> top > docs > PMC:3585731 > spans > 38085-38555 > annotations

PMC:3585731 / 38085-38555 JSONTXT

Annnotations TAB JSON ListView MergeView

testone

Id Subject Object Predicate Lexical cue
T32289 338-353 Phosphorylation denotes phosphorylation
T32288 328-333 Positive_regulation denotes leads
T32287 286-296 Positive_regulation denotes Activation
T32286 122-137 Phosphorylation denotes phosphorylation
T32285 270-274 Protein denotes TNFα
T32284 212-216 Protein denotes RIP1
T32283 53-57 Protein denotes RIP1
R22253 T32289 T32288 themeOf phosphorylation,leads

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T32399 464-469 NN denotes cells
T32398 459-463 NN denotes L929
T32397 456-458 IN denotes in
T32396 450-455 NN denotes death
T32395 438-449 JJ denotes necroptotic
T32394 435-437 IN denotes of
T32393 425-434 NN denotes execution
T32392 421-424 DT denotes the
T32391 418-420 TO denotes to
T32390 407-417 VB denotes contribute
T32389 401-406 WDT denotes which
T32388 399-400 -COMMA- denotes ,
T32387 395-399 NN denotes mTOR
T32386 392-394 IN denotes as
T32385 387-391 JJ denotes such
T32384 385-386 -COMMA- denotes ,
T32383 375-385 NN denotes substrates
T32382 371-374 NN denotes Akt
T32381 365-370 VB denotes known
T32380 357-364 JJ denotes several
T32379 354-356 IN denotes of
T32378 338-353 NN denotes phosphorylation
T32377 334-337 DT denotes the
T32376 328-333 VB denotes leads
T32375 323-327 RB denotes also
T32374 311-322 NN denotes necroptosis
T32373 304-310 IN denotes during
T32372 300-303 NN denotes Akt
T32371 297-299 IN denotes of
T32370 286-296 NN denotes Activation
T32369 275-284 NN denotes synthesis
T32368 270-274 NN denotes TNFα
T32367 267-269 TO denotes to
T32366 261-266 VB denotes leads
T32365 250-260 NN denotes activation
T32364 246-249 NN denotes JNK
T32363 244-245 -COMMA- denotes ,
T32362 241-244 NN denotes Akt
T32361 236-240 IN denotes from
T32360 225-235 NN denotes Downstream
T32359 217-223 NN denotes kinase
T32358 212-216 NN denotes RIP1
T32357 208-211 CC denotes and
T32356 200-207 NN denotes factors
T32355 193-199 NN denotes growth
T32354 188-192 DT denotes both
T32353 183-187 IN denotes from
T32352 176-182 NN denotes inputs
T32351 167-175 VB denotes requires
T32350 155-166 NN denotes necroptosis
T32349 148-154 IN denotes during
T32348 141-147 NN denotes Thr308
T32347 138-140 IN denotes at
T32346 122-137 NN denotes phosphorylation
T32345 118-121 NN denotes Akt
T32344 111-116 NN denotes cells
T32343 106-110 NN denotes L929
T32342 94-105 JJ denotes necroptotic
T32341 91-93 IN denotes in
T32340 81-90 NN denotes signaling
T32339 71-80 JJ denotes dependent
T32338 67-70 NN denotes JNK
T32337 63-66 CC denotes and
T32336 59-62 NN denotes Akt
T32335 57-58 -COMMA- denotes ,
T32334 53-57 NN denotes RIP1
T32333 50-52 IN denotes of
T32332 44-49 NN denotes Model
R22259 T32332 T32333 arg1Of Model,of
R22260 T32332 T32341 arg1Of Model,in
R22261 T32334 T32335 arg1Of RIP1,","
R22262 T32335 T32337 arg1Of ",",and
R22263 T32336 T32335 arg2Of Akt,","
R22264 T32337 T32333 arg2Of and,of
R22265 T32339 T32338 arg1Of dependent,JNK
R22266 T32340 T32337 arg2Of signaling,and
R22267 T32340 T32339 arg1Of signaling,dependent
R22268 T32344 T32341 arg2Of cells,in
R22269 T32344 T32342 arg1Of cells,necroptotic
R22270 T32344 T32343 arg1Of cells,L929
R22271 T32346 T32345 arg1Of phosphorylation,Akt
R22272 T32346 T32347 arg1Of phosphorylation,at
R22273 T32346 T32349 arg1Of phosphorylation,during
R22274 T32346 T32351 arg1Of phosphorylation,requires
R22275 T32348 T32347 arg2Of Thr308,at
R22276 T32350 T32349 arg2Of necroptosis,during
R22277 T32352 T32351 arg2Of inputs,requires
R22278 T32352 T32353 arg1Of inputs,from
R22279 T32356 T32355 arg1Of factors,growth
R22280 T32356 T32357 arg1Of factors,and
R22281 T32357 T32353 arg2Of and,from
R22282 T32357 T32354 arg1Of and,both
R22283 T32359 T32357 arg2Of kinase,and
R22284 T32359 T32358 arg1Of kinase,RIP1
R22285 T32360 T32361 arg1Of Downstream,from
R22286 T32362 T32361 arg2Of Akt,from
R22287 T32365 T32364 arg1Of activation,JNK
R22288 T32365 T32366 arg1Of activation,leads
R22289 T32366 T32360 arg1Of leads,Downstream
R22290 T32366 T32363 arg1Of leads,","
R22291 T32366 T32367 arg1Of leads,to
R22292 T32369 T32367 arg2Of synthesis,to
R22293 T32369 T32368 arg1Of synthesis,TNFα
R22294 T32370 T32371 arg1Of Activation,of
R22295 T32370 T32373 arg1Of Activation,during
R22296 T32370 T32376 arg1Of Activation,leads
R22297 T32372 T32371 arg2Of Akt,of
R22298 T32374 T32373 arg2Of necroptosis,during
R22299 T32376 T32375 arg1Of leads,also
R22300 T32378 T32376 arg2Of phosphorylation,leads
R22301 T32378 T32377 arg1Of phosphorylation,the
R22302 T32378 T32379 arg1Of phosphorylation,of
R22303 T32383 T32379 arg2Of substrates,of
R22304 T32383 T32380 arg1Of substrates,several
R22305 T32383 T32381 arg2Of substrates,known
R22306 T32383 T32382 arg1Of substrates,Akt
R22307 T32383 T32384 arg1Of substrates,","
R22308 T32383 T32386 arg1Of substrates,as
R22309 T32386 T32385 arg1Of as,such
R22310 T32387 T32386 arg2Of mTOR,as
R22311 T32387 T32388 arg1Of mTOR,","
R22312 T32387 T32389 arg1Of mTOR,which
R22313 T32387 T32390 arg1Of mTOR,contribute
R22314 T32390 T32391 arg1Of contribute,to
R22315 T32393 T32391 arg2Of execution,to
R22316 T32393 T32392 arg1Of execution,the
R22317 T32393 T32394 arg1Of execution,of
R22318 T32393 T32397 arg1Of execution,in
R22319 T32396 T32394 arg2Of death,of
R22320 T32396 T32395 arg1Of death,necroptotic
R22321 T32399 T32397 arg2Of cells,in
R22322 T32399 T32398 arg1Of cells,L929

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T32312 270-274 Protein denotes TNFα
T32311 212-216 Protein denotes RIP1
T32310 53-57 Protein denotes RIP1

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T32426 395-399 http://www.uniprot.org/uniprot/P42345 denotes mTOR
T32425 270-274 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T32424 371-374 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T32423 300-303 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T32422 241-244 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T32421 118-121 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T32420 59-62 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T32419 371-374 http://www.uniprot.org/uniprot/P31751 denotes Akt
T32418 300-303 http://www.uniprot.org/uniprot/P31751 denotes Akt
T32417 241-244 http://www.uniprot.org/uniprot/P31751 denotes Akt
T32416 118-121 http://www.uniprot.org/uniprot/P31751 denotes Akt
T32415 59-62 http://www.uniprot.org/uniprot/P31751 denotes Akt
T32414 371-374 http://www.uniprot.org/uniprot/P31749 denotes Akt
T32413 300-303 http://www.uniprot.org/uniprot/P31749 denotes Akt
T32412 241-244 http://www.uniprot.org/uniprot/P31749 denotes Akt
T32411 118-121 http://www.uniprot.org/uniprot/P31749 denotes Akt
T32410 59-62 http://www.uniprot.org/uniprot/P31749 denotes Akt
T32409 212-216 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T32408 53-57 http://www.uniprot.org/uniprot/Q13546 denotes RIP1

GO-BP

Id Subject Object Predicate Lexical cue
T32324 450-455 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T32323 275-284 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T32322 193-199 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T32321 311-322 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T32320 155-166 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T32319 311-322 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T32318 155-166 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T32317 338-353 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T32316 122-137 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T32315 81-90 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T32314 246-249 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T32313 67-70 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-MF

Id Subject Object Predicate Lexical cue
T32326 246-249 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T32325 67-70 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-CC

Id Subject Object Predicate Lexical cue
T32328 464-469 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T32327 111-116 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T32304 286-470 Sentence denotes Activation of Akt during necroptosis also leads the phosphorylation of several known Akt substrates, such as mTOR, which contribute to the execution of necroptotic death in L929 cells.
T32303 225-285 Sentence denotes Downstream from Akt, JNK activation leads to TNFα synthesis.
T32302 118-224 Sentence denotes Akt phosphorylation at Thr308 during necroptosis requires inputs from both growth factors and RIP1 kinase.
T32301 44-117 Sentence denotes Model of RIP1, Akt and JNK dependent signaling in necroptotic L929 cells.
T236 0-117 Sentence denotes 10.1371/journal.pone.0056576.g009 Figure 9 Model of RIP1, Akt and JNK dependent signaling in necroptotic L929 cells.
T237 118-224 Sentence denotes Akt phosphorylation at Thr308 during necroptosis requires inputs from both growth factors and RIP1 kinase.
T238 225-285 Sentence denotes Downstream from Akt, JNK activation leads to TNFα synthesis.
T239 286-470 Sentence denotes Activation of Akt during necroptosis also leads the phosphorylation of several known Akt substrates, such as mTOR, which contribute to the execution of necroptotic death in L929 cells.

simple1

Id Subject Object Predicate Lexical cue
T32331 270-274 Protein denotes TNFα
T32330 212-216 Protein denotes RIP1
T32329 53-57 Protein denotes RIP1

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T32407 275-284 Gene_expression denotes synthesis
T32406 261-266 Positive_regulation denotes leads
T32405 270-274 Protein denotes TNFα
T32404 212-216 Protein denotes RIP1
T32403 53-57 Protein denotes RIP1
R22323 T32405 T32407 themeOf TNFα,synthesis
R22324 T32407 T32406 themeOf synthesis,leads

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T32439 261-266 Positive_regulation denotes leads
T32438 275-284 Gene_expression denotes synthesis
T32437 270-274 Protein denotes TNFα
T32436 212-216 Protein denotes RIP1
T32435 53-57 Protein denotes RIP1
R22327 T32437 T32438 themeOf TNFα,synthesis
R22328 T32438 T32439 themeOf synthesis,leads

DLUT931

Id Subject Object Predicate Lexical cue
T32431 261-266 Positive_regulation denotes leads
T32430 275-284 Gene_expression denotes synthesis
T32429 270-274 Protein denotes TNFα
T32428 212-216 Protein denotes RIP1
T32427 53-57 Protein denotes RIP1
R22325 T32429 T32430 themeOf TNFα,synthesis
R22326 T32430 T32431 themeOf synthesis,leads

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T32572 334-399 Phosphorylation denotes the phosphorylation of several known Akt substrates, such as mTOR
T32571 118-166 Phosphorylation denotes Akt phosphorylation at Thr308 during necroptosis
T32570 118-223 Regulation denotes Akt phosphorylation at Thr308 during necroptosis requires inputs from both growth factors and RIP1 kinase
T32569 286-322 Positive_regulation denotes Activation of Akt during necroptosis
T32568 67-90 Positive_regulation denotes JNK dependent signaling
T32567 241-245 Protein denotes Akt,
T32566 354-399 Protein denotes of several known Akt substrates, such as mTOR
T32565 94-116 Entity denotes necroptotic L929 cells
T32564 297-303 Protein denotes of Akt
T32563 106-110 Entity denotes L929
T32562 357-394 Entity denotes several known Akt substrates, such as
T32561 267-284 Protein denotes to TNFα synthesis
T32560 118-121 Protein denotes Akt
T32559 141-147 Entity denotes Thr308
T32558 371-374 Protein denotes Akt
T32557 53-57 Protein denotes RIP1
T32556 212-216 Protein denotes RIP1
T32555 241-260 Protein denotes Akt, JNK activation
T32554 59-62 Protein denotes Akt
T32553 212-223 Protein denotes RIP1 kinase
T32552 67-70 Protein denotes JNK
R22423 T32552 T32568 causeOf JNK,JNK dependent signaling
R22424 T32559 T32560 partOf Thr308,Akt
R22425 T32559 T32571 siteOf Thr308,Akt phosphorylation at Thr308 during necroptosis
R22426 T32560 T32571 themeOf Akt,Akt phosphorylation at Thr308 during necroptosis
R22427 T32564 T32569 themeOf of Akt,Activation of Akt during necroptosis
R22428 T32566 T32572 themeOf "of several known Akt substrates, such as mTOR","the phosphorylation of several known Akt substrates, such as mTOR"
R22429 T32571 T32570 themeOf Akt phosphorylation at Thr308 during necroptosis,Akt phosphorylation at Thr308 during necroptosis requires inputs from both growth factors and RIP1 kinase

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T32515 385-386 , denotes ,
T32514 375-385 VBZ denotes substrates
T32513 371-374 NNP denotes Akt
T32512 365-370 VBN denotes known
T32511 357-364 JJ denotes several
T32510 354-356 IN denotes of
T32509 338-353 NN denotes phosphorylation
T32508 334-337 DT denotes the
T32507 328-333 VBZ denotes leads
T32506 323-327 RB denotes also
T32505 311-322 NN denotes necroptosis
T32504 304-310 IN denotes during
T32503 300-303 NNP denotes Akt
T32502 297-299 IN denotes of
T32501 286-296 NNP denotes Activation
T32500 284-285 . denotes .
T32499 275-284 NN denotes synthesis
T32498 270-274 VB denotes TNFα
T32497 267-269 TO denotes to
T32496 261-266 VBZ denotes leads
T32495 250-260 NN denotes activation
T32494 246-249 NNP denotes JNK
T32493 244-245 , denotes ,
T32492 241-244 NNP denotes Akt
T32491 236-240 IN denotes from
T32490 225-235 NNP denotes Downstream
T32489 223-224 . denotes .
T32488 217-223 NN denotes kinase
T32487 212-216 CD denotes RIP1
T32486 208-211 CC denotes and
T32485 200-207 NNS denotes factors
T32484 193-199 NN denotes growth
T32483 188-192 DT denotes both
T32482 183-187 IN denotes from
T32481 176-182 NNS denotes inputs
T32480 167-175 VBZ denotes requires
T32479 155-166 NN denotes necroptosis
T32478 148-154 IN denotes during
T32477 141-147 CD denotes Thr308
T32476 138-140 IN denotes at
T32475 122-137 NN denotes phosphorylation
T32474 118-121 NNP denotes Akt
T32473 116-117 . denotes .
T32472 111-116 NNS denotes cells
T32471 106-110 NNP denotes L929
T32470 94-105 JJ denotes necroptotic
T32469 91-93 IN denotes in
T32468 81-90 VBG denotes signaling
T32467 71-80 JJ denotes dependent
T32466 67-70 NNP denotes JNK
T32465 63-66 CC denotes and
T32464 59-62 NNP denotes Akt
T32463 57-58 , denotes ,
T32462 53-57 NNP denotes RIP1
T32461 50-52 IN denotes of
T32460 44-49 NNP denotes Model
T32531 469-470 . denotes .
T32530 464-469 NNS denotes cells
T32529 459-463 CD denotes L929
T32528 456-458 IN denotes in
T32527 450-455 NN denotes death
T32526 438-449 JJ denotes necroptotic
T32525 435-437 IN denotes of
T32524 425-434 NN denotes execution
T32523 421-424 DT denotes the
T32522 418-420 TO denotes to
T32521 407-417 VBP denotes contribute
T32520 401-406 WDT denotes which
T32519 399-400 , denotes ,
T32518 395-399 NNP denotes mTOR
T32517 392-394 IN denotes as
T32516 387-391 JJ denotes such
R22340 T32460 T32468 nsubj Model,signaling
R22341 T32461 T32460 prep of,Model
R22342 T32462 T32461 pobj RIP1,of
R22343 T32463 T32462 punct ",",RIP1
R22344 T32464 T32462 conj Akt,RIP1
R22345 T32465 T32464 cc and,Akt
R22346 T32466 T32464 conj JNK,Akt
R22347 T32467 T32468 amod dependent,signaling
R22348 T32468 T32468 ROOT signaling,signaling
R22349 T32469 T32468 prep in,signaling
R22350 T32470 T32472 amod necroptotic,cells
R22351 T32471 T32472 compound L929,cells
R22352 T32472 T32469 pobj cells,in
R22353 T32473 T32468 punct .,signaling
R22354 T32474 T32475 compound Akt,phosphorylation
R22355 T32475 T32480 nsubj phosphorylation,requires
R22356 T32476 T32475 prep at,phosphorylation
R22357 T32477 T32476 pobj Thr308,at
R22358 T32478 T32480 prep during,requires
R22359 T32479 T32478 pobj necroptosis,during
R22360 T32480 T32480 ROOT requires,requires
R22361 T32481 T32480 dobj inputs,requires
R22362 T32482 T32481 prep from,inputs
R22363 T32483 T32485 det both,factors
R22364 T32484 T32485 compound growth,factors
R22365 T32485 T32482 pobj factors,from
R22366 T32486 T32485 cc and,factors
R22367 T32487 T32488 nummod RIP1,kinase
R22368 T32488 T32485 conj kinase,factors
R22369 T32489 T32480 punct .,requires
R22370 T32490 T32496 nsubj Downstream,leads
R22371 T32491 T32490 prep from,Downstream
R22372 T32492 T32491 pobj Akt,from
R22373 T32493 T32490 punct ",",Downstream
R22374 T32494 T32495 compound JNK,activation
R22375 T32495 T32496 nsubj activation,leads
R22376 T32496 T32496 ROOT leads,leads
R22377 T32497 T32498 aux to,TNFα
R22378 T32498 T32496 xcomp TNFα,leads
R22379 T32499 T32498 dobj synthesis,TNFα
R22380 T32500 T32496 punct .,leads
R22381 T32501 T32507 nsubj Activation,leads
R22382 T32502 T32501 prep of,Activation
R22383 T32503 T32502 pobj Akt,of
R22384 T32504 T32507 prep during,leads
R22385 T32505 T32504 pobj necroptosis,during
R22386 T32506 T32507 advmod also,leads
R22387 T32507 T32507 ROOT leads,leads
R22388 T32508 T32509 det the,phosphorylation
R22389 T32509 T32507 dobj phosphorylation,leads
R22390 T32510 T32509 prep of,phosphorylation
R22391 T32511 T32514 amod several,substrates
R22392 T32512 T32514 amod known,substrates
R22393 T32513 T32514 compound Akt,substrates
R22394 T32514 T32510 pobj substrates,of
R22395 T32515 T32514 punct ",",substrates
R22396 T32516 T32517 amod such,as
R22397 T32517 T32509 prep as,phosphorylation
R22398 T32518 T32517 pobj mTOR,as
R22399 T32519 T32518 punct ",",mTOR
R22400 T32520 T32521 nsubj which,contribute
R22401 T32521 T32509 relcl contribute,phosphorylation
R22402 T32522 T32521 prep to,contribute
R22403 T32523 T32524 det the,execution
R22404 T32524 T32522 pobj execution,to
R22405 T32525 T32524 prep of,execution
R22406 T32526 T32527 amod necroptotic,death
R22407 T32527 T32525 pobj death,of
R22408 T32528 T32524 prep in,execution
R22409 T32529 T32530 nummod L929,cells
R22410 T32530 T32528 pobj cells,in
R22411 T32531 T32507 punct .,leads

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T32449 270-274 Protein denotes TNFα
T32448 246-249 Protein denotes JNK
T32447 241-244 Protein denotes Akt
T32446 167-175 Positive_regulation denotes requires
T32445 122-137 Phosphorylation denotes phosphorylation
T32444 212-223 Protein denotes RIP1 kinase
T32443 118-121 Protein denotes Akt
T32442 67-70 Protein denotes JNK
T32441 59-62 Protein denotes Akt
T32440 53-57 Protein denotes RIP1
T32459 328-333 Positive_regulation denotes leads
T32458 328-333 Positive_regulation denotes leads
T32457 338-353 Phosphorylation denotes phosphorylation
T32456 338-353 Phosphorylation denotes phosphorylation
T32455 286-296 Positive_regulation denotes Activation
T32454 395-399 Protein denotes mTOR
T32453 371-374 Protein denotes Akt
T32452 300-303 Protein denotes Akt
T32451 275-284 Gene_expression denotes synthesis
T32450 250-260 Positive_regulation denotes activation
R22329 T32443 T32445 themeOf Akt,phosphorylation
R22330 T32445 T32446 themeOf phosphorylation,requires
R22331 T32448 T32450 themeOf JNK,activation
R22332 T32449 T32451 themeOf TNFα,synthesis
R22333 T32452 T32455 themeOf Akt,Activation
R22334 T32453 T32456 themeOf Akt,phosphorylation
R22335 T32454 T32457 themeOf mTOR,phosphorylation
R22336 T32455 T32458 causeOf Activation,leads
R22337 T32455 T32459 causeOf Activation,leads
R22338 T32456 T32458 themeOf phosphorylation,leads
R22339 T32457 T32459 themeOf phosphorylation,leads

test3

Id Subject Object Predicate Lexical cue
T32300 338-353 Phosphorylation denotes phosphorylation
T32299 328-333 Positive_regulation denotes leads
T32298 286-296 Positive_regulation denotes Activation
T32297 275-284 Gene_expression denotes synthesis
T32296 270-274 Protein denotes TNFα
T32295 212-216 Protein denotes RIP1
T32294 122-137 Phosphorylation denotes phosphorylation
T32293 53-57 Protein denotes RIP1
T32292 270-274 Protein denotes TNFα
T32291 212-216 Protein denotes RIP1
T32290 53-57 Protein denotes RIP1
R22254 T32296 T32297 themeOf TNFα,synthesis
R22255 T32298 T32299 causeOf Activation,leads
R22256 T32300 T32299 themeOf phosphorylation,leads