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PMC:3585731 / 5289-10103 JSONTXT

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testone

Id Subject Object Predicate Lexical cue
T28489 2768-2775 Positive_regulation denotes induced
T28488 2791-2795 Protein denotes TNFα
T28487 2182-2186 Protein denotes TNFα
T28486 2097-2102 Protein denotes IGF-1
T28485 2088-2092 Protein denotes bFGF
T2893 4491-4499 Positive_regulation denotes promoted
T2892 4306-4313 Positive_regulation denotes induced
T2891 4269-4278 Negative_regulation denotes inhibitor
T2890 4173-4180 Positive_regulation denotes induced
T2889 3957-3964 Positive_regulation denotes induced
T2888 3322-3329 Positive_regulation denotes induced
T2887 3005-3014 Negative_regulation denotes inhibitor
T2886 841-848 Positive_regulation denotes induced
T2885 4503-4507 Protein denotes bFGF
T2884 4301-4305 Protein denotes TNFα
T2883 4255-4268 Protein denotes bFGF receptor
T2882 4130-4134 Protein denotes bFGF
T2881 4030-4059 Protein denotes bFGF receptor tyrosine kinase
T2880 3928-3932 Protein denotes bFGF
T2879 3802-3806 Protein denotes RIP1
T2878 3757-3761 Protein denotes bFGF
T2877 3703-3707 Protein denotes TNFα
T2876 3564-3568 Protein denotes RIP1
T2875 3418-3422 Protein denotes RIP1
T2874 3317-3321 Protein denotes TNFα
T2873 3018-3022 Protein denotes RIP1
T2872 1989-1993 Protein denotes TNFα
T2871 1853-1857 Protein denotes TNFα
T2870 1792-1796 Protein denotes bFGF
T2869 1655-1658 Protein denotes EGF
T2868 1640-1645 Protein denotes IGF-1
T2867 1631-1635 Protein denotes bFGF
T2866 1437-1441 Protein denotes bFGF
T2865 1212-1216 Protein denotes CYLD
T2864 1192-1211 Protein denotes RIP1 deubiquitinase
T2863 1172-1176 Protein denotes RIP1
T2862 1122-1131 Protein denotes caspase-8
T2861 712-716 Protein denotes FADD
T2860 698-707 Protein denotes caspase-8
T2859 227-236 Protein denotes caspase-8
T2858 183-187 Protein denotes TNFα
T2857 0-30 Protein denotes Basic Fibroblast Growth Factor
R1987 T2873 T2887 themeOf RIP1,inhibitor
R1988 T2874 T2888 causeOf TNFα,induced
R1989 T2883 T2891 themeOf bFGF receptor,inhibitor
R1990 T2885 T2893 causeOf bFGF,promoted
R19753 T28488 T28489 causeOf TNFα,induced

2_test

Id Subject Object Predicate Lexical cue
23469174-19109899-90505413 189-191 19109899 denotes 10
23469174-16408008-90505414 195-197 16408008 denotes 17
23469174-19109899-90505415 386-388 19109899 denotes 10
23469174-15131264-90505416 392-394 15131264 denotes 14
23469174-16408008-90505417 563-565 16408008 denotes 17
23469174-21368762-90505418 718-720 21368762 denotes 18
23469174-21368763-90505419 724-726 21368763 denotes 19
23469174-21368761-90505420 730-732 21368761 denotes 20
23469174-19632174-90505421 1218-1220 19632174 denotes 21
23469174-22037414-90505422 1224-1226 22037414 denotes 22
23469174-19556857-90505423 1290-1292 19556857 denotes 16
23469174-18408713-90505424 3058-3060 18408713 denotes 23
23469174-16153840-90505425 3064-3066 16153840 denotes 24
23469174-22695613-90505426 3170-3172 22695613 denotes 15
23469174-18408713-90505427 3606-3608 18408713 denotes 23

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T3906 4808-4813 NN denotes death
T28685 2906-2913 VB denotes plotted
T28684 2902-2905 VB denotes was
T28683 2891-2901 NN denotes average±SD
T28682 2889-2890 -COMMA- denotes ,
T28681 2883-2889 NN denotes graphs
T28680 2879-2882 DT denotes all
T28679 2876-2878 IN denotes In
T28678 2866-2874 NN denotes PD166866
T28677 2863-2865 NN denotes µM
T28676 2860-2862 CD denotes 20
T28675 2856-2859 CC denotes and
T28674 2847-2855 NN denotes PD173074
T28673 2844-2846 NN denotes µM
T28672 2842-2843 CD denotes 2
T28671 2839-2841 IN denotes of
T28670 2830-2838 NN denotes presence
T28669 2826-2829 DT denotes the
T28668 2823-2825 IN denotes in
T28667 2813-2822 NN denotes condition
T28666 2807-2812 NN denotes serum
T28665 2802-2806 JJ denotes full
T28664 2796-2801 IN denotes under
T28663 2791-2795 NN denotes TNFα
T28662 2788-2790 CC denotes or
T28661 2779-2787 NN denotes zVAD.fmk
T28660 2776-2778 IN denotes by
T28659 2768-2775 VB denotes induced
T28658 2764-2767 VB denotes was
T28657 2758-2763 NN denotes death
T28656 2753-2757 NN denotes Cell
T28655 2751-2752 -RRB- denotes )
T28654 2750-2751 NN denotes D
T28653 2749-2750 -LRB- denotes (
T28652 2742-2748 NN denotes assay.
T28651 2732-2741 NN denotes viability
T28650 2729-2731 IN denotes by
T28649 2720-2728 VB denotes followed
T28648 2716-2719 NN denotes hrs
T28647 2713-2715 CD denotes 24
T28646 2709-2712 IN denotes for
T28645 2704-2708 DT denotes both
T28644 2701-2703 CC denotes or
T28643 2699-2700 -COMMA- denotes ,
T28642 2691-2699 NN denotes zVAD.fmk
T28641 2689-2690 -COMMA- denotes ,
T28640 2686-2689 NN denotes FGF
T28639 2681-2685 IN denotes with
T28638 2673-2680 VB denotes treated
T28637 2668-2672 VB denotes were
T28636 2657-2667 NN denotes conditions
T28635 2652-2656 JJ denotes free
T28634 2646-2651 NN denotes serum
T28633 2640-2645 IN denotes under
T28632 2634-2639 NN denotes Cells
T28631 2632-2633 -RRB- denotes )
T28630 2631-2632 NN denotes C
T28629 2630-2631 -LRB- denotes (
T28628 2619-2629 NN denotes viability.
T28627 2614-2618 NN denotes cell
T28626 2611-2613 IN denotes of
T28625 2599-2610 NN denotes measurement
T28624 2596-2598 IN denotes by
T28623 2587-2595 VB denotes followed
T28622 2583-2586 NN denotes hrs
T28621 2580-2582 CD denotes 24
T28620 2576-2579 IN denotes for
T28619 2565-2575 NN denotes conditions
T28618 2560-2564 JJ denotes free
T28617 2554-2559 NN denotes serum
T28616 2548-2553 IN denotes under
T28615 2542-2547 NN denotes Nec-1
T28614 2538-2541 CC denotes and
T28613 2536-2537 -COMMA- denotes ,
T28612 2529-2536 NN denotes factors
T28611 2522-2528 NN denotes growth
T28610 2512-2521 VB denotes indicated
T28609 2508-2511 DT denotes the
T28608 2506-2507 -COMMA- denotes ,
T28607 2498-2506 NN denotes zVAD.fmk
T28606 2493-2497 IN denotes with
T28605 2485-2492 VB denotes treated
T28604 2480-2484 VB denotes were
T28603 2474-2479 NN denotes Cells
T28602 2472-2473 -RRB- denotes )
T28601 2471-2472 NN denotes B
T28600 2470-2471 -LRB- denotes (
T28599 2461-2469 NN denotes figures.
T28598 2457-2460 DT denotes the
T28597 2454-2456 IN denotes in
T28596 2444-2453 VB denotes indicated
T28554 2182-2186 NN denotes TNFα
T28553 2177-2181 IN denotes with
T28552 2169-2176 VB denotes treated
T28551 2164-2168 VB denotes were
T28550 2158-2163 NN denotes cells
T28549 2153-2157 NN denotes L929
T28548 2151-2152 -RRB- denotes )
T28547 2150-2151 NN denotes A
T28546 2149-2150 -LRB- denotes (
T28545 2139-2147 NN denotes zVAD.fmk
T28544 2134-2138 IN denotes with
T28543 2126-2133 NN denotes concert
T28542 2123-2125 IN denotes in
T28541 2111-2122 NN denotes necroptosis
T28540 2103-2110 VB denotes promote
T28539 2097-2102 NN denotes IGF-1
T28538 2093-2096 CC denotes and
T28537 2088-2092 NN denotes bFGF
T28595 2441-2443 CC denotes or
T28594 2433-2440 NN denotes section
T28593 2424-2431 NNP denotes Methods
T28592 2420-2423 CC denotes and
T28591 2410-2419 NNP denotes Materials
T28590 2405-2408 DT denotes the
T28589 2402-2404 IN denotes in
T28588 2395-2401 VB denotes listed
T28587 2391-2394 VB denotes are
T28586 2384-2390 NN denotes agents
T28585 2363-2383 JJ denotes necroptosis-inducing
T28584 2359-2362 DT denotes all
T28583 2356-2358 IN denotes of
T28582 2341-2355 NN denotes concentrations
T28581 2337-2340 DT denotes The
T28580 2330-2335 NN denotes assay
T28579 2320-2329 NN denotes Viability
T28578 2306-2319 JJ denotes CellTiter-Glo
T28577 2302-2305 DT denotes the
T28576 2296-2301 VB denotes using
T28575 2293-2295 NN denotes hr
T28574 2290-2292 CD denotes 24
T28573 2284-2289 IN denotes after
T28572 2273-2283 VB denotes determined
T28571 2269-2272 VB denotes was
T28570 2259-2268 NN denotes viability
T28569 2254-2258 NN denotes Cell
T28568 2242-2252 NN denotes conditions
T28567 2237-2241 JJ denotes free
T28566 2231-2236 NN denotes serum
T28565 2228-2230 CC denotes or
T28564 2226-2227 -RRB- denotes )
T28563 2223-2226 NN denotes FBS
T28562 2221-2222 NN denotes %
T28561 2219-2221 CD denotes 10
T28560 2218-2219 -LRB- denotes (
T28559 2212-2217 NN denotes serum
T28558 2205-2211 JJ denotes normal
T28557 2199-2204 IN denotes under
T28556 2190-2198 NN denotes zVAD.fmk
T28555 2187-2189 CC denotes or
T3905 4796-4807 JJ denotes necroptotic
T3904 4793-4795 TO denotes to
T3903 4782-4792 VB denotes contribute
T3902 4779-4781 TO denotes to
T3901 4772-4778 VB denotes appear
T3900 4764-4771 NN denotes factors
T3899 4757-4763 NN denotes growth
T3898 4746-4756 JJ denotes particular
T3897 4743-4745 IN denotes by
T3896 4734-4742 VB denotes mediated
T3895 4727-4733 NN denotes events
T3894 4717-4726 NN denotes signaling
T3893 4708-4716 JJ denotes specific
T3892 4706-4707 -COMMA- denotes ,
T3891 4699-4706 RB denotes Instead
T3890 4692-4697 VB denotes occur
T3889 4689-4691 TO denotes to
T3888 4683-4688 NN denotes death
T3887 4675-4682 VB denotes allowed
T3886 4667-4674 NN denotes factors
T3885 4660-4666 NN denotes growth
T3884 4656-4659 DT denotes all
T3883 4652-4655 RB denotes not
T3882 4646-4651 IN denotes since
T3881 4636-4645 NN denotes signaling
T3880 4629-4635 NN denotes factor
T3879 4622-4628 NN denotes growth
T3878 4619-4621 IN denotes of
T3877 4607-4618 NN denotes consequence
T3876 4600-4606 JJ denotes simple
T3875 4598-4599 DT denotes a
T3874 4594-4597 RB denotes not
T3873 4591-4593 VB denotes is
T3872 4589-4590 -COMMA- denotes ,
T3871 4582-4589 RB denotes however
T3870 4580-4581 -COMMA- denotes ,
T3869 4569-4580 NN denotes necroptosis
T3868 4566-4568 IN denotes of
T3867 4556-4565 NN denotes induction
T3866 4552-4555 DT denotes The
T3865 4540-4550 NN denotes conditions
T3864 4535-4539 JJ denotes free
T3863 4529-4534 NN denotes serum
T3862 4525-4528 CC denotes and
T3861 4519-4524 NN denotes serum
T3860 4514-4518 CC denotes both
T3859 4508-4513 IN denotes under
T3858 4503-4507 NN denotes bFGF
T3857 4500-4502 IN denotes by
T3856 4491-4499 VB denotes promoted
T3855 4488-4490 VB denotes is
T3854 4479-4487 NN denotes zVAD.fmk
T3853 4476-4478 IN denotes by
T3852 4464-4475 NN denotes necroptosis
T3851 4461-4463 IN denotes of
T3850 4451-4460 NN denotes induction
T3849 4447-4450 DT denotes the
T3848 4442-4446 IN denotes that
T3847 4434-4441 VB denotes suggest
T3846 4429-4433 NN denotes data
T3845 4423-4428 DT denotes these
T3844 4421-4422 -COMMA- denotes ,
T3843 4414-4421 RB denotes Overall
T3842 4411-4412 -RRB- denotes )
T3841 4409-4411 NN denotes 1A
T3840 4404-4408 NN denotes Fig.
T3839 4403-4404 -LRB- denotes (
T3838 4395-4402 NN denotes pathway
T3837 4390-4394 DT denotes this
T3836 4386-4389 IN denotes for
T3835 4374-4385 JJ denotes dispensable
T3834 4368-4373 VB denotes being
T3833 4360-4367 NN denotes factors
T3832 4353-4359 NN denotes growth
T3831 4348-4352 IN denotes with
T3830 4337-4347 JJ denotes consistent
T3829 4335-4336 -COMMA- denotes ,
T3828 4334-4335 -RRB- denotes )
T3827 4332-4334 NN denotes 1D
T3826 4327-4331 NN denotes Fig.
T3825 4326-4327 -LRB- denotes (
T3824 4314-4325 NN denotes necroptosis
T3823 4301-4313 JJ denotes TNFα-induced
T3822 4291-4300 VB denotes attenuate
T3821 4288-4290 TO denotes to
T3820 4283-4287 JJ denotes able
T3819 4279-4282 VB denotes was
T3818 4269-4278 NN denotes inhibitor
T3817 4260-4268 NN denotes receptor
T3816 4255-4259 NN denotes bFGF
T3815 4247-4254 CC denotes neither
T3814 4245-4246 -COMMA- denotes ,
T3813 4237-4245 NN denotes contrast
T3812 4234-4236 IN denotes In
T3811 4231-4232 -RRB- denotes )
T3810 4229-4231 NN denotes 1D
T3809 4224-4228 NNP denotes Fig.
T3808 4223-4224 -LRB- denotes (
T3807 4212-4222 NN denotes conditions
T3806 4206-4211 NN denotes serum
T3805 4199-4205 JJ denotes normal
T3804 4193-4198 IN denotes under
T3803 4181-4192 NN denotes necroptosis
T3802 4164-4180 JJ denotes zVAD.fmk-induced
T3801 4154-4163 VB denotes inhibited
T3800 4145-4153 RB denotes strongly
T3799 4135-4144 NN denotes signaling
T3798 4130-4134 NN denotes bFGF
T3797 4127-4129 IN denotes of
T3796 4116-4126 NN denotes inhibition
T3795 4111-4115 IN denotes that
T3794 4100-4110 VB denotes determined
T3793 4096-4099 CC denotes and
T3792 4094-4095 -COMMA- denotes ,
T3791 4093-4094 -RRB- denotes )
T3790 4085-4093 NN denotes PD166866
T3789 4081-4084 CC denotes and
T3788 4072-4080 NN denotes PD173074
T3787 4071-4072 -LRB- denotes (
T3786 4060-4070 NN denotes inhibitors
T3785 4053-4059 NN denotes kinase
T3784 4044-4052 NN denotes tyrosine
T3783 4035-4043 NN denotes receptor
T3782 4030-4034 NN denotes bFGF
T3781 4026-4029 CD denotes two
T3780 4021-4025 VB denotes used
T3779 4018-4020 PRP denotes We
T3778 4015-4016 -RRB- denotes )
T3777 4012-4015 NN denotes FBS
T3776 4010-4011 NN denotes %
T3775 4008-4010 CD denotes 10
T3774 4007-4008 -LRB- denotes (
T3773 3996-4006 NN denotes conditions
T3772 3990-3995 NN denotes serum
T3771 3983-3989 JJ denotes normal
T3770 3977-3982 IN denotes under
T3769 3965-3976 NN denotes necroptosis
T3768 3948-3964 JJ denotes zVAD.fmk-induced
T3767 3945-3947 TO denotes to
T3766 3933-3944 VB denotes contributes
T3765 3928-3932 NN denotes bFGF
T3764 3920-3927 IN denotes whether
T3763 3911-3919 VB denotes examined
T3762 3906-3910 RB denotes next
T3761 3903-3905 PRP denotes We
T3760 3891-3901 NN denotes conditions
T3759 3886-3890 JJ denotes free
T3758 3880-3885 NN denotes serum
T3704 3576-3586 JJ denotes inhibitory
T3703 3569-3575 NN denotes kinase
T3702 3564-3568 NN denotes RIP1
T3701 3561-3563 IN denotes of
T3700 3556-3560 NN denotes loss
T3699 3547-3555 JJ denotes complete
T3698 3540-3546 RB denotes almost
T3697 3537-3539 TO denotes to
T3696 3531-3536 VB denotes leads
T3695 3526-3530 WDT denotes that
T3694 3520-3525 NN denotes group
T3693 3511-3519 NN denotes N-methyl
T3692 3505-3510 JJ denotes extra
T3691 3502-3504 DT denotes an
T3690 3493-3501 VB denotes contains
T3689 3487-3492 WDT denotes which
T3688 3485-3486 -COMMA- denotes ,
T3687 3484-3485 -RRB- denotes )
T3686 3481-3484 NN denotes S1A
T3685 3476-3480 NN denotes Fig.
T3684 3475-3476 -LRB- denotes (
T3683 3473-3474 -RRB- denotes )
T3682 3467-3473 NN denotes Nec-1i
T3681 3466-3467 -LRB- denotes (
T3680 3452-3465 NN denotes 7-Cl-O-Nec-1i
T3679 3450-3451 -COMMA- denotes ,
T3678 3444-3450 NN denotes analog
T3677 3435-3443 JJ denotes inactive
T3676 3432-3434 DT denotes an
T3675 3427-3431 VB denotes used
T3674 3424-3426 PRP denotes we
T3673 3422-3423 -COMMA- denotes ,
T3672 3418-3422 NN denotes RIP1
T3671 3415-3417 IN denotes of
T3670 3410-3414 NN denotes role
T3669 3406-3409 DT denotes the
T3668 3397-3405 VB denotes validate
T3667 3389-3396 RB denotes further
T3666 3386-3388 TO denotes To
T3665 3383-3384 -RRB- denotes )
T3664 3380-3383 NN denotes S1B
T3663 3378-3379 -COMMA- denotes ,
T3662 3376-3378 NN denotes 1B
T3661 3371-3375 NNP denotes Fig.
T3660 3370-3371 -LRB- denotes (
T3659 3359-3369 NN denotes conditions
T3658 3353-3358 NN denotes serum
T3657 3348-3352 JJ denotes full
T3656 3342-3347 IN denotes under
T3655 3330-3341 NN denotes necroptosis
T3654 3317-3329 JJ denotes TNFα-induced
T3653 3313-3316 CC denotes and
T3652 3304-3312 NN denotes zVAD.fmk
T3651 3299-3303 CC denotes both
T3650 3295-3298 CC denotes and
T3649 3289-3294 NN denotes cells
T3648 3284-3288 NN denotes L929
T3647 3281-3283 IN denotes in
T3646 3270-3280 NN denotes conditions
T3645 3265-3269 JJ denotes free
T3644 3259-3264 NN denotes serum
T3643 3253-3258 IN denotes under
T3642 3241-3252 NN denotes necroptosis
T3641 3217-3240 JJ denotes factor/zVAD.fmk-induced
T3640 3210-3216 NN denotes growth
T3639 3202-3209 VB denotes blocked
T3638 3190-3201 RB denotes efficiently
T3637 3180-3189 NN denotes inhibitor
T3636 3175-3179 DT denotes This
T3635 3172-3173 -RRB- denotes ]
T3634 3170-3172 CD denotes 15
T3633 3169-3170 -LRB- denotes [
T3632 3161-3168 NN denotes kinases
T3631 3155-3160 JJ denotes human
T3630 3151-3154 CD denotes 400
T3629 3146-3150 IN denotes than
T3628 3141-3145 JJ denotes more
T3627 3138-3140 IN denotes of
T3626 3132-3137 NN denotes panel
T3625 3130-3131 DT denotes a
T3624 3122-3129 IN denotes against
T3623 3112-3121 VB denotes validated
T3622 3104-3111 RB denotes further
T3621 3099-3103 VB denotes been
T3620 3095-3098 VB denotes has
T3619 3083-3094 NN denotes selectivity
T3618 3079-3082 PRP-DOLLAR- denotes its
T3617 3077-3078 -COMMA- denotes ,
T3616 3069-3077 RB denotes Recently
T3615 3066-3067 -RRB- denotes ]
T3614 3064-3066 CD denotes 24
T3613 3063-3064 -LRB- denotes [
T3612 3061-3062 -COMMA- denotes ,
T3611 3060-3061 -RRB- denotes ]
T3610 3058-3060 CD denotes 23
T3609 3057-3058 -LRB- denotes [
T3608 3055-3056 -RRB- denotes )
T3607 3052-3055 NN denotes S1A
T3606 3047-3051 NN denotes Fig.
T3605 3046-3047 -LRB- denotes (
T3604 3034-3045 NN denotes necroptosis
T3603 3030-3033 CC denotes and
T3602 3023-3029 NN denotes kinase
T3601 3018-3022 NN denotes RIP1
T3600 3015-3017 IN denotes of
T3599 3005-3014 NN denotes inhibitor
T3598 2995-3004 JJ denotes selective
T3597 2991-2994 CC denotes and
T3596 2984-2990 JJ denotes potent
T3595 2982-2983 DT denotes a
T3594 2979-2981 IN denotes as
T3593 2977-2978 -RRB- denotes )
T3592 2972-2977 NN denotes Nec-1
T3591 2971-2972 -LRB- denotes (
T3590 2958-2970 NN denotes 7-Cl-O-Nec-1
T3589 2955-2957 IN denotes of
T3588 2943-2954 NN denotes development
T3587 2939-2942 DT denotes the
T3586 2929-2938 VB denotes described
T3585 2926-2928 PRP denotes we
T3584 2915-2925 RB denotes Previously
T3583 2037-2042 NN denotes cells
T3582 2032-2036 NN denotes L929
T3581 2029-2031 IN denotes in
T3580 2023-2028 NN denotes death
T3579 2011-2022 JJ denotes necroptotic
T3578 2007-2010 IN denotes for
T3577 1998-2006 VB denotes required
T3576 1994-1997 VB denotes are
T3575 1989-1993 NN denotes TNFα
T3574 1986-1988 CC denotes or
T3573 1977-1985 NN denotes zVAD.fmk
T3572 1973-1976 CC denotes and
T3571 1965-1972 NN denotes factors
T3570 1958-1964 NN denotes growth
T3569 1951-1957 CC denotes either
T3568 1946-1950 IN denotes that
T3567 1935-1945 VB denotes suggesting
T3566 1933-1934 -COMMA- denotes ,
T3565 1932-1933 -RRB- denotes )
T3564 1930-1932 NN denotes 1A
T3563 1925-1929 NN denotes Fig.
T3562 1924-1925 -LRB- denotes (
T3561 1918-1923 NN denotes serum
T3560 1915-1917 IN denotes of
T3559 1907-1914 NN denotes absence
T3558 1903-1906 DT denotes the
T3557 1900-1902 IN denotes in
T3556 1888-1899 RB denotes efficiently
T3555 1880-1887 RB denotes equally
T3554 1868-1879 NN denotes necroptosis
T3553 1858-1867 VB denotes triggered
T3552 1853-1857 NN denotes TNFα
T3551 1851-1852 -COMMA- denotes ,
T3550 1843-1851 NN denotes contrast
T3549 1840-1842 IN denotes In
T3548 1837-1838 -RRB- denotes )
T3547 1835-1837 NN denotes 1C
T3546 1830-1834 NN denotes Fig.
T3545 1829-1830 -LRB- denotes (
T3544 1823-1828 NN denotes death
T3543 1818-1822 NN denotes cell
T3542 1811-1817 VB denotes induce
T3541 1807-1810 RB denotes not
T3540 1803-1806 VB denotes did
T3539 1797-1802 RB denotes alone
T3538 1792-1796 NN denotes bFGF
T3537 1789-1791 IN denotes as
T3536 1787-1788 -COMMA- denotes ,
T3535 1779-1787 NN denotes activity
T3534 1771-1778 NN denotes caspase
T3533 1768-1770 IN denotes of
T3532 1757-1767 NN denotes inhibition
T3531 1753-1756 DT denotes the
T3530 1744-1752 VB denotes required
T3529 1732-1743 NN denotes necroptosis
T3528 1715-1731 JJ denotes factor-dependent
T3527 1708-1714 NN denotes growth
T3526 1706-1707 -COMMA- denotes ,
T3525 1695-1706 RB denotes Furthermore
T3524 1692-1693 -RRB- denotes )
T3523 1690-1692 NN denotes 1B
T3522 1685-1689 NN denotes Fig.
T3521 1684-1685 -LRB- denotes (
T3520 1678-1683 NN denotes death
T3519 1669-1677 VB denotes promoted
T3518 1667-1668 -RRB- denotes )
T3517 1663-1667 NN denotes PDGF
T3516 1659-1662 CC denotes and
T3515 1655-1658 NN denotes EGF
T3514 1651-1654 RB denotes not
T3513 1647-1650 CC denotes but
T3512 1645-1646 -COMMA- denotes ,
T3511 1640-1645 NN denotes IGF-1
T3510 1636-1639 CC denotes and
T3509 1631-1635 NN denotes bFGF
T3508 1630-1631 -LRB- denotes (
T3507 1622-1629 NN denotes factors
T3506 1615-1621 NN denotes growth
T3505 1610-1614 DT denotes some
T3504 1605-1609 RB denotes only
T3503 1602-1604 IN denotes as
T3502 1600-1601 -COMMA- denotes ,
T3501 1591-1600 NN denotes signaling
T3500 1584-1590 NN denotes factor
T3499 1577-1583 NN denotes growth
T3498 1573-1576 IN denotes for
T3497 1561-1572 NN denotes requirement
T3496 1553-1560 JJ denotes generic
T3495 1551-1552 DT denotes a
T3494 1543-1550 VB denotes reflect
T3493 1539-1542 RB denotes not
T3492 1534-1538 VB denotes does
T3491 1529-1533 DT denotes this
T3490 1527-1528 -COMMA- denotes ,
T3489 1514-1527 RB denotes Interestingly
T3433 1226-1227 -RRB- denotes ]
T3432 1224-1226 CD denotes 22
T3431 1223-1224 -LRB- denotes [
T3430 1221-1222 -COMMA- denotes ,
T3429 1220-1221 -RRB- denotes ]
T3428 1218-1220 CD denotes 21
T3427 1217-1218 -LRB- denotes [
T3426 1212-1216 NN denotes CYLD
T3425 1197-1211 NN denotes deubiquitinase
T3424 1192-1196 NN denotes RIP1
T3423 1188-1191 DT denotes the
T3422 1184-1187 CC denotes and
T3421 1177-1183 NN denotes kinase
T3420 1172-1176 NN denotes RIP1
T3419 1160-1171 VB denotes inactivates
T3418 1156-1159 CC denotes and
T3417 1148-1155 VB denotes cleaves
T3416 1142-1147 WDT denotes which
T3415 1140-1141 -COMMA- denotes ,
T3414 1132-1140 NN denotes activity
T3413 1122-1131 NN denotes caspase-8
T3412 1117-1121 RB denotes once
T3411 1105-1116 NN denotes necroptosis
T3410 1097-1104 VB denotes promote
T3409 1092-1096 WDT denotes that
T3408 1084-1091 NN denotes factors
T3407 1075-1083 JJ denotes cellular
T3406 1065-1074 JJ denotes intrinsic
T3405 1062-1064 CC denotes or
T3404 1052-1061 JJ denotes extrinsic
T3403 1048-1051 DT denotes the
T3402 1040-1047 VB denotes explore
T3401 1037-1039 TO denotes to
T3400 1034-1036 PRP denotes us
T3399 1025-1033 VB denotes prompted
T3398 1021-1024 CC denotes and
T3397 1009-1020 NN denotes necroptosis
T3396 1001-1008 VB denotes trigger
T3395 998-1000 TO denotes to
T3394 987-997 JJ denotes sufficient
T3393 984-986 VB denotes is
T3392 978-983 NN denotes cells
T3391 970-977 JJ denotes healthy
T3390 967-969 IN denotes in
T3389 958-966 NN denotes activity
T3388 950-957 NN denotes caspase
T3387 947-949 IN denotes of
T3386 942-946 NN denotes loss
T3385 938-941 DT denotes the
T3384 932-937 WRB denotes where
T3383 926-931 NN denotes cells
T3382 921-925 NN denotes L929
T3381 918-920 IN denotes in
T3380 905-917 NN denotes observations
T3379 901-904 DT denotes the
T3378 898-900 IN denotes of
T3377 886-897 JJ denotes reminiscent
T3376 882-885 VB denotes are
T3375 877-881 NN denotes data
T3374 871-876 DT denotes These
T3373 862-869 NN denotes embryos
T3372 857-861 NN denotes type
T3371 852-856 JJ denotes wild
T3370 849-851 IN denotes in
T3369 841-848 VB denotes induced
T3368 832-840 RB denotes normally
T3367 828-831 RB denotes not
T3366 825-827 VB denotes is
T3365 815-824 NN denotes apoptosis
T3364 808-814 IN denotes though
T3363 803-807 RB denotes even
T3362 795-802 NN denotes embryos
T3361 789-794 NN denotes E10.5
T3360 786-788 IN denotes of
T3359 780-785 NN denotes death
T3358 776-779 CC denotes and
T3357 764-775 NN denotes necroptosis
T3356 761-763 IN denotes of
T3355 751-760 NN denotes induction
T3354 744-750 JJ denotes robust
T3353 741-743 TO denotes to
T3352 735-740 VB denotes leads
T3351 733-734 -COMMA- denotes ,
T3350 732-733 -RRB- denotes ]
T3349 730-732 CD denotes 20
T3348 729-730 -LRB- denotes [
T3347 727-728 -COMMA- denotes ,
T3346 726-727 -RRB- denotes ]
T3345 724-726 CD denotes 19
T3344 723-724 -LRB- denotes [
T3343 721-722 -COMMA- denotes ,
T3342 720-721 -RRB- denotes ]
T3341 718-720 CD denotes 18
T3340 717-718 -LRB- denotes [
T3339 712-716 NN denotes FADD
T3338 708-711 CC denotes and
T3337 698-707 NN denotes caspase-8
T3336 695-697 IN denotes as
T3335 690-694 JJ denotes such
T3334 688-689 -COMMA- denotes ,
T3333 678-688 NN denotes regulators
T3332 668-677 JJ denotes apoptotic
T3331 665-667 IN denotes of
T3330 660-664 NN denotes loss
T3329 656-659 DT denotes the
T3328 651-655 IN denotes that
T3327 641-650 VB denotes suggested
T3326 637-640 VB denotes has
T3325 625-636 NN denotes development
T3324 619-624 NN denotes mouse
T3323 612-618 IN denotes during
T3322 606-611 NN denotes death
T3321 601-605 NN denotes cell
T3320 587-600 JJ denotes physiological
T3319 584-586 IN denotes of
T3318 575-583 NN denotes analysis
T3317 568-574 JJ denotes recent
T3316 566-567 -COMMA- denotes ,
T3315 565-566 -RRB- denotes ]
T3314 563-565 CD denotes 17
T3313 562-563 -LRB- denotes [
T3312 551-561 NN denotes inhibitors
T3311 541-550 NN denotes apoptosis
T3310 538-540 IN denotes of
T3309 529-537 NN denotes presence
T3308 525-528 DT denotes the
T3307 522-524 IN denotes in
T3306 514-521 NN denotes stimuli
T3305 500-513 JJ denotes pro-apoptotic
T3304 497-499 IN denotes by
T3303 487-496 VB denotes triggered
T3302 481-486 NN denotes death
T3301 476-480 NN denotes cell
T3300 473-475 IN denotes of
T3299 468-472 NN denotes form
T3298 460-467 JJ denotes back-up
T3297 458-459 DT denotes a
T3296 455-457 IN denotes as
T3295 444-454 VB denotes identified
T3294 434-443 RB denotes initially
T3293 430-433 VB denotes was
T3292 418-429 NN denotes necroptosis
T3291 412-417 IN denotes while
T3290 410-411 -COMMA- denotes ,
T3289 397-410 RB denotes Interestingly
T3288 394-395 -RRB- denotes ]
T3287 392-394 CD denotes 14
T3286 391-392 -LRB- denotes [
T3285 389-390 -COMMA- denotes ,
T3284 388-389 -RRB- denotes ]
T3283 386-388 CD denotes 10
T3282 385-386 -LRB- denotes [
T3281 379-384 NN denotes cells
T3280 373-378 DT denotes these
T3279 370-372 IN denotes in
T3278 358-369 NN denotes necroptosis
T3277 350-357 VB denotes trigger
T3276 347-349 TO denotes to
T3275 336-346 JJ denotes sufficient
T3274 333-335 VB denotes is
T3273 331-332 -COMMA- denotes ,
T3272 323-331 NN denotes zVAD.fmk
T3271 321-322 -COMMA- denotes ,
T3270 312-321 NN denotes inhibitor
T3269 300-311 NN denotes pan-caspase
T3268 296-299 DT denotes the
T3267 290-295 VB denotes using
T3266 287-289 IN denotes by
T3265 284-286 CC denotes or
T3264 274-283 NN denotes knockdown
T3263 268-273 NN denotes siRNA
T3262 260-267 IN denotes through
T3261 253-259 CC denotes either
T3260 251-252 -COMMA- denotes ,
T3259 246-251 RB denotes alone
T3258 237-245 NN denotes activity
T3257 227-236 NN denotes caspase-8
T3256 224-226 IN denotes of
T3255 213-223 NN denotes inhibition
T3254 211-212 -COMMA- denotes ,
T3253 203-211 NN denotes addition
T3252 200-202 IN denotes In
T3251 197-198 -RRB- denotes ]
T3250 195-197 CD denotes 17
T3249 194-195 -LRB- denotes [
T3248 192-193 -COMMA- denotes ,
T3247 191-192 -RRB- denotes ]
T3246 189-191 CD denotes 10
T3245 188-189 -LRB- denotes [
T3244 183-187 NN denotes TNFα
T3757 3876-3879 CC denotes and
T3756 3870-3875 NN denotes serum
T3755 3865-3869 CC denotes both
T3754 3859-3864 IN denotes under
T3753 3853-3858 NN denotes cells
T3752 3848-3852 NN denotes L929
T3751 3845-3847 IN denotes in
T3750 3833-3844 NN denotes necroptosis
T3749 3829-3832 IN denotes for
T3748 3817-3828 JJ denotes responsible
T3747 3814-3816 VB denotes is
T3746 3807-3813 NN denotes kinase
T3745 3802-3806 NN denotes RIP1
T3744 3797-3801 IN denotes that
T3743 3788-3796 VB denotes confirms
T3742 3783-3787 DT denotes This
T3741 3780-3781 -RRB- denotes )
T3740 3777-3780 NN denotes S1C
T3739 3772-3776 NN denotes Fig.
T3738 3771-3772 -LRB- denotes (
T3737 3757-3770 NN denotes bFGF/zVAD.fmk
T3736 3752-3756 IN denotes with
T3735 3744-3751 VB denotes treated
T3734 3733-3743 NN denotes conditions
T3733 3728-3732 JJ denotes free
T3732 3722-3727 NN denotes serum
T3731 3719-3721 CC denotes or
T3730 3717-3718 -RRB- denotes )
T3729 3714-3717 NN denotes S1B
T3728 3709-3713 NN denotes Fig.
T3727 3708-3709 -LRB- denotes (
T3726 3703-3707 NN denotes TNFα
T3725 3700-3702 CC denotes or
T3724 3691-3699 NN denotes zVAD.fmk
T3723 3686-3690 IN denotes with
T3722 3678-3685 VB denotes treated
T3721 3668-3677 NN denotes condtions
T3720 3662-3667 NN denotes serum
T3719 3656-3661 IN denotes under
T3718 3650-3655 NN denotes death
T3717 3645-3649 NN denotes cell
T3716 3640-3644 NN denotes L929
T3715 3632-3639 VB denotes protect
T3714 3629-3631 TO denotes to
T3713 3622-3628 JJ denotes unable
T3712 3618-3621 VB denotes was
T3711 3611-3617 NN denotes Nec-1i
T3710 3608-3609 -RRB- denotes ]
T3709 3606-3608 CD denotes 23
T3708 3605-3606 -LRB- denotes [
T3707 3599-3604 FW denotes vitro
T3706 3596-3598 FW denotes in
T3705 3587-3595 NN denotes activity
T3243 178-182 IN denotes with
T3242 166-177 NN denotes stimulation
T3241 156-165 VB denotes following
T3240 150-155 NN denotes death
T3239 145-149 NN denotes cell
T3238 133-144 JJ denotes necroptotic
T3237 125-132 VB denotes undergo
T3236 119-124 NN denotes cells
T3235 114-118 NN denotes L929
T3234 101-113 NN denotes fibrosarcoma
T3233 95-100 NN denotes mouse
T3232 90-94 IN denotes that
T3231 78-89 VB denotes established
T3230 73-77 VB denotes been
T3229 69-72 VB denotes has
T3228 66-68 PRP denotes It
T3227 60-65 NN denotes Cells
T3226 55-59 NN denotes L929
T3225 52-54 IN denotes in
T3224 40-51 NNP denotes Necroptosis
T3223 31-39 NNP denotes Promotes
T3222 24-30 NNP denotes Factor
T3221 17-23 NNP denotes Growth
T3220 6-16 NN denotes Fibroblast
T3488 1511-1512 -RRB- denotes )
T3487 1509-1511 NN denotes 1B
T3486 1504-1508 NNP denotes Fig.
T3485 1503-1504 -LRB- denotes (
T3484 1492-1502 NN denotes conditions
T3483 1487-1491 JJ denotes free
T3482 1481-1486 NN denotes serum
T3481 1475-1480 IN denotes under
T3480 1469-1474 NN denotes death
T3479 1461-1468 VB denotes induced
T3478 1452-1460 NN denotes zVAD.fmk
T3477 1443-1451 VB denotes restored
T3476 1441-1442 -COMMA- denotes ,
T3475 1437-1441 NN denotes bFGF
T3474 1434-1436 IN denotes as
T3473 1429-1433 JJ denotes such
T3472 1427-1428 -COMMA- denotes ,
T3471 1420-1427 NN denotes factors
T3470 1413-1419 NN denotes growth
T3469 1410-1412 IN denotes of
T3468 1401-1409 NN denotes addition
T3467 1397-1400 DT denotes The
T3466 1394-1395 -RRB- denotes )
T3465 1392-1394 NN denotes 1A
T3464 1387-1391 NN denotes Fig.
T3463 1386-1387 -LRB- denotes (
T3462 1377-1385 NN denotes zVAD.fmk
T3461 1374-1376 TO denotes to
T3460 1365-1373 NN denotes response
T3459 1362-1364 IN denotes in
T3458 1350-1361 NN denotes necroptosis
T3457 1340-1349 VB denotes prevented
T3456 1334-1339 NN denotes cells
T3455 1329-1333 NN denotes L929
T3454 1326-1328 IN denotes of
T3453 1315-1325 NN denotes starvation
T3452 1309-1314 NN denotes serum
T3451 1304-1308 IN denotes that
T3450 1298-1303 VB denotes found
T3449 1295-1297 PRP denotes we
T3448 1293-1294 -COMMA- denotes ,
T3447 1292-1293 -RRB- denotes ]
T3446 1290-1292 CD denotes 16
T3445 1289-1290 -LRB- denotes [
T3444 1282-1288 NN denotes report
T3443 1273-1281 JJ denotes previous
T3442 1271-1272 DT denotes a
T3441 1266-1270 IN denotes with
T3440 1255-1265 JJ denotes Consistent
T3439 1248-1253 NN denotes cells
T3438 1243-1247 NN denotes L929
T3437 1240-1242 IN denotes in
T3436 1232-1239 VB denotes removed
T3435 1229-1231 VB denotes is
T3434 1227-1228 -COMMA- denotes ,
T3219 0-5 JJ denotes Basic
R2033 T3237 T3248 arg1Of undergo,","
R2034 T3237 T3249 arg1Of undergo,[
R2042 T3246 T3245 arg2Of 10,[
R2043 T3247 T3245 arg3Of ],[
R2044 T3250 T3249 arg2Of 17,[
R2045 T3251 T3249 arg3Of ],[
R2046 T3253 T3252 arg2Of addition,In
R2047 T3255 T3256 arg1Of inhibition,of
R2048 T3255 T3274 arg1Of inhibition,is
R2049 T3255 T3275 arg1Of inhibition,sufficient
R2050 T3255 T3277 arg1Of inhibition,trigger
R2051 T3258 T3256 arg2Of activity,of
R2052 T3258 T3257 arg1Of activity,caspase-8
R2053 T3258 T3259 arg1Of activity,alone
R2054 T3262 T3265 arg1Of through,or
R2055 T3264 T3262 arg2Of knockdown,through
R2056 T3264 T3263 arg1Of knockdown,siRNA
R2057 T3265 T3261 arg1Of or,either
R2058 T3266 T3265 arg2Of by,or
R2059 T3267 T3266 arg2Of using,by
R2060 T3270 T3267 arg2Of inhibitor,using
R2061 T3270 T3268 arg1Of inhibitor,the
R2062 T3270 T3269 arg1Of inhibitor,pan-caspase
R2063 T3270 T3271 arg1Of inhibitor,","
R2064 T3272 T3271 arg2Of zVAD.fmk,","
R2065 T3274 T3252 arg1Of is,In
R2066 T3274 T3254 arg1Of is,","
R2067 T3274 T3260 arg1Of is,","
R2068 T3274 T3262 arg1Of is,through
R2069 T3274 T3266 arg1Of is,by
R2070 T3274 T3273 arg1Of is,","
R2071 T3275 T3274 arg2Of sufficient,is
R2072 T3277 T3275 arg2Of trigger,sufficient
R2073 T3277 T3276 arg1Of trigger,to
R2074 T3277 T3279 arg1Of trigger,in
R2075 T3277 T3282 arg1Of trigger,[
R2076 T3277 T3285 arg1Of trigger,","
R2077 T3277 T3286 arg1Of trigger,[
R2078 T3278 T3277 arg2Of necroptosis,trigger
R2079 T3281 T3279 arg2Of cells,in
R2080 T3281 T3280 arg1Of cells,these
R2081 T3283 T3282 arg2Of 10,[
R2082 T3284 T3282 arg3Of ],[
R2083 T3287 T3286 arg2Of 14,[
R2084 T3288 T3286 arg3Of ],[
R2085 T3292 T3293 arg1Of necroptosis,was
R2086 T3292 T3295 arg2Of necroptosis,identified
R2087 T3295 T3291 arg2Of identified,while
R2088 T3295 T3293 arg2Of identified,was
R2089 T3295 T3294 arg1Of identified,initially
R2090 T3295 T3296 arg1Of identified,as
R2091 T3299 T3296 arg2Of form,as
R2092 T3299 T3297 arg1Of form,a
R2093 T3299 T3298 arg1Of form,back-up
R2094 T3299 T3300 arg1Of form,of
R2095 T3302 T3300 arg2Of death,of
R2096 T3302 T3301 arg1Of death,cell
R2097 T3302 T3303 arg2Of death,triggered
R2098 T3306 T3303 arg1Of stimuli,triggered
R2099 T3306 T3304 arg2Of stimuli,by
R2100 T3306 T3305 arg1Of stimuli,pro-apoptotic
R2101 T3306 T3307 arg1Of stimuli,in
R2102 T3309 T3307 arg2Of presence,in
R2103 T3309 T3308 arg1Of presence,the
R2104 T3309 T3310 arg1Of presence,of
R2105 T3312 T3310 arg2Of inhibitors,of
R2106 T3312 T3311 arg1Of inhibitors,apoptosis
R2107 T3312 T3313 arg1Of inhibitors,[
R2108 T3314 T3313 arg2Of 17,[
R2109 T3315 T3313 arg3Of ],[
R2110 T3318 T3317 arg1Of analysis,recent
R2111 T3318 T3319 arg1Of analysis,of
R2112 T3318 T3323 arg1Of analysis,during
R2113 T3318 T3326 arg1Of analysis,has
R2114 T3318 T3327 arg1Of analysis,suggested
R2115 T3322 T3319 arg2Of death,of
R2116 T3322 T3320 arg1Of death,physiological
R2117 T3322 T3321 arg1Of death,cell
R2118 T3325 T3323 arg2Of development,during
R2119 T3325 T3324 arg1Of development,mouse
R2120 T3327 T3289 arg1Of suggested,Interestingly
R2121 T3327 T3290 arg1Of suggested,","
R2122 T3327 T3291 arg1Of suggested,while
R2123 T3327 T3316 arg1Of suggested,","
R2124 T3327 T3326 arg2Of suggested,has
R2125 T3330 T3329 arg1Of loss,the
R2126 T3330 T3331 arg1Of loss,of
R2127 T3330 T3352 arg1Of loss,leads
R2128 T3333 T3331 arg2Of regulators,of
R2129 T3333 T3332 arg1Of regulators,apoptotic
R2130 T3333 T3334 arg1Of regulators,","
R2131 T3333 T3336 arg1Of regulators,as
R2132 T3333 T3343 arg1Of regulators,","
R2133 T3333 T3344 arg1Of regulators,[
R2134 T3333 T3347 arg1Of regulators,","
R2135 T3333 T3348 arg1Of regulators,[
R2136 T3336 T3335 arg1Of as,such
R2137 T3337 T3338 arg1Of caspase-8,and
R2138 T3338 T3336 arg2Of and,as
R2139 T3339 T3338 arg2Of FADD,and
R2140 T3339 T3340 arg1Of FADD,[
R2141 T3341 T3340 arg2Of 18,[
R2142 T3342 T3340 arg3Of ],[
R2143 T3345 T3344 arg2Of 19,[
R2144 T3346 T3344 arg3Of ],[
R2145 T3349 T3348 arg2Of 20,[
R2146 T3350 T3348 arg3Of ],[
R2147 T3352 T3327 arg2Of leads,suggested
R2148 T3352 T3328 arg1Of leads,that
R2149 T3352 T3351 arg1Of leads,","
R2150 T3352 T3353 arg1Of leads,to
R2151 T3352 T3364 arg1Of leads,though
R2152 T3355 T3354 arg1Of induction,robust
R2153 T3355 T3356 arg1Of induction,of
R2154 T3355 T3358 arg1Of induction,and
R2155 T3357 T3356 arg2Of necroptosis,of
R2156 T3358 T3353 arg2Of and,to
R2157 T3359 T3358 arg2Of death,and
R2158 T3359 T3360 arg1Of death,of
R2159 T3362 T3360 arg2Of embryos,of
R2160 T3362 T3361 arg1Of embryos,E10.5
R2161 T3364 T3363 arg1Of though,even
R2162 T3365 T3366 arg1Of apoptosis,is
R2163 T3365 T3369 arg2Of apoptosis,induced
R2164 T3369 T3364 arg2Of induced,though
R2165 T3369 T3366 arg2Of induced,is
R2166 T3369 T3367 arg1Of induced,not
R2167 T3369 T3368 arg1Of induced,normally
R2168 T3369 T3370 arg1Of induced,in
R2169 T3373 T3370 arg2Of embryos,in
R2170 T3373 T3371 arg1Of embryos,wild
R2171 T3373 T3372 arg1Of embryos,type
R2172 T3375 T3374 arg1Of data,These
R2173 T3375 T3376 arg1Of data,are
R2174 T3375 T3377 arg1Of data,reminiscent
R2175 T3375 T3435 arg1Of data,is
R2176 T3375 T3436 arg2Of data,removed
R2177 T3376 T3434 arg1Of are,","
R2178 T3377 T3376 arg2Of reminiscent,are
R2179 T3377 T3378 arg1Of reminiscent,of
R2180 T3380 T3378 arg2Of observations,of
R2181 T3380 T3379 arg1Of observations,the
R2182 T3380 T3381 arg1Of observations,in
R2183 T3383 T3381 arg2Of cells,in
R2184 T3383 T3382 arg1Of cells,L929
R2185 T3383 T3384 arg1Of cells,where
R2186 T3383 T3409 arg1Of cells,that
R2187 T3383 T3410 arg1Of cells,promote
R2188 T3386 T3385 arg1Of loss,the
R2189 T3386 T3387 arg1Of loss,of
R2190 T3386 T3390 arg1Of loss,in
R2191 T3386 T3393 arg1Of loss,is
R2192 T3386 T3394 arg1Of loss,sufficient
R2193 T3389 T3387 arg2Of activity,of
R2194 T3389 T3388 arg1Of activity,caspase
R2195 T3392 T3390 arg2Of cells,in
R2196 T3392 T3391 arg1Of cells,healthy
R2197 T3393 T3384 arg2Of is,where
R2198 T3394 T3393 arg2Of sufficient,is
R2199 T3396 T3398 arg1Of trigger,and
R2200 T3397 T3396 arg2Of necroptosis,trigger
R2201 T3398 T3394 arg2Of and,sufficient
R2202 T3398 T3395 arg1Of and,to
R2203 T3399 T3398 arg2Of prompted,and
R2204 T3400 T3399 arg2Of us,prompted
R2205 T3400 T3402 arg1Of us,explore
R2206 T3402 T3399 arg3Of explore,prompted
R2207 T3402 T3401 arg1Of explore,to
R2208 T3404 T3405 arg1Of extrinsic,or
R2209 T3406 T3405 arg2Of intrinsic,or
R2210 T3408 T3402 arg2Of factors,explore
R2211 T3408 T3403 arg1Of factors,the
R2212 T3408 T3404 arg1Of factors,extrinsic
R2213 T3408 T3406 arg1Of factors,intrinsic
R2214 T3408 T3407 arg1Of factors,cellular
R2215 T3414 T3410 arg2Of activity,promote
R2216 T3414 T3411 arg1Of activity,necroptosis
R2217 T3414 T3412 arg1Of activity,once
R2218 T3414 T3413 arg1Of activity,caspase-8
R2219 T3414 T3415 arg1Of activity,","
R2220 T3414 T3416 arg1Of activity,which
R2221 T3414 T3417 arg1Of activity,cleaves
R2222 T3414 T3419 arg1Of activity,inactivates
R2223 T3417 T3418 arg1Of cleaves,and
R2224 T3418 T3430 arg1Of and,","
R2225 T3418 T3431 arg1Of and,[
R2226 T3419 T3418 arg2Of inactivates,and
R2227 T3421 T3420 arg1Of kinase,RIP1
R2228 T3421 T3422 arg1Of kinase,and
R2229 T3422 T3417 arg2Of and,cleaves
R2230 T3422 T3419 arg2Of and,inactivates
R2231 T3426 T3422 arg2Of CYLD,and
R2232 T3426 T3423 arg1Of CYLD,the
R2233 T3426 T3424 arg1Of CYLD,RIP1
R2234 T3426 T3425 arg1Of CYLD,deubiquitinase
R2235 T3426 T3427 arg1Of CYLD,[
R2236 T3428 T3427 arg2Of 21,[
R2237 T3429 T3427 arg3Of ],[
R2238 T3432 T3431 arg2Of 22,[
R2239 T3433 T3431 arg3Of ],[
R2240 T3436 T3434 arg2Of removed,","
R2241 T3436 T3435 arg2Of removed,is
R2242 T3436 T3437 arg1Of removed,in
R2243 T3439 T3437 arg2Of cells,in
R2244 T3439 T3438 arg1Of cells,L929
R2245 T3440 T3441 arg1Of Consistent,with
R2246 T3444 T3441 arg2Of report,with
R2247 T3444 T3442 arg1Of report,a
R2248 T3444 T3443 arg1Of report,previous
R2249 T3444 T3445 arg1Of report,[
R2250 T3446 T3445 arg2Of 16,[
R2251 T3447 T3445 arg3Of ],[
R2252 T3449 T3440 arg1Of we,Consistent
R2253 T3449 T3450 arg1Of we,found
R2254 T3450 T3440 modOf found,Consistent
R2255 T3450 T3448 arg1Of found,","
R2256 T3453 T3452 arg1Of starvation,serum
R2257 T3453 T3454 arg1Of starvation,of
R2258 T3453 T3457 arg1Of starvation,prevented
R2259 T3456 T3454 arg2Of cells,of
R2260 T3456 T3455 arg1Of cells,L929
R2261 T3457 T3450 arg2Of prevented,found
R2262 T3457 T3451 arg1Of prevented,that
R2263 T3457 T3459 arg1Of prevented,in
R2264 T3458 T3457 arg2Of necroptosis,prevented
R2265 T3460 T3459 arg2Of response,in
R2266 T3460 T3461 arg1Of response,to
R2267 T3462 T3461 arg2Of zVAD.fmk,to
R2268 T3462 T3463 arg1Of zVAD.fmk,(
R2269 T3465 T3463 arg2Of 1A,(
R2270 T3465 T3464 arg1Of 1A,Fig.
R2271 T3466 T3463 arg3Of ),(
R2272 T3468 T3467 arg1Of addition,The
R2273 T3468 T3469 arg1Of addition,of
R2274 T3468 T3477 arg1Of addition,restored
R2275 T3471 T3469 arg2Of factors,of
R2276 T3471 T3470 arg1Of factors,growth
R2277 T3471 T3472 arg1Of factors,","
R2278 T3471 T3474 arg1Of factors,as
R2279 T3474 T3473 arg1Of as,such
R2280 T3475 T3474 arg2Of bFGF,as
R2281 T3477 T3476 arg1Of restored,","
R2282 T3477 T3481 arg1Of restored,under
R2283 T3479 T3478 arg1Of induced,zVAD.fmk
R2284 T3480 T3477 arg2Of death,restored
R2285 T3480 T3479 arg1Of death,induced
R2286 T3484 T3481 arg2Of conditions,under
R2287 T3484 T3482 arg1Of conditions,serum
R2288 T3484 T3483 arg1Of conditions,free
R2289 T3484 T3485 arg1Of conditions,(
R2290 T3487 T3485 arg2Of 1B,(
R2291 T3487 T3486 arg1Of 1B,Fig.
R2292 T3488 T3485 arg3Of ),(
R2293 T3491 T3492 arg1Of this,does
R2294 T3491 T3494 arg1Of this,reflect
R2295 T3494 T3489 arg1Of reflect,Interestingly
R2296 T3494 T3490 arg1Of reflect,","
R2297 T3494 T3492 arg2Of reflect,does
R2298 T3494 T3493 arg1Of reflect,not
R2299 T3494 T3502 arg1Of reflect,","
R2300 T3494 T3503 arg1Of reflect,as
R2301 T3497 T3494 arg2Of requirement,reflect
R2302 T3497 T3495 arg1Of requirement,a
R2303 T3497 T3496 arg1Of requirement,generic
R2304 T3497 T3498 arg1Of requirement,for
R2305 T3501 T3498 arg2Of signaling,for
R2306 T3501 T3499 arg1Of signaling,growth
R2307 T3501 T3500 arg1Of signaling,factor
R2308 T3507 T3504 arg1Of factors,only
R2309 T3507 T3505 arg1Of factors,some
R2310 T3507 T3506 arg1Of factors,growth
R2311 T3507 T3508 arg1Of factors,(
R2312 T3507 T3519 arg1Of factors,promoted
R2313 T3509 T3510 arg1Of bFGF,and
R2314 T3510 T3513 arg1Of and,but
R2315 T3511 T3510 arg2Of IGF-1,and
R2316 T3513 T3508 arg2Of but,(
R2317 T3513 T3512 arg1Of but,","
R2318 T3513 T3514 arg1Of but,not
R2319 T3515 T3516 arg1Of EGF,and
R2320 T3516 T3513 arg2Of and,but
R2321 T3517 T3516 arg2Of PDGF,and
R2322 T3518 T3508 arg3Of ),(
R2323 T3519 T3503 arg2Of promoted,as
R2324 T3520 T3519 arg2Of death,promoted
R2325 T3520 T3521 arg1Of death,(
R2326 T3523 T3521 arg2Of 1B,(
R2327 T3523 T3522 arg1Of 1B,Fig.
R2328 T3524 T3521 arg3Of ),(
R2329 T3529 T3527 arg1Of necroptosis,growth
R2330 T3529 T3528 arg1Of necroptosis,factor-dependent
R2331 T3529 T3530 arg1Of necroptosis,required
R2332 T3530 T3525 arg1Of required,Furthermore
R2333 T3530 T3526 arg1Of required,","
R2334 T3530 T3536 arg1Of required,","
R2335 T3530 T3537 arg1Of required,as
R2336 T3532 T3530 arg2Of inhibition,required
R2337 T3532 T3531 arg1Of inhibition,the
R2338 T3532 T3533 arg1Of inhibition,of
R2339 T3535 T3533 arg2Of activity,of
R2340 T3535 T3534 arg1Of activity,caspase
R2341 T3538 T3539 arg1Of bFGF,alone
R2342 T3538 T3540 arg1Of bFGF,did
R2343 T3538 T3542 arg1Of bFGF,induce
R2344 T3542 T3537 arg2Of induce,as
R2345 T3542 T3540 arg2Of induce,did
R2346 T3542 T3541 arg1Of induce,not
R2347 T3544 T3542 arg2Of death,induce
R2348 T3544 T3543 arg1Of death,cell
R2349 T3544 T3545 arg1Of death,(
R2350 T3547 T3545 arg2Of 1C,(
R2351 T3547 T3546 arg1Of 1C,Fig.
R2352 T3548 T3545 arg3Of ),(
R2353 T3550 T3549 arg2Of contrast,In
R2354 T3552 T3553 arg1Of TNFα,triggered
R2355 T3553 T3549 arg1Of triggered,In
R2356 T3553 T3551 arg1Of triggered,","
R2357 T3553 T3556 arg1Of triggered,efficiently
R2358 T3553 T3557 arg1Of triggered,in
R2359 T3553 T3566 arg1Of triggered,","
R2360 T3553 T3567 modOf triggered,suggesting
R2361 T3554 T3553 arg2Of necroptosis,triggered
R2362 T3556 T3555 arg1Of efficiently,equally
R2363 T3559 T3557 arg2Of absence,in
R2364 T3559 T3558 arg1Of absence,the
R2365 T3559 T3560 arg1Of absence,of
R2366 T3561 T3560 arg2Of serum,of
R2367 T3561 T3562 arg1Of serum,(
R2368 T3564 T3562 arg2Of 1A,(
R2369 T3564 T3563 arg1Of 1A,Fig.
R2370 T3565 T3562 arg3Of ),(
R2371 T3571 T3570 arg1Of factors,growth
R2372 T3571 T3572 arg1Of factors,and
R2373 T3572 T3569 arg1Of and,either
R2374 T3572 T3576 arg1Of and,are
R2375 T3572 T3577 arg2Of and,required
R2376 T3573 T3574 arg1Of zVAD.fmk,or
R2377 T3574 T3572 arg2Of or,and
R2378 T3575 T3574 arg2Of TNFα,or
R2379 T3577 T3567 arg2Of required,suggesting
R2380 T3577 T3568 arg1Of required,that
R2381 T3577 T3576 arg2Of required,are
R2382 T3577 T3578 arg1Of required,for
R2383 T3580 T3578 arg2Of death,for
R2384 T3580 T3579 arg1Of death,necroptotic
R2385 T3580 T3581 arg1Of death,in
R2386 T3583 T3581 arg2Of cells,in
R2387 T3583 T3582 arg1Of cells,L929
R2388 T3585 T3586 arg1Of we,described
R2389 T3586 T3584 arg1Of described,Previously
R2390 T3586 T3594 arg1Of described,as
R2391 T3586 T3612 arg1Of described,","
R2392 T3586 T3613 arg1Of described,[
R2393 T3588 T3586 arg2Of development,described
R2394 T3588 T3587 arg1Of development,the
R2395 T3588 T3589 arg1Of development,of
R2396 T3590 T3589 arg2Of 7-Cl-O-Nec-1,of
R2397 T3590 T3591 arg1Of 7-Cl-O-Nec-1,(
R2398 T3592 T3591 arg2Of Nec-1,(
R2399 T3593 T3591 arg3Of ),(
R2400 T3596 T3597 arg1Of potent,and
R2401 T3598 T3597 arg2Of selective,and
R2402 T3599 T3594 arg2Of inhibitor,as
R2403 T3599 T3595 arg1Of inhibitor,a
R2404 T3599 T3596 arg1Of inhibitor,potent
R2405 T3599 T3598 arg1Of inhibitor,selective
R2406 T3599 T3600 arg1Of inhibitor,of
R2407 T3602 T3601 arg1Of kinase,RIP1
R2408 T3602 T3603 arg1Of kinase,and
R2409 T3603 T3600 arg2Of and,of
R2410 T3604 T3603 arg2Of necroptosis,and
R2411 T3604 T3605 arg1Of necroptosis,(
R2412 T3604 T3609 arg1Of necroptosis,[
R2413 T3607 T3605 arg2Of S1A,(
R2414 T3607 T3606 arg1Of S1A,Fig.
R2415 T3608 T3605 arg3Of ),(
R2416 T3610 T3609 arg2Of 23,[
R2417 T3611 T3609 arg3Of ],[
R2418 T3614 T3613 arg2Of 24,[
R2419 T3615 T3613 arg3Of ],[
R2420 T3619 T3618 arg1Of selectivity,its
R2421 T3619 T3620 arg1Of selectivity,has
R2422 T3619 T3621 arg1Of selectivity,been
R2423 T3619 T3623 arg2Of selectivity,validated
R2424 T3623 T3616 arg1Of validated,Recently
R2425 T3623 T3617 arg1Of validated,","
R2426 T3623 T3620 arg2Of validated,has
R2427 T3623 T3621 arg2Of validated,been
R2428 T3623 T3622 arg1Of validated,further
R2429 T3623 T3624 arg1Of validated,against
R2430 T3626 T3624 arg2Of panel,against
R2431 T3626 T3625 arg1Of panel,a
R2432 T3626 T3627 arg1Of panel,of
R2433 T3628 T3629 arg1Of more,than
R2434 T3630 T3629 arg2Of 400,than
R2435 T3632 T3627 arg2Of kinases,of
R2436 T3632 T3628 arg1Of kinases,more
R2437 T3632 T3631 arg1Of kinases,human
R2438 T3632 T3633 arg1Of kinases,[
R2439 T3634 T3633 arg2Of 15,[
R2440 T3635 T3633 arg3Of ],[
R2441 T3637 T3636 arg1Of inhibitor,This
R2442 T3637 T3639 arg1Of inhibitor,blocked
R2443 T3639 T3638 arg1Of blocked,efficiently
R2444 T3639 T3643 arg1Of blocked,under
R2445 T3642 T3639 arg2Of necroptosis,blocked
R2446 T3642 T3640 arg1Of necroptosis,growth
R2447 T3642 T3641 arg1Of necroptosis,factor/zVAD.fmk-induced
R2448 T3646 T3644 arg1Of conditions,serum
R2449 T3646 T3645 arg1Of conditions,free
R2450 T3646 T3647 arg1Of conditions,in
R2451 T3646 T3650 arg1Of conditions,and
R2452 T3649 T3647 arg2Of cells,in
R2453 T3649 T3648 arg1Of cells,L929
R2454 T3650 T3643 arg2Of and,under
R2455 T3652 T3653 arg1Of zVAD.fmk,and
R2456 T3653 T3650 arg2Of and,and
R2457 T3653 T3651 arg1Of and,both
R2458 T3653 T3656 arg1Of and,under
R2459 T3655 T3653 arg2Of necroptosis,and
R2460 T3655 T3654 arg1Of necroptosis,TNFα-induced
R2461 T3659 T3656 arg2Of conditions,under
R2462 T3659 T3657 arg1Of conditions,full
R2463 T3659 T3658 arg1Of conditions,serum
R2464 T3659 T3660 arg1Of conditions,(
R2465 T3662 T3660 arg2Of 1B,(
R2466 T3662 T3661 arg1Of 1B,Fig.
R2467 T3662 T3663 arg1Of 1B,","
R2468 T3664 T3663 arg2Of S1B,","
R2469 T3665 T3660 arg3Of ),(
R2470 T3668 T3666 arg1Of validate,To
R2471 T3668 T3667 arg1Of validate,further
R2472 T3670 T3668 arg2Of role,validate
R2473 T3670 T3669 arg1Of role,the
R2474 T3670 T3671 arg1Of role,of
R2475 T3672 T3671 arg2Of RIP1,of
R2476 T3674 T3668 arg1Of we,validate
R2477 T3674 T3675 arg1Of we,used
R2478 T3675 T3666 modOf used,To
R2479 T3675 T3673 arg1Of used,","
R2480 T3678 T3675 arg2Of analog,used
R2481 T3678 T3676 arg1Of analog,an
R2482 T3678 T3677 arg1Of analog,inactive
R2483 T3678 T3679 arg1Of analog,","
R2484 T3680 T3679 arg2Of 7-Cl-O-Nec-1i,","
R2485 T3680 T3681 arg1Of 7-Cl-O-Nec-1i,(
R2486 T3680 T3684 arg1Of 7-Cl-O-Nec-1i,(
R2487 T3680 T3688 arg1Of 7-Cl-O-Nec-1i,","
R2488 T3680 T3689 arg1Of 7-Cl-O-Nec-1i,which
R2489 T3680 T3690 arg1Of 7-Cl-O-Nec-1i,contains
R2490 T3682 T3681 arg2Of Nec-1i,(
R2491 T3683 T3681 arg3Of ),(
R2492 T3686 T3684 arg2Of S1A,(
R2493 T3686 T3685 arg1Of S1A,Fig.
R2494 T3687 T3684 arg3Of ),(
R2495 T3694 T3690 arg2Of group,contains
R2496 T3694 T3691 arg1Of group,an
R2497 T3694 T3692 arg1Of group,extra
R2498 T3694 T3693 arg1Of group,N-methyl
R2499 T3694 T3695 arg1Of group,that
R2500 T3694 T3696 arg1Of group,leads
R2501 T3696 T3697 arg1Of leads,to
R2502 T3696 T3708 arg1Of leads,[
R2503 T3699 T3698 arg1Of complete,almost
R2504 T3700 T3697 arg2Of loss,to
R2505 T3700 T3699 arg1Of loss,complete
R2506 T3700 T3701 arg1Of loss,of
R2507 T3700 T3707 arg1Of loss,vitro
R2508 T3705 T3701 arg2Of activity,of
R2509 T3705 T3702 arg1Of activity,RIP1
R2510 T3705 T3703 arg1Of activity,kinase
R2511 T3705 T3704 arg1Of activity,inhibitory
R2512 T3707 T3706 arg1Of vitro,in
R2513 T3709 T3708 arg2Of 23,[
R2514 T3710 T3708 arg3Of ],[
R2515 T3711 T3712 arg1Of Nec-1i,was
R2516 T3711 T3713 arg1Of Nec-1i,unable
R2517 T3711 T3715 arg1Of Nec-1i,protect
R2518 T3713 T3712 arg2Of unable,was
R2519 T3715 T3713 arg2Of protect,unable
R2520 T3715 T3714 arg1Of protect,to
R2521 T3715 T3719 arg1Of protect,under
R2522 T3718 T3715 arg2Of death,protect
R2523 T3718 T3716 arg1Of death,L929
R2524 T3718 T3717 arg1Of death,cell
R2525 T3721 T3720 arg1Of condtions,serum
R2526 T3721 T3722 arg2Of condtions,treated
R2527 T3721 T3731 arg1Of condtions,or
R2528 T3722 T3723 arg1Of treated,with
R2529 T3724 T3725 arg1Of zVAD.fmk,or
R2530 T3725 T3723 arg2Of or,with
R2531 T3725 T3727 arg1Of or,(
R2532 T3726 T3725 arg2Of TNFα,or
R2533 T3729 T3727 arg2Of S1B,(
R2534 T3729 T3728 arg1Of S1B,Fig.
R2535 T3730 T3727 arg3Of ),(
R2536 T3731 T3719 arg2Of or,under
R2537 T3734 T3731 arg2Of conditions,or
R2538 T3734 T3732 arg1Of conditions,serum
R2539 T3734 T3733 arg1Of conditions,free
R2540 T3734 T3735 arg2Of conditions,treated
R2541 T3735 T3736 arg1Of treated,with
R2542 T3737 T3736 arg2Of bFGF/zVAD.fmk,with
R2543 T3737 T3738 arg1Of bFGF/zVAD.fmk,(
R2544 T3740 T3738 arg2Of S1C,(
R2545 T3740 T3739 arg1Of S1C,Fig.
R2546 T3741 T3738 arg3Of ),(
R2547 T3742 T3743 arg1Of This,confirms
R2548 T3746 T3745 arg1Of kinase,RIP1
R2549 T3746 T3747 arg1Of kinase,is
R2550 T3746 T3748 arg1Of kinase,responsible
R2551 T3747 T3743 arg2Of is,confirms
R2552 T3747 T3744 arg1Of is,that
R2553 T3748 T3747 arg2Of responsible,is
R2554 T3748 T3749 arg1Of responsible,for
R2555 T3748 T3754 arg1Of responsible,under
R2556 T3750 T3749 arg2Of necroptosis,for
R2557 T3750 T3751 arg1Of necroptosis,in
R2558 T3753 T3751 arg2Of cells,in
R2559 T3753 T3752 arg1Of cells,L929
R2560 T3756 T3757 arg1Of serum,and
R2561 T3757 T3754 arg2Of and,under
R2562 T3757 T3755 arg1Of and,both
R2563 T3760 T3757 arg2Of conditions,and
R2564 T3760 T3758 arg1Of conditions,serum
R2565 T3760 T3759 arg1Of conditions,free
R2566 T3761 T3763 arg1Of We,examined
R2567 T3763 T3762 arg1Of examined,next
R2568 T3765 T3766 arg1Of bFGF,contributes
R2569 T3766 T3763 arg2Of contributes,examined
R2570 T3766 T3764 arg1Of contributes,whether
R2571 T3766 T3767 arg1Of contributes,to
R2572 T3766 T3770 arg1Of contributes,under
R2573 T3769 T3767 arg2Of necroptosis,to
R2574 T3769 T3768 arg1Of necroptosis,zVAD.fmk-induced
R2575 T3773 T3770 arg2Of conditions,under
R2576 T3773 T3771 arg1Of conditions,normal
R2577 T3773 T3772 arg1Of conditions,serum
R2578 T3773 T3774 arg1Of conditions,(
R2579 T3775 T3776 arg1Of 10,%
R2580 T3777 T3774 arg2Of FBS,(
R2581 T3777 T3775 arg1Of FBS,10
R2582 T3778 T3774 arg3Of ),(
R2583 T3779 T3780 arg1Of We,used
R2584 T3779 T3794 arg1Of We,determined
R2585 T3780 T3793 arg1Of used,and
R2586 T3786 T3780 arg2Of inhibitors,used
R2587 T3786 T3781 arg1Of inhibitors,two
R2588 T3786 T3782 arg1Of inhibitors,bFGF
R2589 T3786 T3783 arg1Of inhibitors,receptor
R2590 T3786 T3784 arg1Of inhibitors,tyrosine
R2591 T3786 T3785 arg1Of inhibitors,kinase
R2592 T3786 T3787 arg1Of inhibitors,(
R2593 T3788 T3789 arg1Of PD173074,and
R2594 T3789 T3787 arg2Of and,(
R2595 T3790 T3789 arg2Of PD166866,and
R2596 T3791 T3787 arg3Of ),(
R2597 T3793 T3792 arg1Of and,","
R2598 T3794 T3793 arg2Of determined,and
R2599 T3796 T3797 arg1Of inhibition,of
R2600 T3796 T3801 arg1Of inhibition,inhibited
R2601 T3799 T3797 arg2Of signaling,of
R2602 T3799 T3798 arg1Of signaling,bFGF
R2603 T3801 T3794 arg2Of inhibited,determined
R2604 T3801 T3795 arg1Of inhibited,that
R2605 T3801 T3800 arg1Of inhibited,strongly
R2606 T3801 T3804 arg1Of inhibited,under
R2607 T3803 T3801 arg2Of necroptosis,inhibited
R2608 T3803 T3802 arg1Of necroptosis,zVAD.fmk-induced
R2609 T3807 T3804 arg2Of conditions,under
R2610 T3807 T3805 arg1Of conditions,normal
R2611 T3807 T3806 arg1Of conditions,serum
R2612 T3807 T3808 arg1Of conditions,(
R2613 T3810 T3808 arg2Of 1D,(
R2614 T3810 T3809 arg1Of 1D,Fig.
R2615 T3811 T3808 arg3Of ),(
R2616 T3813 T3812 arg2Of contrast,In
R2617 T3818 T3815 arg1Of inhibitor,neither
R2618 T3818 T3816 arg1Of inhibitor,bFGF
R2619 T3818 T3817 arg1Of inhibitor,receptor
R2620 T3818 T3819 arg1Of inhibitor,was
R2621 T3818 T3820 arg1Of inhibitor,able
R2622 T3818 T3822 arg1Of inhibitor,attenuate
R2623 T3819 T3812 arg1Of was,In
R2624 T3819 T3814 arg1Of was,","
R2625 T3819 T3829 arg1Of was,","
R2626 T3819 T3830 arg1Of was,consistent
R2627 T3819 T3831 arg1Of was,with
R2628 T3820 T3819 arg2Of able,was
R2629 T3822 T3820 arg2Of attenuate,able
R2630 T3822 T3821 arg1Of attenuate,to
R2631 T3824 T3822 arg2Of necroptosis,attenuate
R2632 T3824 T3823 arg1Of necroptosis,TNFα-induced
R2633 T3824 T3825 arg1Of necroptosis,(
R2634 T3827 T3825 arg2Of 1D,(
R2635 T3827 T3826 arg1Of 1D,Fig.
R2636 T3828 T3825 arg3Of ),(
R2637 T3833 T3831 arg2Of factors,with
R2638 T3833 T3832 arg1Of factors,growth
R2639 T3833 T3834 arg1Of factors,being
R2640 T3833 T3835 arg1Of factors,dispensable
R2641 T3834 T3831 arg3Of being,with
R2642 T3835 T3834 arg2Of dispensable,being
R2643 T3835 T3836 arg1Of dispensable,for
R2644 T3838 T3836 arg2Of pathway,for
R2645 T3838 T3837 arg1Of pathway,this
R2646 T3838 T3839 arg1Of pathway,(
R2647 T3841 T3839 arg2Of 1A,(
R2648 T3841 T3840 arg1Of 1A,Fig.
R2649 T3842 T3839 arg3Of ),(
R2650 T3846 T3845 arg1Of data,these
R2651 T3846 T3847 arg1Of data,suggest
R2652 T3847 T3843 arg1Of suggest,Overall
R2653 T3847 T3844 arg1Of suggest,","
R2654 T3850 T3849 arg1Of induction,the
R2655 T3850 T3851 arg1Of induction,of
R2656 T3850 T3853 arg1Of induction,by
R2657 T3850 T3855 arg1Of induction,is
R2658 T3850 T3856 arg2Of induction,promoted
R2659 T3852 T3851 arg2Of necroptosis,of
R2660 T3854 T3853 arg2Of zVAD.fmk,by
R2661 T3856 T3847 arg2Of promoted,suggest
R2662 T3856 T3848 arg1Of promoted,that
R2663 T3856 T3855 arg2Of promoted,is
R2664 T3856 T3859 arg1Of promoted,under
R2665 T3858 T3856 arg1Of bFGF,promoted
R2666 T3858 T3857 arg2Of bFGF,by
R2667 T3861 T3862 arg1Of serum,and
R2668 T3863 T3862 arg2Of serum,and
R2669 T3865 T3859 arg2Of conditions,under
R2670 T3865 T3860 arg1Of conditions,both
R2671 T3865 T3861 arg1Of conditions,serum
R2672 T3865 T3863 arg1Of conditions,serum
R2673 T3865 T3864 arg1Of conditions,free
R2674 T3867 T3866 arg1Of induction,The
R2675 T3867 T3868 arg1Of induction,of
R2676 T3867 T3873 arg1Of induction,is
R2677 T3869 T3868 arg2Of necroptosis,of
R2678 T3873 T3870 arg1Of is,","
R2679 T3873 T3871 arg1Of is,however
R2680 T3873 T3872 arg1Of is,","
R2681 T3873 T3874 arg1Of is,not
R2682 T3873 T3882 arg1Of is,since
R2683 T3877 T3873 arg2Of consequence,is
R2684 T3877 T3875 arg1Of consequence,a
R2685 T3877 T3876 arg1Of consequence,simple
R2686 T3877 T3878 arg1Of consequence,of
R2687 T3881 T3878 arg2Of signaling,of
R2688 T3881 T3879 arg1Of signaling,growth
R2689 T3881 T3880 arg1Of signaling,factor
R2690 T3886 T3883 arg1Of factors,not
R2691 T3886 T3884 arg1Of factors,all
R2692 T3886 T3885 arg1Of factors,growth
R2693 T3886 T3887 arg1Of factors,allowed
R2694 T3887 T3882 arg2Of allowed,since
R2695 T3888 T3887 arg2Of death,allowed
R2696 T3888 T3890 arg1Of death,occur
R2697 T3890 T3887 arg3Of occur,allowed
R2698 T3890 T3889 arg1Of occur,to
R2699 T3895 T3893 arg1Of events,specific
R2700 T3895 T3894 arg1Of events,signaling
R2701 T3895 T3896 arg2Of events,mediated
R2702 T3895 T3901 arg1Of events,appear
R2703 T3895 T3903 arg1Of events,contribute
R2704 T3900 T3896 arg1Of factors,mediated
R2705 T3900 T3897 arg2Of factors,by
R2706 T3900 T3898 arg1Of factors,particular
R2707 T3900 T3899 arg1Of factors,growth
R2708 T3901 T3891 arg1Of appear,Instead
R2709 T3901 T3892 arg1Of appear,","
R2710 T3903 T3901 arg2Of contribute,appear
R2711 T3903 T3902 arg1Of contribute,to
R2712 T3903 T3904 arg1Of contribute,to
R2713 T3906 T3904 arg2Of death,to
R2714 T3906 T3905 arg1Of death,necroptotic
R19754 T28537 T28538 arg1Of bFGF,and
R19755 T28538 T28540 arg1Of and,promote
R19756 T28539 T28538 arg2Of IGF-1,and
R19757 T28540 T28542 arg1Of promote,in
R19758 T28541 T28540 arg2Of necroptosis,promote
R19759 T28542 T28544 arg1Of in,with
R19760 T28543 T28542 arg2Of concert,in
R19761 T28545 T28542 arg3Of zVAD.fmk,in
R19762 T28547 T28546 arg2Of A,(
R19763 T28548 T28546 arg3Of ),(
R19764 T28550 T28546 arg1Of cells,(
R19765 T28550 T28549 arg1Of cells,L929
R19766 T28550 T28551 arg1Of cells,were
R19767 T28550 T28552 arg2Of cells,treated
R19768 T28552 T28551 arg2Of treated,were
R19769 T28552 T28553 arg1Of treated,with
R19790 T28572 T28573 arg1Of determined,after
R19791 T28572 T28576 modOf determined,using
R19792 T28575 T28573 arg2Of hr,after
R19793 T28575 T28574 arg1Of hr,24
R19794 T28580 T28576 arg2Of assay,using
R19795 T28580 T28577 arg1Of assay,the
R19796 T28580 T28578 arg1Of assay,CellTiter-Glo
R19797 T28580 T28579 arg1Of assay,Viability
R19798 T28582 T28581 arg1Of concentrations,The
R19799 T28582 T28583 arg1Of concentrations,of
R19800 T28582 T28587 arg1Of concentrations,are
R19801 T28582 T28588 arg2Of concentrations,listed
R19802 T28586 T28583 arg2Of agents,of
R19803 T28586 T28584 arg1Of agents,all
R19804 T28586 T28585 arg1Of agents,necroptosis-inducing
R19805 T28588 T28587 arg2Of listed,are
R19806 T28588 T28589 arg1Of listed,in
R19807 T28588 T28606 arg1Of listed,with
R19809 T28589 T28590 arg1Of in,the
R19810 T28591 T28592 arg1Of Materials,and
R19811 T28592 T28589 arg2Of and,in
R19812 T28592 T28604 modOf and,were
R19813 T28593 T28592 arg2Of Methods,and
R19814 T28594 T28595 arg1Of section,or
R19815 T28594 T28596 arg2Of section,indicated
R19816 T28594 T28604 arg1Of section,were
R19817 T28594 T28605 arg2Of section,treated
R19818 T28596 T28597 arg1Of indicated,in
R19819 T28601 T28600 arg2Of B,(
R19820 T28602 T28600 arg3Of ),(
R19821 T28603 T28597 arg2Of Cells,in
R19822 T28603 T28598 arg1Of Cells,the
R19823 T28603 T28599 arg1Of Cells,figures.
R19824 T28603 T28600 arg1Of Cells,(
R19825 T28605 T28604 arg2Of treated,were
R19826 T28607 T28606 arg2Of zVAD.fmk,with
R19827 T28607 T28608 arg1Of zVAD.fmk,","
R19834 T28615 T28658 arg1Of Nec-1,was
R19835 T28615 T28659 arg2Of Nec-1,induced
R19859 T28638 T28646 arg1Of treated,for
R19865 T28645 T28644 arg2Of both,or
R19866 T28648 T28646 arg2Of hrs,for
R19867 T28648 T28647 arg1Of hrs,24
R19868 T28648 T28649 arg2Of hrs,followed
R19869 T28652 T28649 arg1Of assay.,followed
R19870 T28652 T28650 arg2Of assay.,by
R19871 T28652 T28651 arg1Of assay.,viability
R19872 T28652 T28653 arg1Of assay.,(
R19873 T28654 T28653 arg2Of D,(
R19874 T28655 T28653 arg3Of ),(
R19877 T28657 T28656 arg1Of death,Cell
R19879 T28659 T28658 arg2Of induced,was
R19880 T28659 T28664 arg1Of induced,under
R19881 T28659 T28668 arg1Of induced,in
R19882 T28661 T28662 arg1Of zVAD.fmk,or
R19883 T28662 T28659 arg1Of or,induced
R19884 T28662 T28660 arg2Of or,by
R19885 T28663 T28662 arg2Of TNFα,or
R19886 T28667 T28664 arg2Of condition,under
R19887 T28667 T28665 arg1Of condition,full
R19888 T28667 T28666 arg1Of condition,serum
R19889 T28668 T28669 arg1Of in,the
R19890 T28668 T28671 arg1Of in,of
R19891 T28670 T28668 arg2Of presence,in
R19892 T28672 T28673 arg1Of 2,µM
R19893 T28674 T28672 arg1Of PD173074,2
R19894 T28674 T28675 arg1Of PD173074,and
R19895 T28675 T28668 arg3Of and,in
R19896 T28678 T28675 arg2Of PD166866,and
R19897 T28678 T28676 arg1Of PD166866,20
R19898 T28678 T28677 arg1Of PD166866,µM
R19899 T28681 T28679 arg2Of graphs,In
R19900 T28681 T28680 arg1Of graphs,all
R19901 T28683 T28684 arg1Of average±SD,was
R19902 T28683 T28685 arg2Of average±SD,plotted
R19903 T28685 T28679 arg1Of plotted,In
R19904 T28685 T28682 arg1Of plotted,","
R19905 T28685 T28684 arg2Of plotted,was
R2013 T3224 T3219 arg1Of Necroptosis,Basic
R2014 T3224 T3220 arg1Of Necroptosis,Fibroblast
R2015 T3224 T3221 arg1Of Necroptosis,Growth
R2016 T3224 T3222 arg1Of Necroptosis,Factor
R2017 T3224 T3223 arg1Of Necroptosis,Promotes
R2018 T3224 T3225 arg1Of Necroptosis,in
R2019 T3227 T3225 arg2Of Cells,in
R2020 T3227 T3226 arg1Of Cells,L929
R2021 T3228 T3229 arg1Of It,has
R2022 T3228 T3230 arg1Of It,been
R2023 T3228 T3231 arg2Of It,established
R2024 T3231 T3229 arg2Of established,has
R2025 T3231 T3230 arg2Of established,been
R2026 T3236 T3233 arg1Of cells,mouse
R2027 T3236 T3234 arg1Of cells,fibrosarcoma
R2028 T3236 T3235 arg1Of cells,L929
R2029 T3236 T3237 arg1Of cells,undergo
R2030 T3237 T3231 arg3Of undergo,established
R2031 T3237 T3232 arg1Of undergo,that
R2032 T3237 T3241 arg1Of undergo,following
R2035 T3240 T3237 arg2Of death,undergo
R2036 T3240 T3238 arg1Of death,necroptotic
R2037 T3240 T3239 arg1Of death,cell
R2038 T3242 T3241 arg2Of stimulation,following
R2039 T3242 T3243 arg1Of stimulation,with
R2040 T3244 T3243 arg2Of TNFα,with
R2041 T3244 T3245 arg1Of TNFα,[
R19770 T28554 T28555 arg1Of TNFα,or
R19771 T28555 T28553 arg2Of or,with
R19772 T28555 T28557 arg1Of or,under
R19773 T28556 T28555 arg2Of zVAD.fmk,or
R19774 T28559 T28558 arg1Of serum,normal
R19775 T28559 T28560 arg1Of serum,(
R19776 T28559 T28565 arg1Of serum,or
R19777 T28561 T28562 arg1Of 10,%
R19778 T28563 T28560 arg2Of FBS,(
R19779 T28563 T28561 arg1Of FBS,10
R19780 T28564 T28560 arg3Of ),(
R19781 T28565 T28557 arg2Of or,under
R19782 T28568 T28565 arg2Of conditions,or
R19783 T28568 T28566 arg1Of conditions,serum
R19784 T28568 T28567 arg1Of conditions,free
R19785 T28570 T28569 arg1Of viability,Cell
R19786 T28570 T28571 arg1Of viability,was
R19787 T28570 T28572 arg2Of viability,determined
R19788 T28570 T28576 arg1Of viability,using
R19789 T28572 T28571 arg2Of determined,was
R19808 T28588 T28614 arg1Of listed,and
R19828 T28612 T28608 arg2Of factors,","
R19829 T28612 T28609 arg1Of factors,the
R19830 T28612 T28610 arg2Of factors,indicated
R19831 T28612 T28611 arg1Of factors,growth
R19832 T28614 T28613 arg1Of and,","
R19833 T28615 T28616 arg1Of Nec-1,under
R19836 T28619 T28616 arg2Of conditions,under
R19837 T28619 T28617 arg1Of conditions,serum
R19838 T28619 T28618 arg1Of conditions,free
R19839 T28619 T28620 arg1Of conditions,for
R19840 T28622 T28620 arg2Of hrs,for
R19841 T28622 T28621 arg1Of hrs,24
R19842 T28622 T28623 arg2Of hrs,followed
R19843 T28625 T28623 arg1Of measurement,followed
R19844 T28625 T28624 arg2Of measurement,by
R19845 T28625 T28626 arg1Of measurement,of
R19846 T28625 T28633 arg1Of measurement,under
R19847 T28628 T28627 arg1Of viability.,cell
R19848 T28628 T28629 arg1Of viability.,(
R19849 T28630 T28629 arg2Of C,(
R19850 T28631 T28629 arg3Of ),(
R19851 T28632 T28626 arg2Of Cells,of
R19852 T28632 T28628 arg1Of Cells,viability.
R19853 T28634 T28637 modOf serum,were
R19854 T28636 T28635 arg1Of conditions,free
R19855 T28636 T28637 arg1Of conditions,were
R19856 T28636 T28638 arg2Of conditions,treated
R19857 T28638 T28637 arg2Of treated,were
R19858 T28638 T28639 arg1Of treated,with
R19860 T28640 T28641 arg1Of FGF,","
R19861 T28641 T28644 arg1Of ",",or
R19862 T28642 T28641 arg2Of zVAD.fmk,","
R19863 T28644 T28639 arg2Of or,with
R19864 T28644 T28643 arg1Of or,","
R19875 T28657 T28633 arg2Of death,under
R19876 T28657 T28634 arg1Of death,serum
R19878 T28659 T28614 arg2Of induced,and

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T3038 1122-1131 Antecedent denotes caspase-8
T3037 1142-1147 Anaphor denotes which
R2012 T3037 T3038 boundBy which,caspase-8

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T3065 4255-4268 Protein denotes bFGF receptor
T3064 4130-4134 Protein denotes bFGF
T3063 4030-4059 Protein denotes bFGF receptor tyrosine kinase
T3062 3928-3932 Protein denotes bFGF
T3061 3802-3806 Protein denotes RIP1
T3060 3757-3761 Protein denotes bFGF
T3059 3703-3707 Protein denotes TNFα
T3058 3564-3568 Protein denotes RIP1
T3057 3418-3422 Protein denotes RIP1
T3056 3317-3321 Protein denotes TNFα
T3055 3018-3022 Protein denotes RIP1
T3054 1989-1993 Protein denotes TNFα
T3053 1853-1857 Protein denotes TNFα
T3052 1792-1796 Protein denotes bFGF
T3051 1655-1658 Protein denotes EGF
T3050 1640-1645 Protein denotes IGF-1
T3049 1631-1635 Protein denotes bFGF
T3048 1437-1441 Protein denotes bFGF
T3047 1212-1216 Protein denotes CYLD
T3046 1192-1211 Protein denotes RIP1 deubiquitinase
T3045 1172-1176 Protein denotes RIP1
T3044 1122-1131 Protein denotes caspase-8
T3043 712-716 Protein denotes FADD
T3042 698-707 Protein denotes caspase-8
T3041 227-236 Protein denotes caspase-8
T3040 183-187 Protein denotes TNFα
T3039 0-30 Protein denotes Basic Fibroblast Growth Factor
T3067 4503-4507 Protein denotes bFGF
T3066 4301-4305 Protein denotes TNFα
T28516 2791-2795 Protein denotes TNFα
T28515 2182-2186 Protein denotes TNFα
T28514 2097-2102 Protein denotes IGF-1
T28513 2088-2092 Protein denotes bFGF

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T28693 2791-2795 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T28692 2182-2186 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T28691 2686-2689 http://www.uniprot.org/uniprot/Q788Q8 denotes FGF
T28690 2088-2092 http://www.uniprot.org/uniprot/Q788Q8 denotes bFGF
T3973 4503-4507 http://www.uniprot.org/uniprot/Q788Q8 denotes bFGF
T3954 1853-1857 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T3953 183-187 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T3972 4255-4259 http://www.uniprot.org/uniprot/Q788Q8 denotes bFGF
T3971 4130-4134 http://www.uniprot.org/uniprot/Q788Q8 denotes bFGF
T3970 4030-4034 http://www.uniprot.org/uniprot/Q788Q8 denotes bFGF
T3969 3928-3932 http://www.uniprot.org/uniprot/Q788Q8 denotes bFGF
T3968 3757-3761 http://www.uniprot.org/uniprot/Q788Q8 denotes bFGF
T3967 1792-1796 http://www.uniprot.org/uniprot/Q788Q8 denotes bFGF
T3966 1631-1635 http://www.uniprot.org/uniprot/Q788Q8 denotes bFGF
T3965 1437-1441 http://www.uniprot.org/uniprot/Q788Q8 denotes bFGF
T3964 3802-3806 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T3963 3564-3568 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T3962 3418-3422 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T3961 3018-3022 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T3960 1192-1196 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T3959 1172-1176 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T3958 4301-4305 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T3957 3703-3707 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T3956 3317-3321 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T3955 1989-1993 http://www.uniprot.org/uniprot/P01375 denotes TNFα

UBERON-AE

Id Subject Object Predicate Lexical cue
T28503 2807-2812 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T28502 2646-2651 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T28501 2554-2559 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T28500 2231-2236 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T28499 2212-2217 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2971 4529-4534 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2970 4519-4524 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2969 4206-4211 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2968 3990-3995 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2967 3880-3885 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2966 3870-3875 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2965 3722-3727 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2964 3662-3667 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2963 3353-3358 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2962 3259-3264 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2961 1918-1923 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2960 1481-1486 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2959 1309-1314 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T2958 862-869 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos
T2957 795-802 http://purl.obolibrary.org/obo/UBERON_0000922 denotes embryos

GO-BP

Id Subject Object Predicate Lexical cue
T28525 2758-2763 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T28524 2753-2775 http://purl.obolibrary.org/obo/GO_0071888 denotes Cell death was induced
T28523 2753-2775 http://purl.obolibrary.org/obo/GO_0043276 denotes Cell death was induced
T28522 2753-2763 http://purl.obolibrary.org/obo/GO_0008219 denotes Cell death
T28521 2522-2528 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T28520 2363-2374 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T28519 2111-2122 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T28518 2363-2374 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T28517 2111-2122 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3153 4053-4070 http://purl.obolibrary.org/obo/GO_0033673 denotes kinase inhibitors
T3152 4035-4059 http://purl.obolibrary.org/obo/GO_0038083 denotes receptor tyrosine kinase
T3151 1757-1787 http://purl.obolibrary.org/obo/GO_0097340 denotes inhibition of caspase activity
T3150 1757-1787 http://purl.obolibrary.org/obo/GO_0043154 denotes inhibition of caspase activity
T3149 4717-4726 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T3148 4636-4645 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T3147 4135-4144 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T3146 1591-1600 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T3145 1197-1211 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinase
T3144 1075-1083 http://purl.obolibrary.org/obo/GO_0007349 denotes cellular
T3143 1771-1787 http://purl.obolibrary.org/obo/GO_0097153 denotes caspase activity
T3142 950-966 http://purl.obolibrary.org/obo/GO_0097153 denotes caspase activity
T3141 1771-1787 http://purl.obolibrary.org/obo/GO_0004197 denotes caspase activity
T3140 950-966 http://purl.obolibrary.org/obo/GO_0004197 denotes caspase activity
T3139 2943-2954 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T3138 625-636 http://purl.obolibrary.org/obo/GO_0032502 denotes development
T3137 587-605 http://purl.obolibrary.org/obo/GO_0009987 denotes physiological cell
T3136 815-824 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T3135 541-550 http://purl.obolibrary.org/obo/GO_0097194 denotes apoptosis
T3134 815-824 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T3133 541-550 http://purl.obolibrary.org/obo/GO_0006915 denotes apoptosis
T3132 4808-4813 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3131 4683-4688 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3130 3650-3655 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3129 2023-2028 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3128 1823-1828 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3127 1678-1683 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3126 1469-1474 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3125 780-785 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3124 606-611 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3123 481-486 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3122 150-155 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T3121 3645-3655 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3120 1818-1828 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3119 601-611 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3118 476-486 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3117 145-155 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T3116 4569-4580 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3115 4464-4475 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3114 4314-4325 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3113 4181-4192 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3112 3965-3976 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3111 3833-3844 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3110 3330-3341 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3109 3241-3252 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3108 3034-3045 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3107 1868-1879 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3106 1732-1743 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3105 1350-1361 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3104 1105-1116 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3103 1009-1020 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3102 764-775 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3101 418-429 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3100 358-369 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T3099 40-51 http://purl.obolibrary.org/obo/GO_0097528 denotes Necroptosis
T3098 4556-4580 http://purl.obolibrary.org/obo/GO_0070266 denotes induction of necroptosis
T3097 4451-4475 http://purl.obolibrary.org/obo/GO_0070266 denotes induction of necroptosis
T3096 751-775 http://purl.obolibrary.org/obo/GO_0070266 denotes induction of necroptosis
T3095 4464-4475 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3094 4314-4325 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3093 4181-4192 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3092 3965-3976 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3091 3833-3844 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3090 3330-3341 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3089 3241-3252 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3088 3034-3045 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3087 1868-1879 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3086 1732-1743 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3085 1350-1361 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3084 1105-1116 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3083 1009-1020 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3082 764-775 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3081 418-429 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3080 358-369 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T3079 40-51 http://purl.obolibrary.org/obo/GO_0070266 denotes Necroptosis
T3078 4757-4763 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3077 4660-4666 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3076 4622-4628 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3075 4353-4359 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3074 3210-3216 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3073 1958-1964 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3072 1708-1714 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3071 1615-1621 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3070 1577-1583 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3069 1413-1419 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T3068 17-23 http://purl.obolibrary.org/obo/GO_0040007 denotes Growth

GO-MF

Id Subject Object Predicate Lexical cue
T3161 4035-4059 http://purl.obolibrary.org/obo/GO_0030971 denotes receptor tyrosine kinase
T3160 1663-1667 http://purl.obolibrary.org/obo/GO_0005161 denotes PDGF
T3159 1655-1658 http://purl.obolibrary.org/obo/GO_0005154 denotes EGF
T3158 1197-1211 http://purl.obolibrary.org/obo/GO_0004843 denotes deubiquitinase
T3157 1771-1787 http://purl.obolibrary.org/obo/GO_0097153 denotes caspase activity
T3156 950-966 http://purl.obolibrary.org/obo/GO_0097153 denotes caspase activity
T3155 1771-1787 http://purl.obolibrary.org/obo/GO_0004197 denotes caspase activity
T3154 950-966 http://purl.obolibrary.org/obo/GO_0004197 denotes caspase activity

GO-CC

Id Subject Object Predicate Lexical cue
T28528 2753-2757 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T28527 2254-2258 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T28526 2158-2163 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3170 3853-3858 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3169 3289-3294 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3168 2037-2042 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3167 1334-1339 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3166 1248-1253 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3165 978-983 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3164 926-931 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3163 379-384 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3162 119-124 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T28508 2876-2914 Sentence denotes In all graphs, average±SD was plotted.
T28507 2337-2875 Sentence denotes The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866.
T28506 2254-2336 Sentence denotes Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay.
T28505 2149-2253 Sentence denotes (A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions.
T28504 2088-2148 Sentence denotes bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.
T2993 4699-4814 Sentence denotes Instead, specific signaling events mediated by particular growth factors appear to contribute to necroptotic death.
T2992 4552-4698 Sentence denotes The induction of necroptosis, however, is not a simple consequence of growth factor signaling since not all growth factors allowed death to occur.
T2991 4414-4551 Sentence denotes Overall, these data suggest that the induction of necroptosis by zVAD.fmk is promoted by bFGF under both serum and serum free conditions.
T2990 4234-4413 Sentence denotes In contrast, neither bFGF receptor inhibitor was able to attenuate TNFα-induced necroptosis (Fig. 1D), consistent with growth factors being dispensable for this pathway (Fig. 1A).
T2989 4018-4233 Sentence denotes We used two bFGF receptor tyrosine kinase inhibitors (PD173074 and PD166866), and determined that inhibition of bFGF signaling strongly inhibited zVAD.fmk-induced necroptosis under normal serum conditions (Fig. 1D).
T2988 3903-4017 Sentence denotes We next examined whether bFGF contributes to zVAD.fmk-induced necroptosis under normal serum conditions (10% FBS).
T2987 3783-3902 Sentence denotes This confirms that RIP1 kinase is responsible for necroptosis in L929 cells under both serum and serum free conditions.
T2986 3611-3782 Sentence denotes Nec-1i was unable to protect L929 cell death under serum condtions treated with zVAD.fmk or TNFα (Fig. S1B) or serum free conditions treated with bFGF/zVAD.fmk (Fig. S1C).
T2985 3386-3610 Sentence denotes To further validate the role of RIP1, we used an inactive analog, 7-Cl-O-Nec-1i (Nec-1i) (Fig. S1A), which contains an extra N-methyl group that leads to almost complete loss of RIP1 kinase inhibitory activity in vitro [23].
T2984 3175-3385 Sentence denotes This inhibitor efficiently blocked growth factor/zVAD.fmk-induced necroptosis under serum free conditions in L929 cells and both zVAD.fmk and TNFα-induced necroptosis under full serum conditions (Fig. 1B, S1B).
T2983 3069-3174 Sentence denotes Recently, its selectivity has been further validated against a panel of more than 400 human kinases [15].
T2982 2915-3068 Sentence denotes Previously we described the development of 7-Cl-O-Nec-1 (Nec-1) as a potent and selective inhibitor of RIP1 kinase and necroptosis (Fig. S1A) [23], [24].
T2981 1840-2043 Sentence denotes In contrast, TNFα triggered necroptosis equally efficiently in the absence of serum (Fig. 1A), suggesting that either growth factors and zVAD.fmk or TNFα are required for necroptotic death in L929 cells.
T2980 1695-1839 Sentence denotes Furthermore, growth factor-dependent necroptosis required the inhibition of caspase activity, as bFGF alone did not induce cell death (Fig. 1C).
T2979 1514-1694 Sentence denotes Interestingly, this does not reflect a generic requirement for growth factor signaling, as only some growth factors (bFGF and IGF-1, but not EGF and PDGF) promoted death (Fig. 1B).
T2978 1397-1513 Sentence denotes The addition of growth factors, such as bFGF, restored zVAD.fmk induced death under serum free conditions (Fig. 1B).
T2977 1255-1396 Sentence denotes Consistent with a previous report [16], we found that serum starvation of L929 cells prevented necroptosis in response to zVAD.fmk (Fig. 1A).
T2976 871-1254 Sentence denotes These data are reminiscent of the observations in L929 cells where the loss of caspase activity in healthy cells is sufficient to trigger necroptosis and prompted us to explore the extrinsic or intrinsic cellular factors that promote necroptosis once caspase-8 activity, which cleaves and inactivates RIP1 kinase and the RIP1 deubiquitinase CYLD [21], [22], is removed in L929 cells.
T2975 397-870 Sentence denotes Interestingly, while necroptosis was initially identified as a back-up form of cell death triggered by pro-apoptotic stimuli in the presence of apoptosis inhibitors [17], recent analysis of physiological cell death during mouse development has suggested that the loss of apoptotic regulators, such as caspase-8 and FADD [18], [19], [20], leads to robust induction of necroptosis and death of E10.5 embryos even though apoptosis is not normally induced in wild type embryos.
T2974 200-396 Sentence denotes In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosis in these cells [10], [14].
T2973 66-199 Sentence denotes It has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17].
T2972 0-65 Sentence denotes Basic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells
T37 0-65 Sentence denotes Basic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells
T38 66-199 Sentence denotes It has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17].
T39 200-396 Sentence denotes In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosis in these cells [10], [14].
T40 397-870 Sentence denotes Interestingly, while necroptosis was initially identified as a back-up form of cell death triggered by pro-apoptotic stimuli in the presence of apoptosis inhibitors [17], recent analysis of physiological cell death during mouse development has suggested that the loss of apoptotic regulators, such as caspase-8 and FADD [18], [19], [20], leads to robust induction of necroptosis and death of E10.5 embryos even though apoptosis is not normally induced in wild type embryos.
T41 871-1254 Sentence denotes These data are reminiscent of the observations in L929 cells where the loss of caspase activity in healthy cells is sufficient to trigger necroptosis and prompted us to explore the extrinsic or intrinsic cellular factors that promote necroptosis once caspase-8 activity, which cleaves and inactivates RIP1 kinase and the RIP1 deubiquitinase CYLD [21], [22], is removed in L929 cells.
T42 1255-1396 Sentence denotes Consistent with a previous report [16], we found that serum starvation of L929 cells prevented necroptosis in response to zVAD.fmk (Fig. 1A).
T43 1397-1513 Sentence denotes The addition of growth factors, such as bFGF, restored zVAD.fmk induced death under serum free conditions (Fig. 1B).
T44 1514-1694 Sentence denotes Interestingly, this does not reflect a generic requirement for growth factor signaling, as only some growth factors (bFGF and IGF-1, but not EGF and PDGF) promoted death (Fig. 1B).
T45 1695-1839 Sentence denotes Furthermore, growth factor-dependent necroptosis required the inhibition of caspase activity, as bFGF alone did not induce cell death (Fig. 1C).
T46 1840-2043 Sentence denotes In contrast, TNFα triggered necroptosis equally efficiently in the absence of serum (Fig. 1A), suggesting that either growth factors and zVAD.fmk or TNFα are required for necroptotic death in L929 cells.
T47 2044-2148 Sentence denotes 10.1371/journal.pone.0056576.g001 Figure 1 bFGF and IGF-1 promote necroptosis in concert with zVAD.fmk.
T48 2149-2253 Sentence denotes (A) L929 cells were treated with TNFα or zVAD.fmk under normal serum (10% FBS) or serum free conditions.
T49 2254-2336 Sentence denotes Cell viability was determined after 24 hr using the CellTiter-Glo Viability assay.
T50 2337-2875 Sentence denotes The concentrations of all necroptosis-inducing agents are listed in the Materials and Methods section or indicated in the figures. (B) Cells were treated with zVAD.fmk, the indicated growth factors, and Nec-1 under serum free conditions for 24 hrs followed by measurement of cell viability. (C) Cells under serum free conditions were treated with FGF, zVAD.fmk, or both for 24 hrs followed by viability assay. (D) Cell death was induced by zVAD.fmk or TNFα under full serum condition in the presence of 2 µM PD173074 and 20 µM PD166866.
T51 2876-2914 Sentence denotes In all graphs, average±SD was plotted.
T52 2915-3068 Sentence denotes Previously we described the development of 7-Cl-O-Nec-1 (Nec-1) as a potent and selective inhibitor of RIP1 kinase and necroptosis (Fig. S1A) [23], [24].
T53 3069-3174 Sentence denotes Recently, its selectivity has been further validated against a panel of more than 400 human kinases [15].
T54 3175-3385 Sentence denotes This inhibitor efficiently blocked growth factor/zVAD.fmk-induced necroptosis under serum free conditions in L929 cells and both zVAD.fmk and TNFα-induced necroptosis under full serum conditions (Fig. 1B, S1B).
T55 3386-3610 Sentence denotes To further validate the role of RIP1, we used an inactive analog, 7-Cl-O-Nec-1i (Nec-1i) (Fig. S1A), which contains an extra N-methyl group that leads to almost complete loss of RIP1 kinase inhibitory activity in vitro [23].
T56 3611-3782 Sentence denotes Nec-1i was unable to protect L929 cell death under serum condtions treated with zVAD.fmk or TNFα (Fig. S1B) or serum free conditions treated with bFGF/zVAD.fmk (Fig. S1C).
T57 3783-3902 Sentence denotes This confirms that RIP1 kinase is responsible for necroptosis in L929 cells under both serum and serum free conditions.
T58 3903-4017 Sentence denotes We next examined whether bFGF contributes to zVAD.fmk-induced necroptosis under normal serum conditions (10% FBS).
T59 4018-4233 Sentence denotes We used two bFGF receptor tyrosine kinase inhibitors (PD173074 and PD166866), and determined that inhibition of bFGF signaling strongly inhibited zVAD.fmk-induced necroptosis under normal serum conditions (Fig. 1D).
T60 4234-4413 Sentence denotes In contrast, neither bFGF receptor inhibitor was able to attenuate TNFα-induced necroptosis (Fig. 1D), consistent with growth factors being dispensable for this pathway (Fig. 1A).
T61 4414-4551 Sentence denotes Overall, these data suggest that the induction of necroptosis by zVAD.fmk is promoted by bFGF under both serum and serum free conditions.
T62 4552-4698 Sentence denotes The induction of necroptosis, however, is not a simple consequence of growth factor signaling since not all growth factors allowed death to occur.
T63 4699-4814 Sentence denotes Instead, specific signaling events mediated by particular growth factors appear to contribute to necroptotic death.

simple1

Id Subject Object Predicate Lexical cue
T28536 2791-2795 Protein denotes TNFα
T28535 2182-2186 Protein denotes TNFα
T28534 2097-2102 Protein denotes IGF-1
T28533 2088-2092 Protein denotes bFGF
T3199 4503-4507 Protein denotes bFGF
T3198 4301-4305 Protein denotes TNFα
T3197 4255-4268 Protein denotes bFGF receptor
T3196 4130-4134 Protein denotes bFGF
T3195 4030-4059 Protein denotes bFGF receptor tyrosine kinase
T3194 3928-3932 Protein denotes bFGF
T3193 3802-3806 Protein denotes RIP1
T3192 3757-3761 Protein denotes bFGF
T3191 3703-3707 Protein denotes TNFα
T3190 3564-3568 Protein denotes RIP1
T3189 3418-3422 Protein denotes RIP1
T3188 3317-3321 Protein denotes TNFα
T3187 3018-3022 Protein denotes RIP1
T3186 1989-1993 Protein denotes TNFα
T3185 1853-1857 Protein denotes TNFα
T3184 1792-1796 Protein denotes bFGF
T3183 1655-1658 Protein denotes EGF
T3182 1640-1645 Protein denotes IGF-1
T3181 1631-1635 Protein denotes bFGF
T3180 1437-1441 Protein denotes bFGF
T3179 1212-1216 Protein denotes CYLD
T3178 1192-1211 Protein denotes RIP1 deubiquitinase
T3177 1172-1176 Protein denotes RIP1
T3176 1122-1131 Protein denotes caspase-8
T3175 712-716 Protein denotes FADD
T3174 698-707 Protein denotes caspase-8
T3173 227-236 Protein denotes caspase-8
T3172 183-187 Protein denotes TNFα
T3171 0-30 Protein denotes Basic Fibroblast Growth Factor

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T28689 2791-2795 Protein denotes TNFα
T28688 2182-2186 Protein denotes TNFα
T28687 2097-2102 Protein denotes IGF-1
T28686 2088-2092 Protein denotes bFGF
T3950 3556-3560 Negative_regulation denotes loss
T3949 3005-3014 Negative_regulation denotes inhibitor
T3948 1160-1171 Negative_regulation denotes inactivates
T3947 660-664 Negative_regulation denotes loss
T3946 213-223 Negative_regulation denotes inhibition
T3945 4503-4507 Protein denotes bFGF
T3944 4301-4305 Protein denotes TNFα
T3943 4255-4268 Protein denotes bFGF receptor
T3942 4130-4134 Protein denotes bFGF
T3941 4030-4059 Protein denotes bFGF receptor tyrosine kinase
T3940 3928-3932 Protein denotes bFGF
T3939 3802-3806 Protein denotes RIP1
T3938 3757-3761 Protein denotes bFGF
T3937 3703-3707 Protein denotes TNFα
T3936 3564-3568 Protein denotes RIP1
T3935 3418-3422 Protein denotes RIP1
T3934 3317-3321 Protein denotes TNFα
T3933 3018-3022 Protein denotes RIP1
T3932 1989-1993 Protein denotes TNFα
T3931 1853-1857 Protein denotes TNFα
T3930 1792-1796 Protein denotes bFGF
T3929 1655-1658 Protein denotes EGF
T3928 1640-1645 Protein denotes IGF-1
T3927 1631-1635 Protein denotes bFGF
T3926 1437-1441 Protein denotes bFGF
T3925 1212-1216 Protein denotes CYLD
T3924 1192-1211 Protein denotes RIP1 deubiquitinase
T3923 1172-1176 Protein denotes RIP1
T3922 1122-1131 Protein denotes caspase-8
T3921 712-716 Protein denotes FADD
T3920 698-707 Protein denotes caspase-8
T3919 227-236 Protein denotes caspase-8
T3918 183-187 Protein denotes TNFα
T3917 0-30 Protein denotes Basic Fibroblast Growth Factor
T3952 4269-4278 Negative_regulation denotes inhibitor
T3951 4060-4070 Negative_regulation denotes inhibitors
R2722 T3936 T3950 themeOf RIP1,loss
R2723 T3941 T3951 themeOf bFGF receptor tyrosine kinase,inhibitors
R2724 T3943 T3952 themeOf bFGF receptor,inhibitor
R2718 T3919 T3946 themeOf caspase-8,inhibition
R2719 T3920 T3947 themeOf caspase-8,loss
R2720 T3925 T3948 themeOf CYLD,inactivates
R2721 T3933 T3949 themeOf RIP1,inhibitor

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T4078 660-664 Negative_regulation denotes loss
T4077 213-223 Negative_regulation denotes inhibition
T4076 4503-4507 Protein denotes bFGF
T4075 4301-4305 Protein denotes TNFα
T4074 4255-4268 Protein denotes bFGF receptor
T4073 4130-4134 Protein denotes bFGF
T4072 4030-4059 Protein denotes bFGF receptor tyrosine kinase
T4071 3928-3932 Protein denotes bFGF
T4070 3802-3806 Protein denotes RIP1
T4069 3757-3761 Protein denotes bFGF
T4068 3703-3707 Protein denotes TNFα
T4067 3564-3568 Protein denotes RIP1
T4066 3418-3422 Protein denotes RIP1
T4065 3317-3321 Protein denotes TNFα
T4064 3018-3022 Protein denotes RIP1
T4063 1989-1993 Protein denotes TNFα
T4062 1853-1857 Protein denotes TNFα
T4061 1792-1796 Protein denotes bFGF
T4060 1655-1658 Protein denotes EGF
T4059 1640-1645 Protein denotes IGF-1
T4058 1631-1635 Protein denotes bFGF
T4057 1437-1441 Protein denotes bFGF
T4056 1212-1216 Protein denotes CYLD
T4055 1192-1211 Protein denotes RIP1 deubiquitinase
T4054 1172-1176 Protein denotes RIP1
T4053 1122-1131 Protein denotes caspase-8
T4052 712-716 Protein denotes FADD
T4051 698-707 Protein denotes caspase-8
T4050 227-236 Protein denotes caspase-8
T4049 183-187 Protein denotes TNFα
T4048 0-30 Protein denotes Basic Fibroblast Growth Factor
T4082 4306-4313 Positive_regulation denotes induced
T4081 4269-4278 Negative_regulation denotes inhibitor
T4080 4060-4070 Negative_regulation denotes inhibitors
T4079 3005-3014 Negative_regulation denotes inhibitor
T28705 2791-2795 Protein denotes TNFα
T28704 2182-2186 Protein denotes TNFα
T28703 2097-2102 Protein denotes IGF-1
T28702 2088-2092 Protein denotes bFGF
R2745 T4050 T4077 themeOf caspase-8,inhibition
R2746 T4051 T4078 themeOf caspase-8,loss
R2747 T4064 T4079 themeOf RIP1,inhibitor
R2748 T4072 T4080 themeOf bFGF receptor tyrosine kinase,inhibitors
R2749 T4074 T4081 themeOf bFGF receptor,inhibitor
R2750 T4075 T4082 themeOf TNFα,induced

DLUT931

Id Subject Object Predicate Lexical cue
T28697 2791-2795 Protein denotes TNFα
T28696 2182-2186 Protein denotes TNFα
T28695 2097-2102 Protein denotes IGF-1
T28694 2088-2092 Protein denotes bFGF
T4013 4269-4278 Negative_regulation denotes inhibitor
T4012 4116-4126 Negative_regulation denotes inhibition
T4011 4060-4070 Negative_regulation denotes inhibitors
T4010 3817-3828 Regulation denotes responsible
T4009 3556-3560 Negative_regulation denotes loss
T4008 3005-3014 Negative_regulation denotes inhibitor
T4007 1907-1914 Negative_regulation denotes absence
T4006 1160-1171 Positive_regulation denotes inactivates
T4005 660-664 Negative_regulation denotes loss
T4004 274-283 Negative_regulation denotes knockdown
T4003 213-223 Negative_regulation denotes inhibition
T4002 4503-4507 Protein denotes bFGF
T4001 4301-4305 Protein denotes TNFα
T4000 4255-4268 Protein denotes bFGF receptor
T3999 4130-4134 Protein denotes bFGF
T3998 4030-4059 Protein denotes bFGF receptor tyrosine kinase
T3997 3928-3932 Protein denotes bFGF
T3996 3802-3806 Protein denotes RIP1
T3995 3757-3761 Protein denotes bFGF
T3994 3703-3707 Protein denotes TNFα
T3993 3564-3568 Protein denotes RIP1
T3992 3418-3422 Protein denotes RIP1
T3991 3317-3321 Protein denotes TNFα
T3990 3018-3022 Protein denotes RIP1
T3989 1989-1993 Protein denotes TNFα
T3988 1853-1857 Protein denotes TNFα
T3987 1792-1796 Protein denotes bFGF
T3986 1655-1658 Protein denotes EGF
T3985 1640-1645 Protein denotes IGF-1
T3984 1631-1635 Protein denotes bFGF
T3983 1437-1441 Protein denotes bFGF
T3982 1212-1216 Protein denotes CYLD
T3981 1192-1211 Protein denotes RIP1 deubiquitinase
T3980 1172-1176 Protein denotes RIP1
T3979 1122-1131 Protein denotes caspase-8
T3978 712-716 Protein denotes FADD
T3977 698-707 Protein denotes caspase-8
T3976 227-236 Protein denotes caspase-8
T3975 183-187 Protein denotes TNFα
T3974 0-30 Protein denotes Basic Fibroblast Growth Factor
R2726 T3977 T4005 themeOf caspase-8,loss
R2727 T3978 T4005 themeOf FADD,loss
R2728 T3980 T4006 themeOf RIP1,inactivates
R2729 T3981 T4006 themeOf RIP1 deubiquitinase,inactivates
R2730 T3982 T4006 themeOf CYLD,inactivates
R2731 T3988 T4007 themeOf TNFα,absence
R2732 T3990 T4008 themeOf RIP1,inhibitor
R2733 T3993 T4009 themeOf RIP1,loss
R2734 T3996 T4010 themeOf RIP1,responsible
R2735 T3998 T4011 themeOf bFGF receptor tyrosine kinase,inhibitors
R2736 T3999 T4012 themeOf bFGF,inhibition
R2737 T4000 T4013 themeOf bFGF receptor,inhibitor
R2738 T4003 T4004 themeOf inhibition,knockdown
R2725 T3976 T4003 themeOf caspase-8,inhibition

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T28906 2474-2479 Entity denotes Cells
T28905 2182-2186 Protein denotes TNFα
T28904 2691-2699 Entity denotes zVAD.fmk
T28903 2542-2547 Protein denotes Nec-1
T28902 2302-2335 Protein denotes the CellTiter-Glo Viability assay
T28901 2844-2855 Entity denotes µM PD173074
T28900 2498-2507 Entity denotes zVAD.fmk,
T28899 2713-2719 Protein denotes 24 hrs
T28898 2190-2198 Entity denotes zVAD.fmk
T28897 2779-2787 Entity denotes zVAD.fmk
T28896 2219-2226 Protein denotes 10% FBS
T28895 2791-2795 Protein denotes TNFα
T28894 2611-2628 Entity denotes of cell viability
T28893 2088-2092 Protein denotes bFGF
T28892 2580-2628 Protein denotes 24 hrs followed by measurement of cell viability
T28891 2306-2310 Entity denotes Cell
T28890 2097-2102 Protein denotes IGF-1
T28889 2686-2689 Entity denotes FGF
T28888 2139-2147 Entity denotes zVAD.fmk
T28887 2634-2667 Entity denotes Cells under serum free conditions
T4935 3757-3761 Protein denotes bFGF
T4934 323-332 Entity denotes zVAD.fmk,
T4933 296-322 Protein denotes the pan-caspase inhibitor,
T4932 1377-1385 Entity denotes zVAD.fmk
T4931 1172-1183 Protein denotes RIP1 kinase
T4930 3948-3964 Entity denotes zVAD.fmk-induced
T4929 3640-3644 Entity denotes L929
T4928 1631-1635 Protein denotes bFGF
T4927 4008-4015 Protein denotes 10% FBS
T4926 4622-4635 Protein denotes growth factor
T4925 3564-3586 Protein denotes RIP1 kinase inhibitory
T4924 970-983 Entity denotes healthy cells
T4923 1853-1857 Protein denotes TNFα
T4922 4130-4134 Protein denotes bFGF
T4921 3502-3595 Entity denotes an extra N-methyl group that leads to almost complete loss of RIP1 kinase inhibitory activity
T4920 3371-3374 Protein denotes Fig
T4919 4301-4313 Protein denotes TNFα-induced
T4918 0-30 Protein denotes Basic Fibroblast Growth Factor
T4917 1977-1985 Entity denotes zVAD.fmk
T4916 3691-3699 Entity denotes zVAD.fmk
T4915 950-957 Protein denotes caspase
T4992 1753-1788 Negative_regulation denotes the inhibition of caspase activity,
T4991 1142-1211 Negative_regulation denotes which cleaves and inactivates RIP1 kinase and the RIP1 deubiquitinase
T4990 1142-1211 Negative_regulation denotes which cleaves and inactivates RIP1 kinase and the RIP1 deubiquitinase
T4989 4018-4144 Negative_regulation denotes We used two bFGF receptor tyrosine kinase inhibitors (PD173074 and PD166866), and determined that inhibition of bFGF signaling
T4988 4619-4645 Positive_regulation denotes of growth factor signaling
T4987 4127-4144 Positive_regulation denotes of bFGF signaling
T4986 1212-1253 Negative_regulation denotes CYLD [21], [22], is removed in L929 cells
T4985 203-245 Negative_regulation denotes addition, inhibition of caspase-8 activity
T4984 0-31 Localization denotes Basic Fibroblast Growth Factor
T4983 1577-1600 Positive_regulation denotes growth factor signaling
T4982 3175-3189 Entity denotes This inhibitor
T4981 1410-1460 Entity denotes of growth factors, such as bFGF, restored zVAD.fmk
T4980 3564-3568 Protein denotes RIP1
T4979 4260-4268 Protein denotes receptor
T4978 373-395 Entity denotes these cells [10], [14]
T4977 1771-1778 Protein denotes caspase
T4976 6-16 Entity denotes Fibroblast
T4975 3304-3312 Entity denotes zVAD.fmk
T4974 183-198 Protein denotes TNFα [10], [17]
T4973 1640-1645 Protein denotes IGF-1
T4972 3802-3813 Protein denotes RIP1 kinase
T4971 4327-4330 Protein denotes Fig
T4970 4164-4172 Entity denotes zVAD.fmk
T4969 4476-4487 Entity denotes by zVAD.fmk
T4968 1212-1228 Protein denotes CYLD [21], [22],
T4967 1188-1211 Protein denotes the RIP1 deubiquitinase
T4966 1792-1796 Protein denotes bFGF
T4965 1708-1731 Protein denotes growth factor-dependent
T4964 296-322 Entity denotes the pan-caspase inhibitor,
T4963 1172-1176 Protein denotes RIP1
T4962 3415-3422 Protein denotes of RIP1
T4961 712-727 Protein denotes FADD [18], [19]
T4960 2972-2977 Protein denotes Nec-1
T4959 4255-4259 Protein denotes bFGF
T4958 538-566 Entity denotes of apoptosis inhibitors [17]
T4957 3317-3329 Protein denotes TNFα-induced
T4956 4224-4227 Protein denotes Fig
T4955 3762-3770 Entity denotes zVAD.fmk
T4954 1122-1131 Protein denotes caspase-8
T4953 4026-4095 Protein denotes two bFGF receptor tyrosine kinase inhibitors (PD173074 and PD166866),
T4952 1577-1590 Protein denotes growth factor
T4951 227-236 Protein denotes caspase-8
T4950 698-707 Protein denotes caspase-8
T4949 3703-3707 Protein denotes TNFα
T4948 3928-3932 Protein denotes bFGF
T4947 4026-4095 Entity denotes two bFGF receptor tyrosine kinase inhibitors (PD173074 and PD166866),
T4946 2984-3067 Entity denotes potent and selective inhibitor of RIP1 kinase and necroptosis (Fig. S1A) [23], [24]
T4945 1437-1442 Protein denotes bFGF,
T4944 4260-4278 Entity denotes receptor inhibitor
T4943 3018-3029 Protein denotes RIP1 kinase
T4942 3802-3806 Protein denotes RIP1
T4941 1655-1658 Protein denotes EGF
T4940 4500-4507 Protein denotes by bFGF
T4939 4030-4034 Protein denotes bFGF
T4938 1989-1993 Protein denotes TNFα
T4937 3141-3173 Protein denotes more than 400 human kinases [15]
T4936 3018-3022 Protein denotes RIP1
R3458 T4918 T4984 themeOf Basic Fibroblast Growth Factor,Basic Fibroblast Growth Factor
R3461 T4922 T4987 causeOf bFGF,of bFGF signaling
R3463 T4926 T4988 causeOf growth factor,of growth factor signaling
R3466 T4931 T4991 themeOf RIP1 kinase,which cleaves and inactivates RIP1 kinase and the RIP1 deubiquitinase
R3476 T4952 T4983 causeOf growth factor,growth factor signaling
R3486 T4967 T4990 themeOf the RIP1 deubiquitinase,which cleaves and inactivates RIP1 kinase and the RIP1 deubiquitinase
R3488 T4968 T4986 themeOf "CYLD [21], [22],","CYLD [21], [22], is removed in L929 cells"
R3492 T4976 T4984 locationOf Fibroblast,Basic Fibroblast Growth Factor
R3495 T4987 T4989 themeOf of bFGF signaling,"We used two bFGF receptor tyrosine kinase inhibitors (PD173074 and PD166866), and determined that inhibition of bFGF signaling"

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T28875 2913-2914 . denotes .
T28874 2906-2913 VBN denotes plotted
T28873 2902-2905 VBD denotes was
T28872 2899-2901 NNP denotes SD
T28871 2898-2899 NN denotes ±
T28870 2891-2898 JJ denotes average
T28869 2889-2890 , denotes ,
T28868 2883-2889 NNS denotes graphs
T28867 2879-2882 DT denotes all
T28866 2876-2878 IN denotes In
T28865 2874-2875 . denotes .
T28864 2866-2874 NNP denotes PD166866
T28863 2863-2865 NNP denotes µM
T28862 2860-2862 CD denotes 20
T28861 2856-2859 CC denotes and
T28860 2847-2855 NNP denotes PD173074
T28859 2844-2846 NNP denotes µM
T28858 2842-2843 CD denotes 2
T28857 2839-2841 IN denotes of
T28856 2830-2838 NN denotes presence
T28855 2826-2829 DT denotes the
T28854 2823-2825 IN denotes in
T28853 2813-2822 NN denotes condition
T28852 2807-2812 NN denotes serum
T28851 2802-2806 JJ denotes full
T28850 2796-2801 IN denotes under
T28849 2791-2795 NNP denotes TNFα
T28848 2788-2790 CC denotes or
T28847 2779-2787 NNP denotes zVAD.fmk
T28846 2776-2778 IN denotes by
T28845 2768-2775 VBN denotes induced
T28844 2764-2767 VBD denotes was
T28843 2758-2763 NN denotes death
T28842 2753-2757 NNP denotes Cell
T28841 2751-2752 -RRB- denotes )
T28840 2750-2751 NNP denotes D
T28839 2749-2750 -LRB- denotes (
T28838 2747-2748 . denotes .
T28837 2742-2747 NN denotes assay
T28836 2732-2741 NN denotes viability
T28835 2729-2731 IN denotes by
T28834 2720-2728 VBN denotes followed
T28833 2716-2719 NNS denotes hrs
T28832 2713-2715 CD denotes 24
T28831 2709-2712 IN denotes for
T28830 2704-2708 DT denotes both
T28829 2701-2703 CC denotes or
T28828 2699-2700 , denotes ,
T28827 2691-2699 NNP denotes zVAD.fmk
T28826 2689-2690 , denotes ,
T28825 2686-2689 NNP denotes FGF
T28824 2681-2685 IN denotes with
T28823 2673-2680 VBN denotes treated
T28822 2668-2672 VBD denotes were
T28821 2657-2667 NNS denotes conditions
T28820 2652-2656 JJ denotes free
T28819 2646-2651 NN denotes serum
T28818 2640-2645 IN denotes under
T28817 2634-2639 NNS denotes Cells
T28816 2632-2633 -RRB- denotes )
T28815 2631-2632 $ denotes C
T28814 2630-2631 -LRB- denotes (
T28811 2614-2618 NN denotes cell
T28810 2611-2613 IN denotes of
T28809 2599-2610 NN denotes measurement
T28808 2596-2598 IN denotes by
T28807 2587-2595 VBN denotes followed
T28806 2583-2586 NNS denotes hrs
T28805 2580-2582 CD denotes 24
T28804 2576-2579 IN denotes for
T28803 2565-2575 NNS denotes conditions
T28802 2560-2564 JJ denotes free
T28801 2554-2559 NN denotes serum
T28800 2548-2553 IN denotes under
T28799 2542-2547 NN denotes Nec-1
T28798 2538-2541 CC denotes and
T28797 2536-2537 , denotes ,
T28796 2529-2536 NNS denotes factors
T28795 2522-2528 NN denotes growth
T28794 2512-2521 JJ denotes indicated
T28793 2508-2511 DT denotes the
T28792 2506-2507 , denotes ,
T28791 2498-2506 NNP denotes zVAD.fmk
T28790 2493-2497 IN denotes with
T28789 2485-2492 VBN denotes treated
T28788 2480-2484 VBD denotes were
T28787 2474-2479 NNPS denotes Cells
T28786 2472-2473 -RRB- denotes )
T28785 2471-2472 NNP denotes B
T28784 2470-2471 -LRB- denotes (
T28783 2468-2469 . denotes .
T28782 2461-2468 NNS denotes figures
T28781 2457-2460 DT denotes the
T28780 2454-2456 IN denotes in
T28779 2444-2453 VBN denotes indicated
T28778 2441-2443 CC denotes or
T28777 2433-2440 NN denotes section
T28776 2424-2431 NNPS denotes Methods
T28775 2420-2423 CC denotes and
T28774 2410-2419 NNPS denotes Materials
T28773 2405-2408 DT denotes the
T28772 2402-2404 IN denotes in
T28771 2395-2401 VBN denotes listed
T28770 2391-2394 VBP denotes are
T28769 2384-2390 NNS denotes agents
T28768 2363-2383 JJ denotes necroptosis-inducing
T28767 2359-2362 DT denotes all
T28766 2356-2358 IN denotes of
T28765 2341-2355 NNS denotes concentrations
T28764 2337-2340 DT denotes The
T28763 2335-2336 . denotes .
T28762 2330-2335 NN denotes assay
T28761 2320-2329 NN denotes Viability
T28760 2306-2319 NNP denotes CellTiter-Glo
T28759 2302-2305 DT denotes the
T28758 2296-2301 VBG denotes using
T28757 2293-2295 NN denotes hr
T28756 2290-2292 CD denotes 24
T28755 2284-2289 IN denotes after
T28754 2273-2283 VBN denotes determined
T28753 2269-2272 VBD denotes was
T28752 2259-2268 NN denotes viability
T28751 2254-2258 NNP denotes Cell
T28750 2252-2253 . denotes .
T28749 2242-2252 NNS denotes conditions
T28748 2237-2241 JJ denotes free
T28747 2231-2236 NN denotes serum
T28746 2228-2230 CC denotes or
T28745 2226-2227 -RRB- denotes )
T28744 2223-2226 NNP denotes FBS
T28743 2221-2222 NN denotes %
T28742 2219-2221 CD denotes 10
T28741 2218-2219 -LRB- denotes (
T28740 2212-2217 NN denotes serum
T28739 2205-2211 JJ denotes normal
T28738 2199-2204 IN denotes under
T28737 2190-2198 NNP denotes zVAD.fmk
T28736 2187-2189 CC denotes or
T28735 2182-2186 NNP denotes TNFα
T28734 2177-2181 IN denotes with
T28733 2169-2176 VBN denotes treated
T28732 2164-2168 VBD denotes were
T28731 2158-2163 NNS denotes cells
T28730 2153-2157 NNP denotes L929
T28729 2151-2152 -RRB- denotes )
T28728 2150-2151 NNP denotes A
T28727 2149-2150 -LRB- denotes (
T28726 2147-2148 . denotes .
T28725 2139-2147 NNP denotes zVAD.fmk
T28724 2134-2138 IN denotes with
T28723 2126-2133 NN denotes concert
T28722 2123-2125 IN denotes in
T28721 2111-2122 NN denotes necroptosis
T28720 2103-2110 VB denotes promote
T28719 2097-2102 NNP denotes IGF-1
T28718 2093-2096 CC denotes and
T28717 2088-2092 NNP denotes bFGF
T28813 2628-2629 . denotes .
T28812 2619-2628 NN denotes viability
T4369 1273-1281 JJ denotes previous
T4368 1271-1272 DT denotes a
T4857 4813-4814 . denotes .
T4856 4808-4813 NN denotes death
T4855 4796-4807 JJ denotes necroptotic
T4854 4793-4795 TO denotes to
T4853 4782-4792 VB denotes contribute
T4852 4779-4781 TO denotes to
T4851 4772-4778 VBP denotes appear
T4850 4764-4771 NNS denotes factors
T4849 4757-4763 NN denotes growth
T4848 4746-4756 JJ denotes particular
T4847 4743-4745 IN denotes by
T4846 4734-4742 VBN denotes mediated
T4845 4727-4733 NNS denotes events
T4844 4717-4726 VBG denotes signaling
T4843 4708-4716 JJ denotes specific
T4842 4706-4707 , denotes ,
T4841 4699-4706 RB denotes Instead
T4840 4697-4698 . denotes .
T4839 4692-4697 VB denotes occur
T4838 4689-4691 TO denotes to
T4837 4683-4688 NN denotes death
T4836 4675-4682 VBD denotes allowed
T4835 4667-4674 NNS denotes factors
T4834 4660-4666 NN denotes growth
T4833 4656-4659 DT denotes all
T4832 4652-4655 RB denotes not
T4831 4646-4651 IN denotes since
T4830 4636-4645 VBG denotes signaling
T4829 4629-4635 NN denotes factor
T4828 4622-4628 NN denotes growth
T4827 4619-4621 IN denotes of
T4826 4607-4618 NN denotes consequence
T4825 4600-4606 JJ denotes simple
T4824 4598-4599 DT denotes a
T4823 4594-4597 RB denotes not
T4822 4591-4593 VBZ denotes is
T4821 4589-4590 , denotes ,
T4820 4582-4589 RB denotes however
T4819 4580-4581 , denotes ,
T4818 4569-4580 NN denotes necroptosis
T4817 4566-4568 IN denotes of
T4816 4556-4565 NN denotes induction
T4815 4552-4555 DT denotes The
T4814 4550-4551 . denotes .
T4813 4540-4550 NNS denotes conditions
T4812 4535-4539 JJ denotes free
T4811 4529-4534 NN denotes serum
T4810 4525-4528 CC denotes and
T4809 4519-4524 NN denotes serum
T4808 4514-4518 DT denotes both
T4807 4508-4513 IN denotes under
T4806 4503-4507 NNP denotes bFGF
T4805 4500-4502 IN denotes by
T4804 4491-4499 VBN denotes promoted
T4803 4488-4490 VBZ denotes is
T4802 4479-4487 NNP denotes zVAD.fmk
T4801 4476-4478 IN denotes by
T4800 4464-4475 NN denotes necroptosis
T4799 4461-4463 IN denotes of
T4798 4451-4460 NN denotes induction
T4797 4447-4450 DT denotes the
T4796 4442-4446 IN denotes that
T4795 4434-4441 VBP denotes suggest
T4794 4429-4433 NNS denotes data
T4793 4423-4428 DT denotes these
T4792 4421-4422 , denotes ,
T4791 4414-4421 RB denotes Overall
T4790 4412-4413 . denotes .
T4789 4411-4412 -RRB- denotes )
T4788 4409-4411 NNP denotes 1A
T4787 4404-4408 NNP denotes Fig.
T4786 4403-4404 -LRB- denotes (
T4785 4395-4402 NN denotes pathway
T4784 4390-4394 DT denotes this
T4783 4386-4389 IN denotes for
T4782 4374-4385 JJ denotes dispensable
T4781 4368-4373 VBG denotes being
T4780 4360-4367 NNS denotes factors
T4779 4353-4359 NN denotes growth
T4778 4348-4352 IN denotes with
T4777 4337-4347 JJ denotes consistent
T4776 4335-4336 , denotes ,
T4775 4334-4335 -RRB- denotes )
T4774 4332-4334 NNP denotes 1D
T4773 4327-4331 NNP denotes Fig.
T4772 4326-4327 -LRB- denotes (
T4771 4314-4325 NN denotes necroptosis
T4770 4301-4313 JJ denotes TNFα-induced
T4769 4291-4300 VB denotes attenuate
T4768 4288-4290 TO denotes to
T4767 4283-4287 JJ denotes able
T4766 4279-4282 VBD denotes was
T4765 4269-4278 NN denotes inhibitor
T4764 4260-4268 NN denotes receptor
T4763 4255-4259 NN denotes bFGF
T4762 4247-4254 DT denotes neither
T4761 4245-4246 , denotes ,
T4760 4237-4245 NN denotes contrast
T4759 4234-4236 IN denotes In
T4758 4232-4233 . denotes .
T4757 4231-4232 -RRB- denotes )
T4756 4229-4231 NNP denotes 1D
T4755 4224-4228 NNP denotes Fig.
T4754 4223-4224 -LRB- denotes (
T4753 4212-4222 NNS denotes conditions
T4752 4206-4211 NN denotes serum
T4751 4199-4205 JJ denotes normal
T4750 4193-4198 IN denotes under
T4749 4181-4192 NN denotes necroptosis
T4748 4164-4180 JJ denotes zVAD.fmk-induced
T4747 4154-4163 VBN denotes inhibited
T4746 4145-4153 RB denotes strongly
T4745 4135-4144 VBG denotes signaling
T4744 4130-4134 NNP denotes bFGF
T4743 4127-4129 IN denotes of
T4742 4116-4126 NN denotes inhibition
T4741 4111-4115 IN denotes that
T4740 4100-4110 VBD denotes determined
T4739 4096-4099 CC denotes and
T4738 4094-4095 , denotes ,
T4737 4093-4094 -RRB- denotes )
T4736 4085-4093 NNP denotes PD166866
T4735 4081-4084 CC denotes and
T4734 4072-4080 CD denotes PD173074
T4733 4071-4072 -LRB- denotes (
T4732 4060-4070 NNS denotes inhibitors
T4731 4053-4059 NN denotes kinase
T4730 4044-4052 NN denotes tyrosine
T4729 4035-4043 NN denotes receptor
T4728 4030-4034 NN denotes bFGF
T4727 4026-4029 CD denotes two
T4726 4021-4025 VBD denotes used
T4725 4018-4020 PRP denotes We
T4724 4016-4017 . denotes .
T4723 4015-4016 -RRB- denotes )
T4722 4012-4015 NNP denotes FBS
T4721 4010-4011 NN denotes %
T4720 4008-4010 CD denotes 10
T4677 3757-3766 NNP denotes bFGF/zVAD
T4676 3752-3756 IN denotes with
T4675 3744-3751 VBN denotes treated
T4674 3733-3743 NNS denotes conditions
T4673 3728-3732 JJ denotes free
T4672 3722-3727 NN denotes serum
T4671 3719-3721 CC denotes or
T4670 3717-3718 -RRB- denotes )
T4669 3714-3717 CD denotes S1B
T4668 3712-3713 . denotes .
T4667 3709-3712 NNP denotes Fig
T4666 3708-3709 -LRB- denotes (
T4665 3703-3707 NNP denotes TNFα
T4664 3700-3702 CC denotes or
T4663 3691-3699 NNP denotes zVAD.fmk
T4662 3686-3690 IN denotes with
T4661 3678-3685 VBN denotes treated
T4660 3668-3677 NNS denotes condtions
T4659 3662-3667 NN denotes serum
T4658 3656-3661 IN denotes under
T4657 3650-3655 NN denotes death
T4656 3645-3649 NN denotes cell
T4655 3640-3644 NNP denotes L929
T4654 3632-3639 VB denotes protect
T4653 3629-3631 TO denotes to
T4652 3622-3628 JJ denotes unable
T4651 3618-3621 VBD denotes was
T4650 3611-3617 NN denotes Nec-1i
T4649 3609-3610 . denotes .
T4648 3608-3609 NNP denotes ]
T4647 3606-3608 CD denotes 23
T4646 3605-3606 NNP denotes [
T4645 3599-3604 NN denotes vitro
T4644 3596-3598 IN denotes in
T4643 3587-3595 NN denotes activity
T4642 3576-3586 NN denotes inhibitory
T4641 3569-3575 NN denotes kinase
T4640 3564-3568 CD denotes RIP1
T4639 3561-3563 IN denotes of
T4638 3556-3560 NN denotes loss
T4637 3547-3555 JJ denotes complete
T4636 3540-3546 RB denotes almost
T4635 3537-3539 TO denotes to
T4634 3531-3536 VBZ denotes leads
T4633 3526-3530 WDT denotes that
T4632 3520-3525 NN denotes group
T4631 3511-3519 NN denotes N-methyl
T4630 3505-3510 JJ denotes extra
T4629 3502-3504 DT denotes an
T4628 3493-3501 VBZ denotes contains
T4627 3487-3492 WDT denotes which
T4626 3485-3486 , denotes ,
T4625 3484-3485 -RRB- denotes )
T4624 3481-3484 CD denotes S1A
T4623 3479-3480 . denotes .
T4622 3476-3479 NNP denotes Fig
T4621 3475-3476 -LRB- denotes (
T4620 3473-3474 -RRB- denotes )
T4619 3467-3473 NNP denotes Nec-1i
T4618 3466-3467 -LRB- denotes (
T4617 3452-3465 NNP denotes 7-Cl-O-Nec-1i
T4616 3450-3451 , denotes ,
T4615 3444-3450 NN denotes analog
T4614 3435-3443 JJ denotes inactive
T4613 3432-3434 DT denotes an
T4612 3427-3431 VBD denotes used
T4611 3424-3426 PRP denotes we
T4610 3422-3423 , denotes ,
T4609 3418-3422 NNP denotes RIP1
T4608 3415-3417 IN denotes of
T4607 3410-3414 NN denotes role
T4606 3406-3409 DT denotes the
T4605 3397-3405 VB denotes validate
T4604 3389-3396 RBR denotes further
T4603 3386-3388 TO denotes To
T4602 3384-3385 . denotes .
T4601 3383-3384 -RRB- denotes )
T4600 3380-3383 NNP denotes S1B
T4599 3378-3379 , denotes ,
T4598 3376-3378 NNP denotes 1B
T4597 3371-3375 NNP denotes Fig.
T4596 3370-3371 -LRB- denotes (
T4595 3359-3369 NNS denotes conditions
T4594 3353-3358 NN denotes serum
T4593 3348-3352 JJ denotes full
T4592 3342-3347 IN denotes under
T4591 3330-3341 NN denotes necroptosis
T4590 3317-3329 JJ denotes TNFα-induced
T4589 3313-3316 CC denotes and
T4588 3304-3312 NNP denotes zVAD.fmk
T4587 3299-3303 DT denotes both
T4586 3295-3298 CC denotes and
T4585 3289-3294 NNS denotes cells
T4584 3284-3288 NNP denotes L929
T4583 3281-3283 IN denotes in
T4582 3270-3280 NNS denotes conditions
T4581 3265-3269 JJ denotes free
T4580 3259-3264 NN denotes serum
T4579 3253-3258 IN denotes under
T4578 3241-3252 NN denotes necroptosis
T4577 3229-3240 JJ denotes fmk-induced
T4576 3228-3229 . denotes .
T4575 3217-3228 NNP denotes factor/zVAD
T4574 3210-3216 NN denotes growth
T4573 3202-3209 VBN denotes blocked
T4572 3190-3201 RB denotes efficiently
T4571 3180-3189 NN denotes inhibitor
T4570 3175-3179 DT denotes This
T4569 3173-3174 . denotes .
T4568 3172-3173 NNP denotes ]
T4567 3170-3172 CD denotes 15
T4566 3169-3170 NNP denotes [
T4565 3161-3168 NNS denotes kinases
T4564 3155-3160 JJ denotes human
T4563 3151-3154 CD denotes 400
T4562 3146-3150 IN denotes than
T4561 3141-3145 JJR denotes more
T4560 3138-3140 IN denotes of
T4559 3132-3137 NN denotes panel
T4558 3130-3131 DT denotes a
T4557 3122-3129 IN denotes against
T4556 3112-3121 VBN denotes validated
T4555 3104-3111 JJ denotes further
T4554 3099-3103 VBN denotes been
T4553 3095-3098 VBZ denotes has
T4552 3083-3094 NN denotes selectivity
T4551 3079-3082 PRP$ denotes its
T4550 3077-3078 , denotes ,
T4549 3069-3077 RB denotes Recently
T4548 3067-3068 . denotes .
T4547 3066-3067 NNP denotes ]
T4546 3064-3066 CD denotes 24
T4545 3063-3064 NNP denotes [
T4544 3061-3062 , denotes ,
T4543 3060-3061 NNP denotes ]
T4542 3058-3060 CD denotes 23
T4541 3057-3058 NNP denotes [
T4540 3055-3056 -RRB- denotes )
T4539 3052-3055 CD denotes S1A
T4538 3050-3051 . denotes .
T4537 3047-3050 NNP denotes Fig
T4536 3046-3047 -LRB- denotes (
T4535 3034-3045 NN denotes necroptosis
T4534 3030-3033 CC denotes and
T4533 3023-3029 NN denotes kinase
T4532 3018-3022 CD denotes RIP1
T4531 3015-3017 IN denotes of
T4530 3005-3014 NN denotes inhibitor
T4529 2995-3004 JJ denotes selective
T4528 2991-2994 CC denotes and
T4527 2984-2990 JJ denotes potent
T4526 2982-2983 DT denotes a
T4525 2979-2981 IN denotes as
T4524 2977-2978 -RRB- denotes )
T4523 2972-2977 NNP denotes Nec-1
T4522 2971-2972 -LRB- denotes (
T4521 2958-2970 NNP denotes 7-Cl-O-Nec-1
T4520 2955-2957 IN denotes of
T4519 2943-2954 NN denotes development
T4518 2939-2942 DT denotes the
T4517 2929-2938 VBD denotes described
T4516 2926-2928 PRP denotes we
T4515 2915-2925 RB denotes Previously
T4514 2042-2043 . denotes .
T4513 2037-2042 NNS denotes cells
T4512 2032-2036 CD denotes L929
T4511 2029-2031 IN denotes in
T4510 2023-2028 NN denotes death
T4509 2011-2022 JJ denotes necroptotic
T4508 2007-2010 IN denotes for
T4507 1998-2006 VBN denotes required
T4506 1994-1997 VBP denotes are
T4505 1989-1993 NNP denotes TNFα
T4504 1986-1988 CC denotes or
T4503 1977-1985 NNP denotes zVAD.fmk
T4502 1973-1976 CC denotes and
T4501 1965-1972 NNS denotes factors
T4500 1958-1964 NN denotes growth
T4499 1951-1957 CC denotes either
T4498 1946-1950 IN denotes that
T4497 1935-1945 VBG denotes suggesting
T4496 1933-1934 , denotes ,
T4495 1932-1933 -RRB- denotes )
T4494 1930-1932 NNP denotes 1A
T4493 1925-1929 NNP denotes Fig.
T4492 1924-1925 -LRB- denotes (
T4491 1918-1923 NN denotes serum
T4490 1915-1917 IN denotes of
T4489 1907-1914 NN denotes absence
T4488 1903-1906 DT denotes the
T4487 1900-1902 IN denotes in
T4486 1888-1899 RB denotes efficiently
T4485 1880-1887 RB denotes equally
T4484 1868-1879 NN denotes necroptosis
T4483 1858-1867 VBD denotes triggered
T4482 1853-1857 NNP denotes TNFα
T4481 1851-1852 , denotes ,
T4480 1843-1851 NN denotes contrast
T4479 1840-1842 IN denotes In
T4478 1838-1839 . denotes .
T4477 1837-1838 -RRB- denotes )
T4476 1835-1837 NNP denotes 1C
T4475 1830-1834 NNP denotes Fig.
T4474 1829-1830 -LRB- denotes (
T4473 1823-1828 NN denotes death
T4472 1818-1822 NN denotes cell
T4471 1811-1817 VB denotes induce
T4470 1807-1810 RB denotes not
T4469 1803-1806 VBD denotes did
T4468 1797-1802 RB denotes alone
T4467 1792-1796 NNP denotes bFGF
T4466 1789-1791 IN denotes as
T4465 1787-1788 , denotes ,
T4464 1779-1787 NN denotes activity
T4463 1771-1778 NN denotes caspase
T4462 1768-1770 IN denotes of
T4451 1690-1692 NNP denotes 1B
T4450 1685-1689 NNP denotes Fig.
T4449 1684-1685 -LRB- denotes (
T4448 1678-1683 NN denotes death
T4447 1669-1677 VBN denotes promoted
T4446 1667-1668 -RRB- denotes )
T4445 1663-1667 NNP denotes PDGF
T4444 1659-1662 CC denotes and
T4443 1655-1658 NNP denotes EGF
T4442 1651-1654 RB denotes not
T4441 1647-1650 CC denotes but
T4440 1645-1646 , denotes ,
T4439 1640-1645 NNP denotes IGF-1
T4438 1636-1639 CC denotes and
T4437 1631-1635 NNP denotes bFGF
T4436 1630-1631 -LRB- denotes (
T4435 1622-1629 NNS denotes factors
T4434 1615-1621 NN denotes growth
T4433 1610-1614 DT denotes some
T4432 1605-1609 RB denotes only
T4431 1602-1604 IN denotes as
T4430 1600-1601 , denotes ,
T4429 1591-1600 VBG denotes signaling
T4428 1584-1590 NN denotes factor
T4427 1577-1583 NN denotes growth
T4426 1573-1576 IN denotes for
T4425 1561-1572 NN denotes requirement
T4424 1553-1560 JJ denotes generic
T4423 1551-1552 DT denotes a
T4422 1543-1550 VB denotes reflect
T4421 1539-1542 RB denotes not
T4420 1534-1538 VBZ denotes does
T4419 1529-1533 DT denotes this
T4418 1527-1528 , denotes ,
T4417 1514-1527 RB denotes Interestingly
T4416 1512-1513 . denotes .
T4415 1511-1512 -RRB- denotes )
T4414 1509-1511 NNP denotes 1B
T4413 1504-1508 NNP denotes Fig.
T4412 1503-1504 -LRB- denotes (
T4411 1492-1502 NNS denotes conditions
T4410 1487-1491 JJ denotes free
T4409 1481-1486 NN denotes serum
T4408 1475-1480 IN denotes under
T4407 1469-1474 NN denotes death
T4406 1461-1468 VBD denotes induced
T4405 1452-1460 NNP denotes zVAD.fmk
T4404 1443-1451 VBD denotes restored
T4403 1441-1442 , denotes ,
T4402 1437-1441 NNP denotes bFGF
T4401 1434-1436 IN denotes as
T4400 1429-1433 JJ denotes such
T4399 1427-1428 , denotes ,
T4398 1420-1427 NNS denotes factors
T4397 1413-1419 NN denotes growth
T4396 1410-1412 IN denotes of
T4395 1401-1409 NN denotes addition
T4394 1397-1400 DT denotes The
T4393 1395-1396 . denotes .
T4392 1394-1395 -RRB- denotes )
T4391 1392-1394 NNP denotes 1A
T4390 1387-1391 NNP denotes Fig.
T4389 1386-1387 -LRB- denotes (
T4388 1377-1385 NNP denotes zVAD.fmk
T4387 1374-1376 TO denotes to
T4386 1365-1373 NN denotes response
T4385 1362-1364 IN denotes in
T4384 1350-1361 NN denotes necroptosis
T4383 1340-1349 VBD denotes prevented
T4382 1334-1339 NNS denotes cells
T4381 1329-1333 NNP denotes L929
T4380 1326-1328 IN denotes of
T4379 1315-1325 NN denotes starvation
T4378 1309-1314 NN denotes serum
T4377 1304-1308 IN denotes that
T4376 1298-1303 VBD denotes found
T4375 1295-1297 PRP denotes we
T4374 1293-1294 , denotes ,
T4373 1292-1293 NNP denotes ]
T4372 1290-1292 CD denotes 16
T4371 1289-1290 NNP denotes [
T4370 1282-1288 NN denotes report
T4367 1266-1270 IN denotes with
T4366 1255-1265 JJ denotes Consistent
T4365 1253-1254 . denotes .
T4364 1248-1253 NNS denotes cells
T4363 1243-1247 CD denotes L929
T4362 1240-1242 IN denotes in
T4361 1232-1239 VBN denotes removed
T4360 1229-1231 VBZ denotes is
T4359 1227-1228 , denotes ,
T4358 1226-1227 NNP denotes ]
T4357 1224-1226 CD denotes 22
T4356 1223-1224 NNP denotes [
T4355 1221-1222 , denotes ,
T4354 1220-1221 NNP denotes ]
T4353 1218-1220 CD denotes 21
T4352 1217-1218 NNP denotes [
T4351 1212-1216 NNP denotes CYLD
T4350 1197-1211 NN denotes deubiquitinase
T4349 1192-1196 NNP denotes RIP1
T4348 1188-1191 DT denotes the
T4347 1184-1187 CC denotes and
T4346 1177-1183 NN denotes kinase
T4345 1172-1176 CD denotes RIP1
T4344 1160-1171 VBZ denotes inactivates
T4343 1156-1159 CC denotes and
T4342 1148-1155 VBZ denotes cleaves
T4341 1142-1147 WDT denotes which
T4340 1140-1141 , denotes ,
T4339 1132-1140 NN denotes activity
T4338 1122-1131 JJ denotes caspase-8
T4337 1117-1121 RB denotes once
T4336 1105-1116 NN denotes necroptosis
T4335 1097-1104 VBP denotes promote
T4334 1092-1096 WDT denotes that
T4333 1084-1091 NNS denotes factors
T4332 1075-1083 JJ denotes cellular
T4331 1065-1074 JJ denotes intrinsic
T4330 1062-1064 CC denotes or
T4329 1052-1061 JJ denotes extrinsic
T4328 1048-1051 DT denotes the
T4327 1040-1047 VB denotes explore
T4326 1037-1039 TO denotes to
T4325 1034-1036 PRP denotes us
T4324 1025-1033 VBD denotes prompted
T4323 1021-1024 CC denotes and
T4322 1009-1020 NN denotes necroptosis
T4321 1001-1008 VB denotes trigger
T4320 998-1000 TO denotes to
T4319 987-997 JJ denotes sufficient
T4318 984-986 VBZ denotes is
T4317 978-983 NNS denotes cells
T4316 970-977 JJ denotes healthy
T4315 967-969 IN denotes in
T4314 958-966 NN denotes activity
T4313 950-957 NN denotes caspase
T4312 947-949 IN denotes of
T4311 942-946 NN denotes loss
T4310 938-941 DT denotes the
T4309 932-937 WRB denotes where
T4308 926-931 NNS denotes cells
T4307 921-925 NNP denotes L929
T4306 918-920 IN denotes in
T4305 905-917 NNS denotes observations
T4304 901-904 DT denotes the
T4303 898-900 IN denotes of
T4302 886-897 JJ denotes reminiscent
T4301 882-885 VBP denotes are
T4300 877-881 NNS denotes data
T4299 871-876 DT denotes These
T4298 869-870 . denotes .
T4297 862-869 NNS denotes embryos
T4296 857-861 NN denotes type
T4295 852-856 JJ denotes wild
T4294 849-851 IN denotes in
T4293 841-848 VBN denotes induced
T4292 832-840 RB denotes normally
T4291 828-831 RB denotes not
T4290 825-827 VBZ denotes is
T4289 815-824 NN denotes apoptosis
T4288 808-814 IN denotes though
T4287 803-807 RB denotes even
T4286 795-802 NNS denotes embryos
T4285 792-794 CD denotes .5
T4284 789-792 CD denotes E10
T4283 786-788 IN denotes of
T4282 780-785 NN denotes death
T4281 776-779 CC denotes and
T4280 764-775 NN denotes necroptosis
T4279 761-763 IN denotes of
T4278 751-760 NN denotes induction
T4277 744-750 JJ denotes robust
T4276 741-743 TO denotes to
T4275 735-740 VBZ denotes leads
T4274 733-734 , denotes ,
T4273 732-733 NNP denotes ]
T4272 730-732 CD denotes 20
T4271 729-730 NNP denotes [
T4270 727-728 , denotes ,
T4269 726-727 NNP denotes ]
T4268 724-726 CD denotes 19
T4267 723-724 NNP denotes [
T4266 721-722 , denotes ,
T4265 720-721 NNP denotes ]
T4264 718-720 CD denotes 18
T4263 717-718 NNP denotes [
T4262 712-716 NNP denotes FADD
T4719 4007-4008 -LRB- denotes (
T4718 3996-4006 NNS denotes conditions
T4717 3990-3995 NN denotes serum
T4716 3983-3989 JJ denotes normal
T4715 3977-3982 IN denotes under
T4714 3965-3976 NN denotes necroptosis
T4713 3948-3964 JJ denotes zVAD.fmk-induced
T4712 3945-3947 TO denotes to
T4711 3933-3944 VBZ denotes contributes
T4710 3928-3932 NNP denotes bFGF
T4709 3920-3927 IN denotes whether
T4708 3911-3919 VBD denotes examined
T4707 3906-3910 JJ denotes next
T4706 3903-3905 PRP denotes We
T4705 3901-3902 . denotes .
T4704 3891-3901 NNS denotes conditions
T4703 3886-3890 JJ denotes free
T4702 3880-3885 NN denotes serum
T4701 3876-3879 CC denotes and
T4700 3870-3875 NN denotes serum
T4699 3865-3869 DT denotes both
T4698 3859-3864 IN denotes under
T4697 3853-3858 NNS denotes cells
T4696 3848-3852 CD denotes L929
T4695 3845-3847 IN denotes in
T4694 3833-3844 NN denotes necroptosis
T4693 3829-3832 IN denotes for
T4692 3817-3828 JJ denotes responsible
T4691 3814-3816 VBZ denotes is
T4690 3807-3813 NN denotes kinase
T4689 3802-3806 CD denotes RIP1
T4688 3797-3801 IN denotes that
T4687 3788-3796 VBZ denotes confirms
T4686 3783-3787 DT denotes This
T4685 3781-3782 . denotes .
T4684 3780-3781 -RRB- denotes )
T4683 3777-3780 CD denotes S1C
T4682 3775-3776 . denotes .
T4681 3772-3775 NNP denotes Fig
T4680 3771-3772 -LRB- denotes (
T4679 3767-3770 NN denotes fmk
T4678 3766-3767 . denotes .
T4261 708-711 CC denotes and
T4260 698-707 JJ denotes caspase-8
T4259 695-697 IN denotes as
T4258 690-694 JJ denotes such
T4257 688-689 , denotes ,
T4256 678-688 NNS denotes regulators
T4255 668-677 JJ denotes apoptotic
T4254 665-667 IN denotes of
T4253 660-664 NN denotes loss
T4252 656-659 DT denotes the
T4251 651-655 IN denotes that
T4250 641-650 VBN denotes suggested
T4249 637-640 VBZ denotes has
T4248 625-636 NN denotes development
T4247 619-624 NN denotes mouse
T4246 612-618 IN denotes during
T4245 606-611 NN denotes death
T4244 601-605 NN denotes cell
T4243 587-600 JJ denotes physiological
T4242 584-586 IN denotes of
T4241 575-583 NN denotes analysis
T4240 568-574 JJ denotes recent
T4239 566-567 , denotes ,
T4238 565-566 NNP denotes ]
T4237 563-565 CD denotes 17
T4236 562-563 NNP denotes [
T4224 476-480 NN denotes cell
T4223 473-475 IN denotes of
T4222 468-472 NN denotes form
T4221 460-467 JJ denotes back-up
T4220 458-459 DT denotes a
T4219 455-457 IN denotes as
T4218 444-454 VBN denotes identified
T4217 434-443 RB denotes initially
T4216 430-433 VBD denotes was
T4215 418-429 NN denotes necroptosis
T4214 412-417 IN denotes while
T4213 410-411 , denotes ,
T4212 397-410 RB denotes Interestingly
T4211 395-396 . denotes .
T4210 394-395 NNP denotes ]
T4209 392-394 CD denotes 14
T4208 391-392 NNP denotes [
T4207 389-390 , denotes ,
T4206 388-389 NNP denotes ]
T4205 386-388 CD denotes 10
T4204 385-386 NNP denotes [
T4203 379-384 NNS denotes cells
T4202 373-378 DT denotes these
T4201 370-372 IN denotes in
T4200 358-369 NN denotes necroptosis
T4199 350-357 VB denotes trigger
T4198 347-349 TO denotes to
T4197 336-346 JJ denotes sufficient
T4196 333-335 VBZ denotes is
T4195 331-332 , denotes ,
T4194 323-331 NNP denotes zVAD.fmk
T4193 321-322 , denotes ,
T4192 312-321 NN denotes inhibitor
T4191 300-311 NN denotes pan-caspase
T4190 296-299 DT denotes the
T4189 290-295 VBG denotes using
T4188 287-289 IN denotes by
T4187 284-286 CC denotes or
T4186 274-283 NN denotes knockdown
T4185 268-273 NNP denotes siRNA
T4184 260-267 IN denotes through
T4183 253-259 DT denotes either
T4182 251-252 , denotes ,
T4181 246-251 RB denotes alone
T4180 237-245 NN denotes activity
T4179 227-236 JJ denotes caspase-8
T4178 224-226 IN denotes of
T4177 213-223 NN denotes inhibition
T4176 211-212 , denotes ,
T4175 203-211 NN denotes addition
T4174 200-202 IN denotes In
T4173 198-199 . denotes .
T4172 197-198 NNP denotes ]
T4171 195-197 CD denotes 17
T4170 194-195 NNP denotes [
T4169 192-193 , denotes ,
T4168 191-192 NNP denotes ]
T4167 189-191 CD denotes 10
T4166 188-189 NNP denotes [
T4165 183-187 NNP denotes TNFα
T4164 178-182 IN denotes with
T4163 166-177 NN denotes stimulation
T4162 156-165 VBG denotes following
T4161 150-155 NN denotes death
T4160 145-149 NN denotes cell
T4159 133-144 JJ denotes necroptotic
T4158 125-132 VBP denotes undergo
T4157 119-124 NNS denotes cells
T4156 114-118 NNP denotes L929
T4155 101-113 NN denotes fibrosarcoma
T4154 95-100 NN denotes mouse
T4153 90-94 IN denotes that
T4152 78-89 VBN denotes established
T4151 73-77 VBN denotes been
T4150 69-72 VBZ denotes has
T4149 66-68 PRP denotes It
T4148 60-65 NNP denotes Cells
T4147 55-59 NNP denotes L929
T4146 52-54 IN denotes in
T4145 40-51 NNP denotes Necroptosis
T4144 31-39 NNP denotes Promotes
T4143 24-30 NNP denotes Factor
T4142 17-23 NNP denotes Growth
T4141 6-16 NNP denotes Fibroblast
T4140 0-5 JJ denotes Basic
T4461 1757-1767 NN denotes inhibition
T4460 1753-1756 DT denotes the
T4459 1744-1752 VBD denotes required
T4458 1732-1743 NN denotes necroptosis
T4457 1715-1731 JJ denotes factor-dependent
T4456 1708-1714 NN denotes growth
T4455 1706-1707 , denotes ,
T4454 1695-1706 RB denotes Furthermore
T4453 1693-1694 . denotes .
T4452 1692-1693 -RRB- denotes )
T4235 551-561 NNS denotes inhibitors
T4234 541-550 NN denotes apoptosis
T4233 538-540 IN denotes of
T4232 529-537 NN denotes presence
T4231 525-528 DT denotes the
T4230 522-524 IN denotes in
T4229 514-521 NNS denotes stimuli
T4228 500-513 JJ denotes pro-apoptotic
T4227 497-499 IN denotes by
T4226 487-496 VBN denotes triggered
T4225 481-486 NN denotes death
R2760 T4140 T4143 compound Basic,Factor
R2761 T4141 T4143 compound Fibroblast,Factor
R2762 T4142 T4143 compound Growth,Factor
R2763 T4143 T4145 compound Factor,Necroptosis
R2764 T4144 T4145 compound Promotes,Necroptosis
R2765 T4145 T4145 ROOT Necroptosis,Necroptosis
R2766 T4146 T4145 prep in,Necroptosis
R2767 T4147 T4148 compound L929,Cells
R2768 T4148 T4146 pobj Cells,in
R2769 T4149 T4152 nsubjpass It,established
R2770 T4150 T4152 aux has,established
R2771 T4151 T4152 auxpass been,established
R2772 T4152 T4152 ROOT established,established
R2773 T4153 T4158 mark that,undergo
R2774 T4154 T4157 compound mouse,cells
R2775 T4155 T4156 compound fibrosarcoma,L929
R2776 T4156 T4157 compound L929,cells
R2777 T4157 T4158 nsubj cells,undergo
R2778 T4158 T4152 ccomp undergo,established
R2779 T4159 T4163 amod necroptotic,stimulation
R2780 T4160 T4161 compound cell,death
R2781 T4161 T4162 npadvmod death,following
R2782 T4162 T4163 amod following,stimulation
R2783 T4163 T4158 dobj stimulation,undergo
R2784 T4164 T4158 prep with,undergo
R2785 T4165 T4166 compound TNFα,[
R2786 T4166 T4164 pobj [,with
R2787 T4167 T4168 nummod 10,]
R2788 T4168 T4166 conj ],[
R2789 T4169 T4168 punct ",",]
R2790 T4170 T4172 nmod [,]
R2791 T4171 T4172 nummod 17,]
R2792 T4172 T4168 conj ],]
R2793 T4173 T4152 punct .,established
R2794 T4174 T4196 prep In,is
R2795 T4175 T4174 pobj addition,In
R2796 T4176 T4196 punct ",",is
R2797 T4177 T4196 nsubj inhibition,is
R2798 T4178 T4177 prep of,inhibition
R2799 T4179 T4180 amod caspase-8,activity
R2800 T4180 T4178 pobj activity,of
R2801 T4181 T4180 advmod alone,activity
R2802 T4182 T4196 punct ",",is
R2803 T4183 T4196 advcl either,is
R2804 T4184 T4183 prep through,either
R2805 T4185 T4186 compound siRNA,knockdown
R2806 T4186 T4184 pobj knockdown,through
R2807 T4187 T4184 cc or,through
R2808 T4188 T4184 conj by,through
R2809 T4189 T4188 pcomp using,by
R2810 T4190 T4192 det the,inhibitor
R2811 T4191 T4192 compound pan-caspase,inhibitor
R2812 T4192 T4189 dobj inhibitor,using
R2813 T4193 T4196 punct ",",is
R2814 T4194 T4196 nsubj zVAD.fmk,is
R2815 T4195 T4196 punct ",",is
R2816 T4196 T4196 ROOT is,is
R2817 T4197 T4196 acomp sufficient,is
R2818 T4198 T4199 aux to,trigger
R2819 T4199 T4197 xcomp trigger,sufficient
R2820 T4200 T4199 dobj necroptosis,trigger
R2821 T4201 T4200 prep in,necroptosis
R2822 T4202 T4203 det these,cells
R2823 T4203 T4201 pobj cells,in
R2824 T4204 T4206 nmod [,]
R2825 T4205 T4206 nummod 10,]
R2826 T4206 T4200 conj ],necroptosis
R2827 T4207 T4206 punct ",",]
R2828 T4208 T4206 conj [,]
R2829 T4209 T4210 nummod 14,]
R2830 T4210 T4206 conj ],]
R2831 T4211 T4196 punct .,is
R2832 T4212 T4250 advmod Interestingly,suggested
R2833 T4213 T4250 punct ",",suggested
R2834 T4214 T4218 mark while,identified
R2835 T4215 T4218 nsubjpass necroptosis,identified
R2836 T4216 T4218 auxpass was,identified
R2837 T4217 T4218 advmod initially,identified
R2838 T4218 T4250 advcl identified,suggested
R2839 T4284 T4286 nummod E10,embryos
R2840 T4219 T4218 prep as,identified
R2841 T4285 T4286 nummod .5,embryos
R2842 T4220 T4222 det a,form
R2843 T4286 T4283 pobj embryos,of
R2844 T4287 T4290 advmod even,is
R2845 T4288 T4290 mark though,is
R2846 T4289 T4290 nsubj apoptosis,is
R2847 T4290 T4293 auxpass is,induced
R2848 T4221 T4222 amod back-up,form
R2849 T4291 T4293 neg not,induced
R2850 T4292 T4293 advmod normally,induced
R2851 T4293 T4250 ccomp induced,suggested
R2852 T4222 T4219 pobj form,as
R2853 T4294 T4293 prep in,induced
R2854 T4295 T4297 amod wild,embryos
R2855 T4223 T4222 prep of,form
R2856 T4296 T4297 compound type,embryos
R2857 T4297 T4294 pobj embryos,in
R2858 T4298 T4250 punct .,suggested
R2859 T4299 T4300 det These,data
R2860 T4224 T4225 compound cell,death
R2861 T4300 T4301 nsubj data,are
R2862 T4301 T4301 ROOT are,are
R2863 T4302 T4301 acomp reminiscent,are
R2864 T4225 T4223 pobj death,of
R2865 T4303 T4302 prep of,reminiscent
R2866 T4304 T4305 det the,observations
R2867 T4226 T4225 acl triggered,death
R2868 T4305 T4303 pobj observations,of
R2869 T4227 T4226 agent by,triggered
R2870 T4306 T4305 prep in,observations
R2871 T4307 T4308 compound L929,cells
R2872 T4228 T4229 amod pro-apoptotic,stimuli
R2873 T4308 T4306 pobj cells,in
R2874 T4309 T4318 advmod where,is
R2875 T4229 T4227 pobj stimuli,by
R2876 T4310 T4311 det the,loss
R2877 T4311 T4318 nsubj loss,is
R2878 T4312 T4311 prep of,loss
R2879 T4230 T4229 prep in,stimuli
R2880 T4313 T4314 compound caspase,activity
R2881 T4231 T4232 det the,presence
R2882 T4232 T4230 pobj presence,in
R2883 T4314 T4312 pobj activity,of
R2884 T4233 T4232 prep of,presence
R2885 T4315 T4311 prep in,loss
R2886 T4234 T4235 compound apoptosis,inhibitors
R2887 T4235 T4233 pobj inhibitors,of
R2888 T4316 T4317 amod healthy,cells
R2889 T4236 T4238 nmod [,]
R2890 T4237 T4238 nummod 17,]
R2891 T4317 T4315 pobj cells,in
R2892 T4238 T4250 nsubj ],suggested
R2893 T4239 T4238 punct ",",]
R2894 T4318 T4305 relcl is,observations
R2895 T4319 T4318 acomp sufficient,is
R2896 T4320 T4321 aux to,trigger
R2897 T4321 T4319 xcomp trigger,sufficient
R2898 T4322 T4321 dobj necroptosis,trigger
R2899 T4240 T4241 amod recent,analysis
R2900 T4323 T4301 cc and,are
R2901 T4324 T4301 conj prompted,are
R2902 T4325 T4324 dobj us,prompted
R2903 T4326 T4327 aux to,explore
R2904 T4241 T4238 appos analysis,]
R2905 T4327 T4324 xcomp explore,prompted
R2906 T4328 T4333 det the,factors
R2907 T4242 T4241 prep of,analysis
R2908 T4329 T4333 amod extrinsic,factors
R2909 T4330 T4329 cc or,extrinsic
R2910 T4243 T4245 amod physiological,death
R2911 T4331 T4329 conj intrinsic,extrinsic
R2912 T4332 T4333 amod cellular,factors
R2913 T4333 T4327 dobj factors,explore
R2914 T4244 T4245 compound cell,death
R2915 T4334 T4335 nsubj that,promote
R2916 T4335 T4333 relcl promote,factors
R2917 T4336 T4335 dobj necroptosis,promote
R2918 T4337 T4339 nmod once,activity
R2919 T4245 T4242 pobj death,of
R2920 T4338 T4339 amod caspase-8,activity
R2921 T4339 T4333 appos activity,factors
R2922 T4340 T4339 punct ",",activity
R2923 T4246 T4241 prep during,analysis
R2924 T4341 T4342 nsubj which,cleaves
R2925 T4342 T4339 relcl cleaves,activity
R2926 T4343 T4342 cc and,cleaves
R2927 T4247 T4248 compound mouse,development
R2928 T4344 T4342 conj inactivates,cleaves
R2929 T4345 T4346 nummod RIP1,kinase
R2930 T4248 T4246 pobj development,during
R2931 T4346 T4361 nsubjpass kinase,removed
R2932 T4347 T4346 cc and,kinase
R2933 T4348 T4350 det the,deubiquitinase
R2934 T4349 T4350 compound RIP1,deubiquitinase
R2935 T4249 T4250 aux has,suggested
R2936 T4350 T4361 nsubjpass deubiquitinase,removed
R2937 T4250 T4250 ROOT suggested,suggested
R2938 T4351 T4352 compound CYLD,[
R2939 T4352 T4350 appos [,deubiquitinase
R2940 T4353 T4354 nummod 21,]
R2941 T4251 T4275 mark that,leads
R2942 T4354 T4358 nmod ],]
R2943 T4355 T4354 punct ",",]
R2944 T4252 T4253 det the,loss
R2945 T4356 T4354 conj [,]
R2946 T4357 T4358 nummod 22,]
R2947 T4358 T4350 appos ],deubiquitinase
R2948 T4359 T4361 punct ",",removed
R2949 T4360 T4361 auxpass is,removed
R2950 T4361 T4361 ROOT removed,removed
R2951 T4253 T4275 nsubj loss,leads
R2952 T4362 T4361 prep in,removed
R2953 T4363 T4364 nummod L929,cells
R2954 T4364 T4362 pobj cells,in
R2955 T4254 T4253 prep of,loss
R2956 T4365 T4361 punct .,removed
R2957 T4366 T4376 advmod Consistent,found
R2958 T4367 T4366 prep with,Consistent
R2959 T4255 T4256 amod apoptotic,regulators
R2960 T4368 T4370 det a,report
R2961 T4369 T4370 amod previous,report
R2962 T4370 T4367 pobj report,with
R2963 T4256 T4254 pobj regulators,of
R2964 T4371 T4373 nmod [,]
R2965 T4372 T4373 nummod 16,]
R2966 T4373 T4370 appos ],report
R2967 T4257 T4256 punct ",",regulators
R2968 T4374 T4376 punct ",",found
R2969 T4375 T4376 nsubj we,found
R2970 T4258 T4259 amod such,as
R2971 T4376 T4376 ROOT found,found
R2972 T4377 T4383 mark that,prevented
R2973 T4378 T4379 compound serum,starvation
R2974 T4259 T4253 prep as,loss
R2975 T4379 T4383 nsubj starvation,prevented
R2976 T4380 T4379 prep of,starvation
R2977 T4260 T4259 pobj caspase-8,as
R2978 T4261 T4260 cc and,caspase-8
R2979 T4381 T4382 compound L929,cells
R2980 T4262 T4260 conj FADD,caspase-8
R2981 T4382 T4380 pobj cells,of
R2982 T4383 T4376 ccomp prevented,found
R2983 T4384 T4383 dobj necroptosis,prevented
R2984 T4263 T4265 nmod [,]
R2985 T4385 T4383 prep in,prevented
R2986 T4264 T4265 nummod 18,]
R2987 T4265 T4253 appos ],loss
R2988 T4386 T4385 pobj response,in
R2989 T4266 T4267 punct ",",[
R2990 T4267 T4269 nmod [,]
R2991 T4387 T4386 prep to,response
R2992 T4268 T4269 nummod 19,]
R2993 T4388 T4387 pobj zVAD.fmk,to
R2994 T4269 T4253 conj ],loss
R2995 T4389 T4391 punct (,1A
R2996 T4390 T4391 compound Fig.,1A
R2997 T4391 T4388 appos 1A,zVAD.fmk
R2998 T4270 T4269 punct ",",]
R2999 T4271 T4269 conj [,]
R3000 T4272 T4273 nummod 20,]
R3001 T4392 T4388 punct ),zVAD.fmk
R3002 T4273 T4269 npadvmod ],]
R3003 T4393 T4376 punct .,found
R3004 T4394 T4395 det The,addition
R3005 T4274 T4275 punct ",",leads
R3006 T4275 T4293 nsubjpass leads,induced
R3007 T4395 T4404 nsubj addition,restored
R3008 T4276 T4275 prep to,leads
R3009 T4396 T4395 prep of,addition
R3010 T4397 T4398 compound growth,factors
R3011 T4277 T4278 amod robust,induction
R3012 T4398 T4396 pobj factors,of
R3013 T4399 T4398 punct ",",factors
R3014 T4278 T4276 pobj induction,to
R3015 T4400 T4401 amod such,as
R3016 T4279 T4278 prep of,induction
R3017 T4280 T4279 pobj necroptosis,of
R3018 T4401 T4398 prep as,factors
R3019 T4281 T4280 cc and,necroptosis
R3020 T4282 T4280 conj death,necroptosis
R3021 T4402 T4401 pobj bFGF,as
R3022 T4283 T4280 prep of,necroptosis
R3023 T4489 T4487 pobj absence,in
R3024 T4403 T4404 punct ",",restored
R3025 T4404 T4404 ROOT restored,restored
R3026 T4490 T4489 prep of,absence
R3027 T4405 T4406 nsubj zVAD.fmk,induced
R3028 T4406 T4404 ccomp induced,restored
R3029 T4491 T4490 pobj serum,of
R3030 T4407 T4406 dobj death,induced
R3031 T4408 T4406 prep under,induced
R3032 T4409 T4410 npadvmod serum,free
R3033 T4492 T4491 punct (,serum
R3034 T4410 T4411 amod free,conditions
R3035 T4411 T4408 pobj conditions,under
R3036 T4493 T4494 compound Fig.,1A
R3037 T4412 T4414 punct (,1B
R3038 T4413 T4414 compound Fig.,1B
R3039 T4414 T4406 npadvmod 1B,induced
R3040 T4494 T4491 appos 1A,serum
R3041 T4415 T4414 punct ),1B
R3042 T4416 T4404 punct .,restored
R3043 T4417 T4422 advmod Interestingly,reflect
R3044 T4495 T4491 punct ),serum
R3045 T4418 T4422 punct ",",reflect
R3046 T4419 T4422 nsubj this,reflect
R3047 T4420 T4422 aux does,reflect
R3048 T4421 T4422 neg not,reflect
R3049 T4422 T4422 ROOT reflect,reflect
R3050 T4423 T4425 det a,requirement
R3051 T4496 T4483 punct ",",triggered
R3052 T4424 T4425 amod generic,requirement
R3053 T4425 T4422 dobj requirement,reflect
R3054 T4426 T4425 prep for,requirement
R3055 T4497 T4483 advcl suggesting,triggered
R3056 T4427 T4428 compound growth,factor
R3057 T4428 T4426 pobj factor,for
R3058 T4498 T4507 mark that,required
R3059 T4429 T4428 acl signaling,factor
R3060 T4430 T4429 punct ",",signaling
R3061 T4431 T4447 mark as,promoted
R3062 T4499 T4501 preconj either,factors
R3063 T4432 T4435 advmod only,factors
R3064 T4433 T4435 det some,factors
R3065 T4434 T4435 compound growth,factors
R3066 T4500 T4501 compound growth,factors
R3067 T4435 T4447 nsubj factors,promoted
R3068 T4436 T4435 punct (,factors
R3069 T4437 T4435 appos bFGF,factors
R3070 T4438 T4437 cc and,bFGF
R3071 T4501 T4507 nsubjpass factors,required
R3072 T4439 T4437 conj IGF-1,bFGF
R3073 T4440 T4439 punct ",",IGF-1
R3074 T4441 T4439 cc but,IGF-1
R3075 T4502 T4501 cc and,factors
R3076 T4442 T4441 neg not,but
R3077 T4443 T4447 nsubj EGF,promoted
R3078 T4503 T4501 conj zVAD.fmk,factors
R3079 T4444 T4443 cc and,EGF
R3080 T4445 T4443 conj PDGF,EGF
R3081 T4446 T4443 punct ),EGF
R3082 T4447 T4425 advcl promoted,requirement
R3083 T4504 T4503 cc or,zVAD.fmk
R3084 T4448 T4447 dobj death,promoted
R3085 T4449 T4447 punct (,promoted
R3086 T4450 T4451 compound Fig.,1B
R3087 T4505 T4503 conj TNFα,zVAD.fmk
R3088 T4451 T4447 appos 1B,promoted
R3089 T4452 T4425 punct ),requirement
R3090 T4506 T4507 auxpass are,required
R3091 T4453 T4422 punct .,reflect
R3092 T4454 T4459 advmod Furthermore,required
R3093 T4455 T4459 punct ",",required
R3094 T4507 T4497 ccomp required,suggesting
R3095 T4456 T4458 nmod growth,necroptosis
R3096 T4457 T4458 amod factor-dependent,necroptosis
R3097 T4458 T4459 nsubj necroptosis,required
R3098 T4459 T4459 ROOT required,required
R3099 T4460 T4461 det the,inhibition
R3100 T4461 T4459 dobj inhibition,required
R3101 T4462 T4461 prep of,inhibition
R3102 T4508 T4507 prep for,required
R3103 T4463 T4464 compound caspase,activity
R3104 T4464 T4462 pobj activity,of
R3105 T4509 T4510 amod necroptotic,death
R3106 T4465 T4459 punct ",",required
R3107 T4466 T4471 mark as,induce
R3108 T4467 T4471 nsubj bFGF,induce
R3109 T4510 T4508 pobj death,for
R3110 T4468 T4467 advmod alone,bFGF
R3111 T4469 T4471 aux did,induce
R3112 T4470 T4471 neg not,induce
R3113 T4511 T4510 prep in,death
R3114 T4471 T4459 advcl induce,required
R3115 T4472 T4473 compound cell,death
R3116 T4473 T4471 dobj death,induce
R3117 T4474 T4471 punct (,induce
R3118 T4512 T4513 nummod L929,cells
R3119 T4475 T4476 compound Fig.,1C
R3120 T4476 T4471 dobj 1C,induce
R3121 T4513 T4511 pobj cells,in
R3122 T4477 T4471 punct ),induce
R3123 T4478 T4459 punct .,required
R3124 T4479 T4483 prep In,triggered
R3125 T4514 T4483 punct .,triggered
R3126 T4480 T4479 pobj contrast,In
R3127 T4515 T4517 advmod Previously,described
R3128 T4481 T4483 punct ",",triggered
R3129 T4516 T4517 nsubj we,described
R3130 T4482 T4483 nsubj TNFα,triggered
R3131 T4483 T4483 ROOT triggered,triggered
R3132 T4517 T4517 ROOT described,described
R3133 T4484 T4483 dobj necroptosis,triggered
R3134 T4485 T4486 advmod equally,efficiently
R3135 T4486 T4483 advmod efficiently,triggered
R3136 T4518 T4519 det the,development
R3137 T4487 T4483 prep in,triggered
R3138 T4488 T4489 det the,absence
R3139 T4519 T4517 dobj development,described
R3140 T4520 T4519 prep of,development
R3141 T4521 T4520 pobj 7-Cl-O-Nec-1,of
R3142 T4522 T4521 punct (,7-Cl-O-Nec-1
R3143 T4586 T4582 cc and,conditions
R3144 T4587 T4588 preconj both,zVAD.fmk
R3145 T4523 T4521 appos Nec-1,7-Cl-O-Nec-1
R3146 T4588 T4582 conj zVAD.fmk,conditions
R3147 T4589 T4588 cc and,zVAD.fmk
R3148 T4590 T4591 amod TNFα-induced,necroptosis
R3149 T4591 T4588 conj necroptosis,zVAD.fmk
R3150 T4592 T4582 prep under,conditions
R3151 T4524 T4521 punct ),7-Cl-O-Nec-1
R3152 T4593 T4595 amod full,conditions
R3153 T4594 T4595 compound serum,conditions
R3154 T4595 T4592 pobj conditions,under
R3155 T4596 T4582 punct (,conditions
R3156 T4525 T4517 prep as,described
R3157 T4597 T4598 compound Fig.,1B
R3158 T4598 T4582 appos 1B,conditions
R3159 T4599 T4598 punct ",",1B
R3160 T4526 T4530 det a,inhibitor
R3161 T4600 T4598 appos S1B,1B
R3162 T4601 T4598 punct ),1B
R3163 T4527 T4530 amod potent,inhibitor
R3164 T4602 T4582 punct .,conditions
R3165 T4603 T4605 aux To,validate
R3166 T4604 T4605 advmod further,validate
R3167 T4528 T4527 cc and,potent
R3168 T4605 T4612 advcl validate,used
R3169 T4606 T4607 det the,role
R3170 T4607 T4605 dobj role,validate
R3171 T4529 T4527 conj selective,potent
R3172 T4608 T4607 prep of,role
R3173 T4609 T4608 pobj RIP1,of
R3174 T4530 T4525 pobj inhibitor,as
R3175 T4610 T4612 punct ",",used
R3176 T4611 T4612 nsubj we,used
R3177 T4612 T4612 ROOT used,used
R3178 T4531 T4530 prep of,inhibitor
R3179 T4613 T4615 det an,analog
R3180 T4614 T4615 amod inactive,analog
R3181 T4615 T4612 dobj analog,used
R3182 T4532 T4533 nummod RIP1,kinase
R3183 T4616 T4615 punct ",",analog
R3184 T4617 T4615 appos 7-Cl-O-Nec-1i,analog
R3185 T4618 T4617 punct (,7-Cl-O-Nec-1i
R3186 T4533 T4531 pobj kinase,of
R3187 T4619 T4617 appos Nec-1i,7-Cl-O-Nec-1i
R3188 T4620 T4617 punct ),7-Cl-O-Nec-1i
R3189 T4621 T4622 punct (,Fig
R3190 T4622 T4617 appos Fig,7-Cl-O-Nec-1i
R3191 T4534 T4533 cc and,kinase
R3192 T4623 T4612 punct .,used
R3193 T4535 T4533 conj necroptosis,kinase
R3194 T4624 T4624 ROOT S1A,S1A
R3195 T4536 T4537 punct (,Fig
R3196 T4625 T4624 punct ),S1A
R3197 T4626 T4624 punct ",",S1A
R3198 T4627 T4628 nsubj which,contains
R3199 T4628 T4624 relcl contains,S1A
R3200 T4629 T4632 det an,group
R3201 T4630 T4632 amod extra,group
R3202 T4631 T4632 compound N-methyl,group
R3203 T4537 T4533 appos Fig,kinase
R3204 T4632 T4628 dobj group,contains
R3205 T4633 T4634 nsubj that,leads
R3206 T4634 T4632 relcl leads,group
R3207 T4538 T4517 punct .,described
R3208 T4635 T4634 prep to,leads
R3209 T4636 T4637 advmod almost,complete
R3210 T4539 T4539 ROOT S1A,S1A
R3211 T4637 T4638 amod complete,loss
R3212 T4638 T4635 pobj loss,to
R3213 T4540 T4541 punct ),[
R3214 T4639 T4638 prep of,loss
R3215 T4541 T4543 nmod [,]
R3216 T4640 T4643 nummod RIP1,activity
R3217 T4641 T4643 compound kinase,activity
R3218 T4642 T4643 compound inhibitory,activity
R3219 T4542 T4543 nummod 23,]
R3220 T4643 T4639 pobj activity,of
R3221 T4644 T4638 prep in,loss
R3222 T4645 T4646 amod vitro,[
R3223 T4646 T4644 pobj [,in
R3224 T4543 T4543 ROOT ],]
R3225 T4647 T4648 nummod 23,]
R3226 T4544 T4543 punct ",",]
R3227 T4648 T4646 appos ],[
R3228 T4649 T4624 punct .,S1A
R3229 T4650 T4651 nsubj Nec-1i,was
R3230 T4545 T4547 nmod [,]
R3231 T4651 T4651 ROOT was,was
R3232 T4652 T4651 acomp unable,was
R3233 T4653 T4654 aux to,protect
R3234 T4654 T4652 xcomp protect,unable
R3235 T4546 T4547 nummod 24,]
R3236 T4655 T4657 compound L929,death
R3237 T4656 T4657 compound cell,death
R3238 T4657 T4654 dobj death,protect
R3239 T4547 T4543 conj ],]
R3240 T4658 T4654 prep under,protect
R3241 T4659 T4660 compound serum,condtions
R3242 T4660 T4658 pobj condtions,under
R3243 T4548 T4539 punct .,S1A
R3244 T4661 T4660 acl treated,condtions
R3245 T4662 T4661 prep with,treated
R3246 T4549 T4556 advmod Recently,validated
R3247 T4663 T4662 pobj zVAD.fmk,with
R3248 T4664 T4663 cc or,zVAD.fmk
R3249 T4665 T4663 conj TNFα,zVAD.fmk
R3250 T4666 T4667 punct (,Fig
R3251 T4667 T4665 appos Fig,TNFα
R3252 T4668 T4651 punct .,was
R3253 T4550 T4556 punct ",",validated
R3254 T4669 T4669 ROOT S1B,S1B
R3255 T4670 T4669 punct ),S1B
R3256 T4671 T4669 cc or,S1B
R3257 T4672 T4674 nmod serum,conditions
R3258 T4551 T4552 poss its,selectivity
R3259 T4673 T4674 amod free,conditions
R3260 T4674 T4669 conj conditions,S1B
R3261 T4552 T4556 nsubjpass selectivity,validated
R3262 T4675 T4674 acl treated,conditions
R3263 T4676 T4675 prep with,treated
R3264 T4677 T4676 pobj bFGF/zVAD,with
R3265 T4553 T4556 aux has,validated
R3266 T4678 T4669 punct .,S1B
R3267 T4679 T4679 ROOT fmk,fmk
R3268 T4680 T4681 punct (,Fig
R3269 T4681 T4679 appos Fig,fmk
R3270 T4554 T4556 auxpass been,validated
R3271 T4682 T4683 punct .,S1C
R3272 T4555 T4556 advmod further,validated
R3273 T4556 T4556 ROOT validated,validated
R3274 T4557 T4556 prep against,validated
R3275 T4683 T4683 ROOT S1C,S1C
R3276 T4558 T4559 det a,panel
R3277 T4684 T4683 punct ),S1C
R3278 T4685 T4679 punct .,fmk
R3279 T4559 T4557 pobj panel,against
R3280 T4686 T4687 nsubj This,confirms
R3281 T4687 T4687 ROOT confirms,confirms
R3282 T4688 T4691 mark that,is
R3283 T4689 T4690 nummod RIP1,kinase
R3284 T4560 T4559 prep of,panel
R3285 T4690 T4691 nsubj kinase,is
R3286 T4691 T4687 ccomp is,confirms
R3287 T4692 T4691 acomp responsible,is
R3288 T4561 T4563 amod more,400
R3289 T4693 T4692 prep for,responsible
R3290 T4694 T4693 pobj necroptosis,for
R3291 T4562 T4563 quantmod than,400
R3292 T4695 T4691 prep in,is
R3293 T4696 T4697 nummod L929,cells
R3294 T4697 T4695 pobj cells,in
R3295 T4563 T4567 quantmod 400,15
R3296 T4698 T4697 prep under,cells
R3297 T4699 T4700 det both,serum
R3298 T4700 T4698 pobj serum,under
R3299 T4701 T4700 cc and,serum
R3300 T4702 T4704 nmod serum,conditions
R3301 T4564 T4565 amod human,kinases
R3302 T4565 T4566 compound kinases,[
R3303 T4703 T4704 amod free,conditions
R3304 T4566 T4567 quantmod [,15
R3305 T4567 T4560 pobj 15,of
R3306 T4704 T4700 conj conditions,serum
R3307 T4568 T4559 appos ],panel
R3308 T4705 T4687 punct .,confirms
R3309 T4706 T4708 nsubj We,examined
R3310 T4707 T4708 advmod next,examined
R3311 T4569 T4556 punct .,validated
R3312 T4708 T4708 ROOT examined,examined
R3313 T4709 T4711 mark whether,contributes
R3314 T4570 T4571 det This,inhibitor
R3315 T4710 T4711 nsubj bFGF,contributes
R3316 T4711 T4708 ccomp contributes,examined
R3317 T4571 T4573 nsubj inhibitor,blocked
R3318 T4712 T4711 prep to,contributes
R3319 T4713 T4714 amod zVAD.fmk-induced,necroptosis
R3320 T4572 T4573 advmod efficiently,blocked
R3321 T4714 T4712 pobj necroptosis,to
R3322 T4715 T4711 prep under,contributes
R3323 T4573 T4573 ROOT blocked,blocked
R3324 T4716 T4718 amod normal,conditions
R3325 T4717 T4718 compound serum,conditions
R3326 T4718 T4715 pobj conditions,under
R3327 T4574 T4573 dobj growth,blocked
R3328 T4575 T4574 appos factor/zVAD,growth
R3329 T4576 T4573 punct .,blocked
R3330 T4719 T4722 punct (,FBS
R3331 T4720 T4721 nummod 10,%
R3332 T4577 T4578 amod fmk-induced,necroptosis
R3333 T4721 T4722 compound %,FBS
R3334 T4722 T4718 appos FBS,conditions
R3335 T4723 T4711 punct ),contributes
R3336 T4578 T4578 ROOT necroptosis,necroptosis
R3337 T4724 T4708 punct .,examined
R3338 T4725 T4726 nsubj We,used
R3339 T4726 T4726 ROOT used,used
R3340 T4579 T4578 prep under,necroptosis
R3341 T4727 T4732 nummod two,inhibitors
R3342 T4728 T4732 nmod bFGF,inhibitors
R3343 T4580 T4579 pobj serum,under
R3344 T4729 T4732 nmod receptor,inhibitors
R3345 T4730 T4732 nmod tyrosine,inhibitors
R3346 T4731 T4732 compound kinase,inhibitors
R3347 T4581 T4582 amod free,conditions
R3348 T4732 T4726 dobj inhibitors,used
R3349 T4733 T4732 punct (,inhibitors
R3350 T4734 T4732 appos PD173074,inhibitors
R3351 T4735 T4734 cc and,PD173074
R3352 T4736 T4734 conj PD166866,PD173074
R3353 T4737 T4736 punct ),PD166866
R3354 T4582 T4578 appos conditions,necroptosis
R3355 T4738 T4732 punct ",",inhibitors
R3356 T4739 T4726 cc and,used
R3357 T4740 T4726 conj determined,used
R3358 T4583 T4582 prep in,conditions
R3359 T4741 T4747 mark that,inhibited
R3360 T4742 T4747 nsubj inhibition,inhibited
R3361 T4743 T4742 prep of,inhibition
R3362 T4584 T4585 compound L929,cells
R3363 T4744 T4743 pobj bFGF,of
R3364 T4745 T4742 acl signaling,inhibition
R3365 T4746 T4747 advmod strongly,inhibited
R3366 T4747 T4740 ccomp inhibited,determined
R3367 T4585 T4583 pobj cells,in
R3368 T4748 T4749 amod zVAD.fmk-induced,necroptosis
R3369 T4749 T4747 dobj necroptosis,inhibited
R3370 T4750 T4747 prep under,inhibited
R3371 T4780 T4781 nsubj factors,being
R3372 T4751 T4753 amod normal,conditions
R3373 T4781 T4778 pcomp being,with
R3374 T4752 T4753 compound serum,conditions
R3375 T4753 T4750 pobj conditions,under
R3376 T4754 T4756 punct (,1D
R3377 T4782 T4781 acomp dispensable,being
R3378 T4755 T4756 compound Fig.,1D
R3379 T4756 T4753 appos 1D,conditions
R3380 T4757 T4747 punct ),inhibited
R3381 T4783 T4782 prep for,dispensable
R3382 T4758 T4726 punct .,used
R3383 T4759 T4766 prep In,was
R3384 T4760 T4759 pobj contrast,In
R3385 T4784 T4785 det this,pathway
R3386 T4785 T4783 pobj pathway,for
R3387 T4761 T4766 punct ",",was
R3388 T4786 T4785 punct (,pathway
R3389 T4762 T4765 det neither,inhibitor
R3390 T4763 T4765 compound bFGF,inhibitor
R3391 T4787 T4788 compound Fig.,1A
R3392 T4764 T4765 compound receptor,inhibitor
R3393 T4765 T4766 nsubj inhibitor,was
R3394 T4766 T4766 ROOT was,was
R3395 T4788 T4785 appos 1A,pathway
R3396 T4767 T4766 acomp able,was
R3397 T4768 T4769 aux to,attenuate
R3398 T4789 T4785 punct ),pathway
R3399 T4769 T4767 xcomp attenuate,able
R3400 T4770 T4771 amod TNFα-induced,necroptosis
R3401 T4771 T4769 dobj necroptosis,attenuate
R3402 T4772 T4771 punct (,necroptosis
R3403 T4773 T4774 compound Fig.,1D
R3404 T4774 T4771 appos 1D,necroptosis
R3405 T4775 T4771 punct ),necroptosis
R3406 T4790 T4766 punct .,was
R3407 T4776 T4771 punct ",",necroptosis
R3408 T4777 T4769 prep consistent,attenuate
R3409 T4778 T4777 prep with,consistent
R3410 T4791 T4795 advmod Overall,suggest
R3411 T4779 T4780 compound growth,factors
R3412 T4792 T4795 punct ",",suggest
R3413 T4793 T4794 det these,data
R3414 T4794 T4795 nsubj data,suggest
R3415 T4795 T4795 ROOT suggest,suggest
R3416 T4796 T4804 mark that,promoted
R3417 T4797 T4798 det the,induction
R3418 T4798 T4804 nsubjpass induction,promoted
R3419 T4799 T4798 prep of,induction
R3421 T4800 T4799 pobj necroptosis,of
R3422 T4801 T4798 prep by,induction
R3425 T4802 T4801 pobj zVAD.fmk,by
R3427 T4803 T4804 auxpass is,promoted
R3428 T4804 T4795 ccomp promoted,suggest
R3429 T4805 T4804 agent by,promoted
R3430 T4806 T4805 pobj bFGF,by
R3432 T4807 T4804 prep under,promoted
R3433 T4808 T4809 det both,serum
R3435 T4809 T4807 pobj serum,under
R3436 T4810 T4809 cc and,serum
R3438 T4811 T4813 nmod serum,conditions
R3439 T4812 T4813 amod free,conditions
R3441 T4813 T4809 conj conditions,serum
R3442 T4814 T4795 punct .,suggest
R3443 T4815 T4816 det The,induction
R3444 T4816 T4822 nsubj induction,is
R3445 T4817 T4816 prep of,induction
R3446 T4818 T4817 pobj necroptosis,of
R3448 T4819 T4822 punct ",",is
R3449 T4820 T4822 advmod however,is
R3450 T4821 T4822 punct ",",is
R3451 T4822 T4822 ROOT is,is
R3452 T4823 T4822 neg not,is
R3453 T4824 T4826 det a,consequence
R3454 T4825 T4826 amod simple,consequence
R3455 T4826 T4822 attr consequence,is
R3456 T4827 T4826 prep of,consequence
R3457 T4828 T4829 compound growth,factor
R3459 T4829 T4827 pobj factor,of
R3460 T4830 T4829 acl signaling,factor
R3462 T4831 T4836 mark since,allowed
R3464 T4832 T4835 neg not,factors
R3465 T4833 T4835 det all,factors
R3467 T4834 T4835 compound growth,factors
R3468 T4835 T4836 nsubj factors,allowed
R3469 T4836 T4826 advcl allowed,consequence
R3470 T4837 T4839 nsubj death,occur
R3471 T4838 T4839 aux to,occur
R3472 T4839 T4836 ccomp occur,allowed
R3473 T4840 T4822 punct .,is
R3474 T4841 T4851 advmod Instead,appear
R3475 T4842 T4851 punct ",",appear
R3477 T4843 T4845 amod specific,events
R3478 T4844 T4845 amod signaling,events
R3479 T4845 T4851 nsubj events,appear
R3480 T4846 T4845 acl mediated,events
R3481 T4847 T4846 agent by,mediated
R3482 T4848 T4850 amod particular,factors
R3483 T4849 T4850 compound growth,factors
R3484 T4850 T4847 pobj factors,by
R3485 T4851 T4851 ROOT appear,appear
R3487 T4852 T4853 aux to,contribute
R3489 T4853 T4851 xcomp contribute,appear
R3490 T4854 T4853 prep to,contribute
R3491 T4855 T4856 amod necroptotic,death
R3493 T4856 T4854 pobj death,to
R3494 T4857 T4851 punct .,appear
R19906 T28717 T28720 nsubj bFGF,promote
R19907 T28718 T28717 cc and,bFGF
R19908 T28719 T28717 conj IGF-1,bFGF
R19909 T28720 T28720 ROOT promote,promote
R19910 T28721 T28720 dobj necroptosis,promote
R19911 T28722 T28720 prep in,promote
R19912 T28723 T28722 pobj concert,in
R19913 T28724 T28723 prep with,concert
R19914 T28725 T28724 pobj zVAD.fmk,with
R19915 T28726 T28720 punct .,promote
R19916 T28727 T28733 punct (,treated
R19917 T28728 T28731 nmod A,cells
R19918 T28729 T28728 punct ),A
R19919 T28730 T28731 compound L929,cells
R19920 T28731 T28733 nsubjpass cells,treated
R19921 T28732 T28733 auxpass were,treated
R19922 T28733 T28733 ROOT treated,treated
R19923 T28734 T28733 prep with,treated
R19924 T28735 T28734 pobj TNFα,with
R19925 T28736 T28735 cc or,TNFα
R19926 T28737 T28735 conj zVAD.fmk,TNFα
R19927 T28738 T28733 prep under,treated
R19928 T28739 T28740 amod normal,serum
R19929 T28740 T28738 pobj serum,under
R19930 T28741 T28744 punct (,FBS
R19931 T28742 T28743 nummod 10,%
R19932 T28743 T28744 compound %,FBS
R19933 T28744 T28733 npadvmod FBS,treated
R19934 T28745 T28744 punct ),FBS
R19935 T28746 T28733 cc or,treated
R19936 T28747 T28749 nmod serum,conditions
R19937 T28748 T28749 amod free,conditions
R19938 T28749 T28733 conj conditions,treated
R19939 T28750 T28733 punct .,treated
R19940 T28751 T28752 compound Cell,viability
R19941 T28752 T28754 nsubjpass viability,determined
R19942 T28753 T28754 auxpass was,determined
R19943 T28754 T28754 ROOT determined,determined
R19944 T28755 T28754 prep after,determined
R19945 T28756 T28757 nummod 24,hr
R19946 T28757 T28755 pobj hr,after
R19947 T28758 T28754 advcl using,determined
R19948 T28759 T28762 det the,assay
R19949 T28760 T28762 compound CellTiter-Glo,assay
R19950 T28761 T28762 compound Viability,assay
R19951 T28762 T28758 dobj assay,using
R19952 T28763 T28754 punct .,determined
R19953 T28764 T28765 det The,concentrations
R19954 T28765 T28771 nsubjpass concentrations,listed
R19955 T28766 T28765 prep of,concentrations
R19956 T28767 T28769 det all,agents
R19957 T28768 T28769 amod necroptosis-inducing,agents
R19958 T28769 T28766 pobj agents,of
R19959 T28770 T28771 auxpass are,listed
R19960 T28771 T28771 ROOT listed,listed
R19961 T28772 T28771 prep in,listed
R19962 T28773 T28774 det the,Materials
R19963 T28774 T28772 pobj Materials,in
R19964 T28775 T28774 cc and,Materials
R19965 T28776 T28777 compound Methods,section
R19966 T28777 T28779 nsubj section,indicated
R19967 T28778 T28777 cc or,section
R19968 T28779 T28771 conj indicated,listed
R19969 T28780 T28779 prep in,indicated
R19970 T28781 T28782 det the,figures
R19971 T28782 T28780 pobj figures,in
R19972 T28783 T28779 punct .,indicated
R19973 T28784 T28785 punct (,B
R19974 T28785 T28785 ROOT B,B
R19975 T28786 T28785 punct ),B
R19976 T28787 T28789 nsubjpass Cells,treated
R19977 T28788 T28789 auxpass were,treated
R19978 T28789 T28789 ROOT treated,treated
R19979 T28790 T28789 prep with,treated
R19980 T28791 T28790 pobj zVAD.fmk,with
R19981 T28792 T28791 punct ",",zVAD.fmk
R19982 T28793 T28796 det the,factors
R19983 T28794 T28796 amod indicated,factors
R19984 T28795 T28796 compound growth,factors
R19985 T28796 T28790 pobj factors,with
R19986 T28797 T28789 punct ",",treated
R19987 T28798 T28789 cc and,treated
R19988 T28799 T28789 conj Nec-1,treated
R19989 T28800 T28799 prep under,Nec-1
R19990 T28801 T28802 npadvmod serum,free
R19991 T28802 T28803 amod free,conditions
R19992 T28803 T28800 pobj conditions,under
R19993 T28804 T28799 prep for,Nec-1
R19994 T28805 T28806 nummod 24,hrs
R19995 T28806 T28804 pobj hrs,for
R19996 T28807 T28806 acl followed,hrs
R19997 T28808 T28807 agent by,followed
R19998 T28809 T28808 pobj measurement,by
R19999 T28810 T28809 prep of,measurement
R20000 T28811 T28812 compound cell,viability
R20001 T28812 T28810 pobj viability,of
R20002 T28813 T28789 punct .,treated
R20003 T28814 T28815 punct (,C
R20004 T28815 T28815 ROOT C,C
R20005 T28816 T28815 punct ),C
R20006 T28817 T28823 nsubjpass Cells,treated
R20007 T28818 T28817 prep under,Cells
R20008 T28819 T28818 pobj serum,under
R20009 T28820 T28821 amod free,conditions
R20010 T28821 T28823 nsubjpass conditions,treated
R20011 T28822 T28823 auxpass were,treated
R20012 T28823 T28823 ROOT treated,treated
R20013 T28824 T28823 prep with,treated
R20014 T28825 T28824 pobj FGF,with
R20015 T28826 T28825 punct ",",FGF
R20016 T28827 T28825 conj zVAD.fmk,FGF
R20017 T28828 T28827 punct ",",zVAD.fmk
R20018 T28829 T28823 cc or,treated
R20019 T28830 T28831 advmod both,for
R20020 T28831 T28823 prep for,treated
R20021 T28832 T28833 nummod 24,hrs
R20022 T28833 T28831 pobj hrs,for
R20023 T28834 T28833 acl followed,hrs
R20024 T28835 T28834 agent by,followed
R20025 T28836 T28837 compound viability,assay
R20026 T28837 T28835 pobj assay,by
R20027 T28838 T28823 punct .,treated
R20028 T28839 T28845 punct (,induced
R20029 T28840 T28843 nmod D,death
R20030 T28841 T28840 punct ),D
R20031 T28842 T28843 compound Cell,death
R20032 T28843 T28845 nsubjpass death,induced
R20033 T28844 T28845 auxpass was,induced
R20034 T28845 T28845 ROOT induced,induced
R20035 T28846 T28845 agent by,induced
R20036 T28847 T28846 pobj zVAD.fmk,by
R20037 T28848 T28847 cc or,zVAD.fmk
R20038 T28849 T28847 conj TNFα,zVAD.fmk
R20039 T28850 T28845 prep under,induced
R20040 T28851 T28853 amod full,condition
R20041 T28852 T28853 compound serum,condition
R20042 T28853 T28850 pobj condition,under
R20043 T28854 T28845 prep in,induced
R20044 T28855 T28856 det the,presence
R20045 T28856 T28854 pobj presence,in
R20046 T28857 T28856 prep of,presence
R20047 T28858 T28860 nummod 2,PD173074
R20048 T28859 T28860 compound µM,PD173074
R20049 T28860 T28857 pobj PD173074,of
R20050 T28861 T28860 cc and,PD173074
R20051 T28862 T28864 nummod 20,PD166866
R20052 T28863 T28864 compound µM,PD166866
R20053 T28864 T28860 conj PD166866,PD173074
R20054 T28865 T28845 punct .,induced
R20055 T28866 T28874 prep In,plotted
R20056 T28867 T28868 det all,graphs
R20057 T28868 T28866 pobj graphs,In
R20058 T28869 T28874 punct ",",plotted
R20059 T28870 T28871 amod average,±
R20060 T28871 T28872 compound ±,SD
R20061 T28872 T28874 nsubjpass SD,plotted
R20062 T28873 T28874 auxpass was,plotted
R20063 T28874 T28874 ROOT plotted,plotted
R20064 T28875 T28874 punct .,plotted

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T28716 2863-2874 Protein denotes µM PD166866
T28715 2844-2855 Protein denotes µM PD173074
T28714 2779-2795 Protein denotes zVAD.fmk or TNFα
T28713 2691-2699 Protein denotes zVAD.fmk
T28712 2686-2689 Protein denotes FGF
T28711 2542-2547 Protein denotes Nec-1
T28710 2190-2198 Protein denotes zVAD.fmk
T28709 2182-2186 Protein denotes TNFα
T28708 2139-2147 Protein denotes zVAD.fmk
T28707 2097-2102 Protein denotes IGF-1
T28706 2088-2092 Protein denotes bFGF
T4139 4503-4507 Protein denotes bFGF
T4138 4479-4487 Protein denotes zVAD.fmk
T4137 4269-4278 Negative_regulation denotes inhibitor
T4136 4301-4305 Protein denotes TNFα
T4135 4255-4268 Protein denotes bFGF receptor
T4134 4169-4172 Protein denotes fmk
T4133 4164-4168 Protein denotes zVAD
T4132 4130-4134 Protein denotes bFGF
T4131 4030-4059 Protein denotes bFGF receptor tyrosine kinase
T4130 3928-3932 Protein denotes bFGF
T4129 3802-3813 Protein denotes RIP1 kinase
T4128 3777-3780 Protein denotes S1C
T4127 3772-3775 Protein denotes Fig
T4126 3757-3770 Protein denotes bFGF/zVAD.fmk
T4125 3709-3717 Protein denotes Fig. S1B
T4124 3703-3707 Protein denotes TNFα
T4123 3691-3699 Protein denotes zVAD.fmk
T4122 3611-3617 Protein denotes Nec-1i
T4121 3556-3560 Negative_regulation denotes loss
T4120 3564-3575 Protein denotes RIP1 kinase
T4119 3481-3484 Protein denotes S1A
T4118 3476-3479 Protein denotes Fig
T4117 3418-3422 Protein denotes RIP1
T4116 3202-3209 Negative_regulation denotes blocked
T4115 3317-3321 Protein denotes TNFα
T4114 3304-3312 Protein denotes zVAD.fmk
T4113 3005-3014 Negative_regulation denotes inhibitor
T4112 3052-3055 Protein denotes S1A
T4111 3047-3050 Protein denotes Fig
T4110 3018-3029 Protein denotes RIP1 kinase
T4109 1989-1993 Protein denotes TNFα
T4108 1977-1985 Protein denotes zVAD.fmk
T4107 1853-1857 Protein denotes TNFα
T4106 1757-1767 Negative_regulation denotes inhibition
T4105 1792-1796 Protein denotes bFGF
T4104 1771-1778 Protein denotes caspase
T4103 1663-1667 Protein denotes PDGF
T4102 1655-1658 Protein denotes EGF
T4101 1640-1645 Protein denotes IGF-1
T4100 1631-1635 Protein denotes bFGF
T4099 1443-1460 Protein denotes restored zVAD.fmk
T4098 1437-1441 Protein denotes bFGF
T4097 1340-1349 Negative_regulation denotes prevented
T4096 1387-1394 Protein denotes Fig. 1A
T4095 1377-1385 Protein denotes zVAD.fmk
T4094 1160-1171 Positive_regulation denotes inactivates
T4093 1160-1171 Positive_regulation denotes inactivates
T4092 942-946 Negative_regulation denotes loss
T4091 1192-1211 Protein denotes RIP1 deubiquitinase
T4090 1172-1183 Protein denotes RIP1 kinase
T4089 1122-1129 Protein denotes caspase
T4088 950-957 Protein denotes caspase
T4087 698-705 Protein denotes caspase
T4086 323-331 Protein denotes zVAD.fmk
T4085 304-311 Protein denotes caspase
T4084 227-234 Protein denotes caspase
T4083 183-192 Protein denotes TNFα [10]
R2751 T4088 T4092 themeOf caspase,loss
R2752 T4090 T4093 themeOf RIP1 kinase,inactivates
R2753 T4091 T4094 themeOf RIP1 deubiquitinase,inactivates
R2754 T4095 T4097 themeOf zVAD.fmk,prevented
R2755 T4104 T4106 themeOf caspase,inhibition
R2756 T4110 T4113 themeOf RIP1 kinase,inhibitor
R2757 T4114 T4116 themeOf zVAD.fmk,blocked
R2758 T4120 T4121 themeOf RIP1 kinase,loss
R2759 T4135 T4137 themeOf bFGF receptor,inhibitor

test3

Id Subject Object Predicate Lexical cue
T28498 2791-2795 Protein denotes TNFα
T28497 2768-2775 Positive_regulation denotes induced
T28496 2182-2186 Protein denotes TNFα
T28495 2097-2102 Protein denotes IGF-1
T28494 2088-2092 Protein denotes bFGF
T28493 2791-2795 Protein denotes TNFα
T28492 2182-2186 Protein denotes TNFα
T28491 2097-2102 Protein denotes IGF-1
T28490 2088-2092 Protein denotes bFGF
T2913 3564-3568 Protein denotes RIP1
T2912 3418-3422 Protein denotes RIP1
T2911 3317-3321 Protein denotes TNFα
T2910 3018-3022 Protein denotes RIP1
T2909 1989-1993 Protein denotes TNFα
T2908 1853-1857 Protein denotes TNFα
T2907 1792-1796 Protein denotes bFGF
T2906 1655-1658 Protein denotes EGF
T2905 1640-1645 Protein denotes IGF-1
T2904 1631-1635 Protein denotes bFGF
T2903 1437-1441 Protein denotes bFGF
T2902 1212-1216 Protein denotes CYLD
T2901 1192-1211 Protein denotes RIP1 deubiquitinase
T2900 1172-1176 Protein denotes RIP1
T2899 1122-1131 Protein denotes caspase-8
T2898 712-716 Protein denotes FADD
T2897 698-707 Protein denotes caspase-8
T2896 227-236 Protein denotes caspase-8
T2895 183-187 Protein denotes TNFα
T2894 0-30 Protein denotes Basic Fibroblast Growth Factor
T2956 4503-4507 Protein denotes bFGF
T2955 4491-4499 Positive_regulation denotes promoted
T2954 4451-4460 Positive_regulation denotes induction
T2953 4306-4313 Positive_regulation denotes induced
T2952 4301-4305 Protein denotes TNFα
T2951 4255-4268 Protein denotes bFGF receptor
T2950 4130-4134 Protein denotes bFGF
T2949 4030-4059 Protein denotes bFGF receptor tyrosine kinase
T2948 3928-3932 Protein denotes bFGF
T2947 3802-3806 Protein denotes RIP1
T2946 3757-3761 Protein denotes bFGF
T2945 3703-3707 Protein denotes TNFα
T2944 3564-3568 Protein denotes RIP1
T2943 3418-3422 Protein denotes RIP1
T2942 3322-3329 Positive_regulation denotes induced
T2941 3317-3321 Protein denotes TNFα
T2940 3018-3022 Protein denotes RIP1
T2939 1989-1993 Protein denotes TNFα
T2938 1853-1857 Protein denotes TNFα
T2937 1792-1796 Protein denotes bFGF
T2936 1655-1658 Protein denotes EGF
T2935 1640-1645 Protein denotes IGF-1
T2934 1631-1635 Protein denotes bFGF
T2933 1437-1441 Protein denotes bFGF
T2932 1212-1216 Protein denotes CYLD
T2931 1192-1211 Protein denotes RIP1 deubiquitinase
T2930 1172-1176 Protein denotes RIP1
T2929 1122-1131 Protein denotes caspase-8
T2928 712-716 Protein denotes FADD
T2927 698-707 Protein denotes caspase-8
T2926 227-236 Protein denotes caspase-8
T2925 183-187 Protein denotes TNFα
T2924 156-165 Positive_regulation denotes following
T2923 0-30 Protein denotes Basic Fibroblast Growth Factor
T2922 4503-4507 Protein denotes bFGF
T2921 4301-4305 Protein denotes TNFα
T2920 4255-4268 Protein denotes bFGF receptor
T2919 4130-4134 Protein denotes bFGF
T2918 4030-4059 Protein denotes bFGF receptor tyrosine kinase
T2917 3928-3932 Protein denotes bFGF
T2916 3802-3806 Protein denotes RIP1
T2915 3757-3761 Protein denotes bFGF
T2914 3703-3707 Protein denotes TNFα
R1991 T2954 T2955 themeOf induction,promoted
R1992 T2956 T2955 causeOf bFGF,promoted