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PMC:3585731 / 42882-45183 JSONTXT

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testone

Id Subject Object Predicate Lexical cue
T20788 1186-1201 Phosphorylation denotes phosphorylation
T20787 982-997 Phosphorylation denotes phosphorylation
T20786 725-740 Phosphorylation denotes phosphorylation
T20785 616-625 Regulation denotes targeting
T20784 572-580 Positive_regulation denotes increase
T20783 480-495 Phosphorylation denotes phosphorylation
T20782 445-454 Negative_regulation denotes inhibitor
T20781 426-432 Regulation denotes effect
T20780 192-207 Phosphorylation denotes phosphorylation
T20779 169-177 Positive_regulation denotes increase
T20778 159-168 Regulation denotes dependent
T20777 80-90 Regulation denotes regulation
T20741 2248-2252 Protein denotes TNFα
T20740 2101-2105 Protein denotes TNFα
T20739 1375-1379 Protein denotes TNFα
T20738 1212-1216 Protein denotes RIP1
T20737 880-887 Protein denotes Myr-Akt
T20736 763-767 Protein denotes RIP1
T20735 626-630 Protein denotes PDK1
T20734 604-608 Protein denotes RIP1
T20733 233-237 Protein denotes RIP1
T20732 154-158 Protein denotes RIP1
R13912 T20732 T20778 causeOf RIP1,dependent
R13913 T20734 T20784 themeOf RIP1,increase
R13914 T20736 T20786 causeOf RIP1,phosphorylation
R13915 T20738 T20788 themeOf RIP1,phosphorylation
R13928 T20779 T20778 themeOf increase,dependent
R13929 T20780 T20779 themeOf phosphorylation,increase

2_test

Id Subject Object Predicate Lexical cue
23469174-18006659-90505462 389-391 18006659 denotes 45
23469174-21779001-90505463 1999-2001 21779001 denotes 46

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T21912 2297-2300 NN denotes JNK
T21911 2292-2296 IN denotes with
T21910 2287-2291 NN denotes loop
T21909 2279-2286 RB denotes forward
T21908 2274-2278 NN denotes feed
T21907 2265-2273 JJ denotes positive
T21906 2263-2264 DT denotes a
T21905 2257-2262 VB denotes forms
T21904 2253-2256 CC denotes and
T21903 2248-2252 NN denotes TNFα
T21902 2245-2247 IN denotes of
T21901 2233-2244 NN denotes translation
T21900 2229-2232 DT denotes the
T21899 2226-2228 TO denotes to
T21898 2214-2225 VB denotes contributes
T21897 2207-2213 NN denotes mTORC1
T21896 2202-2206 IN denotes that
T21895 2199-2201 VB denotes is
T21894 2187-2198 NN denotes possibility
T21893 2183-2186 CD denotes one
T21892 2181-2182 -COMMA- denotes ,
T21891 2170-2181 NN denotes necroptosis
T21890 2167-2169 IN denotes in
T21889 2159-2166 NN denotes control
T21888 2145-2158 JJ denotes translational
T21887 2128-2144 JJ denotes mTORC1-dependent
T21886 2125-2127 IN denotes of
T21885 2114-2124 NN denotes importance
T21884 2110-2113 DT denotes the
T21883 2106-2109 CC denotes and
T21882 2101-2105 NN denotes TNFα
T21881 2098-2100 IN denotes by
T21880 2094-2097 NN denotes JNK
T21879 2091-2093 IN denotes of
T21878 2080-2090 NN denotes activation
T21877 2076-2079 DT denotes the
T21876 2070-2075 VB denotes Given
T21875 2057-2068 VB denotes established
T21874 2054-2056 VB denotes be
T21873 2051-2053 TO denotes to
T21872 2044-2050 VB denotes remain
T21871 2032-2043 NN denotes necroptosis
T21870 2025-2031 IN denotes during
T21869 2014-2024 NN denotes mechanisms
T21868 2008-2013 JJ denotes exact
T21867 2004-2007 DT denotes the
T21866 2002-2003 -COMMA- denotes ,
T21865 2001-2002 -RRB- denotes ]
T21864 1999-2001 CD denotes 46
T21863 1998-1999 -LRB- denotes [
T21862 1991-1997 NN denotes stress
T21861 1988-1990 NN denotes ER
T21860 1978-1987 VB denotes following
T21859 1973-1977 FW denotes e.g.
T21858 1971-1972 -COMMA- denotes ,
T21857 1968-1971 NN denotes JNK
T21856 1965-1967 IN denotes of
T21855 1954-1964 NN denotes regulation
T21854 1937-1953 JJ denotes mTORC1-dependent
T21853 1934-1936 IN denotes of
T21852 1925-1933 NN denotes examples
T21851 1918-1924 JJ denotes recent
T21850 1913-1917 DT denotes some
T21849 1909-1912 VB denotes are
T21848 1903-1908 EX denotes there
T21847 1897-1902 IN denotes While
T21846 1885-1895 VB denotes elucidated
T21845 1882-1884 VB denotes be
T21844 1879-1881 TO denotes to
T21843 1872-1878 VB denotes remain
T21842 1868-1871 NN denotes JNK
T21841 1865-1867 TO denotes to
T21840 1858-1864 NN denotes mTORC1
T21839 1847-1857 VB denotes connecting
T21838 1836-1846 NN denotes mechanisms
T21837 1832-1835 DT denotes the
T21836 1830-1831 -COMMA- denotes ,
T21835 1821-1830 RB denotes Similarly
T21834 1808-1819 VB denotes established
T21833 1803-1807 VB denotes been
T21832 1798-1802 VB denotes have
T21831 1786-1797 NN denotes connections
T21830 1781-1785 JJ denotes such
T21829 1778-1780 DT denotes no
T21828 1772-1777 IN denotes since
T21827 1770-1771 -COMMA- denotes ,
T21826 1765-1770 NN denotes death
T21825 1753-1764 JJ denotes necroptotic
T21824 1750-1752 IN denotes in
T21823 1739-1749 NN denotes substrates
T21822 1735-1738 NN denotes Akt
T21821 1724-1734 JJ denotes additional
T21820 1721-1723 IN denotes of
T21819 1715-1720 NN denotes roles
T21818 1711-1714 DT denotes the
T21817 1708-1710 IN denotes of
T21816 1694-1707 NN denotes re-evaluation
T21815 1692-1693 DT denotes a
T21814 1683-1691 VB denotes warrants
T21813 1678-1682 DT denotes This
T21812 1668-1676 VB denotes involved
T21811 1665-1667 VB denotes be
T21810 1662-1664 TO denotes to
T21809 1655-1661 JJ denotes likely
T21808 1651-1654 VB denotes are
T21807 1640-1650 NN denotes substrates
T21806 1636-1639 NN denotes Akt
T21805 1625-1635 JJ denotes additional
T21804 1620-1624 IN denotes that
T21803 1609-1619 VB denotes suggesting
T21802 1607-1608 -COMMA- denotes ,
T21801 1597-1607 NN denotes conditions
T21800 1585-1596 JJ denotes necroptotic
T21799 1579-1584 IN denotes under
T21798 1570-1578 NN denotes activity
T21797 1563-1569 NN denotes mTORC1
T21796 1560-1562 IN denotes in
T21795 1552-1559 NN denotes changes
T21794 1545-1551 JJ denotes modest
T21793 1540-1544 RB denotes only
T21792 1531-1539 VB denotes observed
T21791 1526-1530 VB denotes have
T21790 1523-1525 PRP denotes we
T21789 1521-1522 -COMMA- denotes ,
T21788 1517-1521 NN denotes hand
T21787 1511-1516 JJ denotes other
T21786 1507-1510 DT denotes the
T21785 1504-1506 IN denotes On
T21784 1495-1502 NN denotes control
T21783 1483-1494 JJ denotes necroptotic
T21782 1480-1482 IN denotes in
T21781 1473-1479 NN denotes mTORC1
T21780 1470-1472 IN denotes by
T21779 1461-1469 VB denotes mediated
T21778 1452-1460 NN denotes pathways
T21777 1443-1451 NN denotes effector
T21776 1439-1442 NN denotes Akt
T21775 1435-1438 IN denotes for
T21774 1429-1434 NN denotes roles
T21773 1425-1428 JJ denotes new
T21772 1417-1424 VB denotes suggest
T21771 1412-1416 NN denotes data
T21770 1408-1411 PRP-DOLLAR- denotes our
T21769 1406-1407 -COMMA- denotes ,
T21768 1402-1406 NN denotes hand
T21767 1398-1401 CD denotes one
T21766 1394-1397 DT denotes the
T21765 1391-1393 IN denotes On
T21764 1380-1389 NN denotes synthesis
T21763 1375-1379 NN denotes TNFα
T21762 1371-1374 CC denotes and
T21761 1365-1370 NN denotes death
T21760 1356-1364 JJ denotes necrotic
T21759 1348-1355 VB denotes promote
T21758 1343-1347 WDT denotes that
T21757 1339-1342 NN denotes Akt
T21756 1336-1338 IN denotes of
T21755 1325-1335 NN denotes substrates
T21754 1321-1324 JJ denotes key
T21753 1317-1320 DT denotes the
T21752 1313-1316 VB denotes are
T21751 1308-1312 WP denotes what
T21750 1306-1307 -COMMA- denotes ,
T21749 1300-1306 RB denotes Second
T21748 1288-1298 NN denotes regulation
T21747 1277-1287 JJ denotes endogenous
T21746 1269-1276 VB denotes reflect
T21745 1265-1268 RB denotes not
T21744 1260-1264 VB denotes does
T21743 1256-1259 CC denotes and
T21742 1247-1255 NN denotes artifact
T21741 1241-1246 FW denotes vitro
T21740 1238-1240 FW denotes in
T21739 1235-1237 DT denotes an
T21738 1224-1234 VB denotes represents
T21737 1217-1223 RB denotes likely
T21736 1212-1216 NN denotes RIP1
T21735 1209-1211 IN denotes by
T21734 1205-1208 NN denotes Akt
T21733 1202-1204 IN denotes of
T21732 1186-1201 NN denotes phosphorylation
T21731 1179-1185 JJ denotes direct
T21730 1174-1178 IN denotes that
T21729 1163-1173 VB denotes suggesting
T21680 861-869 NN denotes residues
T21679 855-860 DT denotes these
T21678 846-854 VB denotes mutating
T21677 844-845 -COMMA- denotes ,
T21676 833-844 RB denotes Furthermore
T21675 823-831 NN denotes residues
T21674 816-822 NN denotes Ser381
T21673 812-815 CC denotes and
T21672 808-811 CD denotes 435
T21671 804-807 CC denotes and
T21670 802-803 -COMMA- denotes ,
T21669 795-802 CD denotes 195/197
T21668 793-794 -COMMA- denotes ,
T21667 787-793 NN denotes Thr146
T21666 784-786 IN denotes on
T21665 778-783 FW denotes vitro
T21664 775-777 FW denotes in
T21663 768-774 NN denotes kinase
T21662 763-767 NN denotes RIP1
T21661 751-762 JJ denotes recombinant
T21660 748-750 IN denotes by
T21659 744-747 NN denotes Akt
T21658 741-743 IN denotes of
T21657 725-740 NN denotes phosphorylation
T21656 716-724 VB denotes observed
T21655 713-715 PRP denotes we
T21654 711-712 -COMMA- denotes ,
T21653 698-711 RB denotes Interestingly
T21652 688-696 RB denotes together
T21651 680-687 NN denotes kinases
T21650 676-679 CD denotes two
T21649 670-675 DT denotes these
T21648 664-669 VB denotes bring
T21647 659-663 WDT denotes that
T21646 651-658 NN denotes factors
T21645 639-650 NN denotes scaffolding
T21644 636-638 CC denotes or
T21643 632-635 NN denotes Akt
T21642 630-631 -COMMA- denotes ,
T21641 626-630 NN denotes PDK1
T21640 616-625 VB denotes targeting
T21639 609-615 NN denotes kinase
T21638 604-608 NN denotes RIP1
T21637 599-603 IN denotes from
T21636 591-598 VB denotes results
T21635 584-590 NN denotes Thr308
T21634 581-583 IN denotes in
T21633 572-580 NN denotes increase
T21632 568-571 DT denotes the
T21631 563-567 IN denotes that
T21630 560-562 VB denotes is
T21629 548-559 NN denotes possibility
T21628 540-547 DT denotes Another
T21627 533-538 NN denotes cells
T21626 528-532 NN denotes L929
T21625 525-527 IN denotes in
T21624 513-524 NN denotes necroptosis
T21623 510-512 IN denotes of
T21622 499-509 NN denotes activation
T21621 496-498 CC denotes or
T21620 480-495 NN denotes phosphorylation
T21619 473-479 NN denotes Thr308
T21618 470-472 IN denotes on
T21617 468-469 -COMMA- denotes ,
T21616 464-468 NN denotes acid
T21615 456-463 JJ denotes okadaic
T21614 454-455 -COMMA- denotes ,
T21613 445-454 NN denotes inhibitor
T21612 440-444 NN denotes PP2A
T21611 436-439 DT denotes the
T21610 433-435 IN denotes of
T21609 426-432 NN denotes effect
T21608 422-425 DT denotes any
T21607 414-421 VB denotes observe
T21606 410-413 RB denotes not
T21605 406-409 VB denotes did
T21604 403-405 PRP denotes we
T21603 401-402 -COMMA- denotes ,
T21602 394-401 RB denotes However
T21601 391-392 -RRB- denotes ]
T21600 389-391 CD denotes 45
T21599 388-389 -LRB- denotes [
T21598 380-387 NN denotes residue
T21597 375-379 DT denotes this
T21596 359-374 VB denotes dephosphorylate
T21595 346-358 RB denotes specifically
T21594 343-345 TO denotes to
T21593 331-342 VB denotes established
T21592 324-330 NN denotes enzyme
T21591 319-323 JJ denotes only
T21590 315-318 DT denotes the
T21589 312-314 VB denotes is
T21588 307-311 NN denotes PP2A
T21587 305-306 -COMMA- denotes ,
T21586 296-305 NN denotes knowledge
T21585 292-295 PRP-DOLLAR- denotes our
T21584 289-291 TO denotes To
T21583 281-287 NN denotes Thr308
T21582 273-280 VB denotes targets
T21581 268-272 WDT denotes that
T21580 256-267 NN denotes phosphatase
T21579 254-255 DT denotes a
T21578 245-253 VB denotes inhibits
T21577 238-244 NN denotes kinase
T21576 233-237 NN denotes RIP1
T21575 228-232 IN denotes that
T21574 225-227 VB denotes is
T21573 213-224 NN denotes possibility
T21572 209-212 CD denotes One
T21571 192-207 NN denotes phosphorylation
T21570 185-191 NN denotes Thr308
T21569 181-184 NN denotes Akt
T21568 178-180 IN denotes in
T21567 169-177 NN denotes increase
T21566 154-168 JJ denotes RIP1-dependent
T21565 150-153 DT denotes the
T21564 147-149 IN denotes of
T21563 137-146 NN denotes mechanism
T21562 133-136 DT denotes the
T21561 130-132 VB denotes is
T21560 125-129 WP denotes what
T21559 123-124 -COMMA- denotes ,
T21558 118-123 RB denotes First
T21557 105-116 NN denotes necroptosis
T21556 98-104 IN denotes during
T21555 94-97 NN denotes Akt
T21554 91-93 IN denotes of
T21553 80-90 NN denotes regulation
T21552 71-79 JJ denotes specific
T21551 67-70 DT denotes the
T21550 64-66 TO denotes to
T21549 55-63 JJ denotes relevant
T21548 45-54 NN denotes questions
T21547 33-44 JJ denotes mechanistic
T21546 23-32 JJ denotes important
T21545 18-22 DT denotes some
T21544 12-17 VB denotes raise
T21543 4-11 NN denotes results
T21542 0-3 PRP-DOLLAR- denotes Our
T21686 894-896 TO denotes to
T21685 888-893 VB denotes leads
T21728 1161-1162 -COMMA- denotes ,
T21727 1154-1161 NN denotes peptide
T21726 1147-1153 NN denotes Thr435
T21725 1139-1146 IN denotes against
T21724 1132-1138 VB denotes raised
T21723 1123-1131 NN denotes antibody
T21722 1106-1122 JJ denotes phospho-specific
T21721 1104-1105 DT denotes a
T21720 1099-1103 IN denotes with
T21719 1090-1098 NN denotes blotting
T21718 1082-1089 JJ denotes western
T21717 1079-1081 CC denotes or
T21716 1066-1078 NN denotes spectrometry
T21715 1061-1065 NN denotes mass
T21714 1054-1060 CC denotes either
T21713 1048-1053 VB denotes using
T21712 1042-1047 NN denotes cells
T21711 1037-1041 NN denotes L929
T21710 1034-1036 IN denotes in
T21709 1030-1033 NN denotes Akt
T21708 1019-1029 JJ denotes endogenous
T21707 1016-1018 IN denotes on
T21706 1007-1015 NN denotes residues
T21705 1001-1006 DT denotes these
T21704 998-1000 IN denotes of
T21703 982-997 NN denotes phosphorylation
T21702 974-981 VB denotes confirm
T21701 971-973 TO denotes to
T21700 966-970 JJ denotes able
T21699 962-965 RB denotes not
T21698 957-961 VB denotes were
T21697 954-956 PRP denotes we
T21696 952-953 -COMMA- denotes ,
T21695 945-952 RB denotes However
T21694 932-943 NN denotes necroptosis
T21693 924-931 VB denotes promote
T21692 921-923 TO denotes to
T21691 913-920 NN denotes ability
T21690 909-912 PRP-DOLLAR- denotes its
T21689 906-908 IN denotes of
T21688 901-905 NN denotes loss
T21687 897-900 DT denotes the
T21684 880-887 NN denotes Myr-Akt
T21683 877-879 IN denotes in
T21682 873-876 NN denotes Ala
T21681 870-872 TO denotes to
R14190 T21543 T21542 arg1Of results,Our
R14191 T21543 T21544 arg1Of results,raise
R14192 T21548 T21544 arg2Of questions,raise
R14193 T21548 T21545 arg1Of questions,some
R14194 T21548 T21546 arg1Of questions,important
R14195 T21548 T21547 arg1Of questions,mechanistic
R14196 T21548 T21549 arg1Of questions,relevant
R14197 T21549 T21550 arg1Of relevant,to
R14198 T21553 T21550 arg2Of regulation,to
R14199 T21553 T21551 arg1Of regulation,the
R14200 T21553 T21552 arg1Of regulation,specific
R14201 T21553 T21554 arg1Of regulation,of
R14202 T21553 T21556 arg1Of regulation,during
R14203 T21555 T21554 arg2Of Akt,of
R14204 T21557 T21556 arg2Of necroptosis,during
R14205 T21560 T21561 arg1Of what,is
R14206 T21561 T21558 arg1Of is,First
R14207 T21561 T21559 arg1Of is,","
R14208 T21563 T21561 arg2Of mechanism,is
R14209 T21563 T21562 arg1Of mechanism,the
R14210 T21563 T21564 arg1Of mechanism,of
R14211 T21567 T21564 arg2Of increase,of
R14212 T21567 T21565 arg1Of increase,the
R14213 T21567 T21566 arg1Of increase,RIP1-dependent
R14214 T21567 T21568 arg1Of increase,in
R14215 T21571 T21568 arg2Of phosphorylation,in
R14216 T21571 T21569 arg1Of phosphorylation,Akt
R14217 T21571 T21570 arg1Of phosphorylation,Thr308
R14218 T21573 T21572 arg1Of possibility,One
R14219 T21573 T21574 arg1Of possibility,is
R14220 T21577 T21576 arg1Of kinase,RIP1
R14221 T21577 T21578 arg1Of kinase,inhibits
R14222 T21578 T21574 arg2Of inhibits,is
R14223 T21578 T21575 arg1Of inhibits,that
R14224 T21580 T21578 arg2Of phosphatase,inhibits
R14225 T21580 T21579 arg1Of phosphatase,a
R14226 T21580 T21581 arg1Of phosphatase,that
R14227 T21580 T21582 arg1Of phosphatase,targets
R14228 T21583 T21582 arg2Of Thr308,targets
R14229 T21586 T21584 arg2Of knowledge,To
R14230 T21586 T21585 arg1Of knowledge,our
R14231 T21588 T21589 arg1Of PP2A,is
R14232 T21589 T21584 arg1Of is,To
R14233 T21589 T21587 arg1Of is,","
R14234 T21592 T21589 arg2Of enzyme,is
R14235 T21592 T21590 arg1Of enzyme,the
R14236 T21592 T21591 arg1Of enzyme,only
R14237 T21592 T21593 arg2Of enzyme,established
R14238 T21593 T21594 modOf established,to
R14239 T21596 T21594 arg1Of dephosphorylate,to
R14240 T21596 T21595 arg1Of dephosphorylate,specifically
R14241 T21596 T21599 arg1Of dephosphorylate,[
R14242 T21598 T21596 arg2Of residue,dephosphorylate
R14243 T21598 T21597 arg1Of residue,this
R14244 T21600 T21599 arg2Of 45,[
R14245 T21601 T21599 arg3Of ],[
R14246 T21604 T21605 arg1Of we,did
R14247 T21604 T21607 arg1Of we,observe
R14248 T21607 T21602 arg1Of observe,However
R14249 T21607 T21603 arg1Of observe,","
R14250 T21607 T21605 arg2Of observe,did
R14251 T21607 T21606 arg1Of observe,not
R14252 T21609 T21607 arg2Of effect,observe
R14253 T21609 T21608 arg1Of effect,any
R14254 T21609 T21610 arg1Of effect,of
R14255 T21609 T21617 arg1Of effect,","
R14256 T21609 T21618 arg1Of effect,on
R14257 T21613 T21610 arg2Of inhibitor,of
R14258 T21613 T21611 arg1Of inhibitor,the
R14259 T21613 T21612 arg1Of inhibitor,PP2A
R14260 T21613 T21614 arg1Of inhibitor,","
R14261 T21616 T21614 arg2Of acid,","
R14262 T21616 T21615 arg1Of acid,okadaic
R14263 T21620 T21619 arg1Of phosphorylation,Thr308
R14264 T21620 T21621 arg1Of phosphorylation,or
R14265 T21621 T21618 arg2Of or,on
R14266 T21621 T21625 arg1Of or,in
R14267 T21622 T21621 arg2Of activation,or
R14268 T21622 T21623 arg1Of activation,of
R14269 T21624 T21623 arg2Of necroptosis,of
R14270 T21627 T21625 arg2Of cells,in
R14271 T21627 T21626 arg1Of cells,L929
R14272 T21629 T21628 arg1Of possibility,Another
R14273 T21629 T21630 arg1Of possibility,is
R14274 T21633 T21632 arg1Of increase,the
R14275 T21633 T21634 arg1Of increase,in
R14276 T21633 T21636 arg1Of increase,results
R14277 T21635 T21634 arg2Of Thr308,in
R14278 T21636 T21630 arg2Of results,is
R14279 T21636 T21631 arg1Of results,that
R14280 T21636 T21637 arg1Of results,from
R14281 T21639 T21637 arg2Of kinase,from
R14282 T21639 T21638 arg1Of kinase,RIP1
R14283 T21639 T21640 arg1Of kinase,targeting
R14284 T21641 T21642 arg1Of PDK1,","
R14285 T21642 T21644 arg1Of ",",or
R14286 T21643 T21642 arg2Of Akt,","
R14287 T21645 T21644 arg2Of scaffolding,or
R14288 T21646 T21640 arg2Of factors,targeting
R14289 T21646 T21641 arg1Of factors,PDK1
R14290 T21646 T21643 arg1Of factors,Akt
R14291 T21646 T21645 arg1Of factors,scaffolding
R14292 T21646 T21647 arg1Of factors,that
R14293 T21646 T21648 arg1Of factors,bring
R14294 T21651 T21648 arg2Of kinases,bring
R14295 T21651 T21649 arg1Of kinases,these
R14296 T21651 T21650 arg1Of kinases,two
R14297 T21651 T21652 arg1Of kinases,together
R14298 T21655 T21656 arg1Of we,observed
R14299 T21656 T21653 arg1Of observed,Interestingly
R14300 T21656 T21654 arg1Of observed,","
R14301 T21657 T21656 arg2Of phosphorylation,observed
R14302 T21657 T21658 arg1Of phosphorylation,of
R14303 T21657 T21660 arg1Of phosphorylation,by
R14304 T21659 T21658 arg2Of Akt,of
R14305 T21663 T21661 arg1Of kinase,recombinant
R14306 T21663 T21662 arg1Of kinase,RIP1
R14307 T21663 T21665 arg1Of kinase,vitro
R14308 T21663 T21666 arg1Of kinase,on
R14309 T21663 T21671 arg1Of kinase,and
R14310 T21665 T21664 arg1Of vitro,in
R14311 T21667 T21666 arg2Of Thr146,on
R14312 T21667 T21668 arg1Of Thr146,","
R14313 T21669 T21668 arg2Of 195/197,","
R14314 T21671 T21660 arg2Of and,by
R14315 T21671 T21670 arg1Of and,","
R14316 T21672 T21673 arg1Of 435,and
R14317 T21673 T21671 arg2Of and,and
R14318 T21675 T21673 arg2Of residues,and
R14319 T21675 T21674 arg1Of residues,Ser381
R14320 T21678 T21681 arg1Of mutating,to
R14321 T21678 T21685 arg1Of mutating,leads
R14322 T21680 T21678 arg2Of residues,mutating
R14323 T21680 T21679 arg1Of residues,these
R14324 T21682 T21681 arg2Of Ala,to
R14325 T21682 T21683 arg1Of Ala,in
R14326 T21684 T21683 arg2Of Myr-Akt,in
R14327 T21685 T21676 arg1Of leads,Furthermore
R14328 T21685 T21677 arg1Of leads,","
R14329 T21685 T21686 arg1Of leads,to
R14330 T21688 T21686 arg2Of loss,to
R14331 T21688 T21687 arg1Of loss,the
R14332 T21688 T21689 arg1Of loss,of
R14333 T21691 T21689 arg2Of ability,of
R14334 T21691 T21690 arg1Of ability,its
R14335 T21691 T21692 modOf ability,to
R14336 T21693 T21692 arg1Of promote,to
R14337 T21694 T21693 arg2Of necroptosis,promote
R14338 T21697 T21698 arg1Of we,were
R14339 T21697 T21700 arg1Of we,able
R14340 T21697 T21702 arg1Of we,confirm
R14341 T21698 T21695 arg1Of were,However
R14342 T21698 T21696 arg1Of were,","
R14343 T21698 T21699 arg1Of were,not
R14344 T21698 T21728 arg1Of were,","
R14345 T21698 T21729 modOf were,suggesting
R14346 T21700 T21698 arg2Of able,were
R14347 T21702 T21700 arg2Of confirm,able
R14348 T21702 T21701 arg1Of confirm,to
R14349 T21703 T21702 arg2Of phosphorylation,confirm
R14350 T21703 T21704 arg1Of phosphorylation,of
R14351 T21703 T21707 arg1Of phosphorylation,on
R14352 T21706 T21704 arg2Of residues,of
R14353 T21706 T21705 arg1Of residues,these
R14354 T21709 T21707 arg2Of Akt,on
R14355 T21709 T21708 arg1Of Akt,endogenous
R14356 T21709 T21710 arg1Of Akt,in
R14357 T21709 T21713 arg1Of Akt,using
R14358 T21712 T21710 arg2Of cells,in
R14359 T21712 T21711 arg1Of cells,L929
R14360 T21716 T21715 arg1Of spectrometry,mass
R14361 T21716 T21717 arg1Of spectrometry,or
R14362 T21717 T21713 arg2Of or,using
R14363 T21717 T21714 arg1Of or,either
R14364 T21717 T21720 arg1Of or,with
R14365 T21719 T21717 arg2Of blotting,or
R14366 T21719 T21718 arg1Of blotting,western
R14367 T21723 T21720 arg2Of antibody,with
R14368 T21723 T21721 arg1Of antibody,a
R14369 T21723 T21722 arg1Of antibody,phospho-specific
R14370 T21723 T21724 arg2Of antibody,raised
R14371 T21724 T21725 arg1Of raised,against
R14372 T21727 T21725 arg2Of peptide,against
R14373 T21727 T21726 arg1Of peptide,Thr435
R14374 T21732 T21731 arg1Of phosphorylation,direct
R14375 T21732 T21733 arg1Of phosphorylation,of
R14376 T21732 T21735 arg1Of phosphorylation,by
R14377 T21732 T21738 arg1Of phosphorylation,represents
R14378 T21732 T21744 arg1Of phosphorylation,does
R14379 T21732 T21746 arg1Of phosphorylation,reflect
R14380 T21734 T21733 arg2Of Akt,of
R14381 T21736 T21735 arg2Of RIP1,by
R14382 T21738 T21743 arg1Of represents,and
R14383 T21741 T21740 arg1Of vitro,in
R14384 T21742 T21738 arg2Of artifact,represents
R14385 T21742 T21739 arg1Of artifact,an
R14386 T21742 T21741 arg1Of artifact,vitro
R14387 T21743 T21729 arg2Of and,suggesting
R14388 T21743 T21730 arg1Of and,that
R14389 T21743 T21737 arg1Of and,likely
R14390 T21746 T21743 arg2Of reflect,and
R14391 T21746 T21744 arg2Of reflect,does
R14392 T21746 T21745 arg1Of reflect,not
R14393 T21748 T21746 arg2Of regulation,reflect
R14394 T21748 T21747 arg1Of regulation,endogenous
R14395 T21751 T21752 arg1Of what,are
R14396 T21752 T21749 arg1Of are,Second
R14397 T21752 T21750 arg1Of are,","
R14398 T21755 T21752 arg2Of substrates,are
R14399 T21755 T21753 arg1Of substrates,the
R14400 T21755 T21754 arg1Of substrates,key
R14401 T21755 T21756 arg1Of substrates,of
R14402 T21755 T21758 arg1Of substrates,that
R14403 T21755 T21759 arg1Of substrates,promote
R14404 T21757 T21756 arg2Of Akt,of
R14405 T21761 T21760 arg1Of death,necrotic
R14406 T21761 T21762 arg1Of death,and
R14407 T21762 T21759 arg2Of and,promote
R14408 T21764 T21762 arg2Of synthesis,and
R14409 T21764 T21763 arg1Of synthesis,TNFα
R14410 T21768 T21765 arg2Of hand,On
R14411 T21768 T21766 arg1Of hand,the
R14412 T21768 T21767 arg1Of hand,one
R14413 T21771 T21770 arg1Of data,our
R14414 T21771 T21772 arg1Of data,suggest
R14415 T21772 T21765 arg1Of suggest,On
R14416 T21772 T21769 arg1Of suggest,","
R14417 T21774 T21772 arg2Of roles,suggest
R14418 T21774 T21773 arg1Of roles,new
R14419 T21774 T21775 arg1Of roles,for
R14420 T21778 T21775 arg2Of pathways,for
R14421 T21778 T21776 arg1Of pathways,Akt
R14422 T21778 T21777 arg1Of pathways,effector
R14423 T21778 T21779 arg2Of pathways,mediated
R14424 T21779 T21782 arg1Of mediated,in
R14425 T21781 T21779 arg1Of mTORC1,mediated
R14426 T21781 T21780 arg2Of mTORC1,by
R14427 T21784 T21782 arg2Of control,in
R14428 T21784 T21783 arg1Of control,necroptotic
R14429 T21788 T21785 arg2Of hand,On
R14430 T21788 T21786 arg1Of hand,the
R14431 T21788 T21787 arg1Of hand,other
R14432 T21790 T21791 arg1Of we,have
R14433 T21790 T21792 arg1Of we,observed
R14434 T21792 T21785 arg1Of observed,On
R14435 T21792 T21789 arg1Of observed,","
R14436 T21792 T21791 arg2Of observed,have
R14437 T21792 T21799 arg1Of observed,under
R14438 T21792 T21802 arg1Of observed,","
R14439 T21792 T21803 modOf observed,suggesting
R14440 T21794 T21793 arg1Of modest,only
R14441 T21795 T21792 arg2Of changes,observed
R14442 T21795 T21794 arg1Of changes,modest
R14443 T21795 T21796 arg1Of changes,in
R14444 T21798 T21796 arg2Of activity,in
R14445 T21798 T21797 arg1Of activity,mTORC1
R14446 T21801 T21799 arg2Of conditions,under
R14447 T21801 T21800 arg1Of conditions,necroptotic
R14448 T21807 T21805 arg1Of substrates,additional
R14449 T21807 T21806 arg1Of substrates,Akt
R14450 T21807 T21808 arg1Of substrates,are
R14451 T21807 T21809 arg1Of substrates,likely
R14452 T21807 T21811 arg1Of substrates,be
R14453 T21807 T21812 arg2Of substrates,involved
R14454 T21808 T21803 arg2Of are,suggesting
R14455 T21808 T21804 arg1Of are,that
R14456 T21809 T21808 arg2Of likely,are
R14457 T21812 T21809 arg2Of involved,likely
R14458 T21812 T21810 arg1Of involved,to
R14459 T21812 T21811 arg2Of involved,be
R14460 T21813 T21814 arg1Of This,warrants
R14466 T21816 T21814 arg2Of re-evaluation,warrants
R14485 T21838 T21843 arg1Of mechanisms,remain
R14486 T21838 T21845 arg1Of mechanisms,be
R14487 T21838 T21846 arg2Of mechanisms,elucidated
R14493 T21846 T21843 arg2Of elucidated,remain
R14494 T21846 T21844 arg1Of elucidated,to
R14495 T21846 T21845 arg2Of elucidated,be
R14496 T21848 T21849 arg1Of there,are
R14497 T21849 T21847 arg2Of are,While
R14498 T21852 T21849 arg2Of examples,are
R14499 T21852 T21850 arg1Of examples,some
R14500 T21852 T21851 arg1Of examples,recent
R14501 T21852 T21853 arg1Of examples,of
R14502 T21855 T21853 arg2Of regulation,of
R14503 T21855 T21854 arg1Of regulation,mTORC1-dependent
R14504 T21855 T21856 arg1Of regulation,of
R14505 T21857 T21856 arg2Of JNK,of
R14506 T21860 T21859 arg1Of following,e.g.
R14507 T21862 T21860 arg2Of stress,following
R14508 T21862 T21861 arg1Of stress,ER
R14509 T21862 T21863 arg1Of stress,[
R14510 T21864 T21863 arg2Of 46,[
R14511 T21865 T21863 arg3Of ],[
R14512 T21869 T21867 arg1Of mechanisms,the
R14513 T21869 T21868 arg1Of mechanisms,exact
R14514 T21869 T21870 arg1Of mechanisms,during
R14515 T21869 T21872 arg1Of mechanisms,remain
R14516 T21869 T21874 arg1Of mechanisms,be
R14517 T21869 T21875 arg2Of mechanisms,established
R14518 T21871 T21870 arg2Of necroptosis,during
R14519 T21872 T21847 arg1Of remain,While
R14520 T21872 T21858 arg1Of remain,","
R14521 T21872 T21860 arg1Of remain,following
R14522 T21872 T21866 arg1Of remain,","
R14523 T21875 T21872 arg2Of established,remain
R14524 T21875 T21873 arg1Of established,to
R14525 T21875 T21874 arg2Of established,be
R14526 T21878 T21877 arg1Of activation,the
R14527 T21878 T21879 arg1Of activation,of
R14528 T21878 T21881 arg1Of activation,by
R14529 T21878 T21883 arg1Of activation,and
R14530 T21880 T21879 arg2Of JNK,of
R14531 T21882 T21881 arg2Of TNFα,by
R14532 T21883 T21876 arg2Of and,Given
R14533 T21885 T21883 arg2Of importance,and
R14534 T21885 T21884 arg1Of importance,the
R14535 T21885 T21886 arg1Of importance,of
R14536 T21889 T21886 arg2Of control,of
R14537 T21889 T21887 arg1Of control,mTORC1-dependent
R14538 T21889 T21888 arg1Of control,translational
R14539 T21889 T21890 arg1Of control,in
R14540 T21891 T21890 arg2Of necroptosis,in
R14541 T21894 T21893 arg1Of possibility,one
R14542 T21894 T21895 arg1Of possibility,is
R14543 T21895 T21876 arg1Of is,Given
R14544 T21895 T21892 arg1Of is,","
R14545 T21897 T21898 arg1Of mTORC1,contributes
R14546 T21897 T21905 arg1Of mTORC1,forms
R14547 T21898 T21899 arg1Of contributes,to
R14548 T21898 T21904 arg1Of contributes,and
R14549 T21901 T21899 arg2Of translation,to
R14550 T21901 T21900 arg1Of translation,the
R14551 T21901 T21902 arg1Of translation,of
R14552 T21903 T21902 arg2Of TNFα,of
R14553 T21904 T21895 arg2Of and,is
R14554 T21904 T21896 arg1Of and,that
R14555 T21905 T21904 arg2Of forms,and
R14556 T21910 T21905 arg2Of loop,forms
R14557 T21910 T21906 arg1Of loop,a
R14558 T21910 T21907 arg1Of loop,positive
R14559 T21910 T21908 arg1Of loop,feed
R14560 T21910 T21909 arg1Of loop,forward
R14561 T21910 T21911 arg1Of loop,with
R14562 T21912 T21911 arg2Of JNK,with
R14461 T21814 T21827 arg1Of warrants,","
R14462 T21814 T21828 arg1Of warrants,since
R14463 T21816 T21815 arg1Of re-evaluation,a
R14464 T21816 T21817 arg1Of re-evaluation,of
R14465 T21816 T21824 arg1Of re-evaluation,in
R14467 T21819 T21817 arg2Of roles,of
R14468 T21819 T21818 arg1Of roles,the
R14469 T21819 T21820 arg1Of roles,of
R14470 T21823 T21820 arg2Of substrates,of
R14471 T21823 T21821 arg1Of substrates,additional
R14472 T21823 T21822 arg1Of substrates,Akt
R14473 T21826 T21824 arg2Of death,in
R14474 T21826 T21825 arg1Of death,necroptotic
R14475 T21831 T21829 arg1Of connections,no
R14476 T21831 T21830 arg1Of connections,such
R14477 T21831 T21832 arg1Of connections,have
R14478 T21831 T21833 arg1Of connections,been
R14479 T21831 T21834 arg2Of connections,established
R14480 T21834 T21828 arg2Of established,since
R14481 T21834 T21832 arg2Of established,have
R14482 T21834 T21833 arg2Of established,been
R14483 T21838 T21837 arg1Of mechanisms,the
R14484 T21838 T21839 arg1Of mechanisms,connecting
R14488 T21840 T21839 arg2Of mTORC1,connecting
R14489 T21840 T21841 arg1Of mTORC1,to
R14490 T21842 T21841 arg2Of JNK,to
R14491 T21843 T21835 arg1Of remain,Similarly
R14492 T21843 T21836 arg1Of remain,","

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T21051 626-630 Antecedent denotes PDK1
T21050 670-687 Anaphor denotes these two kinases
R13989 T21050 T21051 boundBy these two kinases,PDK1

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T21068 2248-2252 Protein denotes TNFα
T21067 2101-2105 Protein denotes TNFα
T21066 1375-1379 Protein denotes TNFα
T21065 1212-1216 Protein denotes RIP1
T21064 880-887 Protein denotes Myr-Akt
T21063 763-767 Protein denotes RIP1
T21062 626-630 Protein denotes PDK1
T21061 604-608 Protein denotes RIP1
T21060 233-237 Protein denotes RIP1
T21059 154-158 Protein denotes RIP1

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T22948 1988-1990 http://www.uniprot.org/uniprot/P03372 denotes ER
T22939 2248-2252 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T22938 2101-2105 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T22937 1375-1379 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T22925 1212-1216 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T22924 763-767 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T22923 604-608 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T22922 233-237 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T22921 154-158 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T22869 1735-1738 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22868 1636-1639 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22867 1439-1442 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22866 1339-1342 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22865 1205-1208 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22864 1030-1033 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22863 884-887 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22862 744-747 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22861 632-635 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22860 181-184 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22859 94-97 http://www.uniprot.org/uniprot/P31751 denotes Akt
T22835 1735-1738 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22834 1636-1639 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22833 1439-1442 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22832 1339-1342 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22831 1205-1208 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22830 1030-1033 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22829 884-887 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22828 744-747 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22827 632-635 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22826 181-184 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22825 94-97 http://www.uniprot.org/uniprot/P31749 denotes Akt
T22903 1735-1738 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T22902 1636-1639 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T22901 1439-1442 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T22900 1339-1342 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T22899 1205-1208 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T22898 1030-1033 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T22897 884-887 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T22896 744-747 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T22895 632-635 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T22894 181-184 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T22893 94-97 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt

GO-BP

Id Subject Object Predicate Lexical cue
T21213 2233-2244 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T21212 626-630 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T21211 480-509 http://purl.obolibrary.org/obo/GO_0042327 denotes phosphorylation or activation
T21210 256-267 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T21208 238-253 http://purl.obolibrary.org/obo/GO_0033673 denotes kinase inhibits
T21203 1954-1964 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T21202 1288-1298 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T21201 80-90 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T21182 1765-1770 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T21181 1365-1370 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T21164 1380-1389 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T21161 2297-2300 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T21160 2094-2097 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T21159 1968-1971 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T21158 1868-1871 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T21143 2170-2181 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T21142 2032-2043 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T21141 932-943 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T21140 513-524 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T21139 105-116 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T21132 499-524 http://purl.obolibrary.org/obo/GO_0070266 denotes activation of necroptosis
T21119 2170-2181 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T21118 2032-2043 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T21117 932-943 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T21116 513-524 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T21115 105-116 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T21111 1186-1201 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T21110 982-997 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T21109 725-740 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T21108 480-495 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T21107 192-207 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation

GO-MF

Id Subject Object Predicate Lexical cue
T21275 1123-1131 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T21274 626-630 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T21273 256-267 http://purl.obolibrary.org/obo/GO_0016791 denotes phosphatase
T21272 2297-2300 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T21271 2094-2097 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T21270 1968-1971 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T21269 1868-1871 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-CC

Id Subject Object Predicate Lexical cue
T21281 1042-1047 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21280 533-538 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T21303 1988-1990 http://purl.obolibrary.org/obo/GO_0005783 denotes ER
T21302 1123-1131 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T21301 1123-1131 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T21299 2207-2213 http://purl.obolibrary.org/obo/GO_0031931 denotes mTORC1
T21298 2128-2134 http://purl.obolibrary.org/obo/GO_0031931 denotes mTORC1
T21297 1937-1943 http://purl.obolibrary.org/obo/GO_0031931 denotes mTORC1
T21296 1858-1864 http://purl.obolibrary.org/obo/GO_0031931 denotes mTORC1
T21295 1563-1569 http://purl.obolibrary.org/obo/GO_0031931 denotes mTORC1
T21294 1473-1479 http://purl.obolibrary.org/obo/GO_0031931 denotes mTORC1

sentences

Id Subject Object Predicate Lexical cue
T20956 2070-2301 Sentence denotes Given the activation of JNK by TNFα and the importance of mTORC1-dependent translational control in necroptosis, one possibility is that mTORC1 contributes to the translation of TNFα and forms a positive feed forward loop with JNK.
T20955 1897-2069 Sentence denotes While there are some recent examples of mTORC1-dependent regulation of JNK, e.g. following ER stress [46], the exact mechanisms during necroptosis remain to be established.
T20954 1821-1896 Sentence denotes Similarly, the mechanisms connecting mTORC1 to JNK remain to be elucidated.
T20953 1678-1820 Sentence denotes This warrants a re-evaluation of the roles of additional Akt substrates in necroptotic death, since no such connections have been established.
T20952 1504-1677 Sentence denotes On the other hand, we have observed only modest changes in mTORC1 activity under necroptotic conditions, suggesting that additional Akt substrates are likely to be involved.
T20951 1391-1503 Sentence denotes On the one hand, our data suggest new roles for Akt effector pathways mediated by mTORC1 in necroptotic control.
T20950 1300-1390 Sentence denotes Second, what are the key substrates of Akt that promote necrotic death and TNFα synthesis?
T20949 945-1299 Sentence denotes However, we were not able to confirm phosphorylation of these residues on endogenous Akt in L929 cells using either mass spectrometry or western blotting with a phospho-specific antibody raised against Thr435 peptide, suggesting that direct phosphorylation of Akt by RIP1 likely represents an in vitro artifact and does not reflect endogenous regulation.
T20948 833-944 Sentence denotes Furthermore, mutating these residues to Ala in Myr-Akt leads to the loss of its ability to promote necroptosis.
T20947 698-832 Sentence denotes Interestingly, we observed phosphorylation of Akt by recombinant RIP1 kinase in vitro on Thr146, 195/197, and 435 and Ser381 residues.
T20946 540-697 Sentence denotes Another possibility is that the increase in Thr308 results from RIP1 kinase targeting PDK1, Akt or scaffolding factors that bring these two kinases together.
T20945 394-539 Sentence denotes However, we did not observe any effect of the PP2A inhibitor, okadaic acid, on Thr308 phosphorylation or activation of necroptosis in L929 cells.
T20944 289-393 Sentence denotes To our knowledge, PP2A is the only enzyme established to specifically dephosphorylate this residue [45].
T20943 209-288 Sentence denotes One possibility is that RIP1 kinase inhibits a phosphatase that targets Thr308.
T20942 118-208 Sentence denotes First, what is the mechanism of the RIP1-dependent increase in Akt Thr308 phosphorylation?
T20941 0-117 Sentence denotes Our results raise some important mechanistic questions relevant to the specific regulation of Akt during necroptosis.
T266 0-117 Sentence denotes Our results raise some important mechanistic questions relevant to the specific regulation of Akt during necroptosis.
T267 118-208 Sentence denotes First, what is the mechanism of the RIP1-dependent increase in Akt Thr308 phosphorylation?
T268 209-288 Sentence denotes One possibility is that RIP1 kinase inhibits a phosphatase that targets Thr308.
T269 289-393 Sentence denotes To our knowledge, PP2A is the only enzyme established to specifically dephosphorylate this residue [45].
T270 394-539 Sentence denotes However, we did not observe any effect of the PP2A inhibitor, okadaic acid, on Thr308 phosphorylation or activation of necroptosis in L929 cells.
T271 540-697 Sentence denotes Another possibility is that the increase in Thr308 results from RIP1 kinase targeting PDK1, Akt or scaffolding factors that bring these two kinases together.
T272 698-832 Sentence denotes Interestingly, we observed phosphorylation of Akt by recombinant RIP1 kinase in vitro on Thr146, 195/197, and 435 and Ser381 residues.
T273 833-944 Sentence denotes Furthermore, mutating these residues to Ala in Myr-Akt leads to the loss of its ability to promote necroptosis.
T274 945-1299 Sentence denotes However, we were not able to confirm phosphorylation of these residues on endogenous Akt in L929 cells using either mass spectrometry or western blotting with a phospho-specific antibody raised against Thr435 peptide, suggesting that direct phosphorylation of Akt by RIP1 likely represents an in vitro artifact and does not reflect endogenous regulation.
T275 1300-1390 Sentence denotes Second, what are the key substrates of Akt that promote necrotic death and TNFα synthesis?
T276 1391-1503 Sentence denotes On the one hand, our data suggest new roles for Akt effector pathways mediated by mTORC1 in necroptotic control.
T277 1504-1677 Sentence denotes On the other hand, we have observed only modest changes in mTORC1 activity under necroptotic conditions, suggesting that additional Akt substrates are likely to be involved.
T278 1678-1820 Sentence denotes This warrants a re-evaluation of the roles of additional Akt substrates in necroptotic death, since no such connections have been established.
T279 1821-1896 Sentence denotes Similarly, the mechanisms connecting mTORC1 to JNK remain to be elucidated.
T280 1897-2069 Sentence denotes While there are some recent examples of mTORC1-dependent regulation of JNK, e.g. following ER stress [46], the exact mechanisms during necroptosis remain to be established.
T281 2070-2301 Sentence denotes Given the activation of JNK by TNFα and the importance of mTORC1-dependent translational control in necroptosis, one possibility is that mTORC1 contributes to the translation of TNFα and forms a positive feed forward loop with JNK.

simple1

Id Subject Object Predicate Lexical cue
T21320 2248-2252 Protein denotes TNFα
T21319 2101-2105 Protein denotes TNFα
T21318 1375-1379 Protein denotes TNFα
T21317 1212-1216 Protein denotes RIP1
T21316 880-887 Protein denotes Myr-Akt
T21315 763-767 Protein denotes RIP1
T21314 626-630 Protein denotes PDK1
T21313 604-608 Protein denotes RIP1
T21312 233-237 Protein denotes RIP1
T21311 154-158 Protein denotes RIP1

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T22801 1348-1355 Positive_regulation denotes promote
T22767 2248-2252 Protein denotes TNFα
T22766 2101-2105 Protein denotes TNFα
T22765 1375-1379 Protein denotes TNFα
T22764 1212-1216 Protein denotes RIP1
T22763 880-887 Protein denotes Myr-Akt
T22762 763-767 Protein denotes RIP1
T22761 626-630 Protein denotes PDK1
T22760 604-608 Protein denotes RIP1
T22759 233-237 Protein denotes RIP1
T22758 154-158 Protein denotes RIP1
T22800 1380-1389 Gene_expression denotes synthesis
T22799 1186-1201 Phosphorylation denotes phosphorylation
R15386 T22764 T22799 themeOf RIP1,phosphorylation
R15387 T22765 T22800 themeOf TNFα,synthesis
R15401 T22800 T22801 themeOf synthesis,promote

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T23098 2248-2252 Protein denotes TNFα
T23097 2101-2105 Protein denotes TNFα
T23096 1375-1379 Protein denotes TNFα
T23095 1212-1216 Protein denotes RIP1
T23094 880-887 Protein denotes Myr-Akt
T23093 763-767 Protein denotes RIP1
T23092 626-630 Protein denotes PDK1
T23091 604-608 Protein denotes RIP1
T23090 233-237 Protein denotes RIP1
T23089 154-158 Protein denotes RIP1
T23132 1380-1389 Gene_expression denotes synthesis
T23131 1348-1355 Positive_regulation denotes promote
T23130 1186-1201 Phosphorylation denotes phosphorylation
R15463 T23095 T23130 themeOf RIP1,phosphorylation
R15464 T23096 T23132 themeOf TNFα,synthesis
R15476 T23132 T23131 themeOf synthesis,promote

DLUT931

Id Subject Object Predicate Lexical cue
T23010 2214-2225 Positive_regulation denotes contributes
T23009 1348-1355 Positive_regulation denotes promote
T23008 1380-1389 Gene_expression denotes synthesis
T23007 1288-1298 Regulation denotes regulation
T23006 1186-1201 Phosphorylation denotes phosphorylation
T23005 846-854 Negative_regulation denotes mutating
T23004 725-740 Phosphorylation denotes phosphorylation
T23003 616-625 Binding denotes targeting
T23002 245-253 Negative_regulation denotes inhibits
T22962 626-630 Protein denotes PDK1
T22961 604-608 Protein denotes RIP1
T22960 233-237 Protein denotes RIP1
T22959 154-158 Protein denotes RIP1
T22968 2248-2252 Protein denotes TNFα
T22967 2101-2105 Protein denotes TNFα
T22966 1375-1379 Protein denotes TNFα
T22965 1212-1216 Protein denotes RIP1
T22964 880-887 Protein denotes Myr-Akt
T22963 763-767 Protein denotes RIP1
R15437 T23006 T23007 themeOf phosphorylation,regulation
R15438 T23008 T23009 themeOf synthesis,promote
R15412 T22960 T23002 themeOf RIP1,inhibits
R15413 T22961 T23003 themeOf RIP1,targeting
R15414 T22962 T23003 themeOf PDK1,targeting
R15415 T22963 T23004 themeOf RIP1,phosphorylation
R15416 T22964 T23005 themeOf Myr-Akt,mutating
R15417 T22965 T23006 themeOf RIP1,phosphorylation
R15418 T22966 T23008 themeOf TNFα,synthesis
R15419 T22968 T23010 themeOf TNFα,contributes

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T23594 632-635 Protein denotes Akt
T23590 604-658 Protein denotes RIP1 kinase targeting PDK1, Akt or scaffolding factors
T23587 315-392 Protein denotes the only enzyme established to specifically dephosphorylate this residue [45]
T23582 816-831 Entity denotes Ser381 residues
T23580 2297-2300 Protein denotes JNK
T23578 1147-1161 Entity denotes Thr435 peptide
T23577 228-287 Protein denotes that RIP1 kinase inhibits a phosphatase that targets Thr308
T23576 741-747 Protein denotes of Akt
T23573 154-168 Protein denotes RIP1-dependent
T23572 1439-1460 Entity denotes Akt effector pathways
T23571 1474-1502 Entity denotes TORC1 in necroptotic control
T23566 1439-1442 Protein denotes Akt
T23565 1563-1569 Entity denotes mTORC1
T23564 94-97 Protein denotes Akt
T23561 1721-1749 Entity denotes of additional Akt substrates
T23555 238-244 Protein denotes kinase
T23547 433-443 Entity denotes of the PP2
T23546 1212-1216 Protein denotes RIP1
T23544 181-191 Entity denotes Akt Thr308
T23543 748-774 Protein denotes by recombinant RIP1 kinase
T23542 1965-1971 Protein denotes of JNK
T23537 581-590 Entity denotes in Thr308
T23533 1858-1864 Entity denotes mTORC1
T23531 1988-2002 Protein denotes ER stress [46]
T23529 456-468 Entity denotes okadaic acid
T23526 228-287 Protein denotes that RIP1 kinase inhibits a phosphatase that targets Thr308
T23520 626-630 Protein denotes PDK1
T23519 1865-1871 Protein denotes to JNK
T23518 2091-2097 Protein denotes of JNK
T23514 604-608 Protein denotes RIP1
T23513 281-287 Entity denotes Thr308
T23508 670-687 Protein denotes these two kinases
T23507 1339-1342 Protein denotes Akt
T23506 181-184 Protein denotes Akt
T23505 1375-1389 Protein denotes TNFα synthesis
T23504 1625-1650 Entity denotes additional Akt substrates
T23502 1636-1639 Protein denotes Akt
T23501 375-392 Entity denotes this residue [45]
T23500 1123-1131 Protein denotes antibody
T23497 855-887 Entity denotes these residues to Ala in Myr-Akt
T23496 998-1015 Entity denotes of these residues
T23495 763-767 Protein denotes RIP1
T23493 880-887 Protein denotes Myr-Akt
T23492 2101-2105 Protein denotes TNFα
T23491 473-479 Entity denotes Thr308
T23490 816-822 Entity denotes Ser381
T23485 1735-1738 Protein denotes Akt
T23482 1019-1033 Protein denotes endogenous Akt
T23481 1317-1389 Entity denotes the key substrates of Akt that promote necrotic death and TNFα synthesis
T23474 787-803 Entity denotes Thr146, 195/197,
T23473 445-469 Entity denotes inhibitor, okadaic acid,
T23652 1934-1971 Regulation denotes of mTORC1-dependent regulation of JNK
T23650 315-392 Gene_expression denotes the only enzyme established to specifically dephosphorylate this residue [45]
T23647 1847-1871 Binding denotes connecting mTORC1 to JNK
T23645 178-207 Phosphorylation denotes in Akt Thr308 phosphorylation
T23644 2076-2097 Positive_regulation denotes the activation of JNK
T23641 698-811 Phosphorylation denotes Interestingly, we observed phosphorylation of Akt by recombinant RIP1 kinase in vitro on Thr146, 195/197, and 435
T23635 2229-2252 Translation denotes the translation of TNFα
T23633 150-207 Regulation denotes the RIP1-dependent increase in Akt Thr308 phosphorylation
T23628 228-287 Negative_regulation denotes that RIP1 kinase inhibits a phosphatase that targets Thr308
T23626 150-207 Positive_regulation denotes the RIP1-dependent increase in Akt Thr308 phosphorylation
T23621 1202-1208 Protein denotes of Akt
T23619 1147-1153 Entity denotes Thr435
T23615 2207-2213 Entity denotes mTORC1
T23609 2245-2252 Protein denotes of TNFα
T23605 873-887 Entity denotes Ala in Myr-Akt
R15649 T23506 T23645 themeOf Akt,in Akt Thr308 phosphorylation
R15651 T23518 T23644 themeOf of JNK,the activation of JNK
R15652 T23519 T23647 themeOf to JNK,connecting mTORC1 to JNK
R15657 T23533 T23647 themeOf mTORC1,connecting mTORC1 to JNK
R15660 T23542 T23652 themeOf of JNK,of mTORC1-dependent regulation of JNK
R15661 T23543 T23641 causeOf by recombinant RIP1 kinase,"Interestingly, we observed phosphorylation of Akt by recombinant RIP1 kinase in vitro on Thr146, 195/197, and 435"
R15662 T23544 T23506 partOf Akt Thr308,Akt
R15663 T23544 T23645 siteOf Akt Thr308,in Akt Thr308 phosphorylation
R15667 T23555 T23628 causeOf kinase,that RIP1 kinase inhibits a phosphatase that targets Thr308
R15669 T23573 T23633 causeOf RIP1-dependent,the RIP1-dependent increase in Akt Thr308 phosphorylation
R15670 T23576 T23641 themeOf of Akt,"Interestingly, we observed phosphorylation of Akt by recombinant RIP1 kinase in vitro on Thr146, 195/197, and 435"
R15671 T23577 T23628 themeOf that RIP1 kinase inhibits a phosphatase that targets Thr308,that RIP1 kinase inhibits a phosphatase that targets Thr308
R15672 T23587 T23650 themeOf the only enzyme established to specifically dephosphorylate this residue [45],the only enzyme established to specifically dephosphorylate this residue [45]
R15678 T23609 T23635 themeOf of TNFα,the translation of TNFα
R15679 T23626 T23633 themeOf the RIP1-dependent increase in Akt Thr308 phosphorylation,the RIP1-dependent increase in Akt Thr308 phosphorylation
R15682 T23645 T23626 themeOf in Akt Thr308 phosphorylation,the RIP1-dependent increase in Akt Thr308 phosphorylation

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T24040 1054-1060 CC denotes either
T24039 1048-1053 VBG denotes using
T24038 1042-1047 NNS denotes cells
T24037 1037-1041 NNP denotes L929
T24036 1034-1036 IN denotes in
T24035 1030-1033 NNP denotes Akt
T24034 1019-1029 JJ denotes endogenous
T24033 1016-1018 IN denotes on
T24032 1007-1015 NNS denotes residues
T24031 1001-1006 DT denotes these
T24030 998-1000 IN denotes of
T24029 982-997 NN denotes phosphorylation
T24028 974-981 VB denotes confirm
T24027 971-973 TO denotes to
T24026 966-970 JJ denotes able
T24025 962-965 RB denotes not
T24024 957-961 VBD denotes were
T24023 954-956 PRP denotes we
T24022 952-953 , denotes ,
T24021 945-952 RB denotes However
T24020 943-944 . denotes .
T24019 932-943 NN denotes necroptosis
T24018 924-931 VB denotes promote
T24017 921-923 TO denotes to
T24016 913-920 NN denotes ability
T24015 909-912 PRP$ denotes its
T24014 906-908 IN denotes of
T24013 901-905 NN denotes loss
T24012 897-900 DT denotes the
T24011 894-896 TO denotes to
T24010 888-893 VBZ denotes leads
T24009 880-887 NNP denotes Myr-Akt
T24008 877-879 IN denotes in
T24007 873-876 NNP denotes Ala
T24006 870-872 TO denotes to
T24005 861-869 NNS denotes residues
T24004 855-860 DT denotes these
T24003 846-854 VBG denotes mutating
T24002 844-845 , denotes ,
T24001 833-844 RB denotes Furthermore
T24000 831-832 . denotes .
T23999 823-831 NNS denotes residues
T23998 816-822 CD denotes Ser381
T23997 812-815 CC denotes and
T23996 808-811 CD denotes 435
T23995 804-807 CC denotes and
T23994 802-803 , denotes ,
T23993 795-802 CD denotes 195/197
T23992 793-794 , denotes ,
T23991 787-793 NNP denotes Thr146
T23990 784-786 IN denotes on
T23989 778-783 NN denotes vitro
T23988 775-777 IN denotes in
T23987 768-774 NN denotes kinase
T23986 763-767 NNP denotes RIP1
T23985 751-762 JJ denotes recombinant
T23984 748-750 IN denotes by
T23983 744-747 NNP denotes Akt
T23982 741-743 IN denotes of
T23981 725-740 NN denotes phosphorylation
T23980 716-724 VBD denotes observed
T23979 713-715 PRP denotes we
T23978 711-712 , denotes ,
T23977 698-711 RB denotes Interestingly
T23976 696-697 . denotes .
T23975 688-696 RB denotes together
T23974 680-687 NNS denotes kinases
T23973 676-679 CD denotes two
T23972 670-675 DT denotes these
T23971 664-669 VBP denotes bring
T23970 659-663 WDT denotes that
T23969 651-658 NNS denotes factors
T23968 639-650 VBG denotes scaffolding
T23967 636-638 CC denotes or
T23966 632-635 NNP denotes Akt
T23965 630-631 , denotes ,
T23964 626-630 NNP denotes PDK1
T23963 616-625 VBG denotes targeting
T23962 609-615 NN denotes kinase
T23961 604-608 CD denotes RIP1
T23960 599-603 IN denotes from
T23959 591-598 NNS denotes results
T23958 584-590 CD denotes Thr308
T23957 581-583 IN denotes in
T23956 572-580 NN denotes increase
T23955 568-571 DT denotes the
T23954 563-567 IN denotes that
T23953 560-562 VBZ denotes is
T23952 548-559 NN denotes possibility
T23951 540-547 DT denotes Another
T23950 538-539 . denotes .
T23949 533-538 NNS denotes cells
T23948 528-532 CD denotes L929
T23947 525-527 IN denotes in
T23946 513-524 NN denotes necroptosis
T23945 510-512 IN denotes of
T23944 499-509 NN denotes activation
T23943 496-498 CC denotes or
T23942 480-495 NN denotes phosphorylation
T23941 473-479 CD denotes Thr308
T23940 470-472 IN denotes on
T23939 468-469 , denotes ,
T23938 464-468 NN denotes acid
T23937 456-463 JJ denotes okadaic
T23936 454-455 , denotes ,
T23935 445-454 NN denotes inhibitor
T23934 440-444 NNP denotes PP2A
T23933 436-439 DT denotes the
T23932 433-435 IN denotes of
T23931 426-432 NN denotes effect
T23930 422-425 DT denotes any
T23929 414-421 VB denotes observe
T23928 410-413 RB denotes not
T23927 406-409 VBD denotes did
T23926 403-405 PRP denotes we
T23925 401-402 , denotes ,
T23924 394-401 RB denotes However
T23923 392-393 . denotes .
T23922 391-392 NNP denotes ]
T23921 389-391 CD denotes 45
T23920 388-389 NNP denotes [
T23919 380-387 NN denotes residue
T23918 375-379 DT denotes this
T23917 359-374 VB denotes dephosphorylate
T23916 346-358 RB denotes specifically
T23915 343-345 TO denotes to
T23914 331-342 VBN denotes established
T23913 324-330 NN denotes enzyme
T23912 319-323 JJ denotes only
T23911 315-318 DT denotes the
T23910 312-314 VBZ denotes is
T23909 307-311 NNP denotes PP2A
T23908 305-306 , denotes ,
T23907 296-305 NN denotes knowledge
T23906 292-295 PRP$ denotes our
T23905 289-291 TO denotes To
T23904 287-288 . denotes .
T23903 281-287 NNP denotes Thr308
T23902 273-280 VBZ denotes targets
T23901 268-272 WDT denotes that
T23900 256-267 NN denotes phosphatase
T23899 254-255 DT denotes a
T23898 245-253 VBZ denotes inhibits
T23897 238-244 NN denotes kinase
T23896 233-237 CD denotes RIP1
T23895 228-232 IN denotes that
T23894 225-227 VBZ denotes is
T23893 213-224 NN denotes possibility
T23892 209-212 CD denotes One
T23891 207-208 . denotes ?
T23890 192-207 NN denotes phosphorylation
T23889 185-191 NNP denotes Thr308
T23888 181-184 NNP denotes Akt
T23887 178-180 IN denotes in
T23886 169-177 NN denotes increase
T23885 154-168 JJ denotes RIP1-dependent
T23884 150-153 DT denotes the
T23883 147-149 IN denotes of
T23882 137-146 NN denotes mechanism
T23881 133-136 DT denotes the
T23880 130-132 VBZ denotes is
T23879 125-129 WP denotes what
T23878 123-124 , denotes ,
T23877 118-123 RB denotes First
T23876 116-117 . denotes .
T23875 105-116 NN denotes necroptosis
T23874 98-104 IN denotes during
T23873 94-97 NNP denotes Akt
T23872 91-93 IN denotes of
T23871 80-90 NN denotes regulation
T23870 71-79 JJ denotes specific
T23869 67-70 DT denotes the
T23868 64-66 TO denotes to
T23867 55-63 JJ denotes relevant
T23866 45-54 NNS denotes questions
T23865 33-44 JJ denotes mechanistic
T23864 23-32 JJ denotes important
T23863 18-22 DT denotes some
T23862 12-17 VB denotes raise
T23861 4-11 NNS denotes results
T23860 0-3 PRP$ denotes Our
T24230 2207-2213 JJ denotes mTORC1
T24229 2202-2206 IN denotes that
T24228 2199-2201 VBZ denotes is
T24227 2187-2198 NN denotes possibility
T24226 2183-2186 CD denotes one
T24225 2181-2182 , denotes ,
T24224 2170-2181 NN denotes necroptosis
T24223 2167-2169 IN denotes in
T24222 2159-2166 NN denotes control
T24221 2145-2158 JJ denotes translational
T24220 2128-2144 JJ denotes mTORC1-dependent
T24219 2125-2127 IN denotes of
T24218 2114-2124 NN denotes importance
T24217 2110-2113 DT denotes the
T24216 2106-2109 CC denotes and
T24215 2101-2105 NNP denotes TNFα
T24214 2098-2100 IN denotes by
T24213 2094-2097 NNP denotes JNK
T24212 2091-2093 IN denotes of
T24211 2080-2090 NN denotes activation
T24210 2076-2079 DT denotes the
T24209 2070-2075 VBN denotes Given
T24208 2068-2069 . denotes .
T24207 2057-2068 VBN denotes established
T24206 2054-2056 VB denotes be
T24205 2051-2053 TO denotes to
T24204 2044-2050 VBP denotes remain
T24203 2032-2043 NN denotes necroptosis
T24202 2025-2031 IN denotes during
T24201 2014-2024 NNS denotes mechanisms
T24200 2008-2013 JJ denotes exact
T24199 2004-2007 DT denotes the
T24198 2002-2003 , denotes ,
T24197 2001-2002 NNP denotes ]
T24196 1999-2001 CD denotes 46
T24195 1998-1999 NNP denotes [
T24194 1991-1997 NN denotes stress
T24193 1988-1990 NNP denotes ER
T24192 1978-1987 VBG denotes following
T24191 1973-1977 FW denotes e.g.
T24190 1971-1972 , denotes ,
T24189 1968-1971 NNP denotes JNK
T24188 1965-1967 IN denotes of
T24187 1954-1964 NN denotes regulation
T24186 1937-1953 JJ denotes mTORC1-dependent
T24185 1934-1936 IN denotes of
T24184 1925-1933 NNS denotes examples
T24183 1918-1924 JJ denotes recent
T24182 1913-1917 DT denotes some
T24181 1909-1912 VBP denotes are
T24180 1903-1908 EX denotes there
T24179 1897-1902 IN denotes While
T24178 1895-1896 . denotes .
T24177 1885-1895 VBN denotes elucidated
T24176 1882-1884 VB denotes be
T24175 1879-1881 TO denotes to
T24174 1872-1878 VBP denotes remain
T24173 1868-1871 NNP denotes JNK
T24172 1865-1867 TO denotes to
T24171 1858-1864 NNP denotes mTORC1
T24170 1847-1857 VBG denotes connecting
T24169 1836-1846 NNS denotes mechanisms
T24168 1832-1835 DT denotes the
T24167 1830-1831 , denotes ,
T24166 1821-1830 RB denotes Similarly
T24165 1819-1820 . denotes .
T24164 1808-1819 VBN denotes established
T24163 1803-1807 VBN denotes been
T24162 1798-1802 VBP denotes have
T24161 1786-1797 NNS denotes connections
T24160 1781-1785 JJ denotes such
T24159 1778-1780 DT denotes no
T24158 1772-1777 IN denotes since
T24157 1770-1771 , denotes ,
T24156 1765-1770 NN denotes death
T24155 1753-1764 JJ denotes necroptotic
T24154 1750-1752 IN denotes in
T24153 1739-1749 NNS denotes substrates
T24152 1735-1738 NNP denotes Akt
T24151 1724-1734 JJ denotes additional
T24150 1721-1723 IN denotes of
T24149 1715-1720 NNS denotes roles
T24148 1711-1714 DT denotes the
T24147 1708-1710 IN denotes of
T24146 1694-1707 NN denotes re-evaluation
T24145 1692-1693 DT denotes a
T24144 1683-1691 VBZ denotes warrants
T24143 1678-1682 DT denotes This
T24142 1676-1677 . denotes .
T24141 1668-1676 VBN denotes involved
T24140 1665-1667 VB denotes be
T24139 1662-1664 TO denotes to
T24138 1655-1661 JJ denotes likely
T24137 1651-1654 VBP denotes are
T24136 1640-1650 NNS denotes substrates
T24135 1636-1639 NNP denotes Akt
T24134 1625-1635 JJ denotes additional
T24133 1620-1624 IN denotes that
T24132 1609-1619 VBG denotes suggesting
T24131 1607-1608 , denotes ,
T24130 1597-1607 NNS denotes conditions
T24129 1585-1596 JJ denotes necroptotic
T24128 1579-1584 IN denotes under
T24127 1570-1578 NN denotes activity
T24126 1563-1569 JJ denotes mTORC1
T24125 1560-1562 IN denotes in
T24124 1552-1559 NNS denotes changes
T24123 1545-1551 JJ denotes modest
T24122 1540-1544 RB denotes only
T24121 1531-1539 VBN denotes observed
T24120 1526-1530 VBP denotes have
T24119 1523-1525 PRP denotes we
T24118 1521-1522 , denotes ,
T24117 1517-1521 NN denotes hand
T24116 1511-1516 JJ denotes other
T24115 1507-1510 DT denotes the
T24114 1504-1506 IN denotes On
T24113 1502-1503 . denotes .
T24112 1495-1502 NN denotes control
T24111 1483-1494 JJ denotes necroptotic
T24110 1480-1482 IN denotes in
T24109 1473-1479 NNP denotes mTORC1
T24108 1470-1472 IN denotes by
T24107 1461-1469 VBN denotes mediated
T24106 1452-1460 NNS denotes pathways
T24105 1443-1451 NN denotes effector
T24104 1439-1442 NNP denotes Akt
T24103 1435-1438 IN denotes for
T24102 1429-1434 NNS denotes roles
T24101 1425-1428 JJ denotes new
T24100 1417-1424 VBP denotes suggest
T24099 1412-1416 NNS denotes data
T24098 1408-1411 PRP$ denotes our
T24097 1406-1407 , denotes ,
T24096 1402-1406 NN denotes hand
T24095 1398-1401 CD denotes one
T24094 1394-1397 DT denotes the
T24093 1391-1393 IN denotes On
T24092 1389-1390 . denotes ?
T24091 1380-1389 NN denotes synthesis
T24090 1375-1379 NNP denotes TNFα
T24089 1371-1374 CC denotes and
T24088 1365-1370 NN denotes death
T24087 1356-1364 JJ denotes necrotic
T24086 1348-1355 VBP denotes promote
T24085 1343-1347 WDT denotes that
T24084 1339-1342 NNP denotes Akt
T24083 1336-1338 IN denotes of
T24082 1325-1335 NNS denotes substrates
T24081 1321-1324 JJ denotes key
T24080 1317-1320 DT denotes the
T24079 1313-1316 VBP denotes are
T24078 1308-1312 WDT denotes what
T24077 1306-1307 , denotes ,
T24076 1300-1306 NNP denotes Second
T24075 1298-1299 . denotes .
T24074 1288-1298 NN denotes regulation
T24073 1277-1287 JJ denotes endogenous
T24072 1269-1276 VB denotes reflect
T24071 1265-1268 RB denotes not
T24070 1260-1264 VBZ denotes does
T24069 1256-1259 CC denotes and
T24068 1247-1255 NN denotes artifact
T24067 1241-1246 NN denotes vitro
T24066 1238-1240 IN denotes in
T24065 1235-1237 DT denotes an
T24064 1224-1234 VBZ denotes represents
T24063 1217-1223 JJ denotes likely
T24062 1212-1216 NNP denotes RIP1
T24061 1209-1211 IN denotes by
T24060 1205-1208 NNP denotes Akt
T24059 1202-1204 IN denotes of
T24058 1186-1201 NN denotes phosphorylation
T24057 1179-1185 JJ denotes direct
T24056 1174-1178 IN denotes that
T24055 1163-1173 VBG denotes suggesting
T24054 1161-1162 , denotes ,
T24053 1154-1161 NN denotes peptide
T24052 1147-1153 NNP denotes Thr435
T24051 1139-1146 IN denotes against
T24050 1132-1138 VBN denotes raised
T24049 1123-1131 NN denotes antibody
T24048 1106-1122 JJ denotes phospho-specific
T24047 1104-1105 DT denotes a
T24046 1099-1103 IN denotes with
T24045 1090-1098 VBG denotes blotting
T24044 1082-1089 JJ denotes western
T24043 1079-1081 CC denotes or
T24042 1066-1078 NN denotes spectrometry
T24041 1061-1065 NN denotes mass
T24246 2300-2301 . denotes .
T24245 2297-2300 NNP denotes JNK
T24244 2292-2296 IN denotes with
T24243 2287-2291 NN denotes loop
T24242 2279-2286 RB denotes forward
T24241 2274-2278 NN denotes feed
T24240 2265-2273 JJ denotes positive
T24239 2263-2264 DT denotes a
T24238 2257-2262 NNS denotes forms
T24237 2253-2256 CC denotes and
T24236 2248-2252 NNP denotes TNFα
T24235 2245-2247 IN denotes of
T24234 2233-2244 NN denotes translation
T24233 2229-2232 DT denotes the
T24232 2226-2228 TO denotes to
T24231 2214-2225 VBZ denotes contributes
R15889 T23860 T23861 poss Our,results
R15890 T23861 T23862 nsubj results,raise
R15891 T23862 T23862 ROOT raise,raise
R15892 T23863 T23866 det some,questions
R15893 T23864 T23866 amod important,questions
R15894 T23865 T23866 amod mechanistic,questions
R15895 T23866 T23862 dobj questions,raise
R15896 T23867 T23866 amod relevant,questions
R15897 T23868 T23867 prep to,relevant
R15898 T23869 T23871 det the,regulation
R15899 T23870 T23871 amod specific,regulation
R15900 T23871 T23868 pobj regulation,to
R15901 T23872 T23871 prep of,regulation
R15902 T23873 T23872 pobj Akt,of
R15903 T23874 T23871 prep during,regulation
R15904 T23875 T23874 pobj necroptosis,during
R15905 T23876 T23862 punct .,raise
R15906 T23877 T23880 advmod First,is
R15907 T23878 T23880 punct ",",is
R15908 T23879 T23880 attr what,is
R15909 T23880 T23880 ROOT is,is
R15910 T23881 T23882 det the,mechanism
R15911 T23882 T23880 attr mechanism,is
R15912 T23883 T23882 prep of,mechanism
R15913 T23884 T23886 det the,increase
R15914 T23885 T23886 amod RIP1-dependent,increase
R15915 T23886 T23883 pobj increase,of
R15916 T23887 T23886 prep in,increase
R15917 T23888 T23890 compound Akt,phosphorylation
R15918 T23889 T23890 compound Thr308,phosphorylation
R15919 T23890 T23887 pobj phosphorylation,in
R15920 T23891 T23880 punct ?,is
R15921 T23892 T23893 nummod One,possibility
R15922 T23893 T23894 nsubj possibility,is
R15923 T23894 T23894 ROOT is,is
R15924 T23895 T23898 mark that,inhibits
R15925 T23896 T23897 nummod RIP1,kinase
R15926 T23897 T23898 nsubj kinase,inhibits
R15927 T23898 T23894 ccomp inhibits,is
R15928 T23899 T23900 det a,phosphatase
R15929 T23900 T23898 dobj phosphatase,inhibits
R15930 T23901 T23902 nsubj that,targets
R15931 T23902 T23900 relcl targets,phosphatase
R15932 T23903 T23902 dobj Thr308,targets
R15933 T23904 T23894 punct .,is
R15934 T23905 T23910 prep To,is
R15935 T23906 T23907 poss our,knowledge
R15936 T23907 T23905 pobj knowledge,To
R15937 T23908 T23910 punct ",",is
R15938 T23909 T23910 nsubj PP2A,is
R15939 T23910 T23910 ROOT is,is
R15940 T23911 T23913 det the,enzyme
R15941 T23912 T23913 amod only,enzyme
R15942 T23913 T23910 attr enzyme,is
R15943 T23914 T23913 acl established,enzyme
R15944 T23915 T23917 aux to,dephosphorylate
R15945 T23916 T23917 advmod specifically,dephosphorylate
R15946 T23917 T23914 advcl dephosphorylate,established
R15947 T23918 T23919 det this,residue
R15948 T23919 T23917 dobj residue,dephosphorylate
R15949 T23920 T23922 nmod [,]
R15950 T23921 T23922 nummod 45,]
R15951 T23922 T23919 appos ],residue
R15952 T23923 T23910 punct .,is
R15953 T23924 T23929 advmod However,observe
R15954 T23925 T23929 punct ",",observe
R15955 T23926 T23929 nsubj we,observe
R15956 T23927 T23929 aux did,observe
R15957 T23928 T23929 neg not,observe
R15958 T23929 T23929 ROOT observe,observe
R15959 T23930 T23931 det any,effect
R15960 T23931 T23929 dobj effect,observe
R15961 T23932 T23931 prep of,effect
R15962 T23933 T23935 det the,inhibitor
R15963 T23934 T23935 compound PP2A,inhibitor
R15964 T23935 T23932 pobj inhibitor,of
R15965 T23936 T23931 punct ",",effect
R15966 T23937 T23938 amod okadaic,acid
R15967 T23938 T23929 dobj acid,observe
R15968 T23939 T23929 punct ",",observe
R15969 T23940 T23929 prep on,observe
R15970 T23941 T23942 nummod Thr308,phosphorylation
R15971 T23942 T23940 pobj phosphorylation,on
R15972 T23943 T23942 cc or,phosphorylation
R15973 T23944 T23942 conj activation,phosphorylation
R15974 T23945 T23944 prep of,activation
R15975 T23946 T23945 pobj necroptosis,of
R15976 T23947 T23942 prep in,phosphorylation
R15977 T23948 T23949 nummod L929,cells
R15978 T23949 T23947 pobj cells,in
R15979 T23950 T23929 punct .,observe
R15980 T23951 T23952 det Another,possibility
R15981 T23952 T23953 nsubj possibility,is
R15982 T23953 T23953 ROOT is,is
R15983 T23954 T23953 attr that,is
R15984 T23955 T23956 det the,increase
R15985 T23956 T23954 nsubj increase,that
R15986 T23957 T23956 prep in,increase
R15987 T23958 T23959 nummod Thr308,results
R15988 T23959 T23957 pobj results,in
R15989 T23960 T23956 prep from,increase
R15990 T23961 T23962 nummod RIP1,kinase
R15991 T23962 T23960 pobj kinase,from
R15992 T23963 T23956 acl targeting,increase
R15993 T23964 T23963 dobj PDK1,targeting
R15994 T23965 T23964 punct ",",PDK1
R15995 T23966 T23964 conj Akt,PDK1
R15996 T23967 T23963 cc or,targeting
R15997 T23968 T23963 conj scaffolding,targeting
R15998 T23969 T23968 dobj factors,scaffolding
R15999 T23970 T23971 nsubj that,bring
R16000 T23971 T23969 relcl bring,factors
R16001 T23972 T23974 det these,kinases
R16002 T23973 T23974 nummod two,kinases
R16003 T23974 T23971 dobj kinases,bring
R16004 T23975 T23971 advmod together,bring
R16005 T23976 T23953 punct .,is
R16006 T23977 T23980 advmod Interestingly,observed
R16007 T23978 T23980 punct ",",observed
R16008 T23979 T23980 nsubj we,observed
R16009 T23980 T23980 ROOT observed,observed
R16010 T23981 T23980 dobj phosphorylation,observed
R16011 T23982 T23981 prep of,phosphorylation
R16012 T23983 T23982 pobj Akt,of
R16013 T23984 T23981 prep by,phosphorylation
R16014 T23985 T23987 amod recombinant,kinase
R16015 T23986 T23987 compound RIP1,kinase
R16016 T23987 T23984 pobj kinase,by
R16017 T23988 T23980 prep in,observed
R16018 T23989 T23988 pobj vitro,in
R16019 T23990 T23980 prep on,observed
R16020 T23991 T23990 pobj Thr146,on
R16021 T23992 T23991 punct ",",Thr146
R16022 T23993 T23991 appos 195/197,Thr146
R16023 T23994 T23991 punct ",",Thr146
R16024 T23995 T23991 cc and,Thr146
R16025 T23996 T23999 nummod 435,residues
R16026 T23997 T23996 cc and,435
R16027 T23998 T23996 conj Ser381,435
R16028 T23999 T23991 conj residues,Thr146
R16029 T24000 T23980 punct .,observed
R16030 T24001 T24010 advmod Furthermore,leads
R16031 T24002 T24010 punct ",",leads
R16032 T24003 T24010 csubj mutating,leads
R16033 T24004 T24005 det these,residues
R16034 T24005 T24003 dobj residues,mutating
R16035 T24006 T24003 prep to,mutating
R16036 T24007 T24006 pobj Ala,to
R16037 T24008 T24007 prep in,Ala
R16038 T24009 T24008 pobj Myr-Akt,in
R16039 T24010 T24010 ROOT leads,leads
R16040 T24011 T24010 prep to,leads
R16041 T24012 T24013 det the,loss
R16042 T24013 T24011 pobj loss,to
R16043 T24014 T24013 prep of,loss
R16044 T24015 T24016 poss its,ability
R16045 T24016 T24014 pobj ability,of
R16046 T24017 T24018 aux to,promote
R16047 T24018 T24016 acl promote,ability
R16048 T24019 T24018 dobj necroptosis,promote
R16049 T24020 T24010 punct .,leads
R16050 T24021 T24024 advmod However,were
R16051 T24022 T24024 punct ",",were
R16052 T24023 T24024 nsubj we,were
R16053 T24024 T24024 ROOT were,were
R16054 T24025 T24024 neg not,were
R16055 T24026 T24024 acomp able,were
R16056 T24027 T24028 aux to,confirm
R16057 T24028 T24026 xcomp confirm,able
R16058 T24029 T24028 dobj phosphorylation,confirm
R16059 T24030 T24029 prep of,phosphorylation
R16060 T24031 T24032 det these,residues
R16061 T24032 T24030 pobj residues,of
R16062 T24033 T24029 prep on,phosphorylation
R16063 T24034 T24035 compound endogenous,Akt
R16064 T24035 T24033 pobj Akt,on
R16065 T24036 T24035 prep in,Akt
R16066 T24037 T24038 compound L929,cells
R16067 T24038 T24036 pobj cells,in
R16068 T24039 T24028 advcl using,confirm
R16069 T24040 T24041 preconj either,mass
R16070 T24041 T24055 nmod mass,suggesting
R16071 T24042 T24041 amod spectrometry,mass
R16072 T24043 T24042 cc or,spectrometry
R16073 T24044 T24042 conj western,spectrometry
R16074 T24045 T24042 conj blotting,spectrometry
R16075 T24046 T24045 prep with,blotting
R16076 T24047 T24049 det a,antibody
R16077 T24048 T24049 amod phospho-specific,antibody
R16078 T24049 T24046 pobj antibody,with
R16079 T24050 T24049 acl raised,antibody
R16080 T24051 T24050 prep against,raised
R16081 T24052 T24053 compound Thr435,peptide
R16082 T24053 T24051 pobj peptide,against
R16083 T24054 T24045 punct ",",blotting
R16084 T24055 T24024 advcl suggesting,were
R16085 T24056 T24064 mark that,represents
R16086 T24057 T24058 amod direct,phosphorylation
R16087 T24058 T24064 nsubj phosphorylation,represents
R16088 T24059 T24058 prep of,phosphorylation
R16089 T24060 T24059 pobj Akt,of
R16090 T24061 T24058 prep by,phosphorylation
R16091 T24062 T24061 pobj RIP1,by
R16092 T24063 T24064 advmod likely,represents
R16093 T24064 T24055 advcl represents,suggesting
R16094 T24065 T24066 det an,in
R16095 T24066 T24064 prep in,represents
R16096 T24067 T24068 amod vitro,artifact
R16097 T24068 T24066 pobj artifact,in
R16098 T24069 T24064 cc and,represents
R16099 T24070 T24072 aux does,reflect
R16100 T24071 T24072 neg not,reflect
R16101 T24072 T24064 conj reflect,represents
R16102 T24073 T24074 amod endogenous,regulation
R16103 T24074 T24072 dobj regulation,reflect
R16104 T24075 T24024 punct .,were
R16105 T24076 T24079 advmod Second,are
R16106 T24077 T24079 punct ",",are
R16107 T24078 T24079 attr what,are
R16108 T24079 T24079 ROOT are,are
R16109 T24080 T24082 det the,substrates
R16110 T24081 T24082 amod key,substrates
R16111 T24082 T24079 attr substrates,are
R16112 T24083 T24082 prep of,substrates
R16113 T24084 T24083 pobj Akt,of
R16114 T24085 T24086 nsubj that,promote
R16115 T24086 T24082 relcl promote,substrates
R16116 T24087 T24088 amod necrotic,death
R16117 T24088 T24086 dobj death,promote
R16118 T24089 T24082 cc and,substrates
R16119 T24090 T24091 compound TNFα,synthesis
R16120 T24091 T24082 conj synthesis,substrates
R16121 T24092 T24079 punct ?,are
R16122 T24093 T24100 prep On,suggest
R16123 T24094 T24096 det the,hand
R16124 T24095 T24096 nummod one,hand
R16125 T24096 T24093 pobj hand,On
R16126 T24097 T24100 punct ",",suggest
R16127 T24098 T24099 poss our,data
R16128 T24099 T24100 nsubj data,suggest
R16129 T24100 T24100 ROOT suggest,suggest
R16130 T24101 T24102 amod new,roles
R16131 T24102 T24100 dobj roles,suggest
R16132 T24103 T24102 prep for,roles
R16133 T24104 T24106 nmod Akt,pathways
R16134 T24105 T24106 compound effector,pathways
R16135 T24106 T24103 pobj pathways,for
R16136 T24107 T24106 acl mediated,pathways
R16137 T24108 T24107 agent by,mediated
R16138 T24109 T24108 pobj mTORC1,by
R16139 T24110 T24107 prep in,mediated
R16140 T24111 T24112 amod necroptotic,control
R16141 T24112 T24110 pobj control,in
R16142 T24113 T24100 punct .,suggest
R16143 T24114 T24121 prep On,observed
R16144 T24115 T24117 det the,hand
R16145 T24116 T24117 amod other,hand
R16146 T24117 T24114 pobj hand,On
R16147 T24118 T24121 punct ",",observed
R16148 T24119 T24121 nsubj we,observed
R16149 T24120 T24121 aux have,observed
R16150 T24121 T24121 ROOT observed,observed
R16151 T24122 T24124 advmod only,changes
R16152 T24123 T24124 amod modest,changes
R16153 T24124 T24121 dobj changes,observed
R16154 T24125 T24124 prep in,changes
R16155 T24126 T24127 amod mTORC1,activity
R16156 T24127 T24125 pobj activity,in
R16157 T24128 T24121 prep under,observed
R16158 T24129 T24130 amod necroptotic,conditions
R16159 T24130 T24128 pobj conditions,under
R16160 T24131 T24121 punct ",",observed
R16161 T24132 T24121 advcl suggesting,observed
R16162 T24133 T24137 mark that,are
R16163 T24134 T24136 amod additional,substrates
R16164 T24135 T24136 compound Akt,substrates
R16165 T24136 T24137 nsubj substrates,are
R16166 T24137 T24132 ccomp are,suggesting
R16167 T24138 T24137 acomp likely,are
R16168 T24139 T24141 aux to,involved
R16169 T24140 T24141 auxpass be,involved
R16170 T24141 T24138 xcomp involved,likely
R16171 T24142 T24121 punct .,observed
R16172 T24143 T24144 nsubj This,warrants
R16173 T24144 T24144 ROOT warrants,warrants
R16174 T24145 T24146 det a,re-evaluation
R16175 T24146 T24144 dobj re-evaluation,warrants
R16176 T24147 T24146 prep of,re-evaluation
R16177 T24148 T24149 det the,roles
R16178 T24149 T24147 pobj roles,of
R16179 T24150 T24149 prep of,roles
R16180 T24151 T24153 amod additional,substrates
R16181 T24152 T24153 compound Akt,substrates
R16182 T24153 T24150 pobj substrates,of
R16183 T24154 T24153 prep in,substrates
R16184 T24155 T24156 amod necroptotic,death
R16185 T24156 T24154 pobj death,in
R16186 T24157 T24144 punct ",",warrants
R16187 T24158 T24164 mark since,established
R16188 T24159 T24161 det no,connections
R16189 T24160 T24161 amod such,connections
R16190 T24161 T24164 nsubjpass connections,established
R16191 T24162 T24164 aux have,established
R16192 T24163 T24164 auxpass been,established
R16193 T24164 T24144 advcl established,warrants
R16194 T24165 T24144 punct .,warrants
R16195 T24166 T24174 advmod Similarly,remain
R16196 T24167 T24174 punct ",",remain
R16197 T24168 T24169 det the,mechanisms
R16198 T24169 T24174 nsubj mechanisms,remain
R16199 T24170 T24169 acl connecting,mechanisms
R16200 T24171 T24170 dobj mTORC1,connecting
R16201 T24172 T24170 prep to,connecting
R16202 T24173 T24172 pobj JNK,to
R16203 T24174 T24174 ROOT remain,remain
R16204 T24175 T24177 aux to,elucidated
R16205 T24176 T24177 auxpass be,elucidated
R16206 T24177 T24174 xcomp elucidated,remain
R16207 T24178 T24174 punct .,remain
R16208 T24179 T24181 mark While,are
R16209 T24180 T24181 expl there,are
R16210 T24181 T24204 advcl are,remain
R16211 T24182 T24184 det some,examples
R16212 T24183 T24184 amod recent,examples
R16213 T24184 T24181 attr examples,are
R16214 T24185 T24184 prep of,examples
R16215 T24186 T24187 amod mTORC1-dependent,regulation
R16216 T24187 T24185 pobj regulation,of
R16217 T24188 T24187 prep of,regulation
R16218 T24189 T24188 pobj JNK,of
R16219 T24190 T24187 punct ",",regulation
R16220 T24191 T24187 conj e.g.,regulation
R16221 T24192 T24184 acl following,examples
R16222 T24193 T24194 compound ER,stress
R16223 T24194 T24192 pobj stress,following
R16224 T24195 T24197 nmod [,]
R16225 T24196 T24197 nummod 46,]
R16226 T24197 T24194 dobj ],stress
R16227 T24198 T24197 punct ",",]
R16228 T24199 T24201 det the,mechanisms
R16229 T24200 T24201 amod exact,mechanisms
R16230 T24201 T24197 appos mechanisms,]
R16231 T24202 T24201 prep during,mechanisms
R16232 T24203 T24202 pobj necroptosis,during
R16233 T24204 T24204 ROOT remain,remain
R16234 T24205 T24207 aux to,established
R16235 T24206 T24207 auxpass be,established
R16236 T24207 T24204 xcomp established,remain
R16237 T24208 T24204 punct .,remain
R16238 T24209 T24228 prep Given,is
R16239 T24210 T24211 det the,activation
R16240 T24211 T24209 pobj activation,Given
R16241 T24212 T24211 prep of,activation
R16242 T24213 T24212 pobj JNK,of
R16243 T24214 T24211 prep by,activation
R16244 T24215 T24214 pobj TNFα,by
R16245 T24216 T24215 cc and,TNFα
R16246 T24217 T24218 det the,importance
R16247 T24218 T24211 conj importance,activation
R16248 T24219 T24218 prep of,importance
R16249 T24220 T24222 amod mTORC1-dependent,control
R16250 T24221 T24222 amod translational,control
R16251 T24222 T24219 pobj control,of
R16252 T24223 T24222 prep in,control
R16253 T24224 T24223 pobj necroptosis,in
R16254 T24225 T24228 punct ",",is
R16255 T24226 T24227 nummod one,possibility
R16256 T24227 T24228 nsubj possibility,is
R16257 T24228 T24228 ROOT is,is
R16258 T24229 T24231 mark that,contributes
R16259 T24230 T24231 nsubj mTORC1,contributes
R16260 T24231 T24228 ccomp contributes,is
R16261 T24232 T24231 prep to,contributes
R16262 T24233 T24234 det the,translation
R16263 T24234 T24232 pobj translation,to
R16264 T24235 T24234 prep of,translation
R16265 T24236 T24235 pobj TNFα,of
R16266 T24237 T24234 cc and,translation
R16267 T24238 T24234 conj forms,translation
R16268 T24239 T24241 det a,feed
R16269 T24240 T24241 amod positive,feed
R16270 T24241 T24231 dobj feed,contributes
R16271 T24242 T24243 amod forward,loop
R16272 T24243 T24241 appos loop,feed
R16273 T24244 T24241 prep with,feed
R16274 T24245 T24244 pobj JNK,with
R16275 T24246 T24228 punct .,is

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T23244 2159-2166 Regulation denotes control
T23243 2080-2090 Positive_regulation denotes activation
T23242 2297-2300 Protein denotes JNK
T23241 2248-2252 Protein denotes TNFα
T23240 2207-2213 Protein denotes mTORC1
T23239 2128-2134 Protein denotes mTORC1
T23238 2101-2105 Protein denotes TNFα
T23237 2094-2097 Protein denotes JNK
T23236 1954-1964 Regulation denotes regulation
T23235 1968-1971 Protein denotes JNK
T23234 1868-1871 Protein denotes JNK
T23233 1563-1569 Protein denotes mTORC1
T23232 1439-1442 Protein denotes Akt
T23231 1380-1389 Gene_expression denotes synthesis
T23230 1375-1379 Protein denotes TNFα
T23229 1339-1342 Protein denotes Akt
T23228 1288-1298 Regulation denotes regulation
T23227 1288-1298 Regulation denotes regulation
T23226 1186-1201 Phosphorylation denotes phosphorylation
T23225 1186-1201 Phosphorylation denotes phosphorylation
T23224 1212-1216 Protein denotes RIP1
T23223 1205-1208 Protein denotes Akt
T23222 884-887 Protein denotes Akt
T23221 880-883 Protein denotes Myr
T23220 725-740 Phosphorylation denotes phosphorylation
T23219 725-740 Phosphorylation denotes phosphorylation
T23218 751-774 Protein denotes recombinant RIP1 kinase
T23217 744-747 Protein denotes Akt
T23216 632-635 Protein denotes Akt
T23215 626-630 Protein denotes PDK1
T23214 604-615 Protein denotes RIP1 kinase
T23213 426-432 Regulation denotes effect
T23212 426-432 Regulation denotes effect
T23211 499-509 Positive_regulation denotes activation
T23210 480-495 Phosphorylation denotes phosphorylation
T23209 445-454 Negative_regulation denotes inhibitor
T23208 473-479 Protein denotes Thr308
T23207 440-444 Protein denotes PP2A
T23206 307-311 Protein denotes PP2A
T23205 273-280 Regulation denotes targets
T23204 281-287 Protein denotes Thr308
T23203 233-244 Protein denotes RIP1 kinase
T23202 159-168 Regulation denotes dependent
T23201 169-177 Positive_regulation denotes increase
T23200 192-207 Phosphorylation denotes phosphorylation
T23199 181-184 Protein denotes Akt
T23198 154-158 Protein denotes RIP1
T23197 80-90 Regulation denotes regulation
T23196 94-97 Protein denotes Akt
R15509 T23196 T23197 themeOf Akt,regulation
R15510 T23198 T23202 causeOf RIP1,dependent
R15511 T23199 T23200 themeOf Akt,phosphorylation
R15512 T23200 T23201 themeOf phosphorylation,increase
R15513 T23201 T23202 themeOf increase,dependent
R15514 T23204 T23205 themeOf Thr308,targets
R15515 T23207 T23209 themeOf PP2A,inhibitor
R15516 T23208 T23210 themeOf Thr308,phosphorylation
R15517 T23209 T23212 causeOf inhibitor,effect
R15518 T23209 T23213 causeOf inhibitor,effect
R15519 T23210 T23211 themeOf phosphorylation,activation
R15520 T23210 T23212 themeOf phosphorylation,effect
R15521 T23211 T23213 themeOf activation,effect
R15522 T23217 T23219 themeOf Akt,phosphorylation
R15523 T23218 T23220 themeOf recombinant RIP1 kinase,phosphorylation
R15524 T23223 T23225 themeOf Akt,phosphorylation
R15525 T23224 T23226 themeOf RIP1,phosphorylation
R15526 T23225 T23227 themeOf phosphorylation,regulation
R15527 T23226 T23228 themeOf phosphorylation,regulation
R15528 T23230 T23231 themeOf TNFα,synthesis
R15529 T23235 T23236 themeOf JNK,regulation
R15530 T23237 T23243 themeOf JNK,activation
R15531 T23238 T23243 causeOf TNFα,activation
R15532 T23243 T23244 themeOf activation,control

test3

Id Subject Object Predicate Lexical cue
T20886 2248-2252 Protein denotes TNFα
T20885 2214-2225 Positive_regulation denotes contributes
T20884 2101-2105 Protein denotes TNFα
T20883 1380-1389 Gene_expression denotes synthesis
T20882 1375-1379 Protein denotes TNFα
T20881 1288-1298 Regulation denotes regulation
T20880 1212-1216 Protein denotes RIP1
T20879 1186-1201 Phosphorylation denotes phosphorylation
T20878 982-997 Phosphorylation denotes phosphorylation
T20877 880-887 Protein denotes Myr-Akt
T20876 763-767 Protein denotes RIP1
T20875 725-740 Phosphorylation denotes phosphorylation
T20874 626-630 Protein denotes PDK1
T20873 604-608 Protein denotes RIP1
T20872 480-495 Phosphorylation denotes phosphorylation
T20871 233-237 Protein denotes RIP1
T20870 192-207 Phosphorylation denotes phosphorylation
T20869 169-177 Positive_regulation denotes increase
T20868 159-168 Regulation denotes dependent
T20867 154-158 Protein denotes RIP1
T20866 80-90 Regulation denotes regulation
T20823 2248-2252 Protein denotes TNFα
T20822 2101-2105 Protein denotes TNFα
T20821 1375-1379 Protein denotes TNFα
T20820 1212-1216 Protein denotes RIP1
T20819 880-887 Protein denotes Myr-Akt
T20818 763-767 Protein denotes RIP1
T20817 626-630 Protein denotes PDK1
T20816 604-608 Protein denotes RIP1
T20815 233-237 Protein denotes RIP1
T20814 154-158 Protein denotes RIP1
R13941 T20867 T20868 causeOf RIP1,dependent
R13942 T20867 T20869 causeOf RIP1,increase
R13943 T20869 T20868 themeOf increase,dependent
R13944 T20870 T20869 themeOf phosphorylation,increase
R13945 T20882 T20883 themeOf TNFα,synthesis