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PMC:3585731 / 31557-34067 JSONTXT

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testone

Id Subject Object Predicate Lexical cue
T13496 2455-2459 Protein denotes TNFα
T13495 2209-2215 Protein denotes p70S6K
T13494 2199-2203 Protein denotes MDM2
T13493 2192-2197 Protein denotes Foxo4
T13492 2185-2190 Protein denotes FoxO1
T13491 2133-2140 Protein denotes Myr-Akt
T13490 2026-2031 Protein denotes T308D
T13489 1782-1787 Protein denotes T308D
T13488 1752-1756 Protein denotes TNFα
T13487 1741-1746 Protein denotes c-Jun
T13486 1576-1580 Protein denotes PDK1
T13485 1406-1411 Protein denotes S473A
T13484 1339-1344 Protein denotes S473A
T13483 1214-1226 Protein denotes S473D mutant
T13482 758-761 Protein denotes Akt
T13481 150-157 Protein denotes Myr-Akt
T13480 96-100 Protein denotes TNFα
T13551 2447-2454 Positive_regulation denotes promote
T13550 2386-2394 Positive_regulation denotes allowing
T13549 2111-2125 Phosphorylation denotes phosphorylated
T13548 1714-1729 Phosphorylation denotes phosphorylation
T13547 1584-1597 Phosphorylation denotes phosphorylate
T13546 1530-1544 Phosphorylation denotes phosphorylated
T13545 1519-1523 Entity denotes site
T13544 1486-1495 Negative_regulation denotes inability
T13543 1441-1455 Phosphorylation denotes phosphorylated
T13542 1238-1252 Phosphorylation denotes phosphorylated
T13541 719-728 Negative_regulation denotes reduction
T13540 680-689 Negative_regulation denotes mutations
T13539 602-612 Regulation denotes regulation
T13538 579-594 Phosphorylation denotes phosphorylation
T13537 563-567 Regulation denotes role
T13536 452-461 Positive_regulation denotes following
T13535 436-451 Phosphorylation denotes phosphorylation
T13534 419-428 Positive_regulation denotes increased
T13533 345-354 Entity denotes PH domain
T13532 328-335 Negative_regulation denotes lacking
T13531 267-279 Localization denotes localization
T13530 190-197 Regulation denotes effects
T13529 140-149 Gene_expression denotes expressed
R8905 T13481 T13529 themeOf Myr-Akt,expressed
R8906 T13483 T13542 themeOf S473D mutant,phosphorylated
R8907 T13487 T13548 themeOf c-Jun,phosphorylation
R8908 T13488 T13548 themeOf TNFα,phosphorylation
R8909 T13490 T13549 themeOf T308D,phosphorylated
R8910 T13491 T13549 themeOf Myr-Akt,phosphorylated
R8911 T13494 T13549 themeOf MDM2,phosphorylated
R8912 T13495 T13549 causeOf p70S6K,phosphorylated
R8922 T13533 T13532 themeOf PH domain,lacking
R8923 T13535 T13534 themeOf phosphorylation,increased
R8924 T13535 T13536 themeOf phosphorylation,following
R8925 T13538 T13537 themeOf phosphorylation,role
R8926 T13540 T13541 causeOf mutations,reduction

2_test

Id Subject Object Predicate Lexical cue
23469174-8978681-90505450 800-802 8978681 denotes 38
23469174-23030823-90505451 1606-1608 23030823 denotes 39

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T14913 2504-2509 NN denotes death
T14912 2499-2503 NN denotes cell
T14911 2490-2498 JJ denotes eventual
T14910 2486-2489 CC denotes and
T14909 2475-2485 NN denotes activation
T14908 2471-2474 NN denotes JNK
T14907 2469-2470 -COMMA- denotes ,
T14906 2460-2469 NN denotes synthesis
T14905 2455-2459 NN denotes TNFα
T14904 2447-2454 VB denotes promote
T14903 2445-2446 -COMMA- denotes ,
T14902 2434-2445 NN denotes necroptosis
T14901 2427-2433 IN denotes during
T14900 2416-2426 NN denotes substrates
T14899 2402-2415 VB denotes phosphorylate
T14898 2399-2401 TO denotes to
T14897 2395-2398 NN denotes Akt
T14896 2386-2394 VB denotes allowing
T14895 2384-2385 -COMMA- denotes ,
T14894 2378-2384 NN denotes kinase
T14893 2374-2377 NN denotes Akt
T14892 2370-2373 CC denotes and
T14891 2360-2369 NN denotes machinery
T14890 2348-2359 JJ denotes necroptotic
T14889 2340-2347 IN denotes between
T14888 2335-2339 NN denotes link
T14887 2326-2334 JJ denotes critical
T14886 2324-2325 DT denotes a
T14885 2315-2323 VB denotes provides
T14884 2299-2314 NN denotes phosphorylation
T14883 2292-2298 NN denotes Thr308
T14882 2271-2291 JJ denotes necroptosis-specific
T14881 2266-2270 IN denotes that
T14880 2263-2265 VB denotes is
T14879 2261-2262 -COMMA- denotes ,
T14878 2254-2261 NN denotes results
T14877 2248-2253 DT denotes these
T14876 2245-2247 IN denotes on
T14875 2239-2244 VB denotes based
T14874 2237-2238 -COMMA- denotes ,
T14872 2228-2231 PRP-DOLLAR- denotes Our
T14871 2225-2226 -RRB- denotes )
T14870 2222-2225 NN denotes S8D
T14869 2217-2221 NN denotes Fig.
T14868 2216-2217 -LRB- denotes (
T14867 2209-2215 NN denotes p70S6K
T14866 2205-2208 CC denotes and
T14865 2203-2204 -COMMA- denotes ,
T14864 2199-2203 NN denotes MDM2
T14863 2197-2198 -COMMA- denotes ,
T14862 2192-2197 NN denotes Foxo4
T14861 2190-2191 -COMMA- denotes ,
T14860 2185-2190 NN denotes FoxO1
T14850 2126-2128 IN denotes by
T14849 2111-2125 VB denotes phosphorylated
T14848 2106-2110 VB denotes were
T14847 2101-2105 WDT denotes that
T14846 2090-2100 NN denotes substrates
T14845 2082-2089 JJ denotes several
T14844 2079-2081 IN denotes of
T14843 2063-2078 NN denotes phosphorylation
T14842 2052-2062 JJ denotes downstream
T14841 2048-2051 DT denotes the
T14840 2040-2047 VB denotes support
T14839 2036-2039 RB denotes not
T14838 2032-2035 VB denotes did
T14837 2026-2031 NN denotes T308D
T14836 2024-2025 -COMMA- denotes ,
T14835 2018-2024 VB denotes tested
T14834 2013-2017 WRB denotes When
T14833 2006-2011 NN denotes cells
T14832 2002-2005 DT denotes the
T14831 1999-2001 IN denotes in
T14830 1988-1998 NN denotes substrates
T14829 1985-1987 IN denotes of
T14828 1974-1984 NN denotes repertoire
T14827 1967-1973 JJ denotes entire
T14826 1963-1966 DT denotes the
T14825 1949-1962 VB denotes phosphorylate
T14824 1946-1948 TO denotes to
T14823 1937-1945 NN denotes activity
T14822 1926-1936 JJ denotes sufficient
T14821 1921-1925 VB denotes have
T14820 1917-1920 RB denotes not
T14819 1913-1916 MD denotes may
T14818 1906-1912 NN denotes kinase
T14817 1902-1905 DT denotes the
T14816 1899-1901 IN denotes of
T14815 1894-1898 NN denotes form
T14814 1887-1893 JJ denotes mutant
T14813 1882-1886 DT denotes this
T14812 1878-1881 CC denotes and
T14811 1862-1877 NN denotes phosphorylation
T14810 1859-1861 IN denotes of
T14809 1853-1858 NN denotes mimic
T14808 1845-1852 JJ denotes perfect
T14807 1843-1844 DT denotes a
T14806 1840-1842 VB denotes be
T14805 1836-1839 RB denotes not
T14804 1832-1835 MD denotes may
T14803 1830-1831 -COMMA- denotes ,
T14802 1821-1830 NN denotes construct
T14801 1817-1820 NN denotes Akt
T14800 1810-1816 JJ denotes active
T14799 1807-1809 DT denotes an
T14798 1801-1806 VB denotes being
T14797 1798-1800 IN denotes of
T14796 1792-1797 NN denotes spite
T14795 1789-1791 IN denotes in
T14794 1787-1788 -COMMA- denotes ,
T14793 1782-1787 NN denotes T308D
T14792 1777-1781 IN denotes that
T14791 1768-1776 VB denotes suggests
T14790 1763-1767 DT denotes This
T14789 1757-1761 NN denotes mRNA
T14788 1752-1756 NN denotes TNFα
T14787 1748-1751 CC denotes and
T14786 1746-1747 -COMMA- denotes ,
T14785 1741-1746 NN denotes c-Jun
T14784 1737-1740 CC denotes and
T14783 1733-1736 NN denotes JNK
T14782 1730-1732 IN denotes of
T14781 1714-1729 NN denotes phosphorylation
T14780 1712-1713 -COMMA- denotes ,
T14779 1707-1712 NN denotes death
T14778 1702-1706 NN denotes cell
T14777 1692-1701 VB denotes promoting
T14776 1689-1691 IN denotes in
T14775 1682-1688 JJ denotes active
T14774 1677-1681 RB denotes less
T14773 1663-1676 RB denotes significantly
T14772 1658-1662 VB denotes were
T14771 1651-1657 NN denotes Thr308
T14770 1648-1650 IN denotes of
T14769 1640-1647 NN denotes mutants
T14768 1636-1639 NN denotes Asp
T14767 1632-1635 CC denotes and
T14766 1628-1631 NN denotes Ala
T14765 1623-1627 CC denotes both
T14764 1621-1622 -COMMA- denotes ,
T14763 1611-1621 RB denotes Strikingly
T14762 1608-1609 -RRB- denotes ]
T14761 1606-1608 CD denotes 39
T14760 1605-1606 -LRB- denotes [
T14759 1598-1604 NN denotes Thr308
T14758 1584-1597 VB denotes phosphorylate
T14757 1581-1583 TO denotes to
T14756 1576-1580 NN denotes PDK1
T14755 1572-1575 IN denotes for
T14754 1567-1571 NN denotes site
T14753 1559-1566 NN denotes docking
T14752 1557-1558 DT denotes a
T14751 1549-1556 VB denotes provide
T14750 1545-1548 CC denotes and
T14749 1530-1544 VB denotes phosphorylated
T14748 1527-1529 VB denotes be
T14747 1524-1526 TO denotes to
T14746 1519-1523 NN denotes site
T14745 1515-1518 CD denotes 473
T14744 1507-1514 VB denotes mutated
T14743 1503-1506 NNP denotes Ala
T14742 1499-1502 DT denotes the
T14741 1496-1498 IN denotes of
T14740 1486-1495 NN denotes inability
T14739 1482-1485 DT denotes the
T14738 1479-1481 TO denotes to
T14737 1475-1478 JJ denotes due
T14736 1466-1474 RB denotes possibly
T14735 1459-1465 NN denotes Thr308
T14734 1456-1458 IN denotes on
T14733 1441-1455 VB denotes phosphorylated
T14732 1429-1440 RB denotes efficiently
T14731 1426-1428 VB denotes be
T14730 1423-1425 TO denotes to
T14729 1416-1422 JJ denotes unable
T14728 1412-1415 VB denotes was
T14727 1406-1411 NN denotes S473A
T14726 1393-1404 NN denotes necroptosis
T14725 1390-1392 IN denotes of
T14724 1382-1389 NN denotes aspects
T14723 1378-1381 DT denotes all
T14722 1375-1377 IN denotes in
T14721 1368-1374 JJ denotes active
T14720 1363-1367 RB denotes less
T14719 1349-1362 RB denotes significantly
T14718 1345-1348 VB denotes was
T14717 1339-1344 NN denotes S473A
T14716 1333-1338 IN denotes while
T14715 1331-1332 -COMMA- denotes ,
T14714 1323-1331 NN denotes activity
T14713 1315-1322 VB denotes reduced
T14712 1306-1314 RB denotes slightly
T14711 1301-1305 RB denotes only
T14710 1291-1300 VB denotes displayed
T14709 1289-1290 -COMMA- denotes ,
T14708 1285-1289 NN denotes zVAD
T14707 1282-1284 IN denotes of
T14706 1273-1281 NN denotes addition
T14705 1269-1272 DT denotes the
T14704 1263-1268 IN denotes after
T14703 1256-1262 NN denotes Thr308
T14702 1253-1255 IN denotes on
T14701 1238-1252 VB denotes phosphorylated
T14700 1234-1237 VB denotes was
T14699 1228-1233 WDT denotes which
T14698 1226-1227 -COMMA- denotes ,
T14697 1220-1226 NN denotes mutant
T14696 1214-1219 NN denotes S473D
T14695 1210-1213 DT denotes the
T14694 1208-1209 -COMMA- denotes ,
T14693 1200-1208 VB denotes expected
T14692 1197-1199 IN denotes As
T14691 1194-1195 -RRB- denotes )
T14690 1193-1194 NN denotes G
T14689 1192-1193 -COMMA- denotes ,
T14688 1191-1192 NN denotes F
T14687 1190-1191 -COMMA- denotes ,
T14686 1188-1190 NNP denotes 7E
T14685 1183-1187 NNP denotes Fig.
T14684 1182-1183 -LRB- denotes (
T14683 1174-1181 NN denotes changes
T14682 1162-1173 JJ denotes necroptotic
T14681 1154-1161 VB denotes promote
T14680 1151-1153 TO denotes to
T14679 1143-1150 NN denotes ability
T14678 1137-1142 PRP-DOLLAR- denotes their
T14677 1134-1136 IN denotes in
T14676 1122-1133 NN denotes differences
T14675 1116-1121 JJ denotes major
T14674 1106-1115 VB denotes displayed
T14673 1098-1105 NN denotes mutants
T14672 1091-1097 NN denotes Ser473
T14671 1087-1090 CC denotes and
T14670 1080-1086 NN denotes Thr308
T14669 1078-1079 -COMMA- denotes ,
T14668 1068-1078 NN denotes activities
T14667 1058-1067 JJ denotes catalytic
T14666 1050-1057 JJ denotes similar
T14665 1042-1049 IN denotes Despite
T14664 1039-1040 -RRB- denotes )
T14663 1036-1039 NN denotes S8C
T14662 1031-1035 NN denotes Fig.
T14661 1030-1031 -LRB- denotes (
T14660 1021-1029 NN denotes activity
T14659 1018-1020 IN denotes in
T14658 1008-1017 NN denotes decreases
T14657 997-1007 JJ denotes comparable
T14656 987-996 VB denotes displayed
T14655 979-986 NN denotes mutants
T14654 975-978 NN denotes Ala
T14653 970-974 DT denotes both
T14652 964-969 IN denotes while
T14651 962-963 -COMMA- denotes ,
T14650 959-962 NN denotes Akt
T14649 954-958 NN denotes type
T14648 949-953 JJ denotes wild
T14647 946-948 TO denotes to
T14646 935-945 JJ denotes comparable
T14645 926-934 NN denotes activity
T14644 916-925 VB denotes displayed
T14643 908-915 NN denotes mutants
T14642 904-907 NN denotes Asp
T14641 899-903 DT denotes both
T14640 897-898 -COMMA- denotes ,
T14639 892-897 NN denotes hands
T14638 888-891 PRP-DOLLAR- denotes our
T14637 885-887 IN denotes In
T14636 872-883 NN denotes necroptosis
T14635 865-871 IN denotes during
T14602 693-699 NN denotes Thr308
T14601 690-692 IN denotes at
T14600 680-689 NN denotes mutations
T14599 676-679 NN denotes Ala
T14598 671-675 IN denotes that
T14597 662-670 VB denotes reported
T14596 657-661 VB denotes been
T14595 653-656 VB denotes has
T14594 650-652 PRP denotes It
T14593 645-649 NNP denotes Akt.
T14592 642-644 IN denotes of
T14591 632-641 NN denotes functions
T14590 620-631 JJ denotes necroptotic
T14589 616-619 DT denotes the
T14588 613-615 IN denotes of
T14587 602-612 NN denotes regulation
T14586 598-601 DT denotes the
T14585 595-597 IN denotes in
T14584 579-594 NN denotes phosphorylation
T14583 572-578 NN denotes Thr308
T14582 568-571 IN denotes for
T14581 563-567 NN denotes role
T14580 554-562 JJ denotes critical
T14579 550-553 CC denotes and
T14578 541-549 JJ denotes specific
T14577 539-540 DT denotes a
T14576 533-538 VB denotes found
T14575 530-532 PRP denotes we
T14574 528-529 -COMMA- denotes ,
T14573 522-528 RB denotes Second
T14572 519-520 -RRB- denotes )
T14571 518-519 NN denotes B
T14570 517-518 -COMMA- denotes ,
T14569 514-517 NN denotes S8A
T14568 509-513 NNP denotes Fig.
T14567 508-509 -LRB- denotes (
T14566 497-507 NN denotes conditions
T14565 492-496 JJ denotes free
T14564 486-491 NN denotes serum
T14563 480-485 IN denotes under
T14562 471-479 NN denotes addition
T14561 462-470 NN denotes zVAD.fmk
T14560 452-461 VB denotes following
T14559 436-451 NN denotes phosphorylation
T14558 429-435 NN denotes Thr308
T14557 419-428 VB denotes increased
T14556 416-418 CC denotes or
T14555 410-415 NN denotes death
T14554 405-409 NN denotes cell
T14553 402-404 IN denotes of
T14552 391-401 NN denotes activation
T14551 387-390 DT denotes the
T14550 379-386 VB denotes support
T14549 375-378 RB denotes not
T14548 371-374 VB denotes did
T14547 367-370 NN denotes tag
T14546 363-366 NN denotes Myr
T14545 359-362 DT denotes the
T14544 355-358 CC denotes and
T14543 348-354 NN denotes domain
T14542 345-347 NN denotes PH
T14541 341-344 DT denotes the
T14540 336-340 CC denotes both
T14539 328-335 VB denotes lacking
T14538 321-327 NN denotes mutant
T14537 319-320 DT denotes a
T14536 316-318 CC denotes or
T14535 312-315 NN denotes Akt
T14534 305-311 NN denotes length
T14533 300-304 JJ denotes Full
T14532 290-298 VB denotes required
T14531 287-289 VB denotes is
T14530 283-286 NN denotes Akt
T14529 280-282 IN denotes of
T14528 267-279 NN denotes localization
T14527 258-266 NN denotes membrane
T14526 253-257 IN denotes that
T14525 247-252 VB denotes found
T14524 244-246 PRP denotes we
T14523 242-243 -COMMA- denotes ,
T14522 237-242 RB denotes First
T14521 224-235 NN denotes necroptosis
T14520 221-223 IN denotes on
T14519 211-220 NN denotes mutations
T14518 207-210 NN denotes Akt
T14517 201-206 JJ denotes other
T14516 198-200 IN denotes of
T14515 190-197 NN denotes effects
T14514 186-189 DT denotes the
T14513 178-185 VB denotes examine
T14512 175-177 TO denotes to
T14511 172-174 PRP denotes us
T14510 164-171 VB denotes allowed
T14509 159-163 DT denotes This
T14508 150-158 NNP denotes Myr-Akt.
T14507 140-149 VB denotes expressed
T14506 135-139 NN denotes over
T14505 131-134 DT denotes the
T14504 128-130 IN denotes on
T14503 118-127 JJ denotes dependent
T14502 113-117 VB denotes were
T14501 111-112 -RRB- denotes )
T14500 101-111 NN denotes production
T14499 96-100 NN denotes TNFα
T14498 94-95 -COMMA- denotes ,
T14497 84-94 NN denotes activation
T14496 80-83 NN denotes JNK
T14495 78-79 -COMMA- denotes ,
T14494 73-78 NN denotes death
T14493 68-72 NN denotes cell
T14492 67-68 -LRB- denotes (
T14491 60-66 NN denotes events
T14490 49-59 JJ denotes downstream
T14489 32-48 JJ denotes zVAD.fmk-induced
T14488 28-31 DT denotes all
T14487 17-27 NN denotes conditions
T14486 12-16 JJ denotes free
T14485 6-11 NN denotes serum
T14484 0-5 IN denotes Under
T14859 2175-2184 VB denotes including
T14858 2170-2174 NN denotes zVAD
T14857 2167-2169 IN denotes of
T14856 2158-2166 NN denotes presence
T14855 2154-2157 DT denotes the
T14854 2151-2153 IN denotes in
T14853 2141-2150 NN denotes construct
T14852 2133-2140 JJ denotes Myr-Akt
T14851 2129-2132 DT denotes the
T14634 859-864 NN denotes sites
T14633 854-858 DT denotes both
T14632 851-853 IN denotes at
T14631 843-850 NN denotes mutants
T14630 839-842 NN denotes Asp
T14629 835-838 CC denotes and
T14628 831-834 NN denotes Ala
T14627 828-830 IN denotes of
T14626 821-827 NN denotes effect
T14625 817-820 DT denotes the
T14624 808-816 VB denotes examined
T14623 805-807 PRP denotes We
T14622 802-803 -RRB- denotes ]
T14621 800-802 CD denotes 38
T14620 799-800 -LRB- denotes [
T14619 790-798 NN denotes activity
T14618 781-789 VB denotes increase
T14617 773-780 NN denotes mutants
T14616 769-772 NN denotes Asp
T14615 763-768 IN denotes while
T14614 761-762 -COMMA- denotes ,
T14613 758-761 NN denotes Akt
T14612 755-757 IN denotes of
T14611 746-754 NN denotes activity
T14610 736-745 JJ denotes catalytic
T14609 732-735 DT denotes the
T14608 729-731 IN denotes in
T14607 719-728 NN denotes reduction
T14606 717-718 DT denotes a
T14605 711-716 VB denotes cause
T14604 704-710 NN denotes Ser473
T14603 700-703 CC denotes and
T14873 2232-2237 NN denotes model
R9467 T14487 T14484 arg2Of conditions,Under
R9468 T14487 T14485 arg1Of conditions,serum
R9469 T14487 T14486 arg1Of conditions,free
R9470 T14491 T14488 arg1Of events,all
R9471 T14491 T14489 arg1Of events,zVAD.fmk-induced
R9472 T14491 T14490 arg1Of events,downstream
R9473 T14491 T14492 arg1Of events,(
R9474 T14491 T14502 arg1Of events,were
R9475 T14491 T14503 arg1Of events,dependent
R9476 T14494 T14492 arg2Of death,(
R9477 T14494 T14493 arg1Of death,cell
R9478 T14494 T14495 arg1Of death,","
R9479 T14494 T14498 arg1Of death,","
R9480 T14497 T14495 arg2Of activation,","
R9481 T14497 T14496 arg1Of activation,JNK
R9482 T14500 T14498 arg2Of production,","
R9483 T14500 T14499 arg1Of production,TNFα
R9484 T14501 T14492 arg3Of ),(
R9485 T14502 T14484 arg1Of were,Under
R9486 T14502 T14504 arg1Of were,on
R9487 T14503 T14502 arg2Of dependent,were
R9488 T14506 T14505 arg1Of over,the
R9489 T14506 T14507 arg1Of over,expressed
R9490 T14507 T14504 arg2Of expressed,on
R9491 T14508 T14507 arg2Of Myr-Akt.,expressed
R9492 T14508 T14510 arg1Of Myr-Akt.,allowed
R9493 T14510 T14507 arg3Of allowed,expressed
R9494 T14510 T14509 arg1Of allowed,This
R9495 T14511 T14510 arg2Of us,allowed
R9496 T14511 T14513 arg1Of us,examine
R9497 T14513 T14510 arg3Of examine,allowed
R9498 T14513 T14512 arg1Of examine,to
R9499 T14515 T14513 arg2Of effects,examine
R9500 T14515 T14514 arg1Of effects,the
R9501 T14515 T14516 arg1Of effects,of
R9502 T14515 T14520 arg1Of effects,on
R9503 T14519 T14516 arg2Of mutations,of
R9504 T14519 T14517 arg1Of mutations,other
R9505 T14519 T14518 arg1Of mutations,Akt
R9506 T14521 T14520 arg2Of necroptosis,on
R9507 T14524 T14525 arg1Of we,found
R9508 T14525 T14522 arg1Of found,First
R9509 T14525 T14523 arg1Of found,","
R9510 T14528 T14527 arg1Of localization,membrane
R9511 T14528 T14529 arg1Of localization,of
R9512 T14528 T14531 arg1Of localization,is
R9513 T14528 T14532 arg2Of localization,required
R9514 T14530 T14529 arg2Of Akt,of
R9515 T14532 T14525 arg2Of required,found
R9516 T14532 T14526 arg1Of required,that
R9517 T14532 T14531 arg2Of required,is
R9518 T14535 T14533 arg1Of Akt,Full
R9519 T14535 T14534 arg1Of Akt,length
R9520 T14535 T14536 arg1Of Akt,or
R9521 T14536 T14548 arg1Of or,did
R9522 T14536 T14550 arg1Of or,support
R9523 T14538 T14536 arg2Of mutant,or
R9524 T14538 T14537 arg1Of mutant,a
R9525 T14538 T14539 arg1Of mutant,lacking
R9526 T14543 T14541 arg1Of domain,the
R9527 T14543 T14542 arg1Of domain,PH
R9528 T14543 T14544 arg1Of domain,and
R9529 T14544 T14539 arg2Of and,lacking
R9530 T14544 T14540 arg1Of and,both
R9531 T14547 T14544 arg2Of tag,and
R9532 T14547 T14545 arg1Of tag,the
R9533 T14547 T14546 arg1Of tag,Myr
R9534 T14550 T14548 arg2Of support,did
R9535 T14550 T14549 arg1Of support,not
R9536 T14550 T14560 arg1Of support,following
R9537 T14552 T14550 arg2Of activation,support
R9538 T14552 T14551 arg1Of activation,the
R9539 T14552 T14553 arg1Of activation,of
R9540 T14555 T14554 arg1Of death,cell
R9541 T14555 T14556 arg1Of death,or
R9542 T14556 T14553 arg2Of or,of
R9543 T14559 T14556 arg2Of phosphorylation,or
R9544 T14559 T14557 arg2Of phosphorylation,increased
R9545 T14559 T14558 arg1Of phosphorylation,Thr308
R9546 T14562 T14560 arg2Of addition,following
R9547 T14562 T14561 arg1Of addition,zVAD.fmk
R9548 T14562 T14563 arg1Of addition,under
R9549 T14566 T14563 arg2Of conditions,under
R9550 T14566 T14564 arg1Of conditions,serum
R9551 T14566 T14565 arg1Of conditions,free
R9552 T14566 T14567 arg1Of conditions,(
R9553 T14569 T14567 arg2Of S8A,(
R9554 T14569 T14568 arg1Of S8A,Fig.
R9555 T14569 T14570 arg1Of S8A,","
R9556 T14571 T14570 arg2Of B,","
R9557 T14572 T14567 arg3Of ),(
R9558 T14575 T14576 arg1Of we,found
R9559 T14578 T14579 arg1Of specific,and
R9560 T14580 T14579 arg2Of critical,and
R9561 T14581 T14577 arg1Of role,a
R9562 T14581 T14578 arg1Of role,specific
R9563 T14581 T14580 arg1Of role,critical
R9564 T14581 T14582 arg1Of role,for
R9565 T14581 T14585 arg1Of role,in
R9566 T14581 T14595 arg1Of role,has
R9567 T14581 T14596 arg1Of role,been
R9568 T14581 T14597 arg2Of role,reported
R9569 T14584 T14582 arg2Of phosphorylation,for
R9570 T14584 T14583 arg1Of phosphorylation,Thr308
R9571 T14587 T14585 arg2Of regulation,in
R9572 T14587 T14586 arg1Of regulation,the
R9573 T14587 T14588 arg1Of regulation,of
R9574 T14591 T14588 arg2Of functions,of
R9575 T14591 T14589 arg1Of functions,the
R9576 T14591 T14590 arg1Of functions,necroptotic
R9577 T14591 T14592 arg1Of functions,of
R9578 T14594 T14592 arg2Of It,of
R9579 T14594 T14593 arg1Of It,Akt.
R9580 T14597 T14573 arg1Of reported,Second
R9581 T14597 T14574 arg1Of reported,","
R9582 T14597 T14576 arg2Of reported,found
R9583 T14597 T14595 arg2Of reported,has
R9584 T14597 T14596 arg2Of reported,been
R9585 T14600 T14599 arg1Of mutations,Ala
R9586 T14600 T14601 arg1Of mutations,at
R9587 T14600 T14605 arg1Of mutations,cause
R9588 T14602 T14603 arg1Of Thr308,and
R9589 T14603 T14601 arg2Of and,at
R9590 T14604 T14603 arg2Of Ser473,and
R9591 T14605 T14597 arg3Of cause,reported
R9592 T14605 T14598 arg1Of cause,that
R9593 T14605 T14614 arg1Of cause,","
R9594 T14605 T14615 arg1Of cause,while
R9595 T14607 T14605 arg2Of reduction,cause
R9596 T14607 T14606 arg1Of reduction,a
R9597 T14607 T14608 arg1Of reduction,in
R9598 T14611 T14608 arg2Of activity,in
R9599 T14611 T14609 arg1Of activity,the
R9600 T14611 T14610 arg1Of activity,catalytic
R9601 T14611 T14612 arg1Of activity,of
R9602 T14613 T14612 arg2Of Akt,of
R9603 T14617 T14616 arg1Of mutants,Asp
R9604 T14617 T14618 arg1Of mutants,increase
R9605 T14618 T14615 arg2Of increase,while
R9606 T14619 T14618 arg2Of activity,increase
R9607 T14619 T14620 arg1Of activity,[
R9608 T14621 T14620 arg2Of 38,[
R9609 T14622 T14620 arg3Of ],[
R9610 T14623 T14624 arg1Of We,examined
R9611 T14626 T14624 arg2Of effect,examined
R9612 T14626 T14625 arg1Of effect,the
R9613 T14626 T14627 arg1Of effect,of
R9614 T14626 T14632 arg1Of effect,at
R9615 T14628 T14629 arg1Of Ala,and
R9616 T14630 T14629 arg2Of Asp,and
R9617 T14631 T14627 arg2Of mutants,of
R9618 T14631 T14628 arg1Of mutants,Ala
R9619 T14631 T14630 arg1Of mutants,Asp
R9620 T14634 T14632 arg2Of sites,at
R9621 T14634 T14633 arg1Of sites,both
R9622 T14634 T14635 arg1Of sites,during
R9623 T14636 T14635 arg2Of necroptosis,during
R9624 T14639 T14637 arg2Of hands,In
R9625 T14639 T14638 arg1Of hands,our
R9626 T14643 T14641 arg1Of mutants,both
R9627 T14643 T14642 arg1Of mutants,Asp
R9628 T14643 T14644 arg1Of mutants,displayed
R9629 T14644 T14637 arg1Of displayed,In
R9630 T14644 T14640 arg1Of displayed,","
R9631 T14644 T14651 arg1Of displayed,","
R9632 T14644 T14652 arg1Of displayed,while
R9633 T14645 T14644 arg2Of activity,displayed
R9634 T14645 T14646 arg1Of activity,comparable
R9635 T14646 T14647 arg1Of comparable,to
R9636 T14650 T14647 arg2Of Akt,to
R9637 T14650 T14648 arg1Of Akt,wild
R9638 T14650 T14649 arg1Of Akt,type
R9639 T14655 T14653 arg1Of mutants,both
R9640 T14655 T14654 arg1Of mutants,Ala
R9641 T14655 T14656 arg1Of mutants,displayed
R9642 T14656 T14652 arg2Of displayed,while
R9643 T14658 T14656 arg2Of decreases,displayed
R9644 T14658 T14657 arg1Of decreases,comparable
R9645 T14658 T14659 arg1Of decreases,in
R9646 T14660 T14659 arg2Of activity,in
R9647 T14660 T14661 arg1Of activity,(
R9648 T14663 T14661 arg2Of S8C,(
R9649 T14663 T14662 arg1Of S8C,Fig.
R9650 T14664 T14661 arg3Of ),(
R9651 T14668 T14665 arg2Of activities,Despite
R9652 T14668 T14666 arg1Of activities,similar
R9653 T14668 T14667 arg1Of activities,catalytic
R9654 T14670 T14671 arg1Of Thr308,and
R9655 T14672 T14671 arg2Of Ser473,and
R9656 T14673 T14670 arg1Of mutants,Thr308
R9657 T14673 T14672 arg1Of mutants,Ser473
R9658 T14673 T14674 arg1Of mutants,displayed
R9659 T14674 T14665 arg1Of displayed,Despite
R9660 T14674 T14669 arg1Of displayed,","
R9661 T14674 T14677 arg1Of displayed,in
R9662 T14676 T14674 arg2Of differences,displayed
R9663 T14676 T14675 arg1Of differences,major
R9664 T14679 T14677 arg2Of ability,in
R9665 T14679 T14678 arg1Of ability,their
R9666 T14679 T14680 modOf ability,to
R9667 T14681 T14680 arg1Of promote,to
R9668 T14683 T14681 arg2Of changes,promote
R9669 T14683 T14682 arg1Of changes,necroptotic
R9670 T14683 T14684 arg1Of changes,(
R9671 T14686 T14684 arg2Of 7E,(
R9672 T14686 T14685 arg1Of 7E,Fig.
R9673 T14686 T14687 arg1Of 7E,","
R9674 T14686 T14689 arg1Of 7E,","
R9675 T14688 T14687 arg2Of F,","
R9676 T14690 T14689 arg2Of G,","
R9677 T14691 T14684 arg3Of ),(
R9678 T14693 T14692 arg2Of expected,As
R9679 T14697 T14695 arg1Of mutant,the
R9680 T14697 T14696 arg1Of mutant,S473D
R9681 T14697 T14698 arg1Of mutant,","
R9682 T14697 T14699 arg1Of mutant,which
R9683 T14697 T14700 arg1Of mutant,was
R9684 T14697 T14701 arg2Of mutant,phosphorylated
R9685 T14697 T14710 arg1Of mutant,displayed
R9686 T14701 T14700 arg2Of phosphorylated,was
R9687 T14701 T14702 arg1Of phosphorylated,on
R9688 T14701 T14704 arg1Of phosphorylated,after
R9689 T14703 T14702 arg2Of Thr308,on
R9690 T14706 T14704 arg2Of addition,after
R9691 T14706 T14705 arg1Of addition,the
R9692 T14706 T14707 arg1Of addition,of
R9693 T14708 T14707 arg2Of zVAD,of
R9694 T14710 T14692 arg1Of displayed,As
R9695 T14710 T14694 arg1Of displayed,","
R9696 T14710 T14709 arg1Of displayed,","
R9697 T14710 T14715 arg1Of displayed,","
R9698 T14710 T14716 arg1Of displayed,while
R9699 T14712 T14711 arg1Of slightly,only
R9700 T14713 T14712 arg1Of reduced,slightly
R9701 T14714 T14710 arg2Of activity,displayed
R9702 T14714 T14713 arg1Of activity,reduced
R9703 T14717 T14718 arg1Of S473A,was
R9704 T14717 T14721 arg1Of S473A,active
R9705 T14718 T14716 arg2Of was,while
R9706 T14720 T14719 arg1Of less,significantly
R9707 T14721 T14718 arg2Of active,was
R9708 T14721 T14720 arg1Of active,less
R9709 T14721 T14722 arg1Of active,in
R9710 T14724 T14722 arg2Of aspects,in
R9711 T14724 T14723 arg1Of aspects,all
R9712 T14724 T14725 arg1Of aspects,of
R9713 T14726 T14725 arg2Of necroptosis,of
R9714 T14727 T14728 arg1Of S473A,was
R9715 T14727 T14729 arg1Of S473A,unable
R9716 T14727 T14731 arg1Of S473A,be
R9717 T14727 T14733 arg2Of S473A,phosphorylated
R9718 T14727 T14751 arg1Of S473A,provide
R9719 T14728 T14750 arg1Of was,and
R9720 T14729 T14728 arg2Of unable,was
R9721 T14729 T14738 arg1Of unable,to
R9722 T14733 T14729 arg2Of phosphorylated,unable
R9723 T14733 T14730 arg1Of phosphorylated,to
R9724 T14733 T14731 arg2Of phosphorylated,be
R9725 T14733 T14732 arg1Of phosphorylated,efficiently
R9726 T14733 T14734 arg1Of phosphorylated,on
R9727 T14733 T14736 arg1Of phosphorylated,possibly
R9728 T14735 T14734 arg2Of Thr308,on
R9729 T14738 T14737 arg1Of to,due
R9730 T14740 T14738 arg2Of inability,to
R9731 T14740 T14739 arg1Of inability,the
R9732 T14740 T14741 arg1Of inability,of
R9733 T14740 T14747 modOf inability,to
R9734 T14740 T14748 arg1Of inability,be
R9735 T14740 T14749 arg2Of inability,phosphorylated
R9736 T14746 T14741 arg2Of site,of
R9737 T14746 T14742 arg1Of site,the
R9738 T14746 T14743 arg1Of site,Ala
R9739 T14746 T14744 arg2Of site,mutated
R9740 T14746 T14745 arg1Of site,473
R9741 T14749 T14747 arg1Of phosphorylated,to
R9742 T14749 T14748 arg2Of phosphorylated,be
R9743 T14750 T14760 arg1Of and,[
R9744 T14751 T14750 arg2Of provide,and
R9745 T14754 T14751 arg2Of site,provide
R9746 T14754 T14752 arg1Of site,a
R9747 T14754 T14753 arg1Of site,docking
R9748 T14754 T14755 arg1Of site,for
R9749 T14756 T14755 arg2Of PDK1,for
R9750 T14756 T14758 arg1Of PDK1,phosphorylate
R9751 T14758 T14755 arg3Of phosphorylate,for
R9752 T14758 T14757 arg1Of phosphorylate,to
R9753 T14759 T14758 arg2Of Thr308,phosphorylate
R9754 T14761 T14760 arg2Of 39,[
R9755 T14762 T14760 arg3Of ],[
R9756 T14766 T14767 arg1Of Ala,and
R9757 T14767 T14765 arg1Of and,both
R9758 T14767 T14772 arg1Of and,were
R9759 T14767 T14775 arg1Of and,active
R9760 T14767 T14777 arg1Of and,promoting
R9761 T14769 T14767 arg2Of mutants,and
R9762 T14769 T14768 arg1Of mutants,Asp
R9763 T14769 T14770 arg1Of mutants,of
R9764 T14771 T14770 arg2Of Thr308,of
R9765 T14772 T14763 arg1Of were,Strikingly
R9766 T14772 T14764 arg1Of were,","
R9767 T14774 T14773 arg1Of less,significantly
R9768 T14775 T14772 arg2Of active,were
R9769 T14775 T14774 arg1Of active,less
R9770 T14775 T14776 arg1Of active,in
R9771 T14777 T14776 arg2Of promoting,in
R9772 T14779 T14778 arg1Of death,cell
R9773 T14779 T14780 arg1Of death,","
R9774 T14780 T14784 arg1Of ",",and
R9775 T14781 T14780 arg2Of phosphorylation,","
R9776 T14781 T14782 arg1Of phosphorylation,of
R9777 T14783 T14782 arg2Of JNK,of
R9778 T14784 T14787 arg1Of and,and
R9779 T14785 T14784 arg2Of c-Jun,and
R9780 T14787 T14777 arg2Of and,promoting
R9781 T14787 T14786 arg1Of and,","
R9782 T14789 T14787 arg2Of mRNA,and
R9783 T14789 T14788 arg1Of mRNA,TNFα
R9784 T14790 T14791 arg1Of This,suggests
R9785 T14793 T14804 arg1Of T308D,may
R9786 T14793 T14806 arg1Of T308D,be
R9787 T14796 T14795 arg2Of spite,in
R9788 T14796 T14797 arg1Of spite,of
R9789 T14798 T14797 arg2Of being,of
R9790 T14802 T14798 arg2Of construct,being
R9791 T14802 T14799 arg1Of construct,an
R9792 T14802 T14800 arg1Of construct,active
R9793 T14802 T14801 arg1Of construct,Akt
R9794 T14806 T14794 arg1Of be,","
R9795 T14806 T14795 arg1Of be,in
R9796 T14806 T14803 arg1Of be,","
R9797 T14806 T14804 arg2Of be,may
R9798 T14806 T14805 arg1Of be,not
R9799 T14806 T14812 arg1Of be,and
R9800 T14809 T14806 arg2Of mimic,be
R9801 T14809 T14807 arg1Of mimic,a
R9802 T14809 T14808 arg1Of mimic,perfect
R9803 T14809 T14810 arg1Of mimic,of
R9804 T14811 T14810 arg2Of phosphorylation,of
R9805 T14812 T14791 arg2Of and,suggests
R9806 T14812 T14792 arg1Of and,that
R9807 T14815 T14813 arg1Of form,this
R9808 T14815 T14814 arg1Of form,mutant
R9809 T14815 T14816 arg1Of form,of
R9810 T14815 T14819 arg1Of form,may
R9811 T14815 T14821 arg1Of form,have
R9812 T14818 T14816 arg2Of kinase,of
R9813 T14818 T14817 arg1Of kinase,the
R9814 T14821 T14812 arg2Of have,and
R9815 T14821 T14819 arg2Of have,may
R9816 T14821 T14820 arg1Of have,not
R9817 T14821 T14824 modOf have,to
R9818 T14823 T14821 arg2Of activity,have
R9819 T14823 T14822 arg1Of activity,sufficient
R9820 T14825 T14824 arg1Of phosphorylate,to
R9821 T14828 T14825 arg2Of repertoire,phosphorylate
R9822 T14828 T14826 arg1Of repertoire,the
R9823 T14828 T14827 arg1Of repertoire,entire
R9824 T14828 T14829 arg1Of repertoire,of
R9825 T14828 T14831 arg1Of repertoire,in
R9826 T14830 T14829 arg2Of substrates,of
R9827 T14833 T14831 arg2Of cells,in
R9828 T14833 T14832 arg1Of cells,the
R9829 T14835 T14834 arg2Of tested,When
R9830 T14837 T14838 arg1Of T308D,did
R9831 T14837 T14840 arg1Of T308D,support
R9832 T14840 T14834 arg1Of support,When
R9833 T14840 T14836 arg1Of support,","
R9834 T14840 T14838 arg2Of support,did
R9835 T14840 T14839 arg1Of support,not
R9836 T14843 T14840 arg2Of phosphorylation,support
R9837 T14843 T14841 arg1Of phosphorylation,the
R9838 T14843 T14842 arg1Of phosphorylation,downstream
R9839 T14843 T14844 arg1Of phosphorylation,of
R9840 T14846 T14844 arg2Of substrates,of
R9841 T14846 T14845 arg1Of substrates,several
R9842 T14846 T14847 arg1Of substrates,that
R9843 T14846 T14848 arg1Of substrates,were
R9844 T14846 T14849 arg2Of substrates,phosphorylated
R9845 T14849 T14848 arg2Of phosphorylated,were
R9846 T14853 T14849 arg1Of construct,phosphorylated
R9847 T14853 T14850 arg2Of construct,by
R9848 T14853 T14851 arg1Of construct,the
R9849 T14853 T14852 arg1Of construct,Myr-Akt
R9850 T14853 T14854 arg1Of construct,in
R9851 T14856 T14854 arg2Of presence,in
R9852 T14856 T14855 arg1Of presence,the
R9853 T14856 T14857 arg1Of presence,of
R9854 T14858 T14857 arg2Of zVAD,of
R9855 T14858 T14859 arg1Of zVAD,including
R9856 T14860 T14861 arg1Of FoxO1,","
R9857 T14861 T14863 arg1Of ",",","
R9858 T14862 T14861 arg2Of Foxo4,","
R9859 T14863 T14866 arg1Of ",",and
R9860 T14864 T14863 arg2Of MDM2,","
R9861 T14866 T14859 arg2Of and,including
R9862 T14866 T14865 arg1Of and,","
R9863 T14867 T14866 arg2Of p70S6K,and
R9864 T14867 T14868 arg1Of p70S6K,(
R9865 T14870 T14868 arg2Of S8D,(
R9866 T14870 T14869 arg1Of S8D,Fig.
R9867 T14871 T14868 arg3Of ),(
R9868 T14873 T14872 arg1Of model,Our
R9869 T14873 T14874 arg1Of model,","
R9870 T14873 T14875 arg1Of model,based
R9871 T14873 T14880 arg1Of model,is
R9872 T14876 T14875 arg2Of on,based
R9873 T14878 T14876 arg2Of results,on
R9874 T14878 T14877 arg1Of results,these
R9875 T14880 T14879 arg1Of is,","
R9876 T14884 T14882 arg1Of phosphorylation,necroptosis-specific
R9877 T14884 T14883 arg1Of phosphorylation,Thr308
R9878 T14884 T14885 arg1Of phosphorylation,provides
R9879 T14884 T14904 arg1Of phosphorylation,promote
R9880 T14885 T14895 arg1Of provides,","
R9881 T14885 T14896 modOf provides,allowing
R9882 T14885 T14903 arg1Of provides,","
R9883 T14888 T14885 arg2Of link,provides
R9884 T14888 T14886 arg1Of link,a
R9885 T14888 T14887 arg1Of link,critical
R9886 T14888 T14889 arg1Of link,between
R9887 T14891 T14890 arg1Of machinery,necroptotic
R9888 T14891 T14892 arg1Of machinery,and
R9889 T14892 T14889 arg2Of and,between
R9890 T14894 T14892 arg2Of kinase,and
R9891 T14894 T14893 arg1Of kinase,Akt
R9892 T14897 T14896 arg2Of Akt,allowing
R9893 T14897 T14899 arg1Of Akt,phosphorylate
R9894 T14899 T14896 arg3Of phosphorylate,allowing
R9895 T14899 T14898 arg1Of phosphorylate,to
R9896 T14899 T14901 arg1Of phosphorylate,during
R9897 T14900 T14899 arg2Of substrates,phosphorylate
R9898 T14902 T14901 arg2Of necroptosis,during
R9899 T14903 T14880 arg2Of ",",is
R9900 T14903 T14881 arg1Of ",",that
R9901 T14904 T14903 arg2Of promote,","
R9902 T14906 T14905 arg1Of synthesis,TNFα
R9903 T14906 T14907 arg1Of synthesis,","
R9904 T14907 T14910 arg1Of ",",and
R9905 T14909 T14907 arg2Of activation,","
R9906 T14909 T14908 arg1Of activation,JNK
R9907 T14910 T14904 arg2Of and,promote
R9908 T14913 T14910 arg2Of death,and
R9909 T14913 T14911 arg1Of death,eventual
R9910 T14913 T14912 arg1Of death,cell

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T13834 1214-1226 Antecedent denotes S473D mutant
T13833 1228-1233 Anaphor denotes which
T13832 970-974 Anaphor denotes both
T13831 854-864 Antecedent denotes both sites
T13830 899-903 Anaphor denotes both
R9039 T13830 T13831 boundBy both,both sites
R9040 T13832 T13831 boundBy both,both sites
R9041 T13833 T13834 boundBy which,S473D mutant

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T13877 2455-2459 Protein denotes TNFα
T13876 2209-2215 Protein denotes p70S6K
T13875 2199-2203 Protein denotes MDM2
T13874 2192-2197 Protein denotes Foxo4
T13873 2185-2190 Protein denotes FoxO1
T13872 2133-2140 Protein denotes Myr-Akt
T13871 2026-2031 Protein denotes T308D
T13870 1782-1787 Protein denotes T308D
T13869 1752-1756 Protein denotes TNFα
T13868 1741-1746 Protein denotes c-Jun
T13867 1576-1580 Protein denotes PDK1
T13866 1406-1411 Protein denotes S473A
T13865 1339-1344 Protein denotes S473A
T13864 1214-1226 Protein denotes S473D mutant
T13863 758-761 Protein denotes Akt
T13862 150-157 Protein denotes Myr-Akt
T13861 96-100 Protein denotes TNFα

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T15053 2395-2398 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15052 2374-2377 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15051 2137-2140 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15050 1817-1820 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15049 959-962 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15048 758-761 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15047 645-648 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15046 312-315 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15045 283-286 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15044 207-210 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15043 154-157 http://www.uniprot.org/uniprot/P31751 denotes Akt
T15018 2395-2398 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15017 2374-2377 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15016 2137-2140 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15015 1817-1820 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15014 959-962 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15013 758-761 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15012 645-648 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15011 312-315 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15010 283-286 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15009 207-210 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15008 154-157 http://www.uniprot.org/uniprot/P31749 denotes Akt
T15100 2185-2190 http://www.uniprot.org/uniprot/Q12778 denotes FoxO1
T15098 2455-2459 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T15097 1752-1756 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T15096 96-100 http://www.uniprot.org/uniprot/P01375 denotes TNFα
T15094 1741-1746 http://www.uniprot.org/uniprot/P05412 denotes c-Jun
T15088 2395-2398 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15087 2374-2377 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15086 2137-2140 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15085 1817-1820 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15084 959-962 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15083 758-761 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15082 645-648 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15081 312-315 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15080 283-286 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15079 207-210 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T15078 154-157 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt

UBERON-AE

Id Subject Object Predicate Lexical cue
T13695 486-491 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T13694 6-11 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum

GO-BP

Id Subject Object Predicate Lexical cue
T13955 2460-2469 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T13954 1576-1580 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T13953 1058-1078 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activities
T13952 736-754 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T13951 602-612 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T13950 579-612 http://purl.obolibrary.org/obo/GO_0042325 denotes phosphorylation in the regulation
T13949 391-415 http://purl.obolibrary.org/obo/GO_1904094 denotes activation of cell death
T13948 391-415 http://purl.obolibrary.org/obo/GO_0043068 denotes activation of cell death
T13947 391-415 http://purl.obolibrary.org/obo/GO_0071888 denotes activation of cell death
T13946 391-415 http://purl.obolibrary.org/obo/GO_1901216 denotes activation of cell death
T13945 391-409 http://purl.obolibrary.org/obo/GO_0001775 denotes activation of cell
T13943 258-279 http://purl.obolibrary.org/obo/GO_0051668 denotes membrane localization
T13941 2471-2474 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13940 1733-1736 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13939 80-83 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13937 2299-2314 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13936 2063-2078 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13935 1862-1877 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13934 1714-1729 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13933 579-594 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13932 436-451 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T13925 2504-2509 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13924 1707-1712 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13923 410-415 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13922 73-78 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T13919 2499-2509 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13918 1702-1712 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13917 405-415 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13916 68-78 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T13913 267-279 http://purl.obolibrary.org/obo/GO_0051179 denotes localization
T13905 2434-2445 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13904 2271-2282 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13903 1393-1404 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13902 872-883 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13901 224-235 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T13891 2434-2445 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13890 2271-2282 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13889 1393-1404 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13888 872-883 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T13887 224-235 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis

GO-MF

Id Subject Object Predicate Lexical cue
T13963 1576-1580 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T13962 1058-1078 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activities
T13961 736-754 http://purl.obolibrary.org/obo/GO_0003824 denotes catalytic activity
T13959 2471-2474 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13958 1733-1736 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK
T13957 80-83 http://purl.obolibrary.org/obo/GO_0004705 denotes JNK

GO-CC

Id Subject Object Predicate Lexical cue
T13973 258-266 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T13969 2499-2503 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T13968 2006-2011 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T13722 2228-2510 Sentence denotes Our model, based on these results, is that necroptosis-specific Thr308 phosphorylation provides a critical link between necroptotic machinery and Akt kinase, allowing Akt to phosphorylate substrates during necroptosis, promote TNFα synthesis, JNK activation and eventual cell death.
T13721 2013-2227 Sentence denotes When tested, T308D did not support the downstream phosphorylation of several substrates that were phosphorylated by the Myr-Akt construct in the presence of zVAD including FoxO1, Foxo4, MDM2, and p70S6K (Fig. S8D).
T13720 1763-2012 Sentence denotes This suggests that T308D, in spite of being an active Akt construct, may not be a perfect mimic of phosphorylation and this mutant form of the kinase may not have sufficient activity to phosphorylate the entire repertoire of substrates in the cells.
T13719 1611-1762 Sentence denotes Strikingly, both Ala and Asp mutants of Thr308 were significantly less active in promoting cell death, phosphorylation of JNK and c-Jun, and TNFα mRNA.
T13718 1406-1610 Sentence denotes S473A was unable to be efficiently phosphorylated on Thr308 possibly due to the inability of the Ala mutated 473 site to be phosphorylated and provide a docking site for PDK1 to phosphorylate Thr308 [39].
T13717 1197-1405 Sentence denotes As expected, the S473D mutant, which was phosphorylated on Thr308 after the addition of zVAD, displayed only slightly reduced activity, while S473A was significantly less active in all aspects of necroptosis.
T13716 1042-1196 Sentence denotes Despite similar catalytic activities, Thr308 and Ser473 mutants displayed major differences in their ability to promote necroptotic changes (Fig. 7E,F,G).
T13715 885-1041 Sentence denotes In our hands, both Asp mutants displayed activity comparable to wild type Akt, while both Ala mutants displayed comparable decreases in activity (Fig. S8C).
T13714 805-884 Sentence denotes We examined the effect of Ala and Asp mutants at both sites during necroptosis.
T13713 522-804 Sentence denotes Second, we found a specific and critical role for Thr308 phosphorylation in the regulation of the necroptotic functions of Akt. It has been reported that Ala mutations at Thr308 and Ser473 cause a reduction in the catalytic activity of Akt, while Asp mutants increase activity [38].
T13712 300-521 Sentence denotes Full length Akt or a mutant lacking both the PH domain and the Myr tag did not support the activation of cell death or increased Thr308 phosphorylation following zVAD.fmk addition under serum free conditions (Fig. S8A,B).
T13711 237-299 Sentence denotes First, we found that membrane localization of Akt is required.
T13710 0-236 Sentence denotes Under serum free conditions all zVAD.fmk-induced downstream events (cell death, JNK activation, TNFα production) were dependent on the over expressed Myr-Akt. This allowed us to examine the effects of other Akt mutations on necroptosis.
T198 0-158 Sentence denotes Under serum free conditions all zVAD.fmk-induced downstream events (cell death, JNK activation, TNFα production) were dependent on the over expressed Myr-Akt.
T199 159-236 Sentence denotes This allowed us to examine the effects of other Akt mutations on necroptosis.
T200 237-299 Sentence denotes First, we found that membrane localization of Akt is required.
T201 300-521 Sentence denotes Full length Akt or a mutant lacking both the PH domain and the Myr tag did not support the activation of cell death or increased Thr308 phosphorylation following zVAD.fmk addition under serum free conditions (Fig. S8A,B).
T202 522-649 Sentence denotes Second, we found a specific and critical role for Thr308 phosphorylation in the regulation of the necroptotic functions of Akt.
T203 650-804 Sentence denotes It has been reported that Ala mutations at Thr308 and Ser473 cause a reduction in the catalytic activity of Akt, while Asp mutants increase activity [38].
T204 805-884 Sentence denotes We examined the effect of Ala and Asp mutants at both sites during necroptosis.
T205 885-1041 Sentence denotes In our hands, both Asp mutants displayed activity comparable to wild type Akt, while both Ala mutants displayed comparable decreases in activity (Fig. S8C).
T206 1042-1196 Sentence denotes Despite similar catalytic activities, Thr308 and Ser473 mutants displayed major differences in their ability to promote necroptotic changes (Fig. 7E,F,G).
T207 1197-1405 Sentence denotes As expected, the S473D mutant, which was phosphorylated on Thr308 after the addition of zVAD, displayed only slightly reduced activity, while S473A was significantly less active in all aspects of necroptosis.
T208 1406-1610 Sentence denotes S473A was unable to be efficiently phosphorylated on Thr308 possibly due to the inability of the Ala mutated 473 site to be phosphorylated and provide a docking site for PDK1 to phosphorylate Thr308 [39].
T209 1611-1762 Sentence denotes Strikingly, both Ala and Asp mutants of Thr308 were significantly less active in promoting cell death, phosphorylation of JNK and c-Jun, and TNFα mRNA.
T210 1763-2012 Sentence denotes This suggests that T308D, in spite of being an active Akt construct, may not be a perfect mimic of phosphorylation and this mutant form of the kinase may not have sufficient activity to phosphorylate the entire repertoire of substrates in the cells.
T211 2013-2227 Sentence denotes When tested, T308D did not support the downstream phosphorylation of several substrates that were phosphorylated by the Myr-Akt construct in the presence of zVAD including FoxO1, Foxo4, MDM2, and p70S6K (Fig. S8D).
T212 2228-2510 Sentence denotes Our model, based on these results, is that necroptosis-specific Thr308 phosphorylation provides a critical link between necroptotic machinery and Akt kinase, allowing Akt to phosphorylate substrates during necroptosis, promote TNFα synthesis, JNK activation and eventual cell death.

simple1

Id Subject Object Predicate Lexical cue
T14060 2455-2459 Protein denotes TNFα
T14059 2209-2215 Protein denotes p70S6K
T14058 2199-2203 Protein denotes MDM2
T14057 2192-2197 Protein denotes Foxo4
T14056 2185-2190 Protein denotes FoxO1
T14055 2133-2140 Protein denotes Myr-Akt
T14054 2026-2031 Protein denotes T308D
T14053 1782-1787 Protein denotes T308D
T14052 1752-1756 Protein denotes TNFα
T14051 1741-1746 Protein denotes c-Jun
T14050 1576-1580 Protein denotes PDK1
T14049 1406-1411 Protein denotes S473A
T14048 1339-1344 Protein denotes S473A
T14047 1214-1226 Protein denotes S473D mutant
T14046 758-761 Protein denotes Akt
T14045 150-157 Protein denotes Myr-Akt
T14044 96-100 Protein denotes TNFα

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T14983 2460-2469 Gene_expression denotes synthesis
T14982 2447-2454 Positive_regulation denotes promote
T14981 2170-2174 Negative_regulation denotes zVAD
T14980 2111-2125 Phosphorylation denotes phosphorylated
T14979 1862-1877 Phosphorylation denotes phosphorylation
T14978 1714-1729 Phosphorylation denotes phosphorylation
T14977 1692-1701 Positive_regulation denotes promoting
T14976 1441-1455 Phosphorylation denotes phosphorylated
T14975 1368-1374 Gene_expression denotes active
T14974 1238-1252 Phosphorylation denotes phosphorylated
T14973 719-728 Negative_regulation denotes reduction
T14972 140-149 Gene_expression denotes expressed
T14971 101-111 Gene_expression denotes production
T14956 2455-2459 Protein denotes TNFα
T14955 2209-2215 Protein denotes p70S6K
T14954 2199-2203 Protein denotes MDM2
T14953 2192-2197 Protein denotes Foxo4
T14952 2185-2190 Protein denotes FoxO1
T14951 2133-2140 Protein denotes Myr-Akt
T14950 2026-2031 Protein denotes T308D
T14949 1782-1787 Protein denotes T308D
T14948 1752-1756 Protein denotes TNFα
T14947 1741-1746 Protein denotes c-Jun
T14946 1576-1580 Protein denotes PDK1
T14945 1406-1411 Protein denotes S473A
T14944 1339-1344 Protein denotes S473A
T14943 1214-1226 Protein denotes S473D mutant
T14942 758-761 Protein denotes Akt
T14941 150-157 Protein denotes Myr-Akt
T14940 96-100 Protein denotes TNFα
R9929 T14940 T14971 themeOf TNFα,production
R9930 T14941 T14972 themeOf Myr-Akt,expressed
R9931 T14942 T14973 themeOf Akt,reduction
R9932 T14943 T14974 themeOf S473D mutant,phosphorylated
R9933 T14944 T14975 themeOf S473A,active
R9934 T14945 T14976 themeOf S473A,phosphorylated
R9935 T14947 T14978 themeOf c-Jun,phosphorylation
R9936 T14948 T14977 themeOf TNFα,promoting
R9937 T14949 T14979 themeOf T308D,phosphorylation
R9938 T14953 T14980 themeOf Foxo4,phosphorylated
R9939 T14953 T14981 themeOf Foxo4,zVAD
R9940 T14956 T14983 themeOf TNFα,synthesis
R9947 T14978 T14977 themeOf phosphorylation,promoting
R9948 T14983 T14982 themeOf synthesis,promote

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T15293 2460-2469 Gene_expression denotes synthesis
T15292 2447-2454 Positive_regulation denotes promote
T15291 1862-1877 Phosphorylation denotes phosphorylation
T15290 1692-1701 Positive_regulation denotes promoting
T15289 1714-1729 Phosphorylation denotes phosphorylation
T15288 1441-1455 Phosphorylation denotes phosphorylated
T15287 1238-1252 Phosphorylation denotes phosphorylated
T15286 719-728 Negative_regulation denotes reduction
T15285 140-149 Gene_expression denotes expressed
T15284 101-111 Gene_expression denotes production
T15259 1406-1411 Protein denotes S473A
T15258 1339-1344 Protein denotes S473A
T15257 1214-1226 Protein denotes S473D mutant
T15256 758-761 Protein denotes Akt
T15255 150-157 Protein denotes Myr-Akt
T15254 96-100 Protein denotes TNFα
T15270 2455-2459 Protein denotes TNFα
T15269 2209-2215 Protein denotes p70S6K
T15268 2199-2203 Protein denotes MDM2
T15267 2192-2197 Protein denotes Foxo4
T15266 2185-2190 Protein denotes FoxO1
T15265 2133-2140 Protein denotes Myr-Akt
T15264 2026-2031 Protein denotes T308D
T15263 1782-1787 Protein denotes T308D
T15262 1752-1756 Protein denotes TNFα
T15261 1741-1746 Protein denotes c-Jun
T15260 1576-1580 Protein denotes PDK1
R10024 T15254 T15284 themeOf TNFα,production
R10025 T15255 T15285 themeOf Myr-Akt,expressed
R10026 T15256 T15286 themeOf Akt,reduction
R10027 T15257 T15287 themeOf S473D mutant,phosphorylated
R10028 T15259 T15288 themeOf S473A,phosphorylated
R10029 T15261 T15290 themeOf c-Jun,promoting
R10030 T15261 T15289 themeOf c-Jun,phosphorylation
R10031 T15263 T15291 themeOf T308D,phosphorylation
R10032 T15270 T15293 themeOf TNFα,synthesis
R10040 T15289 T15290 themeOf phosphorylation,promoting
R10041 T15293 T15292 themeOf synthesis,promote

DLUT931

Id Subject Object Predicate Lexical cue
T15160 719-728 Negative_regulation denotes reduction
T15159 140-149 Gene_expression denotes expressed
T15158 101-111 Gene_expression denotes production
T15143 2455-2459 Protein denotes TNFα
T15142 2209-2215 Protein denotes p70S6K
T15141 2199-2203 Protein denotes MDM2
T15140 2192-2197 Protein denotes Foxo4
T15139 2185-2190 Protein denotes FoxO1
T15138 2133-2140 Protein denotes Myr-Akt
T15137 2026-2031 Protein denotes T308D
T15136 1782-1787 Protein denotes T308D
T15135 1752-1756 Protein denotes TNFα
T15134 1741-1746 Protein denotes c-Jun
T15133 1576-1580 Protein denotes PDK1
T15132 1406-1411 Protein denotes S473A
T15131 1339-1344 Protein denotes S473A
T15130 1214-1226 Protein denotes S473D mutant
T15129 758-761 Protein denotes Akt
T15128 150-157 Protein denotes Myr-Akt
T15127 96-100 Protein denotes TNFα
T15167 2063-2078 Phosphorylation denotes phosphorylation
T15166 1862-1877 Phosphorylation denotes phosphorylation
T15165 1714-1729 Phosphorylation denotes phosphorylation
T15164 1692-1701 Positive_regulation denotes promoting
T15163 1584-1597 Phosphorylation denotes phosphorylate
T15162 1441-1455 Phosphorylation denotes phosphorylated
T15161 1238-1252 Phosphorylation denotes phosphorylated
T15168 2111-2125 Phosphorylation denotes phosphorylated
R9966 T15127 T15158 themeOf TNFα,production
R9967 T15128 T15159 themeOf Myr-Akt,expressed
R9968 T15129 T15160 themeOf Akt,reduction
R9969 T15130 T15161 themeOf S473D mutant,phosphorylated
R9970 T15132 T15162 themeOf S473A,phosphorylated
R9971 T15133 T15163 themeOf PDK1,phosphorylate
R9972 T15134 T15165 themeOf c-Jun,phosphorylation
R9973 T15135 T15164 themeOf TNFα,promoting
R9974 T15136 T15166 themeOf T308D,phosphorylation
R9975 T15137 T15167 themeOf T308D,phosphorylation
R9976 T15138 T15168 themeOf Myr-Akt,phosphorylated
R9977 T15139 T15168 themeOf FoxO1,phosphorylated
R9978 T15140 T15168 themeOf Foxo4,phosphorylated
R9979 T15141 T15168 themeOf MDM2,phosphorylated
R9980 T15142 T15168 themeOf p70S6K,phosphorylated
R9991 T15165 T15164 themeOf phosphorylation,promoting

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T15770 2471-2485 Positive_regulation denotes JNK activation
T15769 1714-1746 Phosphorylation denotes phosphorylation of JNK and c-Jun
T15768 1714-1746 Phosphorylation denotes phosphorylation of JNK and c-Jun
T15762 1154-1181 Positive_regulation denotes promote necroptotic changes
T15760 80-94 Positive_regulation denotes JNK activation
T15747 68-111 Gene_expression denotes cell death, JNK activation, TNFα production
T15742 1752-1761 Protein denotes TNFα mRNA
T15739 1817-1820 Protein denotes Akt
T15738 2002-2011 Entity denotes the cells
T15737 1985-1998 Entity denotes of substrates
T15736 1845-1877 Entity denotes perfect mimic of phosphorylation
T15734 839-864 Protein denotes Asp mutants at both sites
T15733 1256-1262 Entity denotes Thr308
T15732 2395-2398 Protein denotes Akt
T15701 207-210 Protein denotes Akt
T15700 1651-1657 Entity denotes Thr308
T15696 975-986 Entity denotes Ala mutants
T15695 1091-1097 Entity denotes Ser473
T15692 280-286 Protein denotes of Akt
T15691 763-780 Protein denotes while Asp mutants
T15689 1733-1736 Protein denotes JNK
T15688 312-315 Protein denotes Akt
T15687 1741-1746 Protein denotes c-Jun
T15686 300-304 Protein denotes Full
T15680 1499-1506 Entity denotes the Ala
T15679 2199-2203 Protein denotes MDM2
T15678 1557-1571 Entity denotes a docking site
T15676 676-679 Entity denotes Ala
T15673 704-710 Entity denotes Ser473
T15671 341-354 Entity denotes the PH domain
T15669 572-578 Entity denotes Thr308
T15665 1782-1831 Protein denotes T308D, in spite of being an active Akt construct,
T15664 1628-1631 Entity denotes Ala
T15662 253-289 Entity denotes that membrane localization of Akt is
T15661 2471-2474 Protein denotes JNK
T15658 2217-2220 Protein denotes Fig
T15654 831-834 Entity denotes Ala
T15652 693-699 Entity denotes Thr308
T15650 2374-2384 Protein denotes Akt kinase
T15648 150-157 Protein denotes Myr-Akt
T15646 2133-2140 Protein denotes Myr-Akt
T15645 2192-2197 Protein denotes Foxo4
T15642 429-435 Entity denotes Thr308
T15639 1333-1344 Protein denotes while S473A
T15636 1752-1756 Protein denotes TNFα
T15635 2292-2298 Entity denotes Thr308
T15629 1598-1609 Entity denotes Thr308 [39]
T15628 462-470 Entity denotes zVAD.fmk
T15626 1576-1580 Protein denotes PDK1
T15625 642-648 Protein denotes of Akt
T15623 1515-1523 Entity denotes 473 site
T15622 2026-2031 Protein denotes T308D
T15621 1080-1086 Entity denotes Thr308
T15620 80-83 Protein denotes JNK
T15618 68-100 Protein denotes cell death, JNK activation, TNFα
T15617 1406-1411 Protein denotes S473A
T15615 2416-2426 Entity denotes substrates
T15611 2185-2190 Protein denotes FoxO1
T15608 755-761 Protein denotes of Akt
T15607 2082-2215 Entity denotes several substrates that were phosphorylated by the Myr-Akt construct in the presence of zVAD including FoxO1, Foxo4, MDM2, and p70S6K
T15731 2374-2377 Protein denotes Akt
T15728 1636-1657 Protein denotes Asp mutants of Thr308
T15727 1459-1465 Entity denotes Thr308
T15726 2455-2469 Protein denotes TNFα synthesis
T15723 1899-1912 Protein denotes of the kinase
T15720 363-366 Entity denotes Myr
T15719 345-347 Protein denotes PH
T15716 1210-1227 Protein denotes the S473D mutant,
T15713 509-512 Protein denotes Fig
T15711 946-963 Protein denotes to wild type Akt,
T15709 899-915 Protein denotes both Asp mutants
T15705 2209-2215 Protein denotes p70S6K
T15703 32-48 Entity denotes zVAD.fmk-induced
R10214 T15618 T15747 themeOf "cell death, JNK activation, TNFα","cell death, JNK activation, TNFα production"
R10215 T15620 T15760 themeOf JNK,JNK activation
R10229 T15687 T15768 themeOf c-Jun,phosphorylation of JNK and c-Jun
R10225 T15661 T15770 themeOf JNK,JNK activation
R10230 T15689 T15769 themeOf JNK,phosphorylation of JNK and c-Jun

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T16656 2509-2510 . denotes .
T16655 2504-2509 NN denotes death
T16654 2499-2503 NN denotes cell
T16653 2490-2498 JJ denotes eventual
T16652 2486-2489 CC denotes and
T16651 2475-2485 NN denotes activation
T16650 2471-2474 NNP denotes JNK
T16649 2469-2470 , denotes ,
T16648 2460-2469 NN denotes synthesis
T16647 2455-2459 NNP denotes TNFα
T16646 2447-2454 VB denotes promote
T16645 2445-2446 , denotes ,
T16644 2434-2445 NN denotes necroptosis
T16643 2427-2433 IN denotes during
T16642 2416-2426 NNS denotes substrates
T16641 2402-2415 VB denotes phosphorylate
T16640 2399-2401 TO denotes to
T16639 2395-2398 NNP denotes Akt
T16583 2063-2078 NN denotes phosphorylation
T16582 2052-2062 JJ denotes downstream
T16581 2048-2051 DT denotes the
T16580 2040-2047 VB denotes support
T16579 2036-2039 RB denotes not
T16578 2032-2035 VBD denotes did
T16577 2026-2031 CD denotes T308D
T16576 2024-2025 , denotes ,
T16575 2018-2024 VBN denotes tested
T16574 2013-2017 WRB denotes When
T16573 2011-2012 . denotes .
T16572 2006-2011 NNS denotes cells
T16571 2002-2005 DT denotes the
T16570 1999-2001 IN denotes in
T16569 1988-1998 NNS denotes substrates
T16568 1985-1987 IN denotes of
T16567 1974-1984 NN denotes repertoire
T16566 1967-1973 JJ denotes entire
T16565 1963-1966 DT denotes the
T16564 1949-1962 VB denotes phosphorylate
T16563 1946-1948 TO denotes to
T16562 1937-1945 NN denotes activity
T16561 1926-1936 JJ denotes sufficient
T16560 1921-1925 VB denotes have
T16559 1917-1920 RB denotes not
T16558 1913-1916 MD denotes may
T16557 1906-1912 NN denotes kinase
T16556 1902-1905 DT denotes the
T16555 1899-1901 IN denotes of
T16554 1894-1898 NN denotes form
T16553 1887-1893 JJ denotes mutant
T16552 1882-1886 DT denotes this
T16551 1878-1881 CC denotes and
T16550 1862-1877 NN denotes phosphorylation
T16549 1859-1861 IN denotes of
T16548 1853-1858 VB denotes mimic
T16547 1845-1852 JJ denotes perfect
T16546 1843-1844 DT denotes a
T16545 1840-1842 VB denotes be
T16544 1836-1839 RB denotes not
T16543 1832-1835 MD denotes may
T16542 1830-1831 , denotes ,
T16541 1821-1830 VBP denotes construct
T16540 1817-1820 NNP denotes Akt
T16539 1810-1816 JJ denotes active
T16538 1807-1809 DT denotes an
T16537 1801-1806 VBG denotes being
T16536 1798-1800 IN denotes of
T16535 1792-1797 NN denotes spite
T16534 1789-1791 IN denotes in
T16533 1787-1788 , denotes ,
T16532 1782-1787 CD denotes T308D
T16531 1777-1781 IN denotes that
T16530 1768-1776 VBZ denotes suggests
T16529 1763-1767 DT denotes This
T16528 1761-1762 . denotes .
T16527 1757-1761 NNP denotes mRNA
T16526 1752-1756 NNP denotes TNFα
T16525 1748-1751 CC denotes and
T16524 1746-1747 , denotes ,
T16523 1741-1746 NNP denotes c-Jun
T16522 1737-1740 CC denotes and
T16521 1733-1736 NNP denotes JNK
T16520 1730-1732 IN denotes of
T16519 1714-1729 NN denotes phosphorylation
T16518 1712-1713 , denotes ,
T16517 1707-1712 NN denotes death
T16516 1702-1706 NN denotes cell
T16515 1692-1701 VBG denotes promoting
T16514 1689-1691 IN denotes in
T16513 1682-1688 JJ denotes active
T16512 1677-1681 RBR denotes less
T16511 1663-1676 RB denotes significantly
T16510 1658-1662 VBD denotes were
T16509 1651-1657 CD denotes Thr308
T16508 1648-1650 IN denotes of
T16507 1640-1647 NNS denotes mutants
T16506 1636-1639 NNP denotes Asp
T16505 1632-1635 CC denotes and
T16504 1628-1631 NNP denotes Ala
T16503 1623-1627 DT denotes both
T16502 1621-1622 , denotes ,
T16501 1611-1621 RB denotes Strikingly
T16500 1609-1610 . denotes .
T16499 1608-1609 NNP denotes ]
T16498 1606-1608 CD denotes 39
T16497 1605-1606 NNP denotes [
T16496 1598-1604 NNP denotes Thr308
T16495 1584-1597 VB denotes phosphorylate
T16494 1581-1583 TO denotes to
T16493 1576-1580 CD denotes PDK1
T16492 1572-1575 IN denotes for
T16491 1567-1571 NN denotes site
T16490 1559-1566 NN denotes docking
T16489 1557-1558 DT denotes a
T16488 1549-1556 VB denotes provide
T16487 1545-1548 CC denotes and
T16486 1530-1544 VBN denotes phosphorylated
T16485 1527-1529 VB denotes be
T16484 1524-1526 TO denotes to
T16483 1519-1523 NN denotes site
T16482 1515-1518 CD denotes 473
T16481 1507-1514 VBD denotes mutated
T16480 1503-1506 NNP denotes Ala
T16479 1499-1502 DT denotes the
T16478 1496-1498 IN denotes of
T16477 1486-1495 NN denotes inability
T16476 1482-1485 DT denotes the
T16475 1479-1481 TO denotes to
T16474 1475-1478 JJ denotes due
T16473 1466-1474 RB denotes possibly
T16472 1459-1465 CD denotes Thr308
T16471 1456-1458 IN denotes on
T16470 1441-1455 VBN denotes phosphorylated
T16469 1429-1440 RB denotes efficiently
T16468 1426-1428 VB denotes be
T16467 1423-1425 TO denotes to
T16466 1416-1422 JJ denotes unable
T16465 1412-1415 VBD denotes was
T16464 1406-1411 CD denotes S473A
T16463 1404-1405 . denotes .
T16462 1393-1404 NN denotes necroptosis
T16461 1390-1392 IN denotes of
T16460 1382-1389 NNS denotes aspects
T16459 1378-1381 DT denotes all
T16458 1375-1377 IN denotes in
T16457 1368-1374 JJ denotes active
T16456 1363-1367 RBR denotes less
T16455 1349-1362 RB denotes significantly
T16454 1345-1348 VBD denotes was
T16453 1339-1344 NNP denotes S473A
T16452 1333-1338 IN denotes while
T16451 1331-1332 , denotes ,
T16450 1323-1331 NN denotes activity
T16449 1315-1322 JJ denotes reduced
T16448 1306-1314 RB denotes slightly
T16447 1301-1305 RB denotes only
T16405 1080-1086 NNP denotes Thr308
T16404 1078-1079 , denotes ,
T16403 1068-1078 NNS denotes activities
T16402 1058-1067 JJ denotes catalytic
T16401 1050-1057 JJ denotes similar
T16400 1042-1049 IN denotes Despite
T16399 1040-1041 . denotes .
T16398 1039-1040 -RRB- denotes )
T16397 1036-1039 CD denotes S8C
T16396 1034-1035 . denotes .
T16395 1031-1034 NNP denotes Fig
T16394 1030-1031 -LRB- denotes (
T16393 1021-1029 NN denotes activity
T16392 1018-1020 IN denotes in
T16391 1008-1017 VBZ denotes decreases
T16390 997-1007 JJ denotes comparable
T16389 987-996 VBD denotes displayed
T16388 979-986 NNS denotes mutants
T16387 975-978 NNP denotes Ala
T16386 970-974 DT denotes both
T16339 729-731 IN denotes in
T16338 719-728 NN denotes reduction
T16337 717-718 DT denotes a
T16336 711-716 NN denotes cause
T16335 704-710 CD denotes Ser473
T16334 700-703 CC denotes and
T16333 693-699 CD denotes Thr308
T16332 690-692 IN denotes at
T16331 680-689 NNS denotes mutations
T16330 676-679 NNP denotes Ala
T16329 671-675 IN denotes that
T16328 662-670 VBN denotes reported
T16327 657-661 VBN denotes been
T16326 653-656 VBZ denotes has
T16325 650-652 PRP denotes It
T16324 648-649 . denotes .
T16323 645-648 NNP denotes Akt
T16322 642-644 IN denotes of
T16321 632-641 NNS denotes functions
T16320 620-631 JJ denotes necroptotic
T16319 616-619 DT denotes the
T16318 613-615 IN denotes of
T16317 602-612 NN denotes regulation
T16316 598-601 DT denotes the
T16315 595-597 IN denotes in
T16314 579-594 NN denotes phosphorylation
T16313 572-578 NNP denotes Thr308
T16312 568-571 IN denotes for
T16311 563-567 NN denotes role
T16310 554-562 JJ denotes critical
T16309 550-553 CC denotes and
T16308 541-549 JJ denotes specific
T16307 539-540 DT denotes a
T16306 533-538 VBD denotes found
T16305 530-532 PRP denotes we
T16304 528-529 , denotes ,
T16303 522-528 NNP denotes Second
T16302 520-521 . denotes .
T16301 519-520 -RRB- denotes )
T16300 518-519 NNP denotes B
T16299 517-518 , denotes ,
T16298 514-517 CD denotes S8A
T16297 512-513 . denotes .
T16296 509-512 NNP denotes Fig
T16295 508-509 -LRB- denotes (
T16294 497-507 NNS denotes conditions
T16293 492-496 JJ denotes free
T16292 486-491 NN denotes serum
T16291 480-485 IN denotes under
T16290 471-479 NN denotes addition
T16289 462-470 NNP denotes zVAD.fmk
T16288 452-461 VBG denotes following
T16287 436-451 NN denotes phosphorylation
T16286 429-435 JJ denotes Thr308
T16285 419-428 VBN denotes increased
T16284 416-418 CC denotes or
T16283 410-415 NN denotes death
T16282 405-409 NN denotes cell
T16281 402-404 IN denotes of
T16280 391-401 NN denotes activation
T16279 387-390 DT denotes the
T16278 379-386 VB denotes support
T16277 375-378 RB denotes not
T16276 371-374 VBD denotes did
T16275 367-370 NN denotes tag
T16274 363-366 NNP denotes Myr
T16273 359-362 DT denotes the
T16272 355-358 CC denotes and
T16271 348-354 NN denotes domain
T16270 345-347 NNP denotes PH
T16269 341-344 DT denotes the
T16268 336-340 DT denotes both
T16267 328-335 VBG denotes lacking
T16266 321-327 JJ denotes mutant
T16265 319-320 DT denotes a
T16264 316-318 CC denotes or
T16263 312-315 NNP denotes Akt
T16262 305-311 NN denotes length
T16261 300-304 JJ denotes Full
T16260 298-299 . denotes .
T16259 290-298 VBN denotes required
T16258 287-289 VBZ denotes is
T16257 283-286 NNP denotes Akt
T16256 280-282 IN denotes of
T16255 267-279 NN denotes localization
T16254 258-266 NN denotes membrane
T16253 253-257 IN denotes that
T16252 247-252 VBD denotes found
T16251 244-246 PRP denotes we
T16250 242-243 , denotes ,
T16249 237-242 RB denotes First
T16248 235-236 . denotes .
T16247 224-235 NN denotes necroptosis
T16246 221-223 IN denotes on
T16245 211-220 NNS denotes mutations
T16244 207-210 NNP denotes Akt
T16243 201-206 JJ denotes other
T16242 198-200 IN denotes of
T16241 190-197 NNS denotes effects
T16240 186-189 DT denotes the
T16239 178-185 VB denotes examine
T16238 175-177 TO denotes to
T16237 172-174 PRP denotes us
T16236 164-171 VBD denotes allowed
T16235 159-163 DT denotes This
T16234 157-158 . denotes .
T16233 150-157 NNP denotes Myr-Akt
T16232 140-149 VBN denotes expressed
T16231 135-139 JJ denotes over
T16230 131-134 DT denotes the
T16229 128-130 IN denotes on
T16228 118-127 JJ denotes dependent
T16227 113-117 VBD denotes were
T16226 111-112 -RRB- denotes )
T16225 101-111 NN denotes production
T16224 96-100 JJ denotes TNFα
T16223 94-95 , denotes ,
T16222 84-94 NN denotes activation
T16221 80-83 NNP denotes JNK
T16220 78-79 , denotes ,
T16219 73-78 NN denotes death
T16218 68-72 NN denotes cell
T16217 67-68 -LRB- denotes (
T16216 60-66 NNS denotes events
T16215 49-59 JJ denotes downstream
T16214 32-48 JJ denotes zVAD.fmk-induced
T16213 28-31 DT denotes all
T16212 17-27 NNS denotes conditions
T16211 12-16 JJ denotes free
T16210 6-11 NN denotes serum
T16209 0-5 IN denotes Under
T16638 2386-2394 VBG denotes allowing
T16637 2384-2385 , denotes ,
T16636 2378-2384 NN denotes kinase
T16635 2374-2377 NNP denotes Akt
T16634 2370-2373 CC denotes and
T16633 2360-2369 NN denotes machinery
T16632 2348-2359 JJ denotes necroptotic
T16631 2340-2347 IN denotes between
T16630 2335-2339 NN denotes link
T16629 2326-2334 JJ denotes critical
T16628 2324-2325 DT denotes a
T16627 2315-2323 VBZ denotes provides
T16626 2299-2314 NN denotes phosphorylation
T16625 2292-2298 NNP denotes Thr308
T16624 2271-2291 JJ denotes necroptosis-specific
T16623 2266-2270 IN denotes that
T16622 2263-2265 VBZ denotes is
T16621 2261-2262 , denotes ,
T16620 2254-2261 NNS denotes results
T16619 2248-2253 DT denotes these
T16618 2245-2247 IN denotes on
T16617 2239-2244 VBN denotes based
T16616 2237-2238 , denotes ,
T16615 2232-2237 NN denotes model
T16614 2228-2231 PRP$ denotes Our
T16613 2226-2227 . denotes .
T16612 2225-2226 -RRB- denotes )
T16611 2222-2225 CD denotes S8D
T16610 2220-2221 . denotes .
T16609 2217-2220 NNP denotes Fig
T16608 2216-2217 -LRB- denotes (
T16607 2209-2215 NNP denotes p70S6K
T16606 2205-2208 CC denotes and
T16605 2203-2204 , denotes ,
T16604 2199-2203 NNP denotes MDM2
T16603 2197-2198 , denotes ,
T16602 2192-2197 NNP denotes Foxo4
T16601 2190-2191 , denotes ,
T16600 2185-2190 NNP denotes FoxO1
T16599 2175-2184 VBG denotes including
T16598 2170-2174 NNP denotes zVAD
T16597 2167-2169 IN denotes of
T16596 2158-2166 NN denotes presence
T16595 2154-2157 DT denotes the
T16594 2151-2153 IN denotes in
T16593 2141-2150 VBP denotes construct
T16592 2133-2140 NNP denotes Myr-Akt
T16591 2129-2132 DT denotes the
T16590 2126-2128 IN denotes by
T16589 2111-2125 VBN denotes phosphorylated
T16588 2106-2110 VBD denotes were
T16587 2101-2105 WDT denotes that
T16586 2090-2100 NNS denotes substrates
T16585 2082-2089 JJ denotes several
T16584 2079-2081 IN denotes of
T16349 781-789 NN denotes increase
T16348 773-780 NNS denotes mutants
T16347 769-772 NNP denotes Asp
T16346 763-768 IN denotes while
T16345 761-762 , denotes ,
T16344 758-761 NNP denotes Akt
T16343 755-757 IN denotes of
T16342 746-754 NN denotes activity
T16341 736-745 JJ denotes catalytic
T16340 732-735 DT denotes the
T16385 964-969 IN denotes while
T16384 962-963 , denotes ,
T16383 959-962 NNP denotes Akt
T16382 954-958 NN denotes type
T16381 949-953 JJ denotes wild
T16380 946-948 TO denotes to
T16379 935-945 JJ denotes comparable
T16378 926-934 NN denotes activity
T16377 916-925 VBD denotes displayed
T16376 908-915 NNS denotes mutants
T16375 904-907 NNP denotes Asp
T16374 899-903 DT denotes both
T16373 897-898 , denotes ,
T16372 892-897 NNS denotes hands
T16371 888-891 PRP$ denotes our
T16370 885-887 IN denotes In
T16369 883-884 . denotes .
T16368 872-883 NN denotes necroptosis
T16367 865-871 IN denotes during
T16366 859-864 NNS denotes sites
T16365 854-858 DT denotes both
T16364 851-853 IN denotes at
T16363 843-850 NNS denotes mutants
T16362 839-842 NNP denotes Asp
T16361 835-838 CC denotes and
T16360 831-834 NNP denotes Ala
T16359 828-830 IN denotes of
T16358 821-827 NN denotes effect
T16357 817-820 DT denotes the
T16356 808-816 VBD denotes examined
T16355 805-807 PRP denotes We
T16354 803-804 . denotes .
T16353 802-803 NNP denotes ]
T16352 800-802 CD denotes 38
T16351 799-800 NNP denotes [
T16350 790-798 NN denotes activity
T16446 1291-1300 VBD denotes displayed
T16445 1289-1290 , denotes ,
T16444 1285-1289 NNP denotes zVAD
T16443 1282-1284 IN denotes of
T16442 1273-1281 NN denotes addition
T16441 1269-1272 DT denotes the
T16440 1263-1268 IN denotes after
T16439 1256-1262 CD denotes Thr308
T16438 1253-1255 IN denotes on
T16437 1238-1252 VBN denotes phosphorylated
T16436 1234-1237 VBD denotes was
T16435 1228-1233 WDT denotes which
T16434 1226-1227 , denotes ,
T16433 1220-1226 JJ denotes mutant
T16432 1214-1219 NNP denotes S473D
T16431 1210-1213 DT denotes the
T16430 1208-1209 , denotes ,
T16429 1200-1208 VBN denotes expected
T16428 1197-1199 IN denotes As
T16427 1195-1196 . denotes .
T16426 1194-1195 -RRB- denotes )
T16425 1193-1194 NNP denotes G
T16424 1192-1193 , denotes ,
T16423 1191-1192 NN denotes F
T16422 1190-1191 , denotes ,
T16421 1188-1190 NNP denotes 7E
T16420 1183-1187 NNP denotes Fig.
T16419 1182-1183 -LRB- denotes (
T16418 1174-1181 NNS denotes changes
T16417 1162-1173 JJ denotes necroptotic
T16416 1154-1161 VB denotes promote
T16415 1151-1153 TO denotes to
T16414 1143-1150 NN denotes ability
T16413 1137-1142 PRP$ denotes their
T16412 1134-1136 IN denotes in
T16411 1122-1133 NNS denotes differences
T16410 1116-1121 JJ denotes major
T16409 1106-1115 VBD denotes displayed
T16408 1098-1105 NNS denotes mutants
T16407 1091-1097 NNP denotes Ser473
T16406 1087-1090 CC denotes and
R10665 T16253 T16259 mark that,required
R10667 T16254 T16255 compound membrane,localization
R10669 T16255 T16259 nsubjpass localization,required
R10670 T16256 T16255 prep of,localization
R10672 T16257 T16256 pobj Akt,of
R10673 T16258 T16259 auxpass is,required
R10675 T16259 T16252 ccomp required,found
R10678 T16260 T16252 punct .,found
R10679 T16261 T16262 amod Full,length
R10680 T16262 T16263 compound length,Akt
R10682 T16263 T16278 nsubj Akt,support
R10683 T16264 T16263 cc or,Akt
R10684 T16265 T16266 det a,mutant
R10686 T16266 T16263 conj mutant,Akt
R10687 T16267 T16263 acl lacking,Akt
R10688 T16268 T16271 preconj both,domain
R10690 T16269 T16271 det the,domain
R10691 T16270 T16271 compound PH,domain
R10693 T16271 T16267 dobj domain,lacking
R10694 T16272 T16271 cc and,domain
R10696 T16273 T16275 det the,tag
R10697 T16274 T16275 compound Myr,tag
R10698 T16275 T16271 conj tag,domain
R10700 T16276 T16278 aux did,support
R10701 T16277 T16278 neg not,support
R10702 T16278 T16278 ROOT support,support
R10704 T16279 T16280 det the,activation
R10705 T16280 T16278 dobj activation,support
R10706 T16281 T16280 prep of,activation
R10708 T16282 T16283 compound cell,death
R10709 T16283 T16281 pobj death,of
R10710 T16284 T16280 cc or,activation
R10711 T16285 T16287 amod increased,phosphorylation
R10712 T16286 T16287 amod Thr308,phosphorylation
R10713 T16287 T16280 conj phosphorylation,activation
R10715 T16288 T16278 prep following,support
R10716 T16289 T16290 compound zVAD.fmk,addition
R10717 T16290 T16288 pobj addition,following
R10719 T16291 T16290 prep under,addition
R10720 T16292 T16293 npadvmod serum,free
R10721 T16293 T16294 amod free,conditions
R10722 T16209 T16232 prep Under,expressed
R10723 T16294 T16291 pobj conditions,under
R10724 T16295 T16278 punct (,support
R10725 T16296 T16278 dobj Fig,support
R10726 T16297 T16296 punct .,Fig
R10727 T16210 T16212 nmod serum,conditions
R10728 T16298 T16298 ROOT S8A,S8A
R10729 T16299 T16300 punct ",",B
R10730 T16211 T16212 amod free,conditions
R10731 T16300 T16298 appos B,S8A
R10732 T16301 T16298 punct ),S8A
R10733 T16302 T16298 punct .,S8A
R10734 T16303 T16306 advmod Second,found
R10735 T16212 T16209 pobj conditions,Under
R10736 T16304 T16306 punct ",",found
R10737 T16305 T16306 nsubj we,found
R10738 T16213 T16216 det all,events
R10739 T16306 T16306 ROOT found,found
R10740 T16214 T16216 amod zVAD.fmk-induced,events
R10741 T16215 T16216 amod downstream,events
R10742 T16307 T16311 det a,role
R10743 T16308 T16311 amod specific,role
R10744 T16216 T16232 nsubj events,expressed
R10745 T16309 T16308 cc and,specific
R10746 T16310 T16308 conj critical,specific
R10747 T16217 T16219 punct (,death
R10748 T16311 T16306 dobj role,found
R10749 T16312 T16311 prep for,role
R10750 T16218 T16219 compound cell,death
R10751 T16313 T16314 compound Thr308,phosphorylation
R10752 T16314 T16312 pobj phosphorylation,for
R10753 T16315 T16314 prep in,phosphorylation
R10754 T16219 T16216 dobj death,events
R10755 T16316 T16317 det the,regulation
R10756 T16317 T16315 pobj regulation,in
R10757 T16318 T16317 prep of,regulation
R10758 T16319 T16321 det the,functions
R10759 T16320 T16321 amod necroptotic,functions
R10760 T16220 T16216 punct ",",events
R10761 T16321 T16318 pobj functions,of
R10762 T16322 T16321 prep of,functions
R10763 T16323 T16322 pobj Akt,of
R10764 T16221 T16222 compound JNK,activation
R10765 T16324 T16306 punct .,found
R10766 T16325 T16328 nsubjpass It,reported
R10767 T16326 T16328 aux has,reported
R10768 T16222 T16225 nmod activation,production
R10769 T16327 T16328 auxpass been,reported
R10770 T16328 T16328 ROOT reported,reported
R10771 T16329 T16336 mark that,cause
R10772 T16223 T16225 punct ",",production
R10773 T16330 T16331 compound Ala,mutations
R10774 T16331 T16336 nsubj mutations,cause
R10775 T16332 T16331 prep at,mutations
R10776 T16224 T16225 compound TNFα,production
R10777 T16333 T16332 pobj Thr308,at
R10778 T16334 T16333 cc and,Thr308
R10779 T16335 T16333 conj Ser473,Thr308
R10780 T16225 T16228 nsubjpass production,dependent
R10781 T16336 T16328 ccomp cause,reported
R10782 T16337 T16338 det a,reduction
R10783 T16338 T16336 dobj reduction,cause
R10784 T16226 T16225 punct ),production
R10785 T16227 T16228 auxpass were,dependent
R10786 T16339 T16338 prep in,reduction
R10787 T16228 T16216 advcl dependent,events
R10788 T16340 T16342 det the,activity
R10789 T16229 T16228 prep on,dependent
R10790 T16341 T16342 amod catalytic,activity
R10791 T16230 T16231 det the,over
R10792 T16231 T16229 pobj over,on
R10793 T16342 T16339 pobj activity,in
R10794 T16232 T16232 ROOT expressed,expressed
R10795 T16343 T16342 prep of,activity
R10796 T16233 T16232 dobj Myr-Akt,expressed
R10797 T16234 T16232 punct .,expressed
R10798 T16344 T16343 pobj Akt,of
R10799 T16235 T16236 nsubj This,allowed
R10800 T16345 T16336 punct ",",cause
R10801 T16236 T16236 ROOT allowed,allowed
R10802 T16346 T16349 mark while,increase
R10803 T16347 T16348 amod Asp,mutants
R10804 T16237 T16239 nsubj us,examine
R10805 T16348 T16349 nsubj mutants,increase
R10806 T16349 T16336 advcl increase,cause
R10807 T16238 T16239 aux to,examine
R10808 T16239 T16236 ccomp examine,allowed
R10809 T16350 T16349 dobj activity,increase
R10810 T16240 T16241 det the,effects
R10811 T16351 T16353 nmod [,]
R10812 T16352 T16353 nummod 38,]
R10813 T16241 T16239 dobj effects,examine
R10814 T16353 T16350 appos ],activity
R10815 T16354 T16328 punct .,reported
R10816 T16242 T16241 prep of,effects
R10817 T16355 T16356 nsubj We,examined
R10818 T16356 T16356 ROOT examined,examined
R10819 T16243 T16245 amod other,mutations
R10820 T16357 T16358 det the,effect
R10821 T16358 T16356 dobj effect,examined
R10822 T16244 T16245 compound Akt,mutations
R10823 T16359 T16358 prep of,effect
R10824 T16360 T16359 pobj Ala,of
R10825 T16361 T16360 cc and,Ala
R10826 T16245 T16242 pobj mutations,of
R10827 T16362 T16360 conj Asp,Ala
R10828 T16363 T16359 pobj mutants,of
R10829 T16364 T16363 prep at,mutants
R10830 T16246 T16245 prep on,mutations
R10831 T16365 T16366 det both,sites
R10832 T16366 T16364 pobj sites,at
R10833 T16247 T16246 pobj necroptosis,on
R10834 T16367 T16356 prep during,examined
R10835 T16368 T16367 pobj necroptosis,during
R10836 T16369 T16356 punct .,examined
R10837 T16370 T16377 prep In,displayed
R10838 T16248 T16236 punct .,allowed
R10839 T16371 T16372 poss our,hands
R10840 T16372 T16370 pobj hands,In
R10841 T16249 T16252 advmod First,found
R10842 T16373 T16377 punct ",",displayed
R10843 T16374 T16376 det both,mutants
R10844 T16375 T16376 compound Asp,mutants
R10845 T16250 T16252 punct ",",found
R10846 T16376 T16377 nsubj mutants,displayed
R10847 T16377 T16377 ROOT displayed,displayed
R10848 T16378 T16377 dobj activity,displayed
R10849 T16251 T16252 nsubj we,found
R10850 T16379 T16378 amod comparable,activity
R10851 T16380 T16383 prep to,Akt
R10852 T16252 T16252 ROOT found,found
R10853 T16381 T16382 amod wild,type
R10854 T16382 T16380 pobj type,to
R10855 T16383 T16377 oprd Akt,displayed
R10856 T16406 T16405 cc and,Thr308
R10857 T16384 T16377 punct ",",displayed
R10858 T16385 T16389 mark while,displayed
R10859 T16386 T16388 det both,mutants
R10860 T16387 T16388 compound Ala,mutants
R10861 T16407 T16405 conj Ser473,Thr308
R10862 T16388 T16389 nsubj mutants,displayed
R10863 T16389 T16377 advcl displayed,displayed
R10864 T16390 T16391 amod comparable,decreases
R10865 T16391 T16389 dobj decreases,displayed
R10866 T16408 T16409 nsubj mutants,displayed
R10867 T16392 T16389 prep in,displayed
R10868 T16393 T16392 pobj activity,in
R10869 T16409 T16409 ROOT displayed,displayed
R10870 T16394 T16395 punct (,Fig
R10871 T16395 T16393 appos Fig,activity
R10872 T16396 T16377 punct .,displayed
R10873 T16397 T16397 ROOT S8C,S8C
R10874 T16410 T16411 amod major,differences
R10875 T16398 T16397 punct ),S8C
R10876 T16399 T16397 punct .,S8C
R10877 T16411 T16409 dobj differences,displayed
R10878 T16400 T16409 prep Despite,displayed
R10879 T16401 T16403 amod similar,activities
R10880 T16402 T16403 amod catalytic,activities
R10881 T16412 T16411 prep in,differences
R10882 T16403 T16400 pobj activities,Despite
R10883 T16404 T16409 punct ",",displayed
R10884 T16413 T16414 poss their,ability
R10885 T16405 T16408 nmod Thr308,mutants
R10886 T16414 T16412 pobj ability,in
R10887 T16415 T16416 aux to,promote
R10888 T16416 T16414 acl promote,ability
R10889 T16417 T16418 amod necroptotic,changes
R10890 T16447 T16448 advmod only,slightly
R10891 T16418 T16416 dobj changes,promote
R10892 T16448 T16449 advmod slightly,reduced
R10893 T16449 T16450 amod reduced,activity
R10894 T16419 T16421 punct (,7E
R10895 T16450 T16446 dobj activity,displayed
R10896 T16451 T16446 punct ",",displayed
R10897 T16452 T16454 mark while,was
R10898 T16420 T16421 compound Fig.,7E
R10899 T16453 T16454 nsubj S473A,was
R10900 T16454 T16446 advcl was,displayed
R10901 T16421 T16425 dep 7E,G
R10902 T16455 T16457 advmod significantly,active
R10903 T16456 T16457 advmod less,active
R10904 T16457 T16454 acomp active,was
R10905 T16458 T16457 prep in,active
R10906 T16422 T16421 punct ",",7E
R10907 T16459 T16460 det all,aspects
R10908 T16460 T16458 pobj aspects,in
R10909 T16461 T16460 prep of,aspects
R10910 T16462 T16461 pobj necroptosis,of
R10911 T16463 T16437 punct .,phosphorylated
R10912 T16423 T16425 advmod F,G
R10913 T16464 T16465 nsubj S473A,was
R10914 T16465 T16465 ROOT was,was
R10915 T16466 T16465 acomp unable,was
R10916 T16424 T16425 punct ",",G
R10917 T16467 T16470 aux to,phosphorylated
R10918 T16468 T16470 auxpass be,phosphorylated
R10919 T16469 T16470 advmod efficiently,phosphorylated
R10920 T16425 T16416 dep G,promote
R10921 T16470 T16466 xcomp phosphorylated,unable
R10922 T16471 T16470 prep on,phosphorylated
R10923 T16472 T16481 punct Thr308,mutated
R10924 T16426 T16409 punct ),displayed
R10925 T16473 T16474 advmod possibly,due
R10926 T16427 T16409 punct .,displayed
R10927 T16474 T16481 prep due,mutated
R10928 T16475 T16474 pcomp to,due
R10929 T16428 T16429 mark As,expected
R10930 T16476 T16477 det the,inability
R10931 T16477 T16481 nsubj inability,mutated
R10932 T16478 T16477 prep of,inability
R10933 T16429 T16437 advcl expected,phosphorylated
R10934 T16479 T16480 det the,Ala
R10935 T16480 T16478 pobj Ala,of
R10936 T16481 T16481 ROOT mutated,mutated
R10937 T16482 T16483 nummod 473,site
R10938 T16430 T16437 punct ",",phosphorylated
R10939 T16483 T16481 dobj site,mutated
R10940 T16484 T16486 aux to,phosphorylated
R10941 T16431 T16433 det the,mutant
R10942 T16485 T16486 auxpass be,phosphorylated
R10943 T16486 T16483 relcl phosphorylated,site
R10944 T16487 T16481 cc and,mutated
R10945 T16488 T16481 conj provide,mutated
R10946 T16432 T16433 compound S473D,mutant
R10947 T16489 T16491 det a,site
R10948 T16490 T16491 compound docking,site
R10949 T16433 T16437 nsubjpass mutant,phosphorylated
R10950 T16491 T16488 dobj site,provide
R10951 T16492 T16495 mark for,phosphorylate
R10952 T16493 T16495 nsubj PDK1,phosphorylate
R10953 T16434 T16433 punct ",",mutant
R10954 T16494 T16495 aux to,phosphorylate
R10955 T16495 T16491 advcl phosphorylate,site
R10956 T16496 T16497 compound Thr308,[
R10957 T16435 T16436 nsubj which,was
R10958 T16497 T16495 dobj [,phosphorylate
R10959 T16498 T16499 nummod 39,]
R10960 T16499 T16497 appos ],[
R10961 T16500 T16481 punct .,mutated
R10962 T16501 T16510 advmod Strikingly,were
R10963 T16436 T16437 auxpass was,phosphorylated
R10964 T16502 T16510 punct ",",were
R10965 T16437 T16437 ROOT phosphorylated,phosphorylated
R10966 T16503 T16504 det both,Ala
R10967 T16504 T16510 nsubj Ala,were
R10968 T16505 T16504 cc and,Ala
R10969 T16438 T16437 prep on,phosphorylated
R10970 T16506 T16504 conj Asp,Ala
R10971 T16507 T16504 conj mutants,Ala
R10972 T16508 T16507 prep of,mutants
R10973 T16439 T16438 pobj Thr308,on
R10974 T16509 T16508 pobj Thr308,of
R10975 T16510 T16510 ROOT were,were
R10976 T16440 T16437 prep after,phosphorylated
R10977 T16511 T16513 advmod significantly,active
R10978 T16512 T16513 advmod less,active
R10979 T16513 T16510 acomp active,were
R10980 T16441 T16442 det the,addition
R10981 T16514 T16513 prep in,active
R10982 T16442 T16440 pobj addition,after
R10983 T16515 T16514 pcomp promoting,in
R10984 T16516 T16517 compound cell,death
R10985 T16517 T16515 dobj death,promoting
R10986 T16518 T16514 punct ",",in
R10987 T16443 T16442 prep of,addition
R10988 T16519 T16513 conj phosphorylation,active
R10989 T16520 T16519 prep of,phosphorylation
R10990 T16521 T16520 pobj JNK,of
R10991 T16444 T16443 pobj zVAD,of
R10992 T16522 T16521 cc and,JNK
R10993 T16523 T16521 conj c-Jun,JNK
R10994 T16445 T16446 punct ",",displayed
R10995 T16524 T16523 punct ",",c-Jun
R10996 T16525 T16523 cc and,c-Jun
R10997 T16526 T16527 compound TNFα,mRNA
R10998 T16446 T16437 dep displayed,phosphorylated
R10999 T16527 T16523 conj mRNA,c-Jun
R11000 T16528 T16510 punct .,were
R11001 T16544 T16545 neg not,be
R11002 T16529 T16530 nsubj This,suggests
R11003 T16530 T16530 ROOT suggests,suggests
R11004 T16531 T16545 mark that,be
R11005 T16545 T16530 ccomp be,suggests
R11006 T16532 T16541 nsubj T308D,construct
R11007 T16533 T16532 punct ",",T308D
R11008 T16534 T16541 prep in,construct
R11009 T16535 T16534 pobj spite,in
R11010 T16536 T16535 prep of,spite
R11011 T16537 T16536 pcomp being,of
R11012 T16546 T16548 det a,mimic
R11013 T16538 T16540 det an,Akt
R11014 T16539 T16540 amod active,Akt
R11015 T16540 T16537 attr Akt,being
R11016 T16541 T16545 csubj construct,be
R11017 T16547 T16548 amod perfect,mimic
R11018 T16542 T16545 punct ",",be
R11019 T16543 T16545 aux may,be
R11020 T16548 T16545 attr mimic,be
R11021 T16549 T16548 prep of,mimic
R11022 T16550 T16549 pobj phosphorylation,of
R11023 T16641 T16638 ccomp phosphorylate,allowing
R11024 T16551 T16548 cc and,mimic
R11025 T16642 T16641 dobj substrates,phosphorylate
R11026 T16643 T16641 prep during,phosphorylate
R11027 T16644 T16643 pobj necroptosis,during
R11028 T16552 T16554 det this,form
R11029 T16645 T16641 punct ",",phosphorylate
R11030 T16646 T16641 dep promote,phosphorylate
R11031 T16553 T16554 amod mutant,form
R11032 T16647 T16648 compound TNFα,synthesis
R11033 T16648 T16646 dobj synthesis,promote
R11034 T16649 T16641 punct ",",phosphorylate
R11035 T16554 T16545 attr form,be
R11036 T16650 T16651 compound JNK,activation
R11037 T16651 T16641 conj activation,phosphorylate
R11038 T16555 T16554 prep of,form
R11039 T16652 T16651 cc and,activation
R11040 T16653 T16655 amod eventual,death
R11041 T16654 T16655 compound cell,death
R11042 T16556 T16557 det the,kinase
R11043 T16655 T16651 conj death,activation
R11044 T16656 T16622 punct .,is
R11045 T16557 T16555 pobj kinase,of
R11046 T16558 T16560 aux may,have
R11047 T16559 T16560 neg not,have
R11048 T16560 T16545 conj have,be
R11049 T16561 T16562 amod sufficient,activity
R11050 T16562 T16560 dobj activity,have
R11051 T16563 T16564 aux to,phosphorylate
R11052 T16564 T16562 relcl phosphorylate,activity
R11053 T16565 T16567 det the,repertoire
R11054 T16566 T16567 amod entire,repertoire
R11055 T16567 T16564 dobj repertoire,phosphorylate
R11056 T16568 T16567 prep of,repertoire
R11057 T16569 T16568 pobj substrates,of
R11058 T16570 T16569 prep in,substrates
R11059 T16571 T16572 det the,cells
R11060 T16572 T16570 pobj cells,in
R11061 T16573 T16530 punct .,suggests
R11062 T16574 T16575 advmod When,tested
R11063 T16575 T16580 advcl tested,support
R11064 T16576 T16580 punct ",",support
R11065 T16577 T16580 nsubj T308D,support
R11066 T16578 T16580 aux did,support
R11067 T16579 T16580 neg not,support
R11068 T16580 T16580 ROOT support,support
R11069 T16581 T16583 det the,phosphorylation
R11070 T16582 T16583 amod downstream,phosphorylation
R11071 T16583 T16580 dobj phosphorylation,support
R11072 T16584 T16583 prep of,phosphorylation
R11073 T16585 T16586 amod several,substrates
R11074 T16586 T16584 pobj substrates,of
R11075 T16587 T16589 nsubjpass that,phosphorylated
R11076 T16588 T16589 auxpass were,phosphorylated
R11077 T16589 T16586 relcl phosphorylated,substrates
R11078 T16590 T16589 agent by,phosphorylated
R11079 T16591 T16592 det the,Myr-Akt
R11080 T16592 T16590 pobj Myr-Akt,by
R11081 T16593 T16580 conj construct,support
R11082 T16594 T16593 prep in,construct
R11083 T16595 T16596 det the,presence
R11084 T16596 T16594 pobj presence,in
R11085 T16597 T16596 prep of,presence
R11086 T16598 T16597 pobj zVAD,of
R11087 T16599 T16596 prep including,presence
R11088 T16600 T16599 pobj FoxO1,including
R11089 T16601 T16600 punct ",",FoxO1
R11090 T16602 T16600 conj Foxo4,FoxO1
R11091 T16603 T16602 punct ",",Foxo4
R11092 T16604 T16602 conj MDM2,Foxo4
R11093 T16605 T16604 punct ",",MDM2
R11094 T16606 T16604 cc and,MDM2
R11095 T16607 T16604 conj p70S6K,MDM2
R11096 T16608 T16609 punct (,Fig
R11097 T16609 T16607 appos Fig,p70S6K
R11098 T16610 T16580 punct .,support
R11099 T16611 T16611 ROOT S8D,S8D
R11100 T16612 T16611 punct ),S8D
R11101 T16613 T16611 punct .,S8D
R11102 T16614 T16615 poss Our,model
R11103 T16615 T16622 nsubj model,is
R11104 T16616 T16615 punct ",",model
R11105 T16617 T16615 prep based,model
R11106 T16618 T16617 prep on,based
R11107 T16619 T16620 det these,results
R11108 T16620 T16618 pobj results,on
R11109 T16621 T16615 punct ",",model
R11110 T16622 T16622 ROOT is,is
R11111 T16623 T16627 mark that,provides
R11112 T16624 T16626 amod necroptosis-specific,phosphorylation
R11113 T16625 T16626 compound Thr308,phosphorylation
R11114 T16626 T16627 nsubj phosphorylation,provides
R11115 T16627 T16622 ccomp provides,is
R11116 T16628 T16630 det a,link
R11117 T16629 T16630 amod critical,link
R11118 T16630 T16627 dobj link,provides
R11119 T16631 T16630 prep between,link
R11120 T16632 T16633 amod necroptotic,machinery
R11121 T16633 T16631 pobj machinery,between
R11122 T16634 T16633 cc and,machinery
R11123 T16635 T16636 compound Akt,kinase
R11124 T16636 T16633 conj kinase,machinery
R11125 T16637 T16627 punct ",",provides
R11126 T16638 T16627 advcl allowing,provides
R11127 T16639 T16641 nsubj Akt,phosphorylate
R11128 T16640 T16641 aux to,phosphorylate

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T15449 2475-2485 Positive_regulation denotes activation
T15448 2475-2485 Positive_regulation denotes activation
T15447 2460-2469 Gene_expression denotes synthesis
T15446 2471-2474 Protein denotes JNK
T15445 2455-2459 Protein denotes TNFα
T15444 2395-2398 Protein denotes Akt
T15443 2374-2384 Protein denotes Akt kinase
T15442 2111-2125 Phosphorylation denotes phosphorylated
T15441 2111-2125 Phosphorylation denotes phosphorylated
T15440 2111-2125 Phosphorylation denotes phosphorylated
T15439 2111-2125 Phosphorylation denotes phosphorylated
T15438 2222-2225 Protein denotes S8D
T15437 2217-2220 Protein denotes Fig
T15436 2209-2215 Protein denotes p70S6K
T15435 2199-2203 Protein denotes MDM2
T15434 2192-2197 Protein denotes Foxo4
T15433 2170-2190 Protein denotes zVAD including FoxO1
T15432 2137-2140 Protein denotes Akt
T15431 2133-2136 Protein denotes Myr
T15430 1862-1877 Phosphorylation denotes phosphorylation
T15429 1817-1820 Protein denotes Akt
T15428 1692-1701 Positive_regulation denotes promoting
T15427 1692-1701 Positive_regulation denotes promoting
T15426 1714-1729 Phosphorylation denotes phosphorylation
T15425 1714-1729 Phosphorylation denotes phosphorylation
T15424 1692-1701 Positive_regulation denotes promoting
T15423 1752-1761 Protein denotes TNFα mRNA
T15422 1741-1746 Protein denotes c-Jun
T15421 1733-1736 Protein denotes JNK
T15420 1530-1544 Phosphorylation denotes phosphorylated
T15419 1441-1455 Phosphorylation denotes phosphorylated
T15418 1576-1580 Protein denotes PDK1
T15417 1459-1465 Protein denotes Thr308
T15416 1091-1105 Protein denotes Ser473 mutants
T15415 1080-1086 Protein denotes Thr308
T15414 1008-1017 Negative_regulation denotes decreases
T15413 975-986 Protein denotes Ala mutants
T15412 904-915 Protein denotes Asp mutants
T15411 821-827 Regulation denotes effect
T15410 839-850 Protein denotes Asp mutants
T15409 719-728 Negative_regulation denotes reduction
T15408 769-780 Protein denotes Asp mutants
T15407 758-761 Protein denotes Akt
T15406 563-567 Regulation denotes role
T15405 602-612 Regulation denotes regulation
T15404 579-594 Phosphorylation denotes phosphorylation
T15403 645-648 Protein denotes Akt
T15402 572-578 Protein denotes Thr308
T15401 419-428 Positive_regulation denotes increased
T15400 436-451 Phosphorylation denotes phosphorylation
T15399 328-335 Negative_regulation denotes lacking
T15398 328-335 Negative_regulation denotes lacking
T15397 429-435 Protein denotes Thr308
T15396 363-370 Protein denotes Myr tag
T15395 345-354 Protein denotes PH domain
T15394 300-315 Protein denotes Full length Akt
T15393 267-279 Localization denotes localization
T15392 283-286 Protein denotes Akt
T15391 84-94 Positive_regulation denotes activation
T15390 140-149 Gene_expression denotes expressed
T15389 140-149 Gene_expression denotes expressed
T15388 101-111 Gene_expression denotes production
T15387 84-94 Positive_regulation denotes activation
T15386 154-157 Protein denotes Akt
T15385 150-153 Protein denotes Myr
T15384 96-100 Protein denotes TNFα
T15383 80-83 Protein denotes JNK
R10094 T15383 T15387 themeOf JNK,activation
R10095 T15384 T15388 themeOf TNFα,production
R10096 T15385 T15389 themeOf Myr,expressed
R10097 T15386 T15390 themeOf Akt,expressed
R10098 T15388 T15391 themeOf production,activation
R10099 T15392 T15393 themeOf Akt,localization
R10100 T15394 T15401 causeOf Full length Akt,increased
R10101 T15395 T15398 themeOf PH domain,lacking
R10102 T15396 T15399 themeOf Myr tag,lacking
R10103 T15397 T15400 themeOf Thr308,phosphorylation
R10104 T15400 T15401 themeOf phosphorylation,increased
R10105 T15402 T15404 themeOf Thr308,phosphorylation
R10106 T15403 T15405 themeOf Akt,regulation
R10107 T15405 T15406 themeOf regulation,role
R10108 T15407 T15409 themeOf Akt,reduction
R10109 T15410 T15411 themeOf Asp mutants,effect
R10110 T15413 T15414 themeOf Ala mutants,decreases
R10111 T15417 T15419 themeOf Thr308,phosphorylated
R10112 T15417 T15420 themeOf Thr308,phosphorylated
R10113 T15421 T15425 themeOf JNK,phosphorylation
R10114 T15422 T15426 themeOf c-Jun,phosphorylation
R10115 T15423 T15424 themeOf TNFα mRNA,promoting
R10116 T15425 T15427 themeOf phosphorylation,promoting
R10117 T15426 T15428 themeOf phosphorylation,promoting
R10118 T15429 T15430 themeOf Akt,phosphorylation
R10119 T15432 T15439 themeOf Akt,phosphorylated
R10120 T15433 T15440 themeOf zVAD including FoxO1,phosphorylated
R10121 T15434 T15441 themeOf Foxo4,phosphorylated
R10122 T15435 T15442 themeOf MDM2,phosphorylated
R10123 T15445 T15447 themeOf TNFα,synthesis
R10124 T15446 T15448 themeOf JNK,activation
R10125 T15447 T15449 themeOf synthesis,activation

test3

Id Subject Object Predicate Lexical cue
T13688 2460-2469 Gene_expression denotes synthesis
T13687 2455-2459 Protein denotes TNFα
T13686 2447-2454 Positive_regulation denotes promote
T13685 2402-2415 Phosphorylation denotes phosphorylate
T13684 2386-2394 Positive_regulation denotes allowing
T13683 2209-2215 Protein denotes p70S6K
T13682 2199-2203 Protein denotes MDM2
T13681 2192-2197 Protein denotes Foxo4
T13680 2185-2190 Protein denotes FoxO1
T13679 2133-2140 Protein denotes Myr-Akt
T13678 2111-2125 Phosphorylation denotes phosphorylated
T13677 2026-2031 Protein denotes T308D
T13676 1810-1816 Positive_regulation denotes active
T13675 1782-1787 Protein denotes T308D
T13674 1752-1756 Protein denotes TNFα
T13673 1741-1746 Protein denotes c-Jun
T13672 1714-1729 Phosphorylation denotes phosphorylation
T13671 1584-1597 Phosphorylation denotes phosphorylate
T13670 1576-1580 Protein denotes PDK1
T13669 1530-1544 Phosphorylation denotes phosphorylated
T13668 1519-1523 Entity denotes site
T13667 1441-1455 Phosphorylation denotes phosphorylated
T13666 1406-1411 Protein denotes S473A
T13665 1339-1344 Protein denotes S473A
T13664 1315-1322 Negative_regulation denotes reduced
T13663 1238-1252 Phosphorylation denotes phosphorylated
T13662 1214-1226 Protein denotes S473D mutant
T13661 758-761 Protein denotes Akt
T13660 719-728 Negative_regulation denotes reduction
T13659 602-612 Regulation denotes regulation
T13658 579-594 Phosphorylation denotes phosphorylation
T13657 563-567 Regulation denotes role
T13656 436-451 Phosphorylation denotes phosphorylation
T13655 419-428 Positive_regulation denotes increased
T13654 328-335 Negative_regulation denotes lacking
T13653 290-298 Positive_regulation denotes required
T13652 267-279 Localization denotes localization
T13651 150-157 Protein denotes Myr-Akt
T13650 140-149 Gene_expression denotes expressed
T13649 118-127 Regulation denotes dependent
T13648 101-111 Gene_expression denotes production
T13647 96-100 Protein denotes TNFα
T13594 2455-2459 Protein denotes TNFα
T13593 2209-2215 Protein denotes p70S6K
T13592 2199-2203 Protein denotes MDM2
T13591 2192-2197 Protein denotes Foxo4
T13590 2185-2190 Protein denotes FoxO1
T13589 2133-2140 Protein denotes Myr-Akt
T13588 2026-2031 Protein denotes T308D
T13587 1782-1787 Protein denotes T308D
T13586 1752-1756 Protein denotes TNFα
T13585 1741-1746 Protein denotes c-Jun
T13584 1576-1580 Protein denotes PDK1
T13583 1406-1411 Protein denotes S473A
T13582 1339-1344 Protein denotes S473A
T13581 1214-1226 Protein denotes S473D mutant
T13580 758-761 Protein denotes Akt
T13579 150-157 Protein denotes Myr-Akt
T13578 96-100 Protein denotes TNFα
R8948 T13647 T13648 themeOf TNFα,production
R8949 T13648 T13649 themeOf production,dependent
R8950 T13650 T13649 themeOf expressed,dependent
R8951 T13651 T13650 themeOf Myr-Akt,expressed
R8952 T13652 T13653 themeOf localization,required
R8953 T13656 T13655 themeOf phosphorylation,increased
R8954 T13658 T13657 themeOf phosphorylation,role
R8955 T13662 T13663 themeOf S473D mutant,phosphorylated
R8956 T13663 T13664 themeOf phosphorylated,reduced
R8957 T13666 T13667 themeOf S473A,phosphorylated
R8958 T13673 T13672 themeOf c-Jun,phosphorylation
R8959 T13674 T13672 themeOf TNFα,phosphorylation
R8960 T13677 T13678 themeOf T308D,phosphorylated
R8961 T13679 T13678 themeOf Myr-Akt,phosphorylated
R8962 T13685 T13684 themeOf phosphorylate,allowing
R8963 T13685 T13686 causeOf phosphorylate,promote
R8964 T13687 T13688 themeOf TNFα,synthesis
R8965 T13688 T13686 themeOf synthesis,promote