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PMC:3585731 / 26676-27736 JSONTXT

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testone

Id Subject Object Predicate Lexical cue
T12716 1030-1040 Positive_regulation denotes activation
T12715 999-1007 Positive_regulation denotes required
T12714 927-942 Phosphorylation denotes phosphorylation
T12713 906-915 Negative_regulation denotes inhibited
T12712 857-866 Negative_regulation denotes knockdown
T12711 811-826 Phosphorylation denotes phosphorylation
T12710 771-781 Negative_regulation denotes inhibition
T12709 745-753 Positive_regulation denotes resulted
T12708 663-673 Negative_regulation denotes Inhibition
T12707 635-644 Regulation denotes dependent
T12706 568-577 Positive_regulation denotes increased
T12705 549-564 Phosphorylation denotes phosphorylation
T12704 368-382 Phosphorylation denotes phosphorylated
T12703 233-264 Entity denotes pleckstrin homology (PH) domain
T12702 218-225 Binding denotes binding
T12701 202-210 Positive_regulation denotes mediated
T12700 157-168 Binding denotes recruitment
T12699 108-118 Regulation denotes regulation
T12698 55-70 Phosphorylation denotes Phosphorylation
T12697 32-40 Positive_regulation denotes Increase
T12696 976-980 Protein denotes PDK1
T12695 870-874 Protein denotes PDK1
T12694 686-690 Protein denotes PDK1
T12693 657-661 Protein denotes PDK1
T12692 454-458 Protein denotes PDK1
T12691 407-452 Protein denotes 3-phosphoinositide dependent protein kinase-1
T12690 15-19 Protein denotes PDK1
R8390 T12690 T12697 causeOf PDK1,Increase
R8391 T12691 T12704 causeOf 3-phosphoinositide dependent protein kinase-1,phosphorylated
R8392 T12692 T12691 equivalentTo PDK1,3-phosphoinositide dependent protein kinase-1
R8393 T12693 T12707 causeOf PDK1,dependent
R8394 T12694 T12708 themeOf PDK1,Inhibition
R8395 T12695 T12712 themeOf PDK1,knockdown
R8396 T12696 T12715 causeOf PDK1,required
R8397 T12698 T12697 themeOf Phosphorylation,Increase
R8398 T12702 T12701 causeOf binding,mediated
R8399 T12703 T12702 themeOf pleckstrin homology (PH) domain,binding
R8400 T12705 T12706 themeOf phosphorylation,increased
R8401 T12705 T12707 themeOf phosphorylation,dependent
R8402 T12711 T12710 themeOf phosphorylation,inhibition
R8403 T12712 T12713 causeOf knockdown,inhibited
R8404 T12714 T12713 themeOf phosphorylation,inhibited
R8405 T12716 T12715 themeOf activation,required

2_test

Id Subject Object Predicate Lexical cue
23469174-20517722-90505447 498-500 20517722 denotes 35
23469174-15772071-90505448 741-743 15772071 denotes 36

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T13002 1048-1059 NN denotes necroptosis
T13001 1041-1047 IN denotes during
T13000 1030-1040 NN denotes activation
T12999 1026-1029 NN denotes Akt
T12998 1012-1025 JJ denotes non-canonical
T12997 1008-1011 IN denotes for
T12996 999-1007 VB denotes required
T12995 993-998 RB denotes still
T12994 990-992 VB denotes is
T12993 981-989 NN denotes activity
T12992 976-980 NN denotes PDK1
T12991 972-975 CC denotes and
T12990 967-971 NN denotes PI3K
T12989 965-966 -COMMA- denotes ,
T12988 956-965 RB denotes Therefore
T12987 954-955 -RRB- denotes )
T12986 953-954 NN denotes F
T12985 952-953 -COMMA- denotes ,
T12984 949-952 NN denotes S7E
T12983 944-948 NNP denotes Fig.
T12982 943-944 -LRB- denotes (
T12981 927-942 NN denotes phosphorylation
T12980 920-926 NN denotes Thr308
T12979 916-919 NN denotes Akt
T12978 906-915 VB denotes inhibited
T12977 902-905 CC denotes and
T12976 896-901 NN denotes death
T12975 891-895 IN denotes from
T12974 885-890 NN denotes cells
T12973 875-884 VB denotes protected
T12972 870-874 NN denotes PDK1
T12971 867-869 IN denotes of
T12970 857-866 NN denotes knockdown
T12969 851-856 NN denotes siRNA
T12968 849-850 -COMMA- denotes ,
T12967 841-849 RB denotes Likewise
T12966 838-839 -RRB- denotes )
T12965 833-838 NN denotes S7A–D
T12964 828-832 NN denotes Fig.
T12963 827-828 -LRB- denotes (
T12962 811-826 NN denotes phosphorylation
T12961 804-810 NN denotes Thr308
T12960 800-803 NN denotes Akt
T12959 796-799 CC denotes and
T12958 790-795 NN denotes death
T12957 785-789 NN denotes cell
T12956 782-784 IN denotes of
T12955 771-781 NN denotes inhibition
T12954 761-770 JJ denotes efficient
T12953 757-760 DT denotes the
T12952 754-756 IN denotes in
T12951 745-753 VB denotes resulted
T12950 743-744 -RRB- denotes ]
T12949 741-743 CD denotes 36
T12948 740-741 -LRB- denotes [
T12947 734-739 NN denotes BX912
T12946 730-733 CC denotes and
T12945 721-729 NN denotes LY249002
T12944 710-720 NN denotes inhibitors
T12943 701-709 JJ denotes specific
T12942 697-700 DT denotes the
T12941 691-696 VB denotes using
T12940 686-690 NN denotes PDK1
T12939 682-685 CC denotes and
T12938 677-681 NN denotes PI3K
T12937 674-676 IN denotes of
T12936 663-673 NN denotes Inhibition
T12935 657-661 NN denotes PDK1
T12934 653-656 CC denotes and
T12933 648-652 NN denotes PI3K
T12932 645-647 IN denotes on
T12931 635-644 JJ denotes dependent
T12930 629-634 RB denotes still
T12929 626-628 VB denotes is
T12928 623-625 PRP denotes it
T12927 615-622 IN denotes whether
T12926 606-614 VB denotes examined
T12925 601-605 RB denotes next
T12924 598-600 PRP denotes we
T12923 596-597 -COMMA- denotes ,
T12922 585-596 NN denotes necroptosis
T12921 578-584 IN denotes during
T12920 568-577 VB denotes increased
T12919 565-567 VB denotes is
T12918 549-564 NN denotes phosphorylation
T12917 545-548 NN denotes Akt
T12916 538-544 NN denotes Thr308
T12915 533-537 RB denotes only
T12914 528-532 IN denotes that
T12913 521-527 VB denotes showed
T12912 513-520 NN denotes results
T12911 509-512 PRP-DOLLAR- denotes our
T12910 503-508 IN denotes Since
T12909 500-501 -RRB- denotes ]
T12908 498-500 CD denotes 35
T12907 497-498 -LRB- denotes [
T12906 484-496 RB denotes respectively
T12905 482-483 -COMMA- denotes ,
T12904 481-482 -RRB- denotes )
T12903 475-481 NN denotes DNA-PK
T12902 472-474 CC denotes or
T12901 471-472 -LRB- denotes (
T12900 464-470 NN denotes mTORC2
T12899 460-463 CC denotes and
T12898 458-459 -RRB- denotes )
T12897 454-458 NN denotes PDK1
T12896 453-454 -LRB- denotes (
T12895 444-452 NN denotes kinase-1
T12894 436-443 NN denotes protein
T12893 426-435 JJ denotes dependent
T12892 407-425 NN denotes 3-phosphoinositide
T12891 404-406 IN denotes by
T12890 397-403 NN denotes Ser473
T12889 393-396 CC denotes and
T12888 386-392 NN denotes Thr308
T12887 383-385 IN denotes on
T12886 368-382 VB denotes phosphorylated
T12885 365-367 VB denotes is
T12884 361-364 NN denotes Akt
T12883 359-360 -COMMA- denotes ,
T12882 351-359 NN denotes membrane
T12881 347-350 DT denotes the
T12880 344-346 IN denotes In
T12879 341-342 -RRB- denotes )
T12878 337-341 NN denotes PIP3
T12877 336-337 -LRB- denotes (
T12876 296-335 NN denotes phosphatidylinositol-3,4,5-triphosphate
T12875 294-295 -COMMA- denotes ,
T12874 290-294 NN denotes PI3K
T12873 287-289 IN denotes of
T12872 279-286 NN denotes product
T12871 275-278 DT denotes the
T12870 272-274 TO denotes to
T12869 268-271 NN denotes Akt
T12868 265-267 IN denotes of
T12867 258-264 NN denotes domain
T12866 256-257 -RRB- denotes )
T12865 254-256 NN denotes PH
T12864 253-254 -LRB- denotes (
T12863 244-252 NN denotes homology
T12862 233-243 NN denotes pleckstrin
T12861 229-232 DT denotes the
T12860 226-228 IN denotes of
T12859 218-225 NN denotes binding
T12858 214-217 DT denotes the
T12857 211-213 IN denotes by
T12856 202-210 VB denotes mediated
T12855 199-201 VB denotes is
T12854 193-198 WDT denotes which
T12853 191-192 -COMMA- denotes ,
T12852 183-191 NN denotes membrane
T12851 176-182 NN denotes plasma
T12850 172-175 DT denotes the
T12849 169-171 TO denotes to
T12848 157-168 NN denotes recruitment
T12847 153-156 PRP-DOLLAR- denotes its
T12846 144-152 VB denotes involves
T12845 136-143 NN denotes factors
T12844 129-135 NN denotes growth
T12843 126-128 IN denotes by
T12842 122-125 NN denotes Akt
T12841 119-121 IN denotes of
T12840 108-118 NN denotes regulation
T12839 100-107 JJ denotes Typical
T12838 89-99 NN denotes Conditions
T12837 77-88 JJ denotes Necroptotic
T12832 41-43 IN denotes in
T12831 32-40 NN denotes Increase
T12830 28-31 DT denotes the
T12829 20-27 VB denotes Mediate
T12828 15-19 NN denotes PDK1
T12827 11-14 CC denotes and
T12826 0-10 NN denotes PI3-kinase
T12836 71-76 IN denotes Under
T12835 55-70 NN denotes Phosphorylation
T12834 48-54 NN denotes Thr308
T12833 44-47 NN denotes Akt
R8420 T12826 T12827 arg1Of PI3-kinase,and
R8421 T12827 T12829 arg1Of and,Mediate
R8422 T12828 T12827 arg2Of PDK1,and
R8423 T12831 T12829 arg2Of Increase,Mediate
R8424 T12831 T12830 arg1Of Increase,the
R8425 T12831 T12832 arg1Of Increase,in
R8426 T12831 T12836 arg1Of Increase,Under
R8427 T12835 T12832 arg2Of Phosphorylation,in
R8428 T12835 T12833 arg1Of Phosphorylation,Akt
R8429 T12835 T12834 arg1Of Phosphorylation,Thr308
R8430 T12838 T12836 arg2Of Conditions,Under
R8431 T12838 T12837 arg1Of Conditions,Necroptotic
R8432 T12840 T12839 arg1Of regulation,Typical
R8433 T12840 T12841 arg1Of regulation,of
R8434 T12840 T12843 arg1Of regulation,by
R8435 T12840 T12846 arg1Of regulation,involves
R8436 T12842 T12841 arg2Of Akt,of
R8437 T12845 T12843 arg2Of factors,by
R8438 T12845 T12844 arg1Of factors,growth
R8439 T12848 T12846 arg2Of recruitment,involves
R8440 T12848 T12847 arg1Of recruitment,its
R8441 T12848 T12849 arg1Of recruitment,to
R8442 T12852 T12849 arg2Of membrane,to
R8443 T12852 T12850 arg1Of membrane,the
R8444 T12852 T12851 arg1Of membrane,plasma
R8445 T12852 T12853 arg1Of membrane,","
R8446 T12852 T12854 arg1Of membrane,which
R8447 T12852 T12855 arg1Of membrane,is
R8448 T12852 T12856 arg2Of membrane,mediated
R8449 T12856 T12855 arg2Of mediated,is
R8450 T12859 T12856 arg1Of binding,mediated
R8451 T12859 T12857 arg2Of binding,by
R8452 T12859 T12858 arg1Of binding,the
R8453 T12859 T12860 arg1Of binding,of
R8454 T12859 T12868 arg1Of binding,of
R8455 T12865 T12864 arg2Of PH,(
R8456 T12866 T12864 arg3Of ),(
R8457 T12867 T12860 arg2Of domain,of
R8458 T12867 T12861 arg1Of domain,the
R8459 T12867 T12862 arg1Of domain,pleckstrin
R8460 T12867 T12863 arg1Of domain,homology
R8461 T12867 T12864 arg1Of domain,(
R8462 T12869 T12868 arg2Of Akt,of
R8463 T12869 T12870 arg1Of Akt,to
R8464 T12872 T12870 arg2Of product,to
R8465 T12872 T12871 arg1Of product,the
R8466 T12872 T12873 arg1Of product,of
R8467 T12874 T12873 arg2Of PI3K,of
R8468 T12874 T12875 arg1Of PI3K,","
R8469 T12876 T12875 arg2Of "phosphatidylinositol-3,4,5-triphosphate",","
R8470 T12876 T12877 arg1Of "phosphatidylinositol-3,4,5-triphosphate",(
R8471 T12878 T12877 arg2Of PIP3,(
R8472 T12879 T12877 arg3Of ),(
R8473 T12882 T12880 arg2Of membrane,In
R8474 T12882 T12881 arg1Of membrane,the
R8475 T12884 T12885 arg1Of Akt,is
R8476 T12884 T12886 arg2Of Akt,phosphorylated
R8477 T12886 T12880 arg1Of phosphorylated,In
R8478 T12886 T12883 arg1Of phosphorylated,","
R8479 T12886 T12885 arg2Of phosphorylated,is
R8480 T12886 T12887 arg1Of phosphorylated,on
R8481 T12886 T12907 arg1Of phosphorylated,[
R8482 T12888 T12889 arg1Of Thr308,and
R8483 T12889 T12887 arg2Of and,on
R8484 T12889 T12891 arg1Of and,by
R8485 T12890 T12889 arg2Of Ser473,and
R8486 T12895 T12892 arg1Of kinase-1,3-phosphoinositide
R8487 T12895 T12893 arg1Of kinase-1,dependent
R8488 T12895 T12894 arg1Of kinase-1,protein
R8489 T12895 T12896 arg1Of kinase-1,(
R8490 T12895 T12899 arg1Of kinase-1,and
R8491 T12897 T12896 arg2Of PDK1,(
R8492 T12898 T12896 arg3Of ),(
R8493 T12899 T12891 arg2Of and,by
R8494 T12900 T12899 arg2Of mTORC2,and
R8495 T12900 T12901 arg1Of mTORC2,(
R8496 T12900 T12905 arg1Of mTORC2,","
R8497 T12900 T12906 arg1Of mTORC2,respectively
R8498 T12903 T12901 arg2Of DNA-PK,(
R8499 T12903 T12902 arg1Of DNA-PK,or
R8500 T12904 T12901 arg3Of ),(
R8501 T12908 T12907 arg2Of 35,[
R8502 T12909 T12907 arg3Of ],[
R8503 T12912 T12911 arg1Of results,our
R8504 T12912 T12913 arg1Of results,showed
R8505 T12913 T12910 arg2Of showed,Since
R8506 T12918 T12915 arg1Of phosphorylation,only
R8507 T12918 T12916 arg1Of phosphorylation,Thr308
R8508 T12918 T12917 arg1Of phosphorylation,Akt
R8509 T12918 T12919 arg1Of phosphorylation,is
R8510 T12918 T12920 arg2Of phosphorylation,increased
R8511 T12920 T12913 arg2Of increased,showed
R8512 T12920 T12914 arg1Of increased,that
R8513 T12920 T12919 arg2Of increased,is
R8514 T12920 T12921 arg1Of increased,during
R8515 T12922 T12921 arg2Of necroptosis,during
R8516 T12924 T12926 arg1Of we,examined
R8517 T12926 T12910 arg1Of examined,Since
R8518 T12926 T12923 arg1Of examined,","
R8519 T12926 T12925 arg1Of examined,next
R8520 T12928 T12929 arg1Of it,is
R8521 T12928 T12931 arg1Of it,dependent
R8522 T12929 T12926 arg2Of is,examined
R8523 T12929 T12927 arg1Of is,whether
R8524 T12929 T12930 arg1Of is,still
R8525 T12931 T12929 arg2Of dependent,is
R8526 T12931 T12932 arg1Of dependent,on
R8527 T12933 T12934 arg1Of PI3K,and
R8528 T12934 T12932 arg2Of and,on
R8529 T12935 T12934 arg2Of PDK1,and
R8530 T12936 T12937 arg1Of Inhibition,of
R8531 T12936 T12951 arg1Of Inhibition,resulted
R8532 T12938 T12939 arg1Of PI3K,and
R8533 T12939 T12937 arg2Of and,of
R8534 T12939 T12941 arg1Of and,using
R8535 T12940 T12939 arg2Of PDK1,and
R8536 T12944 T12942 arg1Of inhibitors,the
R8537 T12944 T12943 arg1Of inhibitors,specific
R8538 T12945 T12944 arg1Of LY249002,inhibitors
R8539 T12945 T12946 arg1Of LY249002,and
R8540 T12946 T12941 arg2Of and,using
R8541 T12947 T12946 arg2Of BX912,and
R8542 T12947 T12948 arg1Of BX912,[
R8543 T12949 T12948 arg2Of 36,[
R8544 T12950 T12948 arg3Of ],[
R8545 T12951 T12952 arg1Of resulted,in
R8546 T12955 T12952 arg2Of inhibition,in
R8547 T12955 T12953 arg1Of inhibition,the
R8548 T12955 T12954 arg1Of inhibition,efficient
R8549 T12955 T12956 arg1Of inhibition,of
R8550 T12958 T12957 arg1Of death,cell
R8551 T12958 T12959 arg1Of death,and
R8552 T12959 T12956 arg2Of and,of
R8553 T12962 T12959 arg2Of phosphorylation,and
R8554 T12962 T12960 arg1Of phosphorylation,Akt
R8555 T12962 T12961 arg1Of phosphorylation,Thr308
R8556 T12962 T12963 arg1Of phosphorylation,(
R8557 T12965 T12963 arg2Of S7A–D,(
R8558 T12965 T12964 arg1Of S7A–D,Fig.
R8559 T12966 T12963 arg3Of ),(
R8560 T12970 T12969 arg1Of knockdown,siRNA
R8561 T12970 T12971 arg1Of knockdown,of
R8562 T12970 T12973 arg1Of knockdown,protected
R8563 T12970 T12978 arg1Of knockdown,inhibited
R8564 T12972 T12971 arg2Of PDK1,of
R8565 T12973 T12975 arg1Of protected,from
R8566 T12973 T12977 arg1Of protected,and
R8567 T12974 T12973 arg2Of cells,protected
R8568 T12976 T12975 arg2Of death,from
R8569 T12977 T12989 arg1Of and,","
R8570 T12978 T12977 arg2Of inhibited,and
R8571 T12978 T12988 arg1Of inhibited,Therefore
R8572 T12981 T12978 arg2Of phosphorylation,inhibited
R8573 T12981 T12979 arg1Of phosphorylation,Akt
R8574 T12981 T12980 arg1Of phosphorylation,Thr308
R8575 T12981 T12982 arg1Of phosphorylation,(
R8576 T12984 T12982 arg2Of S7E,(
R8577 T12984 T12983 arg1Of S7E,Fig.
R8578 T12984 T12985 arg1Of S7E,","
R8579 T12986 T12985 arg2Of F,","
R8580 T12987 T12982 arg3Of ),(
R8581 T12989 T12967 arg1Of ",",Likewise
R8582 T12989 T12968 arg1Of ",",","
R8583 T12990 T12991 arg1Of PI3K,and
R8584 T12991 T12994 arg1Of and,is
R8585 T12991 T12996 arg2Of and,required
R8586 T12993 T12991 arg2Of activity,and
R8587 T12993 T12992 arg1Of activity,PDK1
R8588 T12996 T12989 arg2Of required,","
R8589 T12996 T12994 arg2Of required,is
R8590 T12996 T12995 arg1Of required,still
R8591 T12996 T12997 arg1Of required,for
R8592 T13000 T12997 arg2Of activation,for
R8593 T13000 T12998 arg1Of activation,non-canonical
R8594 T13000 T12999 arg1Of activation,Akt
R8595 T13000 T13001 arg1Of activation,during
R8596 T13002 T13001 arg2Of necroptosis,during

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T12768 976-980 Protein denotes PDK1
T12767 870-874 Protein denotes PDK1
T12766 686-690 Protein denotes PDK1
T12765 657-661 Protein denotes PDK1
T12764 454-458 Protein denotes PDK1
T12763 407-452 Protein denotes 3-phosphoinositide dependent protein kinase-1
T12762 15-19 Protein denotes PDK1

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T13216 916-919 http://www.uniprot.org/uniprot/P31751 denotes Akt
T13215 800-803 http://www.uniprot.org/uniprot/P31751 denotes Akt
T13214 545-548 http://www.uniprot.org/uniprot/P31751 denotes Akt
T13213 361-364 http://www.uniprot.org/uniprot/P31751 denotes Akt
T13212 268-271 http://www.uniprot.org/uniprot/P31751 denotes Akt
T13211 122-125 http://www.uniprot.org/uniprot/P31751 denotes Akt
T13210 44-47 http://www.uniprot.org/uniprot/P31751 denotes Akt
T13209 1026-1029 http://www.uniprot.org/uniprot/P31749 denotes Akt
T13208 916-919 http://www.uniprot.org/uniprot/P31749 denotes Akt
T13207 800-803 http://www.uniprot.org/uniprot/P31749 denotes Akt
T13206 545-548 http://www.uniprot.org/uniprot/P31749 denotes Akt
T13205 361-364 http://www.uniprot.org/uniprot/P31749 denotes Akt
T13204 268-271 http://www.uniprot.org/uniprot/P31749 denotes Akt
T13203 122-125 http://www.uniprot.org/uniprot/P31749 denotes Akt
T13202 44-47 http://www.uniprot.org/uniprot/P31749 denotes Akt
T13225 1026-1029 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T13224 916-919 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T13223 800-803 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T13222 545-548 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T13221 361-364 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T13220 268-271 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T13219 122-125 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T13218 44-47 http://www.uniprot.org/uniprot/Q9Y243 denotes Akt
T13217 1026-1029 http://www.uniprot.org/uniprot/P31751 denotes Akt

GO-BP

Id Subject Object Predicate Lexical cue
T12794 896-901 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T12793 790-795 http://purl.obolibrary.org/obo/GO_0016265 denotes death
T12792 785-795 http://purl.obolibrary.org/obo/GO_0008219 denotes cell death
T12791 771-795 http://purl.obolibrary.org/obo/GO_1904093 denotes inhibition of cell death
T12790 771-795 http://purl.obolibrary.org/obo/GO_0043069 denotes inhibition of cell death
T12789 771-795 http://purl.obolibrary.org/obo/GO_1901215 denotes inhibition of cell death
T12788 1048-1059 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T12787 585-596 http://purl.obolibrary.org/obo/GO_0097528 denotes necroptosis
T12786 1048-1059 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T12785 585-596 http://purl.obolibrary.org/obo/GO_0070266 denotes necroptosis
T12784 967-971 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T12783 677-681 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T12782 648-652 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T12781 290-294 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T12780 129-135 http://purl.obolibrary.org/obo/GO_0040007 denotes growth
T12779 108-118 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T12778 927-942 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12777 811-826 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12776 549-564 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T12775 55-70 http://purl.obolibrary.org/obo/GO_0016310 denotes Phosphorylation
T12774 976-980 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T12773 870-874 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T12772 686-690 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T12771 657-661 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T12770 454-458 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T12769 15-19 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1

GO-MF

Id Subject Object Predicate Lexical cue
T12805 967-971 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T12804 677-681 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T12803 648-652 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T12802 290-294 http://purl.obolibrary.org/obo/GO_0016303 denotes PI3K
T12801 218-225 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12800 976-980 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T12799 870-874 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T12798 686-690 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T12797 657-661 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T12796 454-458 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1
T12795 15-19 http://purl.obolibrary.org/obo/GO_0004740 denotes PDK1

GO-CC

Id Subject Object Predicate Lexical cue
T12811 885-890 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T12810 785-789 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T12809 464-470 http://purl.obolibrary.org/obo/GO_0031932 denotes mTORC2
T12808 351-359 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T12807 183-191 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T12806 176-191 http://purl.obolibrary.org/obo/GO_0005886 denotes plasma membrane

sentences

Id Subject Object Predicate Lexical cue
T12752 841-1060 Sentence denotes Likewise, siRNA knockdown of PDK1 protected cells from death and inhibited Akt Thr308 phosphorylation (Fig. S7E,F) Therefore, PI3K and PDK1 activity is still required for non-canonical Akt activation during necroptosis.
T12751 663-840 Sentence denotes Inhibition of PI3K and PDK1 using the specific inhibitors LY249002 and BX912 [36] resulted in the efficient inhibition of cell death and Akt Thr308 phosphorylation (Fig. S7A–D).
T12750 503-662 Sentence denotes Since our results showed that only Thr308 Akt phosphorylation is increased during necroptosis, we next examined whether it is still dependent on PI3K and PDK1.
T12749 344-502 Sentence denotes In the membrane, Akt is phosphorylated on Thr308 and Ser473 by 3-phosphoinositide dependent protein kinase-1 (PDK1) and mTORC2 (or DNA-PK), respectively [35].
T12748 100-343 Sentence denotes Typical regulation of Akt by growth factors involves its recruitment to the plasma membrane, which is mediated by the binding of the pleckstrin homology (PH) domain of Akt to the product of PI3K, phosphatidylinositol-3,4,5-triphosphate (PIP3).
T12747 0-99 Sentence denotes PI3-kinase and PDK1 Mediate the Increase in Akt Thr308 Phosphorylation Under Necroptotic Conditions
T170 0-99 Sentence denotes PI3-kinase and PDK1 Mediate the Increase in Akt Thr308 Phosphorylation Under Necroptotic Conditions
T171 100-343 Sentence denotes Typical regulation of Akt by growth factors involves its recruitment to the plasma membrane, which is mediated by the binding of the pleckstrin homology (PH) domain of Akt to the product of PI3K, phosphatidylinositol-3,4,5-triphosphate (PIP3).
T172 344-502 Sentence denotes In the membrane, Akt is phosphorylated on Thr308 and Ser473 by 3-phosphoinositide dependent protein kinase-1 (PDK1) and mTORC2 (or DNA-PK), respectively [35].
T173 503-662 Sentence denotes Since our results showed that only Thr308 Akt phosphorylation is increased during necroptosis, we next examined whether it is still dependent on PI3K and PDK1.
T174 663-840 Sentence denotes Inhibition of PI3K and PDK1 using the specific inhibitors LY249002 and BX912 [36] resulted in the efficient inhibition of cell death and Akt Thr308 phosphorylation (Fig. S7A–D).
T175 841-1060 Sentence denotes Likewise, siRNA knockdown of PDK1 protected cells from death and inhibited Akt Thr308 phosphorylation (Fig. S7E,F) Therefore, PI3K and PDK1 activity is still required for non-canonical Akt activation during necroptosis.

simple1

Id Subject Object Predicate Lexical cue
T12825 976-980 Protein denotes PDK1
T12824 870-874 Protein denotes PDK1
T12823 686-690 Protein denotes PDK1
T12822 657-661 Protein denotes PDK1
T12821 454-458 Protein denotes PDK1
T12820 407-452 Protein denotes 3-phosphoinositide dependent protein kinase-1
T12819 15-19 Protein denotes PDK1

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T13168 857-866 Negative_regulation denotes knockdown
T13167 999-1007 Positive_regulation denotes required
T13166 663-673 Negative_regulation denotes Inhibition
T13165 368-382 Phosphorylation denotes phosphorylated
T13164 976-980 Protein denotes PDK1
T13163 870-874 Protein denotes PDK1
T13162 686-690 Protein denotes PDK1
T13161 657-661 Protein denotes PDK1
T13160 454-458 Protein denotes PDK1
T13159 407-452 Protein denotes 3-phosphoinositide dependent protein kinase-1
T13158 15-19 Protein denotes PDK1
R8752 T13160 T13165 themeOf PDK1,phosphorylated
R8753 T13162 T13166 themeOf PDK1,Inhibition
R8754 T13163 T13168 themeOf PDK1,knockdown
R8755 T13164 T13167 themeOf PDK1,required

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T13264 857-866 Negative_regulation denotes knockdown
T13263 663-673 Negative_regulation denotes Inhibition
T13262 635-644 Positive_regulation denotes dependent
T13261 368-382 Phosphorylation denotes phosphorylated
T13260 976-980 Protein denotes PDK1
T13259 870-874 Protein denotes PDK1
T13258 686-690 Protein denotes PDK1
T13257 657-661 Protein denotes PDK1
T13256 454-458 Protein denotes PDK1
T13255 407-452 Protein denotes 3-phosphoinositide dependent protein kinase-1
T13254 15-19 Protein denotes PDK1
R8801 T13255 T13261 themeOf 3-phosphoinositide dependent protein kinase-1,phosphorylated
R8802 T13256 T13261 themeOf PDK1,phosphorylated
R8803 T13257 T13262 themeOf PDK1,dependent
R8804 T13258 T13263 themeOf PDK1,Inhibition
R8805 T13259 T13264 themeOf PDK1,knockdown

DLUT931

Id Subject Object Predicate Lexical cue
T13237 999-1007 Positive_regulation denotes required
T13236 857-866 Negative_regulation denotes knockdown
T13235 745-753 Positive_regulation denotes resulted
T13234 663-673 Negative_regulation denotes Inhibition
T13233 368-382 Phosphorylation denotes phosphorylated
T13232 976-980 Protein denotes PDK1
T13231 870-874 Protein denotes PDK1
T13230 686-690 Protein denotes PDK1
T13229 657-661 Protein denotes PDK1
T13228 454-458 Protein denotes PDK1
T13227 407-452 Protein denotes 3-phosphoinositide dependent protein kinase-1
T13226 15-19 Protein denotes PDK1
R8789 T13227 T13233 causeOf 3-phosphoinositide dependent protein kinase-1,phosphorylated
R8790 T13228 T13233 themeOf PDK1,phosphorylated
R8791 T13230 T13234 themeOf PDK1,Inhibition
R8792 T13231 T13236 themeOf PDK1,knockdown
R8793 T13232 T13237 themeOf PDK1,required
R8794 T13234 T13235 themeOf Inhibition,resulted

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T13403 663-690 Negative_regulation denotes Inhibition of PI3K and PDK1
T13402 663-690 Negative_regulation denotes Inhibition of PI3K and PDK1
T13401 1012-1059 Positive_regulation denotes non-canonical Akt activation during necroptosis
T13400 800-826 Phosphorylation denotes Akt Thr308 phosphorylation
T13399 538-564 Phosphorylation denotes Thr308 Akt phosphorylation
T13398 361-459 Phosphorylation denotes Akt is phosphorylated on Thr308 and Ser473 by 3-phosphoinositide dependent protein kinase-1 (PDK1)
T13397 0-76 Regulation denotes PI3-kinase and PDK1 Mediate the Increase in Akt Thr308 Phosphorylation Under
T13396 0-76 Regulation denotes PI3-kinase and PDK1 Mediate the Increase in Akt Thr308 Phosphorylation Under
T13395 906-942 Phosphorylation denotes inhibited Akt Thr308 phosphorylation
T13394 906-942 Negative_regulation denotes inhibited Akt Thr308 phosphorylation
T13393 538-544 Entity denotes Thr308
T13392 686-690 Protein denotes PDK1
T13391 15-19 Protein denotes PDK1
T13390 916-926 Entity denotes Akt Thr308
T13389 851-853 Entity denotes si
T13388 800-810 Entity denotes Akt Thr308
T13387 976-980 Protein denotes PDK1
T13386 258-295 Entity denotes domain of Akt to the product of PI3K,
T13385 397-403 Entity denotes Ser473
T13384 254-256 Protein denotes PH
T13383 41-76 Entity denotes in Akt Thr308 Phosphorylation Under
T13382 677-681 Protein denotes PI3K
T13381 233-243 Protein denotes pleckstrin
T13380 870-874 Protein denotes PDK1
T13379 404-459 Protein denotes by 3-phosphoinositide dependent protein kinase-1 (PDK1)
T13378 657-661 Protein denotes PDK1
T13377 268-271 Protein denotes Akt
T13376 800-803 Protein denotes Akt
T13375 944-947 Protein denotes Fig
T13374 916-919 Protein denotes Akt
T13373 361-364 Protein denotes Akt
T13372 0-10 Protein denotes PI3-kinase
T13371 828-831 Protein denotes Fig
T13370 538-548 Protein denotes Thr308 Akt
T13369 454-458 Protein denotes PDK1
T13368 119-125 Protein denotes of Akt
T13367 648-652 Protein denotes PI3K
T13366 44-47 Protein denotes Akt
T13365 287-295 Protein denotes of PI3K,
T13364 337-341 Entity denotes PIP3
T13363 867-942 Entity denotes of PDK1 protected cells from death and inhibited Akt Thr308 phosphorylation
T13362 347-359 Entity denotes the membrane
T13361 386-392 Entity denotes Thr308
T13360 1026-1029 Protein denotes Akt
T13359 853-856 Protein denotes RNA
R8868 T13360 T13401 themeOf Akt,non-canonical Akt activation during necroptosis
R8869 T13361 T13373 partOf Thr308,Akt
R8870 T13361 T13398 siteOf Thr308,Akt is phosphorylated on Thr308 and Ser473 by 3-phosphoinositide dependent protein kinase-1 (PDK1)
R8871 T13370 T13399 themeOf Thr308 Akt,Thr308 Akt phosphorylation
R8872 T13372 T13396 causeOf PI3-kinase,PI3-kinase and PDK1 Mediate the Increase in Akt Thr308 Phosphorylation Under
R8873 T13373 T13398 themeOf Akt,Akt is phosphorylated on Thr308 and Ser473 by 3-phosphoinositide dependent protein kinase-1 (PDK1)
R8874 T13374 T13395 themeOf Akt,inhibited Akt Thr308 phosphorylation
R8875 T13376 T13400 themeOf Akt,Akt Thr308 phosphorylation
R8876 T13379 T13398 causeOf by 3-phosphoinositide dependent protein kinase-1 (PDK1),Akt is phosphorylated on Thr308 and Ser473 by 3-phosphoinositide dependent protein kinase-1 (PDK1)
R8877 T13382 T13403 themeOf PI3K,Inhibition of PI3K and PDK1
R8878 T13385 T13373 partOf Ser473,Akt
R8879 T13385 T13398 siteOf Ser473,Akt is phosphorylated on Thr308 and Ser473 by 3-phosphoinositide dependent protein kinase-1 (PDK1)
R8880 T13388 T13376 partOf Akt Thr308,Akt
R8881 T13388 T13400 siteOf Akt Thr308,Akt Thr308 phosphorylation
R8882 T13390 T13374 partOf Akt Thr308,Akt
R8883 T13390 T13395 siteOf Akt Thr308,inhibited Akt Thr308 phosphorylation
R8884 T13391 T13397 causeOf PDK1,PI3-kinase and PDK1 Mediate the Increase in Akt Thr308 Phosphorylation Under
R8885 T13392 T13402 themeOf PDK1,Inhibition of PI3K and PDK1
R8886 T13393 T13370 partOf Thr308,Thr308 Akt
R8887 T13393 T13399 siteOf Thr308,Thr308 Akt phosphorylation
R8888 T13395 T13394 themeOf inhibited Akt Thr308 phosphorylation,inhibited Akt Thr308 phosphorylation

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T13201 1059-1060 . denotes .
T13200 1048-1059 NN denotes necroptosis
T13199 1041-1047 IN denotes during
T13198 1030-1040 NN denotes activation
T13197 1026-1029 NNP denotes Akt
T13196 1012-1025 JJ denotes non-canonical
T13195 1008-1011 IN denotes for
T13194 999-1007 VBN denotes required
T13193 993-998 RB denotes still
T13192 990-992 VBZ denotes is
T13191 981-989 NN denotes activity
T13157 867-869 IN denotes of
T13156 857-866 NN denotes knockdown
T13155 851-856 NNP denotes siRNA
T13154 849-850 , denotes ,
T13153 841-849 RB denotes Likewise
T13152 839-840 . denotes .
T13151 838-839 -RRB- denotes )
T13150 837-838 NNP denotes D
T13149 833-836 CD denotes S7A
T13148 831-832 . denotes .
T13147 828-831 NNP denotes Fig
T13146 827-828 -LRB- denotes (
T13145 811-826 NN denotes phosphorylation
T13144 804-810 NNP denotes Thr308
T13143 800-803 NNP denotes Akt
T13142 796-799 CC denotes and
T13141 790-795 NN denotes death
T13140 785-789 NN denotes cell
T13139 782-784 IN denotes of
T13138 771-781 NN denotes inhibition
T13137 761-770 JJ denotes efficient
T13136 757-760 DT denotes the
T13135 754-756 IN denotes in
T13134 745-753 VBD denotes resulted
T13133 743-744 NNP denotes ]
T13132 741-743 CD denotes 36
T13131 740-741 NNP denotes [
T13130 734-739 NNP denotes BX912
T13129 730-733 CC denotes and
T13128 721-729 NNP denotes LY249002
T13127 710-720 NNS denotes inhibitors
T13126 701-709 JJ denotes specific
T13125 697-700 DT denotes the
T13124 691-696 VBG denotes using
T13123 686-690 NNP denotes PDK1
T13122 682-685 CC denotes and
T13121 677-681 NNP denotes PI3K
T13120 674-676 IN denotes of
T13119 663-673 NNP denotes Inhibition
T13118 661-662 . denotes .
T13117 657-661 NNP denotes PDK1
T13116 653-656 CC denotes and
T13115 648-652 NNP denotes PI3K
T13114 645-647 IN denotes on
T13113 635-644 JJ denotes dependent
T13112 629-634 RB denotes still
T13111 626-628 VBZ denotes is
T13110 623-625 PRP denotes it
T13109 615-622 IN denotes whether
T13108 606-614 VBD denotes examined
T13107 601-605 JJ denotes next
T13106 598-600 PRP denotes we
T13105 596-597 , denotes ,
T13104 585-596 NN denotes necroptosis
T13103 578-584 IN denotes during
T13102 568-577 VBN denotes increased
T13101 565-567 VBZ denotes is
T13100 549-564 NN denotes phosphorylation
T13099 545-548 NNP denotes Akt
T13098 538-544 CD denotes Thr308
T13097 533-537 RB denotes only
T13096 528-532 IN denotes that
T13095 521-527 VBD denotes showed
T13094 513-520 NNS denotes results
T13093 509-512 PRP$ denotes our
T13090 500-501 NNP denotes ]
T13089 498-500 CD denotes 35
T13088 497-498 NNP denotes [
T13087 484-496 RB denotes respectively
T13086 482-483 , denotes ,
T13085 481-482 -RRB- denotes )
T13084 475-481 NNP denotes DNA-PK
T13083 472-474 CC denotes or
T13082 471-472 -LRB- denotes (
T13081 464-470 NNP denotes mTORC2
T13080 460-463 CC denotes and
T13079 458-459 -RRB- denotes )
T13078 454-458 CD denotes PDK1
T13077 453-454 -LRB- denotes (
T13076 444-452 NN denotes kinase-1
T13075 436-443 NN denotes protein
T13074 426-435 JJ denotes dependent
T13073 407-425 JJ denotes 3-phosphoinositide
T13072 404-406 IN denotes by
T13071 397-403 NNP denotes Ser473
T13070 393-396 CC denotes and
T13069 386-392 NNP denotes Thr308
T13068 383-385 IN denotes on
T13052 294-295 , denotes ,
T13051 290-294 NNP denotes PI3K
T13050 287-289 IN denotes of
T13049 279-286 NN denotes product
T13048 275-278 DT denotes the
T13047 272-274 TO denotes to
T13046 268-271 NNP denotes Akt
T13045 265-267 IN denotes of
T13044 258-264 NN denotes domain
T13043 256-257 -RRB- denotes )
T13042 254-256 NNP denotes PH
T13041 253-254 -LRB- denotes (
T13040 244-252 NN denotes homology
T13039 233-243 NN denotes pleckstrin
T13038 229-232 DT denotes the
T13037 226-228 IN denotes of
T13036 218-225 JJ denotes binding
T13035 214-217 DT denotes the
T13034 211-213 IN denotes by
T13033 202-210 VBN denotes mediated
T13032 199-201 VBZ denotes is
T13031 193-198 WDT denotes which
T13030 191-192 , denotes ,
T13029 183-191 NN denotes membrane
T13028 176-182 NN denotes plasma
T13027 172-175 DT denotes the
T13026 169-171 TO denotes to
T13025 157-168 NN denotes recruitment
T13024 153-156 PRP$ denotes its
T13023 144-152 VBZ denotes involves
T13022 136-143 NNS denotes factors
T13021 129-135 NN denotes growth
T13020 126-128 IN denotes by
T13019 122-125 NNP denotes Akt
T13018 119-121 IN denotes of
T13017 108-118 NN denotes regulation
T13016 100-107 JJ denotes Typical
T13015 89-99 NNP denotes Conditions
T13014 77-88 NNP denotes Necroptotic
T13013 71-76 IN denotes Under
T13012 55-70 NNP denotes Phosphorylation
T13011 48-54 NNP denotes Thr308
T13010 44-47 NNP denotes Akt
T13009 41-43 IN denotes in
T13008 32-40 VB denotes Increase
T13007 28-31 DT denotes the
T13006 20-27 VB denotes Mediate
T13005 15-19 NNP denotes PDK1
T13004 11-14 CC denotes and
T13003 0-10 NN denotes PI3-kinase
T13067 368-382 VBN denotes phosphorylated
T13066 365-367 VBZ denotes is
T13065 361-364 NNP denotes Akt
T13064 359-360 , denotes ,
T13063 351-359 NN denotes membrane
T13062 347-350 DT denotes the
T13061 344-346 IN denotes In
T13060 342-343 . denotes .
T13059 341-342 -RRB- denotes )
T13058 337-341 CD denotes PIP3
T13057 336-337 -LRB- denotes (
T13056 323-335 NN denotes triphosphate
T13055 322-323 : denotes -
T13054 318-322 CD denotes ,4,5
T13053 296-318 JJ denotes phosphatidylinositol-3
T13092 503-508 IN denotes Since
T13091 501-502 . denotes .
T13190 976-980 NNP denotes PDK1
T13189 972-975 CC denotes and
T13188 967-971 NNP denotes PI3K
T13187 965-966 , denotes ,
T13186 956-965 RB denotes Therefore
T13185 954-955 -RRB- denotes )
T13184 953-954 NN denotes F
T13183 952-953 , denotes ,
T13182 949-952 CD denotes S7E
T13181 947-948 . denotes .
T13180 944-947 NNP denotes Fig
T13179 943-944 -LRB- denotes (
T13178 927-942 NN denotes phosphorylation
T13177 920-926 NNP denotes Thr308
T13176 916-919 NNP denotes Akt
T13175 906-915 VBD denotes inhibited
T13174 902-905 CC denotes and
T13173 896-901 NN denotes death
T13172 891-895 IN denotes from
T13171 885-890 NNS denotes cells
T13170 875-884 JJ denotes protected
T13169 870-874 CD denotes PDK1
R8597 T13003 T13006 nsubj PI3-kinase,Mediate
R8598 T13004 T13003 cc and,PI3-kinase
R8599 T13005 T13003 conj PDK1,PI3-kinase
R8600 T13006 T13006 ROOT Mediate,Mediate
R8601 T13007 T13008 det the,Increase
R8602 T13008 T13006 dobj Increase,Mediate
R8603 T13009 T13008 prep in,Increase
R8604 T13010 T13012 compound Akt,Phosphorylation
R8605 T13011 T13012 compound Thr308,Phosphorylation
R8606 T13012 T13009 pobj Phosphorylation,in
R8607 T13013 T13023 prep Under,involves
R8608 T13014 T13015 nmod Necroptotic,Conditions
R8609 T13015 T13017 nmod Conditions,regulation
R8610 T13016 T13017 amod Typical,regulation
R8611 T13017 T13013 pobj regulation,Under
R8612 T13018 T13017 prep of,regulation
R8613 T13019 T13018 pobj Akt,of
R8614 T13020 T13017 prep by,regulation
R8615 T13021 T13022 compound growth,factors
R8616 T13022 T13020 pobj factors,by
R8617 T13023 T13023 ROOT involves,involves
R8618 T13024 T13025 poss its,recruitment
R8619 T13025 T13023 dobj recruitment,involves
R8620 T13026 T13025 prep to,recruitment
R8621 T13027 T13029 det the,membrane
R8622 T13028 T13029 compound plasma,membrane
R8623 T13029 T13026 pobj membrane,to
R8624 T13030 T13029 punct ",",membrane
R8625 T13031 T13033 nsubjpass which,mediated
R8626 T13032 T13033 auxpass is,mediated
R8627 T13033 T13029 relcl mediated,membrane
R8628 T13034 T13033 agent by,mediated
R8629 T13035 T13036 det the,binding
R8630 T13036 T13034 pobj binding,by
R8631 T13037 T13036 prep of,binding
R8632 T13038 T13040 det the,homology
R8633 T13039 T13040 compound pleckstrin,homology
R8634 T13040 T13037 pobj homology,of
R8635 T13041 T13040 punct (,homology
R8636 T13042 T13040 appos PH,homology
R8637 T13043 T13040 punct ),homology
R8638 T13044 T13029 conj domain,membrane
R8639 T13045 T13044 prep of,domain
R8640 T13046 T13045 pobj Akt,of
R8641 T13047 T13025 prep to,recruitment
R8642 T13048 T13049 det the,product
R8643 T13049 T13047 pobj product,to
R8644 T13050 T13049 prep of,product
R8645 T13051 T13050 pobj PI3K,of
R8646 T13052 T13025 punct ",",recruitment
R8647 T13053 T13056 nmod phosphatidylinositol-3,triphosphate
R8648 T13054 T13056 nummod ",4,5",triphosphate
R8649 T13055 T13056 punct -,triphosphate
R8650 T13056 T13025 appos triphosphate,recruitment
R8651 T13057 T13056 punct (,triphosphate
R8652 T13058 T13056 appos PIP3,triphosphate
R8653 T13059 T13056 punct ),triphosphate
R8654 T13060 T13023 punct .,involves
R8655 T13061 T13066 prep In,is
R8656 T13062 T13063 det the,membrane
R8657 T13063 T13061 pobj membrane,In
R8658 T13064 T13066 punct ",",is
R8659 T13065 T13066 nsubj Akt,is
R8660 T13066 T13066 ROOT is,is
R8661 T13067 T13066 acomp phosphorylated,is
R8662 T13068 T13067 prep on,phosphorylated
R8663 T13069 T13068 pobj Thr308,on
R8664 T13070 T13069 cc and,Thr308
R8665 T13071 T13069 conj Ser473,Thr308
R8666 T13072 T13067 agent by,phosphorylated
R8667 T13073 T13076 amod 3-phosphoinositide,kinase-1
R8668 T13074 T13076 amod dependent,kinase-1
R8669 T13075 T13076 compound protein,kinase-1
R8670 T13076 T13072 pobj kinase-1,by
R8671 T13077 T13078 punct (,PDK1
R8672 T13078 T13076 appos PDK1,kinase-1
R8673 T13079 T13076 punct ),kinase-1
R8674 T13080 T13067 cc and,phosphorylated
R8675 T13081 T13067 conj mTORC2,phosphorylated
R8676 T13082 T13081 punct (,mTORC2
R8677 T13083 T13081 cc or,mTORC2
R8678 T13084 T13081 conj DNA-PK,mTORC2
R8679 T13085 T13081 punct ),mTORC2
R8680 T13086 T13081 punct ",",mTORC2
R8681 T13087 T13088 advmod respectively,[
R8682 T13088 T13081 conj [,mTORC2
R8683 T13089 T13090 nummod 35,]
R8684 T13090 T13088 appos ],[
R8685 T13091 T13066 punct .,is
R8686 T13092 T13095 mark Since,showed
R8687 T13093 T13094 poss our,results
R8688 T13094 T13095 nsubj results,showed
R8689 T13095 T13108 advcl showed,examined
R8690 T13096 T13102 mark that,increased
R8691 T13097 T13098 advmod only,Thr308
R8692 T13098 T13100 nummod Thr308,phosphorylation
R8693 T13099 T13100 compound Akt,phosphorylation
R8694 T13100 T13102 nsubjpass phosphorylation,increased
R8695 T13101 T13102 auxpass is,increased
R8696 T13102 T13095 ccomp increased,showed
R8697 T13103 T13102 prep during,increased
R8698 T13104 T13103 pobj necroptosis,during
R8699 T13105 T13108 punct ",",examined
R8700 T13106 T13108 nsubj we,examined
R8701 T13107 T13108 advmod next,examined
R8702 T13108 T13108 ROOT examined,examined
R8703 T13109 T13111 mark whether,is
R8704 T13110 T13111 nsubj it,is
R8705 T13111 T13108 ccomp is,examined
R8706 T13112 T13111 advmod still,is
R8707 T13113 T13111 acomp dependent,is
R8708 T13114 T13113 prep on,dependent
R8709 T13115 T13114 pobj PI3K,on
R8710 T13116 T13115 cc and,PI3K
R8711 T13117 T13115 conj PDK1,PI3K
R8712 T13118 T13108 punct .,examined
R8713 T13119 T13134 nsubj Inhibition,resulted
R8714 T13120 T13119 prep of,Inhibition
R8715 T13121 T13120 pobj PI3K,of
R8716 T13122 T13121 cc and,PI3K
R8717 T13123 T13121 conj PDK1,PI3K
R8718 T13124 T13119 acl using,Inhibition
R8719 T13125 T13127 det the,inhibitors
R8720 T13126 T13127 amod specific,inhibitors
R8721 T13127 T13124 dobj inhibitors,using
R8722 T13128 T13134 nsubj LY249002,resulted
R8723 T13129 T13128 cc and,LY249002
R8724 T13130 T13131 compound BX912,[
R8725 T13131 T13128 conj [,LY249002
R8726 T13132 T13133 compound 36,]
R8727 T13133 T13128 conj ],LY249002
R8728 T13134 T13134 ROOT resulted,resulted
R8729 T13135 T13134 prep in,resulted
R8730 T13136 T13138 det the,inhibition
R8731 T13137 T13138 amod efficient,inhibition
R8732 T13138 T13135 pobj inhibition,in
R8733 T13139 T13138 prep of,inhibition
R8734 T13140 T13141 compound cell,death
R8735 T13141 T13139 pobj death,of
R8736 T13142 T13134 cc and,resulted
R8737 T13143 T13145 compound Akt,phosphorylation
R8738 T13144 T13145 compound Thr308,phosphorylation
R8739 T13145 T13134 conj phosphorylation,resulted
R8740 T13146 T13147 punct (,Fig
R8741 T13147 T13145 appos Fig,phosphorylation
R8742 T13148 T13134 punct .,resulted
R8743 T13149 T13149 ROOT S7A,S7A
R8744 T13150 T13149 appos D,S7A
R8745 T13151 T13149 punct ),S7A
R8746 T13152 T13149 punct .,S7A
R8747 T13153 T13175 advmod Likewise,inhibited
R8748 T13154 T13175 punct ",",inhibited
R8749 T13155 T13156 compound siRNA,knockdown
R8750 T13156 T13175 nsubj knockdown,inhibited
R8751 T13157 T13156 prep of,knockdown
R8756 T13169 T13171 nummod PDK1,cells
R8757 T13170 T13171 amod protected,cells
R8758 T13171 T13157 pobj cells,of
R8759 T13172 T13156 prep from,knockdown
R8760 T13173 T13172 pobj death,from
R8761 T13174 T13156 cc and,knockdown
R8762 T13175 T13175 ROOT inhibited,inhibited
R8763 T13176 T13178 compound Akt,phosphorylation
R8764 T13177 T13178 compound Thr308,phosphorylation
R8765 T13178 T13175 dobj phosphorylation,inhibited
R8766 T13179 T13180 punct (,Fig
R8767 T13180 T13178 appos Fig,phosphorylation
R8768 T13181 T13175 punct .,inhibited
R8769 T13182 T13182 ROOT S7E,S7E
R8770 T13183 T13184 punct ",",F
R8771 T13184 T13182 appos F,S7E
R8772 T13185 T13182 punct ),S7E
R8773 T13186 T13194 advmod Therefore,required
R8774 T13187 T13194 punct ",",required
R8775 T13188 T13194 nsubjpass PI3K,required
R8776 T13189 T13188 cc and,PI3K
R8777 T13190 T13191 compound PDK1,activity
R8778 T13191 T13188 conj activity,PI3K
R8779 T13192 T13194 auxpass is,required
R8780 T13193 T13194 advmod still,required
R8781 T13194 T13194 ROOT required,required
R8782 T13195 T13194 prep for,required
R8783 T13196 T13198 amod non-canonical,activation
R8784 T13197 T13198 compound Akt,activation
R8785 T13198 T13195 pobj activation,for
R8786 T13199 T13194 prep during,required
R8787 T13200 T13199 pobj necroptosis,during
R8788 T13201 T13194 punct .,required

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T13311 906-915 Negative_regulation denotes inhibited
T13310 999-1007 Positive_regulation denotes required
T13309 999-1007 Positive_regulation denotes required
T13308 927-942 Phosphorylation denotes phosphorylation
T13307 857-866 Negative_regulation denotes knockdown
T13306 976-980 Protein denotes PDK1
T13283 538-548 Protein denotes Thr308 Akt
T13282 368-382 Phosphorylation denotes phosphorylated
T13281 368-382 Phosphorylation denotes phosphorylated
T13280 368-382 Phosphorylation denotes phosphorylated
T13279 368-382 Phosphorylation denotes phosphorylated
T13278 464-470 Protein denotes mTORC2
T13277 454-458 Protein denotes PDK1
T13276 436-452 Protein denotes protein kinase-1
T13275 361-364 Protein denotes Akt
T13274 218-225 Binding denotes binding
T13273 258-264 Entity denotes domain
T13272 108-118 Regulation denotes regulation
T13271 290-294 Protein denotes PI3K
T13270 268-271 Protein denotes Akt
T13269 254-256 Protein denotes PH
T13268 233-252 Protein denotes pleckstrin homology
T13267 122-125 Protein denotes Akt
T13266 15-19 Protein denotes PDK1
T13265 0-10 Protein denotes PI3-kinase
T13305 967-971 Protein denotes PI3K
T13304 916-926 Protein denotes Akt Thr308
T13303 870-874 Protein denotes PDK1
T13302 771-781 Negative_regulation denotes inhibition
T13301 771-781 Negative_regulation denotes inhibition
T13300 771-781 Negative_regulation denotes inhibition
T13299 811-826 Phosphorylation denotes phosphorylation
T13298 811-826 Phosphorylation denotes phosphorylation
T13297 811-826 Phosphorylation denotes phosphorylation
T13296 663-673 Negative_regulation denotes Inhibition
T13295 663-673 Negative_regulation denotes Inhibition
T13294 833-838 Protein denotes S7A–D
T13293 828-831 Protein denotes Fig
T13292 800-810 Protein denotes Akt Thr308
T13291 686-690 Protein denotes PDK1
T13290 677-681 Protein denotes PI3K
T13289 635-644 Positive_regulation denotes dependent
T13288 635-644 Positive_regulation denotes dependent
T13287 568-577 Positive_regulation denotes increased
T13286 549-564 Phosphorylation denotes phosphorylation
T13285 657-661 Protein denotes PDK1
T13284 648-652 Protein denotes PI3K
R8806 T13267 T13272 themeOf Akt,regulation
R8807 T13268 T13273 partOf pleckstrin homology,domain
R8808 T13269 T13273 partOf PH,domain
R8809 T13270 T13274 themeOf Akt,binding
R8810 T13270 T13273 partOf Akt,domain
R8811 T13271 T13274 themeOf PI3K,binding
R8812 T13273 T13274 Site domain,binding
R8813 T13275 T13279 themeOf Akt,phosphorylated
R8814 T13276 T13280 themeOf protein kinase-1,phosphorylated
R8815 T13277 T13281 themeOf PDK1,phosphorylated
R8816 T13278 T13282 themeOf mTORC2,phosphorylated
R8817 T13283 T13286 themeOf Thr308 Akt,phosphorylation
R8818 T13284 T13288 themeOf PI3K,dependent
R8819 T13285 T13289 themeOf PDK1,dependent
R8820 T13286 T13287 themeOf phosphorylation,increased
R8821 T13290 T13295 themeOf PI3K,Inhibition
R8822 T13291 T13296 themeOf PDK1,Inhibition
R8823 T13292 T13297 themeOf Akt Thr308,phosphorylation
R8824 T13293 T13298 themeOf Fig,phosphorylation
R8825 T13294 T13299 themeOf S7A–D,phosphorylation
R8826 T13297 T13300 themeOf phosphorylation,inhibition
R8827 T13298 T13301 themeOf phosphorylation,inhibition
R8828 T13299 T13302 themeOf phosphorylation,inhibition
R8829 T13303 T13307 themeOf PDK1,knockdown
R8830 T13304 T13308 themeOf Akt Thr308,phosphorylation
R8831 T13305 T13309 themeOf PI3K,required
R8832 T13306 T13310 themeOf PDK1,required
R8833 T13307 T13309 causeOf knockdown,required
R8834 T13307 T13310 causeOf knockdown,required
R8835 T13307 T13311 causeOf knockdown,inhibited
R8836 T13308 T13311 themeOf phosphorylation,inhibited

test3

Id Subject Object Predicate Lexical cue
T12746 1030-1040 Positive_regulation denotes activation
T12745 976-980 Protein denotes PDK1
T12744 927-942 Phosphorylation denotes phosphorylation
T12743 906-915 Negative_regulation denotes inhibited
T12742 870-874 Protein denotes PDK1
T12741 811-826 Phosphorylation denotes phosphorylation
T12740 686-690 Protein denotes PDK1
T12739 657-661 Protein denotes PDK1
T12738 635-644 Regulation denotes dependent
T12737 568-577 Positive_regulation denotes increased
T12736 549-564 Phosphorylation denotes phosphorylation
T12735 454-458 Protein denotes PDK1
T12734 407-452 Protein denotes 3-phosphoinositide dependent protein kinase-1
T12733 368-382 Phosphorylation denotes phosphorylated
T12732 254-264 Entity denotes PH) domain
T12731 233-252 Entity denotes pleckstrin homology
T12730 218-225 Binding denotes binding
T12729 202-210 Positive_regulation denotes mediated
T12728 157-168 Binding denotes recruitment
T12727 108-118 Regulation denotes regulation
T12726 55-70 Phosphorylation denotes Phosphorylation
T12725 32-40 Positive_regulation denotes Increase
T12724 15-19 Protein denotes PDK1
T12723 976-980 Protein denotes PDK1
T12722 870-874 Protein denotes PDK1
T12721 686-690 Protein denotes PDK1
T12720 657-661 Protein denotes PDK1
T12719 454-458 Protein denotes PDK1
T12718 407-452 Protein denotes 3-phosphoinositide dependent protein kinase-1
T12717 15-19 Protein denotes PDK1
R8406 T12724 T12725 causeOf PDK1,Increase
R8407 T12726 T12725 themeOf Phosphorylation,Increase
R8408 T12728 T12729 themeOf recruitment,mediated
R8409 T12731 T12730 themeOf pleckstrin homology,binding
R8410 T12734 T12733 causeOf 3-phosphoinositide dependent protein kinase-1,phosphorylated
R8411 T12735 T12734 equivalentTo PDK1,3-phosphoinositide dependent protein kinase-1
R8412 T12736 T12737 themeOf phosphorylation,increased
R8413 T12736 T12738 themeOf phosphorylation,dependent
R8414 T12737 T12738 themeOf increased,dependent
R8415 T12739 T12738 causeOf PDK1,dependent
R8416 T12744 T12743 themeOf phosphorylation,inhibited