T1205 2666-2667 -COMMA- denotes ,
T1204 2663-2666 FW denotes al.
T1203 2660-2662 FW denotes et
T1202 2655-2659 NNP denotes Voss
T1201 2654-2655 -LRB- denotes (
T1200 2650-2653 NN denotes TMZ
T1199 2647-2649 IN denotes of
T1198 2640-2646 NN denotes action
T1197 2636-2639 DT denotes the
T1196 2627-2635 VB denotes enhances
T1195 2623-2626 CC denotes and
T1194 2615-2622 NN denotes gliomas
T1193 2612-2614 IN denotes in
T1192 2606-2611 NN denotes death
T1191 2595-2605 JJ denotes autophagic
T1190 2592-2594 TO denotes to
T1189 2586-2591 VB denotes leads
T1188 2576-2585 NN denotes -gossypol
T1187 2575-2576 -RRB- denotes )
T1186 2574-2575 LS denotes −
T1185 2573-2574 -LRB- denotes (
T1184 2563-2572 NN denotes inhibitor
T1183 2553-2562 NN denotes pan-Bcl-2
T1182 2551-2552 DT denotes a
T1181 2548-2550 IN denotes by
T1180 2542-2547 NN denotes Bcl-2
T1179 2528-2541 JJ denotes antiapoptotic
T1178 2525-2527 IN denotes of
T1177 2514-2524 NN denotes inhibition
T1176 2512-2513 -COMMA- denotes ,
T1175 2508-2512 RB denotes Also
T1174 2505-2506 -RRB- denotes )
T1173 2501-2505 CD denotes 2003
T1172 2499-2500 -COMMA- denotes ,
T1171 2496-2499 FW denotes al.
T1170 2493-2495 FW denotes et
T1169 2485-2492 NNP denotes Kanzawa
T1168 2484-2485 -LRB- denotes (
T1167 2478-2483 NN denotes death
T1166 2473-2477 NN denotes cell
T1165 2467-2472 VB denotes cause
T1164 2464-2466 TO denotes to
T1163 2462-2463 -COMMA- denotes ,
T1162 2453-2462 NN denotes apoptosis
T1161 2448-2452 IN denotes than
T1160 2441-2447 RB denotes rather
T1159 2439-2440 -COMMA- denotes ,
T1158 2430-2439 NN denotes autophagy
T1157 2422-2429 VB denotes trigger
T1156 2419-2421 TO denotes to
T1155 2413-2418 VB denotes known
T1154 2410-2412 VB denotes is
T1153 2403-2409 NN denotes lesion
T1152 2386-2402 NN denotes O6-methylguanine
T1151 2382-2385 DT denotes The
T1150 2379-2380 -RRB- denotes )
T1149 2374-2379 NN denotes 2012b
T1148 2372-2373 -COMMA- denotes ,
T1147 2369-2372 FW denotes al.
T1146 2366-2368 FW denotes et
T1145 2360-2365 NNP denotes Zhang
T1144 2358-2359 -COLON- denotes ;
T1143 2354-2358 CD denotes 2011
T1142 2352-2353 -COMMA- denotes ,
T1141 2349-2352 FW denotes al.
T1140 2346-2348 FW denotes et
T1139 2337-2345 NNP denotes Goellner
T1138 2336-2337 -LRB- denotes (
T1137 2319-2335 NN denotes N7-methylguanine
T1136 2315-2318 CC denotes and
T1135 2313-2314 -COMMA- denotes ,
T1134 2297-2313 NN denotes N3-methyladenine
T1133 2295-2296 -COMMA- denotes ,
T1132 2279-2295 NN denotes O6-methylguanine
T1131 2269-2278 VB denotes including
T1130 2267-2268 -COMMA- denotes ,
T1129 2260-2267 NN denotes lesions
T1128 2256-2259 NN denotes DNA
T1127 2253-2255 IN denotes of
T1126 2242-2252 NN denotes generation
T1125 2234-2241 VB denotes induces
T1124 2221-2233 NN denotes Temozolomide
T1123 2218-2219 -RRB- denotes )
T1122 2213-2218 NN denotes 2012b
T1121 2211-2212 -COMMA- denotes ,
T1120 2208-2211 FW denotes al.
T1119 2205-2207 FW denotes et
T1118 2199-2204 NNP denotes Zhang
T1117 2197-2198 -COLON- denotes ;
T1116 2193-2197 CD denotes 2012
T1115 2191-2192 -COMMA- denotes ,
T1114 2188-2191 FW denotes al.
T1113 2185-2187 FW denotes et
T1112 2177-2184 NNP denotes Kohsaka
T1111 2175-2176 -COLON- denotes ;
T1110 2171-2175 CD denotes 2012
T1109 2169-2170 -COMMA- denotes ,
T1108 2166-2169 FW denotes al.
T1107 2163-2165 FW denotes et
T1106 2155-2162 NNP denotes Kitange
T1105 2153-2154 -COLON- denotes ;
T1085 2069-2073 JJ denotes many
T1084 2065-2068 CC denotes and
T1083 2063-2064 -COMMA- denotes ,
T1082 2057-2063 NN denotes kinase
T1081 2051-2056 NN denotes STAT3
T1080 2049-2050 -COMMA- denotes ,
T1079 2039-2049 NN denotes transition
T1078 2016-2038 JJ denotes epithelial-mesenchymal
T1077 2014-2015 -COMMA- denotes ,
T1076 2001-2014 NN denotes deacetylation
T1075 1993-2000 NN denotes histone
T1074 1991-1992 -COMMA- denotes ,
T1073 1984-1991 NN denotes hypoxia
T1072 1978-1983 IN denotes under
T1071 1972-1977 NN denotes cells
T1070 1966-1971 NN denotes tumor
T1069 1964-1965 -COMMA- denotes ,
T1068 1958-1964 NN denotes repair
T1067 1951-1957 NN denotes damage
T1066 1947-1950 NN denotes DNA
T1065 1945-1946 -COMMA- denotes ,
T1064 1939-1945 NN denotes efflux
T1063 1934-1938 NN denotes drug
T1062 1932-1933 -COMMA- denotes ,
T1061 1923-1932 NN denotes microRNAs
T1060 1921-1922 -COMMA- denotes ,
T1059 1916-1921 NN denotes cells
T1058 1911-1915 NN denotes stem
T1057 1904-1910 NN denotes cancer
T1056 1896-1903 VB denotes include
T1055 1892-1895 MD denotes may
T1054 1886-1891 WDT denotes which
T1053 1884-1885 -COMMA- denotes ,
T1052 1874-1884 NN denotes resistance
T1051 1870-1873 NN denotes TMZ
T1050 1866-1869 DT denotes the
T1049 1863-1865 IN denotes in
T1048 1854-1862 VB denotes involved
T1047 1850-1853 VB denotes are
T1046 1839-1849 NN denotes mechanisms
T1045 1830-1838 JJ denotes Multiple
T1044 1827-1828 -RRB- denotes )
T1043 1823-1827 CD denotes 2010
T1042 1821-1822 -COMMA- denotes ,
T1041 1812-1821 NNP denotes Nishikawa
T1040 1810-1811 -COLON- denotes ;
T1039 1806-1810 CD denotes 2000
T1038 1804-1805 -COMMA- denotes ,
T1037 1801-1804 FW denotes al.
T1036 1798-1800 FW denotes et
T1035 1789-1797 NNP denotes Friedman
T1034 1788-1789 -LRB- denotes (
T1033 1786-1787 -RRB- denotes )
T1338 3426-3431 NN denotes death
T1337 3421-3425 NN denotes cell
T1336 3411-3420 JJ denotes apoptotic
T1335 3408-3410 TO denotes to
T1334 3402-3407 VB denotes leads
T1333 3391-3401 RB denotes ultimately
T1332 3386-3390 WDT denotes that
T1331 3379-3385 NN denotes kinase
T1330 3371-3378 NN denotes protein
T1329 3358-3370 JJ denotes Rad3-related
T1328 3355-3357 CC denotes or
T1327 3346-3354 NN denotes proteins
T1326 3344-3345 -RRB- denotes )
T1325 3341-3344 NN denotes MMR
T1324 3340-3341 -LRB- denotes (
T1323 3323-3339 JJ denotes repair-deficient
T1322 3314-3322 NN denotes mismatch
T1321 3311-3313 IN denotes of
T1032 1783-1786 NN denotes TMZ
T1031 1782-1783 -LRB- denotes (
T1030 1769-1781 NN denotes temozolomide
T1029 1763-1768 NN denotes agent
T1028 1752-1762 VB denotes alkylating
T1027 1737-1751 JJ denotes monofunctional
T1026 1733-1736 DT denotes the
T1025 1728-1732 IN denotes with
T1024 1718-1727 NN denotes treatment
T1023 1714-1717 CC denotes and
T1022 1712-1713 -COMMA- denotes ,
T1021 1703-1712 NN denotes radiation
T1020 1701-1702 -COMMA- denotes ,
T1019 1694-1701 NN denotes surgery
T1018 1684-1693 VB denotes debulking
T1017 1676-1683 JJ denotes maximum
T1016 1667-1675 VB denotes includes
T1015 1660-1666 RB denotes mainly
T1014 1656-1659 NN denotes GBM
T1013 1652-1655 IN denotes for
T1012 1644-1651 NN denotes therapy
T1011 1635-1643 JJ denotes standard
T1010 1627-1634 JJ denotes current
T1009 1623-1626 DT denotes The
T1008 1620-1621 -RRB- denotes )
T1007 1616-1620 CD denotes 2012
T1006 1614-1615 -COMMA- denotes ,
T1005 1611-1614 FW denotes al.
T1004 1608-1610 FW denotes et
T1003 1600-1607 NNP denotes Happold
T1002 1598-1599 -COLON- denotes ;
T1001 1594-1598 CD denotes 2012
T1000 1592-1593 -COMMA- denotes ,
T999 1589-1592 FW denotes al.
T998 1586-1588 FW denotes et
T997 1581-1585 NNP denotes Haar
T996 1580-1581 -LRB- denotes (
T995 1571-1579 NN denotes patients
T994 1568-1570 IN denotes in
T993 1563-1567 VB denotes seen
T992 1552-1562 RB denotes frequently
T991 1548-1551 VB denotes are
T990 1540-1547 NN denotes relapse
T989 1533-1539 NN denotes cancer
T988 1529-1532 CC denotes and
T987 1518-1528 NN denotes modalities
T986 1506-1517 JJ denotes therapeutic
T985 1498-1505 JJ denotes current
T984 1495-1497 TO denotes to
T983 1484-1494 NN denotes resistance
T982 1481-1483 IN denotes of
T981 1474-1480 NN denotes levels
T980 1469-1473 JJ denotes High
T979 1466-1467 -RRB- denotes )
T978 1462-1466 CD denotes 2009
T977 1460-1461 -COMMA- denotes ,
T976 1457-1460 FW denotes al.
T975 1454-1456 FW denotes et
T974 1448-1453 NNP denotes Stupp
T973 1446-1447 -COLON- denotes ;
T972 1442-1446 CD denotes 2000
T971 1440-1441 -COMMA- denotes ,
T970 1437-1440 FW denotes al.
T969 1434-1436 FW denotes et
T968 1425-1433 NNP denotes Friedman
T967 1424-1425 -LRB- denotes (
T966 1422-1423 NN denotes %
T965 1419-1422 CD denotes 9.8
T964 1414-1418 RB denotes only
T963 1411-1413 VB denotes is
T962 1407-1410 NN denotes GBM
T961 1403-1406 IN denotes for
T960 1398-1402 NN denotes rate
T959 1389-1397 NN denotes survival
T958 1382-1388 JJ denotes 5-year
T957 1374-1381 JJ denotes overall
T956 1370-1373 DT denotes the
T955 1366-1369 CC denotes and
T954 1364-1365 -COMMA- denotes ,
T953 1353-1364 NN denotes 14.6 months
T952 1350-1352 VB denotes is
T951 1339-1349 NN denotes expectancy
T950 1330-1338 NN denotes survival
T949 1322-1329 JJ denotes average
T948 1318-1321 DT denotes the
T947 1314-1317 CC denotes and
T946 1312-1313 -COMMA- denotes ,
T945 1306-1312 JJ denotes lethal
T944 1299-1305 RB denotes highly
T943 1296-1298 VB denotes is
T942 1294-1295 -RRB- denotes )
T941 1291-1294 NN denotes GBM
T940 1290-1291 -LRB- denotes (
T939 1277-1289 NN denotes Glioblastoma
T938 1274-1275 -RRB- denotes )
T937 1270-1274 CD denotes 2012
T936 1268-1269 -COMMA- denotes ,
T935 1265-1268 FW denotes al.
T934 1262-1264 FW denotes et
T933 1255-1261 NNP denotes Silber
T932 1253-1254 -COLON- denotes ;
T931 1249-1253 CD denotes 2009
T930 1247-1248 -COMMA- denotes ,
T929 1244-1247 FW denotes al.
T928 1241-1243 FW denotes et
T927 1235-1240 NNP denotes Stupp
T926 1233-1234 -COLON- denotes ;
T925 1229-1233 CD denotes 2000
T924 1227-1228 -COMMA- denotes ,
T923 1224-1227 FW denotes al.
T922 1221-1223 FW denotes et
T921 1212-1220 NNP denotes Friedman
T920 1211-1212 -LRB- denotes (
T919 1202-1210 RB denotes annually
T918 1197-1201 NNP denotes U.S.
T917 1193-1196 DT denotes the
T916 1190-1192 IN denotes in
T915 1181-1189 NN denotes patients
T914 1177-1180 JJ denotes new
T913 1170-1176 CD denotes 12,500
T912 1161-1169 NN denotes afflicts
T911 1150-1160 JJ denotes multiforme
T1104 2149-2153 CD denotes 2012
T1103 2147-2148 -COMMA- denotes ,
T1102 2139-2147 NNP denotes Bjerkvig
T1101 2135-2138 CC denotes and
T1100 2123-2134 NNP denotes Johannessen
T1099 2121-2122 -COLON- denotes ;
T1098 2117-2121 CD denotes 2012
T1097 2115-2116 -COMMA- denotes ,
T1096 2112-2115 FW denotes al.
T1095 2109-2111 FW denotes et
T1094 2101-2108 NNP denotes Happold
T1093 2099-2100 -COLON- denotes ;
T1092 2095-2099 CD denotes 2012
T1091 2093-2094 -COMMA- denotes ,
T1090 2090-2093 FW denotes al.
T1089 2087-2089 FW denotes et
T1088 2082-2086 NNP denotes Haar
T1087 2081-2082 -LRB- denotes (
T336 1071-1076 NN denotes death
T335 1066-1070 NN denotes cell
T334 1062-1065 NN denotes GBM
T333 1055-1061 VB denotes induce
T332 1051-1054 CC denotes and
T331 1040-1050 NN denotes resistance
T330 1036-1039 NN denotes TMZ
T329 1027-1035 VB denotes overcome
T328 1024-1026 TO denotes to
T327 1017-1023 VB denotes needed
T326 1014-1016 VB denotes is
T325 1003-1013 NN denotes deficiency
T324 992-1002 JJ denotes functional
T323 988-991 NN denotes p53
T322 982-987 IN denotes under
T321 976-981 NN denotes drugs
T320 964-975 JJ denotes therapeutic
T319 961-963 IN denotes by
T318 950-960 NN denotes activation
T317 945-949 NN denotes WWOX
T316 934-944 VB denotes triggering
T315 929-933 IN denotes that
T314 921-928 VB denotes propose
T313 918-920 PRP denotes We
T312 912-916 NN denotes WWOX
T311 909-911 IN denotes of
T310 900-908 NN denotes function
T309 890-899 JJ denotes apoptotic
T308 886-889 DT denotes the
T307 877-885 VB denotes modulate
T306 875-876 -COMMA- denotes ,
T305 867-875 NN denotes isoforms
T304 864-866 CC denotes or
T303 862-863 -COMMA- denotes ,
T302 859-862 NN denotes p53
T301 852-858 JJ denotes mutant
T300 848-851 CC denotes and
T299 843-847 NN denotes type
T298 838-842 JJ denotes wild
T297 833-837 IN denotes that
T296 823-832 NN denotes scenarios
T295 813-822 JJ denotes potential
T294 803-812 VB denotes postulate
T293 799-802 CC denotes and
T292 797-798 -COMMA- denotes ,
T291 793-797 NN denotes WWOX
T290 789-792 CC denotes and
T289 785-788 NN denotes p53
T288 782-784 IN denotes in
T287 772-781 NN denotes knowledge
T286 764-771 VB denotes updated
T285 760-763 DT denotes the
T284 756-759 IN denotes for
T283 747-755 NN denotes overview
T282 744-746 DT denotes an
T281 736-743 VB denotes provide
T280 733-735 PRP denotes we
T279 731-732 -COMMA- denotes ,
T278 727-731 RB denotes Here
T277 722-725 NN denotes p53
T276 717-721 NN denotes type
T275 712-716 JJ denotes wild
T274 702-711 VB denotes stabilize
T273 698-701 CC denotes and
T272 693-697 VB denotes bind
T271 682-692 RB denotes physically
T270 679-681 TO denotes to
T269 673-678 VB denotes known
T268 670-672 VB denotes is
T267 665-669 NN denotes WWOX
T266 660-663 NN denotes p53
T265 653-659 JJ denotes mutant
T264 643-652 VB denotes harboring
T263 637-642 NN denotes cells
T262 624-636 NN denotes glioblastoma
T261 618-623 JJ denotes human
T260 615-617 IN denotes in
T259 605-614 NN denotes apoptosis
T258 597-604 VB denotes induces
T257 582-596 RB denotes preferentially
T256 577-581 NN denotes WWOX
T255 572-576 NN denotes type
T254 567-571 JJ denotes wild
T253 564-566 IN denotes of
T252 553-563 NN denotes expression
T251 545-552 JJ denotes ectopic
T250 543-544 -COMMA- denotes ,
T249 531-543 RB denotes Intriguingly
T248 521-529 NN denotes blockade
T247 507-520 JJ denotes translational
T246 503-506 CC denotes and
T245 501-502 -COMMA- denotes ,
T244 490-501 NN denotes alterations
T243 482-489 JJ denotes genetic
T242 480-481 -COMMA- denotes ,
T241 464-480 NN denotes hypermethylation
T240 455-463 NN denotes promoter
T239 452-454 TO denotes to
T238 448-451 JJ denotes due
T237 442-447 NN denotes cells
T236 435-441 NN denotes cancer
T235 425-434 JJ denotes malignant
T234 422-424 IN denotes in
T233 417-421 VB denotes seen
T232 406-416 RB denotes frequently
T231 403-405 VB denotes is
T230 392-402 NN denotes expression
T229 387-391 NN denotes gene
T228 382-386 NN denotes WWOX
T227 379-381 IN denotes of
T226 374-378 NN denotes Loss
T225 362-372 NN denotes suppressor
T224 356-361 NN denotes tumor
T223 354-355 DT denotes a
T222 351-353 IN denotes as
T221 340-350 VB denotes considered
T220 337-339 VB denotes is
T219 333-336 CC denotes and
T218 325-332 NN denotes protein
T217 312-324 JJ denotes proapoptotic
T216 310-311 DT denotes a
T215 307-309 VB denotes is
T214 305-306 -RRB- denotes )
T213 301-305 NN denotes WOX1
T212 298-300 CC denotes or
T211 294-297 NN denotes FOR
T210 293-294 -LRB- denotes (
T209 288-292 NN denotes WWOX
T208 273-287 NN denotes oxidoreductase
T207 255-272 JJ denotes domain-containing
T206 252-254 JJ denotes WW
T205 245-250 NN denotes drugs
T204 233-244 JJ denotes therapeutic
T203 229-232 CC denotes and
T202 227-228 -RRB- denotes )
T201 224-227 NN denotes TMZ
T200 223-224 -LRB- denotes (
T199 210-222 NN denotes temozolomide
T198 207-209 TO denotes to
T197 196-206 NN denotes resistance
T196 193-195 TO denotes to
T195 191-192 -COMMA- denotes ,
T194 187-191 NN denotes part
T193 184-186 IN denotes in
T192 182-183 -COMMA- denotes ,
T191 172-182 VB denotes contribute
T190 169-171 TO denotes to
T189 161-168 VB denotes appears
T188 157-160 CC denotes and
T187 155-156 -RRB- denotes )
T186 151-155 NN denotes GBMs
T185 150-151 -LRB- denotes (
T184 136-149 NN denotes glioblastomas
T183 133-135 IN denotes in
T182 125-132 VB denotes mutated
T181 114-124 RB denotes frequently
T180 110-113 VB denotes are
T179 106-109 NN denotes p53
T178 95-105 NN denotes suppressor
T177 89-94 NN denotes Tumor
T910 1137-1149 NN denotes Glioblastoma
T13201 8382-8387 JJ denotes first
T6867 12874-12883 VB denotes Activated
R152 T287 T286 arg2Of knowledge,updated
R1378 T1834 T1835 arg1Of complicated,than
R3583 T4983 T4982 arg1Of activity,promoter
R5391 T7760 T7759 arg2Of dent and -in,pen
R5392 T7761 T7757 arg2Of depende,ss
R5393 T7761 T7758 arg1Of depende,ion in p53-de
R5394 T7761 T7760 arg1Of depende,dent and -in
R5395 T7761 T7762 arg1Of depende,n
R6057 T8786 T8783 arg2Of determined,remains
R6058 T8786 T8784 arg1Of determined,to
R7520 T10908 T10924 arg1Of We,discussed
R7521 T10910 T10909 arg2Of shown,have
R7522 T10910 T10923 arg1Of shown,and
R7523 T10912 T10910 arg2Of role,shown
R9836 T14302 T14299 arg1Of induce,","
R9837 T14302 T14304 arg1Of induce,in
R28 T168 T166 arg1Of WWOX,Tumor
R29 T168 T167 arg1Of WWOX,Suppressor
R30 T168 T169 arg1Of WWOX,and
R31 T169 T175 arg1Of and,in
R32 T171 T170 arg1Of Alterations,p53
R33 T171 T172 arg1Of Alterations,and
R34 T172 T169 arg2Of and,and
R35 T174 T172 arg2Of Resistance,and
R36 T174 T173 arg1Of Resistance,Drug
R37 T176 T175 arg2Of Glioblastomas,in
R38 T179 T177 arg1Of p53,Tumor
R39 T179 T178 arg1Of p53,suppressor
R40 T179 T180 arg1Of p53,are
R41 T179 T182 arg2Of p53,mutated
R42 T179 T189 arg1Of p53,appears
R43 T179 T191 arg1Of p53,contribute
R44 T182 T180 arg2Of mutated,are
R45 T182 T181 arg1Of mutated,frequently
R46 T182 T183 arg1Of mutated,in
R47 T182 T188 arg1Of mutated,and
R48 T184 T183 arg2Of glioblastomas,in
R49 T184 T185 arg1Of glioblastomas,(
R50 T186 T185 arg2Of GBMs,(
R51 T187 T185 arg3Of ),(
R52 T189 T188 arg2Of appears,and
R53 T191 T189 arg2Of contribute,appears
R54 T191 T190 arg1Of contribute,to
R55 T191 T192 arg1Of contribute,","
R56 T191 T193 arg1Of contribute,in
R57 T191 T195 arg1Of contribute,","
R58 T191 T196 arg1Of contribute,to
R59 T194 T193 arg2Of part,in
R60 T197 T198 arg1Of resistance,to
R61 T197 T203 arg1Of resistance,and
R62 T199 T198 arg2Of temozolomide,to
R63 T199 T200 arg1Of temozolomide,(
R64 T201 T200 arg2Of TMZ,(
R65 T202 T200 arg3Of ),(
R66 T203 T196 arg2Of and,to
R67 T205 T203 arg2Of drugs,and
R68 T205 T204 arg1Of drugs,therapeutic
R69 T209 T206 arg1Of WWOX,WW
R70 T209 T207 arg1Of WWOX,domain-containing
R71 T209 T208 arg1Of WWOX,oxidoreductase
R72 T209 T210 arg1Of WWOX,(
R73 T209 T215 arg1Of WWOX,is
R74 T209 T220 arg1Of WWOX,is
R75 T209 T221 arg2Of WWOX,considered
R76 T211 T212 arg1Of FOR,or
R77 T212 T210 arg2Of or,(
R78 T213 T212 arg2Of WOX1,or
R79 T214 T210 arg3Of ),(
R80 T215 T219 arg1Of is,and
R81 T218 T215 arg2Of protein,is
R82 T218 T216 arg1Of protein,a
R83 T218 T217 arg1Of protein,proapoptotic
R84 T221 T219 arg2Of considered,and
R85 T221 T220 arg2Of considered,is
R86 T221 T222 arg1Of considered,as
R87 T225 T222 arg2Of suppressor,as
R88 T225 T223 arg1Of suppressor,a
R89 T225 T224 arg1Of suppressor,tumor
R90 T226 T227 arg1Of Loss,of
R91 T226 T231 arg1Of Loss,is
R92 T226 T233 arg2Of Loss,seen
R93 T230 T227 arg2Of expression,of
R94 T230 T228 arg1Of expression,WWOX
R95 T230 T229 arg1Of expression,gene
R96 T233 T231 arg2Of seen,is
R97 T233 T232 arg1Of seen,frequently
R98 T233 T234 arg1Of seen,in
R99 T233 T239 arg1Of seen,to
R100 T237 T234 arg2Of cells,in
R101 T237 T235 arg1Of cells,malignant
R102 T237 T236 arg1Of cells,cancer
R103 T237 T238 arg1Of cells,due
R104 T241 T240 arg1Of hypermethylation,promoter
R105 T241 T242 arg1Of hypermethylation,","
R106 T242 T246 arg1Of ",",and
R107 T244 T242 arg2Of alterations,","
R108 T244 T243 arg1Of alterations,genetic
R109 T246 T239 arg2Of and,to
R110 T246 T245 arg1Of and,","
R111 T248 T246 arg2Of blockade,and
R112 T248 T247 arg1Of blockade,translational
R113 T252 T251 arg1Of expression,ectopic
R114 T252 T253 arg1Of expression,of
R115 T252 T258 arg1Of expression,induces
R116 T256 T253 arg2Of WWOX,of
R117 T256 T254 arg1Of WWOX,wild
R118 T256 T255 arg1Of WWOX,type
R119 T258 T249 arg1Of induces,Intriguingly
R120 T258 T250 arg1Of induces,","
R121 T258 T257 arg1Of induces,preferentially
R122 T258 T260 arg1Of induces,in
R123 T259 T258 arg2Of apoptosis,induces
R124 T263 T260 arg2Of cells,in
R125 T263 T261 arg1Of cells,human
R126 T263 T262 arg1Of cells,glioblastoma
R127 T263 T264 arg1Of cells,harboring
R128 T266 T264 arg2Of p53,harboring
R129 T266 T265 arg1Of p53,mutant
R130 T267 T268 arg1Of WWOX,is
R131 T267 T269 arg2Of WWOX,known
R132 T267 T272 arg1Of WWOX,bind
R133 T267 T274 arg1Of WWOX,stabilize
R134 T269 T268 arg2Of known,is
R135 T272 T273 arg1Of bind,and
R136 T273 T269 arg3Of and,known
R137 T273 T270 arg1Of and,to
R138 T273 T271 arg1Of and,physically
R139 T274 T273 arg2Of stabilize,and
R140 T277 T272 arg2Of p53,bind
R141 T277 T274 arg2Of p53,stabilize
R142 T277 T275 arg1Of p53,wild
R143 T277 T276 arg1Of p53,type
R144 T280 T281 arg1Of we,provide
R145 T280 T294 arg1Of we,postulate
R146 T281 T293 arg1Of provide,and
R147 T283 T281 arg2Of overview,provide
R148 T283 T282 arg1Of overview,an
R149 T283 T284 arg1Of overview,for
R150 T287 T284 arg2Of knowledge,for
R151 T287 T285 arg1Of knowledge,the
R153 T287 T288 arg1Of knowledge,in
R154 T289 T290 arg1Of p53,and
R155 T290 T288 arg2Of and,in
R156 T291 T290 arg2Of WWOX,and
R157 T293 T278 arg1Of and,Here
R158 T293 T279 arg1Of and,","
R159 T293 T292 arg1Of and,","
R160 T294 T293 arg2Of postulate,and
R161 T296 T294 arg2Of scenarios,postulate
R162 T296 T295 arg1Of scenarios,potential
R163 T296 T297 arg1Of scenarios,that
R164 T299 T298 arg1Of type,wild
R165 T299 T300 arg1Of type,and
R166 T300 T304 arg1Of and,or
R167 T302 T300 arg2Of p53,and
R168 T302 T301 arg1Of p53,mutant
R169 T304 T303 arg1Of or,","
R170 T304 T307 arg1Of or,modulate
R171 T305 T304 arg2Of isoforms,or
R172 T307 T297 arg2Of modulate,that
R173 T307 T306 arg1Of modulate,","
R174 T310 T307 arg2Of function,modulate
R175 T310 T308 arg1Of function,the
R176 T310 T309 arg1Of function,apoptotic
R177 T310 T311 arg1Of function,of
R178 T312 T311 arg2Of WWOX,of
R179 T313 T314 arg1Of We,propose
R180 T318 T316 arg1Of activation,triggering
R181 T318 T317 arg1Of activation,WWOX
R182 T318 T319 arg1Of activation,by
R183 T318 T322 arg1Of activation,under
R184 T318 T326 arg1Of activation,is
R185 T318 T327 arg2Of activation,needed
R186 T321 T319 arg2Of drugs,by
R187 T321 T320 arg1Of drugs,therapeutic
R188 T325 T322 arg2Of deficiency,under
R189 T325 T323 arg1Of deficiency,p53
R190 T325 T324 arg1Of deficiency,functional
R191 T327 T314 arg2Of needed,propose
R192 T327 T315 arg1Of needed,that
R193 T327 T326 arg2Of needed,is
R194 T327 T328 modOf needed,to
R195 T329 T332 arg1Of overcome,and
R196 T331 T329 arg2Of resistance,overcome
R197 T331 T330 arg1Of resistance,TMZ
R198 T332 T328 arg1Of and,to
R199 T333 T332 arg2Of induce,and
R200 T336 T333 arg2Of death,induce
R201 T336 T334 arg1Of death,GBM
R202 T336 T335 arg1Of death,cell
R466 T915 T912 arg1Of patients,afflicts
R467 T915 T913 arg1Of patients,"12,500"
R468 T915 T914 arg1Of patients,new
R469 T915 T916 arg1Of patients,in
R470 T915 T919 arg1Of patients,annually
R471 T915 T920 arg1Of patients,(
R472 T918 T916 arg2Of U.S.,in
R473 T918 T917 arg1Of U.S.,the
R475 T921 T922 arg1Of Friedman,et
R476 T921 T923 arg1Of Friedman,al.
R477 T921 T924 arg1Of Friedman,","
R478 T921 T926 arg1Of Friedman,;
R479 T921 T932 arg1Of Friedman,;
R480 T925 T924 arg2Of 2000,","
R481 T927 T926 arg2Of Stupp,;
R482 T927 T928 arg1Of Stupp,et
R483 T927 T929 arg1Of Stupp,al.
R484 T927 T930 arg1Of Stupp,","
R485 T931 T930 arg2Of 2009,","
R486 T933 T932 arg2Of Silber,;
R487 T933 T934 arg1Of Silber,et
R488 T933 T935 arg1Of Silber,al.
R489 T933 T936 arg1Of Silber,","
R490 T937 T936 arg2Of 2012,","
R492 T939 T940 arg1Of Glioblastoma,(
R493 T939 T943 arg1Of Glioblastoma,is
R494 T939 T945 arg1Of Glioblastoma,lethal
R495 T941 T940 arg2Of GBM,(
R496 T942 T940 arg3Of ),(
R497 T943 T947 arg1Of is,and
R498 T945 T943 arg2Of lethal,is
R499 T945 T944 arg1Of lethal,highly
R500 T947 T946 arg1Of and,","
R501 T947 T955 arg1Of and,and
R502 T951 T948 arg1Of expectancy,the
R503 T951 T949 arg1Of expectancy,average
R504 T951 T950 arg1Of expectancy,survival
R505 T951 T952 arg1Of expectancy,is
R506 T951 T953 arg1Of expectancy,14.6 months
R507 T952 T947 arg2Of is,and
R508 T953 T952 arg2Of 14.6 months,is
R509 T955 T954 arg1Of and,","
R510 T960 T956 arg1Of rate,the
R511 T960 T957 arg1Of rate,overall
R512 T960 T958 arg1Of rate,5-year
R513 T960 T959 arg1Of rate,survival
R514 T960 T961 arg1Of rate,for
R515 T960 T963 arg1Of rate,is
R516 T962 T961 arg2Of GBM,for
R517 T963 T955 arg2Of is,and
R518 T963 T967 arg1Of is,(
R519 T965 T964 arg1Of 9.8,only
R520 T966 T963 arg2Of %,is
R521 T966 T965 arg1Of %,9.8
R522 T968 T967 arg2Of Friedman,(
R523 T968 T969 arg1Of Friedman,et
R524 T968 T970 arg1Of Friedman,al.
R525 T968 T971 arg1Of Friedman,","
R526 T968 T973 arg1Of Friedman,;
R527 T972 T971 arg2Of 2000,","
R528 T974 T973 arg2Of Stupp,;
R529 T974 T975 arg1Of Stupp,et
R530 T974 T976 arg1Of Stupp,al.
R531 T974 T977 arg1Of Stupp,","
R532 T978 T977 arg2Of 2009,","
R533 T979 T967 arg3Of ),(
R534 T981 T980 arg1Of levels,High
R535 T981 T982 arg1Of levels,of
R536 T981 T991 arg1Of levels,are
R537 T981 T993 arg2Of levels,seen
R538 T983 T984 arg1Of resistance,to
R539 T983 T988 arg1Of resistance,and
R540 T987 T984 arg2Of modalities,to
R541 T987 T985 arg1Of modalities,current
R542 T987 T986 arg1Of modalities,therapeutic
R543 T988 T982 arg2Of and,of
R544 T990 T988 arg2Of relapse,and
R545 T990 T989 arg1Of relapse,cancer
R546 T993 T991 arg2Of seen,are
R547 T993 T992 arg1Of seen,frequently
R548 T993 T994 arg1Of seen,in
R549 T993 T996 arg1Of seen,(
R550 T995 T994 arg2Of patients,in
R551 T997 T996 arg2Of Haar,(
R552 T997 T998 arg1Of Haar,et
R553 T997 T999 arg1Of Haar,al.
R554 T997 T1000 arg1Of Haar,","
R555 T997 T1002 arg1Of Haar,;
R556 T1001 T1000 arg2Of 2012,","
R557 T1003 T1002 arg2Of Happold,;
R558 T1003 T1004 arg1Of Happold,et
R559 T1003 T1005 arg1Of Happold,al.
R560 T1003 T1006 arg1Of Happold,","
R561 T1007 T1006 arg2Of 2012,","
R562 T1008 T996 arg3Of ),(
R567 T1012 T1009 arg1Of therapy,The
R572 T1019 T1020 arg1Of surgery,","
R573 T1020 T1023 arg1Of ",",and
R574 T1021 T1020 arg2Of radiation,","
R575 T1023 T1016 arg2Of and,includes
R576 T1023 T1022 arg1Of and,","
R577 T1024 T1023 arg2Of treatment,and
R578 T1024 T1025 arg1Of treatment,with
R579 T1030 T1025 arg2Of temozolomide,with
R580 T1030 T1026 arg1Of temozolomide,the
R581 T1030 T1027 arg1Of temozolomide,monofunctional
R582 T1030 T1028 arg1Of temozolomide,alkylating
R583 T1030 T1029 arg1Of temozolomide,agent
R584 T1030 T1031 arg1Of temozolomide,(
R585 T1030 T1034 arg1Of temozolomide,(
R586 T1032 T1031 arg2Of TMZ,(
R587 T1033 T1031 arg3Of ),(
R588 T1035 T1034 arg2Of Friedman,(
R589 T1035 T1036 arg1Of Friedman,et
R590 T1035 T1037 arg1Of Friedman,al.
R591 T1035 T1038 arg1Of Friedman,","
R592 T1035 T1040 arg1Of Friedman,;
R593 T1039 T1038 arg2Of 2000,","
R594 T1041 T1040 arg2Of Nishikawa,;
R595 T1041 T1042 arg1Of Nishikawa,","
R596 T1043 T1042 arg2Of 2010,","
R597 T1044 T1034 arg3Of ),(
R598 T1046 T1045 arg1Of mechanisms,Multiple
R599 T1046 T1047 arg1Of mechanisms,are
R600 T1046 T1048 arg2Of mechanisms,involved
R601 T1048 T1047 arg2Of involved,are
R602 T1048 T1049 arg1Of involved,in
R603 T1052 T1049 arg2Of resistance,in
R604 T1052 T1050 arg1Of resistance,the
R605 T1052 T1051 arg1Of resistance,TMZ
R606 T1052 T1053 arg1Of resistance,","
R607 T1052 T1054 arg1Of resistance,which
R608 T1052 T1055 arg1Of resistance,may
R609 T1052 T1056 arg1Of resistance,include
R610 T1056 T1055 arg2Of include,may
R611 T1059 T1057 arg1Of cells,cancer
R612 T1059 T1058 arg1Of cells,stem
R613 T1059 T1060 arg1Of cells,","
R614 T1060 T1062 arg1Of ",",","
R615 T1061 T1060 arg2Of microRNAs,","
R616 T1062 T1065 arg1Of ",",","
R617 T1064 T1062 arg2Of efflux,","
R618 T1064 T1063 arg1Of efflux,drug
R619 T1065 T1069 arg1Of ",",","
R620 T1068 T1065 arg2Of repair,","
R621 T1068 T1066 arg1Of repair,DNA
R622 T1068 T1067 arg1Of repair,damage
R623 T1069 T1056 arg2Of ",",include
R624 T1069 T1072 arg1Of ",",under
R625 T1071 T1069 arg2Of cells,","
R626 T1071 T1070 arg1Of cells,tumor
R627 T1073 T1074 arg1Of hypoxia,","
R628 T1074 T1077 arg1Of ",",","
R629 T1076 T1074 arg2Of deacetylation,","
R630 T1076 T1075 arg1Of deacetylation,histone
R631 T1077 T1080 arg1Of ",",","
R632 T1079 T1077 arg2Of transition,","
R633 T1079 T1078 arg1Of transition,epithelial-mesenchymal
R634 T1080 T1084 arg1Of ",",and
R635 T1082 T1080 arg2Of kinase,","
R636 T1082 T1081 arg1Of kinase,STAT3
R637 T1084 T1072 arg2Of and,under
R638 T1084 T1083 arg1Of and,","
R639 T1086 T1084 arg2Of others,and
R640 T1086 T1085 arg1Of others,many
R641 T1086 T1087 arg1Of others,(
R642 T1088 T1087 arg2Of Haar,(
R643 T1088 T1089 arg1Of Haar,et
R644 T1088 T1090 arg1Of Haar,al.
R645 T1088 T1091 arg1Of Haar,","
R646 T1088 T1093 arg1Of Haar,;
R647 T1088 T1099 arg1Of Haar,;
R648 T1092 T1091 arg2Of 2012,","
R649 T1094 T1093 arg2Of Happold,;
R650 T1094 T1095 arg1Of Happold,et
R651 T1094 T1096 arg1Of Happold,al.
R652 T1094 T1097 arg1Of Happold,","
R653 T1098 T1097 arg2Of 2012,","
R654 T1100 T1101 arg1Of Johannessen,and
R655 T1101 T1099 arg2Of and,;
R656 T1101 T1103 arg1Of and,","
R657 T1101 T1105 arg1Of and,;
R658 T1101 T1111 arg1Of and,;
R659 T1102 T1101 arg2Of Bjerkvig,and
R660 T1104 T1103 arg2Of 2012,","
R661 T1106 T1105 arg2Of Kitange,;
R662 T1106 T1107 arg1Of Kitange,et
R663 T1106 T1108 arg1Of Kitange,al.
R664 T1106 T1109 arg1Of Kitange,","
R665 T1110 T1109 arg2Of 2012,","
R666 T1112 T1111 arg2Of Kohsaka,;
R667 T1112 T1113 arg1Of Kohsaka,et
R668 T1112 T1114 arg1Of Kohsaka,al.
R669 T1112 T1115 arg1Of Kohsaka,","
R670 T1112 T1117 arg1Of Kohsaka,;
R671 T1116 T1115 arg2Of 2012,","
R672 T1118 T1117 arg2Of Zhang,;
R673 T1118 T1119 arg1Of Zhang,et
R674 T1118 T1120 arg1Of Zhang,al.
R675 T1118 T1121 arg1Of Zhang,","
R676 T1122 T1121 arg2Of 2012b,","
R677 T1123 T1087 arg3Of ),(
R678 T1124 T1125 arg1Of Temozolomide,induces
R679 T1126 T1125 arg2Of generation,induces
R680 T1126 T1127 arg1Of generation,of
R681 T1129 T1127 arg2Of lesions,of
R682 T1129 T1128 arg1Of lesions,DNA
R683 T1129 T1130 arg1Of lesions,","
R684 T1129 T1131 arg1Of lesions,including
R685 T1132 T1133 arg1Of O6-methylguanine,","
R686 T1133 T1136 arg1Of ",",and
R687 T1134 T1133 arg2Of N3-methyladenine,","
R688 T1136 T1131 arg2Of and,including
R689 T1136 T1135 arg1Of and,","
R690 T1136 T1138 arg1Of and,(
R691 T1137 T1136 arg2Of N7-methylguanine,and
R692 T1139 T1138 arg2Of Goellner,(
R693 T1139 T1140 arg1Of Goellner,et
R694 T1139 T1141 arg1Of Goellner,al.
R695 T1139 T1142 arg1Of Goellner,","
R696 T1139 T1144 arg1Of Goellner,;
R697 T1143 T1142 arg2Of 2011,","
R698 T1145 T1144 arg2Of Zhang,;
R699 T1145 T1146 arg1Of Zhang,et
R700 T1145 T1147 arg1Of Zhang,al.
R701 T1145 T1148 arg1Of Zhang,","
R702 T1149 T1148 arg2Of 2012b,","
R703 T1150 T1138 arg3Of ),(
R704 T1153 T1151 arg1Of lesion,The
R705 T1153 T1152 arg1Of lesion,O6-methylguanine
R706 T1153 T1154 arg1Of lesion,is
R707 T1153 T1155 arg2Of lesion,known
R708 T1153 T1157 arg1Of lesion,trigger
R709 T1155 T1154 arg2Of known,is
R710 T1157 T1155 arg3Of trigger,known
R711 T1157 T1156 arg1Of trigger,to
R712 T1157 T1163 arg1Of trigger,","
R713 T1157 T1164 modOf trigger,to
R714 T1157 T1168 arg1Of trigger,(
R715 T1158 T1161 arg1Of autophagy,than
R716 T1161 T1157 arg2Of than,trigger
R717 T1161 T1159 arg1Of than,","
R718 T1161 T1160 arg1Of than,rather
R719 T1162 T1161 arg2Of apoptosis,than
R720 T1165 T1164 arg1Of cause,to
R721 T1167 T1165 arg2Of death,cause
R722 T1167 T1166 arg1Of death,cell
R723 T1169 T1168 arg2Of Kanzawa,(
R724 T1169 T1170 arg1Of Kanzawa,et
R725 T1169 T1171 arg1Of Kanzawa,al.
R726 T1169 T1172 arg1Of Kanzawa,","
R727 T1173 T1172 arg2Of 2003,","
R728 T1174 T1168 arg3Of ),(
R729 T1177 T1178 arg1Of inhibition,of
R730 T1177 T1181 arg1Of inhibition,by
R731 T1177 T1189 arg1Of inhibition,leads
R732 T1177 T1196 arg1Of inhibition,enhances
R733 T1180 T1178 arg2Of Bcl-2,of
R734 T1180 T1179 arg1Of Bcl-2,antiapoptotic
R735 T1184 T1182 arg1Of inhibitor,a
R736 T1184 T1183 arg1Of inhibitor,pan-Bcl-2
R737 T1186 T1184 arg1Of −,inhibitor
R738 T1186 T1185 arg1Of −,(
R739 T1186 T1187 arg1Of −,)
R740 T1188 T1181 arg2Of -gossypol,by
R741 T1188 T1186 arg1Of -gossypol,−
R742 T1189 T1190 arg1Of leads,to
R743 T1189 T1195 arg1Of leads,and
R744 T1192 T1190 arg2Of death,to
R745 T1192 T1191 arg1Of death,autophagic
R746 T1192 T1193 arg1Of death,in
R747 T1194 T1193 arg2Of gliomas,in
R748 T1195 T1175 arg1Of and,Also
R749 T1195 T1176 arg1Of and,","
R750 T1196 T1195 arg2Of enhances,and
R751 T1196 T1201 arg1Of enhances,(
R752 T1198 T1196 arg2Of action,enhances
R753 T1198 T1197 arg1Of action,the
R754 T1198 T1199 arg1Of action,of
R755 T1200 T1199 arg2Of TMZ,of
R756 T1202 T1201 arg2Of Voss,(
R757 T1202 T1203 arg1Of Voss,et
R758 T1202 T1204 arg1Of Voss,al.
R759 T1202 T1205 arg1Of Voss,","
R760 T1206 T1205 arg2Of 2010,","
R761 T1207 T1201 arg3Of ),(
R762 T1212 T1210 arg1Of study,a
R763 T1212 T1211 arg1Of study,recent
R764 T1212 T1213 arg1Of study,demonstrated
R765 T1213 T1208 arg1Of demonstrated,However
R766 T1213 T1209 arg1Of demonstrated,","
R767 T1216 T1215 arg1Of autophagy,TMZ-induced
R768 T1216 T1217 arg1Of autophagy,is
R769 T1216 T1218 arg1Of autophagy,pro-survival
R770 T1216 T1221 arg1Of autophagy,may
R771 T1216 T1222 arg1Of autophagy,block
R772 T1217 T1220 arg1Of is,and
R773 T1218 T1217 arg2Of pro-survival,is
R774 T1220 T1213 arg2Of and,demonstrated
R775 T1220 T1214 arg1Of and,that
R776 T1220 T1219 arg1Of and,","
R777 T1222 T1220 arg2Of block,and
R778 T1222 T1221 arg2Of block,may
R779 T1222 T1229 arg1Of block,(
R780 T1225 T1222 arg2Of apoptosis,block
R781 T1225 T1223 arg1Of apoptosis,the
R782 T1225 T1224 arg1Of apoptosis,eventual
R783 T1225 T1226 arg1Of apoptosis,in
R784 T1228 T1226 arg2Of cells,in
R785 T1228 T1227 arg1Of cells,GBM
R786 T1230 T1229 arg2Of Knizhnik,(
R787 T1230 T1231 arg1Of Knizhnik,et
R788 T1230 T1232 arg1Of Knizhnik,al.
R789 T1230 T1233 arg1Of Knizhnik,","
R790 T1234 T1233 arg2Of 2013,","
R791 T1235 T1229 arg3Of ),(
R792 T1240 T1239 arg2Of C1orf201,(
R793 T1241 T1239 arg3Of ),(
R794 T1242 T1238 arg1Of gene,MAPO2
R795 T1242 T1239 arg1Of gene,(
R796 T1242 T1243 arg1Of gene,participates
R797 T1243 T1236 arg1Of participates,Also
R798 T1243 T1237 arg1Of participates,","
R799 T1243 T1244 arg1Of participates,in
R800 T1243 T1249 arg1Of participates,(
R801 T1248 T1244 arg2Of apoptosis,in
R802 T1248 T1245 arg1Of apoptosis,the
R803 T1248 T1246 arg1Of apoptosis,O6-methylguanine
R804 T1248 T1247 arg1Of apoptosis,lesion-induced
R805 T1250 T1249 arg2Of Fujikane,(
R806 T1250 T1251 arg1Of Fujikane,et
R807 T1250 T1252 arg1Of Fujikane,al.
R808 T1250 T1253 arg1Of Fujikane,","
R809 T1254 T1253 arg2Of 2012,","
R810 T1255 T1249 arg3Of ),(
R811 T1257 T1256 arg1Of gene,MAPO2
R812 T1257 T1258 arg1Of gene,encodes
R813 T1262 T1258 arg2Of protein,encodes
R814 T1262 T1259 arg1Of protein,a
R815 T1262 T1260 arg1Of protein,novel
R816 T1262 T1261 arg1Of protein,37-kDa
R817 T1263 T1264 arg1Of It,is
R818 T1263 T1266 arg2Of It,determined
R819 T1266 T1264 arg2Of determined,is
R820 T1266 T1265 arg1Of determined,not
R821 T1266 T1267 arg1Of determined,whether
R822 T1269 T1268 arg1Of gene,this
R823 T1269 T1270 arg1Of gene,is
R824 T1269 T1271 arg2Of gene,involved
R825 T1271 T1267 arg2Of involved,whether
R826 T1271 T1270 arg2Of involved,is
R827 T1271 T1272 arg1Of involved,in
R828 T1273 T1272 arg2Of autophagy,in
R829 T1276 T1274 arg1Of lesion,The
R830 T1276 T1275 arg1Of lesion,O6-methylguanine
R831 T1276 T1277 arg1Of lesion,is
R832 T1277 T1289 arg1Of is,(
R833 T1279 T1277 arg2Of substrate,is
R834 T1279 T1278 arg1Of substrate,a
R835 T1279 T1280 arg1Of substrate,for
R836 T1279 T1283 arg1Of substrate,by
R837 T1282 T1280 arg2Of repair,for
R838 T1282 T1281 arg1Of repair,direct
R839 T1285 T1283 arg2Of methyltransferase,by
R840 T1285 T1284 arg1Of methyltransferase,O6-methylguanine-DNA
R841 T1285 T1286 arg1Of methyltransferase,(
R842 T1287 T1286 arg2Of MGMT,(
R843 T1288 T1286 arg3Of ),(
R844 T1290 T1289 arg2Of Pollack,(
R845 T1290 T1291 arg1Of Pollack,et
R846 T1290 T1292 arg1Of Pollack,al.
R847 T1290 T1293 arg1Of Pollack,","
R848 T1290 T1295 arg1Of Pollack,;
R849 T1290 T1301 arg1Of Pollack,;
R850 T1294 T1293 arg2Of 2006,","
R851 T1296 T1295 arg2Of Hegi,;
R852 T1296 T1297 arg1Of Hegi,et
R853 T1296 T1298 arg1Of Hegi,al.
R854 T1296 T1299 arg1Of Hegi,","
R855 T1300 T1299 arg2Of 2008,","
R856 T1302 T1301 arg2Of Fukushima,;
R857 T1302 T1303 arg1Of Fukushima,et
R858 T1302 T1304 arg1Of Fukushima,al.
R859 T1302 T1305 arg1Of Fukushima,","
R860 T1302 T1307 arg1Of Fukushima,;
R861 T1306 T1305 arg2Of 2009,","
R862 T1308 T1307 arg2Of Zhang,;
R863 T1308 T1309 arg1Of Zhang,et
R864 T1308 T1310 arg1Of Zhang,al.
R865 T1308 T1311 arg1Of Zhang,","
R866 T1312 T1311 arg2Of 2012b,","
R867 T1313 T1289 arg3Of ),(
R868 T1316 T1314 arg2Of repair,Without
R869 T1316 T1315 arg1Of repair,MGMT
R870 T1318 T1319 arg1Of O6-methylguanine,initiates
R871 T1319 T1314 arg1Of initiates,Without
R872 T1319 T1317 arg1Of initiates,","
R873 T1320 T1321 arg1Of activation,of
R874 T1320 T1328 arg1Of activation,or
R875 T1325 T1324 arg2Of MMR,(
R876 T1326 T1324 arg3Of ),(
R877 T1327 T1321 arg2Of proteins,of
R878 T1327 T1322 arg1Of proteins,mismatch
R879 T1327 T1323 arg1Of proteins,repair-deficient
R880 T1327 T1324 arg1Of proteins,(
R881 T1328 T1319 arg2Of or,initiates
R882 T1331 T1328 arg2Of kinase,or
R883 T1331 T1329 arg1Of kinase,Rad3-related
R884 T1331 T1330 arg1Of kinase,protein
R885 T1331 T1332 arg1Of kinase,that
R886 T1331 T1334 arg1Of kinase,leads
R887 T1334 T1333 arg1Of leads,ultimately
R888 T1334 T1335 arg1Of leads,to
R889 T1334 T1339 arg1Of leads,(
R890 T1338 T1335 arg2Of death,to
R891 T1338 T1336 arg1Of death,apoptotic
R892 T1338 T1337 arg1Of death,cell
R893 T1340 T1339 arg2Of Caporali,(
R894 T1340 T1341 arg1Of Caporali,et
R895 T1340 T1342 arg1Of Caporali,al.
R896 T1340 T1343 arg1Of Caporali,","
R897 T1340 T1345 arg1Of Caporali,;
R898 T1340 T1351 arg1Of Caporali,;
R899 T1344 T1343 arg2Of 2004,","
R900 T1346 T1347 arg1Of Wang,and
R901 T1347 T1345 arg2Of and,;
R902 T1347 T1349 arg1Of and,","
R903 T1348 T1347 arg2Of Edelmann,and
R904 T1350 T1349 arg2Of 2006,","
R905 T1352 T1351 arg2Of Roos,;
R906 T1352 T1353 arg1Of Roos,et
R907 T1352 T1354 arg1Of Roos,al.
R908 T1352 T1355 arg1Of Roos,","
R909 T1356 T1355 arg2Of 2007,","
R910 T1357 T1339 arg3Of ),(
R911 T1359 T1358 arg1Of expression,High
R912 T1359 T1360 arg1Of expression,of
R913 T1359 T1366 arg1Of expression,contributes
R914 T1361 T1362 arg1Of MGMT,or
R915 T1362 T1360 arg2Of or,of
R916 T1363 T1362 arg2Of loss,or
R917 T1363 T1364 arg1Of loss,of
R918 T1365 T1364 arg2Of MMR,of
R919 T1366 T1367 arg1Of contributes,significantly
R920 T1366 T1368 arg1Of contributes,to
R921 T1366 T1371 arg1Of contributes,in
R922 T1366 T1375 arg1Of contributes,(
R923 T1370 T1368 arg2Of resistance,to
R924 T1370 T1369 arg1Of resistance,TMZ
R925 T1374 T1371 arg2Of cases,in
R926 T1374 T1372 arg1Of cases,many
R927 T1374 T1373 arg1Of cases,clinical
R928 T1376 T1375 arg2Of Pollack,(
R929 T1376 T1377 arg1Of Pollack,et
R930 T1376 T1378 arg1Of Pollack,al.
R931 T1376 T1379 arg1Of Pollack,","
R932 T1376 T1381 arg1Of Pollack,;
R933 T1376 T1387 arg1Of Pollack,;
R934 T1380 T1379 arg2Of 2006,","
R935 T1382 T1381 arg2Of Hegi,;
R936 T1382 T1383 arg1Of Hegi,et
R937 T1382 T1384 arg1Of Hegi,al.
R938 T1382 T1385 arg1Of Hegi,","
R939 T1386 T1385 arg2Of 2008,","
R940 T1388 T1387 arg2Of Sarkaria,;
R941 T1388 T1389 arg1Of Sarkaria,et
R942 T1388 T1390 arg1Of Sarkaria,al.
R943 T1388 T1391 arg1Of Sarkaria,","
R944 T1392 T1391 arg2Of 2008,","
R945 T1393 T1375 arg3Of ),(
R946 T1395 T1394 arg1Of initiation,The
R947 T1395 T1396 arg1Of initiation,of
R948 T1395 T1399 arg1Of initiation,fails
R949 T1398 T1396 arg2Of signaling,of
R950 T1398 T1397 arg1Of signaling,apoptotic
R951 T1399 T1400 arg1Of fails,in
R952 T1400 T1401 arg1Of in,the
R953 T1400 T1403 arg1Of in,of
R954 T1402 T1400 arg2Of absence,in
R955 T1406 T1400 arg3Of system,in
R956 T1406 T1404 arg1Of system,the
R957 T1406 T1405 arg1Of system,MMR
R958 T1407 T1408 arg1Of Sensitivity,to
R959 T1407 T1410 arg1Of Sensitivity,is
R960 T1407 T1412 arg2Of Sensitivity,associated
R961 T1409 T1408 arg2Of TMZ,to
R962 T1412 T1410 arg2Of associated,is
R963 T1412 T1411 arg1Of associated,significantly
R964 T1412 T1413 arg1Of associated,with
R965 T1416 T1413 arg2Of status,with
R966 T1416 T1414 arg1Of status,the
R967 T1416 T1415 arg1Of status,methylation
R968 T1416 T1417 arg1Of status,of
R969 T1420 T1417 arg2Of promoter,of
R970 T1420 T1418 arg1Of promoter,MGMT
R971 T1420 T1419 arg1Of promoter,gene
R972 T1420 T1421 arg1Of promoter,in
R973 T1422 T1421 arg2Of cells,in
R974 T1422 T1423 arg2Of cells,committed
R975 T1423 T1424 arg1Of committed,to
R976 T1425 T1424 arg2Of differentiation,to
R977 T1425 T1426 arg1Of differentiation,(
R978 T1429 T1426 arg2Of al.,(
R979 T1429 T1427 arg1Of al.,Villalva
R980 T1429 T1428 arg1Of al.,et
R981 T1429 T1430 arg1Of al.,","
R982 T1431 T1430 arg2Of 2012,","
R983 T1432 T1426 arg3Of ),(
R984 T1434 T1433 arg1Of increase,An
R985 T1434 T1435 arg1Of increase,in
R986 T1434 T1440 arg1Of increase,","
R987 T1434 T1441 arg1Of increase,which
R988 T1434 T1442 arg1Of increase,blocks
R989 T1434 T1447 arg1Of increase,prolongs
R990 T1439 T1435 arg2Of methylation,in
R991 T1439 T1436 arg1Of methylation,MGMT
R992 T1439 T1437 arg1Of methylation,gene
R993 T1439 T1438 arg1Of methylation,promoter
R994 T1445 T1442 arg2Of expression,blocks
R995 T1445 T1443 arg1Of expression,MGMT
R996 T1445 T1444 arg1Of expression,protein
R997 T1447 T1446 arg1Of prolongs,","
R998 T1450 T1447 arg2Of survival,prolongs
R999 T1450 T1448 arg1Of survival,cancer
R1000 T1450 T1449 arg1Of survival,patient
R1001 T1454 T1453 arg2Of microRNA-21,overexpressed
R1002 T1454 T1455 arg1Of microRNA-21,reduces
R1003 T1455 T1451 arg1Of reduces,Intriguingly
R1004 T1455 T1452 arg1Of reduces,","
R1005 T1455 T1461 arg1Of reduces,","
R1006 T1455 T1463 modOf reduces,blocking
R1007 T1457 T1456 arg1Of ratio,Bax/Bcl-2
R1008 T1457 T1458 arg1Of ratio,and
R1009 T1458 T1455 arg2Of and,reduces
R1010 T1460 T1458 arg2Of activity,and
R1011 T1460 T1459 arg1Of activity,caspase-3
R1012 T1463 T1462 arg1Of blocking,thereby
R1013 T1465 T1463 arg2Of apoptosis,blocking
R1014 T1465 T1464 arg1Of apoptosis,TMZ-induced
R1015 T1465 T1466 arg1Of apoptosis,(
R1016 T1467 T1466 arg2Of Shi,(
R1017 T1467 T1468 arg1Of Shi,et
R1018 T1467 T1469 arg1Of Shi,al.
R1019 T1467 T1470 arg1Of Shi,","
R1020 T1471 T1470 arg2Of 2010,","
R1021 T1472 T1466 arg3Of ),(
R1022 T1473 T1474 arg1Of MicroRNA-21,is
R1023 T1473 T1475 arg2Of MicroRNA-21,considered
R1024 T1475 T1474 arg2Of considered,is
R1025 T1475 T1476 arg1Of considered,as
R1026 T1479 T1476 arg2Of factor,as
R1027 T1479 T1477 arg1Of factor,a
R1028 T1479 T1478 arg1Of factor,pro-survival
R1029 T1479 T1480 arg1Of factor,for
R1030 T1482 T1480 arg2Of cells,for
R1031 T1482 T1481 arg1Of cells,cancer
R1032 T1482 T1483 arg1Of cells,(
R1033 T1484 T1483 arg2Of Li,(
R1034 T1484 T1485 arg1Of Li,et
R1035 T1484 T1486 arg1Of Li,al.
R1036 T1484 T1487 arg1Of Li,","
R1037 T1488 T1487 arg2Of 2012,","
R1038 T1489 T1483 arg3Of ),(
R1039 T1490 T1491 arg1Of Integrins,play
R1040 T1491 T1494 arg1Of play,in
R1041 T1491 T1502 arg1Of play,and
R1042 T1493 T1491 arg2Of role,play
R1043 T1493 T1492 arg1Of role,a
R1044 T1496 T1494 arg2Of resistance,in
R1045 T1496 T1495 arg1Of resistance,the
R1046 T1496 T1497 arg1Of resistance,of
R1047 T1496 T1500 arg1Of resistance,to
R1048 T1499 T1497 arg2Of cancers,of
R1049 T1499 T1498 arg1Of cancers,advanced
R1050 T1501 T1500 arg2Of radiotherapy,to
R1051 T1502 T1511 arg1Of and,and
R1052 T1505 T1503 arg1Of integrin,chemotherapy.
R1053 T1505 T1504 arg1Of integrin,α5β1
R1054 T1505 T1507 arg1Of integrin,regulates
R1055 T1507 T1502 arg2Of regulates,and
R1056 T1507 T1506 arg1Of regulates,negatively
R1057 T1509 T1507 arg2Of signaling,regulates
R1058 T1509 T1508 arg1Of signaling,p53
R1059 T1511 T1510 arg1Of and,","
R1060 T1513 T1512 arg1Of event,the
R1061 T1513 T1514 arg1Of event,induces
R1062 T1514 T1511 arg2Of induces,and
R1063 T1517 T1514 arg2Of resistance,induces
R1064 T1517 T1515 arg1Of resistance,glioma
R1065 T1517 T1516 arg1Of resistance,cell
R1066 T1517 T1518 arg1Of resistance,to
R1067 T1519 T1518 arg2Of TMZ,to
R1068 T1519 T1520 arg1Of TMZ,(
R1069 T1519 T1529 modOf TMZ,ri
R1070 T1521 T1520 arg2Of Janouskova,(
R1071 T1521 T1522 arg1Of Janouskova,et
R1072 T1521 T1523 arg1Of Janouskova,al.
R1073 T1521 T1524 arg1Of Janouskova,","
R1074 T1525 T1524 arg2Of 2012,","
R1075 T1526 T1520 arg3Of ),(
R1076 T1528 T1527 arg1Of β1 integ,. α5
R1077 T1528 T1529 arg1Of β1 integ,ri
R1078 T1528 T1530 arg2Of β1 integ,n is consi
R1079 T1530 T1529 arg2Of n is consi,ri
R1080 T1530 T1531 arg1Of n is consi,de
R1081 T1534 T1531 arg2Of rapeut,de
R1082 T1534 T1532 arg1Of rapeut,r
R1083 T1534 T1533 arg1Of rapeut,ed as a the
R1084 T1534 T1535 arg1Of rapeut,ic
R1085 T1538 T1535 arg2Of grade ,ic
R1086 T1538 T1536 arg1Of grade ,target for
R1087 T1538 T1537 arg1Of grade ,high-
R1088 T1544 T1539 arg1Of alkylpurine-DNA-N-glycosylase,The
R1089 T1544 T1540 arg1Of alkylpurine-DNA-N-glycosylase,base
R1090 T1544 T1541 arg1Of alkylpurine-DNA-N-glycosylase,excision
R1091 T1544 T1542 arg1Of alkylpurine-DNA-N-glycosylase,repair
R1092 T1544 T1543 arg1Of alkylpurine-DNA-N-glycosylase,enzyme
R1093 T1544 T1545 arg1Of alkylpurine-DNA-N-glycosylase,(
R1094 T1544 T1548 arg1Of alkylpurine-DNA-N-glycosylase,","
R1095 T1544 T1549 arg1Of alkylpurine-DNA-N-glycosylase,which
R1096 T1544 T1550 arg1Of alkylpurine-DNA-N-glycosylase,repairs
R1097 T1544 T1559 arg1Of alkylpurine-DNA-N-glycosylase,participates
R1098 T1546 T1545 arg2Of APNG,(
R1099 T1547 T1545 arg3Of ),(
R1100 T1554 T1555 arg1Of N3-methyladenine,and
R1101 T1555 T1550 arg2Of and,repairs
R1102 T1555 T1551 arg1Of and,the
R1103 T1555 T1552 arg1Of and,cytotoxic
R1104 T1555 T1553 arg1Of and,lesions
R1105 T1556 T1555 arg2Of N7-methylguanine,and
R1106 T1559 T1557 arg1Of participates,","
R1107 T1559 T1558 arg1Of participates,also
R1108 T1559 T1560 arg1Of participates,in
R1109 T1559 T1564 arg1Of participates,(
R1110 T1563 T1560 arg2Of resistance,in
R1111 T1563 T1561 arg1Of resistance,the
R1112 T1563 T1562 arg1Of resistance,TMZ
R1113 T1565 T1564 arg2Of Agnihotri,(
R1114 T1565 T1566 arg1Of Agnihotri,et
R1115 T1565 T1567 arg1Of Agnihotri,al.
R1116 T1565 T1568 arg1Of Agnihotri,","
R1117 T1569 T1568 arg2Of 2012,","
R1118 T1570 T1564 arg3Of ),(
R1119 T1571 T1572 arg1Of Upregulation,of
R1120 T1571 T1577 modOf Upregulation,to
R1121 T1571 T1593 arg1Of Upregulation,contributes
R1122 T1576 T1572 arg2Of coupling,of
R1123 T1576 T1573 arg1Of coupling,mitochondrial
R1124 T1576 T1574 arg1Of coupling,respiratory
R1125 T1576 T1575 arg1Of coupling,chain
R1126 T1578 T1577 arg1Of suppress,to
R1127 T1580 T1578 arg2Of production,suppress
R1128 T1580 T1579 arg1Of production,the
R1129 T1580 T1581 arg1Of production,of
R1130 T1584 T1581 arg2Of species,of
R1131 T1584 T1582 arg1Of species,reactive
R1132 T1584 T1583 arg1Of species,oxygen
R1133 T1584 T1585 arg1Of species,(
R1134 T1584 T1588 arg2Of species,regulated
R1135 T1586 T1585 arg2Of ROS,(
R1136 T1587 T1585 arg3Of ),(
R1137 T1592 T1588 arg1Of oxidase,regulated
R1138 T1592 T1589 arg2Of oxidase,by
R1139 T1592 T1590 arg1Of oxidase,cytochrome
R1140 T1592 T1591 arg1Of oxidase,c
R1141 T1593 T1594 arg1Of contributes,in
R1142 T1593 T1596 arg1Of contributes,to
R1143 T1595 T1594 arg2Of part,in
R1144 T1598 T1596 arg2Of resistance,to
R1145 T1598 T1597 arg1Of resistance,TMZ
R1146 T1598 T1599 arg1Of resistance,in
R1147 T1600 T1599 arg2Of gliomas,in
R1148 T1600 T1601 arg1Of gliomas,(
R1149 T1602 T1601 arg2Of Oliva,(
R1150 T1602 T1603 arg1Of Oliva,et
R1151 T1602 T1604 arg1Of Oliva,al.
R1152 T1602 T1605 arg1Of Oliva,","
R1153 T1606 T1605 arg2Of 2011,","
R1154 T1607 T1601 arg3Of ),(
R1155 T1608 T1609 arg1Of Reversal,of
R1156 T1608 T1612 arg1Of Reversal,may
R1157 T1608 T1613 arg1Of Reversal,be
R1158 T1608 T1614 arg2Of Reversal,achieved
R1159 T1611 T1609 arg2Of resistance,of
R1160 T1611 T1610 arg1Of resistance,TMZ
R1161 T1614 T1612 arg2Of achieved,may
R1162 T1614 T1613 arg2Of achieved,be
R1163 T1617 T1614 arg1Of pseudosubstrates,achieved
R1164 T1617 T1615 arg2Of pseudosubstrates,by
R1165 T1617 T1616 arg1Of pseudosubstrates,MGMT
R1166 T1617 T1618 arg1Of pseudosubstrates,","
R1167 T1619 T1620 arg1Of O6-benzylguanine,and
R1168 T1620 T1618 arg2Of and,","
R1169 T1620 T1622 modOf and,to
R1170 T1621 T1620 arg2Of lomeguatrib,and
R1171 T1623 T1622 arg1Of sensitize,to
R1172 T1624 T1623 arg2Of tumors,sensitize
R1173 T1624 T1625 arg1Of tumors,to
R1174 T1626 T1625 arg2Of TMZ,to
R1175 T1626 T1627 arg1Of TMZ,(
R1176 T1628 T1627 arg2Of Zhang,(
R1177 T1628 T1629 arg1Of Zhang,et
R1178 T1628 T1630 arg1Of Zhang,al.
R1179 T1628 T1631 arg1Of Zhang,","
R1180 T1632 T1631 arg2Of 2012b,","
R1181 T1633 T1627 arg3Of ),(
R1182 T1634 T1635 arg1Of Methoxyamine-blocker,of
R1183 T1634 T1639 arg1Of Methoxyamine-blocker,contributes
R1184 T1638 T1635 arg2Of repair,of
R1185 T1638 T1636 arg1Of repair,base
R1186 T1638 T1637 arg1Of repair,excision
R1187 T1639 T1640 arg1Of contributes,significantly
R1188 T1639 T1641 arg1Of contributes,to
R1189 T1639 T1645 arg1Of contributes,when
R1190 T1643 T1641 arg2Of cytotoxicity,to
R1191 T1643 T1642 arg1Of cytotoxicity,TMZ
R1192 T1645 T1644 arg1Of when,particularly
R1193 T1647 T1646 arg1Of adducts,O6-methylguanine
R1194 T1647 T1648 arg1Of adducts,are
R1195 T1647 T1649 arg2Of adducts,repaired
R1196 T1647 T1651 arg2Of adducts,tolerated
R1197 T1649 T1650 arg1Of repaired,or
R1198 T1650 T1645 arg2Of or,when
R1199 T1650 T1648 arg2Of or,are
R1200 T1650 T1652 arg1Of or,(
R1201 T1651 T1650 arg2Of tolerated,or
R1202 T1653 T1652 arg2Of Goellner,(
R1203 T1653 T1654 arg1Of Goellner,et
R1204 T1653 T1655 arg1Of Goellner,al.
R1205 T1653 T1656 arg1Of Goellner,","
R1206 T1653 T1658 arg1Of Goellner,;
R1207 T1657 T1656 arg2Of 2011,","
R1208 T1659 T1658 arg2Of Zhang,;
R1209 T1659 T1660 arg1Of Zhang,et
R1210 T1659 T1661 arg1Of Zhang,al.
R1211 T1659 T1662 arg1Of Zhang,","
R1212 T1663 T1662 arg2Of 2012b,","
R1213 T1664 T1652 arg3Of ),(
R1214 T1666 T1665 arg1Of targeting,Dual
R1215 T1666 T1667 arg1Of targeting,of
R1216 T1670 T1668 arg1Of repair,base
R1217 T1670 T1669 arg1Of repair,excision
R1218 T1670 T1671 arg1Of repair,and
R1219 T1671 T1667 arg2Of and,of
R1220 T1672 T1671 arg2Of NAD,and
R1221 T1672 T1673 arg1Of NAD,(
R1222 T1674 T1673 arg2Of +,(
R1223 T1675 T1673 arg3Of ),(
R1224 T1676 T1666 arg1Of biosynthesis,targeting
R1225 T1676 T1677 arg1Of biosynthesis,may
R1226 T1676 T1678 arg1Of biosynthesis,reverse
R1227 T1678 T1677 arg2Of reverse,may
R1228 T1680 T1678 arg2Of resistance,reverse
R1229 T1680 T1679 arg1Of resistance,TMZ
R1230 T1680 T1681 arg1Of resistance,in
R1231 T1680 T1683 arg1Of resistance,with
R1232 T1682 T1681 arg2Of patients,in
R1233 T1684 T1685 arg1Of resistant,and
R1234 T1686 T1685 arg2Of recurrent,and
R1235 T1687 T1683 arg2Of GBM,with
R1236 T1687 T1684 arg1Of GBM,resistant
R1237 T1687 T1686 arg1Of GBM,recurrent
R1238 T1687 T1688 arg1Of GBM,(
R1239 T1689 T1688 arg2Of Goellner,(
R1240 T1689 T1690 arg1Of Goellner,et
R1241 T1689 T1691 arg1Of Goellner,al.
R1242 T1689 T1692 arg1Of Goellner,","
R1243 T1693 T1692 arg2Of 2011,","
R1244 T1694 T1688 arg3Of ),(
R1245 T1695 T1696 arg1Of Interferon-β,(
R1246 T1695 T1699 arg1Of Interferon-β,","
R1247 T1697 T1696 arg2Of IFN-β,(
R1248 T1698 T1696 arg3Of ),(
R1249 T1699 T1704 arg1Of ",",","
R1250 T1700 T1699 arg2Of levetiracetam,","
R1251 T1700 T1701 arg1Of levetiracetam,(
R1252 T1702 T1701 arg2Of LEV,(
R1253 T1703 T1701 arg3Of ),(
R1254 T1704 T1707 arg1Of ",",and
R1255 T1705 T1704 arg2Of resveratrol,","
R1256 T1707 T1706 arg1Of and,","
R1257 T1707 T1713 arg1Of and,increase
R1258 T1709 T1707 arg2Of acid,and
R1259 T1709 T1708 arg1Of acid,valproic
R1260 T1709 T1710 arg1Of acid,(
R1261 T1711 T1710 arg2Of VAP,(
R1262 T1712 T1710 arg3Of ),(
R1263 T1713 T1718 arg1Of increase,through
R1264 T1713 T1723 arg1Of increase,(
R1265 T1715 T1713 arg2Of sensitivity,increase
R1266 T1715 T1714 arg1Of sensitivity,the
R1267 T1715 T1716 arg1Of sensitivity,of
R1268 T1717 T1716 arg2Of TMZ,of
R1269 T1719 T1720 arg1Of MGMT-dependent,or
R1270 T1721 T1720 arg2Of -independent,or
R1271 T1722 T1718 arg2Of mechanisms,through
R1272 T1722 T1719 arg1Of mechanisms,MGMT-dependent
R1273 T1722 T1721 arg1Of mechanisms,-independent
R1274 T1724 T1723 arg2Of Nakada,(
R1275 T1724 T1725 arg1Of Nakada,et
R1276 T1724 T1726 arg1Of Nakada,al.
R1277 T1724 T1727 arg1Of Nakada,","
R1278 T1728 T1727 arg2Of 2012,","
R1279 T1729 T1723 arg3Of ),(
R1280 T1730 T1731 arg1Of Resveratrol,","
R1281 T1730 T1736 arg1Of Resveratrol,reverses
R1282 T1734 T1731 arg2Of polyphenol,","
R1283 T1734 T1732 arg1Of polyphenol,a
R1284 T1734 T1733 arg1Of polyphenol,natural
R1285 T1736 T1735 arg1Of reverses,","
R1286 T1736 T1739 arg1Of reverses,via
R1287 T1736 T1743 arg1Of reverses,(
R1288 T1738 T1736 arg2Of resistance,reverses
R1289 T1738 T1737 arg1Of resistance,TMZ
R1290 T1742 T1739 arg2Of mechanism,via
R1291 T1742 T1740 arg1Of mechanism,an
R1292 T1742 T1741 arg1Of mechanism,NF-κB-dependent
R1293 T1744 T1743 arg2Of Huang,(
R1294 T1744 T1745 arg1Of Huang,et
R1295 T1744 T1746 arg1Of Huang,al.
R1296 T1744 T1747 arg1Of Huang,","
R1297 T1748 T1747 arg2Of 2012,","
R1298 T1749 T1743 arg3Of ),(
R1299 T1751 T1750 arg1Of inhibitor,STAT3
R1300 T1751 T1752 arg1Of inhibitor,or
R1301 T1752 T1755 arg1Of or,potentiates
R1302 T1754 T1752 arg2Of knockdown,or
R1303 T1754 T1753 arg1Of knockdown,STAT3
R1304 T1757 T1755 arg2Of efficacy,potentiates
R1305 T1757 T1756 arg1Of efficacy,TMZ
R1306 T1757 T1758 arg1Of efficacy,in
R1307 T1762 T1758 arg2Of lines,in
R1308 T1785 T1783 arg2Of resistance,of
R1309 T1785 T1784 arg1Of resistance,TMZ
R1310 T1787 T1786 arg2Of hyperoxia,Induced
R1311 T1787 T1788 arg1Of hyperoxia,can
R1312 T1787 T1789 arg1Of hyperoxia,be
R1313 T1787 T1790 arg2Of hyperoxia,utilized
R1314 T1762 T1759 arg1Of lines,resistant
R1315 T1762 T1760 arg1Of lines,GBM
R1316 T1790 T1788 arg2Of utilized,can
R1317 T1790 T1789 arg2Of utilized,be
R1318 T1762 T1761 arg1Of lines,cell
R1319 T1762 T1763 arg1Of lines,(
R1320 T1792 T1790 arg3Of reverse,utilized
R1321 T1792 T1791 arg1Of reverse,to
R1322 T1764 T1763 arg2Of Kohsaka,(
R1323 T1794 T1792 arg2Of resistance,reverse
R1324 T1794 T1793 arg1Of resistance,TMZ
R1325 T1794 T1795 arg1Of resistance,in
R1326 T1796 T1795 arg2Of GBMs,in
R1327 T1796 T1797 arg1Of GBMs,(
R1328 T1764 T1765 arg1Of Kohsaka,et
R1329 T1798 T1797 arg2Of Sun,(
R1330 T1798 T1799 arg1Of Sun,et
R1331 T1798 T1800 arg1Of Sun,al.
R1332 T1798 T1801 arg1Of Sun,","
R1333 T1764 T1766 arg1Of Kohsaka,al.
R1334 T1764 T1767 arg1Of Kohsaka,","
R1335 T1768 T1767 arg2Of 2012,","
R1336 T1802 T1801 arg2Of 2012,","
R1337 T1803 T1797 arg3Of ),(
R1338 T1806 T1804 arg1Of cells,Cancer
R1339 T1806 T1805 arg1Of cells,stem
R1340 T1806 T1807 arg1Of cells,are
R1341 T1807 T1808 arg1Of are,probably
R1342 T1769 T1763 arg3Of ),(
R1343 T1810 T1807 arg2Of key,are
R1344 T1810 T1809 arg1Of key,the
R1345 T1810 T1811 arg1Of key,to
R1346 T1810 T1813 arg1Of key,in
R1347 T1771 T1770 arg1Of hypoxia,Intratumoral
R1348 T1812 T1811 arg2Of failure,to
R1349 T1815 T1813 arg2Of treatment,in
R1350 T1815 T1814 arg1Of treatment,TMZ
R1351 T1817 T1816 arg1Of concept,The
R1352 T1817 T1818 arg1Of concept,of
R1353 T1817 T1823 arg1Of concept,from
R1354 T1817 T1831 arg1Of concept,has
R1355 T1817 T1832 arg1Of concept,been
R1356 T1817 T1834 arg2Of concept,complicated
R1357 T1817 T1837 arg2Of concept,thought
R1358 T1771 T1772 arg1Of hypoxia,is
R1359 T1771 T1773 arg1Of hypoxia,common
R1360 T1771 T1777 arg1Of hypoxia,may
R1361 T1771 T1778 arg1Of hypoxia,be
R1362 T1771 T1779 arg2Of hypoxia,associated
R1363 T1822 T1818 arg2Of survival,of
R1364 T1822 T1819 arg1Of survival,cancer
R1365 T1822 T1820 arg1Of survival,stem
R1366 T1822 T1821 arg1Of survival,cell
R1367 T1772 T1774 arg1Of is,in
R1368 T1824 T1823 arg2Of treatment,from
R1369 T1824 T1825 arg1Of treatment,with
R1370 T1826 T1827 arg1Of TMZ,and
R1371 T1772 T1776 arg1Of is,and
R1372 T1827 T1825 arg2Of and,with
R1373 T1773 T1772 arg2Of common,is
R1374 T1830 T1827 arg2Of drugs,and
R1375 T1830 T1828 arg1Of drugs,other
R1376 T1830 T1829 arg1Of drugs,chemotherapeutic
R1377 T1775 T1774 arg2Of GBMs,in
R1379 T1835 T1831 arg2Of than,has
R1380 T1835 T1832 arg2Of than,been
R1381 T1835 T1833 arg1Of than,more
R1382 T1779 T1776 arg2Of associated,and
R1383 T1837 T1835 arg2Of thought,than
R1384 T1837 T1836 arg1Of thought,previously
R1385 T1837 T1838 arg1Of thought,(
R1386 T1839 T1838 arg2Of Beier,(
R1387 T1839 T1840 arg1Of Beier,et
R1388 T1839 T1841 arg1Of Beier,al.
R1389 T1839 T1842 arg1Of Beier,","
R1390 T1839 T1844 arg1Of Beier,;
R1391 T1843 T1842 arg2Of 2011,","
R1392 T1779 T1777 arg2Of associated,may
R1393 T1779 T1778 arg2Of associated,be
R1394 T1845 T1844 arg2Of Chen,;
R1395 T1779 T1780 arg1Of associated,with
R1396 T1782 T1780 arg2Of development,with
R1397 T1845 T1846 arg1Of Chen,et
R1398 T1845 T1847 arg1Of Chen,al.
R1399 T1845 T1848 arg1Of Chen,","
R1400 T1849 T1848 arg2Of 2012,","
R1401 T1850 T1838 arg3Of ),(
R1402 T1782 T1781 arg1Of development,the
R1403 T1854 T1851 arg1Of cells,CD133-positive
R1404 T1854 T1852 arg1Of cells,cancer
R1405 T1854 T1853 arg1Of cells,stem
R1406 T1854 T1855 arg1Of cells,are
R1407 T1854 T1856 arg2Of cells,expressed
R1408 T1856 T1855 arg2Of expressed,are
R1409 T1856 T1857 arg1Of expressed,in
R1410 T1856 T1866 arg1Of expressed,(
R1411 T1782 T1783 arg1Of development,of
R1412 T1886 T1882 arg2Of cells,for
R1413 T1861 T1859 arg1Of cells,normal
R1414 T1861 T1860 arg1Of cells,stem
R1415 T1861 T1862 arg1Of cells,and
R1416 T1862 T1857 arg2Of and,in
R1417 T1862 T1858 arg1Of and,both
R1418 T1865 T1862 arg2Of cells,and
R1419 T1865 T1863 arg1Of cells,cancer
R1420 T1865 T1864 arg1Of cells,stem
R1421 T1867 T1868 arg1Of Donovan,and
R1422 T1868 T1866 arg2Of and,(
R1423 T1868 T1870 arg1Of and,","
R1424 T1869 T1868 arg2Of Pilkington,and
R1425 T1871 T1870 arg2Of 2012,","
R1426 T1872 T1866 arg3Of ),(
R1427 T1886 T1883 arg1Of cells,glioma
R1428 T1886 T1884 arg1Of cells,cancer
R1429 T1886 T1885 arg1Of cells,stem
R1430 T1886 T1887 arg1Of cells,relative
R1431 T1876 T1875 arg1Of role,the
R1432 T1876 T1877 arg1Of role,of
R1433 T1876 T1879 arg1Of role,as
R1434 T1876 T1892 arg1Of role,has
R1435 T1876 T1895 arg1Of role,be
R1436 T1876 T1896 arg2Of role,established
R1437 T1878 T1877 arg2Of CD133,of
R1438 T1887 T1888 arg1Of relative,to
R1439 T1891 T1888 arg2Of function,to
R1440 T1881 T1879 arg2Of marker,as
R1441 T1881 T1880 arg1Of marker,a
R1442 T1881 T1882 arg1Of marker,for
R1443 T1891 T1889 arg1Of function,its
R1444 T1891 T1890 arg1Of function,biological
R1445 T1892 T1873 arg1Of has,However
R1446 T1892 T1874 arg1Of has,","
R1447 T1892 T1893 arg1Of has,yet
R1448 T1896 T1892 arg2Of established,has
R1449 T1896 T1894 arg1Of established,to
R1453 T1896 T1895 arg2Of established,be
R2748 T4151 T4152 arg1Of p53,and
R2749 T4152 T4149 arg1Of and,tumor
R2750 T4152 T4150 arg1Of and,suppressors
R2751 T4152 T4154 arg1Of and,were
R2752 T4152 T4155 arg2Of and,shown
R2753 T4152 T4157 arg1Of and,regulate
R2754 T4153 T4152 arg2Of WWOX,and
R2755 T4155 T4147 arg1Of shown,Recently
R2756 T4155 T4148 arg1Of shown,","
R2757 T4155 T4154 arg2Of shown,were
R2758 T4157 T4155 arg3Of regulate,shown
R2759 T4157 T4156 arg1Of regulate,to
R2760 T4157 T4163 arg1Of regulate,(
R2761 T4159 T4157 arg2Of apoptosis,regulate
R2762 T4159 T4158 arg1Of apoptosis,the
R2763 T4159 T4160 arg1Of apoptosis,of
R2764 T4162 T4160 arg2Of cells,of
R2765 T4162 T4161 arg1Of cells,glioblastoma
R2766 T4164 T4163 arg2Of Chiang,(
R2767 T4164 T4165 arg1Of Chiang,et
R2768 T4164 T4166 arg1Of Chiang,al.
R2769 T4164 T4167 arg1Of Chiang,","
R2770 T4168 T4167 arg2Of 2012,","
R2771 T4169 T4163 arg3Of ),(
R2772 T4172 T4170 arg1Of oxidoreductase,WW
R2773 T4172 T4171 arg1Of oxidoreductase,domain-containing
R2774 T4172 T4173 arg1Of oxidoreductase,","
R2775 T4172 T4174 arg2Of oxidoreductase,known
R2776 T4172 T4183 arg1Of oxidoreductase,is
R2777 T4172 T4184 arg2Of oxidoreductase,encoded
R2778 T4174 T4175 arg1Of known,as
R2779 T4176 T4177 arg1Of WWOX,","
R2780 T4177 T4180 arg1Of ",",or
R2781 T4178 T4177 arg2Of FOR,","
R2782 T4180 T4175 arg2Of or,as
R2783 T4180 T4179 arg1Of or,","
R2784 T4181 T4180 arg2Of WOX1,or
R2785 T4184 T4182 arg1Of encoded,","
R2786 T4184 T4183 arg2Of encoded,is
R2787 T4190 T4184 arg1Of gene,encoded
R2788 T4190 T4185 arg2Of gene,by
R2789 T4190 T4186 arg1Of gene,human
R2790 T4190 T4187 arg1Of gene,or
R2791 T4190 T4188 arg1Of gene,mouse
R2792 T4190 T4189 arg1Of gene,WWOX/Wwox
R2793 T4192 T4191 arg1Of gene,This
R2794 T4192 T4193 arg1Of gene,is
R2795 T4192 T4194 arg1Of gene,located
R2796 T4194 T4193 arg2Of located,is
R2797 T4194 T4195 arg1Of located,in
R2798 T4197 T4195 arg2Of 16q23.3–24.1,in
R2799 T4197 T4196 arg1Of 16q23.3–24.1,chromosome
R2800 T4197 T4198 arg1Of 16q23.3–24.1,","
R2801 T4200 T4198 arg2Of area,","
R2802 T4200 T4199 arg1Of area,an
R2803 T4200 T4201 arg2Of area,known
R2804 T4201 T4202 arg1Of known,as
R2805 T4207 T4202 arg2Of FRA16D,as
R2806 T4207 T4203 arg1Of FRA16D,the
R2807 T4207 T4204 arg1Of FRA16D,common
R2808 T4207 T4205 arg1Of FRA16D,fragile
R2809 T4207 T4206 arg1Of FRA16D,site
R2810 T4211 T4208 arg1Of protein,The
R2811 T4211 T4209 arg1Of protein,full-length
R2812 T4211 T4210 arg1Of protein,WWOX
R2813 T4211 T4212 arg1Of protein,is
R2814 T4211 T4213 arg2Of protein,composed
R2815 T4213 T4267 arg1Of composed,(
R2816 T4213 T4212 arg2Of composed,is
R2817 T4213 T4214 arg1Of composed,of
R2818 T4213 T4236 arg1Of composed,(
R2819 T4218 T4215 arg1Of domains,two
R2820 T4218 T4216 arg1Of domains,N-terminal
R2821 T4218 T4217 arg1Of domains,WW
R2822 T4218 T4219 arg1Of domains,","
R2823 T4218 T4230 arg1Of domains,and
R2824 T4226 T4225 arg2Of SDR,(
R2825 T4227 T4225 arg3Of ),(
R2826 T4228 T4219 arg2Of domain,","
R2827 T4228 T4220 arg1Of domain,a
R2828 T4228 T4221 arg1Of domain,C-terminal
R2829 T4228 T4222 arg1Of domain,short-chain
R2830 T4228 T4223 arg1Of domain,alcohol
R2831 T4228 T4224 arg1Of domain,dehydrogenase/reductase
R2832 T4228 T4225 arg1Of domain,(
R2833 T4230 T4214 arg2Of and,of
R2834 T4230 T4229 arg1Of and,","
R2835 T4235 T4230 arg2Of D3,and
R2836 T4235 T4231 arg1Of D3,a
R2837 T4235 T4232 arg1Of D3,proapoptotic
R2838 T4235 T4233 arg1Of D3,C-terminal
R2839 T4235 T4234 arg1Of D3,tail
R2840 T4237 T4238 arg1Of Chang,et
R2841 T4237 T4239 arg1Of Chang,al.
R2842 T4237 T4240 arg1Of Chang,","
R2843 T4240 T4242 arg1Of ",",","
R2844 T4241 T4240 arg2Of 2001,","
R2845 T4242 T4244 arg1Of ",",","
R2846 T4243 T4242 arg2Of 2007,","
R2847 T4244 T4246 arg1Of ",",;
R2848 T4245 T4244 arg2Of 2010,","
R2849 T4246 T4236 arg2Of ;,(
R2850 T4246 T4260 arg1Of ;,;
R2851 T4247 T4248 arg1Of Aqeilan,et
R2852 T4247 T4249 arg1Of Aqeilan,al.
R2853 T4247 T4250 arg1Of Aqeilan,","
R2854 T4250 T4252 arg1Of ",",","
R2855 T4251 T4250 arg2Of 2004,","
R2856 T4252 T4254 arg1Of ",",;
R2857 T4253 T4252 arg2Of 2007,","
R2858 T4254 T4246 arg2Of ;,;
R2859 T4255 T4256 arg1Of Hong,et
R2860 T4255 T4257 arg1Of Hong,al.
R2861 T4255 T4258 arg1Of Hong,","
R2862 T4258 T4254 arg2Of ",",;
R2863 T4259 T4258 arg2Of 2007,","
R2864 T4261 T4260 arg2Of Salah,;
R2865 T4261 T4262 arg1Of Salah,et
R2866 T4261 T4263 arg1Of Salah,al.
R2867 T4261 T4264 arg1Of Salah,","
R2868 T4265 T4264 arg2Of 2012,","
R2869 T4266 T4236 arg3Of ),(
R2870 T4268 T4267 arg2Of Figure,(
R2871 T4268 T4269 arg1Of Figure,1
R2872 T4270 T4267 arg3Of ),(
R2873 T4271 T4272 arg1Of WWOX,may
R2874 T4271 T4273 arg1Of WWOX,act
R2875 T4273 T4272 arg2Of act,may
R2876 T4273 T4274 arg1Of act,as
R2877 T4273 T4282 arg1Of act,","
R2878 T4273 T4283 arg1Of act,since
R2879 T4277 T4274 arg2Of receptor,as
R2880 T4277 T4275 arg1Of receptor,an
R2881 T4277 T4276 arg1Of receptor,alternative
R2882 T4277 T4278 arg1Of receptor,for
R2883 T4281 T4278 arg2Of hormones,for
R2884 T4281 T4279 arg1Of hormones,sex
R2885 T4281 T4280 arg1Of hormones,steroid
R2886 T4286 T4284 arg1Of domain,its
R2887 T4286 T4285 arg1Of domain,SDR
R2888 T4286 T4287 arg1Of domain,possesses
R2889 T4287 T4283 arg2Of possesses,since
R2890 T4290 T4287 arg2Of motif,possesses
R2891 T4290 T4288 arg1Of motif,an
R2892 T4290 T4289 arg1Of motif,NSYK
R2893 T4290 T4291 arg1Of motif,capable
R2894 T4291 T4292 arg1Of capable,of
R2895 T4293 T4292 arg2Of interacting,of
R2896 T4293 T4294 arg1Of interacting,with
R2897 T4293 T4298 arg1Of interacting,(
R2898 T4295 T4296 arg1Of androgen,and
R2899 T4296 T4294 arg2Of and,with
R2900 T4297 T4296 arg2Of estrogen,and
R2901 T4299 T4298 arg2Of Chang,(
R2902 T4299 T4300 arg1Of Chang,et
R2903 T4299 T4301 arg1Of Chang,al.
R2904 T4299 T4302 arg1Of Chang,","
R2905 T4299 T4304 arg1Of Chang,;
R2906 T4303 T4302 arg2Of 2005a,","
R2907 T4305 T4304 arg2Of Su,;
R2908 T4305 T4306 arg1Of Su,et
R2909 T4305 T4307 arg1Of Su,al.
R2910 T4305 T4308 arg1Of Su,","
R2911 T4309 T4308 arg2Of 2012,","
R2912 T4310 T4298 arg3Of ),(
R2913 T4311 T4312 arg1Of Expression,of
R2914 T4311 T4314 arg1Of Expression,is
R2915 T4311 T4316 arg2Of Expression,altered
R2916 T4311 T4318 arg2Of Expression,lost
R2917 T4313 T4312 arg2Of WWOX,of
R2918 T4316 T4317 arg1Of altered,or
R2919 T4317 T4314 arg2Of or,is
R2920 T4317 T4315 arg1Of or,either
R2921 T4318 T4317 arg2Of lost,or
R2922 T4318 T4319 arg1Of lost,from
R2923 T4318 T4322 arg1Of lost,in
R2924 T4321 T4319 arg2Of modification,from
R2925 T4321 T4320 arg1Of modification,epigenetic
R2926 T4325 T4322 arg2Of cancers,in
R2927 T4325 T4323 arg1Of cancers,multiple
R2928 T4325 T4324 arg1Of cancers,malignant
R2929 T4325 T4326 arg1Of cancers,","
R2930 T4325 T4328 arg1Of cancers,as
R2931 T4328 T4327 arg1Of as,such
R2932 T4332 T4329 arg1Of carcinoma,non-small
R2933 T4332 T4330 arg1Of carcinoma,cell
R2934 T4332 T4331 arg1Of carcinoma,lung
R2935 T4332 T4333 arg1Of carcinoma,(
R2936 T4332 T4340 arg1Of carcinoma,","
R2937 T4334 T4333 arg2Of Donati,(
R2938 T4334 T4335 arg1Of Donati,et
R2939 T4334 T4336 arg1Of Donati,al.
R2940 T4334 T4337 arg1Of Donati,","
R2941 T4338 T4337 arg2Of 2007,","
R2942 T4339 T4333 arg3Of ),(
R2943 T4340 T4360 arg1Of ",",","
R2944 T4342 T4341 arg1Of malignancies,hematopoietic
R2945 T4342 T4343 arg1Of malignancies,(
R2946 T4342 T4350 arg1Of malignancies,","
R2947 T4344 T4345 arg1Of Ishii,and
R2948 T4345 T4343 arg2Of and,(
R2949 T4345 T4347 arg1Of and,","
R2950 T4346 T4345 arg2Of Furukawa,and
R2951 T4348 T4347 arg2Of 2004,","
R2952 T4349 T4343 arg3Of ),(
R2953 T4350 T4340 arg2Of ",",","
R2954 T4350 T4353 arg1Of ",",(
R2955 T4352 T4350 arg2Of carcinoma,","
R2956 T4352 T4351 arg1Of carcinoma,gastric
R2957 T4354 T4353 arg2Of Aqeilan,(
R2958 T4354 T4355 arg1Of Aqeilan,et
R2959 T4354 T4356 arg1Of Aqeilan,al.
R2960 T4354 T4357 arg1Of Aqeilan,","
R2961 T4358 T4357 arg2Of 2004,","
R2962 T4359 T4353 arg3Of ),(
R2963 T4360 T4373 arg1Of ",",(
R2964 T4360 T4387 arg1Of ",",and
R2965 T4362 T4361 arg1Of carcinoma,pancreatic
R2966 T4362 T4363 arg1Of carcinoma,(
R2967 T4362 T4370 arg1Of carcinoma,","
R2968 T4364 T4363 arg2Of Kuroki,(
R2969 T4364 T4365 arg1Of Kuroki,et
R2970 T4364 T4366 arg1Of Kuroki,al.
R2971 T4364 T4367 arg1Of Kuroki,","
R2972 T4368 T4367 arg2Of 2004,","
R2973 T4369 T4363 arg3Of ),(
R2974 T4370 T4360 arg2Of ",",","
R2975 T4372 T4370 arg2Of carcinoma,","
R2976 T4372 T4371 arg1Of carcinoma,breast
R2977 T4374 T4373 arg2Of Guler,(
R2978 T4374 T4375 arg1Of Guler,et
R2979 T4374 T4376 arg1Of Guler,al.
R2980 T4374 T4377 arg1Of Guler,","
R2981 T4374 T4379 arg1Of Guler,;
R2982 T4378 T4377 arg2Of 2004,","
R2983 T4380 T4379 arg2Of Aqeilan,;
R2984 T4380 T4381 arg1Of Aqeilan,et
R2985 T4380 T4382 arg1Of Aqeilan,al.
R2986 T4380 T4383 arg1Of Aqeilan,","
R2987 T4384 T4383 arg2Of 2007,","
R2988 T4385 T4373 arg3Of ),(
R2989 T4387 T4328 arg2Of and,as
R2990 T4387 T4386 arg1Of and,","
R2991 T4388 T4387 arg2Of glioblastoma,and
R2992 T4388 T4389 arg1Of glioblastoma,multiforme
R2993 T4388 T4390 arg1Of glioblastoma,(
R2994 T4391 T4390 arg2Of Kosla,(
R2995 T4391 T4392 arg1Of Kosla,et
R2996 T4391 T4393 arg1Of Kosla,al.
R2997 T4391 T4394 arg1Of Kosla,","
R2998 T4395 T4394 arg2Of 2011,","
R2999 T4396 T4390 arg3Of ),(
R3000 T4397 T4398 arg1Of Restoration,of
R3001 T4397 T4401 arg1Of Restoration,prevents
R3002 T4400 T4398 arg2Of gene,of
R3003 T4400 T4399 arg1Of gene,WWOX
R3004 T4401 T4428 arg1Of prevents,(
R3005 T4403 T4404 arg1Of growth,of
R3006 T4403 T4407 arg1Of growth,(
R3007 T4403 T4414 arg1Of growth,","
R3008 T4406 T4404 arg2Of cancer,of
R3009 T4406 T4405 arg1Of cancer,lung
R3010 T4408 T4407 arg2Of Fabbri,(
R3011 T4408 T4409 arg1Of Fabbri,et
R3012 T4408 T4410 arg1Of Fabbri,al.
R3013 T4408 T4411 arg1Of Fabbri,","
R3014 T4412 T4411 arg2Of 2005,","
R3015 T4413 T4407 arg3Of ),(
R3016 T4414 T4401 arg2Of ",",prevents
R3017 T4414 T4402 arg1Of ",",the
R3018 T4416 T4415 arg1Of cancer,pancreatic
R3019 T4416 T4417 arg1Of cancer,(
R3020 T4416 T4425 arg1Of cancer,and
R3021 T4418 T4417 arg2Of Nakayama,(
R3022 T4418 T4419 arg1Of Nakayama,et
R3023 T4418 T4420 arg1Of Nakayama,al.
R3024 T4418 T4421 arg1Of Nakayama,","
R3025 T4422 T4421 arg2Of 2008,","
R3026 T4423 T4417 arg3Of ),(
R3027 T4425 T4414 arg2Of and,","
R3028 T4425 T4424 arg1Of and,","
R3029 T4427 T4425 arg2Of cancer,and
R3030 T4427 T4426 arg1Of cancer,prostate
R3031 T4429 T4428 arg2Of Hong,(
R3032 T4429 T4430 arg1Of Hong,et
R3033 T4429 T4431 arg1Of Hong,al.
R3034 T4429 T4432 arg1Of Hong,","
R3035 T4433 T4432 arg2Of 2009,","
R3036 T4434 T4428 arg3Of ),(
R3037 T4438 T4435 arg1Of domain,The
R3038 T4438 T4436 arg1Of domain,first
R3039 T4438 T4437 arg1Of domain,WW
R3040 T4438 T4439 arg1Of domain,of
R3041 T4438 T4441 arg1Of domain,may
R3042 T4438 T4442 arg1Of domain,interact
R3043 T4440 T4439 arg2Of WWOX,of
R3044 T4442 T4441 arg2Of interact,may
R3045 T4442 T4443 arg1Of interact,with
R3046 T4444 T4443 arg2Of proteins,with
R3047 T4444 T4445 arg1Of proteins,possessing
R3048 T4448 T4445 arg2Of motif,possessing
R3049 T4448 T4446 arg1Of motif,a
R3050 T4448 T4447 arg1Of motif,PPxY
R3051 T4448 T4449 arg1Of motif,(
R3052 T4448 T4453 arg1Of motif,as
R3053 T4450 T4449 arg2Of s,(
R3054 T4451 T4449 arg3Of ),(
R3055 T4453 T4452 arg1Of as,such
R3056 T4454 T4455 arg1Of AP-2γ,","
R3057 T4455 T4457 arg1Of ",",","
R3058 T4456 T4455 arg2Of p73,","
R3059 T4457 T4459 arg1Of ",",","
R3060 T4458 T4457 arg2Of ErbB4,","
R3061 T4459 T4461 arg1Of ",",","
R3062 T4460 T4459 arg2Of Ezrin,","
R3063 T4461 T4463 arg1Of ",",","
R3064 T4462 T4461 arg2Of SIMPLE,","
R3065 T4463 T4465 arg1Of ",",","
R3066 T4464 T4463 arg2Of c-Jun,","
R3067 T4465 T4468 arg1Of ",",and
R3068 T4466 T4465 arg2Of RUNX4,","
R3069 T4468 T4453 arg2Of and,as
R3070 T4468 T4467 arg1Of and,","
R3071 T4470 T4468 arg2Of others,and
R3072 T4470 T4469 arg1Of others,many
R3073 T4470 T4471 arg1Of others,(
R3074 T4472 T4471 arg2Of Chang,(
R3075 T4472 T4473 arg1Of Chang,et
R3076 T4472 T4474 arg1Of Chang,al.
R3077 T4472 T4475 arg1Of Chang,","
R3078 T4472 T4477 arg1Of Chang,;
R3079 T4476 T4475 arg2Of 2007,","
R3080 T4478 T4477 arg2Of Salah,;
R3081 T4478 T4479 arg1Of Salah,et
R3082 T4478 T4480 arg1Of Salah,al.
R3083 T4478 T4481 arg1Of Salah,","
R3084 T4478 T4483 arg1Of Salah,;
R3085 T4478 T4489 arg1Of Salah,;
R3086 T4482 T4481 arg2Of 2012,","
R3087 T4484 T4485 arg1Of Su,et
R3088 T4484 T4486 arg1Of Su,al.
R3089 T4484 T4487 arg1Of Su,","
R3090 T4487 T4483 arg2Of ",",;
R3091 T4488 T4487 arg2Of 2012,","
R3092 T4490 T4489 arg2Of Figure,;
R3093 T4490 T4491 arg1Of Figure,1
R3094 T4492 T4471 arg3Of ),(
R3095 T4495 T4493 arg1Of WWOX,Transiently
R3096 T4495 T4494 arg2Of WWOX,overexpressed
R3097 T4495 T4496 arg1Of WWOX,binds
R3098 T4495 T4506 arg1Of WWOX,block
R3099 T4496 T4505 arg1Of binds,and
R3100 T4498 T4497 arg1Of factors,transcription
R3101 T4499 T4500 arg1Of AP-2,","
R3102 T4500 T4503 arg1Of ",",and
R3103 T4501 T4500 arg2Of p73,","
R3104 T4503 T4496 arg2Of and,binds
R3105 T4503 T4498 arg1Of and,factors
R3106 T4503 T4502 arg1Of and,","
R3107 T4504 T4503 arg2Of c-Jun,and
R3108 T4505 T4512 arg1Of and,","
R3109 T4505 T4513 arg1Of and,which
R3110 T4505 T4514 arg1Of and,suppresses
R3111 T4506 T4505 arg2Of block,and
R3112 T4506 T4511 arg1Of block,vitro
R3113 T4509 T4506 arg2Of relocation,block
R3114 T4509 T4507 arg1Of relocation,their
R3115 T4509 T4508 arg1Of relocation,nuclear
R3116 T4511 T4510 arg1Of vitro,in
R3117 T4514 T4518 arg1Of suppresses,(
R3118 T4517 T4514 arg2Of survival,suppresses
R3119 T4517 T4515 arg1Of survival,cancer
R3120 T4517 T4516 arg1Of survival,cell
R3121 T4519 T4518 arg2Of Salah,(
R3122 T4519 T4520 arg1Of Salah,et
R3123 T4519 T4521 arg1Of Salah,al.
R3124 T4519 T4522 arg1Of Salah,","
R3125 T4523 T4522 arg2Of 2012,","
R3126 T4524 T4518 arg3Of ),(
R3127 T4527 T4525 arg2Of contrast,In
R3128 T4527 T4526 arg1Of contrast,stark
R3129 T4529 T4530 arg1Of Wwox,co-migrates
R3130 T4530 T4525 arg1Of co-migrates,In
R3131 T4530 T4528 arg1Of co-migrates,","
R3132 T4530 T4531 arg1Of co-migrates,with
R3133 T4532 T4533 arg1Of proapoptotic,and
R3134 T4534 T4533 arg2Of pro-survival,and
R3135 T4536 T4531 arg2Of factors,with
R3136 T4536 T4532 arg1Of factors,proapoptotic
R3137 T4536 T4534 arg1Of factors,pro-survival
R3138 T4536 T4535 arg1Of factors,transcription
R3139 T4536 T4537 arg1Of factors,to
R3140 T4539 T4537 arg2Of nuclei,to
R3141 T4539 T4538 arg1Of nuclei,the
R3142 T4539 T4540 arg1Of nuclei,of
R3143 T4541 T4540 arg2Of neurons,of
R3144 T4541 T4542 arg1Of neurons,upon
R3145 T4545 T4542 arg2Of axotomy,upon
R3146 T4545 T4543 arg1Of axotomy,sciatic
R3147 T4545 T4544 arg1Of axotomy,nerve
R3148 T4545 T4546 arg1Of axotomy,in
R3149 T4547 T4546 arg2Of rats,in
R3150 T4547 T4548 arg1Of rats,(
R3151 T4549 T4548 arg2Of Li,(
R3152 T4549 T4550 arg1Of Li,et
R3153 T4549 T4551 arg1Of Li,al.
R3154 T4549 T4552 arg1Of Li,","
R3155 T4553 T4552 arg2Of 2009,","
R3156 T4554 T4548 arg3Of ),(
R3157 T4556 T4555 arg1Of blocking,No
R3158 T4556 T4557 arg1Of blocking,of
R3159 T4556 T4562 arg1Of blocking,to
R3160 T4556 T4565 arg1Of blocking,by
R3161 T4556 T4567 arg1Of blocking,was
R3162 T4556 T4568 arg2Of blocking,observed
R3163 T4558 T4557 arg2Of translocation,of
R3164 T4558 T4559 arg1Of translocation,of
R3165 T4561 T4559 arg2Of factors,of
R3166 T4561 T4560 arg1Of factors,transcription
R3167 T4564 T4562 arg2Of nuclei,to
R3168 T4564 T4563 arg1Of nuclei,the
R3169 T4566 T4565 arg2Of Wwox,by
R3170 T4568 T4567 arg2Of observed,was
R3171 T4571 T4569 arg2Of conditions,Under
R3172 T4571 T4570 arg1Of conditions,stress
R3173 T4573 T4574 arg1Of WWOX,is
R3174 T4573 T4575 arg2Of WWOX,activated
R3175 T4573 T4582 arg1Of WWOX,binds
R3176 T4575 T4574 arg2Of activated,is
R3177 T4575 T4576 arg1Of activated,via
R3178 T4575 T4581 arg1Of activated,and
R3179 T4577 T4576 arg2Of phosphorylation,via
R3180 T4577 T4578 arg1Of phosphorylation,at
R3181 T4579 T4578 arg2Of Tyr33,at
R3182 T4581 T4569 arg1Of and,Under
R3183 T4581 T4572 arg1Of and,","
R3184 T4581 T4580 arg1Of and,","
R3185 T4582 T4581 arg2Of binds,and
R3186 T4582 T4584 arg1Of binds,independently
R3187 T4582 T4589 arg1Of binds,(
R3188 T4583 T4582 arg2Of proteins,binds
R3189 T4584 T4585 arg1Of independently,of
R3190 T4588 T4585 arg2Of motif,of
R3191 T4588 T4586 arg1Of motif,the
R3192 T4588 T4587 arg1Of motif,PPxY
R3193 T4590 T4591 arg1Of Chang,et
R3194 T4590 T4592 arg1Of Chang,al.
R3195 T4590 T4593 arg1Of Chang,","
R3196 T4593 T4595 arg1Of ",",","
R3197 T4594 T4593 arg2Of 2001,","
R3198 T4595 T4589 arg2Of ",",(
R3199 T4595 T4597 arg1Of ",",","
R3200 T4596 T4595 arg2Of 2003,","
R3201 T4598 T4599 arg1Of 2005a,","
R3202 T4599 T4601 arg1Of ",",","
R3203 T4600 T4599 arg2Of b,","
R3204 T4601 T4597 arg2Of ",",","
R3205 T4601 T4603 arg1Of ",",","
R3206 T4602 T4601 arg2Of 2007,","
R3207 T4604 T4603 arg2Of 2010,","
R3208 T4605 T4589 arg3Of ),(
R3209 T4607 T4606 arg2Of WWOX,Activated
R3210 T4607 T4609 arg1Of WWOX,interacts
R3211 T4609 T4608 arg1Of interacts,physically
R3212 T4609 T4610 arg1Of interacts,with
R3213 T4613 T4610 arg2Of p53,with
R3214 T4613 T4611 arg1Of p53,serine
R3215 T4613 T4612 arg1Of p53,46-phosphorylated
R3216 T4613 T4614 arg1Of p53,(
R3217 T4613 T4618 arg1Of p53,","
R3218 T4613 T4619 arg1Of p53,which
R3219 T4613 T4620 arg1Of p53,stabilizes
R3220 T4615 T4614 arg2Of Figure,(
R3221 T4615 T4616 arg1Of Figure,1
R3222 T4617 T4614 arg3Of ),(
R3223 T4620 T4626 arg1Of stabilizes,(
R3224 T4621 T4622 arg1Of p53,and
R3225 T4622 T4620 arg2Of and,stabilizes
R3226 T4625 T4622 arg2Of function,and
R3227 T4625 T4623 arg1Of function,its
R3228 T4625 T4624 arg1Of function,apoptotic
R3229 T4627 T4626 arg2Of Chang,(
R3230 T4627 T4628 arg1Of Chang,et
R3231 T4627 T4629 arg1Of Chang,al.
R3232 T4627 T4630 arg1Of Chang,","
R3233 T4631 T4630 arg2Of 2005b,","
R3234 T4632 T4626 arg3Of ),(
R3235 T4635 T4636 arg1Of WWOX,binds
R3236 T4636 T4633 arg1Of binds,Also
R3237 T4636 T4634 arg1Of binds,","
R3238 T4638 T4636 arg2Of proteins,binds
R3239 T4638 T4637 arg2Of proteins,Disheveled
R3240 T4638 T4639 arg1Of proteins,(
R3241 T4638 T4642 arg1Of proteins,","
R3242 T4638 T4643 arg1Of proteins,which
R3243 T4638 T4644 arg1Of proteins,are
R3244 T4640 T4639 arg2Of Dvl,(
R3245 T4641 T4639 arg3Of ),(
R3246 T4646 T4644 arg2Of components,are
R3247 T4646 T4645 arg1Of components,key
R3248 T4646 T4647 arg1Of components,in
R3249 T4650 T4647 arg2Of pathway,in
R3250 T4650 T4648 arg1Of pathway,Wnt/β-catenin
R3251 T4650 T4649 arg1Of pathway,signaling
R3252 T4650 T4651 arg1Of pathway,(
R3253 T4652 T4651 arg2Of Figure,(
R3254 T4652 T4653 arg1Of Figure,1
R3255 T4654 T4651 arg3Of ),(
R3256 T4657 T4655 arg1Of motif,No
R3257 T4657 T4656 arg1Of motif,PPxY
R3258 T4657 T4658 arg1Of motif,is
R3259 T4657 T4662 arg1Of motif,overexpressed
R3260 T4657 T4671 arg1Of motif,blocks
R3261 T4661 T4659 arg2Of Transiently,in
R3262 T4661 T4660 arg1Of Transiently,Dvl.
R3263 T4662 T4658 arg2Of overexpressed,is
R3264 T4662 T4659 arg1Of overexpressed,in
R3265 T4662 T4666 arg1Of overexpressed,in
R3266 T4662 T4669 arg1Of overexpressed,and
R3267 T4665 T4662 arg2Of Dvl-2,overexpressed
R3268 T4665 T4663 arg1Of Dvl-2,WWOX
R3269 T4665 T4664 arg1Of Dvl-2,sequesters
R3270 T4668 T4666 arg2Of cytoplasm,in
R3271 T4668 T4667 arg1Of cytoplasm,the
R3272 T4671 T4669 arg2Of blocks,and
R3273 T4671 T4670 arg1Of blocks,thereby
R3274 T4675 T4671 arg2Of activity,blocks
R3275 T4675 T4672 arg1Of activity,Dvl-2-mediated
R3276 T4675 T4673 arg1Of activity,TCF
R3277 T4675 T4674 arg1Of activity,transcriptional
R3278 T4675 T4676 arg1Of activity,(
R3279 T4677 T4676 arg2Of Bouteille,(
R3280 T4677 T4678 arg1Of Bouteille,et
R3281 T4677 T4679 arg1Of Bouteille,al.
R3282 T4677 T4680 arg1Of Bouteille,","
R3283 T4681 T4680 arg2Of 2009,","
R3284 T4682 T4676 arg3Of ),(
R3285 T4684 T4683 arg2Of WWOX,Overexpressed
R3286 T4684 T4685 arg1Of WWOX,induces
R3287 T4684 T4688 arg1Of WWOX,inhibits
R3288 T4685 T4687 arg1Of induces,and
R3289 T4686 T4685 arg2Of apoptosis,induces
R3290 T4688 T4687 arg2Of inhibits,and
R3291 T4688 T4707 arg1Of inhibits,(
R3292 T4689 T4690 arg1Of proliferation,of
R3293 T4689 T4702 arg1Of proliferation,and
R3294 T4694 T4690 arg2Of cells,of
R3295 T4694 T4691 arg1Of cells,human
R3296 T4694 T4692 arg1Of cells,hepatic
R3297 T4694 T4693 arg1Of cells,carcinoma
R3298 T4694 T4695 arg1Of cells,(
R3299 T4696 T4695 arg2Of Hu,(
R3300 T4696 T4697 arg1Of Hu,et
R3301 T4696 T4698 arg1Of Hu,al.
R3302 T4696 T4699 arg1Of Hu,","
R3303 T4700 T4699 arg2Of 2012,","
R3304 T4701 T4695 arg3Of ),(
R3305 T4702 T4688 arg2Of and,inhibits
R3306 T4706 T4702 arg2Of types,and
R3307 T4706 T4703 arg1Of types,many
R3308 T4706 T4704 arg1Of types,cancer
R3309 T4706 T4705 arg1Of types,cell
R3310 T4708 T4709 arg1Of Chang,et
R3311 T4708 T4710 arg1Of Chang,al.
R3312 T4708 T4711 arg1Of Chang,","
R3313 T4711 T4713 arg1Of ",",","
R3314 T4712 T4711 arg2Of 2007,","
R3315 T4713 T4715 arg1Of ",",;
R3316 T4714 T4713 arg2Of 2010,","
R3317 T4715 T4707 arg2Of ;,(
R3318 T4715 T4721 arg1Of ;,;
R3319 T4716 T4717 arg1Of Salah,et
R3320 T4716 T4718 arg1Of Salah,al.
R3321 T4716 T4719 arg1Of Salah,","
R3322 T4719 T4715 arg2Of ",",;
R3323 T4720 T4719 arg2Of 2012,","
R3324 T4722 T4721 arg2Of Su,;
R3325 T4722 T4723 arg1Of Su,et
R3326 T4722 T4724 arg1Of Su,al.
R3327 T4722 T4725 arg1Of Su,","
R3328 T4726 T4725 arg2Of 2012,","
R3329 T4727 T4707 arg3Of ),(
R3330 T4728 T4729 arg1Of WWOX,enhances
R3331 T4728 T4738 arg1Of WWOX,down-regulating
R3332 T4728 T4745 arg1Of WWOX,up-regulating
R3333 T4729 T4737 arg1Of enhances,by
R3334 T4732 T4729 arg2Of function,enhances
R3335 T4732 T4730 arg1Of function,the
R3336 T4732 T4731 arg1Of function,cytotoxic
R3337 T4732 T4733 arg1Of function,of
R3338 T4736 T4733 arg2Of factor,of
R3339 T4736 T4734 arg1Of factor,tumor
R3340 T4736 T4735 arg1Of factor,necrosis
R3341 T4738 T4744 arg1Of down-regulating,and
R3342 T4741 T4742 arg1Of Bcl-2,and
R3343 T4742 T4738 arg2Of and,down-regulating
R3344 T4742 T4739 arg1Of and,apoptosis
R3345 T4742 T4740 arg1Of and,inhibitor
R3346 T4743 T4742 arg2Of Bcl-xL,and
R3347 T4744 T4737 arg2Of and,by
R3348 T4745 T4744 arg2Of up-regulating,and
R3349 T4745 T4748 arg1Of up-regulating,(
R3350 T4747 T4745 arg2Of p53,up-regulating
R3351 T4747 T4746 arg1Of p53,apoptotic
R3352 T4749 T4748 arg2Of Chang,(
R3353 T4749 T4750 arg1Of Chang,et
R3354 T4749 T4751 arg1Of Chang,al.
R3355 T4749 T4752 arg1Of Chang,","
R3356 T4753 T4752 arg2Of 2001,","
R3357 T4754 T4748 arg3Of ),(
R3358 T4757 T4758 arg1Of WWOX,mediates
R3359 T4758 T4755 arg1Of mediates,Also
R3360 T4758 T4756 arg1Of mediates,","
R3361 T4758 T4761 arg1Of mediates,synergistically
R3362 T4758 T4762 arg1Of mediates,with
R3363 T4760 T4758 arg2Of death,mediates
R3364 T4760 T4759 arg1Of death,cell
R3365 T4763 T4762 arg2Of p53,with
R3366 T4765 T4764 arg2Of exposure,Upon
R3367 T4765 T4766 arg1Of exposure,to
R3368 T4765 T4771 arg1Of exposure,","
R3369 T4765 T4773 arg1Of exposure,as
R3370 T4767 T4768 arg1Of chemicals,or
R3371 T4768 T4766 arg2Of or,to
R3372 T4770 T4768 arg2Of stress,or
R3373 T4770 T4769 arg1Of stress,environmental
R3374 T4773 T4772 arg1Of as,such
R3375 T4775 T4774 arg1Of irradiation,UV
R3376 T4775 T4776 arg1Of irradiation,and
R3377 T4776 T4773 arg2Of and,as
R3378 T4778 T4776 arg2Of drugs,and
R3379 T4778 T4777 arg1Of drugs,chemotherapeutic
R3380 T4780 T4781 arg1Of WWOX,undergoes
R3381 T4781 T4764 arg1Of undergoes,Upon
R3382 T4781 T4779 arg1Of undergoes,","
R3383 T4781 T4783 arg1Of undergoes,in
R3384 T4781 T4789 arg1Of undergoes,","
R3385 T4781 T4790 modOf undergoes,followed
R3386 T4782 T4781 arg2Of phosphorylation,undergoes
R3387 T4784 T4785 arg1Of Tyr33,and
R3388 T4785 T4783 arg2Of and,in
R3389 T4788 T4785 arg2Of sites,and
R3390 T4788 T4786 arg1Of sites,probably
R3391 T4788 T4787 arg1Of sites,others
R3392 T4790 T4791 arg1Of followed,by
R3393 T4792 T4791 arg2Of relocating,by
R3394 T4792 T4793 arg1Of relocating,to
R3395 T4794 T4795 arg1Of mitochondria,or
R3396 T4795 T4793 arg2Of or,to
R3397 T4795 T4797 arg1Of or,for
R3398 T4796 T4795 arg2Of nuclei,or
R3399 T4798 T4797 arg2Of inducing,for
R3400 T4799 T4798 arg2Of apoptosis,inducing
R3401 T4799 T4800 arg1Of apoptosis,(
R3402 T4801 T4802 arg1Of Chang,et
R3403 T4801 T4803 arg1Of Chang,al.
R3404 T4801 T4804 arg1Of Chang,","
R3405 T4804 T4800 arg2Of ",",(
R3406 T4804 T4806 arg1Of ",",","
R3407 T4805 T4804 arg2Of 2007,","
R3408 T4807 T4806 arg2Of 2010,","
R3409 T4808 T4800 arg3Of ),(
R3410 T4809 T4810 arg1Of WWOX,binds
R3411 T4811 T4810 arg2Of MEK,binds
R3412 T4811 T4812 arg1Of MEK,in
R3413 T4815 T4812 arg2Of cells,in
R3414 T4815 T4813 arg1Of cells,Jurkat
R3415 T4815 T4814 arg1Of cells,T
R3416 T4815 T4816 arg1Of cells,(
R3417 T4817 T4816 arg2Of Lin,(
R3418 T4817 T4818 arg1Of Lin,et
R3419 T4817 T4819 arg1Of Lin,al.
R3420 T4817 T4820 arg1Of Lin,","
R3421 T4821 T4820 arg2Of 2011,","
R3422 T4822 T4816 arg3Of ),(
R3423 T4825 T4823 arg1Of acetate,Phorbol
R3424 T4825 T4824 arg1Of acetate,myristate
R3425 T4825 T4826 arg1Of acetate,(
R3426 T4825 T4829 arg1Of acetate,dissociates
R3427 T4825 T4834 arg1Of acetate,induces
R3428 T4827 T4826 arg2Of PMA,(
R3429 T4828 T4826 arg3Of ),(
R3430 T4829 T4833 arg1Of dissociates,and
R3431 T4832 T4829 arg2Of complex,dissociates
R3432 T4832 T4830 arg1Of complex,the
R3433 T4832 T4831 arg1Of complex,MEK/WWOX
R3434 T4834 T4833 arg2Of induces,and
R3435 T4835 T4834 arg2Of WWOX,induces
R3436 T4835 T4837 arg1Of WWOX,translocate
R3437 T4837 T4834 arg3Of translocate,induces
R3438 T4837 T4836 arg1Of translocate,to
R3439 T4837 T4838 arg1Of translocate,to
R3440 T4840 T4838 arg2Of mitochondria,to
R3441 T4840 T4839 arg1Of mitochondria,the
R3442 T4840 T4841 modOf mitochondria,to
R3443 T4842 T4841 arg1Of induce,to
R3444 T4842 T4844 arg1Of induce,","
R3445 T4842 T4845 arg1Of induce,whereas
R3446 T4843 T4842 arg2Of apoptosis,induce
R3447 T4846 T4847 arg1Of MEK,relocates
R3448 T4847 T4845 arg2Of relocates,whereas
R3449 T4847 T4848 arg1Of relocates,to
R3450 T4851 T4848 arg2Of raft,to
R3451 T4851 T4849 arg1Of raft,the
R3452 T4851 T4850 arg1Of raft,lipid
R3453 T4852 T4853 arg1Of Inhibition,of
R3454 T4852 T4856 arg1Of Inhibition,increases
R3455 T4855 T4853 arg2Of activity,of
R3456 T4855 T4854 arg1Of activity,MEK
R3457 T4856 T4863 arg1Of increases,(
R3458 T4858 T4856 arg2Of suppression,increases
R3459 T4858 T4857 arg1Of suppression,TMZ-induced
R3460 T4858 T4859 arg1Of suppression,of
R3461 T4862 T4859 arg2Of growth,of
R3462 T4862 T4860 arg1Of growth,cancer
R3463 T4862 T4861 arg1Of growth,cell
R3464 T4864 T4863 arg2Of Holt,(
R3465 T4864 T4865 arg1Of Holt,et
R3466 T4864 T4866 arg1Of Holt,al.
R3467 T4864 T4867 arg1Of Holt,","
R3468 T4868 T4867 arg2Of 2012,","
R3469 T4869 T4863 arg3Of ),(
R3470 T4871 T4870 arg1Of expression,Ectopic
R3471 T4871 T4872 arg1Of expression,of
R3472 T4871 T4874 arg1Of expression,in
R3473 T4871 T4877 arg1Of expression,induces
R3474 T4871 T4883 arg1Of expression,induces
R3475 T4873 T4872 arg2Of WWOX,of
R3476 T4876 T4874 arg2Of cells,in
R3477 T4876 T4875 arg1Of cells,A549
R3478 T4877 T4882 arg1Of induces,and
R3479 T4878 T4879 arg1Of procaspase-3,and
R3480 T4879 T4877 arg2Of and,induces
R3481 T4881 T4879 arg2Of activation,and
R3482 T4881 T4880 arg1Of activation,procaspase-9
R3483 T4882 T4896 arg1Of and,)
R3484 T4883 T4882 arg2Of induces,and
R3485 T4885 T4883 arg2Of C,induces
R3486 T4885 T4884 arg1Of C,cytochrome
R3487 T4885 T4886 arg1Of C,releasing
R3488 T4886 T4887 arg1Of releasing,from
R3489 T4889 T4887 arg2Of mitochondria,from
R3490 T4889 T4888 arg1Of mitochondria,the
R3491 T4891 T4886 arg2Of Zhang,releasing
R3492 T4891 T4890 arg1Of Zhang,(
R3493 T4891 T4892 arg1Of Zhang,et
R3494 T4891 T4893 arg1Of Zhang,al.
R3495 T4891 T4894 arg1Of Zhang,","
R3496 T4895 T4894 arg2Of 2012a,","
R3497 T4898 T4897 arg1Of C1q,Complement
R3498 T4898 T4899 arg1Of C1q,induces
R3499 T4898 T4906 arg1Of C1q,leads
R3500 T4899 T4903 arg1Of induces,in
R3501 T4899 T4905 arg1Of induces,and
R3502 T4902 T4899 arg2Of phosphorylation,induces
R3503 T4902 T4900 arg1Of phosphorylation,ectopic
R3504 T4902 T4901 arg1Of phosphorylation,WWOX
R3505 T4904 T4903 arg2Of Try33,in
R3506 T4906 T4905 arg2Of leads,and
R3507 T4906 T4907 arg1Of leads,to
R3508 T4906 T4910 arg1Of leads,independently
R3509 T4906 T4917 arg1Of leads,(
R3510 T4909 T4907 arg2Of apoptosis,to
R3511 T4909 T4908 arg1Of apoptosis,cell
R3512 T4910 T4911 arg1Of independently,of
R3513 T4916 T4911 arg2Of pathway,of
R3514 T4916 T4912 arg1Of pathway,the
R3515 T4916 T4913 arg1Of pathway,classical
R3516 T4916 T4914 arg1Of pathway,complement
R3517 T4916 T4915 arg1Of pathway,activation
R3518 T4918 T4917 arg2Of Hong,(
R3519 T4918 T4919 arg1Of Hong,et
R3520 T4918 T4920 arg1Of Hong,al.
R3521 T4918 T4921 arg1Of Hong,","
R3522 T4922 T4921 arg2Of 2009,","
R3523 T4923 T4917 arg3Of ),(
R3524 T4925 T4924 arg1Of portion,A
R3525 T4925 T4926 arg1Of portion,of
R3526 T4925 T4928 arg1Of portion,is
R3527 T4925 T4929 arg2Of portion,anchored
R3528 T4927 T4926 arg2Of WWOX,of
R3529 T4929 T4928 arg2Of anchored,is
R3530 T4929 T4930 arg1Of anchored,in
R3531 T4929 T4934 arg1Of anchored,via
R3532 T4933 T4930 arg2Of area,in
R3533 T4933 T4931 arg1Of area,the
R3534 T4933 T4932 arg1Of area,membrane/cytoskeleton
R3535 T4935 T4934 arg2Of binding,via
R3536 T4935 T4936 arg1Of binding,with
R3537 T4938 T4937 arg1Of Hyal-2,hyaluronidase
R3538 T4938 T4939 arg1Of Hyal-2,(
R3539 T4938 T4946 arg1Of Hyal-2,and
R3540 T4940 T4939 arg2Of Hsu,(
R3541 T4940 T4941 arg1Of Hsu,et
R3542 T4940 T4942 arg1Of Hsu,al.
R3543 T4940 T4943 arg1Of Hsu,","
R3544 T4944 T4943 arg2Of 2009,","
R3545 T4945 T4939 arg3Of ),(
R3546 T4946 T4936 arg2Of and,with
R3547 T4947 T4946 arg2Of Phospho-Ezrin,and
R3548 T4947 T4948 arg1Of Phospho-Ezrin,(
R3549 T4949 T4948 arg2Of Jin,(
R3550 T4949 T4950 arg1Of Jin,et
R3551 T4949 T4951 arg1Of Jin,al.
R3552 T4949 T4952 arg1Of Jin,","
R3553 T4953 T4952 arg2Of 2006,","
R3554 T4954 T4948 arg3Of ),(
R3555 T4958 T4955 arg1Of β1,Transforming
R3556 T4958 T4956 arg1Of β1,growth
R3557 T4958 T4957 arg1Of β1,factor
R3558 T4958 T4959 arg1Of β1,binds
R3559 T4959 T4961 arg1Of binds,as
R3560 T4960 T4959 arg2Of Hyal-2,binds
R3561 T4964 T4961 arg2Of receptor,as
R3562 T4964 T4962 arg1Of receptor,a
R3563 T4964 T4963 arg1Of receptor,cognate
R3564 T4964 T4965 modOf receptor,to
R3565 T4966 T4965 arg1Of signal,to
R3566 T4968 T4966 arg2Of formation,signal
R3567 T4968 T4967 arg1Of formation,the
R3568 T4968 T4969 arg1Of formation,of
R3569 T4968 T4973 modOf formation,to
R3570 T4972 T4969 arg2Of complex,of
R3571 T4972 T4970 arg1Of complex,the
R3572 T4972 T4971 arg1Of complex,WWOX/Hyal-2/Smad4
R3573 T4974 T4973 arg1Of relocate,to
R3574 T4974 T4975 arg1Of relocate,to
R3575 T4977 T4975 arg2Of nucleus,to
R3576 T4977 T4976 arg1Of nucleus,the
R3577 T4977 T4978 arg1Of nucleus,for
R3578 T4979 T4978 arg2Of enhancing,for
R3579 T4979 T4984 arg1Of enhancing,(
R3580 T4983 T4979 arg2Of activity,enhancing
R3581 T4983 T4980 arg1Of activity,the
R3582 T4983 T4981 arg1Of activity,SMAD-driven
R3584 T4985 T4984 arg2Of Hsu,(
R3585 T4985 T4986 arg1Of Hsu,et
R3586 T4985 T4987 arg1Of Hsu,al.
R3587 T4985 T4988 arg1Of Hsu,","
R3588 T4989 T4988 arg2Of 2009,","
R3589 T4990 T4984 arg3Of ),(
R4805 T6868 T6867 arg2Of p53,Activated
R4806 T6868 T6869 arg1Of p53,mediates
R4807 T6870 T6871 arg1Of apoptosis,","
R4808 T6871 T6875 arg1Of ",",","
R4809 T6874 T6871 arg2Of arrest,","
R4810 T6874 T6872 arg1Of arrest,cell
R4811 T6874 T6873 arg1Of arrest,cycle
R4812 T6875 T6877 arg1Of ",",","
R4813 T6876 T6875 arg2Of senescence,","
R4814 T6877 T6881 arg1Of ",",or
R4815 T6879 T6877 arg2Of repair,","
R4816 T6879 T6878 arg1Of repair,DNA
R4817 T6881 T6869 arg2Of or,mediates
R4818 T6881 T6880 arg1Of or,","
R4819 T6882 T6881 arg2Of metabolism,or
R4820 T6882 T6883 arg1Of metabolism,(
R4821 T6884 T6885 arg1Of Lane,and
R4822 T6885 T6883 arg2Of and,(
R4823 T6885 T6887 arg1Of and,","
R4824 T6886 T6885 arg2Of Levine,and
R4825 T6888 T6887 arg2Of 2010,","
R4826 T6889 T6883 arg3Of ),(
R4827 T6892 T6890 arg1Of structures,The
R4828 T6892 T6891 arg1Of structures,primary
R4829 T6892 T6893 arg1Of structures,of
R4830 T6894 T6893 arg2Of p53,of
R4831 T6897 T6896 arg1Of isoforms,its
R4832 T6897 T6898 arg1Of isoforms,are
R4833 T6897 T6899 arg2Of isoforms,depicted
R4834 T6899 T6898 arg2Of depicted,are
R4835 T6901 T6900 arg2Of Figure,(
R4836 T6901 T6902 arg1Of Figure,2
R4837 T6903 T6900 arg3Of ),(
R4838 T6904 T6899 arg3Of . p,depicted
R4839 T6904 T6900 arg1Of . p,(
R4840 T6905 T6909 arg1Of 53 indu,ar
R4841 T6908 T6905 arg2Of cycle ,53 indu
R4842 T6908 T6906 arg1Of cycle ,ces
R4843 T6908 T6907 arg1Of cycle ,cell
R4844 T6910 T6909 arg2Of rest by transac,ar
R4845 T6911 T6910 arg2Of tivat,rest by transac
R4846 T6911 T6913 arg1Of tivat,ge
R4847 T6913 T6912 arg1Of ge,ing
R4848 T6917 T6913 arg2Of nas,ge
R4849 T6917 T6914 arg1Of nas,nes such as cycl
R4850 T6917 T6915 arg1Of nas,in-dep
R4851 T6917 T6916 arg1Of nas,endent ki
R4852 T6919 T6918 arg1Of in,e
R4853 T6922 T6920 arg1Of r m,hibitor
R4854 T6922 T6921 arg1Of r m,"p21, o"
R4855 T6922 T6923 arg1Of r m,icroRNA
R4856 T6922 T6926 arg1Of r m,induces apoptos
R4857 T6922 T6941 arg1Of r m,", PUMA, SC"
R4858 T6923 T6925 arg1Of icroRNA,3
R4859 T6924 T6923 arg2Of miR34. p5,icroRNA
R4860 T6926 T6940 arg1Of induces apoptos,BAX
R4861 T6928 T6926 arg2Of ctiva,induces apoptos
R4862 T6928 T6927 arg1Of ctiva,is by transa
R4863 T6928 T6930 arg1Of ctiva,pr
R4864 T6930 T6929 arg1Of pr,ting
R4865 T6931 T6932 arg1Of oap,o
R4866 T6932 T6934 arg1Of o,i
R4867 T6933 T6932 arg2Of ptot,o
R4868 T6934 T6937 arg1Of i,suc
R4869 T6935 T6934 arg2Of c gene,i
R4870 T6937 T6930 arg2Of suc,pr
R4871 T6937 T6936 arg1Of suc,s
R4872 T6938 T6937 arg2Of h a,suc
R4873 T6940 T6925 arg2Of BAX,3
R4874 T6940 T6939 arg1Of BAX,s
R4875 T6941 T6940 arg2Of ", PUMA, SC",BAX
R4876 T6945 T6941 arg2Of nhibi,", PUMA, SC"
R4877 T6945 T6942 arg1Of nhibi,OTI
R4878 T6945 T6943 arg1Of nhibi,"N, and FAS, a"
R4879 T6945 T6944 arg1Of nhibi,nd i
R4880 T6947 T6948 arg1Of ing ,the
R4881 T6948 T6946 arg2Of the,t
R4882 T6948 T6950 arg1Of the,o
R4883 T6949 T6948 arg2Of antiap,the
R4884 T6951 T6950 arg2Of ptot,o
R4885 T6952 T6946 arg3Of i,t
R4886 T6953 T6954 arg1Of c g,ene BCL-
R4887 T6954 T6960 arg1Of ene BCL-,t
R4888 T6954 T6961 arg1Of ene BCL-,riggers p
R4889 T6959 T6954 arg2Of 0). p53 ,ene BCL-
R4890 T6959 T6955 arg1Of 0). p53 ,2 (Lane and
R4891 T6959 T6956 arg1Of 0). p53 ,Le
R4892 T6959 T6957 arg1Of 0). p53 ,vine
R4893 T6959 T6958 arg1Of 0). p53 ,", 201"
R4894 T6962 T6961 arg2Of ro-s,riggers p
R4895 T6964 T6962 arg2Of val o,ro-s
R4896 T6964 T6963 arg1Of val o,urvi
R4897 T6967 T6966 arg1Of l death r,cel
R4898 T6967 T6968 arg1Of l death r,es
R4899 T6971 T6968 arg2Of pendin,es
R4900 T6971 T6969 arg1Of pendin,pon
R4901 T6971 T6970 arg1Of pendin,"se, de"
R4902 T6973 T6972 arg1Of upo,g
R4903 T6975 T6974 arg1Of ell ty,n c
R4904 T6975 T6976 arg1Of ell ty,pe
R4905 T6978 T6976 arg2Of ntensi,pe
R4906 T6978 T6977 arg1Of ntensi,"s, the i"
R4907 T6980 T6979 arg2Of y of the,t
R4908 T6980 T6981 arg1Of y of the,st
R4909 T6980 T6982 arg1Of y of the,res
R4910 T6980 T6983 arg1Of y of the,s
R4911 T6984 T6983 arg2Of sign,s
R4912 T6985 T6979 arg3Of a,t
R4913 T6988 T6989 arg1Of p53,plays
R4914 T6988 T6993 arg1Of p53,controlling
R4915 T6989 T6986 arg1Of plays,Also
R4916 T6989 T6987 arg1Of plays,","
R4917 T6989 T6992 arg1Of plays,in
R4918 T6991 T6989 arg2Of role,plays
R4919 T6991 T6990 arg1Of role,a
R4920 T6993 T6992 arg2Of controlling,in
R4921 T6993 T6996 arg1Of controlling,via
R4922 T6995 T6993 arg2Of motility,controlling
R4923 T6995 T6994 arg1Of motility,cell
R4924 T6997 T7016 arg1Of regulating,(
R4925 T6997 T7024 arg1Of regulating,and
R4926 T6999 T6997 arg2Of expression,regulating
R4927 T6999 T6998 arg1Of expression,the
R4928 T6999 T7000 arg1Of expression,of
R4929 T7003 T7001 arg1Of α-actin,smooth
R4930 T7003 T7002 arg1Of α-actin,muscle
R4931 T7003 T7004 arg1Of α-actin,(
R4932 T7003 T7011 arg1Of α-actin,","
R4933 T7005 T7004 arg2Of Comer,(
R4934 T7005 T7006 arg1Of Comer,et
R4935 T7005 T7007 arg1Of Comer,al.
R4936 T7005 T7008 arg1Of Comer,","
R4937 T7009 T7008 arg2Of 1998,","
R4938 T7010 T7004 arg3Of ),(
R4939 T7011 T7000 arg2Of ",",of
R4940 T7013 T7014 arg1Of IIα1,and
R4941 T7014 T7011 arg2Of and,","
R4942 T7014 T7012 arg1Of and,collagens
R4943 T7015 T7014 arg2Of VIα1,and
R4944 T7017 T7016 arg2Of Sun,(
R4945 T7017 T7018 arg1Of Sun,et
R4946 T7017 T7019 arg1Of Sun,al.
R4947 T7017 T7020 arg1Of Sun,","
R4948 T7021 T7020 arg2Of 1999,","
R4949 T7022 T7016 arg3Of ),(
R4950 T7024 T6996 arg2Of and,via
R4951 T7024 T7023 arg1Of and,","
R4952 T7026 T7024 arg2Of others,and
R4953 T7026 T7025 arg1Of others,many
R5250 T7622 T7620 arg1Of nine,At
R5251 T7622 T7621 arg1Of nine,least
R5252 T7623 T7622 arg1Of isoforms,nine
R5253 T7623 T7624 arg1Of isoforms,of
R5254 T7623 T7626 arg1Of isoforms,have
R5255 T7623 T7627 arg1Of isoforms,been
R5256 T7623 T7628 arg2Of isoforms,identified
R5257 T7625 T7624 arg2Of p53,of
R5258 T7628 T7626 arg2Of identified,have
R5259 T7628 T7627 arg2Of identified,been
R5260 T7628 T7630 arg1Of identified,to
R5261 T7628 T7645 arg1Of identified,(
R5262 T7630 T7629 arg1Of to,due
R5263 T7633 T7631 arg1Of splicing,alternative
R5264 T7633 T7632 arg1Of splicing,mRNA
R5265 T7633 T7634 arg1Of splicing,","
R5266 T7634 T7639 arg1Of ",",and
R5267 T7637 T7634 arg2Of promoters,","
R5268 T7637 T7635 arg1Of promoters,multiple
R5269 T7637 T7636 arg1Of promoters,gene
R5270 T7639 T7630 arg2Of and,to
R5271 T7639 T7638 arg1Of and,","
R5272 T7642 T7639 arg2Of sites,and
R5273 T7642 T7640 arg1Of sites,alternative
R5274 T7642 T7641 arg1Of sites,initiation
R5275 T7642 T7643 arg1Of sites,of
R5276 T7644 T7643 arg2Of translation,of
R5277 T7646 T7645 arg2Of Ghosh,(
R5278 T7646 T7647 arg1Of Ghosh,et
R5279 T7646 T7648 arg1Of Ghosh,al.
R5280 T7646 T7649 arg1Of Ghosh,","
R5281 T7646 T7651 arg1Of Ghosh,;
R5282 T7646 T7657 arg1Of Ghosh,;
R5283 T7650 T7649 arg2Of 2004,","
R5284 T7652 T7653 arg1Of Ray,et
R5285 T7652 T7654 arg1Of Ray,al.
R5286 T7652 T7655 arg1Of Ray,","
R5287 T7655 T7651 arg2Of ",",;
R5288 T7656 T7655 arg2Of 2006,","
R5289 T7658 T7657 arg2Of Figure,;
R5290 T7658 T7659 arg1Of Figure,2
R5291 T7660 T7645 arg3Of ),(
R5292 T7662 T7661 arg2Of cancers,In
R5293 T7665 T7664 arg1Of expression,aberrant
R5294 T7665 T7666 arg1Of expression,of
R5295 T7665 T7669 arg1Of expression,occurs
R5296 T7668 T7666 arg2Of isoforms,of
R5297 T7668 T7667 arg1Of isoforms,p53
R5298 T7669 T7661 arg1Of occurs,In
R5299 T7669 T7663 arg1Of occurs,","
R5300 T7669 T7670 arg1Of occurs,frequently
R5301 T7669 T7671 arg1Of occurs,(
R5302 T7672 T7671 arg2Of Bourdon,(
R5303 T7672 T7673 arg1Of Bourdon,et
R5304 T7672 T7674 arg1Of Bourdon,al.
R5305 T7672 T7675 arg1Of Bourdon,","
R5306 T7672 T7677 arg1Of Bourdon,;
R5307 T7676 T7675 arg2Of 2005,","
R5308 T7678 T7677 arg2Of Bourdon,;
R5309 T7678 T7679 arg1Of Bourdon,","
R5310 T7680 T7679 arg2Of 2007,","
R5311 T7681 T7671 arg3Of ),(
R5312 T7683 T7682 arg1Of p53,Full-length
R5313 T7683 T7684 arg1Of p53,","
R5314 T7684 T7687 arg1Of ",",and
R5315 T7685 T7684 arg2Of Δ133p53,","
R5316 T7687 T7686 arg1Of and,","
R5317 T7687 T7689 arg1Of and,are
R5318 T7687 T7690 arg2Of and,localized
R5319 T7688 T7687 arg2Of p53β,and
R5320 T7690 T7689 arg2Of localized,are
R5321 T7690 T7692 arg1Of localized,in
R5322 T7690 T7696 arg1Of localized,and
R5323 T7692 T7691 arg1Of in,mainly
R5324 T7694 T7692 arg2Of nucleus,in
R5325 T7694 T7693 arg1Of nucleus,the
R5326 T7696 T7695 arg1Of and,","
R5327 T7696 T7720 arg1Of and,(
R5328 T7698 T7697 arg1Of few,only
R5329 T7698 T7699 arg1Of few,of
R5330 T7698 T7701 arg1Of few,are
R5331 T7698 T7702 arg1Of few,in
R5332 T7700 T7699 arg2Of them,of
R5333 T7701 T7705 arg1Of are,and
R5334 T7702 T7701 arg2Of in,are
R5335 T7704 T7702 arg2Of p53γ,in
R5336 T7704 T7703 arg1Of p53γ,cytoplasm.
R5337 T7705 T7696 arg2Of and,and
R5338 T7706 T7707 arg1Of Δ133p53β,are
R5339 T7706 T7708 arg2Of Δ133p53β,localized
R5340 T7708 T7707 arg2Of localized,are
R5341 T7708 T7709 arg1Of localized,in
R5342 T7708 T7712 arg1Of localized,and
R5343 T7711 T7709 arg2Of nucleus,in
R5344 T7711 T7710 arg1Of nucleus,the
R5345 T7712 T7705 arg2Of and,and
R5346 T7714 T7713 arg1Of Δ133p53γ,cytoplasm.
R5347 T7714 T7715 arg1Of Δ133p53γ,is
R5348 T7714 T7716 arg1Of Δ133p53γ,localized
R5349 T7715 T7712 arg2Of is,and
R5350 T7716 T7715 arg2Of localized,is
R5351 T7716 T7717 arg1Of localized,in
R5352 T7719 T7717 arg2Of cytoplasm,in
R5353 T7719 T7718 arg1Of cytoplasm,the
R5354 T7721 T7720 arg2Of Bourdon,(
R5355 T7721 T7722 arg1Of Bourdon,et
R5356 T7721 T7723 arg1Of Bourdon,al.
R5357 T7721 T7724 arg1Of Bourdon,","
R5358 T7725 T7724 arg2Of 2005,","
R5359 T7726 T7720 arg3Of ),(
R5360 T7727 T7728 arg1Of Co-transfection,of
R5361 T7727 T7732 arg1Of Co-transfection,increases
R5362 T7729 T7730 arg1Of p53,and
R5363 T7730 T7728 arg2Of and,of
R5364 T7731 T7730 arg2Of p53β,and
R5365 T7732 T7736 arg1Of increases,whereas
R5366 T7734 T7732 arg2Of apoptosis,increases
R5367 T7734 T7733 arg1Of apoptosis,p53-mediated
R5368 T7736 T7735 arg1Of whereas,","
R5369 T7737 T7738 arg1Of co-expression,of
R5370 T7737 T7740 arg1Of co-expression,with
R5371 T7737 T7742 arg1Of co-expression,suppresses
R5372 T7739 T7738 arg2Of p53,of
R5373 T7741 T7740 arg2Of Δ133p53,with
R5374 T7742 T7736 arg2Of suppresses,whereas
R5375 T7742 T7745 arg1Of suppresses,(
R5376 T7744 T7742 arg2Of apoptosis,suppresses
R5377 T7744 T7743 arg1Of apoptosis,p53-mediated
R5378 T7746 T7745 arg2Of Bourdon,(
R5379 T7746 T7747 arg1Of Bourdon,et
R5380 T7746 T7748 arg1Of Bourdon,al.
R5381 T7746 T7749 arg1Of Bourdon,","
R5382 T7750 T7749 arg2Of 2005,","
R5383 T7751 T7745 arg3Of ),(
R5384 T7752 T7754 arg1Of . Δ133p,lly regul
R5385 T7754 T7742 arg3Of lly regul,suppresses
R5386 T7754 T7753 arg1Of lly regul,53 differentia
R5387 T7756 T7754 arg2Of gene expre,lly regul
R5388 T7756 T7755 arg1Of gene expre,ates
R5389 T7756 T7757 arg1Of gene expre,ss
R5390 T7758 T7759 arg1Of ion in p53-de,pen
R5396 T7763 T7762 arg2Of t manne,n
R5397 T7763 T7764 arg1Of t manne,rs
R5398 T7763 T7765 arg1Of t manne,(Ao
R5399 T7763 T7766 arg1Of t manne,u
R5400 T7767 T7766 arg2Of bala,u
R5401 T7768 T7762 arg3Of e,n
R5402 T7769 T7770 arg1Of Co-expression,of
R5403 T7769 T7774 arg1Of Co-expression,with
R5404 T7769 T7776 arg1Of Co-expression,does
R5405 T7769 T7778 arg1Of Co-expression,affect
R5406 T7771 T7772 arg1Of Δ133p53β,or
R5407 T7772 T7770 arg2Of or,of
R5408 T7773 T7772 arg2Of Δ133p53γ,or
R5409 T7775 T7774 arg2Of p53,with
R5410 T7778 T7776 arg2Of affect,does
R5411 T7778 T7777 arg1Of affect,not
R5412 T7781 T7779 arg1Of activity,p53
R5413 T7781 T7780 arg1Of activity,transcriptional
R5414 T7781 T7782 arg1Of activity,on
R5415 T7781 T7790 arg1Of activity,as
R5416 T7783 T7784 arg1Of p21,and
R5417 T7785 T7784 arg2Of Bax,and
R5418 T7786 T7782 arg2Of promoters,on
R5419 T7786 T7783 arg1Of promoters,p21
R5420 T7786 T7785 arg1Of promoters,Bax
R5421 T7790 T7778 arg2Of as,affect
R5422 T7790 T7787 arg1Of as,","
R5423 T7790 T7788 arg1Of as,as
R5424 T7790 T7789 arg1Of as,well
R5425 T7791 T7790 arg2Of apoptosis,as
R5812 T8541 T8540 arg1Of mutants,p53
R5813 T8541 T8542 arg1Of mutants,are
R5814 T8541 T8543 arg2Of mutants,considered
R5815 T8543 T8542 arg2Of considered,are
R5816 T8543 T8544 arg1Of considered,as
R5817 T8543 T8555 arg1Of considered,in
R5818 T8546 T8544 arg2Of factors,as
R5819 T8546 T8545 arg1Of factors,unfavorable
R5820 T8546 T8547 arg1Of factors,for
R5821 T8549 T8547 arg2Of effectiveness,for
R5822 T8549 T8548 arg1Of effectiveness,the
R5823 T8549 T8550 arg1Of effectiveness,in
R5824 T8551 T8552 arg1Of radiotherapy,and
R5825 T8553 T8552 arg2Of TMZ,and
R5826 T8554 T8550 arg2Of treatment,in
R5827 T8554 T8551 arg1Of treatment,radiotherapy
R5828 T8554 T8553 arg1Of treatment,TMZ
R5829 T8557 T8555 arg2Of cells,in
R5830 T8557 T8556 arg1Of cells,glioma
R5831 T8557 T8558 arg1Of cells,(
R5832 T8559 T8560 arg1Of Gjerset,et
R5833 T8559 T8561 arg1Of Gjerset,al.
R5834 T8559 T8562 arg1Of Gjerset,","
R5835 T8562 T8558 arg2Of ",",(
R5836 T8562 T8564 arg1Of ",",;
R5837 T8562 T8570 arg1Of ",",;
R5838 T8563 T8562 arg2Of 1995,","
R5839 T8565 T8564 arg2Of Hirose,;
R5840 T8565 T8566 arg1Of Hirose,et
R5841 T8565 T8567 arg1Of Hirose,al.
R5842 T8565 T8568 arg1Of Hirose,","
R5843 T8569 T8568 arg2Of 2001,","
R5844 T8571 T8570 arg2Of Squatrito,;
R5845 T8571 T8572 arg1Of Squatrito,et
R5846 T8571 T8573 arg1Of Squatrito,al.
R5847 T8571 T8574 arg1Of Squatrito,","
R5848 T8571 T8576 arg1Of Squatrito,;
R5849 T8575 T8574 arg2Of 2010,","
R5850 T8577 T8576 arg2Of Blough,;
R5851 T8577 T8578 arg1Of Blough,et
R5852 T8577 T8579 arg1Of Blough,al.
R5853 T8577 T8580 arg1Of Blough,","
R5854 T8581 T8580 arg2Of 2011,","
R5855 T8582 T8558 arg3Of ),(
R5856 T8583 T8584 arg1Of Loss,of
R5857 T8583 T8587 arg1Of Loss,confers
R5858 T8586 T8584 arg2Of p53,of
R5859 T8586 T8585 arg1Of p53,functional
R5860 T8587 T8589 arg1Of confers,to
R5861 T8587 T8591 arg1Of confers,in
R5862 T8587 T8595 arg1Of confers,whereas
R5863 T8588 T8587 arg2Of sensitivity,confers
R5864 T8590 T8589 arg2Of TMZ,to
R5865 T8593 T8591 arg2Of cells,in
R5866 T8593 T8592 arg1Of cells,glioma
R5867 T8595 T8594 arg1Of whereas,","
R5868 T8598 T8596 arg1Of p53,wild
R5869 T8598 T8597 arg1Of p53,type
R5870 T8598 T8599 arg1Of p53,increases
R5871 T8599 T8595 arg2Of increases,whereas
R5872 T8602 T8599 arg2Of resistance,increases
R5873 T8602 T8600 arg1Of resistance,the
R5874 T8602 T8601 arg1Of resistance,TMZ
R5875 T8602 T8603 arg1Of resistance,(
R5876 T8602 T8612 arg2Of resistance,nts re
R5877 T8602 T8615 arg1Of resistance,ti
R5878 T8604 T8603 arg2Of Blough,(
R5879 T8604 T8605 arg1Of Blough,et
R5880 T8604 T8606 arg1Of Blough,al.
R5881 T8604 T8607 arg1Of Blough,","
R5882 T8608 T8607 arg2Of 2011,","
R5883 T8609 T8603 arg3Of ),(
R5884 T8611 T8610 arg1Of 53 muta,. p
R5885 T8611 T8612 arg1Of 53 muta,nts re
R5886 T8614 T8612 arg3Of e TMZ sensi,nts re
R5887 T8614 T8613 arg1Of e TMZ sensi,duc
R5888 T8616 T8615 arg2Of vity in,ti
R5889 T8616 T8617 arg1Of vity in,g
R5890 T8618 T8617 arg2Of liomas,g
R5891 T8618 T8619 arg1Of liomas,(B
R5892 T8618 T8620 arg1Of liomas,lou
R5893 T8618 T8621 arg1Of liomas,g
R5894 T8622 T8621 arg2Of h et,g
R5895 T8623 T8617 arg3Of a,g
R5896 T8626 T8624 arg2Of expression,Altered
R5897 T8626 T8625 arg1Of expression,WWOX
R5898 T8626 T8627 arg1Of expression,is
R5899 T8626 T8628 arg2Of expression,shown
R5900 T8628 T8627 arg2Of shown,is
R5901 T8628 T8629 arg1Of shown,in
R5902 T8630 T8629 arg2Of GBMs,in
R5903 T8630 T8632 arg2Of GBMs,in
R5904 T8630 T8633 arg1Of GBMs,which
R5905 T8634 T8635 arg1Of downregulation,of
R5906 T8634 T8637 arg1Of downregulation,is
R5907 T8634 T8638 arg2Of downregulation,associated
R5908 T8636 T8635 arg2Of WWOX,of
R5909 T8638 T8631 arg1Of associated,","
R5910 T8638 T8632 arg1Of associated,in
R5911 T8638 T8637 arg2Of associated,is
R5912 T8638 T8639 arg1Of associated,with
R5913 T8640 T8639 arg2Of loss,with
R5914 T8640 T8641 arg1Of loss,of
R5915 T8642 T8643 arg1Of heterozygosity,and
R5916 T8644 T8643 arg2Of promoter,and
R5917 T8645 T8641 arg2Of methylation,of
R5918 T8645 T8642 arg1Of methylation,heterozygosity
R5919 T8645 T8644 arg1Of methylation,promoter
R5920 T8645 T8646 arg1Of methylation,(
R5921 T8647 T8646 arg2Of Kosla,(
R5922 T8647 T8648 arg1Of Kosla,et
R5923 T8647 T8649 arg1Of Kosla,al.
R5924 T8647 T8650 arg1Of Kosla,","
R5925 T8651 T8650 arg2Of 2011,","
R5926 T8652 T8646 arg3Of ),(
R5927 T8655 T8656 arg1Of we,demonstrated
R5928 T8656 T8653 arg1Of demonstrated,Recently
R5929 T8656 T8654 arg1Of demonstrated,","
R5930 T8659 T8658 arg2Of WWOX,overexpressed
R5931 T8659 T8660 arg1Of WWOX,induces
R5932 T8659 T8670 arg1Of WWOX,causing
R5933 T8660 T8656 arg2Of induces,demonstrated
R5934 T8660 T8657 arg1Of induces,that
R5935 T8660 T8669 arg1Of induces,by
R5936 T8661 T8660 arg2Of apoptosis,induces
R5937 T8661 T8662 arg1Of apoptosis,of
R5938 T8665 T8662 arg2Of cells,of
R5939 T8665 T8663 arg1Of cells,glioblastoma
R5940 T8665 T8664 arg1Of cells,U373-MG
R5941 T8665 T8666 arg1Of cells,harboring
R5942 T8668 T8666 arg2Of p53,harboring
R5943 T8668 T8667 arg1Of p53,mutant
R5944 T8670 T8669 arg2Of causing,by
R5945 T8670 T8675 arg1Of causing,(
R5946 T8671 T8672 arg1Of hypoploidy,and
R5947 T8672 T8670 arg2Of and,causing
R5948 T8674 T8672 arg2Of fragmentation,and
R5949 T8674 T8673 arg1Of fragmentation,DNA
R5950 T8676 T8675 arg2Of Chiang,(
R5951 T8676 T8677 arg1Of Chiang,et
R5952 T8676 T8678 arg1Of Chiang,al.
R5953 T8676 T8679 arg1Of Chiang,","
R5954 T8680 T8679 arg2Of 2012,","
R5955 T8681 T8675 arg3Of ),(
R5956 T8685 T8684 arg1Of WWOX,ectopic
R5957 T8685 T8686 arg1Of WWOX,has
R5958 T8686 T8682 arg1Of has,However
R5959 T8686 T8683 arg1Of has,","
R5960 T8688 T8686 arg2Of effect,has
R5961 T8688 T8687 arg1Of effect,no
R5962 T8688 T8689 arg1Of effect,with
R5963 T8690 T8689 arg2Of U87-MG,with
R5964 T8690 T8691 arg1Of U87-MG,expressing
R5965 T8694 T8691 arg2Of p53,expressing
R5966 T8694 T8692 arg1Of p53,wild
R5967 T8694 T8693 arg1Of p53,type
R5968 T8696 T8695 arg2Of TMZ,Unlike
R5969 T8698 T8699 arg1Of WWOX,induces
R5970 T8699 T8695 arg1Of induces,Unlike
R5971 T8699 T8697 arg1Of induces,","
R5972 T8699 T8704 arg1Of induces,via
R5973 T8700 T8699 arg2Of apoptosis,induces
R5974 T8700 T8701 arg1Of apoptosis,of
R5975 T8703 T8701 arg2Of cells,of
R5976 T8703 T8702 arg1Of cells,U373-MG
R5977 T8706 T8707 arg1Of mitochondria-independent,and
R5978 T8708 T8707 arg2Of caspase-3-independent,and
R5979 T8709 T8704 arg2Of pathway,via
R5980 T8709 T8705 arg1Of pathway,a
R5981 T8709 T8706 arg1Of pathway,mitochondria-independent
R5982 T8709 T8708 arg1Of pathway,caspase-3-independent
R5983 T8709 T8710 arg1Of pathway,(
R5984 T8711 T8710 arg2Of Chiang,(
R5985 T8711 T8712 arg1Of Chiang,et
R5986 T8711 T8713 arg1Of Chiang,al.
R5987 T8711 T8714 arg1Of Chiang,","
R5988 T8715 T8714 arg2Of 2012,","
R5989 T8716 T8710 arg3Of ),(
R5990 T8720 T8718 arg1Of mechanisms,the
R5991 T8720 T8719 arg1Of mechanisms,underlying
R5992 T8720 T8721 arg1Of mechanisms,are
R5993 T8720 T8722 arg1Of mechanisms,unknown
R5994 T8721 T8717 arg2Of are,While
R5995 T8722 T8721 arg2Of unknown,are
R5996 T8725 T8717 arg1Of is,While
R5997 T8725 T8723 arg1Of is,","
R5998 T8726 T8725 arg2Of reasonable,is
R5999 T8728 T8724 arg1Of assume,it
R6000 T8728 T8725 arg1Of assume,is
R6001 T8728 T8726 arg1Of assume,reasonable
R6002 T8728 T8727 arg1Of assume,to
R6003 T8731 T8730 arg1Of survival,the
R6004 T8731 T8732 arg1Of survival,of
R6005 T8731 T8736 arg1Of survival,depends
R6006 T8735 T8732 arg2Of cells,of
R6007 T8735 T8733 arg1Of cells,human
R6008 T8735 T8734 arg1Of cells,glioblastoma
R6009 T8736 T8728 arg2Of depends,assume
R6010 T8736 T8729 arg1Of depends,that
R6011 T8736 T8737 arg1Of depends,upon
R6012 T8738 T8737 arg2Of interactions,upon
R6013 T8738 T8739 arg1Of interactions,between
R6014 T8741 T8739 arg2Of gain-of-function,between
R6015 T8741 T8740 arg1Of gain-of-function,the
R6016 T8741 T8742 arg1Of gain-of-function,of
R6017 T8744 T8743 arg1Of mutants,p53
R6018 T8744 T8745 arg1Of mutants,and
R6019 T8745 T8742 arg2Of and,of
R6020 T8746 T8745 arg2Of WWOX,and
R6021 T8748 T8747 arg2Of WWOX,Activated
R6022 T8748 T8749 arg1Of WWOX,binds
R6023 T8749 T8756 arg1Of binds,(
R6024 T8752 T8749 arg2Of p53,binds
R6025 T8752 T8750 arg1Of p53,wild
R6026 T8752 T8751 arg1Of p53,type
R6027 T8752 T8753 arg1Of p53,with
R6028 T8755 T8753 arg2Of phosphorylation,with
R6029 T8755 T8754 arg1Of phosphorylation,Ser46
R6030 T8757 T8756 arg2Of Chang,(
R6031 T8757 T8758 arg1Of Chang,et
R6032 T8757 T8759 arg1Of Chang,al.
R6033 T8757 T8760 arg1Of Chang,","
R6034 T8761 T8760 arg2Of 2005b,","
R6035 T8762 T8756 arg3Of ),(
R6036 T8764 T8763 arg1Of irradiation,UV
R6037 T8764 T8765 arg1Of irradiation,enhances
R6038 T8768 T8765 arg2Of interactions,enhances
R6039 T8768 T8766 arg1Of interactions,the
R6040 T8768 T8767 arg1Of interactions,binding
R6041 T8771 T8769 arg2Of presence,Despite
R6042 T8771 T8770 arg1Of presence,the
R6043 T8771 T8772 arg1Of presence,of
R6044 T8771 T8774 arg1Of presence,in
R6045 T8773 T8772 arg2Of Ser46,of
R6046 T8775 T8774 arg2Of Δ40p53,in
R6047 T8777 T8778 arg1Of binding,of
R6048 T8777 T8783 arg1Of binding,remains
R6049 T8777 T8785 arg1Of binding,be
R6050 T8777 T8786 arg2Of binding,determined
R6051 T8780 T8778 arg2Of protein,of
R6052 T8780 T8779 arg1Of protein,this
R6053 T8780 T8781 arg1Of protein,with
R6054 T8782 T8781 arg2Of WWOX,with
R6055 T8783 T8769 arg1Of remains,Despite
R6056 T8783 T8776 arg1Of remains,","
R6059 T8786 T8785 arg2Of determined,be
R6060 T8787 T8788 arg1Of We,postulate
R6061 T8792 T8790 arg2Of cells,in
R6062 T8792 T8791 arg1Of cells,GBM
R6063 T8801 T8794 arg1Of proteins,both
R6064 T8801 T8795 arg1Of proteins,wild
R6065 T8801 T8796 arg1Of proteins,type
R6066 T8801 T8797 arg1Of proteins,p53
R6067 T8801 T8798 arg1Of proteins,and
R6068 T8801 T8799 arg1Of proteins,ectopic
R6069 T8801 T8800 arg1Of proteins,WWOX
R6070 T8801 T8802 arg1Of proteins,appear
R6071 T8801 T8804 arg1Of proteins,have
R6072 T8801 T8810 arg1Of proteins,nullifying
R6073 T8802 T8788 arg2Of appear,postulate
R6074 T8802 T8789 arg1Of appear,that
R6075 T8802 T8790 arg1Of appear,in
R6076 T8802 T8793 arg1Of appear,","
R6077 T8804 T8802 arg2Of have,appear
R6078 T8804 T8803 arg1Of have,to
R6079 T8804 T8808 arg1Of have,","
R6080 T8807 T8804 arg2Of antagonism,have
R6081 T8807 T8805 arg1Of antagonism,a
R6082 T8807 T8806 arg1Of antagonism,functional
R6083 T8810 T8804 arg3Of nullifying,have
R6084 T8810 T8809 arg1Of nullifying,thereby
R6085 T8812 T8811 arg1Of other’s,each
R6086 T8812 T8813 arg1Of other’s,function
R6087 T8812 T8815 arg1Of other’s,inducing
R6088 T8813 T8810 arg2Of function,nullifying
R6089 T8813 T8814 arg1Of function,in
R6090 T8815 T8814 arg2Of inducing,in
R6091 T8816 T8815 arg2Of apoptosis,inducing
R6092 T8816 T8817 arg1Of apoptosis,(
R6093 T8818 T8817 arg2Of Figure,(
R6094 T8818 T8819 arg1Of Figure,2
R6095 T8820 T8817 arg3Of ),(
R6096 T8823 T8821 arg1Of proteins,Mutant
R6097 T8823 T8822 arg1Of proteins,p53
R6098 T8823 T8824 arg1Of proteins,can
R6099 T8823 T8826 arg1Of proteins,bind
R6100 T8826 T8824 arg2Of bind,can
R6101 T8826 T8825 arg1Of bind,not
R6102 T8826 T8829 arg1Of bind,in
R6103 T8826 T8833 arg1Of bind,and
R6104 T8828 T8826 arg2Of WWOX,bind
R6105 T8828 T8827 arg1Of WWOX,ectopic
R6106 T8831 T8829 arg2Of cells,in
R6107 T8831 T8830 arg1Of cells,GBM
R6108 T8833 T8832 arg1Of and,","
R6109 T8834 T8835 arg1Of WWOX,is
R6110 T8834 T8836 arg1Of WWOX,able
R6111 T8834 T8838 arg1Of WWOX,induce
R6112 T8835 T8833 arg2Of is,and
R6113 T8836 T8835 arg2Of able,is
R6114 T8838 T8836 arg2Of induce,able
R6115 T8838 T8837 arg1Of induce,to
R6116 T8839 T8838 arg2Of apoptosis,induce
R6117 T8841 T8842 arg1Of WWOX,causes
R6118 T8842 T8840 arg1Of causes,Whether
R6119 T8842 T8844 arg1Of causes,in
R6120 T8842 T8849 arg1Of causes,is
R6121 T8842 T8850 arg1Of causes,unknown
R6122 T8842 T8852 arg1Of causes,remains
R6123 T8842 T8854 arg1Of causes,be
R6124 T8842 T8855 arg2Of causes,established
R6125 T8843 T8842 arg2Of apoptosis,causes
R6126 T8848 T8844 arg2Of isoforms,in
R6127 T8848 T8845 arg1Of isoforms,GBM
R6128 T8848 T8846 arg1Of isoforms,expressing
R6129 T8848 T8847 arg1Of isoforms,p53
R6130 T8849 T8851 arg1Of is,and
R6131 T8850 T8849 arg2Of unknown,is
R6132 T8852 T8851 arg2Of remains,and
R6133 T8855 T8852 arg2Of established,remains
R6134 T8855 T8853 arg1Of established,to
R6135 T8855 T8854 arg2Of established,be
R6669 T10070 T10071 arg1Of WWOX,affects
R6670 T10071 T10069 arg1Of affects,Whether
R6671 T10071 T10074 arg1Of affects,has
R6672 T10071 T10076 arg1Of affects,been
R6673 T10071 T10077 arg2Of affects,determined
R6674 T10073 T10071 arg2Of sensitivity,affects
R6675 T10073 T10072 arg1Of sensitivity,TMZ
R6676 T10077 T10074 arg2Of determined,has
R6677 T10077 T10075 arg1Of determined,never
R6678 T10077 T10076 arg2Of determined,been
R6679 T10079 T10078 arg1Of proteins,Binding
R6680 T10079 T10080 arg1Of proteins,for
R6681 T10079 T10084 arg1Of proteins,are
R6682 T10079 T10085 arg1Of proteins,likely
R6683 T10081 T10082 arg1Of WWOX,and/or
R6684 T10082 T10080 arg2Of and/or,for
R6685 T10083 T10082 arg2Of p53,and/or
R6686 T10085 T10084 arg2Of likely,are
R6687 T10087 T10085 arg2Of affect,likely
R6688 T10087 T10086 arg1Of affect,to
R6689 T10088 T10089 arg1Of apoptosis,and
R6690 T10089 T10087 arg2Of and,affect
R6691 T10089 T10092 arg1Of and,in
R6692 T10091 T10089 arg2Of sensitivity,and
R6693 T10091 T10090 arg1Of sensitivity,TMZ
R6694 T10094 T10092 arg2Of cells,in
R6695 T10094 T10093 arg1Of cells,GBM
R6696 T10095 T10096 arg1Of WWOX,binds
R6697 T10096 T10099 arg1Of binds,and
R6698 T10097 T10096 arg2Of MEK,binds
R6699 T10099 T10098 arg1Of and,","
R6700 T10101 T10102 arg1Of PMA,dissociates
R6701 T10102 T10099 arg2Of dissociates,and
R6702 T10102 T10100 arg1Of dissociates,that
R6703 T10104 T10102 arg2Of complex,dissociates
R6704 T10104 T10103 arg1Of complex,this
R6705 T10104 T10105 arg1Of complex,for
R6706 T10106 T10105 arg2Of causing,for
R6707 T10106 T10112 arg1Of causing,(
R6708 T10107 T10106 arg2Of apoptosis,causing
R6709 T10107 T10108 arg1Of apoptosis,of
R6710 T10111 T10108 arg2Of cells,of
R6711 T10111 T10109 arg1Of cells,T
R6712 T10111 T10110 arg1Of cells,leukemia
R6713 T10113 T10112 arg2Of Lin,(
R6714 T10113 T10114 arg1Of Lin,et
R6715 T10113 T10115 arg1Of Lin,al.
R6716 T10113 T10116 arg1Of Lin,","
R6717 T10117 T10116 arg2Of 2011,","
R6718 T10118 T10112 arg3Of ),(
R6719 T10122 T10121 arg1Of chemicals,appropriate
R6720 T10122 T10123 arg1Of chemicals,","
R6721 T10122 T10124 arg1Of chemicals,which
R6722 T10122 T10125 arg1Of chemicals,break
R6723 T10122 T10131 arg1Of chemicals,are
R6724 T10122 T10132 arg2Of chemicals,expected
R6725 T10122 T10134 arg1Of chemicals,cause
R6726 T10125 T10126 arg1Of break,apart
R6727 T10129 T10125 arg2Of complex,break
R6728 T10129 T10127 arg1Of complex,the
R6729 T10129 T10128 arg1Of complex,WWOX/MEK
R6730 T10132 T10119 arg1Of expected,Thus
R6731 T10132 T10120 arg1Of expected,","
R6732 T10132 T10130 arg1Of expected,","
R6733 T10132 T10131 arg2Of expected,are
R6734 T10134 T10132 arg3Of cause,expected
R6735 T10134 T10133 arg1Of cause,to
R6736 T10137 T10134 arg2Of death,cause
R6737 T10137 T10135 arg1Of death,GBM
R6738 T10137 T10136 arg1Of death,cell
R6739 T10139 T10138 arg1Of studies,Preliminary
R6740 T10139 T10140 arg1Of studies,from
R6741 T10139 T10145 arg1Of studies,have
R6742 T10139 T10146 arg1Of studies,selected
R6743 T10142 T10140 arg2Of screening,from
R6744 T10142 T10141 arg1Of screening,our
R6745 T10142 T10143 arg1Of screening,of
R6746 T10144 T10143 arg2Of chemicals,of
R6747 T10146 T10145 arg2Of selected,have
R6748 T10149 T10146 arg2Of molecules,selected
R6749 T10149 T10147 arg1Of molecules,certain
R6750 T10149 T10148 arg1Of molecules,small
R6751 T10149 T10150 arg1Of molecules,that
R6752 T10149 T10151 arg1Of molecules,induce
R6753 T10152 T10151 arg2Of apoptosis,induce
R6754 T10152 T10153 arg1Of apoptosis,of
R6755 T10155 T10153 arg2Of types,of
R6756 T10155 T10154 arg1Of types,many
R6757 T10155 T10156 arg1Of types,of
R6758 T10155 T10159 arg1Of types,(
R6759 T10158 T10156 arg2Of cells,of
R6760 T10158 T10157 arg1Of cells,cancer
R6761 T10162 T10159 arg2Of al.,(
R6762 T10162 T10160 arg1Of al.,Lu
R6763 T10162 T10161 arg1Of al.,et
R6764 T10162 T10163 arg1Of al.,","
R6765 T10164 T10163 arg2Of unpublished,","
R6766 T10165 T10159 arg3Of ),(
R6767 T10169 T10168 arg1Of inhibition,specific
R6768 T10169 T10170 arg1Of inhibition,of
R6769 T10169 T10172 arg1Of inhibition,by
R6770 T10169 T10174 arg1Of inhibition,enhances
R6771 T10171 T10170 arg2Of MEK,of
R6772 T10173 T10172 arg2Of selumetinib,by
R6773 T10174 T10166 arg1Of enhances,Indeed
R6774 T10174 T10167 arg1Of enhances,","
R6775 T10174 T10181 arg1Of enhances,(
R6776 T10178 T10174 arg2Of death,enhances
R6777 T10178 T10175 arg1Of death,TMZ-induced
R6778 T10178 T10176 arg1Of death,cancer
R6779 T10178 T10177 arg1Of death,cell
R6780 T10178 T10180 arg1Of death,vivo
R6781 T10180 T10179 arg1Of vivo,in
R6782 T10182 T10181 arg2Of Holt,(
R6783 T10182 T10183 arg1Of Holt,et
R6784 T10182 T10184 arg1Of Holt,al.
R6785 T10182 T10185 arg1Of Holt,","
R6786 T10186 T10185 arg2Of 2012,","
R6787 T10187 T10181 arg3Of ),(
R6788 T10189 T10188 arg1Of factors,Serum
R6789 T10189 T10190 arg1Of factors,can
R6790 T10189 T10191 arg1Of factors,be
R6791 T10189 T10192 arg2Of factors,utilized
R6792 T10192 T10190 arg2Of utilized,can
R6793 T10192 T10191 arg2Of utilized,be
R6794 T10192 T10193 arg1Of utilized,for
R6795 T10194 T10193 arg2Of blocking,for
R6796 T10196 T10194 arg2Of growth,blocking
R6797 T10196 T10195 arg1Of growth,cancer
R6798 T10198 T10197 arg2Of example,For
R6799 T10202 T10200 arg1Of C1q,serum
R6800 T10202 T10201 arg1Of C1q,complement
R6801 T10202 T10203 arg1Of C1q,induces
R6802 T10203 T10197 arg1Of induces,For
R6803 T10203 T10199 arg1Of induces,","
R6804 T10204 T10203 arg2Of apoptosis,induces
R6805 T10204 T10205 arg1Of apoptosis,of
R6806 T10204 T10211 arg1Of apoptosis,without
R6807 T10207 T10206 arg1Of cancer,prostate
R6808 T10207 T10208 arg1Of cancer,and
R6809 T10208 T10205 arg2Of and,of
R6810 T10210 T10208 arg2Of cells,and
R6811 T10210 T10209 arg1Of cells,neuroblastomas
R6812 T10212 T10211 arg2Of participation,without
R6813 T10212 T10213 arg1Of participation,of
R6814 T10215 T10213 arg2Of proteins,of
R6815 T10215 T10214 arg1Of proteins,downstream
R6816 T10215 T10216 arg1Of proteins,in
R6817 T10220 T10216 arg2Of pathway,in
R6818 T10220 T10217 arg1Of pathway,the
R6819 T10220 T10218 arg1Of pathway,classical
R6820 T10220 T10219 arg1Of pathway,activation
R6821 T10220 T10221 arg1Of pathway,(
R6822 T10222 T10221 arg2Of Hong,(
R6823 T10222 T10223 arg1Of Hong,et
R6824 T10222 T10224 arg1Of Hong,al.
R6825 T10222 T10225 arg1Of Hong,","
R6826 T10226 T10225 arg2Of 2009,","
R6827 T10227 T10221 arg3Of ),(
R6828 T10230 T10228 arg2Of event,In
R6829 T10230 T10229 arg1Of event,this
R6830 T10233 T10232 arg1Of WWOX,ectopic
R6831 T10233 T10234 arg1Of WWOX,is
R6832 T10233 T10235 arg2Of WWOX,activated
R6833 T10233 T10237 arg1Of WWOX,inducing
R6834 T10235 T10228 arg1Of activated,In
R6835 T10235 T10231 arg1Of activated,","
R6836 T10235 T10234 arg2Of activated,is
R6837 T10235 T10236 arg1Of activated,for
R6838 T10237 T10236 arg2Of inducing,for
R6839 T10238 T10237 arg2Of apoptosis,inducing
R6840 T10239 T10240 arg1Of Failure,of
R6841 T10239 T10243 arg1Of Failure,in
R6842 T10239 T10253 arg1Of Failure,is
R6843 T10239 T10254 arg1Of Failure,unusual
R6844 T10242 T10240 arg2Of WWOX,of
R6845 T10242 T10241 arg1Of WWOX,ectopic
R6846 T10244 T10243 arg2Of inducing,in
R6847 T10245 T10244 arg2Of apoptosis,inducing
R6848 T10245 T10246 arg1Of apoptosis,of
R6849 T10248 T10246 arg2Of cells,of
R6850 T10248 T10247 arg1Of cells,glioma
R6851 T10248 T10249 arg1Of cells,possessing
R6852 T10252 T10249 arg2Of p53,possessing
R6853 T10252 T10250 arg1Of p53,wild
R6854 T10252 T10251 arg1Of p53,type
R6855 T10254 T10253 arg2Of unusual,is
R6856 T10254 T10255 arg1Of unusual,(
R6857 T10256 T10255 arg2Of Chiang,(
R6858 T10256 T10257 arg1Of Chiang,et
R6859 T10256 T10258 arg1Of Chiang,al.
R6860 T10256 T10259 arg1Of Chiang,","
R6861 T10260 T10259 arg2Of 2012,","
R6862 T10261 T10255 arg3Of ),(
R6863 T10264 T10262 arg2Of cases,In
R6864 T10264 T10263 arg1Of cases,most
R6865 T10266 T10267 arg1Of we,have
R6866 T10266 T10268 arg1Of we,shown
R6867 T10268 T10262 arg1Of shown,In
R6868 T10268 T10265 arg1Of shown,","
R6869 T10268 T10267 arg2Of shown,have
R6870 T10270 T10272 arg1Of p53,interacts
R6871 T10272 T10271 arg1Of interacts,functionally
R6872 T10272 T10273 arg1Of interacts,with
R6873 T10272 T10276 arg1Of interacts,and
R6874 T10274 T10273 arg2Of WWOX,with
R6875 T10276 T10268 arg2Of and,shown
R6876 T10276 T10269 arg1Of and,that
R6877 T10276 T10275 arg1Of and,","
R6878 T10278 T10277 arg1Of proteins,both
R6879 T10278 T10279 arg1Of proteins,induce
R6880 T10279 T10276 arg2Of induce,and
R6881 T10279 T10281 arg1Of induce,in
R6882 T10279 T10285 arg1Of induce,(
R6883 T10280 T10279 arg2Of apoptosis,induce
R6884 T10284 T10281 arg2Of manner,in
R6885 T10284 T10282 arg1Of manner,a
R6886 T10284 T10283 arg1Of manner,synergistic
R6887 T10286 T10287 arg1Of Chang,et
R6888 T10286 T10288 arg1Of Chang,al.
R6889 T10286 T10289 arg1Of Chang,","
R6890 T10289 T10291 arg1Of ",",","
R6891 T10290 T10289 arg2Of 2001,","
R6892 T10291 T10285 arg2Of ",",(
R6893 T10291 T10293 arg1Of ",",","
R6894 T10291 T10303 arg1Of ",",;
R6895 T10292 T10291 arg2Of 2003,","
R6896 T10294 T10295 arg1Of 2005a,","
R6897 T10295 T10297 arg1Of ",",","
R6898 T10296 T10295 arg2Of b,","
R6899 T10297 T10299 arg1Of ",",","
R6900 T10298 T10297 arg2Of 2007,","
R6901 T10299 T10301 arg1Of ",",","
R6902 T10300 T10299 arg2Of 2010,","
R6903 T10301 T10293 arg2Of ",",","
R6904 T10302 T10301 arg2Of 2012,","
R6905 T10304 T10303 arg2Of Su,;
R6906 T10304 T10305 arg1Of Su,et
R6907 T10304 T10306 arg1Of Su,al.
R6908 T10304 T10307 arg1Of Su,","
R6909 T10308 T10307 arg2Of 2012,","
R6910 T10309 T10285 arg3Of ),(
R6911 T10312 T10310 arg1Of scenario,A
R6912 T10312 T10311 arg1Of scenario,likely
R6913 T10312 T10313 arg1Of scenario,is
R6914 T10316 T10315 arg1Of proteins,p53-binding
R6915 T10316 T10317 arg1Of proteins,","
R6916 T10316 T10318 arg1Of proteins,which
R6917 T10316 T10319 arg1Of proteins,are
R6918 T10316 T10320 arg1Of proteins,present
R6919 T10316 T10324 arg1Of proteins,may
R6920 T10316 T10325 arg1Of proteins,interfere
R6921 T10320 T10319 arg2Of present,are
R6922 T10320 T10321 arg1Of present,in
R6923 T10322 T10321 arg2Of GBMs,in
R6924 T10325 T10313 arg2Of interfere,is
R6925 T10325 T10314 arg1Of interfere,that
R6926 T10325 T10323 arg1Of interfere,","
R6927 T10325 T10324 arg2Of interfere,may
R6928 T10325 T10326 arg1Of interfere,with
R6929 T10329 T10326 arg2Of function,with
R6930 T10329 T10327 arg1Of function,the
R6931 T10329 T10328 arg1Of function,apoptotic
R6932 T10329 T10330 arg1Of function,of
R6933 T10331 T10332 arg1Of WWOX,and
R6934 T10332 T10330 arg2Of and,of
R6935 T10333 T10332 arg2Of p53,and
R6936 T10335 T10334 arg1Of antagonism,Functional
R6937 T10335 T10336 arg1Of antagonism,among
R6938 T10335 T10339 arg1Of antagonism,has
R6939 T10335 T10341 arg1Of antagonism,been
R6940 T10335 T10342 arg2Of antagonism,documented
R6941 T10338 T10336 arg2Of suppressors,among
R6942 T10338 T10337 arg1Of suppressors,tumor
R6943 T10342 T10339 arg2Of documented,has
R6944 T10342 T10340 arg1Of documented,never
R6945 T10342 T10341 arg2Of documented,been
R6946 T10342 T10343 arg1Of documented,in
R6947 T10345 T10343 arg2Of literature,in
R6948 T10345 T10344 arg1Of literature,the
R6949 T10349 T10346 arg1Of is,However
R6950 T10349 T10347 arg1Of is,","
R6951 T10349 T10350 arg1Of is,not
R6952 T10351 T10349 arg2Of surprising,is
R6953 T10353 T10348 arg1Of find,it
R6954 T10353 T10349 arg1Of find,is
R6955 T10353 T10351 arg1Of find,surprising
R6956 T10353 T10352 arg1Of find,to
R6957 T10358 T10355 arg1Of proteins,many
R6958 T10358 T10356 arg1Of proteins,tumor
R6959 T10358 T10357 arg1Of proteins,suppressor
R6960 T10358 T10359 arg1Of proteins,","
R6961 T10358 T10360 arg1Of proteins,e.g.
R6962 T10358 T10361 arg1Of proteins,","
R6963 T10358 T10375 arg1Of proteins,are
R6964 T10358 T10377 arg2Of proteins,upregulated
R6965 T10362 T10363 arg1Of p53,","
R6966 T10363 T10365 arg1Of ",",","
R6967 T10364 T10363 arg2Of WWOX,","
R6968 T10365 T10367 arg1Of ",",","
R6969 T10366 T10365 arg2Of Smad4,","
R6970 T10367 T10369 arg1Of ",",","
R6971 T10368 T10367 arg2Of PTEN,","
R6972 T10369 T10372 arg1Of ",",and
R6973 T10370 T10369 arg2Of PP2A,","
R6974 T10372 T10361 arg2Of and,","
R6975 T10372 T10371 arg1Of and,","
R6976 T10373 T10372 arg2Of etc.,and
R6977 T10377 T10353 arg2Of upregulated,find
R6978 T10377 T10354 arg1Of upregulated,that
R6979 T10377 T10374 arg1Of upregulated,","
R6980 T10377 T10375 arg2Of upregulated,are
R6981 T10377 T10376 arg1Of upregulated,significantly
R6982 T10377 T10378 arg1Of upregulated,during
R6983 T10377 T10385 arg1Of upregulated,(
R6984 T10381 T10378 arg2Of stage,during
R6985 T10381 T10379 arg1Of stage,the
R6986 T10381 T10380 arg1Of stage,early
R6987 T10381 T10382 arg1Of stage,of
R6988 T10384 T10382 arg2Of progression,of
R6989 T10384 T10383 arg1Of progression,cancer
R6990 T10386 T10385 arg2Of Lai,(
R6991 T10386 T10387 arg1Of Lai,et
R6992 T10386 T10388 arg1Of Lai,al.
R6993 T10386 T10389 arg1Of Lai,","
R6994 T10386 T10391 arg1Of Lai,;
R6995 T10390 T10389 arg2Of 2005,","
R6996 T10392 T10391 arg2Of Chang,;
R6997 T10392 T10393 arg1Of Chang,et
R6998 T10392 T10394 arg1Of Chang,al.
R6999 T10392 T10395 arg1Of Chang,","
R7000 T10396 T10395 arg2Of unpublished,","
R7001 T10397 T10385 arg3Of ),(
R7002 T10399 T10398 arg2Of these,Do
R7003 T10400 T10401 arg1Of proteins,act
R7004 T10400 T10408 arg1Of proteins,lose
R7005 T10401 T10402 arg1Of act,synergistically
R7006 T10401 T10403 arg1Of act,in
R7007 T10401 T10407 arg1Of act,but
R7008 T10404 T10403 arg2Of blocking,in
R7009 T10406 T10404 arg2Of progression,blocking
R7010 T10406 T10405 arg1Of progression,cancer
R7011 T10407 T10398 arg3Of but,Do
R7012 T10408 T10407 arg2Of lose,but
R7013 T10408 T10410 arg1Of lose,eventually
R7014 T10409 T10408 arg2Of control,lose
R7015 T10414 T10413 arg1Of they,do
R7016 T10414 T10415 arg1Of they,counteract
R7017 T10415 T10411 arg1Of counteract,Or
R7018 T10415 T10412 arg1Of counteract,","
R7019 T10415 T10413 arg2Of counteract,do
R7020 T10415 T10419 arg1Of counteract,","
R7021 T10415 T10421 modOf counteract,allowing
R7022 T10418 T10415 arg2Of function,counteract
R7023 T10418 T10416 arg1Of function,each
R7024 T10418 T10417 arg1Of function,other’s
R7025 T10421 T10420 arg1Of allowing,thus
R7026 T10423 T10421 arg2Of growth,allowing
R7027 T10423 T10422 arg1Of growth,cancer
R7028 T10426 T10425 arg1Of WWOX,endogenous
R7029 T10426 T10427 arg1Of WWOX,counteracts
R7030 T10427 T10424 arg1Of counteracts,Whether
R7031 T10427 T10428 arg1Of counteracts,with
R7032 T10427 T10434 arg1Of counteracts,is
R7033 T10427 T10435 arg1Of counteracts,unknown
R7034 T10427 T10437 arg1Of counteracts,remains
R7035 T10427 T10439 arg1Of counteracts,be
R7036 T10427 T10440 arg2Of counteracts,established
R7037 T10430 T10428 arg2Of function,with
R7038 T10430 T10429 arg1Of function,the
R7039 T10430 T10431 arg1Of function,of
R7040 T10433 T10431 arg2Of p53,of
R7041 T10433 T10432 arg1Of p53,endogenous
R7042 T10434 T10436 arg1Of is,and
R7043 T10435 T10434 arg2Of unknown,is
R7044 T10437 T10436 arg2Of remains,and
R7045 T10440 T10437 arg2Of established,remains
R7046 T10440 T10438 arg1Of established,to
R7047 T10440 T10439 arg2Of established,be
R7048 T10441 T10442 arg1Of One,of
R7049 T10441 T10449 arg1Of One,is
R7050 T10445 T10442 arg2Of characteristics,of
R7051 T10445 T10443 arg1Of characteristics,the
R7052 T10445 T10444 arg1Of characteristics,unique
R7053 T10445 T10446 arg1Of characteristics,for
R7054 T10448 T10446 arg2Of gliomas,for
R7055 T10448 T10447 arg1Of gliomas,malignant
R7056 T10452 T10449 arg2Of infiltration,is
R7057 T10452 T10450 arg1Of infiltration,their
R7058 T10452 T10451 arg1Of infiltration,diffuse
R7059 T10452 T10453 arg1Of infiltration,into
R7060 T10456 T10453 arg2Of tissue,into
R7061 T10456 T10454 arg1Of tissue,distant
R7062 T10456 T10455 arg1Of tissue,brain
R7063 T10458 T10457 arg1Of pathways,Signal
R7064 T10458 T10459 arg1Of pathways,","
R7065 T10458 T10460 arg1Of pathways,involving
R7066 T10458 T10472 arg1Of pathways,are
R7067 T10458 T10473 arg2Of pathways,believed
R7068 T10458 T10475 arg1Of pathways,confer
R7069 T10461 T10462 arg1Of PI3K,","
R7070 T10462 T10464 arg1Of ",",","
R7071 T10463 T10462 arg2Of Akt,","
R7072 T10464 T10466 arg1Of ",",","
R7073 T10465 T10464 arg2Of mTOR,","
R7074 T10466 T10469 arg1Of ",",and
R7075 T10467 T10466 arg2Of NF-κB,","
R7076 T10469 T10460 arg2Of and,involving
R7077 T10469 T10468 arg1Of and,","
R7078 T10470 T10469 arg2Of autophagy,and
R7079 T10473 T10471 arg1Of believed,","
R7080 T10473 T10472 arg2Of believed,are
R7081 T10475 T10473 arg3Of confer,believed
R7082 T10475 T10474 arg1Of confer,to
R7083 T10478 T10475 arg2Of cells,confer
R7084 T10478 T10476 arg1Of cells,these
R7085 T10478 T10477 arg1Of cells,migrating
R7086 T10478 T10479 arg1Of cells,resistant
R7087 T10479 T10480 arg1Of resistant,to
R7088 T10482 T10480 arg2Of death,to
R7089 T10482 T10481 arg1Of death,apoptotic
R7090 T10482 T10483 arg1Of death,(
R7091 T10484 T10483 arg2Of Lefranc,(
R7092 T10484 T10485 arg1Of Lefranc,et
R7093 T10484 T10486 arg1Of Lefranc,al.
R7094 T10484 T10487 arg1Of Lefranc,","
R7095 T10488 T10487 arg2Of 2005,","
R7096 T10489 T10483 arg3Of ),(
R7097 T10491 T10490 arg1Of cells,Glioma
R7098 T10491 T10492 arg1Of cells,possess
R7099 T10492 T10494 arg1Of possess,as
R7100 T10493 T10492 arg2Of CD44,possess
R7101 T10496 T10497 arg1Of receptor,for
R7102 T10496 T10517 arg1Of receptor,and
R7103 T10498 T10497 arg2Of interacting,for
R7104 T10498 T10499 arg1Of interacting,with
R7105 T10498 T10503 arg1Of interacting,(
R7106 T10502 T10499 arg2Of hyaluronan,with
R7107 T10502 T10500 arg1Of hyaluronan,brain
R7108 T10502 T10501 arg1Of hyaluronan,matrix
R7109 T10504 T10503 arg2Of Murai,(
R7110 T10504 T10505 arg1Of Murai,et
R7111 T10504 T10506 arg1Of Murai,al.
R7112 T10504 T10507 arg1Of Murai,","
R7113 T10504 T10509 arg1Of Murai,;
R7114 T10508 T10507 arg2Of 2004,","
R7115 T10510 T10509 arg2Of Yoshida,;
R7116 T10510 T10511 arg1Of Yoshida,et
R7117 T10510 T10512 arg1Of Yoshida,al.
R7118 T10510 T10513 arg1Of Yoshida,","
R7119 T10514 T10513 arg2Of 2012,","
R7120 T10515 T10503 arg3Of ),(
R7121 T10517 T10494 arg2Of and,as
R7122 T10517 T10495 arg1Of and,a
R7123 T10517 T10516 arg1Of and,","
R7124 T10519 T10520 arg1Of hyaluronidases,and
R7125 T10520 T10517 arg2Of and,and
R7126 T10520 T10518 arg1Of and,secrete
R7127 T10520 T10522 modOf and,to
R7128 T10521 T10520 arg2Of metalloproteinases,and
R7129 T10523 T10522 arg1Of facilitate,to
R7130 T10523 T10526 arg1Of facilitate,(
R7131 T10525 T10523 arg2Of migration,facilitate
R7132 T10525 T10524 arg1Of migration,their
R7133 T10527 T10526 arg2Of Delpech,(
R7134 T10527 T10528 arg1Of Delpech,et
R7135 T10527 T10529 arg1Of Delpech,al.
R7136 T10527 T10530 arg1Of Delpech,","
R7137 T10527 T10532 arg1Of Delpech,;
R7138 T10527 T10538 arg1Of Delpech,;
R7139 T10531 T10530 arg2Of 2002,","
R7140 T10533 T10532 arg2Of Junker,;
R7141 T10533 T10534 arg1Of Junker,et
R7142 T10533 T10535 arg1Of Junker,al.
R7143 T10533 T10536 arg1Of Junker,","
R7144 T10537 T10536 arg2Of 2003,","
R7145 T10539 T10538 arg2Of Hagemann,;
R7146 T10539 T10540 arg1Of Hagemann,et
R7147 T10539 T10541 arg1Of Hagemann,al.
R7148 T10539 T10542 arg1Of Hagemann,","
R7149 T10543 T10542 arg2Of 2012,","
R7150 T10544 T10526 arg3Of ),(
R7151 T10547 T10548 arg1Of lack,of
R7152 T10547 T10551 arg1Of lack,is
R7153 T10547 T10552 arg2Of lack,expected
R7154 T10547 T10554 arg1Of lack,enhance
R7155 T10550 T10548 arg2Of expression,of
R7156 T10550 T10549 arg1Of expression,WWOX
R7157 T10552 T10545 arg1Of expected,Also
R7158 T10552 T10546 arg1Of expected,","
R7159 T10552 T10551 arg2Of expected,is
R7160 T10554 T10552 arg3Of enhance,expected
R7161 T10554 T10553 arg1Of enhance,to
R7162 T10556 T10554 arg2Of migration,enhance
R7163 T10556 T10555 arg1Of migration,cell
R7164 T10558 T10557 arg2Of example,For
R7165 T10560 T10561 arg1Of loss,of
R7166 T10560 T10563 arg1Of loss,facilitates
R7167 T10562 T10561 arg2Of WWOX,of
R7168 T10563 T10557 arg1Of facilitates,For
R7169 T10563 T10559 arg1Of facilitates,","
R7170 T10563 T10571 arg1Of facilitates,(
R7171 T10564 T10563 arg2Of migration,facilitates
R7172 T10564 T10565 arg1Of migration,of
R7173 T10567 T10566 arg1Of cancer,ovarian
R7174 T10567 T10568 arg1Of cancer,and
R7175 T10568 T10565 arg2Of and,of
R7176 T10570 T10568 arg2Of cells,and
R7177 T10570 T10569 arg1Of cells,osteosarcoma
R7178 T10572 T10571 arg2Of Gourley,(
R7179 T10572 T10573 arg1Of Gourley,et
R7180 T10572 T10574 arg1Of Gourley,al.
R7181 T10572 T10575 arg1Of Gourley,","
R7182 T10572 T10577 arg1Of Gourley,;
R7183 T10576 T10575 arg2Of 2009,","
R7184 T10579 T10577 arg2Of Mare,;
R7185 T10579 T10578 arg1Of Mare,Del
R7186 T10579 T10580 arg1Of Mare,et
R7187 T10579 T10581 arg1Of Mare,al.
R7188 T10579 T10582 arg1Of Mare,","
R7189 T10583 T10582 arg2Of 2011,","
R7190 T10584 T10571 arg3Of ),(
R7191 T10586 T10585 arg1Of expression,Ectopic
R7192 T10586 T10587 arg1Of expression,of
R7193 T10586 T10599 arg1Of expression,suppresses
R7194 T10586 T10606 arg1Of expression,causes
R7195 T10588 T10589 arg1Of TIAF1,(
R7196 T10588 T10594 arg1Of TIAF1,","
R7197 T10592 T10589 arg2Of factor,(
R7198 T10592 T10590 arg1Of factor,TGF-β-induced
R7199 T10592 T10591 arg1Of factor,antiapoptotic
R7200 T10593 T10589 arg3Of ),(
R7201 T10594 T10597 arg1Of ",",and
R7202 T10595 T10594 arg2Of p53,","
R7203 T10597 T10587 arg2Of and,of
R7204 T10597 T10596 arg1Of and,","
R7205 T10598 T10597 arg2Of WWOX,and
R7206 T10599 T10605 arg1Of suppresses,and
R7207 T10601 T10600 arg1Of growth,anchorage-independent
R7208 T10601 T10602 arg1Of growth,and
R7209 T10602 T10599 arg2Of and,suppresses
R7210 T10604 T10602 arg2Of migration,and
R7211 T10604 T10603 arg1Of migration,cell
R7212 T10606 T10605 arg2Of causes,and
R7213 T10607 T10606 arg2Of apoptosis,causes
R7214 T10607 T10608 arg1Of apoptosis,in
R7215 T10610 T10608 arg2Of cells,in
R7216 T10610 T10609 arg1Of cells,cancer
R7217 T10610 T10611 arg1Of cells,(
R7218 T10612 T10611 arg2Of Chang,(
R7219 T10612 T10613 arg1Of Chang,et
R7220 T10612 T10614 arg1Of Chang,al.
R7221 T10612 T10615 arg1Of Chang,","
R7222 T10616 T10615 arg2Of 2012,","
R7223 T10617 T10611 arg3Of ),(
R7224 T10618 T10619 arg1Of We,believe
R7225 T10622 T10621 arg1Of cells,glioma
R7226 T10622 T10623 arg1Of cells,","
R7227 T10622 T10624 arg1Of cells,with
R7228 T10622 T10629 arg1Of cells,migrate
R7229 T10627 T10624 arg2Of properties,with
R7230 T10627 T10625 arg1Of properties,stem
R7231 T10627 T10626 arg1Of properties,cell-like
R7232 T10629 T10619 arg2Of migrate,believe
R7233 T10629 T10620 arg1Of migrate,that
R7234 T10629 T10628 arg1Of migrate,","
R7235 T10629 T10630 arg1Of migrate,individually
R7236 T10629 T10631 arg1Of migrate,rather
R7237 T10631 T10632 arg1Of rather,than
R7238 T10633 T10632 arg2Of collectively,than
R7239 T10635 T10634 arg1Of assumption,This
R7240 T10635 T10636 arg1Of assumption,is
R7241 T10635 T10637 arg2Of assumption,based
R7242 T10637 T10636 arg2Of based,is
R7243 T10637 T10638 arg1Of based,upon
R7244 T10640 T10638 arg2Of observations,upon
R7245 T10640 T10639 arg1Of observations,our
R7246 T10646 T10642 arg1Of cells,mouse
R7247 T10646 T10643 arg1Of cells,Wwox
R7248 T10646 T10644 arg1Of cells,gene
R7249 T10646 T10645 arg1Of cells,knockout
R7250 T10646 T10647 arg1Of cells,(
R7251 T10646 T10653 arg1Of cells,migrate
R7252 T10651 T10647 arg2Of fibroblasts,(
R7253 T10651 T10648 arg1Of fibroblasts,e.g.
R7254 T10651 T10649 arg1Of fibroblasts,","
R7255 T10651 T10650 arg1Of fibroblasts,embryonic
R7256 T10652 T10647 arg3Of ),(
R7257 T10653 T10640 arg2Of migrate,observations
R7258 T10653 T10641 arg1Of migrate,that
R7259 T10653 T10654 arg1Of migrate,individually
R7260 T10653 T10656 arg1Of migrate,aggressively
R7261 T10654 T10655 arg1Of individually,and
R7262 T10656 T10655 arg2Of aggressively,and
R7263 T10658 T10657 arg2Of contrast,In
R7264 T10662 T10660 arg1Of cells,wild
R7265 T10662 T10661 arg1Of cells,type
R7266 T10662 T10663 arg1Of cells,migrate
R7267 T10663 T10657 arg1Of migrate,In
R7268 T10663 T10659 arg1Of migrate,","
R7269 T10663 T10664 arg1Of migrate,collectively
R7270 T10663 T10665 arg1Of migrate,(
R7271 T10666 T10665 arg2Of Chou,(
R7272 T10666 T10667 arg1Of Chou,et
R7273 T10666 T10668 arg1Of Chou,al.
R7274 T10666 T10669 arg1Of Chou,","
R7275 T10670 T10669 arg2Of unpublished,","
R7276 T10671 T10665 arg3Of ),(
R7277 T10674 T10673 arg1Of portion,a
R7278 T10674 T10675 arg1Of portion,of
R7279 T10674 T10677 arg1Of portion,is
R7280 T10674 T10678 arg2Of portion,anchored
R7281 T10676 T10675 arg2Of WWOX,of
R7282 T10678 T10672 arg2Of anchored,While
R7283 T10678 T10677 arg2Of anchored,is
R7284 T10678 T10679 arg1Of anchored,on
R7285 T10682 T10679 arg2Of membrane/cytoskeleton,on
R7286 T10682 T10680 arg1Of membrane/cytoskeleton,the
R7287 T10682 T10681 arg1Of membrane/cytoskeleton,cell
R7288 T10685 T10684 arg1Of cells,WWOX-negative
R7289 T10685 T10686 arg1Of cells,lose
R7290 T10686 T10672 arg1Of lose,While
R7291 T10686 T10683 arg1Of lose,","
R7292 T10686 T10688 arg1Of lose,by
R7293 T10686 T10693 arg1Of lose,and
R7294 T10687 T10686 arg2Of recognition,lose
R7295 T10691 T10688 arg2Of cells,by
R7296 T10691 T10689 arg1Of cells,parental
R7297 T10691 T10690 arg1Of cells,WWOX-positive
R7298 T10693 T10692 arg1Of and,","
R7299 T10694 T10695 arg1Of this,increases
R7300 T10695 T10693 arg2Of increases,and
R7301 T10697 T10695 arg2Of mobility,increases
R7302 T10697 T10696 arg1Of mobility,the
R7303 T10697 T10698 arg1Of mobility,of
R7304 T10697 T10701 modOf mobility,to
R7305 T10700 T10698 arg2Of cells,of
R7306 T10700 T10699 arg1Of cells,WWOX-negative
R7307 T10702 T10701 arg1Of move,to
R7308 T10702 T10703 arg1Of move,away
R7309 T10703 T10704 arg1Of away,from
R7310 T10707 T10704 arg2Of cells,from
R7311 T10707 T10705 arg1Of cells,the
R7312 T10707 T10706 arg1Of cells,WWOX-positive
R7313 T10712 T10710 arg1Of cells,WWOX-negative
R7314 T10712 T10711 arg1Of cells,glioma
R7315 T10712 T10713 arg1Of cells,migrate
R7316 T10712 T10716 arg1Of cells,turn
R7317 T10713 T10714 arg1Of migrate,individually
R7318 T10713 T10715 arg1Of migrate,and
R7319 T10715 T10708 arg1Of and,Conceivably
R7320 T10715 T10709 arg1Of and,","
R7321 T10716 T10715 arg2Of turn,and
R7322 T10716 T10717 arg1Of turn,away
R7323 T10716 T10718 arg1Of turn,from
R7324 T10716 T10722 arg1Of turn,to
R7325 T10721 T10718 arg2Of cells,from
R7326 T10721 T10719 arg1Of cells,WWOX-expressing
R7327 T10721 T10720 arg1Of cells,brain
R7328 T10726 T10722 arg2Of areas,to
R7329 T10726 T10723 arg1Of areas,low
R7330 T10726 T10724 arg1Of areas,WWOX
R7331 T10726 T10725 arg1Of areas,expression
R7332 T10731 T10729 arg1Of behavior,the
R7333 T10731 T10730 arg1Of behavior,migratory
R7334 T10731 T10732 arg1Of behavior,of
R7335 T10731 T10736 arg1Of behavior,may
R7336 T10731 T10737 arg1Of behavior,account
R7337 T10735 T10732 arg2Of cells,of
R7338 T10735 T10733 arg1Of cells,WWOX-negative
R7339 T10735 T10734 arg1Of cells,glioma
R7340 T10737 T10727 arg1Of account,Apparently
R7341 T10737 T10728 arg1Of account,","
R7342 T10737 T10736 arg2Of account,may
R7343 T10737 T10738 arg1Of account,for
R7344 T10741 T10738 arg2Of invasion,for
R7345 T10741 T10739 arg1Of invasion,the
R7346 T10741 T10740 arg1Of invasion,diffuse
R7347 T10741 T10742 arg1Of invasion,into
R7348 T10745 T10742 arg2Of tissue,into
R7349 T10745 T10743 arg1Of tissue,distant
R7350 T10745 T10744 arg1Of tissue,brain
R7351 T10745 T10746 arg1Of tissue,(
R7352 T10747 T10746 arg2Of Chou,(
R7353 T10747 T10748 arg1Of Chou,et
R7354 T10747 T10749 arg1Of Chou,al.
R7355 T10747 T10750 arg1Of Chou,","
R7356 T10751 T10750 arg2Of unpublished,","
R7357 T10752 T10746 arg3Of ),(
R7358 T10754 T10753 arg1Of alterations,Metabolic
R7359 T10754 T10755 arg1Of alterations,have
R7360 T10754 T10756 arg1Of alterations,been
R7361 T10754 T10757 arg2Of alterations,shown
R7362 T10757 T10755 arg2Of shown,have
R7363 T10757 T10756 arg2Of shown,been
R7364 T10757 T10758 arg1Of shown,in
R7365 T10761 T10758 arg2Of mice,in
R7366 T10761 T10759 arg1Of mice,Wwox
R7367 T10761 T10760 arg1Of mice,knockout
R7368 T10761 T10762 arg1Of mice,","
R7369 T10761 T10763 arg1Of mice,including
R7370 T10765 T10764 arg1Of lethality,postnatal
R7371 T10765 T10766 arg1Of lethality,","
R7372 T10766 T10770 arg1Of ",",","
R7373 T10769 T10766 arg2Of defects,","
R7374 T10769 T10767 arg1Of defects,bone
R7375 T10769 T10768 arg1Of defects,metabolism
R7376 T10770 T10772 arg1Of ",",","
R7377 T10771 T10770 arg2Of ataxia,","
R7378 T10772 T10775 arg1Of ",",and
R7379 T10773 T10772 arg2Of steroidogenesis,","
R7380 T10775 T10763 arg2Of and,including
R7381 T10775 T10774 arg1Of and,","
R7382 T10775 T10779 arg1Of and,(
R7383 T10776 T10775 arg2Of generation,and
R7384 T10776 T10777 arg1Of generation,of
R7385 T10778 T10777 arg2Of osteosarcomas,of
R7386 T10781 T10779 arg2Of Mare,(
R7387 T10781 T10780 arg1Of Mare,Del
R7388 T10781 T10782 arg1Of Mare,et
R7389 T10781 T10783 arg1Of Mare,al.
R7390 T10781 T10784 arg1Of Mare,","
R7391 T10781 T10786 arg1Of Mare,;
R7392 T10785 T10784 arg2Of 2011,","
R7393 T10787 T10786 arg2Of Salah,;
R7394 T10787 T10788 arg1Of Salah,et
R7395 T10787 T10789 arg1Of Salah,al.
R7396 T10787 T10790 arg1Of Salah,","
R7397 T10791 T10790 arg2Of 2012,","
R7398 T10792 T10779 arg3Of ),(
R7399 T10796 T10793 arg2Of model,In
R7400 T10796 T10794 arg1Of model,a
R7401 T10796 T10795 arg1Of model,Drosophila
R7402 T10798 T10799 arg1Of Wwox,is
R7403 T10798 T10800 arg2Of Wwox,shown
R7404 T10798 T10802 arg1Of Wwox,participate
R7405 T10800 T10793 arg1Of shown,In
R7406 T10800 T10797 arg1Of shown,","
R7407 T10800 T10799 arg2Of shown,is
R7408 T10802 T10800 arg3Of participate,shown
R7409 T10802 T10801 arg1Of participate,to
R7410 T10802 T10803 arg1Of participate,in
R7411 T10804 T10803 arg2Of pathways,in
R7412 T10804 T10805 arg1Of pathways,involving
R7413 T10807 T10806 arg1Of metabolism,aerobic
R7414 T10807 T10808 arg1Of metabolism,and
R7415 T10808 T10805 arg2Of and,involving
R7416 T10808 T10811 arg1Of and,for
R7417 T10810 T10808 arg2Of stress,and
R7418 T10810 T10809 arg1Of stress,oxidative
R7419 T10812 T10811 arg2Of generation,for
R7420 T10812 T10813 arg1Of generation,of
R7421 T10814 T10813 arg2Of ROS,of
R7422 T10814 T10815 arg1Of ROS,(
R7423 T10816 T10815 arg2Of O’Keefe,(
R7424 T10816 T10817 arg1Of O’Keefe,et
R7425 T10816 T10818 arg1Of O’Keefe,al.
R7426 T10816 T10819 arg1Of O’Keefe,","
R7427 T10820 T10819 arg2Of 2011,","
R7428 T10821 T10815 arg3Of ),(
R7429 T10824 T10822 arg2Of stress,Under
R7430 T10824 T10823 arg1Of stress,UV
R7431 T10827 T10830 modOf Wwox,induces
R7432 T10827 T10833 arg1Of Wwox,in
R7433 T10829 T10828 arg1Of expression,gene
R7434 T10829 T10830 arg1Of expression,induces
R7435 T10832 T10830 arg2Of production,induces
R7436 T10832 T10831 arg1Of production,ROS
R7437 T10834 T10826 arg1Of Drosophila.,functional
R7438 T10834 T10827 arg1Of Drosophila.,Wwox
R7439 T10834 T10837 modOf Drosophila.,are
R7440 T10836 T10835 arg1Of cells,Cancer
R7441 T10836 T10837 arg1Of cells,are
R7442 T10836 T10838 arg2Of cells,known
R7443 T10836 T10841 arg1Of cells,utilize
R7444 T10838 T10837 arg2Of known,are
R7445 T10841 T10838 arg3Of utilize,known
R7446 T10841 T10839 arg1Of utilize,to
R7447 T10841 T10840 arg1Of utilize,overly
R7448 T10842 T10841 arg2Of glycolysis,utilize
R7449 T10845 T10834 arg1Of advantage,Drosophila.
R7450 T10845 T10843 arg1Of advantage,for
R7451 T10845 T10844 arg1Of advantage,growth
R7452 T10845 T10846 arg1Of advantage,–
R7453 T10846 T10822 arg1Of –,Under
R7454 T10846 T10825 arg1Of –,","
R7455 T10849 T10846 arg2Of Warburg,–
R7456 T10849 T10847 arg1Of Warburg,the
R7457 T10849 T10848 arg1Of Warburg,so-called
R7458 T10849 T10850 arg1Of Warburg,(
R7459 T10851 T10850 arg2Of Moncada,(
R7460 T10851 T10852 arg1Of Moncada,et
R7461 T10851 T10853 arg1Of Moncada,al.
R7462 T10851 T10854 arg1Of Moncada,","
R7463 T10855 T10854 arg2Of 2012,","
R7464 T10856 T10850 arg3Of ),(
R7465 T10859 T10860 arg1Of WWOX,is
R7466 T10859 T10861 arg1Of WWOX,likely
R7467 T10859 T10863 arg1Of WWOX,override
R7468 T10859 T10870 arg1Of WWOX,exerts
R7469 T10860 T10869 arg1Of is,and
R7470 T10861 T10860 arg2Of likely,is
R7471 T10863 T10861 arg2Of override,likely
R7472 T10863 T10862 arg1Of override,to
R7473 T10865 T10863 arg2Of consumption,override
R7474 T10865 T10864 arg1Of consumption,glucose
R7475 T10865 T10866 arg1Of consumption,in
R7476 T10868 T10866 arg2Of cells,in
R7477 T10868 T10867 arg1Of cells,cancer
R7478 T10869 T10857 arg1Of and,Conceivably
R7479 T10869 T10858 arg1Of and,","
R7480 T10870 T10869 arg2Of exerts,and
R7481 T10871 T10870 arg2Of generation,exerts
R7482 T10871 T10872 arg1Of generation,of
R7483 T10871 T10874 modOf generation,to
R7484 T10873 T10872 arg2Of ROS,of
R7485 T10875 T10874 arg1Of curb,to
R7486 T10879 T10880 arg1Of growth,and
R7487 T10880 T10875 arg2Of and,curb
R7488 T10880 T10876 arg1Of and,the
R7489 T10880 T10877 arg1Of and,cancer
R7490 T10880 T10878 arg1Of and,cell
R7491 T10881 T10880 arg2Of invasion,and
R7492 T10883 T10882 arg2Of summary,In
R7493 T10888 T10885 arg2Of article,in
R7494 T10888 T10886 arg1Of article,this
R7495 T10888 T10887 arg1Of article,perspective
R7496 T10889 T10890 arg1Of we,have
R7497 T10889 T10891 arg1Of we,discussed
R7498 T10891 T10882 arg1Of discussed,In
R7499 T10891 T10884 arg1Of discussed,","
R7500 T10891 T10885 arg1Of discussed,in
R7501 T10891 T10890 arg2Of discussed,have
R7502 T10894 T10891 arg2Of role,discussed
R7503 T10894 T10892 arg1Of role,the
R7504 T10894 T10893 arg1Of role,potential
R7505 T10894 T10895 arg1Of role,of
R7506 T10894 T10901 arg1Of role,in
R7507 T10898 T10899 arg1Of p53,and
R7508 T10899 T10895 arg2Of and,of
R7509 T10899 T10896 arg1Of and,tumor
R7510 T10899 T10897 arg1Of and,suppressors
R7511 T10900 T10899 arg2Of WWOX,and
R7512 T10902 T10901 arg2Of regulating,in
R7513 T10904 T10902 arg2Of sensitivity,regulating
R7514 T10904 T10903 arg1Of sensitivity,TMZ
R7515 T10904 T10905 arg1Of sensitivity,in
R7516 T10907 T10905 arg2Of cells,in
R7517 T10907 T10906 arg1Of cells,GBM
R7518 T10908 T10909 arg1Of We,have
R7519 T10908 T10910 arg1Of We,shown
R7524 T10912 T10911 arg1Of role,the
R7525 T10912 T10913 arg1Of role,of
R7526 T10912 T10915 arg1Of role,in
R7527 T10914 T10913 arg2Of WWOX,of
R7528 T10916 T10915 arg2Of controlling,in
R7529 T10918 T10917 arg1Of migration,cell
R7530 T10918 T10919 arg1Of migration,and
R7531 T10919 T10916 arg2Of and,controlling
R7532 T10921 T10919 arg2Of alterations,and
R7533 T10921 T10920 arg1Of alterations,metabolic
R7534 T10923 T10922 arg1Of and,","
R7535 T10924 T10923 arg2Of discussed,and
R7536 T10926 T10924 arg2Of effects,discussed
R7537 T10926 T10925 arg1Of effects,the
R7538 T10926 T10927 arg1Of effects,of
R7539 T10929 T10928 arg1Of deficiency,WWOX
R7540 T10929 T10930 arg1Of deficiency,and
R7541 T10930 T10927 arg2Of and,of
R7542 T10930 T10933 arg1Of and,in
R7543 T10932 T10930 arg2Of resistance,and
R7544 T10932 T10931 arg1Of resistance,TMZ
R7545 T10935 T10933 arg2Of cells,in
R7546 T10935 T10934 arg1Of cells,cancer
R8607 T12473 T12472 arg1Of Chiang,Ming-Fu
R8608 T12473 T12474 arg1Of Chiang,and
R8609 T12474 T12477 arg1Of and,wrote
R8610 T12476 T12474 arg2Of Sze,and
R8611 T12476 T12475 arg1Of Sze,Chun-I
R8612 T12477 T12483 arg1Of wrote,;
R8613 T12479 T12477 arg2Of sections,wrote
R8614 T12479 T12478 arg1Of sections,the
R8615 T12479 T12480 arg1Of sections,dealing
R8616 T12480 T12481 arg1Of dealing,with
R8617 T12482 T12481 arg2Of TMZ,with
R8618 T12485 T12484 arg1Of Chou,Pei-Yi
R8619 T12485 T12486 arg1Of Chou,wrote
R8620 T12486 T12483 arg2Of wrote,;
R8621 T12486 T12497 arg1Of wrote,;
R8622 T12489 T12486 arg2Of sections,wrote
R8623 T12489 T12487 arg1Of sections,the
R8624 T12489 T12488 arg1Of sections,review
R8625 T12489 T12490 arg1Of sections,for
R8626 T12491 T12492 arg1Of p53,and
R8627 T12492 T12494 arg1Of and,and
R8628 T12493 T12492 arg2Of WWOX,and
R8629 T12494 T12490 arg2Of and,for
R8630 T12496 T12494 arg2Of graphs,and
R8631 T12496 T12495 arg2Of graphs,designed
R8632 T12499 T12498 arg1Of Wang,Wan-Jen
R8633 T12499 T12500 arg1Of Wang,managed
R8634 T12500 T12497 arg2Of managed,;
R8635 T12500 T12502 arg1Of managed,;
R8636 T12501 T12500 arg2Of citations,managed
R8637 T12504 T12503 arg1Of Chang,Nan-Shan
R8638 T12504 T12505 arg1Of Chang,conceived
R8639 T12504 T12508 arg1Of Chang,wrote
R8640 T12504 T12511 arg1Of Chang,revised
R8641 T12504 T12516 arg2Of Chang,discussed
R8642 T12505 T12507 arg1Of conceived,","
R8643 T12506 T12505 arg2Of ideas,conceived
R8644 T12507 T12509 arg1Of ",",and
R8645 T12508 T12507 arg2Of wrote,","
R8646 T12509 T12515 arg1Of and,and
R8647 T12511 T12509 arg2Of revised,and
R8648 T12511 T12510 arg1Of revised,thoroughly
R8649 T12513 T12511 arg2Of manuscript,revised
R8650 T12513 T12512 arg1Of manuscript,the
R8651 T12515 T12502 arg2Of and,;
R8652 T12515 T12514 arg1Of and,","
R8653 T12516 T12515 arg2Of discussed,and
R8654 T12516 T12517 arg1Of discussed,with
R8655 T12518 T12517 arg2Of coauthors,with
R8704 T12592 T12591 arg1Of authors,The
R8705 T12592 T12593 arg1Of authors,declare
R8706 T12596 T12595 arg1Of research,the
R8707 T12596 T12597 arg1Of research,was
R8708 T12596 T12598 arg2Of research,conducted
R8709 T12598 T12593 arg2Of conducted,declare
R8710 T12598 T12594 arg1Of conducted,that
R8711 T12598 T12597 arg2Of conducted,was
R8712 T12598 T12599 arg1Of conducted,in
R8713 T12599 T12600 arg1Of in,the
R8714 T12599 T12602 arg1Of in,of
R8715 T12601 T12599 arg2Of absence,in
R8716 T12604 T12605 arg1Of commercial,or
R8717 T12606 T12605 arg2Of financial,or
R8718 T12607 T12599 arg3Of relationships,in
R8719 T12607 T12603 arg1Of relationships,any
R8720 T12607 T12604 arg1Of relationships,commercial
R8721 T12607 T12606 arg1Of relationships,financial
R8722 T12607 T12608 arg1Of relationships,that
R8723 T12607 T12609 arg1Of relationships,could
R8724 T12607 T12610 arg1Of relationships,be
R8725 T12607 T12611 arg2Of relationships,construed
R8726 T12611 T12609 arg2Of construed,could
R8727 T12611 T12610 arg2Of construed,be
R8728 T12611 T12612 arg1Of construed,as
R8729 T12615 T12612 arg2Of conflict,as
R8730 T12615 T12613 arg1Of conflict,a
R8731 T12615 T12614 arg1Of conflict,potential
R8732 T12615 T12616 arg1Of conflict,of
R8733 T12617 T12616 arg2Of interest,of
R8982 T13044 T13043 arg1Of diagrams,Schematic
R8983 T13044 T13045 arg1Of diagrams,of
R8984 T13044 T13048 arg1Of diagrams,and
R8985 T13047 T13045 arg2Of structure,of
R8986 T13047 T13046 arg1Of structure,WWOX
R8987 T13050 T13048 arg2Of role,and
R8988 T13050 T13049 arg1Of role,its
R8989 T13050 T13051 arg1Of role,in
R8990 T13052 T13051 arg2Of signaling,in
R8991 T13053 T13054 arg1Of WWOX,contains
R8992 T13058 T13055 arg1Of domains,two
R8993 T13058 T13056 arg1Of domains,N-terminal
R8994 T13058 T13057 arg1Of domains,WW
R8995 T13058 T13059 arg1Of domains,","
R8996 T13058 T13070 arg1Of domains,and
R8997 T13066 T13065 arg2Of SDR,(
R8998 T13067 T13065 arg3Of ),(
R8999 T13068 T13059 arg2Of domain,","
R9000 T13068 T13060 arg1Of domain,a
R9001 T13068 T13061 arg1Of domain,C-terminal
R9002 T13068 T13062 arg1Of domain,short-chain
R9003 T13068 T13063 arg1Of domain,alcohol
R9004 T13068 T13064 arg1Of domain,dehydrogenase/reductase
R9005 T13068 T13065 arg1Of domain,(
R9006 T13070 T13054 arg2Of and,contains
R9007 T13070 T13069 arg1Of and,","
R9008 T13073 T13070 arg2Of region,and
R9009 T13073 T13071 arg1Of region,a
R9010 T13073 T13072 arg1Of region,D3
R9011 T13077 T13074 arg1Of signal,A
R9012 T13077 T13075 arg1Of signal,nuclear
R9013 T13077 T13076 arg1Of signal,localization
R9014 T13077 T13078 arg1Of signal,(
R9015 T13077 T13081 arg1Of signal,is
R9016 T13077 T13083 arg1Of signal,between
R9017 T13079 T13078 arg2Of NLS,(
R9018 T13080 T13078 arg3Of ),(
R9019 T13081 T13087 arg1Of is,(
R9020 T13083 T13081 arg2Of between,is
R9021 T13083 T13082 arg1Of between,in
R9022 T13086 T13083 arg2Of domains,between
R9023 T13086 T13084 arg1Of domains,the
R9024 T13086 T13085 arg1Of domains,WW
R9025 T13088 T13089 arg1Of Chang,et
R9026 T13088 T13090 arg1Of Chang,al.
R9027 T13088 T13091 arg1Of Chang,","
R9028 T13091 T13093 arg1Of ",",","
R9029 T13092 T13091 arg2Of 2003,","
R9030 T13093 T13095 arg1Of ",",;
R9031 T13094 T13093 arg2Of 2007,","
R9032 T13095 T13102 arg1Of ;,;
R9033 T13097 T13096 arg1Of Mare,Del
R9034 T13097 T13098 arg1Of Mare,et
R9035 T13097 T13099 arg1Of Mare,al.
R9036 T13097 T13100 arg1Of Mare,","
R9037 T13100 T13095 arg2Of ",",;
R9038 T13101 T13100 arg2Of 2011,","
R9039 T13102 T13087 arg2Of ;,(
R9040 T13102 T13114 arg1Of ;,;
R9041 T13103 T13104 arg1Of Salah,et
R9042 T13103 T13105 arg1Of Salah,al.
R9043 T13103 T13106 arg1Of Salah,","
R9044 T13106 T13108 arg1Of ",",;
R9045 T13107 T13106 arg2Of 2012,","
R9046 T13108 T13112 arg1Of ;,","
R9047 T13109 T13108 arg2Of Su,;
R9048 T13109 T13110 arg1Of Su,et
R9049 T13109 T13111 arg1Of Su,al.
R9050 T13112 T13102 arg2Of ",",;
R9051 T13113 T13112 arg2Of 2012,","
R9052 T13115 T13114 arg2Of reviews,;
R9053 T13116 T13087 arg3Of ),(
R9054 T13119 T13117 arg1Of domain,The
R9055 T13119 T13118 arg1Of domain,SDR
R9056 T13119 T13120 arg1Of domain,possesses
R9057 T13123 T13120 arg2Of region,possesses
R9058 T13123 T13121 arg1Of region,a
R9059 T13123 T13122 arg1Of region,mitochondria-binding
R9060 T13124 T13125 arg1Of There,are
R9061 T13130 T13125 arg2Of sites,are
R9062 T13130 T13126 arg1Of sites,two
R9063 T13130 T13127 arg2Of sites,conserved
R9064 T13130 T13128 arg1Of sites,tyrosine
R9065 T13130 T13129 arg1Of sites,phosphorylation
R9066 T13130 T13131 arg1Of sites,","
R9067 T13132 T13133 arg1Of Tyr33,and
R9068 T13133 T13131 arg2Of and,","
R9069 T13134 T13133 arg2Of Tyr287,and
R9070 T13137 T13135 arg1Of sites,Other
R9071 T13137 T13136 arg1Of sites,phosphorylation
R9072 T13137 T13138 arg2Of sites,predicted
R9073 T13137 T13143 arg1Of sites,are
R9074 T13142 T13138 arg1Of Server,predicted
R9075 T13142 T13139 arg2Of Server,by
R9076 T13142 T13140 arg1Of Server,NetPhos
R9077 T13142 T13141 arg1Of Server,2.0
R9078 T13143 T13156 arg1Of are,","
R9079 T13143 T13157 arg1Of are,respectively
R9080 T13144 T13145 arg1Of Tyr6,","
R9081 T13145 T13147 arg1Of ",",","
R9082 T13146 T13145 arg2Of Thr12,","
R9083 T13147 T13149 arg1Of ",",","
R9084 T13148 T13147 arg2Of Ser14,","
R9085 T13149 T13151 arg1Of ",",","
R9086 T13150 T13149 arg2Of Tyr61,","
R9087 T13151 T13154 arg1Of ",",and
R9088 T13152 T13151 arg2Of Tyr293,","
R9089 T13154 T13143 arg2Of and,are
R9090 T13154 T13153 arg1Of and,","
R9091 T13155 T13154 arg2Of Thr3B3,and
R9092 T13160 T13158 arg2Of stimulation,Upon
R9093 T13160 T13159 arg1Of stimulation,stress
R9094 T13162 T13163 arg1Of WWOX,is
R9095 T13162 T13164 arg2Of WWOX,phosphorylated
R9096 T13162 T13168 arg1Of WWOX,binds
R9097 T13164 T13163 arg2Of phosphorylated,is
R9098 T13164 T13165 arg1Of phosphorylated,in
R9099 T13164 T13167 arg1Of phosphorylated,and
R9100 T13166 T13165 arg2Of Tyr33,in
R9101 T13167 T13158 arg1Of and,Upon
R9102 T13167 T13161 arg1Of and,","
R9103 T13168 T13167 arg2Of binds,and
R9104 T13169 T13168 arg2Of p53,binds
R9105 T13172 T13170 arg1Of complex,The
R9106 T13172 T13171 arg1Of complex,WWOX/p53
R9107 T13172 T13174 arg1Of complex,translocates
R9108 T13174 T13173 arg1Of translocates,then
R9109 T13174 T13175 arg1Of translocates,to
R9110 T13176 T13177 arg1Of mitochondria,or
R9111 T13177 T13175 arg2Of or,to
R9112 T13177 T13179 modOf or,to
R9113 T13178 T13177 arg2Of nucleus,or
R9114 T13180 T13179 arg1Of induce,to
R9115 T13181 T13180 arg2Of apoptosis,induce
R9116 T13182 T13184 arg1Of WWOX,binds
R9117 T13184 T13183 arg1Of binds,also
R9118 T13184 T13205 arg1Of binds,and
R9119 T13188 T13184 arg2Of factors,binds
R9120 T13188 T13185 arg1Of factors,PPxY
R9121 T13188 T13186 arg1Of factors,motif-containing
R9122 T13188 T13187 arg1Of factors,transcription
R9123 T13188 T13189 arg1Of factors,","
R9124 T13188 T13191 arg1Of factors,as
R9125 T13191 T13190 arg1Of as,such
R9126 T13192 T13193 arg1Of RUNX2,","
R9127 T13193 T13196 arg1Of ",",and
R9128 T13194 T13193 arg2Of c-Jun,","
R9129 T13196 T13191 arg2Of and,as
R9130 T13196 T13195 arg1Of and,","
R9131 T13196 T13198 arg1Of and,","
R9132 T13196 T13199 arg1Of and,via
R9133 T13197 T13196 arg2Of ERBB4,and
R9134 T13203 T13199 arg2Of domain,via
R9135 T13203 T13200 arg1Of domain,its
R9136 T13203 T13201 arg1Of domain,first
R9137 T13203 T13202 arg1Of domain,WW
R9138 T13205 T13204 arg1Of and,","
R9139 T13207 T13206 arg1Of binding,the
R9140 T13207 T13208 arg1Of binding,blocks
R9141 T13207 T13215 arg1Of binding,retaining
R9142 T13208 T13205 arg2Of blocks,and
R9143 T13208 T13214 arg1Of blocks,by
R9144 T13210 T13208 arg2Of activity,blocks
R9145 T13210 T13209 arg1Of activity,the
R9146 T13210 T13211 arg1Of activity,of
R9147 T13213 T13211 arg2Of proteins,of
R9148 T13213 T13212 arg1Of proteins,these
R9149 T13215 T13214 arg2Of retaining,by
R9150 T13215 T13217 arg1Of retaining,in
R9151 T13216 T13215 arg2Of them,retaining
R9152 T13219 T13217 arg2Of cytoplasm,in
R9153 T13219 T13218 arg1Of cytoplasm,the
R9154 T13220 T13221 arg1Of WWOX,binds
R9155 T13221 T13223 arg1Of binds,via
R9156 T13222 T13221 arg2Of Tau,binds
R9157 T13226 T13223 arg2Of domain,via
R9158 T13226 T13224 arg1Of domain,its
R9159 T13226 T13225 arg1Of domain,SDR
R9160 T13227 T13228 arg1Of WWOX,participates
R9161 T13227 T13235 arg1Of WWOX,binding
R9162 T13227 T13238 arg1Of WWOX,inhibiting
R9163 T13228 T13229 arg1Of participates,in
R9164 T13228 T13234 arg1Of participates,by
R9165 T13233 T13229 arg2Of pathway,in
R9166 T13233 T13230 arg1Of pathway,the
R9167 T13233 T13231 arg1Of pathway,Wnt/β-catenin
R9168 T13233 T13232 arg1Of pathway,signal
R9169 T13235 T13237 arg1Of binding,and
R9170 T13236 T13235 arg2Of Dvl,binding
R9171 T13237 T13234 arg2Of and,by
R9172 T13238 T13237 arg2Of inhibiting,and
R9173 T13241 T13238 arg2Of import,inhibiting
R9174 T13241 T13239 arg1Of import,its
R9175 T13241 T13240 arg1Of import,nuclear
R9176 T13243 T13242 arg1Of ester,Phorbol
R9177 T13243 T13244 arg1Of ester,stimulates
R9178 T13244 T13255 arg1Of stimulates,and
R9179 T13246 T13244 arg2Of dissociation,stimulates
R9180 T13246 T13245 arg1Of dissociation,the
R9181 T13246 T13247 arg1Of dissociation,of
R9182 T13249 T13247 arg2Of complex,of
R9183 T13249 T13248 arg1Of complex,MEK/WWOX
R9184 T13249 T13250 arg1Of complex,in
R9185 T13253 T13250 arg2Of cell,in
R9186 T13253 T13251 arg1Of cell,Jurkat
R9187 T13253 T13252 arg1Of cell,T
R9188 T13255 T13254 arg1Of and,","
R9189 T13258 T13256 arg1Of WWOX,the
R9190 T13258 T13257 arg2Of WWOX,released
R9191 T13258 T13259 arg1Of WWOX,translocates
R9192 T13259 T13255 arg2Of translocates,and
R9193 T13259 T13260 arg1Of translocates,to
R9194 T13262 T13260 arg2Of mitochondria,to
R9195 T13262 T13261 arg1Of mitochondria,the
R9196 T13262 T13263 arg1Of mitochondria,for
R9197 T13264 T13263 arg2Of causing,for
R9198 T13266 T13264 arg2Of death,causing
R9199 T13266 T13265 arg1Of death,cell
R9200 T13267 T13268 arg1Of WWOX,is
R9201 T13267 T13269 arg2Of WWOX,recruited
R9202 T13269 T13268 arg2Of recruited,is
R9203 T13269 T13270 arg1Of recruited,to
R9204 T13269 T13274 arg1Of recruited,by
R9205 T13269 T13278 arg1Of recruited,and
R9206 T13273 T13270 arg2Of area,to
R9207 T13273 T13271 arg1Of area,the
R9208 T13273 T13272 arg1Of area,membrane
R9209 T13275 T13274 arg2Of association,by
R9210 T13275 T13276 arg1Of association,with
R9211 T13277 T13276 arg2Of Hyal-2,with
R9212 T13280 T13279 arg1Of Hyal-2,phospho-Ezrin.
R9213 T13280 T13281 arg1Of Hyal-2,is
R9214 T13281 T13278 arg2Of is,and
R9215 T13284 T13281 arg2Of receptor,is
R9216 T13284 T13282 arg1Of receptor,an
R9217 T13284 T13283 arg1Of receptor,alternative
R9218 T13284 T13285 arg1Of receptor,for
R9219 T13286 T13285 arg2Of TGF-β1,for
R9220 T13288 T13287 arg2Of response,In
R9221 T13288 T13289 arg1Of response,to
R9222 T13290 T13289 arg2Of TGF-β1,to
R9223 T13292 T13293 arg1Of WWOX,binds
R9224 T13292 T13296 arg1Of WWOX,forms
R9225 T13293 T13295 arg1Of binds,and
R9226 T13294 T13293 arg2Of Hyal-2,binds
R9227 T13295 T13287 arg1Of and,In
R9228 T13295 T13291 arg1Of and,","
R9229 T13295 T13299 arg1Of and,","
R9230 T13295 T13300 modOf and,followed
R9231 T13296 T13295 arg2Of forms,and
R9232 T13298 T13296 arg2Of complex,forms
R9233 T13298 T13297 arg1Of complex,a
R9234 T13300 T13301 arg1Of followed,by
R9235 T13302 T13303 arg1Of relocating,to
R9236 T13302 T13306 arg1Of relocating,and
R9237 T13305 T13303 arg2Of nucleus,to
R9238 T13305 T13304 arg1Of nucleus,the
R9239 T13306 T13301 arg2Of and,by
R9240 T13307 T13306 arg2Of enhancing,and
R9241 T13311 T13307 arg2Of activity,enhancing
R9242 T13311 T13308 arg1Of activity,the
R9243 T13311 T13309 arg1Of activity,SMAD-driven
R9244 T13311 T13310 arg1Of activity,promoter
R9245 T13312 T13313 arg1Of Ack1,","
R9246 T13312 T13318 arg1Of Ack1,;
R9247 T13316 T13313 arg2Of kinase,","
R9248 T13316 T13314 arg2Of kinase,activated
R9249 T13316 T13315 arg1Of kinase,Cdc42-associated
R9250 T13316 T13317 arg1Of kinase,1
R9251 T13319 T13318 arg2Of Hyal-2,;
R9252 T13319 T13320 arg1Of Hyal-2,","
R9253 T13319 T13323 arg1Of Hyal-2,;
R9254 T13321 T13320 arg2Of hyaluronoglucosaminidase,","
R9255 T13321 T13322 arg1Of hyaluronoglucosaminidase,2
R9256 T13324 T13323 arg2Of CKI,;
R9257 T13324 T13325 arg1Of CKI,","
R9258 T13324 T13328 arg1Of CKI,;
R9259 T13327 T13325 arg2Of kinase,","
R9260 T13327 T13326 arg1Of kinase,casein
R9261 T13329 T13328 arg2Of GSK,;
R9262 T13329 T13330 arg1Of GSK,","
R9263 T13329 T13334 arg1Of GSK,;
R9264 T13333 T13330 arg2Of kinase,","
R9265 T13333 T13331 arg1Of kinase,glycogen
R9266 T13333 T13332 arg1Of kinase,synthase
R9267 T13335 T13334 arg2Of PKA,;
R9268 T13335 T13336 arg1Of PKA,","
R9269 T13339 T13336 arg2Of A,","
R9270 T13339 T13337 arg1Of A,protein
R9271 T13339 T13338 arg1Of A,kinase
R9708 T14173 T14174 arg1Of p53,and
R9709 T14174 T14176 arg1Of and,in
R9710 T14174 T14185 arg1Of and,possesses
R9711 T14175 T14174 arg2Of WWOX,and
R9712 T14181 T14180 arg2Of A,(
R9713 T14182 T14180 arg3Of ),(
R9714 T14184 T14176 arg2Of p53,in
R9715 T14184 T14177 arg1Of p53,GBM
R9716 T14184 T14178 arg1Of p53,cell
R9717 T14184 T14179 arg1Of p53,apoptosis.
R9718 T14184 T14180 arg1Of p53,(
R9719 T14184 T14183 arg1Of p53,Full-length
R9720 T14190 T14186 arg1Of domains,two
R9721 T14190 T14187 arg1Of domains,N-terminal
R9722 T14190 T14188 arg1Of domains,transactivation
R9723 T14190 T14189 arg1Of domains,acidic
R9724 T14190 T14191 arg1Of domains,","
R9725 T14190 T14195 arg1Of domains,","
R9726 T14190 T14201 arg1Of domains,and
R9727 T14194 T14191 arg2Of domain,","
R9728 T14194 T14192 arg1Of domain,a
R9729 T14194 T14193 arg1Of domain,proline-rich
R9730 T14199 T14195 arg2Of region,","
R9731 T14199 T14196 arg1Of region,a
R9732 T14199 T14197 arg1Of region,central
R9733 T14199 T14198 arg1Of region,DNA-binding
R9734 T14201 T14200 arg1Of and,","
R9735 T14201 T14216 arg1Of and,and
R9736 T14204 T14201 arg2Of domain,and
R9737 T14204 T14202 arg1Of domain,a
R9738 T14204 T14203 arg1Of domain,C-terminal
R9739 T14204 T14205 arg1Of domain,","
R9740 T14204 T14206 arg1Of domain,containing
R9741 T14204 T14211 arg1Of domain,","
R9742 T14210 T14206 arg2Of signal,containing
R9743 T14210 T14207 arg1Of signal,a
R9744 T14210 T14208 arg1Of signal,nuclear
R9745 T14210 T14209 arg1Of signal,localization
R9746 T14214 T14211 arg2Of domain,","
R9747 T14214 T14212 arg1Of domain,an
R9748 T14214 T14213 arg1Of domain,oligomerization
R9749 T14216 T14185 arg2Of and,possesses
R9750 T14216 T14215 arg1Of and,","
R9751 T14219 T14216 arg2Of region,and
R9752 T14219 T14217 arg1Of region,a
R9753 T14219 T14218 arg1Of region,basic
R9754 T14222 T14220 arg1Of mutants,N-terminal
R9755 T14222 T14221 arg1Of mutants,deletion
R9756 T14222 T14223 arg1Of mutants,of
R9757 T14222 T14225 arg1Of mutants,are
R9758 T14224 T14223 arg2Of p53,of
R9759 T14225 T14226 arg1Of are,also
R9760 T14227 T14225 arg2Of shown.,are
R9761 T14227 T14228 arg1Of shown.,(
R9762 T14227 T14234 modOf shown.,are
R9763 T14229 T14228 arg2Of B,(
R9764 T14230 T14228 arg3Of ),(
R9765 T14233 T14231 arg1Of scenarios,Three
R9766 T14233 T14232 arg1Of scenarios,likely
R9767 T14233 T14234 arg1Of scenarios,are
R9768 T14233 T14235 arg2Of scenarios,proposed
R9769 T14235 T14234 arg2Of proposed,are
R9770 T14235 T14236 arg1Of proposed,for
R9771 T14237 T14238 arg1Of WWOX,and
R9772 T14238 T14236 arg2Of and,for
R9773 T14238 T14240 modOf and,to
R9774 T14239 T14238 arg2Of p53,and
R9775 T14241 T14240 arg1Of regulate,to
R9776 T14244 T14241 arg2Of death,regulate
R9777 T14244 T14242 arg1Of death,GBM
R9778 T14244 T14243 arg1Of death,cell
R9779 T14248 T14247 arg1Of WWOX,ectopic
R9780 T14248 T14249 arg1Of WWOX,fails
R9781 T14248 T14251 arg1Of WWOX,induce
R9782 T14249 T14245 arg1Of fails,First
R9783 T14249 T14246 arg1Of fails,","
R9784 T14251 T14249 arg2Of induce,fails
R9785 T14251 T14250 arg1Of induce,to
R9786 T14252 T14251 arg2Of apoptosis,induce
R9787 T14252 T14253 arg1Of apoptosis,of
R9788 T14255 T14253 arg2Of cells,of
R9789 T14255 T14254 arg1Of cells,GBM
R9790 T14255 T14256 arg1Of cells,expressing
R9791 T14260 T14256 arg2Of p53,expressing
R9792 T14260 T14257 arg1Of p53,endogenous
R9793 T14260 T14258 arg1Of p53,wild
R9794 T14260 T14259 arg1Of p53,type
R9795 T14261 T14262 arg1Of It,appears
R9796 T14265 T14264 arg1Of WWOX,ectopic
R9797 T14265 T14266 arg1Of WWOX,binds
R9798 T14265 T14269 arg1Of WWOX,antagonizes
R9799 T14266 T14267 arg1Of binds,and
R9800 T14267 T14272 arg1Of and,and
R9801 T14269 T14267 arg2Of antagonizes,and
R9802 T14269 T14268 arg1Of antagonizes,functionally
R9803 T14270 T14269 arg2Of p53,antagonizes
R9804 T14272 T14262 arg2Of and,appears
R9805 T14272 T14263 arg1Of and,that
R9806 T14272 T14271 arg1Of and,","
R9807 T14274 T14273 arg1Of proteins,both
R9808 T14274 T14275 arg1Of proteins,nullify
R9809 T14275 T14272 arg2Of nullify,and
R9810 T14277 T14276 arg1Of other’s,each
R9811 T14277 T14278 arg1Of other’s,function
R9812 T14277 T14280 arg1Of other’s,inducing
R9813 T14278 T14275 arg2Of function,nullify
R9814 T14278 T14279 arg1Of function,in
R9815 T14280 T14279 arg2Of inducing,in
R9816 T14281 T14280 arg2Of apoptosis,inducing
R9817 T14286 T14284 arg1Of interactions,no
R9818 T14286 T14285 arg1Of interactions,physical
R9819 T14286 T14287 arg1Of interactions,between
R9820 T14286 T14293 arg1Of interactions,are
R9821 T14286 T14294 arg2Of interactions,expected
R9822 T14290 T14288 arg1Of proteins,mutant
R9823 T14290 T14289 arg1Of proteins,p53
R9824 T14290 T14291 arg1Of proteins,and
R9825 T14291 T14287 arg2Of and,between
R9826 T14292 T14291 arg2Of WWOX,and
R9827 T14294 T14282 arg1Of expected,Second
R9828 T14294 T14283 arg1Of expected,","
R9829 T14294 T14293 arg2Of expected,are
R9830 T14294 T14295 arg1Of expected,in
R9831 T14297 T14295 arg2Of cells,in
R9832 T14297 T14296 arg1Of cells,GBM
R9833 T14301 T14300 arg1Of WWOX,ectopic
R9834 T14301 T14302 arg1Of WWOX,induce
R9835 T14302 T14298 arg1Of induce,Thus
R9838 T14303 T14302 arg2Of apoptosis,induce
R9839 T14307 T14304 arg2Of cells,in
R9840 T14307 T14305 arg1Of cells,mutant
R9841 T14307 T14306 arg1Of cells,p53-expressing
R9842 T14311 T14312 arg1Of WWOX,binds
R9843 T14312 T14310 arg1Of binds,whether
R9844 T14312 T14315 arg1Of binds,is
R9845 T14312 T14316 arg1Of binds,unknown
R9846 T14314 T14312 arg2Of isoforms,binds
R9847 T14314 T14313 arg1Of isoforms,p53
R9848 T14315 T14308 arg1Of is,Finally
R9849 T14315 T14309 arg1Of is,","
R9850 T14316 T14315 arg2Of unknown,is
R9851 T14322 T14319 arg1Of induction,whether
R9852 T14322 T14320 arg1Of induction,ectopic
R9853 T14322 T14321 arg1Of induction,WWOX
R9854 T14322 T14323 arg1Of induction,of
R9855 T14322 T14325 arg1Of induction,in
R9856 T14322 T14331 arg1Of induction,remains
R9857 T14322 T14333 arg1Of induction,be
R9858 T14322 T14334 arg2Of induction,established
R9859 T14324 T14323 arg2Of apoptosis,of
R9860 T14327 T14325 arg2Of cells,in
R9861 T14327 T14326 arg1Of cells,GBM
R9862 T14327 T14328 arg1Of cells,expressing
R9863 T14330 T14328 arg2Of isoforms,expressing
R9864 T14330 T14329 arg1Of isoforms,p53
R9865 T14331 T14317 arg1Of remains,Also
R9866 T14331 T14318 arg1Of remains,","
R9867 T14334 T14331 arg2Of established,remains
R9868 T14334 T14332 arg1Of established,to
R9869 T14334 T14333 arg2Of established,be
R9870 T14335 T14336 arg1Of TAD,","
R9871 T14335 T14339 arg1Of TAD,;
R9872 T14338 T14336 arg2Of domain,","
R9873 T14338 T14337 arg1Of domain,transactivation
R9874 T14340 T14339 arg2Of PrD,;
R9875 T14340 T14341 arg1Of PrD,","
R9876 T14340 T14344 arg1Of PrD,;
R9877 T14343 T14341 arg2Of domain,","
R9878 T14343 T14342 arg1Of domain,proline
R9879 T14345 T14344 arg2Of NLS,;
R9880 T14345 T14346 arg1Of NLS,","
R9881 T14345 T14350 arg1Of NLS,;
R9882 T14349 T14346 arg2Of signal,","
R9883 T14349 T14347 arg1Of signal,nuclear
R9884 T14349 T14348 arg1Of signal,localization
R9885 T14351 T14350 arg2Of OD,;
R9886 T14351 T14352 arg1Of OD,","
R9887 T14351 T14357 arg1Of OD,","
R9888 T14354 T14355 arg1Of domain,;
R9889 T14355 T14352 arg2Of ;,","
R9890 T14355 T14353 arg1Of ;,oligomerization
R9891 T14356 T14355 arg2Of BR,;
R9892 T14359 T14357 arg2Of region,","
R9893 T14359 T14358 arg1Of region,basic
R464 T915 T910 arg1Of patients,Glioblastoma
R465 T915 T911 arg1Of patients,multiforme
R474 T921 T920 arg2Of Friedman,(
R491 T938 T920 arg3Of ),(
R563 T1012 T1010 arg1Of therapy,current
R564 T1012 T1011 arg1Of therapy,standard
R565 T1012 T1013 arg1Of therapy,for
R566 T1012 T1016 arg1Of therapy,includes
R568 T1014 T1013 arg2Of GBM,for
R569 T1016 T1015 arg1Of includes,mainly
R570 T1019 T1017 arg1Of surgery,maximum
R571 T1019 T1018 arg1Of surgery,debulking

2_test

Id Subject Object Predicate Lexical cue
23459853-10914698-38778478 1229-1233 10914698 denotes 2000
23459853-19269895-38778479 1249-1253 19269895 denotes 2009
23459853-22244911-38778480 1270-1274 22244911 denotes 2012
23459853-10914698-38778481 1442-1446 10914698 denotes 2000
23459853-19269895-38778482 1462-1466 19269895 denotes 2009
23459853-22228201-38778483 1594-1598 22228201 denotes 2012
23459853-10914698-38778484 1806-1810 10914698 denotes 2000
23459853-20885105-38778485 1823-1827 20885105 denotes 2010
23459853-22228201-38778486 2095-2099 22228201 denotes 2012
23459853-22594898-38778487 2149-2153 22594898 denotes 2012
23459853-22675172-38778488 2171-2175 22675172 denotes 2012
23459853-22532597-38778489 2193-2197 22532597 denotes 2012
23459853-21406402-38778491 2354-2358 21406402 denotes 2011
23459853-14705733-38778493 2501-2505 14705733 denotes 2003
23459853-20587533-38778494 2668-2672 20587533 denotes 2010
23459853-23383259-38778495 2824-2828 23383259 denotes 2013
23459853-23028632-38778496 2939-2943 23028632 denotes 2012
23459853-16849758-38778497 3181-3185 16849758 denotes 2006
23459853-18757334-38778498 3200-3204 18757334 denotes 2008
23459853-20032445-38778499 3224-3228 20032445 denotes 2009
23459853-15322239-38778501 3450-3454 15322239 denotes 2004
23459853-16766259-38778502 3475-3479 16766259 denotes 2006
23459853-16819506-38778503 3494-3498 16819506 denotes 2007
23459853-16849758-38778504 3624-3628 16849758 denotes 2006
23459853-18757334-38778505 3643-3647 18757334 denotes 2008
23459853-18483356-38778506 3666-3670 18483356 denotes 2008
23459853-22837675-38778507 3904-3908 22837675 denotes 2012
23459853-20633539-38778508 4170-4174 20633539 denotes 2010
23459853-21909994-38778509 4257-4261 21909994 denotes 2012
23459853-22593187-38778510 4480-4484 22593187 denotes 2012
23459853-22156195-38778511 4772-4776 22156195 denotes 2012
23459853-21931801-38778512 4994-4998 21931801 denotes 2011
23459853-21406402-38778514 5331-5335 21406402 denotes 2011
23459853-21406402-38778516 5512-5516 21406402 denotes 2011
23459853-22912934-38778517 5697-5701 22912934 denotes 2012
23459853-22426504-38778518 5811-5815 22426504 denotes 2012
23459853-22532597-38778519 5923-5927 22532597 denotes 2012
23459853-22763762-38778520 6112-6116 22763762 denotes 2012
23459853-21988793-38778521 6350-6354 21988793 denotes 2011
23459853-22854781-38778522 6369-6373 22854781 denotes 2012
23459853-23106300-38778523 6496-6500 23106300 denotes 2012
23459853-22898080-38778524 6792-6796 22898080 denotes 2012
23459853-11058590-38778525 7203-7207 11058590 denotes 2001
23459853-17142102-38778526 7209-7213 17142102 denotes 2007
23459853-20542955-38778527 7215-7219 20542955 denotes 2010
23459853-15131042-38778528 7237-7241 15131042 denotes 2004
23459853-17909041-38778529 7243-7247 17909041 denotes 2007
23459853-17567906-38778530 7262-7266 17567906 denotes 2007
23459853-22201747-38778531 7282-7286 22201747 denotes 2012
23459853-14555208-38778533 7784-7788 14555208 denotes 2003
23459853-17142102-38778534 7790-7794 17142102 denotes 2007
23459853-21731849-38778535 7813-7817 21731849 denotes 2011
23459853-22201747-38778536 7833-7837 22201747 denotes 2012
23459853-17289881-38778537 9379-9383 17289881 denotes 2007
23459853-15168591-38778538 9434-9438 15168591 denotes 2004
23459853-15131042-38778539 9476-9480 15131042 denotes 2004
23459853-15073125-38778540 9520-9524 15073125 denotes 2004
23459853-15073846-38778541 9559-9563 15073846 denotes 2004
23459853-17909041-38778542 9581-9585 17909041 denotes 2007
23459853-20535528-38778543 9631-9635 20535528 denotes 2011
23459853-16223882-38778544 9714-9718 16223882 denotes 2005
23459853-18460020-38778545 9757-9761 18460020 denotes 2008
23459853-19484134-38778546 9798-9802 19484134 denotes 2009
23459853-17142102-38778547 9974-9978 17142102 denotes 2007
23459853-22201747-38778548 9994-9998 22201747 denotes 2012
23459853-22201747-38778549 10206-10210 22201747 denotes 2012
23459853-19918364-38778550 10378-10382 19918364 denotes 2009
23459853-11058590-38778551 10614-10618 11058590 denotes 2001
23459853-14555208-38778552 10620-10624 14555208 denotes 2003
23459853-17142102-38778554 10635-10639 17142102 denotes 2007
23459853-20542955-38778555 10641-10645 20542955 denotes 2010
23459853-19465938-38778557 11089-11093 19465938 denotes 2009
23459853-22736928-38778558 11205-11209 22736928 denotes 2012
23459853-17142102-38778559 11253-11257 17142102 denotes 2007
23459853-20542955-38778560 11259-11263 20542955 denotes 2010
23459853-22201747-38778561 11279-11283 22201747 denotes 2012
23459853-11058590-38778562 11468-11472 11058590 denotes 2001
23459853-17142102-38778563 11789-11793 17142102 denotes 2007
23459853-20542955-38778564 11795-11799 20542955 denotes 2010
23459853-21901168-38778565 11848-11852 21901168 denotes 2011
23459853-22343622-38778566 12131-12135 22343622 denotes 2012
23459853-19484134-38778567 12472-12476 19484134 denotes 2009
23459853-19366691-38778568 12594-12598 19366691 denotes 2009
23459853-16438931-38778569 12631-12635 16438931 denotes 2006
23459853-19366691-38778570 12848-12852 19366691 denotes 2009
23459853-20463001-38778571 12983-12987 20463001 denotes 2010
23459853-20463001-38778572 13341-13345 20463001 denotes 2010
23459853-19776742-38778573 13513-13517 19776742 denotes 2009
23459853-9546431-38778574 13642-13646 9546431 denotes 1998
23459853-10206959-38778575 13686-13690 10206959 denotes 1999
23459853-15340061-38778576 15021-15025 15340061 denotes 2004
23459853-16440000-38778577 15039-15043 16440000 denotes 2006
23459853-16131611-38778578 15139-15143 16131611 denotes 2005
23459853-17637683-38778579 15154-15158 17637683 denotes 2007
23459853-16131611-38778580 15390-15394 16131611 denotes 2005
23459853-16131611-38778581 15556-15560 16131611 denotes 2005
23459853-20689555-38778582 15671-15675 20689555 denotes 2011
23459853-8519417-38778583 15991-15995 8519417 denotes 1995
23459853-11280752-38778584 16012-16016 11280752 denotes 2001
23459853-21156285-38778585 16036-16040 21156285 denotes 2010
23459853-20593219-38778586 16057-16061 20593219 denotes 2011
23459853-20593219-38778587 16198-16202 20593219 denotes 2011
23459853-20593219-38778588 16267-16271 20593219 denotes 2011
23459853-20535528-38778589 16430-16434 20535528 denotes 2011
23459853-22898080-38778590 16616-16620 22898080 denotes 2012
23459853-22898080-38778591 16830-16834 22898080 denotes 2012
23459853-21901168-38778593 17952-17956 21901168 denotes 2011
23459853-22343622-38778594 18345-18349 22343622 denotes 2012
23459853-19484134-38778595 18601-18605 19484134 denotes 2009
23459853-22898080-38778596 18787-18791 22898080 denotes 2012
23459853-11058590-38778597 18940-18944 11058590 denotes 2001
23459853-14555208-38778598 18946-18950 14555208 denotes 2003
23459853-17142102-38778600 18961-18965 17142102 denotes 2007
23459853-20542955-38778601 18967-18971 20542955 denotes 2010
23459853-22534828-38778602 18973-18977 22534828 denotes 2012
23459853-16115915-38778603 19431-19435 16115915 denotes 2005
23459853-15800333-38778604 20022-20026 15800333 denotes 2005
23459853-14623895-38778605 20129-20133 14623895 denotes 2004
23459853-22726066-38778606 20151-20155 22726066 denotes 2012
23459853-12174938-38778607 20255-20259 12174938 denotes 2002
23459853-12684632-38778608 20276-20280 12684632 denotes 2003
23459853-22582165-38778609 20299-20303 22582165 denotes 2012
23459853-19458077-38778610 20481-20485 19458077 denotes 2009
23459853-21731849-38778611 20504-20508 21731849 denotes 2011
23459853-22534828-38778612 20702-20706 22534828 denotes 2012
23459853-21731849-38778613 21773-21777 21731849 denotes 2011
23459853-22201747-38778614 21793-21797 22201747 denotes 2012
23459853-21075834-38778615 21953-21957 21075834 denotes 2011
23459853-22835215-38778616 22161-22165 22835215 denotes 2012

UBERON-AE

Id Subject Object Predicate Lexical cue
T14071 13858-13865 http://purl.obolibrary.org/obo/UBERON_0012131 denotes central
T12774 9110-9114 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
T12773 8952-8956 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
T12772 8846-8850 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
T12771 7796-7799 http://purl.obolibrary.org/obo/UBERON_2000711 denotes Del
T9742 21756-21759 http://purl.obolibrary.org/obo/UBERON_2000711 denotes Del
T9741 20487-20490 http://purl.obolibrary.org/obo/UBERON_2000711 denotes Del
T9740 21546-21552 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T9739 19857-19863 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
T9738 21540-21545 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T9737 21383-21388 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T9736 20090-20095 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T9735 19851-19856 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T9734 18423-18428 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T3814 7180-7184 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T3822 12739-12743 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
T3821 12674-12678 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
T3820 12574-12578 http://purl.obolibrary.org/obo/UBERON_3000101 denotes Hyal
T3819 10344-10349 http://purl.obolibrary.org/obo/UBERON_0001021 denotes nerve
T3818 10336-10349 http://purl.obolibrary.org/obo/UBERON_0001322 denotes sciatic nerve
T3817 9527-9533 http://purl.obolibrary.org/obo/UBERON_0000310 denotes breast
T3816 9686-9690 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T3815 9348-9352 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
T874 4554-4559 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
T873 2027-2038 http://purl.obolibrary.org/obo/UBERON_0003104 denotes mesenchymal

GO-BP

Id Subject Object Predicate Lexical cue
T136 0-16 http://purl.obolibrary.org/obo/GO_0051726 denotes Tumor Suppressor
T139 46-61 http://purl.obolibrary.org/obo/GO_0042493 denotes Drug Resistance
T14145 14129-14134 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T14144 14124-14134 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T14143 14780-14786 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T14142 13945-13951 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T14141 14767-14779 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T14140 13932-13944 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T14139 14709-14724 http://purl.obolibrary.org/obo/GO_2000144 denotes transactivation
T14138 13801-13816 http://purl.obolibrary.org/obo/GO_2000144 denotes transactivation
T14137 14630-14639 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T14136 14495-14504 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T14135 14361-14370 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T14134 14172-14181 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T14133 13745-13754 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T14132 14617-14639 http://purl.obolibrary.org/obo/GO_0006915 denotes induction of apoptosis
T14131 14495-14504 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T14130 14361-14370 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T14129 14172-14181 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T14128 13745-13754 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T12923 9197-9200 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T12922 9166-9169 http://purl.obolibrary.org/obo/GO_0050321 denotes GSK
T12921 8780-8785 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T12920 8775-8785 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T12919 8612-8626 http://purl.obolibrary.org/obo/GO_0051170 denotes nuclear import
T12918 8563-8577 http://purl.obolibrary.org/obo/GO_0007165 denotes signal pathway
T12917 8318-8331 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T12916 8269-8278 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T12915 8269-8278 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T12914 8002-8017 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12913 7955-7970 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12912 7714-7726 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T12911 8563-8569 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T12910 7727-7733 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T12909 7564-7573 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T9949 22297-22316 http://purl.obolibrary.org/obo/GO_0051828 denotes growth and invasion
T9948 22297-22316 http://purl.obolibrary.org/obo/GO_0044409 denotes growth and invasion
T9947 22297-22316 http://purl.obolibrary.org/obo/GO_0036267 denotes growth and invasion
T9946 22088-22098 http://purl.obolibrary.org/obo/GO_0006096 denotes glycolysis
T9945 21993-22008 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T9944 22255-22272 http://purl.obolibrary.org/obo/GO_1903409 denotes generation of ROS
T9943 21918-21935 http://purl.obolibrary.org/obo/GO_1903409 denotes generation of ROS
T9942 21882-21906 http://purl.obolibrary.org/obo/GO_0045333 denotes metabolism and oxidative
T9941 21706-21721 http://purl.obolibrary.org/obo/GO_0006694 denotes steroidogenesis
T9940 21882-21892 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T9939 21678-21688 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T9938 21451-21459 http://purl.obolibrary.org/obo/GO_0007610 denotes behavior
T9937 22292-22303 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T9936 20624-20639 http://purl.obolibrary.org/obo/GO_0016049 denotes growth and cell
T9935 22519-22533 http://purl.obolibrary.org/obo/GO_0016477 denotes cell migration
T9934 20635-20649 http://purl.obolibrary.org/obo/GO_0016477 denotes cell migration
T9933 20359-20373 http://purl.obolibrary.org/obo/GO_0016477 denotes cell migration
T9932 19920-19929 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T9931 19892-19896 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T9930 19865-19880 http://purl.obolibrary.org/obo/GO_0007165 denotes Signal pathways
T9929 19865-19871 http://purl.obolibrary.org/obo/GO_0023052 denotes Signal
T9928 22398-22415 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressors
T9927 19159-19176 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressors
T9926 22297-22303 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T9925 22103-22109 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T9924 20624-20630 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T9923 19630-19636 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T9922 18402-18408 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T9921 19999-20004 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T9920 18317-18322 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T9919 18059-18064 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T9918 18312-18322 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T9917 18054-18064 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T9916 20661-20670 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T9915 18891-18900 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T9914 18709-18718 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T9913 18662-18671 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T9912 18452-18461 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T9911 18168-18177 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T9910 17909-17918 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T9909 17799-17808 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T9908 20661-20670 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T9907 18891-18900 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T9906 18709-18718 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T9905 18662-18671 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T9904 18452-18461 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T9903 18168-18177 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T9902 17909-17918 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T9901 17799-17808 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T8502 17081-17096 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T8501 16582-16599 http://purl.obolibrary.org/obo/GO_0006309 denotes DNA fragmentation
T8500 17580-17589 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T8499 17549-17558 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T8498 17441-17450 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T8497 16722-16731 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T8496 16495-16504 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T8495 17580-17589 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T8494 17549-17558 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T8493 17441-17450 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T8492 16722-16731 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T8491 16495-16504 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T8490 16403-16414 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T7592 15745-15760 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T7591 15596-15611 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T7590 15807-15816 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T7589 15529-15538 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T7588 15452-15461 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T7587 15807-15816 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T7586 15529-15538 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T7585 15452-15461 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T7584 15294-15318 http://purl.obolibrary.org/obo/GO_0051647 denotes localized in the nucleus
T7583 15346-15355 http://purl.obolibrary.org/obo/GO_0051179 denotes localized
T7582 15294-15303 http://purl.obolibrary.org/obo/GO_0051179 denotes localized
T7581 15200-15209 http://purl.obolibrary.org/obo/GO_0051179 denotes localized
T7580 14994-15005 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T7579 14923-14931 http://purl.obolibrary.org/obo/GO_0045292 denotes splicing
T7578 14918-14931 http://purl.obolibrary.org/obo/GO_0000398 denotes mRNA splicing
T7577 14918-14931 http://purl.obolibrary.org/obo/GO_0000394 denotes mRNA splicing
T7576 14918-14931 http://purl.obolibrary.org/obo/GO_0000374 denotes mRNA splicing
T7575 14918-14931 http://purl.obolibrary.org/obo/GO_0000373 denotes mRNA splicing
T7574 14918-14931 http://purl.obolibrary.org/obo/GO_0000372 denotes mRNA splicing
T6844 13558-13571 http://purl.obolibrary.org/obo/GO_0048870 denotes cell motility
T6843 13479-13487 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T6842 13453-13459 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T6841 13382-13387 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T6840 13377-13396 http://purl.obolibrary.org/obo/GO_0036474 denotes cell death response
T6839 13377-13387 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T6838 13361-13373 http://purl.obolibrary.org/obo/GO_0043066 denotes pro-survival
T6837 13142-13158 http://purl.obolibrary.org/obo/GO_0033673 denotes kinase inhibitor
T6836 13125-13131 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T6835 12954-12964 http://purl.obolibrary.org/obo/GO_0008152 denotes metabolism
T6834 12939-12949 http://purl.obolibrary.org/obo/GO_0006281 denotes DNA repair
T6833 13074-13091 http://purl.obolibrary.org/obo/GO_0007050 denotes cell cycle arrest
T6832 12908-12925 http://purl.obolibrary.org/obo/GO_0007050 denotes cell cycle arrest
T6831 13074-13091 http://purl.obolibrary.org/obo/GO_0071850 denotes cell cycle arrest
T6830 12908-12925 http://purl.obolibrary.org/obo/GO_0071850 denotes cell cycle arrest
T6829 13074-13091 http://purl.obolibrary.org/obo/GO_0071156 denotes cell cycle arrest
T6828 12908-12925 http://purl.obolibrary.org/obo/GO_0071156 denotes cell cycle arrest
T6827 13074-13084 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T6826 12908-12918 http://purl.obolibrary.org/obo/GO_0007049 denotes cell cycle
T6825 13195-13204 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T6824 12897-12906 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T6823 13195-13204 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T6822 12897-12906 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4045 10271-10283 http://purl.obolibrary.org/obo/GO_0043066 denotes pro-survival
T4044 11045-11060 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T4043 10417-10430 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4042 10284-10297 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4041 10065-10078 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T4040 9676-9690 http://purl.obolibrary.org/obo/GO_0060437 denotes growth of lung
T4039 12651-12657 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T4038 12110-12116 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T4037 9676-9682 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T4036 12387-12396 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4035 11982-11991 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4034 11764-11773 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4033 11384-11393 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4032 11123-11132 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4031 6744-6753 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T4030 12387-12396 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4029 11982-11991 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4028 11764-11773 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4027 11384-11393 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4026 11123-11132 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4025 6744-6753 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T4024 6686-6703 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressors
T4065 12717-12726 http://purl.obolibrary.org/obo/GO_0009058 denotes formation
T4064 12428-12457 http://purl.obolibrary.org/obo/GO_0006957 denotes complement activation pathway
T4063 12428-12457 http://purl.obolibrary.org/obo/GO_0006958 denotes complement activation pathway
T4062 12428-12449 http://purl.obolibrary.org/obo/GO_0006956 denotes complement activation
T4061 12253-12284 http://purl.obolibrary.org/obo/GO_0032976 denotes releasing from the mitochondria
T4060 12105-12116 http://purl.obolibrary.org/obo/GO_0016049 denotes cell growth
T4059 12048-12060 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK activity
T4058 11500-11505 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T4057 11349-11357 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T4056 11349-11357 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T4055 11495-11505 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T4054 11349-11357 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T4053 11349-11357 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T4052 10973-10983 http://purl.obolibrary.org/obo/GO_0051235 denotes sequesters
T4051 10887-10904 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T4050 12706-12712 http://purl.obolibrary.org/obo/GO_0023052 denotes signal
T4049 10887-10896 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T4048 12344-12359 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4047 11650-11665 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T4046 10522-10537 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T2017 6000-6011 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T2016 5409-5421 http://purl.obolibrary.org/obo/GO_0009058 denotes biosynthesis
T2015 5402-5421 http://purl.obolibrary.org/obo/GO_0009435 denotes NAD(+) biosynthesis
T2014 5106-5115 http://purl.obolibrary.org/obo/GO_0046960 denotes sensitize
T2013 4909-4929 http://purl.obolibrary.org/obo/GO_0008535 denotes cytochrome c oxidase
T2012 4909-4929 http://purl.obolibrary.org/obo/GO_0004129 denotes cytochrome c oxidase
T2011 4618-4629 http://purl.obolibrary.org/obo/GO_0016798 denotes glycosylase
T2010 5377-5397 http://purl.obolibrary.org/obo/GO_0006284 denotes base excision repair
T2009 5177-5197 http://purl.obolibrary.org/obo/GO_0006284 denotes base excision repair
T2008 4572-4592 http://purl.obolibrary.org/obo/GO_0006284 denotes base excision repair
T2007 3945-3956 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T2006 3807-3818 http://purl.obolibrary.org/obo/GO_0032259 denotes methylation
T2005 4397-4406 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2004 3701-3710 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T2003 3739-3742 http://purl.obolibrary.org/obo/GO_0006298 denotes MMR
T2002 3536-3539 http://purl.obolibrary.org/obo/GO_0006298 denotes MMR
T2001 3341-3344 http://purl.obolibrary.org/obo/GO_0006298 denotes MMR
T2000 3314-3329 http://purl.obolibrary.org/obo/GO_0006298 denotes mismatch repair
T1999 3300-3329 http://purl.obolibrary.org/obo/GO_0032425 denotes activation of mismatch repair
T1998 5639-5643 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T1997 5047-5051 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T1996 3971-3975 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T1995 3926-3930 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T1994 3829-3833 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T1993 3520-3524 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T1992 3260-3264 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T1991 3158-3162 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T1990 4208-4220 http://purl.obolibrary.org/obo/GO_0043066 denotes pro-survival
T1989 2742-2754 http://purl.obolibrary.org/obo/GO_0043066 denotes pro-survival
T1988 2595-2611 http://purl.obolibrary.org/obo/GO_0048102 denotes autophagic death
T1987 3426-3431 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T1986 2606-2611 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T1985 2478-2483 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T1984 3421-3431 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T1983 2473-2483 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T1982 4147-4156 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1981 2911-2920 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1980 2783-2792 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1979 2453-2462 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T1978 3411-3431 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptotic cell death
T1977 2911-2920 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T1976 2783-2792 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T1975 2453-2462 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T1974 3043-3052 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T1973 2729-2738 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T1972 2430-2439 http://purl.obolibrary.org/obo/GO_0006914 denotes autophagy
T1971 2016-2049 http://purl.obolibrary.org/obo/GO_0001837 denotes epithelial-mesenchymal transition
T1970 2016-2049 http://purl.obolibrary.org/obo/GO_0060317 denotes epithelial-mesenchymal transition
T1969 2016-2049 http://purl.obolibrary.org/obo/GO_0060231 denotes epithelial-mesenchymal transition
T1968 2016-2049 http://purl.obolibrary.org/obo/GO_0010717 denotes epithelial-mesenchymal transition
T1967 1993-2014 http://purl.obolibrary.org/obo/GO_0016575 denotes histone deacetylation
T144 1071-1076 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T143 1066-1076 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T142 605-614 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T141 605-614 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T140 387-402 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T138 356-372 http://purl.obolibrary.org/obo/GO_0051726 denotes tumor suppressor
T137 89-105 http://purl.obolibrary.org/obo/GO_0051726 denotes Tumor suppressor

GO-MF

Id Subject Object Predicate Lexical cue
T14148 13870-13877 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14147 13866-13884 http://purl.obolibrary.org/obo/GO_0000975 denotes DNA-binding region
T14146 13866-13877 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA-binding
T12929 9197-9200 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T12928 9166-9169 http://purl.obolibrary.org/obo/GO_0050321 denotes GSK
T12927 8388-8414 http://purl.obolibrary.org/obo/GO_0050699 denotes WW domain, and the binding
T12926 8581-8588 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12925 8407-8414 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12924 7906-7913 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T9957 21075-21083 http://purl.obolibrary.org/obo/GO_0043495 denotes anchored
T9956 19892-19896 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T9955 19023-19034 http://purl.obolibrary.org/obo/GO_0002039 denotes p53-binding
T9954 19027-19043 http://purl.obolibrary.org/obo/GO_0005515 denotes binding proteins
T9953 17741-17757 http://purl.obolibrary.org/obo/GO_0005515 denotes Binding proteins
T9952 19027-19034 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T9951 17741-17748 http://purl.obolibrary.org/obo/GO_0005488 denotes Binding
T8506 17211-17234 http://purl.obolibrary.org/obo/GO_0005515 denotes binding of this protein
T8505 17211-17218 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T8504 17148-17155 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T8503 17135-17155 http://purl.obolibrary.org/obo/GO_0035326 denotes enhances the binding
T6845 13125-13131 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T4076 12547-12554 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T4075 12500-12508 http://purl.obolibrary.org/obo/GO_0043495 denotes anchored
T4071 12240-12250 http://purl.obolibrary.org/obo/GO_0045155 denotes cytochrome
T4070 12240-12250 http://purl.obolibrary.org/obo/GO_0045154 denotes cytochrome
T4069 12240-12250 http://purl.obolibrary.org/obo/GO_0045153 denotes cytochrome
T4068 12048-12060 http://purl.obolibrary.org/obo/GO_0004708 denotes MEK activity
T4067 11343-11364 http://purl.obolibrary.org/obo/GO_0043120 denotes tumor necrosis factor
T4066 11343-11364 http://purl.obolibrary.org/obo/GO_0005164 denotes tumor necrosis factor
T2033 4909-4929 http://purl.obolibrary.org/obo/GO_0004129 denotes cytochrome c oxidase
T2032 4909-4919 http://purl.obolibrary.org/obo/GO_0045158 denotes cytochrome
T2031 4909-4919 http://purl.obolibrary.org/obo/GO_0045157 denotes cytochrome
T2030 4909-4919 http://purl.obolibrary.org/obo/GO_0045156 denotes cytochrome
T2029 4909-4921 http://purl.obolibrary.org/obo/GO_0045155 denotes cytochrome c
T2028 4909-4919 http://purl.obolibrary.org/obo/GO_0045154 denotes cytochrome
T2027 4909-4919 http://purl.obolibrary.org/obo/GO_0045153 denotes cytochrome
T2026 4618-4629 http://purl.obolibrary.org/obo/GO_0016798 denotes glycosylase
T2025 5639-5643 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T2024 5047-5051 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T2023 3971-3975 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T2022 3926-3930 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T2021 3829-3833 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T2020 3520-3524 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T2019 3260-3264 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T2018 3158-3162 http://purl.obolibrary.org/obo/GO_0003908 denotes MGMT
T4074 12240-12250 http://purl.obolibrary.org/obo/GO_0045158 denotes cytochrome
T4073 12240-12250 http://purl.obolibrary.org/obo/GO_0045157 denotes cytochrome
T4072 12240-12250 http://purl.obolibrary.org/obo/GO_0045156 denotes cytochrome

GO-CC

Id Subject Object Predicate Lexical cue
T14154 14647-14652 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14153 14530-14535 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14152 14462-14467 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14151 14189-14194 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14150 14124-14128 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T14149 13740-13744 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T12936 8702-8706 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T12935 8478-8487 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T12934 9010-9017 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T12933 8251-8258 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T12932 8750-8762 http://purl.obolibrary.org/obo/GO_0005739 denotes mitochondria
T12931 8235-8247 http://purl.obolibrary.org/obo/GO_0005739 denotes mitochondria
T12930 7893-7905 http://purl.obolibrary.org/obo/GO_0005739 denotes mitochondria
T12939 9197-9200 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T12938 8812-8820 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T12937 8775-8779 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T9984 21105-21117 http://purl.obolibrary.org/obo/GO_0005856 denotes cytoskeleton
T9983 21096-21104 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T9982 21091-21104 http://purl.obolibrary.org/obo/GO_0005886 denotes cell membrane
T9981 21075-21104 http://purl.obolibrary.org/obo/GO_0036405 denotes anchored on the cell membrane
T9980 22635-22640 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9979 22466-22471 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9978 22238-22243 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9977 22054-22059 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9976 21484-21489 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9975 21389-21394 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9974 21321-21326 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9973 21280-21285 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9972 21238-21243 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9971 21182-21187 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9970 21133-21138 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9969 20993-20998 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9968 20895-20900 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9967 20732-20737 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9966 20681-20686 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9965 20458-20463 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9964 20036-20041 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9963 19970-19975 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9962 18729-18734 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9961 18500-18505 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9960 18202-18207 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9959 17933-17938 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T9958 17836-17841 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8514 16755-16767 http://purl.obolibrary.org/obo/GO_0005739 denotes mitochondria
T8513 17515-17520 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8512 17296-17301 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8511 16949-16954 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8510 16743-16748 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8509 16529-16534 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8508 16124-16129 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8507 15968-15973 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T7597 15363-15372 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T7596 15323-15332 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T7595 15261-15270 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T7594 15311-15318 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T7593 15224-15231 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T6850 13558-13562 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6849 13413-13417 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6848 13377-13381 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6847 13074-13078 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T6846 12908-12912 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4091 12779-12786 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T4090 12525-12537 http://purl.obolibrary.org/obo/GO_0005856 denotes cytoskeleton
T4089 12516-12524 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T4088 12500-12524 http://purl.obolibrary.org/obo/GO_0031225 denotes anchored in the membrane
T4087 12022-12032 http://purl.obolibrary.org/obo/GO_0045121 denotes lipid raft
T4086 12272-12284 http://purl.obolibrary.org/obo/GO_0005739 denotes mitochondria
T4085 11959-11971 http://purl.obolibrary.org/obo/GO_0005739 denotes mitochondria
T4084 11728-11740 http://purl.obolibrary.org/obo/GO_0005739 denotes mitochondria
T4083 10997-11006 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasm
T4082 6934-6944 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosome
T4081 12382-12386 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T4080 12173-12178 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4079 11829-11834 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4078 11187-11192 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T4077 6770-6775 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2047 4809-4826 http://purl.obolibrary.org/obo/GO_0070469 denotes respiratory chain
T2046 4795-4826 http://purl.obolibrary.org/obo/GO_0097249 denotes mitochondrial respiratory chain
T2045 4795-4826 http://purl.obolibrary.org/obo/GO_0005746 denotes mitochondrial respiratory chain
T2044 1947-1964 http://purl.obolibrary.org/obo/GO_1990391 denotes DNA damage repair
T2043 6565-6570 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2042 6465-6470 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2041 6443-6448 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2040 6403-6408 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2039 6131-6136 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2038 4239-4244 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2037 3851-3856 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2036 2800-2805 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2035 1972-1977 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T2034 1916-1921 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T147 1066-1070 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T146 637-642 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T145 442-447 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T79 0-78 Sentence denotes Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas
T14080 14704-14833 Sentence denotes TAD, transactivation domain; PrD, proline domain; NLS, nuclear localization signal; OD, oligomerization domain; BR, basic region.
T14079 14590-14703 Sentence denotes Also, whether ectopic WWOX induction of apoptosis in GBM cells expressing p53 isoforms remains to be established.
T14078 14537-14589 Sentence denotes Finally, whether WWOX binds p53 isoforms is unknown.
T14077 14469-14536 Sentence denotes Thus, ectopic WWOX induce apoptosis in mutant p53-expressing cells.
T14076 14372-14468 Sentence denotes Second, no physical interactions between mutant p53 proteins and WWOX are expected in GBM cells.
T14075 14232-14371 Sentence denotes It appears that ectopic WWOX binds and functionally antagonizes p53, and both proteins nullify each other’s function in inducing apoptosis.
T14074 14136-14231 Sentence denotes First, ectopic WWOX fails to induce apoptosis of GBM cells expressing endogenous wild type p53.
T14073 14000-14135 Sentence denotes N-terminal deletion mutants of p53 are also shown. (B) Three likely scenarios are proposed for WWOX and p53 to regulate GBM cell death.
T14072 13720-13999 Sentence denotes p53 and WWOX in GBM cell apoptosis. (A) Full-length p53 possesses two N-terminal transactivation acidic domains, a proline-rich domain, a central DNA-binding region, and a C-terminal domain, containing a nuclear localization signal, an oligomerization domain, and a basic region.
T12789 9067-9219 Sentence denotes Ack1, activated Cdc42-associated kinase 1; Hyal-2, hyaluronoglucosaminidase 2; CKI, casein kinase; GSK, glycogen synthase kinase; PKA, protein kinase A.
T12788 8918-9066 Sentence denotes In response to TGF-β1, WWOX binds Hyal-2 and forms a complex, followed by relocating to the nucleus and enhancing the SMAD-driven promoter activity.
T12787 8787-8917 Sentence denotes WWOX is recruited to the membrane area by association with Hyal-2 and phospho-Ezrin. Hyal-2 is an alternative receptor for TGF-β1.
T12786 8628-8786 Sentence denotes Phorbol ester stimulates the dissociation of MEK/WWOX complex in Jurkat T cell, and the released WWOX translocates to the mitochondria for causing cell death.
T12785 8524-8627 Sentence denotes WWOX participates in the Wnt/β-catenin signal pathway by binding Dvl and inhibiting its nuclear import.
T12784 8489-8523 Sentence denotes WWOX binds Tau via its SDR domain.
T12783 8280-8488 Sentence denotes WWOX also binds PPxY motif-containing transcription factors, such as RUNX2, c-Jun, and ERBB4, via its first WW domain, and the binding blocks the activity of these proteins by retaining them in the cytoplasm.
T12782 8193-8279 Sentence denotes The WWOX/p53 complex then translocates to mitochondria or nucleus to induce apoptosis.
T12781 8121-8192 Sentence denotes Upon stress stimulation, WWOX is phosphorylated in Tyr33 and binds p53.
T12780 7996-8120 Sentence denotes Other phosphorylation sites predicted by NetPhos 2.0 Server are Tyr6, Thr12, Ser14, Tyr61, Tyr293, and Thr3B3, respectively.
T12779 7922-7995 Sentence denotes There are two conserved tyrosine phosphorylation sites, Tyr33 and Tyr287.
T12778 7866-7921 Sentence denotes The SDR domain possesses a mitochondria-binding region.
T12777 7704-7865 Sentence denotes A nuclear localization signal (NLS) is in between the WW domains (Chang et al., 2003, 2007; Del Mare et al., 2011; Salah et al., 2012; Su et al., 2012; reviews).
T12776 7575-7703 Sentence denotes WWOX contains two N-terminal WW domains, a C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domain, and a D3 region.
T12775 7511-7574 Sentence denotes Schematic diagrams of WWOX structure and its role in signaling.
T12590 22978-23150 Sentence denotes The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
T12465 22664-22945 Sentence denotes Ming-Fu Chiang and Chun-I Sze wrote the sections dealing with TMZ; Pei-Yi Chou wrote the review sections for p53 and WWOX and designed graphs; Wan-Jen Wang managed citations; Nan-Shan Chang conceived ideas, wrote and thoroughly revised the manuscript, and discussed with coauthors.
T9777 22473-22641 Sentence denotes We have shown the role of WWOX in controlling cell migration and metabolic alterations, and discussed the effects of WWOX deficiency and TMZ resistance in cancer cells.
T9776 22318-22472 Sentence denotes In summary, in this perspective article we have discussed the potential role of tumor suppressors p53 and WWOX in regulating TMZ sensitivity in GBM cells.
T9775 22168-22317 Sentence denotes Conceivably, WWOX is likely to override glucose consumption in cancer cells and exerts generation of ROS to curb the cancer cell growth and invasion.
T9774 21960-22167 Sentence denotes Under UV stress, functional Wwox gene expression induces ROS production in Drosophila. Cancer cells are known to overly utilize glycolysis for growth advantage – the so-called Warburg (Moncada et al., 2012).
T9773 21800-21959 Sentence denotes In a Drosophila model, Wwox is shown to participate in pathways involving aerobic metabolism and oxidative stress for generation of ROS (O’Keefe et al., 2011).
T9772 21581-21799 Sentence denotes Metabolic alterations have been shown in Wwox knockout mice, including postnatal lethality, bone metabolism defects, ataxia, steroidogenesis, and generation of osteosarcomas (Del Mare et al., 2011; Salah et al., 2012).
T9771 21425-21580 Sentence denotes Apparently, the migratory behavior of WWOX-negative glioma cells may account for the diffuse invasion into distant brain tissue (Chou et al., unpublished).
T9770 21287-21424 Sentence denotes Conceivably, WWOX-negative glioma cells migrate individually and turn away from WWOX-expressing brain cells to low WWOX expression areas.
T9769 21048-21286 Sentence denotes While a portion of WWOX is anchored on the cell membrane/cytoskeleton, WWOX-negative cells lose recognition by parental WWOX-positive cells, and this increases the mobility of WWOX-negative cells to move away from the WWOX-positive cells.
T9768 20970-21047 Sentence denotes In contrast, wild type cells migrate collectively (Chou et al., unpublished).
T9767 20818-20969 Sentence denotes This assumption is based upon our observations that mouse Wwox gene knockout cells (e.g., embryonic fibroblasts) migrate individually and aggressively.
T9766 20709-20817 Sentence denotes We believe that glioma cells, with stem cell-like properties, migrate individually rather than collectively.
T9765 20511-20708 Sentence denotes Ectopic expression of TIAF1 (TGF-β-induced antiapoptotic factor), p53, and WWOX suppresses anchorage-independent growth and cell migration and causes apoptosis in cancer cells (Chang et al., 2012).
T9764 20375-20510 Sentence denotes For example, loss of WWOX facilitates migration of ovarian cancer and osteosarcoma cells (Gourley et al., 2009; Del Mare et al., 2011).
T9763 20306-20374 Sentence denotes Also, lack of WWOX expression is expected to enhance cell migration.
T9762 20029-20305 Sentence denotes Glioma cells possess CD44 as a receptor for interacting with brain matrix hyaluronan (Murai et al., 2004; Yoshida et al., 2012), and secrete hyaluronidases and metalloproteinases to facilitate their migration (Delpech et al., 2002; Junker et al., 2003; Hagemann et al., 2012).
T9761 19865-20028 Sentence denotes Signal pathways, involving PI3K, Akt, mTOR, NF-κB, and autophagy, are believed to confer these migrating cells resistant to apoptotic death (Lefranc et al., 2005).
T9760 19752-19864 Sentence denotes One of the unique characteristics for malignant gliomas is their diffuse infiltration into distant brain tissue.
T9759 19638-19751 Sentence denotes Whether endogenous WWOX counteracts with the function of endogenous p53 is unknown and remains to be established.
T9758 19563-19637 Sentence denotes Or, do they counteract each other’s function, thus allowing cancer growth?
T9757 19465-19562 Sentence denotes Do these proteins act synergistically in blocking cancer progression but lose control eventually?
T9756 19222-19464 Sentence denotes However, it is not surprising to find that many tumor suppressor proteins, e.g., p53, WWOX, Smad4, PTEN, PP2A, and etc., are significantly upregulated during the early stage of cancer progression (Lai et al., 2005; Chang et al., unpublished).
T9755 19131-19221 Sentence denotes Functional antagonism among tumor suppressors has never been documented in the literature.
T9754 18997-19130 Sentence denotes A likely scenario is that p53-binding proteins, which are present in GBMs, may interfere with the apoptotic function of WWOX and p53.
T9753 18794-18996 Sentence denotes In most cases, we have shown that p53 functionally interacts with WWOX, and both proteins induce apoptosis in a synergistic manner (Chang et al., 2001, 2003, 2005a,b, 2007, 2010, 2012; Su et al., 2012).
T9752 18673-18793 Sentence denotes Failure of ectopic WWOX in inducing apoptosis of glioma cells possessing wild type p53 is unusual (Chiang et al., 2012).
T9751 18608-18672 Sentence denotes In this event, ectopic WWOX is activated for inducing apoptosis.
T9750 18410-18607 Sentence denotes For example, serum complement C1q induces apoptosis of prostate cancer and neuroblastomas cells without participation of downstream proteins in the classical activation pathway (Hong et al., 2009).
T9749 18352-18409 Sentence denotes Serum factors can be utilized for blocking cancer growth.
T9748 18234-18351 Sentence denotes Indeed, specific inhibition of MEK by selumetinib enhances TMZ-induced cancer cell death in vivo (Holt et al., 2012).
T9747 18066-18233 Sentence denotes Preliminary studies from our screening of chemicals have selected certain small molecules that induce apoptosis of many types of cancer cells (Lu et al., unpublished).
T9746 17959-18065 Sentence denotes Thus, appropriate chemicals, which break apart the WWOX/MEK complex, are expected to cause GBM cell death.
T9745 17843-17958 Sentence denotes WWOX binds MEK, and that PMA dissociates this complex for causing apoptosis of T leukemia cells (Lin et al., 2011).
T9744 17741-17842 Sentence denotes Binding proteins for WWOX and/or p53 are likely to affect apoptosis and TMZ sensitivity in GBM cells.
T9743 17677-17740 Sentence denotes Whether WWOX affects TMZ sensitivity has never been determined.
T8408 17463-17559 Sentence denotes Mutant p53 proteins cannot bind ectopic WWOX in GBM cells, and WWOX is able to induce apoptosis.
T8407 17271-17462 Sentence denotes We postulate that in GBM cells, both wild type p53 and ectopic WWOX proteins appear to have a functional antagonism, thereby nullifying each other’s function in inducing apoptosis (Figure 2).
T8406 17170-17270 Sentence denotes Despite the presence of Ser46 in Δ40p53, binding of this protein with WWOX remains to be determined.
T8405 17120-17169 Sentence denotes UV irradiation enhances the binding interactions.
T8404 17035-17119 Sentence denotes Activated WWOX binds wild type p53 with Ser46 phosphorylation (Chang et al., 2005b).
T8403 16837-17034 Sentence denotes While the underlying mechanisms are unknown, it is reasonable to assume that the survival of human glioblastoma cells depends upon interactions between the gain-of-function of p53 mutants and WWOX.
T8402 16697-16836 Sentence denotes Unlike TMZ, WWOX induces apoptosis of U373-MG cells via a mitochondria-independent and caspase-3-independent pathway (Chiang et al., 2012).
T8401 16623-16696 Sentence denotes However, ectopic WWOX has no effect with U87-MG expressing wild type p53.
T8400 16437-16622 Sentence denotes Recently, we demonstrated that overexpressed WWOX induces apoptosis of glioblastoma U373-MG cells harboring mutant p53 by causing hypoploidy and DNA fragmentation (Chiang et al., 2012).
T8399 16274-16436 Sentence denotes Altered WWOX expression is shown in GBMs, in which downregulation of WWOX is associated with loss of heterozygosity and promoter methylation (Kosla et al., 2011).
T8398 16064-16273 Sentence denotes Loss of functional p53 confers sensitivity to TMZ in glioma cells, whereas wild type p53 increases the TMZ resistance (Blough et al., 2011). p53 mutants reduce TMZ sensitivity in gliomas (Blough et al., 2011).
T8397 15852-16063 Sentence denotes p53 mutants are considered as unfavorable factors for the effectiveness in radiotherapy and TMZ treatment in glioma cells (Gjerset et al., 1995; Hirose et al., 2001; Squatrito et al., 2010; Blough et al., 2011).
T8409 17560-17662 Sentence denotes Whether WWOX causes apoptosis in GBM expressing p53 isoforms is unknown and remains to be established.
T7495 15678-15817 Sentence denotes Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional activity on p21 and Bax promoters, as well as apoptosis.
T7494 15397-15677 Sentence denotes Co-transfection of p53 and p53β increases p53-mediated apoptosis, whereas co-expression of p53 with Δ133p53 suppresses p53-mediated apoptosis (Bourdon et al., 2005). Δ133p53 differentially regulates gene expression in p53-dependent and -independent manners (Aoubala et al., 2011).
T7493 15161-15396 Sentence denotes Full-length p53, Δ133p53, and p53β are localized mainly in the nucleus, and only few of them are in cytoplasm. p53γ and Δ133p53β are localized in the nucleus and cytoplasm. Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005).
T7492 15056-15160 Sentence denotes In cancers, aberrant expression of p53 isoforms occurs frequently (Bourdon et al., 2005; Bourdon, 2007).
T7491 14848-15055 Sentence denotes At least nine isoforms of p53 have been identified due to alternative mRNA splicing, multiple gene promoters, and alternative initiation sites of translation (Ghosh et al., 2004; Ray et al., 2006; Figure 2).
T6775 13520-13709 Sentence denotes Also, p53 plays a role in controlling cell motility via regulating the expression of smooth muscle α-actin (Comer et al., 1998), collagens IIα1 and VIα1 (Sun et al., 1999), and many others.
T6774 12990-13519 Sentence denotes The primary structures of p53 and its isoforms are depicted (Figure 2). p53 induces cell cycle arrest by transactivating genes such as cyclin-dependent kinase inhibitor p21, or microRNA miR34. p53 induces apoptosis by transactivating proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS, and inhibiting the antiapoptotic gene BCL-2 (Lane and Levine, 2010). p53 triggers pro-survival or cell death response, depending upon cell types, the intensity of the stress signal, and the extent of cellular damage (Menendez et al., 2009).
T6773 12874-12989 Sentence denotes Activated p53 mediates apoptosis, cell cycle arrest, senescence, DNA repair, or metabolism (Lane and Levine, 2010).
T3848 12638-12854 Sentence denotes Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).
T3847 12479-12637 Sentence denotes A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006).
T3846 12308-12478 Sentence denotes Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009).
T3845 12138-12307 Sentence denotes Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a).
T3844 12034-12137 Sentence denotes Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012).
T3843 11855-12033 Sentence denotes Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft.
T3842 11802-11854 Sentence denotes WWOX binds MEK in Jurkat T cells (Lin et al., 2011).
T3841 11532-11801 Sentence denotes Upon exposure to chemicals or environmental stress, such as UV irradiation and chemotherapeutic drugs, WWOX undergoes phosphorylation in Tyr33 and probably others sites, followed by relocating to mitochondria or nuclei for inducing apoptosis (Chang et al., 2007, 2010).
T3840 11475-11531 Sentence denotes Also, WWOX mediates cell death synergistically with p53.
T3839 11303-11474 Sentence denotes WWOX enhances the cytotoxic function of tumor necrosis factor by down-regulating apoptosis inhibitor Bcl-2 and Bcl-xL and up-regulating apoptotic p53 (Chang et al., 2001).
T3838 11096-11302 Sentence denotes Overexpressed WWOX induces apoptosis and inhibits proliferation of human hepatic carcinoma cells (Hu et al., 2012) and many cancer cell types (Chang et al., 2007, 2010; Salah et al., 2012; Su et al., 2012).
T3837 10917-11095 Sentence denotes No PPxY motif is in Dvl. Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009).
T3836 10801-10916 Sentence denotes Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1).
T3835 10648-10800 Sentence denotes Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b).
T3834 10475-10647 Sentence denotes Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010).
T3833 10385-10474 Sentence denotes No blocking of translocation of transcription factors to the nuclei by Wwox was observed.
T3832 10213-10384 Sentence denotes In stark contrast, Wwox co-migrates with proapoptotic and pro-survival transcription factors to the nuclei of neurons upon sciatic nerve axotomy in rats (Li et al., 2009).
T3831 10028-10212 Sentence denotes Transiently overexpressed WWOX binds transcription factors AP-2, p73, and c-Jun and block their nuclear relocation in vitro, which suppresses cancer cell survival (Salah et al., 2012).
T3830 9805-10027 Sentence denotes The first WW domain of WWOX may interact with proteins possessing a PPxY motif(s) such as AP-2γ, p73, ErbB4, Ezrin, SIMPLE, c-Jun, RUNX4, and many others (Chang et al., 2007; Salah et al., 2012; Su et al., 2012; Figure 1).
T3829 9638-9804 Sentence denotes Restoration of WWOX gene prevents the growth of lung cancer (Fabbri et al., 2005), pancreatic cancer (Nakayama et al., 2008), and prostate cancer (Hong et al., 2009).
T3828 9220-9637 Sentence denotes Expression of WWOX is either altered or lost from epigenetic modification in multiple malignant cancers, such as non-small cell lung carcinoma (Donati et al., 2007), hematopoietic malignancies (Ishii and Furukawa, 2004), gastric carcinoma (Aqeilan et al., 2004), pancreatic carcinoma (Kuroki et al., 2004), breast carcinoma (Guler et al., 2004; Aqeilan et al., 2007), and glioblastoma multiforme (Kosla et al., 2011).
T3827 7300-7500 Sentence denotes WWOX may act as an alternative receptor for sex steroid hormones, since its SDR domain possesses an NSYK motif capable of interacting with androgen and estrogen (Chang et al., 2005a; Su et al., 2012).
T3826 7008-7299 Sentence denotes The full-length WWOX protein is composed of two N-terminal WW domains, a C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domain, and a proapoptotic C-terminal tail D3 (Chang et al., 2001, 2007, 2010; Aqeilan et al., 2004, 2007; Hong et al., 2007; Salah et al., 2012) (Figure 1).
T3825 6910-7007 Sentence denotes This gene is located in chromosome 16q23.3–24.1, an area known as the common fragile site FRA16D.
T3824 6799-6909 Sentence denotes WW domain-containing oxidoreductase, known as WWOX, FOR, or WOX1, is encoded by human or mouse WWOX/Wwox gene.
T3823 6676-6798 Sentence denotes Recently, tumor suppressors p53 and WWOX were shown to regulate the apoptosis of glioblastoma cells (Chiang et al., 2012).
T909 6503-6633 Sentence denotes However, the role of CD133 as a marker for glioma cancer stem cells relative to its biological function has yet to be established.
T908 6376-6502 Sentence denotes CD133-positive cancer stem cells are expressed in both normal stem cells and cancer stem cells (Donovan and Pilkington, 2012).
T907 6187-6375 Sentence denotes The concept of cancer stem cell survival from treatment with TMZ and other chemotherapeutic drugs has been more complicated than previously thought (Beier et al., 2011; Chen et al., 2012).
T906 6119-6186 Sentence denotes Cancer stem cells are probably the key to failure in TMZ treatment.
T905 6031-6118 Sentence denotes Induced hyperoxia can be utilized to reverse TMZ resistance in GBMs (Sun et al., 2012).
T904 5930-6030 Sentence denotes Intratumoral hypoxia is common in GBMs and may be associated with the development of TMZ resistance.
T903 5818-5929 Sentence denotes STAT3 inhibitor or STAT3 knockdown potentiates TMZ efficacy in resistant GBM cell lines (Kohsaka et al., 2012).
T902 5704-5817 Sentence denotes Resveratrol, a natural polyphenol, reverses TMZ resistance via an NF-κB-dependent mechanism (Huang et al., 2012).
T901 5519-5703 Sentence denotes Interferon-β (IFN-β), levetiracetam (LEV), resveratrol, and valproic acid (VAP) increase the sensitivity of TMZ through MGMT-dependent or -independent mechanisms (Nakada et al., 2012).
T900 5359-5518 Sentence denotes Dual targeting of base excision repair and NAD(+) biosynthesis may reverse TMZ resistance in patients with resistant and recurrent GBM (Goellner et al., 2011).
T899 5153-5358 Sentence denotes Methoxyamine-blocker of base excision repair contributes significantly to TMZ cytotoxicity particularly when O6-methylguanine adducts are repaired or tolerated (Goellner et al., 2011; Zhang et al., 2012b).
T898 5001-5152 Sentence denotes Reversal of TMZ resistance may be achieved by MGMT pseudosubstrates, O6-benzylguanine and lomeguatrib to sensitize tumors to TMZ (Zhang et al., 2012b).
T897 4779-5000 Sentence denotes Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011).
T896 4568-4778 Sentence denotes The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012).
T895 4264-4567 Sentence denotes Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors.
T894 4177-4263 Sentence denotes MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012).
T893 4030-4176 Sentence denotes Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010).
T892 3911-4029 Sentence denotes An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival.
T891 3751-3910 Sentence denotes Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012).
T890 3673-3750 Sentence denotes The initiation of apoptotic signaling fails in the absence of the MMR system.
T889 3501-3672 Sentence denotes High expression of MGMT or loss of MMR contributes significantly to TMZ resistance in many clinical cases (Pollack et al., 2006; Hegi et al., 2008; Sarkaria et al., 2008).
T888 3252-3500 Sentence denotes Without MGMT repair, O6-methylguanine initiates activation of mismatch repair-deficient (MMR) proteins or Rad3-related protein kinase that ultimately leads to apoptotic cell death (Caporali et al., 2004; Wang and Edelmann, 2006; Roos et al., 2007).
T887 3054-3251 Sentence denotes The O6-methylguanine lesion is a substrate for direct repair by O6-methylguanine-DNA methyltransferase (MGMT) (Pollack et al., 2006; Hegi et al., 2008; Fukushima et al., 2009; Zhang et al., 2012b).
T886 2989-3053 Sentence denotes It is not determined whether this gene is involved in autophagy.
T885 2946-2988 Sentence denotes MAPO2 gene encodes a novel 37-kDa protein.
T884 2831-2945 Sentence denotes Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012).
T883 2675-2830 Sentence denotes However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013).
T882 2508-2674 Sentence denotes Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010).
T881 2382-2507 Sentence denotes The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003).
T880 2221-2381 Sentence denotes Temozolomide induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b).
T879 1830-2220 Sentence denotes Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b).
T878 1623-1829 Sentence denotes The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010).
T877 1469-1622 Sentence denotes High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012).
T876 1277-1468 Sentence denotes Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009).
T875 1137-1276 Sentence denotes Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012).
T82 374-530 Sentence denotes Loss of WWOX gene expression is frequently seen in malignant cancer cells due to promoter hypermethylation, genetic alterations, and translational blockade.
T81 252-373 Sentence denotes WW domain-containing oxidoreductase WWOX (FOR or WOX1) is a proapoptotic protein and is considered as a tumor suppressor.
T80 89-251 Sentence denotes Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide (TMZ) and therapeutic drugs.
T86 918-1077 Sentence denotes We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.
T85 727-917 Sentence denotes Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX.
T84 665-726 Sentence denotes WWOX is known to physically bind and stabilize wild type p53.
T83 531-664 Sentence denotes Intriguingly, ectopic expression of wild type WWOX preferentially induces apoptosis in human glioblastoma cells harboring mutant p53.
T1 0-78 Sentence denotes Tumor Suppressor WWOX and p53 Alterations and Drug Resistance in Glioblastomas
T2 80-88 Sentence denotes Abstract
T3 89-251 Sentence denotes Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide (TMZ) and therapeutic drugs.
T4 252-373 Sentence denotes WW domain-containing oxidoreductase WWOX (FOR or WOX1) is a proapoptotic protein and is considered as a tumor suppressor.
T5 374-530 Sentence denotes Loss of WWOX gene expression is frequently seen in malignant cancer cells due to promoter hypermethylation, genetic alterations, and translational blockade.
T6 531-664 Sentence denotes Intriguingly, ectopic expression of wild type WWOX preferentially induces apoptosis in human glioblastoma cells harboring mutant p53.
T7 665-726 Sentence denotes WWOX is known to physically bind and stabilize wild type p53.
T8 727-917 Sentence denotes Here, we provide an overview for the updated knowledge in p53 and WWOX, and postulate potential scenarios that wild type and mutant p53, or isoforms, modulate the apoptotic function of WWOX.
T9 918-1077 Sentence denotes We propose that triggering WWOX activation by therapeutic drugs under p53 functional deficiency is needed to overcome TMZ resistance and induce GBM cell death.
T10 1079-1136 Sentence denotes Mechanisms of Resistance to Temozolomide in Glioblastomas
T11 1137-1276 Sentence denotes Glioblastoma multiforme afflicts 12,500 new patients in the U.S. annually (Friedman et al., 2000; Stupp et al., 2009; Silber et al., 2012).
T12 1277-1468 Sentence denotes Glioblastoma (GBM) is highly lethal, and the average survival expectancy is 14.6 months, and the overall 5-year survival rate for GBM is only 9.8% (Friedman et al., 2000; Stupp et al., 2009).
T13 1469-1622 Sentence denotes High levels of resistance to current therapeutic modalities and cancer relapse are frequently seen in patients (Haar et al., 2012; Happold et al., 2012).
T14 1623-1829 Sentence denotes The current standard therapy for GBM mainly includes maximum debulking surgery, radiation, and treatment with the monofunctional alkylating agent temozolomide (TMZ) (Friedman et al., 2000; Nishikawa, 2010).
T15 1830-2220 Sentence denotes Multiple mechanisms are involved in the TMZ resistance, which may include cancer stem cells, microRNAs, drug efflux, DNA damage repair, tumor cells under hypoxia, histone deacetylation, epithelial-mesenchymal transition, STAT3 kinase, and many others (Haar et al., 2012; Happold et al., 2012; Johannessen and Bjerkvig, 2012; Kitange et al., 2012; Kohsaka et al., 2012; Zhang et al., 2012b).
T16 2221-2381 Sentence denotes Temozolomide induces generation of DNA lesions, including O6-methylguanine, N3-methyladenine, and N7-methylguanine (Goellner et al., 2011; Zhang et al., 2012b).
T17 2382-2507 Sentence denotes The O6-methylguanine lesion is known to trigger autophagy, rather than apoptosis, to cause cell death (Kanzawa et al., 2003).
T18 2508-2674 Sentence denotes Also, inhibition of antiapoptotic Bcl-2 by a pan-Bcl-2 inhibitor (−)-gossypol leads to autophagic death in gliomas and enhances the action of TMZ (Voss et al., 2010).
T19 2675-2830 Sentence denotes However, a recent study demonstrated that TMZ-induced autophagy is pro-survival, and may block the eventual apoptosis in GBM cells (Knizhnik et al., 2013).
T20 2831-2945 Sentence denotes Also, MAPO2 (C1orf201) gene participates in the O6-methylguanine lesion-induced apoptosis (Fujikane et al., 2012).
T21 2946-2988 Sentence denotes MAPO2 gene encodes a novel 37-kDa protein.
T22 2989-3053 Sentence denotes It is not determined whether this gene is involved in autophagy.
T23 3054-3251 Sentence denotes The O6-methylguanine lesion is a substrate for direct repair by O6-methylguanine-DNA methyltransferase (MGMT) (Pollack et al., 2006; Hegi et al., 2008; Fukushima et al., 2009; Zhang et al., 2012b).
T24 3252-3500 Sentence denotes Without MGMT repair, O6-methylguanine initiates activation of mismatch repair-deficient (MMR) proteins or Rad3-related protein kinase that ultimately leads to apoptotic cell death (Caporali et al., 2004; Wang and Edelmann, 2006; Roos et al., 2007).
T25 3501-3672 Sentence denotes High expression of MGMT or loss of MMR contributes significantly to TMZ resistance in many clinical cases (Pollack et al., 2006; Hegi et al., 2008; Sarkaria et al., 2008).
T26 3673-3750 Sentence denotes The initiation of apoptotic signaling fails in the absence of the MMR system.
T27 3751-3910 Sentence denotes Sensitivity to TMZ is significantly associated with the methylation status of MGMT gene promoter in cells committed to differentiation (Villalva et al., 2012).
T28 3911-4029 Sentence denotes An increase in MGMT gene promoter methylation, which blocks MGMT protein expression, prolongs cancer patient survival.
T29 4030-4176 Sentence denotes Intriguingly, overexpressed microRNA-21 reduces Bax/Bcl-2 ratio and caspase-3 activity, thereby blocking TMZ-induced apoptosis (Shi et al., 2010).
T30 4177-4263 Sentence denotes MicroRNA-21 is considered as a pro-survival factor for cancer cells (Li et al., 2012).
T31 4264-4567 Sentence denotes Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. α5β1 integrin negatively regulates p53 signaling, and the event induces glioma cell resistance to TMZ (Janouskova et al., 2012). α5β1 integrin is considered as a therapeutic target for high-grade brain tumors.
T32 4568-4778 Sentence denotes The base excision repair enzyme alkylpurine-DNA-N-glycosylase (APNG), which repairs the cytotoxic lesions N3-methyladenine and N7-methylguanine, also participates in the TMZ resistance (Agnihotri et al., 2012).
T33 4779-5000 Sentence denotes Upregulation of mitochondrial respiratory chain coupling to suppress the production of reactive oxygen species (ROS) regulated by cytochrome c oxidase contributes in part to TMZ resistance in gliomas (Oliva et al., 2011).
T34 5001-5152 Sentence denotes Reversal of TMZ resistance may be achieved by MGMT pseudosubstrates, O6-benzylguanine and lomeguatrib to sensitize tumors to TMZ (Zhang et al., 2012b).
T35 5153-5358 Sentence denotes Methoxyamine-blocker of base excision repair contributes significantly to TMZ cytotoxicity particularly when O6-methylguanine adducts are repaired or tolerated (Goellner et al., 2011; Zhang et al., 2012b).
T36 5359-5518 Sentence denotes Dual targeting of base excision repair and NAD(+) biosynthesis may reverse TMZ resistance in patients with resistant and recurrent GBM (Goellner et al., 2011).
T37 5519-5703 Sentence denotes Interferon-β (IFN-β), levetiracetam (LEV), resveratrol, and valproic acid (VAP) increase the sensitivity of TMZ through MGMT-dependent or -independent mechanisms (Nakada et al., 2012).
T38 5704-5817 Sentence denotes Resveratrol, a natural polyphenol, reverses TMZ resistance via an NF-κB-dependent mechanism (Huang et al., 2012).
T39 5818-5929 Sentence denotes STAT3 inhibitor or STAT3 knockdown potentiates TMZ efficacy in resistant GBM cell lines (Kohsaka et al., 2012).
T40 5930-6030 Sentence denotes Intratumoral hypoxia is common in GBMs and may be associated with the development of TMZ resistance.
T41 6031-6118 Sentence denotes Induced hyperoxia can be utilized to reverse TMZ resistance in GBMs (Sun et al., 2012).
T42 6119-6186 Sentence denotes Cancer stem cells are probably the key to failure in TMZ treatment.
T43 6187-6375 Sentence denotes The concept of cancer stem cell survival from treatment with TMZ and other chemotherapeutic drugs has been more complicated than previously thought (Beier et al., 2011; Chen et al., 2012).
T44 6376-6502 Sentence denotes CD133-positive cancer stem cells are expressed in both normal stem cells and cancer stem cells (Donovan and Pilkington, 2012).
T45 6503-6633 Sentence denotes However, the role of CD133 as a marker for glioma cancer stem cells relative to its biological function has yet to be established.
T46 6635-6675 Sentence denotes WW Domain-Containing Oxidoreductase WWOX
T47 6676-6798 Sentence denotes Recently, tumor suppressors p53 and WWOX were shown to regulate the apoptosis of glioblastoma cells (Chiang et al., 2012).
T48 6799-6909 Sentence denotes WW domain-containing oxidoreductase, known as WWOX, FOR, or WOX1, is encoded by human or mouse WWOX/Wwox gene.
T49 6910-7007 Sentence denotes This gene is located in chromosome 16q23.3–24.1, an area known as the common fragile site FRA16D.
T50 7008-7299 Sentence denotes The full-length WWOX protein is composed of two N-terminal WW domains, a C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domain, and a proapoptotic C-terminal tail D3 (Chang et al., 2001, 2007, 2010; Aqeilan et al., 2004, 2007; Hong et al., 2007; Salah et al., 2012) (Figure 1).
T51 7300-7500 Sentence denotes WWOX may act as an alternative receptor for sex steroid hormones, since its SDR domain possesses an NSYK motif capable of interacting with androgen and estrogen (Chang et al., 2005a; Su et al., 2012).
T52 7501-7574 Sentence denotes Figure 1 Schematic diagrams of WWOX structure and its role in signaling.
T53 7575-7703 Sentence denotes WWOX contains two N-terminal WW domains, a C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domain, and a D3 region.
T54 7704-7865 Sentence denotes A nuclear localization signal (NLS) is in between the WW domains (Chang et al., 2003, 2007; Del Mare et al., 2011; Salah et al., 2012; Su et al., 2012; reviews).
T55 7866-7921 Sentence denotes The SDR domain possesses a mitochondria-binding region.
T56 7922-7995 Sentence denotes There are two conserved tyrosine phosphorylation sites, Tyr33 and Tyr287.
T57 7996-8120 Sentence denotes Other phosphorylation sites predicted by NetPhos 2.0 Server are Tyr6, Thr12, Ser14, Tyr61, Tyr293, and Thr3B3, respectively.
T58 8121-8192 Sentence denotes Upon stress stimulation, WWOX is phosphorylated in Tyr33 and binds p53.
T59 8193-8279 Sentence denotes The WWOX/p53 complex then translocates to mitochondria or nucleus to induce apoptosis.
T60 8280-8488 Sentence denotes WWOX also binds PPxY motif-containing transcription factors, such as RUNX2, c-Jun, and ERBB4, via its first WW domain, and the binding blocks the activity of these proteins by retaining them in the cytoplasm.
T61 8489-8523 Sentence denotes WWOX binds Tau via its SDR domain.
T62 8524-8627 Sentence denotes WWOX participates in the Wnt/β-catenin signal pathway by binding Dvl and inhibiting its nuclear import.
T63 8628-8786 Sentence denotes Phorbol ester stimulates the dissociation of MEK/WWOX complex in Jurkat T cell, and the released WWOX translocates to the mitochondria for causing cell death.
T64 8787-8871 Sentence denotes WWOX is recruited to the membrane area by association with Hyal-2 and phospho-Ezrin.
T65 8872-8917 Sentence denotes Hyal-2 is an alternative receptor for TGF-β1.
T66 8918-9066 Sentence denotes In response to TGF-β1, WWOX binds Hyal-2 and forms a complex, followed by relocating to the nucleus and enhancing the SMAD-driven promoter activity.
T67 9067-9219 Sentence denotes Ack1, activated Cdc42-associated kinase 1; Hyal-2, hyaluronoglucosaminidase 2; CKI, casein kinase; GSK, glycogen synthase kinase; PKA, protein kinase A.
T68 9220-9637 Sentence denotes Expression of WWOX is either altered or lost from epigenetic modification in multiple malignant cancers, such as non-small cell lung carcinoma (Donati et al., 2007), hematopoietic malignancies (Ishii and Furukawa, 2004), gastric carcinoma (Aqeilan et al., 2004), pancreatic carcinoma (Kuroki et al., 2004), breast carcinoma (Guler et al., 2004; Aqeilan et al., 2007), and glioblastoma multiforme (Kosla et al., 2011).
T69 9638-9804 Sentence denotes Restoration of WWOX gene prevents the growth of lung cancer (Fabbri et al., 2005), pancreatic cancer (Nakayama et al., 2008), and prostate cancer (Hong et al., 2009).
T70 9805-10027 Sentence denotes The first WW domain of WWOX may interact with proteins possessing a PPxY motif(s) such as AP-2γ, p73, ErbB4, Ezrin, SIMPLE, c-Jun, RUNX4, and many others (Chang et al., 2007; Salah et al., 2012; Su et al., 2012; Figure 1).
T71 10028-10212 Sentence denotes Transiently overexpressed WWOX binds transcription factors AP-2, p73, and c-Jun and block their nuclear relocation in vitro, which suppresses cancer cell survival (Salah et al., 2012).
T72 10213-10384 Sentence denotes In stark contrast, Wwox co-migrates with proapoptotic and pro-survival transcription factors to the nuclei of neurons upon sciatic nerve axotomy in rats (Li et al., 2009).
T73 10385-10474 Sentence denotes No blocking of translocation of transcription factors to the nuclei by Wwox was observed.
T74 10475-10647 Sentence denotes Under stress conditions, WWOX is activated via phosphorylation at Tyr33, and binds proteins independently of the PPxY motif (Chang et al., 2001, 2003, 2005a,b, 2007, 2010).
T75 10648-10800 Sentence denotes Activated WWOX physically interacts with serine 46-phosphorylated p53 (Figure 1), which stabilizes p53 and its apoptotic function (Chang et al., 2005b).
T76 10801-10916 Sentence denotes Also, WWOX binds Disheveled proteins (Dvl), which are key components in Wnt/β-catenin signaling pathway (Figure 1).
T77 10917-10941 Sentence denotes No PPxY motif is in Dvl.
T78 10942-11095 Sentence denotes Transiently overexpressed WWOX sequesters Dvl-2 in the cytoplasm and thereby blocks Dvl-2-mediated TCF transcriptional activity (Bouteille et al., 2009).
T79 11096-11302 Sentence denotes Overexpressed WWOX induces apoptosis and inhibits proliferation of human hepatic carcinoma cells (Hu et al., 2012) and many cancer cell types (Chang et al., 2007, 2010; Salah et al., 2012; Su et al., 2012).
T80 11303-11474 Sentence denotes WWOX enhances the cytotoxic function of tumor necrosis factor by down-regulating apoptosis inhibitor Bcl-2 and Bcl-xL and up-regulating apoptotic p53 (Chang et al., 2001).
T81 11475-11531 Sentence denotes Also, WWOX mediates cell death synergistically with p53.
T82 11532-11801 Sentence denotes Upon exposure to chemicals or environmental stress, such as UV irradiation and chemotherapeutic drugs, WWOX undergoes phosphorylation in Tyr33 and probably others sites, followed by relocating to mitochondria or nuclei for inducing apoptosis (Chang et al., 2007, 2010).
T83 11802-11854 Sentence denotes WWOX binds MEK in Jurkat T cells (Lin et al., 2011).
T84 11855-12033 Sentence denotes Phorbol myristate acetate (PMA) dissociates the MEK/WWOX complex and induces WWOX to translocate to the mitochondria to induce apoptosis, whereas MEK relocates to the lipid raft.
T85 12034-12137 Sentence denotes Inhibition of MEK activity increases TMZ-induced suppression of cancer cell growth (Holt et al., 2012).
T86 12138-12307 Sentence denotes Ectopic expression of WWOX in A549 cells induces procaspase-3 and procaspase-9 activation and induces cytochrome C releasing from the mitochondria (Zhang et al., 2012a).
T87 12308-12478 Sentence denotes Complement C1q induces ectopic WWOX phosphorylation in Try33 and leads to cell apoptosis independently of the classical complement activation pathway (Hong et al., 2009).
T88 12479-12637 Sentence denotes A portion of WWOX is anchored in the membrane/cytoskeleton area via binding with hyaluronidase Hyal-2 (Hsu et al., 2009) and Phospho-Ezrin (Jin et al., 2006).
T89 12638-12854 Sentence denotes Transforming growth factor β1 binds Hyal-2 as a cognate receptor to signal the formation of the WWOX/Hyal-2/Smad4 complex to relocate to the nucleus for enhancing the SMAD-driven promoter activity (Hsu et al., 2009).
T90 12856-12873 Sentence denotes p53 and Functions
T91 12874-12989 Sentence denotes Activated p53 mediates apoptosis, cell cycle arrest, senescence, DNA repair, or metabolism (Lane and Levine, 2010).
T92 12990-13519 Sentence denotes The primary structures of p53 and its isoforms are depicted (Figure 2). p53 induces cell cycle arrest by transactivating genes such as cyclin-dependent kinase inhibitor p21, or microRNA miR34. p53 induces apoptosis by transactivating proapoptotic genes such as BAX, PUMA, SCOTIN, and FAS, and inhibiting the antiapoptotic gene BCL-2 (Lane and Levine, 2010). p53 triggers pro-survival or cell death response, depending upon cell types, the intensity of the stress signal, and the extent of cellular damage (Menendez et al., 2009).
T93 13520-13709 Sentence denotes Also, p53 plays a role in controlling cell motility via regulating the expression of smooth muscle α-actin (Comer et al., 1998), collagens IIα1 and VIα1 (Sun et al., 1999), and many others.
T94 13710-13999 Sentence denotes Figure 2 p53 and WWOX in GBM cell apoptosis. (A) Full-length p53 possesses two N-terminal transactivation acidic domains, a proline-rich domain, a central DNA-binding region, and a C-terminal domain, containing a nuclear localization signal, an oligomerization domain, and a basic region.
T95 14000-14135 Sentence denotes N-terminal deletion mutants of p53 are also shown. (B) Three likely scenarios are proposed for WWOX and p53 to regulate GBM cell death.
T96 14136-14231 Sentence denotes First, ectopic WWOX fails to induce apoptosis of GBM cells expressing endogenous wild type p53.
T97 14232-14371 Sentence denotes It appears that ectopic WWOX binds and functionally antagonizes p53, and both proteins nullify each other’s function in inducing apoptosis.
T98 14372-14468 Sentence denotes Second, no physical interactions between mutant p53 proteins and WWOX are expected in GBM cells.
T99 14469-14536 Sentence denotes Thus, ectopic WWOX induce apoptosis in mutant p53-expressing cells.
T100 14537-14589 Sentence denotes Finally, whether WWOX binds p53 isoforms is unknown.
T101 14590-14703 Sentence denotes Also, whether ectopic WWOX induction of apoptosis in GBM cells expressing p53 isoforms remains to be established.
T102 14704-14833 Sentence denotes TAD, transactivation domain; PrD, proline domain; NLS, nuclear localization signal; OD, oligomerization domain; BR, basic region.
T103 14835-14847 Sentence denotes p53 Isoforms
T104 14848-15055 Sentence denotes At least nine isoforms of p53 have been identified due to alternative mRNA splicing, multiple gene promoters, and alternative initiation sites of translation (Ghosh et al., 2004; Ray et al., 2006; Figure 2).
T105 15056-15160 Sentence denotes In cancers, aberrant expression of p53 isoforms occurs frequently (Bourdon et al., 2005; Bourdon, 2007).
T106 15161-15396 Sentence denotes Full-length p53, Δ133p53, and p53β are localized mainly in the nucleus, and only few of them are in cytoplasm. p53γ and Δ133p53β are localized in the nucleus and cytoplasm. Δ133p53γ is localized in the cytoplasm (Bourdon et al., 2005).
T107 15397-15677 Sentence denotes Co-transfection of p53 and p53β increases p53-mediated apoptosis, whereas co-expression of p53 with Δ133p53 suppresses p53-mediated apoptosis (Bourdon et al., 2005). Δ133p53 differentially regulates gene expression in p53-dependent and -independent manners (Aoubala et al., 2011).
T108 15678-15817 Sentence denotes Co-expression of Δ133p53β or Δ133p53γ with p53 does not affect p53 transcriptional activity on p21 and Bax promoters, as well as apoptosis.
T109 15819-15851 Sentence denotes p53 and WWOX Alterations in GBMs
T110 15852-16063 Sentence denotes p53 mutants are considered as unfavorable factors for the effectiveness in radiotherapy and TMZ treatment in glioma cells (Gjerset et al., 1995; Hirose et al., 2001; Squatrito et al., 2010; Blough et al., 2011).
T111 16064-16273 Sentence denotes Loss of functional p53 confers sensitivity to TMZ in glioma cells, whereas wild type p53 increases the TMZ resistance (Blough et al., 2011). p53 mutants reduce TMZ sensitivity in gliomas (Blough et al., 2011).
T112 16274-16436 Sentence denotes Altered WWOX expression is shown in GBMs, in which downregulation of WWOX is associated with loss of heterozygosity and promoter methylation (Kosla et al., 2011).
T113 16437-16622 Sentence denotes Recently, we demonstrated that overexpressed WWOX induces apoptosis of glioblastoma U373-MG cells harboring mutant p53 by causing hypoploidy and DNA fragmentation (Chiang et al., 2012).
T114 16623-16696 Sentence denotes However, ectopic WWOX has no effect with U87-MG expressing wild type p53.
T115 16697-16836 Sentence denotes Unlike TMZ, WWOX induces apoptosis of U373-MG cells via a mitochondria-independent and caspase-3-independent pathway (Chiang et al., 2012).
T116 16837-17034 Sentence denotes While the underlying mechanisms are unknown, it is reasonable to assume that the survival of human glioblastoma cells depends upon interactions between the gain-of-function of p53 mutants and WWOX.
T117 17035-17119 Sentence denotes Activated WWOX binds wild type p53 with Ser46 phosphorylation (Chang et al., 2005b).
T118 17120-17169 Sentence denotes UV irradiation enhances the binding interactions.
T119 17170-17270 Sentence denotes Despite the presence of Ser46 in Δ40p53, binding of this protein with WWOX remains to be determined.
T120 17271-17462 Sentence denotes We postulate that in GBM cells, both wild type p53 and ectopic WWOX proteins appear to have a functional antagonism, thereby nullifying each other’s function in inducing apoptosis (Figure 2).
T121 17463-17559 Sentence denotes Mutant p53 proteins cannot bind ectopic WWOX in GBM cells, and WWOX is able to induce apoptosis.
T122 17560-17662 Sentence denotes Whether WWOX causes apoptosis in GBM expressing p53 isoforms is unknown and remains to be established.
T123 17664-17676 Sentence denotes Perspectives
T124 17677-17740 Sentence denotes Whether WWOX affects TMZ sensitivity has never been determined.
T125 17741-17842 Sentence denotes Binding proteins for WWOX and/or p53 are likely to affect apoptosis and TMZ sensitivity in GBM cells.
T126 17843-17958 Sentence denotes WWOX binds MEK, and that PMA dissociates this complex for causing apoptosis of T leukemia cells (Lin et al., 2011).
T127 17959-18065 Sentence denotes Thus, appropriate chemicals, which break apart the WWOX/MEK complex, are expected to cause GBM cell death.
T128 18066-18233 Sentence denotes Preliminary studies from our screening of chemicals have selected certain small molecules that induce apoptosis of many types of cancer cells (Lu et al., unpublished).
T129 18234-18351 Sentence denotes Indeed, specific inhibition of MEK by selumetinib enhances TMZ-induced cancer cell death in vivo (Holt et al., 2012).
T130 18352-18409 Sentence denotes Serum factors can be utilized for blocking cancer growth.
T131 18410-18607 Sentence denotes For example, serum complement C1q induces apoptosis of prostate cancer and neuroblastomas cells without participation of downstream proteins in the classical activation pathway (Hong et al., 2009).
T132 18608-18672 Sentence denotes In this event, ectopic WWOX is activated for inducing apoptosis.
T133 18673-18793 Sentence denotes Failure of ectopic WWOX in inducing apoptosis of glioma cells possessing wild type p53 is unusual (Chiang et al., 2012).
T134 18794-18996 Sentence denotes In most cases, we have shown that p53 functionally interacts with WWOX, and both proteins induce apoptosis in a synergistic manner (Chang et al., 2001, 2003, 2005a,b, 2007, 2010, 2012; Su et al., 2012).
T135 18997-19130 Sentence denotes A likely scenario is that p53-binding proteins, which are present in GBMs, may interfere with the apoptotic function of WWOX and p53.
T136 19131-19221 Sentence denotes Functional antagonism among tumor suppressors has never been documented in the literature.
T137 19222-19464 Sentence denotes However, it is not surprising to find that many tumor suppressor proteins, e.g., p53, WWOX, Smad4, PTEN, PP2A, and etc., are significantly upregulated during the early stage of cancer progression (Lai et al., 2005; Chang et al., unpublished).
T138 19465-19562 Sentence denotes Do these proteins act synergistically in blocking cancer progression but lose control eventually?
T139 19563-19637 Sentence denotes Or, do they counteract each other’s function, thus allowing cancer growth?
T140 19638-19751 Sentence denotes Whether endogenous WWOX counteracts with the function of endogenous p53 is unknown and remains to be established.
T141 19752-19864 Sentence denotes One of the unique characteristics for malignant gliomas is their diffuse infiltration into distant brain tissue.
T142 19865-20028 Sentence denotes Signal pathways, involving PI3K, Akt, mTOR, NF-κB, and autophagy, are believed to confer these migrating cells resistant to apoptotic death (Lefranc et al., 2005).
T143 20029-20305 Sentence denotes Glioma cells possess CD44 as a receptor for interacting with brain matrix hyaluronan (Murai et al., 2004; Yoshida et al., 2012), and secrete hyaluronidases and metalloproteinases to facilitate their migration (Delpech et al., 2002; Junker et al., 2003; Hagemann et al., 2012).
T144 20306-20374 Sentence denotes Also, lack of WWOX expression is expected to enhance cell migration.
T145 20375-20510 Sentence denotes For example, loss of WWOX facilitates migration of ovarian cancer and osteosarcoma cells (Gourley et al., 2009; Del Mare et al., 2011).
T146 20511-20708 Sentence denotes Ectopic expression of TIAF1 (TGF-β-induced antiapoptotic factor), p53, and WWOX suppresses anchorage-independent growth and cell migration and causes apoptosis in cancer cells (Chang et al., 2012).
T147 20709-20817 Sentence denotes We believe that glioma cells, with stem cell-like properties, migrate individually rather than collectively.
T148 20818-20969 Sentence denotes This assumption is based upon our observations that mouse Wwox gene knockout cells (e.g., embryonic fibroblasts) migrate individually and aggressively.
T149 20970-21047 Sentence denotes In contrast, wild type cells migrate collectively (Chou et al., unpublished).
T150 21048-21286 Sentence denotes While a portion of WWOX is anchored on the cell membrane/cytoskeleton, WWOX-negative cells lose recognition by parental WWOX-positive cells, and this increases the mobility of WWOX-negative cells to move away from the WWOX-positive cells.
T151 21287-21424 Sentence denotes Conceivably, WWOX-negative glioma cells migrate individually and turn away from WWOX-expressing brain cells to low WWOX expression areas.
T152 21425-21580 Sentence denotes Apparently, the migratory behavior of WWOX-negative glioma cells may account for the diffuse invasion into distant brain tissue (Chou et al., unpublished).
T153 21581-21799 Sentence denotes Metabolic alterations have been shown in Wwox knockout mice, including postnatal lethality, bone metabolism defects, ataxia, steroidogenesis, and generation of osteosarcomas (Del Mare et al., 2011; Salah et al., 2012).
T154 21800-21959 Sentence denotes In a Drosophila model, Wwox is shown to participate in pathways involving aerobic metabolism and oxidative stress for generation of ROS (O’Keefe et al., 2011).
T155 21960-22046 Sentence denotes Under UV stress, functional Wwox gene expression induces ROS production in Drosophila.
T156 22047-22167 Sentence denotes Cancer cells are known to overly utilize glycolysis for growth advantage – the so-called Warburg (Moncada et al., 2012).
T157 22168-22317 Sentence denotes Conceivably, WWOX is likely to override glucose consumption in cancer cells and exerts generation of ROS to curb the cancer cell growth and invasion.
T158 22318-22472 Sentence denotes In summary, in this perspective article we have discussed the potential role of tumor suppressors p53 and WWOX in regulating TMZ sensitivity in GBM cells.
T159 22473-22641 Sentence denotes We have shown the role of WWOX in controlling cell migration and metabolic alterations, and discussed the effects of WWOX deficiency and TMZ resistance in cancer cells.
T160 22643-22663 Sentence denotes Authors Contribution
T161 22664-22945 Sentence denotes Ming-Fu Chiang and Chun-I Sze wrote the sections dealing with TMZ; Pei-Yi Chou wrote the review sections for p53 and WWOX and designed graphs; Wan-Jen Wang managed citations; Nan-Shan Chang conceived ideas, wrote and thoroughly revised the manuscript, and discussed with coauthors.
T162 22947-22977 Sentence denotes Conflict of Interest Statement
T163 22978-23150 Sentence denotes The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

ICD10

Id Subject Object Predicate Lexical cue
T9950 21698-21704 http://purl.bioontology.org/ontology/ICD10/R27.0 denotes ataxia

simple1

Id Subject Object Predicate Lexical cue
T148 17-21 Protein denotes WWOX
T149 26-29 Protein denotes p53
T14172 14664-14667 Protein denotes p53
T14171 14612-14616 Protein denotes WWOX
T14170 14565-14568 Protein denotes p53
T14169 14554-14558 Protein denotes WWOX
T14168 14515-14518 Protein denotes p53
T14167 14483-14487 Protein denotes WWOX
T14166 14437-14441 Protein denotes WWOX
T14165 14420-14423 Protein denotes p53
T14164 14296-14299 Protein denotes p53
T14163 14256-14260 Protein denotes WWOX
T14162 14227-14230 Protein denotes p53
T14161 14151-14155 Protein denotes WWOX
T14160 14104-14107 Protein denotes p53
T14159 14095-14099 Protein denotes WWOX
T14158 14031-14034 Protein denotes p53
T14157 13772-13775 Protein denotes p53
T14156 13728-13732 Protein denotes WWOX
T14155 13720-13723 Protein denotes p53
T13042 9118-9144 Protein denotes hyaluronoglucosaminidase 2
T13041 9110-9116 Protein denotes Hyal-2
T13040 9073-9108 Protein denotes activated Cdc42-associated kinase 1
T13039 9067-9071 Protein denotes Ack1
T13038 8952-8958 Protein denotes Hyal-2
T13037 8941-8945 Protein denotes WWOX
T13036 8933-8939 Protein denotes TGF-β1
T13035 8910-8916 Protein denotes TGF-β1
T13034 8872-8878 Protein denotes Hyal-2
T13033 8865-8870 Protein denotes Ezrin
T13032 8846-8852 Protein denotes Hyal-2
T13031 8787-8791 Protein denotes WWOX
T13030 8725-8729 Protein denotes WWOX
T13029 8524-8528 Protein denotes WWOX
T13028 8500-8503 Protein denotes Tau
T13027 8489-8493 Protein denotes WWOX
T13026 8367-8372 Protein denotes ERBB4
T13025 8356-8361 Protein denotes c-Jun
T13024 8349-8354 Protein denotes RUNX2
T13023 8280-8284 Protein denotes WWOX
T13022 8188-8191 Protein denotes p53
T13021 8146-8150 Protein denotes WWOX
T13020 7575-7579 Protein denotes WWOX
T13019 7533-7537 Protein denotes WWOX
T12471 22781-22785 Protein denotes WWOX
T12470 22773-22776 Protein denotes p53
T10068 22590-22594 Protein denotes WWOX
T10067 22499-22503 Protein denotes WWOX
T10066 22424-22428 Protein denotes WWOX
T10065 22416-22419 Protein denotes p53
T10064 22181-22185 Protein denotes WWOX
T10063 21988-21992 Protein denotes Wwox
T10062 21823-21827 Protein denotes Wwox
T10061 21622-21626 Protein denotes Wwox
T10060 21463-21467 Protein denotes WWOX
T10059 21402-21406 Protein denotes WWOX
T10058 21367-21371 Protein denotes WWOX
T10057 21300-21304 Protein denotes WWOX
T10056 21266-21270 Protein denotes WWOX
T10055 21224-21228 Protein denotes WWOX
T10054 21168-21172 Protein denotes WWOX
T10053 21119-21123 Protein denotes WWOX
T10052 21067-21071 Protein denotes WWOX
T10051 20876-20880 Protein denotes Wwox
T10050 20586-20590 Protein denotes WWOX
T10049 20577-20580 Protein denotes p53
T10048 20533-20538 Protein denotes TIAF1
T10047 20396-20400 Protein denotes WWOX
T10046 20320-20324 Protein denotes WWOX
T10045 20050-20054 Protein denotes CD44
T10044 19903-19907 Protein denotes mTOR
T10043 19898-19901 Protein denotes Akt
T10042 19706-19709 Protein denotes p53
T10041 19657-19661 Protein denotes WWOX
T10040 19321-19325 Protein denotes PTEN
T10039 19314-19319 Protein denotes Smad4
T10038 19308-19312 Protein denotes WWOX
T10037 19303-19306 Protein denotes p53
T10036 19126-19129 Protein denotes p53
T10035 19117-19121 Protein denotes WWOX
T10034 19023-19026 Protein denotes p53
T10033 18860-18864 Protein denotes WWOX
T10032 18828-18831 Protein denotes p53
T10031 18756-18759 Protein denotes p53
T10030 18692-18696 Protein denotes WWOX
T10029 18631-18635 Protein denotes WWOX
T10028 17843-17847 Protein denotes WWOX
T10027 17774-17777 Protein denotes p53
T10026 17762-17766 Protein denotes WWOX
T10025 17685-17689 Protein denotes WWOX
T8539 17608-17611 Protein denotes p53
T8538 17568-17572 Protein denotes WWOX
T8537 17526-17530 Protein denotes WWOX
T8536 17503-17507 Protein denotes WWOX
T8535 17470-17473 Protein denotes p53
T8534 17334-17338 Protein denotes WWOX
T8533 17318-17321 Protein denotes p53
T8532 17240-17244 Protein denotes WWOX
T8531 17203-17209 Protein denotes Δ40p53
T8530 17066-17069 Protein denotes p53
T8529 17045-17049 Protein denotes WWOX
T8528 17029-17033 Protein denotes WWOX
T8527 17013-17016 Protein denotes p53
T8526 16784-16793 Protein denotes caspase-3
T8525 16709-16713 Protein denotes WWOX
T8524 16692-16695 Protein denotes p53
T8523 16640-16644 Protein denotes WWOX
T8522 16552-16555 Protein denotes p53
T8521 16482-16486 Protein denotes WWOX
T8520 16343-16347 Protein denotes WWOX
T8519 16282-16286 Protein denotes WWOX
T8518 16205-16208 Protein denotes p53
T8517 16149-16152 Protein denotes p53
T8516 16083-16086 Protein denotes p53
T8515 15852-15855 Protein denotes p53
T7619 15781-15784 Protein denotes Bax
T7618 15773-15776 Protein denotes p21
T7617 15741-15744 Protein denotes p53
T7616 15721-15724 Protein denotes p53
T7615 15707-15715 Protein denotes Δ133p53γ
T7614 15695-15703 Protein denotes Δ133p53β
T7613 15615-15618 Protein denotes p53
T7612 15563-15570 Protein denotes Δ133p53
T7611 15516-15519 Protein denotes p53
T7610 15497-15504 Protein denotes Δ133p53
T7609 15488-15491 Protein denotes p53
T7608 15439-15442 Protein denotes p53
T7607 15424-15428 Protein denotes p53β
T7606 15416-15419 Protein denotes p53
T7605 15334-15342 Protein denotes Δ133p53γ
T7604 15281-15289 Protein denotes Δ133p53β
T7603 15272-15276 Protein denotes p53γ
T7602 15191-15195 Protein denotes p53β
T7601 15178-15185 Protein denotes Δ133p53
T7600 15173-15176 Protein denotes p53
T7599 15091-15094 Protein denotes p53
T7598 14874-14877 Protein denotes p53
T6866 13668-13672 Protein denotes VIα1
T6865 13649-13663 Protein denotes collagens IIα1
T6864 13605-13626 Protein denotes smooth muscle α-actin
T6863 13526-13529 Protein denotes p53
T6862 13348-13351 Protein denotes p53
T6861 13317-13322 Protein denotes BCL-2
T6860 13274-13277 Protein denotes FAS
T6859 13262-13268 Protein denotes SCOTIN
T6858 13256-13260 Protein denotes PUMA
T6857 13251-13254 Protein denotes BAX
T6856 13183-13186 Protein denotes p53
T6855 13176-13181 Protein denotes miR34
T6854 13159-13162 Protein denotes p21
T6853 13062-13065 Protein denotes p53
T6852 13016-13019 Protein denotes p53
T6851 12884-12887 Protein denotes p53
T4146 12674-12680 Protein denotes Hyal-2
T4145 12638-12667 Protein denotes Transforming growth factor β1
T4144 12612-12617 Protein denotes Ezrin
T4143 12574-12580 Protein denotes Hyal-2
T4142 12492-12496 Protein denotes WWOX
T4141 12339-12343 Protein denotes WWOX
T4140 12204-12216 Protein denotes procaspase-9
T4139 12187-12199 Protein denotes procaspase-3
T4138 12160-12164 Protein denotes WWOX
T4137 11932-11936 Protein denotes WWOX
T4136 11802-11806 Protein denotes WWOX
T4135 11635-11639 Protein denotes WWOX
T4134 11527-11530 Protein denotes p53
T4133 11481-11485 Protein denotes WWOX
T4132 11449-11452 Protein denotes p53
T4131 11414-11420 Protein denotes Bcl-xL
T4130 11404-11409 Protein denotes Bcl-2
T4129 11343-11364 Protein denotes tumor necrosis factor
T4128 11303-11307 Protein denotes WWOX
T4127 11110-11114 Protein denotes WWOX
T4126 11026-11031 Protein denotes Dvl-2
T4125 10984-10989 Protein denotes Dvl-2
T4124 10968-10972 Protein denotes WWOX
T4123 10877-10886 Protein denotes β-catenin
T4122 10807-10811 Protein denotes WWOX
T4121 10747-10750 Protein denotes p53
T4120 10714-10717 Protein denotes p53
T4119 10658-10662 Protein denotes WWOX
T4118 10500-10504 Protein denotes WWOX
T4117 10456-10460 Protein denotes Wwox
T4116 10232-10236 Protein denotes Wwox
T4115 10102-10107 Protein denotes c-Jun
T4114 10093-10096 Protein denotes p73
T4113 10087-10091 Protein denotes AP-2
T4112 10054-10058 Protein denotes WWOX
T4111 9936-9941 Protein denotes RUNX4
T4110 9929-9934 Protein denotes c-Jun
T4109 9921-9927 Protein denotes SIMPLE
T4108 9914-9919 Protein denotes Ezrin
T4107 9907-9912 Protein denotes ErbB4
T4106 9902-9905 Protein denotes p73
T4105 9895-9900 Protein denotes AP-2γ
T4104 9828-9832 Protein denotes WWOX
T4103 9653-9657 Protein denotes WWOX
T4102 9234-9238 Protein denotes WWOX
T4101 7300-7304 Protein denotes WWOX
T4100 7024-7028 Protein denotes WWOX
T4099 6899-6903 Protein denotes Wwox
T4098 6894-6898 Protein denotes WWOX
T4097 6859-6863 Protein denotes WOX1
T4096 6851-6854 Protein denotes FOR
T4095 6845-6849 Protein denotes WWOX
T4094 6799-6834 Protein denotes WW domain-containing oxidoreductase
T4093 6712-6716 Protein denotes WWOX
T4092 6704-6707 Protein denotes p53
T2073 6524-6529 Protein denotes CD133
T2072 6376-6381 Protein denotes CD133
T2071 5837-5842 Protein denotes STAT3
T2070 5818-5823 Protein denotes STAT3
T2069 5639-5643 Protein denotes MGMT
T2068 5533-5538 Protein denotes IFN-β
T2067 5519-5531 Protein denotes Interferon-β
T2066 5047-5051 Protein denotes MGMT
T2065 4393-4396 Protein denotes p53
T2064 4177-4188 Protein denotes MicroRNA-21
T2063 4098-4107 Protein denotes caspase-3
T2062 4082-4087 Protein denotes Bcl-2
T2061 4078-4081 Protein denotes Bax
T2060 4058-4069 Protein denotes microRNA-21
T2059 3971-3975 Protein denotes MGMT
T2058 3926-3930 Protein denotes MGMT
T2057 3829-3833 Protein denotes MGMT
T2056 3520-3524 Protein denotes MGMT
T2055 3260-3264 Protein denotes MGMT
T2054 3158-3162 Protein denotes MGMT
T2053 3118-3156 Protein denotes O6-methylguanine-DNA methyltransferase
T2052 2946-2951 Protein denotes MAPO2
T2051 2844-2852 Protein denotes C1orf201
T2050 2837-2842 Protein denotes MAPO2
T2049 2557-2562 Protein denotes Bcl-2
T2048 2542-2547 Protein denotes Bcl-2
T165 988-991 Protein denotes p53
T164 945-949 Protein denotes WWOX
T163 912-916 Protein denotes WWOX
T162 859-862 Protein denotes p53
T161 793-797 Protein denotes WWOX
T160 785-788 Protein denotes p53
T159 722-725 Protein denotes p53
T158 665-669 Protein denotes WWOX
T157 660-663 Protein denotes p53
T156 577-581 Protein denotes WWOX
T155 382-386 Protein denotes WWOX
T154 301-305 Protein denotes WOX1
T153 294-297 Protein denotes FOR
T152 288-292 Protein denotes WWOX
T151 252-287 Protein denotes WW domain-containing oxidoreductase
T150 106-109 Protein denotes p53