PMC:3585731 / 41607-49868 JSON TXT

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testone

Id	Subject	Object	Predicate	Lexical cue
T20806	8035-8042	Positive_regulation	denotes	induced
T20805	7616-7626	Gene_expression	denotes	production
T20804	7606-7615	Positive_regulation	denotes	increased
T20803	7467-7477	Gene_expression	denotes	production
T20802	7085-7094	Gene_expression	denotes	synthesis
T20801	7066-7076	Positive_regulation	denotes	activation
T20800	6300-6310	Gene_expression	denotes	production
T20799	6286-6295	Positive_regulation	denotes	mediating
T20798	6098-6107	Gene_expression	denotes	synthesis
T20797	6081-6089	Positive_regulation	denotes	increase
T20796	5991-6000	Negative_regulation	denotes	deficient
T20795	5361-5368	Positive_regulation	denotes	induced
T20794	4849-4859	Positive_regulation	denotes	activation
T20793	4793-4803	Positive_regulation	denotes	activation
T20792	4130-4140	Positive_regulation	denotes	activation
T20791	4010-4017	Binding	denotes	targets
T20790	3922-3929	Regulation	denotes	targets
T20789	3828-3838	Regulation	denotes	regulation
T20788	2461-2476	Phosphorylation	denotes	phosphorylation
T20787	2257-2272	Phosphorylation	denotes	phosphorylation
T20786	2000-2015	Phosphorylation	denotes	phosphorylation
T20785	1891-1900	Regulation	denotes	targeting
T20784	1847-1855	Positive_regulation	denotes	increase
T20783	1755-1770	Phosphorylation	denotes	phosphorylation
T20782	1720-1729	Negative_regulation	denotes	inhibitor
T20781	1701-1707	Regulation	denotes	effect
T20780	1467-1482	Phosphorylation	denotes	phosphorylation
T20779	1444-1452	Positive_regulation	denotes	increase
T20778	1434-1443	Regulation	denotes	dependent
T20777	1355-1365	Regulation	denotes	regulation
T20776	990-1005	Phosphorylation	denotes	phosphorylation
T20775	901-916	Phosphorylation	denotes	phosphorylation
T20774	881-889	Positive_regulation	denotes	required
T20773	716-726	Gene_expression	denotes	expression
T20772	608-618	Gene_expression	denotes	Expression
T20771	587-599	Localization	denotes	localization
T20770	558-563	Positive_regulation	denotes	leads
T20769	531-538	Positive_regulation	denotes	induced
T20768	451-466	Phosphorylation	denotes	phosphorylation
T20767	201-216	Phosphorylation	denotes	phosphorylation
T20766	185-193	Positive_regulation	denotes	increase
T20765	8178-8182	Protein	denotes	RIP1
T20764	8065-8069	Protein	denotes	RIP1
T20763	7984-7988	Protein	denotes	RIP3
T20762	7975-7979	Protein	denotes	RIP1
T20761	7630-7634	Protein	denotes	TNFα
T20760	7462-7466	Protein	denotes	TNFα
T20759	7382-7391	Protein	denotes	caspase-8
T20758	7373-7377	Protein	denotes	FADD
T20757	7347-7351	Protein	denotes	RIP3
T20756	7342-7346	Protein	denotes	RIP1
T20755	7098-7102	Protein	denotes	RIP1
T20754	7080-7084	Protein	denotes	TNFα
T20753	6314-6318	Protein	denotes	TNFα
T20752	6254-6258	Protein	denotes	RIP1
T20751	6093-6097	Protein	denotes	TNFα
T20750	5986-5990	Protein	denotes	FADD
T20749	5736-5740	Protein	denotes	RIP1
T20748	5372-5376	Protein	denotes	TNFα
T20747	5244-5248	Protein	denotes	TNFα
T20746	4578-4582	Protein	denotes	RIP1
T20745	4073-4077	Protein	denotes	MDM2
T20744	4066-4067	Protein	denotes	4
T20743	4060-4065	Protein	denotes	FoxO1
T20742	3849-3853	Protein	denotes	RIP1
T20741	3523-3527	Protein	denotes	TNFα
T20740	3376-3380	Protein	denotes	TNFα
T20739	2650-2654	Protein	denotes	TNFα
T20738	2487-2491	Protein	denotes	RIP1
T20737	2155-2162	Protein	denotes	Myr-Akt
T20736	2038-2042	Protein	denotes	RIP1
T20735	1901-1905	Protein	denotes	PDK1
T20734	1879-1883	Protein	denotes	RIP1
T20733	1508-1512	Protein	denotes	RIP1
T20732	1429-1433	Protein	denotes	RIP1
T20731	850-854	Protein	denotes	RIP1
T20730	824-828	Protein	denotes	TNFα
T20729	730-737	Protein	denotes	Myr-Akt
T20728	662-669	Protein	denotes	Myr-Akt
T20727	387-391	Protein	denotes	TNFα
T20726	260-264	Protein	denotes	RIP1
T20725	116-120	Protein	denotes	RIP1
R13909	T20728	T20772	themeOf	Myr-Akt,Expression
R13910	T20729	T20773	themeOf	Myr-Akt,expression
R13911	T20731	T20774	causeOf	RIP1,required
R13912	T20732	T20778	causeOf	RIP1,dependent
R13913	T20734	T20784	themeOf	RIP1,increase
R13914	T20736	T20786	causeOf	RIP1,phosphorylation
R13915	T20738	T20788	themeOf	RIP1,phosphorylation
R13916	T20742	T20789	causeOf	RIP1,regulation
R13917	T20748	T20795	causeOf	TNFα,induced
R13918	T20750	T20796	themeOf	FADD,deficient
R13919	T20751	T20798	themeOf	TNFα,synthesis
R13920	T20752	T20799	causeOf	RIP1,mediating
R13921	T20753	T20800	themeOf	TNFα,production
R13922	T20754	T20802	themeOf	TNFα,synthesis
R13923	T20760	T20803	themeOf	TNFα,production
R13924	T20761	T20805	themeOf	TNFα,production
R13925	T20767	T20766	themeOf	phosphorylation,increase
R13926	T20771	T20770	themeOf	localization,leads
R13927	T20775	T20774	themeOf	phosphorylation,required
R13928	T20779	T20778	themeOf	increase,dependent
R13929	T20780	T20779	themeOf	phosphorylation,increase
R13930	T20796	T20797	causeOf	deficient,increase
R13931	T20798	T20797	themeOf	synthesis,increase
R13932	T20800	T20799	themeOf	production,mediating
R13933	T20802	T20801	themeOf	synthesis,activation
R13934	T20805	T20804	themeOf	production,increased

2_test

Id	Subject	Object	Predicate	Lexical cue
23469174-18006659-90505462	1664-1666	18006659	denotes	45
23469174-21779001-90505463	3274-3276	21779001	denotes	46
23469174-18006659-90505464	3763-3765	18006659	denotes	45
23469174-17251378-90505465	3769-3771	17251378	denotes	47
23469174-18006659-90505466	4635-4637	18006659	denotes	45
23469174-17251378-90505467	4670-4672	17251378	denotes	47
23469174-15325584-90505468	4869-4871	15325584	denotes	48
23469174-21127402-90505469	5119-5121	21127402	denotes	11
23469174-15131264-90505470	5125-5127	15131264	denotes	14
23469174-22027097-90505471	5250-5252	22027097	denotes	49
23469174-22695613-90505472	6187-6189	22695613	denotes	15
23469174-21921917-90505473	6541-6542	21921917	denotes	5
23469174-22195746-90505474	6546-6547	22195746	denotes	6
23469174-19109899-90505475	6551-6553	19109899	denotes	10
23469174-20010783-90505476	6715-6716	20010783	denotes	1
23469174-21921917-90505477	6720-6721	21921917	denotes	5
23469174-22195746-90505478	6725-6726	22195746	denotes	6
23469174-16391229-90505479	6730-6732	16391229	denotes	50
23469174-18493258-90505480	6736-6738	18493258	denotes	51
23469174-21804564-90505481	7592-7593	21804564	denotes	4
23469174-21921917-90505482	7597-7598	21921917	denotes	5
23469174-22195746-90505483	8049-8050	22195746	denotes	6

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T22709	8250-8260	NN	denotes	conditions
T22708	8244-8249	DT	denotes	these
T22707	8235-8243	VB	denotes	treating
T22706	8231-8234	IN	denotes	for
T22705	8223-8230	NN	denotes	benefit
T22704	8211-8222	JJ	denotes	therapeutic
T22703	8205-8210	VB	denotes	offer
T22702	8201-8204	MD	denotes	may
T22701	8190-8200	NN	denotes	inhibitors
T22700	8183-8189	NN	denotes	kinase
T22699	8178-8182	NN	denotes	RIP1
T22698	8169-8177	JJ	denotes	specific
T22697	8165-8168	CC	denotes	and
T22696	8155-8164	JJ	denotes	efficient
T22695	8152-8154	IN	denotes	as
T22694	8150-8151	-COMMA-	denotes	,
T22693	8137-8150	NN	denotes	investigation
T22692	8129-8136	JJ	denotes	further
T22691	8120-8128	VB	denotes	warrants
T22690	8111-8119	NN	denotes	diseases
T22689	8098-8110	JJ	denotes	inflammatory
T22688	8090-8097	JJ	denotes	chronic
T22687	8086-8089	CC	denotes	and
T22686	8080-8085	JJ	denotes	acute
T22685	8077-8079	IN	denotes	in
T22684	8070-8076	NN	denotes	kinase
T22683	8065-8069	NN	denotes	RIP1
T22682	8062-8064	IN	denotes	of
T22681	8057-8061	NN	denotes	role
T22680	8053-8056	DT	denotes	The
T22679	8050-8051	-RRB-	denotes	]
T22678	8049-8050	CD	denotes	6
T22677	8048-8049	-LRB-	denotes	[
T22676	8043-8047	NNP	denotes	SIRS
T22675	8031-8042	JJ	denotes	TNF-induced
T22674	8028-8030	IN	denotes	by
T22673	8017-8027	VB	denotes	introduced
T22672	8010-8016	NN	denotes	damage
T22671	8001-8009	JJ	denotes	cellular
T22670	7997-8000	DT	denotes	the
T22669	7989-7996	VB	denotes	mediate
T22668	7984-7988	NN	denotes	RIP3
T22667	7980-7983	CC	denotes	and
T22666	7975-7979	NN	denotes	RIP1
T22665	7970-7974	IN	denotes	that
T22664	7964-7969	VB	denotes	shown
T22663	7960-7963	VB	denotes	has
T22662	7956-7959	FW	denotes	al.
T22661	7953-7955	FW	denotes	et
T22660	7946-7952	NNP	denotes	Duprez
T22586	7492-7495	DT	denotes	the
T22585	7489-7491	IN	denotes	in
T22584	7479-7488	VB	denotes	resulting
T22583	7477-7478	-COMMA-	denotes	,
T22582	7467-7477	NN	denotes	production
T22581	7462-7466	NN	denotes	TNFα
T22580	7458-7461	CC	denotes	and
T22579	7446-7457	NN	denotes	necroptosis
T22578	7443-7445	IN	denotes	of
T22577	7437-7442	NN	denotes	cycle
T22576	7429-7436	JJ	denotes	forward
T22575	7424-7428	NN	denotes	feed
T22574	7422-7423	DT	denotes	a
T22573	7412-7421	VB	denotes	unleashes
T22572	7406-7411	NN	denotes	cells
T22571	7395-7405	JJ	denotes	epithelial
T22570	7392-7394	IN	denotes	in
T22569	7382-7391	NN	denotes	caspase-8
T22568	7378-7381	CC	denotes	and
T22567	7373-7377	NN	denotes	FADD
T22566	7370-7372	IN	denotes	by
T22565	7359-7369	NN	denotes	activities
T22564	7352-7358	NN	denotes	kinase
T22563	7342-7351	NN	denotes	RIP1/RIP3
T22562	7337-7341	IN	denotes	over
T22561	7329-7336	NN	denotes	control
T22560	7326-7328	IN	denotes	of
T22559	7321-7325	NN	denotes	loss
T22558	7317-7320	DT	denotes	the
T22557	7312-7316	IN	denotes	that
T22556	7305-7311	VB	denotes	showed
T22555	7298-7304	NN	denotes	papers
T22554	7291-7297	JJ	denotes	recent
T22553	7287-7290	CD	denotes	Two
T22552	7279-7285	NN	denotes	notion
T22551	7274-7278	DT	denotes	this
T22550	7266-7273	VB	denotes	support
T22549	7263-7265	TO	denotes	to
T22548	7255-7262	VB	denotes	appears
T22547	7250-7254	NN	denotes	data
T22546	7245-7249	FW	denotes	vivo
T22545	7242-7244	FW	denotes	in
T22544	7234-7241	JJ	denotes	Initial
T22543	7223-7232	NN	denotes	signaling
T22542	7210-7222	JJ	denotes	inflammatory
T22541	7199-7209	JJ	denotes	pathologic
T22540	7196-7198	IN	denotes	of
T22539	7185-7195	NN	denotes	inhibition
T22538	7181-7184	DT	denotes	the
T22537	7177-7180	IN	denotes	for
T22536	7170-7176	NN	denotes	target
T22535	7160-7169	JJ	denotes	molecular
T22534	7156-7159	JJ	denotes	new
T22533	7154-7155	DT	denotes	a
T22532	7144-7153	VB	denotes	represent
T22531	7140-7143	MD	denotes	may
T22530	7132-7139	NN	denotes	pathway
T22529	7127-7131	DT	denotes	this
T22528	7125-7126	-COMMA-	denotes	,
T22527	7116-7125	RB	denotes	Therefore
T22526	7107-7114	NN	denotes	kinases
T22525	7098-7106	NN	denotes	RIP1/Akt
T22524	7095-7097	IN	denotes	by
T22523	7085-7094	NN	denotes	synthesis
T22522	7080-7084	NN	denotes	TNFα
T22521	7077-7079	IN	denotes	of
T22520	7066-7076	NN	denotes	activation
T22519	7057-7065	JJ	denotes	specific
T22518	7053-7056	DT	denotes	the
T22517	7050-7052	TO	denotes	to
T22516	7046-7049	JJ	denotes	due
T22515	7034-7045	NN	denotes	necroptosis
T22514	7031-7033	IN	denotes	of
T22513	7021-7030	NN	denotes	component
T22512	7011-7020	VB	denotes	regulated
T22511	7007-7010	CC	denotes	and
T22510	6997-7006	JJ	denotes	intrinsic
T22509	6994-6996	DT	denotes	an
T22508	6991-6993	VB	denotes	is
T22507	6988-6990	PRP	denotes	it
T22506	6983-6987	IN	denotes	that
T22505	6978-6982	RB	denotes	also
T22504	6974-6977	CC	denotes	but
T22503	6972-6973	-COMMA-	denotes	,
T22502	6967-6972	NN	denotes	death
T22501	6962-6966	NN	denotes	cell
T22500	6953-6961	JJ	denotes	necrotic
T22499	6949-6952	IN	denotes	for
T22498	6934-6948	JJ	denotes	characteristic
T22497	6924-6933	NN	denotes	integrity
T22496	6915-6923	NN	denotes	membrane
T22495	6908-6914	NN	denotes	plasma
T22494	6905-6907	IN	denotes	of
T22493	6900-6904	NN	denotes	loss
T22492	6894-6899	JJ	denotes	rapid
T22491	6891-6893	IN	denotes	of
T22490	6884-6890	NN	denotes	virtue
T22489	6880-6883	DT	denotes	the
T22488	6877-6879	IN	denotes	by
T22487	6869-6876	NN	denotes	systems
T22486	6860-6868	JJ	denotes	cellular
T22485	6857-6859	IN	denotes	of
T22484	6849-6856	NN	denotes	variety
T22483	6847-6848	DT	denotes	a
T22482	6844-6846	IN	denotes	in
T22481	6832-6843	NN	denotes	necroptosis
T22480	6820-6831	VB	denotes	accompanies
T22479	6810-6819	RB	denotes	passively
T22478	6805-6809	RB	denotes	only
T22477	6801-6804	RB	denotes	not
T22476	6788-6800	NN	denotes	inflammation
T22475	6783-6787	IN	denotes	that
T22474	6776-6782	NN	denotes	notion
T22473	6766-6775	JJ	denotes	important
T22472	6763-6765	DT	denotes	an
T22471	6753-6762	VB	denotes	highlight
T22470	6745-6752	NN	denotes	results
T22469	6741-6744	PRP-DOLLAR-	denotes	Our
T22468	6738-6739	-RRB-	denotes	]
T22467	6736-6738	CD	denotes	51
T22466	6735-6736	-LRB-	denotes	[
T22465	6733-6734	-COMMA-	denotes	,
T22464	6732-6733	-RRB-	denotes	]
T22463	6730-6732	CD	denotes	50
T22462	6729-6730	-LRB-	denotes	[
T22461	6727-6728	-COMMA-	denotes	,
T22460	6726-6727	-RRB-	denotes	]
T22459	6725-6726	CD	denotes	6
T22458	6724-6725	-LRB-	denotes	[
T22457	6722-6723	-COMMA-	denotes	,
T22456	6721-6722	-RRB-	denotes	]
T22455	6720-6721	CD	denotes	5
T22454	6719-6720	-LRB-	denotes	[
T22453	6717-6718	-COMMA-	denotes	,
T22452	6716-6717	-RRB-	denotes	]
T22451	6715-6716	CD	denotes	1
T22450	6714-6715	-LRB-	denotes	[
T22449	6709-6713	FW	denotes	vivo
T22448	6706-6708	FW	denotes	in
T22447	6702-6705	CC	denotes	and
T22446	6696-6701	FW	denotes	vitro
T22445	6693-6695	FW	denotes	in
T22444	6688-6692	CC	denotes	both
T22443	6686-6687	-COMMA-	denotes	,
T22442	6675-6686	NN	denotes	necroptosis
T22441	6673-6674	-COMMA-	denotes	,
T22440	6666-6673	NN	denotes	subtype
T22439	6656-6665	VB	denotes	regulated
T22438	6652-6655	PRP-DOLLAR-	denotes	its
T22437	6649-6651	IN	denotes	as
T22436	6644-6648	RB	denotes	well
T22435	6641-6643	RB	denotes	as
T22434	6635-6640	NN	denotes	death
T22433	6630-6634	NN	denotes	cell
T22432	6621-6629	JJ	denotes	necrotic
T22431	6618-6620	IN	denotes	of
T22430	6605-6617	NN	denotes	consequences
T22429	6595-6604	JJ	denotes	important
T22428	6590-6594	RB	denotes	most
T22427	6586-6589	DT	denotes	the
T22426	6583-6585	IN	denotes	of
T22425	6579-6582	CD	denotes	one
T22424	6576-6578	VB	denotes	is
T22423	6563-6575	NN	denotes	inflammation
T22422	6556-6562	JJ	denotes	Robust
T22421	6553-6554	-RRB-	denotes	]
T22420	6551-6553	CD	denotes	10
T22419	6550-6551	-LRB-	denotes	[
T22418	6548-6549	-COMMA-	denotes	,
T22417	6547-6548	-RRB-	denotes	]
T22416	6546-6547	CD	denotes	6
T22415	6545-6546	-LRB-	denotes	[
T22414	6543-6544	-COMMA-	denotes	,
T22413	6542-6543	-RRB-	denotes	]
T22412	6541-6542	CD	denotes	5
T22411	6540-6541	-LRB-	denotes	[
T22410	6531-6539	NN	denotes	necrosis
T22409	6521-6530	VB	denotes	regulated
T22408	6518-6520	IN	denotes	of
T22407	6513-6517	NN	denotes	form
T22406	6508-6512	DT	denotes	this
T22405	6495-6507	VB	denotes	accompanying
T22404	6482-6494	RB	denotes	specifically
T22403	6480-6481	-COMMA-	denotes	,
T22402	6471-6480	NN	denotes	signaling
T22401	6458-6470	JJ	denotes	inflammatory
T22400	6448-6457	VB	denotes	increased
T22399	6445-6447	TO	denotes	to
T22398	6441-6444	NN	denotes	Akt
T22397	6438-6440	IN	denotes	of
T22396	6425-6437	NN	denotes	contribution
T22395	6419-6424	JJ	denotes	major
T22394	6415-6418	DT	denotes	the
T22393	6405-6414	VB	denotes	highlight
T22392	6401-6404	CC	denotes	and
T22391	6390-6400	NN	denotes	mechanisms
T22390	6380-6389	NN	denotes	signaling
T22389	6368-6379	JJ	denotes	necroptotic
T22388	6365-6367	IN	denotes	of
T22387	6354-6364	NN	denotes	complexity
T22386	6345-6353	VB	denotes	emerging
T22385	6341-6344	DT	denotes	the
T22384	6331-6340	VB	denotes	emphasize
T22383	6326-6330	NN	denotes	data
T22382	6320-6325	DT	denotes	These
T22381	6314-6318	NN	denotes	TNFα
T22380	6311-6313	IN	denotes	of
T22379	6300-6310	NN	denotes	production
T22378	6296-6299	DT	denotes	the
T22377	6286-6295	VB	denotes	mediating
T22376	6283-6285	IN	denotes	in
T22375	6278-6282	NN	denotes	role
T22374	6268-6277	JJ	denotes	important
T22373	6265-6267	DT	denotes	an
T22372	6259-6264	VB	denotes	plays
T22371	6254-6258	NN	denotes	RIP1
T22206	5278-5288	NN	denotes	inhibition
T22205	5274-5277	DT	denotes	the
T22204	5269-5273	IN	denotes	that
T22203	5260-5268	VB	denotes	suggests
T22202	5255-5259	DT	denotes	This
T22201	5252-5253	-RRB-	denotes	]
T22200	5250-5252	CD	denotes	49
T22199	5249-5250	-LRB-	denotes	[
T22198	5244-5248	NN	denotes	TNFα
T22197	5241-5243	IN	denotes	by
T22196	5229-5240	NN	denotes	necroptosis
T22195	5220-5228	VB	denotes	promotes
T22194	5210-5219	NN	denotes	autophagy
T22193	5207-5209	IN	denotes	of
T22192	5195-5206	NN	denotes	inihibition
T22191	5190-5194	IN	denotes	that
T22190	5184-5189	VB	denotes	found
T22189	5179-5183	VB	denotes	have
T22188	5177-5178	-COMMA-	denotes	,
T22187	5173-5177	NN	denotes	data
T22186	5161-5172	JJ	denotes	unpublished
T22185	5158-5160	IN	denotes	in
T22184	5148-5157	PRP	denotes	ourselves
T22183	5138-5147	VB	denotes	including
T22182	5136-5137	-COMMA-	denotes	,
T22181	5130-5136	NN	denotes	Others
T22180	5127-5128	-RRB-	denotes	]
T22179	5125-5127	CD	denotes	14
T22178	5124-5125	-LRB-	denotes	[
T22177	5122-5123	-COMMA-	denotes	,
T22176	5121-5122	-RRB-	denotes	]
T22175	5119-5121	CD	denotes	11
T22174	5118-5119	-LRB-	denotes	[
T22173	5112-5117	NN	denotes	cells
T22172	5107-5111	NN	denotes	L929
T22171	5104-5106	IN	denotes	in
T22170	5095-5103	NN	denotes	zVAD.fmk
T22169	5092-5094	IN	denotes	by
T22168	5084-5091	VB	denotes	induced
T22167	5072-5083	NN	denotes	necroptosis
T22166	5063-5071	VB	denotes	promotes
T22165	5053-5062	NN	denotes	autophagy
T22164	5050-5052	IN	denotes	of
T22163	5039-5049	NN	denotes	activation
T22162	5034-5038	IN	denotes	that
T22161	5024-5033	VB	denotes	suggested
T22160	5016-5023	NN	denotes	studies
T22159	5008-5015	JJ	denotes	Several
T22158	4996-5006	NN	denotes	situations
T22157	4988-4995	JJ	denotes	various
T22156	4985-4987	IN	denotes	in
T22155	4973-4984	NN	denotes	necroptosis
T22154	4965-4972	VB	denotes	inhibit
T22153	4961-4964	CC	denotes	and
T22152	4953-4960	VB	denotes	promote
T22151	4948-4952	CC	denotes	both
T22150	4944-4947	MD	denotes	can
T22149	4941-4943	PRP	denotes	it
T22148	4937-4940	CC	denotes	and
T22147	4929-4936	JJ	denotes	complex
T22146	4924-4928	RB	denotes	very
T22145	4921-4923	VB	denotes	is
T22144	4913-4920	JJ	denotes	general
T22143	4910-4912	IN	denotes	in
T22142	4904-4909	NN	denotes	death
T22141	4899-4903	NN	denotes	cell
T22140	4896-4898	IN	denotes	in
T22139	4886-4895	NN	denotes	autophagy
T22138	4883-4885	IN	denotes	of
T22137	4878-4882	NN	denotes	role
T22136	4874-4877	DT	denotes	The
T22135	4871-4872	-RRB-	denotes	]
T22134	4869-4871	CD	denotes	48
T22133	4868-4869	-LRB-	denotes	[
T22132	4863-4867	NN	denotes	mTOR
T22131	4860-4862	IN	denotes	of
T22130	4849-4859	NN	denotes	activation
T22129	4841-4848	IN	denotes	through
T22128	4831-4840	NN	denotes	autophagy
T22127	4828-4830	IN	denotes	of
T22126	4817-4827	NN	denotes	inhibition
T22125	4813-4816	DT	denotes	the
T22124	4810-4812	TO	denotes	to
T22123	4804-4809	VB	denotes	leads
T22122	4793-4803	NN	denotes	activation
T22121	4789-4792	NN	denotes	Akt
T22120	4778-4787	JJ	denotes	autophagy
T22119	4775-4777	VB	denotes	is
T22118	4771-4774	NN	denotes	Akt
T22117	4768-4770	IN	denotes	by
T22116	4762-4767	NN	denotes	death
T22115	4757-4761	NN	denotes	cell
T22114	4754-4756	IN	denotes	of
T22113	4743-4753	NN	denotes	regulation
T22112	4739-4742	DT	denotes	the
T22111	4734-4738	IN	denotes	with
T22110	4722-4733	NN	denotes	conjunction
T22109	4719-4721	IN	denotes	in
T22108	4708-4718	VB	denotes	considered
T22107	4705-4707	VB	denotes	be
T22106	4698-4704	MD	denotes	should
T22105	4693-4697	WDT	denotes	that
T22104	4683-4692	NN	denotes	mechanism
T22103	4675-4682	DT	denotes	Another
T22102	4672-4673	-RRB-	denotes	]
T22101	4670-4672	CD	denotes	47
T22100	4669-4670	-LRB-	denotes	[
T22099	4662-4668	NN	denotes	stress
T22098	4652-4661	JJ	denotes	metabolic
T22097	4642-4651	JJ	denotes	excessive
T22096	4639-4641	CC	denotes	or
T22095	4637-4638	-RRB-	denotes	]
T22094	4635-4637	CD	denotes	45
T22093	4634-4635	-LRB-	denotes	[
T22092	4626-4633	NN	denotes	factors
T22091	4616-4625	JJ	denotes	oncogenic
T22090	4605-4615	JJ	denotes	particular
T22089	4602-4604	IN	denotes	of
T22088	4591-4601	NN	denotes	expression
T22087	4589-4590	-COMMA-	denotes	,
T22086	4583-4589	NN	denotes	kinase
T22085	4578-4582	NN	denotes	RIP1
T22084	4575-4577	IN	denotes	of
T22083	4568-4574	NN	denotes	status
T22082	4564-4567	DT	denotes	the
T22081	4561-4563	IN	denotes	as
T22080	4556-4560	JJ	denotes	such
T22079	4554-4555	-COMMA-	denotes	,
T22078	4548-4554	NN	denotes	inputs
T22077	4532-4547	JJ	denotes	Akt-independent
T22076	4530-4531	-COMMA-	denotes	,
T22075	4520-4530	JJ	denotes	additional
T22074	4517-4519	IN	denotes	on
T22073	4510-4516	VB	denotes	depend
T22072	4506-4509	MD	denotes	may
T22071	4500-4505	NN	denotes	death
T22070	4496-4499	CC	denotes	and
T22069	4487-4495	NN	denotes	survival
T22068	4479-4486	IN	denotes	between
T22067	4470-4478	NN	denotes	decision
T22066	4464-4469	JJ	denotes	final
T22065	4460-4463	DT	denotes	The
T22064	4453-4458	NN	denotes	death
T22063	4448-4452	NN	denotes	cell
T22062	4434-4447	JJ	denotes	non-apoptotic
T22061	4431-4433	TO	denotes	to
T22060	4422-4430	NN	denotes	survival
T22059	4417-4421	IN	denotes	from
T22058	4409-4416	VB	denotes	ranging
T22057	4407-4408	-COMMA-	denotes	,
T22056	4398-4407	NN	denotes	apoptosis
T22055	4395-4397	TO	denotes	to
T22054	4383-4394	JJ	denotes	alternative
T22053	4377-4382	NN	denotes	fates
T22052	4372-4376	NN	denotes	cell
T22051	4364-4371	VB	denotes	promote
T22050	4361-4363	TO	denotes	to
T22049	4352-4360	VB	denotes	function
T22048	4348-4351	MD	denotes	may
T22047	4340-4347	NN	denotes	pathway
T22046	4336-4339	NN	denotes	Akt
T22045	4332-4335	DT	denotes	the
T22044	4330-4331	-COMMA-	denotes	,
T22043	4326-4330	NN	denotes	role
T22042	4313-4325	JJ	denotes	pro-survival
T22041	4301-4312	RB	denotes	universally
T22040	4299-4300	DT	denotes	a
T22039	4291-4298	VB	denotes	serving
T22038	4286-4290	IN	denotes	than
T22037	4279-4285	RB	denotes	rather
T22036	4274-4278	IN	denotes	that
T22035	4264-4273	VB	denotes	speculate
T22034	4261-4263	TO	denotes	to
T22033	4252-4260	VB	denotes	tempting
T22032	4249-4251	VB	denotes	is
T22031	4246-4248	PRP	denotes	It
T22030	4239-4244	NN	denotes	death
T22029	4234-4238	NN	denotes	cell
T22028	4229-4233	JJ	denotes	more
T22027	4226-4228	TO	denotes	to
T22026	4221-4225	VB	denotes	lead
T22025	4216-4220	MD	denotes	will
T22024	4205-4215	NN	denotes	inhibition
T22023	4201-4204	PRP-DOLLAR-	denotes	its
T22022	4196-4200	IN	denotes	that
T22021	4192-4195	CC	denotes	nor
T22020	4182-4191	NN	denotes	signaling
T22019	4169-4181	JJ	denotes	pro-survival
T22018	4160-4168	VB	denotes	reflects
T22017	4148-4159	RB	denotes	universally
T22659	7943-7945	IN	denotes	by
T22658	7937-7942	NN	denotes	paper
T22657	7930-7936	JJ	denotes	recent
T22656	7922-7929	DT	denotes	another
T22655	7920-7921	-COMMA-	denotes	,
T22654	7915-7920	NN	denotes	lines
T22653	7909-7914	DT	denotes	these
T22652	7903-7908	IN	denotes	Along
T22651	7896-7901	NN	denotes	death
T22650	7888-7895	NN	denotes	patient
T22649	7884-7887	CC	denotes	and
T22648	7876-7883	NN	denotes	failure
T22647	7870-7875	NN	denotes	organ
T22646	7861-7869	JJ	denotes	multiple
T22645	7858-7860	IN	denotes	of
T22644	7852-7857	NN	denotes	cause
T22643	7844-7851	JJ	denotes	primary
T22642	7840-7843	DT	denotes	the
T22641	7837-7839	VB	denotes	is
T22640	7831-7836	NN	denotes	death
T22639	7826-7830	NN	denotes	cell
T22638	7817-7825	JJ	denotes	necrotic
T22637	7804-7816	VB	denotes	accompanying
T22636	7791-7803	NN	denotes	inflammation
T22635	7779-7790	JJ	denotes	hyper-acute
T22634	7773-7778	WRB	denotes	where
T22633	7771-7772	-COMMA-	denotes	,
T22632	7761-7771	NN	denotes	infections
T22631	7751-7760	JJ	denotes	bacterial
T22630	7745-7750	JJ	denotes	acute
T22629	7741-7744	CC	denotes	and
T22628	7728-7740	NN	denotes	pancreatitis
T22627	7716-7727	VB	denotes	necrotizing
T22626	7713-7715	IN	denotes	as
T22625	7708-7712	JJ	denotes	such
T22624	7706-7707	-COMMA-	denotes	,
T22623	7698-7706	NN	denotes	diseases
T22622	7686-7697	VB	denotes	necrotizing
T22621	7680-7685	JJ	denotes	acute
T22620	7676-7679	IN	denotes	for
T22619	7666-7675	JJ	denotes	important
T22618	7663-7665	VB	denotes	be
T22617	7658-7662	RB	denotes	also
T22616	7654-7657	MD	denotes	may
T22615	7642-7653	NN	denotes	necroptosis
T22614	7635-7641	IN	denotes	during
T22613	7630-7634	NN	denotes	TNFα
T22612	7627-7629	IN	denotes	of
T22611	7616-7626	NN	denotes	production
T22610	7606-7615	VB	denotes	increased
T22609	7601-7605	DT	denotes	This
T22608	7598-7599	-RRB-	denotes	]
T22607	7597-7598	CD	denotes	5
T22606	7596-7597	-LRB-	denotes	[
T22605	7594-7595	-COMMA-	denotes	,
T22604	7593-7594	-RRB-	denotes	]
T22603	7592-7593	CD	denotes	4
T22602	7591-7592	-LRB-	denotes	[
T22601	7583-7590	NN	denotes	disease
T22600	7575-7582	NN	denotes	Crohn’s
T22599	7570-7574	IN	denotes	with
T22598	7561-7569	NN	denotes	patients
T22597	7558-7560	IN	denotes	in
T22596	7556-7557	-COMMA-	denotes	,
T22595	7548-7556	RB	denotes	possibly
T22594	7546-7547	-COMMA-	denotes	,
T22593	7543-7546	CC	denotes	and
T22592	7538-7542	NN	denotes	mice
T22591	7535-7537	IN	denotes	in
T22590	7522-7534	NN	denotes	inflammation
T22589	7511-7521	JJ	denotes	intestinal
T22588	7508-7510	IN	denotes	of
T22587	7496-7507	NN	denotes	development
T22016	4144-4147	NN	denotes	Akt
T22015	4141-4143	IN	denotes	of
T22014	4130-4140	NN	denotes	activation
T22013	4125-4129	IN	denotes	that
T22012	4118-4124	VB	denotes	assume
T22011	4115-4117	TO	denotes	to
T22010	4110-4114	JJ	denotes	safe
T22009	4107-4109	VB	denotes	be
T22008	4100-4106	RB	denotes	longer
T22007	4097-4099	RB	denotes	no
T22006	4093-4096	MD	denotes	may
T22005	4090-4092	PRP	denotes	it
T22004	4088-4089	-COMMA-	denotes	,
T22003	4079-4088	RB	denotes	Therefore
T22002	4073-4077	NN	denotes	MDM2
T22001	4069-4072	CC	denotes	and
T22000	4067-4068	-COMMA-	denotes	,
T21999	4060-4067	NN	denotes	FoxO1/4
T21998	4058-4059	-COMMA-	denotes	,
T21997	4053-4058	NN	denotes	GSK-3
T21996	4051-4052	-COMMA-	denotes	,
T21995	4040-4051	RB	denotes	potentially
T21994	4036-4039	CC	denotes	and
T21993	4034-4035	-COMMA-	denotes	,
T21992	4028-4034	NN	denotes	mTORC1
T21991	4018-4027	VB	denotes	including
T21944	3754-3756	RB	denotes	as
T21943	3747-3753	VB	denotes	emerge
T21942	3744-3746	TO	denotes	to
T21941	3738-3743	VB	denotes	begun
T21940	3734-3737	VB	denotes	has
T21939	3720-3733	NN	denotes	circumstances
T21938	3712-3719	JJ	denotes	various
T21937	3706-3711	IN	denotes	under
T21936	3700-3705	NN	denotes	death
T21935	3695-3699	NN	denotes	cell
T21934	3692-3694	IN	denotes	of
T21933	3683-3691	NN	denotes	mediator
T21932	3681-3682	DT	denotes	a
T21931	3678-3680	IN	denotes	as
T21930	3665-3677	NN	denotes	contribution
T21929	3661-3664	PRP-DOLLAR-	denotes	its
T21928	3658-3660	IN	denotes	of
T21927	3649-3657	NN	denotes	evidence
T21926	3647-3648	-COMMA-	denotes	,
T21925	3640-3647	RB	denotes	however
T21924	3638-3639	-COMMA-	denotes	,
T21923	3628-3638	VB	denotes	documented
T21922	3623-3627	RB	denotes	well
T21921	3620-3622	VB	denotes	is
T21920	3610-3619	NN	denotes	apoptosis
T21919	3607-3609	IN	denotes	of
T21918	3597-3606	NN	denotes	inhibitor
T21917	3593-3596	JJ	denotes	key
T21916	3591-3592	DT	denotes	a
T21915	3588-3590	IN	denotes	as
T21914	3583-3587	NN	denotes	role
T21913	3577-3582	NN	denotes	Akt’s
T21912	3572-3575	NN	denotes	JNK
T21911	3567-3571	IN	denotes	with
T21910	3562-3566	NN	denotes	loop
T21909	3554-3561	RB	denotes	forward
T21908	3549-3553	NN	denotes	feed
T21907	3540-3548	JJ	denotes	positive
T21906	3538-3539	DT	denotes	a
T21905	3532-3537	VB	denotes	forms
T21904	3528-3531	CC	denotes	and
T21903	3523-3527	NN	denotes	TNFα
T21902	3520-3522	IN	denotes	of
T21901	3508-3519	NN	denotes	translation
T21900	3504-3507	DT	denotes	the
T21899	3501-3503	TO	denotes	to
T21898	3489-3500	VB	denotes	contributes
T21897	3482-3488	NN	denotes	mTORC1
T21896	3477-3481	IN	denotes	that
T21895	3474-3476	VB	denotes	is
T21894	3462-3473	NN	denotes	possibility
T21893	3458-3461	CD	denotes	one
T21892	3456-3457	-COMMA-	denotes	,
T21891	3445-3456	NN	denotes	necroptosis
T21890	3442-3444	IN	denotes	in
T21889	3434-3441	NN	denotes	control
T21888	3420-3433	JJ	denotes	translational
T21887	3403-3419	JJ	denotes	mTORC1-dependent
T21886	3400-3402	IN	denotes	of
T21885	3389-3399	NN	denotes	importance
T21884	3385-3388	DT	denotes	the
T21883	3381-3384	CC	denotes	and
T21882	3376-3380	NN	denotes	TNFα
T21881	3373-3375	IN	denotes	by
T21880	3369-3372	NN	denotes	JNK
T21879	3366-3368	IN	denotes	of
T21878	3355-3365	NN	denotes	activation
T21877	3351-3354	DT	denotes	the
T21876	3345-3350	VB	denotes	Given
T21875	3332-3343	VB	denotes	established
T21874	3329-3331	VB	denotes	be
T21873	3326-3328	TO	denotes	to
T21872	3319-3325	VB	denotes	remain
T21871	3307-3318	NN	denotes	necroptosis
T21870	3300-3306	IN	denotes	during
T21869	3289-3299	NN	denotes	mechanisms
T21868	3283-3288	JJ	denotes	exact
T21867	3279-3282	DT	denotes	the
T21866	3277-3278	-COMMA-	denotes	,
T21865	3276-3277	-RRB-	denotes	]
T21864	3274-3276	CD	denotes	46
T21863	3273-3274	-LRB-	denotes	[
T21862	3266-3272	NN	denotes	stress
T21861	3263-3265	NN	denotes	ER
T21860	3253-3262	VB	denotes	following
T21859	3248-3252	FW	denotes	e.g.
T21858	3246-3247	-COMMA-	denotes	,
T21857	3243-3246	NN	denotes	JNK
T21856	3240-3242	IN	denotes	of
T21855	3229-3239	NN	denotes	regulation
T21854	3212-3228	JJ	denotes	mTORC1-dependent
T21853	3209-3211	IN	denotes	of
T21852	3200-3208	NN	denotes	examples
T21851	3193-3199	JJ	denotes	recent
T21850	3188-3192	DT	denotes	some
T21849	3184-3187	VB	denotes	are
T21848	3178-3183	EX	denotes	there
T21847	3172-3177	IN	denotes	While
T21846	3160-3170	VB	denotes	elucidated
T21845	3157-3159	VB	denotes	be
T21844	3154-3156	TO	denotes	to
T21843	3147-3153	VB	denotes	remain
T21842	3143-3146	NN	denotes	JNK
T21841	3140-3142	TO	denotes	to
T21840	3133-3139	NN	denotes	mTORC1
T21839	3122-3132	VB	denotes	connecting
T21838	3111-3121	NN	denotes	mechanisms
T21837	3107-3110	DT	denotes	the
T21836	3105-3106	-COMMA-	denotes	,
T21835	3096-3105	RB	denotes	Similarly
T21834	3083-3094	VB	denotes	established
T21833	3078-3082	VB	denotes	been
T21832	3073-3077	VB	denotes	have
T21831	3061-3072	NN	denotes	connections
T21830	3056-3060	JJ	denotes	such
T21829	3053-3055	DT	denotes	no
T21828	3047-3052	IN	denotes	since
T21827	3045-3046	-COMMA-	denotes	,
T21826	3040-3045	NN	denotes	death
T21825	3028-3039	JJ	denotes	necroptotic
T21824	3025-3027	IN	denotes	in
T21823	3014-3024	NN	denotes	substrates
T21822	3010-3013	NN	denotes	Akt
T21821	2999-3009	JJ	denotes	additional
T21820	2996-2998	IN	denotes	of
T21819	2990-2995	NN	denotes	roles
T21818	2986-2989	DT	denotes	the
T21817	2983-2985	IN	denotes	of
T21816	2969-2982	NN	denotes	re-evaluation
T21815	2967-2968	DT	denotes	a
T21814	2958-2966	VB	denotes	warrants
T21813	2953-2957	DT	denotes	This
T21812	2943-2951	VB	denotes	involved
T21811	2940-2942	VB	denotes	be
T21810	2937-2939	TO	denotes	to
T21809	2930-2936	JJ	denotes	likely
T21808	2926-2929	VB	denotes	are
T21807	2915-2925	NN	denotes	substrates
T21806	2911-2914	NN	denotes	Akt
T21805	2900-2910	JJ	denotes	additional
T21804	2895-2899	IN	denotes	that
T21803	2884-2894	VB	denotes	suggesting
T21802	2882-2883	-COMMA-	denotes	,
T21801	2872-2882	NN	denotes	conditions
T21800	2860-2871	JJ	denotes	necroptotic
T21799	2854-2859	IN	denotes	under
T21798	2845-2853	NN	denotes	activity
T21797	2838-2844	NN	denotes	mTORC1
T21796	2835-2837	IN	denotes	in
T21795	2827-2834	NN	denotes	changes
T21794	2820-2826	JJ	denotes	modest
T21793	2815-2819	RB	denotes	only
T21792	2806-2814	VB	denotes	observed
T21791	2801-2805	VB	denotes	have
T21790	2798-2800	PRP	denotes	we
T21789	2796-2797	-COMMA-	denotes	,
T21788	2792-2796	NN	denotes	hand
T21787	2786-2791	JJ	denotes	other
T21786	2782-2785	DT	denotes	the
T21785	2779-2781	IN	denotes	On
T21784	2770-2777	NN	denotes	control
T21783	2758-2769	JJ	denotes	necroptotic
T21782	2755-2757	IN	denotes	in
T21781	2748-2754	NN	denotes	mTORC1
T21780	2745-2747	IN	denotes	by
T21779	2736-2744	VB	denotes	mediated
T21778	2727-2735	NN	denotes	pathways
T21777	2718-2726	NN	denotes	effector
T21776	2714-2717	NN	denotes	Akt
T21775	2710-2713	IN	denotes	for
T21774	2704-2709	NN	denotes	roles
T21773	2700-2703	JJ	denotes	new
T21772	2692-2699	VB	denotes	suggest
T21771	2687-2691	NN	denotes	data
T21770	2683-2686	PRP-DOLLAR-	denotes	our
T21769	2681-2682	-COMMA-	denotes	,
T21768	2677-2681	NN	denotes	hand
T21767	2673-2676	CD	denotes	one
T21766	2669-2672	DT	denotes	the
T21765	2666-2668	IN	denotes	On
T21764	2655-2664	NN	denotes	synthesis
T21763	2650-2654	NN	denotes	TNFα
T21762	2646-2649	CC	denotes	and
T21761	2640-2645	NN	denotes	death
T21760	2631-2639	JJ	denotes	necrotic
T21759	2623-2630	VB	denotes	promote
T21758	2618-2622	WDT	denotes	that
T21757	2614-2617	NN	denotes	Akt
T21756	2611-2613	IN	denotes	of
T21755	2600-2610	NN	denotes	substrates
T22370	6252-6253	-COMMA-	denotes	,
T22369	6241-6252	NN	denotes	necroptosis
T22368	6238-6240	IN	denotes	in
T22367	6233-6237	NN	denotes	role
T22366	6229-6232	PRP-DOLLAR-	denotes	its
T22365	6226-6228	TO	denotes	to
T22364	6217-6225	NN	denotes	addition
T22363	6214-6216	IN	denotes	in
T22362	6212-6213	-COMMA-	denotes	,
T22361	6208-6212	IN	denotes	that
T22360	6195-6207	VB	denotes	demonstrated
T22359	6191-6194	VB	denotes	has
T22358	6189-6190	-RRB-	denotes	]
T22357	6187-6189	CD	denotes	15
T22356	6186-6187	-LRB-	denotes	[
T22355	6180-6185	NN	denotes	study
T22354	6173-6179	JJ	denotes	recent
T22353	6171-6172	DT	denotes	A
T22352	6164-6169	NN	denotes	cells
T22351	6159-6163	NN	denotes	L929
T22350	6156-6158	IN	denotes	in
T22349	6151-6155	NN	denotes	role
T22348	6147-6150	PRP-DOLLAR-	denotes	its
T22347	6140-6146	IN	denotes	unlike
T22346	6138-6139	-COMMA-	denotes	,
T22345	6136-6138	FW	denotes	se
T22344	6132-6135	FW	denotes	per
T22343	6126-6131	NN	denotes	death
T22342	6121-6125	NN	denotes	cell
T22341	6116-6120	IN	denotes	than
T22340	6109-6115	RB	denotes	rather
T22339	6107-6108	-COMMA-	denotes	,
T22338	6098-6107	NN	denotes	synthesis
T22337	6093-6097	NN	denotes	TNFα
T22336	6090-6092	IN	denotes	in
T22335	6081-6089	NN	denotes	increase
T22334	6078-6080	DT	denotes	an
T22333	6075-6077	TO	denotes	to
T22332	6063-6074	RB	denotes	prominently
T22331	6058-6062	RB	denotes	more
T22330	6046-6057	VB	denotes	contributed
T22329	6036-6045	NN	denotes	signaling
T22328	6032-6035	NN	denotes	Akt
T22327	6030-6031	-COMMA-	denotes	,
T22326	6019-6030	NN	denotes	macrophages
T22325	6015-6018	CC	denotes	and
T22324	6013-6014	-COMMA-	denotes	,
T22323	6008-6013	NN	denotes	cells
T22322	6001-6007	NN	denotes	Jurkat
T22321	5986-6000	JJ	denotes	FADD-deficient
T22320	5984-5985	-COMMA-	denotes	,
T22319	5973-5984	NN	denotes	fibroblasts
T22318	5968-5972	NN	denotes	lung
T22317	5962-5967	NN	denotes	mouse
T22316	5959-5961	IN	denotes	in
T22315	5957-5958	-COMMA-	denotes	,
T22314	5946-5957	RB	denotes	Importantly
T22313	5937-5944	NN	denotes	fashion
T22312	5928-5936	JJ	denotes	specific
T22311	5923-5927	NN	denotes	type
T22310	5918-5922	NN	denotes	cell
T22309	5916-5917	DT	denotes	a
T22308	5913-5915	IN	denotes	in
T22307	5906-5912	VB	denotes	varies
T22306	5895-5905	NN	denotes	connection
T22305	5890-5894	DT	denotes	this
T22304	5887-5889	IN	denotes	of
T22303	5874-5886	NN	denotes	significance
T22302	5870-5873	DT	denotes	the
T22301	5868-5869	-COMMA-	denotes	,
T22300	5864-5868	NN	denotes	time
T22299	5859-5863	JJ	denotes	same
T22298	5855-5858	DT	denotes	the
T22297	5852-5854	IN	denotes	At
T22296	5845-5850	NN	denotes	types
T22295	5840-5844	NN	denotes	cell
T22294	5831-5839	JJ	denotes	multiple
T22293	5828-5830	IN	denotes	in
T22292	5819-5827	VB	denotes	observed
T22291	5816-5818	VB	denotes	is
T22290	5811-5815	WDT	denotes	that
T22289	5801-5810	NN	denotes	signaling
T22288	5789-5800	JJ	denotes	necroptotic
T22287	5786-5788	IN	denotes	of
T22286	5778-5785	NN	denotes	feature
T22285	5770-5777	JJ	denotes	general
T22284	5768-5769	DT	denotes	a
T22283	5765-5767	VB	denotes	is
T22282	5761-5764	NN	denotes	Akt
T22281	5758-5760	TO	denotes	to
T22280	5748-5757	NN	denotes	signaling
T22279	5741-5747	NN	denotes	kinase
T22278	5736-5740	NN	denotes	RIP1
T22277	5731-5735	IN	denotes	that
T22276	5722-5730	VB	denotes	revealed
T22275	5717-5721	NN	denotes	data
T22274	5713-5716	PRP-DOLLAR-	denotes	our
T22273	5711-5712	-COMMA-	denotes	,
T22272	5700-5711	RB	denotes	Importantly
T22271	5691-5698	NN	denotes	pathway
T22270	5687-5690	NN	denotes	Akt
T22269	5684-5686	IN	denotes	by
T22268	5672-5683	NN	denotes	necroptosis
T22267	5661-5671	NN	denotes	regulation
T22266	5657-5660	DT	denotes	the
T22265	5654-5656	IN	denotes	in
T22264	5649-5653	NN	denotes	role
T22263	5645-5648	PRP-DOLLAR-	denotes	its
T22262	5634-5644	VB	denotes	understand
T22261	5627-5633	RB	denotes	better
T22260	5624-5626	TO	denotes	to
T22259	5615-5623	VB	denotes	required
T22258	5612-5614	VB	denotes	is
T22257	5606-5611	NN	denotes	cells
T22256	5596-5605	JJ	denotes	mammalian
T22255	5593-5595	IN	denotes	in
T22254	5583-5592	NN	denotes	autophagy
T22253	5570-5582	JJ	denotes	pro-survival
T22252	5566-5569	CC	denotes	and
T22251	5556-5565	JJ	denotes	pro-death
T22250	5548-5555	IN	denotes	between
T22249	5532-5547	VB	denotes	differentiating
T22248	5524-5531	NN	denotes	factors
T22247	5520-5523	DT	denotes	the
T22246	5517-5519	IN	denotes	of
T22245	5502-5516	NN	denotes	identification
T22244	5494-5501	JJ	denotes	further
T22243	5492-5493	-COMMA-	denotes	,
T22242	5485-5492	RB	denotes	Clearly
T22241	5478-5483	NN	denotes	death
T22240	5465-5477	JJ	denotes	zVAD-induced
T22239	5462-5464	IN	denotes	in
T22238	5453-5461	NN	denotes	proteins
T22237	5447-5452	DT	denotes	these
T22236	5444-5446	IN	denotes	of
T22235	5439-5443	NN	denotes	role
T22234	5430-5438	JJ	denotes	positive
T22233	5426-5429	DT	denotes	the
T22232	5421-5425	IN	denotes	with
T22231	5411-5420	VB	denotes	reconcile
T22230	5408-5410	TO	denotes	to
T22229	5398-5407	JJ	denotes	difficult
T22228	5393-5397	RB	denotes	more
T22227	5390-5392	VB	denotes	is
T22226	5387-5389	PRP	denotes	it
T22225	5385-5386	-COMMA-	denotes	,
T22224	5378-5385	RB	denotes	however
T22223	5376-5377	-COMMA-	denotes	,
T22222	5372-5376	NN	denotes	TNFα
T22221	5369-5371	IN	denotes	by
T22220	5361-5368	VB	denotes	induced
T22219	5349-5360	NN	denotes	necroptosis
T22218	5346-5348	TO	denotes	to
T22217	5335-5345	VB	denotes	contribute
T22216	5331-5334	MD	denotes	may
T22215	5324-5330	NN	denotes	system
T22214	5320-5323	PRP-DOLLAR-	denotes	our
T22213	5317-5319	IN	denotes	in
T22212	5312-5316	NN	denotes	mTOR
T22211	5309-5311	CC	denotes	or
T22210	5305-5308	NN	denotes	Akt
T22209	5302-5304	IN	denotes	by
T22208	5292-5301	NN	denotes	autophagy
T22207	5289-5291	IN	denotes	of
T21754	2596-2599	JJ	denotes	key
T21753	2592-2595	DT	denotes	the
T21752	2588-2591	VB	denotes	are
T21751	2583-2587	WP	denotes	what
T21750	2581-2582	-COMMA-	denotes	,
T21749	2575-2581	RB	denotes	Second
T21748	2563-2573	NN	denotes	regulation
T21747	2552-2562	JJ	denotes	endogenous
T21746	2544-2551	VB	denotes	reflect
T21745	2540-2543	RB	denotes	not
T21744	2535-2539	VB	denotes	does
T21743	2531-2534	CC	denotes	and
T21742	2522-2530	NN	denotes	artifact
T21741	2516-2521	FW	denotes	vitro
T21740	2513-2515	FW	denotes	in
T21739	2510-2512	DT	denotes	an
T21738	2499-2509	VB	denotes	represents
T21737	2492-2498	RB	denotes	likely
T21736	2487-2491	NN	denotes	RIP1
T21735	2484-2486	IN	denotes	by
T21734	2480-2483	NN	denotes	Akt
T21733	2477-2479	IN	denotes	of
T21732	2461-2476	NN	denotes	phosphorylation
T21731	2454-2460	JJ	denotes	direct
T21730	2449-2453	IN	denotes	that
T21729	2438-2448	VB	denotes	suggesting
T21680	2136-2144	NN	denotes	residues
T21679	2130-2135	DT	denotes	these
T21678	2121-2129	VB	denotes	mutating
T21677	2119-2120	-COMMA-	denotes	,
T21676	2108-2119	RB	denotes	Furthermore
T21675	2098-2106	NN	denotes	residues
T21674	2091-2097	NN	denotes	Ser381
T21673	2087-2090	CC	denotes	and
T21672	2083-2086	CD	denotes	435
T21671	2079-2082	CC	denotes	and
T21670	2077-2078	-COMMA-	denotes	,
T21669	2070-2077	CD	denotes	195/197
T21668	2068-2069	-COMMA-	denotes	,
T21667	2062-2068	NN	denotes	Thr146
T21666	2059-2061	IN	denotes	on
T21665	2053-2058	FW	denotes	vitro
T21664	2050-2052	FW	denotes	in
T21663	2043-2049	NN	denotes	kinase
T21662	2038-2042	NN	denotes	RIP1
T21661	2026-2037	JJ	denotes	recombinant
T21660	2023-2025	IN	denotes	by
T21659	2019-2022	NN	denotes	Akt
T21658	2016-2018	IN	denotes	of
T21657	2000-2015	NN	denotes	phosphorylation
T21656	1991-1999	VB	denotes	observed
T21655	1988-1990	PRP	denotes	we
T21654	1986-1987	-COMMA-	denotes	,
T21653	1973-1986	RB	denotes	Interestingly
T21652	1963-1971	RB	denotes	together
T21651	1955-1962	NN	denotes	kinases
T21650	1951-1954	CD	denotes	two
T21649	1945-1950	DT	denotes	these
T21648	1939-1944	VB	denotes	bring
T21647	1934-1938	WDT	denotes	that
T21646	1926-1933	NN	denotes	factors
T21645	1914-1925	NN	denotes	scaffolding
T21644	1911-1913	CC	denotes	or
T21643	1907-1910	NN	denotes	Akt
T21642	1905-1906	-COMMA-	denotes	,
T21641	1901-1905	NN	denotes	PDK1
T21640	1891-1900	VB	denotes	targeting
T21639	1884-1890	NN	denotes	kinase
T21638	1879-1883	NN	denotes	RIP1
T21637	1874-1878	IN	denotes	from
T21636	1866-1873	VB	denotes	results
T21635	1859-1865	NN	denotes	Thr308
T21634	1856-1858	IN	denotes	in
T21633	1847-1855	NN	denotes	increase
T21632	1843-1846	DT	denotes	the
T21631	1838-1842	IN	denotes	that
T21630	1835-1837	VB	denotes	is
T21629	1823-1834	NN	denotes	possibility
T21628	1815-1822	DT	denotes	Another
T21627	1808-1813	NN	denotes	cells
T21626	1803-1807	NN	denotes	L929
T21625	1800-1802	IN	denotes	in
T21624	1788-1799	NN	denotes	necroptosis
T21623	1785-1787	IN	denotes	of
T21622	1774-1784	NN	denotes	activation
T21621	1771-1773	CC	denotes	or
T21620	1755-1770	NN	denotes	phosphorylation
T21619	1748-1754	NN	denotes	Thr308
T21618	1745-1747	IN	denotes	on
T21617	1743-1744	-COMMA-	denotes	,
T21616	1739-1743	NN	denotes	acid
T21615	1731-1738	JJ	denotes	okadaic
T21614	1729-1730	-COMMA-	denotes	,
T21613	1720-1729	NN	denotes	inhibitor
T21612	1715-1719	NN	denotes	PP2A
T21611	1711-1714	DT	denotes	the
T21610	1708-1710	IN	denotes	of
T21609	1701-1707	NN	denotes	effect
T21608	1697-1700	DT	denotes	any
T21607	1689-1696	VB	denotes	observe
T21606	1685-1688	RB	denotes	not
T21605	1681-1684	VB	denotes	did
T21604	1678-1680	PRP	denotes	we
T21603	1676-1677	-COMMA-	denotes	,
T21602	1669-1676	RB	denotes	However
T21601	1666-1667	-RRB-	denotes	]
T21600	1664-1666	CD	denotes	45
T21599	1663-1664	-LRB-	denotes	[
T21598	1655-1662	NN	denotes	residue
T21597	1650-1654	DT	denotes	this
T21596	1634-1649	VB	denotes	dephosphorylate
T21595	1621-1633	RB	denotes	specifically
T21594	1618-1620	TO	denotes	to
T21593	1606-1617	VB	denotes	established
T21592	1599-1605	NN	denotes	enzyme
T21591	1594-1598	JJ	denotes	only
T21590	1590-1593	DT	denotes	the
T21589	1587-1589	VB	denotes	is
T21588	1582-1586	NN	denotes	PP2A
T21587	1580-1581	-COMMA-	denotes	,
T21586	1571-1580	NN	denotes	knowledge
T21585	1567-1570	PRP-DOLLAR-	denotes	our
T21584	1564-1566	TO	denotes	To
T21583	1556-1562	NN	denotes	Thr308
T21582	1548-1555	VB	denotes	targets
T21581	1543-1547	WDT	denotes	that
T21580	1531-1542	NN	denotes	phosphatase
T21579	1529-1530	DT	denotes	a
T21578	1520-1528	VB	denotes	inhibits
T21577	1513-1519	NN	denotes	kinase
T21576	1508-1512	NN	denotes	RIP1
T21575	1503-1507	IN	denotes	that
T21574	1500-1502	VB	denotes	is
T21573	1488-1499	NN	denotes	possibility
T21572	1484-1487	CD	denotes	One
T21571	1467-1482	NN	denotes	phosphorylation
T21570	1460-1466	NN	denotes	Thr308
T21569	1456-1459	NN	denotes	Akt
T21568	1453-1455	IN	denotes	in
T21567	1444-1452	NN	denotes	increase
T21566	1429-1443	JJ	denotes	RIP1-dependent
T21565	1425-1428	DT	denotes	the
T21564	1422-1424	IN	denotes	of
T21563	1412-1421	NN	denotes	mechanism
T21562	1408-1411	DT	denotes	the
T21561	1405-1407	VB	denotes	is
T21560	1400-1404	WP	denotes	what
T21559	1398-1399	-COMMA-	denotes	,
T21558	1393-1398	RB	denotes	First
T21557	1380-1391	NN	denotes	necroptosis
T21556	1373-1379	IN	denotes	during
T21555	1369-1372	NN	denotes	Akt
T21554	1366-1368	IN	denotes	of
T21553	1355-1365	NN	denotes	regulation
T21552	1346-1354	JJ	denotes	specific
T21551	1342-1345	DT	denotes	the
T21550	1339-1341	TO	denotes	to
T21549	1330-1338	JJ	denotes	relevant
T21548	1320-1329	NN	denotes	questions
T21547	1308-1319	JJ	denotes	mechanistic
T21546	1298-1307	JJ	denotes	important
T21545	1293-1297	DT	denotes	some
T21544	1287-1292	VB	denotes	raise
T21543	1279-1286	NN	denotes	results
T21542	1275-1278	PRP-DOLLAR-	denotes	Our
T21541	1268-1273	NN	denotes	death
T21540	1263-1267	NN	denotes	cell
T21539	1260-1262	IN	denotes	of
T21538	1255-1259	NN	denotes	form
T21537	1250-1254	DT	denotes	this
T21536	1247-1249	IN	denotes	of
T21535	1238-1246	NN	denotes	mediator
T21534	1234-1237	JJ	denotes	new
T21533	1232-1233	DT	denotes	a
T21532	1220-1231	VB	denotes	identifying
T21531	1212-1219	RB	denotes	thereby
T21530	1210-1211	-COMMA-	denotes	,
T21529	1199-1210	NN	denotes	necroptosis
T21528	1196-1198	TO	denotes	to
T21527	1184-1195	VB	denotes	contributes
T21526	1177-1183	NN	denotes	mTORC1
T21525	1174-1176	IN	denotes	of
T21524	1163-1173	RB	denotes	downstream
T21523	1155-1162	NN	denotes	pathway
T21522	1146-1154	NN	denotes	effector
T21521	1142-1145	NN	denotes	Akt
T21520	1138-1141	DT	denotes	the
T21519	1133-1137	IN	denotes	that
T21518	1126-1132	VB	denotes	reveal
T21517	1121-1125	NN	denotes	data
T21516	1117-1120	PRP-DOLLAR-	denotes	our
T21515	1113-1116	CC	denotes	and
T21514	1107-1112	NN	denotes	cells
T21513	1102-1106	NN	denotes	L929
T21512	1099-1101	IN	denotes	in
T21511	1088-1098	NN	denotes	substrates
T21510	1082-1087	VB	denotes	known
T21509	1079-1081	IN	denotes	of
T21508	1072-1078	NN	denotes	number
T21507	1070-1071	DT	denotes	a
T21506	1062-1069	IN	denotes	towards
T21505	1053-1061	NN	denotes	activity
T21504	1049-1052	PRP-DOLLAR-	denotes	its
T21503	1040-1048	VB	denotes	increase
T21502	1037-1039	TO	denotes	to
T21501	1026-1036	JJ	denotes	sufficient
T21500	1023-1025	VB	denotes	is
T21499	1019-1022	NN	denotes	Akt
T21498	1016-1018	IN	denotes	of
T21497	1009-1015	NN	denotes	Thr308
T21496	1006-1008	IN	denotes	of
T21495	990-1005	NN	denotes	phosphorylation
T21494	978-989	JJ	denotes	Necroptotic
T21493	967-976	NN	denotes	signaling
T21492	955-966	JJ	denotes	necroptotic
T21491	951-954	IN	denotes	for
T21990	4010-4017	NN	denotes	targets
T21989	4006-4009	NN	denotes	Akt
T21988	3994-4005	VB	denotes	established
T21987	3989-3993	RB	denotes	well
T21986	3986-3988	IN	denotes	of
T21985	3979-3985	NN	denotes	number
T21984	3977-3978	DT	denotes	a
T21983	3968-3976	VB	denotes	involves
T21982	3960-3967	RB	denotes	clearly
T21981	3949-3959	NN	denotes	regulation
T21980	3944-3948	DT	denotes	this
T21979	3942-3943	-COMMA-	denotes	,
T21978	3937-3942	VB	denotes	exist
T21977	3933-3936	NN	denotes	Akt
T21976	3930-3932	IN	denotes	of
T21975	3922-3929	NN	denotes	targets
T21974	3901-3921	JJ	denotes	necroptosis-specific
T21973	3896-3900	IN	denotes	that
T21972	3887-3895	JJ	denotes	possible
T21971	3884-3886	VB	denotes	is
T21970	3881-3883	PRP	denotes	it
T21969	3875-3880	IN	denotes	while
T21968	3873-3874	-COMMA-	denotes	,
T21967	3862-3873	RB	denotes	Importantly
T21966	3854-3860	NN	denotes	kinase
T21965	3849-3853	NN	denotes	RIP1
T21964	3846-3848	IN	denotes	by
T21963	3842-3845	NN	denotes	Akt
T21962	3839-3841	IN	denotes	of
T21961	3828-3838	NN	denotes	regulation
T21960	3810-3827	JJ	denotes	necrosis-specific
T21959	3807-3809	IN	denotes	of
T21958	3802-3806	NN	denotes	mode
T21957	3798-3801	JJ	denotes	new
T21956	3796-3797	DT	denotes	a
T21955	3783-3795	VB	denotes	demonstrates
T21954	3778-3782	NN	denotes	data
T21953	3774-3777	PRP-DOLLAR-	denotes	Our
T21952	3771-3772	-RRB-	denotes	]
T21951	3769-3771	CD	denotes	47
T21950	3768-3769	-LRB-	denotes	[
T21949	3766-3767	-COMMA-	denotes	,
T21948	3765-3766	-RRB-	denotes	]
T21947	3763-3765	CD	denotes	45
T21946	3762-3763	-LRB-	denotes	[
T21945	3757-3761	RB	denotes	well
T21490	942-950	VB	denotes	required
T21489	939-941	VB	denotes	is
T21488	934-938	NN	denotes	turn
T21487	931-933	IN	denotes	in
T21486	925-930	WDT	denotes	which
T21485	923-924	-COMMA-	denotes	,
T21484	920-923	NN	denotes	Akt
T21483	917-919	IN	denotes	of
T21482	901-916	NN	denotes	phosphorylation
T21481	894-900	NN	denotes	Thr308
T21480	890-893	IN	denotes	for
T21479	881-889	VB	denotes	required
T21478	878-880	VB	denotes	is
T21477	872-877	NN	denotes	input
T21476	855-871	JJ	denotes	kinase-dependent
T21475	850-854	NN	denotes	RIP1
T21474	848-849	-COMMA-	denotes	,
T21473	842-848	JJ	denotes	second
T21472	840-841	DT	denotes	A
T21471	829-838	NN	denotes	synthesis
T21470	824-828	NN	denotes	TNFα
T21469	820-823	CC	denotes	and
T21468	816-819	NN	denotes	JNK
T21467	813-815	IN	denotes	of
T21466	802-812	NN	denotes	activation
T21686	2169-2171	TO	denotes	to
T21685	2163-2168	VB	denotes	leads
T21728	2436-2437	-COMMA-	denotes	,
T21727	2429-2436	NN	denotes	peptide
T21726	2422-2428	NN	denotes	Thr435
T21725	2414-2421	IN	denotes	against
T21724	2407-2413	VB	denotes	raised
T21723	2398-2406	NN	denotes	antibody
T21722	2381-2397	JJ	denotes	phospho-specific
T21721	2379-2380	DT	denotes	a
T21720	2374-2378	IN	denotes	with
T21719	2365-2373	NN	denotes	blotting
T21718	2357-2364	JJ	denotes	western
T21717	2354-2356	CC	denotes	or
T21716	2341-2353	NN	denotes	spectrometry
T21715	2336-2340	NN	denotes	mass
T21714	2329-2335	CC	denotes	either
T21713	2323-2328	VB	denotes	using
T21712	2317-2322	NN	denotes	cells
T21711	2312-2316	NN	denotes	L929
T21710	2309-2311	IN	denotes	in
T21709	2305-2308	NN	denotes	Akt
T21708	2294-2304	JJ	denotes	endogenous
T21707	2291-2293	IN	denotes	on
T21706	2282-2290	NN	denotes	residues
T21705	2276-2281	DT	denotes	these
T21704	2273-2275	IN	denotes	of
T21703	2257-2272	NN	denotes	phosphorylation
T21702	2249-2256	VB	denotes	confirm
T21701	2246-2248	TO	denotes	to
T21700	2241-2245	JJ	denotes	able
T21699	2237-2240	RB	denotes	not
T21698	2232-2236	VB	denotes	were
T21697	2229-2231	PRP	denotes	we
T21696	2227-2228	-COMMA-	denotes	,
T21695	2220-2227	RB	denotes	However
T21694	2207-2218	NN	denotes	necroptosis
T21693	2199-2206	VB	denotes	promote
T21692	2196-2198	TO	denotes	to
T21691	2188-2195	NN	denotes	ability
T21690	2184-2187	PRP-DOLLAR-	denotes	its
T21689	2181-2183	IN	denotes	of
T21688	2176-2180	NN	denotes	loss
T21687	2172-2175	DT	denotes	the
T21684	2155-2162	NN	denotes	Myr-Akt
T21683	2152-2154	IN	denotes	in
T21682	2148-2151	NN	denotes	Ala
T21681	2145-2147	TO	denotes	to
T21464	789-791	CC	denotes	or
T21463	777-788	NN	denotes	necroptosis
T21462	774-776	IN	denotes	of
T21461	764-773	NN	denotes	induction
T21460	760-763	DT	denotes	the
T21459	756-759	IN	denotes	for
T21458	745-755	JJ	denotes	sufficient
T21457	741-744	RB	denotes	not
T21456	738-740	VB	denotes	is
T21455	730-737	NN	denotes	Myr-Akt
T21454	727-729	IN	denotes	of
T21453	716-726	NN	denotes	expression
T21452	714-715	-COMMA-	denotes	,
T21451	710-714	NN	denotes	time
T21450	705-709	JJ	denotes	same
T21449	701-704	DT	denotes	the
T21448	698-700	IN	denotes	At
T21447	685-696	NN	denotes	requirement
T21446	680-684	DT	denotes	this
T21445	670-679	VB	denotes	overcomes
T21444	662-669	NN	denotes	Myr-Akt
T21443	644-661	JJ	denotes	membrane-targeted
T21442	637-643	JJ	denotes	active
T21441	622-636	RB	denotes	constitutively
T21440	619-621	IN	denotes	of
T21439	608-618	NNP	denotes	Expression
T21438	603-607	NNP	denotes	Akt.
T21437	600-602	IN	denotes	of
T21436	587-599	NN	denotes	localization
T21435	578-586	NN	denotes	membrane
T21434	571-577	NN	denotes	plasma
T21433	567-570	DT	denotes	the
T21432	564-566	TO	denotes	to
T21431	558-563	VB	denotes	leads
T21430	556-557	-COMMA-	denotes	,
T21429	549-556	NN	denotes	factors
T21428	542-548	NN	denotes	growth
T21427	539-541	IN	denotes	by
T21426	531-538	VB	denotes	induced
T21425	528-530	VB	denotes	is
T21424	522-527	WDT	denotes	which
T21423	520-521	-COMMA-	denotes	,
T21422	515-520	NN	denotes	input
T21421	509-514	JJ	denotes	first
T21420	505-508	DT	denotes	The
T21419	496-503	NN	denotes	signals
T21418	487-495	JJ	denotes	distinct
T21417	483-486	CD	denotes	two
T21416	474-482	VB	denotes	requires
T21415	470-473	NN	denotes	Akt
T21414	467-469	IN	denotes	of
T21413	451-466	NN	denotes	phosphorylation
T21412	449-450	-COMMA-	denotes	,
T21411	444-449	NN	denotes	model
T21410	440-443	PRP-DOLLAR-	denotes	our
T21409	437-439	TO	denotes	to
T21408	427-436	VB	denotes	According
T21407	420-425	NN	denotes	death
T21406	415-419	NN	denotes	cell
T21405	406-414	JJ	denotes	eventual
T21404	402-405	CC	denotes	and
T21403	392-401	NN	denotes	synthesis
T21402	387-391	NN	denotes	TNFα
T21401	377-386	JJ	denotes	autocrine
T21400	375-376	-COMMA-	denotes	,
T21399	365-375	NN	denotes	activation
T21398	361-364	NN	denotes	JNK
T21397	351-360	VB	denotes	including
T21396	349-350	-COMMA-	denotes	,
T21395	344-349	NN	denotes	cells
T21394	339-343	NN	denotes	L929
T21393	336-338	IN	denotes	in
T21392	324-335	NN	denotes	necroptosis
T21391	317-323	IN	denotes	during
T21390	310-316	NN	denotes	events
T21389	300-309	NN	denotes	execution
T21388	296-299	CC	denotes	and
T21387	286-295	NN	denotes	signaling
T21386	275-285	JJ	denotes	downstream
T21385	272-274	TO	denotes	to
T21384	265-271	NN	denotes	kinase
T21383	260-264	NN	denotes	RIP1
T21382	249-259	VB	denotes	connecting
T21381	244-248	NN	denotes	link
T21380	242-243	DT	denotes	a
T21379	233-241	VB	denotes	provides
T21378	228-232	DT	denotes	This
T21377	220-226	NN	denotes	Thr308
T21376	217-219	IN	denotes	on
T21375	201-216	NN	denotes	phosphorylation
T21374	197-200	NN	denotes	Akt
T21373	194-196	IN	denotes	in
T21372	185-193	NN	denotes	increase
T21371	175-184	JJ	denotes	selective
T21370	173-174	DT	denotes	a
T21369	163-172	VB	denotes	promoting
T21368	155-162	IN	denotes	through
T21367	146-154	NN	denotes	activity
T21366	142-145	PRP-DOLLAR-	denotes	its
T21365	135-141	VB	denotes	exerts
T21364	129-134	WDT	denotes	which
T21363	127-128	-COMMA-	denotes	,
T21362	121-127	NN	denotes	kinase
T21361	116-120	NN	denotes	RIP1
T21360	111-115	IN	denotes	from
T21359	100-110	RB	denotes	downstream
T21358	90-99	NN	denotes	signaling
T21357	86-89	DT	denotes	the
T21356	83-85	IN	denotes	in
T21355	75-82	VB	denotes	engaged
T21354	62-74	RB	denotes	specifically
T21353	59-61	VB	denotes	is
T21352	52-58	NN	denotes	kinase
T21351	48-51	NN	denotes	Akt
T21350	43-47	IN	denotes	that
T21349	35-42	VB	denotes	suggest
T21348	27-34	NN	denotes	results
T21347	23-26	PRP-DOLLAR-	denotes	our
T21346	21-22	-COMMA-	denotes	,
T21345	11-21	RB	denotes	Altogether
T21465	792-801	JJ	denotes	efficient
R15317	T22651	T22650	arg1Of	death,patient
R13990	T21348	T21347	arg1Of	results,our
R13991	T21348	T21349	arg1Of	results,suggest
R13992	T21349	T21345	arg1Of	suggest,Altogether
R13993	T21349	T21346	arg1Of	suggest,","
R13994	T21352	T21351	arg1Of	kinase,Akt
R13995	T21352	T21353	arg1Of	kinase,is
R13996	T21352	T21355	arg2Of	kinase,engaged
R13997	T21355	T21349	arg2Of	engaged,suggest
R13998	T21355	T21350	arg1Of	engaged,that
R13999	T21355	T21353	arg2Of	engaged,is
R14000	T21355	T21354	arg1Of	engaged,specifically
R14001	T21355	T21356	arg1Of	engaged,in
R14002	T21355	T21360	arg1Of	engaged,from
R14003	T21358	T21356	arg2Of	signaling,in
R14004	T21358	T21357	arg1Of	signaling,the
R14005	T21360	T21359	arg1Of	from,downstream
R14006	T21362	T21360	arg2Of	kinase,from
R14007	T21362	T21361	arg1Of	kinase,RIP1
R14008	T21362	T21363	arg1Of	kinase,","
R14009	T21362	T21364	arg1Of	kinase,which
R14010	T21362	T21365	arg1Of	kinase,exerts
R14011	T21365	T21368	arg1Of	exerts,through
R14012	T21367	T21365	arg2Of	activity,exerts
R14013	T21367	T21366	arg1Of	activity,its
R14014	T21369	T21368	arg2Of	promoting,through
R14015	T21372	T21369	arg2Of	increase,promoting
R14016	T21372	T21370	arg1Of	increase,a
R14017	T21372	T21371	arg1Of	increase,selective
R14018	T21372	T21373	arg1Of	increase,in
R14019	T21372	T21376	arg1Of	increase,on
R14020	T21375	T21373	arg2Of	phosphorylation,in
R14021	T21375	T21374	arg1Of	phosphorylation,Akt
R14022	T21377	T21376	arg2Of	Thr308,on
R14023	T21378	T21379	arg1Of	This,provides
R14024	T21381	T21379	arg2Of	link,provides
R14025	T21381	T21380	arg1Of	link,a
R14026	T21381	T21382	arg1Of	link,connecting
R14027	T21382	T21385	arg1Of	connecting,to
R14028	T21382	T21391	arg1Of	connecting,during
R14029	T21384	T21382	arg2Of	kinase,connecting
R14030	T21384	T21383	arg1Of	kinase,RIP1
R14031	T21387	T21388	arg1Of	signaling,and
R14032	T21389	T21388	arg2Of	execution,and
R14033	T21390	T21385	arg2Of	events,to
R14034	T21390	T21386	arg1Of	events,downstream
R14035	T21390	T21387	arg1Of	events,signaling
R14036	T21390	T21389	arg1Of	events,execution
R14037	T21392	T21391	arg2Of	necroptosis,during
R14038	T21392	T21393	arg1Of	necroptosis,in
R14039	T21395	T21393	arg2Of	cells,in
R14040	T21395	T21394	arg1Of	cells,L929
R14041	T21395	T21396	arg1Of	cells,","
R14042	T21395	T21397	arg1Of	cells,including
R14043	T21399	T21398	arg1Of	activation,JNK
R14044	T21399	T21400	arg1Of	activation,","
R14045	T21400	T21404	arg1Of	",",and
R14046	T21403	T21400	arg2Of	synthesis,","
R14047	T21403	T21401	arg1Of	synthesis,autocrine
R14048	T21403	T21402	arg1Of	synthesis,TNFα
R14049	T21404	T21397	arg2Of	and,including
R14050	T21407	T21404	arg2Of	death,and
R14051	T21407	T21405	arg1Of	death,eventual
R14052	T21407	T21406	arg1Of	death,cell
R14053	T21409	T21408	arg2Of	to,According
R14054	T21411	T21409	arg2Of	model,to
R14055	T21411	T21410	arg1Of	model,our
R14056	T21413	T21414	arg1Of	phosphorylation,of
R14057	T21413	T21416	arg1Of	phosphorylation,requires
R14058	T21415	T21414	arg2Of	Akt,of
R14059	T21416	T21408	arg1Of	requires,According
R14060	T21416	T21412	arg1Of	requires,","
R14061	T21419	T21416	arg2Of	signals,requires
R14062	T21419	T21417	arg1Of	signals,two
R14063	T21419	T21418	arg1Of	signals,distinct
R14064	T21422	T21420	arg1Of	input,The
R14065	T21422	T21421	arg1Of	input,first
R14066	T21422	T21423	arg1Of	input,","
R14067	T21422	T21424	arg1Of	input,which
R14068	T21422	T21425	arg1Of	input,is
R14069	T21422	T21426	arg2Of	input,induced
R14070	T21422	T21431	arg1Of	input,leads
R14071	T21422	T21445	arg1Of	input,overcomes
R14072	T21426	T21425	arg2Of	induced,is
R14073	T21426	T21430	arg1Of	induced,","
R14074	T21429	T21426	arg1Of	factors,induced
R14075	T21429	T21427	arg2Of	factors,by
R14076	T21429	T21428	arg1Of	factors,growth
R14077	T21431	T21430	arg2Of	leads,","
R14078	T21431	T21432	arg1Of	leads,to
R14079	T21436	T21432	arg2Of	localization,to
R14080	T21436	T21433	arg1Of	localization,the
R14081	T21436	T21434	arg1Of	localization,plasma
R14082	T21436	T21435	arg1Of	localization,membrane
R14083	T21436	T21437	arg1Of	localization,of
R14084	T21439	T21437	arg2Of	Expression,of
R14085	T21439	T21438	arg1Of	Expression,Akt.
R14086	T21439	T21440	arg1Of	Expression,of
R14087	T21444	T21440	arg2Of	Myr-Akt,of
R14088	T21444	T21441	arg1Of	Myr-Akt,constitutively
R14089	T21444	T21442	arg1Of	Myr-Akt,active
R14090	T21444	T21443	arg1Of	Myr-Akt,membrane-targeted
R14091	T21447	T21445	arg2Of	requirement,overcomes
R14092	T21447	T21446	arg1Of	requirement,this
R14093	T21451	T21448	arg2Of	time,At
R14094	T21451	T21449	arg1Of	time,the
R14095	T21451	T21450	arg1Of	time,same
R14096	T21453	T21454	arg1Of	expression,of
R14097	T21453	T21456	arg1Of	expression,is
R14098	T21453	T21458	arg1Of	expression,sufficient
R14099	T21455	T21454	arg2Of	Myr-Akt,of
R14100	T21456	T21448	arg1Of	is,At
R14101	T21456	T21452	arg1Of	is,","
R14102	T21456	T21457	arg1Of	is,not
R14103	T21458	T21456	arg2Of	sufficient,is
R14104	T21458	T21459	arg1Of	sufficient,for
R14105	T21461	T21459	arg2Of	induction,for
R14106	T21461	T21460	arg1Of	induction,the
R14107	T21461	T21462	arg1Of	induction,of
R14108	T21463	T21464	arg1Of	necroptosis,or
R14109	T21465	T21464	arg2Of	efficient,or
R14110	T21466	T21462	arg2Of	activation,of
R14111	T21466	T21463	arg1Of	activation,necroptosis
R14112	T21466	T21465	arg1Of	activation,efficient
R14113	T21466	T21467	arg1Of	activation,of
R14114	T21468	T21469	arg1Of	JNK,and
R14115	T21469	T21467	arg2Of	and,of
R14116	T21471	T21469	arg2Of	synthesis,and
R14117	T21471	T21470	arg1Of	synthesis,TNFα
R14118	T21473	T21474	arg1Of	second,","
R14119	T21476	T21474	arg2Of	kinase-dependent,","
R14120	T21476	T21475	arg1Of	kinase-dependent,RIP1
R14121	T21477	T21472	arg1Of	input,A
R14122	T21477	T21473	arg1Of	input,second
R14123	T21477	T21476	arg1Of	input,kinase-dependent
R14124	T21477	T21478	arg1Of	input,is
R14125	T21477	T21479	arg2Of	input,required
R14126	T21479	T21478	arg2Of	required,is
R14127	T21479	T21480	arg1Of	required,for
R14128	T21482	T21480	arg2Of	phosphorylation,for
R14129	T21482	T21481	arg1Of	phosphorylation,Thr308
R14130	T21482	T21483	arg1Of	phosphorylation,of
R14131	T21484	T21483	arg2Of	Akt,of
R14132	T21484	T21485	arg1Of	Akt,","
R14133	T21484	T21486	arg1Of	Akt,which
R14134	T21484	T21489	arg1Of	Akt,is
R14135	T21484	T21490	arg2Of	Akt,required
R14136	T21488	T21487	arg2Of	turn,in
R14137	T21490	T21487	arg1Of	required,in
R14138	T21490	T21489	arg2Of	required,is
R14139	T21490	T21491	arg1Of	required,for
R14140	T21493	T21491	arg2Of	signaling,for
R14141	T21493	T21492	arg1Of	signaling,necroptotic
R14142	T21495	T21494	arg1Of	phosphorylation,Necroptotic
R14143	T21495	T21496	arg1Of	phosphorylation,of
R14144	T21495	T21498	arg1Of	phosphorylation,of
R14145	T21495	T21500	arg1Of	phosphorylation,is
R14146	T21495	T21501	arg1Of	phosphorylation,sufficient
R14147	T21497	T21496	arg2Of	Thr308,of
R14148	T21499	T21498	arg2Of	Akt,of
R14149	T21500	T21515	arg1Of	is,and
R14150	T21501	T21500	arg2Of	sufficient,is
R14151	T21503	T21501	arg2Of	increase,sufficient
R14152	T21503	T21502	arg1Of	increase,to
R14153	T21503	T21506	arg1Of	increase,towards
R14154	T21505	T21503	arg2Of	activity,increase
R14155	T21505	T21504	arg1Of	activity,its
R14156	T21508	T21506	arg2Of	number,towards
R14157	T21508	T21507	arg1Of	number,a
R14158	T21508	T21509	arg1Of	number,of
R14159	T21511	T21509	arg2Of	substrates,of
R14160	T21511	T21510	arg2Of	substrates,known
R14161	T21511	T21512	arg1Of	substrates,in
R14162	T21514	T21512	arg2Of	cells,in
R14163	T21514	T21513	arg1Of	cells,L929
R14164	T21517	T21516	arg1Of	data,our
R14165	T21517	T21518	arg1Of	data,reveal
R14166	T21518	T21515	arg2Of	reveal,and
R14167	T21523	T21520	arg1Of	pathway,the
R14168	T21523	T21521	arg1Of	pathway,Akt
R14169	T21523	T21522	arg1Of	pathway,effector
R14170	T21523	T21524	arg1Of	pathway,downstream
R14171	T21523	T21527	arg1Of	pathway,contributes
R14172	T21524	T21525	arg1Of	downstream,of
R14173	T21526	T21525	arg2Of	mTORC1,of
R14174	T21527	T21518	arg2Of	contributes,reveal
R14175	T21527	T21519	arg1Of	contributes,that
R14176	T21527	T21528	arg1Of	contributes,to
R14177	T21527	T21530	arg1Of	contributes,","
R14178	T21527	T21532	modOf	contributes,identifying
R14179	T21529	T21528	arg2Of	necroptosis,to
R14180	T21532	T21531	arg1Of	identifying,thereby
R14181	T21535	T21532	arg2Of	mediator,identifying
R14182	T21535	T21533	arg1Of	mediator,a
R14183	T21535	T21534	arg1Of	mediator,new
R14184	T21535	T21536	arg1Of	mediator,of
R14185	T21538	T21536	arg2Of	form,of
R14186	T21538	T21537	arg1Of	form,this
R14187	T21538	T21539	arg1Of	form,of
R14188	T21541	T21539	arg2Of	death,of
R14189	T21541	T21540	arg1Of	death,cell
R14190	T21543	T21542	arg1Of	results,Our
R14191	T21543	T21544	arg1Of	results,raise
R14192	T21548	T21544	arg2Of	questions,raise
R14193	T21548	T21545	arg1Of	questions,some
R14194	T21548	T21546	arg1Of	questions,important
R14195	T21548	T21547	arg1Of	questions,mechanistic
R14196	T21548	T21549	arg1Of	questions,relevant
R14197	T21549	T21550	arg1Of	relevant,to
R14198	T21553	T21550	arg2Of	regulation,to
R14199	T21553	T21551	arg1Of	regulation,the
R14200	T21553	T21552	arg1Of	regulation,specific
R14201	T21553	T21554	arg1Of	regulation,of
R14202	T21553	T21556	arg1Of	regulation,during
R14203	T21555	T21554	arg2Of	Akt,of
R14204	T21557	T21556	arg2Of	necroptosis,during
R14205	T21560	T21561	arg1Of	what,is
R14206	T21561	T21558	arg1Of	is,First
R14207	T21561	T21559	arg1Of	is,","
R14208	T21563	T21561	arg2Of	mechanism,is
R14209	T21563	T21562	arg1Of	mechanism,the
R14210	T21563	T21564	arg1Of	mechanism,of
R14211	T21567	T21564	arg2Of	increase,of
R14212	T21567	T21565	arg1Of	increase,the
R14213	T21567	T21566	arg1Of	increase,RIP1-dependent
R14214	T21567	T21568	arg1Of	increase,in
R14215	T21571	T21568	arg2Of	phosphorylation,in
R14216	T21571	T21569	arg1Of	phosphorylation,Akt
R14217	T21571	T21570	arg1Of	phosphorylation,Thr308
R14218	T21573	T21572	arg1Of	possibility,One
R14219	T21573	T21574	arg1Of	possibility,is
R14220	T21577	T21576	arg1Of	kinase,RIP1
R14221	T21577	T21578	arg1Of	kinase,inhibits
R14222	T21578	T21574	arg2Of	inhibits,is
R14223	T21578	T21575	arg1Of	inhibits,that
R14224	T21580	T21578	arg2Of	phosphatase,inhibits
R14225	T21580	T21579	arg1Of	phosphatase,a
R14226	T21580	T21581	arg1Of	phosphatase,that
R14227	T21580	T21582	arg1Of	phosphatase,targets
R14228	T21583	T21582	arg2Of	Thr308,targets
R14229	T21586	T21584	arg2Of	knowledge,To
R14230	T21586	T21585	arg1Of	knowledge,our
R14231	T21588	T21589	arg1Of	PP2A,is
R14232	T21589	T21584	arg1Of	is,To
R14233	T21589	T21587	arg1Of	is,","
R14234	T21592	T21589	arg2Of	enzyme,is
R14235	T21592	T21590	arg1Of	enzyme,the
R14236	T21592	T21591	arg1Of	enzyme,only
R14237	T21592	T21593	arg2Of	enzyme,established
R14238	T21593	T21594	modOf	established,to
R14239	T21596	T21594	arg1Of	dephosphorylate,to
R14240	T21596	T21595	arg1Of	dephosphorylate,specifically
R14241	T21596	T21599	arg1Of	dephosphorylate,[
R14242	T21598	T21596	arg2Of	residue,dephosphorylate
R14243	T21598	T21597	arg1Of	residue,this
R14244	T21600	T21599	arg2Of	45,[
R14245	T21601	T21599	arg3Of	],[
R14246	T21604	T21605	arg1Of	we,did
R14247	T21604	T21607	arg1Of	we,observe
R14248	T21607	T21602	arg1Of	observe,However
R14249	T21607	T21603	arg1Of	observe,","
R14250	T21607	T21605	arg2Of	observe,did
R14251	T21607	T21606	arg1Of	observe,not
R14252	T21609	T21607	arg2Of	effect,observe
R14253	T21609	T21608	arg1Of	effect,any
R14254	T21609	T21610	arg1Of	effect,of
R14255	T21609	T21617	arg1Of	effect,","
R14256	T21609	T21618	arg1Of	effect,on
R14257	T21613	T21610	arg2Of	inhibitor,of
R14258	T21613	T21611	arg1Of	inhibitor,the
R14259	T21613	T21612	arg1Of	inhibitor,PP2A
R14260	T21613	T21614	arg1Of	inhibitor,","
R14261	T21616	T21614	arg2Of	acid,","
R14262	T21616	T21615	arg1Of	acid,okadaic
R14263	T21620	T21619	arg1Of	phosphorylation,Thr308
R14264	T21620	T21621	arg1Of	phosphorylation,or
R14265	T21621	T21618	arg2Of	or,on
R14266	T21621	T21625	arg1Of	or,in
R14267	T21622	T21621	arg2Of	activation,or
R14268	T21622	T21623	arg1Of	activation,of
R14269	T21624	T21623	arg2Of	necroptosis,of
R14270	T21627	T21625	arg2Of	cells,in
R14271	T21627	T21626	arg1Of	cells,L929
R14272	T21629	T21628	arg1Of	possibility,Another
R14273	T21629	T21630	arg1Of	possibility,is
R14274	T21633	T21632	arg1Of	increase,the
R14275	T21633	T21634	arg1Of	increase,in
R14276	T21633	T21636	arg1Of	increase,results
R14277	T21635	T21634	arg2Of	Thr308,in
R14278	T21636	T21630	arg2Of	results,is
R14279	T21636	T21631	arg1Of	results,that
R14280	T21636	T21637	arg1Of	results,from
R14281	T21639	T21637	arg2Of	kinase,from
R14282	T21639	T21638	arg1Of	kinase,RIP1
R14283	T21639	T21640	arg1Of	kinase,targeting
R14284	T21641	T21642	arg1Of	PDK1,","
R14285	T21642	T21644	arg1Of	",",or
R14286	T21643	T21642	arg2Of	Akt,","
R14287	T21645	T21644	arg2Of	scaffolding,or
R14288	T21646	T21640	arg2Of	factors,targeting
R14289	T21646	T21641	arg1Of	factors,PDK1
R14290	T21646	T21643	arg1Of	factors,Akt
R14291	T21646	T21645	arg1Of	factors,scaffolding
R14292	T21646	T21647	arg1Of	factors,that
R14293	T21646	T21648	arg1Of	factors,bring
R14294	T21651	T21648	arg2Of	kinases,bring
R14295	T21651	T21649	arg1Of	kinases,these
R14296	T21651	T21650	arg1Of	kinases,two
R14297	T21651	T21652	arg1Of	kinases,together
R14298	T21655	T21656	arg1Of	we,observed
R14299	T21656	T21653	arg1Of	observed,Interestingly
R14300	T21656	T21654	arg1Of	observed,","
R14301	T21657	T21656	arg2Of	phosphorylation,observed
R14302	T21657	T21658	arg1Of	phosphorylation,of
R14303	T21657	T21660	arg1Of	phosphorylation,by
R14304	T21659	T21658	arg2Of	Akt,of
R14305	T21663	T21661	arg1Of	kinase,recombinant
R14306	T21663	T21662	arg1Of	kinase,RIP1
R14307	T21663	T21665	arg1Of	kinase,vitro
R14308	T21663	T21666	arg1Of	kinase,on
R14309	T21663	T21671	arg1Of	kinase,and
R14310	T21665	T21664	arg1Of	vitro,in
R14311	T21667	T21666	arg2Of	Thr146,on
R14312	T21667	T21668	arg1Of	Thr146,","
R14313	T21669	T21668	arg2Of	195/197,","
R14314	T21671	T21660	arg2Of	and,by
R14315	T21671	T21670	arg1Of	and,","
R14316	T21672	T21673	arg1Of	435,and
R14317	T21673	T21671	arg2Of	and,and
R14318	T21675	T21673	arg2Of	residues,and
R14319	T21675	T21674	arg1Of	residues,Ser381
R14320	T21678	T21681	arg1Of	mutating,to
R14321	T21678	T21685	arg1Of	mutating,leads
R14322	T21680	T21678	arg2Of	residues,mutating
R14323	T21680	T21679	arg1Of	residues,these
R14324	T21682	T21681	arg2Of	Ala,to
R14325	T21682	T21683	arg1Of	Ala,in
R14326	T21684	T21683	arg2Of	Myr-Akt,in
R14327	T21685	T21676	arg1Of	leads,Furthermore
R14328	T21685	T21677	arg1Of	leads,","
R14329	T21685	T21686	arg1Of	leads,to
R14330	T21688	T21686	arg2Of	loss,to
R14331	T21688	T21687	arg1Of	loss,the
R14332	T21688	T21689	arg1Of	loss,of
R14333	T21691	T21689	arg2Of	ability,of
R14334	T21691	T21690	arg1Of	ability,its
R14335	T21691	T21692	modOf	ability,to
R14336	T21693	T21692	arg1Of	promote,to
R14337	T21694	T21693	arg2Of	necroptosis,promote
R14338	T21697	T21698	arg1Of	we,were
R14339	T21697	T21700	arg1Of	we,able
R14340	T21697	T21702	arg1Of	we,confirm
R14341	T21698	T21695	arg1Of	were,However
R14342	T21698	T21696	arg1Of	were,","
R14343	T21698	T21699	arg1Of	were,not
R14344	T21698	T21728	arg1Of	were,","
R14345	T21698	T21729	modOf	were,suggesting
R14346	T21700	T21698	arg2Of	able,were
R14347	T21702	T21700	arg2Of	confirm,able
R14348	T21702	T21701	arg1Of	confirm,to
R14349	T21703	T21702	arg2Of	phosphorylation,confirm
R14350	T21703	T21704	arg1Of	phosphorylation,of
R14351	T21703	T21707	arg1Of	phosphorylation,on
R14352	T21706	T21704	arg2Of	residues,of
R14353	T21706	T21705	arg1Of	residues,these
R14354	T21709	T21707	arg2Of	Akt,on
R14355	T21709	T21708	arg1Of	Akt,endogenous
R14356	T21709	T21710	arg1Of	Akt,in
R14357	T21709	T21713	arg1Of	Akt,using
R14358	T21712	T21710	arg2Of	cells,in
R14359	T21712	T21711	arg1Of	cells,L929
R14360	T21716	T21715	arg1Of	spectrometry,mass
R14361	T21716	T21717	arg1Of	spectrometry,or
R14362	T21717	T21713	arg2Of	or,using
R14363	T21717	T21714	arg1Of	or,either
R14364	T21717	T21720	arg1Of	or,with
R14365	T21719	T21717	arg2Of	blotting,or
R14366	T21719	T21718	arg1Of	blotting,western
R14367	T21723	T21720	arg2Of	antibody,with
R14368	T21723	T21721	arg1Of	antibody,a
R14369	T21723	T21722	arg1Of	antibody,phospho-specific
R14370	T21723	T21724	arg2Of	antibody,raised
R14371	T21724	T21725	arg1Of	raised,against
R14372	T21727	T21725	arg2Of	peptide,against
R14373	T21727	T21726	arg1Of	peptide,Thr435
R14374	T21732	T21731	arg1Of	phosphorylation,direct
R14375	T21732	T21733	arg1Of	phosphorylation,of
R14376	T21732	T21735	arg1Of	phosphorylation,by
R14377	T21732	T21738	arg1Of	phosphorylation,represents
R14378	T21732	T21744	arg1Of	phosphorylation,does
R14379	T21732	T21746	arg1Of	phosphorylation,reflect
R14380	T21734	T21733	arg2Of	Akt,of
R14381	T21736	T21735	arg2Of	RIP1,by
R14382	T21738	T21743	arg1Of	represents,and
R14383	T21741	T21740	arg1Of	vitro,in
R14384	T21742	T21738	arg2Of	artifact,represents
R14385	T21742	T21739	arg1Of	artifact,an
R14386	T21742	T21741	arg1Of	artifact,vitro
R14387	T21743	T21729	arg2Of	and,suggesting
R14388	T21743	T21730	arg1Of	and,that
R14389	T21743	T21737	arg1Of	and,likely
R14390	T21746	T21743	arg2Of	reflect,and
R14391	T21746	T21744	arg2Of	reflect,does
R14392	T21746	T21745	arg1Of	reflect,not
R14393	T21748	T21746	arg2Of	regulation,reflect
R14394	T21748	T21747	arg1Of	regulation,endogenous
R14395	T21751	T21752	arg1Of	what,are
R14396	T21752	T21749	arg1Of	are,Second
R14397	T21752	T21750	arg1Of	are,","
R14398	T21755	T21752	arg2Of	substrates,are
R14399	T21755	T21753	arg1Of	substrates,the
R14400	T21755	T21754	arg1Of	substrates,key
R14401	T21755	T21756	arg1Of	substrates,of
R14402	T21755	T21758	arg1Of	substrates,that
R14403	T21755	T21759	arg1Of	substrates,promote
R14404	T21757	T21756	arg2Of	Akt,of
R14405	T21761	T21760	arg1Of	death,necrotic
R14406	T21761	T21762	arg1Of	death,and
R14407	T21762	T21759	arg2Of	and,promote
R14408	T21764	T21762	arg2Of	synthesis,and
R14409	T21764	T21763	arg1Of	synthesis,TNFα
R14410	T21768	T21765	arg2Of	hand,On
R14411	T21768	T21766	arg1Of	hand,the
R14412	T21768	T21767	arg1Of	hand,one
R14413	T21771	T21770	arg1Of	data,our
R14414	T21771	T21772	arg1Of	data,suggest
R14415	T21772	T21765	arg1Of	suggest,On
R14416	T21772	T21769	arg1Of	suggest,","
R14417	T21774	T21772	arg2Of	roles,suggest
R14418	T21774	T21773	arg1Of	roles,new
R14419	T21774	T21775	arg1Of	roles,for
R14420	T21778	T21775	arg2Of	pathways,for
R14421	T21778	T21776	arg1Of	pathways,Akt
R14422	T21778	T21777	arg1Of	pathways,effector
R14423	T21778	T21779	arg2Of	pathways,mediated
R14424	T21779	T21782	arg1Of	mediated,in
R14425	T21781	T21779	arg1Of	mTORC1,mediated
R14426	T21781	T21780	arg2Of	mTORC1,by
R14427	T21784	T21782	arg2Of	control,in
R14428	T21784	T21783	arg1Of	control,necroptotic
R14429	T21788	T21785	arg2Of	hand,On
R14430	T21788	T21786	arg1Of	hand,the
R14431	T21788	T21787	arg1Of	hand,other
R14432	T21790	T21791	arg1Of	we,have
R14433	T21790	T21792	arg1Of	we,observed
R14434	T21792	T21785	arg1Of	observed,On
R14435	T21792	T21789	arg1Of	observed,","
R14436	T21792	T21791	arg2Of	observed,have
R14437	T21792	T21799	arg1Of	observed,under
R14438	T21792	T21802	arg1Of	observed,","
R14439	T21792	T21803	modOf	observed,suggesting
R14440	T21794	T21793	arg1Of	modest,only
R14441	T21795	T21792	arg2Of	changes,observed
R14442	T21795	T21794	arg1Of	changes,modest
R14443	T21795	T21796	arg1Of	changes,in
R14444	T21798	T21796	arg2Of	activity,in
R14445	T21798	T21797	arg1Of	activity,mTORC1
R14446	T21801	T21799	arg2Of	conditions,under
R14447	T21801	T21800	arg1Of	conditions,necroptotic
R14448	T21807	T21805	arg1Of	substrates,additional
R14449	T21807	T21806	arg1Of	substrates,Akt
R14450	T21807	T21808	arg1Of	substrates,are
R14451	T21807	T21809	arg1Of	substrates,likely
R14452	T21807	T21811	arg1Of	substrates,be
R14453	T21807	T21812	arg2Of	substrates,involved
R14454	T21808	T21803	arg2Of	are,suggesting
R14455	T21808	T21804	arg1Of	are,that
R14456	T21809	T21808	arg2Of	likely,are
R14457	T21812	T21809	arg2Of	involved,likely
R14458	T21812	T21810	arg1Of	involved,to
R14459	T21812	T21811	arg2Of	involved,be
R14460	T21813	T21814	arg1Of	This,warrants
R14466	T21816	T21814	arg2Of	re-evaluation,warrants
R14485	T21838	T21843	arg1Of	mechanisms,remain
R14486	T21838	T21845	arg1Of	mechanisms,be
R14487	T21838	T21846	arg2Of	mechanisms,elucidated
R14493	T21846	T21843	arg2Of	elucidated,remain
R14494	T21846	T21844	arg1Of	elucidated,to
R14495	T21846	T21845	arg2Of	elucidated,be
R14496	T21848	T21849	arg1Of	there,are
R14497	T21849	T21847	arg2Of	are,While
R14498	T21852	T21849	arg2Of	examples,are
R14499	T21852	T21850	arg1Of	examples,some
R14500	T21852	T21851	arg1Of	examples,recent
R14501	T21852	T21853	arg1Of	examples,of
R14502	T21855	T21853	arg2Of	regulation,of
R14503	T21855	T21854	arg1Of	regulation,mTORC1-dependent
R14504	T21855	T21856	arg1Of	regulation,of
R14505	T21857	T21856	arg2Of	JNK,of
R14506	T21860	T21859	arg1Of	following,e.g.
R14507	T21862	T21860	arg2Of	stress,following
R14508	T21862	T21861	arg1Of	stress,ER
R14509	T21862	T21863	arg1Of	stress,[
R14510	T21864	T21863	arg2Of	46,[
R14511	T21865	T21863	arg3Of	],[
R14512	T21869	T21867	arg1Of	mechanisms,the
R14513	T21869	T21868	arg1Of	mechanisms,exact
R14514	T21869	T21870	arg1Of	mechanisms,during
R14515	T21869	T21872	arg1Of	mechanisms,remain
R14516	T21869	T21874	arg1Of	mechanisms,be
R14517	T21869	T21875	arg2Of	mechanisms,established
R14518	T21871	T21870	arg2Of	necroptosis,during
R14519	T21872	T21847	arg1Of	remain,While
R14520	T21872	T21858	arg1Of	remain,","
R14521	T21872	T21860	arg1Of	remain,following
R14522	T21872	T21866	arg1Of	remain,","
R14523	T21875	T21872	arg2Of	established,remain
R14524	T21875	T21873	arg1Of	established,to
R14525	T21875	T21874	arg2Of	established,be
R14526	T21878	T21877	arg1Of	activation,the
R14527	T21878	T21879	arg1Of	activation,of
R14528	T21878	T21881	arg1Of	activation,by
R14529	T21878	T21883	arg1Of	activation,and
R14530	T21880	T21879	arg2Of	JNK,of
R14531	T21882	T21881	arg2Of	TNFα,by
R14532	T21883	T21876	arg2Of	and,Given
R14533	T21885	T21883	arg2Of	importance,and
R14534	T21885	T21884	arg1Of	importance,the
R14535	T21885	T21886	arg1Of	importance,of
R14536	T21889	T21886	arg2Of	control,of
R14537	T21889	T21887	arg1Of	control,mTORC1-dependent
R14538	T21889	T21888	arg1Of	control,translational
R14539	T21889	T21890	arg1Of	control,in
R14540	T21891	T21890	arg2Of	necroptosis,in
R14541	T21894	T21893	arg1Of	possibility,one
R14542	T21894	T21895	arg1Of	possibility,is
R14543	T21895	T21876	arg1Of	is,Given
R14544	T21895	T21892	arg1Of	is,","
R14545	T21897	T21898	arg1Of	mTORC1,contributes
R14546	T21897	T21905	arg1Of	mTORC1,forms
R14547	T21898	T21899	arg1Of	contributes,to
R14548	T21898	T21904	arg1Of	contributes,and
R14549	T21901	T21899	arg2Of	translation,to
R14550	T21901	T21900	arg1Of	translation,the
R14551	T21901	T21902	arg1Of	translation,of
R14552	T21903	T21902	arg2Of	TNFα,of
R14553	T21904	T21895	arg2Of	and,is
R14554	T21904	T21896	arg1Of	and,that
R14555	T21905	T21904	arg2Of	forms,and
R14556	T21910	T21905	arg2Of	loop,forms
R14557	T21910	T21906	arg1Of	loop,a
R14558	T21910	T21907	arg1Of	loop,positive
R14559	T21910	T21908	arg1Of	loop,feed
R14560	T21910	T21909	arg1Of	loop,forward
R14561	T21910	T21911	arg1Of	loop,with
R14562	T21912	T21911	arg2Of	JNK,with
R14563	T21914	T21913	arg1Of	role,Akt’s
R14564	T21914	T21915	arg1Of	role,as
R14565	T21914	T21921	arg1Of	role,is
R14566	T21914	T21923	arg2Of	role,documented
R14567	T21918	T21915	arg2Of	inhibitor,as
R14568	T21918	T21916	arg1Of	inhibitor,a
R14569	T21918	T21917	arg1Of	inhibitor,key
R14570	T21918	T21919	arg1Of	inhibitor,of
R14571	T21920	T21919	arg2Of	apoptosis,of
R14572	T21923	T21921	arg2Of	documented,is
R14573	T21923	T21922	arg1Of	documented,well
R14574	T21927	T21928	arg1Of	evidence,of
R14575	T21927	T21940	arg1Of	evidence,has
R14576	T21927	T21941	arg1Of	evidence,begun
R14577	T21927	T21943	arg1Of	evidence,emerge
R14578	T21930	T21928	arg2Of	contribution,of
R14579	T21930	T21929	arg1Of	contribution,its
R14580	T21930	T21931	arg1Of	contribution,as
R14581	T21933	T21931	arg2Of	mediator,as
R14582	T21933	T21932	arg1Of	mediator,a
R14583	T21933	T21934	arg1Of	mediator,of
R14584	T21933	T21937	arg1Of	mediator,under
R14585	T21936	T21934	arg2Of	death,of
R14586	T21936	T21935	arg1Of	death,cell
R14587	T21939	T21937	arg2Of	circumstances,under
R14588	T21939	T21938	arg1Of	circumstances,various
R14589	T21941	T21923	arg3Of	begun,documented
R14590	T21941	T21924	arg1Of	begun,","
R14591	T21941	T21925	arg1Of	begun,however
R14592	T21941	T21926	arg1Of	begun,","
R14593	T21941	T21940	arg2Of	begun,has
R14594	T21943	T21941	arg2Of	emerge,begun
R14595	T21943	T21942	arg1Of	emerge,to
R14596	T21943	T21945	arg1Of	emerge,well
R14597	T21943	T21946	arg1Of	emerge,[
R14598	T21943	T21949	arg1Of	emerge,","
R14599	T21943	T21950	arg1Of	emerge,[
R14600	T21945	T21944	arg1Of	well,as
R14601	T21947	T21946	arg2Of	45,[
R14602	T21948	T21946	arg3Of	],[
R14603	T21951	T21950	arg2Of	47,[
R14604	T21952	T21950	arg3Of	],[
R14605	T21954	T21953	arg1Of	data,Our
R14606	T21954	T21955	arg1Of	data,demonstrates
R14607	T21958	T21955	arg2Of	mode,demonstrates
R14608	T21958	T21956	arg1Of	mode,a
R14609	T21958	T21957	arg1Of	mode,new
R14610	T21958	T21959	arg1Of	mode,of
R14611	T21958	T21964	arg1Of	mode,by
R14612	T21961	T21959	arg2Of	regulation,of
R14613	T21961	T21960	arg1Of	regulation,necrosis-specific
R14614	T21961	T21962	arg1Of	regulation,of
R14615	T21963	T21962	arg2Of	Akt,of
R14616	T21966	T21964	arg2Of	kinase,by
R14617	T21966	T21965	arg1Of	kinase,RIP1
R14618	T21971	T21969	arg2Of	is,while
R14619	T21972	T21971	arg2Of	possible,is
R14620	T21975	T21974	arg1Of	targets,necroptosis-specific
R14621	T21975	T21976	arg1Of	targets,of
R14622	T21975	T21978	arg1Of	targets,exist
R14623	T21977	T21976	arg2Of	Akt,of
R14624	T21978	T21970	arg1Of	exist,it
R14625	T21978	T21971	arg1Of	exist,is
R14626	T21978	T21972	arg1Of	exist,possible
R14627	T21978	T21973	arg1Of	exist,that
R14628	T21981	T21980	arg1Of	regulation,this
R14629	T21981	T21983	arg1Of	regulation,involves
R14630	T21983	T21967	arg1Of	involves,Importantly
R14631	T21983	T21968	arg1Of	involves,","
R14632	T21983	T21969	arg1Of	involves,while
R14633	T21983	T21979	arg1Of	involves,","
R14634	T21983	T21982	arg1Of	involves,clearly
R14635	T21985	T21983	arg2Of	number,involves
R14636	T21985	T21984	arg1Of	number,a
R14637	T21985	T21986	arg1Of	number,of
R14638	T21988	T21987	arg1Of	established,well
R14639	T21990	T21986	arg2Of	targets,of
R14640	T21990	T21988	arg1Of	targets,established
R14641	T21990	T21989	arg1Of	targets,Akt
R14642	T21990	T21991	arg1Of	targets,including
R14643	T21992	T21994	arg1Of	mTORC1,and
R14644	T21994	T21991	arg2Of	and,including
R14645	T21994	T21993	arg1Of	and,","
R14646	T21997	T21998	arg1Of	GSK-3,","
R14647	T21998	T22001	arg1Of	",",and
R14648	T21999	T21998	arg2Of	FoxO1/4,","
R14649	T22001	T21994	arg2Of	and,and
R14650	T22001	T21995	arg1Of	and,potentially
R14651	T22001	T21996	arg1Of	and,","
R14652	T22001	T22000	arg1Of	and,","
R14653	T22002	T22001	arg2Of	MDM2,and
R14654	T22008	T22007	arg1Of	longer,no
R14655	T22009	T22003	arg1Of	be,Therefore
R14656	T22009	T22004	arg1Of	be,","
R14657	T22009	T22006	arg2Of	be,may
R14658	T22009	T22008	arg1Of	be,longer
R14659	T22010	T22009	arg2Of	safe,be
R14660	T22012	T22005	arg1Of	assume,it
R14661	T22012	T22006	arg1Of	assume,may
R14662	T22012	T22009	arg1Of	assume,be
R14663	T22012	T22010	arg1Of	assume,safe
R14664	T22012	T22011	arg1Of	assume,to
R14665	T22014	T22015	arg1Of	activation,of
R14666	T22014	T22018	arg1Of	activation,reflects
R14667	T22016	T22015	arg2Of	Akt,of
R14668	T22018	T22017	arg1Of	reflects,universally
R14669	T22018	T22021	arg1Of	reflects,nor
R14670	T22018	T22022	arg1Of	reflects,that
R14671	T22020	T22018	arg2Of	signaling,reflects
R14672	T22020	T22019	arg1Of	signaling,pro-survival
R14673	T22022	T22012	arg2Of	that,assume
R14674	T22022	T22013	arg1Of	that,that
R14675	T22024	T22023	arg1Of	inhibition,its
R14676	T22024	T22025	arg1Of	inhibition,will
R14677	T22024	T22026	arg1Of	inhibition,lead
R14678	T22026	T22022	arg2Of	lead,that
R14679	T22026	T22025	arg2Of	lead,will
R14680	T22026	T22027	arg1Of	lead,to
R14681	T22030	T22027	arg2Of	death,to
R14682	T22030	T22028	arg1Of	death,more
R14683	T22030	T22029	arg1Of	death,cell
R14684	T22031	T22032	arg1Of	It,is
R14685	T22031	T22033	arg1Of	It,tempting
R14686	T22031	T22035	arg1Of	It,speculate
R14687	T22033	T22032	arg2Of	tempting,is
R14688	T22035	T22033	arg2Of	speculate,tempting
R14689	T22035	T22034	arg1Of	speculate,to
R14690	T22037	T22038	arg1Of	rather,than
R14691	T22039	T22038	arg2Of	serving,than
R14692	T22042	T22041	arg1Of	pro-survival,universally
R14693	T22043	T22039	arg2Of	role,serving
R14694	T22043	T22040	arg1Of	role,a
R14695	T22043	T22042	arg1Of	role,pro-survival
R14696	T22047	T22045	arg1Of	pathway,the
R14697	T22047	T22046	arg1Of	pathway,Akt
R14698	T22047	T22048	arg1Of	pathway,may
R14699	T22047	T22049	arg1Of	pathway,function
R14700	T22047	T22051	arg1Of	pathway,promote
R14701	T22049	T22035	arg2Of	function,speculate
R14702	T22049	T22036	arg1Of	function,that
R14703	T22049	T22037	arg1Of	function,rather
R14704	T22049	T22044	arg1Of	function,","
R14705	T22049	T22048	arg2Of	function,may
R14706	T22051	T22049	arg2Of	promote,function
R14707	T22051	T22050	arg1Of	promote,to
R14708	T22053	T22052	arg1Of	fates,cell
R14709	T22054	T22053	arg1Of	alternative,fates
R14710	T22054	T22055	arg1Of	alternative,to
R14711	T22055	T22061	arg1Of	to,to
R14712	T22056	T22055	arg2Of	apoptosis,to
R14713	T22056	T22057	arg1Of	apoptosis,","
R14714	T22056	T22058	arg1Of	apoptosis,ranging
R14715	T22058	T22059	arg1Of	ranging,from
R14716	T22060	T22059	arg2Of	survival,from
R14717	T22064	T22051	arg2Of	death,promote
R14718	T22064	T22054	arg1Of	death,alternative
R14719	T22064	T22062	arg1Of	death,non-apoptotic
R14720	T22064	T22063	arg1Of	death,cell
R14721	T22067	T22065	arg1Of	decision,The
R14722	T22067	T22066	arg1Of	decision,final
R14723	T22067	T22068	arg1Of	decision,between
R14724	T22067	T22072	arg1Of	decision,may
R14725	T22067	T22073	arg1Of	decision,depend
R14726	T22069	T22070	arg1Of	survival,and
R14727	T22070	T22068	arg2Of	and,between
R14728	T22071	T22070	arg2Of	death,and
R14729	T22073	T22072	arg2Of	depend,may
R14730	T22073	T22074	arg1Of	depend,on
R14731	T22075	T22076	arg1Of	additional,","
R14732	T22077	T22076	arg2Of	Akt-independent,","
R14733	T22078	T22074	arg2Of	inputs,on
R14734	T22078	T22075	arg1Of	inputs,additional
R14735	T22078	T22077	arg1Of	inputs,Akt-independent
R14736	T22078	T22079	arg1Of	inputs,","
R14737	T22078	T22081	arg1Of	inputs,as
R14738	T22081	T22080	arg1Of	as,such
R14739	T22083	T22081	arg2Of	status,as
R14740	T22083	T22082	arg1Of	status,the
R14741	T22083	T22084	arg1Of	status,of
R14742	T22086	T22085	arg1Of	kinase,RIP1
R14743	T22086	T22087	arg1Of	kinase,","
R14744	T22087	T22096	arg1Of	",",or
R14745	T22088	T22087	arg2Of	expression,","
R14746	T22088	T22089	arg1Of	expression,of
R14747	T22092	T22089	arg2Of	factors,of
R14748	T22092	T22090	arg1Of	factors,particular
R14749	T22092	T22091	arg1Of	factors,oncogenic
R14750	T22092	T22093	arg1Of	factors,[
R14751	T22094	T22093	arg2Of	45,[
R14752	T22095	T22093	arg3Of	],[
R14753	T22096	T22084	arg2Of	or,of
R14754	T22099	T22096	arg2Of	stress,or
R14755	T22099	T22097	arg1Of	stress,excessive
R14756	T22099	T22098	arg1Of	stress,metabolic
R14757	T22099	T22100	arg1Of	stress,[
R14758	T22101	T22100	arg2Of	47,[
R14759	T22102	T22100	arg3Of	],[
R14760	T22104	T22103	arg1Of	mechanism,Another
R14761	T22104	T22105	arg1Of	mechanism,that
R14762	T22104	T22106	arg1Of	mechanism,should
R14763	T22104	T22107	arg1Of	mechanism,be
R14764	T22104	T22108	arg2Of	mechanism,considered
R14765	T22104	T22119	arg1Of	mechanism,is
R14766	T22104	T22120	arg1Of	mechanism,autophagy
R14767	T22108	T22106	arg2Of	considered,should
R14768	T22108	T22107	arg2Of	considered,be
R14769	T22108	T22109	arg1Of	considered,in
R14770	T22110	T22109	arg2Of	conjunction,in
R14771	T22110	T22111	arg1Of	conjunction,with
R14772	T22113	T22111	arg2Of	regulation,with
R14773	T22113	T22112	arg1Of	regulation,the
R14774	T22113	T22114	arg1Of	regulation,of
R14775	T22113	T22117	arg1Of	regulation,by
R14776	T22116	T22114	arg2Of	death,of
R14777	T22116	T22115	arg1Of	death,cell
R14778	T22118	T22117	arg2Of	Akt,by
R14779	T22120	T22119	arg2Of	autophagy,is
R14780	T22122	T22121	arg1Of	activation,Akt
R14781	T22122	T22123	arg1Of	activation,leads
R14782	T22123	T22124	arg1Of	leads,to
R14783	T22123	T22129	arg1Of	leads,through
R14784	T22126	T22124	arg2Of	inhibition,to
R14785	T22126	T22125	arg1Of	inhibition,the
R14786	T22126	T22127	arg1Of	inhibition,of
R14787	T22128	T22127	arg2Of	autophagy,of
R14788	T22130	T22129	arg2Of	activation,through
R14789	T22130	T22131	arg1Of	activation,of
R14790	T22132	T22131	arg2Of	mTOR,of
R14791	T22132	T22133	arg1Of	mTOR,[
R14792	T22134	T22133	arg2Of	48,[
R14793	T22135	T22133	arg3Of	],[
R14794	T22137	T22136	arg1Of	role,The
R14795	T22137	T22138	arg1Of	role,of
R14796	T22137	T22140	arg1Of	role,in
R14797	T22137	T22143	arg1Of	role,in
R14798	T22137	T22145	arg1Of	role,is
R14799	T22137	T22147	arg1Of	role,complex
R14800	T22139	T22138	arg2Of	autophagy,of
R14801	T22142	T22140	arg2Of	death,in
R14802	T22142	T22141	arg1Of	death,cell
R14803	T22144	T22143	arg2Of	general,in
R14804	T22145	T22148	arg1Of	is,and
R14805	T22147	T22145	arg2Of	complex,is
R14806	T22147	T22146	arg1Of	complex,very
R14807	T22149	T22150	arg1Of	it,can
R14808	T22149	T22152	arg1Of	it,promote
R14809	T22149	T22154	arg1Of	it,inhibit
R14810	T22152	T22153	arg1Of	promote,and
R14811	T22153	T22148	arg2Of	and,and
R14812	T22153	T22150	arg2Of	and,can
R14813	T22153	T22151	arg1Of	and,both
R14814	T22153	T22156	arg1Of	and,in
R14815	T22154	T22153	arg2Of	inhibit,and
R14816	T22155	T22152	arg2Of	necroptosis,promote
R14817	T22155	T22154	arg2Of	necroptosis,inhibit
R14818	T22158	T22156	arg2Of	situations,in
R14819	T22158	T22157	arg1Of	situations,various
R14820	T22160	T22159	arg1Of	studies,Several
R14821	T22160	T22161	arg1Of	studies,suggested
R14822	T22163	T22164	arg1Of	activation,of
R14823	T22163	T22166	arg1Of	activation,promotes
R14824	T22165	T22164	arg2Of	autophagy,of
R14825	T22166	T22161	arg2Of	promotes,suggested
R14826	T22166	T22162	arg1Of	promotes,that
R14827	T22167	T22166	arg2Of	necroptosis,promotes
R14828	T22167	T22168	arg2Of	necroptosis,induced
R14829	T22170	T22168	arg1Of	zVAD.fmk,induced
R14830	T22170	T22169	arg2Of	zVAD.fmk,by
R14831	T22170	T22171	arg1Of	zVAD.fmk,in
R14832	T22173	T22171	arg2Of	cells,in
R14833	T22173	T22172	arg1Of	cells,L929
R14834	T22173	T22174	arg1Of	cells,[
R14835	T22173	T22177	arg1Of	cells,","
R14836	T22173	T22178	arg1Of	cells,[
R14837	T22175	T22174	arg2Of	11,[
R14838	T22176	T22174	arg3Of	],[
R14839	T22179	T22178	arg2Of	14,[
R14840	T22180	T22178	arg3Of	],[
R14841	T22181	T22182	arg1Of	Others,","
R14842	T22181	T22183	arg1Of	Others,including
R14843	T22181	T22189	arg1Of	Others,have
R14844	T22181	T22190	arg1Of	Others,found
R14845	T22183	T22185	arg1Of	including,in
R14846	T22184	T22183	arg2Of	ourselves,including
R14847	T22187	T22185	arg2Of	data,in
R14848	T22187	T22186	arg1Of	data,unpublished
R14849	T22190	T22188	arg1Of	found,","
R14850	T22190	T22189	arg2Of	found,have
R14851	T22192	T22193	arg1Of	inihibition,of
R14852	T22192	T22195	arg1Of	inihibition,promotes
R14853	T22194	T22193	arg2Of	autophagy,of
R14854	T22195	T22190	arg2Of	promotes,found
R14855	T22195	T22191	arg1Of	promotes,that
R14856	T22195	T22197	arg1Of	promotes,by
R14857	T22195	T22199	arg1Of	promotes,[
R14858	T22196	T22195	arg2Of	necroptosis,promotes
R14859	T22198	T22197	arg2Of	TNFα,by
R14860	T22200	T22199	arg2Of	49,[
R14861	T22201	T22199	arg3Of	],[
R14862	T22202	T22203	arg1Of	This,suggests
R14863	T22206	T22205	arg1Of	inhibition,the
R14864	T22206	T22207	arg1Of	inhibition,of
R14865	T22206	T22209	arg1Of	inhibition,by
R14866	T22206	T22216	arg1Of	inhibition,may
R14867	T22206	T22217	arg1Of	inhibition,contribute
R14868	T22208	T22207	arg2Of	autophagy,of
R14869	T22210	T22211	arg1Of	Akt,or
R14870	T22211	T22209	arg2Of	or,by
R14871	T22211	T22213	arg1Of	or,in
R14872	T22212	T22211	arg2Of	mTOR,or
R14873	T22215	T22213	arg2Of	system,in
R14874	T22215	T22214	arg1Of	system,our
R14875	T22217	T22203	arg2Of	contribute,suggests
R14876	T22217	T22204	arg1Of	contribute,that
R14877	T22217	T22216	arg2Of	contribute,may
R14878	T22217	T22218	arg1Of	contribute,to
R14879	T22219	T22218	arg2Of	necroptosis,to
R14880	T22219	T22220	arg2Of	necroptosis,induced
R14881	T22222	T22220	arg1Of	TNFα,induced
R14882	T22222	T22221	arg2Of	TNFα,by
R14883	T22222	T22231	arg2Of	TNFα,reconcile
R14884	T22227	T22223	arg1Of	is,","
R14885	T22227	T22224	arg1Of	is,however
R14886	T22227	T22225	arg1Of	is,","
R14887	T22229	T22227	arg2Of	difficult,is
R14888	T22229	T22228	arg1Of	difficult,more
R14889	T22231	T22226	arg1Of	reconcile,it
R14890	T22231	T22227	arg1Of	reconcile,is
R14891	T22231	T22229	arg1Of	reconcile,difficult
R14892	T22231	T22230	arg1Of	reconcile,to
R14893	T22231	T22232	arg1Of	reconcile,with
R14894	T22235	T22232	arg2Of	role,with
R14895	T22235	T22233	arg1Of	role,the
R14896	T22235	T22234	arg1Of	role,positive
R14897	T22235	T22236	arg1Of	role,of
R14898	T22235	T22239	arg1Of	role,in
R14899	T22238	T22236	arg2Of	proteins,of
R14900	T22238	T22237	arg1Of	proteins,these
R14901	T22241	T22239	arg2Of	death,in
R14902	T22241	T22240	arg1Of	death,zVAD-induced
R14903	T22245	T22244	arg1Of	identification,further
R14904	T22245	T22246	arg1Of	identification,of
R14905	T22245	T22258	arg1Of	identification,is
R14906	T22245	T22259	arg2Of	identification,required
R14907	T22245	T22262	arg1Of	identification,understand
R14908	T22248	T22246	arg2Of	factors,of
R14909	T22248	T22247	arg1Of	factors,the
R14910	T22248	T22249	arg1Of	factors,differentiating
R14911	T22249	T22250	arg1Of	differentiating,between
R14912	T22251	T22252	arg1Of	pro-death,and
R14913	T22253	T22252	arg2Of	pro-survival,and
R14914	T22254	T22250	arg2Of	autophagy,between
R14915	T22254	T22251	arg1Of	autophagy,pro-death
R14916	T22254	T22253	arg1Of	autophagy,pro-survival
R14917	T22254	T22255	arg1Of	autophagy,in
R14918	T22257	T22255	arg2Of	cells,in
R14919	T22257	T22256	arg1Of	cells,mammalian
R14920	T22259	T22242	arg1Of	required,Clearly
R14921	T22259	T22243	arg1Of	required,","
R14922	T22259	T22258	arg2Of	required,is
R14923	T22262	T22259	arg3Of	understand,required
R14924	T22262	T22260	arg1Of	understand,to
R14925	T22262	T22261	arg1Of	understand,better
R14926	T22262	T22269	arg1Of	understand,by
R14927	T22264	T22262	arg2Of	role,understand
R14928	T22264	T22263	arg1Of	role,its
R14929	T22264	T22265	arg1Of	role,in
R14930	T22268	T22265	arg2Of	necroptosis,in
R14931	T22268	T22266	arg1Of	necroptosis,the
R14932	T22268	T22267	arg1Of	necroptosis,regulation
R14933	T22271	T22269	arg2Of	pathway,by
R14934	T22271	T22270	arg1Of	pathway,Akt
R14935	T22275	T22274	arg1Of	data,our
R14936	T22275	T22276	arg1Of	data,revealed
R14937	T22276	T22272	arg1Of	revealed,Importantly
R14938	T22276	T22273	arg1Of	revealed,","
R14939	T22280	T22278	arg1Of	signaling,RIP1
R14940	T22280	T22279	arg1Of	signaling,kinase
R14941	T22280	T22281	arg1Of	signaling,to
R14942	T22280	T22283	arg1Of	signaling,is
R14943	T22282	T22281	arg2Of	Akt,to
R14944	T22283	T22276	arg2Of	is,revealed
R14945	T22283	T22277	arg1Of	is,that
R14946	T22286	T22283	arg2Of	feature,is
R14947	T22286	T22284	arg1Of	feature,a
R14948	T22286	T22285	arg1Of	feature,general
R14949	T22286	T22287	arg1Of	feature,of
R14950	T22286	T22290	arg1Of	feature,that
R14951	T22286	T22291	arg1Of	feature,is
R14952	T22286	T22292	arg2Of	feature,observed
R14953	T22289	T22287	arg2Of	signaling,of
R14954	T22289	T22288	arg1Of	signaling,necroptotic
R14955	T22292	T22291	arg2Of	observed,is
R14956	T22292	T22293	arg1Of	observed,in
R14957	T22296	T22293	arg2Of	types,in
R14958	T22296	T22294	arg1Of	types,multiple
R14959	T22296	T22295	arg1Of	types,cell
R14960	T22300	T22297	arg2Of	time,At
R14961	T22300	T22298	arg1Of	time,the
R14962	T22300	T22299	arg1Of	time,same
R14963	T22303	T22302	arg1Of	significance,the
R14964	T22303	T22304	arg1Of	significance,of
R14965	T22303	T22307	arg1Of	significance,varies
R14966	T22306	T22304	arg2Of	connection,of
R14967	T22306	T22305	arg1Of	connection,this
R14968	T22307	T22297	arg1Of	varies,At
R14969	T22307	T22301	arg1Of	varies,","
R14970	T22307	T22308	arg1Of	varies,in
R14971	T22313	T22308	arg2Of	fashion,in
R14972	T22313	T22309	arg1Of	fashion,a
R14973	T22313	T22310	arg1Of	fashion,cell
R14974	T22313	T22311	arg1Of	fashion,type
R14975	T22313	T22312	arg1Of	fashion,specific
R14976	T22319	T22317	arg1Of	fibroblasts,mouse
R14977	T22319	T22318	arg1Of	fibroblasts,lung
R14978	T22319	T22320	arg1Of	fibroblasts,","
R14979	T22320	T22325	arg1Of	",",and
R14980	T22323	T22320	arg2Of	cells,","
R14981	T22323	T22321	arg1Of	cells,FADD-deficient
R14982	T22323	T22322	arg1Of	cells,Jurkat
R14983	T22325	T22316	arg2Of	and,in
R14984	T22325	T22324	arg1Of	and,","
R14985	T22326	T22325	arg2Of	macrophages,and
R14986	T22329	T22328	arg1Of	signaling,Akt
R14987	T22329	T22330	arg1Of	signaling,contributed
R14988	T22330	T22314	arg1Of	contributed,Importantly
R14989	T22330	T22315	arg1Of	contributed,","
R14990	T22330	T22316	arg1Of	contributed,in
R14991	T22330	T22327	arg1Of	contributed,","
R14992	T22330	T22332	arg1Of	contributed,prominently
R14993	T22330	T22333	arg1Of	contributed,to
R14994	T22330	T22345	arg1Of	contributed,se
R14995	T22330	T22346	arg1Of	contributed,","
R14996	T22330	T22347	arg1Of	contributed,unlike
R14997	T22332	T22331	arg1Of	prominently,more
R14998	T22335	T22334	arg1Of	increase,an
R14999	T22335	T22336	arg1Of	increase,in
R15000	T22335	T22341	arg1Of	increase,than
R15001	T22338	T22336	arg2Of	synthesis,in
R15002	T22338	T22337	arg1Of	synthesis,TNFα
R15003	T22341	T22333	arg2Of	than,to
R15004	T22341	T22339	arg1Of	than,","
R15005	T22341	T22340	arg1Of	than,rather
R15006	T22343	T22341	arg2Of	death,than
R15007	T22343	T22342	arg1Of	death,cell
R15008	T22345	T22344	arg1Of	se,per
R15009	T22349	T22347	arg2Of	role,unlike
R15010	T22349	T22348	arg1Of	role,its
R15011	T22349	T22350	arg1Of	role,in
R15012	T22352	T22350	arg2Of	cells,in
R15013	T22352	T22351	arg1Of	cells,L929
R15014	T22355	T22353	arg1Of	study,A
R15015	T22355	T22354	arg1Of	study,recent
R15016	T22355	T22356	arg1Of	study,[
R15017	T22355	T22359	arg1Of	study,has
R15018	T22355	T22360	arg1Of	study,demonstrated
R15019	T22357	T22356	arg2Of	15,[
R15020	T22358	T22356	arg3Of	],[
R15021	T22360	T22359	arg2Of	demonstrated,has
R15022	T22364	T22363	arg2Of	addition,in
R15023	T22364	T22365	arg1Of	addition,to
R15024	T22367	T22365	arg2Of	role,to
R15025	T22367	T22366	arg1Of	role,its
R15026	T22367	T22368	arg1Of	role,in
R15027	T22369	T22368	arg2Of	necroptosis,in
R15028	T22371	T22372	arg1Of	RIP1,plays
R15029	T22371	T22377	arg1Of	RIP1,mediating
R15030	T22372	T22360	arg2Of	plays,demonstrated
R15031	T22372	T22361	arg1Of	plays,that
R15032	T22372	T22362	arg1Of	plays,","
R15033	T22372	T22363	arg1Of	plays,in
R15034	T22372	T22370	arg1Of	plays,","
R15035	T22372	T22376	arg1Of	plays,in
R15036	T22375	T22372	arg2Of	role,plays
R15037	T22375	T22373	arg1Of	role,an
R15038	T22375	T22374	arg1Of	role,important
R15039	T22377	T22376	arg2Of	mediating,in
R15040	T22379	T22377	arg2Of	production,mediating
R15041	T22379	T22378	arg1Of	production,the
R15042	T22379	T22380	arg1Of	production,of
R15043	T22381	T22380	arg2Of	TNFα,of
R15044	T22383	T22382	arg1Of	data,These
R15045	T22383	T22384	arg1Of	data,emphasize
R15046	T22383	T22393	arg1Of	data,highlight
R15047	T22383	T22405	arg1Of	data,accompanying
R15048	T22384	T22392	arg1Of	emphasize,and
R15049	T22387	T22384	arg2Of	complexity,emphasize
R15050	T22387	T22385	arg1Of	complexity,the
R15051	T22387	T22386	arg1Of	complexity,emerging
R15052	T22387	T22388	arg1Of	complexity,of
R15053	T22391	T22388	arg2Of	mechanisms,of
R15054	T22391	T22389	arg1Of	mechanisms,necroptotic
R15055	T22391	T22390	arg1Of	mechanisms,signaling
R15056	T22392	T22403	arg1Of	and,","
R15057	T22392	T22405	modOf	and,accompanying
R15058	T22392	T22414	arg1Of	and,","
R15059	T22392	T22415	arg1Of	and,[
R15060	T22392	T22418	arg1Of	and,","
R15061	T22392	T22419	arg1Of	and,[
R15062	T22393	T22392	arg2Of	highlight,and
R15063	T22396	T22393	arg2Of	contribution,highlight
R15064	T22396	T22394	arg1Of	contribution,the
R15065	T22396	T22395	arg1Of	contribution,major
R15066	T22396	T22397	arg1Of	contribution,of
R15067	T22396	T22399	arg1Of	contribution,to
R15068	T22398	T22397	arg2Of	Akt,of
R15069	T22402	T22399	arg2Of	signaling,to
R15070	T22402	T22400	arg2Of	signaling,increased
R15071	T22402	T22401	arg1Of	signaling,inflammatory
R15072	T22405	T22404	arg1Of	accompanying,specifically
R15073	T22407	T22405	arg2Of	form,accompanying
R15074	T22407	T22406	arg1Of	form,this
R15075	T22407	T22408	arg1Of	form,of
R15076	T22410	T22408	arg2Of	necrosis,of
R15077	T22410	T22409	arg2Of	necrosis,regulated
R15078	T22410	T22411	arg1Of	necrosis,[
R15079	T22412	T22411	arg2Of	5,[
R15080	T22413	T22411	arg3Of	],[
R15081	T22416	T22415	arg2Of	6,[
R15082	T22417	T22415	arg3Of	],[
R15083	T22420	T22419	arg2Of	10,[
R15084	T22421	T22419	arg3Of	],[
R15085	T22423	T22422	arg1Of	inflammation,Robust
R15086	T22423	T22424	arg1Of	inflammation,is
R15087	T22424	T22450	arg1Of	is,[
R15088	T22424	T22453	arg1Of	is,","
R15089	T22424	T22454	arg1Of	is,[
R15090	T22424	T22457	arg1Of	is,","
R15091	T22424	T22458	arg1Of	is,[
R15092	T22424	T22461	arg1Of	is,","
R15093	T22424	T22462	arg1Of	is,[
R15094	T22424	T22465	arg1Of	is,","
R15095	T22424	T22466	arg1Of	is,[
R15096	T22425	T22424	arg2Of	one,is
R15097	T22425	T22426	arg1Of	one,of
R15098	T22425	T22431	arg1Of	one,of
R15099	T22425	T22446	arg1Of	one,vitro
R15100	T22425	T22449	arg1Of	one,vivo
R15101	T22429	T22428	arg1Of	important,most
R15102	T22430	T22426	arg2Of	consequences,of
R15103	T22430	T22427	arg1Of	consequences,the
R15104	T22430	T22429	arg1Of	consequences,important
R15105	T22434	T22432	arg1Of	death,necrotic
R15106	T22434	T22433	arg1Of	death,cell
R15107	T22434	T22437	arg1Of	death,as
R15108	T22437	T22431	arg2Of	as,of
R15109	T22437	T22435	arg1Of	as,as
R15110	T22437	T22436	arg1Of	as,well
R15111	T22437	T22443	arg1Of	as,","
R15112	T22440	T22437	arg2Of	subtype,as
R15113	T22440	T22438	arg1Of	subtype,its
R15114	T22440	T22439	arg2Of	subtype,regulated
R15115	T22440	T22441	arg1Of	subtype,","
R15116	T22442	T22441	arg2Of	necroptosis,","
R15117	T22446	T22445	arg1Of	vitro,in
R15118	T22446	T22447	arg1Of	vitro,and
R15119	T22447	T22444	arg1Of	and,both
R15120	T22449	T22447	arg2Of	vivo,and
R15121	T22449	T22448	arg1Of	vivo,in
R15122	T22451	T22450	arg2Of	1,[
R15123	T22452	T22450	arg3Of	],[
R15124	T22455	T22454	arg2Of	5,[
R15125	T22456	T22454	arg3Of	],[
R15126	T22459	T22458	arg2Of	6,[
R15127	T22460	T22458	arg3Of	],[
R15128	T22463	T22462	arg2Of	50,[
R15129	T22464	T22462	arg3Of	],[
R15130	T22467	T22466	arg2Of	51,[
R15131	T22468	T22466	arg3Of	],[
R15132	T22470	T22469	arg1Of	results,Our
R15133	T22470	T22471	arg1Of	results,highlight
R15134	T22474	T22471	arg2Of	notion,highlight
R15135	T22474	T22472	arg1Of	notion,an
R15136	T22474	T22473	arg1Of	notion,important
R15137	T22476	T22480	arg1Of	inflammation,accompanies
R15138	T22478	T22477	arg1Of	only,not
R15139	T22480	T22474	arg2Of	accompanies,notion
R15140	T22480	T22475	arg1Of	accompanies,that
R15141	T22480	T22478	arg1Of	accompanies,only
R15142	T22480	T22479	arg1Of	accompanies,passively
R15143	T22480	T22482	arg1Of	accompanies,in
R15144	T22480	T22488	arg1Of	accompanies,by
R15145	T22481	T22480	arg2Of	necroptosis,accompanies
R15146	T22484	T22482	arg2Of	variety,in
R15147	T22484	T22483	arg1Of	variety,a
R15148	T22484	T22485	arg1Of	variety,of
R15149	T22487	T22485	arg2Of	systems,of
R15150	T22487	T22486	arg1Of	systems,cellular
R15151	T22490	T22488	arg2Of	virtue,by
R15152	T22490	T22489	arg1Of	virtue,the
R15153	T22490	T22491	arg1Of	virtue,of
R15154	T22493	T22491	arg2Of	loss,of
R15155	T22493	T22492	arg1Of	loss,rapid
R15156	T22493	T22494	arg1Of	loss,of
R15157	T22493	T22506	arg1Of	loss,that
R15158	T22493	T22514	arg1Of	loss,of
R15159	T22494	T22504	arg1Of	of,but
R15160	T22497	T22494	arg2Of	integrity,of
R15161	T22497	T22495	arg1Of	integrity,plasma
R15162	T22497	T22496	arg1Of	integrity,membrane
R15163	T22497	T22498	arg1Of	integrity,characteristic
R15164	T22498	T22499	arg1Of	characteristic,for
R15165	T22502	T22499	arg2Of	death,for
R15166	T22502	T22500	arg1Of	death,necrotic
R15167	T22502	T22501	arg1Of	death,cell
R15168	T22504	T22503	arg1Of	but,","
R15169	T22504	T22505	arg1Of	but,also
R15170	T22506	T22504	arg2Of	that,but
R15171	T22507	T22508	arg1Of	it,is
R15172	T22508	T22506	arg2Of	is,that
R15173	T22510	T22511	arg1Of	intrinsic,and
R15174	T22512	T22511	arg2Of	regulated,and
R15175	T22513	T22508	arg2Of	component,is
R15176	T22513	T22509	arg1Of	component,an
R15177	T22513	T22510	arg1Of	component,intrinsic
R15178	T22513	T22512	arg1Of	component,regulated
R15179	T22515	T22514	arg2Of	necroptosis,of
R15180	T22515	T22517	arg1Of	necroptosis,to
R15181	T22517	T22516	arg1Of	to,due
R15182	T22520	T22517	arg2Of	activation,to
R15183	T22520	T22518	arg1Of	activation,the
R15184	T22520	T22519	arg1Of	activation,specific
R15185	T22520	T22521	arg1Of	activation,of
R15186	T22520	T22524	arg1Of	activation,by
R15187	T22523	T22521	arg2Of	synthesis,of
R15188	T22523	T22522	arg1Of	synthesis,TNFα
R15189	T22526	T22524	arg2Of	kinases,by
R15190	T22526	T22525	arg1Of	kinases,RIP1/Akt
R15191	T22530	T22529	arg1Of	pathway,this
R15192	T22530	T22531	arg1Of	pathway,may
R15193	T22530	T22532	arg1Of	pathway,represent
R15194	T22532	T22527	arg1Of	represent,Therefore
R15195	T22532	T22528	arg1Of	represent,","
R15196	T22532	T22531	arg2Of	represent,may
R15197	T22536	T22532	arg2Of	target,represent
R15198	T22536	T22533	arg1Of	target,a
R15199	T22536	T22534	arg1Of	target,new
R15200	T22536	T22535	arg1Of	target,molecular
R15201	T22536	T22537	arg1Of	target,for
R15202	T22539	T22537	arg2Of	inhibition,for
R15203	T22539	T22538	arg1Of	inhibition,the
R15204	T22539	T22540	arg1Of	inhibition,of
R15205	T22543	T22540	arg2Of	signaling,of
R15206	T22543	T22541	arg1Of	signaling,pathologic
R15207	T22543	T22542	arg1Of	signaling,inflammatory
R15208	T22546	T22545	arg1Of	vivo,in
R15209	T22547	T22544	arg1Of	data,Initial
R15210	T22547	T22546	arg1Of	data,vivo
R15211	T22547	T22548	arg1Of	data,appears
R15212	T22547	T22550	arg1Of	data,support
R15213	T22550	T22548	arg2Of	support,appears
R15214	T22550	T22549	arg1Of	support,to
R15215	T22552	T22550	arg2Of	notion,support
R15216	T22552	T22551	arg1Of	notion,this
R15217	T22555	T22553	arg1Of	papers,Two
R15218	T22555	T22554	arg1Of	papers,recent
R15219	T22555	T22556	arg1Of	papers,showed
R15220	T22559	T22558	arg1Of	loss,the
R15221	T22559	T22560	arg1Of	loss,of
R15222	T22559	T22573	arg1Of	loss,unleashes
R15223	T22559	T22584	arg1Of	loss,resulting
R15224	T22561	T22560	arg2Of	control,of
R15225	T22561	T22562	arg1Of	control,over
R15226	T22561	T22566	arg1Of	control,by
R15227	T22565	T22562	arg2Of	activities,over
R15228	T22565	T22563	arg1Of	activities,RIP1/RIP3
R15229	T22565	T22564	arg1Of	activities,kinase
R15230	T22567	T22568	arg1Of	FADD,and
R15231	T22568	T22566	arg2Of	and,by
R15232	T22568	T22570	arg1Of	and,in
R15233	T22569	T22568	arg2Of	caspase-8,and
R15234	T22572	T22570	arg2Of	cells,in
R15235	T22572	T22571	arg1Of	cells,epithelial
R15236	T22573	T22556	arg2Of	unleashes,showed
R15237	T22573	T22557	arg1Of	unleashes,that
R15238	T22573	T22583	arg1Of	unleashes,","
R15239	T22577	T22573	arg2Of	cycle,unleashes
R15240	T22577	T22574	arg1Of	cycle,a
R15241	T22577	T22575	arg1Of	cycle,feed
R15242	T22577	T22576	arg1Of	cycle,forward
R15243	T22577	T22578	arg1Of	cycle,of
R15244	T22579	T22580	arg1Of	necroptosis,and
R15245	T22581	T22580	arg2Of	TNFα,and
R15246	T22582	T22578	arg2Of	production,of
R15247	T22582	T22579	arg1Of	production,necroptosis
R15248	T22582	T22581	arg1Of	production,TNFα
R15249	T22584	T22573	arg3Of	resulting,unleashes
R15250	T22584	T22585	arg1Of	resulting,in
R15251	T22584	T22594	arg1Of	resulting,","
R15252	T22584	T22595	arg1Of	resulting,possibly
R15253	T22584	T22596	arg1Of	resulting,","
R15254	T22584	T22597	arg1Of	resulting,in
R15255	T22584	T22605	arg1Of	resulting,","
R15256	T22584	T22606	arg1Of	resulting,[
R15257	T22587	T22585	arg2Of	development,in
R15258	T22587	T22586	arg1Of	development,the
R15259	T22587	T22588	arg1Of	development,of
R15260	T22590	T22588	arg2Of	inflammation,of
R15261	T22590	T22589	arg1Of	inflammation,intestinal
R15262	T22590	T22591	arg1Of	inflammation,in
R15263	T22590	T22593	arg1Of	inflammation,and
R15264	T22592	T22591	arg2Of	mice,in
R15265	T22598	T22597	arg2Of	patients,in
R15266	T22598	T22599	arg1Of	patients,with
R15267	T22601	T22599	arg2Of	disease,with
R15268	T22601	T22600	arg1Of	disease,Crohn’s
R15269	T22601	T22602	arg1Of	disease,[
R15270	T22603	T22602	arg2Of	4,[
R15271	T22604	T22602	arg3Of	],[
R15272	T22607	T22606	arg2Of	5,[
R15273	T22608	T22606	arg3Of	],[
R15274	T22611	T22609	arg1Of	production,This
R15275	T22611	T22610	arg2Of	production,increased
R15276	T22611	T22612	arg1Of	production,of
R15277	T22611	T22614	arg1Of	production,during
R15278	T22611	T22616	arg1Of	production,may
R15279	T22611	T22618	arg1Of	production,be
R15280	T22611	T22619	arg1Of	production,important
R15281	T22613	T22612	arg2Of	TNFα,of
R15282	T22615	T22614	arg2Of	necroptosis,during
R15283	T22618	T22616	arg2Of	be,may
R15284	T22618	T22617	arg1Of	be,also
R15285	T22619	T22618	arg2Of	important,be
R15286	T22619	T22620	arg1Of	important,for
R15287	T22623	T22620	arg2Of	diseases,for
R15288	T22623	T22621	arg1Of	diseases,acute
R15289	T22623	T22622	arg1Of	diseases,necrotizing
R15290	T22623	T22624	arg1Of	diseases,","
R15291	T22623	T22626	arg1Of	diseases,as
R15292	T22623	T22633	arg1Of	diseases,","
R15293	T22623	T22634	arg1Of	diseases,where
R15294	T22626	T22625	arg1Of	as,such
R15295	T22627	T22626	arg2Of	necrotizing,as
R15296	T22628	T22629	arg1Of	pancreatitis,and
R15297	T22629	T22627	arg2Of	and,necrotizing
R15298	T22632	T22629	arg2Of	infections,and
R15299	T22632	T22630	arg1Of	infections,acute
R15300	T22632	T22631	arg1Of	infections,bacterial
R15301	T22636	T22635	arg1Of	inflammation,hyper-acute
R15302	T22636	T22637	arg1Of	inflammation,accompanying
R15303	T22636	T22641	arg1Of	inflammation,is
R15304	T22640	T22637	arg2Of	death,accompanying
R15305	T22640	T22638	arg1Of	death,necrotic
R15306	T22640	T22639	arg1Of	death,cell
R15307	T22641	T22634	arg2Of	is,where
R15308	T22644	T22641	arg2Of	cause,is
R15309	T22644	T22642	arg1Of	cause,the
R15310	T22644	T22643	arg1Of	cause,primary
R15311	T22644	T22645	arg1Of	cause,of
R15312	T22648	T22646	arg1Of	failure,multiple
R15313	T22648	T22647	arg1Of	failure,organ
R15314	T22648	T22649	arg1Of	failure,and
R15315	T22649	T22645	arg2Of	and,of
R15316	T22651	T22649	arg2Of	death,and
R15318	T22654	T22652	arg2Of	lines,Along
R15319	T22654	T22653	arg1Of	lines,these
R15320	T22658	T22656	arg1Of	paper,another
R15321	T22658	T22657	arg1Of	paper,recent
R15322	T22658	T22659	arg1Of	paper,by
R15323	T22658	T22663	arg1Of	paper,has
R15324	T22658	T22664	arg1Of	paper,shown
R15325	T22662	T22659	arg2Of	al.,by
R15326	T22662	T22660	arg1Of	al.,Duprez
R15327	T22662	T22661	arg1Of	al.,et
R15328	T22664	T22652	arg1Of	shown,Along
R15329	T22664	T22655	arg1Of	shown,","
R15330	T22664	T22663	arg2Of	shown,has
R15331	T22666	T22667	arg1Of	RIP1,and
R15332	T22667	T22669	arg1Of	and,mediate
R15333	T22668	T22667	arg2Of	RIP3,and
R15334	T22669	T22664	arg2Of	mediate,shown
R15335	T22669	T22665	arg1Of	mediate,that
R15336	T22672	T22669	arg2Of	damage,mediate
R15337	T22672	T22670	arg1Of	damage,the
R15338	T22672	T22671	arg1Of	damage,cellular
R15339	T22672	T22673	arg2Of	damage,introduced
R15340	T22676	T22673	arg1Of	SIRS,introduced
R15341	T22676	T22674	arg2Of	SIRS,by
R15342	T22676	T22675	arg1Of	SIRS,TNF-induced
R15343	T22676	T22677	arg1Of	SIRS,[
R15344	T22678	T22677	arg2Of	6,[
R15345	T22679	T22677	arg3Of	],[
R15346	T22681	T22680	arg1Of	role,The
R15347	T22681	T22682	arg1Of	role,of
R15348	T22681	T22685	arg1Of	role,in
R15349	T22681	T22691	arg1Of	role,warrants
R15350	T22684	T22682	arg2Of	kinase,of
R15351	T22684	T22683	arg1Of	kinase,RIP1
R15352	T22686	T22687	arg1Of	acute,and
R15353	T22688	T22687	arg2Of	chronic,and
R15354	T22690	T22685	arg2Of	diseases,in
R15355	T22690	T22686	arg1Of	diseases,acute
R15356	T22690	T22688	arg1Of	diseases,chronic
R15357	T22690	T22689	arg1Of	diseases,inflammatory
R15358	T22691	T22694	arg1Of	warrants,","
R15359	T22691	T22695	arg1Of	warrants,as
R15360	T22693	T22691	arg2Of	investigation,warrants
R15361	T22693	T22692	arg1Of	investigation,further
R15362	T22696	T22697	arg1Of	efficient,and
R15363	T22698	T22697	arg2Of	specific,and
R15364	T22701	T22696	arg1Of	inhibitors,efficient
R15365	T22701	T22698	arg1Of	inhibitors,specific
R15366	T22701	T22699	arg1Of	inhibitors,RIP1
R15367	T22701	T22700	arg1Of	inhibitors,kinase
R15368	T22701	T22702	arg1Of	inhibitors,may
R15369	T22701	T22703	arg1Of	inhibitors,offer
R15370	T22703	T22695	arg2Of	offer,as
R15371	T22703	T22702	arg2Of	offer,may
R15372	T22705	T22703	arg2Of	benefit,offer
R15373	T22705	T22704	arg1Of	benefit,therapeutic
R15374	T22705	T22706	arg1Of	benefit,for
R15375	T22707	T22706	arg2Of	treating,for
R15376	T22709	T22707	arg2Of	conditions,treating
R15377	T22709	T22708	arg1Of	conditions,these
R14461	T21814	T21827	arg1Of	warrants,","
R14462	T21814	T21828	arg1Of	warrants,since
R14463	T21816	T21815	arg1Of	re-evaluation,a
R14464	T21816	T21817	arg1Of	re-evaluation,of
R14465	T21816	T21824	arg1Of	re-evaluation,in
R14467	T21819	T21817	arg2Of	roles,of
R14468	T21819	T21818	arg1Of	roles,the
R14469	T21819	T21820	arg1Of	roles,of
R14470	T21823	T21820	arg2Of	substrates,of
R14471	T21823	T21821	arg1Of	substrates,additional
R14472	T21823	T21822	arg1Of	substrates,Akt
R14473	T21826	T21824	arg2Of	death,in
R14474	T21826	T21825	arg1Of	death,necroptotic
R14475	T21831	T21829	arg1Of	connections,no
R14476	T21831	T21830	arg1Of	connections,such
R14477	T21831	T21832	arg1Of	connections,have
R14478	T21831	T21833	arg1Of	connections,been
R14479	T21831	T21834	arg2Of	connections,established
R14480	T21834	T21828	arg2Of	established,since
R14481	T21834	T21832	arg2Of	established,have
R14482	T21834	T21833	arg2Of	established,been
R14483	T21838	T21837	arg1Of	mechanisms,the
R14484	T21838	T21839	arg1Of	mechanisms,connecting
R14488	T21840	T21839	arg2Of	mTORC1,connecting
R14489	T21840	T21841	arg1Of	mTORC1,to
R14490	T21842	T21841	arg2Of	JNK,to
R14491	T21843	T21835	arg1Of	remain,Similarly
R14492	T21843	T21836	arg1Of	remain,","

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T21051	1901-1905	Antecedent	denotes	PDK1
T21050	1945-1962	Anaphor	denotes	these two kinases
R13989	T21050	T21051	boundBy	these two kinases,PDK1

bionlp-st-ge-2016-test-proteins

Id	Subject	Object	Predicate	Lexical cue
T21083	7342-7346	Protein	denotes	RIP1
T21082	7098-7102	Protein	denotes	RIP1
T21081	7080-7084	Protein	denotes	TNFα
T21080	6314-6318	Protein	denotes	TNFα
T21079	6254-6258	Protein	denotes	RIP1
T21078	6093-6097	Protein	denotes	TNFα
T21077	5986-5990	Protein	denotes	FADD
T21076	5736-5740	Protein	denotes	RIP1
T21075	5372-5376	Protein	denotes	TNFα
T21074	5244-5248	Protein	denotes	TNFα
T21073	4578-4582	Protein	denotes	RIP1
T21072	4073-4077	Protein	denotes	MDM2
T21071	4066-4067	Protein	denotes	4
T21070	4060-4065	Protein	denotes	FoxO1
T21069	3849-3853	Protein	denotes	RIP1
T21068	3523-3527	Protein	denotes	TNFα
T21067	3376-3380	Protein	denotes	TNFα
T21066	2650-2654	Protein	denotes	TNFα
T21065	2487-2491	Protein	denotes	RIP1
T21064	2155-2162	Protein	denotes	Myr-Akt
T21063	2038-2042	Protein	denotes	RIP1
T21062	1901-1905	Protein	denotes	PDK1
T21061	1879-1883	Protein	denotes	RIP1
T21060	1508-1512	Protein	denotes	RIP1
T21059	1429-1433	Protein	denotes	RIP1
T21058	850-854	Protein	denotes	RIP1
T21057	824-828	Protein	denotes	TNFα
T21056	730-737	Protein	denotes	Myr-Akt
T21055	662-669	Protein	denotes	Myr-Akt
T21054	387-391	Protein	denotes	TNFα
T21053	260-264	Protein	denotes	RIP1
T21052	116-120	Protein	denotes	RIP1
T21092	8178-8182	Protein	denotes	RIP1
T21091	8065-8069	Protein	denotes	RIP1
T21090	7984-7988	Protein	denotes	RIP3
T21089	7975-7979	Protein	denotes	RIP1
T21088	7630-7634	Protein	denotes	TNFα
T21087	7462-7466	Protein	denotes	TNFα
T21086	7382-7391	Protein	denotes	caspase-8
T21085	7373-7377	Protein	denotes	FADD
T21084	7347-7351	Protein	denotes	RIP3

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T22951	5312-5316	http://www.uniprot.org/uniprot/P42345	denotes	mTOR
T22950	4863-4867	http://www.uniprot.org/uniprot/P42345	denotes	mTOR
T22949	4060-4065	http://www.uniprot.org/uniprot/Q12778	denotes	FoxO1
T22948	3263-3265	http://www.uniprot.org/uniprot/P03372	denotes	ER
T22947	8031-8034	http://www.uniprot.org/uniprot/P01375	denotes	TNF
T22946	7630-7634	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22945	7462-7466	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22944	7080-7084	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22943	6314-6318	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22942	6093-6097	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22941	5372-5376	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22940	5244-5248	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22939	3523-3527	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22938	3376-3380	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22937	2650-2654	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22936	824-828	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22935	387-391	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T22934	8178-8182	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22933	8065-8069	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22932	7975-7979	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22931	7342-7346	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22930	7098-7102	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22929	6254-6258	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22928	5736-5740	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22927	4578-4582	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22926	3849-3853	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22925	2487-2491	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22924	2038-2042	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22923	1879-1883	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22922	1508-1512	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22921	1429-1433	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22920	850-854	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22919	260-264	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22918	116-120	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T22917	7103-7106	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22916	6441-6444	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22915	6032-6035	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22914	5761-5764	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22913	5687-5690	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22912	5305-5308	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22911	4789-4792	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22910	4771-4774	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22909	4532-4535	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22908	4336-4339	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22875	4532-4535	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22874	4336-4339	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22873	4144-4147	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22872	4006-4009	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22871	3933-3936	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22870	3842-3845	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22869	3010-3013	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22868	2911-2914	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22867	2714-2717	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22866	2614-2617	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22865	2480-2483	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22864	2305-2308	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22863	2159-2162	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22862	2019-2022	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22861	1907-1910	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22860	1456-1459	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22859	1369-1372	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22858	1142-1145	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22857	1019-1022	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22856	920-923	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22855	734-737	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22854	666-669	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22844	5305-5308	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22843	4789-4792	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22842	4771-4774	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22841	4532-4535	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22840	4336-4339	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22839	4144-4147	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22838	4006-4009	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22837	3933-3936	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22836	3842-3845	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22835	3010-3013	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22834	2911-2914	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22833	2714-2717	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22832	2614-2617	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22831	2480-2483	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22830	2305-2308	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22829	2159-2162	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22828	2019-2022	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22827	1907-1910	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22826	1456-1459	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22825	1369-1372	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22824	1142-1145	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22823	1019-1022	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22822	920-923	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22821	734-737	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22820	666-669	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22819	603-606	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22818	470-473	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22817	197-200	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22816	48-51	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22907	4144-4147	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22906	4006-4009	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22905	3933-3936	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22904	3842-3845	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22903	3010-3013	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22902	2911-2914	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22901	2714-2717	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22900	2614-2617	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22899	2480-2483	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22898	2305-2308	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22897	2159-2162	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22896	2019-2022	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22895	1907-1910	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22888	666-669	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22887	603-606	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22886	470-473	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22885	197-200	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22884	48-51	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22883	7103-7106	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22882	6441-6444	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22881	6032-6035	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22880	5761-5764	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22879	5687-5690	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22878	5305-5308	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22877	4789-4792	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22876	4771-4774	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22853	603-606	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22852	470-473	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22851	197-200	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22850	48-51	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T22849	7103-7106	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22848	6441-6444	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22847	6032-6035	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22846	5761-5764	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22845	5687-5690	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T22894	1456-1459	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22893	1369-1372	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22892	1142-1145	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22891	1019-1022	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22890	920-923	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T22889	734-737	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T20933	7870-7875	http://purl.obolibrary.org/obo/UBERON_0000062	denotes	organ
T20932	7511-7521	http://purl.obolibrary.org/obo/UBERON_0000160	denotes	intestinal
T20931	5968-5972	http://purl.obolibrary.org/obo/UBERON_0002048	denotes	lung

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T21263	7496-7521	http://purl.obolibrary.org/obo/GO_0048565	denotes	development of intestinal
T21262	7496-7507	http://purl.obolibrary.org/obo/GO_0032502	denotes	development
T21261	7352-7369	http://purl.obolibrary.org/obo/GO_0016301	denotes	kinase activities
T21260	8001-8009	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T21259	6860-6868	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T21258	7791-7803	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T21257	7522-7534	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T21256	6788-6800	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T21255	6563-6575	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T21254	7817-7836	http://purl.obolibrary.org/obo/GO_0097300	denotes	necrotic cell death
T21253	6953-6972	http://purl.obolibrary.org/obo/GO_0097300	denotes	necrotic cell death
T21252	6621-6640	http://purl.obolibrary.org/obo/GO_0097300	denotes	necrotic cell death
T21251	6521-6539	http://purl.obolibrary.org/obo/GO_0097300	denotes	regulated necrosis
T21250	5661-5683	http://purl.obolibrary.org/obo/GO_0060544	denotes	regulation necroptosis
T21249	4886-4909	http://purl.obolibrary.org/obo/GO_0048102	denotes	autophagy in cell death
T21248	5583-5592	http://purl.obolibrary.org/obo/GO_0006914	denotes	autophagy
T21247	5292-5301	http://purl.obolibrary.org/obo/GO_0006914	denotes	autophagy
T21246	5210-5219	http://purl.obolibrary.org/obo/GO_0006914	denotes	autophagy
T21245	5053-5062	http://purl.obolibrary.org/obo/GO_0006914	denotes	autophagy
T21244	4886-4895	http://purl.obolibrary.org/obo/GO_0006914	denotes	autophagy
T21243	4831-4840	http://purl.obolibrary.org/obo/GO_0006914	denotes	autophagy
T21242	4778-4787	http://purl.obolibrary.org/obo/GO_0006914	denotes	autophagy
T21241	4743-4767	http://purl.obolibrary.org/obo/GO_1901214	denotes	regulation of cell death
T21240	7817-7836	http://purl.obolibrary.org/obo/GO_0010939	denotes	necrotic cell death
T21239	6953-6972	http://purl.obolibrary.org/obo/GO_0010939	denotes	necrotic cell death
T21238	6621-6640	http://purl.obolibrary.org/obo/GO_0010939	denotes	necrotic cell death
T21237	4743-4767	http://purl.obolibrary.org/obo/GO_0010939	denotes	regulation of cell death
T21236	4743-4767	http://purl.obolibrary.org/obo/GO_1904092	denotes	regulation of cell death
T21235	4743-4767	http://purl.obolibrary.org/obo/GO_0060548	denotes	regulation of cell death
T21234	4743-4767	http://purl.obolibrary.org/obo/GO_0010942	denotes	regulation of cell death
T21233	4743-4767	http://purl.obolibrary.org/obo/GO_0010941	denotes	regulation of cell death
T21232	4743-4767	http://purl.obolibrary.org/obo/GO_0043067	denotes	regulation of cell death
T21231	5570-5582	http://purl.obolibrary.org/obo/GO_0043066	denotes	pro-survival
T21230	4313-4325	http://purl.obolibrary.org/obo/GO_0043066	denotes	pro-survival
T21229	4169-4181	http://purl.obolibrary.org/obo/GO_0043066	denotes	pro-survival
T21228	4053-4056	http://purl.obolibrary.org/obo/GO_0050321	denotes	GSK
T21227	7817-7836	http://purl.obolibrary.org/obo/GO_0070265	denotes	necrotic cell death
T21226	6953-6972	http://purl.obolibrary.org/obo/GO_0070265	denotes	necrotic cell death
T21225	6621-6640	http://purl.obolibrary.org/obo/GO_0070265	denotes	necrotic cell death
T21224	6531-6539	http://purl.obolibrary.org/obo/GO_0070265	denotes	necrosis
T21223	3810-3818	http://purl.obolibrary.org/obo/GO_0070265	denotes	necrosis
T21222	6531-6539	http://purl.obolibrary.org/obo/GO_0019835	denotes	necrosis
T21221	3810-3818	http://purl.obolibrary.org/obo/GO_0019835	denotes	necrosis
T21220	6531-6539	http://purl.obolibrary.org/obo/GO_0001906	denotes	necrosis
T21219	3810-3818	http://purl.obolibrary.org/obo/GO_0001906	denotes	necrosis
T21218	4398-4407	http://purl.obolibrary.org/obo/GO_0097194	denotes	apoptosis
T21217	3610-3619	http://purl.obolibrary.org/obo/GO_0097194	denotes	apoptosis
T21216	4438-4458	http://purl.obolibrary.org/obo/GO_0006915	denotes	apoptotic cell death
T21215	4398-4407	http://purl.obolibrary.org/obo/GO_0006915	denotes	apoptosis
T21214	3610-3619	http://purl.obolibrary.org/obo/GO_0006915	denotes	apoptosis
T21213	3508-3519	http://purl.obolibrary.org/obo/GO_0006412	denotes	translation
T21212	1901-1905	http://purl.obolibrary.org/obo/GO_0004740	denotes	PDK1
T21211	1755-1784	http://purl.obolibrary.org/obo/GO_0042327	denotes	phosphorylation or activation
T21210	1531-1542	http://purl.obolibrary.org/obo/GO_0016791	denotes	phosphatase
T21209	8183-8200	http://purl.obolibrary.org/obo/GO_0033673	denotes	kinase inhibitors
T21208	1513-1528	http://purl.obolibrary.org/obo/GO_0033673	denotes	kinase inhibits
T21207	5661-5671	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T21206	4743-4753	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T21205	3949-3959	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T21204	3828-3838	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T21203	3229-3239	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T21202	2563-2573	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T21201	1355-1365	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T21200	587-599	http://purl.obolibrary.org/obo/GO_0051179	denotes	localization
T21199	578-599	http://purl.obolibrary.org/obo/GO_0051668	denotes	membrane localization
T21198	571-599	http://purl.obolibrary.org/obo/GO_0072659	denotes	plasma membrane localization
T21197	571-599	http://purl.obolibrary.org/obo/GO_0044856	denotes	plasma membrane localization
T21196	542-548	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T21195	7896-7901	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21194	7831-7836	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21193	6967-6972	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21192	6635-6640	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21191	6126-6131	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21190	5560-5565	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21189	5478-5483	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21188	4904-4909	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21187	4762-4767	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21186	4500-4505	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21185	4453-4458	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21184	4239-4244	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21183	3700-3705	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21182	3040-3045	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21181	2640-2645	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21180	1268-1273	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21179	420-425	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T21178	6531-6539	http://purl.obolibrary.org/obo/GO_0008219	denotes	necrosis
T21177	3810-3818	http://purl.obolibrary.org/obo/GO_0008219	denotes	necrosis
T21176	6962-6972	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T21175	6630-6640	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T21174	6121-6131	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T21173	4899-4909	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T21172	4757-4767	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T21171	4448-4458	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T21170	4234-4244	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T21169	3695-3705	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T21168	1263-1273	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T21167	415-425	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T21166	7085-7094	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T21165	6098-6107	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T21164	2655-2664	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T21163	829-838	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T21162	392-401	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T21161	3572-3575	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21160	3369-3372	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21159	3243-3246	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21158	3143-3146	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21157	816-819	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21156	361-364	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21155	7642-7653	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21154	7446-7457	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21153	7034-7045	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21152	6832-6843	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21151	6675-6686	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21150	6241-6252	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21149	5672-5683	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21148	5349-5360	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21147	5229-5240	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21146	5072-5083	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21145	4973-4984	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21144	3901-3912	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21143	3445-3456	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21142	3307-3318	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21141	2207-2218	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21140	1788-1799	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21139	1380-1391	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21138	1199-1210	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21137	777-788	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21136	324-335	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T21135	7817-7836	http://purl.obolibrary.org/obo/GO_0070266	denotes	necrotic cell death
T21134	6953-6972	http://purl.obolibrary.org/obo/GO_0070266	denotes	necrotic cell death
T21133	6621-6640	http://purl.obolibrary.org/obo/GO_0070266	denotes	necrotic cell death
T21132	1774-1799	http://purl.obolibrary.org/obo/GO_0070266	denotes	activation of necroptosis
T21131	764-788	http://purl.obolibrary.org/obo/GO_0070266	denotes	induction of necroptosis
T21130	7446-7457	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21129	7034-7045	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21128	6832-6843	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21127	6675-6686	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21126	6241-6252	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21125	5672-5683	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21124	5349-5360	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21123	5229-5240	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21122	5072-5083	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21121	4973-4984	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21120	3901-3912	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21119	3445-3456	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21118	3307-3318	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21117	2207-2218	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21116	1788-1799	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21115	1380-1391	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21114	1199-1210	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21113	777-788	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21112	324-335	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T21111	2461-2476	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T21110	2257-2272	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T21109	2000-2015	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T21108	1755-1770	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T21107	1467-1482	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T21106	990-1005	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T21105	901-916	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T21104	451-466	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T21103	201-216	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T21102	7223-7232	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T21101	6471-6480	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T21100	6380-6389	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T21099	6036-6045	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T21098	5801-5810	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T21097	5748-5757	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T21096	4182-4191	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T21095	967-976	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T21094	286-295	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T21093	90-99	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T21277	7352-7369	http://purl.obolibrary.org/obo/GO_0016301	denotes	kinase activities
T21276	4053-4056	http://purl.obolibrary.org/obo/GO_0050321	denotes	GSK
T21275	2398-2406	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibody
T21274	1901-1905	http://purl.obolibrary.org/obo/GO_0004740	denotes	PDK1
T21273	1531-1542	http://purl.obolibrary.org/obo/GO_0016791	denotes	phosphatase
T21272	3572-3575	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21271	3369-3372	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21270	3243-3246	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21269	3143-3146	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21268	816-819	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T21267	361-364	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T21293	1177-1183	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T21292	6915-6923	http://purl.obolibrary.org/obo/GO_0016020	denotes	membrane
T21291	644-652	http://purl.obolibrary.org/obo/GO_0016020	denotes	membrane
T21290	578-586	http://purl.obolibrary.org/obo/GO_0016020	denotes	membrane
T21289	6908-6923	http://purl.obolibrary.org/obo/GO_0005886	denotes	plasma membrane
T21288	571-586	http://purl.obolibrary.org/obo/GO_0005886	denotes	plasma membrane
T21281	2317-2322	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T21280	1808-1813	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T21279	1107-1112	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T21278	344-349	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T21303	3263-3265	http://purl.obolibrary.org/obo/GO_0005783	denotes	ER
T21302	2398-2406	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibody
T21301	2398-2406	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibody
T21300	4028-4034	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T21299	3482-3488	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T21298	3403-3409	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T21297	3212-3218	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T21296	3133-3139	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T21295	2838-2844	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T21294	2748-2754	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T21287	7826-7830	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T21286	7406-7411	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T21285	6164-6169	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T21284	6008-6013	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T21283	5606-5611	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T21282	5112-5117	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

sentences

Id	Subject	Object	Predicate	Lexical cue
T20982	8053-8261	Sentence	denotes	The role of RIP1 kinase in acute and chronic inflammatory diseases warrants further investigation, as efficient and specific RIP1 kinase inhibitors may offer therapeutic benefit for treating these conditions.
T20981	7903-8052	Sentence	denotes	Along these lines, another recent paper by Duprez et al. has shown that RIP1 and RIP3 mediate the cellular damage introduced by TNF-induced SIRS [6].
T20980	7601-7902	Sentence	denotes	This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death.
T20979	7287-7600	Sentence	denotes	Two recent papers showed that the loss of control over RIP1/RIP3 kinase activities by FADD and caspase-8 in epithelial cells unleashes a feed forward cycle of necroptosis and TNFα production, resulting in the development of intestinal inflammation in mice and, possibly, in patients with Crohn’s disease [4], [5].
T20978	7234-7286	Sentence	denotes	Initial in vivo data appears to support this notion.
T20977	7116-7233	Sentence	denotes	Therefore, this pathway may represent a new molecular target for the inhibition of pathologic inflammatory signaling.
T20976	6741-7115	Sentence	denotes	Our results highlight an important notion that inflammation not only passively accompanies necroptosis in a variety of cellular systems by the virtue of rapid loss of plasma membrane integrity characteristic for necrotic cell death, but also that it is an intrinsic and regulated component of necroptosis due to the specific activation of TNFα synthesis by RIP1/Akt kinases.
T20975	6556-6740	Sentence	denotes	Robust inflammation is one of the most important consequences of necrotic cell death as well as its regulated subtype, necroptosis, both in vitro and in vivo [1], [5], [6], [50], [51].
T20974	6320-6555	Sentence	denotes	These data emphasize the emerging complexity of necroptotic signaling mechanisms and highlight the major contribution of Akt to increased inflammatory signaling, specifically accompanying this form of regulated necrosis [5], [6], [10].
T20973	6171-6319	Sentence	denotes	A recent study [15] has demonstrated that, in addition to its role in necroptosis, RIP1 plays an important role in mediating the production of TNFα.
T20972	5946-6170	Sentence	denotes	Importantly, in mouse lung fibroblasts, FADD-deficient Jurkat cells, and macrophages, Akt signaling contributed more prominently to an increase in TNFα synthesis, rather than cell death per se, unlike its role in L929 cells.
T20971	5852-5945	Sentence	denotes	At the same time, the significance of this connection varies in a cell type specific fashion.
T20970	5700-5851	Sentence	denotes	Importantly, our data revealed that RIP1 kinase signaling to Akt is a general feature of necroptotic signaling that is observed in multiple cell types.
T20969	5485-5699	Sentence	denotes	Clearly, further identification of the factors differentiating between pro-death and pro-survival autophagy in mammalian cells is required to better understand its role in the regulation necroptosis by Akt pathway.
T20968	5255-5484	Sentence	denotes	This suggests that the inhibition of autophagy by Akt or mTOR in our system may contribute to necroptosis induced by TNFα, however, it is more difficult to reconcile with the positive role of these proteins in zVAD-induced death.
T20967	5130-5254	Sentence	denotes	Others, including ourselves in unpublished data, have found that inihibition of autophagy promotes necroptosis by TNFα [49].
T20966	5008-5129	Sentence	denotes	Several studies suggested that activation of autophagy promotes necroptosis induced by zVAD.fmk in L929 cells [11], [14].
T20965	4874-5007	Sentence	denotes	The role of autophagy in cell death in general is very complex and it can both promote and inhibit necroptosis in various situations.
T20964	4789-4873	Sentence	denotes	Akt activation leads to the inhibition of autophagy through activation of mTOR [48].
T20963	4675-4788	Sentence	denotes	Another mechanism that should be considered in conjunction with the regulation of cell death by Akt is autophagy.
T20962	4460-4674	Sentence	denotes	The final decision between survival and death may depend on additional, Akt-independent inputs, such as the status of RIP1 kinase, expression of particular oncogenic factors [45] or excessive metabolic stress [47].
T20961	4246-4459	Sentence	denotes	It is tempting to speculate that rather than serving a universally pro-survival role, the Akt pathway may function to promote cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death.
T20960	4079-4245	Sentence	denotes	Therefore, it may no longer be safe to assume that activation of Akt universally reflects pro-survival signaling nor that its inhibition will lead to more cell death.
T20959	3862-4078	Sentence	denotes	Importantly, while it is possible that necroptosis-specific targets of Akt exist, this regulation clearly involves a number of well established Akt targets including mTORC1, and potentially, GSK-3, FoxO1/4, and MDM2.
T20958	3774-3861	Sentence	denotes	Our data demonstrates a new mode of necrosis-specific regulation of Akt by RIP1 kinase.
T20957	3577-3773	Sentence	denotes	Akt’s role as a key inhibitor of apoptosis is well documented, however, evidence of its contribution as a mediator of cell death under various circumstances has begun to emerge as well [45], [47].
T20956	3345-3576	Sentence	denotes	Given the activation of JNK by TNFα and the importance of mTORC1-dependent translational control in necroptosis, one possibility is that mTORC1 contributes to the translation of TNFα and forms a positive feed forward loop with JNK.
T20955	3172-3344	Sentence	denotes	While there are some recent examples of mTORC1-dependent regulation of JNK, e.g. following ER stress [46], the exact mechanisms during necroptosis remain to be established.
T20954	3096-3171	Sentence	denotes	Similarly, the mechanisms connecting mTORC1 to JNK remain to be elucidated.
T20953	2953-3095	Sentence	denotes	This warrants a re-evaluation of the roles of additional Akt substrates in necroptotic death, since no such connections have been established.
T20952	2779-2952	Sentence	denotes	On the other hand, we have observed only modest changes in mTORC1 activity under necroptotic conditions, suggesting that additional Akt substrates are likely to be involved.
T20951	2666-2778	Sentence	denotes	On the one hand, our data suggest new roles for Akt effector pathways mediated by mTORC1 in necroptotic control.
T20950	2575-2665	Sentence	denotes	Second, what are the key substrates of Akt that promote necrotic death and TNFα synthesis?
T20949	2220-2574	Sentence	denotes	However, we were not able to confirm phosphorylation of these residues on endogenous Akt in L929 cells using either mass spectrometry or western blotting with a phospho-specific antibody raised against Thr435 peptide, suggesting that direct phosphorylation of Akt by RIP1 likely represents an in vitro artifact and does not reflect endogenous regulation.
T20948	2108-2219	Sentence	denotes	Furthermore, mutating these residues to Ala in Myr-Akt leads to the loss of its ability to promote necroptosis.
T20947	1973-2107	Sentence	denotes	Interestingly, we observed phosphorylation of Akt by recombinant RIP1 kinase in vitro on Thr146, 195/197, and 435 and Ser381 residues.
T20946	1815-1972	Sentence	denotes	Another possibility is that the increase in Thr308 results from RIP1 kinase targeting PDK1, Akt or scaffolding factors that bring these two kinases together.
T20945	1669-1814	Sentence	denotes	However, we did not observe any effect of the PP2A inhibitor, okadaic acid, on Thr308 phosphorylation or activation of necroptosis in L929 cells.
T20944	1564-1668	Sentence	denotes	To our knowledge, PP2A is the only enzyme established to specifically dephosphorylate this residue [45].
T20943	1484-1563	Sentence	denotes	One possibility is that RIP1 kinase inhibits a phosphatase that targets Thr308.
T20942	1393-1483	Sentence	denotes	First, what is the mechanism of the RIP1-dependent increase in Akt Thr308 phosphorylation?
T20941	1275-1392	Sentence	denotes	Our results raise some important mechanistic questions relevant to the specific regulation of Akt during necroptosis.
T20940	978-1274	Sentence	denotes	Necroptotic phosphorylation of Thr308 of Akt is sufficient to increase its activity towards a number of known substrates in L929 cells and our data reveal that the Akt effector pathway downstream of mTORC1 contributes to necroptosis, thereby identifying a new mediator of this form of cell death.
T20939	840-977	Sentence	denotes	A second, RIP1 kinase-dependent input is required for Thr308 phosphorylation of Akt, which in turn is required for necroptotic signaling.
T20938	698-839	Sentence	denotes	At the same time, expression of Myr-Akt is not sufficient for the induction of necroptosis or efficient activation of JNK and TNFα synthesis.
T20937	505-697	Sentence	denotes	The first input, which is induced by growth factors, leads to the plasma membrane localization of Akt. Expression of constitutively active membrane-targeted Myr-Akt overcomes this requirement.
T20936	427-504	Sentence	denotes	According to our model, phosphorylation of Akt requires two distinct signals.
T20935	228-426	Sentence	denotes	This provides a link connecting RIP1 kinase to downstream signaling and execution events during necroptosis in L929 cells, including JNK activation, autocrine TNFα synthesis and eventual cell death.
T20934	11-227	Sentence	denotes	Altogether, our results suggest that Akt kinase is specifically engaged in the signaling downstream from RIP1 kinase, which exerts its activity through promoting a selective increase in Akt phosphorylation on Thr308.
T257	0-10	Sentence	denotes	Discussion
T258	11-227	Sentence	denotes	Altogether, our results suggest that Akt kinase is specifically engaged in the signaling downstream from RIP1 kinase, which exerts its activity through promoting a selective increase in Akt phosphorylation on Thr308.
T259	228-426	Sentence	denotes	This provides a link connecting RIP1 kinase to downstream signaling and execution events during necroptosis in L929 cells, including JNK activation, autocrine TNFα synthesis and eventual cell death.
T260	427-504	Sentence	denotes	According to our model, phosphorylation of Akt requires two distinct signals.
T261	505-607	Sentence	denotes	The first input, which is induced by growth factors, leads to the plasma membrane localization of Akt.
T262	608-697	Sentence	denotes	Expression of constitutively active membrane-targeted Myr-Akt overcomes this requirement.
T263	698-839	Sentence	denotes	At the same time, expression of Myr-Akt is not sufficient for the induction of necroptosis or efficient activation of JNK and TNFα synthesis.
T264	840-977	Sentence	denotes	A second, RIP1 kinase-dependent input is required for Thr308 phosphorylation of Akt, which in turn is required for necroptotic signaling.
T265	978-1274	Sentence	denotes	Necroptotic phosphorylation of Thr308 of Akt is sufficient to increase its activity towards a number of known substrates in L929 cells and our data reveal that the Akt effector pathway downstream of mTORC1 contributes to necroptosis, thereby identifying a new mediator of this form of cell death.
T266	1275-1392	Sentence	denotes	Our results raise some important mechanistic questions relevant to the specific regulation of Akt during necroptosis.
T267	1393-1483	Sentence	denotes	First, what is the mechanism of the RIP1-dependent increase in Akt Thr308 phosphorylation?
T268	1484-1563	Sentence	denotes	One possibility is that RIP1 kinase inhibits a phosphatase that targets Thr308.
T269	1564-1668	Sentence	denotes	To our knowledge, PP2A is the only enzyme established to specifically dephosphorylate this residue [45].
T270	1669-1814	Sentence	denotes	However, we did not observe any effect of the PP2A inhibitor, okadaic acid, on Thr308 phosphorylation or activation of necroptosis in L929 cells.
T271	1815-1972	Sentence	denotes	Another possibility is that the increase in Thr308 results from RIP1 kinase targeting PDK1, Akt or scaffolding factors that bring these two kinases together.
T272	1973-2107	Sentence	denotes	Interestingly, we observed phosphorylation of Akt by recombinant RIP1 kinase in vitro on Thr146, 195/197, and 435 and Ser381 residues.
T273	2108-2219	Sentence	denotes	Furthermore, mutating these residues to Ala in Myr-Akt leads to the loss of its ability to promote necroptosis.
T274	2220-2574	Sentence	denotes	However, we were not able to confirm phosphorylation of these residues on endogenous Akt in L929 cells using either mass spectrometry or western blotting with a phospho-specific antibody raised against Thr435 peptide, suggesting that direct phosphorylation of Akt by RIP1 likely represents an in vitro artifact and does not reflect endogenous regulation.
T275	2575-2665	Sentence	denotes	Second, what are the key substrates of Akt that promote necrotic death and TNFα synthesis?
T276	2666-2778	Sentence	denotes	On the one hand, our data suggest new roles for Akt effector pathways mediated by mTORC1 in necroptotic control.
T277	2779-2952	Sentence	denotes	On the other hand, we have observed only modest changes in mTORC1 activity under necroptotic conditions, suggesting that additional Akt substrates are likely to be involved.
T278	2953-3095	Sentence	denotes	This warrants a re-evaluation of the roles of additional Akt substrates in necroptotic death, since no such connections have been established.
T279	3096-3171	Sentence	denotes	Similarly, the mechanisms connecting mTORC1 to JNK remain to be elucidated.
T280	3172-3344	Sentence	denotes	While there are some recent examples of mTORC1-dependent regulation of JNK, e.g. following ER stress [46], the exact mechanisms during necroptosis remain to be established.
T281	3345-3576	Sentence	denotes	Given the activation of JNK by TNFα and the importance of mTORC1-dependent translational control in necroptosis, one possibility is that mTORC1 contributes to the translation of TNFα and forms a positive feed forward loop with JNK.
T282	3577-3773	Sentence	denotes	Akt’s role as a key inhibitor of apoptosis is well documented, however, evidence of its contribution as a mediator of cell death under various circumstances has begun to emerge as well [45], [47].
T283	3774-3861	Sentence	denotes	Our data demonstrates a new mode of necrosis-specific regulation of Akt by RIP1 kinase.
T284	3862-4078	Sentence	denotes	Importantly, while it is possible that necroptosis-specific targets of Akt exist, this regulation clearly involves a number of well established Akt targets including mTORC1, and potentially, GSK-3, FoxO1/4, and MDM2.
T285	4079-4245	Sentence	denotes	Therefore, it may no longer be safe to assume that activation of Akt universally reflects pro-survival signaling nor that its inhibition will lead to more cell death.
T286	4246-4459	Sentence	denotes	It is tempting to speculate that rather than serving a universally pro-survival role, the Akt pathway may function to promote cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death.
T287	4460-4674	Sentence	denotes	The final decision between survival and death may depend on additional, Akt-independent inputs, such as the status of RIP1 kinase, expression of particular oncogenic factors [45] or excessive metabolic stress [47].
T288	4675-4788	Sentence	denotes	Another mechanism that should be considered in conjunction with the regulation of cell death by Akt is autophagy.
T289	4789-4873	Sentence	denotes	Akt activation leads to the inhibition of autophagy through activation of mTOR [48].
T290	4874-5007	Sentence	denotes	The role of autophagy in cell death in general is very complex and it can both promote and inhibit necroptosis in various situations.
T291	5008-5129	Sentence	denotes	Several studies suggested that activation of autophagy promotes necroptosis induced by zVAD.fmk in L929 cells [11], [14].
T292	5130-5254	Sentence	denotes	Others, including ourselves in unpublished data, have found that inihibition of autophagy promotes necroptosis by TNFα [49].
T293	5255-5484	Sentence	denotes	This suggests that the inhibition of autophagy by Akt or mTOR in our system may contribute to necroptosis induced by TNFα, however, it is more difficult to reconcile with the positive role of these proteins in zVAD-induced death.
T294	5485-5699	Sentence	denotes	Clearly, further identification of the factors differentiating between pro-death and pro-survival autophagy in mammalian cells is required to better understand its role in the regulation necroptosis by Akt pathway.
T295	5700-5851	Sentence	denotes	Importantly, our data revealed that RIP1 kinase signaling to Akt is a general feature of necroptotic signaling that is observed in multiple cell types.
T296	5852-5945	Sentence	denotes	At the same time, the significance of this connection varies in a cell type specific fashion.
T297	5946-6170	Sentence	denotes	Importantly, in mouse lung fibroblasts, FADD-deficient Jurkat cells, and macrophages, Akt signaling contributed more prominently to an increase in TNFα synthesis, rather than cell death per se, unlike its role in L929 cells.
T298	6171-6319	Sentence	denotes	A recent study [15] has demonstrated that, in addition to its role in necroptosis, RIP1 plays an important role in mediating the production of TNFα.
T299	6320-6555	Sentence	denotes	These data emphasize the emerging complexity of necroptotic signaling mechanisms and highlight the major contribution of Akt to increased inflammatory signaling, specifically accompanying this form of regulated necrosis [5], [6], [10].
T300	6556-6740	Sentence	denotes	Robust inflammation is one of the most important consequences of necrotic cell death as well as its regulated subtype, necroptosis, both in vitro and in vivo [1], [5], [6], [50], [51].
T301	6741-7115	Sentence	denotes	Our results highlight an important notion that inflammation not only passively accompanies necroptosis in a variety of cellular systems by the virtue of rapid loss of plasma membrane integrity characteristic for necrotic cell death, but also that it is an intrinsic and regulated component of necroptosis due to the specific activation of TNFα synthesis by RIP1/Akt kinases.
T302	7116-7233	Sentence	denotes	Therefore, this pathway may represent a new molecular target for the inhibition of pathologic inflammatory signaling.
T303	7234-7286	Sentence	denotes	Initial in vivo data appears to support this notion.
T304	7287-7600	Sentence	denotes	Two recent papers showed that the loss of control over RIP1/RIP3 kinase activities by FADD and caspase-8 in epithelial cells unleashes a feed forward cycle of necroptosis and TNFα production, resulting in the development of intestinal inflammation in mice and, possibly, in patients with Crohn’s disease [4], [5].
T305	7601-7902	Sentence	denotes	This increased production of TNFα during necroptosis may also be important for acute necrotizing diseases, such as necrotizing pancreatitis and acute bacterial infections, where hyper-acute inflammation accompanying necrotic cell death is the primary cause of multiple organ failure and patient death.
T306	7903-8052	Sentence	denotes	Along these lines, another recent paper by Duprez et al. has shown that RIP1 and RIP3 mediate the cellular damage introduced by TNF-induced SIRS [6].
T307	8053-8261	Sentence	denotes	The role of RIP1 kinase in acute and chronic inflammatory diseases warrants further investigation, as efficient and specific RIP1 kinase inhibitors may offer therapeutic benefit for treating these conditions.

ICD10

Id	Subject	Object	Predicate	Lexical cue
T21266	7751-7771	http://purl.bioontology.org/ontology/ICD10/A49.9	denotes	bacterial infections
T21265	7728-7750	http://purl.bioontology.org/ontology/ICD10/K85	denotes	pancreatitis and acute
T21264	7575-7590	http://purl.bioontology.org/ontology/ICD10/K50.9	denotes	Crohn’s disease

simple1

Id	Subject	Object	Predicate	Lexical cue
T21344	8178-8182	Protein	denotes	RIP1
T21343	8065-8069	Protein	denotes	RIP1
T21342	7984-7988	Protein	denotes	RIP3
T21341	7975-7979	Protein	denotes	RIP1
T21340	7630-7634	Protein	denotes	TNFα
T21339	7462-7466	Protein	denotes	TNFα
T21338	7382-7391	Protein	denotes	caspase-8
T21337	7373-7377	Protein	denotes	FADD
T21336	7347-7351	Protein	denotes	RIP3
T21335	7342-7346	Protein	denotes	RIP1
T21334	7098-7102	Protein	denotes	RIP1
T21333	7080-7084	Protein	denotes	TNFα
T21332	6314-6318	Protein	denotes	TNFα
T21331	6254-6258	Protein	denotes	RIP1
T21330	6093-6097	Protein	denotes	TNFα
T21329	5986-5990	Protein	denotes	FADD
T21328	5736-5740	Protein	denotes	RIP1
T21327	5372-5376	Protein	denotes	TNFα
T21326	5244-5248	Protein	denotes	TNFα
T21325	4578-4582	Protein	denotes	RIP1
T21324	4073-4077	Protein	denotes	MDM2
T21323	4066-4067	Protein	denotes	4
T21322	4060-4065	Protein	denotes	FoxO1
T21321	3849-3853	Protein	denotes	RIP1
T21320	3523-3527	Protein	denotes	TNFα
T21319	3376-3380	Protein	denotes	TNFα
T21318	2650-2654	Protein	denotes	TNFα
T21317	2487-2491	Protein	denotes	RIP1
T21316	2155-2162	Protein	denotes	Myr-Akt
T21315	2038-2042	Protein	denotes	RIP1
T21314	1901-1905	Protein	denotes	PDK1
T21313	1879-1883	Protein	denotes	RIP1
T21312	1508-1512	Protein	denotes	RIP1
T21311	1429-1433	Protein	denotes	RIP1
T21310	850-854	Protein	denotes	RIP1
T21309	824-828	Protein	denotes	TNFα
T21308	730-737	Protein	denotes	Myr-Akt
T21307	662-669	Protein	denotes	Myr-Akt
T21306	387-391	Protein	denotes	TNFα
T21305	260-264	Protein	denotes	RIP1
T21304	116-120	Protein	denotes	RIP1

BioNLP16_DUT

Id	Subject	Object	Predicate	Lexical cue
T22778	6254-6258	Protein	denotes	RIP1
T22777	6093-6097	Protein	denotes	TNFα
T22815	8190-8200	Negative_regulation	denotes	inhibitors
T22814	7606-7615	Positive_regulation	denotes	increased
T22813	7616-7626	Gene_expression	denotes	production
T22812	7321-7325	Negative_regulation	denotes	loss
T22811	7467-7477	Gene_expression	denotes	production
T22810	7329-7336	Regulation	denotes	control
T22809	7085-7094	Gene_expression	denotes	synthesis
T22808	7066-7076	Positive_regulation	denotes	activation
T22807	6300-6310	Gene_expression	denotes	production
T22806	6286-6295	Positive_regulation	denotes	mediating
T22805	5991-6000	Negative_regulation	denotes	deficient
T22804	6098-6107	Gene_expression	denotes	synthesis
T22803	6081-6089	Positive_regulation	denotes	increase
T22802	4591-4601	Gene_expression	denotes	expression
T22801	2623-2630	Positive_regulation	denotes	promote
T22798	716-726	Gene_expression	denotes	expression
T22797	745-755	Positive_regulation	denotes	sufficient
T22796	829-838	Gene_expression	denotes	synthesis
T22795	802-812	Positive_regulation	denotes	activation
T22794	608-618	Gene_expression	denotes	Expression
T22793	644-661	Positive_regulation	denotes	membrane-targeted
T22792	392-401	Gene_expression	denotes	synthesis
T22791	8178-8182	Protein	denotes	RIP1
T22790	8065-8069	Protein	denotes	RIP1
T22789	7984-7988	Protein	denotes	RIP3
T22788	7975-7979	Protein	denotes	RIP1
T22787	7630-7634	Protein	denotes	TNFα
T22786	7462-7466	Protein	denotes	TNFα
T22785	7382-7391	Protein	denotes	caspase-8
T22784	7373-7377	Protein	denotes	FADD
T22783	7347-7351	Protein	denotes	RIP3
T22782	7342-7346	Protein	denotes	RIP1
T22781	7098-7102	Protein	denotes	RIP1
T22780	7080-7084	Protein	denotes	TNFα
T22779	6314-6318	Protein	denotes	TNFα
T22776	5986-5990	Protein	denotes	FADD
T22775	5736-5740	Protein	denotes	RIP1
T22774	5372-5376	Protein	denotes	TNFα
T22773	5244-5248	Protein	denotes	TNFα
T22772	4578-4582	Protein	denotes	RIP1
T22771	4073-4077	Protein	denotes	MDM2
T22770	4066-4067	Protein	denotes	4
T22769	4060-4065	Protein	denotes	FoxO1
T22768	3849-3853	Protein	denotes	RIP1
T22767	3523-3527	Protein	denotes	TNFα
T22766	3376-3380	Protein	denotes	TNFα
T22765	2650-2654	Protein	denotes	TNFα
T22764	2487-2491	Protein	denotes	RIP1
T22763	2155-2162	Protein	denotes	Myr-Akt
T22762	2038-2042	Protein	denotes	RIP1
T22761	1901-1905	Protein	denotes	PDK1
T22760	1879-1883	Protein	denotes	RIP1
T22759	1508-1512	Protein	denotes	RIP1
T22758	1429-1433	Protein	denotes	RIP1
T22757	850-854	Protein	denotes	RIP1
T22756	824-828	Protein	denotes	TNFα
T22755	730-737	Protein	denotes	Myr-Akt
T22754	662-669	Protein	denotes	Myr-Akt
T22753	387-391	Protein	denotes	TNFα
T22752	260-264	Protein	denotes	RIP1
T22751	116-120	Protein	denotes	RIP1
T22800	2655-2664	Gene_expression	denotes	synthesis
T22799	2461-2476	Phosphorylation	denotes	phosphorylation
R15381	T22753	T22792	themeOf	TNFα,synthesis
R15382	T22754	T22794	themeOf	Myr-Akt,Expression
R15383	T22754	T22793	themeOf	Myr-Akt,membrane-targeted
R15384	T22755	T22798	themeOf	Myr-Akt,expression
R15385	T22756	T22796	themeOf	TNFα,synthesis
R15386	T22764	T22799	themeOf	RIP1,phosphorylation
R15387	T22765	T22800	themeOf	TNFα,synthesis
R15388	T22772	T22802	themeOf	RIP1,expression
R15389	T22776	T22805	themeOf	FADD,deficient
R15390	T22777	T22804	themeOf	TNFα,synthesis
R15391	T22779	T22807	themeOf	TNFα,production
R15392	T22780	T22809	themeOf	TNFα,synthesis
R15393	T22782	T22810	themeOf	RIP1,control
R15394	T22783	T22812	themeOf	RIP3,loss
R15395	T22783	T22810	themeOf	RIP3,control
R15396	T22786	T22811	themeOf	TNFα,production
R15397	T22787	T22813	themeOf	TNFα,production
R15398	T22791	T22815	themeOf	RIP1,inhibitors
R15399	T22796	T22795	themeOf	synthesis,activation
R15400	T22798	T22797	themeOf	expression,sufficient
R15401	T22800	T22801	themeOf	synthesis,promote
R15402	T22804	T22803	themeOf	synthesis,increase
R15403	T22807	T22806	themeOf	production,mediating
R15404	T22809	T22808	themeOf	synthesis,activation
R15405	T22813	T22814	themeOf	production,increased

BioNLP16_Messiy

Id	Subject	Object	Predicate	Lexical cue
T23123	392-401	Gene_expression	denotes	synthesis
T23122	8178-8182	Protein	denotes	RIP1
T23121	8065-8069	Protein	denotes	RIP1
T23120	7984-7988	Protein	denotes	RIP3
T23119	7975-7979	Protein	denotes	RIP1
T23118	7630-7634	Protein	denotes	TNFα
T23117	7462-7466	Protein	denotes	TNFα
T23116	7382-7391	Protein	denotes	caspase-8
T23115	7373-7377	Protein	denotes	FADD
T23114	7347-7351	Protein	denotes	RIP3
T23113	7342-7346	Protein	denotes	RIP1
T23112	7098-7102	Protein	denotes	RIP1
T23111	7080-7084	Protein	denotes	TNFα
T23110	6314-6318	Protein	denotes	TNFα
T23109	6254-6258	Protein	denotes	RIP1
T23108	6093-6097	Protein	denotes	TNFα
T23107	5986-5990	Protein	denotes	FADD
T23106	5736-5740	Protein	denotes	RIP1
T23105	5372-5376	Protein	denotes	TNFα
T23104	5244-5248	Protein	denotes	TNFα
T23103	4578-4582	Protein	denotes	RIP1
T23102	4073-4077	Protein	denotes	MDM2
T23101	4066-4067	Protein	denotes	4
T23100	4060-4065	Protein	denotes	FoxO1
T23099	3849-3853	Protein	denotes	RIP1
T23098	3523-3527	Protein	denotes	TNFα
T23097	3376-3380	Protein	denotes	TNFα
T23096	2650-2654	Protein	denotes	TNFα
T23095	2487-2491	Protein	denotes	RIP1
T23094	2155-2162	Protein	denotes	Myr-Akt
T23093	2038-2042	Protein	denotes	RIP1
T23092	1901-1905	Protein	denotes	PDK1
T23091	1879-1883	Protein	denotes	RIP1
T23090	1508-1512	Protein	denotes	RIP1
T23089	1429-1433	Protein	denotes	RIP1
T23088	850-854	Protein	denotes	RIP1
T23087	824-828	Protein	denotes	TNFα
T23086	730-737	Protein	denotes	Myr-Akt
T23085	662-669	Protein	denotes	Myr-Akt
T23084	387-391	Protein	denotes	TNFα
T23083	260-264	Protein	denotes	RIP1
T23082	116-120	Protein	denotes	RIP1
T23146	8190-8200	Negative_regulation	denotes	inhibitors
T23145	7989-7996	Positive_regulation	denotes	mediate
T23144	7606-7615	Positive_regulation	denotes	increased
T23143	7616-7626	Gene_expression	denotes	production
T23142	7467-7477	Gene_expression	denotes	production
T23141	7321-7325	Negative_regulation	denotes	loss
T23140	7066-7076	Positive_regulation	denotes	activation
T23139	7085-7094	Gene_expression	denotes	synthesis
T23138	6300-6310	Gene_expression	denotes	production
T23137	6286-6295	Positive_regulation	denotes	mediating
T23136	6098-6107	Gene_expression	denotes	synthesis
T23135	5991-6000	Negative_regulation	denotes	deficient
T23134	6081-6089	Positive_regulation	denotes	increase
T23133	5361-5368	Positive_regulation	denotes	induced
T23132	2655-2664	Gene_expression	denotes	synthesis
T23131	2623-2630	Positive_regulation	denotes	promote
T23130	2461-2476	Phosphorylation	denotes	phosphorylation
T23129	855-871	Regulation	denotes	kinase-dependent
T23128	829-838	Gene_expression	denotes	synthesis
T23127	802-812	Positive_regulation	denotes	activation
T23126	716-726	Gene_expression	denotes	expression
T23125	644-661	Binding	denotes	membrane-targeted
T23124	608-618	Gene_expression	denotes	Expression
R15457	T23084	T23123	themeOf	TNFα,synthesis
R15458	T23085	T23124	themeOf	Myr-Akt,Expression
R15459	T23085	T23125	themeOf	Myr-Akt,membrane-targeted
R15463	T23095	T23130	themeOf	RIP1,phosphorylation
R15464	T23096	T23132	themeOf	TNFα,synthesis
R15465	T23105	T23133	themeOf	TNFα,induced
R15466	T23107	T23135	themeOf	FADD,deficient
R15467	T23108	T23136	themeOf	TNFα,synthesis
R15468	T23110	T23138	themeOf	TNFα,production
R15469	T23111	T23139	themeOf	TNFα,synthesis
R15470	T23114	T23141	themeOf	RIP3,loss
R15471	T23117	T23142	themeOf	TNFα,production
R15472	T23118	T23143	themeOf	TNFα,production
R15473	T23120	T23145	themeOf	RIP3,mediate
R15476	T23132	T23131	themeOf	synthesis,promote
R15477	T23136	T23134	themeOf	synthesis,increase
R15478	T23138	T23137	themeOf	production,mediating
R15479	T23139	T23140	themeOf	synthesis,activation
R15480	T23143	T23144	themeOf	production,increased
R15460	T23086	T23126	themeOf	Myr-Akt,expression
R15461	T23087	T23128	themeOf	TNFα,synthesis
R15462	T23088	T23129	themeOf	RIP1,kinase-dependent
R15474	T23122	T23146	themeOf	RIP1,inhibitors
R15475	T23128	T23127	themeOf	synthesis,activation

DLUT931

Id	Subject	Object	Predicate	Lexical cue
T23025	8190-8200	Negative_regulation	denotes	inhibitors
T23024	8057-8061	Regulation	denotes	role
T23023	7606-7615	Positive_regulation	denotes	increased
T23022	7616-7626	Gene_expression	denotes	production
T23021	7467-7477	Gene_expression	denotes	production
T23020	7321-7325	Negative_regulation	denotes	loss
T23019	7066-7076	Positive_regulation	denotes	activation
T23018	7085-7094	Gene_expression	denotes	synthesis
T23017	6286-6295	Positive_regulation	denotes	mediating
T23016	6300-6310	Gene_expression	denotes	production
T23015	6081-6089	Positive_regulation	denotes	increase
T23014	6098-6107	Gene_expression	denotes	synthesis
T23013	5991-6000	Negative_regulation	denotes	deficient
T23012	4591-4601	Gene_expression	denotes	expression
T23011	3828-3838	Regulation	denotes	regulation
T23010	3489-3500	Positive_regulation	denotes	contributes
T23009	2623-2630	Positive_regulation	denotes	promote
T23008	2655-2664	Gene_expression	denotes	synthesis
T23007	2563-2573	Regulation	denotes	regulation
T23006	2461-2476	Phosphorylation	denotes	phosphorylation
T23005	2121-2129	Negative_regulation	denotes	mutating
T23004	2000-2015	Phosphorylation	denotes	phosphorylation
T23003	1891-1900	Binding	denotes	targeting
T23002	1520-1528	Negative_regulation	denotes	inhibits
T23001	855-871	Positive_regulation	denotes	kinase-dependent
T23000	802-812	Positive_regulation	denotes	activation
T22999	829-838	Gene_expression	denotes	synthesis
T22998	745-755	Positive_regulation	denotes	sufficient
T22997	716-726	Gene_expression	denotes	expression
T22996	644-661	Positive_regulation	denotes	membrane-targeted
T22995	608-618	Gene_expression	denotes	Expression
T22994	377-386	Positive_regulation	denotes	autocrine
T22993	392-401	Gene_expression	denotes	synthesis
T22992	8178-8182	Protein	denotes	RIP1
T22991	8065-8069	Protein	denotes	RIP1
T22990	7984-7988	Protein	denotes	RIP3
T22989	7975-7979	Protein	denotes	RIP1
T22988	7630-7634	Protein	denotes	TNFα
T22987	7462-7466	Protein	denotes	TNFα
T22986	7382-7391	Protein	denotes	caspase-8
T22985	7373-7377	Protein	denotes	FADD
T22984	7347-7351	Protein	denotes	RIP3
T22983	7342-7346	Protein	denotes	RIP1
T22982	7098-7102	Protein	denotes	RIP1
T22981	7080-7084	Protein	denotes	TNFα
T22980	6314-6318	Protein	denotes	TNFα
T22979	6254-6258	Protein	denotes	RIP1
T22978	6093-6097	Protein	denotes	TNFα
T22977	5986-5990	Protein	denotes	FADD
T22976	5736-5740	Protein	denotes	RIP1
T22975	5372-5376	Protein	denotes	TNFα
T22974	5244-5248	Protein	denotes	TNFα
T22973	4578-4582	Protein	denotes	RIP1
T22972	4073-4077	Protein	denotes	MDM2
T22971	4066-4067	Protein	denotes	4
T22962	1901-1905	Protein	denotes	PDK1
T22961	1879-1883	Protein	denotes	RIP1
T22960	1508-1512	Protein	denotes	RIP1
T22959	1429-1433	Protein	denotes	RIP1
T22958	850-854	Protein	denotes	RIP1
T22957	824-828	Protein	denotes	TNFα
T22956	730-737	Protein	denotes	Myr-Akt
T22955	662-669	Protein	denotes	Myr-Akt
T22954	387-391	Protein	denotes	TNFα
T22953	260-264	Protein	denotes	RIP1
T22952	116-120	Protein	denotes	RIP1
T22970	4060-4065	Protein	denotes	FoxO1
T22969	3849-3853	Protein	denotes	RIP1
T22968	3523-3527	Protein	denotes	TNFα
T22967	3376-3380	Protein	denotes	TNFα
T22966	2650-2654	Protein	denotes	TNFα
T22965	2487-2491	Protein	denotes	RIP1
T22964	2155-2162	Protein	denotes	Myr-Akt
T22963	2038-2042	Protein	denotes	RIP1
R15406	T22954	T22993	themeOf	TNFα,synthesis
R15429	T22987	T23021	themeOf	TNFα,production
R15430	T22988	T23022	themeOf	TNFα,production
R15431	T22991	T23024	themeOf	RIP1,role
R15432	T22992	T23025	themeOf	RIP1,inhibitors
R15433	T22993	T22994	themeOf	synthesis,autocrine
R15434	T22995	T22996	themeOf	Expression,membrane-targeted
R15435	T22997	T22998	themeOf	expression,sufficient
R15436	T22999	T23000	themeOf	synthesis,activation
R15437	T23006	T23007	themeOf	phosphorylation,regulation
R15438	T23008	T23009	themeOf	synthesis,promote
R15439	T23014	T23015	themeOf	synthesis,increase
R15440	T23016	T23017	themeOf	production,mediating
R15441	T23018	T23019	themeOf	synthesis,activation
R15442	T23022	T23023	themeOf	production,increased
R15407	T22955	T22995	themeOf	Myr-Akt,Expression
R15408	T22955	T22996	themeOf	Myr-Akt,membrane-targeted
R15409	T22956	T22997	themeOf	Myr-Akt,expression
R15410	T22957	T22999	themeOf	TNFα,synthesis
R15411	T22958	T23001	themeOf	RIP1,kinase-dependent
R15412	T22960	T23002	themeOf	RIP1,inhibits
R15413	T22961	T23003	themeOf	RIP1,targeting
R15414	T22962	T23003	themeOf	PDK1,targeting
R15415	T22963	T23004	themeOf	RIP1,phosphorylation
R15416	T22964	T23005	themeOf	Myr-Akt,mutating
R15417	T22965	T23006	themeOf	RIP1,phosphorylation
R15418	T22966	T23008	themeOf	TNFα,synthesis
R15419	T22968	T23010	themeOf	TNFα,contributes
R15420	T22969	T23011	themeOf	RIP1,regulation
R15421	T22973	T23012	themeOf	RIP1,expression
R15422	T22977	T23013	themeOf	FADD,deficient
R15423	T22978	T23014	themeOf	TNFα,synthesis
R15424	T22979	T23017	causeOf	RIP1,mediating
R15425	T22980	T23016	themeOf	TNFα,production
R15426	T22981	T23018	themeOf	TNFα,synthesis
R15427	T22985	T23020	themeOf	FADD,loss
R15428	T22986	T23020	themeOf	caspase-8,loss

bionlp-st-ge-2016-test-ihmc

Id	Subject	Object	Predicate	Lexical cue
T23595	4053-4058	Protein	denotes	GSK-3
T23594	1907-1910	Protein	denotes	Akt
T23593	8031-8042	Protein	denotes	TNF-induced
T23592	6019-6031	Entity	denotes	macrophages,
T23591	5736-5747	Protein	denotes	RIP1 kinase
T23590	1879-1933	Protein	denotes	RIP1 kinase targeting PDK1, Akt or scaffolding factors
T23589	5312-5330	Protein	denotes	mTOR in our system
T23588	5302-5308	Protein	denotes	by Akt
T23587	1590-1667	Protein	denotes	the only enzyme established to specifically dephosphorylate this residue [45]
T23586	1142-1145	Protein	denotes	Akt
T23585	3849-3853	Protein	denotes	RIP1
T23584	5962-5984	Entity	denotes	mouse lung fibroblasts
T23583	8155-8182	Protein	denotes	efficient and specific RIP1
T23582	2091-2106	Entity	denotes	Ser381 residues
T23581	8183-8200	Entity	denotes	kinase inhibitors
T23580	3572-3575	Protein	denotes	JNK
T23579	1177-1183	Entity	denotes	mTORC1
T23578	2422-2436	Entity	denotes	Thr435 peptide
T23577	1503-1562	Protein	denotes	that RIP1 kinase inhibits a phosphatase that targets Thr308
T23576	2016-2022	Protein	denotes	of Akt
T23575	4073-4077	Protein	denotes	MDM2
T23574	7095-7114	Protein	denotes	by RIP1/Akt kinases
T23573	1429-1443	Protein	denotes	RIP1-dependent
T23572	2714-2735	Entity	denotes	Akt effector pathways
T23571	2749-2777	Entity	denotes	TORC1 in necroptotic control
T23570	6915-6923	Entity	denotes	membrane
T23569	4006-4009	Protein	denotes	Akt
T23568	260-271	Protein	denotes	RIP1 kinase
T23567	7975-7979	Protein	denotes	RIP1
T23566	2714-2717	Protein	denotes	Akt
T23565	2838-2844	Entity	denotes	mTORC1
T23564	1369-1372	Protein	denotes	Akt
T23563	7538-7542	Protein	denotes	mice
T23562	7382-7411	Protein	denotes	caspase-8 in epithelial cells
T23561	2996-3024	Entity	denotes	of additional Akt substrates
T23560	850-854	Protein	denotes	RIP1
T23559	4060-4067	Protein	denotes	FoxO1/4
T23558	5092-5103	Entity	denotes	by zVAD.fmk
T23557	850-871	Protein	denotes	RIP1 kinase-dependent
T23556	5411-5464	Entity	denotes	reconcile with the positive role of these proteins in
T23555	1513-1519	Protein	denotes	kinase
T23554	7077-7094	Protein	denotes	of TNFα synthesis
T23553	6438-6444	Protein	denotes	of Akt
T23552	48-51	Protein	denotes	Akt
T23551	894-900	Entity	denotes	Thr308
T23550	4860-4872	Protein	denotes	of mTOR [48]
T23549	6090-6107	Protein	denotes	in TNFα synthesis
T23548	7342-7411	Protein	denotes	RIP1/RIP3 kinase activities by FADD and caspase-8 in epithelial cells
T23547	1708-1718	Entity	denotes	of the PP2
T23546	2487-2491	Protein	denotes	RIP1
T23545	5244-5253	Protein	denotes	TNFα [49]
T23544	1456-1466	Entity	denotes	Akt Thr308
T23543	2023-2049	Protein	denotes	by recombinant RIP1 kinase
T23542	3240-3246	Protein	denotes	of JNK
T23541	467-473	Protein	denotes	of Akt
T23540	7373-7377	Protein	denotes	FADD
T23539	217-226	Entity	denotes	on Thr308
T23538	8062-8076	Protein	denotes	of RIP1 kinase
T23537	1856-1865	Entity	denotes	in Thr308
T23536	4768-4774	Protein	denotes	by Akt
T23535	917-923	Protein	denotes	of Akt
T23534	377-401	Protein	denotes	autocrine TNFα synthesis
T23533	3133-3139	Entity	denotes	mTORC1
T23532	637-669	Protein	denotes	active membrane-targeted Myr-Akt
T23531	3263-3277	Protein	denotes	ER stress [46]
T23530	4141-4147	Protein	denotes	of Akt
T23529	1731-1743	Entity	denotes	okadaic acid
T23528	6254-6258	Protein	denotes	RIP1
T23527	4372-4458	Entity	denotes	cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death
T23526	1503-1562	Protein	denotes	that RIP1 kinase inhibits a phosphatase that targets Thr308
T23525	4578-4582	Protein	denotes	RIP1
T23524	5986-6013	Entity	denotes	FADD-deficient Jurkat cells
T23523	7395-7411	Entity	denotes	epithelial cells
T23522	727-737	Protein	denotes	of Myr-Akt
T23521	567-586	Entity	denotes	the plasma membrane
T23520	1901-1905	Protein	denotes	PDK1
T23519	3140-3146	Protein	denotes	to JNK
T23518	3366-3372	Protein	denotes	of JNK
T23517	48-58	Protein	denotes	Akt kinase
T23516	4532-4547	Protein	denotes	Akt-independent
T23515	4066-4067	Protein	denotes	4
T23514	1879-1883	Protein	denotes	RIP1
T23513	1556-1562	Entity	denotes	Thr308
T23512	816-819	Protein	denotes	JNK
T23511	4789-4792	Protein	denotes	Akt
T23510	5736-5740	Protein	denotes	RIP1
T23509	7984-7988	Protein	denotes	RIP3
T23508	1945-1962	Protein	denotes	these two kinases
T23507	2614-2617	Protein	denotes	Akt
T23506	1456-1459	Protein	denotes	Akt
T23505	2650-2664	Protein	denotes	TNFα synthesis
T23504	2900-2925	Entity	denotes	additional Akt substrates
T23503	600-606	Protein	denotes	of Akt
T23502	2911-2914	Protein	denotes	Akt
T23501	1650-1667	Entity	denotes	this residue [45]
T23500	2398-2406	Protein	denotes	antibody
T23499	5918-5936	Entity	denotes	cell type specific
T23498	3839-3845	Protein	denotes	of Akt
T23497	2130-2162	Entity	denotes	these residues to Ala in Myr-Akt
T23496	2273-2290	Entity	denotes	of these residues
T23495	2038-2042	Protein	denotes	RIP1
T23494	361-364	Protein	denotes	JNK
T23493	2155-2162	Protein	denotes	Myr-Akt
T23492	3376-3380	Protein	denotes	TNFα
T23491	1748-1754	Entity	denotes	Thr308
T23490	2091-2097	Entity	denotes	Ser381
T23489	3933-3936	Protein	denotes	Akt
T23488	197-200	Protein	denotes	Akt
T23487	5687-5698	Protein	denotes	Akt pathway
T23486	1006-1022	Entity	denotes	of Thr308 of Akt
T23485	3010-3013	Protein	denotes	Akt
T23484	7098-7106	Protein	denotes	RIP1/Akt
T23483	8065-8069	Protein	denotes	RIP1
T23482	2294-2308	Protein	denotes	endogenous Akt
T23481	2592-2664	Entity	denotes	the key substrates of Akt that promote necrotic death and TNFα synthesis
T23480	7462-7466	Protein	denotes	TNFα
T23479	824-828	Protein	denotes	TNFα
T23478	260-264	Protein	denotes	RIP1
T23477	7627-7634	Protein	denotes	of TNFα
T23476	1019-1022	Protein	denotes	Akt
T23475	7352-7358	Protein	denotes	kinase
T23474	2062-2078	Entity	denotes	Thr146, 195/197,
T23473	1720-1744	Entity	denotes	inhibitor, okadaic acid,
T23654	7601-7653	Gene_expression	denotes	This increased production of TNFα during necroptosis
T23653	7382-7412	Localization	denotes	caspase-8 in epithelial cells
T23652	3209-3246	Regulation	denotes	of mTORC1-dependent regulation of JNK
T23651	4849-4872	Positive_regulation	denotes	activation of mTOR [48]
T23650	1590-1667	Gene_expression	denotes	the only enzyme established to specifically dephosphorylate this residue [45]
T23649	4372-4458	Localization	denotes	cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death
T23648	4364-4458	Positive_regulation	denotes	promote cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death
T23647	3122-3146	Binding	denotes	connecting mTORC1 to JNK
T23646	5736-5757	Positive_regulation	denotes	RIP1 kinase signaling
T23645	1453-1482	Phosphorylation	denotes	in Akt Thr308 phosphorylation
T23644	3351-3372	Positive_regulation	denotes	the activation of JNK
T23643	716-737	Gene_expression	denotes	expression of Myr-Akt
T23642	894-924	Phosphorylation	denotes	Thr308 phosphorylation of Akt,
T23641	1973-2086	Phosphorylation	denotes	Interestingly, we observed phosphorylation of Akt by recombinant RIP1 kinase in vitro on Thr146, 195/197, and 435
T23640	3810-3845	Regulation	denotes	necrosis-specific regulation of Akt
T23639	978-1022	Phosphorylation	denotes	Necroptotic phosphorylation of Thr308 of Akt
T23638	6286-6318	Regulation	denotes	mediating the production of TNFα
T23637	361-375	Positive_regulation	denotes	JNK activation
T23636	6032-6131	Positive_regulation	denotes	Akt signaling contributed more prominently to an increase in TNFα synthesis, rather than cell death
T23635	3504-3527	Translation	denotes	the translation of TNFα
T23634	163-226	Positive_regulation	denotes	promoting a selective increase in Akt phosphorylation on Thr308
T23633	1425-1482	Regulation	denotes	the RIP1-dependent increase in Akt Thr308 phosphorylation
T23632	173-226	Positive_regulation	denotes	a selective increase in Akt phosphorylation on Thr308
T23631	6296-6318	Gene_expression	denotes	the production of TNFα
T23630	4789-4803	Positive_regulation	denotes	Akt activation
T23629	4115-4147	Positive_regulation	denotes	to assume that activation of Akt
T23628	1503-1562	Negative_regulation	denotes	that RIP1 kinase inhibits a phosphatase that targets Thr308
T23627	7601-7653	Positive_regulation	denotes	This increased production of TNFα during necroptosis
T23626	1425-1482	Positive_regulation	denotes	the RIP1-dependent increase in Akt Thr308 phosphorylation
T23625	451-473	Phosphorylation	denotes	phosphorylation of Akt
T23624	8183-8200	Protein	denotes	kinase inhibitors
T23623	3593-3619	Entity	denotes	key inhibitor of apoptosis
T23622	7098-7106	Protein	denotes	RIP1/Akt
T23621	2477-2483	Protein	denotes	of Akt
T23620	5369-5376	Protein	denotes	by TNFα
T23619	2422-2428	Entity	denotes	Thr435
T23618	5831-5850	Entity	denotes	multiple cell types
T23617	4028-4034	Entity	denotes	mTORC1
T23616	6136-6169	Entity	denotes	se, unlike its role in L929 cells
T23615	3482-3488	Entity	denotes	mTORC1
T23614	4332-4347	Protein	denotes	the Akt pathway
T23613	4060-4067	Protein	denotes	FoxO1/4
T23612	4578-4590	Protein	denotes	RIP1 kinase,
T23611	644-661	Entity	denotes	membrane-targeted
T23610	6905-6972	Entity	denotes	of plasma membrane integrity characteristic for necrotic cell death
T23609	3520-3527	Protein	denotes	of TNFα
T23608	4372-4458	Protein	denotes	cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death
T23607	7103-7106	Protein	denotes	Akt
T23606	3849-3860	Protein	denotes	RIP1 kinase
T23605	2148-2162	Entity	denotes	Ala in Myr-Akt
T23604	5426-5464	Protein	denotes	the positive role of these proteins in
T23603	6032-6035	Protein	denotes	Akt
T23602	1079-1098	Entity	denotes	of known substrates
T23601	1138-1162	Entity	denotes	the Akt effector pathway
T23600	6311-6318	Protein	denotes	of TNFα
T23599	5596-5611	Entity	denotes	mammalian cells
T23598	116-120	Protein	denotes	RIP1
T23597	62-127	Protein	denotes	specifically engaged in the signaling downstream from RIP1 kinase
T23596	5761-5764	Protein	denotes	Akt
R15643	T23476	T23639	themeOf	Akt,Necroptotic phosphorylation of Thr308 of Akt
R15644	T23477	T23654	themeOf	of TNFα,This increased production of TNFα during necroptosis
R15645	T23486	T23476	partOf	of Thr308 of Akt,Akt
R15646	T23486	T23639	siteOf	of Thr308 of Akt,Necroptotic phosphorylation of Thr308 of Akt
R15647	T23494	T23637	themeOf	JNK,JNK activation
R15648	T23498	T23640	themeOf	of Akt,necrosis-specific regulation of Akt
R15649	T23506	T23645	themeOf	Akt,in Akt Thr308 phosphorylation
R15650	T23511	T23630	themeOf	Akt,Akt activation
R15651	T23518	T23644	themeOf	of JNK,the activation of JNK
R15652	T23519	T23647	themeOf	to JNK,connecting mTORC1 to JNK
R15653	T23522	T23643	themeOf	of Myr-Akt,expression of Myr-Akt
R15654	T23523	T23653	locationOf	epithelial cells,caspase-8 in epithelial cells
R15655	T23527	T23649	locationOf	"cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death","cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death"
R15656	T23530	T23629	themeOf	of Akt,to assume that activation of Akt
R15657	T23533	T23647	themeOf	mTORC1,connecting mTORC1 to JNK
R15658	T23535	T23642	themeOf	of Akt,"Thr308 phosphorylation of Akt,"
R15659	T23541	T23625	themeOf	of Akt,phosphorylation of Akt
R15660	T23542	T23652	themeOf	of JNK,of mTORC1-dependent regulation of JNK
R15661	T23543	T23641	causeOf	by recombinant RIP1 kinase,"Interestingly, we observed phosphorylation of Akt by recombinant RIP1 kinase in vitro on Thr146, 195/197, and 435"
R15662	T23544	T23506	partOf	Akt Thr308,Akt
R15663	T23544	T23645	siteOf	Akt Thr308,in Akt Thr308 phosphorylation
R15664	T23550	T23651	themeOf	of mTOR [48],activation of mTOR [48]
R15665	T23551	T23535	partOf	Thr308,of Akt
R15666	T23551	T23642	siteOf	Thr308,"Thr308 phosphorylation of Akt,"
R15667	T23555	T23628	causeOf	kinase,that RIP1 kinase inhibits a phosphatase that targets Thr308
R15668	T23562	T23653	themeOf	caspase-8 in epithelial cells,caspase-8 in epithelial cells
R15669	T23573	T23633	causeOf	RIP1-dependent,the RIP1-dependent increase in Akt Thr308 phosphorylation
R15670	T23576	T23641	themeOf	of Akt,"Interestingly, we observed phosphorylation of Akt by recombinant RIP1 kinase in vitro on Thr146, 195/197, and 435"
R15671	T23577	T23628	themeOf	that RIP1 kinase inhibits a phosphatase that targets Thr308,that RIP1 kinase inhibits a phosphatase that targets Thr308
R15672	T23587	T23650	themeOf	the only enzyme established to specifically dephosphorylate this residue [45],the only enzyme established to specifically dephosphorylate this residue [45]
R15673	T23591	T23646	causeOf	RIP1 kinase,RIP1 kinase signaling
R15674	T23600	T23631	themeOf	of TNFα,the production of TNFα
R15675	T23603	T23636	causeOf	Akt,"Akt signaling contributed more prominently to an increase in TNFα synthesis, rather than cell death"
R15676	T23608	T23648	themeOf	"cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death","promote cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death"
R15677	T23608	T23649	themeOf	"cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death","cell fates alternative to apoptosis, ranging from survival to non-apoptotic cell death"
R15678	T23609	T23635	themeOf	of TNFα,the translation of TNFα
R15679	T23626	T23633	themeOf	the RIP1-dependent increase in Akt Thr308 phosphorylation,the RIP1-dependent increase in Akt Thr308 phosphorylation
R15680	T23631	T23638	themeOf	the production of TNFα,mediating the production of TNFα
R15681	T23632	T23634	themeOf	a selective increase in Akt phosphorylation on Thr308,promoting a selective increase in Akt phosphorylation on Thr308
R15682	T23645	T23626	themeOf	in Akt Thr308 phosphorylation,the RIP1-dependent increase in Akt Thr308 phosphorylation
R15683	T23654	T23627	themeOf	This increased production of TNFα during necroptosis,This increased production of TNFα during necroptosis

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T24968	7616-7626	NN	denotes	production
T24967	7606-7615	VBD	denotes	increased
T24966	7601-7605	DT	denotes	This
T24965	7599-7600	.	denotes	.
T24964	7598-7599	NNP	denotes	]
T24963	7597-7598	CD	denotes	5
T24962	7596-7597	NNP	denotes	[
T24961	7594-7595	,	denotes	,
T24960	7593-7594	NNP	denotes	]
T24959	7592-7593	CD	denotes	4
T24958	7591-7592	NN	denotes	[
T24957	7583-7590	NN	denotes	disease
T24956	7575-7580	NNP	denotes	Crohn
T24955	7570-7574	IN	denotes	with
T24954	7561-7569	NNS	denotes	patients
T24953	7558-7560	IN	denotes	in
T24952	7556-7557	,	denotes	,
T24951	7548-7556	RB	denotes	possibly
T24950	7546-7547	,	denotes	,
T24949	7543-7546	CC	denotes	and
T24948	7538-7542	NNS	denotes	mice
T24947	7535-7537	IN	denotes	in
T24946	7522-7534	NN	denotes	inflammation
T24945	7511-7521	JJ	denotes	intestinal
T24944	7508-7510	IN	denotes	of
T24943	7496-7507	NN	denotes	development
T24942	7492-7495	DT	denotes	the
T24941	7489-7491	IN	denotes	in
T24940	7479-7488	VBG	denotes	resulting
T24939	7477-7478	,	denotes	,
T24938	7467-7477	NN	denotes	production
T24937	7462-7466	JJ	denotes	TNFα
T24936	7458-7461	CC	denotes	and
T24935	7446-7457	NN	denotes	necroptosis
T24934	7443-7445	IN	denotes	of
T24933	7437-7442	NN	denotes	cycle
T24932	7429-7436	RB	denotes	forward
T24931	7424-7428	NN	denotes	feed
T24930	7422-7423	DT	denotes	a
T24929	7412-7421	VBZ	denotes	unleashes
T24928	7406-7411	NNS	denotes	cells
T24927	7395-7405	JJ	denotes	epithelial
T24926	7392-7394	IN	denotes	in
T24925	7382-7391	JJ	denotes	caspase-8
T24924	7378-7381	CC	denotes	and
T24923	7373-7377	NNP	denotes	FADD
T24922	7370-7372	IN	denotes	by
T24921	7359-7369	NNS	denotes	activities
T24920	7352-7358	NN	denotes	kinase
T24919	7342-7351	CD	denotes	RIP1/RIP3
T24918	7337-7341	IN	denotes	over
T24917	7329-7336	NN	denotes	control
T24916	7326-7328	IN	denotes	of
T24915	7321-7325	NN	denotes	loss
T24914	7317-7320	DT	denotes	the
T24913	7312-7316	IN	denotes	that
T24912	7305-7311	VBD	denotes	showed
T24911	7298-7304	NNS	denotes	papers
T24910	7291-7297	JJ	denotes	recent
T24909	7287-7290	CD	denotes	Two
T24908	7285-7286	.	denotes	.
T24907	7279-7285	NN	denotes	notion
T24906	7274-7278	DT	denotes	this
T24905	7266-7273	VB	denotes	support
T24904	7263-7265	TO	denotes	to
T24903	7255-7262	VBZ	denotes	appears
T24902	7250-7254	NNS	denotes	data
T24901	7245-7249	NN	denotes	vivo
T24900	7242-7244	IN	denotes	in
T24899	7234-7241	JJ	denotes	Initial
T24898	7232-7233	.	denotes	.
T24897	7223-7232	VBG	denotes	signaling
T24896	7210-7222	JJ	denotes	inflammatory
T24895	7199-7209	JJ	denotes	pathologic
T24894	7196-7198	IN	denotes	of
T24893	7185-7195	NN	denotes	inhibition
T24892	7181-7184	DT	denotes	the
T24891	7177-7180	IN	denotes	for
T24890	7170-7176	NN	denotes	target
T24889	7160-7169	JJ	denotes	molecular
T24888	7156-7159	JJ	denotes	new
T24887	7154-7155	DT	denotes	a
T24886	7144-7153	VB	denotes	represent
T24885	7140-7143	MD	denotes	may
T24884	7132-7139	NN	denotes	pathway
T24883	7127-7131	DT	denotes	this
T24882	7125-7126	,	denotes	,
T24881	7116-7125	RB	denotes	Therefore
T24880	7114-7115	.	denotes	.
T24879	7107-7114	NNS	denotes	kinases
T24878	7098-7106	JJ	denotes	RIP1/Akt
T24877	7095-7097	IN	denotes	by
T24876	7085-7094	NN	denotes	synthesis
T24875	7080-7084	NNP	denotes	TNFα
T24874	7077-7079	IN	denotes	of
T24873	7066-7076	NN	denotes	activation
T24872	7057-7065	JJ	denotes	specific
T24871	7053-7056	DT	denotes	the
T24870	7050-7052	TO	denotes	to
T24869	7046-7049	JJ	denotes	due
T24868	7034-7045	NN	denotes	necroptosis
T24867	7031-7033	IN	denotes	of
T24866	7021-7030	NN	denotes	component
T24865	7011-7020	JJ	denotes	regulated
T24864	7007-7010	CC	denotes	and
T24863	6997-7006	JJ	denotes	intrinsic
T24862	6994-6996	DT	denotes	an
T24861	6991-6993	VBZ	denotes	is
T24860	6988-6990	PRP	denotes	it
T24859	6983-6987	IN	denotes	that
T24858	6978-6982	RB	denotes	also
T24857	6974-6977	CC	denotes	but
T24856	6972-6973	,	denotes	,
T24855	6967-6972	NN	denotes	death
T24854	6962-6966	NN	denotes	cell
T24853	6953-6961	JJ	denotes	necrotic
T24852	6949-6952	IN	denotes	for
T24851	6934-6948	NN	denotes	characteristic
T24850	6924-6933	NN	denotes	integrity
T24849	6915-6923	NN	denotes	membrane
T24848	6908-6914	NN	denotes	plasma
T24847	6905-6907	IN	denotes	of
T24846	6900-6904	NN	denotes	loss
T24845	6894-6899	JJ	denotes	rapid
T24844	6891-6893	IN	denotes	of
T24843	6884-6890	NN	denotes	virtue
T24842	6880-6883	DT	denotes	the
T24841	6877-6879	IN	denotes	by
T24840	6869-6876	NNS	denotes	systems
T24839	6860-6868	JJ	denotes	cellular
T24838	6857-6859	IN	denotes	of
T24837	6849-6856	NN	denotes	variety
T24836	6847-6848	DT	denotes	a
T24835	6844-6846	IN	denotes	in
T24834	6832-6843	NN	denotes	necroptosis
T24833	6820-6831	VBZ	denotes	accompanies
T24832	6810-6819	RB	denotes	passively
T24831	6805-6809	RB	denotes	only
T24830	6801-6804	RB	denotes	not
T24829	6788-6800	NN	denotes	inflammation
T24828	6783-6787	IN	denotes	that
T24827	6776-6782	NN	denotes	notion
T24826	6766-6775	JJ	denotes	important
T24825	6763-6765	DT	denotes	an
T24824	6753-6762	VBP	denotes	highlight
T24823	6745-6752	NNS	denotes	results
T24822	6741-6744	PRP$	denotes	Our
T24821	6739-6740	.	denotes	.
T24820	6738-6739	NNP	denotes	]
T24819	6736-6738	CD	denotes	51
T24818	6735-6736	NNP	denotes	[
T24817	6733-6734	,	denotes	,
T24816	6732-6733	NNP	denotes	]
T24815	6730-6732	CD	denotes	50
T24814	6729-6730	NNP	denotes	[
T24813	6727-6728	,	denotes	,
T24812	6726-6727	NNP	denotes	]
T24811	6725-6726	CD	denotes	6
T24810	6724-6725	NNP	denotes	[
T24809	6722-6723	,	denotes	,
T24808	6721-6722	NNP	denotes	]
T24807	6720-6721	CD	denotes	5
T24806	6719-6720	NNP	denotes	[
T24805	6717-6718	,	denotes	,
T24804	6716-6717	NNP	denotes	]
T24803	6715-6716	CD	denotes	1
T24802	6714-6715	NN	denotes	[
T24801	6709-6713	NN	denotes	vivo
T24800	6706-6708	IN	denotes	in
T24799	6702-6705	CC	denotes	and
T24798	6696-6701	NN	denotes	vitro
T24797	6693-6695	IN	denotes	in
T24796	6688-6692	DT	denotes	both
T24795	6686-6687	,	denotes	,
T24794	6675-6686	NN	denotes	necroptosis
T24793	6673-6674	,	denotes	,
T24792	6666-6673	NN	denotes	subtype
T24791	6656-6665	JJ	denotes	regulated
T24790	6652-6655	PRP$	denotes	its
T24789	6649-6651	IN	denotes	as
T24788	6644-6648	RB	denotes	well
T24787	6641-6643	RB	denotes	as
T24786	6635-6640	NN	denotes	death
T24785	6630-6634	NN	denotes	cell
T24784	6621-6629	JJ	denotes	necrotic
T24783	6618-6620	IN	denotes	of
T24782	6605-6617	NNS	denotes	consequences
T24781	6595-6604	JJ	denotes	important
T24780	6590-6594	RBS	denotes	most
T24779	6586-6589	DT	denotes	the
T24778	6583-6585	IN	denotes	of
T24777	6579-6582	CD	denotes	one
T24776	6576-6578	VBZ	denotes	is
T24775	6563-6575	NN	denotes	inflammation
T24774	6556-6562	JJ	denotes	Robust
T24773	6554-6555	.	denotes	.
T24772	6553-6554	NNP	denotes	]
T24771	6551-6553	CD	denotes	10
T24770	6550-6551	NNP	denotes	[
T24769	6548-6549	,	denotes	,
T24768	6547-6548	NNP	denotes	]
T24767	6546-6547	CD	denotes	6
T24766	6545-6546	NNP	denotes	[
T24765	6543-6544	,	denotes	,
T24764	6542-6543	NNP	denotes	]
T24763	6541-6542	CD	denotes	5
T24762	6540-6541	NN	denotes	[
T24761	6531-6539	NN	denotes	necrosis
T24760	6521-6530	VBN	denotes	regulated
T24759	6518-6520	IN	denotes	of
T24758	6513-6517	NN	denotes	form
T24757	6508-6512	DT	denotes	this
T24756	6495-6507	VBG	denotes	accompanying
T24755	6482-6494	RB	denotes	specifically
T24754	6480-6481	,	denotes	,
T24753	6471-6480	VBG	denotes	signaling
T24667	5968-5972	NN	denotes	lung
T24666	5962-5967	NN	denotes	mouse
T24665	5959-5961	IN	denotes	in
T24664	5957-5958	,	denotes	,
T24663	5946-5957	RB	denotes	Importantly
T24662	5944-5945	.	denotes	.
T24661	5937-5944	NN	denotes	fashion
T24660	5928-5936	JJ	denotes	specific
T24659	5923-5927	NN	denotes	type
T24658	5918-5922	NN	denotes	cell
T24657	5916-5917	DT	denotes	a
T24656	5913-5915	IN	denotes	in
T24655	5906-5912	VBZ	denotes	varies
T24654	5895-5905	NN	denotes	connection
T24653	5890-5894	DT	denotes	this
T24652	5887-5889	IN	denotes	of
T24651	5874-5886	NN	denotes	significance
T24650	5870-5873	DT	denotes	the
T24649	5868-5869	,	denotes	,
T24648	5864-5868	NN	denotes	time
T24647	5859-5863	JJ	denotes	same
T24646	5855-5858	DT	denotes	the
T24645	5852-5854	IN	denotes	At
T24644	5850-5851	.	denotes	.
T24643	5845-5850	NNS	denotes	types
T24642	5840-5844	NN	denotes	cell
T24641	5831-5839	JJ	denotes	multiple
T24640	5828-5830	IN	denotes	in
T24639	5819-5827	VBN	denotes	observed
T24638	5816-5818	VBZ	denotes	is
T24637	5811-5815	DT	denotes	that
T24636	5801-5810	VBG	denotes	signaling
T24635	5789-5800	JJ	denotes	necroptotic
T24634	5786-5788	IN	denotes	of
T24633	5778-5785	NN	denotes	feature
T24632	5770-5777	JJ	denotes	general
T24631	5768-5769	DT	denotes	a
T24630	5765-5767	VBZ	denotes	is
T24629	5761-5764	NNP	denotes	Akt
T24628	5758-5760	TO	denotes	to
T24627	5748-5757	VBG	denotes	signaling
T24626	5741-5747	NN	denotes	kinase
T24625	5736-5740	CD	denotes	RIP1
T24624	5731-5735	IN	denotes	that
T24623	5722-5730	VBD	denotes	revealed
T24622	5717-5721	NNS	denotes	data
T24621	5713-5716	PRP$	denotes	our
T24620	5711-5712	,	denotes	,
T24619	5700-5711	RB	denotes	Importantly
T24618	5698-5699	.	denotes	.
T24617	5691-5698	NN	denotes	pathway
T24616	5687-5690	NNP	denotes	Akt
T24615	5684-5686	IN	denotes	by
T24614	5672-5683	NN	denotes	necroptosis
T24613	5661-5671	NN	denotes	regulation
T24612	5657-5660	DT	denotes	the
T24611	5654-5656	IN	denotes	in
T24610	5649-5653	NN	denotes	role
T24609	5645-5648	PRP$	denotes	its
T24608	5634-5644	VB	denotes	understand
T24607	5627-5633	JJR	denotes	better
T24606	5624-5626	TO	denotes	to
T24605	5615-5623	VBN	denotes	required
T24604	5612-5614	VBZ	denotes	is
T24603	5606-5611	NNS	denotes	cells
T24602	5596-5605	JJ	denotes	mammalian
T24601	5593-5595	IN	denotes	in
T24600	5583-5592	NN	denotes	autophagy
T24599	5570-5582	JJ	denotes	pro-survival
T24598	5566-5569	CC	denotes	and
T24597	5556-5565	JJ	denotes	pro-death
T24596	5548-5555	IN	denotes	between
T24595	5532-5547	VBG	denotes	differentiating
T24594	5524-5531	NNS	denotes	factors
T24593	5520-5523	DT	denotes	the
T24592	5517-5519	IN	denotes	of
T24591	5502-5516	NN	denotes	identification
T24590	5494-5501	JJ	denotes	further
T24589	5492-5493	,	denotes	,
T24588	5485-5492	RB	denotes	Clearly
T24587	5483-5484	.	denotes	.
T24586	5478-5483	NN	denotes	death
T24585	5465-5477	JJ	denotes	zVAD-induced
T24584	5462-5464	IN	denotes	in
T24583	5453-5461	NNS	denotes	proteins
T24582	5447-5452	DT	denotes	these
T24581	5444-5446	IN	denotes	of
T24580	5439-5443	NN	denotes	role
T24579	5430-5438	JJ	denotes	positive
T24578	5426-5429	DT	denotes	the
T24577	5421-5425	IN	denotes	with
T24576	5411-5420	VB	denotes	reconcile
T24575	5408-5410	TO	denotes	to
T24574	5398-5407	JJ	denotes	difficult
T24573	5393-5397	RBR	denotes	more
T24572	5390-5392	VBZ	denotes	is
T24571	5387-5389	PRP	denotes	it
T24570	5385-5386	,	denotes	,
T24569	5378-5385	RB	denotes	however
T24568	5376-5377	,	denotes	,
T24567	5372-5376	NNP	denotes	TNFα
T24566	5369-5371	IN	denotes	by
T24565	5361-5368	VBN	denotes	induced
T24564	5349-5360	NN	denotes	necroptosis
T24563	5346-5348	TO	denotes	to
T24562	5335-5345	VB	denotes	contribute
T24561	5331-5334	MD	denotes	may
T24560	5324-5330	NN	denotes	system
T24559	5320-5323	PRP$	denotes	our
T24558	5317-5319	IN	denotes	in
T24557	5312-5316	NNP	denotes	mTOR
T24556	5309-5311	CC	denotes	or
T24555	5305-5308	NNP	denotes	Akt
T24554	5302-5304	IN	denotes	by
T24553	5292-5301	NN	denotes	autophagy
T24552	5289-5291	IN	denotes	of
T24551	5278-5288	NN	denotes	inhibition
T24550	5274-5277	DT	denotes	the
T24549	5269-5273	IN	denotes	that
T24548	5260-5268	VBZ	denotes	suggests
T24547	5255-5259	DT	denotes	This
T24546	5253-5254	.	denotes	.
T24545	5252-5253	NNP	denotes	]
T24544	5250-5252	CD	denotes	49
T24543	5249-5250	NNP	denotes	[
T24542	5244-5248	NNP	denotes	TNFα
T24541	5241-5243	IN	denotes	by
T24540	5229-5240	NN	denotes	necroptosis
T24539	5220-5228	VBZ	denotes	promotes
T24538	5210-5219	JJ	denotes	autophagy
T24537	5207-5209	IN	denotes	of
T24536	5195-5206	NN	denotes	inihibition
T24535	5190-5194	IN	denotes	that
T24534	5184-5189	VBN	denotes	found
T24533	5179-5183	VBP	denotes	have
T24532	5177-5178	,	denotes	,
T24531	5173-5177	NNS	denotes	data
T24530	5161-5172	JJ	denotes	unpublished
T24529	5158-5160	IN	denotes	in
T24528	5148-5157	PRP	denotes	ourselves
T24527	5138-5147	VBG	denotes	including
T24526	5136-5137	,	denotes	,
T24525	5130-5136	NNS	denotes	Others
T24524	5128-5129	.	denotes	.
T24523	5127-5128	NNP	denotes	]
T24522	5125-5127	CD	denotes	14
T24521	5124-5125	NNP	denotes	[
T24520	5122-5123	,	denotes	,
T24519	5121-5122	NNP	denotes	]
T24518	5119-5121	CD	denotes	11
T24517	5118-5119	NNP	denotes	[
T24516	5112-5117	NNS	denotes	cells
T24515	5107-5111	NNP	denotes	L929
T24514	5104-5106	IN	denotes	in
T24513	5095-5103	NNP	denotes	zVAD.fmk
T24512	5092-5094	IN	denotes	by
T24511	5084-5091	VBN	denotes	induced
T24510	5072-5083	NN	denotes	necroptosis
T24509	5063-5071	VBZ	denotes	promotes
T24508	5053-5062	JJ	denotes	autophagy
T24507	5050-5052	IN	denotes	of
T24506	5039-5049	NN	denotes	activation
T24505	5034-5038	IN	denotes	that
T24504	5024-5033	VBD	denotes	suggested
T24503	5016-5023	NNS	denotes	studies
T24502	5008-5015	JJ	denotes	Several
T24501	5006-5007	.	denotes	.
T24500	4996-5006	NNS	denotes	situations
T24499	4988-4995	JJ	denotes	various
T24498	4985-4987	IN	denotes	in
T24497	4973-4984	NN	denotes	necroptosis
T24496	4965-4972	VB	denotes	inhibit
T24495	4961-4964	CC	denotes	and
T24494	4953-4960	VB	denotes	promote
T24493	4948-4952	DT	denotes	both
T24492	4944-4947	MD	denotes	can
T24491	4941-4943	PRP	denotes	it
T24490	4937-4940	CC	denotes	and
T24489	4929-4936	JJ	denotes	complex
T24488	4924-4928	RB	denotes	very
T24487	4921-4923	VBZ	denotes	is
T24486	4913-4920	JJ	denotes	general
T24485	4910-4912	IN	denotes	in
T24484	4904-4909	NN	denotes	death
T24483	4899-4903	NN	denotes	cell
T24482	4896-4898	IN	denotes	in
T24481	4886-4895	NN	denotes	autophagy
T24480	4883-4885	IN	denotes	of
T24479	4878-4882	NN	denotes	role
T24478	4874-4877	DT	denotes	The
T25069	8260-8261	.	denotes	.
T25068	8250-8260	NNS	denotes	conditions
T25067	8244-8249	DT	denotes	these
T25066	8235-8243	VBG	denotes	treating
T25065	8231-8234	IN	denotes	for
T25016	7937-7942	NN	denotes	paper
T25015	7930-7936	JJ	denotes	recent
T25014	7922-7929	DT	denotes	another
T25013	7920-7921	,	denotes	,
T25012	7915-7920	NNS	denotes	lines
T25011	7909-7914	DT	denotes	these
T25010	7903-7908	IN	denotes	Along
T25009	7901-7902	.	denotes	.
T25008	7896-7901	NN	denotes	death
T25007	7888-7895	NN	denotes	patient
T25006	7884-7887	CC	denotes	and
T25005	7876-7883	NN	denotes	failure
T25004	7870-7875	NN	denotes	organ
T25003	7861-7869	JJ	denotes	multiple
T25002	7858-7860	IN	denotes	of
T25001	7852-7857	NN	denotes	cause
T25000	7844-7851	JJ	denotes	primary
T24999	7840-7843	DT	denotes	the
T24998	7837-7839	VBZ	denotes	is
T24997	7831-7836	NN	denotes	death
T24996	7826-7830	NN	denotes	cell
T24995	7817-7825	JJ	denotes	necrotic
T24994	7804-7816	VBG	denotes	accompanying
T24993	7791-7803	NN	denotes	inflammation
T24992	7779-7790	JJ	denotes	hyper-acute
T24991	7773-7778	WRB	denotes	where
T24990	7771-7772	,	denotes	,
T24989	7761-7771	NNS	denotes	infections
T24988	7751-7760	JJ	denotes	bacterial
T24987	7745-7750	JJ	denotes	acute
T24986	7741-7744	CC	denotes	and
T24985	7728-7740	NN	denotes	pancreatitis
T24984	7716-7727	VBG	denotes	necrotizing
T24983	7713-7715	IN	denotes	as
T24982	7708-7712	JJ	denotes	such
T24981	7706-7707	,	denotes	,
T24980	7698-7706	NNS	denotes	diseases
T24979	7686-7697	JJ	denotes	necrotizing
T24978	7680-7685	JJ	denotes	acute
T24977	7676-7679	IN	denotes	for
T24976	7666-7675	JJ	denotes	important
T24975	7663-7665	VB	denotes	be
T24974	7658-7662	RB	denotes	also
T24973	7654-7657	MD	denotes	may
T24972	7642-7653	NN	denotes	necroptosis
T24971	7635-7641	IN	denotes	during
T24970	7630-7634	NNP	denotes	TNFα
T24969	7627-7629	IN	denotes	of
T24477	4872-4873	.	denotes	.
T24476	4871-4872	NNP	denotes	]
T24475	4869-4871	CD	denotes	48
T24474	4868-4869	NNP	denotes	[
T24473	4863-4867	NNP	denotes	mTOR
T24472	4860-4862	IN	denotes	of
T24471	4849-4859	NN	denotes	activation
T24470	4841-4848	IN	denotes	through
T24469	4831-4840	NN	denotes	autophagy
T24468	4828-4830	IN	denotes	of
T24467	4817-4827	NN	denotes	inhibition
T24466	4813-4816	DT	denotes	the
T24465	4810-4812	TO	denotes	to
T24464	4804-4809	VBZ	denotes	leads
T24463	4793-4803	NN	denotes	activation
T24462	4789-4792	NNP	denotes	Akt
T24461	4787-4788	.	denotes	.
T24460	4778-4787	JJ	denotes	autophagy
T24459	4775-4777	VBZ	denotes	is
T24458	4771-4774	NNP	denotes	Akt
T24457	4768-4770	IN	denotes	by
T24456	4762-4767	NN	denotes	death
T24455	4757-4761	NN	denotes	cell
T24454	4754-4756	IN	denotes	of
T24453	4743-4753	NN	denotes	regulation
T24452	4739-4742	DT	denotes	the
T24040	2329-2335	CC	denotes	either
T24039	2323-2328	VBG	denotes	using
T24038	2317-2322	NNS	denotes	cells
T24037	2312-2316	NNP	denotes	L929
T24036	2309-2311	IN	denotes	in
T24035	2305-2308	NNP	denotes	Akt
T24034	2294-2304	JJ	denotes	endogenous
T24033	2291-2293	IN	denotes	on
T24032	2282-2290	NNS	denotes	residues
T24031	2276-2281	DT	denotes	these
T24030	2273-2275	IN	denotes	of
T24029	2257-2272	NN	denotes	phosphorylation
T24028	2249-2256	VB	denotes	confirm
T24027	2246-2248	TO	denotes	to
T24026	2241-2245	JJ	denotes	able
T24025	2237-2240	RB	denotes	not
T24024	2232-2236	VBD	denotes	were
T24023	2229-2231	PRP	denotes	we
T24022	2227-2228	,	denotes	,
T24021	2220-2227	RB	denotes	However
T24020	2218-2219	.	denotes	.
T24019	2207-2218	NN	denotes	necroptosis
T24018	2199-2206	VB	denotes	promote
T24017	2196-2198	TO	denotes	to
T24016	2188-2195	NN	denotes	ability
T24015	2184-2187	PRP$	denotes	its
T24014	2181-2183	IN	denotes	of
T24013	2176-2180	NN	denotes	loss
T24012	2172-2175	DT	denotes	the
T24011	2169-2171	TO	denotes	to
T24010	2163-2168	VBZ	denotes	leads
T24009	2155-2162	NNP	denotes	Myr-Akt
T24008	2152-2154	IN	denotes	in
T24007	2148-2151	NNP	denotes	Ala
T24006	2145-2147	TO	denotes	to
T24005	2136-2144	NNS	denotes	residues
T24004	2130-2135	DT	denotes	these
T24003	2121-2129	VBG	denotes	mutating
T24002	2119-2120	,	denotes	,
T24001	2108-2119	RB	denotes	Furthermore
T24000	2106-2107	.	denotes	.
T23999	2098-2106	NNS	denotes	residues
T23998	2091-2097	CD	denotes	Ser381
T23997	2087-2090	CC	denotes	and
T23996	2083-2086	CD	denotes	435
T23995	2079-2082	CC	denotes	and
T23994	2077-2078	,	denotes	,
T23993	2070-2077	CD	denotes	195/197
T23992	2068-2069	,	denotes	,
T23991	2062-2068	NNP	denotes	Thr146
T23990	2059-2061	IN	denotes	on
T23989	2053-2058	NN	denotes	vitro
T23988	2050-2052	IN	denotes	in
T23987	2043-2049	NN	denotes	kinase
T23986	2038-2042	NNP	denotes	RIP1
T23985	2026-2037	JJ	denotes	recombinant
T23984	2023-2025	IN	denotes	by
T23983	2019-2022	NNP	denotes	Akt
T23982	2016-2018	IN	denotes	of
T23981	2000-2015	NN	denotes	phosphorylation
T23980	1991-1999	VBD	denotes	observed
T23979	1988-1990	PRP	denotes	we
T23978	1986-1987	,	denotes	,
T23977	1973-1986	RB	denotes	Interestingly
T23976	1971-1972	.	denotes	.
T23975	1963-1971	RB	denotes	together
T23974	1955-1962	NNS	denotes	kinases
T23973	1951-1954	CD	denotes	two
T23972	1945-1950	DT	denotes	these
T23971	1939-1944	VBP	denotes	bring
T23970	1934-1938	WDT	denotes	that
T23969	1926-1933	NNS	denotes	factors
T23968	1914-1925	VBG	denotes	scaffolding
T23967	1911-1913	CC	denotes	or
T23966	1907-1910	NNP	denotes	Akt
T23965	1905-1906	,	denotes	,
T23964	1901-1905	NNP	denotes	PDK1
T23963	1891-1900	VBG	denotes	targeting
T23962	1884-1890	NN	denotes	kinase
T23961	1879-1883	CD	denotes	RIP1
T23960	1874-1878	IN	denotes	from
T23959	1866-1873	NNS	denotes	results
T23958	1859-1865	CD	denotes	Thr308
T23957	1856-1858	IN	denotes	in
T23956	1847-1855	NN	denotes	increase
T23955	1843-1846	DT	denotes	the
T23954	1838-1842	IN	denotes	that
T23953	1835-1837	VBZ	denotes	is
T23952	1823-1834	NN	denotes	possibility
T23951	1815-1822	DT	denotes	Another
T23950	1813-1814	.	denotes	.
T23949	1808-1813	NNS	denotes	cells
T23948	1803-1807	CD	denotes	L929
T23947	1800-1802	IN	denotes	in
T23946	1788-1799	NN	denotes	necroptosis
T23945	1785-1787	IN	denotes	of
T23944	1774-1784	NN	denotes	activation
T23943	1771-1773	CC	denotes	or
T23942	1755-1770	NN	denotes	phosphorylation
T23941	1748-1754	CD	denotes	Thr308
T23940	1745-1747	IN	denotes	on
T23939	1743-1744	,	denotes	,
T23938	1739-1743	NN	denotes	acid
T23937	1731-1738	JJ	denotes	okadaic
T23936	1729-1730	,	denotes	,
T23935	1720-1729	NN	denotes	inhibitor
T23934	1715-1719	NNP	denotes	PP2A
T23933	1711-1714	DT	denotes	the
T23932	1708-1710	IN	denotes	of
T23931	1701-1707	NN	denotes	effect
T23930	1697-1700	DT	denotes	any
T23929	1689-1696	VB	denotes	observe
T23928	1685-1688	RB	denotes	not
T23927	1681-1684	VBD	denotes	did
T23926	1678-1680	PRP	denotes	we
T23925	1676-1677	,	denotes	,
T23924	1669-1676	RB	denotes	However
T23923	1667-1668	.	denotes	.
T23922	1666-1667	NNP	denotes	]
T23921	1664-1666	CD	denotes	45
T23920	1663-1664	NNP	denotes	[
T23919	1655-1662	NN	denotes	residue
T23918	1650-1654	DT	denotes	this
T23917	1634-1649	VB	denotes	dephosphorylate
T23916	1621-1633	RB	denotes	specifically
T23915	1618-1620	TO	denotes	to
T23914	1606-1617	VBN	denotes	established
T23913	1599-1605	NN	denotes	enzyme
T23912	1594-1598	JJ	denotes	only
T23911	1590-1593	DT	denotes	the
T23910	1587-1589	VBZ	denotes	is
T23909	1582-1586	NNP	denotes	PP2A
T23908	1580-1581	,	denotes	,
T23907	1571-1580	NN	denotes	knowledge
T23906	1567-1570	PRP$	denotes	our
T23905	1564-1566	TO	denotes	To
T23904	1562-1563	.	denotes	.
T23903	1556-1562	NNP	denotes	Thr308
T23902	1548-1555	VBZ	denotes	targets
T23901	1543-1547	WDT	denotes	that
T23900	1531-1542	NN	denotes	phosphatase
T23899	1529-1530	DT	denotes	a
T23898	1520-1528	VBZ	denotes	inhibits
T23897	1513-1519	NN	denotes	kinase
T23896	1508-1512	CD	denotes	RIP1
T23895	1503-1507	IN	denotes	that
T23894	1500-1502	VBZ	denotes	is
T23893	1488-1499	NN	denotes	possibility
T23892	1484-1487	CD	denotes	One
T23891	1482-1483	.	denotes	?
T23890	1467-1482	NN	denotes	phosphorylation
T23889	1460-1466	NNP	denotes	Thr308
T23888	1456-1459	NNP	denotes	Akt
T23887	1453-1455	IN	denotes	in
T23886	1444-1452	NN	denotes	increase
T23885	1429-1443	JJ	denotes	RIP1-dependent
T23884	1425-1428	DT	denotes	the
T23883	1422-1424	IN	denotes	of
T23882	1412-1421	NN	denotes	mechanism
T23881	1408-1411	DT	denotes	the
T23880	1405-1407	VBZ	denotes	is
T23879	1400-1404	WP	denotes	what
T23878	1398-1399	,	denotes	,
T23877	1393-1398	RB	denotes	First
T23876	1391-1392	.	denotes	.
T23875	1380-1391	NN	denotes	necroptosis
T23874	1373-1379	IN	denotes	during
T23873	1369-1372	NNP	denotes	Akt
T23872	1366-1368	IN	denotes	of
T23871	1355-1365	NN	denotes	regulation
T23870	1346-1354	JJ	denotes	specific
T23869	1342-1345	DT	denotes	the
T23868	1339-1341	TO	denotes	to
T23867	1330-1338	JJ	denotes	relevant
T23866	1320-1329	NNS	denotes	questions
T23865	1308-1319	JJ	denotes	mechanistic
T23864	1298-1307	JJ	denotes	important
T23863	1293-1297	DT	denotes	some
T23862	1287-1292	VB	denotes	raise
T23861	1279-1286	NNS	denotes	results
T23860	1275-1278	PRP$	denotes	Our
T23859	1273-1274	.	denotes	.
T23858	1268-1273	NN	denotes	death
T23857	1263-1267	NN	denotes	cell
T23856	1260-1262	IN	denotes	of
T23855	1255-1259	NN	denotes	form
T23854	1250-1254	DT	denotes	this
T23853	1247-1249	IN	denotes	of
T23852	1238-1246	NN	denotes	mediator
T23851	1234-1237	JJ	denotes	new
T24752	6458-6470	JJ	denotes	inflammatory
T24751	6448-6457	VBN	denotes	increased
T24750	6445-6447	TO	denotes	to
T24749	6441-6444	NNP	denotes	Akt
T24748	6438-6440	IN	denotes	of
T24747	6425-6437	NN	denotes	contribution
T24746	6419-6424	JJ	denotes	major
T24745	6415-6418	DT	denotes	the
T24744	6405-6414	VB	denotes	highlight
T24743	6401-6404	CC	denotes	and
T24742	6390-6400	NNS	denotes	mechanisms
T24741	6380-6389	VBG	denotes	signaling
T24740	6368-6379	JJ	denotes	necroptotic
T24739	6365-6367	IN	denotes	of
T24738	6354-6364	NN	denotes	complexity
T24737	6345-6353	VBG	denotes	emerging
T24736	6341-6344	DT	denotes	the
T24735	6331-6340	VBP	denotes	emphasize
T24734	6326-6330	NNS	denotes	data
T24733	6320-6325	DT	denotes	These
T24732	6318-6319	.	denotes	.
T24731	6314-6318	NNP	denotes	TNFα
T24730	6311-6313	IN	denotes	of
T24729	6300-6310	NN	denotes	production
T24728	6296-6299	DT	denotes	the
T24727	6286-6295	VBG	denotes	mediating
T24726	6283-6285	IN	denotes	in
T24725	6278-6282	NN	denotes	role
T24724	6268-6277	JJ	denotes	important
T24723	6265-6267	DT	denotes	an
T24722	6259-6264	VBZ	denotes	plays
T24721	6254-6258	NNP	denotes	RIP1
T24720	6252-6253	,	denotes	,
T24719	6241-6252	NN	denotes	necroptosis
T24718	6238-6240	IN	denotes	in
T24717	6233-6237	NN	denotes	role
T24716	6229-6232	PRP$	denotes	its
T24715	6226-6228	TO	denotes	to
T24714	6217-6225	NN	denotes	addition
T24713	6214-6216	IN	denotes	in
T24712	6212-6213	,	denotes	,
T24711	6208-6212	IN	denotes	that
T24710	6195-6207	VBN	denotes	demonstrated
T24709	6191-6194	VBZ	denotes	has
T24708	6189-6190	NNP	denotes	]
T24707	6187-6189	CD	denotes	15
T24706	6186-6187	NNP	denotes	[
T24705	6180-6185	NN	denotes	study
T24704	6173-6179	JJ	denotes	recent
T24703	6171-6172	DT	denotes	A
T24702	6169-6170	.	denotes	.
T24701	6164-6169	NNS	denotes	cells
T24700	6159-6163	CD	denotes	L929
T24699	6156-6158	IN	denotes	in
T24698	6151-6155	NN	denotes	role
T24697	6147-6150	PRP$	denotes	its
T24696	6140-6146	IN	denotes	unlike
T24695	6138-6139	,	denotes	,
T24694	6136-6138	FW	denotes	se
T24693	6132-6135	IN	denotes	per
T24692	6126-6131	NN	denotes	death
T24691	6121-6125	NN	denotes	cell
T24690	6116-6120	IN	denotes	than
T24689	6109-6115	RB	denotes	rather
T24688	6107-6108	,	denotes	,
T24687	6098-6107	NN	denotes	synthesis
T24686	6093-6097	NNP	denotes	TNFα
T24685	6090-6092	IN	denotes	in
T24684	6081-6089	NN	denotes	increase
T24683	6078-6080	DT	denotes	an
T24682	6075-6077	TO	denotes	to
T24681	6063-6074	RB	denotes	prominently
T24680	6058-6062	JJR	denotes	more
T24679	6046-6057	VBD	denotes	contributed
T24678	6036-6045	VBG	denotes	signaling
T24677	6032-6035	NNP	denotes	Akt
T24676	6030-6031	,	denotes	,
T24675	6019-6030	NNS	denotes	macrophages
T24674	6015-6018	CC	denotes	and
T24673	6013-6014	,	denotes	,
T24672	6008-6013	NNS	denotes	cells
T24671	6001-6007	NNP	denotes	Jurkat
T24670	5986-6000	JJ	denotes	FADD-deficient
T24669	5984-5985	,	denotes	,
T24668	5973-5984	NNS	denotes	fibroblasts
T23850	1232-1233	DT	denotes	a
T23849	1220-1231	VBG	denotes	identifying
T23848	1212-1219	RB	denotes	thereby
T23847	1210-1211	,	denotes	,
T23846	1199-1210	NN	denotes	necroptosis
T23845	1196-1198	TO	denotes	to
T23844	1184-1195	VBZ	denotes	contributes
T23843	1177-1183	JJ	denotes	mTORC1
T23842	1174-1176	IN	denotes	of
T23841	1163-1173	JJ	denotes	downstream
T23840	1155-1162	NN	denotes	pathway
T23839	1146-1154	NN	denotes	effector
T23838	1142-1145	NNP	denotes	Akt
T23837	1138-1141	DT	denotes	the
T23836	1133-1137	IN	denotes	that
T23835	1126-1132	VBP	denotes	reveal
T23834	1121-1125	NNS	denotes	data
T23833	1117-1120	PRP$	denotes	our
T23832	1113-1116	CC	denotes	and
T23831	1107-1112	NNS	denotes	cells
T23830	1102-1106	NNP	denotes	L929
T23829	1099-1101	IN	denotes	in
T23828	1088-1098	NNS	denotes	substrates
T23827	1082-1087	VBN	denotes	known
T23826	1079-1081	IN	denotes	of
T23825	1072-1078	NN	denotes	number
T24451	4734-4738	IN	denotes	with
T24450	4722-4733	NN	denotes	conjunction
T24449	4719-4721	IN	denotes	in
T24448	4708-4718	VBN	denotes	considered
T24447	4705-4707	VB	denotes	be
T24446	4698-4704	MD	denotes	should
T24445	4693-4697	WDT	denotes	that
T24444	4683-4692	NN	denotes	mechanism
T24443	4675-4682	DT	denotes	Another
T24442	4673-4674	.	denotes	.
T24441	4672-4673	NNP	denotes	]
T24440	4670-4672	CD	denotes	47
T24439	4669-4670	NNP	denotes	[
T24438	4662-4668	NN	denotes	stress
T24437	4652-4661	JJ	denotes	metabolic
T24436	4642-4651	JJ	denotes	excessive
T24435	4639-4641	CC	denotes	or
T24434	4637-4638	NNP	denotes	]
T24433	4635-4637	CD	denotes	45
T24432	4634-4635	NNP	denotes	[
T24431	4626-4633	NNS	denotes	factors
T24430	4616-4625	JJ	denotes	oncogenic
T24429	4605-4615	JJ	denotes	particular
T24428	4602-4604	IN	denotes	of
T24427	4591-4601	NN	denotes	expression
T24426	4589-4590	,	denotes	,
T24425	4583-4589	NN	denotes	kinase
T24424	4578-4582	CD	denotes	RIP1
T24423	4575-4577	IN	denotes	of
T24422	4568-4574	NN	denotes	status
T24421	4564-4567	DT	denotes	the
T24420	4561-4563	IN	denotes	as
T24419	4556-4560	JJ	denotes	such
T24418	4554-4555	,	denotes	,
T24417	4548-4554	NNS	denotes	inputs
T24416	4532-4547	JJ	denotes	Akt-independent
T24415	4530-4531	,	denotes	,
T24414	4520-4530	JJ	denotes	additional
T24413	4517-4519	IN	denotes	on
T24412	4510-4516	VB	denotes	depend
T24411	4506-4509	MD	denotes	may
T24410	4500-4505	NN	denotes	death
T24409	4496-4499	CC	denotes	and
T24408	4487-4495	NN	denotes	survival
T24407	4479-4486	IN	denotes	between
T24406	4470-4478	NN	denotes	decision
T24405	4464-4469	JJ	denotes	final
T24404	4460-4463	DT	denotes	The
T24403	4458-4459	.	denotes	.
T24402	4453-4458	NN	denotes	death
T24401	4448-4452	NN	denotes	cell
T24400	4434-4447	JJ	denotes	non-apoptotic
T24399	4431-4433	TO	denotes	to
T24398	4422-4430	NN	denotes	survival
T24397	4417-4421	IN	denotes	from
T24396	4409-4416	VBG	denotes	ranging
T24395	4407-4408	,	denotes	,
T24394	4398-4407	NN	denotes	apoptosis
T24393	4395-4397	TO	denotes	to
T24392	4383-4394	NN	denotes	alternative
T24391	4377-4382	VBZ	denotes	fates
T24390	4372-4376	NN	denotes	cell
T24389	4364-4371	VB	denotes	promote
T24388	4361-4363	TO	denotes	to
T24387	4352-4360	VB	denotes	function
T24386	4348-4351	MD	denotes	may
T24385	4340-4347	NN	denotes	pathway
T24384	4336-4339	NNP	denotes	Akt
T24383	4332-4335	DT	denotes	the
T24382	4330-4331	,	denotes	,
T24381	4326-4330	NN	denotes	role
T24380	4313-4325	JJ	denotes	pro-survival
T24379	4301-4312	RB	denotes	universally
T24378	4299-4300	DT	denotes	a
T24377	4291-4298	VBG	denotes	serving
T24376	4286-4290	IN	denotes	than
T24375	4279-4285	RB	denotes	rather
T24374	4274-4278	DT	denotes	that
T24373	4264-4273	VB	denotes	speculate
T24372	4261-4263	TO	denotes	to
T24371	4252-4260	JJ	denotes	tempting
T24370	4249-4251	VBZ	denotes	is
T24369	4246-4248	PRP	denotes	It
T24368	4244-4245	.	denotes	.
T24367	4239-4244	NN	denotes	death
T24366	4234-4238	NN	denotes	cell
T24365	4229-4233	JJR	denotes	more
T24364	4226-4228	TO	denotes	to
T24363	4221-4225	VB	denotes	lead
T24362	4216-4220	MD	denotes	will
T24361	4205-4215	NN	denotes	inhibition
T24360	4201-4204	PRP$	denotes	its
T24359	4196-4200	IN	denotes	that
T24358	4192-4195	CC	denotes	nor
T24357	4182-4191	VBG	denotes	signaling
T24356	4169-4181	JJ	denotes	pro-survival
T24355	4160-4168	VBZ	denotes	reflects
T24354	4148-4159	RB	denotes	universally
T24353	4144-4147	NNP	denotes	Akt
T24352	4141-4143	IN	denotes	of
T24351	4130-4140	NN	denotes	activation
T24350	4125-4129	DT	denotes	that
T24349	4118-4124	VB	denotes	assume
T24348	4115-4117	TO	denotes	to
T24347	4110-4114	JJ	denotes	safe
T24346	4107-4109	VB	denotes	be
T24345	4100-4106	RB	denotes	longer
T24344	4097-4099	RB	denotes	no
T24343	4093-4096	MD	denotes	may
T24342	4090-4092	PRP	denotes	it
T24341	4088-4089	,	denotes	,
T24340	4079-4088	RB	denotes	Therefore
T24339	4077-4078	.	denotes	.
T24338	4073-4077	NNP	denotes	MDM2
T24337	4069-4072	CC	denotes	and
T24336	4067-4068	,	denotes	,
T24335	4060-4067	NNP	denotes	FoxO1/4
T24334	4058-4059	,	denotes	,
T24333	4053-4058	NNP	denotes	GSK-3
T24332	4051-4052	,	denotes	,
T24331	4040-4051	RB	denotes	potentially
T24330	4036-4039	CC	denotes	and
T24329	4034-4035	,	denotes	,
T24328	4028-4034	NNP	denotes	mTORC1
T24327	4018-4027	VBG	denotes	including
T24326	4010-4017	NNS	denotes	targets
T24325	4006-4009	NNP	denotes	Akt
T24324	3994-4005	VBN	denotes	established
T24323	3989-3993	RB	denotes	well
T24322	3986-3988	IN	denotes	of
T24321	3979-3985	NN	denotes	number
T24320	3977-3978	DT	denotes	a
T24319	3968-3976	VBZ	denotes	involves
T24230	3482-3488	JJ	denotes	mTORC1
T24229	3477-3481	IN	denotes	that
T24228	3474-3476	VBZ	denotes	is
T24227	3462-3473	NN	denotes	possibility
T24226	3458-3461	CD	denotes	one
T24225	3456-3457	,	denotes	,
T24224	3445-3456	NN	denotes	necroptosis
T24223	3442-3444	IN	denotes	in
T24222	3434-3441	NN	denotes	control
T24221	3420-3433	JJ	denotes	translational
T24220	3403-3419	JJ	denotes	mTORC1-dependent
T24219	3400-3402	IN	denotes	of
T24218	3389-3399	NN	denotes	importance
T24217	3385-3388	DT	denotes	the
T24216	3381-3384	CC	denotes	and
T24215	3376-3380	NNP	denotes	TNFα
T24214	3373-3375	IN	denotes	by
T24213	3369-3372	NNP	denotes	JNK
T24212	3366-3368	IN	denotes	of
T24211	3355-3365	NN	denotes	activation
T24210	3351-3354	DT	denotes	the
T24209	3345-3350	VBN	denotes	Given
T24208	3343-3344	.	denotes	.
T24207	3332-3343	VBN	denotes	established
T24206	3329-3331	VB	denotes	be
T24205	3326-3328	TO	denotes	to
T24204	3319-3325	VBP	denotes	remain
T24203	3307-3318	NN	denotes	necroptosis
T24202	3300-3306	IN	denotes	during
T24201	3289-3299	NNS	denotes	mechanisms
T24200	3283-3288	JJ	denotes	exact
T24199	3279-3282	DT	denotes	the
T24198	3277-3278	,	denotes	,
T24197	3276-3277	NNP	denotes	]
T24196	3274-3276	CD	denotes	46
T24195	3273-3274	NNP	denotes	[
T24194	3266-3272	NN	denotes	stress
T24193	3263-3265	NNP	denotes	ER
T24192	3253-3262	VBG	denotes	following
T24191	3248-3252	FW	denotes	e.g.
T24190	3246-3247	,	denotes	,
T24189	3243-3246	NNP	denotes	JNK
T24188	3240-3242	IN	denotes	of
T24187	3229-3239	NN	denotes	regulation
T24186	3212-3228	JJ	denotes	mTORC1-dependent
T24185	3209-3211	IN	denotes	of
T24184	3200-3208	NNS	denotes	examples
T24183	3193-3199	JJ	denotes	recent
T24182	3188-3192	DT	denotes	some
T24181	3184-3187	VBP	denotes	are
T24180	3178-3183	EX	denotes	there
T24179	3172-3177	IN	denotes	While
T24178	3170-3171	.	denotes	.
T24177	3160-3170	VBN	denotes	elucidated
T24176	3157-3159	VB	denotes	be
T24175	3154-3156	TO	denotes	to
T24174	3147-3153	VBP	denotes	remain
T24173	3143-3146	NNP	denotes	JNK
T24172	3140-3142	TO	denotes	to
T24171	3133-3139	NNP	denotes	mTORC1
T24170	3122-3132	VBG	denotes	connecting
T24169	3111-3121	NNS	denotes	mechanisms
T24168	3107-3110	DT	denotes	the
T24167	3105-3106	,	denotes	,
T24166	3096-3105	RB	denotes	Similarly
T24165	3094-3095	.	denotes	.
T24164	3083-3094	VBN	denotes	established
T24163	3078-3082	VBN	denotes	been
T24162	3073-3077	VBP	denotes	have
T24161	3061-3072	NNS	denotes	connections
T24160	3056-3060	JJ	denotes	such
T24159	3053-3055	DT	denotes	no
T24158	3047-3052	IN	denotes	since
T24157	3045-3046	,	denotes	,
T24156	3040-3045	NN	denotes	death
T24155	3028-3039	JJ	denotes	necroptotic
T24154	3025-3027	IN	denotes	in
T24153	3014-3024	NNS	denotes	substrates
T24152	3010-3013	NNP	denotes	Akt
T24151	2999-3009	JJ	denotes	additional
T24150	2996-2998	IN	denotes	of
T24149	2990-2995	NNS	denotes	roles
T24148	2986-2989	DT	denotes	the
T24147	2983-2985	IN	denotes	of
T24146	2969-2982	NN	denotes	re-evaluation
T24145	2967-2968	DT	denotes	a
T24144	2958-2966	VBZ	denotes	warrants
T24143	2953-2957	DT	denotes	This
T24142	2951-2952	.	denotes	.
T24141	2943-2951	VBN	denotes	involved
T24140	2940-2942	VB	denotes	be
T24139	2937-2939	TO	denotes	to
T24138	2930-2936	JJ	denotes	likely
T24137	2926-2929	VBP	denotes	are
T24136	2915-2925	NNS	denotes	substrates
T24135	2911-2914	NNP	denotes	Akt
T24134	2900-2910	JJ	denotes	additional
T24133	2895-2899	IN	denotes	that
T24132	2884-2894	VBG	denotes	suggesting
T24131	2882-2883	,	denotes	,
T24130	2872-2882	NNS	denotes	conditions
T24129	2860-2871	JJ	denotes	necroptotic
T24128	2854-2859	IN	denotes	under
T24127	2845-2853	NN	denotes	activity
T24126	2838-2844	JJ	denotes	mTORC1
T24125	2835-2837	IN	denotes	in
T24124	2827-2834	NNS	denotes	changes
T24123	2820-2826	JJ	denotes	modest
T24122	2815-2819	RB	denotes	only
T24121	2806-2814	VBN	denotes	observed
T24120	2801-2805	VBP	denotes	have
T24119	2798-2800	PRP	denotes	we
T24118	2796-2797	,	denotes	,
T24117	2792-2796	NN	denotes	hand
T24116	2786-2791	JJ	denotes	other
T24115	2782-2785	DT	denotes	the
T24114	2779-2781	IN	denotes	On
T24113	2777-2778	.	denotes	.
T24112	2770-2777	NN	denotes	control
T24111	2758-2769	JJ	denotes	necroptotic
T24110	2755-2757	IN	denotes	in
T24109	2748-2754	NNP	denotes	mTORC1
T24108	2745-2747	IN	denotes	by
T24107	2736-2744	VBN	denotes	mediated
T24106	2727-2735	NNS	denotes	pathways
T24105	2718-2726	NN	denotes	effector
T24104	2714-2717	NNP	denotes	Akt
T24103	2710-2713	IN	denotes	for
T24102	2704-2709	NNS	denotes	roles
T24101	2700-2703	JJ	denotes	new
T24100	2692-2699	VBP	denotes	suggest
T24099	2687-2691	NNS	denotes	data
T24098	2683-2686	PRP$	denotes	our
T24097	2681-2682	,	denotes	,
T24096	2677-2681	NN	denotes	hand
T24095	2673-2676	CD	denotes	one
T24094	2669-2672	DT	denotes	the
T24093	2666-2668	IN	denotes	On
T24092	2664-2665	.	denotes	?
T24091	2655-2664	NN	denotes	synthesis
T24090	2650-2654	NNP	denotes	TNFα
T24089	2646-2649	CC	denotes	and
T24088	2640-2645	NN	denotes	death
T24087	2631-2639	JJ	denotes	necrotic
T24086	2623-2630	VBP	denotes	promote
T24085	2618-2622	WDT	denotes	that
T24084	2614-2617	NNP	denotes	Akt
T24083	2611-2613	IN	denotes	of
T24082	2600-2610	NNS	denotes	substrates
T24081	2596-2599	JJ	denotes	key
T24080	2592-2595	DT	denotes	the
T24079	2588-2591	VBP	denotes	are
T24078	2583-2587	WDT	denotes	what
T24077	2581-2582	,	denotes	,
T24076	2575-2581	NNP	denotes	Second
T24075	2573-2574	.	denotes	.
T24074	2563-2573	NN	denotes	regulation
T24073	2552-2562	JJ	denotes	endogenous
T24072	2544-2551	VB	denotes	reflect
T24071	2540-2543	RB	denotes	not
T24070	2535-2539	VBZ	denotes	does
T24069	2531-2534	CC	denotes	and
T24068	2522-2530	NN	denotes	artifact
T24067	2516-2521	NN	denotes	vitro
T24066	2513-2515	IN	denotes	in
T24065	2510-2512	DT	denotes	an
T24064	2499-2509	VBZ	denotes	represents
T24063	2492-2498	JJ	denotes	likely
T24062	2487-2491	NNP	denotes	RIP1
T24061	2484-2486	IN	denotes	by
T24060	2480-2483	NNP	denotes	Akt
T24059	2477-2479	IN	denotes	of
T24058	2461-2476	NN	denotes	phosphorylation
T24057	2454-2460	JJ	denotes	direct
T24056	2449-2453	IN	denotes	that
T24055	2438-2448	VBG	denotes	suggesting
T24054	2436-2437	,	denotes	,
T24053	2429-2436	NN	denotes	peptide
T24052	2422-2428	NNP	denotes	Thr435
T24051	2414-2421	IN	denotes	against
T24050	2407-2413	VBN	denotes	raised
T24049	2398-2406	NN	denotes	antibody
T24048	2381-2397	JJ	denotes	phospho-specific
T24047	2379-2380	DT	denotes	a
T24046	2374-2378	IN	denotes	with
T24045	2365-2373	VBG	denotes	blotting
T24044	2357-2364	JJ	denotes	western
T24043	2354-2356	CC	denotes	or
T24042	2341-2353	NN	denotes	spectrometry
T24041	2336-2340	NN	denotes	mass
T24318	3960-3967	RB	denotes	clearly
T24317	3949-3959	NN	denotes	regulation
T24316	3944-3948	DT	denotes	this
T24315	3942-3943	,	denotes	,
T24314	3937-3942	VBP	denotes	exist
T24313	3933-3936	NNP	denotes	Akt
T24312	3930-3932	IN	denotes	of
T24311	3922-3929	NNS	denotes	targets
T24310	3901-3921	JJ	denotes	necroptosis-specific
T24309	3896-3900	IN	denotes	that
T24308	3887-3895	JJ	denotes	possible
T24307	3884-3886	VBZ	denotes	is
T24306	3881-3883	PRP	denotes	it
T24305	3875-3880	IN	denotes	while
T24304	3873-3874	,	denotes	,
T24303	3862-3873	RB	denotes	Importantly
T24302	3860-3861	.	denotes	.
T24301	3854-3860	NN	denotes	kinase
T24300	3849-3853	NNP	denotes	RIP1
T24299	3846-3848	IN	denotes	by
T24298	3842-3845	NNP	denotes	Akt
T24297	3839-3841	IN	denotes	of
T24296	3828-3838	NN	denotes	regulation
T24295	3810-3827	JJ	denotes	necrosis-specific
T24294	3807-3809	IN	denotes	of
T24293	3802-3806	NN	denotes	mode
T24292	3798-3801	JJ	denotes	new
T24291	3796-3797	DT	denotes	a
T24290	3783-3795	VBZ	denotes	demonstrates
T24289	3778-3782	NNS	denotes	data
T24288	3774-3777	PRP$	denotes	Our
T24287	3772-3773	.	denotes	.
T24286	3771-3772	NNP	denotes	]
T24285	3769-3771	CD	denotes	47
T24284	3768-3769	NNP	denotes	[
T24283	3766-3767	,	denotes	,
T24282	3765-3766	NN	denotes	]
T24281	3763-3765	CD	denotes	45
T24280	3762-3763	JJ	denotes	[
T24279	3757-3761	RB	denotes	well
T24278	3754-3756	RB	denotes	as
T24277	3747-3753	VB	denotes	emerge
T24276	3744-3746	TO	denotes	to
T24275	3738-3743	VBN	denotes	begun
T24274	3734-3737	VBZ	denotes	has
T24273	3720-3733	NNS	denotes	circumstances
T24272	3712-3719	JJ	denotes	various
T24271	3706-3711	IN	denotes	under
T24270	3700-3705	NN	denotes	death
T24269	3695-3699	NN	denotes	cell
T24268	3692-3694	IN	denotes	of
T24267	3683-3691	NN	denotes	mediator
T24266	3681-3682	DT	denotes	a
T24265	3678-3680	IN	denotes	as
T24264	3665-3677	NN	denotes	contribution
T24263	3661-3664	PRP$	denotes	its
T24262	3658-3660	IN	denotes	of
T24261	3649-3657	NN	denotes	evidence
T24260	3647-3648	,	denotes	,
T24259	3640-3647	RB	denotes	however
T24258	3638-3639	,	denotes	,
T24257	3628-3638	VBN	denotes	documented
T24256	3623-3627	RB	denotes	well
T24255	3620-3622	VBZ	denotes	is
T24254	3610-3619	NN	denotes	apoptosis
T24253	3607-3609	IN	denotes	of
T24252	3597-3606	NN	denotes	inhibitor
T24251	3593-3596	JJ	denotes	key
T24250	3591-3592	DT	denotes	a
T24249	3588-3590	IN	denotes	as
T24248	3583-3587	NN	denotes	role
T24247	3577-3580	NNP	denotes	Akt
T24246	3575-3576	.	denotes	.
T24245	3572-3575	NNP	denotes	JNK
T24244	3567-3571	IN	denotes	with
T24243	3562-3566	NN	denotes	loop
T24242	3554-3561	RB	denotes	forward
T24241	3549-3553	NN	denotes	feed
T24240	3540-3548	JJ	denotes	positive
T24239	3538-3539	DT	denotes	a
T24238	3532-3537	NNS	denotes	forms
T24237	3528-3531	CC	denotes	and
T24236	3523-3527	NNP	denotes	TNFα
T24235	3520-3522	IN	denotes	of
T24234	3508-3519	NN	denotes	translation
T24233	3504-3507	DT	denotes	the
T24232	3501-3503	TO	denotes	to
T24231	3489-3500	VBZ	denotes	contributes
T23824	1070-1071	DT	denotes	a
T23823	1062-1069	IN	denotes	towards
T23822	1053-1061	NN	denotes	activity
T23821	1049-1052	PRP$	denotes	its
T23820	1040-1048	VB	denotes	increase
T23819	1037-1039	TO	denotes	to
T23818	1026-1036	JJ	denotes	sufficient
T23817	1023-1025	VBZ	denotes	is
T23816	1019-1022	NNP	denotes	Akt
T23815	1016-1018	IN	denotes	of
T23814	1009-1015	CD	denotes	Thr308
T23813	1006-1008	IN	denotes	of
T23812	990-1005	NN	denotes	phosphorylation
T23811	978-989	JJ	denotes	Necroptotic
T23810	976-977	.	denotes	.
T23809	967-976	VBG	denotes	signaling
T23808	955-966	JJ	denotes	necroptotic
T23807	951-954	IN	denotes	for
T23806	942-950	VBN	denotes	required
T23805	939-941	VBZ	denotes	is
T23804	934-938	NN	denotes	turn
T23803	931-933	IN	denotes	in
T23802	925-930	WDT	denotes	which
T23801	923-924	,	denotes	,
T23785	824-828	NNP	denotes	TNFα
T23784	820-823	CC	denotes	and
T23783	816-819	NNP	denotes	JNK
T23782	813-815	IN	denotes	of
T23781	802-812	NN	denotes	activation
T23780	792-801	JJ	denotes	efficient
T23779	789-791	CC	denotes	or
T23778	777-788	NN	denotes	necroptosis
T23777	774-776	IN	denotes	of
T23776	764-773	NN	denotes	induction
T23775	760-763	DT	denotes	the
T23774	756-759	IN	denotes	for
T23773	745-755	JJ	denotes	sufficient
T23772	741-744	RB	denotes	not
T23771	738-740	VBZ	denotes	is
T23770	730-737	NNP	denotes	Myr-Akt
T23769	727-729	IN	denotes	of
T23768	716-726	NN	denotes	expression
T23767	714-715	,	denotes	,
T23766	710-714	NN	denotes	time
T23765	705-709	JJ	denotes	same
T23764	701-704	DT	denotes	the
T23763	698-700	IN	denotes	At
T23762	696-697	.	denotes	.
T23761	685-696	NN	denotes	requirement
T23760	680-684	DT	denotes	this
T23759	670-679	VBZ	denotes	overcomes
T23758	662-669	NNP	denotes	Myr-Akt
T23757	644-661	JJ	denotes	membrane-targeted
T23756	637-643	JJ	denotes	active
T23755	622-636	RB	denotes	constitutively
T23754	619-621	IN	denotes	of
T23753	608-618	NN	denotes	Expression
T23752	606-607	.	denotes	.
T23751	603-606	NNP	denotes	Akt
T23750	600-602	IN	denotes	of
T23749	587-599	NN	denotes	localization
T23748	578-586	NN	denotes	membrane
T23747	571-577	NN	denotes	plasma
T23746	567-570	DT	denotes	the
T23745	564-566	TO	denotes	to
T23744	558-563	VBZ	denotes	leads
T23743	556-557	,	denotes	,
T23742	549-556	NNS	denotes	factors
T23741	542-548	NN	denotes	growth
T23740	539-541	IN	denotes	by
T23739	531-538	VBN	denotes	induced
T23738	528-530	VBZ	denotes	is
T23737	522-527	WDT	denotes	which
T23736	520-521	,	denotes	,
T23735	515-520	NN	denotes	input
T23734	509-514	JJ	denotes	first
T23733	505-508	DT	denotes	The
T23732	503-504	.	denotes	.
T23731	496-503	NNS	denotes	signals
T23730	487-495	JJ	denotes	distinct
T23729	483-486	CD	denotes	two
T23728	474-482	VBZ	denotes	requires
T23727	470-473	NNP	denotes	Akt
T23726	467-469	IN	denotes	of
T23725	451-466	NN	denotes	phosphorylation
T23724	449-450	,	denotes	,
T23723	444-449	NN	denotes	model
T23722	440-443	PRP$	denotes	our
T23721	437-439	TO	denotes	to
T23720	427-436	VBG	denotes	According
T23719	425-426	.	denotes	.
T23718	420-425	NN	denotes	death
T23717	415-419	NN	denotes	cell
T23716	406-414	JJ	denotes	eventual
T23715	402-405	CC	denotes	and
T23714	392-401	NN	denotes	synthesis
T23713	387-391	NNP	denotes	TNFα
T23712	377-386	NN	denotes	autocrine
T23711	375-376	,	denotes	,
T23710	365-375	NN	denotes	activation
T23709	361-364	NNP	denotes	JNK
T23708	351-360	VBG	denotes	including
T23707	349-350	,	denotes	,
T23706	344-349	NNS	denotes	cells
T23705	339-343	CD	denotes	L929
T23704	336-338	IN	denotes	in
T23703	324-335	NN	denotes	necroptosis
T23702	317-323	IN	denotes	during
T23701	310-316	NNS	denotes	events
T23700	300-309	NN	denotes	execution
T23699	296-299	CC	denotes	and
T23698	286-295	VBG	denotes	signaling
T23697	275-285	JJ	denotes	downstream
T23696	272-274	TO	denotes	to
T23695	265-271	NN	denotes	kinase
T23694	260-264	CD	denotes	RIP1
T23693	249-259	VBG	denotes	connecting
T23692	244-248	NN	denotes	link
T23691	242-243	DT	denotes	a
T23690	233-241	VBZ	denotes	provides
T23689	228-232	DT	denotes	This
T23688	226-227	.	denotes	.
T23687	220-226	NNP	denotes	Thr308
T23686	217-219	IN	denotes	on
T23685	201-216	NN	denotes	phosphorylation
T23684	197-200	NNP	denotes	Akt
T23683	194-196	IN	denotes	in
T23682	185-193	NN	denotes	increase
T23681	175-184	JJ	denotes	selective
T23680	173-174	DT	denotes	a
T23679	163-172	VBG	denotes	promoting
T23678	155-162	IN	denotes	through
T23677	146-154	NN	denotes	activity
T23676	142-145	PRP$	denotes	its
T23675	135-141	VBZ	denotes	exerts
T23674	129-134	WDT	denotes	which
T23673	127-128	,	denotes	,
T23672	121-127	NN	denotes	kinase
T23671	116-120	CD	denotes	RIP1
T23670	111-115	IN	denotes	from
T23669	100-110	JJ	denotes	downstream
T23668	90-99	VBG	denotes	signaling
T23667	86-89	DT	denotes	the
T23666	83-85	IN	denotes	in
T23665	75-82	VBN	denotes	engaged
T23664	62-74	RB	denotes	specifically
T23663	59-61	VBZ	denotes	is
T23662	52-58	NN	denotes	kinase
T23661	48-51	NNP	denotes	Akt
T23660	43-47	IN	denotes	that
T23659	35-42	VBP	denotes	suggest
T23658	27-34	NNS	denotes	results
T23657	23-26	PRP$	denotes	our
T23656	21-22	,	denotes	,
T23655	11-21	RB	denotes	Altogether
T23800	920-923	NNP	denotes	Akt
T23799	917-919	IN	denotes	of
T23798	901-916	NN	denotes	phosphorylation
T23797	894-900	NNP	denotes	Thr308
T23796	890-893	IN	denotes	for
T23795	881-889	VBN	denotes	required
T23794	878-880	VBZ	denotes	is
T23793	872-877	NN	denotes	input
T23792	855-871	JJ	denotes	kinase-dependent
T23791	850-854	JJ	denotes	RIP1
T23790	848-849	,	denotes	,
T23789	842-848	JJ	denotes	second
T23788	840-841	DT	denotes	A
T23787	838-839	.	denotes	.
T23786	829-838	NN	denotes	synthesis
T25062	8205-8210	VB	denotes	offer
T25061	8201-8204	MD	denotes	may
T25060	8190-8200	NNS	denotes	inhibitors
T25064	8223-8230	NN	denotes	benefit
T25063	8211-8222	JJ	denotes	therapeutic
T25059	8183-8189	NN	denotes	kinase
T25058	8178-8182	NNP	denotes	RIP1
T25057	8169-8177	JJ	denotes	specific
T25056	8165-8168	CC	denotes	and
T25055	8155-8164	JJ	denotes	efficient
T25054	8152-8154	IN	denotes	as
T25053	8150-8151	,	denotes	,
T25052	8137-8150	NN	denotes	investigation
T25051	8129-8136	RBR	denotes	further
T25050	8120-8128	NNS	denotes	warrants
T25049	8111-8119	NNS	denotes	diseases
T25048	8098-8110	JJ	denotes	inflammatory
T25047	8090-8097	JJ	denotes	chronic
T25046	8086-8089	CC	denotes	and
T25045	8080-8085	JJ	denotes	acute
T25044	8077-8079	IN	denotes	in
T25043	8070-8076	NN	denotes	kinase
T25042	8065-8069	CD	denotes	RIP1
T25041	8062-8064	IN	denotes	of
T25040	8057-8061	NN	denotes	role
T25039	8053-8056	DT	denotes	The
T25038	8051-8052	.	denotes	.
T25037	8050-8051	NNP	denotes	]
T25036	8049-8050	CD	denotes	6
T25035	8048-8049	NN	denotes	[
T25034	8043-8047	NNP	denotes	SIRS
T25033	8031-8042	JJ	denotes	TNF-induced
T25032	8028-8030	IN	denotes	by
T25031	8017-8027	VBN	denotes	introduced
T25030	8010-8016	NN	denotes	damage
T25029	8001-8009	JJ	denotes	cellular
T25028	7997-8000	DT	denotes	the
T25027	7989-7996	VBP	denotes	mediate
T25026	7984-7988	CD	denotes	RIP3
T25025	7980-7983	CC	denotes	and
T25024	7975-7979	CD	denotes	RIP1
T25023	7970-7974	IN	denotes	that
T25022	7964-7969	VBN	denotes	shown
T25021	7960-7963	VBZ	denotes	has
T25020	7956-7959	FW	denotes	al.
T25019	7953-7955	FW	denotes	et
T25018	7946-7952	NNP	denotes	Duprez
T25017	7943-7945	IN	denotes	by
R15684	T23655	T23659	advmod	Altogether,suggest
R15685	T23656	T23659	punct	",",suggest
R15686	T23657	T23658	poss	our,results
R15687	T23658	T23659	nsubj	results,suggest
R15688	T23659	T23659	ROOT	suggest,suggest
R15689	T23660	T23665	mark	that,engaged
R15690	T23661	T23662	compound	Akt,kinase
R15691	T23662	T23665	nsubjpass	kinase,engaged
R15692	T23663	T23665	auxpass	is,engaged
R15693	T23664	T23665	advmod	specifically,engaged
R15694	T23665	T23659	ccomp	engaged,suggest
R15695	T23666	T23665	prep	in,engaged
R15696	T23667	T23669	det	the,downstream
R15697	T23668	T23669	amod	signaling,downstream
R15698	T23669	T23666	pobj	downstream,in
R15699	T23670	T23665	prep	from,engaged
R15700	T23671	T23672	nummod	RIP1,kinase
R15701	T23672	T23670	pobj	kinase,from
R15702	T23673	T23672	punct	",",kinase
R15703	T23674	T23675	nsubj	which,exerts
R15704	T23675	T23672	relcl	exerts,kinase
R15705	T23676	T23677	poss	its,activity
R15706	T23677	T23675	dobj	activity,exerts
R15707	T23678	T23675	prep	through,exerts
R15708	T23679	T23678	pcomp	promoting,through
R15709	T23680	T23682	det	a,increase
R15710	T23681	T23682	amod	selective,increase
R15711	T23682	T23679	dobj	increase,promoting
R15712	T23683	T23682	prep	in,increase
R15713	T23684	T23685	compound	Akt,phosphorylation
R15714	T23685	T23683	pobj	phosphorylation,in
R15715	T23686	T23682	prep	on,increase
R15716	T23687	T23686	pobj	Thr308,on
R15717	T23688	T23659	punct	.,suggest
R15718	T23689	T23690	nsubj	This,provides
R15719	T23690	T23690	ROOT	provides,provides
R15720	T23691	T23692	det	a,link
R15721	T23692	T23701	nmod	link,events
R15722	T23693	T23692	acl	connecting,link
R15723	T23694	T23695	nummod	RIP1,kinase
R15724	T23695	T23693	dobj	kinase,connecting
R15725	T23696	T23693	prep	to,connecting
R15726	T23697	T23698	amod	downstream,signaling
R15727	T23698	T23696	pobj	signaling,to
R15728	T23699	T23698	cc	and,signaling
R15729	T23700	T23701	compound	execution,events
R15730	T23701	T23690	dobj	events,provides
R15731	T23702	T23690	prep	during,provides
R15732	T23703	T23702	pobj	necroptosis,during
R15733	T23704	T23703	prep	in,necroptosis
R15734	T23705	T23706	nummod	L929,cells
R15735	T23706	T23704	pobj	cells,in
R15736	T23707	T23703	punct	",",necroptosis
R15737	T23708	T23703	prep	including,necroptosis
R15738	T23709	T23710	compound	JNK,activation
R15739	T23710	T23708	pobj	activation,including
R15740	T23711	T23710	punct	",",activation
R15741	T23712	T23714	compound	autocrine,synthesis
R15742	T23713	T23714	compound	TNFα,synthesis
R15743	T23714	T23710	conj	synthesis,activation
R15744	T23715	T23714	cc	and,synthesis
R15745	T23716	T23718	amod	eventual,death
R15746	T23717	T23718	compound	cell,death
R15747	T23718	T23714	conj	death,synthesis
R15748	T23719	T23690	punct	.,provides
R15749	T23720	T23728	csubj	According,requires
R15750	T23721	T23720	prep	to,According
R15751	T23722	T23723	poss	our,model
R15752	T23723	T23721	pobj	model,to
R15753	T23724	T23723	punct	",",model
R15754	T23725	T23723	conj	phosphorylation,model
R15755	T23726	T23723	prep	of,model
R15756	T23727	T23726	pobj	Akt,of
R15757	T23728	T23728	ROOT	requires,requires
R15758	T23729	T23731	nummod	two,signals
R15759	T23730	T23731	amod	distinct,signals
R15760	T23731	T23728	dobj	signals,requires
R15761	T23732	T23728	punct	.,requires
R15762	T23733	T23735	det	The,input
R15763	T23734	T23735	amod	first,input
R15764	T23735	T23744	nsubj	input,leads
R15765	T23736	T23735	punct	",",input
R15766	T23737	T23739	nsubjpass	which,induced
R15767	T23738	T23739	auxpass	is,induced
R15768	T23739	T23735	relcl	induced,input
R15769	T23740	T23739	agent	by,induced
R15770	T23741	T23742	compound	growth,factors
R15771	T23742	T23740	pobj	factors,by
R15772	T23743	T23735	punct	",",input
R15773	T23744	T23744	ROOT	leads,leads
R15774	T23745	T23744	prep	to,leads
R15775	T23746	T23749	det	the,localization
R15776	T23747	T23749	amod	plasma,localization
R15777	T23748	T23749	compound	membrane,localization
R15778	T23749	T23745	pobj	localization,to
R15779	T23750	T23749	prep	of,localization
R15780	T23751	T23750	pobj	Akt,of
R15781	T23752	T23744	punct	.,leads
R15782	T23753	T23759	nsubj	Expression,overcomes
R15783	T23754	T23753	prep	of,Expression
R15784	T23755	T23756	advmod	constitutively,active
R15785	T23756	T23758	amod	active,Myr-Akt
R15786	T23757	T23758	compound	membrane-targeted,Myr-Akt
R15787	T23758	T23754	pobj	Myr-Akt,of
R15788	T23759	T23759	ROOT	overcomes,overcomes
R15789	T23760	T23761	det	this,requirement
R15790	T23761	T23759	dobj	requirement,overcomes
R15791	T23762	T23759	punct	.,overcomes
R15792	T23763	T23771	prep	At,is
R15793	T23764	T23766	det	the,time
R15794	T23765	T23766	amod	same,time
R15795	T23766	T23763	pobj	time,At
R15796	T23767	T23771	punct	",",is
R15797	T23768	T23771	nsubj	expression,is
R15798	T23769	T23768	prep	of,expression
R15799	T23770	T23769	pobj	Myr-Akt,of
R15800	T23771	T23771	ROOT	is,is
R15801	T23772	T23771	neg	not,is
R15802	T23773	T23771	acomp	sufficient,is
R15803	T23774	T23773	prep	for,sufficient
R15804	T23775	T23776	det	the,induction
R15805	T23776	T23774	pobj	induction,for
R15806	T23777	T23776	prep	of,induction
R15807	T23778	T23777	pobj	necroptosis,of
R15808	T23779	T23778	cc	or,necroptosis
R15809	T23780	T23781	amod	efficient,activation
R15810	T23781	T23778	conj	activation,necroptosis
R15811	T23782	T23781	prep	of,activation
R15812	T23783	T23782	pobj	JNK,of
R15813	T23784	T23783	cc	and,JNK
R15814	T23785	T23786	compound	TNFα,synthesis
R15815	T23786	T23781	conj	synthesis,activation
R15816	T23787	T23771	punct	.,is
R15817	T23788	T23793	det	A,input
R15818	T23789	T23793	amod	second,input
R15819	T23790	T23793	punct	",",input
R15820	T23791	T23793	amod	RIP1,input
R15821	T23792	T23793	amod	kinase-dependent,input
R15822	T23793	T23795	nsubjpass	input,required
R15823	T23794	T23795	auxpass	is,required
R15824	T23795	T23795	ROOT	required,required
R15825	T23796	T23795	prep	for,required
R15826	T23797	T23798	compound	Thr308,phosphorylation
R15827	T23798	T23796	pobj	phosphorylation,for
R15828	T23799	T23798	prep	of,phosphorylation
R15829	T23800	T23799	pobj	Akt,of
R15830	T23801	T23800	punct	",",Akt
R15831	T23802	T23806	nsubjpass	which,required
R15832	T23803	T23806	prep	in,required
R15833	T23804	T23803	pobj	turn,in
R15834	T23805	T23806	auxpass	is,required
R15835	T23806	T23795	advcl	required,required
R15836	T23807	T23806	prep	for,required
R15837	T23808	T23809	amod	necroptotic,signaling
R15838	T23809	T23807	pobj	signaling,for
R15839	T23810	T23795	punct	.,required
R15840	T23811	T23812	amod	Necroptotic,phosphorylation
R15841	T23812	T23817	nsubj	phosphorylation,is
R15842	T23813	T23812	prep	of,phosphorylation
R15843	T23814	T23813	pobj	Thr308,of
R15844	T23815	T23814	prep	of,Thr308
R15845	T23816	T23815	pobj	Akt,of
R15846	T23817	T23817	ROOT	is,is
R15847	T23818	T23817	acomp	sufficient,is
R15848	T23819	T23820	aux	to,increase
R15849	T23820	T23818	xcomp	increase,sufficient
R15850	T23821	T23822	poss	its,activity
R15851	T23822	T23820	dobj	activity,increase
R15852	T23823	T23820	prep	towards,increase
R15853	T23824	T23825	det	a,number
R15854	T23825	T23823	pobj	number,towards
R15855	T23826	T23825	prep	of,number
R15856	T23827	T23828	amod	known,substrates
R15857	T23828	T23826	pobj	substrates,of
R15858	T23829	T23828	prep	in,substrates
R15859	T23830	T23831	compound	L929,cells
R15860	T23831	T23829	pobj	cells,in
R15861	T23832	T23831	cc	and,cells
R15862	T23833	T23834	poss	our,data
R15863	T23834	T23831	conj	data,cells
R15864	T23835	T23820	dep	reveal,increase
R15865	T23836	T23844	mark	that,contributes
R15866	T23837	T23840	det	the,pathway
R15867	T23838	T23840	nmod	Akt,pathway
R15868	T23839	T23840	compound	effector,pathway
R15869	T23840	T23844	nsubj	pathway,contributes
R15870	T23841	T23844	nsubj	downstream,contributes
R15871	T23842	T23841	prep	of,downstream
R15872	T23843	T23842	pobj	mTORC1,of
R15873	T23844	T23835	ccomp	contributes,reveal
R15874	T23845	T23844	prep	to,contributes
R15875	T23846	T23845	pobj	necroptosis,to
R15876	T23847	T23835	punct	",",reveal
R15877	T23848	T23849	advmod	thereby,identifying
R15878	T23849	T23820	advcl	identifying,increase
R15879	T23850	T23852	det	a,mediator
R15880	T23851	T23852	amod	new,mediator
R15881	T23852	T23849	dobj	mediator,identifying
R15882	T23853	T23852	prep	of,mediator
R15883	T23854	T23855	det	this,form
R15884	T23855	T23853	pobj	form,of
R15885	T23856	T23855	prep	of,form
R15886	T23857	T23858	compound	cell,death
R15887	T23858	T23856	pobj	death,of
R15888	T23859	T23817	punct	.,is
R15889	T23860	T23861	poss	Our,results
R15890	T23861	T23862	nsubj	results,raise
R15891	T23862	T23862	ROOT	raise,raise
R15892	T23863	T23866	det	some,questions
R15893	T23864	T23866	amod	important,questions
R15894	T23865	T23866	amod	mechanistic,questions
R15895	T23866	T23862	dobj	questions,raise
R15896	T23867	T23866	amod	relevant,questions
R15897	T23868	T23867	prep	to,relevant
R15898	T23869	T23871	det	the,regulation
R15899	T23870	T23871	amod	specific,regulation
R15900	T23871	T23868	pobj	regulation,to
R15901	T23872	T23871	prep	of,regulation
R15902	T23873	T23872	pobj	Akt,of
R15903	T23874	T23871	prep	during,regulation
R15904	T23875	T23874	pobj	necroptosis,during
R15905	T23876	T23862	punct	.,raise
R15906	T23877	T23880	advmod	First,is
R15907	T23878	T23880	punct	",",is
R15908	T23879	T23880	attr	what,is
R15909	T23880	T23880	ROOT	is,is
R15910	T23881	T23882	det	the,mechanism
R15911	T23882	T23880	attr	mechanism,is
R15912	T23883	T23882	prep	of,mechanism
R15913	T23884	T23886	det	the,increase
R15914	T23885	T23886	amod	RIP1-dependent,increase
R15915	T23886	T23883	pobj	increase,of
R15916	T23887	T23886	prep	in,increase
R15917	T23888	T23890	compound	Akt,phosphorylation
R15918	T23889	T23890	compound	Thr308,phosphorylation
R15919	T23890	T23887	pobj	phosphorylation,in
R15920	T23891	T23880	punct	?,is
R15921	T23892	T23893	nummod	One,possibility
R15922	T23893	T23894	nsubj	possibility,is
R15923	T23894	T23894	ROOT	is,is
R15924	T23895	T23898	mark	that,inhibits
R15925	T23896	T23897	nummod	RIP1,kinase
R15926	T23897	T23898	nsubj	kinase,inhibits
R15927	T23898	T23894	ccomp	inhibits,is
R15928	T23899	T23900	det	a,phosphatase
R15929	T23900	T23898	dobj	phosphatase,inhibits
R15930	T23901	T23902	nsubj	that,targets
R15931	T23902	T23900	relcl	targets,phosphatase
R15932	T23903	T23902	dobj	Thr308,targets
R15933	T23904	T23894	punct	.,is
R15934	T23905	T23910	prep	To,is
R15935	T23906	T23907	poss	our,knowledge
R15936	T23907	T23905	pobj	knowledge,To
R15937	T23908	T23910	punct	",",is
R15938	T23909	T23910	nsubj	PP2A,is
R15939	T23910	T23910	ROOT	is,is
R15940	T23911	T23913	det	the,enzyme
R15941	T23912	T23913	amod	only,enzyme
R15942	T23913	T23910	attr	enzyme,is
R15943	T23914	T23913	acl	established,enzyme
R15944	T23915	T23917	aux	to,dephosphorylate
R15945	T23916	T23917	advmod	specifically,dephosphorylate
R15946	T23917	T23914	advcl	dephosphorylate,established
R15947	T23918	T23919	det	this,residue
R15948	T23919	T23917	dobj	residue,dephosphorylate
R15949	T23920	T23922	nmod	[,]
R15950	T23921	T23922	nummod	45,]
R15951	T23922	T23919	appos	],residue
R15952	T23923	T23910	punct	.,is
R15953	T23924	T23929	advmod	However,observe
R15954	T23925	T23929	punct	",",observe
R15955	T23926	T23929	nsubj	we,observe
R15956	T23927	T23929	aux	did,observe
R15957	T23928	T23929	neg	not,observe
R15958	T23929	T23929	ROOT	observe,observe
R15959	T23930	T23931	det	any,effect
R15960	T23931	T23929	dobj	effect,observe
R15961	T23932	T23931	prep	of,effect
R15962	T23933	T23935	det	the,inhibitor
R15963	T23934	T23935	compound	PP2A,inhibitor
R15964	T23935	T23932	pobj	inhibitor,of
R15965	T23936	T23931	punct	",",effect
R15966	T23937	T23938	amod	okadaic,acid
R15967	T23938	T23929	dobj	acid,observe
R15968	T23939	T23929	punct	",",observe
R15969	T23940	T23929	prep	on,observe
R15970	T23941	T23942	nummod	Thr308,phosphorylation
R15971	T23942	T23940	pobj	phosphorylation,on
R15972	T23943	T23942	cc	or,phosphorylation
R15973	T23944	T23942	conj	activation,phosphorylation
R15974	T23945	T23944	prep	of,activation
R15975	T23946	T23945	pobj	necroptosis,of
R15976	T23947	T23942	prep	in,phosphorylation
R15977	T23948	T23949	nummod	L929,cells
R15978	T23949	T23947	pobj	cells,in
R15979	T23950	T23929	punct	.,observe
R15980	T23951	T23952	det	Another,possibility
R15981	T23952	T23953	nsubj	possibility,is
R15982	T23953	T23953	ROOT	is,is
R15983	T23954	T23953	attr	that,is
R15984	T23955	T23956	det	the,increase
R15985	T23956	T23954	nsubj	increase,that
R15986	T23957	T23956	prep	in,increase
R15987	T23958	T23959	nummod	Thr308,results
R15988	T23959	T23957	pobj	results,in
R15989	T23960	T23956	prep	from,increase
R15990	T23961	T23962	nummod	RIP1,kinase
R15991	T23962	T23960	pobj	kinase,from
R15992	T23963	T23956	acl	targeting,increase
R15993	T23964	T23963	dobj	PDK1,targeting
R15994	T23965	T23964	punct	",",PDK1
R15995	T23966	T23964	conj	Akt,PDK1
R15996	T23967	T23963	cc	or,targeting
R15997	T23968	T23963	conj	scaffolding,targeting
R15998	T23969	T23968	dobj	factors,scaffolding
R15999	T23970	T23971	nsubj	that,bring
R16000	T23971	T23969	relcl	bring,factors
R16001	T23972	T23974	det	these,kinases
R16002	T23973	T23974	nummod	two,kinases
R16003	T23974	T23971	dobj	kinases,bring
R16004	T23975	T23971	advmod	together,bring
R16005	T23976	T23953	punct	.,is
R16006	T23977	T23980	advmod	Interestingly,observed
R16007	T23978	T23980	punct	",",observed
R16008	T23979	T23980	nsubj	we,observed
R16009	T23980	T23980	ROOT	observed,observed
R16010	T23981	T23980	dobj	phosphorylation,observed
R16011	T23982	T23981	prep	of,phosphorylation
R16012	T23983	T23982	pobj	Akt,of
R16013	T23984	T23981	prep	by,phosphorylation
R16014	T23985	T23987	amod	recombinant,kinase
R16015	T23986	T23987	compound	RIP1,kinase
R16016	T23987	T23984	pobj	kinase,by
R16017	T23988	T23980	prep	in,observed
R16018	T23989	T23988	pobj	vitro,in
R16019	T23990	T23980	prep	on,observed
R16020	T23991	T23990	pobj	Thr146,on
R16021	T23992	T23991	punct	",",Thr146
R16022	T23993	T23991	appos	195/197,Thr146
R16023	T23994	T23991	punct	",",Thr146
R16024	T23995	T23991	cc	and,Thr146
R16025	T23996	T23999	nummod	435,residues
R16026	T23997	T23996	cc	and,435
R16027	T23998	T23996	conj	Ser381,435
R16028	T23999	T23991	conj	residues,Thr146
R16029	T24000	T23980	punct	.,observed
R16030	T24001	T24010	advmod	Furthermore,leads
R16031	T24002	T24010	punct	",",leads
R16032	T24003	T24010	csubj	mutating,leads
R16033	T24004	T24005	det	these,residues
R16034	T24005	T24003	dobj	residues,mutating
R16035	T24006	T24003	prep	to,mutating
R16036	T24007	T24006	pobj	Ala,to
R16037	T24008	T24007	prep	in,Ala
R16038	T24009	T24008	pobj	Myr-Akt,in
R16039	T24010	T24010	ROOT	leads,leads
R16040	T24011	T24010	prep	to,leads
R16041	T24012	T24013	det	the,loss
R16042	T24013	T24011	pobj	loss,to
R16043	T24014	T24013	prep	of,loss
R16044	T24015	T24016	poss	its,ability
R16045	T24016	T24014	pobj	ability,of
R16046	T24017	T24018	aux	to,promote
R16047	T24018	T24016	acl	promote,ability
R16048	T24019	T24018	dobj	necroptosis,promote
R16049	T24020	T24010	punct	.,leads
R16050	T24021	T24024	advmod	However,were
R16051	T24022	T24024	punct	",",were
R16052	T24023	T24024	nsubj	we,were
R16053	T24024	T24024	ROOT	were,were
R16054	T24025	T24024	neg	not,were
R16055	T24026	T24024	acomp	able,were
R16056	T24027	T24028	aux	to,confirm
R16057	T24028	T24026	xcomp	confirm,able
R16058	T24029	T24028	dobj	phosphorylation,confirm
R16059	T24030	T24029	prep	of,phosphorylation
R16060	T24031	T24032	det	these,residues
R16061	T24032	T24030	pobj	residues,of
R16062	T24033	T24029	prep	on,phosphorylation
R16063	T24034	T24035	compound	endogenous,Akt
R16064	T24035	T24033	pobj	Akt,on
R16065	T24036	T24035	prep	in,Akt
R16066	T24037	T24038	compound	L929,cells
R16067	T24038	T24036	pobj	cells,in
R16068	T24039	T24028	advcl	using,confirm
R16069	T24040	T24041	preconj	either,mass
R16070	T24041	T24055	nmod	mass,suggesting
R16071	T24042	T24041	amod	spectrometry,mass
R16072	T24043	T24042	cc	or,spectrometry
R16073	T24044	T24042	conj	western,spectrometry
R16074	T24045	T24042	conj	blotting,spectrometry
R16075	T24046	T24045	prep	with,blotting
R16076	T24047	T24049	det	a,antibody
R16077	T24048	T24049	amod	phospho-specific,antibody
R16078	T24049	T24046	pobj	antibody,with
R16079	T24050	T24049	acl	raised,antibody
R16080	T24051	T24050	prep	against,raised
R16081	T24052	T24053	compound	Thr435,peptide
R16082	T24053	T24051	pobj	peptide,against
R16083	T24054	T24045	punct	",",blotting
R16084	T24055	T24024	advcl	suggesting,were
R16085	T24056	T24064	mark	that,represents
R16086	T24057	T24058	amod	direct,phosphorylation
R16087	T24058	T24064	nsubj	phosphorylation,represents
R16088	T24059	T24058	prep	of,phosphorylation
R16089	T24060	T24059	pobj	Akt,of
R16090	T24061	T24058	prep	by,phosphorylation
R16091	T24062	T24061	pobj	RIP1,by
R16092	T24063	T24064	advmod	likely,represents
R16093	T24064	T24055	advcl	represents,suggesting
R16094	T24065	T24066	det	an,in
R16095	T24066	T24064	prep	in,represents
R16096	T24067	T24068	amod	vitro,artifact
R16097	T24068	T24066	pobj	artifact,in
R16098	T24069	T24064	cc	and,represents
R16099	T24070	T24072	aux	does,reflect
R16100	T24071	T24072	neg	not,reflect
R16101	T24072	T24064	conj	reflect,represents
R16102	T24073	T24074	amod	endogenous,regulation
R16103	T24074	T24072	dobj	regulation,reflect
R16104	T24075	T24024	punct	.,were
R16105	T24076	T24079	advmod	Second,are
R16106	T24077	T24079	punct	",",are
R16107	T24078	T24079	attr	what,are
R16108	T24079	T24079	ROOT	are,are
R16109	T24080	T24082	det	the,substrates
R16110	T24081	T24082	amod	key,substrates
R16111	T24082	T24079	attr	substrates,are
R16112	T24083	T24082	prep	of,substrates
R16113	T24084	T24083	pobj	Akt,of
R16114	T24085	T24086	nsubj	that,promote
R16115	T24086	T24082	relcl	promote,substrates
R16116	T24087	T24088	amod	necrotic,death
R16117	T24088	T24086	dobj	death,promote
R16118	T24089	T24082	cc	and,substrates
R16119	T24090	T24091	compound	TNFα,synthesis
R16120	T24091	T24082	conj	synthesis,substrates
R16121	T24092	T24079	punct	?,are
R16122	T24093	T24100	prep	On,suggest
R16123	T24094	T24096	det	the,hand
R16124	T24095	T24096	nummod	one,hand
R16125	T24096	T24093	pobj	hand,On
R16126	T24097	T24100	punct	",",suggest
R16127	T24098	T24099	poss	our,data
R16128	T24099	T24100	nsubj	data,suggest
R16129	T24100	T24100	ROOT	suggest,suggest
R16130	T24101	T24102	amod	new,roles
R16131	T24102	T24100	dobj	roles,suggest
R16132	T24103	T24102	prep	for,roles
R16133	T24104	T24106	nmod	Akt,pathways
R16134	T24105	T24106	compound	effector,pathways
R16135	T24106	T24103	pobj	pathways,for
R16136	T24107	T24106	acl	mediated,pathways
R16137	T24108	T24107	agent	by,mediated
R16138	T24109	T24108	pobj	mTORC1,by
R16139	T24110	T24107	prep	in,mediated
R16140	T24111	T24112	amod	necroptotic,control
R16141	T24112	T24110	pobj	control,in
R16142	T24113	T24100	punct	.,suggest
R16143	T24114	T24121	prep	On,observed
R16144	T24115	T24117	det	the,hand
R16145	T24116	T24117	amod	other,hand
R16146	T24117	T24114	pobj	hand,On
R16147	T24118	T24121	punct	",",observed
R16148	T24119	T24121	nsubj	we,observed
R16149	T24120	T24121	aux	have,observed
R16150	T24121	T24121	ROOT	observed,observed
R16151	T24122	T24124	advmod	only,changes
R16152	T24123	T24124	amod	modest,changes
R16153	T24124	T24121	dobj	changes,observed
R16154	T24125	T24124	prep	in,changes
R16155	T24126	T24127	amod	mTORC1,activity
R16156	T24127	T24125	pobj	activity,in
R16157	T24128	T24121	prep	under,observed
R16158	T24129	T24130	amod	necroptotic,conditions
R16159	T24130	T24128	pobj	conditions,under
R16160	T24131	T24121	punct	",",observed
R16161	T24132	T24121	advcl	suggesting,observed
R16162	T24133	T24137	mark	that,are
R16163	T24134	T24136	amod	additional,substrates
R16164	T24135	T24136	compound	Akt,substrates
R16165	T24136	T24137	nsubj	substrates,are
R16166	T24137	T24132	ccomp	are,suggesting
R16167	T24138	T24137	acomp	likely,are
R16168	T24139	T24141	aux	to,involved
R16169	T24140	T24141	auxpass	be,involved
R16170	T24141	T24138	xcomp	involved,likely
R16171	T24142	T24121	punct	.,observed
R16172	T24143	T24144	nsubj	This,warrants
R16173	T24144	T24144	ROOT	warrants,warrants
R16174	T24145	T24146	det	a,re-evaluation
R16175	T24146	T24144	dobj	re-evaluation,warrants
R16176	T24147	T24146	prep	of,re-evaluation
R16177	T24148	T24149	det	the,roles
R16178	T24149	T24147	pobj	roles,of
R16179	T24150	T24149	prep	of,roles
R16180	T24151	T24153	amod	additional,substrates
R16181	T24152	T24153	compound	Akt,substrates
R16182	T24153	T24150	pobj	substrates,of
R16183	T24154	T24153	prep	in,substrates
R16184	T24155	T24156	amod	necroptotic,death
R16185	T24156	T24154	pobj	death,in
R16186	T24157	T24144	punct	",",warrants
R16187	T24158	T24164	mark	since,established
R16188	T24159	T24161	det	no,connections
R16189	T24160	T24161	amod	such,connections
R16190	T24161	T24164	nsubjpass	connections,established
R16191	T24162	T24164	aux	have,established
R16192	T24163	T24164	auxpass	been,established
R16193	T24164	T24144	advcl	established,warrants
R16194	T24165	T24144	punct	.,warrants
R16195	T24166	T24174	advmod	Similarly,remain
R16196	T24167	T24174	punct	",",remain
R16197	T24168	T24169	det	the,mechanisms
R16198	T24169	T24174	nsubj	mechanisms,remain
R16199	T24170	T24169	acl	connecting,mechanisms
R16200	T24171	T24170	dobj	mTORC1,connecting
R16201	T24172	T24170	prep	to,connecting
R16202	T24173	T24172	pobj	JNK,to
R16203	T24174	T24174	ROOT	remain,remain
R16204	T24175	T24177	aux	to,elucidated
R16205	T24176	T24177	auxpass	be,elucidated
R16206	T24177	T24174	xcomp	elucidated,remain
R16207	T24178	T24174	punct	.,remain
R16208	T24179	T24181	mark	While,are
R16209	T24180	T24181	expl	there,are
R16210	T24181	T24204	advcl	are,remain
R16211	T24182	T24184	det	some,examples
R16212	T24183	T24184	amod	recent,examples
R16213	T24184	T24181	attr	examples,are
R16214	T24185	T24184	prep	of,examples
R16215	T24186	T24187	amod	mTORC1-dependent,regulation
R16216	T24187	T24185	pobj	regulation,of
R16217	T24188	T24187	prep	of,regulation
R16218	T24189	T24188	pobj	JNK,of
R16219	T24190	T24187	punct	",",regulation
R16220	T24191	T24187	conj	e.g.,regulation
R16221	T24192	T24184	acl	following,examples
R16222	T24193	T24194	compound	ER,stress
R16223	T24194	T24192	pobj	stress,following
R16224	T24195	T24197	nmod	[,]
R16225	T24196	T24197	nummod	46,]
R16226	T24197	T24194	dobj	],stress
R16227	T24198	T24197	punct	",",]
R16228	T24199	T24201	det	the,mechanisms
R16229	T24200	T24201	amod	exact,mechanisms
R16230	T24201	T24197	appos	mechanisms,]
R16231	T24202	T24201	prep	during,mechanisms
R16232	T24203	T24202	pobj	necroptosis,during
R16233	T24204	T24204	ROOT	remain,remain
R16234	T24205	T24207	aux	to,established
R16235	T24206	T24207	auxpass	be,established
R16236	T24207	T24204	xcomp	established,remain
R16237	T24208	T24204	punct	.,remain
R16238	T24209	T24228	prep	Given,is
R16239	T24210	T24211	det	the,activation
R16240	T24211	T24209	pobj	activation,Given
R16241	T24212	T24211	prep	of,activation
R16242	T24213	T24212	pobj	JNK,of
R16243	T24214	T24211	prep	by,activation
R16244	T24215	T24214	pobj	TNFα,by
R16245	T24216	T24215	cc	and,TNFα
R16246	T24217	T24218	det	the,importance
R16247	T24218	T24211	conj	importance,activation
R16248	T24219	T24218	prep	of,importance
R16249	T24220	T24222	amod	mTORC1-dependent,control
R16250	T24221	T24222	amod	translational,control
R16251	T24222	T24219	pobj	control,of
R16252	T24223	T24222	prep	in,control
R16253	T24224	T24223	pobj	necroptosis,in
R16254	T24225	T24228	punct	",",is
R16255	T24226	T24227	nummod	one,possibility
R16256	T24227	T24228	nsubj	possibility,is
R16257	T24228	T24228	ROOT	is,is
R16258	T24229	T24231	mark	that,contributes
R16259	T24230	T24231	nsubj	mTORC1,contributes
R16260	T24231	T24228	ccomp	contributes,is
R16261	T24232	T24231	prep	to,contributes
R16262	T24233	T24234	det	the,translation
R16263	T24234	T24232	pobj	translation,to
R16264	T24235	T24234	prep	of,translation
R16265	T24236	T24235	pobj	TNFα,of
R16266	T24237	T24234	cc	and,translation
R16267	T24238	T24234	conj	forms,translation
R16268	T24239	T24241	det	a,feed
R16269	T24240	T24241	amod	positive,feed
R16270	T24241	T24231	dobj	feed,contributes
R16271	T24242	T24243	amod	forward,loop
R16272	T24243	T24241	appos	loop,feed
R16273	T24244	T24241	prep	with,feed
R16274	T24245	T24244	pobj	JNK,with
R16275	T24246	T24228	punct	.,is
R16276	T24247	T24248	poss	Akt,role
R16277	T24248	T24257	nsubjpass	role,documented
R16278	T24249	T24248	prep	as,role
R16279	T24250	T24252	det	a,inhibitor
R16280	T24251	T24252	amod	key,inhibitor
R16281	T24252	T24249	pobj	inhibitor,as
R16282	T24253	T24252	prep	of,inhibitor
R16283	T24254	T24253	pobj	apoptosis,of
R16284	T24255	T24257	auxpass	is,documented
R16285	T24256	T24257	advmod	well,documented
R16286	T24257	T24257	ROOT	documented,documented
R16287	T24258	T24275	punct	",",begun
R16288	T24259	T24275	advmod	however,begun
R16289	T24260	T24275	punct	",",begun
R16290	T24261	T24275	nsubj	evidence,begun
R16291	T24262	T24261	prep	of,evidence
R16292	T24263	T24264	poss	its,contribution
R16293	T24264	T24262	pobj	contribution,of
R16294	T24265	T24261	prep	as,evidence
R16295	T24266	T24267	det	a,mediator
R16296	T24267	T24265	pobj	mediator,as
R16297	T24268	T24267	prep	of,mediator
R16298	T24269	T24270	compound	cell,death
R16299	T24270	T24268	pobj	death,of
R16300	T24271	T24267	prep	under,mediator
R16301	T24272	T24273	amod	various,circumstances
R16302	T24273	T24271	pobj	circumstances,under
R16303	T24274	T24275	aux	has,begun
R16304	T24275	T24257	conj	begun,documented
R16305	T24276	T24277	aux	to,emerge
R16306	T24277	T24275	xcomp	emerge,begun
R16307	T24278	T24279	advmod	as,well
R16308	T24279	T24277	advmod	well,emerge
R16309	T24280	T24282	amod	[,]
R16310	T24281	T24282	nummod	45,]
R16311	T24282	T24277	dobj	],emerge
R16312	T24283	T24282	punct	",",]
R16313	T24284	T24286	nmod	[,]
R16314	T24285	T24286	nummod	47,]
R16315	T24286	T24282	appos	],]
R16316	T24287	T24275	punct	.,begun
R16317	T24288	T24289	poss	Our,data
R16318	T24289	T24290	nsubj	data,demonstrates
R16319	T24290	T24290	ROOT	demonstrates,demonstrates
R16320	T24291	T24293	det	a,mode
R16321	T24292	T24293	amod	new,mode
R16322	T24293	T24290	dobj	mode,demonstrates
R16323	T24294	T24293	prep	of,mode
R16324	T24295	T24296	amod	necrosis-specific,regulation
R16325	T24296	T24294	pobj	regulation,of
R16326	T24297	T24296	prep	of,regulation
R16327	T24298	T24297	pobj	Akt,of
R16328	T24299	T24290	prep	by,demonstrates
R16329	T24300	T24301	compound	RIP1,kinase
R16330	T24301	T24299	pobj	kinase,by
R16331	T24302	T24290	punct	.,demonstrates
R16332	T24303	T24319	advmod	Importantly,involves
R16333	T24304	T24319	punct	",",involves
R16334	T24305	T24307	mark	while,is
R16335	T24306	T24307	nsubj	it,is
R16336	T24307	T24319	advcl	is,involves
R16337	T24308	T24307	acomp	possible,is
R16338	T24309	T24314	mark	that,exist
R16339	T24310	T24311	amod	necroptosis-specific,targets
R16340	T24311	T24314	nsubj	targets,exist
R16341	T24312	T24311	prep	of,targets
R16342	T24313	T24312	pobj	Akt,of
R16343	T24314	T24307	ccomp	exist,is
R16344	T24315	T24319	punct	",",involves
R16345	T24316	T24317	det	this,regulation
R16346	T24317	T24319	nsubj	regulation,involves
R16347	T24318	T24319	advmod	clearly,involves
R16348	T24319	T24319	ROOT	involves,involves
R16349	T24320	T24321	det	a,number
R16350	T24321	T24319	dobj	number,involves
R16351	T24322	T24321	prep	of,number
R16352	T24323	T24324	advmod	well,established
R16353	T24324	T24326	amod	established,targets
R16354	T24325	T24326	compound	Akt,targets
R16355	T24326	T24322	pobj	targets,of
R16356	T24327	T24326	prep	including,targets
R16357	T24328	T24327	pobj	mTORC1,including
R16358	T24329	T24328	punct	",",mTORC1
R16359	T24330	T24328	cc	and,mTORC1
R16360	T24331	T24328	conj	potentially,mTORC1
R16361	T24332	T24328	punct	",",mTORC1
R16362	T24333	T24328	conj	GSK-3,mTORC1
R16363	T24334	T24333	punct	",",GSK-3
R16364	T24335	T24333	conj	FoxO1/4,GSK-3
R16365	T24336	T24335	punct	",",FoxO1/4
R16366	T24337	T24335	cc	and,FoxO1/4
R16367	T24338	T24335	conj	MDM2,FoxO1/4
R16368	T24339	T24319	punct	.,involves
R16369	T24340	T24346	advmod	Therefore,be
R16370	T24341	T24346	punct	",",be
R16371	T24342	T24346	nsubj	it,be
R16372	T24343	T24346	aux	may,be
R16373	T24344	T24345	neg	no,longer
R16374	T24345	T24346	advmod	longer,be
R16375	T24346	T24346	ROOT	be,be
R16376	T24347	T24346	acomp	safe,be
R16377	T24348	T24349	aux	to,assume
R16378	T24349	T24346	xcomp	assume,be
R16379	T24350	T24355	mark	that,reflects
R16380	T24351	T24355	nsubj	activation,reflects
R16381	T24352	T24351	prep	of,activation
R16382	T24353	T24352	pobj	Akt,of
R16383	T24354	T24355	advmod	universally,reflects
R16384	T24355	T24349	ccomp	reflects,assume
R16385	T24356	T24357	advmod	pro-survival,signaling
R16386	T24357	T24355	dobj	signaling,reflects
R16387	T24358	T24357	cc	nor,signaling
R16388	T24359	T24363	mark	that,lead
R16389	T24360	T24361	poss	its,inhibition
R16390	T24361	T24363	nsubj	inhibition,lead
R16391	T24362	T24363	aux	will,lead
R16392	T24363	T24357	conj	lead,signaling
R16393	T24364	T24363	prep	to,lead
R16394	T24365	T24367	amod	more,death
R16395	T24366	T24367	compound	cell,death
R16396	T24367	T24364	pobj	death,to
R16397	T24368	T24346	punct	.,be
R16398	T24369	T24370	nsubj	It,is
R16399	T24370	T24370	ROOT	is,is
R16400	T24371	T24370	acomp	tempting,is
R16401	T24372	T24373	aux	to,speculate
R16402	T24373	T24371	xcomp	speculate,tempting
R16403	T24374	T24373	dobj	that,speculate
R16404	T24375	T24376	advmod	rather,than
R16405	T24376	T24371	prep	than,tempting
R16406	T24377	T24376	pcomp	serving,than
R16407	T24378	T24381	det	a,role
R16408	T24379	T24380	advmod	universally,pro-survival
R16409	T24380	T24381	amod	pro-survival,role
R16410	T24381	T24377	dobj	role,serving
R16411	T24382	T24387	punct	",",function
R16412	T24383	T24385	det	the,pathway
R16413	T24384	T24385	compound	Akt,pathway
R16414	T24385	T24387	nsubj	pathway,function
R16415	T24386	T24387	aux	may,function
R16416	T24387	T24370	ccomp	function,is
R16417	T24388	T24389	aux	to,promote
R16418	T24389	T24387	xcomp	promote,function
R16419	T24390	T24391	compound	cell,fates
R16420	T24391	T24389	dobj	fates,promote
R16421	T24435	T24434	cc	or,]
R16422	T24392	T24387	conj	alternative,function
R16423	T24393	T24394	aux	to,apoptosis
R16424	T24436	T24438	amod	excessive,stress
R16425	T24394	T24392	advcl	apoptosis,alternative
R16426	T24395	T24394	punct	",",apoptosis
R16427	T24437	T24438	amod	metabolic,stress
R16428	T24438	T24434	conj	stress,]
R16429	T24396	T24394	dep	ranging,apoptosis
R16430	T24397	T24396	prep	from,ranging
R16431	T24439	T24441	nmod	[,]
R16432	T24398	T24397	pobj	survival,from
R16433	T24440	T24441	nummod	47,]
R16434	T24399	T24397	prep	to,from
R16435	T24441	T24438	appos	],stress
R16436	T24442	T24412	punct	.,depend
R16437	T24443	T24444	det	Another,mechanism
R16438	T24400	T24402	amod	non-apoptotic,death
R16439	T24444	T24459	nsubj	mechanism,is
R16440	T24445	T24448	nsubjpass	that,considered
R16441	T24446	T24448	aux	should,considered
R16442	T24401	T24402	compound	cell,death
R16443	T24447	T24448	auxpass	be,considered
R16444	T24402	T24399	pobj	death,to
R16445	T24448	T24444	relcl	considered,mechanism
R16446	T24449	T24448	prep	in,considered
R16447	T24450	T24449	pobj	conjunction,in
R16448	T24403	T24370	punct	.,is
R16449	T24451	T24450	prep	with,conjunction
R16450	T24452	T24453	det	the,regulation
R16451	T24453	T24451	pobj	regulation,with
R16452	T24404	T24406	det	The,decision
R16453	T24454	T24453	prep	of,regulation
R16454	T24455	T24456	compound	cell,death
R16455	T24405	T24406	amod	final,decision
R16456	T24456	T24454	pobj	death,of
R16457	T24457	T24453	prep	by,regulation
R16458	T24458	T24457	pobj	Akt,by
R16459	T24406	T24412	nsubj	decision,depend
R16460	T24459	T24459	ROOT	is,is
R16461	T24460	T24459	acomp	autophagy,is
R16462	T24461	T24459	punct	.,is
R16463	T24407	T24406	prep	between,decision
R16464	T24462	T24463	compound	Akt,activation
R16465	T24463	T24464	nsubj	activation,leads
R16466	T24408	T24407	pobj	survival,between
R16467	T24464	T24464	ROOT	leads,leads
R16468	T24465	T24464	prep	to,leads
R16469	T24466	T24467	det	the,inhibition
R16470	T24467	T24465	pobj	inhibition,to
R16471	T24409	T24408	cc	and,survival
R16472	T24468	T24467	prep	of,inhibition
R16473	T24469	T24468	pobj	autophagy,of
R16474	T24470	T24467	prep	through,inhibition
R16475	T24410	T24408	conj	death,survival
R16476	T24471	T24470	pobj	activation,through
R16477	T24472	T24471	prep	of,activation
R16478	T24473	T24474	compound	mTOR,[
R16479	T24474	T24472	pobj	[,of
R16480	T24475	T24476	nummod	48,]
R16481	T24476	T24474	appos	],[
R16482	T24411	T24412	aux	may,depend
R16483	T24477	T24464	punct	.,leads
R16484	T24478	T24479	det	The,role
R16485	T24479	T24487	nsubj	role,is
R16486	T24412	T24412	ROOT	depend,depend
R16487	T24480	T24479	prep	of,role
R16488	T24481	T24480	pobj	autophagy,of
R16489	T24482	T24479	prep	in,role
R16490	T24413	T24412	prep	on,depend
R16491	T24483	T24484	compound	cell,death
R16492	T24484	T24482	pobj	death,in
R16493	T24414	T24417	amod	additional,inputs
R16494	T24485	T24479	prep	in,role
R16495	T24486	T24485	amod	general,in
R16496	T24487	T24487	ROOT	is,is
R16497	T24415	T24417	punct	",",inputs
R16498	T24488	T24489	advmod	very,complex
R16499	T24489	T24487	acomp	complex,is
R16500	T24490	T24487	cc	and,is
R16501	T24416	T24417	amod	Akt-independent,inputs
R16502	T24491	T24494	nsubj	it,promote
R16503	T24492	T24494	aux	can,promote
R16504	T24417	T24413	pobj	inputs,on
R16505	T24493	T24494	dep	both,promote
R16506	T24494	T24487	conj	promote,is
R16507	T24495	T24494	cc	and,promote
R16508	T24418	T24417	punct	",",inputs
R16509	T24496	T24494	conj	inhibit,promote
R16510	T24497	T24496	dobj	necroptosis,inhibit
R16511	T24419	T24420	amod	such,as
R16512	T24498	T24496	prep	in,inhibit
R16513	T24499	T24500	amod	various,situations
R16514	T24500	T24498	pobj	situations,in
R16515	T24420	T24417	prep	as,inputs
R16516	T24501	T24487	punct	.,is
R16517	T24502	T24503	amod	Several,studies
R16518	T24421	T24422	det	the,status
R16519	T24503	T24504	nsubj	studies,suggested
R16520	T24504	T24504	ROOT	suggested,suggested
R16521	T24505	T24509	mark	that,promotes
R16522	T24422	T24420	pobj	status,as
R16523	T24506	T24509	nsubj	activation,promotes
R16524	T24507	T24506	prep	of,activation
R16525	T24508	T24507	pobj	autophagy,of
R16526	T24423	T24422	prep	of,status
R16527	T24509	T24504	ccomp	promotes,suggested
R16528	T24510	T24509	dobj	necroptosis,promotes
R16529	T24511	T24510	acl	induced,necroptosis
R16530	T24512	T24511	agent	by,induced
R16531	T24424	T24425	nummod	RIP1,kinase
R16532	T24513	T24512	pobj	zVAD.fmk,by
R16533	T24514	T24511	prep	in,induced
R16534	T24425	T24423	pobj	kinase,of
R16535	T24515	T24516	compound	L929,cells
R16536	T24516	T24514	pobj	cells,in
R16537	T24517	T24519	compound	[,]
R16538	T24518	T24519	compound	11,]
R16539	T24426	T24425	punct	",",kinase
R16540	T24427	T24425	appos	expression,kinase
R16541	T24519	T24516	appos	],cells
R16542	T24428	T24427	prep	of,expression
R16543	T24520	T24519	punct	",",]
R16544	T24521	T24523	nmod	[,]
R16545	T24429	T24431	amod	particular,factors
R16546	T24522	T24523	nummod	14,]
R16547	T24523	T24519	conj	],]
R16548	T24524	T24504	punct	.,suggested
R16549	T24430	T24431	amod	oncogenic,factors
R16550	T24525	T24534	nsubj	Others,found
R16551	T24526	T24525	punct	",",Others
R16552	T24431	T24428	pobj	factors,of
R16553	T24527	T24525	prep	including,Others
R16554	T24528	T24527	pobj	ourselves,including
R16555	T24432	T24434	nmod	[,]
R16556	T24529	T24527	prep	in,including
R16557	T24530	T24531	amod	unpublished,data
R16558	T24531	T24529	pobj	data,in
R16559	T24433	T24434	nummod	45,]
R16560	T24434	T24427	nmod	],expression
R16561	T24629	T24628	pobj	Akt,to
R16562	T24532	T24525	punct	",",Others
R16563	T24630	T24623	ccomp	is,revealed
R16564	T24533	T24534	aux	have,found
R16565	T24631	T24633	det	a,feature
R16566	T24534	T24534	ROOT	found,found
R16567	T24535	T24539	mark	that,promotes
R16568	T24536	T24539	nsubj	inihibition,promotes
R16569	T24632	T24633	amod	general,feature
R16570	T24537	T24536	prep	of,inihibition
R16571	T24538	T24537	pobj	autophagy,of
R16572	T24539	T24534	ccomp	promotes,found
R16573	T24633	T24630	attr	feature,is
R16574	T24540	T24539	dobj	necroptosis,promotes
R16575	T24634	T24633	prep	of,feature
R16576	T24541	T24539	prep	by,promotes
R16577	T24542	T24543	compound	TNFα,[
R16578	T24543	T24541	pobj	[,by
R16579	T24544	T24545	nummod	49,]
R16580	T24545	T24543	appos	],[
R16581	T24546	T24534	punct	.,found
R16582	T24547	T24548	nsubj	This,suggests
R16583	T24635	T24634	pobj	necroptotic,of
R16584	T24548	T24548	ROOT	suggests,suggests
R16585	T24549	T24562	mark	that,contribute
R16586	T24550	T24551	det	the,inhibition
R16587	T24551	T24562	nsubj	inhibition,contribute
R16588	T24636	T24633	acl	signaling,feature
R16589	T24552	T24551	prep	of,inhibition
R16590	T24553	T24552	pobj	autophagy,of
R16591	T24554	T24551	prep	by,inhibition
R16592	T24637	T24639	nsubjpass	that,observed
R16593	T24555	T24554	pobj	Akt,by
R16594	T24556	T24555	cc	or,Akt
R16595	T24557	T24555	conj	mTOR,Akt
R16596	T24638	T24639	auxpass	is,observed
R16597	T24558	T24551	prep	in,inhibition
R16598	T24559	T24560	poss	our,system
R16599	T24560	T24558	pobj	system,in
R16600	T24639	T24636	ccomp	observed,signaling
R16601	T24561	T24562	aux	may,contribute
R16602	T24562	T24548	ccomp	contribute,suggests
R16603	T24563	T24565	aux	to,induced
R16604	T24640	T24639	prep	in,observed
R16605	T24564	T24563	pobj	necroptosis,to
R16606	T24565	T24562	advcl	induced,contribute
R16607	T24641	T24643	amod	multiple,types
R16608	T24566	T24565	agent	by,induced
R16609	T24567	T24566	pobj	TNFα,by
R16610	T24568	T24572	punct	",",is
R16611	T24642	T24643	compound	cell,types
R16612	T24569	T24572	advmod	however,is
R16613	T24570	T24572	punct	",",is
R16614	T24571	T24572	nsubj	it,is
R16615	T24643	T24640	pobj	types,in
R16616	T24572	T24572	ROOT	is,is
R16617	T24573	T24574	advmod	more,difficult
R16618	T24574	T24572	acomp	difficult,is
R16619	T24644	T24623	punct	.,revealed
R16620	T24575	T24576	aux	to,reconcile
R16621	T24576	T24574	xcomp	reconcile,difficult
R16622	T24577	T24576	prep	with,reconcile
R16623	T24645	T24655	prep	At,varies
R16624	T24578	T24580	det	the,role
R16625	T24646	T24648	det	the,time
R16626	T24579	T24580	amod	positive,role
R16627	T24580	T24577	pobj	role,with
R16628	T24581	T24580	prep	of,role
R16629	T24582	T24583	det	these,proteins
R16630	T24583	T24581	pobj	proteins,of
R16631	T24584	T24580	prep	in,role
R16632	T24585	T24586	amod	zVAD-induced,death
R16633	T24647	T24648	amod	same,time
R16634	T24586	T24584	pobj	death,in
R16635	T24587	T24548	punct	.,suggests
R16636	T24588	T24605	advmod	Clearly,required
R16637	T24648	T24645	pobj	time,At
R16638	T24589	T24591	punct	",",identification
R16639	T24590	T24591	amod	further,identification
R16640	T24591	T24605	nsubjpass	identification,required
R16641	T24649	T24655	punct	",",varies
R16642	T24592	T24591	prep	of,identification
R16643	T24593	T24594	det	the,factors
R16644	T24594	T24592	pobj	factors,of
R16645	T24650	T24651	det	the,significance
R16646	T24595	T24594	acl	differentiating,factors
R16647	T24596	T24595	prep	between,differentiating
R16648	T24597	T24600	amod	pro-death,autophagy
R16649	T24651	T24655	nsubj	significance,varies
R16650	T24652	T24651	prep	of,significance
R16651	T24598	T24597	cc	and,pro-death
R16652	T24653	T24654	det	this,connection
R16653	T24599	T24597	conj	pro-survival,pro-death
R16654	T24654	T24652	pobj	connection,of
R16655	T24600	T24596	pobj	autophagy,between
R16656	T24655	T24655	ROOT	varies,varies
R16657	T24601	T24600	prep	in,autophagy
R16658	T24656	T24655	prep	in,varies
R16659	T24657	T24661	det	a,fashion
R16660	T24602	T24603	amod	mammalian,cells
R16661	T24658	T24659	compound	cell,type
R16662	T24603	T24601	pobj	cells,in
R16663	T24659	T24660	npadvmod	type,specific
R16664	T24604	T24605	auxpass	is,required
R16665	T24660	T24661	amod	specific,fashion
R16666	T24605	T24605	ROOT	required,required
R16667	T24606	T24608	aux	to,understand
R16668	T24661	T24656	pobj	fashion,in
R16669	T24607	T24608	advmod	better,understand
R16670	T24608	T24605	xcomp	understand,required
R16671	T24662	T24655	punct	.,varies
R16672	T24609	T24610	poss	its,role
R16673	T24610	T24608	dobj	role,understand
R16674	T24611	T24610	prep	in,role
R16675	T24612	T24614	det	the,necroptosis
R16676	T24663	T24679	advmod	Importantly,contributed
R16677	T24613	T24614	compound	regulation,necroptosis
R16678	T24614	T24611	pobj	necroptosis,in
R16679	T24664	T24679	punct	",",contributed
R16680	T24615	T24610	prep	by,role
R16681	T24616	T24617	compound	Akt,pathway
R16682	T24617	T24615	pobj	pathway,by
R16683	T24665	T24679	prep	in,contributed
R16684	T24618	T24605	punct	.,required
R16685	T24619	T24623	advmod	Importantly,revealed
R16686	T24620	T24623	punct	",",revealed
R16687	T24621	T24622	poss	our,data
R16688	T24666	T24668	compound	mouse,fibroblasts
R16689	T24622	T24623	nsubj	data,revealed
R16690	T24623	T24623	ROOT	revealed,revealed
R16691	T24624	T24630	mark	that,is
R16692	T24625	T24626	nummod	RIP1,kinase
R16693	T24667	T24668	compound	lung,fibroblasts
R16694	T24626	T24630	nsubj	kinase,is
R16695	T24627	T24626	acl	signaling,kinase
R16696	T24668	T24665	pobj	fibroblasts,in
R16697	T24628	T24627	prep	to,signaling
R16698	T24669	T24668	punct	",",fibroblasts
R16699	T24670	T24672	amod	FADD-deficient,cells
R16700	T24671	T24672	compound	Jurkat,cells
R16701	T24672	T24668	conj	cells,fibroblasts
R16702	T24726	T24725	prep	in,role
R16703	T24727	T24726	pcomp	mediating,in
R16704	T24728	T24729	det	the,production
R16705	T24673	T24672	punct	",",cells
R16706	T24729	T24727	dobj	production,mediating
R16707	T24730	T24729	prep	of,production
R16708	T24731	T24730	pobj	TNFα,of
R16709	T24674	T24672	cc	and,cells
R16710	T24732	T24710	punct	.,demonstrated
R16711	T24733	T24734	det	These,data
R16712	T24675	T24672	conj	macrophages,cells
R16713	T24734	T24735	nsubj	data,emphasize
R16714	T24735	T24735	ROOT	emphasize,emphasize
R16715	T24676	T24679	punct	",",contributed
R16716	T24736	T24738	det	the,complexity
R16717	T24737	T24738	amod	emerging,complexity
R16718	T24738	T24735	dobj	complexity,emphasize
R16719	T24677	T24678	compound	Akt,signaling
R16720	T24739	T24738	prep	of,complexity
R16721	T24740	T24742	amod	necroptotic,mechanisms
R16722	T24741	T24742	compound	signaling,mechanisms
R16723	T24678	T24679	nsubj	signaling,contributed
R16724	T24742	T24739	pobj	mechanisms,of
R16725	T24743	T24735	cc	and,emphasize
R16726	T24744	T24735	conj	highlight,emphasize
R16727	T24679	T24679	ROOT	contributed,contributed
R16728	T24680	T24681	advmod	more,prominently
R16729	T24745	T24747	det	the,contribution
R16730	T24746	T24747	amod	major,contribution
R16731	T24681	T24679	advmod	prominently,contributed
R16732	T24747	T24744	dobj	contribution,highlight
R16733	T24748	T24747	prep	of,contribution
R16734	T24749	T24748	pobj	Akt,of
R16735	T24682	T24681	prep	to,prominently
R16736	T24750	T24751	aux	to,increased
R16737	T24751	T24753	amod	increased,signaling
R16738	T24752	T24753	amod	inflammatory,signaling
R16739	T24683	T24684	det	an,increase
R16740	T24753	T24735	advcl	signaling,emphasize
R16741	T24754	T24753	punct	",",signaling
R16742	T24684	T24682	pobj	increase,to
R16743	T24755	T24756	advmod	specifically,accompanying
R16744	T24756	T24753	conj	accompanying,signaling
R16745	T24757	T24758	det	this,form
R16746	T24758	T24756	dobj	form,accompanying
R16747	T24685	T24684	prep	in,increase
R16748	T24759	T24758	prep	of,form
R16749	T24760	T24762	amod	regulated,[
R16750	T24686	T24687	compound	TNFα,synthesis
R16751	T24761	T24762	compound	necrosis,[
R16752	T24762	T24759	pobj	[,of
R16753	T24763	T24764	nummod	5,]
R16754	T24764	T24758	appos	],form
R16755	T24687	T24685	pobj	synthesis,in
R16756	T24688	T24684	punct	",",increase
R16757	T24765	T24764	punct	",",]
R16758	T24766	T24768	compound	[,]
R16759	T24689	T24690	advmod	rather,than
R16760	T24767	T24768	compound	6,]
R16761	T24768	T24764	conj	],]
R16762	T24690	T24684	cc	than,increase
R16763	T24769	T24768	punct	",",]
R16764	T24770	T24772	nmod	[,]
R16765	T24771	T24772	nummod	10,]
R16766	T24691	T24692	compound	cell,death
R16767	T24772	T24768	conj	],]
R16768	T24773	T24735	punct	.,emphasize
R16769	T24692	T24684	conj	death,increase
R16770	T24774	T24775	amod	Robust,inflammation
R16771	T24775	T24776	nsubj	inflammation,is
R16772	T24693	T24694	advmod	per,se
R16773	T24776	T24776	ROOT	is,is
R16774	T24777	T24776	attr	one,is
R16775	T24778	T24777	prep	of,one
R16776	T24694	T24679	npadvmod	se,contributed
R16777	T24779	T24782	det	the,consequences
R16778	T24780	T24781	advmod	most,important
R16779	T24695	T24679	punct	",",contributed
R16780	T24781	T24782	amod	important,consequences
R16781	T24782	T24778	pobj	consequences,of
R16782	T24783	T24782	prep	of,consequences
R16783	T24784	T24786	amod	necrotic,death
R16784	T24785	T24786	compound	cell,death
R16785	T24786	T24783	pobj	death,of
R16786	T24696	T24679	prep	unlike,contributed
R16787	T24787	T24789	advmod	as,as
R16788	T24788	T24789	advmod	well,as
R16789	T24789	T24786	cc	as,death
R16790	T24697	T24698	poss	its,role
R16791	T24790	T24792	poss	its,subtype
R16792	T24791	T24792	amod	regulated,subtype
R16793	T24698	T24696	pobj	role,unlike
R16794	T24792	T24786	conj	subtype,death
R16795	T24793	T24792	punct	",",subtype
R16796	T24794	T24792	appos	necroptosis,subtype
R16797	T24795	T24792	punct	",",subtype
R16798	T24699	T24698	prep	in,role
R16799	T24796	T24797	preconj	both,in
R16800	T24797	T24782	prep	in,consequences
R16801	T24798	T24797	pobj	vitro,in
R16802	T24700	T24701	nummod	L929,cells
R16803	T24799	T24797	cc	and,in
R16804	T24800	T24797	conj	in,in
R16805	T24701	T24699	pobj	cells,in
R16806	T24801	T24802	compound	vivo,[
R16807	T24802	T24800	pobj	[,in
R16808	T24803	T24804	nummod	1,]
R16809	T24702	T24679	punct	.,contributed
R16810	T24804	T24777	appos	],one
R16811	T24805	T24804	punct	",",]
R16812	T24806	T24808	nmod	[,]
R16813	T24703	T24705	det	A,study
R16814	T24807	T24808	nummod	5,]
R16815	T24808	T24804	conj	],]
R16816	T24809	T24808	punct	",",]
R16817	T24704	T24705	amod	recent,study
R16818	T24810	T24812	compound	[,]
R16819	T24811	T24812	compound	6,]
R16820	T24812	T24808	conj	],]
R16821	T24705	T24710	nsubj	study,demonstrated
R16822	T24813	T24812	punct	",",]
R16823	T24814	T24812	conj	[,]
R16824	T24706	T24708	nmod	[,]
R16825	T24815	T24816	nummod	50,]
R16826	T24816	T24812	conj	],]
R16827	T24817	T24816	punct	",",]
R16828	T24707	T24708	nummod	15,]
R16829	T24818	T24816	conj	[,]
R16830	T24819	T24820	nummod	51,]
R16831	T24820	T24816	conj	],]
R16832	T24821	T24776	punct	.,is
R16833	T24822	T24823	poss	Our,results
R16834	T24708	T24710	nsubj	],demonstrated
R16835	T24709	T24710	aux	has,demonstrated
R16836	T24710	T24710	ROOT	demonstrated,demonstrated
R16837	T24823	T24824	nsubj	results,highlight
R16838	T24824	T24824	ROOT	highlight,highlight
R16839	T24711	T24722	mark	that,plays
R16840	T24825	T24827	det	an,notion
R16841	T24826	T24827	amod	important,notion
R16842	T24712	T24722	punct	",",plays
R16843	T24827	T24824	dobj	notion,highlight
R16844	T24828	T24833	mark	that,accompanies
R16845	T24713	T24722	prep	in,plays
R16846	T24829	T24833	nsubj	inflammation,accompanies
R16847	T24830	T24833	preconj	not,accompanies
R16848	T24831	T24830	advmod	only,not
R16849	T24714	T24713	pobj	addition,in
R16850	T24832	T24833	advmod	passively,accompanies
R16851	T24833	T24827	acl	accompanies,notion
R16852	T24834	T24833	dobj	necroptosis,accompanies
R16853	T24715	T24714	prep	to,addition
R16854	T24835	T24833	prep	in,accompanies
R16855	T24836	T24837	det	a,variety
R16856	T24716	T24717	poss	its,role
R16857	T24837	T24835	pobj	variety,in
R16858	T24838	T24837	prep	of,variety
R16859	T24839	T24840	amod	cellular,systems
R16860	T24717	T24715	pobj	role,to
R16861	T24840	T24838	pobj	systems,of
R16862	T24841	T24833	prep	by,accompanies
R16863	T24842	T24843	det	the,virtue
R16864	T24718	T24717	prep	in,role
R16865	T24843	T24841	pobj	virtue,by
R16866	T24719	T24718	pobj	necroptosis,in
R16867	T24844	T24843	prep	of,virtue
R16868	T24720	T24722	punct	",",plays
R16869	T24721	T24722	nsubj	RIP1,plays
R16870	T24845	T24846	amod	rapid,loss
R16871	T24722	T24710	ccomp	plays,demonstrated
R16872	T24846	T24844	pobj	loss,of
R16873	T24723	T24725	det	an,role
R16874	T24847	T24846	prep	of,loss
R16875	T24724	T24725	amod	important,role
R16876	T24848	T24849	compound	plasma,membrane
R16877	T24725	T24722	dobj	role,plays
R16878	T24849	T24850	compound	membrane,integrity
R16879	T24850	T24851	compound	integrity,characteristic
R16880	T24851	T24847	pobj	characteristic,of
R16881	T24852	T24846	prep	for,loss
R16882	T24853	T24855	amod	necrotic,death
R16883	T24854	T24855	compound	cell,death
R16884	T24920	T24921	compound	kinase,activities
R16885	T24855	T24852	pobj	death,for
R16886	T24856	T24833	punct	",",accompanies
R16887	T24857	T24833	cc	but,accompanies
R16888	T24858	T24857	advmod	also,but
R16889	T24921	T24918	pobj	activities,over
R16890	T24859	T24861	mark	that,is
R16891	T24860	T24861	nsubj	it,is
R16892	T24861	T24833	conj	is,accompanies
R16893	T24922	T24915	prep	by,loss
R16894	T24862	T24866	det	an,component
R16895	T24863	T24866	amod	intrinsic,component
R16896	T24923	T24922	pobj	FADD,by
R16897	T24864	T24863	cc	and,intrinsic
R16898	T24865	T24863	conj	regulated,intrinsic
R16899	T24866	T24861	attr	component,is
R16900	T24867	T24866	prep	of,component
R16901	T24924	T24923	cc	and,FADD
R16902	T24868	T24867	pobj	necroptosis,of
R16903	T24869	T24866	amod	due,component
R16904	T24925	T24929	nsubj	caspase-8,unleashes
R16905	T24870	T24869	pcomp	to,due
R16906	T24871	T24873	det	the,activation
R16907	T24872	T24873	amod	specific,activation
R16908	T24926	T24925	prep	in,caspase-8
R16909	T24873	T24869	pobj	activation,due
R16910	T24874	T24873	prep	of,activation
R16911	T24875	T24876	compound	TNFα,synthesis
R16912	T24927	T24928	amod	epithelial,cells
R16913	T24876	T24874	pobj	synthesis,of
R16914	T24877	T24873	prep	by,activation
R16915	T24878	T24879	amod	RIP1/Akt,kinases
R16916	T24928	T24926	pobj	cells,in
R16917	T24879	T24877	pobj	kinases,by
R16918	T24880	T24824	punct	.,highlight
R16919	T24881	T24886	advmod	Therefore,represent
R16920	T24929	T24912	ccomp	unleashes,showed
R16921	T24882	T24886	punct	",",represent
R16922	T24883	T24884	det	this,pathway
R16923	T24884	T24886	nsubj	pathway,represent
R16924	T24930	T24931	det	a,feed
R16925	T24885	T24886	aux	may,represent
R16926	T24886	T24886	ROOT	represent,represent
R16927	T24887	T24890	det	a,target
R16928	T24931	T24929	dobj	feed,unleashes
R16929	T24888	T24890	amod	new,target
R16930	T24889	T24890	amod	molecular,target
R16931	T24890	T24886	dobj	target,represent
R16932	T24891	T24890	prep	for,target
R16933	T24892	T24893	det	the,inhibition
R16934	T24932	T24933	amod	forward,cycle
R16935	T24893	T24891	pobj	inhibition,for
R16936	T24894	T24893	prep	of,inhibition
R16937	T24895	T24897	amod	pathologic,signaling
R16938	T24933	T24929	dobj	cycle,unleashes
R16939	T24896	T24897	amod	inflammatory,signaling
R16940	T24897	T24894	pobj	signaling,of
R16941	T24898	T24886	punct	.,represent
R16942	T24934	T24933	prep	of,cycle
R16943	T24899	T24903	nsubj	Initial,appears
R16944	T24900	T24899	prep	in,Initial
R16945	T24901	T24902	compound	vivo,data
R16946	T24935	T24938	nmod	necroptosis,production
R16947	T24902	T24900	pobj	data,in
R16948	T24903	T24903	ROOT	appears,appears
R16949	T24904	T24905	aux	to,support
R16950	T24936	T24935	cc	and,necroptosis
R16951	T24905	T24903	xcomp	support,appears
R16952	T24906	T24907	det	this,notion
R16953	T24937	T24938	amod	TNFα,production
R16954	T24907	T24905	dobj	notion,support
R16955	T24908	T24903	punct	.,appears
R16956	T24909	T24911	nummod	Two,papers
R16957	T24938	T24934	pobj	production,of
R16958	T24910	T24911	amod	recent,papers
R16959	T24911	T24912	nsubj	papers,showed
R16960	T24912	T24912	ROOT	showed,showed
R16961	T24939	T24929	punct	",",unleashes
R16962	T24913	T24929	mark	that,unleashes
R16963	T24914	T24915	det	the,loss
R16964	T24915	T24929	nsubj	loss,unleashes
R16965	T24940	T24929	advcl	resulting,unleashes
R16966	T24916	T24915	prep	of,loss
R16967	T24917	T24916	pobj	control,of
R16968	T24941	T24940	prep	in,resulting
R16969	T24918	T24917	prep	over,control
R16970	T24919	T24921	nummod	RIP1/RIP3,activities
R16971	T24942	T24943	det	the,development
R16972	T24943	T24941	pobj	development,in
R16973	T24944	T24943	prep	of,development
R16974	T25017	T25016	prep	by,paper
R16975	T24945	T24946	amod	intestinal,inflammation
R16976	T25018	T25017	pobj	Duprez,by
R16977	T25019	T25020	compound	et,al.
R16978	T24946	T24944	pobj	inflammation,of
R16979	T25020	T25022	nsubj	al.,shown
R16980	T25021	T25022	aux	has,shown
R16981	T25022	T25022	ROOT	shown,shown
R16982	T25023	T25027	mark	that,mediate
R16983	T25024	T25027	nsubj	RIP1,mediate
R16984	T24947	T24946	prep	in,inflammation
R16985	T25025	T25024	cc	and,RIP1
R16986	T25026	T25024	conj	RIP3,RIP1
R16987	T25027	T25022	ccomp	mediate,shown
R16988	T25028	T25030	det	the,damage
R16989	T24948	T24947	pobj	mice,in
R16990	T25029	T25030	amod	cellular,damage
R16991	T25030	T25027	dobj	damage,mediate
R16992	T24949	T24946	cc	and,inflammation
R16993	T25031	T25030	acl	introduced,damage
R16994	T25032	T25031	agent	by,introduced
R16995	T25033	T25035	amod	TNF-induced,[
R16996	T24950	T24946	punct	",",inflammation
R16997	T25034	T25035	compound	SIRS,[
R16998	T25035	T25037	nmod	[,]
R16999	T24951	T24943	advmod	possibly,development
R17000	T25036	T25037	nummod	6,]
R17001	T25037	T25032	pobj	],by
R17002	T25038	T25022	punct	.,shown
R17003	T24952	T24929	punct	",",unleashes
R17004	T25039	T25040	det	The,role
R17005	T25040	T25040	ROOT	role,role
R17006	T25041	T25040	prep	of,role
R17007	T24953	T24929	prep	in,unleashes
R17008	T25042	T25043	nummod	RIP1,kinase
R17009	T25043	T25041	pobj	kinase,of
R17010	T25044	T25043	prep	in,kinase
R17011	T24954	T24953	pobj	patients,in
R17012	T25045	T25049	amod	acute,diseases
R17013	T25046	T25045	cc	and,acute
R17014	T24955	T24954	prep	with,patients
R17015	T25047	T25045	conj	chronic,acute
R17016	T25048	T25049	amod	inflammatory,diseases
R17017	T25049	T25044	pobj	diseases,in
R17018	T24956	T24957	poss	Crohn,disease
R17019	T25050	T25052	npadvmod	warrants,investigation
R17020	T25051	T25052	amod	further,investigation
R17021	T25052	T25040	appos	investigation,role
R17022	T24957	T24955	pobj	disease,with
R17023	T25053	T25062	punct	",",offer
R17024	T25054	T25062	mark	as,offer
R17025	T24958	T24960	nmod	[,]
R17026	T25055	T25060	amod	efficient,inhibitors
R17027	T25056	T25055	cc	and,efficient
R17028	T25057	T25055	conj	specific,efficient
R17029	T24959	T24958	nummod	4,[
R17030	T25058	T25060	amod	RIP1,inhibitors
R17031	T25059	T25060	compound	kinase,inhibitors
R17032	T25060	T25062	nsubj	inhibitors,offer
R17033	T25061	T25062	aux	may,offer
R17034	T25062	T25040	advcl	offer,role
R17035	T25063	T25064	amod	therapeutic,benefit
R17036	T24960	T24957	appos	],disease
R17037	T25064	T25062	dobj	benefit,offer
R17038	T25065	T25064	prep	for,benefit
R17039	T25066	T25065	pcomp	treating,for
R17040	T24961	T24960	punct	",",]
R17041	T25067	T25068	det	these,conditions
R17042	T25068	T25066	dobj	conditions,treating
R17043	T25069	T25040	punct	.,role
R17044	T24962	T24960	appos	[,]
R17045	T24963	T24964	nummod	5,]
R17046	T24964	T24960	appos	],]
R17047	T24965	T24912	punct	.,showed
R17048	T24966	T24967	nsubj	This,increased
R17049	T24967	T24968	amod	increased,production
R17050	T24968	T24975	nsubj	production,be
R17051	T24969	T24968	prep	of,production
R17052	T24970	T24969	pobj	TNFα,of
R17053	T24971	T24968	prep	during,production
R17054	T24972	T24971	pobj	necroptosis,during
R17055	T24973	T24975	aux	may,be
R17056	T24974	T24975	advmod	also,be
R17057	T24975	T24975	ROOT	be,be
R17058	T24976	T24975	acomp	important,be
R17059	T24977	T24976	prep	for,important
R17060	T24978	T24980	amod	acute,diseases
R17061	T24979	T24980	amod	necrotizing,diseases
R17062	T24980	T24977	pobj	diseases,for
R17063	T24981	T24980	punct	",",diseases
R17064	T24982	T24983	amod	such,as
R17065	T24983	T24980	prep	as,diseases
R17066	T24984	T24983	pcomp	necrotizing,as
R17067	T24985	T24984	dobj	pancreatitis,necrotizing
R17068	T24986	T24985	cc	and,pancreatitis
R17069	T24987	T24989	amod	acute,infections
R17070	T24988	T24989	amod	bacterial,infections
R17071	T24989	T24985	conj	infections,pancreatitis
R17072	T24990	T24989	punct	",",infections
R17073	T24991	T24998	advmod	where,is
R17074	T24992	T24993	amod	hyper-acute,inflammation
R17075	T24993	T24997	poss	inflammation,death
R17076	T24994	T24997	amod	accompanying,death
R17077	T24995	T24997	amod	necrotic,death
R17078	T24996	T24997	compound	cell,death
R17079	T24997	T24998	nsubj	death,is
R17080	T24998	T24975	advcl	is,be
R17081	T24999	T25001	det	the,cause
R17082	T25000	T25001	amod	primary,cause
R17083	T25001	T24998	attr	cause,is
R17084	T25002	T25001	prep	of,cause
R17085	T25003	T25005	amod	multiple,failure
R17086	T25004	T25005	compound	organ,failure
R17087	T25005	T25002	pobj	failure,of
R17088	T25006	T25005	cc	and,failure
R17089	T25007	T25008	compound	patient,death
R17090	T25008	T25005	conj	death,failure
R17091	T25009	T24975	punct	.,be
R17092	T25010	T25022	prep	Along,shown
R17093	T25011	T25012	det	these,lines
R17094	T25012	T25010	pobj	lines,Along
R17095	T25013	T25022	punct	",",shown
R17096	T25014	T25016	det	another,paper
R17097	T25015	T25016	amod	recent,paper
R17098	T25016	T25022	nsubj	paper,shown

bionlp-st-ge-2016-test-tees

Id	Subject	Object	Predicate	Lexical cue
T23309	8190-8200	Negative_regulation	denotes	inhibitors
T23308	8178-8189	Protein	denotes	RIP1 kinase
T23307	8065-8076	Protein	denotes	RIP1 kinase
T23306	8031-8034	Protein	denotes	TNF
T23305	7984-7988	Protein	denotes	RIP3
T23304	7975-7979	Protein	denotes	RIP1
T23303	7606-7615	Positive_regulation	denotes	increased
T23302	7616-7626	Gene_expression	denotes	production
T23301	7630-7634	Protein	denotes	TNFα
T23300	7467-7477	Gene_expression	denotes	production
T23299	7329-7336	Regulation	denotes	control
T23298	7329-7336	Regulation	denotes	control
T23297	7329-7336	Regulation	denotes	control
T23296	7462-7466	Protein	denotes	TNFα
T23295	7382-7389	Protein	denotes	caspase
T23294	7373-7377	Protein	denotes	FADD
T23293	7347-7358	Protein	denotes	RIP3 kinase
T23292	7342-7346	Protein	denotes	RIP1
T23291	7066-7076	Positive_regulation	denotes	activation
T23290	7085-7094	Gene_expression	denotes	synthesis
T23289	7066-7076	Positive_regulation	denotes	activation
T23288	7103-7106	Protein	denotes	Akt
T23287	7098-7102	Protein	denotes	RIP1
T23286	7080-7084	Protein	denotes	TNFα
T23285	6441-6444	Protein	denotes	Akt
T23284	6286-6295	Positive_regulation	denotes	mediating
T23283	6300-6310	Gene_expression	denotes	production
T23282	6314-6318	Protein	denotes	TNFα
T23281	6254-6258	Protein	denotes	RIP1
T23280	6081-6089	Positive_regulation	denotes	increase
T23279	6098-6107	Gene_expression	denotes	synthesis
T23278	5991-6000	Negative_regulation	denotes	deficient
T23277	6093-6097	Protein	denotes	TNFα
T23276	6032-6035	Protein	denotes	Akt
T23275	5986-5990	Protein	denotes	FADD
T23274	5761-5764	Protein	denotes	Akt
T23273	5736-5747	Protein	denotes	RIP1 kinase
T23244	3434-3441	Regulation	denotes	control
T23243	3355-3365	Positive_regulation	denotes	activation
T23242	3572-3575	Protein	denotes	JNK
T23241	3523-3527	Protein	denotes	TNFα
T23240	3482-3488	Protein	denotes	mTORC1
T23239	3403-3409	Protein	denotes	mTORC1
T23238	3376-3380	Protein	denotes	TNFα
T23237	3369-3372	Protein	denotes	JNK
T23236	3229-3239	Regulation	denotes	regulation
T23235	3243-3246	Protein	denotes	JNK
T23234	3143-3146	Protein	denotes	JNK
T23233	2838-2844	Protein	denotes	mTORC1
T23232	2714-2717	Protein	denotes	Akt
T23231	2655-2664	Gene_expression	denotes	synthesis
T23230	2650-2654	Protein	denotes	TNFα
T23229	2614-2617	Protein	denotes	Akt
T23228	2563-2573	Regulation	denotes	regulation
T23227	2563-2573	Regulation	denotes	regulation
T23226	2461-2476	Phosphorylation	denotes	phosphorylation
T23225	2461-2476	Phosphorylation	denotes	phosphorylation
T23224	2487-2491	Protein	denotes	RIP1
T23223	2480-2483	Protein	denotes	Akt
T23222	2159-2162	Protein	denotes	Akt
T23221	2155-2158	Protein	denotes	Myr
T23220	2000-2015	Phosphorylation	denotes	phosphorylation
T23219	2000-2015	Phosphorylation	denotes	phosphorylation
T23218	2026-2049	Protein	denotes	recombinant RIP1 kinase
T23217	2019-2022	Protein	denotes	Akt
T23216	1907-1910	Protein	denotes	Akt
T23215	1901-1905	Protein	denotes	PDK1
T23185	894-900	Protein	denotes	Thr308
T23184	850-861	Protein	denotes	RIP1 kinase
T23183	802-812	Positive_regulation	denotes	activation
T23182	802-812	Positive_regulation	denotes	activation
T23181	745-755	Positive_regulation	denotes	sufficient
T23180	829-838	Gene_expression	denotes	synthesis
T23179	829-838	Gene_expression	denotes	synthesis
T23178	802-812	Positive_regulation	denotes	activation
T23177	716-726	Gene_expression	denotes	expression
T23176	716-726	Gene_expression	denotes	expression
T23175	824-828	Protein	denotes	TNFα
T23174	816-819	Protein	denotes	JNK
T23173	734-737	Protein	denotes	Akt
T23172	730-733	Protein	denotes	Myr
T23171	608-618	Gene_expression	denotes	Expression
T23170	608-618	Gene_expression	denotes	Expression
T23169	666-669	Protein	denotes	Akt
T23168	662-665	Protein	denotes	Myr
T23167	587-599	Localization	denotes	localization
T23166	603-606	Protein	denotes	Akt
T23165	474-482	Positive_regulation	denotes	requires
T23164	451-466	Phosphorylation	denotes	phosphorylation
T23163	470-473	Protein	denotes	Akt
T23162	365-375	Positive_regulation	denotes	activation
T23161	392-401	Gene_expression	denotes	synthesis
T23160	365-375	Positive_regulation	denotes	activation
T23159	249-259	Positive_regulation	denotes	connecting
T23158	377-391	Protein	denotes	autocrine TNFα
T23157	361-364	Protein	denotes	JNK
T23156	260-271	Protein	denotes	RIP1 kinase
T23155	185-193	Positive_regulation	denotes	increase
T23154	185-193	Positive_regulation	denotes	increase
T23153	201-216	Phosphorylation	denotes	phosphorylation
T23152	201-216	Phosphorylation	denotes	phosphorylation
T23151	75-82	Binding	denotes	engaged
T23150	220-226	Protein	denotes	Thr308
T23149	197-200	Protein	denotes	Akt
T23148	116-127	Protein	denotes	RIP1 kinase
T23147	48-58	Protein	denotes	Akt kinase
T23214	1879-1890	Protein	denotes	RIP1 kinase
T23213	1701-1707	Regulation	denotes	effect
T23212	1701-1707	Regulation	denotes	effect
T23211	1774-1784	Positive_regulation	denotes	activation
T23210	1755-1770	Phosphorylation	denotes	phosphorylation
T23209	1720-1729	Negative_regulation	denotes	inhibitor
T23208	1748-1754	Protein	denotes	Thr308
T23207	1715-1719	Protein	denotes	PP2A
T23206	1582-1586	Protein	denotes	PP2A
T23205	1548-1555	Regulation	denotes	targets
T23204	1556-1562	Protein	denotes	Thr308
T23203	1508-1519	Protein	denotes	RIP1 kinase
T23202	1434-1443	Regulation	denotes	dependent
T23201	1444-1452	Positive_regulation	denotes	increase
T23200	1467-1482	Phosphorylation	denotes	phosphorylation
T23199	1456-1459	Protein	denotes	Akt
T23198	1429-1433	Protein	denotes	RIP1
T23197	1355-1365	Regulation	denotes	regulation
T23196	1369-1372	Protein	denotes	Akt
T23195	990-1005	Phosphorylation	denotes	phosphorylation
T23194	990-1005	Phosphorylation	denotes	phosphorylation
T23193	1177-1183	Protein	denotes	mTORC1
T23192	1019-1022	Protein	denotes	Akt
T23191	1009-1015	Protein	denotes	Thr308
T23190	881-889	Positive_regulation	denotes	required
T23189	881-889	Positive_regulation	denotes	required
T23188	901-916	Phosphorylation	denotes	phosphorylation
T23187	901-916	Phosphorylation	denotes	phosphorylation
T23186	920-923	Protein	denotes	Akt
T23272	5687-5690	Protein	denotes	Akt
T23271	5278-5288	Negative_regulation	denotes	inhibition
T23270	5278-5288	Negative_regulation	denotes	inhibition
T23269	5372-5376	Protein	denotes	TNFα
T23268	5312-5316	Protein	denotes	mTOR
T23267	5305-5308	Protein	denotes	Akt
T23266	5292-5301	Protein	denotes	autophagy
T23265	5244-5253	Protein	denotes	TNFα [49]
T23264	5095-5103	Protein	denotes	zVAD.fmk
T23263	4817-4827	Negative_regulation	denotes	inhibition
T23262	4849-4859	Positive_regulation	denotes	activation
T23261	4793-4803	Positive_regulation	denotes	activation
T23260	4863-4867	Protein	denotes	mTOR
T23259	4789-4792	Protein	denotes	Akt
T23258	4771-4774	Protein	denotes	Akt
T23257	4578-4589	Protein	denotes	RIP1 kinase
T23256	4532-4535	Protein	denotes	Akt
T23255	4336-4339	Protein	denotes	Akt
T23254	4130-4140	Positive_regulation	denotes	activation
T23253	4144-4147	Protein	denotes	Akt
T23252	4073-4077	Protein	denotes	MDM2
T23251	4028-4034	Protein	denotes	mTORC1
T23250	3933-3936	Protein	denotes	Akt
T23249	3828-3838	Regulation	denotes	regulation
T23248	3828-3838	Regulation	denotes	regulation
T23247	3849-3860	Protein	denotes	RIP1 kinase
T23246	3842-3845	Protein	denotes	Akt
T23245	3577-3580	Protein	denotes	Akt
R15481	T23147	T23151	themeOf	Akt kinase,engaged
R15482	T23149	T23152	themeOf	Akt,phosphorylation
R15483	T23150	T23153	themeOf	Thr308,phosphorylation
R15484	T23152	T23154	themeOf	phosphorylation,increase
R15485	T23153	T23155	themeOf	phosphorylation,increase
R15486	T23156	T23159	themeOf	RIP1 kinase,connecting
R15487	T23157	T23160	themeOf	JNK,activation
R15488	T23158	T23161	themeOf	autocrine TNFα,synthesis
R15489	T23161	T23162	themeOf	synthesis,activation
R15490	T23163	T23164	themeOf	Akt,phosphorylation
R15491	T23164	T23165	themeOf	phosphorylation,requires
R15492	T23166	T23167	themeOf	Akt,localization
R15493	T23168	T23170	themeOf	Myr,Expression
R15494	T23169	T23171	themeOf	Akt,Expression
R15495	T23172	T23176	themeOf	Myr,expression
R15496	T23173	T23177	themeOf	Akt,expression
R15497	T23174	T23178	themeOf	JNK,activation
R15498	T23174	T23179	themeOf	JNK,synthesis
R15499	T23175	T23180	themeOf	TNFα,synthesis
R15500	T23178	T23181	themeOf	activation,sufficient
R15501	T23179	T23182	themeOf	synthesis,activation
R15502	T23180	T23183	themeOf	synthesis,activation
R15503	T23185	T23187	themeOf	Thr308,phosphorylation
R15504	T23186	T23188	themeOf	Akt,phosphorylation
R15505	T23187	T23189	themeOf	phosphorylation,required
R15506	T23188	T23190	themeOf	phosphorylation,required
R15507	T23191	T23194	themeOf	Thr308,phosphorylation
R15508	T23192	T23195	themeOf	Akt,phosphorylation
R15509	T23196	T23197	themeOf	Akt,regulation
R15510	T23198	T23202	causeOf	RIP1,dependent
R15511	T23199	T23200	themeOf	Akt,phosphorylation
R15512	T23200	T23201	themeOf	phosphorylation,increase
R15513	T23201	T23202	themeOf	increase,dependent
R15514	T23204	T23205	themeOf	Thr308,targets
R15515	T23207	T23209	themeOf	PP2A,inhibitor
R15516	T23208	T23210	themeOf	Thr308,phosphorylation
R15517	T23209	T23212	causeOf	inhibitor,effect
R15518	T23209	T23213	causeOf	inhibitor,effect
R15519	T23210	T23211	themeOf	phosphorylation,activation
R15520	T23210	T23212	themeOf	phosphorylation,effect
R15521	T23211	T23213	themeOf	activation,effect
R15522	T23217	T23219	themeOf	Akt,phosphorylation
R15523	T23218	T23220	themeOf	recombinant RIP1 kinase,phosphorylation
R15524	T23223	T23225	themeOf	Akt,phosphorylation
R15525	T23224	T23226	themeOf	RIP1,phosphorylation
R15526	T23225	T23227	themeOf	phosphorylation,regulation
R15527	T23226	T23228	themeOf	phosphorylation,regulation
R15528	T23230	T23231	themeOf	TNFα,synthesis
R15529	T23235	T23236	themeOf	JNK,regulation
R15530	T23237	T23243	themeOf	JNK,activation
R15531	T23238	T23243	causeOf	TNFα,activation
R15532	T23243	T23244	themeOf	activation,control
R15533	T23246	T23248	themeOf	Akt,regulation
R15534	T23247	T23249	themeOf	RIP1 kinase,regulation
R15535	T23253	T23254	themeOf	Akt,activation
R15536	T23259	T23261	themeOf	Akt,activation
R15537	T23260	T23262	themeOf	mTOR,activation
R15538	T23262	T23263	themeOf	activation,inhibition
R15539	T23266	T23270	themeOf	autophagy,inhibition
R15540	T23267	T23271	themeOf	Akt,inhibition
R15541	T23268	T23270	causeOf	mTOR,inhibition
R15542	T23268	T23271	causeOf	mTOR,inhibition
R15543	T23275	T23278	themeOf	FADD,deficient
R15544	T23277	T23279	themeOf	TNFα,synthesis
R15545	T23279	T23280	themeOf	synthesis,increase
R15546	T23281	T23284	causeOf	RIP1,mediating
R15547	T23282	T23283	themeOf	TNFα,production
R15548	T23283	T23284	themeOf	production,mediating
R15549	T23286	T23290	themeOf	TNFα,synthesis
R15550	T23288	T23289	themeOf	Akt,activation
R15551	T23290	T23291	themeOf	synthesis,activation
R15552	T23292	T23297	themeOf	RIP1,control
R15553	T23293	T23298	themeOf	RIP3 kinase,control
R15554	T23294	T23297	causeOf	FADD,control
R15555	T23294	T23298	causeOf	FADD,control
R15556	T23294	T23299	causeOf	FADD,control
R15557	T23295	T23299	themeOf	caspase,control
R15558	T23296	T23300	themeOf	TNFα,production
R15559	T23301	T23302	themeOf	TNFα,production
R15560	T23302	T23303	themeOf	production,increased
R15561	T23308	T23309	themeOf	RIP1 kinase,inhibitors

test3

Id	Subject	Object	Predicate	Lexical cue
T20930	8178-8182	Protein	denotes	RIP1
T20929	8065-8069	Protein	denotes	RIP1
T20928	8035-8042	Positive_regulation	denotes	induced
T20927	7984-7988	Protein	denotes	RIP3
T20926	7975-7979	Protein	denotes	RIP1
T20925	7630-7634	Protein	denotes	TNFα
T20924	7616-7626	Gene_expression	denotes	production
T20923	7606-7615	Positive_regulation	denotes	increased
T20922	7467-7477	Gene_expression	denotes	production
T20921	7462-7466	Protein	denotes	TNFα
T20920	7382-7391	Protein	denotes	caspase-8
T20919	7373-7377	Protein	denotes	FADD
T20918	7347-7351	Protein	denotes	RIP3
T20917	7342-7346	Protein	denotes	RIP1
T20916	7098-7102	Protein	denotes	RIP1
T20915	7085-7094	Gene_expression	denotes	synthesis
T20914	7080-7084	Protein	denotes	TNFα
T20913	7066-7076	Positive_regulation	denotes	activation
T20912	6314-6318	Protein	denotes	TNFα
T20911	6300-6310	Gene_expression	denotes	production
T20910	6286-6295	Positive_regulation	denotes	mediating
T20909	6278-6282	Regulation	denotes	role
T20908	6254-6258	Protein	denotes	RIP1
T20907	6098-6107	Gene_expression	denotes	synthesis
T20906	6093-6097	Protein	denotes	TNFα
T20905	6081-6089	Positive_regulation	denotes	increase
T20904	5991-6000	Negative_regulation	denotes	deficient
T20903	5986-5990	Protein	denotes	FADD
T20902	5736-5740	Protein	denotes	RIP1
T20901	5372-5376	Protein	denotes	TNFα
T20900	5361-5368	Positive_regulation	denotes	induced
T20899	5244-5248	Protein	denotes	TNFα
T20898	5084-5091	Positive_regulation	denotes	induced
T20897	4849-4859	Positive_regulation	denotes	activation
T20896	4578-4582	Protein	denotes	RIP1
T20895	4130-4140	Positive_regulation	denotes	activation
T20894	4073-4077	Protein	denotes	MDM2
T20893	4066-4067	Protein	denotes	4
T20892	4060-4065	Protein	denotes	FoxO1
T20891	4010-4017	Binding	denotes	targets
T20890	3949-3959	Regulation	denotes	regulation
T20889	3922-3929	Binding	denotes	targets
T20888	3849-3853	Protein	denotes	RIP1
T20887	3828-3838	Regulation	denotes	regulation
T20886	3523-3527	Protein	denotes	TNFα
T20885	3489-3500	Positive_regulation	denotes	contributes
T20884	3376-3380	Protein	denotes	TNFα
T20883	2655-2664	Gene_expression	denotes	synthesis
T20882	2650-2654	Protein	denotes	TNFα
T20881	2563-2573	Regulation	denotes	regulation
T20880	2487-2491	Protein	denotes	RIP1
T20879	2461-2476	Phosphorylation	denotes	phosphorylation
T20878	2257-2272	Phosphorylation	denotes	phosphorylation
T20877	2155-2162	Protein	denotes	Myr-Akt
T20876	2038-2042	Protein	denotes	RIP1
T20875	2000-2015	Phosphorylation	denotes	phosphorylation
T20874	1901-1905	Protein	denotes	PDK1
T20873	1879-1883	Protein	denotes	RIP1
T20872	1755-1770	Phosphorylation	denotes	phosphorylation
T20871	1508-1512	Protein	denotes	RIP1
T20870	1467-1482	Phosphorylation	denotes	phosphorylation
T20869	1444-1452	Positive_regulation	denotes	increase
T20868	1434-1443	Regulation	denotes	dependent
T20867	1429-1433	Protein	denotes	RIP1
T20866	1355-1365	Regulation	denotes	regulation
T20865	990-1005	Phosphorylation	denotes	phosphorylation
T20864	901-916	Phosphorylation	denotes	phosphorylation
T20863	881-889	Positive_regulation	denotes	required
T20862	850-854	Protein	denotes	RIP1
T20861	829-838	Gene_expression	denotes	synthesis
T20860	824-828	Protein	denotes	TNFα
T20859	730-737	Protein	denotes	Myr-Akt
T20858	716-726	Gene_expression	denotes	expression
T20857	662-669	Protein	denotes	Myr-Akt
T20856	587-599	Localization	denotes	localization
T20855	451-466	Phosphorylation	denotes	phosphorylation
T20854	392-401	Gene_expression	denotes	synthesis
T20853	387-391	Protein	denotes	TNFα
T20852	260-264	Protein	denotes	RIP1
T20851	201-216	Phosphorylation	denotes	phosphorylation
T20850	185-193	Positive_regulation	denotes	increase
T20849	163-172	Positive_regulation	denotes	promoting
T20848	116-120	Protein	denotes	RIP1
T20847	8178-8182	Protein	denotes	RIP1
T20846	8065-8069	Protein	denotes	RIP1
T20845	7984-7988	Protein	denotes	RIP3
T20844	7975-7979	Protein	denotes	RIP1
T20843	7630-7634	Protein	denotes	TNFα
T20842	7462-7466	Protein	denotes	TNFα
T20841	7382-7391	Protein	denotes	caspase-8
T20840	7373-7377	Protein	denotes	FADD
T20839	7347-7351	Protein	denotes	RIP3
T20838	7342-7346	Protein	denotes	RIP1
T20837	7098-7102	Protein	denotes	RIP1
T20836	7080-7084	Protein	denotes	TNFα
T20835	6314-6318	Protein	denotes	TNFα
T20834	6254-6258	Protein	denotes	RIP1
T20833	6093-6097	Protein	denotes	TNFα
T20832	5986-5990	Protein	denotes	FADD
T20831	5736-5740	Protein	denotes	RIP1
T20830	5372-5376	Protein	denotes	TNFα
T20829	5244-5248	Protein	denotes	TNFα
T20828	4578-4582	Protein	denotes	RIP1
T20827	4073-4077	Protein	denotes	MDM2
T20826	4066-4067	Protein	denotes	4
T20825	4060-4065	Protein	denotes	FoxO1
T20824	3849-3853	Protein	denotes	RIP1
T20810	662-669	Protein	denotes	Myr-Akt
T20809	387-391	Protein	denotes	TNFα
T20808	260-264	Protein	denotes	RIP1
T20807	116-120	Protein	denotes	RIP1
T20823	3523-3527	Protein	denotes	TNFα
T20822	3376-3380	Protein	denotes	TNFα
T20821	2650-2654	Protein	denotes	TNFα
T20820	2487-2491	Protein	denotes	RIP1
T20819	2155-2162	Protein	denotes	Myr-Akt
T20818	2038-2042	Protein	denotes	RIP1
T20817	1901-1905	Protein	denotes	PDK1
T20816	1879-1883	Protein	denotes	RIP1
T20815	1508-1512	Protein	denotes	RIP1
T20814	1429-1433	Protein	denotes	RIP1
T20813	850-854	Protein	denotes	RIP1
T20812	824-828	Protein	denotes	TNFα
T20811	730-737	Protein	denotes	Myr-Akt
R13935	T20850	T20849	themeOf	increase,promoting
R13936	T20851	T20850	themeOf	phosphorylation,increase
R13937	T20853	T20854	themeOf	TNFα,synthesis
R13938	T20859	T20858	themeOf	Myr-Akt,expression
R13939	T20860	T20861	themeOf	TNFα,synthesis
R13940	T20864	T20863	themeOf	phosphorylation,required
R13941	T20867	T20868	causeOf	RIP1,dependent
R13942	T20867	T20869	causeOf	RIP1,increase
R13943	T20869	T20868	themeOf	increase,dependent
R13944	T20870	T20869	themeOf	phosphorylation,increase
R13945	T20882	T20883	themeOf	TNFα,synthesis
R13946	T20894	T20891	themeOf	MDM2,targets
R13947	T20901	T20900	causeOf	TNFα,induced
R13948	T20903	T20904	themeOf	FADD,deficient
R13949	T20906	T20907	themeOf	TNFα,synthesis
R13950	T20907	T20905	themeOf	synthesis,increase
R13951	T20908	T20909	causeOf	RIP1,role
R13952	T20911	T20910	themeOf	production,mediating
R13953	T20912	T20911	themeOf	TNFα,production
R13954	T20914	T20915	themeOf	TNFα,synthesis
R13955	T20915	T20913	themeOf	synthesis,activation
R13956	T20921	T20922	themeOf	TNFα,production
R13957	T20924	T20923	themeOf	production,increased
R13958	T20925	T20924	themeOf	TNFα,production

PMC:3585731 / 41607-49868 JSONTXT

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