PMC:3585731 / 33785-34067
Annnotations
testone
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T13496 | 227-231 | Protein | denotes | TNFα |
T13551 | 219-226 | Positive_regulation | denotes | promote |
T13550 | 158-166 | Positive_regulation | denotes | allowing |
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T14913 | 276-281 | NN | denotes | death |
T14912 | 271-275 | NN | denotes | cell |
T14911 | 262-270 | JJ | denotes | eventual |
T14910 | 258-261 | CC | denotes | and |
T14909 | 247-257 | NN | denotes | activation |
T14908 | 243-246 | NN | denotes | JNK |
T14907 | 241-242 | -COMMA- | denotes | , |
T14906 | 232-241 | NN | denotes | synthesis |
T14905 | 227-231 | NN | denotes | TNFα |
T14904 | 219-226 | VB | denotes | promote |
T14903 | 217-218 | -COMMA- | denotes | , |
T14902 | 206-217 | NN | denotes | necroptosis |
T14901 | 199-205 | IN | denotes | during |
T14900 | 188-198 | NN | denotes | substrates |
T14899 | 174-187 | VB | denotes | phosphorylate |
T14898 | 171-173 | TO | denotes | to |
T14897 | 167-170 | NN | denotes | Akt |
T14896 | 158-166 | VB | denotes | allowing |
T14895 | 156-157 | -COMMA- | denotes | , |
T14894 | 150-156 | NN | denotes | kinase |
T14893 | 146-149 | NN | denotes | Akt |
T14892 | 142-145 | CC | denotes | and |
T14891 | 132-141 | NN | denotes | machinery |
T14890 | 120-131 | JJ | denotes | necroptotic |
T14889 | 112-119 | IN | denotes | between |
T14888 | 107-111 | NN | denotes | link |
T14887 | 98-106 | JJ | denotes | critical |
T14886 | 96-97 | DT | denotes | a |
T14885 | 87-95 | VB | denotes | provides |
T14884 | 71-86 | NN | denotes | phosphorylation |
T14883 | 64-70 | NN | denotes | Thr308 |
T14882 | 43-63 | JJ | denotes | necroptosis-specific |
T14881 | 38-42 | IN | denotes | that |
T14880 | 35-37 | VB | denotes | is |
T14879 | 33-34 | -COMMA- | denotes | , |
T14878 | 26-33 | NN | denotes | results |
T14877 | 20-25 | DT | denotes | these |
T14876 | 17-19 | IN | denotes | on |
T14875 | 11-16 | VB | denotes | based |
T14874 | 9-10 | -COMMA- | denotes | , |
T14872 | 0-3 | PRP-DOLLAR- | denotes | Our |
T14873 | 4-9 | NN | denotes | model |
R9868 | T14873 | T14872 | arg1Of | model,Our |
R9869 | T14873 | T14874 | arg1Of | model,"," |
R9870 | T14873 | T14875 | arg1Of | model,based |
R9871 | T14873 | T14880 | arg1Of | model,is |
R9872 | T14876 | T14875 | arg2Of | on,based |
R9873 | T14878 | T14876 | arg2Of | results,on |
R9874 | T14878 | T14877 | arg1Of | results,these |
R9875 | T14880 | T14879 | arg1Of | is,"," |
R9876 | T14884 | T14882 | arg1Of | phosphorylation,necroptosis-specific |
R9877 | T14884 | T14883 | arg1Of | phosphorylation,Thr308 |
R9878 | T14884 | T14885 | arg1Of | phosphorylation,provides |
R9879 | T14884 | T14904 | arg1Of | phosphorylation,promote |
R9880 | T14885 | T14895 | arg1Of | provides,"," |
R9881 | T14885 | T14896 | modOf | provides,allowing |
R9882 | T14885 | T14903 | arg1Of | provides,"," |
R9883 | T14888 | T14885 | arg2Of | link,provides |
R9884 | T14888 | T14886 | arg1Of | link,a |
R9885 | T14888 | T14887 | arg1Of | link,critical |
R9886 | T14888 | T14889 | arg1Of | link,between |
R9887 | T14891 | T14890 | arg1Of | machinery,necroptotic |
R9888 | T14891 | T14892 | arg1Of | machinery,and |
R9889 | T14892 | T14889 | arg2Of | and,between |
R9890 | T14894 | T14892 | arg2Of | kinase,and |
R9891 | T14894 | T14893 | arg1Of | kinase,Akt |
R9892 | T14897 | T14896 | arg2Of | Akt,allowing |
R9893 | T14897 | T14899 | arg1Of | Akt,phosphorylate |
R9894 | T14899 | T14896 | arg3Of | phosphorylate,allowing |
R9895 | T14899 | T14898 | arg1Of | phosphorylate,to |
R9896 | T14899 | T14901 | arg1Of | phosphorylate,during |
R9897 | T14900 | T14899 | arg2Of | substrates,phosphorylate |
R9898 | T14902 | T14901 | arg2Of | necroptosis,during |
R9899 | T14903 | T14880 | arg2Of | ",",is |
R9900 | T14903 | T14881 | arg1Of | ",",that |
R9901 | T14904 | T14903 | arg2Of | promote,"," |
R9902 | T14906 | T14905 | arg1Of | synthesis,TNFα |
R9903 | T14906 | T14907 | arg1Of | synthesis,"," |
R9904 | T14907 | T14910 | arg1Of | ",",and |
R9905 | T14909 | T14907 | arg2Of | activation,"," |
R9906 | T14909 | T14908 | arg1Of | activation,JNK |
R9907 | T14910 | T14904 | arg2Of | and,promote |
R9908 | T14913 | T14910 | arg2Of | death,and |
R9909 | T14913 | T14911 | arg1Of | death,eventual |
R9910 | T14913 | T14912 | arg1Of | death,cell |
bionlp-st-ge-2016-test-proteins
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T13877 | 227-231 | Protein | denotes | TNFα |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T15053 | 167-170 | http://www.uniprot.org/uniprot/P31751 | denotes | Akt |
T15052 | 146-149 | http://www.uniprot.org/uniprot/P31751 | denotes | Akt |
T15018 | 167-170 | http://www.uniprot.org/uniprot/P31749 | denotes | Akt |
T15017 | 146-149 | http://www.uniprot.org/uniprot/P31749 | denotes | Akt |
T15098 | 227-231 | http://www.uniprot.org/uniprot/P01375 | denotes | TNFα |
T15088 | 167-170 | http://www.uniprot.org/uniprot/Q9Y243 | denotes | Akt |
T15087 | 146-149 | http://www.uniprot.org/uniprot/Q9Y243 | denotes | Akt |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T13955 | 232-241 | http://purl.obolibrary.org/obo/GO_0009058 | denotes | synthesis |
T13941 | 243-246 | http://purl.obolibrary.org/obo/GO_0004705 | denotes | JNK |
T13937 | 71-86 | http://purl.obolibrary.org/obo/GO_0016310 | denotes | phosphorylation |
T13925 | 276-281 | http://purl.obolibrary.org/obo/GO_0016265 | denotes | death |
T13919 | 271-281 | http://purl.obolibrary.org/obo/GO_0008219 | denotes | cell death |
T13905 | 206-217 | http://purl.obolibrary.org/obo/GO_0097528 | denotes | necroptosis |
T13904 | 43-54 | http://purl.obolibrary.org/obo/GO_0097528 | denotes | necroptosis |
T13891 | 206-217 | http://purl.obolibrary.org/obo/GO_0070266 | denotes | necroptosis |
T13890 | 43-54 | http://purl.obolibrary.org/obo/GO_0070266 | denotes | necroptosis |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T13959 | 243-246 | http://purl.obolibrary.org/obo/GO_0004705 | denotes | JNK |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T13969 | 271-275 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T13722 | 0-282 | Sentence | denotes | Our model, based on these results, is that necroptosis-specific Thr308 phosphorylation provides a critical link between necroptotic machinery and Akt kinase, allowing Akt to phosphorylate substrates during necroptosis, promote TNFα synthesis, JNK activation and eventual cell death. |
T212 | 0-282 | Sentence | denotes | Our model, based on these results, is that necroptosis-specific Thr308 phosphorylation provides a critical link between necroptotic machinery and Akt kinase, allowing Akt to phosphorylate substrates during necroptosis, promote TNFα synthesis, JNK activation and eventual cell death. |
simple1
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T14060 | 227-231 | Protein | denotes | TNFα |
BioNLP16_DUT
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T14983 | 232-241 | Gene_expression | denotes | synthesis |
T14982 | 219-226 | Positive_regulation | denotes | promote |
T14956 | 227-231 | Protein | denotes | TNFα |
R9940 | T14956 | T14983 | themeOf | TNFα,synthesis |
R9948 | T14983 | T14982 | themeOf | synthesis,promote |
BioNLP16_Messiy
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T15293 | 232-241 | Gene_expression | denotes | synthesis |
T15292 | 219-226 | Positive_regulation | denotes | promote |
T15270 | 227-231 | Protein | denotes | TNFα |
R10032 | T15270 | T15293 | themeOf | TNFα,synthesis |
R10041 | T15293 | T15292 | themeOf | synthesis,promote |
DLUT931
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T15143 | 227-231 | Protein | denotes | TNFα |
bionlp-st-ge-2016-test-ihmc
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T15770 | 243-257 | Positive_regulation | denotes | JNK activation |
T15732 | 167-170 | Protein | denotes | Akt |
T15661 | 243-246 | Protein | denotes | JNK |
T15650 | 146-156 | Protein | denotes | Akt kinase |
T15635 | 64-70 | Entity | denotes | Thr308 |
T15615 | 188-198 | Entity | denotes | substrates |
T15731 | 146-149 | Protein | denotes | Akt |
T15726 | 227-241 | Protein | denotes | TNFα synthesis |
R10225 | T15661 | T15770 | themeOf | JNK,JNK activation |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T16656 | 281-282 | . | denotes | . |
T16655 | 276-281 | NN | denotes | death |
T16654 | 271-275 | NN | denotes | cell |
T16653 | 262-270 | JJ | denotes | eventual |
T16652 | 258-261 | CC | denotes | and |
T16651 | 247-257 | NN | denotes | activation |
T16650 | 243-246 | NNP | denotes | JNK |
T16649 | 241-242 | , | denotes | , |
T16648 | 232-241 | NN | denotes | synthesis |
T16647 | 227-231 | NNP | denotes | TNFα |
T16646 | 219-226 | VB | denotes | promote |
T16645 | 217-218 | , | denotes | , |
T16644 | 206-217 | NN | denotes | necroptosis |
T16643 | 199-205 | IN | denotes | during |
T16642 | 188-198 | NNS | denotes | substrates |
T16641 | 174-187 | VB | denotes | phosphorylate |
T16640 | 171-173 | TO | denotes | to |
T16639 | 167-170 | NNP | denotes | Akt |
T16638 | 158-166 | VBG | denotes | allowing |
T16637 | 156-157 | , | denotes | , |
T16636 | 150-156 | NN | denotes | kinase |
T16635 | 146-149 | NNP | denotes | Akt |
T16634 | 142-145 | CC | denotes | and |
T16633 | 132-141 | NN | denotes | machinery |
T16632 | 120-131 | JJ | denotes | necroptotic |
T16631 | 112-119 | IN | denotes | between |
T16630 | 107-111 | NN | denotes | link |
T16629 | 98-106 | JJ | denotes | critical |
T16628 | 96-97 | DT | denotes | a |
T16627 | 87-95 | VBZ | denotes | provides |
T16626 | 71-86 | NN | denotes | phosphorylation |
T16625 | 64-70 | NNP | denotes | Thr308 |
T16624 | 43-63 | JJ | denotes | necroptosis-specific |
T16623 | 38-42 | IN | denotes | that |
T16622 | 35-37 | VBZ | denotes | is |
T16621 | 33-34 | , | denotes | , |
T16620 | 26-33 | NNS | denotes | results |
T16619 | 20-25 | DT | denotes | these |
T16618 | 17-19 | IN | denotes | on |
T16617 | 11-16 | VBN | denotes | based |
T16616 | 9-10 | , | denotes | , |
T16615 | 4-9 | NN | denotes | model |
T16614 | 0-3 | PRP$ | denotes | Our |
R11023 | T16641 | T16638 | ccomp | phosphorylate,allowing |
R11025 | T16642 | T16641 | dobj | substrates,phosphorylate |
R11026 | T16643 | T16641 | prep | during,phosphorylate |
R11027 | T16644 | T16643 | pobj | necroptosis,during |
R11029 | T16645 | T16641 | punct | ",",phosphorylate |
R11030 | T16646 | T16641 | dep | promote,phosphorylate |
R11032 | T16647 | T16648 | compound | TNFα,synthesis |
R11033 | T16648 | T16646 | dobj | synthesis,promote |
R11034 | T16649 | T16641 | punct | ",",phosphorylate |
R11036 | T16650 | T16651 | compound | JNK,activation |
R11037 | T16651 | T16641 | conj | activation,phosphorylate |
R11039 | T16652 | T16651 | cc | and,activation |
R11040 | T16653 | T16655 | amod | eventual,death |
R11041 | T16654 | T16655 | compound | cell,death |
R11043 | T16655 | T16651 | conj | death,activation |
R11044 | T16656 | T16622 | punct | .,is |
R11102 | T16614 | T16615 | poss | Our,model |
R11103 | T16615 | T16622 | nsubj | model,is |
R11104 | T16616 | T16615 | punct | ",",model |
R11105 | T16617 | T16615 | prep | based,model |
R11106 | T16618 | T16617 | prep | on,based |
R11107 | T16619 | T16620 | det | these,results |
R11108 | T16620 | T16618 | pobj | results,on |
R11109 | T16621 | T16615 | punct | ",",model |
R11110 | T16622 | T16622 | ROOT | is,is |
R11111 | T16623 | T16627 | mark | that,provides |
R11112 | T16624 | T16626 | amod | necroptosis-specific,phosphorylation |
R11113 | T16625 | T16626 | compound | Thr308,phosphorylation |
R11114 | T16626 | T16627 | nsubj | phosphorylation,provides |
R11115 | T16627 | T16622 | ccomp | provides,is |
R11116 | T16628 | T16630 | det | a,link |
R11117 | T16629 | T16630 | amod | critical,link |
R11118 | T16630 | T16627 | dobj | link,provides |
R11119 | T16631 | T16630 | prep | between,link |
R11120 | T16632 | T16633 | amod | necroptotic,machinery |
R11121 | T16633 | T16631 | pobj | machinery,between |
R11122 | T16634 | T16633 | cc | and,machinery |
R11123 | T16635 | T16636 | compound | Akt,kinase |
R11124 | T16636 | T16633 | conj | kinase,machinery |
R11125 | T16637 | T16627 | punct | ",",provides |
R11126 | T16638 | T16627 | advcl | allowing,provides |
R11127 | T16639 | T16641 | nsubj | Akt,phosphorylate |
R11128 | T16640 | T16641 | aux | to,phosphorylate |
bionlp-st-ge-2016-test-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T15449 | 247-257 | Positive_regulation | denotes | activation |
T15448 | 247-257 | Positive_regulation | denotes | activation |
T15447 | 232-241 | Gene_expression | denotes | synthesis |
T15446 | 243-246 | Protein | denotes | JNK |
T15445 | 227-231 | Protein | denotes | TNFα |
T15444 | 167-170 | Protein | denotes | Akt |
T15443 | 146-156 | Protein | denotes | Akt kinase |
R10123 | T15445 | T15447 | themeOf | TNFα,synthesis |
R10124 | T15446 | T15448 | themeOf | JNK,activation |
R10125 | T15447 | T15449 | themeOf | synthesis,activation |
test3
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T13688 | 232-241 | Gene_expression | denotes | synthesis |
T13687 | 227-231 | Protein | denotes | TNFα |
T13686 | 219-226 | Positive_regulation | denotes | promote |
T13685 | 174-187 | Phosphorylation | denotes | phosphorylate |
T13684 | 158-166 | Positive_regulation | denotes | allowing |
T13594 | 227-231 | Protein | denotes | TNFα |
R8962 | T13685 | T13684 | themeOf | phosphorylate,allowing |
R8963 | T13685 | T13686 | causeOf | phosphorylate,promote |
R8964 | T13687 | T13688 | themeOf | TNFα,synthesis |
R8965 | T13688 | T13686 | themeOf | synthesis,promote |