PMC:3585731 / 5019-5657 JSONTXT

{"project":"testone","denotations":[{"id":"T2859","span":{"begin":497,"end":506},"obj":"Protein"},{"id":"T2858","span":{"begin":453,"end":457},"obj":"Protein"},{"id":"T2857","span":{"begin":270,"end":300},"obj":"Protein"},{"id":"T825","span":{"begin":62,"end":72},"obj":"Gene_expression"},{"id":"T824","span":{"begin":49,"end":53},"obj":"Regulation"},{"id":"T813","span":{"begin":57,"end":61},"obj":"Protein"}],"relations":[{"id":"R499","pred":"themeOf","subj":"T813","obj":"T825"},{"id":"R504","pred":"themeOf","subj":"T825","obj":"T824"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"2_test","denotations":[{"id":"23469174-19109899-90505413","span":{"begin":459,"end":461},"obj":"19109899"},{"id":"23469174-16408008-90505414","span":{"begin":465,"end":467},"obj":"16408008"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"pmc-enju-pas","denotations":[{"id":"T3277","span":{"begin":620,"end":627},"obj":"VB"},{"id":"T3276","span":{"begin":617,"end":619},"obj":"TO"},{"id":"T3275","span":{"begin":606,"end":616},"obj":"JJ"},{"id":"T3274","span":{"begin":603,"end":605},"obj":"VB"},{"id":"T3273","span":{"begin":601,"end":602},"obj":"-COMMA-"},{"id":"T3272","span":{"begin":593,"end":601},"obj":"NN"},{"id":"T3271","span":{"begin":591,"end":592},"obj":"-COMMA-"},{"id":"T3270","span":{"begin":582,"end":591},"obj":"NN"},{"id":"T3269","span":{"begin":570,"end":581},"obj":"NN"},{"id":"T3268","span":{"begin":566,"end":569},"obj":"DT"},{"id":"T3267","span":{"begin":560,"end":565},"obj":"VB"},{"id":"T3266","span":{"begin":557,"end":559},"obj":"IN"},{"id":"T3265","span":{"begin":554,"end":556},"obj":"CC"},{"id":"T3264","span":{"begin":544,"end":553},"obj":"NN"},{"id":"T3263","span":{"begin":538,"end":543},"obj":"NN"},{"id":"T3262","span":{"begin":530,"end":537},"obj":"IN"},{"id":"T3261","span":{"begin":523,"end":529},"obj":"CC"},{"id":"T3260","span":{"begin":521,"end":522},"obj":"-COMMA-"},{"id":"T3259","span":{"begin":516,"end":521},"obj":"RB"},{"id":"T3258","span":{"begin":507,"end":515},"obj":"NN"},{"id":"T3257","span":{"begin":497,"end":506},"obj":"NN"},{"id":"T3256","span":{"begin":494,"end":496},"obj":"IN"},{"id":"T3255","span":{"begin":483,"end":493},"obj":"NN"},{"id":"T3254","span":{"begin":481,"end":482},"obj":"-COMMA-"},{"id":"T3253","span":{"begin":473,"end":481},"obj":"NN"},{"id":"T3252","span":{"begin":470,"end":472},"obj":"IN"},{"id":"T3251","span":{"begin":467,"end":468},"obj":"-RRB-"},{"id":"T3250","span":{"begin":465,"end":467},"obj":"CD"},{"id":"T3249","span":{"begin":464,"end":465},"obj":"-LRB-"},{"id":"T3248","span":{"begin":462,"end":463},"obj":"-COMMA-"},{"id":"T3247","span":{"begin":461,"end":462},"obj":"-RRB-"},{"id":"T3246","span":{"begin":459,"end":461},"obj":"CD"},{"id":"T3245","span":{"begin":458,"end":459},"obj":"-LRB-"},{"id":"T3244","span":{"begin":453,"end":457},"obj":"NN"},{"id":"T3243","span":{"begin":448,"end":452},"obj":"IN"},{"id":"T3242","span":{"begin":436,"end":447},"obj":"NN"},{"id":"T3241","span":{"begin":426,"end":435},"obj":"VB"},{"id":"T3240","span":{"begin":420,"end":425},"obj":"NN"},{"id":"T3239","span":{"begin":415,"end":419},"obj":"NN"},{"id":"T3238","span":{"begin":403,"end":414},"obj":"JJ"},{"id":"T3237","span":{"begin":395,"end":402},"obj":"VB"},{"id":"T3236","span":{"begin":389,"end":394},"obj":"NN"},{"id":"T3235","span":{"begin":384,"end":388},"obj":"NN"},{"id":"T3234","span":{"begin":371,"end":383},"obj":"NN"},{"id":"T3233","span":{"begin":365,"end":370},"obj":"NN"},{"id":"T3232","span":{"begin":360,"end":364},"obj":"IN"},{"id":"T3231","span":{"begin":348,"end":359},"obj":"VB"},{"id":"T3230","span":{"begin":343,"end":347},"obj":"VB"},{"id":"T3229","span":{"begin":339,"end":342},"obj":"VB"},{"id":"T3228","span":{"begin":336,"end":338},"obj":"PRP"},{"id":"T3227","span":{"begin":330,"end":335},"obj":"NN"},{"id":"T3226","span":{"begin":325,"end":329},"obj":"NN"},{"id":"T3225","span":{"begin":322,"end":324},"obj":"IN"},{"id":"T3224","span":{"begin":310,"end":321},"obj":"NNP"},{"id":"T3223","span":{"begin":301,"end":309},"obj":"NNP"},{"id":"T3222","span":{"begin":294,"end":300},"obj":"NNP"},{"id":"T3221","span":{"begin":287,"end":293},"obj":"NNP"},{"id":"T3220","span":{"begin":276,"end":286},"obj":"NN"},{"id":"T1749","span":{"begin":249,"end":258},"obj":"NN"},{"id":"T1748","span":{"begin":236,"end":248},"obj":"JJ"},{"id":"T1747","span":{"begin":216,"end":235},"obj":"JJ"},{"id":"T1746","span":{"begin":212,"end":215},"obj":"CC"},{"id":"T1745","span":{"begin":203,"end":211},"obj":"NN"},{"id":"T1744","span":{"begin":193,"end":202},"obj":"VB"},{"id":"T1743","span":{"begin":190,"end":192},"obj":"IN"},{"id":"T1742","span":{"begin":182,"end":189},"obj":"NN"},{"id":"T1741","span":{"begin":178,"end":181},"obj":"NN"},{"id":"T1740","span":{"begin":174,"end":177},"obj":"DT"},{"id":"T1739","span":{"begin":170,"end":173},"obj":"IN"},{"id":"T1738","span":{"begin":165,"end":169},"obj":"NN"},{"id":"T1737","span":{"begin":159,"end":164},"obj":"JJ"},{"id":"T1736","span":{"begin":155,"end":158},"obj":"CC"},{"id":"T1735","span":{"begin":146,"end":154},"obj":"JJ"},{"id":"T1734","span":{"begin":144,"end":145},"obj":"DT"},{"id":"T1733","span":{"begin":137,"end":143},"obj":"VB"},{"id":"T1732","span":{"begin":129,"end":136},"obj":"NN"},{"id":"T1731","span":{"begin":125,"end":128},"obj":"PRP-DOLLAR-"},{"id":"T1730","span":{"begin":123,"end":124},"obj":"-COMMA-"},{"id":"T1729","span":{"begin":116,"end":123},"obj":"RB"},{"id":"T1728","span":{"begin":112,"end":114},"obj":"FW"},{"id":"T1727","span":{"begin":108,"end":111},"obj":"FW"},{"id":"T1726","span":{"begin":102,"end":107},"obj":"NN"},{"id":"T1725","span":{"begin":97,"end":101},"obj":"NN"},{"id":"T1724","span":{"begin":93,"end":96},"obj":"IN"},{"id":"T1723","span":{"begin":81,"end":92},"obj":"JJ"},{"id":"T1722","span":{"begin":78,"end":80},"obj":"VB"},{"id":"T1721","span":{"begin":74,"end":77},"obj":"CC"},{"id":"T1720","span":{"begin":72,"end":73},"obj":"-COMMA-"},{"id":"T1719","span":{"begin":62,"end":72},"obj":"NN"},{"id":"T1718","span":{"begin":57,"end":61},"obj":"NN"},{"id":"T1717","span":{"begin":54,"end":56},"obj":"TO"},{"id":"T1716","span":{"begin":49,"end":53},"obj":"NN"},{"id":"T1715","span":{"begin":45,"end":48},"obj":"JJ"},{"id":"T1714","span":{"begin":43,"end":44},"obj":"DT"},{"id":"T1713","span":{"begin":34,"end":42},"obj":"VB"},{"id":"T1712","span":{"begin":30,"end":33},"obj":"NN"},{"id":"T1711","span":{"begin":18,"end":29},"obj":"NN"},{"id":"T1710","span":{"begin":13,"end":17},"obj":"NN"},{"id":"T1709","span":{"begin":7,"end":12},"obj":"NN"},{"id":"T1708","span":{"begin":3,"end":6},"obj":"CC"},{"id":"T1707","span":{"begin":1,"end":2},"obj":"-COMMA-"},{"id":"T3219","span":{"begin":270,"end":275},"obj":"JJ"}],"relations":[{"id":"R1155","pred":"arg1Of","subj":"T1708","obj":"T1707"},{"id":"R1156","pred":"arg1Of","subj":"T1708","obj":"T1713"},{"id":"R1157","pred":"arg2Of","subj":"T1712","obj":"T1708"},{"id":"R1158","pred":"arg1Of","subj":"T1712","obj":"T1709"},{"id":"R1159","pred":"arg1Of","subj":"T1712","obj":"T1710"},{"id":"R1160","pred":"arg1Of","subj":"T1712","obj":"T1711"},{"id":"R1165","pred":"arg2Of","subj":"T1716","obj":"T1713"},{"id":"R1166","pred":"arg1Of","subj":"T1716","obj":"T1714"},{"id":"R1167","pred":"arg1Of","subj":"T1716","obj":"T1715"},{"id":"R1168","pred":"arg1Of","subj":"T1716","obj":"T1717"},{"id":"R1169","pred":"arg2Of","subj":"T1719","obj":"T1717"},{"id":"R1170","pred":"arg1Of","subj":"T1719","obj":"T1718"},{"id":"R1171","pred":"arg1Of","subj":"T1721","obj":"T1720"},{"id":"R1172","pred":"arg2Of","subj":"T1722","obj":"T1721"},{"id":"R1173","pred":"arg1Of","subj":"T1722","obj":"T1728"},{"id":"R1174","pred":"arg2Of","subj":"T1723","obj":"T1722"},{"id":"R1175","pred":"arg1Of","subj":"T1723","obj":"T1724"},{"id":"R1176","pred":"arg2Of","subj":"T1726","obj":"T1724"},{"id":"R1177","pred":"arg1Of","subj":"T1726","obj":"T1725"},{"id":"R1178","pred":"arg1Of","subj":"T1728","obj":"T1727"},{"id":"R1179","pred":"arg1Of","subj":"T1732","obj":"T1731"},{"id":"R1180","pred":"arg1Of","subj":"T1732","obj":"T1733"},{"id":"R1181","pred":"arg1Of","subj":"T1733","obj":"T1729"},{"id":"R1182","pred":"arg1Of","subj":"T1733","obj":"T1730"},{"id":"R1183","pred":"arg1Of","subj":"T1735","obj":"T1736"},{"id":"R1184","pred":"arg2Of","subj":"T1737","obj":"T1736"},{"id":"R1185","pred":"arg2Of","subj":"T1738","obj":"T1733"},{"id":"R1186","pred":"arg1Of","subj":"T1738","obj":"T1734"},{"id":"R1187","pred":"arg1Of","subj":"T1738","obj":"T1735"},{"id":"R1188","pred":"arg1Of","subj":"T1738","obj":"T1737"},{"id":"R1189","pred":"arg1Of","subj":"T1738","obj":"T1739"},{"id":"R1190","pred":"arg1Of","subj":"T1738","obj":"T1743"},{"id":"R1191","pred":"arg2Of","subj":"T1742","obj":"T1739"},{"id":"R1192","pred":"arg1Of","subj":"T1742","obj":"T1740"},{"id":"R1193","pred":"arg1Of","subj":"T1742","obj":"T1741"},{"id":"R1194","pred":"arg2Of","subj":"T1745","obj":"T1744"},{"id":"R1195","pred":"arg1Of","subj":"T1745","obj":"T1746"},{"id":"R1196","pred":"arg2Of","subj":"T1746","obj":"T1743"},{"id":"R1197","pred":"arg2Of","subj":"T1749","obj":"T1746"},{"id":"R1198","pred":"arg1Of","subj":"T1749","obj":"T1747"},{"id":"R1199","pred":"arg1Of","subj":"T1749","obj":"T1748"},{"id":"R2033","pred":"arg1Of","subj":"T3237","obj":"T3248"},{"id":"R2034","pred":"arg1Of","subj":"T3237","obj":"T3249"},{"id":"R2042","pred":"arg2Of","subj":"T3246","obj":"T3245"},{"id":"R2043","pred":"arg3Of","subj":"T3247","obj":"T3245"},{"id":"R2044","pred":"arg2Of","subj":"T3250","obj":"T3249"},{"id":"R2045","pred":"arg3Of","subj":"T3251","obj":"T3249"},{"id":"R2046","pred":"arg2Of","subj":"T3253","obj":"T3252"},{"id":"R2047","pred":"arg1Of","subj":"T3255","obj":"T3256"},{"id":"R2048","pred":"arg1Of","subj":"T3255","obj":"T3274"},{"id":"R2049","pred":"arg1Of","subj":"T3255","obj":"T3275"},{"id":"R2050","pred":"arg1Of","subj":"T3255","obj":"T3277"},{"id":"R2051","pred":"arg2Of","subj":"T3258","obj":"T3256"},{"id":"R2052","pred":"arg1Of","subj":"T3258","obj":"T3257"},{"id":"R2053","pred":"arg1Of","subj":"T3258","obj":"T3259"},{"id":"R2054","pred":"arg1Of","subj":"T3262","obj":"T3265"},{"id":"R2055","pred":"arg2Of","subj":"T3264","obj":"T3262"},{"id":"R2056","pred":"arg1Of","subj":"T3264","obj":"T3263"},{"id":"R2057","pred":"arg1Of","subj":"T3265","obj":"T3261"},{"id":"R2058","pred":"arg2Of","subj":"T3266","obj":"T3265"},{"id":"R2059","pred":"arg2Of","subj":"T3267","obj":"T3266"},{"id":"R2060","pred":"arg2Of","subj":"T3270","obj":"T3267"},{"id":"R2061","pred":"arg1Of","subj":"T3270","obj":"T3268"},{"id":"R2062","pred":"arg1Of","subj":"T3270","obj":"T3269"},{"id":"R2063","pred":"arg1Of","subj":"T3270","obj":"T3271"},{"id":"R2064","pred":"arg2Of","subj":"T3272","obj":"T3271"},{"id":"R2065","pred":"arg1Of","subj":"T3274","obj":"T3252"},{"id":"R2066","pred":"arg1Of","subj":"T3274","obj":"T3254"},{"id":"R2067","pred":"arg1Of","subj":"T3274","obj":"T3260"},{"id":"R2068","pred":"arg1Of","subj":"T3274","obj":"T3262"},{"id":"R2069","pred":"arg1Of","subj":"T3274","obj":"T3266"},{"id":"R2070","pred":"arg1Of","subj":"T3274","obj":"T3273"},{"id":"R2071","pred":"arg2Of","subj":"T3275","obj":"T3274"},{"id":"R2072","pred":"arg2Of","subj":"T3277","obj":"T3275"},{"id":"R2073","pred":"arg1Of","subj":"T3277","obj":"T3276"},{"id":"R2013","pred":"arg1Of","subj":"T3224","obj":"T3219"},{"id":"R2014","pred":"arg1Of","subj":"T3224","obj":"T3220"},{"id":"R2015","pred":"arg1Of","subj":"T3224","obj":"T3221"},{"id":"R2016","pred":"arg1Of","subj":"T3224","obj":"T3222"},{"id":"R2017","pred":"arg1Of","subj":"T3224","obj":"T3223"},{"id":"R2018","pred":"arg1Of","subj":"T3224","obj":"T3225"},{"id":"R2019","pred":"arg2Of","subj":"T3227","obj":"T3225"},{"id":"R2020","pred":"arg1Of","subj":"T3227","obj":"T3226"},{"id":"R2021","pred":"arg1Of","subj":"T3228","obj":"T3229"},{"id":"R2022","pred":"arg1Of","subj":"T3228","obj":"T3230"},{"id":"R2023","pred":"arg2Of","subj":"T3228","obj":"T3231"},{"id":"R2024","pred":"arg2Of","subj":"T3231","obj":"T3229"},{"id":"R2025","pred":"arg2Of","subj":"T3231","obj":"T3230"},{"id":"R2026","pred":"arg1Of","subj":"T3236","obj":"T3233"},{"id":"R2027","pred":"arg1Of","subj":"T3236","obj":"T3234"},{"id":"R2028","pred":"arg1Of","subj":"T3236","obj":"T3235"},{"id":"R2029","pred":"arg1Of","subj":"T3236","obj":"T3237"},{"id":"R2030","pred":"arg3Of","subj":"T3237","obj":"T3231"},{"id":"R2031","pred":"arg1Of","subj":"T3237","obj":"T3232"},{"id":"R2032","pred":"arg1Of","subj":"T3237","obj":"T3241"},{"id":"R2035","pred":"arg2Of","subj":"T3240","obj":"T3237"},{"id":"R2036","pred":"arg1Of","subj":"T3240","obj":"T3238"},{"id":"R2037","pred":"arg1Of","subj":"T3240","obj":"T3239"},{"id":"R2038","pred":"arg2Of","subj":"T3242","obj":"T3241"},{"id":"R2039","pred":"arg1Of","subj":"T3242","obj":"T3243"},{"id":"R2040","pred":"arg2Of","subj":"T3244","obj":"T3243"},{"id":"R2041","pred":"arg1Of","subj":"T3244","obj":"T3245"}],"namespaces":[{"prefix":"_base","uri":"http://kmcs.nii.ac.jp/enju/"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T950","span":{"begin":57,"end":61},"obj":"Protein"},{"id":"T3041","span":{"begin":497,"end":506},"obj":"Protein"},{"id":"T3040","span":{"begin":453,"end":457},"obj":"Protein"},{"id":"T3039","span":{"begin":270,"end":300},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T3953","span":{"begin":453,"end":457},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T1842","span":{"begin":178,"end":181},"obj":"http://www.uniprot.org/uniprot/Q9Y243"},{"id":"T1841","span":{"begin":30,"end":33},"obj":"http://www.uniprot.org/uniprot/Q9Y243"},{"id":"T1831","span":{"begin":178,"end":181},"obj":"http://www.uniprot.org/uniprot/P31751"},{"id":"T1830","span":{"begin":30,"end":33},"obj":"http://www.uniprot.org/uniprot/P31751"},{"id":"T1820","span":{"begin":178,"end":181},"obj":"http://www.uniprot.org/uniprot/P31749"},{"id":"T1819","span":{"begin":30,"end":33},"obj":"http://www.uniprot.org/uniprot/P31749"},{"id":"T1809","span":{"begin":57,"end":61},"obj":"http://www.uniprot.org/uniprot/P01375"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"UBERON-AE","denotations":[{"id":"T879","span":{"begin":13,"end":17},"obj":"http://purl.obolibrary.org/obo/UBERON_0002048"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"GO-BP","denotations":[{"id":"T3122","span":{"begin":420,"end":425},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T3117","span":{"begin":415,"end":425},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T3099","span":{"begin":310,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0097528"},{"id":"T3079","span":{"begin":310,"end":321},"obj":"http://purl.obolibrary.org/obo/GO_0070266"},{"id":"T3068","span":{"begin":287,"end":293},"obj":"http://purl.obolibrary.org/obo/GO_0040007"},{"id":"T1048","span":{"begin":193,"end":211},"obj":"http://purl.obolibrary.org/obo/GO_0097300"},{"id":"T1018","span":{"begin":249,"end":258},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T1009","span":{"begin":216,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T1008","span":{"begin":203,"end":211},"obj":"http://purl.obolibrary.org/obo/GO_0070265"},{"id":"T1006","span":{"begin":216,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T1005","span":{"begin":203,"end":211},"obj":"http://purl.obolibrary.org/obo/GO_0019835"},{"id":"T1003","span":{"begin":216,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T1002","span":{"begin":203,"end":211},"obj":"http://purl.obolibrary.org/obo/GO_0001906"},{"id":"T1000","span":{"begin":102,"end":107},"obj":"http://purl.obolibrary.org/obo/GO_0016265"},{"id":"T995","span":{"begin":216,"end":224},"obj":"http://purl.obolibrary.org/obo/GO_0008219"},{"id":"T994","span":{"begin":203,"end":211},"obj":"http://purl.obolibrary.org/obo/GO_0008219"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"GO-CC","denotations":[{"id":"T3162","span":{"begin":389,"end":394},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T1064","span":{"begin":97,"end":101},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"sentences","denotations":[{"id":"T2973","span":{"begin":336,"end":469},"obj":"Sentence"},{"id":"T2972","span":{"begin":270,"end":335},"obj":"Sentence"},{"id":"T901","span":{"begin":116,"end":259},"obj":"Sentence"},{"id":"T35","span":{"begin":116,"end":259},"obj":"Sentence"},{"id":"T36","span":{"begin":261,"end":268},"obj":"Sentence"},{"id":"T37","span":{"begin":270,"end":335},"obj":"Sentence"},{"id":"T38","span":{"begin":336,"end":469},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"simple1","denotations":[{"id":"T3173","span":{"begin":497,"end":506},"obj":"Protein"},{"id":"T3172","span":{"begin":453,"end":457},"obj":"Protein"},{"id":"T3171","span":{"begin":270,"end":300},"obj":"Protein"},{"id":"T1084","span":{"begin":57,"end":61},"obj":"Protein"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"BioNLP16_DUT","denotations":[{"id":"T3946","span":{"begin":483,"end":493},"obj":"Negative_regulation"},{"id":"T1768","span":{"begin":57,"end":61},"obj":"Protein"},{"id":"T3919","span":{"begin":497,"end":506},"obj":"Protein"},{"id":"T3918","span":{"begin":453,"end":457},"obj":"Protein"},{"id":"T3917","span":{"begin":270,"end":300},"obj":"Protein"},{"id":"T1777","span":{"begin":62,"end":72},"obj":"Gene_expression"}],"relations":[{"id":"R1205","pred":"themeOf","subj":"T1768","obj":"T1777"},{"id":"R2718","pred":"themeOf","subj":"T3919","obj":"T3946"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T4077","span":{"begin":483,"end":493},"obj":"Negative_regulation"},{"id":"T4050","span":{"begin":497,"end":506},"obj":"Protein"},{"id":"T4049","span":{"begin":453,"end":457},"obj":"Protein"},{"id":"T4048","span":{"begin":270,"end":300},"obj":"Protein"},{"id":"T2152","span":{"begin":62,"end":72},"obj":"Gene_expression"},{"id":"T2151","span":{"begin":49,"end":53},"obj":"Positive_regulation"},{"id":"T2140","span":{"begin":57,"end":61},"obj":"Protein"}],"relations":[{"id":"R1462","pred":"themeOf","subj":"T2140","obj":"T2152"},{"id":"R1471","pred":"themeOf","subj":"T2152","obj":"T2151"},{"id":"R2745","pred":"themeOf","subj":"T4050","obj":"T4077"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"DLUT931","denotations":[{"id":"T4004","span":{"begin":544,"end":553},"obj":"Negative_regulation"},{"id":"T4003","span":{"begin":483,"end":493},"obj":"Negative_regulation"},{"id":"T3976","span":{"begin":497,"end":506},"obj":"Protein"},{"id":"T3975","span":{"begin":453,"end":457},"obj":"Protein"},{"id":"T3974","span":{"begin":270,"end":300},"obj":"Protein"},{"id":"T1901","span":{"begin":49,"end":53},"obj":"Positive_regulation"},{"id":"T1900","span":{"begin":62,"end":72},"obj":"Gene_expression"},{"id":"T1887","span":{"begin":57,"end":61},"obj":"Protein"}],"relations":[{"id":"R2738","pred":"themeOf","subj":"T4003","obj":"T4004"},{"id":"R1222","pred":"themeOf","subj":"T1887","obj":"T1900"},{"id":"R1229","pred":"themeOf","subj":"T1900","obj":"T1901"},{"id":"R2725","pred":"themeOf","subj":"T3976","obj":"T4003"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T4934","span":{"begin":593,"end":602},"obj":"Entity"},{"id":"T4933","span":{"begin":566,"end":592},"obj":"Protein"},{"id":"T4918","span":{"begin":270,"end":300},"obj":"Protein"},{"id":"T4985","span":{"begin":473,"end":515},"obj":"Negative_regulation"},{"id":"T4984","span":{"begin":270,"end":301},"obj":"Localization"},{"id":"T4976","span":{"begin":276,"end":286},"obj":"Entity"},{"id":"T4974","span":{"begin":453,"end":468},"obj":"Protein"},{"id":"T4964","span":{"begin":566,"end":592},"obj":"Entity"},{"id":"T4951","span":{"begin":497,"end":506},"obj":"Protein"},{"id":"T2797","span":{"begin":57,"end":72},"obj":"Gene_expression"},{"id":"T2789","span":{"begin":30,"end":33},"obj":"Protein"},{"id":"T2766","span":{"begin":57,"end":61},"obj":"Protein"},{"id":"T2761","span":{"begin":174,"end":189},"obj":"Protein"},{"id":"T2751","span":{"begin":7,"end":29},"obj":"Entity"}],"relations":[{"id":"R3458","pred":"themeOf","subj":"T4918","obj":"T4984"},{"id":"R3492","pred":"locationOf","subj":"T4976","obj":"T4984"},{"id":"R1971","pred":"themeOf","subj":"T2766","obj":"T2797"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"bionlp-st-ge-2016-spacy-parsed","denotations":[{"id":"T4199","span":{"begin":620,"end":627},"obj":"VB"},{"id":"T4198","span":{"begin":617,"end":619},"obj":"TO"},{"id":"T4197","span":{"begin":606,"end":616},"obj":"JJ"},{"id":"T4196","span":{"begin":603,"end":605},"obj":"VBZ"},{"id":"T4195","span":{"begin":601,"end":602},"obj":","},{"id":"T4194","span":{"begin":593,"end":601},"obj":"NNP"},{"id":"T4193","span":{"begin":591,"end":592},"obj":","},{"id":"T4192","span":{"begin":582,"end":591},"obj":"NN"},{"id":"T4191","span":{"begin":570,"end":581},"obj":"NN"},{"id":"T4190","span":{"begin":566,"end":569},"obj":"DT"},{"id":"T4189","span":{"begin":560,"end":565},"obj":"VBG"},{"id":"T4188","span":{"begin":557,"end":559},"obj":"IN"},{"id":"T4187","span":{"begin":554,"end":556},"obj":"CC"},{"id":"T4186","span":{"begin":544,"end":553},"obj":"NN"},{"id":"T4185","span":{"begin":538,"end":543},"obj":"NNP"},{"id":"T4184","span":{"begin":530,"end":537},"obj":"IN"},{"id":"T4183","span":{"begin":523,"end":529},"obj":"DT"},{"id":"T4182","span":{"begin":521,"end":522},"obj":","},{"id":"T4181","span":{"begin":516,"end":521},"obj":"RB"},{"id":"T4180","span":{"begin":507,"end":515},"obj":"NN"},{"id":"T4179","span":{"begin":497,"end":506},"obj":"JJ"},{"id":"T4178","span":{"begin":494,"end":496},"obj":"IN"},{"id":"T4177","span":{"begin":483,"end":493},"obj":"NN"},{"id":"T4176","span":{"begin":481,"end":482},"obj":","},{"id":"T4175","span":{"begin":473,"end":481},"obj":"NN"},{"id":"T4174","span":{"begin":470,"end":472},"obj":"IN"},{"id":"T4173","span":{"begin":468,"end":469},"obj":"."},{"id":"T4172","span":{"begin":467,"end":468},"obj":"NNP"},{"id":"T4171","span":{"begin":465,"end":467},"obj":"CD"},{"id":"T4170","span":{"begin":464,"end":465},"obj":"NNP"},{"id":"T4169","span":{"begin":462,"end":463},"obj":","},{"id":"T4168","span":{"begin":461,"end":462},"obj":"NNP"},{"id":"T4167","span":{"begin":459,"end":461},"obj":"CD"},{"id":"T4166","span":{"begin":458,"end":459},"obj":"NNP"},{"id":"T4165","span":{"begin":453,"end":457},"obj":"NNP"},{"id":"T4164","span":{"begin":448,"end":452},"obj":"IN"},{"id":"T4163","span":{"begin":436,"end":447},"obj":"NN"},{"id":"T4162","span":{"begin":426,"end":435},"obj":"VBG"},{"id":"T4161","span":{"begin":420,"end":425},"obj":"NN"},{"id":"T4160","span":{"begin":415,"end":419},"obj":"NN"},{"id":"T4159","span":{"begin":403,"end":414},"obj":"JJ"},{"id":"T4158","span":{"begin":395,"end":402},"obj":"VBP"},{"id":"T4157","span":{"begin":389,"end":394},"obj":"NNS"},{"id":"T4156","span":{"begin":384,"end":388},"obj":"NNP"},{"id":"T4155","span":{"begin":371,"end":383},"obj":"NN"},{"id":"T4154","span":{"begin":365,"end":370},"obj":"NN"},{"id":"T4153","span":{"begin":360,"end":364},"obj":"IN"},{"id":"T4152","span":{"begin":348,"end":359},"obj":"VBN"},{"id":"T4151","span":{"begin":343,"end":347},"obj":"VBN"},{"id":"T4150","span":{"begin":339,"end":342},"obj":"VBZ"},{"id":"T4149","span":{"begin":336,"end":338},"obj":"PRP"},{"id":"T4148","span":{"begin":330,"end":335},"obj":"NNP"},{"id":"T4147","span":{"begin":325,"end":329},"obj":"NNP"},{"id":"T4146","span":{"begin":322,"end":324},"obj":"IN"},{"id":"T4145","span":{"begin":310,"end":321},"obj":"NNP"},{"id":"T4144","span":{"begin":301,"end":309},"obj":"NNP"},{"id":"T4143","span":{"begin":294,"end":300},"obj":"NNP"},{"id":"T4142","span":{"begin":287,"end":293},"obj":"NNP"},{"id":"T4141","span":{"begin":276,"end":286},"obj":"NNP"},{"id":"T4140","span":{"begin":270,"end":275},"obj":"JJ"},{"id":"T2673","span":{"begin":258,"end":259},"obj":"."},{"id":"T2672","span":{"begin":249,"end":258},"obj":"VBG"},{"id":"T2671","span":{"begin":236,"end":248},"obj":"JJ"},{"id":"T2670","span":{"begin":216,"end":235},"obj":"JJ"},{"id":"T2669","span":{"begin":212,"end":215},"obj":"CC"},{"id":"T2668","span":{"begin":203,"end":211},"obj":"NN"},{"id":"T2667","span":{"begin":193,"end":202},"obj":"JJ"},{"id":"T2666","span":{"begin":190,"end":192},"obj":"IN"},{"id":"T2665","span":{"begin":182,"end":189},"obj":"NN"},{"id":"T2664","span":{"begin":178,"end":181},"obj":"NNP"},{"id":"T2663","span":{"begin":174,"end":177},"obj":"DT"},{"id":"T2662","span":{"begin":170,"end":173},"obj":"IN"},{"id":"T2661","span":{"begin":165,"end":169},"obj":"NN"},{"id":"T2660","span":{"begin":159,"end":164},"obj":"JJ"},{"id":"T2659","span":{"begin":155,"end":158},"obj":"CC"},{"id":"T2658","span":{"begin":146,"end":154},"obj":"JJ"},{"id":"T2657","span":{"begin":144,"end":145},"obj":"DT"},{"id":"T2656","span":{"begin":137,"end":143},"obj":"VBP"},{"id":"T2655","span":{"begin":129,"end":136},"obj":"NNS"},{"id":"T2654","span":{"begin":125,"end":128},"obj":"PRP$"},{"id":"T2653","span":{"begin":123,"end":124},"obj":","},{"id":"T2652","span":{"begin":116,"end":123},"obj":"RB"},{"id":"T2651","span":{"begin":114,"end":115},"obj":"."},{"id":"T2650","span":{"begin":112,"end":114},"obj":"FW"},{"id":"T2649","span":{"begin":108,"end":111},"obj":"IN"},{"id":"T2648","span":{"begin":102,"end":107},"obj":"NN"},{"id":"T2647","span":{"begin":97,"end":101},"obj":"NN"},{"id":"T2646","span":{"begin":93,"end":96},"obj":"IN"},{"id":"T2645","span":{"begin":81,"end":92},"obj":"JJ"},{"id":"T2644","span":{"begin":78,"end":80},"obj":"VBZ"},{"id":"T2643","span":{"begin":74,"end":77},"obj":"CC"},{"id":"T2642","span":{"begin":72,"end":73},"obj":","},{"id":"T2641","span":{"begin":62,"end":72},"obj":"NN"},{"id":"T2640","span":{"begin":57,"end":61},"obj":"VB"},{"id":"T2639","span":{"begin":54,"end":56},"obj":"TO"},{"id":"T2638","span":{"begin":49,"end":53},"obj":"NN"},{"id":"T2637","span":{"begin":45,"end":48},"obj":"JJ"},{"id":"T2636","span":{"begin":43,"end":44},"obj":"DT"},{"id":"T2635","span":{"begin":34,"end":42},"obj":"VBZ"},{"id":"T2634","span":{"begin":30,"end":33},"obj":"NNP"},{"id":"T2633","span":{"begin":18,"end":29},"obj":"NNS"},{"id":"T2632","span":{"begin":13,"end":17},"obj":"NN"},{"id":"T2631","span":{"begin":7,"end":12},"obj":"NN"},{"id":"T2630","span":{"begin":3,"end":6},"obj":"CC"},{"id":"T2629","span":{"begin":1,"end":2},"obj":","}],"relations":[{"id":"R1916","pred":"compound","subj":"T2631","obj":"T2632"},{"id":"R1917","pred":"compound","subj":"T2632","obj":"T2633"},{"id":"R1921","pred":"nsubj","subj":"T2634","obj":"T2635"},{"id":"R1927","pred":"det","subj":"T2636","obj":"T2638"},{"id":"R1929","pred":"amod","subj":"T2637","obj":"T2638"},{"id":"R1930","pred":"dobj","subj":"T2638","obj":"T2635"},{"id":"R1932","pred":"aux","subj":"T2639","obj":"T2640"},{"id":"R1933","pred":"relcl","subj":"T2640","obj":"T2638"},{"id":"R1934","pred":"dobj","subj":"T2641","obj":"T2640"},{"id":"R1943","pred":"acomp","subj":"T2645","obj":"T2644"},{"id":"R1944","pred":"prep","subj":"T2646","obj":"T2645"},{"id":"R1945","pred":"compound","subj":"T2647","obj":"T2648"},{"id":"R1946","pred":"pobj","subj":"T2648","obj":"T2646"},{"id":"R1947","pred":"prep","subj":"T2649","obj":"T2648"},{"id":"R1948","pred":"pobj","subj":"T2650","obj":"T2649"},{"id":"R1950","pred":"advmod","subj":"T2652","obj":"T2656"},{"id":"R1951","pred":"punct","subj":"T2653","obj":"T2656"},{"id":"R1952","pred":"poss","subj":"T2654","obj":"T2655"},{"id":"R1954","pred":"nsubj","subj":"T2655","obj":"T2656"},{"id":"R1956","pred":"ROOT","subj":"T2656","obj":"T2656"},{"id":"R1957","pred":"det","subj":"T2657","obj":"T2661"},{"id":"R1958","pred":"amod","subj":"T2658","obj":"T2661"},{"id":"R1960","pred":"cc","subj":"T2659","obj":"T2658"},{"id":"R1961","pred":"conj","subj":"T2660","obj":"T2658"},{"id":"R1963","pred":"dobj","subj":"T2661","obj":"T2656"},{"id":"R1965","pred":"prep","subj":"T2662","obj":"T2661"},{"id":"R1966","pred":"det","subj":"T2663","obj":"T2665"},{"id":"R1967","pred":"compound","subj":"T2664","obj":"T2665"},{"id":"R1968","pred":"pobj","subj":"T2665","obj":"T2662"},{"id":"R1970","pred":"prep","subj":"T2666","obj":"T2665"},{"id":"R1972","pred":"amod","subj":"T2667","obj":"T2668"},{"id":"R1974","pred":"pobj","subj":"T2668","obj":"T2666"},{"id":"R1975","pred":"cc","subj":"T2669","obj":"T2668"},{"id":"R1977","pred":"amod","subj":"T2670","obj":"T2672"},{"id":"R1979","pred":"amod","subj":"T2671","obj":"T2672"},{"id":"R1980","pred":"advcl","subj":"T2672","obj":"T2656"},{"id":"R1981","pred":"punct","subj":"T2673","obj":"T2656"},{"id":"R2760","pred":"compound","subj":"T4140","obj":"T4143"},{"id":"R2761","pred":"compound","subj":"T4141","obj":"T4143"},{"id":"R2762","pred":"compound","subj":"T4142","obj":"T4143"},{"id":"R2763","pred":"compound","subj":"T4143","obj":"T4145"},{"id":"R2764","pred":"compound","subj":"T4144","obj":"T4145"},{"id":"R2765","pred":"ROOT","subj":"T4145","obj":"T4145"},{"id":"R2766","pred":"prep","subj":"T4146","obj":"T4145"},{"id":"R2767","pred":"compound","subj":"T4147","obj":"T4148"},{"id":"R2768","pred":"pobj","subj":"T4148","obj":"T4146"},{"id":"R2769","pred":"nsubjpass","subj":"T4149","obj":"T4152"},{"id":"R2770","pred":"aux","subj":"T4150","obj":"T4152"},{"id":"R2771","pred":"auxpass","subj":"T4151","obj":"T4152"},{"id":"R2772","pred":"ROOT","subj":"T4152","obj":"T4152"},{"id":"R2773","pred":"mark","subj":"T4153","obj":"T4158"},{"id":"R2774","pred":"compound","subj":"T4154","obj":"T4157"},{"id":"R2775","pred":"compound","subj":"T4155","obj":"T4156"},{"id":"R2776","pred":"compound","subj":"T4156","obj":"T4157"},{"id":"R2777","pred":"nsubj","subj":"T4157","obj":"T4158"},{"id":"R2778","pred":"ccomp","subj":"T4158","obj":"T4152"},{"id":"R2779","pred":"amod","subj":"T4159","obj":"T4163"},{"id":"R2780","pred":"compound","subj":"T4160","obj":"T4161"},{"id":"R2781","pred":"npadvmod","subj":"T4161","obj":"T4162"},{"id":"R2782","pred":"amod","subj":"T4162","obj":"T4163"},{"id":"R2783","pred":"dobj","subj":"T4163","obj":"T4158"},{"id":"R2784","pred":"prep","subj":"T4164","obj":"T4158"},{"id":"R2785","pred":"compound","subj":"T4165","obj":"T4166"},{"id":"R2786","pred":"pobj","subj":"T4166","obj":"T4164"},{"id":"R2787","pred":"nummod","subj":"T4167","obj":"T4168"},{"id":"R2788","pred":"conj","subj":"T4168","obj":"T4166"},{"id":"R2789","pred":"punct","subj":"T4169","obj":"T4168"},{"id":"R2790","pred":"nmod","subj":"T4170","obj":"T4172"},{"id":"R2791","pred":"nummod","subj":"T4171","obj":"T4172"},{"id":"R2792","pred":"conj","subj":"T4172","obj":"T4168"},{"id":"R2793","pred":"punct","subj":"T4173","obj":"T4152"},{"id":"R2794","pred":"prep","subj":"T4174","obj":"T4196"},{"id":"R2795","pred":"pobj","subj":"T4175","obj":"T4174"},{"id":"R2796","pred":"punct","subj":"T4176","obj":"T4196"},{"id":"R2797","pred":"nsubj","subj":"T4177","obj":"T4196"},{"id":"R2798","pred":"prep","subj":"T4178","obj":"T4177"},{"id":"R2799","pred":"amod","subj":"T4179","obj":"T4180"},{"id":"R2800","pred":"pobj","subj":"T4180","obj":"T4178"},{"id":"R2801","pred":"advmod","subj":"T4181","obj":"T4180"},{"id":"R2802","pred":"punct","subj":"T4182","obj":"T4196"},{"id":"R2803","pred":"advcl","subj":"T4183","obj":"T4196"},{"id":"R2804","pred":"prep","subj":"T4184","obj":"T4183"},{"id":"R2805","pred":"compound","subj":"T4185","obj":"T4186"},{"id":"R2806","pred":"pobj","subj":"T4186","obj":"T4184"},{"id":"R2807","pred":"cc","subj":"T4187","obj":"T4184"},{"id":"R2808","pred":"conj","subj":"T4188","obj":"T4184"},{"id":"R2809","pred":"pcomp","subj":"T4189","obj":"T4188"},{"id":"R2810","pred":"det","subj":"T4190","obj":"T4192"},{"id":"R2811","pred":"compound","subj":"T4191","obj":"T4192"},{"id":"R2812","pred":"dobj","subj":"T4192","obj":"T4189"},{"id":"R2813","pred":"punct","subj":"T4193","obj":"T4196"},{"id":"R2814","pred":"nsubj","subj":"T4194","obj":"T4196"},{"id":"R2815","pred":"punct","subj":"T4195","obj":"T4196"},{"id":"R2816","pred":"ROOT","subj":"T4196","obj":"T4196"},{"id":"R2817","pred":"acomp","subj":"T4197","obj":"T4196"},{"id":"R2818","pred":"aux","subj":"T4198","obj":"T4199"},{"id":"R2819","pred":"xcomp","subj":"T4199","obj":"T4197"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T4086","span":{"begin":593,"end":601},"obj":"Protein"},{"id":"T4085","span":{"begin":574,"end":581},"obj":"Protein"},{"id":"T4084","span":{"begin":497,"end":504},"obj":"Protein"},{"id":"T4083","span":{"begin":453,"end":462},"obj":"Protein"},{"id":"T2205","span":{"begin":178,"end":181},"obj":"Protein"},{"id":"T2204","span":{"begin":62,"end":72},"obj":"Gene_expression"},{"id":"T2203","span":{"begin":57,"end":61},"obj":"Protein"}],"relations":[{"id":"R1488","pred":"themeOf","subj":"T2203","obj":"T2204"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}

{"project":"test3","denotations":[{"id":"T2896","span":{"begin":497,"end":506},"obj":"Protein"},{"id":"T2895","span":{"begin":453,"end":457},"obj":"Protein"},{"id":"T2894","span":{"begin":270,"end":300},"obj":"Protein"},{"id":"T2926","span":{"begin":497,"end":506},"obj":"Protein"},{"id":"T2925","span":{"begin":453,"end":457},"obj":"Protein"},{"id":"T2924","span":{"begin":426,"end":435},"obj":"Positive_regulation"},{"id":"T2923","span":{"begin":270,"end":300},"obj":"Protein"},{"id":"T874","span":{"begin":62,"end":72},"obj":"Gene_expression"},{"id":"T873","span":{"begin":57,"end":61},"obj":"Protein"},{"id":"T844","span":{"begin":57,"end":61},"obj":"Protein"}],"relations":[{"id":"R512","pred":"themeOf","subj":"T873","obj":"T874"}],"text":"s, and mouse lung fibroblasts Akt provides a key link to TNFα production, but is dispensible for cell death per se. Overall, our results reveal a specific and novel role for the Akt pathway in regulated necrosis and necrosis-associated inflammatory signaling.\n\nResults\n\nBasic Fibroblast Growth Factor Promotes Necroptosis in L929 Cells\nIt has been established that mouse fibrosarcoma L929 cells undergo necroptotic cell death following stimulation with TNFα [10], [17]. In addition, inhibition of caspase-8 activity alone, either through siRNA knockdown or by using the pan-caspase inhibitor, zVAD.fmk, is sufficient to trigger necroptosi"}