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PMC:3585731 / 37015-41605 JSONTXT

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testone

Id Subject Object Predicate Lexical cue
T32289 1408-1423 Phosphorylation denotes phosphorylation
T32288 1398-1403 Positive_regulation denotes leads
T32287 1356-1366 Positive_regulation denotes Activation
T32286 1192-1207 Phosphorylation denotes phosphorylation
T32285 1340-1344 Protein denotes TNFα
T32284 1282-1286 Protein denotes RIP1
T32283 1123-1127 Protein denotes RIP1
T18170 3369-3373 Protein denotes TNFα
T18169 3270-3275 Protein denotes c-Jun
T18168 3187-3188 Protein denotes 2
T18167 3182-3186 Protein denotes JNK1
T18166 3113-3117 Protein denotes JNK2
T18165 3104-3108 Protein denotes JNK1
T18164 2836-2840 Protein denotes PDK1
T18163 2805-2818 Protein denotes p110δ subunit
T18162 2564-2568 Protein denotes TNFα
T18161 2282-2286 Protein denotes TNFα
T18160 2155-2159 Protein denotes RIP1
T18159 898-902 Protein denotes RIP1
T18158 822-829 Protein denotes Myr-Akt
T18157 735-742 Protein denotes Myr-Akt
T18156 359-363 Protein denotes RIP1
T18155 103-107 Protein denotes RIP1
T18154 9-13 Protein denotes RIP1
T18219 4392-4407 Phosphorylation denotes phosphorylation
T18218 4159-4168 Regulation denotes dependent
T18217 4039-4047 Positive_regulation denotes increase
T18216 3963-3973 Positive_regulation denotes activation
T18215 3857-3866 Regulation denotes autocrine
T18214 3807-3814 Negative_regulation denotes reduced
T18213 3787-3802 Phosphorylation denotes phosphorylation
T18212 3732-3741 Negative_regulation denotes knockdown
T18211 3374-3384 Gene_expression denotes production
T18210 3356-3365 Negative_regulation denotes reduction
T18209 3251-3266 Phosphorylation denotes phosphorylation
T18208 3236-3246 Negative_regulation denotes inhibiting
T18207 3197-3212 Phosphorylation denotes phosphorylation
T18206 3169-3178 Negative_regulation denotes knockdown
T18205 2904-2919 Phosphorylation denotes phosphorylation
T18204 2886-2893 Negative_regulation denotes inhibit
T18203 2793-2800 Negative_regulation denotes inhibit
T18202 2642-2657 Phosphorylation denotes phosphorylation
T18201 2602-2611 Negative_regulation denotes inhibited
T18200 2569-2579 Gene_expression denotes production
T18199 2554-2563 Negative_regulation denotes inhibited
T18198 2402-2417 Phosphorylation denotes phosphorylation
T18197 2109-2119 Positive_regulation denotes activation
T18196 1867-1882 Phosphorylation denotes phosphorylation
T18195 1652-1662 Positive_regulation denotes activation
T18194 1598-1608 Gene_expression denotes expression
T18193 1563-1572 Negative_regulation denotes knockdown
T18192 1551-1561 Negative_regulation denotes inhibitors
T18191 972-986 Positive_regulation denotes in response to
T18190 949-964 Phosphorylation denotes phosphorylation
T18189 929-937 Positive_regulation denotes required
T18188 808-818 Gene_expression denotes expression
T18187 671-681 Gene_expression denotes Expression
T18186 650-662 Localization denotes localization
T18185 621-626 Positive_regulation denotes leads
T18184 594-601 Positive_regulation denotes induced
T18183 514-529 Phosphorylation denotes phosphorylation
T18182 415-430 Phosphorylation denotes phosphorylation
T18181 399-407 Positive_regulation denotes increase
T18180 378-383 Positive_regulation denotes leads
T18179 4411-4416 Protein denotes c-Jun
T18178 4252-4257 Protein denotes c-Jun
T18177 4125-4129 Protein denotes TNFα
T18176 4072-4077 Protein denotes c-Jun
T18175 3897-3902 Protein denotes c-Jun
T18174 3867-3871 Protein denotes TNFα
T18173 3720-3725 Protein denotes c-Jun
T18172 3647-3651 Protein denotes TNFα
T18171 3612-3617 Protein denotes c-Jun
R12082 T18157 T18187 themeOf Myr-Akt,Expression
R12083 T18158 T18188 themeOf Myr-Akt,expression
R12084 T18162 T18200 themeOf TNFα,production
R12085 T18163 T18203 themeOf p110δ subunit,inhibit
R12086 T18164 T18203 themeOf PDK1,inhibit
R12087 T18167 T18206 themeOf JNK1,knockdown
R12088 T18168 T18206 themeOf 2,knockdown
R12089 T18169 T18209 themeOf c-Jun,phosphorylation
R12090 T18170 T18211 themeOf TNFα,production
R12091 T18173 T18212 themeOf c-Jun,knockdown
R12092 T18175 T18215 causeOf c-Jun,autocrine
R12093 T18176 T18217 themeOf c-Jun,increase
R12094 T18179 T18219 themeOf c-Jun,phosphorylation
R12095 T18181 T18180 themeOf increase,leads
R12096 T18182 T18181 themeOf phosphorylation,increase
R12097 T18186 T18185 themeOf localization,leads
R12098 T18190 T18191 themeOf phosphorylation,in response to
R12099 T18190 T18189 themeOf phosphorylation,required
R12100 T18200 T18199 themeOf production,inhibited
R12101 T18202 T18201 themeOf phosphorylation,inhibited
R12102 T18205 T18204 themeOf phosphorylation,inhibit
R12103 T18209 T18208 themeOf phosphorylation,inhibiting
R12104 T18211 T18210 themeOf production,reduction
R12105 T18213 T18214 themeOf phosphorylation,reduced
R22253 T32289 T32288 themeOf phosphorylation,leads

2_test

Id Subject Object Predicate Lexical cue
23469174-22695613-90505454 2345-2347 22695613 denotes 15
23469174-19106158-90505455 2828-2830 19106158 denotes 41
23469174-17850214-90505456 2842-2844 17850214 denotes 42
23469174-22037377-90505457 3080-3082 22037377 denotes 43
23469174-20539307-90505458 3663-3665 20539307 denotes 13
23469174-15131264-90505459 3669-3671 15131264 denotes 14
23469174-22695613-90505460 3675-3677 22695613 denotes 15
23469174-19118012-90505461 4455-4457 19118012 denotes 44

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T32399 1534-1539 NN denotes cells
T32398 1529-1533 NN denotes L929
T32397 1526-1528 IN denotes in
T32396 1520-1525 NN denotes death
T32395 1508-1519 JJ denotes necroptotic
T32394 1505-1507 IN denotes of
T32393 1495-1504 NN denotes execution
T32392 1491-1494 DT denotes the
T32391 1488-1490 TO denotes to
T32390 1477-1487 VB denotes contribute
T32389 1471-1476 WDT denotes which
T32388 1469-1470 -COMMA- denotes ,
T32387 1465-1469 NN denotes mTOR
T32386 1462-1464 IN denotes as
T32385 1457-1461 JJ denotes such
T32384 1455-1456 -COMMA- denotes ,
T32383 1445-1455 NN denotes substrates
T32382 1441-1444 NN denotes Akt
T32381 1435-1440 VB denotes known
T32380 1427-1434 JJ denotes several
T32379 1424-1426 IN denotes of
T32378 1408-1423 NN denotes phosphorylation
T32377 1404-1407 DT denotes the
T32376 1398-1403 VB denotes leads
T32375 1393-1397 RB denotes also
T32374 1381-1392 NN denotes necroptosis
T32373 1374-1380 IN denotes during
T32372 1370-1373 NN denotes Akt
T32371 1367-1369 IN denotes of
T32370 1356-1366 NN denotes Activation
T32369 1345-1354 NN denotes synthesis
T32368 1340-1344 NN denotes TNFα
T32367 1337-1339 TO denotes to
T32366 1331-1336 VB denotes leads
T32365 1320-1330 NN denotes activation
T32364 1316-1319 NN denotes JNK
T32363 1314-1315 -COMMA- denotes ,
T32362 1311-1314 NN denotes Akt
T32361 1306-1310 IN denotes from
T32360 1295-1305 NN denotes Downstream
T32359 1287-1293 NN denotes kinase
T32358 1282-1286 NN denotes RIP1
T32357 1278-1281 CC denotes and
T32356 1270-1277 NN denotes factors
T32355 1263-1269 NN denotes growth
T32354 1258-1262 DT denotes both
T32353 1253-1257 IN denotes from
T32352 1246-1252 NN denotes inputs
T32351 1237-1245 VB denotes requires
T32350 1225-1236 NN denotes necroptosis
T32349 1218-1224 IN denotes during
T32348 1211-1217 NN denotes Thr308
T32347 1208-1210 IN denotes at
T32346 1192-1207 NN denotes phosphorylation
T32345 1188-1191 NN denotes Akt
T32344 1181-1186 NN denotes cells
T32343 1176-1180 NN denotes L929
T32342 1164-1175 JJ denotes necroptotic
T32341 1161-1163 IN denotes in
T32340 1151-1160 NN denotes signaling
T32339 1141-1150 JJ denotes dependent
T32338 1137-1140 NN denotes JNK
T32337 1133-1136 CC denotes and
T32336 1129-1132 NN denotes Akt
T32335 1127-1128 -COMMA- denotes ,
T32334 1123-1127 NN denotes RIP1
T32333 1120-1122 IN denotes of
T32332 1114-1119 NN denotes Model
T19241 4582-4589 NN denotes effects
T19240 4571-4581 JJ denotes off-target
T19239 4561-4570 JJ denotes potantial
T19238 4558-4560 TO denotes to
T19237 4554-4557 JJ denotes due
T19236 4545-4553 NN denotes SP600125
T19235 4539-4544 VB denotes using
T19234 4534-4538 WRB denotes when
T19233 4526-4533 NN denotes caution
T19232 4522-4525 VB denotes use
T19231 4519-4521 TO denotes to
T19230 4514-4518 VB denotes need
T19229 4502-4513 NN denotes researchers
T19228 4500-4501 -COMMA- denotes ,
T19227 4492-4500 NN denotes addition
T19226 4489-4491 IN denotes In
T19225 4475-4487 RB denotes functionally
T19224 4463-4474 JJ denotes dispensable
T19223 4460-4462 CC denotes or
T19222 4458-4459 -RRB- denotes )
T19221 4457-4458 -RRB- denotes ]
T19220 4455-4457 CD denotes 44
T19219 4454-4455 -LRB- denotes [
T19218 4448-4453 VB denotes occur
T19217 4444-4447 MD denotes may
T19216 4438-4443 NN denotes Ser63
T19215 4433-4437 IN denotes than
T19214 4427-4432 JJ denotes other
T19213 4422-4426 NN denotes site
T19212 4420-4421 DT denotes a
T19211 4417-4419 IN denotes on
T19210 4411-4416 NN denotes c-Jun
T19209 4408-4410 IN denotes of
T19208 4392-4407 NN denotes phosphorylation
T19207 4387-4391 FW denotes e.g.
T19206 4386-4387 -LRB- denotes (
T19205 4376-4385 JJ denotes redundant
T19204 4369-4375 CC denotes either
T19203 4366-4368 VB denotes be
T19202 4362-4365 MD denotes may
T19201 4358-4361 CC denotes but
T19200 4356-4357 -COMMA- denotes ,
T19199 4346-4356 NN denotes activation
T19198 4338-4345 NN denotes pathway
T19197 4335-4337 IN denotes of
T19196 4328-4334 NN denotes marker
T19195 4321-4327 JJ denotes useful
T19194 4319-4320 DT denotes a
T19193 4316-4318 IN denotes as
T19192 4310-4315 VB denotes serve
T19191 4306-4309 MD denotes may
T19190 4297-4305 NN denotes activity
T19189 4293-4296 NN denotes JNK
T19188 4287-4292 IN denotes while
T19187 4285-4286 -COMMA- denotes ,
T19186 4274-4285 NN denotes necroptosis
T19185 4270-4273 IN denotes for
T19184 4261-4269 JJ denotes critical
T19183 4258-4260 VB denotes is
T19182 4252-4257 NN denotes c-Jun
T19181 4247-4251 IN denotes that
T19180 4236-4246 NN denotes conclusion
T19179 4226-4235 JJ denotes important
T19178 4222-4225 CC denotes but
T19177 4220-4221 -COMMA- denotes ,
T19176 4210-4220 JJ denotes unexpected
T19175 4207-4209 DT denotes an
T19174 4204-4206 TO denotes to
T19173 4201-4203 PRP denotes us
T19172 4197-4200 VB denotes led
T19171 4192-4196 NN denotes data
T19170 4188-4191 JJ denotes new
T19169 4182-4187 DT denotes These
T19168 4179-4180 -RRB- denotes )
T19167 4178-4179 NN denotes F
T19166 4177-4178 -COMMA- denotes ,
T19165 4175-4177 NN denotes 6E
T19164 4170-4174 NNP denotes Fig.
T19163 4169-4170 -LRB- denotes (
T19162 4154-4168 JJ denotes mTOR-dependent
T19161 4150-4153 CC denotes and
T19160 4146-4149 NN denotes Akt
T19159 4141-4145 CC denotes both
T19158 4137-4140 VB denotes was
T19157 4131-4136 WDT denotes which
T19156 4129-4130 -COMMA- denotes ,
T19155 4125-4129 NN denotes TNFα
T19154 4122-4124 CC denotes or
T19153 4113-4121 NN denotes zVAD.fmk
T19152 4108-4112 IN denotes with
T19151 4102-4107 NN denotes cells
T19150 4097-4101 NN denotes L929
T19149 4094-4096 IN denotes of
T19148 4084-4093 NN denotes treatment
T19147 4078-4083 IN denotes after
T19146 4072-4077 NN denotes c-Jun
T19145 4069-4071 IN denotes of
T19144 4063-4068 NN denotes level
T19143 4055-4062 NN denotes protein
T19142 4051-4054 DT denotes the
T19141 4048-4050 IN denotes in
T19140 4039-4047 NN denotes increase
T19139 4031-4038 JJ denotes overall
T19138 4028-4030 DT denotes an
T19137 4019-4027 VB denotes observed
T19136 4016-4018 PRP denotes we
T19135 4011-4015 IN denotes that
T19134 4006-4010 VB denotes note
T19133 4003-4005 TO denotes to
T19132 3993-4002 JJ denotes important
T19131 3988-3992 RB denotes also
T19130 3985-3987 VB denotes is
T19129 3982-3984 PRP denotes It
T19128 3977-3981 NNP denotes Akt.
T19127 3974-3976 IN denotes of
T19126 3963-3973 NN denotes activation
T19125 3955-3962 VB denotes delayed
T19124 3951-3954 DT denotes the
T19123 3948-3950 TO denotes to
T19122 3936-3947 VB denotes contributes
T19121 3931-3935 WDT denotes that
T19120 3926-3930 NN denotes loop
T19119 3917-3925 NN denotes feedback
T19118 3915-3916 DT denotes a
T19117 3908-3914 VB denotes create
T19116 3904-3907 MD denotes may
T19115 3902-3903 -COMMA- denotes ,
T19114 3897-3902 NN denotes c-Jun
T19113 3894-3896 IN denotes on
T19112 3884-3893 JJ denotes dependent
T19111 3882-3883 -COMMA- denotes ,
T19110 3872-3882 NN denotes production
T19109 3867-3871 NN denotes TNFα
T19108 3857-3866 JJ denotes autocrine
T19107 3855-3856 -COMMA- denotes ,
T19106 3851-3855 RB denotes Thus
T19105 3838-3849 NN denotes necroptosis
T19104 3835-3837 IN denotes of
T19103 3825-3834 NN denotes induction
T19102 3821-3824 DT denotes the
T19101 3815-3820 IN denotes after
T19100 3807-3814 VB denotes reduced
T19099 3803-3806 VB denotes was
T19098 3787-3802 NN denotes phosphorylation
T19097 3780-3786 NN denotes Thr308
T19096 3778-3779 -COMMA- denotes ,
T19095 3774-3778 NN denotes case
T19094 3769-3773 DT denotes this
T19093 3766-3768 IN denotes in
T19092 3764-3765 -COMMA- denotes ,
T19091 3757-3764 RB denotes Notably
T19090 3754-3755 -RRB- denotes )
T19089 3748-3754 NN denotes S10H–J
T19088 3743-3747 NNP denotes Fig.
T19087 3742-3743 -LRB- denotes (
T19086 3732-3741 NN denotes knockdown
T19085 3726-3731 NN denotes siRNA
T19084 3720-3725 NN denotes c-Jun
T19083 3714-3719 VB denotes using
T19082 3702-3713 NN denotes conclusions
T19081 3696-3701 DT denotes these
T19080 3686-3695 VB denotes confirmed
T19079 3683-3685 PRP denotes we
T19078 3679-3682 CC denotes and
T19077 3677-3678 -RRB- denotes ]
T19076 3675-3677 CD denotes 15
T19075 3674-3675 -LRB- denotes [
T19074 3672-3673 -COMMA- denotes ,
T19073 3671-3672 -RRB- denotes ]
T19072 3669-3671 CD denotes 14
T19071 3668-3669 -LRB- denotes [
T19070 3666-3667 -COMMA- denotes ,
T19069 3665-3666 -RRB- denotes ]
T19068 3663-3665 CD denotes 13
T19067 3662-3663 -LRB- denotes [
T19066 3652-3661 NN denotes synthesis
T19065 3647-3651 NN denotes TNFα
T19064 3637-3646 JJ denotes autocrine
T19063 3633-3636 CC denotes and
T19062 3621-3632 NN denotes necroptosis
T19061 3618-3620 IN denotes in
T19060 3612-3617 NN denotes c-Jun
T19059 3608-3611 IN denotes for
T19058 3603-3607 NN denotes role
T19057 3594-3602 JJ denotes critical
T19056 3592-3593 DT denotes a
T19055 3582-3591 VB denotes suggested
T19054 3577-3581 RB denotes also
T19053 3569-3576 NN denotes reports
T19052 3560-3568 JJ denotes Previous
T19051 3548-3558 NN denotes inhibition
T19050 3544-3547 NN denotes JNK
T19049 3539-3543 IN denotes than
T19048 3532-3538 RB denotes rather
T19047 3530-3531 -COMMA- denotes ,
T19046 3522-3530 NN denotes molecule
T19045 3517-3521 DT denotes this
T19044 3514-3516 IN denotes of
T19043 3506-3513 NN denotes effects
T19042 3495-3505 JJ denotes off-target
T19041 3487-3494 VB denotes reflect
T19040 3481-3486 MD denotes could
T19039 3479-3480 -RRB- denotes )
T19038 3478-3479 CD denotes 2
T19037 3473-3477 NN denotes Fig.
T19036 3472-3473 -LRB- denotes (
T19035 3461-3471 NN denotes protection
T19034 3452-3460 NN denotes SP600125
T19033 3447-3451 IN denotes with
T19032 3442-3446 NN denotes data
T19031 3434-3441 JJ denotes earlier
T19030 3429-3433 IN denotes that
T19029 3418-3428 VB denotes suggesting
T19028 3416-3417 -COMMA- denotes ,
T19027 3415-3416 -RRB- denotes )
T19025 3413-3414 -COMMA- denotes ,
T19024 3412-3413 NNP denotes F
T19023 3411-3412 -COMMA- denotes ,
T19022 3410-3411 NNP denotes D
T19021 3409-3410 -COMMA- denotes ,
T19020 3405-3409 NN denotes S10C
T19019 3400-3404 NNP denotes Fig.
T19018 3399-3400 -LRB- denotes (
T19017 3393-3398 NN denotes death
T19016 3388-3392 NN denotes cell
T19015 3385-3387 CC denotes or
T19014 3374-3384 NN denotes production
T19013 3369-3373 NN denotes TNFα
T19012 3366-3368 IN denotes in
T19011 3356-3365 NN denotes reduction
T19010 3354-3355 DT denotes a
T19009 3351-3353 TO denotes to
T19008 3346-3350 VB denotes lead
T19007 3344-3345 -COMMA- denotes ,
T19006 3337-3344 RB denotes however
T19005 3335-3336 -COMMA- denotes ,
T19004 3332-3335 RB denotes not
T19003 3328-3331 VB denotes did
T19002 3325-3327 PRP denotes It
T19001 3318-3323 NN denotes model
T19000 3314-3317 PRP-DOLLAR- denotes our
T18999 3309-3313 IN denotes with
T18998 3300-3308 VB denotes agreeing
T18997 3298-3299 -COMMA- denotes ,
T18996 3297-3298 -RRB- denotes )
T18995 3296-3297 NN denotes E
T18994 3295-3296 -COMMA- denotes ,
T18993 3291-3295 NN denotes S10B
T18992 3286-3290 NNP denotes Fig.
T18991 3285-3286 -LRB- denotes (
T18990 3279-3284 NN denotes Ser63
T18989 3276-3278 IN denotes at
T18988 3270-3275 NN denotes c-Jun
T18987 3267-3269 IN denotes of
T18986 3251-3266 NN denotes phosphorylation
T18985 3247-3250 DT denotes the
T18984 3236-3246 VB denotes inhibiting
T18983 3230-3235 IN denotes while
T18982 3223-3229 NN denotes Thr308
T18981 3220-3222 IN denotes on
T18980 3216-3219 NN denotes Akt
T18979 3213-3215 IN denotes of
T18978 3197-3212 NN denotes phosphorylation
T18977 3189-3196 VB denotes allowed
T18976 3182-3188 NN denotes JNK1/2
T18975 3179-3181 IN denotes of
T18974 3169-3178 NN denotes knockdown
T18973 3166-3168 CC denotes or
T18972 3155-3165 NN denotes inhibition
T18971 3146-3154 JJ denotes specific
T18970 3144-3145 -COMMA- denotes ,
T18969 3136-3144 VB denotes expected
T18968 3133-3135 IN denotes As
T18967 3130-3131 -RRB- denotes )
T18966 3124-3130 NN denotes S10B–G
T18965 3119-3123 NN denotes Fig.
T18964 3118-3119 -LRB- denotes (
T18963 3113-3117 NN denotes JNK2
T18962 3109-3112 CC denotes and
T18961 3104-3108 NN denotes JNK1
T18960 3096-3103 IN denotes against
T18959 3089-3095 NN denotes siRNAs
T18958 3085-3088 CC denotes and
T18957 3083-3084 -COMMA- denotes ,
T18956 3082-3083 -RRB- denotes ]
T18955 3080-3082 CD denotes 43
T18954 3079-3080 -LRB- denotes [
T18953 3074-3078 CD denotes VIII
T18952 3064-3073 NN denotes inhibitor
T18951 3060-3063 NN denotes JNK
T18950 3058-3059 -COMMA- denotes ,
T18949 3049-3058 NN denotes inhibitor
T18948 3045-3048 NN denotes JNK
T18947 3036-3044 JJ denotes specific
T18946 3031-3035 RB denotes more
T18945 3029-3030 DT denotes a
T18944 3026-3028 TO denotes to
T18943 3017-3025 VB denotes switched
T18942 3014-3016 PRP denotes we
T18941 3012-3013 -COMMA- denotes ,
T18940 3009-3012 NN denotes JNK
T18939 3006-3008 IN denotes of
T18938 3001-3005 NN denotes role
T18937 2997-3000 DT denotes the
T18936 2989-2996 VB denotes examine
T18935 2986-2988 TO denotes to
T18934 2984-2985 -COMMA- denotes ,
T18933 2975-2984 RB denotes Therefore
T18932 2967-2973 NN denotes system
T18931 2962-2966 DT denotes this
T18930 2959-2961 IN denotes in
T18929 2950-2958 NN denotes SP600125
T18928 2947-2949 IN denotes of
T18927 2943-2946 NN denotes use
T18926 2939-2942 DT denotes the
T18925 2928-2938 VB denotes precluding
T18924 2926-2927 -COMMA- denotes ,
T18923 2920-2926 NN denotes levels
T18922 2904-2919 NN denotes phosphorylation
T18921 2900-2903 NN denotes Akt
T18920 2894-2899 JJ denotes basal
T18919 2886-2893 VB denotes inhibit
T18918 2880-2885 MD denotes could
T18917 2872-2879 NN denotes effects
T18916 2861-2871 JJ denotes off-target
T18915 2855-2860 DT denotes these
T18914 2852-2854 IN denotes of
T18913 2847-2851 DT denotes Both
T18912 2844-2845 -RRB- denotes ]
T18911 2842-2844 CD denotes 42
T18910 2841-2842 -LRB- denotes [
T18909 2836-2840 NN denotes PDK1
T18908 2832-2835 CC denotes and
T18907 2830-2831 -RRB- denotes ]
T18906 2828-2830 CD denotes 41
T18905 2827-2828 -LRB- denotes [
T18904 2822-2826 NN denotes PI3K
T18903 2819-2821 IN denotes of
T18902 2811-2818 NN denotes subunit
T18901 2805-2810 NN denotes p110δ
T18900 2801-2804 DT denotes the
T18899 2793-2800 VB denotes inhibit
T18898 2789-2792 MD denotes may
T18897 2784-2788 WDT denotes that
T18896 2774-2783 NN denotes inhibitor
T18895 2761-2773 JJ denotes non-specific
T18894 2752-2760 RB denotes somewhat
T18893 2750-2751 DT denotes a
T18892 2747-2749 VB denotes is
T18891 2738-2746 NN denotes SP600125
T18890 2733-2737 IN denotes that
T18889 2723-2732 VB denotes published
T18888 2718-2722 VB denotes been
T18887 2714-2717 VB denotes has
T18886 2711-2713 PRP denotes It
T18885 2708-2709 -RRB- denotes )
T18884 2704-2708 NN denotes S10B
T18883 2699-2703 NN denotes Fig.
T18882 2698-2699 -LRB- denotes (
T18881 2691-2697 NN denotes Thr308
T18880 2687-2690 CC denotes and
T18879 2680-2686 NN denotes Ser473
T18878 2675-2679 CC denotes both
T18877 2672-2674 IN denotes at
T18876 2668-2671 NN denotes Akt
T18875 2665-2667 IN denotes of
T18874 2658-2664 NN denotes levels
T18873 2642-2657 NN denotes phosphorylation
T18872 2627-2641 JJ denotes post-treatment
T18871 2623-2626 CC denotes and
T18870 2617-2622 JJ denotes basal
T18869 2612-2616 CC denotes both
T18868 2602-2611 VB denotes inhibited
T18867 2600-2601 -COMMA- denotes ,
T18866 2599-2600 -RRB- denotes )
T18865 2595-2599 NN denotes S10A
T18864 2591-2594 NN denotes S2A
T18863 2589-2590 NN denotes B
T18862 2588-2589 -COMMA- denotes ,
T18861 2586-2588 NN denotes 2A
T18860 2581-2585 NNP denotes Fig.
T18859 2580-2581 -LRB- denotes (
T18858 2569-2579 NN denotes production
T18857 2564-2568 NN denotes TNFα
T18856 2554-2563 VB denotes inhibited
T18855 2550-2553 CC denotes and
T18854 2544-2549 NN denotes death
T18853 2539-2543 IN denotes from
T18852 2533-2538 NN denotes cells
T18851 2528-2532 NN denotes L929
T18850 2518-2527 VB denotes protected
T18849 2512-2517 WDT denotes which
T18848 2510-2511 -COMMA- denotes ,
T18847 2502-2510 NN denotes SP600125
T18846 2497-2501 IN denotes that
T18845 2491-2496 VB denotes found
T18844 2488-2490 PRP denotes we
T18843 2486-2487 -COMMA- denotes ,
T18842 2479-2486 RB denotes However
T18841 2474-2477 NN denotes JNK
T18840 2472-2473 -COMMA- denotes ,
T18839 2465-2472 NN denotes pathway
T18838 2461-2464 DT denotes the
T18837 2458-2460 IN denotes in
T18836 2451-2457 NN denotes kinase
T18835 2440-2450 JJ denotes downstream
T18834 2438-2439 DT denotes a
T18833 2435-2437 IN denotes of
T18832 2424-2434 NN denotes inhibition
T18831 2418-2423 IN denotes after
T18830 2402-2417 NN denotes phosphorylation
T18829 2398-2401 NN denotes Akt
T18828 2389-2397 VB denotes examined
T18827 2386-2388 PRP denotes we
T18826 2384-2385 -COMMA- denotes ,
T18825 2379-2384 NN denotes model
T18824 2375-2378 PRP-DOLLAR- denotes our
T18823 2370-2374 VB denotes test
T18822 2362-2369 RB denotes further
T18821 2359-2361 TO denotes to
T18820 2353-2358 NN denotes order
T18819 2350-2352 IN denotes In
T18818 2347-2348 -RRB- denotes ]
T18817 2345-2347 CD denotes 15
T18816 2344-2345 -LRB- denotes [
T18815 2338-2343 NN denotes cells
T18814 2333-2337 NN denotes L929
T18813 2330-2332 IN denotes in
T18812 2318-2329 NN denotes necroptosis
T18811 2315-2317 IN denotes in
T18810 2309-2314 NN denotes event
T18712 1696-1700 NN denotes form
T18711 1691-1695 DT denotes this
T18710 1687-1690 IN denotes for
T18709 1673-1686 JJ denotes indispensable
T18708 1670-1672 VB denotes is
T18707 1666-1669 NN denotes Akt
T18706 1663-1665 IN denotes of
T18705 1652-1662 NN denotes activation
T18704 1640-1651 JJ denotes necroptotic
T18703 1635-1639 IN denotes that
T18702 1628-1634 VB denotes showed
T18701 1625-1627 PRP denotes we
T18700 1623-1624 -COMMA- denotes ,
T18699 1616-1623 NN denotes mutants
T18698 1612-1615 NN denotes Akt
T18697 1609-1611 IN denotes of
T18696 1598-1608 NN denotes expression
T18695 1594-1597 DT denotes the
T18694 1590-1593 CC denotes and
T18693 1588-1589 -COMMA- denotes ,
T18692 1580-1588 NN denotes isoforms
T18691 1576-1579 NN denotes Akt
T18690 1573-1575 IN denotes of
T18689 1563-1572 NN denotes knockdown
T18688 1561-1562 -COMMA- denotes ,
T18687 1551-1561 NN denotes inhibitors
T18686 1547-1550 NN denotes Akt
T18685 1541-1546 VB denotes Using
T18684 1062-1068 NN denotes signal
T18683 1050-1061 JJ denotes necroptotic
T18682 1046-1049 DT denotes the
T18681 1043-1045 IN denotes of
T18680 1031-1042 NN denotes propagation
T18679 1027-1030 DT denotes the
T18678 1023-1026 IN denotes for
T18677 1013-1022 JJ denotes essential
T18676 1010-1012 VB denotes is
T18675 1006-1009 CC denotes and
T18674 995-1005 NN denotes inhibition
T18673 987-994 NN denotes caspase
T18672 984-986 TO denotes to
T18671 975-983 NN denotes response
T18670 972-974 IN denotes in
T18669 968-971 NN denotes Akt
T18668 965-967 IN denotes of
T18667 949-964 NN denotes phosphorylation
T18666 942-948 NN denotes Thr308
T18665 938-941 IN denotes for
T18664 929-937 VB denotes required
T18663 926-928 VB denotes is
T18662 920-925 NN denotes input
T18661 903-919 JJ denotes kinase-dependent
T18660 898-902 NN denotes RIP1
T18659 896-897 -COMMA- denotes ,
T18658 890-896 JJ denotes second
T18657 888-889 DT denotes A
T18656 875-886 NN denotes necroptosis
T18655 872-874 IN denotes of
T18654 862-871 NN denotes induction
T18653 858-861 DT denotes the
T18652 854-857 IN denotes for
T18651 843-853 JJ denotes sufficient
T18650 839-842 RB denotes not
T18649 836-838 VB denotes is
T18648 830-835 RB denotes alone
T18647 822-829 NN denotes Myr-Akt
T18646 819-821 IN denotes of
T18645 808-818 NN denotes expression
T18644 806-807 -COMMA- denotes ,
T18643 802-806 NN denotes time
T18642 797-801 JJ denotes same
T18641 793-796 DT denotes the
T18640 790-792 IN denotes At
T18639 781-788 NN denotes factors
T18638 774-780 NN denotes growth
T18637 770-773 IN denotes for
T18636 758-769 NN denotes requirement
T18635 754-757 DT denotes the
T18634 744-753 VB denotes overcomes
T18633 742-743 -COMMA- denotes ,
T18632 735-742 NN denotes Myr-Akt
T18631 733-734 -COMMA- denotes ,
T18630 724-733 NN denotes construct
T18629 720-723 NN denotes Akt
T18628 702-719 JJ denotes membrane-targeted
T18627 687-701 RB denotes constitutively
T18626 685-686 DT denotes a
T18625 682-684 IN denotes of
T18624 671-681 NNP denotes Expression
T18623 666-670 NNP denotes Akt.
T18622 663-665 IN denotes of
T18621 650-662 NN denotes localization
T18620 641-649 NN denotes membrane
T18619 634-640 NN denotes plasma
T18618 630-633 DT denotes the
T18617 627-629 TO denotes to
T18616 621-626 VB denotes leads
T18615 619-620 -COMMA- denotes ,
T18614 612-619 NN denotes factors
T18613 605-611 NN denotes growth
T18612 602-604 IN denotes by
T18611 594-601 VB denotes induced
T18610 591-593 VB denotes is
T18609 585-590 WDT denotes which
T18608 583-584 -COMMA- denotes ,
T18607 578-583 NN denotes input
T18606 572-577 JJ denotes first
T18605 568-571 DT denotes The
T18604 559-566 NN denotes signals
T18603 550-558 JJ denotes distinct
T18602 546-549 CD denotes two
T18601 537-545 VB denotes requires
T18600 533-536 NN denotes Akt
T18599 530-532 IN denotes of
T18598 514-529 NN denotes phosphorylation
T18597 491-513 JJ denotes necroptosis-associated
T18596 489-490 -COMMA- denotes ,
T18595 488-489 -RRB- denotes )
T18594 487-488 CD denotes 9
T18593 482-486 NN denotes Fig.
T18592 481-482 -LRB- denotes (
T18591 475-480 NN denotes model
T18590 471-474 PRP-DOLLAR- denotes our
T18589 468-470 TO denotes to
T18588 458-467 VB denotes According
T18587 450-456 NN denotes Ser473
T18586 446-449 RB denotes not
T18585 442-445 CC denotes but
T18584 440-441 -COMMA- denotes ,
T18583 434-440 NN denotes Thr308
T18582 431-433 IN denotes on
T18581 415-430 NN denotes phosphorylation
T18580 411-414 PRP-DOLLAR- denotes its
T18579 408-410 IN denotes in
T18578 399-407 NN denotes increase
T18577 389-398 JJ denotes selective
T18576 387-388 DT denotes a
T18575 384-386 TO denotes to
T18574 378-383 VB denotes leads
T18573 372-377 WDT denotes which
T18572 370-371 -COMMA- denotes ,
T18571 364-370 NN denotes kinase
T18570 359-363 NN denotes RIP1
T18569 354-358 IN denotes from
T18568 343-353 RB denotes downstream
T18567 333-342 VB denotes signaling
T18566 330-332 IN denotes in
T18565 322-329 VB denotes engaged
T18564 309-321 RB denotes specifically
T18563 306-308 VB denotes is
T18562 299-305 NN denotes kinase
T18561 295-298 NN denotes Akt
T18560 290-294 IN denotes that
T18559 282-289 VB denotes suggest
T18558 274-281 NN denotes results
T18557 270-273 PRP-DOLLAR- denotes our
T18556 268-269 -COMMA- denotes ,
T18555 258-268 RB denotes Altogether
T18554 248-256 NN denotes zVAD.fmk
T18553 238-247 NN denotes inhibitor
T18552 226-237 NN denotes pan-caspase
T18551 222-225 DT denotes the
T18550 217-221 IN denotes with
T18549 209-216 VB denotes treated
T18548 204-208 WRB denotes when
T18547 192-203 NN denotes necroptosis
T18546 189-191 IN denotes by
T18545 185-188 VB denotes die
T18544 180-184 WDT denotes that
T18543 174-179 NN denotes cells
T18542 169-173 NN denotes L929
T18541 156-168 NN denotes fibrosarcoma
T18540 150-155 NN denotes mouse
T18539 144-149 VB denotes using
T18538 135-143 NN denotes pathways
T18537 125-134 NN denotes signaling
T18536 108-124 JJ denotes kinase-dependent
T18535 103-107 NN denotes RIP1
T18534 90-102 VB denotes investigated
T18533 87-89 PRP denotes we
T18532 81-86 NN denotes study
T18531 76-80 DT denotes this
T18530 73-75 IN denotes In
T18529 67-72 NN denotes Cells
T18528 62-66 NN denotes L929
T18527 50-61 JJ denotes Necroptotic
T18526 47-49 IN denotes in
T18525 37-46 NN denotes Signaling
T18524 27-36 JJ denotes Dependent
T18523 23-26 NN denotes JNK
T19026 3414-3415 NN denotes G
T18522 19-22 CC denotes and
T18521 15-18 NN denotes Akt
T18520 13-14 -COMMA- denotes ,
T18519 9-13 NN denotes RIP1
T18518 6-8 IN denotes of
T18517 0-5 NN denotes Model
T18809 2300-2308 JJ denotes critical
T18808 2298-2299 DT denotes a
T18807 2296-2297 -COMMA- denotes ,
T18806 2287-2296 NN denotes synthesis
T18805 2282-2286 NN denotes TNFα
T18804 2272-2281 JJ denotes autocrine
T18803 2268-2271 CC denotes and
T18802 2257-2267 NN denotes activation
T18801 2253-2256 NN denotes JNK
T18800 2251-2252 -COMMA- denotes ,
T18799 2245-2251 RB denotes namely
T18798 2243-2244 -COMMA- denotes ,
T18797 2238-2243 NN denotes cells
T18796 2233-2237 NN denotes L929
T18795 2221-2232 JJ denotes necroptotic
T18794 2218-2220 IN denotes in
T18793 2211-2217 NN denotes events
T18792 2201-2210 NN denotes execution
T18791 2197-2200 CC denotes and
T18790 2187-2196 NN denotes signaling
T18789 2176-2186 JJ denotes downstream
T18788 2170-2175 VB denotes known
T18787 2167-2169 TO denotes to
T18786 2160-2166 NN denotes kinase
T18785 2155-2159 NN denotes RIP1
T18784 2144-2154 VB denotes connecting
T18783 2139-2143 NN denotes link
T18782 2131-2138 JJ denotes pivotal
T18781 2129-2130 DT denotes a
T18780 2120-2128 VB denotes provides
T18779 2109-2119 NN denotes activation
T18778 2105-2108 NN denotes Akt
T18777 2100-2104 IN denotes that
T18776 2090-2099 VB denotes suggested
T18775 2085-2089 NN denotes data
T18774 2081-2084 PRP-DOLLAR- denotes our
T18773 2079-2080 -COMMA- denotes ,
T18772 2073-2079 RB denotes Second
T18771 2066-2071 NN denotes death
T18770 2061-2065 NN denotes cell
T18769 2058-2060 TO denotes to
T18768 2046-2057 VB denotes contributes
T18767 2044-2045 -COMMA- denotes ,
T18766 2040-2044 NN denotes turn
T18765 2037-2039 IN denotes in
T18764 2035-2036 -COMMA- denotes ,
T18763 2030-2035 WDT denotes which
T18762 2028-2029 -COMMA- denotes ,
T18761 2021-2028 NN denotes pathway
T18760 2014-2020 NN denotes mTORC1
T18759 2010-2013 DT denotes the
T18758 2007-2009 IN denotes as
T18757 2002-2006 JJ denotes such
T18756 1993-2001 NN denotes pathways
T18755 1984-1992 NN denotes effector
T18754 1980-1983 NN denotes Akt
T18753 1976-1979 CC denotes and
T18752 1965-1975 NN denotes substrates
T18751 1959-1964 JJ denotes known
T18750 1956-1958 IN denotes of
T18749 1949-1955 NN denotes number
T18748 1947-1948 DT denotes a
T18747 1939-1946 IN denotes towards
T18746 1930-1938 NN denotes activity
T18745 1926-1929 PRP-DOLLAR- denotes its
T18744 1917-1925 VB denotes increase
T18743 1914-1916 TO denotes to
T18742 1903-1913 JJ denotes sufficient
T18741 1900-1902 VB denotes is
T18740 1896-1899 NN denotes Akt
T18739 1893-1895 IN denotes of
T18738 1886-1892 NN denotes Thr308
T18737 1883-1885 IN denotes of
T18736 1867-1882 NN denotes phosphorylation
T18735 1855-1866 JJ denotes necroptotic
T18734 1845-1854 JJ denotes selective
T18733 1840-1844 IN denotes that
T18732 1827-1839 VB denotes demonstrated
T18731 1824-1826 PRP denotes we
T18730 1822-1823 -COMMA- denotes ,
T18729 1817-1822 RB denotes First
T18728 1804-1815 NN denotes necroptosis
T18727 1801-1803 TO denotes to
T18726 1790-1800 VB denotes contribute
T18725 1785-1789 WDT denotes that
T18724 1776-1784 NN denotes pathways
T18723 1762-1775 JJ denotes Akt-dependent
T18722 1751-1761 JJ denotes downstream
T18721 1738-1750 VB denotes investigated
T18720 1733-1737 RB denotes also
T18719 1730-1732 PRP denotes We
T18718 1723-1728 NN denotes cells
T18717 1718-1722 NN denotes L929
T18716 1715-1717 IN denotes in
T18715 1709-1714 NN denotes death
T18714 1704-1708 NN denotes cell
T18713 1701-1703 IN denotes of
R12164 T18517 T18518 arg1Of Model,of
R12165 T18517 T18526 arg1Of Model,in
R12166 T18519 T18520 arg1Of RIP1,","
R12167 T18520 T18522 arg1Of ",",and
R12168 T18521 T18520 arg2Of Akt,","
R12169 T18522 T18518 arg2Of and,of
R12170 T18524 T18523 arg1Of Dependent,JNK
R12171 T18525 T18522 arg2Of Signaling,and
R12172 T18525 T18524 arg1Of Signaling,Dependent
R12173 T18529 T18526 arg2Of Cells,in
R12174 T18529 T18527 arg1Of Cells,Necroptotic
R12175 T18529 T18528 arg1Of Cells,L929
R12176 T18532 T18530 arg2Of study,In
R12177 T18532 T18531 arg1Of study,this
R12178 T18533 T18534 arg1Of we,investigated
R12179 T18534 T18530 arg1Of investigated,In
R12180 T18538 T18534 arg2Of pathways,investigated
R12181 T18538 T18535 arg1Of pathways,RIP1
R12182 T18538 T18536 arg1Of pathways,kinase-dependent
R12183 T18538 T18537 arg1Of pathways,signaling
R12184 T18538 T18539 arg1Of pathways,using
R12185 T18543 T18539 arg2Of cells,using
R12186 T18543 T18540 arg1Of cells,mouse
R12187 T18543 T18541 arg1Of cells,fibrosarcoma
R12188 T18543 T18542 arg1Of cells,L929
R12189 T18543 T18544 arg1Of cells,that
R12190 T18543 T18545 arg1Of cells,die
R12191 T18545 T18546 arg1Of die,by
R12192 T18545 T18548 arg1Of die,when
R12193 T18547 T18546 arg2Of necroptosis,by
R12194 T18549 T18548 arg2Of treated,when
R12195 T18549 T18550 arg1Of treated,with
R12196 T18554 T18550 arg2Of zVAD.fmk,with
R12197 T18554 T18551 arg1Of zVAD.fmk,the
R12198 T18554 T18552 arg1Of zVAD.fmk,pan-caspase
R12199 T18554 T18553 arg1Of zVAD.fmk,inhibitor
R12200 T18558 T18557 arg1Of results,our
R12201 T18558 T18559 arg1Of results,suggest
R12202 T18559 T18555 arg1Of suggest,Altogether
R12203 T18559 T18556 arg1Of suggest,","
R12204 T18562 T18561 arg1Of kinase,Akt
R12205 T18562 T18563 arg1Of kinase,is
R12206 T18562 T18565 arg2Of kinase,engaged
R12207 T18565 T18559 arg2Of engaged,suggest
R12208 T18565 T18560 arg1Of engaged,that
R12209 T18565 T18563 arg2Of engaged,is
R12210 T18565 T18564 arg1Of engaged,specifically
R12211 T18565 T18566 arg1Of engaged,in
R12212 T18567 T18566 arg2Of signaling,in
R12213 T18567 T18568 arg1Of signaling,downstream
R12214 T18567 T18569 arg1Of signaling,from
R12215 T18571 T18569 arg2Of kinase,from
R12216 T18571 T18570 arg1Of kinase,RIP1
R12217 T18571 T18572 arg1Of kinase,","
R12218 T18571 T18573 arg1Of kinase,which
R12219 T18571 T18574 arg1Of kinase,leads
R12220 T18574 T18575 arg1Of leads,to
R12221 T18578 T18575 arg2Of increase,to
R12222 T18578 T18576 arg1Of increase,a
R12223 T18578 T18577 arg1Of increase,selective
R12224 T18578 T18579 arg1Of increase,in
R12225 T18581 T18582 arg1Of phosphorylation,on
R12226 T18581 T18585 arg1Of phosphorylation,but
R12227 T18583 T18582 arg2Of Thr308,on
R12228 T18585 T18579 arg2Of but,in
R12229 T18585 T18580 arg1Of but,its
R12230 T18585 T18584 arg1Of but,","
R12231 T18585 T18586 arg1Of but,not
R12232 T18587 T18585 arg2Of Ser473,but
R12233 T18589 T18588 arg2Of to,According
R12234 T18591 T18589 arg2Of model,to
R12235 T18591 T18590 arg1Of model,our
R12236 T18591 T18592 arg1Of model,(
R12237 T18593 T18592 arg2Of Fig.,(
R12238 T18593 T18594 arg1Of Fig.,9
R12239 T18595 T18592 arg3Of ),(
R12240 T18598 T18597 arg1Of phosphorylation,necroptosis-associated
R12241 T18598 T18599 arg1Of phosphorylation,of
R12242 T18598 T18601 arg1Of phosphorylation,requires
R12243 T18600 T18599 arg2Of Akt,of
R12244 T18601 T18588 arg1Of requires,According
R12245 T18601 T18596 arg1Of requires,","
R12246 T18604 T18601 arg2Of signals,requires
R12247 T18604 T18602 arg1Of signals,two
R12248 T18604 T18603 arg1Of signals,distinct
R12249 T18607 T18605 arg1Of input,The
R12250 T18607 T18606 arg1Of input,first
R12251 T18607 T18608 arg1Of input,","
R12252 T18607 T18609 arg1Of input,which
R12253 T18607 T18610 arg1Of input,is
R12254 T18607 T18611 arg2Of input,induced
R12255 T18607 T18616 arg1Of input,leads
R12256 T18607 T18631 arg1Of input,","
R12257 T18607 T18634 arg1Of input,overcomes
R12258 T18611 T18610 arg2Of induced,is
R12259 T18611 T18615 arg1Of induced,","
R12260 T18614 T18611 arg1Of factors,induced
R12261 T18614 T18612 arg2Of factors,by
R12262 T18614 T18613 arg1Of factors,growth
R12263 T18616 T18615 arg2Of leads,","
R12264 T18616 T18617 arg1Of leads,to
R12265 T18621 T18617 arg2Of localization,to
R12266 T18621 T18618 arg1Of localization,the
R12267 T18621 T18619 arg1Of localization,plasma
R12268 T18621 T18620 arg1Of localization,membrane
R12269 T18621 T18622 arg1Of localization,of
R12270 T18624 T18622 arg2Of Expression,of
R12271 T18624 T18623 arg1Of Expression,Akt.
R12272 T18624 T18625 arg1Of Expression,of
R12273 T18628 T18627 arg1Of membrane-targeted,constitutively
R12274 T18630 T18625 arg2Of construct,of
R12275 T18630 T18626 arg1Of construct,a
R12276 T18630 T18628 arg1Of construct,membrane-targeted
R12277 T18630 T18629 arg1Of construct,Akt
R12278 T18632 T18631 arg2Of Myr-Akt,","
R12279 T18634 T18633 arg1Of overcomes,","
R12280 T18636 T18634 arg2Of requirement,overcomes
R12281 T18636 T18635 arg1Of requirement,the
R12282 T18636 T18637 arg1Of requirement,for
R12283 T18639 T18637 arg2Of factors,for
R12284 T18639 T18638 arg1Of factors,growth
R12285 T18643 T18640 arg2Of time,At
R12286 T18643 T18641 arg1Of time,the
R12287 T18643 T18642 arg1Of time,same
R12288 T18645 T18646 arg1Of expression,of
R12289 T18645 T18649 arg1Of expression,is
R12290 T18645 T18651 arg1Of expression,sufficient
R12291 T18647 T18646 arg2Of Myr-Akt,of
R12292 T18647 T18648 arg1Of Myr-Akt,alone
R12293 T18649 T18640 arg1Of is,At
R12294 T18649 T18644 arg1Of is,","
R12295 T18649 T18650 arg1Of is,not
R12296 T18651 T18649 arg2Of sufficient,is
R12297 T18651 T18652 arg1Of sufficient,for
R12298 T18654 T18652 arg2Of induction,for
R12299 T18654 T18653 arg1Of induction,the
R12300 T18654 T18655 arg1Of induction,of
R12301 T18656 T18655 arg2Of necroptosis,of
R12302 T18658 T18659 arg1Of second,","
R12303 T18661 T18659 arg2Of kinase-dependent,","
R12304 T18661 T18660 arg1Of kinase-dependent,RIP1
R12305 T18662 T18657 arg1Of input,A
R12306 T18662 T18658 arg1Of input,second
R12307 T18662 T18661 arg1Of input,kinase-dependent
R12308 T18662 T18663 arg1Of input,is
R12309 T18662 T18664 arg2Of input,required
R12310 T18662 T18676 arg1Of input,is
R12311 T18662 T18677 arg1Of input,essential
R12312 T18664 T18663 arg2Of required,is
R12313 T18664 T18665 arg1Of required,for
R12314 T18664 T18670 arg1Of required,in
R12315 T18664 T18675 arg1Of required,and
R12316 T18667 T18665 arg2Of phosphorylation,for
R12317 T18667 T18666 arg1Of phosphorylation,Thr308
R12318 T18667 T18668 arg1Of phosphorylation,of
R12319 T18669 T18668 arg2Of Akt,of
R12320 T18670 T18672 arg1Of in,to
R12321 T18671 T18670 arg2Of response,in
R12322 T18674 T18670 arg3Of inhibition,in
R12323 T18674 T18673 arg1Of inhibition,caspase
R12324 T18676 T18675 arg2Of is,and
R12325 T18677 T18676 arg2Of essential,is
R12326 T18677 T18678 arg1Of essential,for
R12327 T18680 T18678 arg2Of propagation,for
R12328 T18680 T18679 arg1Of propagation,the
R12329 T18680 T18681 arg1Of propagation,of
R12330 T18684 T18681 arg2Of signal,of
R12331 T18684 T18682 arg1Of signal,the
R12332 T18684 T18683 arg1Of signal,necroptotic
R12333 T18687 T18686 arg1Of inhibitors,Akt
R12334 T18687 T18688 arg1Of inhibitors,","
R12335 T18687 T18694 arg1Of inhibitors,and
R12336 T18689 T18688 arg2Of knockdown,","
R12337 T18689 T18690 arg1Of knockdown,of
R12338 T18692 T18690 arg2Of isoforms,of
R12339 T18692 T18691 arg1Of isoforms,Akt
R12340 T18694 T18685 arg2Of and,Using
R12341 T18694 T18693 arg1Of and,","
R12342 T18696 T18694 arg2Of expression,and
R12343 T18696 T18695 arg1Of expression,the
R12344 T18696 T18697 arg1Of expression,of
R12345 T18699 T18697 arg2Of mutants,of
R12346 T18699 T18698 arg1Of mutants,Akt
R12347 T18701 T18685 arg1Of we,Using
R12348 T18701 T18702 arg1Of we,showed
R12349 T18702 T18685 modOf showed,Using
R12350 T18702 T18700 arg1Of showed,","
R12351 T18705 T18704 arg1Of activation,necroptotic
R12352 T18705 T18706 arg1Of activation,of
R12353 T18705 T18708 arg1Of activation,is
R12354 T18705 T18709 arg1Of activation,indispensable
R12355 T18707 T18706 arg2Of Akt,of
R12356 T18708 T18702 arg2Of is,showed
R12357 T18708 T18703 arg1Of is,that
R12358 T18709 T18708 arg2Of indispensable,is
R12359 T18709 T18710 arg1Of indispensable,for
R12360 T18712 T18710 arg2Of form,for
R12361 T18712 T18711 arg1Of form,this
R12362 T18712 T18713 arg1Of form,of
R12363 T18715 T18713 arg2Of death,of
R12364 T18715 T18714 arg1Of death,cell
R12365 T18715 T18716 arg1Of death,in
R12366 T18718 T18716 arg2Of cells,in
R12367 T18718 T18717 arg1Of cells,L929
R12368 T18719 T18721 arg1Of We,investigated
R12369 T18721 T18720 arg1Of investigated,also
R12370 T18724 T18721 arg2Of pathways,investigated
R12371 T18724 T18722 arg1Of pathways,downstream
R12372 T18724 T18723 arg1Of pathways,Akt-dependent
R12373 T18724 T18725 arg1Of pathways,that
R12374 T18724 T18726 arg1Of pathways,contribute
R12375 T18726 T18727 arg1Of contribute,to
R12376 T18728 T18727 arg2Of necroptosis,to
R12377 T18731 T18732 arg1Of we,demonstrated
R12378 T18732 T18729 arg1Of demonstrated,First
R12379 T18732 T18730 arg1Of demonstrated,","
R12380 T18736 T18734 arg1Of phosphorylation,selective
R12381 T18736 T18735 arg1Of phosphorylation,necroptotic
R12382 T18736 T18737 arg1Of phosphorylation,of
R12383 T18736 T18741 arg1Of phosphorylation,is
R12384 T18736 T18742 arg1Of phosphorylation,sufficient
R12385 T18736 T18744 arg1Of phosphorylation,increase
R12386 T18738 T18737 arg2Of Thr308,of
R12387 T18738 T18739 arg1Of Thr308,of
R12388 T18740 T18739 arg2Of Akt,of
R12389 T18741 T18732 arg2Of is,demonstrated
R12390 T18741 T18733 arg1Of is,that
R12391 T18742 T18741 arg2Of sufficient,is
R12392 T18744 T18742 arg2Of increase,sufficient
R12393 T18744 T18743 arg1Of increase,to
R12394 T18744 T18747 arg1Of increase,towards
R12395 T18746 T18744 arg2Of activity,increase
R12396 T18746 T18745 arg1Of activity,its
R12397 T18749 T18747 arg2Of number,towards
R12398 T18749 T18748 arg1Of number,a
R12399 T18749 T18750 arg1Of number,of
R12400 T18749 T18758 arg1Of number,as
R12401 T18752 T18751 arg1Of substrates,known
R12402 T18752 T18753 arg1Of substrates,and
R12403 T18753 T18750 arg2Of and,of
R12404 T18756 T18753 arg2Of pathways,and
R12405 T18756 T18754 arg1Of pathways,Akt
R12406 T18756 T18755 arg1Of pathways,effector
R12407 T18758 T18757 arg1Of as,such
R12408 T18761 T18758 arg2Of pathway,as
R12409 T18761 T18759 arg1Of pathway,the
R12410 T18761 T18760 arg1Of pathway,mTORC1
R12411 T18761 T18762 arg1Of pathway,","
R12412 T18761 T18763 arg1Of pathway,which
R12413 T18761 T18768 arg1Of pathway,contributes
R12414 T18766 T18765 arg2Of turn,in
R12415 T18768 T18764 arg1Of contributes,","
R12416 T18768 T18765 arg1Of contributes,in
R12417 T18768 T18767 arg1Of contributes,","
R12418 T18768 T18769 arg1Of contributes,to
R12419 T18771 T18769 arg2Of death,to
R12420 T18771 T18770 arg1Of death,cell
R12421 T18775 T18774 arg1Of data,our
R12422 T18775 T18776 arg1Of data,suggested
R12423 T18776 T18772 arg1Of suggested,Second
R12424 T18776 T18773 arg1Of suggested,","
R12425 T18779 T18778 arg1Of activation,Akt
R12426 T18779 T18780 arg1Of activation,provides
R12427 T18780 T18776 arg2Of provides,suggested
R12428 T18780 T18777 arg1Of provides,that
R12429 T18783 T18780 arg2Of link,provides
R12430 T18783 T18781 arg1Of link,a
R12431 T18783 T18782 arg1Of link,pivotal
R12432 T18783 T18784 arg1Of link,connecting
R12433 T18786 T18784 arg2Of kinase,connecting
R12434 T18786 T18785 arg1Of kinase,RIP1
R12435 T18786 T18787 arg1Of kinase,to
R12436 T18790 T18791 arg1Of signaling,and
R12437 T18792 T18791 arg2Of execution,and
R12438 T18793 T18787 arg2Of events,to
R12439 T18793 T18788 arg2Of events,known
R12440 T18793 T18789 arg1Of events,downstream
R12441 T18793 T18790 arg1Of events,signaling
R12442 T18793 T18792 arg1Of events,execution
R12443 T18793 T18794 arg1Of events,in
R12444 T18793 T18798 arg1Of events,","
R12445 T18793 T18799 arg1Of events,namely
R12446 T18793 T18800 arg1Of events,","
R12447 T18793 T18807 arg1Of events,","
R12448 T18797 T18794 arg2Of cells,in
R12449 T18797 T18795 arg1Of cells,necroptotic
R12450 T18797 T18796 arg1Of cells,L929
R12451 T18802 T18801 arg1Of activation,JNK
R12452 T18802 T18803 arg1Of activation,and
R12453 T18803 T18800 arg2Of and,","
R12454 T18806 T18803 arg2Of synthesis,and
R12455 T18806 T18804 arg1Of synthesis,autocrine
R12456 T18806 T18805 arg1Of synthesis,TNFα
R12457 T18810 T18807 arg2Of event,","
R12458 T18810 T18808 arg1Of event,a
R12459 T18810 T18809 arg1Of event,critical
R12460 T18810 T18811 arg1Of event,in
R12461 T18810 T18813 arg1Of event,in
R12462 T18810 T18816 arg1Of event,[
R12463 T18812 T18811 arg2Of necroptosis,in
R12464 T18815 T18813 arg2Of cells,in
R12465 T18815 T18814 arg1Of cells,L929
R12466 T18817 T18816 arg2Of 15,[
R12467 T18818 T18816 arg3Of ],[
R12468 T18820 T18819 arg2Of order,In
R12469 T18823 T18819 arg3Of test,In
R12470 T18823 T18821 arg1Of test,to
R12471 T18823 T18822 arg1Of test,further
R12472 T18825 T18823 arg2Of model,test
R12473 T18825 T18824 arg1Of model,our
R12474 T18827 T18823 arg1Of we,test
R12475 T18827 T18828 arg1Of we,examined
R12476 T18828 T18819 arg1Of examined,In
R12477 T18828 T18826 arg1Of examined,","
R12478 T18828 T18831 arg1Of examined,after
R12479 T18828 T18837 arg1Of examined,in
R12480 T18830 T18828 arg2Of phosphorylation,examined
R12481 T18830 T18829 arg1Of phosphorylation,Akt
R12482 T18832 T18831 arg2Of inhibition,after
R12483 T18832 T18833 arg1Of inhibition,of
R12484 T18836 T18833 arg2Of kinase,of
R12485 T18836 T18834 arg1Of kinase,a
R12486 T18836 T18835 arg1Of kinase,downstream
R12487 T18839 T18837 arg2Of pathway,in
R12488 T18839 T18838 arg1Of pathway,the
R12489 T18839 T18840 arg1Of pathway,","
R12490 T18841 T18840 arg2Of JNK,","
R12491 T18844 T18845 arg1Of we,found
R12492 T18845 T18842 arg1Of found,However
R12493 T18845 T18843 arg1Of found,","
R12494 T18847 T18848 arg1Of SP600125,","
R12495 T18847 T18849 arg1Of SP600125,which
R12496 T18847 T18850 arg1Of SP600125,protected
R12497 T18847 T18856 arg1Of SP600125,inhibited
R12498 T18847 T18868 arg1Of SP600125,inhibited
R12499 T18850 T18853 arg1Of protected,from
R12500 T18850 T18855 arg1Of protected,and
R12501 T18852 T18850 arg2Of cells,protected
R12502 T18852 T18851 arg1Of cells,L929
R12503 T18854 T18853 arg2Of death,from
R12504 T18855 T18859 arg1Of and,(
R12505 T18856 T18855 arg2Of inhibited,and
R12506 T18858 T18856 arg2Of production,inhibited
R12507 T18858 T18857 arg1Of production,TNFα
R12508 T18861 T18860 arg1Of 2A,Fig.
R12509 T18861 T18862 arg1Of 2A,","
R12510 T18862 T18859 arg2Of ",",(
R12511 T18865 T18862 arg2Of S10A,","
R12512 T18865 T18863 arg1Of S10A,B
R12513 T18865 T18864 arg1Of S10A,S2A
R12514 T18866 T18859 arg3Of ),(
R12515 T18868 T18845 arg2Of inhibited,found
R12516 T18868 T18846 arg1Of inhibited,that
R12517 T18868 T18867 arg1Of inhibited,","
R12518 T18868 T18877 arg1Of inhibited,at
R12519 T18870 T18871 arg1Of basal,and
R12520 T18872 T18871 arg2Of post-treatment,and
R12521 T18874 T18868 arg2Of levels,inhibited
R12522 T18874 T18869 arg1Of levels,both
R12523 T18874 T18870 arg1Of levels,basal
R12524 T18874 T18872 arg1Of levels,post-treatment
R12525 T18874 T18873 arg1Of levels,phosphorylation
R12526 T18874 T18875 arg1Of levels,of
R12527 T18876 T18875 arg2Of Akt,of
R12528 T18879 T18880 arg1Of Ser473,and
R12529 T18880 T18877 arg2Of and,at
R12530 T18880 T18878 arg1Of and,both
R12531 T18880 T18882 arg1Of and,(
R12532 T18881 T18880 arg2Of Thr308,and
R12533 T18884 T18882 arg2Of S10B,(
R12534 T18884 T18883 arg1Of S10B,Fig.
R12535 T18885 T18882 arg3Of ),(
R12536 T18889 T18887 arg2Of published,has
R12537 T18889 T18888 arg2Of published,been
R12538 T18891 T18892 arg1Of SP600125,is
R12539 T18892 T18886 arg1Of is,It
R12540 T18892 T18887 arg1Of is,has
R12541 T18892 T18888 arg1Of is,been
R12542 T18892 T18889 arg2Of is,published
R12543 T18892 T18890 arg1Of is,that
R12544 T18895 T18894 arg1Of non-specific,somewhat
R12545 T18896 T18892 arg2Of inhibitor,is
R12546 T18896 T18893 arg1Of inhibitor,a
R12547 T18896 T18895 arg1Of inhibitor,non-specific
R12548 T18896 T18897 arg1Of inhibitor,that
R12549 T18896 T18898 arg1Of inhibitor,may
R12550 T18896 T18899 arg1Of inhibitor,inhibit
R12551 T18899 T18898 arg2Of inhibit,may
R12552 T18902 T18899 arg2Of subunit,inhibit
R12553 T18902 T18900 arg1Of subunit,the
R12554 T18902 T18901 arg1Of subunit,p110δ
R12555 T18902 T18903 arg1Of subunit,of
R12556 T18904 T18905 arg1Of PI3K,[
R12557 T18904 T18908 arg1Of PI3K,and
R12558 T18906 T18905 arg2Of 41,[
R12559 T18907 T18905 arg3Of ],[
R12560 T18908 T18903 arg2Of and,of
R12561 T18909 T18908 arg2Of PDK1,and
R12562 T18909 T18910 arg1Of PDK1,[
R12563 T18911 T18910 arg2Of 42,[
R12564 T18912 T18910 arg3Of ],[
R12565 T18913 T18914 arg1Of Both,of
R12566 T18913 T18918 arg1Of Both,could
R12567 T18913 T18919 arg1Of Both,inhibit
R12568 T18917 T18914 arg2Of effects,of
R12569 T18917 T18915 arg1Of effects,these
R12570 T18917 T18916 arg1Of effects,off-target
R12571 T18919 T18918 arg2Of inhibit,could
R12572 T18919 T18924 arg1Of inhibit,","
R12573 T18919 T18925 modOf inhibit,precluding
R12574 T18923 T18919 arg2Of levels,inhibit
R12575 T18923 T18920 arg1Of levels,basal
R12576 T18923 T18921 arg1Of levels,Akt
R12577 T18923 T18922 arg1Of levels,phosphorylation
R12578 T18927 T18925 arg2Of use,precluding
R12579 T18927 T18926 arg1Of use,the
R12580 T18927 T18928 arg1Of use,of
R12581 T18927 T18930 arg1Of use,in
R12582 T18929 T18928 arg2Of SP600125,of
R12583 T18932 T18930 arg2Of system,in
R12584 T18932 T18931 arg1Of system,this
R12585 T18936 T18935 arg1Of examine,to
R12586 T18936 T18941 arg1Of examine,","
R12587 T18938 T18936 arg2Of role,examine
R12588 T18938 T18937 arg1Of role,the
R12589 T18938 T18939 arg1Of role,of
R12590 T18940 T18939 arg2Of JNK,of
R12591 T18942 T18936 arg1Of we,examine
R12592 T18942 T18943 arg1Of we,switched
R12593 T18943 T18933 arg1Of switched,Therefore
R12594 T18943 T18934 arg1Of switched,","
R12595 T18943 T18935 modOf switched,to
R12596 T18943 T18944 arg1Of switched,to
R12597 T18947 T18946 arg1Of specific,more
R12598 T18949 T18945 arg1Of inhibitor,a
R12599 T18949 T18947 arg1Of inhibitor,specific
R12600 T18949 T18948 arg1Of inhibitor,JNK
R12601 T18949 T18950 arg1Of inhibitor,","
R12602 T18949 T18958 arg1Of inhibitor,and
R12603 T18952 T18950 arg2Of inhibitor,","
R12604 T18952 T18951 arg1Of inhibitor,JNK
R12605 T18952 T18953 arg1Of inhibitor,VIII
R12606 T18952 T18954 arg1Of inhibitor,[
R12607 T18955 T18954 arg2Of 43,[
R12608 T18956 T18954 arg3Of ],[
R12609 T18958 T18944 arg2Of and,to
R12610 T18958 T18957 arg1Of and,","
R12611 T18959 T18958 arg2Of siRNAs,and
R12612 T18959 T18960 arg1Of siRNAs,against
R12613 T18961 T18962 arg1Of JNK1,and
R12614 T18962 T18960 arg2Of and,against
R12615 T18962 T18964 arg1Of and,(
R12616 T18963 T18962 arg2Of JNK2,and
R12617 T18966 T18964 arg2Of S10B–G,(
R12618 T18966 T18965 arg1Of S10B–G,Fig.
R12619 T18967 T18964 arg3Of ),(
R12620 T18969 T18968 arg2Of expected,As
R12621 T18972 T18973 arg1Of inhibition,or
R12622 T18973 T18971 arg1Of or,specific
R12623 T18973 T18975 arg1Of or,of
R12624 T18973 T18977 arg1Of or,allowed
R12625 T18973 T18984 arg1Of or,inhibiting
R12626 T18973 T18998 arg1Of or,agreeing
R12627 T18974 T18973 arg2Of knockdown,or
R12628 T18976 T18975 arg2Of JNK1/2,of
R12629 T18977 T18968 arg1Of allowed,As
R12630 T18977 T18970 arg1Of allowed,","
R12631 T18977 T18983 arg1Of allowed,while
R12632 T18977 T18991 arg1Of allowed,(
R12633 T18977 T18997 arg1Of allowed,","
R12634 T18977 T18998 modOf allowed,agreeing
R12635 T18978 T18977 arg2Of phosphorylation,allowed
R12636 T18978 T18979 arg1Of phosphorylation,of
R12637 T18978 T18981 arg1Of phosphorylation,on
R12638 T18980 T18979 arg2Of Akt,of
R12639 T18982 T18981 arg2Of Thr308,on
R12640 T18984 T18983 arg2Of inhibiting,while
R12641 T18986 T18984 arg2Of phosphorylation,inhibiting
R12642 T18986 T18985 arg1Of phosphorylation,the
R12643 T18986 T18987 arg1Of phosphorylation,of
R12644 T18986 T18989 arg1Of phosphorylation,at
R12645 T18988 T18987 arg2Of c-Jun,of
R12646 T18990 T18989 arg2Of Ser63,at
R12647 T18993 T18991 arg2Of S10B,(
R12648 T18993 T18992 arg1Of S10B,Fig.
R12649 T18993 T18994 arg1Of S10B,","
R12650 T18995 T18994 arg2Of E,","
R12651 T18996 T18991 arg3Of ),(
R12652 T18998 T18999 arg1Of agreeing,with
R12653 T19001 T18999 arg2Of model,with
R12654 T19001 T19000 arg1Of model,our
R12655 T19002 T19003 arg1Of It,did
R12656 T19002 T19008 arg1Of It,lead
R12657 T19008 T19003 arg2Of lead,did
R12658 T19008 T19004 arg1Of lead,not
R12659 T19008 T19005 arg1Of lead,","
R12660 T19008 T19006 arg1Of lead,however
R12661 T19008 T19007 arg1Of lead,","
R12662 T19008 T19009 arg1Of lead,to
R12663 T19008 T19018 arg1Of lead,(
R12664 T19008 T19028 arg1Of lead,","
R12665 T19008 T19029 modOf lead,suggesting
R12666 T19011 T19009 arg2Of reduction,to
R12667 T19011 T19010 arg1Of reduction,a
R12668 T19011 T19012 arg1Of reduction,in
R12669 T19014 T19013 arg1Of production,TNFα
R12670 T19014 T19015 arg1Of production,or
R12671 T19015 T19012 arg2Of or,in
R12672 T19017 T19015 arg2Of death,or
R12673 T19017 T19016 arg1Of death,cell
R12674 T19020 T19021 arg1Of S10C,","
R12675 T19021 T19023 arg1Of ",",","
R12676 T19022 T19021 arg2Of D,","
R12677 T19023 T19018 arg2Of ",",(
R12678 T19023 T19019 arg1Of ",",Fig.
R12679 T19023 T19025 arg1Of ",",","
R12680 T19024 T19023 arg2Of F,","
R12681 T19026 T19025 arg2Of G,","
R12682 T19027 T19018 arg3Of ),(
R12683 T19032 T19031 arg1Of data,earlier
R12684 T19032 T19033 arg1Of data,with
R12685 T19032 T19040 arg1Of data,could
R12686 T19032 T19041 arg1Of data,reflect
R12687 T19035 T19033 arg2Of protection,with
R12688 T19035 T19034 arg1Of protection,SP600125
R12689 T19035 T19036 arg1Of protection,(
R12690 T19037 T19036 arg2Of Fig.,(
R12691 T19037 T19038 arg1Of Fig.,2
R12692 T19039 T19036 arg3Of ),(
R12693 T19041 T19029 arg2Of reflect,suggesting
R12694 T19041 T19030 arg1Of reflect,that
R12695 T19041 T19040 arg2Of reflect,could
R12696 T19043 T19042 arg1Of effects,off-target
R12697 T19043 T19044 arg1Of effects,of
R12698 T19043 T19049 arg1Of effects,than
R12699 T19046 T19044 arg2Of molecule,of
R12700 T19046 T19045 arg1Of molecule,this
R12701 T19049 T19041 arg2Of than,reflect
R12702 T19049 T19047 arg1Of than,","
R12703 T19049 T19048 arg1Of than,rather
R12704 T19051 T19049 arg2Of inhibition,than
R12705 T19051 T19050 arg1Of inhibition,JNK
R12706 T19053 T19052 arg1Of reports,Previous
R12707 T19053 T19055 arg1Of reports,suggested
R12708 T19055 T19054 arg1Of suggested,also
R12709 T19055 T19070 arg1Of suggested,","
R12710 T19055 T19071 arg1Of suggested,[
R12711 T19055 T19074 arg1Of suggested,","
R12712 T19055 T19075 arg1Of suggested,[
R12713 T19055 T19078 arg1Of suggested,and
R12714 T19058 T19055 arg2Of role,suggested
R12715 T19058 T19056 arg1Of role,a
R12716 T19058 T19057 arg1Of role,critical
R12717 T19058 T19059 arg1Of role,for
R12718 T19058 T19061 arg1Of role,in
R12719 T19060 T19059 arg2Of c-Jun,for
R12720 T19062 T19063 arg1Of necroptosis,and
R12721 T19064 T19063 arg2Of autocrine,and
R12722 T19066 T19061 arg2Of synthesis,in
R12723 T19066 T19062 arg1Of synthesis,necroptosis
R12724 T19066 T19064 arg1Of synthesis,autocrine
R12725 T19066 T19065 arg1Of synthesis,TNFα
R12726 T19066 T19067 arg1Of synthesis,[
R12727 T19068 T19067 arg2Of 13,[
R12728 T19069 T19067 arg3Of ],[
R12729 T19072 T19071 arg2Of 14,[
R12730 T19073 T19071 arg3Of ],[
R12731 T19076 T19075 arg2Of 15,[
R12732 T19077 T19075 arg3Of ],[
R12733 T19079 T19080 arg1Of we,confirmed
R12734 T19080 T19078 arg2Of confirmed,and
R12735 T19082 T19080 arg2Of conclusions,confirmed
R12736 T19082 T19081 arg1Of conclusions,these
R12737 T19082 T19083 arg1Of conclusions,using
R12738 T19086 T19083 arg2Of knockdown,using
R12739 T19086 T19084 arg1Of knockdown,c-Jun
R12740 T19086 T19085 arg1Of knockdown,siRNA
R12741 T19086 T19087 arg1Of knockdown,(
R12742 T19089 T19087 arg2Of S10H–J,(
R12743 T19089 T19088 arg1Of S10H–J,Fig.
R12744 T19090 T19087 arg3Of ),(
R12745 T19095 T19093 arg2Of case,in
R12746 T19095 T19094 arg1Of case,this
R12747 T19098 T19097 arg1Of phosphorylation,Thr308
R12748 T19098 T19099 arg1Of phosphorylation,was
R12749 T19098 T19100 arg2Of phosphorylation,reduced
R12750 T19100 T19091 arg1Of reduced,Notably
R12751 T19100 T19092 arg1Of reduced,","
R12752 T19100 T19093 arg1Of reduced,in
R12753 T19100 T19096 arg1Of reduced,","
R12754 T19100 T19099 arg2Of reduced,was
R12755 T19100 T19101 arg1Of reduced,after
R12756 T19103 T19101 arg2Of induction,after
R12757 T19103 T19102 arg1Of induction,the
R12758 T19103 T19104 arg1Of induction,of
R12759 T19105 T19104 arg2Of necroptosis,of
R12760 T19110 T19108 arg1Of production,autocrine
R12761 T19110 T19109 arg1Of production,TNFα
R12762 T19110 T19111 arg1Of production,","
R12763 T19110 T19112 arg1Of production,dependent
R12764 T19110 T19116 arg1Of production,may
R12765 T19110 T19117 arg1Of production,create
R12766 T19112 T19113 arg1Of dependent,on
R12767 T19114 T19113 arg2Of c-Jun,on
R12768 T19117 T19106 arg1Of create,Thus
R12769 T19117 T19107 arg1Of create,","
R12770 T19117 T19115 arg1Of create,","
R12771 T19117 T19116 arg2Of create,may
R12772 T19120 T19117 arg2Of loop,create
R12773 T19120 T19118 arg1Of loop,a
R12774 T19120 T19119 arg1Of loop,feedback
R12775 T19120 T19121 arg1Of loop,that
R12776 T19120 T19122 arg1Of loop,contributes
R12777 T19122 T19123 arg1Of contributes,to
R12778 T19126 T19123 arg2Of activation,to
R12779 T19126 T19124 arg1Of activation,the
R12780 T19126 T19125 arg2Of activation,delayed
R12781 T19126 T19127 arg1Of activation,of
R12782 T19128 T19127 arg2Of Akt.,of
R12783 T19130 T19122 arg2Of is,contributes
R12784 T19130 T19131 arg1Of is,also
R12785 T19132 T19130 arg2Of important,is
R12786 T19134 T19129 arg1Of note,It
R12787 T19134 T19130 arg1Of note,is
R12788 T19134 T19132 arg1Of note,important
R12789 T19134 T19133 arg1Of note,to
R12790 T19136 T19137 arg1Of we,observed
R12791 T19137 T19134 arg2Of observed,note
R12792 T19137 T19135 arg1Of observed,that
R12793 T19137 T19147 arg1Of observed,after
R12794 T19140 T19137 arg2Of increase,observed
R12795 T19140 T19138 arg1Of increase,an
R12796 T19140 T19139 arg1Of increase,overall
R12797 T19140 T19141 arg1Of increase,in
R12798 T19144 T19141 arg2Of level,in
R12799 T19144 T19142 arg1Of level,the
R12800 T19144 T19143 arg1Of level,protein
R12801 T19144 T19145 arg1Of level,of
R12802 T19146 T19145 arg2Of c-Jun,of
R12803 T19148 T19147 arg2Of treatment,after
R12804 T19148 T19149 arg1Of treatment,of
R12805 T19148 T19152 arg1Of treatment,with
R12806 T19151 T19149 arg2Of cells,of
R12807 T19151 T19150 arg1Of cells,L929
R12808 T19153 T19154 arg1Of zVAD.fmk,or
R12809 T19154 T19152 arg2Of or,with
R12810 T19154 T19156 arg1Of or,","
R12811 T19154 T19157 arg1Of or,which
R12812 T19154 T19158 arg1Of or,was
R12813 T19155 T19154 arg2Of TNFα,or
R12814 T19160 T19161 arg1Of Akt,and
R12815 T19161 T19158 arg2Of and,was
R12816 T19161 T19159 arg1Of and,both
R12817 T19161 T19163 arg1Of and,(
R12818 T19162 T19161 arg2Of mTOR-dependent,and
R12819 T19165 T19163 arg2Of 6E,(
R12820 T19165 T19164 arg1Of 6E,Fig.
R12821 T19165 T19166 arg1Of 6E,","
R12822 T19167 T19166 arg2Of F,","
R12823 T19168 T19163 arg3Of ),(
R12824 T19171 T19169 arg1Of data,These
R12825 T19171 T19170 arg1Of data,new
R12826 T19171 T19172 arg1Of data,led
R12827 T19172 T19174 arg1Of led,to
R12828 T19173 T19172 arg2Of us,led
R12829 T19176 T19178 arg1Of unexpected,but
R12830 T19178 T19177 arg1Of but,","
R12831 T19179 T19178 arg2Of important,but
R12832 T19180 T19174 arg2Of conclusion,to
R12833 T19180 T19175 arg1Of conclusion,an
R12834 T19180 T19176 arg1Of conclusion,unexpected
R12835 T19180 T19179 arg1Of conclusion,important
R12836 T19182 T19183 arg1Of c-Jun,is
R12837 T19182 T19184 arg1Of c-Jun,critical
R12838 T19183 T19180 arg2Of is,conclusion
R12839 T19183 T19181 arg1Of is,that
R12840 T19183 T19187 arg1Of is,","
R12841 T19183 T19188 arg1Of is,while
R12842 T19184 T19183 arg2Of critical,is
R12843 T19184 T19185 arg1Of critical,for
R12844 T19186 T19185 arg2Of necroptosis,for
R12845 T19190 T19189 arg1Of activity,JNK
R12846 T19190 T19191 arg1Of activity,may
R12847 T19190 T19192 arg1Of activity,serve
R12848 T19190 T19202 arg1Of activity,may
R12849 T19190 T19203 arg1Of activity,be
R12850 T19190 T19205 arg1Of activity,redundant
R12851 T19190 T19224 arg1Of activity,dispensable
R12852 T19192 T19191 arg2Of serve,may
R12853 T19192 T19193 arg1Of serve,as
R12854 T19192 T19201 arg1Of serve,but
R12855 T19196 T19193 arg2Of marker,as
R12856 T19196 T19194 arg1Of marker,a
R12857 T19196 T19195 arg1Of marker,useful
R12858 T19196 T19197 arg1Of marker,of
R12859 T19199 T19197 arg2Of activation,of
R12860 T19199 T19198 arg1Of activation,pathway
R12861 T19201 T19188 arg2Of but,while
R12862 T19201 T19200 arg1Of but,","
R12863 T19203 T19201 arg2Of be,but
R12864 T19203 T19202 arg2Of be,may
R12865 T19205 T19204 arg1Of redundant,either
R12866 T19205 T19206 arg1Of redundant,(
R12867 T19205 T19223 arg1Of redundant,or
R12868 T19208 T19207 arg1Of phosphorylation,e.g.
R12869 T19208 T19209 arg1Of phosphorylation,of
R12870 T19208 T19211 arg1Of phosphorylation,on
R12871 T19208 T19217 arg1Of phosphorylation,may
R12872 T19208 T19218 arg1Of phosphorylation,occur
R12873 T19210 T19209 arg2Of c-Jun,of
R12874 T19213 T19211 arg2Of site,on
R12875 T19213 T19212 arg1Of site,a
R12876 T19213 T19214 arg1Of site,other
R12877 T19214 T19215 arg1Of other,than
R12878 T19216 T19215 arg2Of Ser63,than
R12879 T19218 T19206 arg2Of occur,(
R12880 T19218 T19217 arg2Of occur,may
R12881 T19218 T19219 arg1Of occur,[
R12882 T19220 T19219 arg2Of 44,[
R12883 T19221 T19219 arg3Of ],[
R12884 T19222 T19206 arg3Of ),(
R12885 T19223 T19203 arg2Of or,be
R12886 T19224 T19223 arg2Of dispensable,or
R12887 T19224 T19225 arg1Of dispensable,functionally
R12888 T19227 T19226 arg2Of addition,In
R12889 T19229 T19230 arg1Of researchers,need
R12890 T19229 T19232 arg1Of researchers,use
R12891 T19229 T19235 arg1Of researchers,using
R12892 T19230 T19226 arg1Of need,In
R12893 T19230 T19228 arg1Of need,","
R12894 T19232 T19230 arg2Of use,need
R12895 T19232 T19231 arg1Of use,to
R12896 T19232 T19234 arg1Of use,when
R12897 T19233 T19232 arg2Of caution,use
R12898 T19235 T19234 arg2Of using,when
R12899 T19236 T19235 arg2Of SP600125,using
R12900 T19236 T19237 arg1Of SP600125,due
R12901 T19237 T19238 arg1Of due,to
R12902 T19241 T19238 arg2Of effects,to
R12903 T19241 T19239 arg1Of effects,potantial
R12904 T19241 T19240 arg1Of effects,off-target
R22259 T32332 T32333 arg1Of Model,of
R22260 T32332 T32341 arg1Of Model,in
R22261 T32334 T32335 arg1Of RIP1,","
R22262 T32335 T32337 arg1Of ",",and
R22263 T32336 T32335 arg2Of Akt,","
R22264 T32337 T32333 arg2Of and,of
R22265 T32339 T32338 arg1Of dependent,JNK
R22266 T32340 T32337 arg2Of signaling,and
R22267 T32340 T32339 arg1Of signaling,dependent
R22268 T32344 T32341 arg2Of cells,in
R22269 T32344 T32342 arg1Of cells,necroptotic
R22270 T32344 T32343 arg1Of cells,L929
R22271 T32346 T32345 arg1Of phosphorylation,Akt
R22272 T32346 T32347 arg1Of phosphorylation,at
R22273 T32346 T32349 arg1Of phosphorylation,during
R22274 T32346 T32351 arg1Of phosphorylation,requires
R22275 T32348 T32347 arg2Of Thr308,at
R22276 T32350 T32349 arg2Of necroptosis,during
R22277 T32352 T32351 arg2Of inputs,requires
R22278 T32352 T32353 arg1Of inputs,from
R22279 T32356 T32355 arg1Of factors,growth
R22280 T32356 T32357 arg1Of factors,and
R22281 T32357 T32353 arg2Of and,from
R22282 T32357 T32354 arg1Of and,both
R22283 T32359 T32357 arg2Of kinase,and
R22284 T32359 T32358 arg1Of kinase,RIP1
R22285 T32360 T32361 arg1Of Downstream,from
R22286 T32362 T32361 arg2Of Akt,from
R22287 T32365 T32364 arg1Of activation,JNK
R22288 T32365 T32366 arg1Of activation,leads
R22289 T32366 T32360 arg1Of leads,Downstream
R22290 T32366 T32363 arg1Of leads,","
R22291 T32366 T32367 arg1Of leads,to
R22292 T32369 T32367 arg2Of synthesis,to
R22293 T32369 T32368 arg1Of synthesis,TNFα
R22294 T32370 T32371 arg1Of Activation,of
R22295 T32370 T32373 arg1Of Activation,during
R22296 T32370 T32376 arg1Of Activation,leads
R22297 T32372 T32371 arg2Of Akt,of
R22298 T32374 T32373 arg2Of necroptosis,during
R22299 T32376 T32375 arg1Of leads,also
R22300 T32378 T32376 arg2Of phosphorylation,leads
R22301 T32378 T32377 arg1Of phosphorylation,the
R22302 T32378 T32379 arg1Of phosphorylation,of
R22303 T32383 T32379 arg2Of substrates,of
R22304 T32383 T32380 arg1Of substrates,several
R22305 T32383 T32381 arg2Of substrates,known
R22306 T32383 T32382 arg1Of substrates,Akt
R22307 T32383 T32384 arg1Of substrates,","
R22308 T32383 T32386 arg1Of substrates,as
R22309 T32386 T32385 arg1Of as,such
R22310 T32387 T32386 arg2Of mTOR,as
R22311 T32387 T32388 arg1Of mTOR,","
R22312 T32387 T32389 arg1Of mTOR,which
R22313 T32387 T32390 arg1Of mTOR,contribute
R22314 T32390 T32391 arg1Of contribute,to
R22315 T32393 T32391 arg2Of execution,to
R22316 T32393 T32392 arg1Of execution,the
R22317 T32393 T32394 arg1Of execution,of
R22318 T32393 T32397 arg1Of execution,in
R22319 T32396 T32394 arg2Of death,of
R22320 T32396 T32395 arg1Of death,necroptotic
R22321 T32399 T32397 arg2Of cells,in
R22322 T32399 T32398 arg1Of cells,L929

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T18387 4039-4047 Antecedent denotes increase
T18386 4131-4136 Anaphor denotes which
R12163 T18386 T18387 boundBy which,increase

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T32312 1340-1344 Protein denotes TNFα
T32311 1282-1286 Protein denotes RIP1
T32310 1123-1127 Protein denotes RIP1
T18413 4411-4416 Protein denotes c-Jun
T18412 4252-4257 Protein denotes c-Jun
T18411 4125-4129 Protein denotes TNFα
T18410 4072-4077 Protein denotes c-Jun
T18409 3897-3902 Protein denotes c-Jun
T18408 3867-3871 Protein denotes TNFα
T18407 3720-3725 Protein denotes c-Jun
T18406 3647-3651 Protein denotes TNFα
T18405 3612-3617 Protein denotes c-Jun
T18404 3369-3373 Protein denotes TNFα
T18403 3270-3275 Protein denotes c-Jun
T18402 3187-3188 Protein denotes 2
T18401 3182-3186 Protein denotes JNK1
T18400 3113-3117 Protein denotes JNK2
T18399 3104-3108 Protein denotes JNK1
T18398 2836-2840 Protein denotes PDK1
T18397 2805-2818 Protein denotes p110δ subunit
T18396 2564-2568 Protein denotes TNFα
T18395 2282-2286 Protein denotes TNFα
T18394 2155-2159 Protein denotes RIP1
T18393 898-902 Protein denotes RIP1
T18392 822-829 Protein denotes Myr-Akt
T18391 735-742 Protein denotes Myr-Akt
T18390 359-363 Protein denotes RIP1
T18389 103-107 Protein denotes RIP1
T18388 9-13 Protein denotes RIP1

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T32426 1465-1469 http://www.uniprot.org/uniprot/P42345 denotes mTOR
T32425 1340-1344 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T19398 4154-4158 http://www.uniprot.org/uniprot/P42345 denotes mTOR
T19397 4411-4416 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T19396 4252-4257 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T19395 4072-4077 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T19394 3897-3902 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T19393 3720-3725 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T19392 3612-3617 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T19391 3270-3275 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T19390 4125-4129 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T19389 3867-3871 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T19388 3647-3651 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T19387 3369-3373 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T19386 2564-2568 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T19385 2282-2286 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T19384 4146-4149 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19383 3977-3980 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19382 3216-3219 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19381 2900-2903 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19380 2668-2671 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19379 2398-2401 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19378 2105-2108 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19377 1980-1983 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19376 1896-1899 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19375 1762-1765 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19374 1666-1669 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19373 1612-1615 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19372 1576-1579 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19371 1547-1550 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19370 968-971 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19369 826-829 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19368 739-742 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19367 720-723 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19366 666-669 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19365 533-536 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19364 295-298 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19363 15-18 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T19362 4146-4149 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19361 3977-3980 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19354 1896-1899 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19353 1762-1765 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19352 1666-1669 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19351 1612-1615 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19350 1576-1579 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19349 1547-1550 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19348 968-971 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19347 826-829 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19346 739-742 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19345 720-723 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19344 666-669 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19343 533-536 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19342 295-298 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19341 15-18 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19340 4146-4149 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19339 3977-3980 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19338 3216-3219 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19337 2900-2903 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19336 2668-2671 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19335 2398-2401 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19334 2105-2108 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19333 1980-1983 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19332 1896-1899 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19331 1762-1765 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19330 1666-1669 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19329 1612-1615 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19328 1576-1579 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19327 1547-1550 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19326 968-971 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19325 826-829 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19324 739-742 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19323 720-723 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19322 666-669 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19321 533-536 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19320 295-298 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19319 15-18 http://www.uniprot.org/uniprot/P31749 denotes Akt
T19318 2155-2159 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T19317 898-902 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T19316 359-363 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T19315 103-107 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T19314 9-13 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T32424 1441-1444 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T32423 1370-1373 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T32422 1311-1314 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T32421 1188-1191 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T32420 1129-1132 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T32419 1441-1444 http://www.uniprot.org/uniprot/P31751 denotes Akt
T32418 1370-1373 http://www.uniprot.org/uniprot/P31751 denotes Akt
T32417 1311-1314 http://www.uniprot.org/uniprot/P31751 denotes Akt
T32416 1188-1191 http://www.uniprot.org/uniprot/P31751 denotes Akt
T32415 1129-1132 http://www.uniprot.org/uniprot/P31751 denotes Akt
T32414 1441-1444 http://www.uniprot.org/uniprot/P31749 denotes Akt
T32413 1370-1373 http://www.uniprot.org/uniprot/P31749 denotes Akt
T32412 1311-1314 http://www.uniprot.org/uniprot/P31749 denotes Akt
T32411 1188-1191 http://www.uniprot.org/uniprot/P31749 denotes Akt
T32410 1129-1132 http://www.uniprot.org/uniprot/P31749 denotes Akt
T32409 1282-1286 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T32408 1123-1127 http://www.uniprot.org/uniprot/Q13546 denotes RIP1
T19360 3216-3219 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19359 2900-2903 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19358 2668-2671 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19357 2398-2401 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19356 2105-2108 http://www.uniprot.org/uniprot/P31751 denotes Akt
T19355 1980-1983 http://www.uniprot.org/uniprot/P31751 denotes Akt

GO-BP

Id Subject Object Predicate Lexical cue
T32324 1520-1525 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T32323 1345-1354 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T32322 1263-1269 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T32321 1381-1392 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T32320 1225-1236 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T32319 1381-1392 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T32318 1225-1236 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T32317 1408-1423 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T32316 1192-1207 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T32315 1151-1160 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T32314 1316-1319 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T32313 1137-1140 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18470 2836-2840 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T18469 2822-2826 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18468 3652-3661 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T18467 2287-2296 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T18466 3393-3398 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T18465 2544-2549 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T18464 2066-2071 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T18463 1709-1714 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T18462 3388-3398 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T18461 2061-2071 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T18460 1704-1714 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T18459 650-662 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T18458 641-662 http://purl.obolibrary.org/obo/GO_0051668 denotes membrane localization
T18457 634-662 http://purl.obolibrary.org/obo/GO_0072659 denotes plasma membrane localization
T18456 634-662 http://purl.obolibrary.org/obo/GO_0044856 denotes plasma membrane localization
T18455 774-780 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T18454 605-611 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T18453 4392-4407 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18452 3787-3802 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18451 3251-3266 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18450 3197-3212 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18449 2904-2919 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18448 2642-2657 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18447 2402-2417 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18446 1867-1882 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18445 949-964 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18444 514-529 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18443 415-430 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T18442 4274-4285 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T18441 3838-3849 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T18440 3621-3632 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T18439 2318-2329 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T18438 1804-1815 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T18437 875-886 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T18436 491-502 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T18435 192-203 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T18434 3825-3849 http://purl.obolibrary.org/obo/GO_0070266 denotes induction of necroptosis
T18433 862-886 http://purl.obolibrary.org/obo/GO_0070266 denotes induction of necroptosis
T18432 3838-3849 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T18431 3621-3632 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T18430 2318-2329 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T18429 1804-1815 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T18428 875-886 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T18427 491-502 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T18426 192-203 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T18425 125-143 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathways
T18424 2187-2196 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18423 333-342 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18422 125-134 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T18421 4293-4296 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18420 3544-3547 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18419 3060-3063 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18418 3045-3048 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18417 3009-3012 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18416 2474-2477 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18415 2253-2256 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18414 23-26 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-MF

Id Subject Object Predicate Lexical cue
T18473 2474-2477 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18472 2253-2256 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18471 23-26 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18480 2836-2840 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T18479 2822-2826 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T18478 4293-4296 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18477 3544-3547 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18476 3060-3063 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18475 3045-3048 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T18474 3009-3012 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T32326 1316-1319 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T32325 1137-1140 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-CC

Id Subject Object Predicate Lexical cue
T32328 1534-1539 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T32327 1181-1186 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18490 2014-2020 http://purl.obolibrary.org/obo/GO_0031931 denotes mTORC1
T18489 702-710 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T18488 641-649 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T18487 634-649 http://purl.obolibrary.org/obo/GO_0005886 denotes plasma membrane
T18482 1723-1728 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18481 174-179 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18486 4102-4107 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18485 2533-2538 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18484 2338-2343 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18483 2238-2243 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T32304 1356-1540 Sentence denotes Activation of Akt during necroptosis also leads the phosphorylation of several known Akt substrates, such as mTOR, which contribute to the execution of necroptotic death in L929 cells.
T32303 1295-1355 Sentence denotes Downstream from Akt, JNK activation leads to TNFα synthesis.
T32302 1188-1294 Sentence denotes Akt phosphorylation at Thr308 during necroptosis requires inputs from both growth factors and RIP1 kinase.
T32301 1114-1187 Sentence denotes Model of RIP1, Akt and JNK dependent signaling in necroptotic L929 cells.
T18334 4489-4590 Sentence denotes In addition, researchers need to use caution when using SP600125 due to potantial off-target effects.
T18333 4182-4488 Sentence denotes These new data led us to an unexpected, but important conclusion that c-Jun is critical for necroptosis, while JNK activity may serve as a useful marker of pathway activation, but may be either redundant (e.g. phosphorylation of c-Jun on a site other than Ser63 may occur [44]) or dispensable functionally.
T18332 3851-4181 Sentence denotes Thus, autocrine TNFα production, dependent on c-Jun, may create a feedback loop that contributes to the delayed activation of Akt. It is also important to note that we observed an overall increase in the protein level of c-Jun after treatment of L929 cells with zVAD.fmk or TNFα, which was both Akt and mTOR-dependent (Fig. 6E,F).
T18331 3757-3850 Sentence denotes Notably, in this case, Thr308 phosphorylation was reduced after the induction of necroptosis.
T18330 3560-3756 Sentence denotes Previous reports also suggested a critical role for c-Jun in necroptosis and autocrine TNFα synthesis [13], [14], [15] and we confirmed these conclusions using c-Jun siRNA knockdown (Fig. S10H–J).
T18329 3325-3559 Sentence denotes It did not, however, lead to a reduction in TNFα production or cell death (Fig. S10C,D,F,G), suggesting that earlier data with SP600125 protection (Fig. 2) could reflect off-target effects of this molecule, rather than JNK inhibition.
T18328 3133-3324 Sentence denotes As expected, specific inhibition or knockdown of JNK1/2 allowed phosphorylation of Akt on Thr308 while inhibiting the phosphorylation of c-Jun at Ser63 (Fig. S10B,E), agreeing with our model.
T18327 2975-3132 Sentence denotes Therefore, to examine the role of JNK, we switched to a more specific JNK inhibitor, JNK inhibitor VIII [43], and siRNAs against JNK1 and JNK2 (Fig. S10B–G).
T18326 2847-2974 Sentence denotes Both of these off-target effects could inhibit basal Akt phosphorylation levels, precluding the use of SP600125 in this system.
T18325 2711-2846 Sentence denotes It has been published that SP600125 is a somewhat non-specific inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42].
T18324 2479-2710 Sentence denotes However, we found that SP600125, which protected L929 cells from death and inhibited TNFα production (Fig. 2A,B S2A S10A), inhibited both basal and post-treatment phosphorylation levels of Akt at both Ser473 and Thr308 (Fig. S10B).
T18323 2350-2478 Sentence denotes In order to further test our model, we examined Akt phosphorylation after inhibition of a downstream kinase in the pathway, JNK.
T18322 2073-2349 Sentence denotes Second, our data suggested that Akt activation provides a pivotal link connecting RIP1 kinase to known downstream signaling and execution events in necroptotic L929 cells, namely, JNK activation and autocrine TNFα synthesis, a critical event in necroptosis in L929 cells [15].
T18321 1817-2072 Sentence denotes First, we demonstrated that selective necroptotic phosphorylation of Thr308 of Akt is sufficient to increase its activity towards a number of known substrates and Akt effector pathways such as the mTORC1 pathway, which, in turn, contributes to cell death.
T18320 1730-1816 Sentence denotes We also investigated downstream Akt-dependent pathways that contribute to necroptosis.
T18319 1541-1729 Sentence denotes Using Akt inhibitors, knockdown of Akt isoforms, and the expression of Akt mutants, we showed that necroptotic activation of Akt is indispensable for this form of cell death in L929 cells.
T18318 888-1069 Sentence denotes A second, RIP1 kinase-dependent input is required for Thr308 phosphorylation of Akt in response to caspase inhibition and is essential for the propagation of the necroptotic signal.
T18317 790-887 Sentence denotes At the same time, expression of Myr-Akt alone is not sufficient for the induction of necroptosis.
T18316 568-789 Sentence denotes The first input, which is induced by growth factors, leads to the plasma membrane localization of Akt. Expression of a constitutively membrane-targeted Akt construct, Myr-Akt, overcomes the requirement for growth factors.
T18315 458-567 Sentence denotes According to our model (Fig. 9), necroptosis-associated phosphorylation of Akt requires two distinct signals.
T18314 258-457 Sentence denotes Altogether, our results suggest that Akt kinase is specifically engaged in signaling downstream from RIP1 kinase, which leads to a selective increase in its phosphorylation on Thr308, but not Ser473.
T18313 73-257 Sentence denotes In this study we investigated RIP1 kinase-dependent signaling pathways using mouse fibrosarcoma L929 cells that die by necroptosis when treated with the pan-caspase inhibitor zVAD.fmk.
T18312 0-72 Sentence denotes Model of RIP1, Akt and JNK Dependent Signaling in Necroptotic L929 Cells
T228 0-72 Sentence denotes Model of RIP1, Akt and JNK Dependent Signaling in Necroptotic L929 Cells
T229 73-257 Sentence denotes In this study we investigated RIP1 kinase-dependent signaling pathways using mouse fibrosarcoma L929 cells that die by necroptosis when treated with the pan-caspase inhibitor zVAD.fmk.
T230 258-457 Sentence denotes Altogether, our results suggest that Akt kinase is specifically engaged in signaling downstream from RIP1 kinase, which leads to a selective increase in its phosphorylation on Thr308, but not Ser473.
T231 458-567 Sentence denotes According to our model (Fig. 9), necroptosis-associated phosphorylation of Akt requires two distinct signals.
T232 568-670 Sentence denotes The first input, which is induced by growth factors, leads to the plasma membrane localization of Akt.
T233 671-789 Sentence denotes Expression of a constitutively membrane-targeted Akt construct, Myr-Akt, overcomes the requirement for growth factors.
T234 790-887 Sentence denotes At the same time, expression of Myr-Akt alone is not sufficient for the induction of necroptosis.
T235 888-1069 Sentence denotes A second, RIP1 kinase-dependent input is required for Thr308 phosphorylation of Akt in response to caspase inhibition and is essential for the propagation of the necroptotic signal.
T236 1070-1187 Sentence denotes 10.1371/journal.pone.0056576.g009 Figure 9 Model of RIP1, Akt and JNK dependent signaling in necroptotic L929 cells.
T237 1188-1294 Sentence denotes Akt phosphorylation at Thr308 during necroptosis requires inputs from both growth factors and RIP1 kinase.
T238 1295-1355 Sentence denotes Downstream from Akt, JNK activation leads to TNFα synthesis.
T239 1356-1540 Sentence denotes Activation of Akt during necroptosis also leads the phosphorylation of several known Akt substrates, such as mTOR, which contribute to the execution of necroptotic death in L929 cells.
T240 1541-1729 Sentence denotes Using Akt inhibitors, knockdown of Akt isoforms, and the expression of Akt mutants, we showed that necroptotic activation of Akt is indispensable for this form of cell death in L929 cells.
T241 1730-1816 Sentence denotes We also investigated downstream Akt-dependent pathways that contribute to necroptosis.
T242 1817-2072 Sentence denotes First, we demonstrated that selective necroptotic phosphorylation of Thr308 of Akt is sufficient to increase its activity towards a number of known substrates and Akt effector pathways such as the mTORC1 pathway, which, in turn, contributes to cell death.
T243 2073-2349 Sentence denotes Second, our data suggested that Akt activation provides a pivotal link connecting RIP1 kinase to known downstream signaling and execution events in necroptotic L929 cells, namely, JNK activation and autocrine TNFα synthesis, a critical event in necroptosis in L929 cells [15].
T244 2350-2478 Sentence denotes In order to further test our model, we examined Akt phosphorylation after inhibition of a downstream kinase in the pathway, JNK.
T245 2479-2710 Sentence denotes However, we found that SP600125, which protected L929 cells from death and inhibited TNFα production (Fig. 2A,B S2A S10A), inhibited both basal and post-treatment phosphorylation levels of Akt at both Ser473 and Thr308 (Fig. S10B).
T246 2711-2846 Sentence denotes It has been published that SP600125 is a somewhat non-specific inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42].
T247 2847-2974 Sentence denotes Both of these off-target effects could inhibit basal Akt phosphorylation levels, precluding the use of SP600125 in this system.
T248 2975-3132 Sentence denotes Therefore, to examine the role of JNK, we switched to a more specific JNK inhibitor, JNK inhibitor VIII [43], and siRNAs against JNK1 and JNK2 (Fig. S10B–G).
T249 3133-3324 Sentence denotes As expected, specific inhibition or knockdown of JNK1/2 allowed phosphorylation of Akt on Thr308 while inhibiting the phosphorylation of c-Jun at Ser63 (Fig. S10B,E), agreeing with our model.
T250 3325-3559 Sentence denotes It did not, however, lead to a reduction in TNFα production or cell death (Fig. S10C,D,F,G), suggesting that earlier data with SP600125 protection (Fig. 2) could reflect off-target effects of this molecule, rather than JNK inhibition.
T251 3560-3756 Sentence denotes Previous reports also suggested a critical role for c-Jun in necroptosis and autocrine TNFα synthesis [13], [14], [15] and we confirmed these conclusions using c-Jun siRNA knockdown (Fig. S10H–J).
T252 3757-3850 Sentence denotes Notably, in this case, Thr308 phosphorylation was reduced after the induction of necroptosis.
T253 3851-3981 Sentence denotes Thus, autocrine TNFα production, dependent on c-Jun, may create a feedback loop that contributes to the delayed activation of Akt.
T254 3982-4181 Sentence denotes It is also important to note that we observed an overall increase in the protein level of c-Jun after treatment of L929 cells with zVAD.fmk or TNFα, which was both Akt and mTOR-dependent (Fig. 6E,F).
T255 4182-4488 Sentence denotes These new data led us to an unexpected, but important conclusion that c-Jun is critical for necroptosis, while JNK activity may serve as a useful marker of pathway activation, but may be either redundant (e.g. phosphorylation of c-Jun on a site other than Ser63 may occur [44]) or dispensable functionally.
T256 4489-4590 Sentence denotes In addition, researchers need to use caution when using SP600125 due to potantial off-target effects.

simple1

Id Subject Object Predicate Lexical cue
T32331 1340-1344 Protein denotes TNFα
T32330 1282-1286 Protein denotes RIP1
T32329 1123-1127 Protein denotes RIP1
T18516 4411-4416 Protein denotes c-Jun
T18515 4252-4257 Protein denotes c-Jun
T18514 4125-4129 Protein denotes TNFα
T18513 4072-4077 Protein denotes c-Jun
T18512 3897-3902 Protein denotes c-Jun
T18511 3867-3871 Protein denotes TNFα
T18510 3720-3725 Protein denotes c-Jun
T18509 3647-3651 Protein denotes TNFα
T18508 3612-3617 Protein denotes c-Jun
T18507 3369-3373 Protein denotes TNFα
T18506 3270-3275 Protein denotes c-Jun
T18505 3187-3188 Protein denotes 2
T18504 3182-3186 Protein denotes JNK1
T18503 3113-3117 Protein denotes JNK2
T18502 3104-3108 Protein denotes JNK1
T18501 2836-2840 Protein denotes PDK1
T18500 2805-2818 Protein denotes p110δ subunit
T18499 2564-2568 Protein denotes TNFα
T18498 2282-2286 Protein denotes TNFα
T18497 2155-2159 Protein denotes RIP1
T18496 898-902 Protein denotes RIP1
T18495 822-829 Protein denotes Myr-Akt
T18494 735-742 Protein denotes Myr-Akt
T18493 359-363 Protein denotes RIP1
T18492 103-107 Protein denotes RIP1
T18491 9-13 Protein denotes RIP1

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T19313 4392-4407 Phosphorylation denotes phosphorylation
T19312 4039-4047 Positive_regulation denotes increase
T19311 3884-3893 Regulation denotes dependent
T19310 3872-3882 Gene_expression denotes production
T19309 3732-3741 Negative_regulation denotes knockdown
T19308 3652-3661 Gene_expression denotes synthesis
T19307 3603-3607 Positive_regulation denotes role
T19306 3356-3365 Negative_regulation denotes reduction
T19305 3374-3384 Gene_expression denotes production
T19304 3251-3266 Phosphorylation denotes phosphorylation
T19303 3236-3246 Negative_regulation denotes inhibiting
T19302 3155-3165 Negative_regulation denotes inhibition
T19301 3169-3178 Negative_regulation denotes knockdown
T19300 2793-2800 Negative_regulation denotes inhibit
T19299 2554-2563 Negative_regulation denotes inhibited
T19298 2569-2579 Gene_expression denotes production
T19297 2287-2296 Gene_expression denotes synthesis
T19296 808-818 Gene_expression denotes expression
T19295 843-853 Positive_regulation denotes sufficient
T19294 671-681 Gene_expression denotes Expression
T19293 4411-4416 Protein denotes c-Jun
T19292 4252-4257 Protein denotes c-Jun
T19291 4125-4129 Protein denotes TNFα
T19290 4072-4077 Protein denotes c-Jun
T19289 3897-3902 Protein denotes c-Jun
T19288 3867-3871 Protein denotes TNFα
T19287 3720-3725 Protein denotes c-Jun
T19286 3647-3651 Protein denotes TNFα
T19268 9-13 Protein denotes RIP1
T19274 2155-2159 Protein denotes RIP1
T19273 898-902 Protein denotes RIP1
T19272 822-829 Protein denotes Myr-Akt
T19271 735-742 Protein denotes Myr-Akt
T19270 359-363 Protein denotes RIP1
T19269 103-107 Protein denotes RIP1
T19285 3612-3617 Protein denotes c-Jun
T19284 3369-3373 Protein denotes TNFα
T19283 3270-3275 Protein denotes c-Jun
T19282 3187-3188 Protein denotes 2
T19281 3182-3186 Protein denotes JNK1
T19280 3113-3117 Protein denotes JNK2
T19279 3104-3108 Protein denotes JNK1
T19278 2836-2840 Protein denotes PDK1
T19277 2805-2818 Protein denotes p110δ subunit
T19276 2564-2568 Protein denotes TNFα
T19275 2282-2286 Protein denotes TNFα
T32407 1345-1354 Gene_expression denotes synthesis
T32406 1331-1336 Positive_regulation denotes leads
T32405 1340-1344 Protein denotes TNFα
T32404 1282-1286 Protein denotes RIP1
T32403 1123-1127 Protein denotes RIP1
R12906 T19271 T19294 themeOf Myr-Akt,Expression
R12907 T19272 T19296 themeOf Myr-Akt,expression
R12908 T19275 T19297 themeOf TNFα,synthesis
R12909 T19276 T19298 themeOf TNFα,production
R12910 T19277 T19300 themeOf p110δ subunit,inhibit
R12911 T19281 T19302 themeOf JNK1,inhibition
R12912 T19281 T19301 themeOf JNK1,knockdown
R12913 T19282 T19302 themeOf 2,inhibition
R12914 T19282 T19301 themeOf 2,knockdown
R12915 T19283 T19304 themeOf c-Jun,phosphorylation
R12916 T19284 T19305 themeOf TNFα,production
R12917 T19285 T19307 causeOf c-Jun,role
R12918 T19286 T19308 themeOf TNFα,synthesis
R12919 T19287 T19309 themeOf c-Jun,knockdown
R12920 T19288 T19310 themeOf TNFα,production
R12921 T19289 T19311 causeOf c-Jun,dependent
R12922 T19290 T19312 themeOf c-Jun,increase
R12923 T19293 T19313 themeOf c-Jun,phosphorylation
R12924 T19296 T19295 themeOf expression,sufficient
R12925 T19298 T19299 themeOf production,inhibited
R12926 T19302 T19301 themeOf inhibition,knockdown
R12927 T19302 T19301 themeOf inhibition,knockdown
R12928 T19304 T19303 themeOf phosphorylation,inhibiting
R12929 T19305 T19306 themeOf production,reduction
R12930 T19308 T19307 themeOf synthesis,role
R12931 T19310 T19311 themeOf production,dependent
R22323 T32405 T32407 themeOf TNFα,synthesis
R22324 T32407 T32406 themeOf synthesis,leads

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T32439 1331-1336 Positive_regulation denotes leads
T32438 1345-1354 Gene_expression denotes synthesis
T32437 1340-1344 Protein denotes TNFα
T32436 1282-1286 Protein denotes RIP1
T32435 1123-1127 Protein denotes RIP1
T19537 4392-4407 Phosphorylation denotes phosphorylation
T19536 4039-4047 Positive_regulation denotes increase
T19535 3884-3893 Positive_regulation denotes dependent
T19534 3872-3882 Gene_expression denotes production
T19533 3857-3866 Positive_regulation denotes autocrine
T19532 3732-3741 Negative_regulation denotes knockdown
T19531 3652-3661 Gene_expression denotes synthesis
T19510 3720-3725 Protein denotes c-Jun
T19509 3647-3651 Protein denotes TNFα
T19508 3612-3617 Protein denotes c-Jun
T19507 3369-3373 Protein denotes TNFα
T19506 3270-3275 Protein denotes c-Jun
T19505 3187-3188 Protein denotes 2
T19504 3182-3186 Protein denotes JNK1
T19503 3113-3117 Protein denotes JNK2
T19502 3104-3108 Protein denotes JNK1
T19501 2836-2840 Protein denotes PDK1
T19500 2805-2818 Protein denotes p110δ subunit
T19499 2564-2568 Protein denotes TNFα
T19498 2282-2286 Protein denotes TNFα
T19497 2155-2159 Protein denotes RIP1
T19496 898-902 Protein denotes RIP1
T19495 822-829 Protein denotes Myr-Akt
T19494 735-742 Protein denotes Myr-Akt
T19493 359-363 Protein denotes RIP1
T19492 103-107 Protein denotes RIP1
T19491 9-13 Protein denotes RIP1
T19522 2569-2579 Gene_expression denotes production
T19521 2554-2563 Negative_regulation denotes inhibited
T19520 2287-2296 Gene_expression denotes synthesis
T19519 903-919 Regulation denotes kinase-dependent
T19518 808-818 Gene_expression denotes expression
T19517 671-681 Gene_expression denotes Expression
T19516 4411-4416 Protein denotes c-Jun
T19515 4252-4257 Protein denotes c-Jun
T19514 4125-4129 Protein denotes TNFα
T19513 4072-4077 Protein denotes c-Jun
T19512 3897-3902 Protein denotes c-Jun
T19511 3867-3871 Protein denotes TNFα
T19530 3356-3365 Negative_regulation denotes reduction
T19529 3374-3384 Gene_expression denotes production
T19528 3169-3178 Negative_regulation denotes knockdown
T19527 3251-3266 Phosphorylation denotes phosphorylation
T19526 3155-3165 Negative_regulation denotes inhibition
T19525 3236-3246 Negative_regulation denotes inhibiting
T19524 2774-2783 Negative_regulation denotes inhibitor
T19523 2793-2800 Negative_regulation denotes inhibit
R12974 T19494 T19517 themeOf Myr-Akt,Expression
R12975 T19495 T19518 themeOf Myr-Akt,expression
R12976 T19496 T19519 themeOf RIP1,kinase-dependent
R12977 T19498 T19520 themeOf TNFα,synthesis
R12978 T19499 T19522 themeOf TNFα,production
R12979 T19500 T19523 themeOf p110δ subunit,inhibit
R12980 T19504 T19526 themeOf JNK1,inhibition
R12981 T19504 T19528 themeOf JNK1,knockdown
R12982 T19505 T19526 themeOf 2,inhibition
R12983 T19505 T19528 themeOf 2,knockdown
R12984 T19506 T19527 themeOf c-Jun,phosphorylation
R12985 T19507 T19529 themeOf TNFα,production
R12986 T19509 T19531 themeOf TNFα,synthesis
R12987 T19510 T19532 themeOf c-Jun,knockdown
R12988 T19511 T19534 themeOf TNFα,production
R12989 T19512 T19535 causeOf c-Jun,dependent
R12990 T19513 T19536 themeOf c-Jun,increase
R12991 T19516 T19537 themeOf c-Jun,phosphorylation
R12992 T19522 T19521 themeOf production,inhibited
R12993 T19523 T19524 themeOf inhibit,inhibitor
R12994 T19526 T19528 themeOf inhibition,knockdown
R12995 T19526 T19528 themeOf inhibition,knockdown
R12996 T19527 T19525 themeOf phosphorylation,inhibiting
R12997 T19529 T19530 themeOf production,reduction
R12998 T19534 T19533 themeOf production,autocrine
R12999 T19534 T19535 themeOf production,dependent
R22327 T32437 T32438 themeOf TNFα,synthesis
R22328 T32438 T32439 themeOf synthesis,leads

DLUT931

Id Subject Object Predicate Lexical cue
T32431 1331-1336 Positive_regulation denotes leads
T32430 1345-1354 Gene_expression denotes synthesis
T32429 1340-1344 Protein denotes TNFα
T32428 1282-1286 Protein denotes RIP1
T32427 1123-1127 Protein denotes RIP1
T19432 2569-2579 Gene_expression denotes production
T19431 2287-2296 Gene_expression denotes synthesis
T19430 2144-2154 Positive_regulation denotes connecting
T19429 903-919 Positive_regulation denotes kinase-dependent
T19428 843-853 Positive_regulation denotes sufficient
T19427 808-818 Gene_expression denotes expression
T19426 671-681 Gene_expression denotes Expression
T19425 378-383 Positive_regulation denotes leads
T19424 4411-4416 Protein denotes c-Jun
T19423 4252-4257 Protein denotes c-Jun
T19422 4125-4129 Protein denotes TNFα
T19421 4072-4077 Protein denotes c-Jun
T19420 3897-3902 Protein denotes c-Jun
T19419 3867-3871 Protein denotes TNFα
T19418 3720-3725 Protein denotes c-Jun
T19417 3647-3651 Protein denotes TNFα
T19416 3612-3617 Protein denotes c-Jun
T19415 3369-3373 Protein denotes TNFα
T19414 3270-3275 Protein denotes c-Jun
T19413 3187-3188 Protein denotes 2
T19412 3182-3186 Protein denotes JNK1
T19411 3113-3117 Protein denotes JNK2
T19410 3104-3108 Protein denotes JNK1
T19409 2836-2840 Protein denotes PDK1
T19408 2805-2818 Protein denotes p110δ subunit
T19407 2564-2568 Protein denotes TNFα
T19406 2282-2286 Protein denotes TNFα
T19405 2155-2159 Protein denotes RIP1
T19404 898-902 Protein denotes RIP1
T19403 822-829 Protein denotes Myr-Akt
T19402 735-742 Protein denotes Myr-Akt
T19401 359-363 Protein denotes RIP1
T19400 103-107 Protein denotes RIP1
T19399 9-13 Protein denotes RIP1
T19444 4392-4407 Phosphorylation denotes phosphorylation
T19443 4039-4047 Positive_regulation denotes increase
T19442 3857-3866 Positive_regulation denotes autocrine
T19441 3884-3893 Positive_regulation denotes dependent
T19440 3872-3882 Gene_expression denotes production
T19439 3726-3731 Negative_regulation denotes siRNA
T19438 3732-3741 Negative_regulation denotes knockdown
T19437 3637-3646 Positive_regulation denotes autocrine
T19436 3356-3365 Negative_regulation denotes reduction
T19435 3374-3384 Gene_expression denotes production
T19434 3251-3266 Phosphorylation denotes phosphorylation
T19433 2554-2563 Negative_regulation denotes inhibited
R12932 T19401 T19425 themeOf RIP1,leads
R12933 T19402 T19426 themeOf Myr-Akt,Expression
R12934 T19403 T19427 themeOf Myr-Akt,expression
R12935 T19404 T19429 themeOf RIP1,kinase-dependent
R12936 T19405 T19430 themeOf RIP1,connecting
R12937 T19406 T19431 themeOf TNFα,synthesis
R12938 T19407 T19432 themeOf TNFα,production
R12939 T19414 T19434 themeOf c-Jun,phosphorylation
R12940 T19415 T19435 themeOf TNFα,production
R12941 T19417 T19437 themeOf TNFα,autocrine
R12942 T19418 T19438 themeOf c-Jun,knockdown
R12943 T19419 T19440 themeOf TNFα,production
R12944 T19420 T19441 causeOf c-Jun,dependent
R12945 T19421 T19443 themeOf c-Jun,increase
R12946 T19424 T19444 themeOf c-Jun,phosphorylation
R12947 T19427 T19428 themeOf expression,sufficient
R12948 T19432 T19433 themeOf production,inhibited
R12949 T19435 T19436 themeOf production,reduction
R12950 T19438 T19439 themeOf knockdown,siRNA
R12951 T19439 T19438 themeOf siRNA,knockdown
R12952 T19440 T19441 themeOf production,dependent
R12953 T19440 T19442 themeOf production,autocrine
R22325 T32429 T32430 themeOf TNFα,synthesis
R22326 T32430 T32431 themeOf synthesis,leads

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue Speculation
T32572 1404-1469 Phosphorylation denotes the phosphorylation of several known Akt substrates, such as mTOR
T32571 1188-1236 Phosphorylation denotes Akt phosphorylation at Thr308 during necroptosis
T32570 1188-1293 Regulation denotes Akt phosphorylation at Thr308 during necroptosis requires inputs from both growth factors and RIP1 kinase
T32569 1356-1392 Positive_regulation denotes Activation of Akt during necroptosis
T32568 1137-1160 Positive_regulation denotes JNK dependent signaling
T32567 1311-1315 Protein denotes Akt,
T32566 1424-1469 Protein denotes of several known Akt substrates, such as mTOR
T32565 1164-1186 Entity denotes necroptotic L929 cells
T32564 1367-1373 Protein denotes of Akt
T32563 1176-1180 Entity denotes L929
T32562 1427-1464 Entity denotes several known Akt substrates, such as
T32561 1337-1354 Protein denotes to TNFα synthesis
T32560 1188-1191 Protein denotes Akt
T32559 1211-1217 Entity denotes Thr308
T32558 1441-1444 Protein denotes Akt
T32557 1123-1127 Protein denotes RIP1
T32556 1282-1286 Protein denotes RIP1
T32555 1311-1330 Protein denotes Akt, JNK activation
T32554 1129-1132 Protein denotes Akt
T32553 1282-1293 Protein denotes RIP1 kinase
T32552 1137-1140 Protein denotes JNK
T19901 2774-2845 Negative_regulation denotes inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42] true
T19900 2774-2845 Negative_regulation denotes inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42] true
T19899 3857-3903 Regulation denotes autocrine TNFα production, dependent on c-Jun,
T19898 1640-1669 Positive_regulation denotes necroptotic activation of Akt
T19897 942-971 Phosphorylation denotes Thr308 phosphorylation of Akt
T19896 3197-3219 Phosphorylation denotes phosphorylation of Akt
T19895 3951-3980 Positive_regulation denotes the delayed activation of Akt
T19894 3247-3284 Phosphorylation denotes the phosphorylation of c-Jun at Ser63
T19893 2512-2579 Negative_regulation denotes which protected L929 cells from death and inhibited TNFα production
T19892 2564-2579 Gene_expression denotes TNFα production
T19891 3857-3903 Gene_expression denotes autocrine TNFα production, dependent on c-Jun,
T19890 1845-1899 Phosphorylation denotes selective necroptotic phosphorylation of Thr308 of Akt
T19889 2386-2450 Phosphorylation denotes we examined Akt phosphorylation after inhibition of a downstream
T19888 491-536 Phosphorylation denotes necroptosis-associated phosphorylation of Akt
T19887 3544-3558 Negative_regulation denotes JNK inhibition
T19886 987-1005 Negative_regulation denotes caspase inhibition
T19885 4392-4416 Phosphorylation denotes phosphorylation of c-Jun
T19884 2253-2267 Positive_regulation denotes JNK activation
T19883 2894-2927 Phosphorylation denotes basal Akt phosphorylation levels,
T19882 3951-3980 Negative_regulation denotes the delayed activation of Akt
T19881 808-829 Gene_expression denotes expression of Myr-Akt
T19880 3369-3384 Gene_expression denotes TNFα production
T19879 4247-4257 Protein denotes that c-Jun
T19878 2774-2845 Entity denotes inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42]
T19877 663-669 Protein denotes of Akt
T19876 3029-3084 Entity denotes a more specific JNK inhibitor, JNK inhibitor VIII [43],
T19875 2451-2477 Protein denotes kinase in the pathway, JNK
T19874 2272-2296 Protein denotes autocrine TNFα synthesis
T19873 3412-3416 Entity denotes F,G)
T19872 4408-4416 Protein denotes of c-Jun
T19871 2581-2584 Protein denotes Fig
T19870 2680-2686 Entity denotes Ser473
T19869 4072-4077 Protein denotes c-Jun
T19868 735-742 Protein denotes Myr-Akt
T19867 3187-3188 Protein denotes 2
T19866 3182-3188 Protein denotes JNK1/2
T19865 295-298 Protein denotes Akt
T19864 3867-3871 Protein denotes TNFα
T19863 238-247 Entity denotes inhibitor
T19862 3614-3678 Protein denotes Jun in necroptosis and autocrine TNFα synthesis [13], [14], [15]
T19861 819-829 Protein denotes of Myr-Akt
T19860 2398-2401 Protein denotes Akt
T19859 3223-3229 Entity denotes Thr308
T19858 1984-2009 Entity denotes effector pathways such as
T19857 62-66 Entity denotes L929
T19856 2947-2958 Entity denotes of SP600125
T19855 3060-3083 Entity denotes JNK inhibitor VIII [43]
T19854 2836-2845 Protein denotes PDK1 [42]
T19853 4154-4168 Protein denotes mTOR-dependent
T19852 359-363 Protein denotes RIP1
T19851 2155-2159 Protein denotes RIP1
T19850 3369-3373 Protein denotes TNFα
T19849 1956-1975 Entity denotes of known substrates
T19848 3720-3725 Protein denotes c-Jun
T19847 3279-3284 Entity denotes Ser63
T19846 1547-1562 Entity denotes Akt inhibitors,
T19845 9-13 Protein denotes RIP1
T19844 2900-2903 Protein denotes Akt
T19843 2333-2348 Entity denotes L929 cells [15]
T19842 3182-3188 Protein denotes JNK1/2
T19841 702-719 Entity denotes membrane-targeted
T19840 15-18 Protein denotes Akt
T19839 720-723 Protein denotes Akt
T19838 295-305 Protein denotes Akt kinase
T19837 3267-3275 Protein denotes of c-Jun
T19836 4545-4553 Entity denotes SP600125
T19835 942-948 Entity denotes Thr308
T19834 630-649 Entity denotes the plasma membrane
T19833 3637-3678 Protein denotes autocrine TNFα synthesis [13], [14], [15]
T19832 3400-3403 Protein denotes Fig
T19831 1883-1899 Entity denotes of Thr308 of Akt
T19830 222-256 Entity denotes the pan-caspase inhibitor zVAD.fmk
T19829 1762-1775 Protein denotes Akt-dependent
T19828 3104-3108 Protein denotes JNK1
T19827 1609-1623 Protein denotes of Akt mutants
T19826 103-107 Protein denotes RIP1
T19825 2668-2671 Protein denotes Akt
T19824 3544-3547 Protein denotes JNK
T19823 222-256 Protein denotes the pan-caspase inhibitor zVAD.fmk
T19822 359-371 Protein denotes RIP1 kinase,
T19821 3213-3219 Protein denotes of Akt
T19820 2497-2511 Entity denotes that SP600125,
T19819 3113-3117 Protein denotes JNK2
T19818 3517-3530 Entity denotes this molecule
T19817 3780-3786 Entity denotes Thr308
T19816 3045-3048 Protein denotes JNK
T19815 50-72 Entity denotes Necroptotic L929 Cells
T19814 2691-2697 Entity denotes Thr308
T19813 3060-3083 Protein denotes JNK inhibitor VIII [43]
T19812 108-124 Protein denotes kinase-dependent
T19811 2155-2196 Protein denotes RIP1 kinase to known downstream signaling
T19810 2253-2256 Protein denotes JNK
T19809 4420-4426 Entity denotes a site
T19808 3060-3063 Protein denotes JNK
T19807 4113-4121 Entity denotes zVAD.fmk
T19806 3974-3980 Protein denotes of Akt
T19805 3119-3130 Protein denotes Fig. S10B–G
T19804 450-456 Entity denotes Ser473
T19803 4146-4149 Protein denotes Akt
T19802 2010-2028 Entity denotes the mTORC1 pathway
T19801 898-902 Protein denotes RIP1
T19800 1576-1579 Protein denotes Akt
T19799 2100-2108 Protein denotes that Akt
T19798 4125-4129 Protein denotes TNFα
T19797 4293-4296 Protein denotes JNK
T19796 2461-2477 Protein denotes the pathway, JNK
T19795 1980-1983 Protein denotes Akt
T19794 431-440 Entity denotes on Thr308
T19793 1547-1550 Protein denotes Akt
T19792 23-36 Protein denotes JNK Dependent
T19791 3894-3902 Protein denotes on c-Jun
T19790 2801-2831 Protein denotes the p110δ subunit of PI3K [41]
T19789 2233-2237 Entity denotes L929
T19788 150-179 Entity denotes mouse fibrosarcoma L929 cells
T19787 2564-2568 Protein denotes TNFα
T19786 530-536 Protein denotes of Akt
T19785 903-919 Protein denotes kinase-dependent
T19784 965-971 Protein denotes of Akt
T19783 2221-2243 Entity denotes necroptotic L929 cells
T19782 2822-2826 Protein denotes PI3K
T19781 987-994 Protein denotes caspase
T19780 4438-4443 Entity denotes Ser63
T19779 3006-3012 Protein denotes of JNK
T19778 4048-4062 Protein denotes in the protein
T19777 150-179 Entity denotes mouse fibrosarcoma L929 cells
T19776 1896-1899 Protein denotes Akt
T19775 3473-3476 Protein denotes Fig
T19774 1663-1669 Protein denotes of Akt
R13122 T19774 T19898 themeOf of Akt,necroptotic activation of Akt
R13123 T19776 T19890 themeOf Akt,selective necroptotic phosphorylation of Thr308 of Akt
R13124 T19781 T19886 themeOf caspase,caspase inhibition
R13125 T19784 T19897 themeOf of Akt,Thr308 phosphorylation of Akt
R13126 T19786 T19888 themeOf of Akt,necroptosis-associated phosphorylation of Akt
R13127 T19787 T19892 themeOf TNFα,TNFα production
R13128 T19790 T19900 themeOf the p110δ subunit of PI3K [41],inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42]
R13129 T19791 T19899 causeOf on c-Jun,"autocrine TNFα production, dependent on c-Jun,"
R13130 T19806 T19895 themeOf of Akt,the delayed activation of Akt
R13131 T19810 T19884 themeOf JNK,JNK activation
R13132 T19821 T19896 themeOf of Akt,phosphorylation of Akt
R13133 T19824 T19887 themeOf JNK,JNK inhibition
R13134 T19831 T19776 partOf of Thr308 of Akt,Akt
R13135 T19831 T19890 siteOf of Thr308 of Akt,selective necroptotic phosphorylation of Thr308 of Akt
R13136 T19835 T19784 partOf Thr308,of Akt
R13137 T19835 T19897 siteOf Thr308,Thr308 phosphorylation of Akt
R13138 T19837 T19894 themeOf of c-Jun,the phosphorylation of c-Jun at Ser63
R13139 T19844 T19883 themeOf Akt,"basal Akt phosphorylation levels,"
R13140 T19847 T19837 partOf Ser63,of c-Jun
R13141 T19847 T19894 siteOf Ser63,the phosphorylation of c-Jun at Ser63
R13142 T19850 T19880 themeOf TNFα,TNFα production
R13143 T19854 T19901 themeOf PDK1 [42],inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42]
R13144 T19860 T19889 themeOf Akt,we examined Akt phosphorylation after inhibition of a downstream
R13145 T19861 T19881 themeOf of Myr-Akt,expression of Myr-Akt
R13146 T19864 T19891 themeOf TNFα,"autocrine TNFα production, dependent on c-Jun,"
R13147 T19872 T19885 themeOf of c-Jun,phosphorylation of c-Jun
R13148 T19878 T19900 causeOf inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42],inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42]
R13149 T19878 T19901 causeOf inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42],inhibitor that may inhibit the p110δ subunit of PI3K [41] and PDK1 [42]
R13150 T19891 T19899 themeOf "autocrine TNFα production, dependent on c-Jun,","autocrine TNFα production, dependent on c-Jun,"
R13151 T19892 T19893 themeOf TNFα production,which protected L929 cells from death and inhibited TNFα production
R13152 T19895 T19882 themeOf the delayed activation of Akt,the delayed activation of Akt
R22423 T32552 T32568 causeOf JNK,JNK dependent signaling
R22424 T32559 T32560 partOf Thr308,Akt
R22425 T32559 T32571 siteOf Thr308,Akt phosphorylation at Thr308 during necroptosis
R22426 T32560 T32571 themeOf Akt,Akt phosphorylation at Thr308 during necroptosis
R22427 T32564 T32569 themeOf of Akt,Activation of Akt during necroptosis
R22428 T32566 T32572 themeOf "of several known Akt substrates, such as mTOR","the phosphorylation of several known Akt substrates, such as mTOR"
R22429 T32571 T32570 themeOf Akt phosphorylation at Thr308 during necroptosis,Akt phosphorylation at Thr308 during necroptosis requires inputs from both growth factors and RIP1 kinase

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T20404 3309-3313 IN denotes with
T32515 1455-1456 , denotes ,
T32514 1445-1455 VBZ denotes substrates
T32513 1441-1444 NNP denotes Akt
T32512 1435-1440 VBN denotes known
T32511 1427-1434 JJ denotes several
T32510 1424-1426 IN denotes of
T32509 1408-1423 NN denotes phosphorylation
T32508 1404-1407 DT denotes the
T32507 1398-1403 VBZ denotes leads
T32506 1393-1397 RB denotes also
T32505 1381-1392 NN denotes necroptosis
T32504 1374-1380 IN denotes during
T32503 1370-1373 NNP denotes Akt
T32502 1367-1369 IN denotes of
T32501 1356-1366 NNP denotes Activation
T32500 1354-1355 . denotes .
T32499 1345-1354 NN denotes synthesis
T32498 1340-1344 VB denotes TNFα
T32497 1337-1339 TO denotes to
T32496 1331-1336 VBZ denotes leads
T32495 1320-1330 NN denotes activation
T32494 1316-1319 NNP denotes JNK
T32493 1314-1315 , denotes ,
T32492 1311-1314 NNP denotes Akt
T32491 1306-1310 IN denotes from
T32490 1295-1305 NNP denotes Downstream
T32489 1293-1294 . denotes .
T32488 1287-1293 NN denotes kinase
T32487 1282-1286 CD denotes RIP1
T32486 1278-1281 CC denotes and
T32485 1270-1277 NNS denotes factors
T32484 1263-1269 NN denotes growth
T32483 1258-1262 DT denotes both
T32482 1253-1257 IN denotes from
T32481 1246-1252 NNS denotes inputs
T32480 1237-1245 VBZ denotes requires
T32479 1225-1236 NN denotes necroptosis
T32478 1218-1224 IN denotes during
T32477 1211-1217 CD denotes Thr308
T32476 1208-1210 IN denotes at
T32475 1192-1207 NN denotes phosphorylation
T32474 1188-1191 NNP denotes Akt
T32473 1186-1187 . denotes .
T32472 1181-1186 NNS denotes cells
T32471 1176-1180 NNP denotes L929
T32470 1164-1175 JJ denotes necroptotic
T32469 1161-1163 IN denotes in
T32468 1151-1160 VBG denotes signaling
T32467 1141-1150 JJ denotes dependent
T32466 1137-1140 NNP denotes JNK
T32465 1133-1136 CC denotes and
T32464 1129-1132 NNP denotes Akt
T32463 1127-1128 , denotes ,
T32462 1123-1127 NNP denotes RIP1
T32461 1120-1122 IN denotes of
T32460 1114-1119 NNP denotes Model
T32531 1539-1540 . denotes .
T32530 1534-1539 NNS denotes cells
T32529 1529-1533 CD denotes L929
T32528 1526-1528 IN denotes in
T32527 1520-1525 NN denotes death
T32526 1508-1519 JJ denotes necroptotic
T32525 1505-1507 IN denotes of
T32524 1495-1504 NN denotes execution
T32523 1491-1494 DT denotes the
T32522 1488-1490 TO denotes to
T32521 1477-1487 VBP denotes contribute
T32520 1471-1476 WDT denotes which
T32519 1469-1470 , denotes ,
T32518 1465-1469 NNP denotes mTOR
T32517 1462-1464 IN denotes as
T32516 1457-1461 JJ denotes such
T20657 4589-4590 . denotes .
T20656 4582-4589 NNS denotes effects
T20655 4571-4581 JJ denotes off-target
T20654 4561-4570 JJ denotes potantial
T20653 4558-4560 TO denotes to
T20652 4554-4557 JJ denotes due
T20651 4545-4553 CD denotes SP600125
T20650 4539-4544 VBG denotes using
T20649 4534-4538 WRB denotes when
T20648 4526-4533 NN denotes caution
T20647 4522-4525 VB denotes use
T20646 4519-4521 TO denotes to
T20645 4514-4518 VBP denotes need
T20644 4502-4513 NNS denotes researchers
T20643 4500-4501 , denotes ,
T20642 4492-4500 NN denotes addition
T20641 4489-4491 IN denotes In
T20640 4487-4488 . denotes .
T20639 4475-4487 RB denotes functionally
T20638 4463-4474 JJ denotes dispensable
T20637 4460-4462 CC denotes or
T20636 4458-4459 -RRB- denotes )
T20635 4457-4458 NNP denotes ]
T20634 4455-4457 CD denotes 44
T20633 4454-4455 NNP denotes [
T20632 4448-4453 VB denotes occur
T20631 4444-4447 MD denotes may
T20630 4438-4443 CD denotes Ser63
T20629 4433-4437 IN denotes than
T20628 4427-4432 JJ denotes other
T20627 4422-4426 NN denotes site
T20626 4420-4421 DT denotes a
T20625 4417-4419 IN denotes on
T20624 4411-4416 NN denotes c-Jun
T20623 4408-4410 IN denotes of
T20622 4392-4407 NN denotes phosphorylation
T20621 4387-4391 FW denotes e.g.
T20620 4386-4387 -LRB- denotes (
T20619 4376-4385 JJ denotes redundant
T20618 4369-4375 RB denotes either
T20617 4366-4368 VB denotes be
T20616 4362-4365 MD denotes may
T20615 4358-4361 CC denotes but
T20614 4356-4357 , denotes ,
T20613 4346-4356 NN denotes activation
T20612 4338-4345 NN denotes pathway
T20611 4335-4337 IN denotes of
T20610 4328-4334 NN denotes marker
T20609 4321-4327 JJ denotes useful
T20608 4319-4320 DT denotes a
T20607 4316-4318 IN denotes as
T20606 4310-4315 VB denotes serve
T20605 4306-4309 MD denotes may
T20604 4297-4305 NN denotes activity
T20603 4293-4296 NNP denotes JNK
T20602 4287-4292 IN denotes while
T20601 4285-4286 , denotes ,
T20600 4274-4285 NN denotes necroptosis
T20599 4270-4273 IN denotes for
T20598 4261-4269 JJ denotes critical
T20597 4258-4260 VBZ denotes is
T20596 4252-4257 NNP denotes c-Jun
T20595 4247-4251 WDT denotes that
T20582 4180-4181 . denotes .
T20581 4179-4180 -RRB- denotes )
T20580 4178-4179 NN denotes F
T20579 4177-4178 , denotes ,
T20578 4175-4177 NNP denotes 6E
T20577 4170-4174 NNP denotes Fig.
T20576 4169-4170 -LRB- denotes (
T20575 4154-4168 NNP denotes mTOR-dependent
T20574 4150-4153 CC denotes and
T20573 4146-4149 NNP denotes Akt
T20572 4141-4145 DT denotes both
T20571 4137-4140 VBD denotes was
T20570 4131-4136 WDT denotes which
T20569 4129-4130 , denotes ,
T20568 4125-4129 NNP denotes TNFα
T20567 4122-4124 CC denotes or
T20566 4113-4121 NNP denotes zVAD.fmk
T20565 4108-4112 IN denotes with
T20564 4102-4107 NNS denotes cells
T20563 4097-4101 CD denotes L929
T20562 4094-4096 IN denotes of
T20561 4084-4093 NN denotes treatment
T20560 4078-4083 IN denotes after
T20559 4072-4077 JJ denotes c-Jun
T20558 4069-4071 IN denotes of
T20557 4063-4068 NN denotes level
T20556 4055-4062 NN denotes protein
T20555 4051-4054 DT denotes the
T20554 4048-4050 IN denotes in
T20553 4039-4047 NN denotes increase
T20552 4031-4038 JJ denotes overall
T20551 4028-4030 DT denotes an
T20550 4019-4027 VBD denotes observed
T20549 4016-4018 PRP denotes we
T20548 4011-4015 IN denotes that
T20547 4006-4010 VB denotes note
T20546 4003-4005 TO denotes to
T20545 3993-4002 JJ denotes important
T20544 3988-3992 RB denotes also
T20543 3985-3987 VBZ denotes is
T20542 3982-3984 PRP denotes It
T20541 3980-3981 . denotes .
T20540 3977-3980 NNP denotes Akt
T20539 3974-3976 IN denotes of
T20538 3963-3973 NN denotes activation
T20537 3955-3962 VBN denotes delayed
T20536 3951-3954 DT denotes the
T20535 3948-3950 TO denotes to
T20534 3936-3947 VBZ denotes contributes
T20533 3931-3935 WDT denotes that
T20532 3926-3930 NN denotes loop
T20531 3917-3925 NN denotes feedback
T20530 3915-3916 DT denotes a
T20529 3908-3914 VB denotes create
T20528 3904-3907 MD denotes may
T20527 3902-3903 , denotes ,
T20526 3897-3902 JJ denotes c-Jun
T20525 3894-3896 IN denotes on
T20524 3884-3893 JJ denotes dependent
T20523 3882-3883 , denotes ,
T20522 3872-3882 NN denotes production
T20521 3867-3871 NN denotes TNFα
T20520 3857-3866 NN denotes autocrine
T20519 3855-3856 , denotes ,
T20518 3851-3855 RB denotes Thus
T20517 3849-3850 . denotes .
T20516 3838-3849 NN denotes necroptosis
T20515 3835-3837 IN denotes of
T20514 3825-3834 NN denotes induction
T20513 3821-3824 DT denotes the
T20512 3815-3820 IN denotes after
T20511 3807-3814 VBN denotes reduced
T20510 3803-3806 VBD denotes was
T20509 3787-3802 NN denotes phosphorylation
T20508 3780-3786 NNP denotes Thr308
T20507 3778-3779 , denotes ,
T20506 3774-3778 NN denotes case
T20505 3769-3773 DT denotes this
T20504 3766-3768 IN denotes in
T20503 3764-3765 , denotes ,
T20502 3757-3764 RB denotes Notably
T20501 3755-3756 . denotes .
T20500 3754-3755 -RRB- denotes )
T20499 3753-3754 NNP denotes J
T20498 3748-3752 CD denotes S10H
T20497 3746-3747 . denotes .
T20496 3743-3746 NNP denotes Fig
T20495 3742-3743 -LRB- denotes (
T20494 3732-3741 VBN denotes knockdown
T20493 3726-3731 NN denotes siRNA
T20492 3720-3725 JJ denotes c-Jun
T20491 3714-3719 VBG denotes using
T20490 3702-3713 NNS denotes conclusions
T20489 3696-3701 DT denotes these
T20488 3686-3695 VBD denotes confirmed
T20487 3683-3685 PRP denotes we
T20486 3679-3682 CC denotes and
T20485 3677-3678 NNP denotes ]
T20484 3675-3677 CD denotes 15
T20483 3674-3675 NNP denotes [
T20482 3672-3673 , denotes ,
T20481 3671-3672 NNP denotes ]
T20480 3669-3671 CD denotes 14
T20479 3668-3669 NNP denotes [
T20478 3666-3667 , denotes ,
T20477 3665-3666 NNP denotes ]
T20476 3663-3665 CD denotes 13
T20475 3662-3663 NNP denotes [
T20474 3652-3661 NN denotes synthesis
T20473 3647-3651 NNP denotes TNFα
T20472 3637-3646 NN denotes autocrine
T20471 3633-3636 CC denotes and
T20470 3621-3632 NN denotes necroptosis
T20469 3618-3620 IN denotes in
T20468 3612-3617 NN denotes c-Jun
T20467 3608-3611 IN denotes for
T20466 3603-3607 NN denotes role
T20465 3594-3602 JJ denotes critical
T20464 3592-3593 DT denotes a
T20463 3582-3591 VBD denotes suggested
T20462 3577-3581 RB denotes also
T20461 3569-3576 NNS denotes reports
T20460 3560-3568 JJ denotes Previous
T20459 3558-3559 . denotes .
T20458 3548-3558 NN denotes inhibition
T20457 3544-3547 NNP denotes JNK
T20456 3539-3543 IN denotes than
T20455 3532-3538 RB denotes rather
T20454 3530-3531 , denotes ,
T20453 3522-3530 NN denotes molecule
T20452 3517-3521 DT denotes this
T20451 3514-3516 IN denotes of
T20450 3506-3513 NNS denotes effects
T20449 3495-3505 JJ denotes off-target
T20448 3487-3494 VB denotes reflect
T20447 3481-3486 MD denotes could
T20446 3479-3480 -RRB- denotes )
T20445 3478-3479 LS denotes 2
T20444 3473-3477 FW denotes Fig.
T20443 3472-3473 -LRB- denotes (
T20442 3461-3471 NN denotes protection
T20441 3452-3460 CD denotes SP600125
T20440 3447-3451 IN denotes with
T20439 3442-3446 NNS denotes data
T20438 3434-3441 JJR denotes earlier
T20437 3429-3433 IN denotes that
T20436 3418-3428 VBG denotes suggesting
T20435 3416-3417 , denotes ,
T20434 3415-3416 -RRB- denotes )
T20433 3414-3415 NNP denotes G
T20432 3413-3414 , denotes ,
T20431 3412-3413 NN denotes F
T20430 3411-3412 , denotes ,
T20429 3410-3411 NNP denotes D
T20428 3409-3410 , denotes ,
T20427 3405-3409 CD denotes S10C
T20426 3403-3404 . denotes .
T20425 3400-3403 NNP denotes Fig
T20424 3399-3400 -LRB- denotes (
T20423 3393-3398 NN denotes death
T20422 3388-3392 NN denotes cell
T20421 3385-3387 CC denotes or
T20420 3374-3384 NN denotes production
T20419 3369-3373 JJ denotes TNFα
T20418 3366-3368 IN denotes in
T20417 3356-3365 NN denotes reduction
T20416 3354-3355 DT denotes a
T20415 3351-3353 TO denotes to
T20414 3346-3350 VBP denotes lead
T20413 3344-3345 , denotes ,
T20412 3337-3344 RB denotes however
T20411 3335-3336 , denotes ,
T20410 3332-3335 RB denotes not
T20409 3328-3331 VBD denotes did
T20408 3325-3327 PRP denotes It
T20407 3323-3324 . denotes .
T20406 3318-3323 NN denotes model
T20405 3314-3317 PRP$ denotes our
T20403 3300-3308 VBG denotes agreeing
T20402 3298-3299 , denotes ,
T20401 3297-3298 -RRB- denotes )
T20400 3296-3297 NNP denotes E
T20399 3295-3296 , denotes ,
T20398 3291-3295 CD denotes S10B
T20397 3289-3290 . denotes .
T20396 3286-3289 NNP denotes Fig
T20395 3285-3286 -LRB- denotes (
T20394 3279-3284 NNP denotes Ser63
T20393 3276-3278 IN denotes at
T20392 3270-3275 NN denotes c-Jun
T20391 3267-3269 IN denotes of
T20390 3251-3266 NN denotes phosphorylation
T20389 3247-3250 DT denotes the
T20388 3236-3246 VBG denotes inhibiting
T20387 3230-3235 IN denotes while
T20386 3223-3229 NNP denotes Thr308
T20385 3220-3222 IN denotes on
T20384 3216-3219 NNP denotes Akt
T20383 3213-3215 IN denotes of
T20382 3197-3212 NN denotes phosphorylation
T20381 3189-3196 VBN denotes allowed
T20380 3182-3188 NN denotes JNK1/2
T20379 3179-3181 IN denotes of
T20378 3169-3178 NN denotes knockdown
T20377 3166-3168 CC denotes or
T20376 3155-3165 NN denotes inhibition
T20375 3146-3154 JJ denotes specific
T20374 3144-3145 , denotes ,
T20373 3136-3144 VBN denotes expected
T20372 3133-3135 IN denotes As
T20371 3131-3132 . denotes .
T20370 3130-3131 -RRB- denotes )
T20369 3129-3130 NNP denotes G
T20368 3124-3128 CD denotes S10B
T20367 3122-3123 . denotes .
T20320 2894-2899 JJ denotes basal
T20319 2886-2893 VB denotes inhibit
T20318 2880-2885 MD denotes could
T20317 2872-2879 NNS denotes effects
T20316 2861-2871 JJ denotes off-target
T20315 2855-2860 DT denotes these
T20314 2852-2854 IN denotes of
T20313 2847-2851 DT denotes Both
T20312 2845-2846 . denotes .
T20311 2844-2845 NNP denotes ]
T20310 2842-2844 CD denotes 42
T20309 2841-2842 NNP denotes [
T20308 2836-2840 NNP denotes PDK1
T20307 2832-2835 CC denotes and
T20306 2830-2831 NNP denotes ]
T20305 2828-2830 CD denotes 41
T20304 2827-2828 NNP denotes [
T20303 2822-2826 NNP denotes PI3K
T20302 2819-2821 IN denotes of
T20301 2811-2818 NN denotes subunit
T20300 2805-2810 JJ denotes p110δ
T20299 2801-2804 DT denotes the
T20298 2793-2800 VB denotes inhibit
T20297 2789-2792 MD denotes may
T20296 2784-2788 WDT denotes that
T20295 2774-2783 NN denotes inhibitor
T20294 2761-2773 JJ denotes non-specific
T20293 2752-2760 RB denotes somewhat
T20292 2750-2751 DT denotes a
T20291 2747-2749 VBZ denotes is
T20290 2738-2746 CD denotes SP600125
T20289 2733-2737 IN denotes that
T20288 2723-2732 VBN denotes published
T20287 2718-2722 VBN denotes been
T20286 2714-2717 VBZ denotes has
T20285 2711-2713 PRP denotes It
T20284 2709-2710 . denotes .
T20283 2708-2709 -RRB- denotes )
T20282 2704-2708 CD denotes S10B
T20281 2702-2703 . denotes .
T20280 2699-2702 NNP denotes Fig
T20279 2698-2699 -LRB- denotes (
T20278 2691-2697 NNP denotes Thr308
T20277 2687-2690 CC denotes and
T20276 2680-2686 NNP denotes Ser473
T20275 2675-2679 DT denotes both
T20274 2672-2674 IN denotes at
T20273 2668-2671 NNP denotes Akt
T20272 2665-2667 IN denotes of
T20271 2658-2664 NNS denotes levels
T20270 2642-2657 NN denotes phosphorylation
T20269 2627-2641 JJ denotes post-treatment
T20268 2623-2626 CC denotes and
T20267 2617-2622 JJ denotes basal
T20266 2612-2616 DT denotes both
T20265 2602-2611 VBN denotes inhibited
T20264 2600-2601 , denotes ,
T20263 2599-2600 -RRB- denotes )
T20262 2595-2599 NNP denotes S10A
T20261 2591-2594 NNP denotes S2A
T20260 2589-2590 NNP denotes B
T20259 2588-2589 , denotes ,
T20258 2586-2588 NNP denotes 2A
T20257 2581-2585 NNP denotes Fig.
T20256 2580-2581 -LRB- denotes (
T20255 2569-2579 NN denotes production
T20254 2564-2568 NNP denotes TNFα
T20253 2554-2563 VBD denotes inhibited
T20252 2550-2553 CC denotes and
T20251 2544-2549 NN denotes death
T20250 2539-2543 IN denotes from
T20249 2533-2538 NNS denotes cells
T20248 2528-2532 CD denotes L929
T20247 2518-2527 VBD denotes protected
T20246 2512-2517 WDT denotes which
T20245 2510-2511 , denotes ,
T20244 2502-2510 CD denotes SP600125
T20243 2497-2501 IN denotes that
T20242 2491-2496 VBD denotes found
T20241 2488-2490 PRP denotes we
T20240 2486-2487 , denotes ,
T20239 2479-2486 RB denotes However
T20238 2477-2478 . denotes .
T20237 2474-2477 NNP denotes JNK
T20236 2472-2473 , denotes ,
T20235 2465-2472 NN denotes pathway
T20234 2461-2464 DT denotes the
T20233 2458-2460 IN denotes in
T20232 2451-2457 NN denotes kinase
T20231 2440-2450 JJ denotes downstream
T20230 2438-2439 DT denotes a
T20229 2435-2437 IN denotes of
T20228 2424-2434 NN denotes inhibition
T20227 2418-2423 IN denotes after
T20226 2402-2417 NN denotes phosphorylation
T20225 2398-2401 NNP denotes Akt
T20224 2389-2397 VBD denotes examined
T20223 2386-2388 PRP denotes we
T20222 2384-2385 , denotes ,
T20221 2379-2384 NN denotes model
T20220 2375-2378 PRP$ denotes our
T20219 2370-2374 NN denotes test
T20218 2362-2369 JJ denotes further
T20217 2359-2361 TO denotes to
T20216 2353-2358 NN denotes order
T20215 2350-2352 IN denotes In
T20214 2348-2349 . denotes .
T20213 2347-2348 NNP denotes ]
T20212 2345-2347 CD denotes 15
T20211 2344-2345 NNP denotes [
T20210 2338-2343 NNS denotes cells
T20209 2333-2337 NNP denotes L929
T20208 2330-2332 IN denotes in
T20207 2318-2329 NN denotes necroptosis
T20206 2315-2317 IN denotes in
T20205 2309-2314 NN denotes event
T20204 2300-2308 JJ denotes critical
T20203 2298-2299 DT denotes a
T20202 2296-2297 , denotes ,
T20201 2287-2296 NN denotes synthesis
T20200 2282-2286 NNP denotes TNFα
T20199 2272-2281 NN denotes autocrine
T20198 2268-2271 CC denotes and
T20197 2257-2267 NN denotes activation
T20196 2253-2256 NNP denotes JNK
T20195 2251-2252 , denotes ,
T20194 2245-2251 RB denotes namely
T20193 2243-2244 , denotes ,
T20192 2238-2243 NNS denotes cells
T20191 2233-2237 NNP denotes L929
T20190 2221-2232 JJ denotes necroptotic
T20189 2218-2220 IN denotes in
T20188 2211-2217 NNS denotes events
T20187 2201-2210 NN denotes execution
T20186 2197-2200 CC denotes and
T20185 2187-2196 VBG denotes signaling
T20184 2176-2186 JJ denotes downstream
T20183 2170-2175 VBN denotes known
T20182 2167-2169 TO denotes to
T20181 2160-2166 NN denotes kinase
T20180 2155-2159 CD denotes RIP1
T20179 2144-2154 VBG denotes connecting
T20178 2139-2143 NN denotes link
T20177 2131-2138 JJ denotes pivotal
T20176 2129-2130 DT denotes a
T20175 2120-2128 VBZ denotes provides
T20174 2109-2119 NN denotes activation
T20173 2105-2108 NNP denotes Akt
T20172 2100-2104 IN denotes that
T20171 2090-2099 VBD denotes suggested
T20170 2085-2089 NNS denotes data
T20169 2081-2084 PRP$ denotes our
T20168 2079-2080 , denotes ,
T20167 2073-2079 NNP denotes Second
T20166 2071-2072 . denotes .
T20165 2066-2071 NN denotes death
T20164 2061-2065 NN denotes cell
T20163 2058-2060 TO denotes to
T20162 2046-2057 VBZ denotes contributes
T20161 2044-2045 , denotes ,
T20160 2040-2044 NN denotes turn
T20159 2037-2039 IN denotes in
T20158 2035-2036 , denotes ,
T20157 2030-2035 WDT denotes which
T20156 2028-2029 , denotes ,
T20155 2021-2028 NN denotes pathway
T20154 2014-2020 NNP denotes mTORC1
T20153 2010-2013 DT denotes the
T20152 2007-2009 IN denotes as
T20151 2002-2006 JJ denotes such
T20150 1993-2001 NNS denotes pathways
T20149 1984-1992 NN denotes effector
T20148 1980-1983 NNP denotes Akt
T20147 1976-1979 CC denotes and
T20146 1965-1975 NNS denotes substrates
T20145 1959-1964 VBN denotes known
T20144 1956-1958 IN denotes of
T20143 1949-1955 NN denotes number
T20142 1947-1948 DT denotes a
T20141 1939-1946 IN denotes towards
T20140 1930-1938 NN denotes activity
T20139 1926-1929 PRP$ denotes its
T20138 1917-1925 VB denotes increase
T20137 1914-1916 TO denotes to
T20136 1903-1913 JJ denotes sufficient
T20135 1900-1902 VBZ denotes is
T20134 1896-1899 NNP denotes Akt
T20133 1893-1895 IN denotes of
T20132 1886-1892 CD denotes Thr308
T20131 1883-1885 IN denotes of
T20594 4236-4246 NN denotes conclusion
T20593 4226-4235 JJ denotes important
T20592 4222-4225 CC denotes but
T20591 4220-4221 , denotes ,
T20590 4210-4220 JJ denotes unexpected
T20589 4207-4209 DT denotes an
T20588 4204-4206 TO denotes to
T20587 4201-4203 PRP denotes us
T20586 4197-4200 VBD denotes led
T20585 4192-4196 NNS denotes data
T20584 4188-4191 JJ denotes new
T20583 4182-4187 DT denotes These
T20130 1867-1882 NN denotes phosphorylation
T20129 1855-1866 JJ denotes necroptotic
T20128 1845-1854 JJ denotes selective
T20127 1840-1844 IN denotes that
T20126 1827-1839 VBD denotes demonstrated
T20125 1824-1826 PRP denotes we
T20124 1822-1823 , denotes ,
T20123 1817-1822 RB denotes First
T20122 1815-1816 . denotes .
T20121 1804-1815 NN denotes necroptosis
T20120 1801-1803 TO denotes to
T20119 1790-1800 VBP denotes contribute
T20118 1785-1789 WDT denotes that
T20117 1776-1784 NNS denotes pathways
T20116 1762-1775 JJ denotes Akt-dependent
T20115 1751-1761 JJ denotes downstream
T20114 1738-1750 VBD denotes investigated
T20113 1733-1737 RB denotes also
T20112 1730-1732 PRP denotes We
T20111 1728-1729 . denotes .
T20110 1723-1728 NNS denotes cells
T20109 1718-1722 CD denotes L929
T20108 1715-1717 IN denotes in
T20107 1709-1714 NN denotes death
T20106 1704-1708 NN denotes cell
T20105 1701-1703 IN denotes of
T19924 144-149 VBG denotes using
T19923 135-143 NNS denotes pathways
T19922 125-134 VBG denotes signaling
T19921 108-124 JJ denotes kinase-dependent
T19920 103-107 NNP denotes RIP1
T19919 90-102 VBD denotes investigated
T19918 87-89 PRP denotes we
T19917 81-86 NN denotes study
T19916 76-80 DT denotes this
T19915 73-75 IN denotes In
T19914 67-72 NNP denotes Cells
T19913 62-66 NNP denotes L929
T19912 50-61 NNP denotes Necroptotic
T19911 47-49 IN denotes in
T19910 37-46 VBG denotes Signaling
T19909 27-36 NNP denotes Dependent
T19908 23-26 NNP denotes JNK
T19907 19-22 CC denotes and
T19906 15-18 NNP denotes Akt
T19905 13-14 , denotes ,
T19904 9-13 NNP denotes RIP1
T19903 6-8 IN denotes of
T19902 0-5 NNP denotes Model
T20366 3119-3122 NNP denotes Fig
T20365 3118-3119 -LRB- denotes (
T20364 3113-3117 NNP denotes JNK2
T20363 3109-3112 CC denotes and
T20362 3104-3108 NNP denotes JNK1
T20361 3096-3103 IN denotes against
T20360 3089-3095 NNS denotes siRNAs
T20359 3085-3088 CC denotes and
T20358 3083-3084 , denotes ,
T20357 3082-3083 NNP denotes ]
T20356 3080-3082 CD denotes 43
T20355 3079-3080 NNP denotes [
T20354 3074-3078 NNP denotes VIII
T20353 3064-3073 NN denotes inhibitor
T20352 3060-3063 NNP denotes JNK
T20351 3058-3059 , denotes ,
T20350 3049-3058 NN denotes inhibitor
T20349 3045-3048 NNP denotes JNK
T20348 3036-3044 JJ denotes specific
T20347 3031-3035 RBR denotes more
T20346 3029-3030 DT denotes a
T20345 3026-3028 TO denotes to
T20344 3017-3025 VBD denotes switched
T20343 3014-3016 PRP denotes we
T20342 3012-3013 , denotes ,
T20341 3009-3012 NNP denotes JNK
T20340 3006-3008 IN denotes of
T20339 3001-3005 NN denotes role
T20338 2997-3000 DT denotes the
T20337 2989-2996 VB denotes examine
T20336 2986-2988 TO denotes to
T20335 2984-2985 , denotes ,
T20334 2975-2984 RB denotes Therefore
T20333 2973-2974 . denotes .
T20332 2967-2973 NN denotes system
T20331 2962-2966 DT denotes this
T20330 2959-2961 IN denotes in
T20329 2950-2958 CD denotes SP600125
T20328 2947-2949 IN denotes of
T20327 2943-2946 NN denotes use
T20326 2939-2942 DT denotes the
T20325 2928-2938 VBG denotes precluding
T20324 2926-2927 , denotes ,
T20323 2920-2926 NNS denotes levels
T20322 2904-2919 NN denotes phosphorylation
T20321 2900-2903 NNP denotes Akt
T20104 1696-1700 NN denotes form
T20103 1691-1695 DT denotes this
T20102 1687-1690 IN denotes for
T20101 1673-1686 JJ denotes indispensable
T20100 1670-1672 VBZ denotes is
T20099 1666-1669 NNP denotes Akt
T20098 1663-1665 IN denotes of
T20097 1652-1662 NN denotes activation
T20096 1640-1651 JJ denotes necroptotic
T20095 1635-1639 IN denotes that
T20094 1628-1634 VBD denotes showed
T20093 1625-1627 PRP denotes we
T20092 1623-1624 , denotes ,
T20091 1616-1623 NNS denotes mutants
T20090 1612-1615 NNP denotes Akt
T20089 1609-1611 IN denotes of
T20088 1598-1608 NN denotes expression
T20087 1594-1597 DT denotes the
T20086 1590-1593 CC denotes and
T20085 1588-1589 , denotes ,
T20084 1580-1588 VBZ denotes isoforms
T20083 1576-1579 NNP denotes Akt
T20082 1573-1575 IN denotes of
T20081 1563-1572 NN denotes knockdown
T20080 1561-1562 , denotes ,
T20079 1551-1561 NNS denotes inhibitors
T20078 1547-1550 NNP denotes Akt
T20077 1541-1546 VBG denotes Using
T20076 1068-1069 . denotes .
T20075 1062-1068 NN denotes signal
T20074 1050-1061 JJ denotes necroptotic
T20073 1046-1049 DT denotes the
T20072 1043-1045 IN denotes of
T20071 1031-1042 NN denotes propagation
T20070 1027-1030 DT denotes the
T20069 1023-1026 IN denotes for
T20068 1013-1022 JJ denotes essential
T20067 1010-1012 VBZ denotes is
T20066 1006-1009 CC denotes and
T20065 995-1005 NN denotes inhibition
T20064 987-994 VB denotes caspase
T20063 984-986 TO denotes to
T20062 975-983 NN denotes response
T20061 972-974 IN denotes in
T20060 968-971 NNP denotes Akt
T20059 965-967 IN denotes of
T20058 949-964 NN denotes phosphorylation
T20057 942-948 NNP denotes Thr308
T20056 938-941 IN denotes for
T20055 929-937 VBN denotes required
T20054 926-928 VBZ denotes is
T20053 920-925 NN denotes input
T20052 903-919 JJ denotes kinase-dependent
T20051 898-902 JJ denotes RIP1
T20050 896-897 , denotes ,
T20049 890-896 JJ denotes second
T20048 888-889 DT denotes A
T20047 886-887 . denotes .
T20046 875-886 NN denotes necroptosis
T20045 872-874 IN denotes of
T20044 862-871 NN denotes induction
T20043 858-861 DT denotes the
T20042 854-857 IN denotes for
T20041 843-853 JJ denotes sufficient
T20040 839-842 RB denotes not
T20039 836-838 VBZ denotes is
T20038 830-835 RB denotes alone
T20037 822-829 NNP denotes Myr-Akt
T20036 819-821 IN denotes of
T20035 808-818 NN denotes expression
T20034 806-807 , denotes ,
T20033 802-806 NN denotes time
T20032 797-801 JJ denotes same
T20031 793-796 DT denotes the
T20030 790-792 IN denotes At
T20029 788-789 . denotes .
T20028 781-788 NNS denotes factors
T20027 774-780 NN denotes growth
T20026 770-773 IN denotes for
T20025 758-769 NN denotes requirement
T20024 754-757 DT denotes the
T20023 744-753 VBZ denotes overcomes
T20022 742-743 , denotes ,
T20021 735-742 NNP denotes Myr-Akt
T20020 733-734 , denotes ,
T20019 724-733 VBP denotes construct
T20018 720-723 NNP denotes Akt
T20017 702-719 JJ denotes membrane-targeted
T20016 687-701 RB denotes constitutively
T20015 685-686 DT denotes a
T20014 682-684 IN denotes of
T20013 671-681 NN denotes Expression
T20012 669-670 . denotes .
T20011 666-669 NNP denotes Akt
T20010 663-665 IN denotes of
T20009 650-662 NN denotes localization
T20008 641-649 NN denotes membrane
T20007 634-640 NN denotes plasma
T20006 630-633 DT denotes the
T20005 627-629 TO denotes to
T20004 621-626 VBZ denotes leads
T20003 619-620 , denotes ,
T20002 612-619 NNS denotes factors
T20001 605-611 NN denotes growth
T20000 602-604 IN denotes by
T19999 594-601 VBN denotes induced
T19998 591-593 VBZ denotes is
T19997 585-590 WDT denotes which
T19996 583-584 , denotes ,
T19995 578-583 NN denotes input
T19994 572-577 JJ denotes first
T19993 568-571 DT denotes The
T19992 566-567 . denotes .
T19991 559-566 NNS denotes signals
T19990 550-558 JJ denotes distinct
T19989 546-549 CD denotes two
T19988 537-545 VBZ denotes requires
T19987 533-536 NNP denotes Akt
T19986 530-532 IN denotes of
T19985 514-529 NN denotes phosphorylation
T19984 491-513 JJ denotes necroptosis-associated
T19983 489-490 , denotes ,
T19982 488-489 -RRB- denotes )
T19981 487-488 CD denotes 9
T19980 482-486 FW denotes Fig.
T19979 481-482 -LRB- denotes (
T19978 475-480 NN denotes model
T19977 471-474 PRP$ denotes our
T19976 468-470 TO denotes to
T19975 458-467 VBG denotes According
T19974 456-457 . denotes .
T19973 450-456 JJ denotes Ser473
T19972 446-449 RB denotes not
T19971 442-445 CC denotes but
T19970 440-441 , denotes ,
T19969 434-440 NNP denotes Thr308
T19968 431-433 IN denotes on
T19967 415-430 NN denotes phosphorylation
T19966 411-414 PRP$ denotes its
T19965 408-410 IN denotes in
T19964 399-407 NN denotes increase
T19963 389-398 JJ denotes selective
T19962 387-388 DT denotes a
T19961 384-386 TO denotes to
T19960 378-383 VBZ denotes leads
T19959 372-377 WDT denotes which
T19958 370-371 , denotes ,
T19957 364-370 NN denotes kinase
T19956 359-363 CD denotes RIP1
T19955 354-358 IN denotes from
T19954 343-353 JJ denotes downstream
T19953 333-342 VBG denotes signaling
T19952 330-332 IN denotes in
T19951 322-329 VBN denotes engaged
T19950 309-321 RB denotes specifically
T19949 306-308 VBZ denotes is
T19948 299-305 NN denotes kinase
T19947 295-298 NNP denotes Akt
T19946 290-294 IN denotes that
T19945 282-289 VBP denotes suggest
T19944 274-281 NNS denotes results
T19943 270-273 PRP$ denotes our
T19942 268-269 , denotes ,
T19941 258-268 RB denotes Altogether
T19940 256-257 . denotes .
T19939 248-256 NNP denotes zVAD.fmk
T19938 238-247 NN denotes inhibitor
T19937 226-237 NN denotes pan-caspase
T19936 222-225 DT denotes the
T19935 217-221 IN denotes with
T19934 209-216 VBN denotes treated
T19933 204-208 WRB denotes when
T19932 192-203 NN denotes necroptosis
T19931 189-191 IN denotes by
T19930 185-188 VBP denotes die
T19929 180-184 WDT denotes that
T19928 174-179 NNS denotes cells
T19927 169-173 NNP denotes L929
T19926 156-168 NN denotes fibrosarcoma
T19925 150-155 NN denotes mouse
R13153 T19902 T19902 ROOT Model,Model
R13154 T19903 T19902 prep of,Model
R13155 T19904 T19903 pobj RIP1,of
R13156 T19905 T19904 punct ",",RIP1
R13157 T19906 T19904 conj Akt,RIP1
R13158 T19907 T19906 cc and,Akt
R13159 T19908 T19909 compound JNK,Dependent
R13160 T19909 T19906 conj Dependent,Akt
R13161 T19910 T19910 ROOT Signaling,Signaling
R13162 T19911 T19910 prep in,Signaling
R13163 T19912 T19914 compound Necroptotic,Cells
R13164 T19913 T19914 compound L929,Cells
R13165 T19914 T19911 pobj Cells,in
R13166 T19915 T19919 prep In,investigated
R13167 T19916 T19917 det this,study
R13168 T19917 T19915 pobj study,In
R13169 T19918 T19919 nsubj we,investigated
R13170 T19919 T19919 ROOT investigated,investigated
R13171 T19920 T19923 nmod RIP1,pathways
R13172 T19921 T19923 amod kinase-dependent,pathways
R13173 T19922 T19923 compound signaling,pathways
R13174 T19923 T19919 dobj pathways,investigated
R13175 T19924 T19919 advcl using,investigated
R13176 T19925 T19928 compound mouse,cells
R13177 T19926 T19927 compound fibrosarcoma,L929
R13178 T19927 T19928 compound L929,cells
R13179 T19928 T19924 dobj cells,using
R13180 T19929 T19930 nsubj that,die
R13181 T19930 T19928 relcl die,cells
R13182 T19931 T19930 prep by,die
R13183 T19932 T19931 pobj necroptosis,by
R13184 T19933 T19934 advmod when,treated
R13185 T19934 T19930 advcl treated,die
R13186 T19935 T19934 prep with,treated
R13187 T19936 T19938 det the,inhibitor
R13188 T19937 T19938 compound pan-caspase,inhibitor
R13189 T19938 T19935 pobj inhibitor,with
R13190 T19939 T19938 appos zVAD.fmk,inhibitor
R13191 T19940 T19919 punct .,investigated
R13192 T19941 T19945 advmod Altogether,suggest
R13193 T19942 T19945 punct ",",suggest
R13194 T19943 T19944 poss our,results
R13195 T19944 T19945 nsubj results,suggest
R13196 T19945 T19945 ROOT suggest,suggest
R13197 T19946 T19951 mark that,engaged
R13198 T19947 T19948 compound Akt,kinase
R13199 T19948 T19951 nsubjpass kinase,engaged
R13200 T19949 T19951 auxpass is,engaged
R13201 T19950 T19951 advmod specifically,engaged
R13202 T19951 T19945 ccomp engaged,suggest
R13203 T19952 T19951 prep in,engaged
R13204 T19953 T19952 pcomp signaling,in
R13205 T19954 T19953 dobj downstream,signaling
R13206 T19955 T19953 prep from,signaling
R13207 T19956 T19957 nummod RIP1,kinase
R13208 T19957 T19955 pobj kinase,from
R13209 T19958 T19957 punct ",",kinase
R13210 T19959 T19960 nsubj which,leads
R13211 T19960 T19957 relcl leads,kinase
R13212 T19961 T19960 prep to,leads
R13213 T19962 T19964 det a,increase
R13214 T19963 T19964 amod selective,increase
R13215 T19964 T19961 pobj increase,to
R13216 T19965 T19964 prep in,increase
R13217 T19966 T19967 poss its,phosphorylation
R13218 T19967 T19965 pobj phosphorylation,in
R13219 T19968 T19967 prep on,phosphorylation
R13220 T19969 T19968 pobj Thr308,on
R13221 T19970 T19964 punct ",",increase
R13222 T19971 T19964 cc but,increase
R13223 T19972 T19973 neg not,Ser473
R13224 T19973 T19964 conj Ser473,increase
R13225 T19974 T19945 punct .,suggest
R13226 T19975 T19988 prep According,requires
R13227 T19976 T19975 prep to,According
R13228 T19977 T19978 poss our,model
R13229 T19978 T19976 pobj model,to
R13230 T19979 T19980 punct (,Fig.
R13231 T19980 T19981 nmod Fig.,9
R13232 T19981 T19978 appos 9,model
R13233 T19982 T19975 punct ),According
R13234 T19983 T19988 punct ",",requires
R13235 T19984 T19985 amod necroptosis-associated,phosphorylation
R13236 T19985 T19988 nsubj phosphorylation,requires
R13237 T19986 T19985 prep of,phosphorylation
R13238 T19987 T19986 pobj Akt,of
R13239 T19988 T19988 ROOT requires,requires
R13240 T19989 T19991 nummod two,signals
R13241 T19990 T19991 amod distinct,signals
R13242 T19991 T19988 dobj signals,requires
R13243 T19992 T19988 punct .,requires
R13244 T19993 T19995 det The,input
R13245 T19994 T19995 amod first,input
R13246 T19995 T20004 nsubj input,leads
R13247 T19996 T19995 punct ",",input
R13248 T19997 T19999 nsubjpass which,induced
R13249 T19998 T19999 auxpass is,induced
R13250 T19999 T19995 relcl induced,input
R13251 T20000 T19999 agent by,induced
R13252 T20001 T20002 compound growth,factors
R13253 T20002 T20000 pobj factors,by
R13254 T20003 T19995 punct ",",input
R13255 T20004 T20004 ROOT leads,leads
R13256 T20005 T20004 prep to,leads
R13257 T20006 T20009 det the,localization
R13258 T20007 T20008 compound plasma,membrane
R13259 T20008 T20009 compound membrane,localization
R13260 T20009 T20005 pobj localization,to
R13261 T20010 T20009 prep of,localization
R13262 T20011 T20010 pobj Akt,of
R13263 T20012 T20004 punct .,leads
R13264 T20013 T20019 nsubj Expression,construct
R13265 T20014 T20013 prep of,Expression
R13266 T20015 T20018 det a,Akt
R13267 T20016 T20017 advmod constitutively,membrane-targeted
R13268 T20017 T20018 amod membrane-targeted,Akt
R13269 T20018 T20014 pobj Akt,of
R13270 T20019 T20023 ccomp construct,overcomes
R13271 T20020 T20019 punct ",",construct
R13272 T20021 T20023 nsubj Myr-Akt,overcomes
R13273 T20022 T20023 punct ",",overcomes
R13274 T20023 T20023 ROOT overcomes,overcomes
R13275 T20024 T20025 det the,requirement
R13276 T20025 T20023 dobj requirement,overcomes
R13277 T20026 T20025 prep for,requirement
R13278 T20027 T20028 compound growth,factors
R13279 T20028 T20026 pobj factors,for
R13280 T20029 T20023 punct .,overcomes
R13281 T20030 T20039 prep At,is
R13282 T20031 T20033 det the,time
R13283 T20032 T20033 amod same,time
R13284 T20033 T20030 pobj time,At
R13285 T20034 T20039 punct ",",is
R13286 T20035 T20039 nsubj expression,is
R13287 T20036 T20035 prep of,expression
R13288 T20037 T20036 pobj Myr-Akt,of
R13289 T20038 T20035 advmod alone,expression
R13290 T20039 T20039 ROOT is,is
R13291 T20040 T20039 neg not,is
R13292 T20041 T20039 acomp sufficient,is
R13293 T20042 T20041 prep for,sufficient
R13294 T20043 T20044 det the,induction
R13295 T20044 T20042 pobj induction,for
R13296 T20045 T20044 prep of,induction
R13297 T20046 T20045 pobj necroptosis,of
R13298 T20047 T20039 punct .,is
R13299 T20048 T20053 det A,input
R13300 T20049 T20053 amod second,input
R13301 T20050 T20053 punct ",",input
R13302 T20051 T20053 amod RIP1,input
R13303 T20052 T20053 amod kinase-dependent,input
R13304 T20053 T20055 nsubjpass input,required
R13305 T20054 T20055 auxpass is,required
R13306 T20055 T20055 ROOT required,required
R13307 T20056 T20055 prep for,required
R13308 T20057 T20058 compound Thr308,phosphorylation
R13309 T20058 T20056 pobj phosphorylation,for
R13310 T20059 T20058 prep of,phosphorylation
R13311 T20060 T20059 pobj Akt,of
R13312 T20061 T20055 prep in,required
R13313 T20062 T20061 pobj response,in
R13314 T20063 T20062 prep to,response
R13315 T20064 T20063 pobj caspase,to
R13316 T20065 T20064 dobj inhibition,caspase
R13317 T20066 T20055 cc and,required
R13318 T20067 T20055 conj is,required
R13319 T20068 T20067 acomp essential,is
R13320 T20069 T20067 prep for,is
R13321 T20070 T20071 det the,propagation
R13322 T20071 T20069 pobj propagation,for
R13323 T20072 T20071 prep of,propagation
R13324 T20073 T20075 det the,signal
R13325 T20074 T20075 amod necroptotic,signal
R13326 T20075 T20072 pobj signal,of
R13327 T20076 T20055 punct .,required
R13328 T20077 T20094 advcl Using,showed
R13329 T20078 T20079 compound Akt,inhibitors
R13330 T20079 T20077 dobj inhibitors,Using
R13331 T20080 T20079 punct ",",inhibitors
R13332 T20081 T20079 appos knockdown,inhibitors
R13333 T20082 T20081 prep of,knockdown
R13334 T20083 T20084 compound Akt,isoforms
R13335 T20084 T20082 pobj isoforms,of
R13336 T20085 T20081 punct ",",knockdown
R13337 T20086 T20081 cc and,knockdown
R13338 T20087 T20088 det the,expression
R13339 T20088 T20081 conj expression,knockdown
R13340 T20089 T20088 prep of,expression
R13341 T20090 T20091 compound Akt,mutants
R13342 T20091 T20089 pobj mutants,of
R13343 T20092 T20094 punct ",",showed
R13344 T20093 T20094 nsubj we,showed
R13345 T20094 T20094 ROOT showed,showed
R13346 T20095 T20100 mark that,is
R13347 T20096 T20097 amod necroptotic,activation
R13348 T20097 T20100 nsubj activation,is
R13349 T20098 T20097 prep of,activation
R13350 T20099 T20098 pobj Akt,of
R13351 T20100 T20094 ccomp is,showed
R13352 T20101 T20100 acomp indispensable,is
R13353 T20102 T20101 prep for,indispensable
R13354 T20103 T20104 det this,form
R13355 T20104 T20102 pobj form,for
R13356 T20105 T20104 prep of,form
R13357 T20106 T20107 compound cell,death
R13358 T20107 T20105 pobj death,of
R13359 T20108 T20100 prep in,is
R13360 T20109 T20110 nummod L929,cells
R13361 T20110 T20108 pobj cells,in
R13362 T20111 T20094 punct .,showed
R13363 T20112 T20114 nsubj We,investigated
R13364 T20113 T20114 advmod also,investigated
R13365 T20114 T20114 ROOT investigated,investigated
R13366 T20115 T20117 amod downstream,pathways
R13367 T20116 T20117 amod Akt-dependent,pathways
R13368 T20117 T20114 dobj pathways,investigated
R13369 T20118 T20119 nsubj that,contribute
R13370 T20119 T20117 relcl contribute,pathways
R13371 T20120 T20121 aux to,necroptosis
R13372 T20121 T20119 xcomp necroptosis,contribute
R13373 T20122 T20114 punct .,investigated
R13374 T20123 T20126 advmod First,demonstrated
R13375 T20124 T20126 punct ",",demonstrated
R13376 T20125 T20126 nsubj we,demonstrated
R13377 T20126 T20126 ROOT demonstrated,demonstrated
R13378 T20127 T20135 mark that,is
R13379 T20128 T20130 amod selective,phosphorylation
R13380 T20129 T20130 amod necroptotic,phosphorylation
R13381 T20130 T20135 nsubj phosphorylation,is
R13382 T20131 T20130 prep of,phosphorylation
R13383 T20132 T20131 pobj Thr308,of
R13384 T20133 T20132 prep of,Thr308
R13385 T20134 T20133 pobj Akt,of
R13386 T20135 T20126 ccomp is,demonstrated
R13387 T20136 T20135 acomp sufficient,is
R13388 T20137 T20138 aux to,increase
R13389 T20138 T20136 xcomp increase,sufficient
R13390 T20139 T20140 poss its,activity
R13391 T20140 T20138 dobj activity,increase
R13392 T20141 T20138 prep towards,increase
R13393 T20142 T20143 det a,number
R13394 T20143 T20141 pobj number,towards
R13395 T20144 T20143 prep of,number
R13396 T20145 T20146 amod known,substrates
R13397 T20146 T20144 pobj substrates,of
R13398 T20147 T20146 cc and,substrates
R13399 T20148 T20150 nmod Akt,pathways
R13400 T20149 T20150 compound effector,pathways
R13401 T20150 T20146 conj pathways,substrates
R13402 T20151 T20152 amod such,as
R13403 T20152 T20150 prep as,pathways
R13404 T20153 T20155 det the,pathway
R13405 T20154 T20155 compound mTORC1,pathway
R13406 T20155 T20152 pobj pathway,as
R13407 T20156 T20155 punct ",",pathway
R13408 T20157 T20162 nsubj which,contributes
R13409 T20158 T20162 punct ",",contributes
R13410 T20159 T20162 prep in,contributes
R13411 T20160 T20159 pobj turn,in
R13412 T20161 T20162 punct ",",contributes
R13413 T20162 T20143 relcl contributes,number
R13414 T20163 T20162 prep to,contributes
R13415 T20164 T20165 compound cell,death
R13416 T20165 T20163 pobj death,to
R13417 T20166 T20126 punct .,demonstrated
R13418 T20167 T20171 advmod Second,suggested
R13419 T20168 T20171 punct ",",suggested
R13420 T20169 T20170 poss our,data
R13421 T20170 T20171 nsubj data,suggested
R13422 T20171 T20171 ROOT suggested,suggested
R13423 T20172 T20175 mark that,provides
R13424 T20173 T20174 compound Akt,activation
R13425 T20174 T20175 nsubj activation,provides
R13426 T20175 T20171 ccomp provides,suggested
R13427 T20176 T20178 det a,link
R13428 T20177 T20178 amod pivotal,link
R13429 T20178 T20175 dobj link,provides
R13430 T20179 T20178 acl connecting,link
R13431 T20180 T20181 nummod RIP1,kinase
R13432 T20181 T20179 dobj kinase,connecting
R13433 T20182 T20179 prep to,connecting
R13434 T20183 T20185 amod known,signaling
R13435 T20184 T20185 amod downstream,signaling
R13436 T20185 T20182 pobj signaling,to
R13437 T20186 T20185 cc and,signaling
R13438 T20187 T20188 compound execution,events
R13439 T20188 T20185 conj events,signaling
R13440 T20189 T20188 prep in,events
R13441 T20190 T20192 amod necroptotic,cells
R13442 T20191 T20192 compound L929,cells
R13443 T20192 T20189 pobj cells,in
R13444 T20193 T20192 punct ",",cells
R13445 T20194 T20197 advmod namely,activation
R13446 T20195 T20197 punct ",",activation
R13447 T20196 T20197 compound JNK,activation
R13448 T20197 T20192 conj activation,cells
R13449 T20198 T20197 cc and,activation
R13450 T20199 T20197 conj autocrine,activation
R13451 T20200 T20201 compound TNFα,synthesis
R13452 T20201 T20197 conj synthesis,activation
R13453 T20202 T20197 punct ",",activation
R13454 T20203 T20205 det a,event
R13455 T20204 T20205 amod critical,event
R13456 T20205 T20197 conj event,activation
R13457 T20206 T20205 prep in,event
R13458 T20207 T20206 pobj necroptosis,in
R13459 T20208 T20205 prep in,event
R13460 T20209 T20210 compound L929,cells
R13461 T20210 T20208 pobj cells,in
R13462 T20211 T20213 nmod [,]
R13463 T20212 T20213 nummod 15,]
R13464 T20213 T20205 appos ],event
R13465 T20214 T20171 punct .,suggested
R13466 T20215 T20219 prep In,test
R13467 T20216 T20215 pobj order,In
R13468 T20217 T20219 aux to,test
R13469 T20218 T20219 advmod further,test
R13470 T20219 T20224 advcl test,examined
R13471 T20220 T20221 poss our,model
R13472 T20221 T20219 dobj model,test
R13473 T20222 T20224 punct ",",examined
R13474 T20223 T20224 nsubj we,examined
R13475 T20224 T20224 ROOT examined,examined
R13476 T20225 T20226 compound Akt,phosphorylation
R13477 T20226 T20224 dobj phosphorylation,examined
R13478 T20227 T20224 prep after,examined
R13479 T20228 T20227 pobj inhibition,after
R13480 T20229 T20228 prep of,inhibition
R13481 T20230 T20232 det a,kinase
R13482 T20231 T20232 amod downstream,kinase
R13483 T20232 T20229 pobj kinase,of
R13484 T20233 T20232 prep in,kinase
R13485 T20234 T20235 det the,pathway
R13486 T20235 T20233 pobj pathway,in
R13487 T20236 T20235 punct ",",pathway
R13488 T20237 T20235 appos JNK,pathway
R13489 T20238 T20224 punct .,examined
R13490 T20239 T20242 advmod However,found
R13491 T20240 T20242 punct ",",found
R13492 T20241 T20242 nsubj we,found
R13493 T20242 T20242 ROOT found,found
R13494 T20243 T20242 dobj that,found
R13495 T20244 T20243 nsubj SP600125,that
R13496 T20245 T20244 punct ",",SP600125
R13497 T20246 T20247 nsubj which,protected
R13498 T20247 T20244 relcl protected,SP600125
R13499 T20248 T20249 nummod L929,cells
R13500 T20249 T20247 dobj cells,protected
R13501 T20250 T20247 prep from,protected
R13502 T20251 T20250 pobj death,from
R13503 T20252 T20247 cc and,protected
R13504 T20253 T20247 conj inhibited,protected
R13505 T20254 T20255 compound TNFα,production
R13506 T20255 T20253 dobj production,inhibited
R13507 T20256 T20258 punct (,2A
R13508 T20257 T20258 compound Fig.,2A
R13509 T20258 T20255 appos 2A,production
R13510 T20259 T20258 punct ",",2A
R13511 T20260 T20262 compound B,S10A
R13512 T20261 T20262 compound S2A,S10A
R13513 T20262 T20258 appos S10A,2A
R13514 T20263 T20258 punct ),2A
R13515 T20264 T20253 punct ",",inhibited
R13516 T20265 T20253 conj inhibited,inhibited
R13517 T20266 T20267 preconj both,basal
R13518 T20267 T20271 amod basal,levels
R13519 T20268 T20267 cc and,basal
R13520 T20269 T20267 conj post-treatment,basal
R13521 T20270 T20271 compound phosphorylation,levels
R13522 T20271 T20265 dobj levels,inhibited
R13523 T20272 T20271 prep of,levels
R13524 T20273 T20272 pobj Akt,of
R13525 T20274 T20265 prep at,inhibited
R13526 T20275 T20276 preconj both,Ser473
R13527 T20276 T20274 pobj Ser473,at
R13528 T20277 T20276 cc and,Ser473
R13529 T20278 T20276 conj Thr308,Ser473
R13530 T20279 T20280 punct (,Fig
R13531 T20280 T20278 appos Fig,Thr308
R13532 T20281 T20242 punct .,found
R13533 T20282 T20282 ROOT S10B,S10B
R13534 T20283 T20282 punct ),S10B
R13535 T20284 T20282 punct .,S10B
R13536 T20285 T20288 nsubjpass It,published
R13537 T20286 T20288 aux has,published
R13538 T20287 T20288 auxpass been,published
R13539 T20288 T20288 ROOT published,published
R13540 T20289 T20291 mark that,is
R13541 T20290 T20291 nsubj SP600125,is
R13542 T20291 T20288 ccomp is,published
R13543 T20292 T20295 det a,inhibitor
R13544 T20293 T20294 advmod somewhat,non-specific
R13545 T20294 T20295 amod non-specific,inhibitor
R13546 T20295 T20291 attr inhibitor,is
R13547 T20296 T20298 nsubj that,inhibit
R13548 T20297 T20298 aux may,inhibit
R13549 T20298 T20295 relcl inhibit,inhibitor
R13550 T20299 T20301 det the,subunit
R13551 T20300 T20301 amod p110δ,subunit
R13552 T20301 T20298 dobj subunit,inhibit
R13553 T20302 T20301 prep of,subunit
R13554 T20303 T20304 compound PI3K,[
R13555 T20304 T20302 pobj [,of
R13556 T20305 T20306 nummod 41,]
R13557 T20306 T20301 conj ],subunit
R13558 T20307 T20306 cc and,]
R13559 T20308 T20309 compound PDK1,[
R13560 T20309 T20306 conj [,]
R13561 T20310 T20311 nummod 42,]
R13562 T20311 T20306 conj ],]
R13563 T20312 T20288 punct .,published
R13564 T20313 T20319 nsubj Both,inhibit
R13565 T20314 T20313 prep of,Both
R13566 T20315 T20317 det these,effects
R13567 T20316 T20317 amod off-target,effects
R13568 T20317 T20314 pobj effects,of
R13569 T20318 T20319 aux could,inhibit
R13570 T20319 T20319 ROOT inhibit,inhibit
R13571 T20320 T20323 amod basal,levels
R13572 T20321 T20323 compound Akt,levels
R13573 T20322 T20323 compound phosphorylation,levels
R13574 T20323 T20319 dobj levels,inhibit
R13575 T20324 T20319 punct ",",inhibit
R13576 T20325 T20319 advcl precluding,inhibit
R13577 T20326 T20327 det the,use
R13578 T20327 T20325 dobj use,precluding
R13579 T20328 T20327 prep of,use
R13580 T20329 T20328 pobj SP600125,of
R13581 T20330 T20327 prep in,use
R13582 T20331 T20332 det this,system
R13583 T20332 T20330 pobj system,in
R13584 T20333 T20319 punct .,inhibit
R13585 T20334 T20344 advmod Therefore,switched
R13586 T20335 T20344 punct ",",switched
R13587 T20336 T20337 aux to,examine
R13588 T20337 T20344 advcl examine,switched
R13589 T20338 T20339 det the,role
R13590 T20339 T20337 dobj role,examine
R13591 T20340 T20339 prep of,role
R13592 T20341 T20340 pobj JNK,of
R13593 T20342 T20344 punct ",",switched
R13594 T20343 T20344 nsubj we,switched
R13595 T20344 T20344 ROOT switched,switched
R13596 T20345 T20344 prep to,switched
R13597 T20346 T20350 det a,inhibitor
R13598 T20347 T20348 advmod more,specific
R13599 T20348 T20350 amod specific,inhibitor
R13600 T20349 T20350 compound JNK,inhibitor
R13601 T20350 T20345 pobj inhibitor,to
R13602 T20351 T20344 punct ",",switched
R13603 T20352 T20353 compound JNK,inhibitor
R13604 T20353 T20344 npadvmod inhibitor,switched
R13605 T20354 T20355 compound VIII,[
R13606 T20355 T20353 appos [,inhibitor
R13607 T20356 T20357 nummod 43,]
R13608 T20357 T20353 conj ],inhibitor
R13609 T20358 T20357 punct ",",]
R13610 T20359 T20357 cc and,]
R13611 T20360 T20357 conj siRNAs,]
R13612 T20361 T20360 prep against,siRNAs
R13613 T20362 T20361 pobj JNK1,against
R13614 T20363 T20362 cc and,JNK1
R13615 T20364 T20362 conj JNK2,JNK1
R13616 T20365 T20366 punct (,Fig
R13617 T20366 T20364 appos Fig,JNK2
R13618 T20367 T20344 punct .,switched
R13619 T20368 T20369 nummod S10B,G
R13620 T20369 T20369 ROOT G,G
R13621 T20370 T20369 punct ),G
R13622 T20371 T20369 punct .,G
R13623 T20372 T20373 mark As,expected
R13624 T20373 T20381 advcl expected,allowed
R13625 T20374 T20373 punct ",",expected
R13626 T20375 T20376 amod specific,inhibition
R13627 T20376 T20381 nsubj inhibition,allowed
R13628 T20377 T20376 cc or,inhibition
R13629 T20378 T20376 conj knockdown,inhibition
R13630 T20379 T20376 prep of,inhibition
R13631 T20380 T20379 pobj JNK1/2,of
R13632 T20381 T20381 ROOT allowed,allowed
R13633 T20382 T20381 dobj phosphorylation,allowed
R13634 T20383 T20382 prep of,phosphorylation
R13635 T20384 T20383 pobj Akt,of
R13636 T20385 T20382 prep on,phosphorylation
R13637 T20386 T20385 pobj Thr308,on
R13638 T20387 T20388 mark while,inhibiting
R13639 T20388 T20381 advcl inhibiting,allowed
R13640 T20389 T20390 det the,phosphorylation
R13641 T20390 T20388 dobj phosphorylation,inhibiting
R13642 T20391 T20390 prep of,phosphorylation
R13643 T20392 T20391 pobj c-Jun,of
R13644 T20393 T20388 prep at,inhibiting
R13645 T20394 T20393 pobj Ser63,at
R13646 T20395 T20396 punct (,Fig
R13647 T20396 T20394 appos Fig,Ser63
R13648 T20397 T20381 punct .,allowed
R13649 T20398 T20400 nummod S10B,E
R13650 T20399 T20400 punct ",",E
R13651 T20400 T20400 ROOT E,E
R13652 T20401 T20400 punct ),E
R13653 T20402 T20400 punct ",",E
R13654 T20403 T20400 acl agreeing,E
R13655 T20404 T20403 prep with,agreeing
R13656 T20405 T20406 poss our,model
R13657 T20406 T20404 pobj model,with
R13658 T20407 T20400 punct .,E
R13659 T20408 T20414 nsubj It,lead
R13660 T20409 T20414 aux did,lead
R13661 T20410 T20409 neg not,did
R13662 T20411 T20414 punct ",",lead
R13663 T20412 T20414 advmod however,lead
R13664 T20413 T20414 punct ",",lead
R13665 T20414 T20414 ROOT lead,lead
R13666 T20415 T20414 prep to,lead
R13667 T20416 T20417 det a,reduction
R13668 T20417 T20415 pobj reduction,to
R13669 T20418 T20417 prep in,reduction
R13670 T20419 T20420 amod TNFα,production
R13671 T20420 T20418 pobj production,in
R13672 T20421 T20420 cc or,production
R13673 T20422 T20423 compound cell,death
R13674 T20423 T20420 conj death,production
R13675 T20424 T20420 punct (,production
R13676 T20425 T20417 appos Fig,reduction
R13677 T20426 T20414 punct .,lead
R13678 T20427 T20427 ROOT S10C,S10C
R13679 T20428 T20427 punct ",",S10C
R13680 T20429 T20427 appos D,S10C
R13681 T20430 T20429 punct ",",D
R13682 T20431 T20429 appos F,D
R13683 T20432 T20429 punct ",",D
R13684 T20433 T20429 conj G,D
R13685 T20434 T20429 punct ),D
R13686 T20435 T20427 punct ",",S10C
R13687 T20436 T20427 acl suggesting,S10C
R13688 T20437 T20448 mark that,reflect
R13689 T20438 T20439 amod earlier,data
R13690 T20439 T20448 nsubj data,reflect
R13691 T20440 T20439 prep with,data
R13692 T20441 T20442 nummod SP600125,protection
R13693 T20442 T20440 pobj protection,with
R13694 T20443 T20442 punct (,protection
R13695 T20444 T20442 appos Fig.,protection
R13696 T20445 T20444 appos 2,Fig.
R13697 T20446 T20442 punct ),protection
R13698 T20447 T20448 aux could,reflect
R13699 T20448 T20436 ccomp reflect,suggesting
R13700 T20449 T20450 amod off-target,effects
R13701 T20450 T20448 dobj effects,reflect
R13702 T20451 T20450 prep of,effects
R13703 T20452 T20453 det this,molecule
R13704 T20453 T20451 pobj molecule,of
R13705 T20454 T20450 punct ",",effects
R13706 T20455 T20456 advmod rather,than
R13707 T20456 T20450 cc than,effects
R13708 T20457 T20458 compound JNK,inhibition
R13709 T20458 T20450 conj inhibition,effects
R13710 T20459 T20427 punct .,S10C
R13711 T20460 T20461 amod Previous,reports
R13712 T20461 T20463 nsubj reports,suggested
R13713 T20462 T20463 advmod also,suggested
R13714 T20463 T20463 ROOT suggested,suggested
R13715 T20464 T20466 det a,role
R13716 T20465 T20466 amod critical,role
R13717 T20466 T20463 dobj role,suggested
R13718 T20467 T20466 prep for,role
R13719 T20468 T20467 pobj c-Jun,for
R13720 T20469 T20468 prep in,c-Jun
R13721 T20470 T20469 pobj necroptosis,in
R13722 T20471 T20470 cc and,necroptosis
R13723 T20472 T20473 compound autocrine,TNFα
R13724 T20473 T20474 compound TNFα,synthesis
R13725 T20474 T20466 conj synthesis,role
R13726 T20475 T20477 nmod [,]
R13727 T20476 T20477 nummod 13,]
R13728 T20477 T20474 appos ],synthesis
R13729 T20478 T20477 punct ",",]
R13730 T20479 T20477 conj [,]
R13731 T20480 T20481 nummod 14,]
R13732 T20481 T20477 conj ],]
R13733 T20482 T20481 punct ",",]
R13734 T20483 T20481 conj [,]
R13735 T20484 T20485 nummod 15,]
R13736 T20485 T20481 conj ],]
R13737 T20486 T20463 cc and,suggested
R13738 T20487 T20488 nsubj we,confirmed
R13739 T20488 T20463 conj confirmed,suggested
R13740 T20489 T20490 det these,conclusions
R13741 T20490 T20488 dobj conclusions,confirmed
R13742 T20491 T20488 advcl using,confirmed
R13743 T20492 T20493 amod c-Jun,siRNA
R13744 T20493 T20491 dobj siRNA,using
R13745 T20494 T20493 acl knockdown,siRNA
R13746 T20495 T20496 punct (,Fig
R13747 T20496 T20494 appos Fig,knockdown
R13748 T20497 T20488 punct .,confirmed
R13749 T20498 T20499 nummod S10H,J
R13750 T20499 T20499 ROOT J,J
R13751 T20500 T20499 punct ),J
R13752 T20501 T20499 punct .,J
R13753 T20502 T20511 advmod Notably,reduced
R13754 T20503 T20511 punct ",",reduced
R13755 T20504 T20511 prep in,reduced
R13756 T20505 T20506 det this,case
R13757 T20506 T20504 pobj case,in
R13758 T20507 T20511 punct ",",reduced
R13759 T20508 T20509 compound Thr308,phosphorylation
R13760 T20509 T20511 nsubjpass phosphorylation,reduced
R13761 T20510 T20511 auxpass was,reduced
R13762 T20511 T20511 ROOT reduced,reduced
R13763 T20512 T20511 prep after,reduced
R13764 T20513 T20514 det the,induction
R13765 T20514 T20512 pobj induction,after
R13766 T20515 T20514 prep of,induction
R13767 T20516 T20515 pobj necroptosis,of
R13768 T20517 T20511 punct .,reduced
R13769 T20518 T20529 advmod Thus,create
R13770 T20519 T20529 punct ",",create
R13771 T20520 T20522 nmod autocrine,production
R13772 T20521 T20522 compound TNFα,production
R13773 T20522 T20529 nsubj production,create
R13774 T20523 T20522 punct ",",production
R13775 T20524 T20522 amod dependent,production
R13776 T20525 T20524 prep on,dependent
R13777 T20526 T20525 pobj c-Jun,on
R13778 T20527 T20529 punct ",",create
R13779 T20528 T20529 aux may,create
R13780 T20529 T20529 ROOT create,create
R13781 T20530 T20532 det a,loop
R13782 T20531 T20532 compound feedback,loop
R13783 T20532 T20529 dobj loop,create
R13784 T20533 T20534 nsubj that,contributes
R13785 T20534 T20532 relcl contributes,loop
R13786 T20535 T20534 prep to,contributes
R13787 T20536 T20538 det the,activation
R13788 T20537 T20538 amod delayed,activation
R13789 T20538 T20535 pobj activation,to
R13790 T20539 T20538 prep of,activation
R13791 T20540 T20539 pobj Akt,of
R13792 T20541 T20529 punct .,create
R13793 T20542 T20543 nsubj It,is
R13794 T20543 T20543 ROOT is,is
R13795 T20544 T20543 advmod also,is
R13796 T20545 T20543 acomp important,is
R13797 T20546 T20547 aux to,note
R13798 T20547 T20543 xcomp note,is
R13799 T20548 T20550 mark that,observed
R13800 T20549 T20550 nsubj we,observed
R13801 T20550 T20547 ccomp observed,note
R13802 T20551 T20553 det an,increase
R13803 T20552 T20553 amod overall,increase
R13804 T20553 T20550 dobj increase,observed
R13805 T20554 T20553 prep in,increase
R13806 T20555 T20557 det the,level
R13807 T20556 T20557 compound protein,level
R13808 T20557 T20554 pobj level,in
R13809 T20558 T20557 prep of,level
R13810 T20559 T20558 pobj c-Jun,of
R13811 T20560 T20553 prep after,increase
R13812 T20561 T20560 pobj treatment,after
R13813 T20562 T20561 prep of,treatment
R13814 T20563 T20564 nummod L929,cells
R13815 T20564 T20562 pobj cells,of
R13816 T20565 T20553 prep with,increase
R13817 T20566 T20565 pobj zVAD.fmk,with
R13818 T20567 T20566 cc or,zVAD.fmk
R13819 T20568 T20566 conj TNFα,zVAD.fmk
R13820 T20569 T20566 punct ",",zVAD.fmk
R13821 T20570 T20571 nsubj which,was
R13822 T20571 T20553 relcl was,increase
R13823 T20572 T20573 det both,Akt
R13824 T20573 T20571 attr Akt,was
R13825 T20574 T20573 cc and,Akt
R13826 T20575 T20573 conj mTOR-dependent,Akt
R13827 T20576 T20578 punct (,6E
R13828 T20577 T20578 compound Fig.,6E
R13829 T20578 T20573 conj 6E,Akt
R13830 T20579 T20578 punct ",",6E
R13831 T20580 T20578 appos F,6E
R13832 T20581 T20578 punct ),6E
R13833 T20582 T20543 punct .,is
R13834 T20583 T20585 det These,data
R13835 T20584 T20585 amod new,data
R13836 T20585 T20586 nsubj data,led
R13837 T20586 T20586 ROOT led,led
R13838 T20587 T20586 dobj us,led
R13839 T20588 T20586 prep to,led
R13840 T20589 T20594 det an,conclusion
R13841 T20590 T20594 amod unexpected,conclusion
R13842 T20591 T20590 punct ",",unexpected
R13843 T20592 T20590 cc but,unexpected
R13844 T20593 T20590 conj important,unexpected
R13845 T20594 T20588 pobj conclusion,to
R13846 T20595 T20597 mark that,is
R13847 T20596 T20597 nsubj c-Jun,is
R13848 T20597 T20594 acl is,conclusion
R13849 T20598 T20597 acomp critical,is
R13850 T20599 T20598 prep for,critical
R13851 T20600 T20599 pobj necroptosis,for
R13852 T20601 T20586 punct ",",led
R13853 T20602 T20606 mark while,serve
R13854 T20603 T20604 compound JNK,activity
R13855 T20604 T20606 nsubj activity,serve
R13856 T20605 T20606 aux may,serve
R13857 T20606 T20586 advcl serve,led
R13858 T20607 T20606 prep as,serve
R13859 T20608 T20610 det a,marker
R13860 T20609 T20610 amod useful,marker
R13861 T20610 T20607 pobj marker,as
R13862 T20611 T20610 prep of,marker
R13863 T20612 T20613 compound pathway,activation
R13864 T20613 T20611 pobj activation,of
R13865 T20614 T20586 punct ",",led
R13866 T20615 T20586 cc but,led
R13867 T20616 T20617 aux may,be
R13868 T20617 T20586 conj be,led
R13869 T20618 T20619 advmod either,redundant
R13870 T20619 T20617 acomp redundant,be
R13871 T20620 T20622 punct (,phosphorylation
R13872 T20621 T20622 compound e.g.,phosphorylation
R13873 T20622 T20632 nsubj phosphorylation,occur
R13874 T20623 T20622 prep of,phosphorylation
R13875 T20624 T20623 pobj c-Jun,of
R13876 T20625 T20622 prep on,phosphorylation
R13877 T20626 T20627 det a,site
R13878 T20627 T20625 pobj site,on
R13879 T20628 T20627 amod other,site
R13880 T20629 T20632 mark than,occur
R13881 T20630 T20632 nsubj Ser63,occur
R13882 T20631 T20632 aux may,occur
R13883 T20632 T20617 advcl occur,be
R13884 T20633 T20632 dobj [,occur
R13885 T20634 T20635 nummod 44,]
R13886 T20635 T20633 nmod ],[
R13887 T20636 T20633 punct ),[
R13888 T20637 T20633 cc or,[
R13889 T20638 T20633 conj dispensable,[
R13890 T20639 T20638 advmod functionally,dispensable
R13891 T20640 T20586 punct .,led
R13892 T20641 T20645 prep In,need
R13893 T20642 T20641 pobj addition,In
R13894 T20643 T20645 punct ",",need
R13895 T20644 T20645 nsubj researchers,need
R13896 T20645 T20645 ROOT need,need
R13897 T20646 T20647 aux to,use
R13898 T20647 T20645 xcomp use,need
R13899 T20648 T20647 dobj caution,use
R13900 T20649 T20650 advmod when,using
R13901 T20650 T20647 advcl using,use
R13902 T20651 T20652 advmod SP600125,due
R13903 T20652 T20650 dobj due,using
R13904 T20653 T20652 pcomp to,due
R13905 T20654 T20656 amod potantial,effects
R13906 T20655 T20656 amod off-target,effects
R13907 T20656 T20653 pobj effects,to
R13908 T20657 T20645 punct .,need
R22340 T32460 T32468 nsubj Model,signaling
R22341 T32461 T32460 prep of,Model
R22342 T32462 T32461 pobj RIP1,of
R22343 T32463 T32462 punct ",",RIP1
R22344 T32464 T32462 conj Akt,RIP1
R22345 T32465 T32464 cc and,Akt
R22346 T32466 T32464 conj JNK,Akt
R22347 T32467 T32468 amod dependent,signaling
R22348 T32468 T32468 ROOT signaling,signaling
R22349 T32469 T32468 prep in,signaling
R22350 T32470 T32472 amod necroptotic,cells
R22351 T32471 T32472 compound L929,cells
R22352 T32472 T32469 pobj cells,in
R22353 T32473 T32468 punct .,signaling
R22354 T32474 T32475 compound Akt,phosphorylation
R22355 T32475 T32480 nsubj phosphorylation,requires
R22356 T32476 T32475 prep at,phosphorylation
R22357 T32477 T32476 pobj Thr308,at
R22358 T32478 T32480 prep during,requires
R22359 T32479 T32478 pobj necroptosis,during
R22360 T32480 T32480 ROOT requires,requires
R22361 T32481 T32480 dobj inputs,requires
R22362 T32482 T32481 prep from,inputs
R22363 T32483 T32485 det both,factors
R22364 T32484 T32485 compound growth,factors
R22365 T32485 T32482 pobj factors,from
R22366 T32486 T32485 cc and,factors
R22367 T32487 T32488 nummod RIP1,kinase
R22368 T32488 T32485 conj kinase,factors
R22369 T32489 T32480 punct .,requires
R22370 T32490 T32496 nsubj Downstream,leads
R22371 T32491 T32490 prep from,Downstream
R22372 T32492 T32491 pobj Akt,from
R22373 T32493 T32490 punct ",",Downstream
R22374 T32494 T32495 compound JNK,activation
R22375 T32495 T32496 nsubj activation,leads
R22376 T32496 T32496 ROOT leads,leads
R22377 T32497 T32498 aux to,TNFα
R22378 T32498 T32496 xcomp TNFα,leads
R22379 T32499 T32498 dobj synthesis,TNFα
R22380 T32500 T32496 punct .,leads
R22381 T32501 T32507 nsubj Activation,leads
R22382 T32502 T32501 prep of,Activation
R22383 T32503 T32502 pobj Akt,of
R22384 T32504 T32507 prep during,leads
R22385 T32505 T32504 pobj necroptosis,during
R22386 T32506 T32507 advmod also,leads
R22387 T32507 T32507 ROOT leads,leads
R22388 T32508 T32509 det the,phosphorylation
R22389 T32509 T32507 dobj phosphorylation,leads
R22390 T32510 T32509 prep of,phosphorylation
R22391 T32511 T32514 amod several,substrates
R22392 T32512 T32514 amod known,substrates
R22393 T32513 T32514 compound Akt,substrates
R22394 T32514 T32510 pobj substrates,of
R22395 T32515 T32514 punct ",",substrates
R22396 T32516 T32517 amod such,as
R22397 T32517 T32509 prep as,phosphorylation
R22398 T32518 T32517 pobj mTOR,as
R22399 T32519 T32518 punct ",",mTOR
R22400 T32520 T32521 nsubj which,contribute
R22401 T32521 T32509 relcl contribute,phosphorylation
R22402 T32522 T32521 prep to,contribute
R22403 T32523 T32524 det the,execution
R22404 T32524 T32522 pobj execution,to
R22405 T32525 T32524 prep of,execution
R22406 T32526 T32527 amod necroptotic,death
R22407 T32527 T32525 pobj death,of
R22408 T32528 T32524 prep in,execution
R22409 T32529 T32530 nummod L929,cells
R22410 T32530 T32528 pobj cells,in
R22411 T32531 T32507 punct .,leads

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T19655 4392-4407 Phosphorylation denotes phosphorylation
T19654 4411-4416 Protein denotes c-Jun
T19653 4293-4296 Protein denotes JNK
T19652 4252-4257 Protein denotes c-Jun
T19651 4039-4047 Positive_regulation denotes increase
T19650 4039-4047 Positive_regulation denotes increase
T19649 4154-4158 Protein denotes mTOR
T19648 4146-4149 Protein denotes Akt
T19647 4125-4129 Protein denotes TNFα
T19646 4113-4121 Protein denotes zVAD.fmk
T19645 4072-4077 Protein denotes c-Jun
T19644 3963-3973 Positive_regulation denotes activation
T19643 3884-3893 Positive_regulation denotes dependent
T19642 3872-3882 Gene_expression denotes production
T19641 3977-3980 Protein denotes Akt
T19640 3897-3902 Protein denotes c-Jun
T19639 3857-3871 Protein denotes autocrine TNFα
T19638 3603-3607 Regulation denotes role
T19637 3732-3741 Negative_regulation denotes knockdown
T19636 3652-3661 Gene_expression denotes synthesis
T19635 3720-3731 Protein denotes c-Jun siRNA
T19634 3637-3651 Protein denotes autocrine TNFα
T19633 3612-3617 Protein denotes c-Jun
T19632 3356-3365 Negative_regulation denotes reduction
T19631 3374-3384 Gene_expression denotes production
T19630 3544-3547 Protein denotes JNK
T19629 3369-3373 Protein denotes TNFα
T19628 3236-3246 Negative_regulation denotes inhibiting
T19627 3251-3266 Phosphorylation denotes phosphorylation
T19626 3197-3212 Phosphorylation denotes phosphorylation
T19625 3155-3165 Negative_regulation denotes inhibition
T19624 3270-3275 Protein denotes c-Jun
T19623 3216-3219 Protein denotes Akt
T19622 3182-3186 Protein denotes JNK1
T19621 3049-3058 Negative_regulation denotes inhibitor
T19620 3124-3130 Protein denotes S10B–G
T19619 3119-3122 Protein denotes Fig
T19618 3113-3117 Protein denotes JNK2
T19617 3104-3108 Protein denotes JNK1
T19616 3060-3063 Protein denotes JNK
T19575 1576-1579 Protein denotes Akt
T19574 1547-1550 Protein denotes Akt
T19573 929-937 Positive_regulation denotes required
T19572 929-937 Positive_regulation denotes required
T19571 995-1005 Negative_regulation denotes inhibition
T19570 949-964 Phosphorylation denotes phosphorylation
T32449 1340-1344 Protein denotes TNFα
T32448 1316-1319 Protein denotes JNK
T32447 1311-1314 Protein denotes Akt
T32446 1237-1245 Positive_regulation denotes requires
T32445 1192-1207 Phosphorylation denotes phosphorylation
T32444 1282-1293 Protein denotes RIP1 kinase
T32443 1188-1191 Protein denotes Akt
T32442 1137-1140 Protein denotes JNK
T32441 1129-1132 Protein denotes Akt
T32440 1123-1127 Protein denotes RIP1
T32459 1398-1403 Positive_regulation denotes leads
T32458 1398-1403 Positive_regulation denotes leads
T32457 1408-1423 Phosphorylation denotes phosphorylation
T32456 1408-1423 Phosphorylation denotes phosphorylation
T32455 1356-1366 Positive_regulation denotes Activation
T32454 1465-1469 Protein denotes mTOR
T32453 1441-1444 Protein denotes Akt
T32452 1370-1373 Protein denotes Akt
T32451 1345-1354 Gene_expression denotes synthesis
T32450 1320-1330 Positive_regulation denotes activation
T19569 949-964 Phosphorylation denotes phosphorylation
T19568 987-994 Protein denotes caspase
T19567 968-971 Protein denotes Akt
T19566 942-948 Protein denotes Thr308
T19565 898-909 Protein denotes RIP1 kinase
T19564 843-853 Positive_regulation denotes sufficient
T19563 843-853 Positive_regulation denotes sufficient
T19562 808-818 Gene_expression denotes expression
T19561 808-818 Gene_expression denotes expression
T19560 826-829 Protein denotes Akt
T19559 822-825 Protein denotes Myr
T19558 671-681 Gene_expression denotes Expression
T19557 671-681 Gene_expression denotes Expression
T19556 735-742 Protein denotes Myr-Akt
T19555 720-723 Protein denotes Akt
T19554 650-662 Localization denotes localization
T19553 666-669 Protein denotes Akt
T19552 537-545 Positive_regulation denotes requires
T19551 514-529 Phosphorylation denotes phosphorylation
T19550 533-536 Protein denotes Akt
T19549 378-383 Binding denotes leads
T19548 322-329 Binding denotes engaged
T19547 359-370 Protein denotes RIP1 kinase
T19546 295-305 Protein denotes Akt kinase
T19545 230-237 Protein denotes caspase
T19544 103-114 Protein denotes RIP1 kinase
T19543 0-5 Gene_expression denotes Model
T19542 0-5 Gene_expression denotes Model
T19541 0-5 Gene_expression denotes Model
T19540 23-26 Protein denotes JNK
T19539 15-18 Protein denotes Akt
T19538 9-13 Protein denotes RIP1
T19612 2904-2919 Phosphorylation denotes phosphorylation
T19611 2886-2893 Negative_regulation denotes inhibit
T19610 2900-2903 Protein denotes Akt
T19609 2822-2840 Protein denotes PI3K [41] and PDK1
T19608 2805-2810 Protein denotes p110δ
T19607 2602-2611 Negative_regulation denotes inhibited
T19606 2642-2657 Phosphorylation denotes phosphorylation
T19605 2668-2671 Protein denotes Akt
T19604 2389-2397 Positive_regulation denotes examined
T19603 2424-2434 Negative_regulation denotes inhibition
T19602 2402-2417 Phosphorylation denotes phosphorylation
T19601 2474-2477 Protein denotes JNK
T19600 2398-2401 Protein denotes Akt
T19599 2257-2267 Positive_regulation denotes activation
T19598 2144-2154 Positive_regulation denotes connecting
T19597 2287-2296 Gene_expression denotes synthesis
T19596 2257-2267 Positive_regulation denotes activation
T19595 2109-2119 Positive_regulation denotes activation
T19594 2272-2286 Protein denotes autocrine TNFα
T19593 2253-2256 Protein denotes JNK
T19592 2155-2166 Protein denotes RIP1 kinase
T19591 2105-2108 Protein denotes Akt
T19590 1867-1882 Phosphorylation denotes phosphorylation
T19589 1867-1882 Phosphorylation denotes phosphorylation
T19588 2014-2020 Protein denotes mTORC1
T19587 1896-1899 Protein denotes Akt
T19586 1886-1892 Protein denotes Thr308
T19585 1551-1561 Negative_regulation denotes inhibitors
T19584 1541-1546 Negative_regulation denotes Using
T19583 1541-1546 Negative_regulation denotes Using
T19582 1541-1546 Negative_regulation denotes Using
T19581 1652-1662 Positive_regulation denotes activation
T19580 1598-1608 Gene_expression denotes expression
T19579 1563-1572 Negative_regulation denotes knockdown
T19578 1551-1561 Negative_regulation denotes inhibitors
T19577 1666-1669 Protein denotes Akt
T19576 1612-1623 Protein denotes Akt mutants
T19615 3045-3048 Protein denotes JNK
T19614 3009-3012 Protein denotes JNK
T19613 2886-2893 Negative_regulation denotes inhibit
R13056 T19642 T19643 themeOf production,dependent
R13057 T19645 T19650 themeOf c-Jun,increase
R13058 T19645 T19651 themeOf c-Jun,increase
R13059 T19647 T19651 causeOf TNFα,increase
R13060 T19654 T19655 themeOf c-Jun,phosphorylation
R22329 T32443 T32445 themeOf Akt,phosphorylation
R22330 T32445 T32446 themeOf phosphorylation,requires
R22331 T32448 T32450 themeOf JNK,activation
R22332 T32449 T32451 themeOf TNFα,synthesis
R22333 T32452 T32455 themeOf Akt,Activation
R22334 T32453 T32456 themeOf Akt,phosphorylation
R22335 T32454 T32457 themeOf mTOR,phosphorylation
R22336 T32455 T32458 causeOf Activation,leads
R22337 T32455 T32459 causeOf Activation,leads
R22338 T32456 T32458 themeOf phosphorylation,leads
R22339 T32457 T32459 themeOf phosphorylation,leads
R13000 T19538 T19541 themeOf RIP1,Model
R13001 T19539 T19542 themeOf Akt,Model
R13002 T19540 T19543 themeOf JNK,Model
R13003 T19546 T19548 themeOf Akt kinase,engaged
R13004 T19547 T19549 themeOf RIP1 kinase,leads
R13005 T19550 T19551 themeOf Akt,phosphorylation
R13006 T19551 T19552 themeOf phosphorylation,requires
R13007 T19553 T19554 themeOf Akt,localization
R13008 T19555 T19557 themeOf Akt,Expression
R13009 T19556 T19558 themeOf Myr-Akt,Expression
R13010 T19559 T19561 themeOf Myr,expression
R13011 T19560 T19562 themeOf Akt,expression
R13012 T19561 T19563 themeOf expression,sufficient
R13013 T19562 T19564 themeOf expression,sufficient
R13014 T19566 T19569 themeOf Thr308,phosphorylation
R13015 T19567 T19570 themeOf Akt,phosphorylation
R13016 T19568 T19571 themeOf caspase,inhibition
R13017 T19569 T19572 themeOf phosphorylation,required
R13018 T19570 T19573 themeOf phosphorylation,required
R13019 T19574 T19578 themeOf Akt,inhibitors
R13020 T19575 T19579 themeOf Akt,knockdown
R13021 T19576 T19580 themeOf Akt mutants,expression
R13022 T19577 T19581 themeOf Akt,activation
R13023 T19578 T19582 themeOf inhibitors,Using
R13024 T19579 T19583 themeOf knockdown,Using
R13025 T19580 T19584 themeOf expression,Using
R13026 T19580 T19585 themeOf expression,inhibitors
R13027 T19586 T19589 themeOf Thr308,phosphorylation
R13028 T19587 T19590 themeOf Akt,phosphorylation
R13029 T19591 T19595 themeOf Akt,activation
R13030 T19593 T19596 themeOf JNK,activation
R13031 T19594 T19597 themeOf autocrine TNFα,synthesis
R13032 T19596 T19598 themeOf activation,connecting
R13033 T19597 T19599 themeOf synthesis,activation
R13034 T19600 T19602 themeOf Akt,phosphorylation
R13035 T19601 T19603 themeOf JNK,inhibition
R13036 T19602 T19604 themeOf phosphorylation,examined
R13037 T19605 T19606 themeOf Akt,phosphorylation
R13038 T19606 T19607 themeOf phosphorylation,inhibited
R13039 T19610 T19611 themeOf Akt,inhibit
R13040 T19610 T19612 themeOf Akt,phosphorylation
R13041 T19612 T19613 themeOf phosphorylation,inhibit
R13042 T19615 T19621 themeOf JNK,inhibitor
R13043 T19622 T19625 themeOf JNK1,inhibition
R13044 T19623 T19626 themeOf Akt,phosphorylation
R13045 T19624 T19627 themeOf c-Jun,phosphorylation
R13046 T19627 T19628 themeOf phosphorylation,inhibiting
R13047 T19629 T19631 themeOf TNFα,production
R13048 T19631 T19632 themeOf production,reduction
R13049 T19633 T19638 causeOf c-Jun,role
R13050 T19634 T19636 themeOf autocrine TNFα,synthesis
R13051 T19635 T19637 themeOf c-Jun siRNA,knockdown
R13052 T19636 T19638 themeOf synthesis,role
R13053 T19639 T19642 themeOf autocrine TNFα,production
R13054 T19640 T19643 causeOf c-Jun,dependent
R13055 T19641 T19644 themeOf Akt,activation

test3

Id Subject Object Predicate Lexical cue
T32300 1408-1423 Phosphorylation denotes phosphorylation
T32299 1398-1403 Positive_regulation denotes leads
T32298 1356-1366 Positive_regulation denotes Activation
T32297 1345-1354 Gene_expression denotes synthesis
T32296 1340-1344 Protein denotes TNFα
T32295 1282-1286 Protein denotes RIP1
T32294 1192-1207 Phosphorylation denotes phosphorylation
T32293 1123-1127 Protein denotes RIP1
T32292 1340-1344 Protein denotes TNFα
T32291 1282-1286 Protein denotes RIP1
T32290 1123-1127 Protein denotes RIP1
T18275 2805-2818 Protein denotes p110δ subunit
T18311 4411-4416 Protein denotes c-Jun
T18310 4392-4407 Phosphorylation denotes phosphorylation
T18309 4252-4257 Protein denotes c-Jun
T18308 4159-4168 Regulation denotes dependent
T18307 4125-4129 Protein denotes TNFα
T18306 4072-4077 Protein denotes c-Jun
T18305 4039-4047 Positive_regulation denotes increase
T18304 3963-3973 Positive_regulation denotes activation
T18303 3936-3947 Positive_regulation denotes contributes
T18302 3897-3902 Protein denotes c-Jun
T18301 3884-3893 Regulation denotes dependent
T18300 3872-3882 Gene_expression denotes production
T18299 3867-3871 Protein denotes TNFα
T18298 3857-3866 Regulation denotes autocrine
T18297 3807-3814 Negative_regulation denotes reduced
T18296 3787-3802 Phosphorylation denotes phosphorylation
T18295 3732-3741 Negative_regulation denotes knockdown
T18294 3720-3725 Protein denotes c-Jun
T18293 3652-3661 Gene_expression denotes synthesis
T18292 3647-3651 Protein denotes TNFα
T18291 3612-3617 Protein denotes c-Jun
T18290 3374-3384 Gene_expression denotes production
T18289 3369-3373 Protein denotes TNFα
T18288 3356-3365 Negative_regulation denotes reduction
T18287 3270-3275 Protein denotes c-Jun
T18286 3251-3266 Phosphorylation denotes phosphorylation
T18285 3236-3246 Negative_regulation denotes inhibiting
T18284 3197-3212 Phosphorylation denotes phosphorylation
T18283 3187-3188 Protein denotes 2
T18282 3182-3186 Protein denotes JNK1
T18281 3169-3178 Negative_regulation denotes knockdown
T18280 3113-3117 Protein denotes JNK2
T18279 3104-3108 Protein denotes JNK1
T18278 2904-2919 Phosphorylation denotes phosphorylation
T18277 2886-2893 Negative_regulation denotes inhibit
T18276 2836-2840 Protein denotes PDK1
T18274 2642-2657 Phosphorylation denotes phosphorylation
T18273 2602-2611 Negative_regulation denotes inhibited
T18272 2569-2579 Gene_expression denotes production
T18271 2564-2568 Protein denotes TNFα
T18270 2554-2563 Negative_regulation denotes inhibited
T18269 2402-2417 Phosphorylation denotes phosphorylation
T18268 2287-2296 Gene_expression denotes synthesis
T18267 2282-2286 Protein denotes TNFα
T18266 2272-2281 Regulation denotes autocrine
T18265 2155-2159 Protein denotes RIP1
T18264 1867-1882 Phosphorylation denotes phosphorylation
T18263 1652-1662 Positive_regulation denotes activation
T18262 1598-1608 Gene_expression denotes expression
T18261 1563-1572 Negative_regulation denotes knockdown
T18260 1551-1561 Negative_regulation denotes inhibitors
T18259 949-964 Phosphorylation denotes phosphorylation
T18258 929-937 Positive_regulation denotes required
T18257 898-902 Protein denotes RIP1
T18256 822-829 Protein denotes Myr-Akt
T18255 808-818 Gene_expression denotes expression
T18254 735-742 Protein denotes Myr-Akt
T18253 671-681 Gene_expression denotes Expression
T18252 650-662 Localization denotes localization
T18251 514-529 Phosphorylation denotes phosphorylation
T18250 415-430 Phosphorylation denotes phosphorylation
T18249 399-407 Positive_regulation denotes increase
T18248 359-363 Protein denotes RIP1
T18247 103-107 Protein denotes RIP1
T18246 9-13 Protein denotes RIP1
T18245 4411-4416 Protein denotes c-Jun
T18244 4252-4257 Protein denotes c-Jun
T18243 4125-4129 Protein denotes TNFα
T18242 4072-4077 Protein denotes c-Jun
T18241 3897-3902 Protein denotes c-Jun
T18240 3867-3871 Protein denotes TNFα
T18239 3720-3725 Protein denotes c-Jun
T18238 3647-3651 Protein denotes TNFα
T18237 3612-3617 Protein denotes c-Jun
T18236 3369-3373 Protein denotes TNFα
T18235 3270-3275 Protein denotes c-Jun
T18234 3187-3188 Protein denotes 2
T18233 3182-3186 Protein denotes JNK1
T18232 3113-3117 Protein denotes JNK2
T18231 3104-3108 Protein denotes JNK1
T18230 2836-2840 Protein denotes PDK1
T18229 2805-2818 Protein denotes p110δ subunit
T18228 2564-2568 Protein denotes TNFα
T18227 2282-2286 Protein denotes TNFα
T18226 2155-2159 Protein denotes RIP1
T18225 898-902 Protein denotes RIP1
T18224 822-829 Protein denotes Myr-Akt
T18223 735-742 Protein denotes Myr-Akt
T18222 359-363 Protein denotes RIP1
T18221 103-107 Protein denotes RIP1
T18220 9-13 Protein denotes RIP1
R12106 T18250 T18249 themeOf phosphorylation,increase
R12107 T18254 T18253 themeOf Myr-Akt,Expression
R12108 T18256 T18255 themeOf Myr-Akt,expression
R12109 T18259 T18258 themeOf phosphorylation,required
R12110 T18267 T18268 themeOf TNFα,synthesis
R12111 T18268 T18266 themeOf synthesis,autocrine
R12112 T18271 T18272 themeOf TNFα,production
R12113 T18272 T18270 themeOf production,inhibited
R12114 T18274 T18273 themeOf phosphorylation,inhibited
R12115 T18278 T18277 themeOf phosphorylation,inhibit
R12116 T18282 T18281 themeOf JNK1,knockdown
R12117 T18283 T18281 themeOf 2,knockdown
R12118 T18286 T18285 themeOf phosphorylation,inhibiting
R12119 T18287 T18286 themeOf c-Jun,phosphorylation
R12120 T18289 T18290 themeOf TNFα,production
R12121 T18290 T18288 themeOf production,reduction
R12122 T18292 T18293 themeOf TNFα,synthesis
R12123 T18294 T18295 themeOf c-Jun,knockdown
R12124 T18296 T18297 themeOf phosphorylation,reduced
R12125 T18298 T18301 themeOf autocrine,dependent
R12126 T18299 T18300 themeOf TNFα,production
R12127 T18300 T18298 themeOf production,autocrine
R12128 T18300 T18301 themeOf production,dependent
R12129 T18302 T18301 causeOf c-Jun,dependent
R12130 T18306 T18305 themeOf c-Jun,increase
R12131 T18307 T18305 themeOf TNFα,increase
R12132 T18311 T18310 themeOf c-Jun,phosphorylation
R22254 T32296 T32297 themeOf TNFα,synthesis
R22255 T32298 T32299 causeOf Activation,leads
R22256 T32300 T32299 themeOf phosphorylation,leads