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PMC:3585731 / 38556-39364 JSONTXT

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testone

Id Subject Object Predicate Lexical cue
T18161 741-745 Protein denotes TNFα
T18160 614-618 Protein denotes RIP1
T18197 568-578 Positive_regulation denotes activation
T18196 326-341 Phosphorylation denotes phosphorylation
T18195 111-121 Positive_regulation denotes activation
T18194 57-67 Gene_expression denotes expression
T18193 22-31 Negative_regulation denotes knockdown
T18192 10-20 Negative_regulation denotes inhibitors

2_test

Id Subject Object Predicate Lexical cue
23469174-22695613-90505454 804-806 22695613 denotes 15

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T18818 806-807 -RRB- denotes ]
T18817 804-806 CD denotes 15
T18816 803-804 -LRB- denotes [
T18815 797-802 NN denotes cells
T18814 792-796 NN denotes L929
T18813 789-791 IN denotes in
T18812 777-788 NN denotes necroptosis
T18811 774-776 IN denotes in
T18810 768-773 NN denotes event
T18712 155-159 NN denotes form
T18711 150-154 DT denotes this
T18710 146-149 IN denotes for
T18709 132-145 JJ denotes indispensable
T18708 129-131 VB denotes is
T18707 125-128 NN denotes Akt
T18706 122-124 IN denotes of
T18705 111-121 NN denotes activation
T18704 99-110 JJ denotes necroptotic
T18703 94-98 IN denotes that
T18702 87-93 VB denotes showed
T18701 84-86 PRP denotes we
T18700 82-83 -COMMA- denotes ,
T18699 75-82 NN denotes mutants
T18698 71-74 NN denotes Akt
T18697 68-70 IN denotes of
T18696 57-67 NN denotes expression
T18695 53-56 DT denotes the
T18694 49-52 CC denotes and
T18693 47-48 -COMMA- denotes ,
T18692 39-47 NN denotes isoforms
T18691 35-38 NN denotes Akt
T18690 32-34 IN denotes of
T18689 22-31 NN denotes knockdown
T18688 20-21 -COMMA- denotes ,
T18687 10-20 NN denotes inhibitors
T18686 6-9 NN denotes Akt
T18685 0-5 VB denotes Using
T18809 759-767 JJ denotes critical
T18808 757-758 DT denotes a
T18807 755-756 -COMMA- denotes ,
T18806 746-755 NN denotes synthesis
T18805 741-745 NN denotes TNFα
T18804 731-740 JJ denotes autocrine
T18803 727-730 CC denotes and
T18802 716-726 NN denotes activation
T18801 712-715 NN denotes JNK
T18800 710-711 -COMMA- denotes ,
T18799 704-710 RB denotes namely
T18798 702-703 -COMMA- denotes ,
T18797 697-702 NN denotes cells
T18796 692-696 NN denotes L929
T18795 680-691 JJ denotes necroptotic
T18794 677-679 IN denotes in
T18793 670-676 NN denotes events
T18792 660-669 NN denotes execution
T18791 656-659 CC denotes and
T18790 646-655 NN denotes signaling
T18789 635-645 JJ denotes downstream
T18788 629-634 VB denotes known
T18787 626-628 TO denotes to
T18786 619-625 NN denotes kinase
T18785 614-618 NN denotes RIP1
T18784 603-613 VB denotes connecting
T18783 598-602 NN denotes link
T18782 590-597 JJ denotes pivotal
T18781 588-589 DT denotes a
T18780 579-587 VB denotes provides
T18779 568-578 NN denotes activation
T18778 564-567 NN denotes Akt
T18777 559-563 IN denotes that
T18776 549-558 VB denotes suggested
T18775 544-548 NN denotes data
T18774 540-543 PRP-DOLLAR- denotes our
T18773 538-539 -COMMA- denotes ,
T18772 532-538 RB denotes Second
T18771 525-530 NN denotes death
T18770 520-524 NN denotes cell
T18769 517-519 TO denotes to
T18768 505-516 VB denotes contributes
T18767 503-504 -COMMA- denotes ,
T18766 499-503 NN denotes turn
T18765 496-498 IN denotes in
T18764 494-495 -COMMA- denotes ,
T18763 489-494 WDT denotes which
T18762 487-488 -COMMA- denotes ,
T18761 480-487 NN denotes pathway
T18760 473-479 NN denotes mTORC1
T18759 469-472 DT denotes the
T18758 466-468 IN denotes as
T18757 461-465 JJ denotes such
T18756 452-460 NN denotes pathways
T18755 443-451 NN denotes effector
T18754 439-442 NN denotes Akt
T18753 435-438 CC denotes and
T18752 424-434 NN denotes substrates
T18751 418-423 JJ denotes known
T18750 415-417 IN denotes of
T18749 408-414 NN denotes number
T18748 406-407 DT denotes a
T18747 398-405 IN denotes towards
T18746 389-397 NN denotes activity
T18745 385-388 PRP-DOLLAR- denotes its
T18744 376-384 VB denotes increase
T18743 373-375 TO denotes to
T18742 362-372 JJ denotes sufficient
T18741 359-361 VB denotes is
T18740 355-358 NN denotes Akt
T18739 352-354 IN denotes of
T18738 345-351 NN denotes Thr308
T18737 342-344 IN denotes of
T18736 326-341 NN denotes phosphorylation
T18735 314-325 JJ denotes necroptotic
T18734 304-313 JJ denotes selective
T18733 299-303 IN denotes that
T18732 286-298 VB denotes demonstrated
T18731 283-285 PRP denotes we
T18730 281-282 -COMMA- denotes ,
T18729 276-281 RB denotes First
T18728 263-274 NN denotes necroptosis
T18727 260-262 TO denotes to
T18726 249-259 VB denotes contribute
T18725 244-248 WDT denotes that
T18724 235-243 NN denotes pathways
T18723 221-234 JJ denotes Akt-dependent
T18722 210-220 JJ denotes downstream
T18721 197-209 VB denotes investigated
T18720 192-196 RB denotes also
T18719 189-191 PRP denotes We
T18718 182-187 NN denotes cells
T18717 177-181 NN denotes L929
T18716 174-176 IN denotes in
T18715 168-173 NN denotes death
T18714 163-167 NN denotes cell
T18713 160-162 IN denotes of
R12333 T18687 T18686 arg1Of inhibitors,Akt
R12334 T18687 T18688 arg1Of inhibitors,","
R12335 T18687 T18694 arg1Of inhibitors,and
R12336 T18689 T18688 arg2Of knockdown,","
R12337 T18689 T18690 arg1Of knockdown,of
R12338 T18692 T18690 arg2Of isoforms,of
R12339 T18692 T18691 arg1Of isoforms,Akt
R12340 T18694 T18685 arg2Of and,Using
R12341 T18694 T18693 arg1Of and,","
R12342 T18696 T18694 arg2Of expression,and
R12343 T18696 T18695 arg1Of expression,the
R12344 T18696 T18697 arg1Of expression,of
R12345 T18699 T18697 arg2Of mutants,of
R12346 T18699 T18698 arg1Of mutants,Akt
R12347 T18701 T18685 arg1Of we,Using
R12348 T18701 T18702 arg1Of we,showed
R12349 T18702 T18685 modOf showed,Using
R12350 T18702 T18700 arg1Of showed,","
R12351 T18705 T18704 arg1Of activation,necroptotic
R12352 T18705 T18706 arg1Of activation,of
R12353 T18705 T18708 arg1Of activation,is
R12354 T18705 T18709 arg1Of activation,indispensable
R12355 T18707 T18706 arg2Of Akt,of
R12356 T18708 T18702 arg2Of is,showed
R12357 T18708 T18703 arg1Of is,that
R12358 T18709 T18708 arg2Of indispensable,is
R12359 T18709 T18710 arg1Of indispensable,for
R12360 T18712 T18710 arg2Of form,for
R12361 T18712 T18711 arg1Of form,this
R12362 T18712 T18713 arg1Of form,of
R12363 T18715 T18713 arg2Of death,of
R12364 T18715 T18714 arg1Of death,cell
R12365 T18715 T18716 arg1Of death,in
R12366 T18718 T18716 arg2Of cells,in
R12367 T18718 T18717 arg1Of cells,L929
R12368 T18719 T18721 arg1Of We,investigated
R12369 T18721 T18720 arg1Of investigated,also
R12370 T18724 T18721 arg2Of pathways,investigated
R12371 T18724 T18722 arg1Of pathways,downstream
R12372 T18724 T18723 arg1Of pathways,Akt-dependent
R12373 T18724 T18725 arg1Of pathways,that
R12374 T18724 T18726 arg1Of pathways,contribute
R12375 T18726 T18727 arg1Of contribute,to
R12376 T18728 T18727 arg2Of necroptosis,to
R12377 T18731 T18732 arg1Of we,demonstrated
R12378 T18732 T18729 arg1Of demonstrated,First
R12379 T18732 T18730 arg1Of demonstrated,","
R12380 T18736 T18734 arg1Of phosphorylation,selective
R12381 T18736 T18735 arg1Of phosphorylation,necroptotic
R12382 T18736 T18737 arg1Of phosphorylation,of
R12383 T18736 T18741 arg1Of phosphorylation,is
R12384 T18736 T18742 arg1Of phosphorylation,sufficient
R12385 T18736 T18744 arg1Of phosphorylation,increase
R12386 T18738 T18737 arg2Of Thr308,of
R12387 T18738 T18739 arg1Of Thr308,of
R12388 T18740 T18739 arg2Of Akt,of
R12389 T18741 T18732 arg2Of is,demonstrated
R12390 T18741 T18733 arg1Of is,that
R12391 T18742 T18741 arg2Of sufficient,is
R12392 T18744 T18742 arg2Of increase,sufficient
R12393 T18744 T18743 arg1Of increase,to
R12394 T18744 T18747 arg1Of increase,towards
R12395 T18746 T18744 arg2Of activity,increase
R12396 T18746 T18745 arg1Of activity,its
R12397 T18749 T18747 arg2Of number,towards
R12398 T18749 T18748 arg1Of number,a
R12399 T18749 T18750 arg1Of number,of
R12400 T18749 T18758 arg1Of number,as
R12401 T18752 T18751 arg1Of substrates,known
R12402 T18752 T18753 arg1Of substrates,and
R12403 T18753 T18750 arg2Of and,of
R12404 T18756 T18753 arg2Of pathways,and
R12405 T18756 T18754 arg1Of pathways,Akt
R12406 T18756 T18755 arg1Of pathways,effector
R12407 T18758 T18757 arg1Of as,such
R12408 T18761 T18758 arg2Of pathway,as
R12409 T18761 T18759 arg1Of pathway,the
R12410 T18761 T18760 arg1Of pathway,mTORC1
R12411 T18761 T18762 arg1Of pathway,","
R12412 T18761 T18763 arg1Of pathway,which
R12413 T18761 T18768 arg1Of pathway,contributes
R12414 T18766 T18765 arg2Of turn,in
R12415 T18768 T18764 arg1Of contributes,","
R12416 T18768 T18765 arg1Of contributes,in
R12417 T18768 T18767 arg1Of contributes,","
R12418 T18768 T18769 arg1Of contributes,to
R12419 T18771 T18769 arg2Of death,to
R12420 T18771 T18770 arg1Of death,cell
R12421 T18775 T18774 arg1Of data,our
R12422 T18775 T18776 arg1Of data,suggested
R12423 T18776 T18772 arg1Of suggested,Second
R12424 T18776 T18773 arg1Of suggested,","
R12425 T18779 T18778 arg1Of activation,Akt
R12426 T18779 T18780 arg1Of activation,provides
R12427 T18780 T18776 arg2Of provides,suggested
R12428 T18780 T18777 arg1Of provides,that
R12429 T18783 T18780 arg2Of link,provides
R12430 T18783 T18781 arg1Of link,a
R12431 T18783 T18782 arg1Of link,pivotal
R12432 T18783 T18784 arg1Of link,connecting
R12433 T18786 T18784 arg2Of kinase,connecting
R12434 T18786 T18785 arg1Of kinase,RIP1
R12435 T18786 T18787 arg1Of kinase,to
R12436 T18790 T18791 arg1Of signaling,and
R12437 T18792 T18791 arg2Of execution,and
R12438 T18793 T18787 arg2Of events,to
R12439 T18793 T18788 arg2Of events,known
R12440 T18793 T18789 arg1Of events,downstream
R12441 T18793 T18790 arg1Of events,signaling
R12442 T18793 T18792 arg1Of events,execution
R12443 T18793 T18794 arg1Of events,in
R12444 T18793 T18798 arg1Of events,","
R12445 T18793 T18799 arg1Of events,namely
R12446 T18793 T18800 arg1Of events,","
R12447 T18793 T18807 arg1Of events,","
R12448 T18797 T18794 arg2Of cells,in
R12449 T18797 T18795 arg1Of cells,necroptotic
R12450 T18797 T18796 arg1Of cells,L929
R12451 T18802 T18801 arg1Of activation,JNK
R12452 T18802 T18803 arg1Of activation,and
R12453 T18803 T18800 arg2Of and,","
R12454 T18806 T18803 arg2Of synthesis,and
R12455 T18806 T18804 arg1Of synthesis,autocrine
R12456 T18806 T18805 arg1Of synthesis,TNFα
R12457 T18810 T18807 arg2Of event,","
R12458 T18810 T18808 arg1Of event,a
R12459 T18810 T18809 arg1Of event,critical
R12460 T18810 T18811 arg1Of event,in
R12461 T18810 T18813 arg1Of event,in
R12462 T18810 T18816 arg1Of event,[
R12463 T18812 T18811 arg2Of necroptosis,in
R12464 T18815 T18813 arg2Of cells,in
R12465 T18815 T18814 arg1Of cells,L929
R12466 T18817 T18816 arg2Of 15,[
R12467 T18818 T18816 arg3Of ],[

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T18395 741-745 Protein denotes TNFα
T18394 614-618 Protein denotes RIP1

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T19385 741-745 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T19378 564-567 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19377 439-442 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19376 355-358 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19375 221-224 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19374 125-128 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19373 71-74 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19372 35-38 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19371 6-9 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19354 355-358 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19353 221-224 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19352 125-128 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19351 71-74 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19350 35-38 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19349 6-9 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19334 564-567 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19333 439-442 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19332 355-358 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19331 221-224 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19330 125-128 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19329 71-74 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19328 35-38 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19327 6-9 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19318 614-618 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T19356 564-567 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19355 439-442 http://www.uniprot.org/uniprot/P31751 denotes Akt

GO-BP

Id Subject Object Predicate Lexical cue
T18467 746-755 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T18464 525-530 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T18463 168-173 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T18461 520-530 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T18460 163-173 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T18446 326-341 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18439 777-788 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T18438 263-274 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T18430 777-788 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T18429 263-274 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T18424 646-655 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18415 712-715 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-MF

Id Subject Object Predicate Lexical cue
T18472 712-715 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-CC

Id Subject Object Predicate Lexical cue
T18490 473-479 http://purl.obolibrary.org/obo/GO_0031931 denotes mTORC1
T18482 182-187 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18484 797-802 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18483 697-702 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T18322 532-808 Sentence denotes Second, our data suggested that Akt activation provides a pivotal link connecting RIP1 kinase to known downstream signaling and execution events in necroptotic L929 cells, namely, JNK activation and autocrine TNFα synthesis, a critical event in necroptosis in L929 cells [15].
T18321 276-531 Sentence denotes First, we demonstrated that selective necroptotic phosphorylation of Thr308 of Akt is sufficient to increase its activity towards a number of known substrates and Akt effector pathways such as the mTORC1 pathway, which, in turn, contributes to cell death.
T18320 189-275 Sentence denotes We also investigated downstream Akt-dependent pathways that contribute to necroptosis.
T18319 0-188 Sentence denotes Using Akt inhibitors, knockdown of Akt isoforms, and the expression of Akt mutants, we showed that necroptotic activation of Akt is indispensable for this form of cell death in L929 cells.
T240 0-188 Sentence denotes Using Akt inhibitors, knockdown of Akt isoforms, and the expression of Akt mutants, we showed that necroptotic activation of Akt is indispensable for this form of cell death in L929 cells.
T241 189-275 Sentence denotes We also investigated downstream Akt-dependent pathways that contribute to necroptosis.
T242 276-531 Sentence denotes First, we demonstrated that selective necroptotic phosphorylation of Thr308 of Akt is sufficient to increase its activity towards a number of known substrates and Akt effector pathways such as the mTORC1 pathway, which, in turn, contributes to cell death.
T243 532-808 Sentence denotes Second, our data suggested that Akt activation provides a pivotal link connecting RIP1 kinase to known downstream signaling and execution events in necroptotic L929 cells, namely, JNK activation and autocrine TNFα synthesis, a critical event in necroptosis in L929 cells [15].

simple1

Id Subject Object Predicate Lexical cue
T18498 741-745 Protein denotes TNFα
T18497 614-618 Protein denotes RIP1

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T19297 746-755 Gene_expression denotes synthesis
T19274 614-618 Protein denotes RIP1
T19275 741-745 Protein denotes TNFα
R12908 T19275 T19297 themeOf TNFα,synthesis

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T19498 741-745 Protein denotes TNFα
T19497 614-618 Protein denotes RIP1
T19520 746-755 Gene_expression denotes synthesis
R12977 T19498 T19520 themeOf TNFα,synthesis

DLUT931

Id Subject Object Predicate Lexical cue
T19431 746-755 Gene_expression denotes synthesis
T19430 603-613 Positive_regulation denotes connecting
T19406 741-745 Protein denotes TNFα
T19405 614-618 Protein denotes RIP1
R12936 T19405 T19430 themeOf RIP1,connecting
R12937 T19406 T19431 themeOf TNFα,synthesis

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T19898 99-128 Positive_regulation denotes necroptotic activation of Akt
T19890 304-358 Phosphorylation denotes selective necroptotic phosphorylation of Thr308 of Akt
T19884 712-726 Positive_regulation denotes JNK activation
T19874 731-755 Protein denotes autocrine TNFα synthesis
T19858 443-468 Entity denotes effector pathways such as
T19851 614-618 Protein denotes RIP1
T19849 415-434 Entity denotes of known substrates
T19846 6-21 Entity denotes Akt inhibitors,
T19843 792-807 Entity denotes L929 cells [15]
T19831 342-358 Entity denotes of Thr308 of Akt
T19829 221-234 Protein denotes Akt-dependent
T19827 68-82 Protein denotes of Akt mutants
T19811 614-655 Protein denotes RIP1 kinase to known downstream signaling
T19810 712-715 Protein denotes JNK
T19802 469-487 Entity denotes the mTORC1 pathway
T19800 35-38 Protein denotes Akt
T19799 559-567 Protein denotes that Akt
T19795 439-442 Protein denotes Akt
T19793 6-9 Protein denotes Akt
T19789 692-696 Entity denotes L929
T19783 680-702 Entity denotes necroptotic L929 cells
T19776 355-358 Protein denotes Akt
T19774 122-128 Protein denotes of Akt
R13122 T19774 T19898 themeOf of Akt,necroptotic activation of Akt
R13123 T19776 T19890 themeOf Akt,selective necroptotic phosphorylation of Thr308 of Akt
R13131 T19810 T19884 themeOf JNK,JNK activation
R13134 T19831 T19776 partOf of Thr308 of Akt,Akt
R13135 T19831 T19890 siteOf of Thr308 of Akt,selective necroptotic phosphorylation of Thr308 of Akt

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T20214 807-808 . denotes .
T20213 806-807 NNP denotes ]
T20212 804-806 CD denotes 15
T20211 803-804 NNP denotes [
T20210 797-802 NNS denotes cells
T20209 792-796 NNP denotes L929
T20208 789-791 IN denotes in
T20207 777-788 NN denotes necroptosis
T20206 774-776 IN denotes in
T20205 768-773 NN denotes event
T20204 759-767 JJ denotes critical
T20203 757-758 DT denotes a
T20202 755-756 , denotes ,
T20201 746-755 NN denotes synthesis
T20200 741-745 NNP denotes TNFα
T20199 731-740 NN denotes autocrine
T20198 727-730 CC denotes and
T20197 716-726 NN denotes activation
T20196 712-715 NNP denotes JNK
T20195 710-711 , denotes ,
T20194 704-710 RB denotes namely
T20193 702-703 , denotes ,
T20192 697-702 NNS denotes cells
T20191 692-696 NNP denotes L929
T20190 680-691 JJ denotes necroptotic
T20189 677-679 IN denotes in
T20188 670-676 NNS denotes events
T20187 660-669 NN denotes execution
T20186 656-659 CC denotes and
T20185 646-655 VBG denotes signaling
T20184 635-645 JJ denotes downstream
T20183 629-634 VBN denotes known
T20182 626-628 TO denotes to
T20181 619-625 NN denotes kinase
T20180 614-618 CD denotes RIP1
T20179 603-613 VBG denotes connecting
T20178 598-602 NN denotes link
T20177 590-597 JJ denotes pivotal
T20176 588-589 DT denotes a
T20175 579-587 VBZ denotes provides
T20174 568-578 NN denotes activation
T20173 564-567 NNP denotes Akt
T20172 559-563 IN denotes that
T20171 549-558 VBD denotes suggested
T20170 544-548 NNS denotes data
T20169 540-543 PRP$ denotes our
T20168 538-539 , denotes ,
T20167 532-538 NNP denotes Second
T20166 530-531 . denotes .
T20165 525-530 NN denotes death
T20164 520-524 NN denotes cell
T20163 517-519 TO denotes to
T20162 505-516 VBZ denotes contributes
T20161 503-504 , denotes ,
T20160 499-503 NN denotes turn
T20159 496-498 IN denotes in
T20158 494-495 , denotes ,
T20157 489-494 WDT denotes which
T20156 487-488 , denotes ,
T20155 480-487 NN denotes pathway
T20154 473-479 NNP denotes mTORC1
T20153 469-472 DT denotes the
T20152 466-468 IN denotes as
T20151 461-465 JJ denotes such
T20150 452-460 NNS denotes pathways
T20149 443-451 NN denotes effector
T20148 439-442 NNP denotes Akt
T20147 435-438 CC denotes and
T20146 424-434 NNS denotes substrates
T20145 418-423 VBN denotes known
T20144 415-417 IN denotes of
T20143 408-414 NN denotes number
T20142 406-407 DT denotes a
T20141 398-405 IN denotes towards
T20140 389-397 NN denotes activity
T20139 385-388 PRP$ denotes its
T20138 376-384 VB denotes increase
T20137 373-375 TO denotes to
T20136 362-372 JJ denotes sufficient
T20135 359-361 VBZ denotes is
T20134 355-358 NNP denotes Akt
T20133 352-354 IN denotes of
T20132 345-351 CD denotes Thr308
T20131 342-344 IN denotes of
T20130 326-341 NN denotes phosphorylation
T20129 314-325 JJ denotes necroptotic
T20128 304-313 JJ denotes selective
T20127 299-303 IN denotes that
T20126 286-298 VBD denotes demonstrated
T20125 283-285 PRP denotes we
T20124 281-282 , denotes ,
T20123 276-281 RB denotes First
T20122 274-275 . denotes .
T20121 263-274 NN denotes necroptosis
T20120 260-262 TO denotes to
T20119 249-259 VBP denotes contribute
T20118 244-248 WDT denotes that
T20117 235-243 NNS denotes pathways
T20116 221-234 JJ denotes Akt-dependent
T20115 210-220 JJ denotes downstream
T20114 197-209 VBD denotes investigated
T20113 192-196 RB denotes also
T20112 189-191 PRP denotes We
T20111 187-188 . denotes .
T20110 182-187 NNS denotes cells
T20109 177-181 CD denotes L929
T20108 174-176 IN denotes in
T20107 168-173 NN denotes death
T20106 163-167 NN denotes cell
T20105 160-162 IN denotes of
T20104 155-159 NN denotes form
T20103 150-154 DT denotes this
T20102 146-149 IN denotes for
T20101 132-145 JJ denotes indispensable
T20100 129-131 VBZ denotes is
T20099 125-128 NNP denotes Akt
T20098 122-124 IN denotes of
T20097 111-121 NN denotes activation
T20096 99-110 JJ denotes necroptotic
T20095 94-98 IN denotes that
T20094 87-93 VBD denotes showed
T20093 84-86 PRP denotes we
T20092 82-83 , denotes ,
T20091 75-82 NNS denotes mutants
T20090 71-74 NNP denotes Akt
T20089 68-70 IN denotes of
T20088 57-67 NN denotes expression
T20087 53-56 DT denotes the
T20086 49-52 CC denotes and
T20085 47-48 , denotes ,
T20084 39-47 VBZ denotes isoforms
T20083 35-38 NNP denotes Akt
T20082 32-34 IN denotes of
T20081 22-31 NN denotes knockdown
T20080 20-21 , denotes ,
T20079 10-20 NNS denotes inhibitors
T20078 6-9 NNP denotes Akt
T20077 0-5 VBG denotes Using
R13328 T20077 T20094 advcl Using,showed
R13329 T20078 T20079 compound Akt,inhibitors
R13330 T20079 T20077 dobj inhibitors,Using
R13331 T20080 T20079 punct ",",inhibitors
R13332 T20081 T20079 appos knockdown,inhibitors
R13333 T20082 T20081 prep of,knockdown
R13334 T20083 T20084 compound Akt,isoforms
R13335 T20084 T20082 pobj isoforms,of
R13336 T20085 T20081 punct ",",knockdown
R13337 T20086 T20081 cc and,knockdown
R13338 T20087 T20088 det the,expression
R13339 T20088 T20081 conj expression,knockdown
R13340 T20089 T20088 prep of,expression
R13341 T20090 T20091 compound Akt,mutants
R13342 T20091 T20089 pobj mutants,of
R13343 T20092 T20094 punct ",",showed
R13344 T20093 T20094 nsubj we,showed
R13345 T20094 T20094 ROOT showed,showed
R13346 T20095 T20100 mark that,is
R13347 T20096 T20097 amod necroptotic,activation
R13348 T20097 T20100 nsubj activation,is
R13349 T20098 T20097 prep of,activation
R13350 T20099 T20098 pobj Akt,of
R13351 T20100 T20094 ccomp is,showed
R13352 T20101 T20100 acomp indispensable,is
R13353 T20102 T20101 prep for,indispensable
R13354 T20103 T20104 det this,form
R13355 T20104 T20102 pobj form,for
R13356 T20105 T20104 prep of,form
R13357 T20106 T20107 compound cell,death
R13358 T20107 T20105 pobj death,of
R13359 T20108 T20100 prep in,is
R13360 T20109 T20110 nummod L929,cells
R13361 T20110 T20108 pobj cells,in
R13362 T20111 T20094 punct .,showed
R13363 T20112 T20114 nsubj We,investigated
R13364 T20113 T20114 advmod also,investigated
R13365 T20114 T20114 ROOT investigated,investigated
R13366 T20115 T20117 amod downstream,pathways
R13367 T20116 T20117 amod Akt-dependent,pathways
R13368 T20117 T20114 dobj pathways,investigated
R13369 T20118 T20119 nsubj that,contribute
R13370 T20119 T20117 relcl contribute,pathways
R13371 T20120 T20121 aux to,necroptosis
R13372 T20121 T20119 xcomp necroptosis,contribute
R13373 T20122 T20114 punct .,investigated
R13374 T20123 T20126 advmod First,demonstrated
R13375 T20124 T20126 punct ",",demonstrated
R13376 T20125 T20126 nsubj we,demonstrated
R13377 T20126 T20126 ROOT demonstrated,demonstrated
R13378 T20127 T20135 mark that,is
R13379 T20128 T20130 amod selective,phosphorylation
R13380 T20129 T20130 amod necroptotic,phosphorylation
R13381 T20130 T20135 nsubj phosphorylation,is
R13382 T20131 T20130 prep of,phosphorylation
R13383 T20132 T20131 pobj Thr308,of
R13384 T20133 T20132 prep of,Thr308
R13385 T20134 T20133 pobj Akt,of
R13386 T20135 T20126 ccomp is,demonstrated
R13387 T20136 T20135 acomp sufficient,is
R13388 T20137 T20138 aux to,increase
R13389 T20138 T20136 xcomp increase,sufficient
R13390 T20139 T20140 poss its,activity
R13391 T20140 T20138 dobj activity,increase
R13392 T20141 T20138 prep towards,increase
R13393 T20142 T20143 det a,number
R13394 T20143 T20141 pobj number,towards
R13395 T20144 T20143 prep of,number
R13396 T20145 T20146 amod known,substrates
R13397 T20146 T20144 pobj substrates,of
R13398 T20147 T20146 cc and,substrates
R13399 T20148 T20150 nmod Akt,pathways
R13400 T20149 T20150 compound effector,pathways
R13401 T20150 T20146 conj pathways,substrates
R13402 T20151 T20152 amod such,as
R13403 T20152 T20150 prep as,pathways
R13404 T20153 T20155 det the,pathway
R13405 T20154 T20155 compound mTORC1,pathway
R13406 T20155 T20152 pobj pathway,as
R13407 T20156 T20155 punct ",",pathway
R13408 T20157 T20162 nsubj which,contributes
R13409 T20158 T20162 punct ",",contributes
R13410 T20159 T20162 prep in,contributes
R13411 T20160 T20159 pobj turn,in
R13412 T20161 T20162 punct ",",contributes
R13413 T20162 T20143 relcl contributes,number
R13414 T20163 T20162 prep to,contributes
R13415 T20164 T20165 compound cell,death
R13416 T20165 T20163 pobj death,to
R13417 T20166 T20126 punct .,demonstrated
R13418 T20167 T20171 advmod Second,suggested
R13419 T20168 T20171 punct ",",suggested
R13420 T20169 T20170 poss our,data
R13421 T20170 T20171 nsubj data,suggested
R13422 T20171 T20171 ROOT suggested,suggested
R13423 T20172 T20175 mark that,provides
R13424 T20173 T20174 compound Akt,activation
R13425 T20174 T20175 nsubj activation,provides
R13426 T20175 T20171 ccomp provides,suggested
R13427 T20176 T20178 det a,link
R13428 T20177 T20178 amod pivotal,link
R13429 T20178 T20175 dobj link,provides
R13430 T20179 T20178 acl connecting,link
R13431 T20180 T20181 nummod RIP1,kinase
R13432 T20181 T20179 dobj kinase,connecting
R13433 T20182 T20179 prep to,connecting
R13434 T20183 T20185 amod known,signaling
R13435 T20184 T20185 amod downstream,signaling
R13436 T20185 T20182 pobj signaling,to
R13437 T20186 T20185 cc and,signaling
R13438 T20187 T20188 compound execution,events
R13439 T20188 T20185 conj events,signaling
R13440 T20189 T20188 prep in,events
R13441 T20190 T20192 amod necroptotic,cells
R13442 T20191 T20192 compound L929,cells
R13443 T20192 T20189 pobj cells,in
R13444 T20193 T20192 punct ",",cells
R13445 T20194 T20197 advmod namely,activation
R13446 T20195 T20197 punct ",",activation
R13447 T20196 T20197 compound JNK,activation
R13448 T20197 T20192 conj activation,cells
R13449 T20198 T20197 cc and,activation
R13450 T20199 T20197 conj autocrine,activation
R13451 T20200 T20201 compound TNFα,synthesis
R13452 T20201 T20197 conj synthesis,activation
R13453 T20202 T20197 punct ",",activation
R13454 T20203 T20205 det a,event
R13455 T20204 T20205 amod critical,event
R13456 T20205 T20197 conj event,activation
R13457 T20206 T20205 prep in,event
R13458 T20207 T20206 pobj necroptosis,in
R13459 T20208 T20205 prep in,event
R13460 T20209 T20210 compound L929,cells
R13461 T20210 T20208 pobj cells,in
R13462 T20211 T20213 nmod [,]
R13463 T20212 T20213 nummod 15,]
R13464 T20213 T20205 appos ],event
R13465 T20214 T20171 punct .,suggested

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T19575 35-38 Protein denotes Akt
T19574 6-9 Protein denotes Akt
T19599 716-726 Positive_regulation denotes activation
T19598 603-613 Positive_regulation denotes connecting
T19597 746-755 Gene_expression denotes synthesis
T19596 716-726 Positive_regulation denotes activation
T19595 568-578 Positive_regulation denotes activation
T19594 731-745 Protein denotes autocrine TNFα
T19593 712-715 Protein denotes JNK
T19592 614-625 Protein denotes RIP1 kinase
T19591 564-567 Protein denotes Akt
T19590 326-341 Phosphorylation denotes phosphorylation
T19589 326-341 Phosphorylation denotes phosphorylation
T19588 473-479 Protein denotes mTORC1
T19587 355-358 Protein denotes Akt
T19586 345-351 Protein denotes Thr308
T19585 10-20 Negative_regulation denotes inhibitors
T19584 0-5 Negative_regulation denotes Using
T19583 0-5 Negative_regulation denotes Using
T19582 0-5 Negative_regulation denotes Using
T19581 111-121 Positive_regulation denotes activation
T19580 57-67 Gene_expression denotes expression
T19579 22-31 Negative_regulation denotes knockdown
T19578 10-20 Negative_regulation denotes inhibitors
T19577 125-128 Protein denotes Akt
T19576 71-82 Protein denotes Akt mutants
R13019 T19574 T19578 themeOf Akt,inhibitors
R13020 T19575 T19579 themeOf Akt,knockdown
R13021 T19576 T19580 themeOf Akt mutants,expression
R13022 T19577 T19581 themeOf Akt,activation
R13023 T19578 T19582 themeOf inhibitors,Using
R13024 T19579 T19583 themeOf knockdown,Using
R13025 T19580 T19584 themeOf expression,Using
R13026 T19580 T19585 themeOf expression,inhibitors
R13027 T19586 T19589 themeOf Thr308,phosphorylation
R13028 T19587 T19590 themeOf Akt,phosphorylation
R13029 T19591 T19595 themeOf Akt,activation
R13030 T19593 T19596 themeOf JNK,activation
R13031 T19594 T19597 themeOf autocrine TNFα,synthesis
R13032 T19596 T19598 themeOf activation,connecting
R13033 T19597 T19599 themeOf synthesis,activation

test3

Id Subject Object Predicate Lexical cue
T18268 746-755 Gene_expression denotes synthesis
T18267 741-745 Protein denotes TNFα
T18266 731-740 Regulation denotes autocrine
T18265 614-618 Protein denotes RIP1
T18264 326-341 Phosphorylation denotes phosphorylation
T18263 111-121 Positive_regulation denotes activation
T18262 57-67 Gene_expression denotes expression
T18261 22-31 Negative_regulation denotes knockdown
T18260 10-20 Negative_regulation denotes inhibitors
T18227 741-745 Protein denotes TNFα
T18226 614-618 Protein denotes RIP1
R12110 T18267 T18268 themeOf TNFα,synthesis
R12111 T18268 T18266 themeOf synthesis,autocrine