PMC:3585731 / 7333-8203 JSONTXT

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Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T28516","span":{"begin":747,"end":751},"obj":"Protein"},{"id":"T28515","span":{"begin":138,"end":142},"obj":"Protein"},{"id":"T28514","span":{"begin":53,"end":58},"obj":"Protein"},{"id":"T28513","span":{"begin":44,"end":48},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T28693","span":{"begin":747,"end":751},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T28692","span":{"begin":138,"end":142},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T28691","span":{"begin":642,"end":645},"obj":"http://www.uniprot.org/uniprot/Q788Q8"},{"id":"T28690","span":{"begin":44,"end":48},"obj":"http://www.uniprot.org/uniprot/Q788Q8"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

{"project":"UBERON-AE","denotations":[{"id":"T28503","span":{"begin":763,"end":768},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"T28502","span":{"begin":602,"end":607},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"T28501","span":{"begin":510,"end":515},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"T28500","span":{"begin":187,"end":192},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"},{"id":"T28499","span":{"begin":168,"end":173},"obj":"http://purl.obolibrary.org/obo/UBERON_0001977"}],"text":"10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

{"project":"GO-BP","denotations":[{"id":"T28525","span":{"begin":714,"end":719},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T28524","span":{"begin":709,"end":731},"obj":"http://purl.obolibrary.org/obo/GO_0071888"},{"id":"T28523","span":{"begin":709,"end":731},"obj":"http://purl.obolibrary.org/obo/GO_0043276"},{"id":"T28522","span":{"begin":709,"end":719},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T28521","span":{"begin":478,"end":484},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T28520","span":{"begin":319,"end":330},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T28519","span":{"begin":67,"end":78},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T28518","span":{"begin":319,"end":330},"obj":"http://purl.obolibrary.org/obo/GO_0070266"},{"id":"T28517","span":{"begin":67,"end":78},"obj":"http://purl.obolibrary.org/obo/GO_0070266"}],"text":"10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

{"project":"GO-CC","denotations":[{"id":"T28528","span":{"begin":709,"end":713},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T28527","span":{"begin":210,"end":214},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T28526","span":{"begin":114,"end":119},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

{"project":"sentences","denotations":[{"id":"T28508","span":{"begin":832,"end":870},"obj":"Sentence"},{"id":"T28507","span":{"begin":293,"end":831},"obj":"Sentence"},{"id":"T28506","span":{"begin":210,"end":292},"obj":"Sentence"},{"id":"T28505","span":{"begin":105,"end":209},"obj":"Sentence"},{"id":"T28504","span":{"begin":44,"end":104},"obj":"Sentence"},{"id":"T47","span":{"begin":0,"end":104},"obj":"Sentence"},{"id":"T48","span":{"begin":105,"end":209},"obj":"Sentence"},{"id":"T49","span":{"begin":210,"end":292},"obj":"Sentence"},{"id":"T50","span":{"begin":293,"end":831},"obj":"Sentence"},{"id":"T51","span":{"begin":832,"end":870},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

{"project":"simple1","denotations":[{"id":"T28536","span":{"begin":747,"end":751},"obj":"Protein"},{"id":"T28535","span":{"begin":138,"end":142},"obj":"Protein"},{"id":"T28534","span":{"begin":53,"end":58},"obj":"Protein"},{"id":"T28533","span":{"begin":44,"end":48},"obj":"Protein"}],"text":"10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T28689","span":{"begin":747,"end":751},"obj":"Protein"},{"id":"T28688","span":{"begin":138,"end":142},"obj":"Protein"},{"id":"T28687","span":{"begin":53,"end":58},"obj":"Protein"},{"id":"T28686","span":{"begin":44,"end":48},"obj":"Protein"}],"text":"10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T28705","span":{"begin":747,"end":751},"obj":"Protein"},{"id":"T28704","span":{"begin":138,"end":142},"obj":"Protein"},{"id":"T28703","span":{"begin":53,"end":58},"obj":"Protein"},{"id":"T28702","span":{"begin":44,"end":48},"obj":"Protein"}],"text":"10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

{"project":"DLUT931","denotations":[{"id":"T28697","span":{"begin":747,"end":751},"obj":"Protein"},{"id":"T28696","span":{"begin":138,"end":142},"obj":"Protein"},{"id":"T28695","span":{"begin":53,"end":58},"obj":"Protein"},{"id":"T28694","span":{"begin":44,"end":48},"obj":"Protein"}],"text":"10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.\n(A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions. Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay. The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866. In all graphs, average±SD was plotted."}

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