PMC:3585731 / 19836-25597 JSON TXT

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testone

Id	Subject	Object	Predicate	Lexical cue
T30651	5058-5067	Negative_regulation	denotes	knockdown
T30650	5184-5189	Protein	denotes	mTNFα
T30649	5137-5141	Protein	denotes	TNFα
T30648	5012-5016	Protein	denotes	TNFα
T30647	4906-4910	Protein	denotes	TNFα
T30646	4854-4857	Protein	denotes	18S
T30645	4818-4823	Protein	denotes	mTNFα
T30644	4738-4742	Protein	denotes	bFGF
T30643	4628-4632	Protein	denotes	TNFα
T30220	1858-1867	Negative_regulation	denotes	knockdown
T30219	1752-1762	Negative_regulation	denotes	inhibitors
T30218	1928-1932	Protein	denotes	TNFα
T30217	1715-1719	Protein	denotes	TNFα
T30216	1562-1566	Protein	denotes	bFGF
T30215	1554-1558	Protein	denotes	bFGF
T30214	1454-1458	Protein	denotes	TNFα
T8963	5734-5742	Positive_regulation	denotes	increase
T8962	5611-5621	Positive_regulation	denotes	stimulated
T8961	5544-5550	Regulation	denotes	effect
T8960	5526-5536	Negative_regulation	denotes	inhibitors
T8959	5443-5450	Negative_regulation	denotes	reduced
T8958	5417-5426	Negative_regulation	denotes	knockdown
T8957	5411-5416	Negative_regulation	denotes	siRNA
T8956	5328-5340	Positive_regulation	denotes	upregulation
T8955	5310-5320	Positive_regulation	denotes	contribute
T8954	4379-4388	Positive_regulation	denotes	increased
T8953	4330-4342	Positive_regulation	denotes	upregulation
T8952	4314-4320	Positive_regulation	denotes	caused
T8951	4277-4285	Positive_regulation	denotes	increase
T8950	4164-4173	Positive_regulation	denotes	induction
T8949	4149-4158	Positive_regulation	denotes	triggered
T8948	4045-4054	Positive_regulation	denotes	increased
T8947	3974-3982	Positive_regulation	denotes	increase
T8946	3911-3921	Positive_regulation	denotes	contribute
T8945	3809-3818	Gene_expression	denotes	synthesis
T8944	3799-3808	Positive_regulation	denotes	increased
T8943	3631-3643	Positive_regulation	denotes	upregulation
T8942	3415-3422	Binding	denotes	targets
T8941	3247-3257	Negative_regulation	denotes	attenuated
T8940	3223-3232	Negative_regulation	denotes	knockdown
T8939	3178-3193	Phosphorylation	denotes	phosphorylation
T8938	3169-3174	Negative_regulation	denotes	block
T8937	2613-2622	Negative_regulation	denotes	Knockdown
T8936	2580-2589	Negative_regulation	denotes	inhibited
T8935	2541-2550	Negative_regulation	denotes	inhibitor
T8934	2373-2382	Negative_regulation	denotes	inhibitor
T8933	2335-2345	Negative_regulation	denotes	inhibition
T8932	1093-1102	Negative_regulation	denotes	abrogated
T8931	1060-1069	Positive_regulation	denotes	increases
T8930	743-758	Phosphorylation	denotes	phosphorylation
T8929	727-735	Positive_regulation	denotes	increase
T8928	268-283	Phosphorylation	denotes	phosphorylation
T8927	252-260	Positive_regulation	denotes	increase
T8926	144-159	Phosphorylation	denotes	phosphorylation
T8925	125-133	Positive_regulation	denotes	increase
T8924	5746-5750	Protein	denotes	TNFα
T8923	5627-5631	Protein	denotes	bFGF
T8922	5568-5572	Protein	denotes	TNFα
T8921	5513-5517	Protein	denotes	RIP1
T8920	5451-5455	Protein	denotes	TNFα
T8919	5344-5348	Protein	denotes	TNFα
T8918	4535-4539	Protein	denotes	TNFα
T8917	4346-4350	Protein	denotes	TNFα
T8916	4177-4181	Protein	denotes	TNFα
T8915	4138-4142	Protein	denotes	bFGF
T8914	4093-4097	Protein	denotes	RIP1
T8913	4028-4032	Protein	denotes	TNFα
T8912	3986-3990	Protein	denotes	TNFα
T8911	3959-3963	Protein	denotes	RIP1
T8910	3925-3929	Protein	denotes	TNFα
T8909	3822-3826	Protein	denotes	TNFα
T8908	3647-3651	Protein	denotes	TNFα
T8907	3586-3590	Protein	denotes	RIP1
T8906	3338-3340	Protein	denotes	S6
T8905	3331-3337	Protein	denotes	p70S6K
T8904	3236-3238	Protein	denotes	S6
T8903	3175-3177	Protein	denotes	S6
T8902	3089-3095	Protein	denotes	p70S6K
T8901	2911-2913	Protein	denotes	S6
T8900	2861-2873	Protein	denotes	p70S6 kinase
T8899	2780-2784	Protein	denotes	TNFα
T8898	2405-2411	Protein	denotes	Raptor
T8897	1288-1292	Protein	denotes	RIP1
T8896	793-799	Protein	denotes	pFoxO1
T8895	621-623	Protein	denotes	S6
T8894	596-602	Protein	denotes	p70S6K
T8893	593-594	Protein	denotes	β
T8892	586-592	Protein	denotes	GSK-3α
T8891	578-584	Protein	denotes	FoxO3a
T8890	523-527	Protein	denotes	MDM2
T8889	516-521	Protein	denotes	FoxO4
T8888	509-514	Protein	denotes	FoxO1
T8887	479-481	Protein	denotes	S6
T8886	470-476	Protein	denotes	p70S6K
T8885	437-468	Protein	denotes	p70 ribosomal protein S6 Kinase
T8884	397-401	Protein	denotes	MDM2
T8883	380-395	Protein	denotes	double minute 2
R5799	T8883	T8928	themeOf	double minute 2,phosphorylation
R5800	T8884	T8883	equivalentTo	MDM2,double minute 2
R5801	T8885	T8883	equivalentTo	p70 ribosomal protein S6 Kinase,double minute 2
R5802	T8887	T8928	themeOf	S6,phosphorylation
R5803	T8898	T8934	themeOf	Raptor,inhibitor
R5804	T8903	T8939	themeOf	S6,phosphorylation
R5805	T8904	T8940	themeOf	S6,knockdown
R5806	T8908	T8943	themeOf	TNFα,upregulation
R5807	T8909	T8945	themeOf	TNFα,synthesis
R5808	T8912	T8947	themeOf	TNFα,increase
R5809	T8915	T8949	causeOf	bFGF,triggered
R5810	T8916	T8950	themeOf	TNFα,induction
R5811	T8917	T8953	themeOf	TNFα,upregulation
R5812	T8919	T8956	themeOf	TNFα,upregulation
R5813	T8921	T8960	themeOf	RIP1,inhibitors
R5814	T8923	T8962	themeOf	bFGF,stimulated
R5815	T8926	T8925	themeOf	phosphorylation,increase
R5816	T8928	T8927	themeOf	phosphorylation,increase
R5817	T8930	T8929	themeOf	phosphorylation,increase
R5818	T8939	T8938	themeOf	phosphorylation,block
R5819	T8940	T8941	causeOf	knockdown,attenuated
R5820	T8945	T8944	themeOf	synthesis,increased
R5821	T8950	T8949	themeOf	induction,triggered
R5822	T8953	T8952	themeOf	upregulation,caused
R5823	T8953	T8954	themeOf	upregulation,increased
R5824	T8956	T8955	themeOf	upregulation,contribute

2_test

Id	Subject	Object	Predicate	Lexical cue
23469174-18955974-90505435	2209-2211	18955974	denotes	28
23469174-12150925-90505436	2413-2415	12150925	denotes	29
23469174-20860370-90505437	2514-2516	20860370	denotes	30
23469174-16697955-90505438	2559-2561	16697955	denotes	31
23469174-12374276-90505439	2915-2917	12374276	denotes	32
23469174-19109899-90505440	2957-2959	19109899	denotes	10
23469174-20704563-90505441	3108-3110	20704563	denotes	33
23469174-19109899-90505442	3693-3695	19109899	denotes	10

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T30859	5249-5256	VB	denotes	plotted
T30858	5245-5248	VB	denotes	was
T30857	5234-5244	NN	denotes	average±SD
T30856	5232-5233	-COMMA-	denotes	,
T30855	5226-5232	NN	denotes	graphs
T30854	5222-5225	DT	denotes	all
T30853	5219-5221	IN	denotes	In
T30852	5216-5217	-RRB-	denotes	)
T30851	5215-5216	NN	denotes	F
T30850	5214-5215	-COMMA-	denotes	,
T30849	5213-5214	NN	denotes	E
T30848	5212-5213	-LRB-	denotes	(
T30847	5207-5211	NN	denotes	blot
T30846	5199-5206	JJ	denotes	western
T30845	5196-5198	CC	denotes	or
T30844	5194-5195	-RRB-	denotes	)
T30843	5193-5194	NN	denotes	D
T30842	5192-5193	-COMMA-	denotes	,
T30841	5191-5192	NN	denotes	C
T30840	5190-5191	-LRB-	denotes	(
T30839	5184-5189	NN	denotes	mTNFα
T30838	5181-5183	IN	denotes	of
T30837	5172-5180	NN	denotes	analysis
T30836	5164-5171	NN	denotes	qRT-PCR
T30835	5161-5163	IN	denotes	by
T30834	5152-5160	VB	denotes	followed
T30833	5150-5151	-COMMA-	denotes	,
T30832	5148-5150	NN	denotes	hr
T30831	5146-5147	CD	denotes	9
T30830	5142-5145	IN	denotes	for
T30829	5137-5141	NN	denotes	TNFα
T30828	5134-5136	CC	denotes	or
T30827	5125-5133	NN	denotes	zVAD.fmk
T30826	5120-5124	IN	denotes	with
T30825	5109-5119	VB	denotes	stimulated
T30824	5104-5108	VB	denotes	were
T30823	5102-5103	-RRB-	denotes	)
T30822	5101-5102	NN	denotes	F
T30821	5100-5101	-COMMA-	denotes	,
T30820	5099-5100	NN	denotes	D
T30819	5098-5099	-LRB-	denotes	(
T30818	5093-5097	NN	denotes	mTOR
T30817	5090-5092	CC	denotes	or
T30816	5088-5089	-RRB-	denotes	)
T30815	5087-5088	NN	denotes	E
T30814	5086-5087	-COMMA-	denotes	,
T30813	5085-5086	NN	denotes	C
T30812	5084-5085	-LRB-	denotes	(
T30811	5075-5083	NN	denotes	isoforms
T30810	5071-5074	NN	denotes	Akt
T30809	5068-5070	IN	denotes	of
T30808	5058-5067	NN	denotes	knockdown
T30807	5052-5057	NN	denotes	siRNA
T30735	4686-4691	NN	denotes	Cells
T30734	4684-4685	-RRB-	denotes	)
T30733	4683-4684	NN	denotes	A
T30732	4682-4683	-LRB-	denotes	(
T30731	4669-4680	NN	denotes	necroptosis
T30730	4662-4668	IN	denotes	during
T30729	4651-4661	NN	denotes	activation
T30728	4647-4650	NN	denotes	JNK
T30727	4643-4646	CC	denotes	and
T30726	4633-4642	NN	denotes	synthesis
T30725	4628-4632	NN	denotes	TNFα
T30724	4618-4627	JJ	denotes	autocrine
T30723	4610-4617	NN	denotes	control
T30722	4603-4609	NN	denotes	mTORC1
T30721	4599-4602	CC	denotes	and
T30720	4595-4598	NN	denotes	Akt
T30400	2044-2051	VB	denotes	plotted
T30399	2040-2043	VB	denotes	was
T30398	2029-2039	NN	denotes	average±SD
T30397	2027-2028	-COMMA-	denotes	,
T30396	2021-2027	NN	denotes	graphs
T30395	2017-2020	DT	denotes	all
T30394	2014-2016	IN	denotes	In
T30393	2001-2012	NN	denotes	necroptosis
T30392	1998-2000	IN	denotes	of
T30391	1987-1997	NN	denotes	activation
T30390	1981-1986	IN	denotes	after
T30389	1978-1980	NN	denotes	hr
T30388	1975-1977	CD	denotes	24
T30387	1964-1974	VB	denotes	determined
T30386	1960-1963	VB	denotes	was
T30385	1950-1959	NN	denotes	viability
T30384	1945-1949	NN	denotes	Cell
T30383	1921-1924	NN	denotes	fmk
T30382	1919-1921	CD	denotes	D.
T30381	1916-1919	IN	denotes	zVA
T30380	1911-1915	NN	denotes	with
T30379	1909-1911	CC	denotes	d
T30378	1901-1909	NN	denotes	r treate
T30377	1897-1901	IN	denotes	ot o
T30376	1890-1897	VB	denotes	tern bl
T30375	1888-1890	CC	denotes	es
T30374	1884-1888	NN	denotes	or w
T30373	1877-1884	JJ	denotes	ested f
T30372	1874-1877	IN	denotes	arv
T30371	1865-1874	VB	denotes	wn were h
T30370	1861-1865	VB	denotes	ckdo
T30369	1852-1861	NN	denotes	siRNA kno
T30368	1847-1852	NN	denotes	mTOR
T30367	1842-1846	NN	denotes	with
T30366	1838-1842	IN	denotes	lls
T30365	1833-1838	NN	denotes	29 ce
T30364	1829-1833	NN	denotes	) L9
T30363	1828-1829	-RRB-	denotes	D
T30362	1827-1828	NN	denotes	(
T30361	1825-1826	-LRB-	denotes	.
T30360	1824-1825	-RRB-	denotes	)
T30359	1818-1824	NN	denotes	PI-103
T30358	1814-1817	CC	denotes	and
T30357	1806-1813	NN	denotes	Torin-1
T30356	1804-1805	-COMMA-	denotes	,
T30355	1795-1804	NN	denotes	rapamycin
T30354	1794-1795	-LRB-	denotes	(
T30353	1789-1793	NN	denotes	mTOR
T30352	1785-1788	CC	denotes	and
T30351	1783-1784	-RRB-	denotes	)
T30350	1779-1783	CD	denotes	VIII
T30349	1774-1777	NN	denotes	inh
T30348	1770-1773	NN	denotes	Akt
T30347	1769-1770	-LRB-	denotes	(
T30346	1766-1769	NN	denotes	Akt
T30345	1763-1765	IN	denotes	of
T30344	1752-1762	NN	denotes	inhibitors
T30343	1749-1751	IN	denotes	of
T30342	1740-1748	NN	denotes	presence
T30341	1736-1739	DT	denotes	the
T30340	1733-1735	IN	denotes	in
T30339	1728-1732	NN	denotes	cell
T30338	1723-1727	NN	denotes	L929
T30337	1720-1722	IN	denotes	in
T30336	1715-1719	NN	denotes	TNFα
T30335	1712-1714	CC	denotes	or
T30334	1703-1711	NN	denotes	zVAD.fmk
T30333	1700-1702	IN	denotes	by
T30332	1692-1699	VB	denotes	induced
T30331	1688-1691	VB	denotes	was
T30330	1676-1687	NN	denotes	Necroptosis
T30329	1674-1675	-RRB-	denotes	)
T30328	1673-1674	NN	denotes	C
T30327	1672-1673	-LRB-	denotes	(
T30326	1660-1671	NN	denotes	antibodies.
T30325	1650-1659	VB	denotes	indicated
T30324	1646-1649	DT	denotes	the
T30323	1640-1645	VB	denotes	using
T30322	1631-1639	NN	denotes	blotting
T30321	1623-1630	JJ	denotes	western
T30320	1620-1622	IN	denotes	by
T30319	1611-1619	VB	denotes	followed
T30318	1609-1610	-COMMA-	denotes	,
T30317	1605-1609	NN	denotes	time
T30316	1602-1604	IN	denotes	of
T30315	1594-1601	NN	denotes	amounts
T30314	1584-1593	VB	denotes	indicated
T30313	1580-1583	DT	denotes	the
T30312	1576-1579	IN	denotes	for
T30311	1562-1575	NN	denotes	bFGF/zVAD.fmk
T30310	1559-1561	CC	denotes	or
T30309	1554-1558	NN	denotes	bFGF
T30308	1549-1553	IN	denotes	with
T30307	1541-1548	VB	denotes	treated
T30306	1536-1540	VB	denotes	were
T30305	1526-1535	NN	denotes	condition
T30304	1521-1525	JJ	denotes	free
T30303	1515-1520	NN	denotes	serum
T30302	1509-1514	IN	denotes	under
T30301	1504-1508	NN	denotes	Cell
T30300	1502-1503	-RRB-	denotes	)
T30806	5047-5051	IN	denotes	with
T30805	5041-5046	NN	denotes	cells
T30804	5036-5040	NN	denotes	L929
T30803	5034-5035	-RRB-	denotes	)
T30802	5031-5034	NN	denotes	C-F
T30801	5030-5031	-LRB-	denotes	(
T30800	5022-5029	NN	denotes	levels.
T30799	5017-5021	NN	denotes	mRNA
T30798	5012-5016	NN	denotes	TNFα
T30797	5009-5011	IN	denotes	of
T30796	5000-5008	NN	denotes	analysis
T30795	4992-4999	NN	denotes	qRT-PCR
T30794	4989-4991	IN	denotes	by
T30793	4980-4988	VB	denotes	followed
T30792	4975-4979	NN	denotes	inh.
T30791	4970-4974	CD	denotes	VIII
T30790	4965-4968	NN	denotes	inh
T30789	4961-4964	NN	denotes	Akt
T30788	4958-4960	CC	denotes	or
T30787	4956-4957	-COMMA-	denotes	,
T30786	4955-4956	-RRB-	denotes	)
T30785	4951-4955	NN	denotes	rapa
T30784	4950-4951	-LRB-	denotes	(
T30783	4940-4949	NN	denotes	rapamycin
T30782	4938-4939	-COMMA-	denotes	,
T30781	4933-4938	NN	denotes	Nec-1
T30780	4928-4932	IN	denotes	with
T30779	4920-4927	VB	denotes	treated
T30778	4914-4919	NN	denotes	cells
T30777	4911-4913	IN	denotes	in
T30776	4906-4910	NN	denotes	TNFα
T30775	4903-4905	CC	denotes	or
T30774	4894-4902	NN	denotes	zVAD.fmk
T30773	4891-4893	IN	denotes	by
T30772	4883-4890	VB	denotes	induced
T30771	4879-4882	VB	denotes	was
T30770	4867-4878	NN	denotes	Necroptosis
T30769	4865-4866	-RRB-	denotes	)
T30768	4864-4865	NN	denotes	B
T30767	4863-4864	-LRB-	denotes	(
T30766	4858-4862	NN	denotes	RNA.
T30765	4854-4857	NN	denotes	18S
T30764	4848-4853	NN	denotes	mouse
T30763	4845-4847	TO	denotes	to
T30762	4834-4844	VB	denotes	normalized
T30761	4830-4833	VB	denotes	was
T30760	4825-4829	NN	denotes	Data
T30759	4818-4823	NN	denotes	mTNFα
T30758	4815-4817	IN	denotes	of
T30757	4806-4814	NN	denotes	analysis
T30756	4798-4805	NN	denotes	qRT-PCR
T30755	4795-4797	IN	denotes	by
T30754	4786-4794	VB	denotes	followed
T30753	4784-4785	-COMMA-	denotes	,
T30752	4782-4784	NN	denotes	hr
T30751	4780-4781	CD	denotes	9
T30750	4776-4779	IN	denotes	for
T30749	4767-4775	NN	denotes	zVAD.fmk
T30748	4759-4766	IN	denotes	without
T30747	4756-4758	CC	denotes	or
T30746	4751-4755	IN	denotes	with
T30745	4746-4750	NN	denotes	PDGF
T30744	4743-4745	CC	denotes	or
T30743	4738-4742	NN	denotes	bFGF
T30742	4733-4737	IN	denotes	with
T30741	4722-4732	NN	denotes	conditions
T30740	4717-4721	JJ	denotes	free
T30739	4711-4716	NN	denotes	serum
T30738	4705-4710	IN	denotes	under
T30737	4697-4704	VB	denotes	treated
T30736	4692-4696	VB	denotes	were
T30299	1501-1502	NN	denotes	B
T30298	1500-1501	-LRB-	denotes	(
T30297	1494-1499	NN	denotes	blot.
T30296	1486-1493	JJ	denotes	western
T30295	1482-1485	IN	denotes	for
T30294	1472-1481	VB	denotes	harvested
T30293	1468-1471	CC	denotes	and
T30292	1465-1467	NN	denotes	hr
T30291	1463-1464	CD	denotes	9
T30290	1459-1462	IN	denotes	for
T30289	1454-1458	NN	denotes	TNFα
T30288	1451-1453	CC	denotes	or
T30287	1442-1450	NN	denotes	zVAD.fmk
T30286	1437-1441	IN	denotes	with
T30285	1429-1436	VB	denotes	treated
T30284	1424-1428	VB	denotes	were
T30283	1418-1423	NN	denotes	cells
T30282	1413-1417	NN	denotes	L929
T30281	1411-1412	-RRB-	denotes	)
T30280	1410-1411	NN	denotes	A
T30279	1409-1410	-LRB-	denotes	(
T30278	1396-1407	NN	denotes	necroptosis
T30277	1393-1395	IN	denotes	of
T30276	1382-1392	NN	denotes	regulation
T30275	1378-1381	DT	denotes	the
T30274	1375-1377	TO	denotes	to
T30273	1363-1374	VB	denotes	contributes
T30272	1356-1362	NN	denotes	mTORC1
T10143	5751-5760	NN	denotes	synthesis
T10142	5746-5750	NN	denotes	TNFα
T10141	5743-5745	IN	denotes	in
T10140	5734-5742	NN	denotes	increase
T10139	5712-5733	JJ	denotes	necroptosis-dependent
T10138	5704-5711	VB	denotes	mediate
T10137	5691-5703	RB	denotes	specifically
T10136	5683-5690	NN	denotes	kinases
T10135	5677-5682	DT	denotes	these
T10134	5672-5676	IN	denotes	that
T10133	5661-5671	VB	denotes	suggesting
T10132	5659-5660	-COMMA-	denotes	,
T10131	5658-5659	-RRB-	denotes	)
T10130	5655-5658	NN	denotes	S6C
T10129	5650-5654	NNP	denotes	Fig.
T10128	5648-5649	-COMMA-	denotes	,
T10127	5647-5648	NN	denotes	B
T10126	5646-5647	-COMMA-	denotes	,
T10125	5644-5646	NN	denotes	6A
T10124	5639-5643	NNP	denotes	Fig.
T10123	5638-5639	-LRB-	denotes	(
T10122	5632-5637	RB	denotes	alone
T10121	5627-5631	NN	denotes	bFGF
T10120	5622-5626	IN	denotes	with
T10119	5611-5621	VB	denotes	stimulated
T10118	5605-5610	NN	denotes	cells
T10117	5601-5604	DT	denotes	the
T10116	5598-5600	IN	denotes	in
T10115	5595-5597	CC	denotes	or
T10114	5589-5594	NN	denotes	cells
T10113	5581-5588	NN	denotes	control
T10112	5578-5580	IN	denotes	in
T10111	5573-5577	NN	denotes	mRNA
T10110	5568-5572	NN	denotes	TNFα
T10109	5565-5567	IN	denotes	of
T10108	5558-5564	NN	denotes	levels
T10107	5554-5557	DT	denotes	the
T10106	5551-5553	IN	denotes	on
T10105	5544-5550	NN	denotes	effect
T10104	5541-5543	DT	denotes	no
T10103	5537-5540	VB	denotes	had
T10102	5526-5536	NN	denotes	inhibitors
T10101	5522-5525	NN	denotes	Akt
T10100	5518-5521	CC	denotes	and
T10099	5513-5517	NN	denotes	RIP1
T10098	5511-5512	-COMMA-	denotes	,
T10097	5504-5511	RB	denotes	Notably
T10096	5501-5502	-RRB-	denotes	)
T10095	5500-5501	NN	denotes	D
T10094	5499-5500	-COMMA-	denotes	,
T10093	5498-5499	NN	denotes	C
T10092	5497-5498	-COMMA-	denotes	,
T10091	5495-5497	NN	denotes	6B
T10090	5490-5494	NN	denotes	Fig.
T10089	5489-5490	-LRB-	denotes	(
T10088	5483-5488	NN	denotes	cells
T10087	5471-5482	JJ	denotes	necroptotic
T10086	5468-5470	IN	denotes	in
T10085	5461-5467	NN	denotes	levels
T10084	5456-5460	NN	denotes	mRNA
T10083	5451-5455	NN	denotes	TNFα
T10082	5443-5450	VB	denotes	reduced
T10081	5438-5442	NN	denotes	mTOR
T10080	5434-5437	CC	denotes	and
T10079	5430-5433	NN	denotes	Akt
T10078	5427-5429	IN	denotes	of
T10077	5417-5426	NN	denotes	knockdown
T10076	5411-5416	NN	denotes	siRNA
T10075	5407-5410	CC	denotes	and
T10074	5396-5406	NN	denotes	inhibition
T10073	5381-5395	JJ	denotes	small-molecule
T10072	5376-5380	DT	denotes	both
T10071	5373-5375	IN	denotes	as
T10070	5361-5372	NN	denotes	necroptosis
T10069	5354-5360	IN	denotes	during
T10068	5349-5353	NN	denotes	mRNA
T10067	5344-5348	NN	denotes	TNFα
T10066	5341-5343	IN	denotes	of
T10065	5328-5340	NN	denotes	upregulation
T10064	5324-5327	DT	denotes	the
T10063	5321-5323	TO	denotes	to
T10062	5310-5320	VB	denotes	contribute
T10061	5303-5309	NN	denotes	mTORC1
T10060	5299-5302	CC	denotes	and
T10059	5295-5298	NN	denotes	Akt
T10058	5290-5294	CC	denotes	both
T10057	5285-5289	IN	denotes	that
T10056	5275-5284	VB	denotes	suggested
T10055	5266-5274	NN	denotes	analysis
T10054	5258-5265	JJ	denotes	Further
T10053	4540-4549	NN	denotes	synthesis
T10052	4535-4539	NN	denotes	TNFα
T10051	4525-4534	JJ	denotes	autocrine
T10050	4522-4524	IN	denotes	in
T10049	4513-4521	NN	denotes	increase
T10048	4506-4512	JJ	denotes	marked
T10047	4504-4505	DT	denotes	a
T10046	4501-4503	IN	denotes	by
T10045	4489-4500	VB	denotes	accompanied
T10044	4476-4488	RB	denotes	specifically
T10043	4473-4475	VB	denotes	is
T10042	4461-4472	NN	denotes	necroptosis
T10041	4458-4460	IN	denotes	of
T10040	4447-4457	NN	denotes	activation
T10039	4442-4446	IN	denotes	that
T10038	4428-4441	VB	denotes	demonstrating
T10037	4426-4427	-COMMA-	denotes	,
T10036	4425-4426	-RRB-	denotes	)
T10035	4423-4425	NN	denotes	6A
T10034	4418-4422	NN	denotes	Fig.
T10033	4417-4418	-LRB-	denotes	(
T9791	3001-3012	NN	denotes	translation
T9790	2993-3000	NN	denotes	protein
T9789	2989-2992	IN	denotes	for
T9788	2984-2988	NN	denotes	role
T9787	2974-2983	JJ	denotes	important
T9786	2971-2973	DT	denotes	an
T9785	2961-2970	VB	denotes	suggested
T9784	2959-2960	-RRB-	denotes	]
T9783	2957-2959	CD	denotes	10
T9782	2956-2957	-LRB-	denotes	[
T9781	2949-2955	NN	denotes	screen
T9780	2943-2948	NN	denotes	siRNA
T9779	2931-2942	JJ	denotes	genome-wide
T9778	2929-2930	DT	denotes	a
T9777	2927-2928	-COMMA-	denotes	,
T9776	2920-2927	RB	denotes	Notably
T9775	2917-2918	-RRB-	denotes	]
T9774	2915-2917	CD	denotes	32
T9773	2914-2915	-LRB-	denotes	[
T9772	2911-2913	NN	denotes	S6
T9771	2903-2910	NN	denotes	protein
T9770	2893-2902	JJ	denotes	ribosomal
T9769	2891-2892	-COMMA-	denotes	,
T9768	2879-2891	RB	denotes	subsequently
T9767	2877-2878	-COMMA-	denotes	,
T9766	2874-2877	CC	denotes	and
T9765	2867-2873	NN	denotes	kinase
T9764	2861-2866	NN	denotes	p70S6
T9763	2858-2860	IN	denotes	of
T9762	2847-2857	NN	denotes	activation
T9761	2839-2846	IN	denotes	through
T9760	2827-2838	NN	denotes	translation
T9759	2817-2826	VB	denotes	regulates
T9758	2810-2816	NN	denotes	mTORC1
T9757	2807-2808	-RRB-	denotes	)
T9756	2805-2807	NN	denotes	5D
T9755	2800-2804	NN	denotes	Fig.
T9754	2799-2800	-LRB-	denotes	(
T9753	2793-2798	NN	denotes	death
T9752	2785-2792	VB	denotes	induced
T9751	2780-2784	NN	denotes	TNFα
T9750	2776-2779	CC	denotes	and
T9749	2767-2775	NN	denotes	zVAD.fmk
T9748	2762-2766	CC	denotes	both
T9747	2757-2761	IN	denotes	from
T9746	2751-2756	NN	denotes	cells
T9745	2740-2750	VB	denotes	protecting
T9744	2737-2739	IN	denotes	by
T9743	2725-2736	NN	denotes	necroptosis
T9742	2722-2724	IN	denotes	in
T9741	2717-2721	NN	denotes	mTOR
T9740	2713-2716	IN	denotes	for
T9739	2708-2712	NN	denotes	role
T9738	2706-2707	DT	denotes	a
T9737	2695-2705	VB	denotes	indicating
T9736	2690-2694	NN	denotes	data
T9735	2680-2689	NN	denotes	inhibitor
T9734	2665-2679	JJ	denotes	small-molecule
T9733	2661-2664	DT	denotes	the
T9732	2651-2660	VB	denotes	validated
T9731	2643-2650	RB	denotes	further
T9730	2637-2642	NN	denotes	siRNA
T9729	2631-2636	VB	denotes	using
T9728	2626-2630	NN	denotes	mTOR
T9727	2623-2625	IN	denotes	of
T9726	2613-2622	NN	denotes	Knockdown
T9725	2610-2611	-RRB-	denotes	)
T9724	2608-2610	NN	denotes	5C
T9723	2603-2607	NN	denotes	Fig.
T9722	2602-2603	-LRB-	denotes	(
T9721	2590-2601	NN	denotes	necroptosis
T9720	2580-2589	VB	denotes	inhibited
T9719	2568-2579	RB	denotes	efficiently
T9718	2563-2567	RB	denotes	also
T9717	2561-2562	-RRB-	denotes	]
T9716	2559-2561	CD	denotes	31
T9715	2558-2559	-LRB-	denotes	[
T9714	2551-2557	NN	denotes	PI-103
T9713	2541-2550	NN	denotes	inhibitor
T9712	2531-2540	NN	denotes	PI3K/mTOR
T9711	2526-2530	JJ	denotes	dual
T9710	2522-2525	DT	denotes	the
T9709	2518-2521	CC	denotes	and
T9708	2516-2517	-RRB-	denotes	]
T9707	2514-2516	CD	denotes	30
T9706	2513-2514	-LRB-	denotes	[
T9705	2506-2512	NN	denotes	Torin1
T9704	2496-2505	NN	denotes	inhibitor
T9703	2489-2495	NN	denotes	kinase
T9702	2484-2488	NN	denotes	mTOR
T9701	2477-2483	JJ	denotes	direct
T9700	2473-2476	DT	denotes	the
T9699	2471-2472	-COMMA-	denotes	,
T9698	2462-2471	RB	denotes	Similarly
T9697	2459-2460	-RRB-	denotes	)
T9696	2457-2459	NN	denotes	5C
T9695	2452-2456	NN	denotes	Fig.
T9694	2451-2452	-LRB-	denotes	(
T9693	2439-2450	NN	denotes	necroptosis
T9692	2434-2438	IN	denotes	from
T9691	2428-2433	NN	denotes	cells
T9690	2418-2427	JJ	denotes	protected
T9689	2416-2417	-COMMA-	denotes	,
T9688	2415-2416	-RRB-	denotes	]
T9687	2413-2415	CD	denotes	29
T9686	2412-2413	-LRB-	denotes	[
T9685	2405-2411	NN	denotes	Raptor
T9684	2395-2404	NN	denotes	co-factor
T9683	2390-2394	NN	denotes	mTOR
T9682	2386-2389	DT	denotes	the
T9681	2383-2385	IN	denotes	of
T9680	2373-2382	NN	denotes	inhibitor
T9679	2370-2372	DT	denotes	an
T9678	2368-2369	-COMMA-	denotes	,
T9677	2359-2368	NN	denotes	rapamycin
T9676	2356-2358	IN	denotes	by
T9675	2349-2355	NN	denotes	mTORC1
T9674	2346-2348	IN	denotes	of
T9673	2335-2345	NN	denotes	inhibition
T9672	2330-2334	IN	denotes	that
T9671	2324-2329	VB	denotes	found
T9670	2321-2323	PRP	denotes	We
T9669	2308-2319	NN	denotes	necroptosis
T9668	2301-2307	IN	denotes	during
T9667	2295-2300	NN	denotes	roles
T9666	2282-2294	JJ	denotes	pro-survival
T9665	2276-2281	PRP-DOLLAR-	denotes	their
T9664	2268-2275	VB	denotes	reverse
T9663	2258-2267	NN	denotes	molecules
T9662	2253-2257	JJ	denotes	same
T9661	2247-2252	DT	denotes	these
T9660	2239-2246	IN	denotes	whether
T9659	2236-2238	VB	denotes	is
T9658	2227-2235	NN	denotes	question
T9657	2217-2226	JJ	denotes	important
T9656	2214-2216	DT	denotes	An
T9655	2211-2212	-RRB-	denotes	]
T9654	2209-2211	CD	denotes	28
T9653	2208-2209	-LRB-	denotes	[
T9652	2201-2207	NN	denotes	others
T9651	2197-2200	CC	denotes	and
T9650	2191-2196	NN	denotes	GSK-3
T9649	2189-2190	-COMMA-	denotes	,
T9648	2183-2189	NN	denotes	mTORC1
T9647	2173-2182	VB	denotes	including
T9646	2163-2172	NN	denotes	effectors
T9645	2154-2162	JJ	denotes	multiple
T9644	2151-2153	IN	denotes	of
T9643	2143-2150	NN	denotes	control
T9642	2139-2142	DT	denotes	the
T9641	2131-2138	IN	denotes	through
T9640	2121-2130	NN	denotes	apoptosis
T9639	2112-2120	VB	denotes	inhibits
T9638	2107-2111	WDT	denotes	that
T9637	2099-2106	NN	denotes	protein
T9636	2086-2098	JJ	denotes	pro-survival
T9635	2084-2085	DT	denotes	a
T9634	2081-2083	VB	denotes	be
T9633	2078-2080	TO	denotes	to
T9632	2067-2077	VB	denotes	considered
T9631	2064-2066	VB	denotes	is
T9630	2057-2063	NN	denotes	kinase
T9629	2053-2056	NN	denotes	Akt
T9628	1303-1310	NN	denotes	fashion
T9627	1293-1302	JJ	denotes	dependent
T9626	1288-1292	NN	denotes	RIP1
T9625	1286-1287	DT	denotes	a
T9624	1283-1285	IN	denotes	in
T9623	1277-1282	NN	denotes	death
T9622	1272-1276	NN	denotes	cell
T9621	1260-1271	JJ	denotes	necroptotic
T9620	1257-1259	IN	denotes	of
T9619	1251-1256	NN	denotes	onset
T9618	1247-1250	DT	denotes	the
T9617	1244-1246	IN	denotes	at
T9616	1234-1243	VB	denotes	activated
T9615	1231-1233	VB	denotes	is
T9614	1223-1230	NN	denotes	network
T9613	1213-1222	NN	denotes	signaling
T9612	1209-1212	NN	denotes	Akt
T9611	1197-1208	NN	denotes	“canonical”
T9610	1193-1196	DT	denotes	the
T9609	1190-1192	IN	denotes	of
T9608	1185-1189	NN	denotes	part
T9607	1173-1184	JJ	denotes	significant
T9606	1171-1172	DT	denotes	a
T9605	1166-1170	IN	denotes	that
T9604	1156-1165	VB	denotes	suggested
T9603	1151-1155	NN	denotes	data
T9602	1145-1150	DT	denotes	these
T9601	1143-1144	-COMMA-	denotes	,
T9600	1136-1143	RB	denotes	Overall
T9599	1133-1134	-RRB-	denotes	)
T9598	1132-1133	NN	denotes	B
T9597	1130-1131	-COMMA-	denotes	,
T9596	1127-1130	NNP	denotes	S5A
T9595	1122-1126	NNP	denotes	Fig.
T9594	1120-1121	-COMMA-	denotes	,
T9593	1118-1120	NNP	denotes	5A
T9592	1113-1117	NNP	denotes	Fig.
T9591	1112-1113	-LRB-	denotes	(
T9590	1106-1111	NN	denotes	Nec-1
T9589	1103-1105	IN	denotes	by
T9588	1093-1102	VB	denotes	abrogated
T9587	1088-1092	VB	denotes	were
T9586	1077-1087	NN	denotes	substrates
T9585	1073-1076	NN	denotes	Akt
T9584	1070-1072	IN	denotes	in
T9583	1060-1069	NN	denotes	increases
T9582	1037-1059	JJ	denotes	necroptosis-associated
T9581	1033-1036	DT	denotes	the
T9580	1027-1032	NN	denotes	cases
T9579	1023-1026	DT	denotes	all
T9578	1020-1022	IN	denotes	in
T9577	1018-1019	-COMMA-	denotes	,
T9576	1011-1018	RB	denotes	Notably
T9540	793-799	NN	denotes	pFoxO1
T9539	790-792	IN	denotes	of
T9538	785-789	NN	denotes	case
T9537	781-784	DT	denotes	the
T9536	778-780	IN	denotes	In
T9535	775-776	-RRB-	denotes	)
T9534	774-775	NN	denotes	B
T9533	772-773	-COMMA-	denotes	,
T9532	769-772	NN	denotes	S5A
T9531	767-768	-COMMA-	denotes	,
T9530	765-767	NN	denotes	5B
T9529	760-764	NNP	denotes	Fig.
T9528	759-760	-LRB-	denotes	(
T9527	743-758	NN	denotes	phosphorylation
T9526	739-742	NN	denotes	Akt
T9525	736-738	IN	denotes	in
T9524	727-735	NN	denotes	increase
T9523	723-726	DT	denotes	the
T9522	712-722	VB	denotes	paralleled
T9521	704-711	NN	denotes	changes
T9520	688-703	NN	denotes	phosphorylation
T9519	684-687	DT	denotes	the
T9518	681-683	IN	denotes	of
T9517	674-680	NN	denotes	timing
T9516	670-673	DT	denotes	The
T9515	667-668	-RRB-	denotes	)
T9514	665-667	NN	denotes	5A
T9513	660-664	NNP	denotes	Fig.
T9512	659-660	-LRB-	denotes	(
T9511	648-658	JJ	denotes	pronounced
T9510	643-647	RB	denotes	less
T9509	638-642	VB	denotes	were
T9508	630-637	NN	denotes	changes
T9507	626-629	DT	denotes	the
T9506	624-625	-COMMA-	denotes	,
T9505	623-624	-RRB-	denotes	)
T9504	621-623	NN	denotes	S6
T9503	611-620	NN	denotes	substrate
T9502	607-610	PRP-DOLLAR-	denotes	its
T9501	603-606	CC	denotes	and
T9500	596-602	NN	denotes	p70S6K
T9499	594-595	-COMMA-	denotes	,
T9498	586-594	NN	denotes	GSK-3α/β
T9497	584-585	-COMMA-	denotes	,
T9496	578-584	NN	denotes	FoxO3a
T9495	577-578	-LRB-	denotes	(
T9494	571-576	NN	denotes	cases
T9493	565-570	JJ	denotes	other
T9492	562-564	IN	denotes	In
T9491	552-560	VB	denotes	observed
T9490	548-551	VB	denotes	was
T9489	539-547	NN	denotes	increase
T9488	532-538	JJ	denotes	robust
T9487	530-531	DT	denotes	a
T9486	528-529	-COMMA-	denotes	,
T9485	527-528	-RRB-	denotes	)
T9484	523-527	NN	denotes	MDM2
T9483	521-522	-COMMA-	denotes	,
T9482	516-521	NN	denotes	FoxO4
T9481	514-515	-COMMA-	denotes	,
T9480	509-514	NN	denotes	FoxO1
T9479	508-509	-LRB-	denotes	(
T9478	502-507	NN	denotes	cases
T9477	497-501	DT	denotes	some
T9476	494-496	IN	denotes	In
T9475	491-492	-RRB-	denotes	)
T9474	489-491	NN	denotes	5A
T9473	484-488	NN	denotes	Fig.
T9472	483-484	-LRB-	denotes	(
T9471	481-482	-RRB-	denotes	)
T9470	479-481	NN	denotes	S6
T9469	477-478	-COMMA-	denotes	,
T9468	476-477	-RRB-	denotes	)
T9467	470-476	NN	denotes	p70S6K
T9466	469-470	-LRB-	denotes	(
T9465	462-468	NN	denotes	Kinase
T9464	459-461	NN	denotes	S6
T9463	451-458	NN	denotes	protein
T9462	441-450	JJ	denotes	ribosomal
T9461	437-440	NN	denotes	p70
T9460	436-437	-LRB-	denotes	(
T9459	426-435	NN	denotes	molecules
T9458	415-425	JJ	denotes	downstream
T9457	412-414	IN	denotes	as
T9456	407-411	RB	denotes	well
T9455	404-406	RB	denotes	as
T9454	402-403	-RRB-	denotes	)
T9453	401-402	-RRB-	denotes	)
T9452	397-401	NN	denotes	MDM2
T9451	396-397	-LRB-	denotes	(
T9450	394-395	CD	denotes	2
T9449	387-393	JJ	denotes	minute
T9448	380-386	JJ	denotes	double
T9447	374-379	NN	denotes	mouse
T9446	370-373	CC	denotes	and
T9445	362-369	NN	denotes	kinases
T9444	356-361	NN	denotes	GSK-3
T9443	354-355	-COMMA-	denotes	,
T9442	346-354	NN	denotes	proteins
T9441	344-345	-RRB-	denotes	)
T9440	340-344	NN	denotes	FoxO
T9439	339-340	-LRB-	denotes	(
T9438	337-338	NN	denotes	O
T9437	331-336	NN	denotes	class
T9436	327-330	NN	denotes	box
T9435	318-326	NN	denotes	Forkhead
T9434	317-318	-LRB-	denotes	(
T9433	306-316	NN	denotes	substrates
T9432	302-305	NN	denotes	Akt
T9431	296-301	VB	denotes	known
T9430	287-295	JJ	denotes	multiple
T9429	284-286	IN	denotes	of
T9428	268-283	NN	denotes	phosphorylation
T9427	264-267	DT	denotes	the
T9426	261-263	IN	denotes	in
T9425	252-260	NN	denotes	increase
T9424	249-251	DT	denotes	an
T9423	240-248	VB	denotes	observed
T9422	237-239	PRP	denotes	we
T9421	235-236	-COMMA-	denotes	,
T9420	225-235	NN	denotes	conditions
T9419	213-224	JJ	denotes	necroptotic
T9418	207-212	IN	denotes	Under
T9417	197-205	NN	denotes	activity
T9416	190-196	NN	denotes	kinase
T9415	186-189	NN	denotes	Akt
T9414	183-185	IN	denotes	in
T9413	174-182	NN	denotes	increase
T9412	171-173	DT	denotes	an
T9411	168-170	IN	denotes	in
T9410	160-167	VB	denotes	results
T9409	144-159	NN	denotes	phosphorylation
T9408	137-143	NN	denotes	Thr308
T9407	134-136	IN	denotes	in
T9406	125-133	NN	denotes	increase
T9405	102-124	JJ	denotes	necroptosis-associated
T9404	98-101	DT	denotes	the
T9403	90-97	IN	denotes	whether
T9402	79-89	VB	denotes	determined
T9401	74-78	RB	denotes	next
T9400	71-73	PRP	denotes	We
T9399	59-70	NN	denotes	Necroptosis
T9398	56-58	IN	denotes	of
T9397	45-55	NN	denotes	Regulation
T9396	41-44	DT	denotes	the
T9395	38-40	TO	denotes	to
T9394	26-37	VB	denotes	Contributes
T9393	18-25	NNP	denotes	Pathway
T9392	8-17	NNP	denotes	Signaling
T9391	4-7	NNP	denotes	Akt
T9390	0-3	DT	denotes	The
T9981	4126-4136	NN	denotes	conditions
T9980	4121-4125	JJ	denotes	free
T9979	4115-4120	NN	denotes	serum
T9978	4109-4114	IN	denotes	Under
T9977	4104-4107	NN	denotes	S6C
T9976	4099-4103	NNP	denotes	Fig.
T9975	4098-4099	-LRB-	denotes	(
T9974	4093-4097	NN	denotes	RIP1
T9973	4091-4092	DT	denotes	a
T9972	4088-4090	IN	denotes	in
T9971	4082-4087	NN	denotes	cells
T9970	4077-4081	NN	denotes	L929
T9969	4074-4076	IN	denotes	in
T9968	4062-4073	NN	denotes	necroptosis
T9967	4055-4061	IN	denotes	during
T9966	4045-4054	VB	denotes	increased
T9965	4038-4044	NN	denotes	levels
T9964	4033-4037	NN	denotes	mRNA
T9963	4028-4032	NN	denotes	TNFα
T9962	4023-4027	IN	denotes	that
T9961	4017-4022	VB	denotes	found
T9960	4014-4016	PRP	denotes	we
T9959	4012-4013	-COMMA-	denotes	,
T9958	4011-4012	-RRB-	denotes	)
T9957	4010-4011	NN	denotes	B
T9956	4008-4009	-COMMA-	denotes	,
T9955	4005-4008	NN	denotes	S6A
T9954	4000-4004	NN	denotes	Fig.
T9953	3999-4000	-LRB-	denotes	(
T9952	3991-3998	NN	denotes	protein
T9951	3986-3990	NN	denotes	TNFα
T9950	3983-3985	IN	denotes	in
T9949	3974-3982	NN	denotes	increase
T9948	3959-3973	JJ	denotes	RIP1-dependent
T9947	3957-3958	DT	denotes	a
T9946	3952-3956	IN	denotes	with
T9945	3941-3951	JJ	denotes	Consistent
T9944	3930-3939	NN	denotes	synthesis
T9943	3925-3929	NN	denotes	TNFα
T9942	3922-3924	TO	denotes	to
T9941	3911-3921	VB	denotes	contribute
T9940	3901-3910	NN	denotes	effectors
T9939	3897-3900	PRP-DOLLAR-	denotes	its
T9938	3893-3896	CC	denotes	and
T9937	3889-3892	NN	denotes	Akt
T9936	3881-3888	IN	denotes	whether
T9935	3872-3880	VB	denotes	examined
T9934	3869-3871	PRP	denotes	we
T9933	3867-3868	-COMMA-	denotes	,
T9932	3858-3867	RB	denotes	Therefore
T9931	3851-3856	NN	denotes	death
T9930	3846-3850	NN	denotes	cell
T9929	3834-3845	VB	denotes	potentiates
T9928	3828-3833	WDT	denotes	which
T9927	3826-3827	-COMMA-	denotes	,
T9926	3822-3826	NN	denotes	TNFα
T9925	3819-3821	IN	denotes	of
T9924	3809-3818	NN	denotes	synthesis
T9923	3799-3808	VB	denotes	increased
T9922	3794-3798	IN	denotes	with
T9921	3783-3793	VB	denotes	associated
T9920	3780-3782	VB	denotes	is
T9919	3774-3779	NN	denotes	cells
T9918	3769-3773	NN	denotes	L929
T9917	3766-3768	IN	denotes	in
T9916	3757-3765	NN	denotes	zVAD.fmk
T9915	3754-3756	IN	denotes	by
T9914	3742-3753	NN	denotes	necroptosis
T9913	3739-3741	IN	denotes	of
T9912	3729-3738	NN	denotes	induction
T9911	3725-3728	DT	denotes	the
T9910	3720-3724	IN	denotes	that
T9909	3711-3719	VB	denotes	reported
T9908	3702-3710	RB	denotes	recently
T9907	3697-3701	VB	denotes	have
T9906	3695-3696	-RRB-	denotes	]
T9905	3693-3695	CD	denotes	10
T9904	3692-3693	-LRB-	denotes	[
T9903	3688-3691	FW	denotes	al.
T9902	3685-3687	FW	denotes	et
T9901	3678-3684	NNP	denotes	Hitomi
T9900	3665-3676	NN	denotes	necroptosis
T9899	3652-3664	VB	denotes	accompanying
T9898	3647-3651	NN	denotes	TNFα
T9897	3644-3646	IN	denotes	of
T9896	3631-3643	NN	denotes	upregulation
T9895	3627-3630	DT	denotes	the
T9894	3619-3626	VB	denotes	control
T9893	3615-3618	NN	denotes	JNK
T9892	3611-3614	CC	denotes	and
T9891	3604-3610	NN	denotes	mTORC1
T9890	3602-3603	-COMMA-	denotes	,
T9889	3599-3602	NN	denotes	Akt
T9888	3597-3598	-COMMA-	denotes	,
T9887	3591-3597	NN	denotes	kinase
T9886	3586-3590	NN	denotes	RIP1
T9885	3573-3584	NN	denotes	necroptosis
T9884	3565-3572	VB	denotes	promote
T9883	3561-3564	MD	denotes	can
T9882	3551-3560	NN	denotes	signaling
T9881	3547-3550	NN	denotes	Akt
T9880	3544-3546	IN	denotes	of
T9879	3537-3543	NN	denotes	branch
T9878	3522-3536	JJ	denotes	anti-apoptotic
T9877	3519-3521	DT	denotes	an
T9876	3516-3518	IN	denotes	of
T9875	3507-3515	NN	denotes	activity
T9874	3503-3506	DT	denotes	the
T9873	3498-3502	IN	denotes	that
T9872	3489-3497	NN	denotes	evidence
T9871	3481-3488	VB	denotes	provide
T9870	3476-3480	NN	denotes	data
T9869	3472-3475	PRP-DOLLAR-	denotes	our
T9868	3470-3471	-COMMA-	denotes	,
T9867	3462-3470	VB	denotes	explored
T9866	3456-3461	RB	denotes	fully
T9865	3453-3455	VB	denotes	be
T9864	3450-3452	TO	denotes	to
T9863	3442-3449	VB	denotes	remains
T9862	3430-3441	NN	denotes	necroptosis
T9861	3423-3429	IN	denotes	during
T9860	3415-3422	NN	denotes	targets
T9859	3411-3414	NN	denotes	Akt
T9858	3408-3410	IN	denotes	of
T9857	3397-3407	NN	denotes	repertoire
T9856	3392-3396	JJ	denotes	full
T9855	3388-3391	DT	denotes	the
T9854	3382-3387	IN	denotes	while
T9853	3380-3381	-COMMA-	denotes	,
T9852	3373-3380	RB	denotes	Overall
T9851	3360-3371	NN	denotes	necroptosis
T9850	3357-3359	IN	denotes	in
T9849	3352-3356	NN	denotes	role
T9848	3350-3351	DT	denotes	a
T9847	3345-3349	VB	denotes	play
T9846	3341-3344	MD	denotes	may
T9845	3331-3340	NN	denotes	p70S6K/S6
T9844	3328-3330	IN	denotes	by
T9843	3320-3327	NN	denotes	control
T9842	3306-3319	JJ	denotes	translational
T9841	3301-3305	IN	denotes	that
T9840	3290-3300	VB	denotes	suggesting
T9839	3288-3289	-COMMA-	denotes	,
T9838	3287-3288	-RRB-	denotes	)
T9837	3284-3287	NN	denotes	S5E
T9836	3279-3283	NNP	denotes	Fig.
T9835	3278-3279	-LRB-	denotes	(
T9834	3273-3277	RB	denotes	well
T9833	3270-3272	RB	denotes	as
T9832	3258-3269	NN	denotes	necroptosis
T9831	3247-3257	VB	denotes	attenuated
T9830	3239-3246	NN	denotes	protein
T9829	3236-3238	NN	denotes	S6
T9828	3233-3235	IN	denotes	of
T9827	3223-3232	NN	denotes	knockdown
T9826	3217-3222	NN	denotes	siRNA
T9825	3209-3216	JJ	denotes	Partial
T9824	3206-3207	-RRB-	denotes	)
T9823	3205-3206	NN	denotes	D
T9822	3203-3204	-COMMA-	denotes	,
T9821	3200-3203	NN	denotes	S5C
T9820	3195-3199	NNP	denotes	Fig.
T9819	3194-3195	-LRB-	denotes	(
T9818	3178-3193	NN	denotes	phosphorylation
T9817	3175-3177	NN	denotes	S6
T9816	3169-3174	VB	denotes	block
T9815	3166-3168	TO	denotes	to
T9814	3157-3165	VB	denotes	required
T9813	3142-3156	NN	denotes	concentrations
T9812	3138-3141	DT	denotes	the
T9811	3135-3137	IN	denotes	at
T9810	3123-3134	NN	denotes	necroptosis
T9809	3112-3122	VB	denotes	attenuated
T9808	3110-3111	-RRB-	denotes	]
T9807	3108-3110	CD	denotes	33
T9806	3107-3108	-LRB-	denotes	[
T9805	3096-3106	NN	denotes	PF-4708671
T9804	3089-3095	NN	denotes	p70S6K
T9803	3086-3088	IN	denotes	of
T9802	3076-3085	NN	denotes	inhibitor
T9801	3067-3075	NN	denotes	molecule
T9800	3061-3066	JJ	denotes	small
T9799	3057-3060	DT	denotes	the
T9798	3052-3056	IN	denotes	that
T9797	3046-3051	VB	denotes	found
T9796	3043-3045	PRP	denotes	we
T9795	3041-3042	-COMMA-	denotes	,
T9794	3029-3041	RB	denotes	Consistently
T9793	3016-3027	NN	denotes	necroptosis
T9792	3013-3015	IN	denotes	in
T10032	4408-4416	NN	denotes	zVAD.fmk
T10031	4405-4407	IN	denotes	of
T10030	4396-4404	NN	denotes	presence
T10029	4392-4395	DT	denotes	the
T10028	4389-4391	IN	denotes	in
T10027	4379-4388	VB	denotes	increased
T10026	4371-4378	RB	denotes	further
T10025	4367-4370	RB	denotes	not
T10024	4363-4366	VB	denotes	was
T10023	4357-4362	WDT	denotes	which
T10022	4355-4356	-COMMA-	denotes	,
T10021	4351-4355	NN	denotes	mRNA
T10020	4346-4350	NN	denotes	TNFα
T10019	4343-4345	IN	denotes	of
T10018	4330-4342	NN	denotes	upregulation
T10017	4323-4329	JJ	denotes	modest
T10016	4321-4322	DT	denotes	a
T10015	4314-4320	VB	denotes	caused
T10014	4309-4313	NN	denotes	PDGF
T10013	4307-4308	-COMMA-	denotes	,
T10012	4297-4307	RB	denotes	Conversely
T10011	4294-4295	-RRB-	denotes	)
T10010	4292-4294	NN	denotes	6A
T10009	4287-4291	NNP	denotes	Fig.
T10008	4286-4287	-LRB-	denotes	(
T10007	4277-4285	NN	denotes	increase
T10006	4269-4276	JJ	denotes	further
T10005	4258-4268	JJ	denotes	pronounced
T10004	4256-4257	DT	denotes	a
T10003	4249-4255	VB	denotes	caused
T10002	4247-4248	-RRB-	denotes	)
T10001	4242-4247	RB	denotes	alone
T10000	4233-4241	NN	denotes	zVAD.fmk
T9999	4229-4232	RB	denotes	not
T9998	4225-4228	CC	denotes	but
T9997	4224-4225	-LRB-	denotes	(
T9996	4215-4223	NN	denotes	zVAD.fmk
T9995	4210-4214	IN	denotes	with
T9994	4198-4209	NN	denotes	combination
T9993	4194-4197	PRP-DOLLAR-	denotes	its
T9992	4188-4193	IN	denotes	while
T9991	4186-4187	-COMMA-	denotes	,
T9990	4182-4186	NN	denotes	mRNA
T9989	4177-4181	NN	denotes	TNFα
T9988	4174-4176	IN	denotes	of
T9987	4164-4173	NN	denotes	induction
T9986	4159-4163	DT	denotes	some
T9985	4149-4158	VB	denotes	triggered
T9984	4143-4148	RB	denotes	alone
T9983	4138-4142	NN	denotes	bFGF
T9982	4136-4137	-COMMA-	denotes	,
T9575	998-1009	NN	denotes	necroptosis
T9574	991-997	IN	denotes	during
T9573	985-990	NN	denotes	place
T9572	980-984	VB	denotes	take
T9571	974-979	NN	denotes	Thr24
T9570	971-973	TO	denotes	to
T9569	962-970	NN	denotes	addition
T9568	959-961	IN	denotes	in
T9567	952-958	NN	denotes	events
T9566	936-951	NN	denotes	phosphorylation
T9565	931-935	IN	denotes	that
T9564	920-930	VB	denotes	suggesting
T9563	918-919	-COMMA-	denotes	,
T9562	917-918	-RRB-	denotes	)
T9561	916-917	NN	denotes	B
T9560	912-915	CC	denotes	and
T9559	909-911	NN	denotes	5A
T9558	904-908	FW	denotes	Fig.
T9557	894-903	VB	denotes	comparing
T9556	889-893	FW	denotes	e.g.
T9555	888-889	-LRB-	denotes	(
T9554	878-887	NN	denotes	intensity
T9553	873-877	NN	denotes	band
T9552	870-872	IN	denotes	in
T9551	861-869	NN	denotes	increase
T9550	858-860	DT	denotes	an
T9549	853-857	IN	denotes	than
T9548	846-852	RB	denotes	rather
T9547	836-845	NN	denotes	migration
T9546	833-835	IN	denotes	in
T9545	827-832	NN	denotes	shift
T9544	825-826	DT	denotes	a
T9543	816-824	VB	denotes	observed
T9542	803-815	RB	denotes	occasionally
T9541	800-802	PRP	denotes	we
R5910	T9393	T9390	arg1Of	Pathway,The
R5911	T9393	T9391	arg1Of	Pathway,Akt
R5912	T9393	T9392	arg1Of	Pathway,Signaling
R5913	T9393	T9394	arg1Of	Pathway,Contributes
R5914	T9394	T9395	arg1Of	Contributes,to
R5915	T9397	T9395	arg2Of	Regulation,to
R5916	T9397	T9396	arg1Of	Regulation,the
R5917	T9397	T9398	arg1Of	Regulation,of
R5918	T9399	T9398	arg2Of	Necroptosis,of
R5919	T9400	T9402	arg1Of	We,determined
R5920	T9402	T9401	arg1Of	determined,next
R5921	T9406	T9404	arg1Of	increase,the
R5922	T9406	T9405	arg1Of	increase,necroptosis-associated
R5923	T9406	T9407	arg1Of	increase,in
R5924	T9406	T9410	arg1Of	increase,results
R5925	T9409	T9407	arg2Of	phosphorylation,in
R5926	T9409	T9408	arg1Of	phosphorylation,Thr308
R5927	T9410	T9402	arg2Of	results,determined
R5928	T9410	T9403	arg1Of	results,whether
R5929	T9410	T9411	arg1Of	results,in
R5930	T9413	T9411	arg2Of	increase,in
R5931	T9413	T9412	arg1Of	increase,an
R5932	T9413	T9414	arg1Of	increase,in
R5933	T9417	T9414	arg2Of	activity,in
R5934	T9417	T9415	arg1Of	activity,Akt
R5935	T9417	T9416	arg1Of	activity,kinase
R5936	T9420	T9418	arg2Of	conditions,Under
R5937	T9420	T9419	arg1Of	conditions,necroptotic
R5938	T9422	T9423	arg1Of	we,observed
R5939	T9423	T9418	arg1Of	observed,Under
R5940	T9423	T9421	arg1Of	observed,","
R5941	T9425	T9423	arg2Of	increase,observed
R5942	T9425	T9424	arg1Of	increase,an
R5943	T9425	T9426	arg1Of	increase,in
R5944	T9428	T9426	arg2Of	phosphorylation,in
R5945	T9428	T9427	arg1Of	phosphorylation,the
R5946	T9428	T9429	arg1Of	phosphorylation,of
R5947	T9433	T9430	arg1Of	substrates,multiple
R5948	T9433	T9431	arg2Of	substrates,known
R5949	T9433	T9432	arg1Of	substrates,Akt
R5950	T9433	T9434	arg1Of	substrates,(
R5951	T9433	T9457	arg1Of	substrates,as
R5952	T9440	T9439	arg2Of	FoxO,(
R5953	T9441	T9439	arg3Of	),(
R5954	T9442	T9435	arg1Of	proteins,Forkhead
R5955	T9442	T9436	arg1Of	proteins,box
R5956	T9442	T9437	arg1Of	proteins,class
R5957	T9442	T9438	arg1Of	proteins,O
R5958	T9442	T9439	arg1Of	proteins,(
R5959	T9442	T9443	arg1Of	proteins,","
R5960	T9443	T9446	arg1Of	",",and
R5961	T9445	T9443	arg2Of	kinases,","
R5962	T9445	T9444	arg1Of	kinases,GSK-3
R5963	T9446	T9434	arg2Of	and,(
R5964	T9449	T9448	arg1Of	minute,double
R5965	T9450	T9446	arg2Of	2,and
R5966	T9450	T9447	arg1Of	2,mouse
R5967	T9450	T9449	arg1Of	2,minute
R5968	T9450	T9451	arg1Of	2,(
R5969	T9452	T9451	arg2Of	MDM2,(
R5970	T9453	T9451	arg3Of	),(
R5971	T9454	T9434	arg3Of	),(
R5972	T9457	T9429	arg2Of	as,of
R5973	T9457	T9455	arg1Of	as,as
R5974	T9457	T9456	arg1Of	as,well
R5975	T9459	T9457	arg2Of	molecules,as
R5976	T9459	T9458	arg1Of	molecules,downstream
R5977	T9459	T9460	arg1Of	molecules,(
R5978	T9459	T9472	arg1Of	molecules,(
R5979	T9465	T9460	arg2Of	Kinase,(
R5980	T9465	T9461	arg1Of	Kinase,p70
R5981	T9465	T9462	arg1Of	Kinase,ribosomal
R5982	T9465	T9463	arg1Of	Kinase,protein
R5983	T9465	T9464	arg1Of	Kinase,S6
R5984	T9465	T9466	arg1Of	Kinase,(
R5985	T9465	T9469	arg1Of	Kinase,","
R5986	T9467	T9466	arg2Of	p70S6K,(
R5987	T9468	T9466	arg3Of	),(
R5988	T9470	T9469	arg2Of	S6,","
R5989	T9471	T9460	arg3Of	),(
R5990	T9474	T9472	arg2Of	5A,(
R5991	T9474	T9473	arg1Of	5A,Fig.
R5992	T9475	T9472	arg3Of	),(
R5993	T9478	T9476	arg2Of	cases,In
R5994	T9478	T9477	arg1Of	cases,some
R5995	T9478	T9479	arg1Of	cases,(
R5996	T9480	T9479	arg2Of	FoxO1,(
R5997	T9480	T9481	arg1Of	FoxO1,","
R5998	T9480	T9483	arg1Of	FoxO1,","
R5999	T9482	T9481	arg2Of	FoxO4,","
R6000	T9484	T9483	arg2Of	MDM2,","
R6001	T9485	T9479	arg3Of	),(
R6002	T9489	T9487	arg1Of	increase,a
R6003	T9489	T9488	arg1Of	increase,robust
R6004	T9489	T9490	arg1Of	increase,was
R6005	T9489	T9491	arg2Of	increase,observed
R6006	T9491	T9476	arg1Of	observed,In
R6007	T9491	T9486	arg1Of	observed,","
R6008	T9491	T9490	arg2Of	observed,was
R6009	T9494	T9492	arg2Of	cases,In
R6010	T9494	T9493	arg1Of	cases,other
R6011	T9494	T9495	arg1Of	cases,(
R6012	T9496	T9497	arg1Of	FoxO3a,","
R6013	T9497	T9499	arg1Of	",",","
R6014	T9498	T9497	arg2Of	GSK-3α/β,","
R6015	T9499	T9501	arg1Of	",",and
R6016	T9500	T9499	arg2Of	p70S6K,","
R6017	T9501	T9495	arg2Of	and,(
R6018	T9504	T9501	arg2Of	S6,and
R6019	T9504	T9502	arg1Of	S6,its
R6020	T9504	T9503	arg1Of	S6,substrate
R6021	T9505	T9495	arg3Of	),(
R6022	T9508	T9507	arg1Of	changes,the
R6023	T9508	T9509	arg1Of	changes,were
R6024	T9508	T9511	arg1Of	changes,pronounced
R6025	T9509	T9492	arg1Of	were,In
R6026	T9509	T9506	arg1Of	were,","
R6027	T9511	T9509	arg2Of	pronounced,were
R6028	T9511	T9510	arg1Of	pronounced,less
R6029	T9511	T9512	arg1Of	pronounced,(
R6030	T9514	T9512	arg2Of	5A,(
R6031	T9514	T9513	arg1Of	5A,Fig.
R6032	T9515	T9512	arg3Of	),(
R6033	T9517	T9516	arg1Of	timing,The
R6034	T9517	T9518	arg1Of	timing,of
R6035	T9517	T9522	arg1Of	timing,paralleled
R6036	T9521	T9518	arg2Of	changes,of
R6037	T9521	T9519	arg1Of	changes,the
R6038	T9521	T9520	arg1Of	changes,phosphorylation
R6039	T9522	T9528	arg1Of	paralleled,(
R6040	T9524	T9522	arg2Of	increase,paralleled
R6041	T9524	T9523	arg1Of	increase,the
R6042	T9524	T9525	arg1Of	increase,in
R6043	T9527	T9525	arg2Of	phosphorylation,in
R6044	T9527	T9526	arg1Of	phosphorylation,Akt
R6045	T9530	T9528	arg2Of	5B,(
R6046	T9530	T9529	arg1Of	5B,Fig.
R6047	T9530	T9531	arg1Of	5B,","
R6048	T9530	T9533	arg1Of	5B,","
R6049	T9532	T9531	arg2Of	S5A,","
R6050	T9534	T9533	arg2Of	B,","
R6051	T9535	T9528	arg3Of	),(
R6052	T9538	T9536	arg2Of	case,In
R6053	T9538	T9537	arg1Of	case,the
R6054	T9538	T9539	arg1Of	case,of
R6055	T9540	T9539	arg2Of	pFoxO1,of
R6056	T9541	T9543	arg1Of	we,observed
R6057	T9543	T9536	arg1Of	observed,In
R6058	T9543	T9542	arg1Of	observed,occasionally
R6059	T9543	T9563	arg1Of	observed,","
R6060	T9543	T9564	modOf	observed,suggesting
R6061	T9545	T9544	arg1Of	shift,a
R6062	T9545	T9546	arg1Of	shift,in
R6063	T9545	T9549	arg1Of	shift,than
R6064	T9547	T9546	arg2Of	migration,in
R6065	T9549	T9543	arg2Of	than,observed
R6066	T9549	T9548	arg1Of	than,rather
R6067	T9551	T9549	arg2Of	increase,than
R6068	T9551	T9550	arg1Of	increase,an
R6069	T9551	T9552	arg1Of	increase,in
R6070	T9554	T9552	arg2Of	intensity,in
R6071	T9554	T9553	arg1Of	intensity,band
R6072	T9554	T9555	arg1Of	intensity,(
R6073	T9556	T9555	arg2Of	e.g.,(
R6074	T9559	T9560	arg1Of	5A,and
R6075	T9560	T9556	arg2Of	and,e.g.
R6076	T9560	T9557	arg1Of	and,comparing
R6077	T9560	T9558	arg1Of	and,Fig.
R6078	T9561	T9560	arg2Of	B,and
R6079	T9562	T9555	arg3Of	),(
R6080	T9567	T9566	arg1Of	events,phosphorylation
R6081	T9567	T9568	arg1Of	events,in
R6082	T9567	T9572	arg1Of	events,take
R6083	T9569	T9568	arg2Of	addition,in
R6084	T9569	T9570	arg1Of	addition,to
R6085	T9571	T9570	arg2Of	Thr24,to
R6086	T9572	T9564	arg2Of	take,suggesting
R6087	T9572	T9565	arg1Of	take,that
R6088	T9572	T9574	arg1Of	take,during
R6089	T9573	T9572	arg2Of	place,take
R6090	T9575	T9574	arg2Of	necroptosis,during
R6091	T9580	T9578	arg2Of	cases,in
R6092	T9580	T9579	arg1Of	cases,all
R6093	T9583	T9581	arg1Of	increases,the
R6094	T9583	T9582	arg1Of	increases,necroptosis-associated
R6095	T9583	T9584	arg1Of	increases,in
R6096	T9583	T9587	arg1Of	increases,were
R6097	T9583	T9588	arg2Of	increases,abrogated
R6098	T9586	T9584	arg2Of	substrates,in
R6099	T9586	T9585	arg1Of	substrates,Akt
R6100	T9588	T9576	arg1Of	abrogated,Notably
R6101	T9588	T9577	arg1Of	abrogated,","
R6102	T9588	T9578	arg1Of	abrogated,in
R6103	T9588	T9587	arg2Of	abrogated,were
R6104	T9590	T9588	arg1Of	Nec-1,abrogated
R6105	T9590	T9589	arg2Of	Nec-1,by
R6106	T9590	T9591	arg1Of	Nec-1,(
R6107	T9593	T9591	arg2Of	5A,(
R6108	T9593	T9592	arg1Of	5A,Fig.
R6109	T9593	T9594	arg1Of	5A,","
R6110	T9596	T9594	arg2Of	S5A,","
R6111	T9596	T9595	arg1Of	S5A,Fig.
R6112	T9596	T9597	arg1Of	S5A,","
R6113	T9598	T9597	arg2Of	B,","
R6114	T9599	T9591	arg3Of	),(
R6115	T9603	T9602	arg1Of	data,these
R6116	T9603	T9604	arg1Of	data,suggested
R6117	T9604	T9600	arg1Of	suggested,Overall
R6118	T9604	T9601	arg1Of	suggested,","
R6119	T9608	T9606	arg1Of	part,a
R6120	T9608	T9607	arg1Of	part,significant
R6121	T9608	T9609	arg1Of	part,of
R6122	T9608	T9615	arg1Of	part,is
R6123	T9608	T9616	arg2Of	part,activated
R6124	T9614	T9609	arg2Of	network,of
R6125	T9614	T9610	arg1Of	network,the
R6126	T9614	T9611	arg1Of	network,“canonical”
R6127	T9614	T9612	arg1Of	network,Akt
R6128	T9614	T9613	arg1Of	network,signaling
R6129	T9616	T9604	arg2Of	activated,suggested
R6130	T9616	T9605	arg1Of	activated,that
R6131	T9616	T9615	arg2Of	activated,is
R6132	T9616	T9617	arg1Of	activated,at
R6133	T9616	T9624	arg1Of	activated,in
R6134	T9619	T9617	arg2Of	onset,at
R6135	T9619	T9618	arg1Of	onset,the
R6136	T9619	T9620	arg1Of	onset,of
R6137	T9623	T9620	arg2Of	death,of
R6138	T9623	T9621	arg1Of	death,necroptotic
R6139	T9623	T9622	arg1Of	death,cell
R6140	T9627	T9626	arg1Of	dependent,RIP1
R6141	T9628	T9624	arg2Of	fashion,in
R6142	T9628	T9625	arg1Of	fashion,a
R6143	T9628	T9627	arg1Of	fashion,dependent
R6144	T9630	T9629	arg1Of	kinase,Akt
R6145	T9630	T9631	arg1Of	kinase,is
R6146	T9630	T9632	arg2Of	kinase,considered
R6147	T9630	T9634	arg1Of	kinase,be
R6148	T9632	T9631	arg2Of	considered,is
R6149	T9634	T9632	arg3Of	be,considered
R6150	T9634	T9633	arg1Of	be,to
R6151	T9637	T9634	arg2Of	protein,be
R6152	T9637	T9635	arg1Of	protein,a
R6153	T9637	T9636	arg1Of	protein,pro-survival
R6154	T9637	T9638	arg1Of	protein,that
R6155	T9637	T9639	arg1Of	protein,inhibits
R6156	T9639	T9641	arg1Of	inhibits,through
R6157	T9640	T9639	arg2Of	apoptosis,inhibits
R6158	T9643	T9641	arg2Of	control,through
R6159	T9643	T9642	arg1Of	control,the
R6160	T9643	T9644	arg1Of	control,of
R6161	T9646	T9644	arg2Of	effectors,of
R6162	T9646	T9645	arg1Of	effectors,multiple
R6163	T9646	T9647	arg1Of	effectors,including
R6164	T9648	T9649	arg1Of	mTORC1,","
R6165	T9649	T9651	arg1Of	",",and
R6166	T9650	T9649	arg2Of	GSK-3,","
R6167	T9651	T9647	arg2Of	and,including
R6168	T9651	T9653	arg1Of	and,[
R6169	T9652	T9651	arg2Of	others,and
R6170	T9654	T9653	arg2Of	28,[
R6171	T9655	T9653	arg3Of	],[
R6172	T9658	T9656	arg1Of	question,An
R6173	T9658	T9657	arg1Of	question,important
R6174	T9658	T9659	arg1Of	question,is
R6175	T9663	T9661	arg1Of	molecules,these
R6176	T9663	T9662	arg1Of	molecules,same
R6177	T9663	T9664	arg1Of	molecules,reverse
R6178	T9664	T9659	arg2Of	reverse,is
R6179	T9664	T9660	arg1Of	reverse,whether
R6180	T9664	T9668	arg1Of	reverse,during
R6181	T9667	T9664	arg2Of	roles,reverse
R6182	T9667	T9665	arg1Of	roles,their
R6183	T9667	T9666	arg1Of	roles,pro-survival
R6184	T9669	T9668	arg2Of	necroptosis,during
R6185	T9670	T9671	arg1Of	We,found
R6186	T9673	T9674	arg1Of	inhibition,of
R6187	T9673	T9676	arg1Of	inhibition,by
R6188	T9673	T9689	arg1Of	inhibition,","
R6189	T9673	T9690	arg1Of	inhibition,protected
R6190	T9675	T9674	arg2Of	mTORC1,of
R6191	T9677	T9676	arg2Of	rapamycin,by
R6192	T9677	T9678	arg1Of	rapamycin,","
R6193	T9680	T9678	arg2Of	inhibitor,","
R6194	T9680	T9679	arg1Of	inhibitor,an
R6195	T9680	T9681	arg1Of	inhibitor,of
R6196	T9685	T9681	arg2Of	Raptor,of
R6197	T9685	T9682	arg1Of	Raptor,the
R6198	T9685	T9683	arg1Of	Raptor,mTOR
R6199	T9685	T9684	arg1Of	Raptor,co-factor
R6200	T9685	T9686	arg1Of	Raptor,[
R6201	T9687	T9686	arg2Of	29,[
R6202	T9688	T9686	arg3Of	],[
R6203	T9690	T9671	arg2Of	protected,found
R6204	T9690	T9672	arg1Of	protected,that
R6205	T9691	T9690	arg2Of	cells,protected
R6206	T9691	T9692	arg1Of	cells,from
R6207	T9691	T9694	arg1Of	cells,(
R6208	T9693	T9692	arg2Of	necroptosis,from
R6209	T9696	T9694	arg2Of	5C,(
R6210	T9696	T9695	arg1Of	5C,Fig.
R6211	T9697	T9694	arg3Of	),(
R6212	T9705	T9700	arg1Of	Torin1,the
R6213	T9705	T9701	arg1Of	Torin1,direct
R6214	T9705	T9702	arg1Of	Torin1,mTOR
R6215	T9705	T9703	arg1Of	Torin1,kinase
R6216	T9705	T9704	arg1Of	Torin1,inhibitor
R6217	T9705	T9706	arg1Of	Torin1,[
R6218	T9705	T9709	arg1Of	Torin1,and
R6219	T9707	T9706	arg2Of	30,[
R6220	T9708	T9706	arg3Of	],[
R6221	T9709	T9720	arg1Of	and,inhibited
R6222	T9714	T9709	arg2Of	PI-103,and
R6223	T9714	T9710	arg1Of	PI-103,the
R6224	T9714	T9711	arg1Of	PI-103,dual
R6225	T9714	T9712	arg1Of	PI-103,PI3K/mTOR
R6226	T9714	T9713	arg1Of	PI-103,inhibitor
R6227	T9714	T9715	arg1Of	PI-103,[
R6228	T9716	T9715	arg2Of	31,[
R6229	T9717	T9715	arg3Of	],[
R6230	T9720	T9698	arg1Of	inhibited,Similarly
R6231	T9720	T9699	arg1Of	inhibited,","
R6232	T9720	T9718	arg1Of	inhibited,also
R6233	T9720	T9719	arg1Of	inhibited,efficiently
R6234	T9721	T9720	arg2Of	necroptosis,inhibited
R6235	T9721	T9722	arg1Of	necroptosis,(
R6236	T9724	T9722	arg2Of	5C,(
R6237	T9724	T9723	arg1Of	5C,Fig.
R6238	T9725	T9722	arg3Of	),(
R6239	T9726	T9727	arg1Of	Knockdown,of
R6240	T9726	T9729	arg1Of	Knockdown,using
R6241	T9726	T9732	arg1Of	Knockdown,validated
R6242	T9728	T9727	arg2Of	mTOR,of
R6243	T9730	T9729	arg2Of	siRNA,using
R6244	T9732	T9731	arg1Of	validated,further
R6245	T9736	T9732	arg2Of	data,validated
R6246	T9736	T9733	arg1Of	data,the
R6247	T9736	T9734	arg1Of	data,small-molecule
R6248	T9736	T9735	arg1Of	data,inhibitor
R6249	T9736	T9737	arg1Of	data,indicating
R6250	T9736	T9745	arg1Of	data,protecting
R6251	T9736	T9752	arg1Of	data,induced
R6252	T9737	T9744	arg1Of	indicating,by
R6253	T9739	T9737	arg2Of	role,indicating
R6254	T9739	T9738	arg1Of	role,a
R6255	T9739	T9740	arg1Of	role,for
R6256	T9739	T9742	arg1Of	role,in
R6257	T9741	T9740	arg2Of	mTOR,for
R6258	T9743	T9742	arg2Of	necroptosis,in
R6259	T9745	T9744	arg2Of	protecting,by
R6260	T9746	T9745	arg2Of	cells,protecting
R6261	T9746	T9747	arg1Of	cells,from
R6262	T9749	T9750	arg1Of	zVAD.fmk,and
R6263	T9750	T9747	arg2Of	and,from
R6264	T9750	T9748	arg1Of	and,both
R6265	T9751	T9750	arg2Of	TNFα,and
R6266	T9752	T9732	arg3Of	induced,validated
R6267	T9753	T9752	arg2Of	death,induced
R6268	T9753	T9754	arg1Of	death,(
R6269	T9756	T9754	arg2Of	5D,(
R6270	T9756	T9755	arg1Of	5D,Fig.
R6271	T9757	T9754	arg3Of	),(
R6272	T9758	T9759	arg1Of	mTORC1,regulates
R6273	T9759	T9761	arg1Of	regulates,through
R6274	T9759	T9773	arg1Of	regulates,[
R6275	T9760	T9759	arg2Of	translation,regulates
R6276	T9762	T9761	arg2Of	activation,through
R6277	T9762	T9763	arg1Of	activation,of
R6278	T9762	T9768	arg1Of	activation,subsequently
R6279	T9762	T9769	arg1Of	activation,","
R6280	T9763	T9766	arg1Of	of,and
R6281	T9763	T9767	arg1Of	of,","
R6282	T9765	T9763	arg2Of	kinase,of
R6283	T9765	T9764	arg1Of	kinase,p70S6
R6284	T9768	T9767	arg2Of	subsequently,","
R6285	T9772	T9769	arg2Of	S6,","
R6286	T9772	T9770	arg1Of	S6,ribosomal
R6287	T9772	T9771	arg1Of	S6,protein
R6288	T9774	T9773	arg2Of	32,[
R6289	T9775	T9773	arg3Of	],[
R6290	T9781	T9778	arg1Of	screen,a
R6291	T9781	T9779	arg1Of	screen,genome-wide
R6292	T9781	T9780	arg1Of	screen,siRNA
R6293	T9781	T9782	arg1Of	screen,[
R6294	T9781	T9785	arg1Of	screen,suggested
R6295	T9783	T9782	arg2Of	10,[
R6296	T9784	T9782	arg3Of	],[
R6297	T9785	T9776	arg1Of	suggested,Notably
R6298	T9785	T9777	arg1Of	suggested,","
R6299	T9788	T9785	arg2Of	role,suggested
R6300	T9788	T9786	arg1Of	role,an
R6301	T9788	T9787	arg1Of	role,important
R6302	T9788	T9789	arg1Of	role,for
R6303	T9788	T9792	arg1Of	role,in
R6304	T9791	T9789	arg2Of	translation,for
R6305	T9791	T9790	arg1Of	translation,protein
R6306	T9793	T9792	arg2Of	necroptosis,in
R6307	T9796	T9797	arg1Of	we,found
R6308	T9797	T9794	arg1Of	found,Consistently
R6309	T9797	T9795	arg1Of	found,","
R6310	T9802	T9799	arg1Of	inhibitor,the
R6311	T9802	T9800	arg1Of	inhibitor,small
R6312	T9802	T9801	arg1Of	inhibitor,molecule
R6313	T9802	T9803	arg1Of	inhibitor,of
R6314	T9802	T9806	arg1Of	inhibitor,[
R6315	T9802	T9809	arg1Of	inhibitor,attenuated
R6316	T9805	T9803	arg2Of	PF-4708671,of
R6317	T9805	T9804	arg1Of	PF-4708671,p70S6K
R6318	T9807	T9806	arg2Of	33,[
R6319	T9808	T9806	arg3Of	],[
R6320	T9809	T9797	arg2Of	attenuated,found
R6321	T9809	T9798	arg1Of	attenuated,that
R6322	T9809	T9811	arg1Of	attenuated,at
R6323	T9810	T9809	arg2Of	necroptosis,attenuated
R6324	T9813	T9811	arg2Of	concentrations,at
R6325	T9813	T9812	arg1Of	concentrations,the
R6326	T9813	T9814	arg2Of	concentrations,required
R6327	T9813	T9816	arg1Of	concentrations,block
R6328	T9816	T9814	arg3Of	block,required
R6329	T9816	T9815	arg1Of	block,to
R6330	T9818	T9816	arg2Of	phosphorylation,block
R6331	T9818	T9817	arg1Of	phosphorylation,S6
R6332	T9818	T9819	arg1Of	phosphorylation,(
R6333	T9821	T9819	arg2Of	S5C,(
R6334	T9821	T9820	arg1Of	S5C,Fig.
R6335	T9821	T9822	arg1Of	S5C,","
R6336	T9823	T9822	arg2Of	D,","
R6337	T9824	T9819	arg3Of	),(
R6338	T9827	T9825	arg1Of	knockdown,Partial
R6339	T9827	T9826	arg1Of	knockdown,siRNA
R6340	T9827	T9828	arg1Of	knockdown,of
R6341	T9827	T9831	arg1Of	knockdown,attenuated
R6342	T9830	T9828	arg2Of	protein,of
R6343	T9830	T9829	arg1Of	protein,S6
R6344	T9831	T9834	arg1Of	attenuated,well
R6345	T9831	T9835	arg1Of	attenuated,(
R6346	T9831	T9839	arg1Of	attenuated,","
R6347	T9831	T9840	modOf	attenuated,suggesting
R6348	T9832	T9831	arg2Of	necroptosis,attenuated
R6349	T9834	T9833	arg1Of	well,as
R6350	T9837	T9835	arg2Of	S5E,(
R6351	T9837	T9836	arg1Of	S5E,Fig.
R6352	T9838	T9835	arg3Of	),(
R6353	T9843	T9842	arg1Of	control,translational
R6354	T9843	T9844	arg1Of	control,by
R6355	T9843	T9846	arg1Of	control,may
R6356	T9843	T9847	arg1Of	control,play
R6357	T9845	T9844	arg2Of	p70S6K/S6,by
R6358	T9847	T9840	arg2Of	play,suggesting
R6359	T9847	T9841	arg1Of	play,that
R6360	T9847	T9846	arg2Of	play,may
R6361	T9847	T9850	arg1Of	play,in
R6362	T9849	T9847	arg2Of	role,play
R6363	T9849	T9848	arg1Of	role,a
R6364	T9851	T9850	arg2Of	necroptosis,in
R6365	T9857	T9855	arg1Of	repertoire,the
R6366	T9857	T9856	arg1Of	repertoire,full
R6367	T9857	T9858	arg1Of	repertoire,of
R6368	T9857	T9861	arg1Of	repertoire,during
R6369	T9857	T9863	arg1Of	repertoire,remains
R6370	T9857	T9865	arg1Of	repertoire,be
R6371	T9857	T9867	arg2Of	repertoire,explored
R6372	T9860	T9858	arg2Of	targets,of
R6373	T9860	T9859	arg1Of	targets,Akt
R6374	T9862	T9861	arg2Of	necroptosis,during
R6375	T9863	T9854	arg2Of	remains,while
R6376	T9867	T9863	arg2Of	explored,remains
R6377	T9867	T9864	arg1Of	explored,to
R6378	T9867	T9865	arg2Of	explored,be
R6379	T9867	T9866	arg1Of	explored,fully
R6380	T9870	T9869	arg1Of	data,our
R6381	T9870	T9871	arg1Of	data,provide
R6382	T9871	T9852	arg1Of	provide,Overall
R6383	T9871	T9853	arg1Of	provide,","
R6384	T9871	T9854	arg1Of	provide,while
R6385	T9871	T9868	arg1Of	provide,","
R6386	T9872	T9871	arg2Of	evidence,provide
R6387	T9875	T9874	arg1Of	activity,the
R6388	T9875	T9876	arg1Of	activity,of
R6389	T9875	T9883	arg1Of	activity,can
R6390	T9875	T9884	arg1Of	activity,promote
R6391	T9879	T9876	arg2Of	branch,of
R6392	T9879	T9877	arg1Of	branch,an
R6393	T9879	T9878	arg1Of	branch,anti-apoptotic
R6394	T9879	T9880	arg1Of	branch,of
R6395	T9882	T9880	arg2Of	signaling,of
R6396	T9882	T9881	arg1Of	signaling,Akt
R6397	T9884	T9872	arg2Of	promote,evidence
R6398	T9884	T9873	arg1Of	promote,that
R6399	T9884	T9883	arg2Of	promote,can
R6400	T9885	T9884	arg2Of	necroptosis,promote
R6401	T9887	T9886	arg1Of	kinase,RIP1
R6402	T9887	T9888	arg1Of	kinase,","
R6403	T9888	T9890	arg1Of	",",","
R6404	T9889	T9888	arg2Of	Akt,","
R6405	T9890	T9892	arg1Of	",",and
R6406	T9891	T9890	arg2Of	mTORC1,","
R6407	T9892	T9894	arg1Of	and,control
R6408	T9893	T9892	arg2Of	JNK,and
R6409	T9896	T9894	arg2Of	upregulation,control
R6410	T9896	T9895	arg1Of	upregulation,the
R6411	T9896	T9897	arg1Of	upregulation,of
R6412	T9898	T9897	arg2Of	TNFα,of
R6413	T9898	T9899	arg1Of	TNFα,accompanying
R6414	T9900	T9899	arg2Of	necroptosis,accompanying
R6415	T9903	T9901	arg1Of	al.,Hitomi
R6416	T9903	T9902	arg1Of	al.,et
R6417	T9903	T9904	arg1Of	al.,[
R6418	T9903	T9907	arg1Of	al.,have
R6419	T9903	T9909	arg1Of	al.,reported
R6420	T9905	T9904	arg2Of	10,[
R6421	T9906	T9904	arg3Of	],[
R6422	T9909	T9907	arg2Of	reported,have
R6423	T9909	T9908	arg1Of	reported,recently
R6424	T9912	T9911	arg1Of	induction,the
R6425	T9912	T9913	arg1Of	induction,of
R6426	T9912	T9915	arg1Of	induction,by
R6427	T9912	T9917	arg1Of	induction,in
R6428	T9912	T9920	arg1Of	induction,is
R6429	T9912	T9921	arg2Of	induction,associated
R6430	T9914	T9913	arg2Of	necroptosis,of
R6431	T9916	T9915	arg2Of	zVAD.fmk,by
R6432	T9919	T9917	arg2Of	cells,in
R6433	T9919	T9918	arg1Of	cells,L929
R6434	T9921	T9909	arg2Of	associated,reported
R6435	T9921	T9910	arg1Of	associated,that
R6436	T9921	T9920	arg2Of	associated,is
R6437	T9921	T9922	arg1Of	associated,with
R6438	T9924	T9922	arg2Of	synthesis,with
R6439	T9924	T9923	arg2Of	synthesis,increased
R6440	T9924	T9925	arg1Of	synthesis,of
R6441	T9924	T9927	arg1Of	synthesis,","
R6442	T9924	T9928	arg1Of	synthesis,which
R6443	T9924	T9929	arg1Of	synthesis,potentiates
R6444	T9926	T9925	arg2Of	TNFα,of
R6445	T9931	T9929	arg2Of	death,potentiates
R6446	T9931	T9930	arg1Of	death,cell
R6447	T9934	T9935	arg1Of	we,examined
R6448	T9935	T9932	arg1Of	examined,Therefore
R6449	T9935	T9933	arg1Of	examined,","
R6450	T9937	T9938	arg1Of	Akt,and
R6451	T9938	T9941	arg1Of	and,contribute
R6452	T9940	T9938	arg2Of	effectors,and
R6453	T9940	T9939	arg1Of	effectors,its
R6454	T9941	T9935	arg2Of	contribute,examined
R6455	T9941	T9936	arg1Of	contribute,whether
R6456	T9941	T9942	arg1Of	contribute,to
R6457	T9944	T9942	arg2Of	synthesis,to
R6458	T9944	T9943	arg1Of	synthesis,TNFα
R6459	T9945	T9946	arg1Of	Consistent,with
R6460	T9949	T9946	arg2Of	increase,with
R6461	T9949	T9947	arg1Of	increase,a
R6462	T9949	T9948	arg1Of	increase,RIP1-dependent
R6463	T9949	T9950	arg1Of	increase,in
R6464	T9949	T9953	arg1Of	increase,(
R6465	T9952	T9950	arg2Of	protein,in
R6466	T9952	T9951	arg1Of	protein,TNFα
R6467	T9955	T9953	arg2Of	S6A,(
R6468	T9955	T9954	arg1Of	S6A,Fig.
R6469	T9955	T9956	arg1Of	S6A,","
R6470	T9957	T9956	arg2Of	B,","
R6471	T9958	T9953	arg3Of	),(
R6472	T9960	T9945	arg1Of	we,Consistent
R6473	T9960	T9961	arg1Of	we,found
R6474	T9961	T9945	modOf	found,Consistent
R6475	T9961	T9959	arg1Of	found,","
R6476	T9965	T9963	arg1Of	levels,TNFα
R6477	T9965	T9964	arg1Of	levels,mRNA
R6478	T9965	T9966	arg1Of	levels,increased
R6479	T9966	T9961	arg2Of	increased,found
R6480	T9966	T9962	arg1Of	increased,that
R6481	T9966	T9967	arg1Of	increased,during
R6482	T9966	T9969	arg1Of	increased,in
R6483	T9966	T9972	arg1Of	increased,in
R6484	T9968	T9967	arg2Of	necroptosis,during
R6485	T9971	T9969	arg2Of	cells,in
R6486	T9971	T9970	arg1Of	cells,L929
R6487	T9976	T9974	arg1Of	Fig.,RIP1
R6488	T9976	T9975	arg1Of	Fig.,(
R6489	T9977	T9972	arg2Of	S6C,in
R6490	T9977	T9973	arg1Of	S6C,a
R6491	T9977	T9976	arg1Of	S6C,Fig.
R6492	T9981	T9978	arg2Of	conditions,Under
R6493	T9981	T9979	arg1Of	conditions,serum
R6494	T9981	T9980	arg1Of	conditions,free
R6495	T9983	T9984	arg1Of	bFGF,alone
R6496	T9983	T9985	arg1Of	bFGF,triggered
R6497	T9985	T9978	arg1Of	triggered,Under
R6498	T9985	T9982	arg1Of	triggered,","
R6499	T9985	T9991	arg1Of	triggered,","
R6500	T9985	T9992	arg1Of	triggered,while
R6501	T9987	T9985	arg2Of	induction,triggered
R6502	T9987	T9986	arg1Of	induction,some
R6503	T9987	T9988	arg1Of	induction,of
R6504	T9990	T9988	arg2Of	mRNA,of
R6505	T9990	T9989	arg1Of	mRNA,TNFα
R6506	T9994	T9993	arg1Of	combination,its
R6507	T9994	T9995	arg1Of	combination,with
R6508	T9994	T10003	arg1Of	combination,caused
R6509	T9996	T9995	arg2Of	zVAD.fmk,with
R6510	T9996	T9997	arg1Of	zVAD.fmk,(
R6511	T9998	T9999	arg1Of	but,not
R6512	T10000	T9997	arg2Of	zVAD.fmk,(
R6513	T10000	T9998	arg1Of	zVAD.fmk,but
R6514	T10000	T10001	arg1Of	zVAD.fmk,alone
R6515	T10002	T9997	arg3Of	),(
R6516	T10003	T9992	arg2Of	caused,while
R6517	T10007	T10003	arg2Of	increase,caused
R6518	T10007	T10004	arg1Of	increase,a
R6519	T10007	T10005	arg1Of	increase,pronounced
R6520	T10007	T10006	arg1Of	increase,further
R6521	T10007	T10008	arg1Of	increase,(
R6522	T10010	T10008	arg2Of	6A,(
R6523	T10010	T10009	arg1Of	6A,Fig.
R6524	T10011	T10008	arg3Of	),(
R6525	T10014	T10015	arg1Of	PDGF,caused
R6526	T10015	T10012	arg1Of	caused,Conversely
R6527	T10015	T10013	arg1Of	caused,","
R6528	T10018	T10015	arg2Of	upregulation,caused
R6529	T10018	T10016	arg1Of	upregulation,a
R6530	T10018	T10017	arg1Of	upregulation,modest
R6531	T10018	T10019	arg1Of	upregulation,of
R6532	T10018	T10022	arg1Of	upregulation,","
R6533	T10018	T10023	arg1Of	upregulation,which
R6534	T10018	T10024	arg1Of	upregulation,was
R6535	T10018	T10027	arg2Of	upregulation,increased
R6536	T10021	T10019	arg2Of	mRNA,of
R6537	T10021	T10020	arg1Of	mRNA,TNFα
R6538	T10027	T10024	arg2Of	increased,was
R6539	T10027	T10025	arg1Of	increased,not
R6540	T10027	T10026	arg1Of	increased,further
R6541	T10027	T10028	arg1Of	increased,in
R6542	T10027	T10037	arg1Of	increased,","
R6543	T10027	T10038	modOf	increased,demonstrating
R6544	T10028	T10029	arg1Of	in,the
R6545	T10028	T10031	arg1Of	in,of
R6546	T10030	T10028	arg2Of	presence,in
R6547	T10032	T10028	arg3Of	zVAD.fmk,in
R6548	T10032	T10033	arg1Of	zVAD.fmk,(
R6549	T10035	T10033	arg2Of	6A,(
R6550	T10035	T10034	arg1Of	6A,Fig.
R6551	T10036	T10033	arg3Of	),(
R6552	T10040	T10041	arg1Of	activation,of
R6553	T10040	T10043	arg1Of	activation,is
R6554	T10040	T10045	arg2Of	activation,accompanied
R6555	T10042	T10041	arg2Of	necroptosis,of
R6556	T10045	T10038	arg2Of	accompanied,demonstrating
R6557	T10045	T10039	arg1Of	accompanied,that
R6558	T10045	T10043	arg2Of	accompanied,is
R6559	T10045	T10044	arg1Of	accompanied,specifically
R6560	T10049	T10045	arg1Of	increase,accompanied
R6561	T10049	T10046	arg2Of	increase,by
R6562	T10049	T10047	arg1Of	increase,a
R6563	T10049	T10048	arg1Of	increase,marked
R6564	T10049	T10050	arg1Of	increase,in
R6565	T10053	T10050	arg2Of	synthesis,in
R6566	T10053	T10051	arg1Of	synthesis,autocrine
R6567	T10053	T10052	arg1Of	synthesis,TNFα
R6568	T10055	T10054	arg1Of	analysis,Further
R6569	T10055	T10056	arg1Of	analysis,suggested
R6570	T10059	T10060	arg1Of	Akt,and
R6571	T10060	T10058	arg1Of	and,both
R6572	T10060	T10062	arg1Of	and,contribute
R6573	T10061	T10060	arg2Of	mTORC1,and
R6574	T10062	T10056	arg2Of	contribute,suggested
R6575	T10062	T10057	arg1Of	contribute,that
R6576	T10062	T10063	arg1Of	contribute,to
R6577	T10062	T10069	arg1Of	contribute,during
R6578	T10062	T10071	arg1Of	contribute,as
R6579	T10065	T10063	arg2Of	upregulation,to
R6580	T10065	T10064	arg1Of	upregulation,the
R6581	T10065	T10066	arg1Of	upregulation,of
R6582	T10068	T10066	arg2Of	mRNA,of
R6583	T10068	T10067	arg1Of	mRNA,TNFα
R6584	T10070	T10069	arg2Of	necroptosis,during
R6585	T10074	T10072	arg1Of	inhibition,both
R6586	T10074	T10073	arg1Of	inhibition,small-molecule
R6587	T10074	T10075	arg1Of	inhibition,and
R6588	T10075	T10082	arg1Of	and,reduced
R6589	T10077	T10075	arg2Of	knockdown,and
R6590	T10077	T10076	arg1Of	knockdown,siRNA
R6591	T10077	T10078	arg1Of	knockdown,of
R6592	T10079	T10080	arg1Of	Akt,and
R6593	T10080	T10078	arg2Of	and,of
R6594	T10081	T10080	arg2Of	mTOR,and
R6595	T10082	T10071	arg2Of	reduced,as
R6596	T10085	T10082	arg2Of	levels,reduced
R6597	T10085	T10083	arg1Of	levels,TNFα
R6598	T10085	T10084	arg1Of	levels,mRNA
R6599	T10085	T10086	arg1Of	levels,in
R6600	T10085	T10089	arg1Of	levels,(
R6601	T10088	T10086	arg2Of	cells,in
R6602	T10088	T10087	arg1Of	cells,necroptotic
R6603	T10091	T10089	arg2Of	6B,(
R6604	T10091	T10090	arg1Of	6B,Fig.
R6605	T10091	T10092	arg1Of	6B,","
R6606	T10091	T10094	arg1Of	6B,","
R6607	T10093	T10092	arg2Of	C,","
R6608	T10095	T10094	arg2Of	D,","
R6609	T10096	T10089	arg3Of	),(
R6610	T10099	T10100	arg1Of	RIP1,and
R6611	T10101	T10100	arg2Of	Akt,and
R6612	T10102	T10099	arg1Of	inhibitors,RIP1
R6613	T10102	T10101	arg1Of	inhibitors,Akt
R6614	T10102	T10103	arg1Of	inhibitors,had
R6615	T10103	T10097	arg1Of	had,Notably
R6616	T10103	T10098	arg1Of	had,","
R6617	T10103	T10106	arg1Of	had,on
R6618	T10103	T10132	arg1Of	had,","
R6619	T10103	T10133	modOf	had,suggesting
R6620	T10105	T10103	arg2Of	effect,had
R6621	T10105	T10104	arg1Of	effect,no
R6622	T10108	T10106	arg2Of	levels,on
R6623	T10108	T10107	arg1Of	levels,the
R6624	T10108	T10109	arg1Of	levels,of
R6625	T10108	T10112	arg1Of	levels,in
R6626	T10108	T10116	arg1Of	levels,in
R6627	T10108	T10123	arg1Of	levels,(
R6628	T10111	T10109	arg2Of	mRNA,of
R6629	T10111	T10110	arg1Of	mRNA,TNFα
R6630	T10112	T10115	arg1Of	in,or
R6631	T10114	T10112	arg2Of	cells,in
R6632	T10114	T10113	arg1Of	cells,control
R6633	T10116	T10115	arg2Of	in,or
R6634	T10118	T10116	arg2Of	cells,in
R6635	T10118	T10117	arg1Of	cells,the
R6636	T10118	T10119	arg2Of	cells,stimulated
R6637	T10119	T10120	arg1Of	stimulated,with
R6638	T10121	T10120	arg2Of	bFGF,with
R6639	T10121	T10122	arg1Of	bFGF,alone
R6640	T10125	T10123	arg2Of	6A,(
R6641	T10125	T10124	arg1Of	6A,Fig.
R6642	T10125	T10126	arg1Of	6A,","
R6643	T10125	T10128	arg1Of	6A,","
R6644	T10127	T10126	arg2Of	B,","
R6645	T10130	T10128	arg2Of	S6C,","
R6646	T10130	T10129	arg1Of	S6C,Fig.
R6647	T10131	T10123	arg3Of	),(
R6648	T10136	T10135	arg1Of	kinases,these
R6649	T10136	T10138	arg1Of	kinases,mediate
R6650	T10138	T10133	arg2Of	mediate,suggesting
R6651	T10138	T10134	arg1Of	mediate,that
R6652	T10138	T10137	arg1Of	mediate,specifically
R6653	T10140	T10138	arg2Of	increase,mediate
R6654	T10140	T10139	arg1Of	increase,necroptosis-dependent
R6655	T10140	T10141	arg1Of	increase,in
R6656	T10143	T10141	arg2Of	synthesis,in
R6657	T10143	T10142	arg1Of	synthesis,TNFα
R20934	T30272	T30273	arg1Of	mTORC1,contributes
R20935	T30273	T30274	arg1Of	contributes,to
R20936	T30276	T30274	arg2Of	regulation,to
R20937	T30276	T30275	arg1Of	regulation,the
R20938	T30276	T30277	arg1Of	regulation,of
R20939	T30278	T30277	arg2Of	necroptosis,of
R20940	T30280	T30279	arg2Of	A,(
R20941	T30281	T30279	arg3Of	),(
R20942	T30283	T30279	arg1Of	cells,(
R20943	T30283	T30282	arg1Of	cells,L929
R20944	T30283	T30284	arg1Of	cells,were
R20945	T30283	T30285	arg2Of	cells,treated
R20946	T30285	T30284	arg2Of	treated,were
R20947	T30285	T30286	arg1Of	treated,with
R20948	T30287	T30288	arg1Of	zVAD.fmk,or
R20949	T30288	T30286	arg2Of	or,with
R20950	T30288	T30290	arg1Of	or,for
R20951	T30289	T30288	arg2Of	TNFα,or
R20952	T30292	T30290	arg2Of	hr,for
R20953	T30292	T30291	arg1Of	hr,9
R20954	T30294	T30293	arg2Of	harvested,and
R20955	T30294	T30295	arg1Of	harvested,for
R20956	T30294	T30302	arg1Of	harvested,under
R20957	T30299	T30298	arg2Of	B,(
R20958	T30300	T30298	arg3Of	),(
R20959	T30301	T30295	arg2Of	Cell,for
R20960	T30301	T30296	arg1Of	Cell,western
R20961	T30301	T30297	arg1Of	Cell,blot.
R20962	T30301	T30298	arg1Of	Cell,(
R20963	T30305	T30302	arg2Of	condition,under
R20964	T30305	T30303	arg1Of	condition,serum
R20965	T30305	T30304	arg1Of	condition,free
R20966	T30307	T30306	arg2Of	treated,were
R20967	T30307	T30308	arg1Of	treated,with
R20968	T30307	T30318	arg1Of	treated,","
R20969	T30307	T30319	modOf	treated,followed
R20970	T30309	T30310	arg1Of	bFGF,or
R20971	T30310	T30308	arg2Of	or,with
R20972	T30310	T30312	arg1Of	or,for
R20973	T30311	T30310	arg2Of	bFGF/zVAD.fmk,or
R20974	T30315	T30312	arg2Of	amounts,for
R20975	T30315	T30313	arg1Of	amounts,the
R20976	T30315	T30314	arg2Of	amounts,indicated
R20977	T30315	T30316	arg1Of	amounts,of
R20978	T30317	T30316	arg2Of	time,of
R20979	T30322	T30319	arg1Of	blotting,followed
R20980	T30322	T30320	arg2Of	blotting,by
R20981	T30322	T30321	arg1Of	blotting,western
R20982	T30326	T30323	arg2Of	antibodies.,using
R20983	T30326	T30324	arg1Of	antibodies.,the
R20984	T30326	T30325	arg2Of	antibodies.,indicated
R20985	T30326	T30327	arg1Of	antibodies.,(
R20986	T30328	T30327	arg2Of	C,(
R20987	T30329	T30327	arg3Of	),(
R20988	T30330	T30331	arg1Of	Necroptosis,was
R20989	T30330	T30332	arg2Of	Necroptosis,induced
R20990	T30332	T30331	arg2Of	induced,was
R20991	T30334	T30335	arg1Of	zVAD.fmk,or
R20992	T30335	T30332	arg1Of	or,induced
R20993	T30335	T30333	arg2Of	or,by
R20994	T30335	T30337	arg1Of	or,in
R20995	T30335	T30340	arg1Of	or,in
R20996	T30336	T30335	arg2Of	TNFα,or
R20997	T30339	T30337	arg2Of	cell,in
R20998	T30339	T30338	arg1Of	cell,L929
R20999	T30342	T30340	arg2Of	presence,in
R21000	T30342	T30341	arg1Of	presence,the
R21001	T30342	T30343	arg1Of	presence,of
R21002	T30342	T30345	arg1Of	presence,of
R21003	T30344	T30343	arg2Of	inhibitors,of
R21004	T30346	T30345	arg2Of	Akt,of
R21005	T30349	T30347	arg2Of	inh,(
R21006	T30349	T30348	arg1Of	inh,Akt
R21007	T30350	T30351	arg1Of	VIII,)
R21008	T30350	T30352	arg1Of	VIII,and
R21009	T30352	T30370	modOf	and,ckdo
R21010	T30353	T30352	arg2Of	mTOR,and
R21011	T30353	T30354	arg1Of	mTOR,(
R21012	T30355	T30356	arg1Of	rapamycin,","
R21013	T30356	T30358	arg1Of	",",and
R21014	T30357	T30356	arg2Of	Torin-1,","
R21015	T30358	T30354	arg2Of	and,(
R21016	T30359	T30358	arg2Of	PI-103,and
R21017	T30360	T30354	arg3Of	),(
R21018	T30362	T30361	arg2Of	(,.
R21019	T30363	T30361	arg3Of	D,.
R21020	T30365	T30361	arg1Of	29 ce,.
R21021	T30365	T30364	arg1Of	29 ce,) L9
R21022	T30365	T30366	arg1Of	29 ce,lls
R21023	T30365	T30370	arg1Of	29 ce,ckdo
R21024	T30365	T30371	arg2Of	29 ce,wn were h
R21025	T30365	T30376	arg2Of	29 ce,tern bl
R21026	T30369	T30366	arg2Of	siRNA kno,lls
R21027	T30369	T30367	arg1Of	siRNA kno,with
R21028	T30369	T30368	arg1Of	siRNA kno,mTOR
R21029	T30371	T30372	arg1Of	wn were h,arv
R21030	T30371	T30375	arg1Of	wn were h,es
R21031	T30374	T30372	arg2Of	or w,arv
R21032	T30374	T30373	arg1Of	or w,ested f
R21033	T30375	T30370	arg2Of	es,ckdo
R21034	T30376	T30375	arg2Of	tern bl,es
R21035	T30376	T30377	arg1Of	tern bl,ot o
R21036	T30376	T30381	arg1Of	tern bl,zVA
R21037	T30378	T30379	arg1Of	r treate,d
R21038	T30379	T30377	arg2Of	d ,ot o
R21039	T30380	T30379	arg2Of	with,d
R21040	T30383	T30381	arg2Of	fmk,zVA
R21041	T30383	T30382	arg1Of	fmk,D.
R21042	T30385	T30384	arg1Of	viability,Cell
R21043	T30385	T30386	arg1Of	viability,was
R21044	T30385	T30387	arg2Of	viability,determined
R21045	T30387	T30386	arg2Of	determined,was
R21046	T30387	T30390	arg1Of	determined,after
R21047	T30389	T30388	arg1Of	hr,24
R21048	T30390	T30389	arg1Of	after,hr
R21049	T30391	T30390	arg2Of	activation,after
R21050	T30391	T30392	arg1Of	activation,of
R21051	T30393	T30392	arg2Of	necroptosis,of
R21052	T30396	T30394	arg2Of	graphs,In
R21053	T30396	T30395	arg1Of	graphs,all
R21054	T30398	T30399	arg1Of	average±SD,was
R21055	T30398	T30400	arg2Of	average±SD,plotted
R21056	T30400	T30394	arg1Of	plotted,In
R21057	T30400	T30397	arg1Of	plotted,","
R21058	T30400	T30399	arg2Of	plotted,was
R21211	T30720	T30721	arg1Of	Akt,and
R21212	T30721	T30730	arg1Of	and,during
R21213	T30726	T30722	arg1Of	synthesis,mTORC1
R21214	T30726	T30723	arg1Of	synthesis,control
R21215	T30726	T30724	arg1Of	synthesis,autocrine
R21216	T30726	T30725	arg1Of	synthesis,TNFα
R21217	T30726	T30727	arg1Of	synthesis,and
R21218	T30727	T30721	arg2Of	and,and
R21219	T30729	T30727	arg2Of	activation,and
R21220	T30729	T30728	arg1Of	activation,JNK
R21221	T30731	T30730	arg2Of	necroptosis,during
R21222	T30733	T30732	arg2Of	A,(
R21223	T30734	T30732	arg3Of	),(
R21224	T30735	T30732	arg1Of	Cells,(
R21225	T30735	T30736	arg1Of	Cells,were
R21226	T30735	T30737	arg2Of	Cells,treated
R21227	T30737	T30736	arg2Of	treated,were
R21228	T30737	T30738	arg1Of	treated,under
R21229	T30737	T30753	arg1Of	treated,","
R21230	T30737	T30754	modOf	treated,followed
R21231	T30741	T30738	arg2Of	conditions,under
R21232	T30741	T30739	arg1Of	conditions,serum
R21233	T30741	T30740	arg1Of	conditions,free
R21234	T30741	T30742	arg1Of	conditions,with
R21235	T30743	T30744	arg1Of	bFGF,or
R21236	T30744	T30742	arg2Of	or,with
R21237	T30744	T30746	arg1Of	or,with
R21238	T30744	T30748	arg1Of	or,without
R21239	T30745	T30744	arg2Of	PDGF,or
R21240	T30746	T30747	arg1Of	with,or
R21241	T30748	T30747	arg2Of	without,or
R21242	T30749	T30746	arg2Of	zVAD.fmk,with
R21243	T30749	T30748	arg2Of	zVAD.fmk,without
R21244	T30749	T30750	arg1Of	zVAD.fmk,for
R21245	T30752	T30750	arg2Of	hr,for
R21246	T30752	T30751	arg1Of	hr,9
R21247	T30757	T30754	arg1Of	analysis,followed
R21248	T30757	T30755	arg2Of	analysis,by
R21249	T30757	T30756	arg1Of	analysis,qRT-PCR
R21250	T30757	T30758	arg1Of	analysis,of
R21251	T30759	T30758	arg2Of	mTNFα,of
R21252	T30760	T30761	arg1Of	Data,was
R21253	T30760	T30762	arg2Of	Data,normalized
R21254	T30762	T30761	arg2Of	normalized,was
R21255	T30762	T30763	arg1Of	normalized,to
R21256	T30762	T30780	arg1Of	normalized,with
R21257	T30766	T30763	arg2Of	RNA.,to
R21258	T30766	T30764	arg1Of	RNA.,mouse
R21259	T30766	T30765	arg1Of	RNA.,18S
R21260	T30766	T30767	arg1Of	RNA.,(
R21261	T30766	T30779	arg2Of	RNA.,treated
R21262	T30768	T30767	arg2Of	B,(
R21263	T30769	T30767	arg3Of	),(
R21264	T30770	T30771	arg1Of	Necroptosis,was
R21265	T30770	T30772	arg2Of	Necroptosis,induced
R21266	T30772	T30771	arg2Of	induced,was
R21267	T30774	T30775	arg1Of	zVAD.fmk,or
R21268	T30775	T30772	arg1Of	or,induced
R21269	T30775	T30773	arg2Of	or,by
R21270	T30775	T30777	arg1Of	or,in
R21271	T30776	T30775	arg2Of	TNFα,or
R21272	T30778	T30777	arg2Of	cells,in
R21273	T30779	T30771	modOf	treated,was
R21274	T30781	T30782	arg1Of	Nec-1,","
R21275	T30782	T30788	arg1Of	",",or
R21276	T30783	T30782	arg2Of	rapamycin,","
R21277	T30783	T30784	arg1Of	rapamycin,(
R21278	T30785	T30784	arg2Of	rapa,(
R21279	T30786	T30784	arg3Of	),(
R21280	T30788	T30780	arg2Of	or,with
R21281	T30788	T30787	arg1Of	or,","
R21282	T30790	T30788	arg2Of	inh,or
R21283	T30790	T30789	arg1Of	inh,Akt
R21284	T30792	T30791	arg1Of	inh.,VIII
R21285	T30792	T30793	arg2Of	inh.,followed
R21286	T30792	T30824	arg1Of	inh.,were
R21287	T30792	T30825	arg2Of	inh.,stimulated
R21288	T30796	T30793	arg1Of	analysis,followed
R21289	T30796	T30794	arg2Of	analysis,by
R21290	T30796	T30795	arg1Of	analysis,qRT-PCR
R21291	T30796	T30797	arg1Of	analysis,of
R21292	T30802	T30801	arg2Of	C-F,(
R21293	T30803	T30801	arg3Of	),(
R21294	T30805	T30797	arg2Of	cells,of
R21295	T30805	T30798	arg1Of	cells,TNFα
R21296	T30805	T30799	arg1Of	cells,mRNA
R21297	T30805	T30800	arg1Of	cells,levels.
R21298	T30805	T30801	arg1Of	cells,(
R21299	T30805	T30804	arg1Of	cells,L929
R21300	T30805	T30806	arg1Of	cells,with
R21301	T30808	T30806	arg2Of	knockdown,with
R21302	T30808	T30807	arg1Of	knockdown,siRNA
R21303	T30808	T30809	arg1Of	knockdown,of
R21304	T30811	T30810	arg1Of	isoforms,Akt
R21305	T30811	T30812	arg1Of	isoforms,(
R21306	T30811	T30817	arg1Of	isoforms,or
R21307	T30813	T30812	arg2Of	C,(
R21308	T30813	T30814	arg1Of	C,","
R21309	T30815	T30814	arg2Of	E,","
R21310	T30816	T30812	arg3Of	),(
R21311	T30817	T30809	arg2Of	or,of
R21312	T30818	T30817	arg2Of	mTOR,or
R21313	T30818	T30819	arg1Of	mTOR,(
R21314	T30820	T30819	arg2Of	D,(
R21315	T30820	T30821	arg1Of	D,","
R21316	T30822	T30821	arg2Of	F,","
R21317	T30823	T30819	arg3Of	),(
R21318	T30825	T30824	arg2Of	stimulated,were
R21319	T30825	T30826	arg1Of	stimulated,with
R21320	T30825	T30830	arg1Of	stimulated,for
R21321	T30825	T30833	arg1Of	stimulated,","
R21322	T30825	T30834	modOf	stimulated,followed
R21323	T30827	T30828	arg1Of	zVAD.fmk,or
R21324	T30828	T30826	arg2Of	or,with
R21325	T30829	T30828	arg2Of	TNFα,or
R21326	T30832	T30830	arg2Of	hr,for
R21327	T30832	T30831	arg1Of	hr,9
R21328	T30837	T30834	arg1Of	analysis,followed
R21329	T30837	T30835	arg2Of	analysis,by
R21330	T30837	T30836	arg1Of	analysis,qRT-PCR
R21331	T30837	T30838	arg1Of	analysis,of
R21332	T30839	T30840	arg1Of	mTNFα,(
R21333	T30839	T30845	arg1Of	mTNFα,or
R21334	T30841	T30840	arg2Of	C,(
R21335	T30841	T30842	arg1Of	C,","
R21336	T30843	T30842	arg2Of	D,","
R21337	T30844	T30840	arg3Of	),(
R21338	T30845	T30838	arg2Of	or,of
R21339	T30845	T30848	arg1Of	or,(
R21340	T30847	T30845	arg2Of	blot,or
R21341	T30847	T30846	arg1Of	blot,western
R21342	T30849	T30848	arg2Of	E,(
R21343	T30849	T30850	arg1Of	E,","
R21344	T30851	T30850	arg2Of	F,","
R21345	T30852	T30848	arg3Of	),(
R21346	T30855	T30853	arg2Of	graphs,In
R21347	T30855	T30854	arg1Of	graphs,all
R21348	T30857	T30858	arg1Of	average±SD,was
R21349	T30857	T30859	arg2Of	average±SD,plotted
R21350	T30859	T30853	arg1Of	plotted,In
R21351	T30859	T30856	arg1Of	plotted,","
R21352	T30859	T30858	arg2Of	plotted,was

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T9197	5513-5517	Antecedent	denotes	RIP1
T9196	5677-5690	Anaphor	denotes	these kinases
T9195	4330-4342	Antecedent	denotes	upregulation
T9194	4357-4362	Anaphor	denotes	which
T9193	596-602	Antecedent	denotes	p70S6K
T9192	607-610	Anaphor	denotes	its
R5906	T9192	T9193	boundBy	its,p70S6K
R5907	T9194	T9195	boundBy	which,upregulation
R5908	T9196	T9197	boundBy	these kinases,RIP1

bionlp-st-ge-2016-test-proteins

Id	Subject	Object	Predicate	Lexical cue
T9239	5746-5750	Protein	denotes	TNFα
T30689	4906-4910	Protein	denotes	TNFα
T30688	4854-4857	Protein	denotes	18S
T30687	4818-4823	Protein	denotes	mTNFα
T30686	4738-4742	Protein	denotes	bFGF
T30685	4628-4632	Protein	denotes	TNFα
T9238	5627-5631	Protein	denotes	bFGF
T9237	5568-5572	Protein	denotes	TNFα
T9236	5513-5517	Protein	denotes	RIP1
T9235	5451-5455	Protein	denotes	TNFα
T9234	5344-5348	Protein	denotes	TNFα
T9233	4535-4539	Protein	denotes	TNFα
T9232	4346-4350	Protein	denotes	TNFα
T9231	4177-4181	Protein	denotes	TNFα
T9230	4138-4142	Protein	denotes	bFGF
T9229	4093-4097	Protein	denotes	RIP1
T9228	4028-4032	Protein	denotes	TNFα
T9227	3986-3990	Protein	denotes	TNFα
T9226	3959-3963	Protein	denotes	RIP1
T9225	3925-3929	Protein	denotes	TNFα
T9224	3822-3826	Protein	denotes	TNFα
T9223	3647-3651	Protein	denotes	TNFα
T9222	3586-3590	Protein	denotes	RIP1
T9221	3338-3340	Protein	denotes	S6
T9220	3331-3337	Protein	denotes	p70S6K
T9219	3236-3238	Protein	denotes	S6
T9218	3175-3177	Protein	denotes	S6
T9217	3089-3095	Protein	denotes	p70S6K
T9216	2911-2913	Protein	denotes	S6
T9215	2861-2873	Protein	denotes	p70S6 kinase
T9214	2780-2784	Protein	denotes	TNFα
T9213	2405-2411	Protein	denotes	Raptor
T9212	1288-1292	Protein	denotes	RIP1
T9211	793-799	Protein	denotes	pFoxO1
T9210	621-623	Protein	denotes	S6
T9209	596-602	Protein	denotes	p70S6K
T9208	593-594	Protein	denotes	β
T9207	586-592	Protein	denotes	GSK-3α
T9206	578-584	Protein	denotes	FoxO3a
T9205	523-527	Protein	denotes	MDM2
T9204	516-521	Protein	denotes	FoxO4
T9203	509-514	Protein	denotes	FoxO1
T9202	479-481	Protein	denotes	S6
T9201	470-476	Protein	denotes	p70S6K
T9200	437-468	Protein	denotes	p70 ribosomal protein S6 Kinase
T9199	397-401	Protein	denotes	MDM2
T9198	380-395	Protein	denotes	double minute 2
T30692	5184-5189	Protein	denotes	mTNFα
T30691	5137-5141	Protein	denotes	TNFα
T30690	5012-5016	Protein	denotes	TNFα
T30248	1928-1932	Protein	denotes	TNFα
T30247	1715-1719	Protein	denotes	TNFα
T30246	1562-1566	Protein	denotes	bFGF
T30245	1554-1558	Protein	denotes	bFGF
T30244	1454-1458	Protein	denotes	TNFα

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T30885	5093-5097	http://www.uniprot.org/uniprot/P42345	denotes	mTOR
T30884	4738-4742	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T30883	5137-5141	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T30882	5012-5016	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T30881	4906-4910	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T30880	4628-4632	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T30879	5071-5074	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T30878	4961-4964	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T30877	4595-4598	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T30876	5071-5074	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T30875	4961-4964	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T30874	4595-4598	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T30873	5071-5074	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T30872	4961-4964	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T30871	4595-4598	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T30559	1847-1851	http://www.uniprot.org/uniprot/P42345	denotes	mTOR
T30558	1789-1793	http://www.uniprot.org/uniprot/P42345	denotes	mTOR
T30557	1770-1773	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T30556	1766-1769	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T30555	1770-1773	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T30554	1766-1769	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T30553	1770-1773	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T30552	1766-1769	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T30551	1562-1566	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T30550	1554-1558	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T30549	1928-1932	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T30548	1715-1719	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T30547	1454-1458	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10314	5627-5631	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T10313	4138-4142	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T10312	5746-5750	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10311	5568-5572	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10310	5451-5455	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10309	5344-5348	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10308	4535-4539	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10307	4346-4350	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10306	4177-4181	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10305	4028-4032	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10248	186-189	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10247	4-7	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10273	5430-5433	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10272	5295-5298	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10271	3889-3892	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10270	3599-3602	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10269	3547-3550	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10268	3411-3414	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10267	2053-2056	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10266	1209-1212	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10265	1073-1076	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10264	739-742	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10263	302-305	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10262	186-189	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10261	4-7	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10260	5522-5525	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10259	5430-5433	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10258	5295-5298	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10257	3889-3892	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10256	3599-3602	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10255	3547-3550	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10254	3411-3414	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10253	2053-2056	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10252	1209-1212	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10251	1073-1076	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10250	739-742	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10249	302-305	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T10298	2717-2721	http://www.uniprot.org/uniprot/P42345	denotes	mTOR
T10297	2626-2630	http://www.uniprot.org/uniprot/P42345	denotes	mTOR
T10296	2536-2540	http://www.uniprot.org/uniprot/P42345	denotes	mTOR
T10295	2484-2488	http://www.uniprot.org/uniprot/P42345	denotes	mTOR
T10294	2390-2394	http://www.uniprot.org/uniprot/P42345	denotes	mTOR
T10293	5513-5517	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T10292	4093-4097	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T10291	3959-3963	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T10290	3586-3590	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T10289	1288-1292	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T10288	5522-5525	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10287	5430-5433	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10286	5295-5298	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10285	3889-3892	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10284	3599-3602	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10283	3547-3550	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10282	3411-3414	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10281	2053-2056	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10280	1209-1212	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10279	1073-1076	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10278	739-742	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10277	302-305	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10276	186-189	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10275	4-7	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T10274	5522-5525	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T10304	3986-3990	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10303	3925-3929	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10302	3822-3826	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10301	3647-3651	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10300	2780-2784	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T10299	5438-5442	http://www.uniprot.org/uniprot/P42345	denotes	mTOR

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T30669	4711-4716	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T30233	1515-1520	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T9084	4115-4120	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T30698	4867-4878	http://purl.obolibrary.org/obo/GO_0097528	denotes	Necroptosis
T30697	4669-4680	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T30696	4867-4878	http://purl.obolibrary.org/obo/GO_0070266	denotes	Necroptosis
T30695	4669-4680	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T30694	4647-4650	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T30693	4633-4642	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T30254	2001-2012	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T30253	1396-1407	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T30252	1987-2012	http://purl.obolibrary.org/obo/GO_0070266	denotes	activation of necroptosis
T30251	1396-1407	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T30250	1382-1407	http://purl.obolibrary.org/obo/GO_0060544	denotes	regulation of necroptosis
T30249	1382-1392	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T9312	5751-5760	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T9311	4540-4549	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T9310	3930-3939	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T9309	3809-3818	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T9308	3615-3618	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T9307	2993-3012	http://purl.obolibrary.org/obo/GO_0006412	denotes	protein translation
T9306	2827-2838	http://purl.obolibrary.org/obo/GO_0006412	denotes	translation
T9305	2531-2535	http://purl.obolibrary.org/obo/GO_0016303	denotes	PI3K
T9304	2489-2505	http://purl.obolibrary.org/obo/GO_0033673	denotes	kinase inhibitor
T9303	2121-2130	http://purl.obolibrary.org/obo/GO_0097194	denotes	apoptosis
T9302	2121-2130	http://purl.obolibrary.org/obo/GO_0006915	denotes	apoptosis
T9301	2282-2294	http://purl.obolibrary.org/obo/GO_0043066	denotes	pro-survival
T9300	2086-2098	http://purl.obolibrary.org/obo/GO_0043066	denotes	pro-survival
T9299	3851-3856	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T9298	2793-2798	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T9297	1277-1282	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T9296	3846-3856	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T9295	1272-1282	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T9294	3551-3560	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T9293	1213-1222	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T9292	2191-2194	http://purl.obolibrary.org/obo/GO_0050321	denotes	GSK
T9291	586-589	http://purl.obolibrary.org/obo/GO_0050321	denotes	GSK
T9290	356-359	http://purl.obolibrary.org/obo/GO_0050321	denotes	GSK
T9289	190-205	http://purl.obolibrary.org/obo/GO_0016301	denotes	kinase activity
T9288	3178-3193	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T9287	936-951	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T9286	743-758	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T9285	688-703	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T9284	268-283	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T9283	144-159	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T9282	5712-5723	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9281	5361-5372	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9280	4461-4472	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9279	4062-4073	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9278	3742-3753	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9277	3665-3676	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9276	3573-3584	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9275	3430-3441	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9274	3360-3371	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9273	3258-3269	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9272	3123-3134	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9271	3016-3027	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9270	2725-2736	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9269	2590-2601	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9268	2439-2450	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9267	2308-2319	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9266	1037-1048	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9265	998-1009	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9264	102-113	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T9263	59-70	http://purl.obolibrary.org/obo/GO_0097528	denotes	Necroptosis
T9262	4447-4472	http://purl.obolibrary.org/obo/GO_0070266	denotes	activation of necroptosis
T9261	3729-3753	http://purl.obolibrary.org/obo/GO_0070266	denotes	induction of necroptosis
T9260	5361-5372	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9259	4461-4472	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9258	4062-4073	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9257	3742-3753	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9256	3665-3676	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9255	3573-3584	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9254	3430-3441	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9253	3360-3371	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9252	3258-3269	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9251	3123-3134	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9250	3016-3027	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9249	2725-2736	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9248	2590-2601	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9247	2439-2450	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9246	2308-2319	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9245	1037-1048	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9244	998-1009	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9243	102-113	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T9242	59-70	http://purl.obolibrary.org/obo/GO_0070266	denotes	Necroptosis
T9241	45-70	http://purl.obolibrary.org/obo/GO_0060544	denotes	Regulation of Necroptosis
T9240	45-55	http://purl.obolibrary.org/obo/GO_0065007	denotes	Regulation

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T9321	4309-4313	http://purl.obolibrary.org/obo/GO_0005161	denotes	PDGF
T9320	3615-3618	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T9319	2531-2535	http://purl.obolibrary.org/obo/GO_0016303	denotes	PI3K
T9318	2893-2910	http://purl.obolibrary.org/obo/GO_0003735	denotes	ribosomal protein
T9317	441-458	http://purl.obolibrary.org/obo/GO_0003735	denotes	ribosomal protein
T9316	2191-2194	http://purl.obolibrary.org/obo/GO_0050321	denotes	GSK
T9315	586-589	http://purl.obolibrary.org/obo/GO_0050321	denotes	GSK
T9314	356-359	http://purl.obolibrary.org/obo/GO_0050321	denotes	GSK
T9313	190-205	http://purl.obolibrary.org/obo/GO_0016301	denotes	kinase activity
T30700	4746-4750	http://purl.obolibrary.org/obo/GO_0005161	denotes	PDGF
T30699	4647-4650	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T30255	1660-1670	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T30703	5041-5046	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T30702	4914-4919	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T30701	4603-4609	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T30260	1660-1670	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T30259	1945-1949	http://purl.obolibrary.org/obo/GO_0005623	denotes	Cell
T30258	1836-1841	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T30257	1418-1423	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T30256	1356-1362	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T9333	3774-3793	http://purl.obolibrary.org/obo/GO_0009986	denotes	cells is associated
T9332	5303-5309	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T9331	3604-3610	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T9330	2810-2816	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T9329	2349-2355	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T9328	2183-2189	http://purl.obolibrary.org/obo/GO_0031931	denotes	mTORC1
T9327	5605-5610	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9326	5589-5594	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9325	5483-5488	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9324	4082-4087	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T9323	3846-3850	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T9322	1272-1276	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T30261	1660-1670	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies

sentences

Id	Subject	Object	Predicate	Lexical cue
T30674	5219-5257	Sentence	denotes	In all graphs, average±SD was plotted.
T30673	4970-5218	Sentence	denotes	VIII inh. followed by qRT-PCR analysis of TNFα mRNA levels. (C-F) L929 cells with siRNA knockdown of Akt isoforms (C,E) or mTOR (D,F) were stimulated with zVAD.fmk or TNFα for 9 hr, followed by qRT-PCR analysis of mTNFα (C,D) or western blot (E,F).
T30672	4825-4969	Sentence	denotes	Data was normalized to mouse 18S RNA. (B) Necroptosis was induced by zVAD.fmk or TNFα in cells treated with Nec-1, rapamycin (rapa), or Akt inh.
T30671	4682-4824	Sentence	denotes	(A) Cells were treated under serum free conditions with bFGF or PDGF with or without zVAD.fmk for 9 hr, followed by qRT-PCR analysis of mTNFα.
T30670	4595-4681	Sentence	denotes	Akt and mTORC1 control autocrine TNFα synthesis and JNK activation during necroptosis.
T30238	2014-2052	Sentence	denotes	In all graphs, average±SD was plotted.
T30237	1945-2013	Sentence	denotes	Cell viability was determined 24 hr after activation of necroptosis.
T30236	1779-1944	Sentence	denotes	VIII) and mTOR (rapamycin, Torin-1 and PI-103). (D) L929 cells with mTOR siRNA knockdown were harvested for western blot or treated with zVAD.fmk or TNFα for 24 hrs.
T30235	1409-1778	Sentence	denotes	(A) L929 cells were treated with zVAD.fmk or TNFα for 9 hr and harvested for western blot. (B) Cell under serum free condition were treated with bFGF or bFGF/zVAD.fmk for the indicated amounts of time, followed by western blotting using the indicated antibodies. (C) Necroptosis was induced by zVAD.fmk or TNFα in L929 cell in the presence of inhibitors of Akt(Akt inh.
T30234	1356-1408	Sentence	denotes	mTORC1 contributes to the regulation of necroptosis.
T9111	5504-5761	Sentence	denotes	Notably, RIP1 and Akt inhibitors had no effect on the levels of TNFα mRNA in control cells or in the cells stimulated with bFGF alone (Fig. 6A,B, Fig. S6C), suggesting that these kinases specifically mediate necroptosis-dependent increase in TNFα synthesis.
T9110	5258-5503	Sentence	denotes	Further analysis suggested that both Akt and mTORC1 contribute to the upregulation of TNFα mRNA during necroptosis as both small-molecule inhibition and siRNA knockdown of Akt and mTOR reduced TNFα mRNA levels in necroptotic cells (Fig. 6B,C,D).
T9109	4297-4550	Sentence	denotes	Conversely, PDGF caused a modest upregulation of TNFα mRNA, which was not further increased in the presence of zVAD.fmk (Fig. 6A), demonstrating that activation of necroptosis is specifically accompanied by a marked increase in autocrine TNFα synthesis.
T9108	4109-4296	Sentence	denotes	Under serum free conditions, bFGF alone triggered some induction of TNFα mRNA, while its combination with zVAD.fmk (but not zVAD.fmk alone) caused a pronounced further increase (Fig. 6A).
T9107	3941-4108	Sentence	denotes	Consistent with a RIP1-dependent increase in TNFα protein (Fig. S6A, B), we found that TNFα mRNA levels increased during necroptosis in L929 cells in a RIP1 (Fig. S6C.
T9106	3858-3940	Sentence	denotes	Therefore, we examined whether Akt and its effectors contribute to TNFα synthesis.
T9105	3678-3857	Sentence	denotes	Hitomi et al. [10] have recently reported that the induction of necroptosis by zVAD.fmk in L929 cells is associated with increased synthesis of TNFα, which potentiates cell death.
T9104	3586-3677	Sentence	denotes	RIP1 kinase, Akt, mTORC1 and JNK control the upregulation of TNFα accompanying necroptosis.
T9103	3373-3585	Sentence	denotes	Overall, while the full repertoire of Akt targets during necroptosis remains to be fully explored, our data provide evidence that the activity of an anti-apoptotic branch of Akt signaling can promote necroptosis.
T9102	3209-3372	Sentence	denotes	Partial siRNA knockdown of S6 protein attenuated necroptosis as well (Fig. S5E), suggesting that translational control by p70S6K/S6 may play a role in necroptosis.
T9101	3029-3208	Sentence	denotes	Consistently, we found that the small molecule inhibitor of p70S6K PF-4708671 [33] attenuated necroptosis at the concentrations required to block S6 phosphorylation (Fig. S5C, D).
T9100	2920-3028	Sentence	denotes	Notably, a genome-wide siRNA screen [10] suggested an important role for protein translation in necroptosis.
T9099	2810-2919	Sentence	denotes	mTORC1 regulates translation through activation of p70S6 kinase and, subsequently, ribosomal protein S6 [32].
T9098	2613-2809	Sentence	denotes	Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D).
T9097	2462-2612	Sentence	denotes	Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C).
T9096	2321-2461	Sentence	denotes	We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C).
T9095	2214-2320	Sentence	denotes	An important question is whether these same molecules reverse their pro-survival roles during necroptosis.
T9094	2053-2213	Sentence	denotes	Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28].
T9093	1136-1311	Sentence	denotes	Overall, these data suggested that a significant part of the “canonical” Akt signaling network is activated at the onset of necroptotic cell death in a RIP1 dependent fashion.
T9092	1011-1135	Sentence	denotes	Notably, in all cases the necroptosis-associated increases in Akt substrates were abrogated by Nec-1 (Fig. 5A, Fig. S5A, B).
T9091	778-1010	Sentence	denotes	In the case of pFoxO1 we occasionally observed a shift in migration rather than an increase in band intensity (e.g. comparing Fig. 5A and B), suggesting that phosphorylation events in addition to Thr24 take place during necroptosis.
T9090	670-777	Sentence	denotes	The timing of the phosphorylation changes paralleled the increase in Akt phosphorylation (Fig. 5B, S5A, B).
T9089	562-669	Sentence	denotes	In other cases (FoxO3a, GSK-3α/β, p70S6K and its substrate S6), the changes were less pronounced (Fig. 5A).
T9088	494-561	Sentence	denotes	In some cases (FoxO1, FoxO4, MDM2), a robust increase was observed.
T9087	207-493	Sentence	denotes	Under necroptotic conditions, we observed an increase in the phosphorylation of multiple known Akt substrates (Forkhead box class O (FoxO) proteins, GSK-3 kinases and mouse double minute 2 (MDM2)) as well as downstream molecules (p70 ribosomal protein S6 Kinase (p70S6K), S6) (Fig. 5A).
T9086	71-206	Sentence	denotes	We next determined whether the necroptosis-associated increase in Thr308 phosphorylation results in an increase in Akt kinase activity.
T9085	0-70	Sentence	denotes	The Akt Signaling Pathway Contributes to the Regulation of Necroptosis
T126	0-70	Sentence	denotes	The Akt Signaling Pathway Contributes to the Regulation of Necroptosis
T127	71-206	Sentence	denotes	We next determined whether the necroptosis-associated increase in Thr308 phosphorylation results in an increase in Akt kinase activity.
T128	207-493	Sentence	denotes	Under necroptotic conditions, we observed an increase in the phosphorylation of multiple known Akt substrates (Forkhead box class O (FoxO) proteins, GSK-3 kinases and mouse double minute 2 (MDM2)) as well as downstream molecules (p70 ribosomal protein S6 Kinase (p70S6K), S6) (Fig. 5A).
T129	494-561	Sentence	denotes	In some cases (FoxO1, FoxO4, MDM2), a robust increase was observed.
T130	562-669	Sentence	denotes	In other cases (FoxO3a, GSK-3α/β, p70S6K and its substrate S6), the changes were less pronounced (Fig. 5A).
T131	670-777	Sentence	denotes	The timing of the phosphorylation changes paralleled the increase in Akt phosphorylation (Fig. 5B, S5A, B).
T132	778-1010	Sentence	denotes	In the case of pFoxO1 we occasionally observed a shift in migration rather than an increase in band intensity (e.g. comparing Fig. 5A and B), suggesting that phosphorylation events in addition to Thr24 take place during necroptosis.
T133	1011-1135	Sentence	denotes	Notably, in all cases the necroptosis-associated increases in Akt substrates were abrogated by Nec-1 (Fig. 5A, Fig. S5A, B).
T134	1136-1311	Sentence	denotes	Overall, these data suggested that a significant part of the “canonical” Akt signaling network is activated at the onset of necroptotic cell death in a RIP1 dependent fashion.
T135	1312-1408	Sentence	denotes	10.1371/journal.pone.0056576.g005 Figure 5 mTORC1 contributes to the regulation of necroptosis.
T136	1409-1778	Sentence	denotes	(A) L929 cells were treated with zVAD.fmk or TNFα for 9 hr and harvested for western blot. (B) Cell under serum free condition were treated with bFGF or bFGF/zVAD.fmk for the indicated amounts of time, followed by western blotting using the indicated antibodies. (C) Necroptosis was induced by zVAD.fmk or TNFα in L929 cell in the presence of inhibitors of Akt(Akt inh.
T137	1779-1944	Sentence	denotes	VIII) and mTOR (rapamycin, Torin-1 and PI-103). (D) L929 cells with mTOR siRNA knockdown were harvested for western blot or treated with zVAD.fmk or TNFα for 24 hrs.
T138	1945-2013	Sentence	denotes	Cell viability was determined 24 hr after activation of necroptosis.
T139	2014-2052	Sentence	denotes	In all graphs, average±SD was plotted.
T140	2053-2213	Sentence	denotes	Akt kinase is considered to be a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28].
T141	2214-2320	Sentence	denotes	An important question is whether these same molecules reverse their pro-survival roles during necroptosis.
T142	2321-2461	Sentence	denotes	We found that inhibition of mTORC1 by rapamycin, an inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C).
T143	2462-2612	Sentence	denotes	Similarly, the direct mTOR kinase inhibitor Torin1 [30] and the dual PI3K/mTOR inhibitor PI-103 [31] also efficiently inhibited necroptosis (Fig. 5C).
T144	2613-2809	Sentence	denotes	Knockdown of mTOR using siRNA further validated the small-molecule inhibitor data indicating a role for mTOR in necroptosis by protecting cells from both zVAD.fmk and TNFα induced death (Fig. 5D).
T145	2810-2919	Sentence	denotes	mTORC1 regulates translation through activation of p70S6 kinase and, subsequently, ribosomal protein S6 [32].
T146	2920-3028	Sentence	denotes	Notably, a genome-wide siRNA screen [10] suggested an important role for protein translation in necroptosis.
T147	3029-3208	Sentence	denotes	Consistently, we found that the small molecule inhibitor of p70S6K PF-4708671 [33] attenuated necroptosis at the concentrations required to block S6 phosphorylation (Fig. S5C, D).
T148	3209-3372	Sentence	denotes	Partial siRNA knockdown of S6 protein attenuated necroptosis as well (Fig. S5E), suggesting that translational control by p70S6K/S6 may play a role in necroptosis.
T149	3373-3585	Sentence	denotes	Overall, while the full repertoire of Akt targets during necroptosis remains to be fully explored, our data provide evidence that the activity of an anti-apoptotic branch of Akt signaling can promote necroptosis.
T150	3586-3677	Sentence	denotes	RIP1 kinase, Akt, mTORC1 and JNK control the upregulation of TNFα accompanying necroptosis.
T151	3678-3857	Sentence	denotes	Hitomi et al. [10] have recently reported that the induction of necroptosis by zVAD.fmk in L929 cells is associated with increased synthesis of TNFα, which potentiates cell death.
T152	3858-3940	Sentence	denotes	Therefore, we examined whether Akt and its effectors contribute to TNFα synthesis.
T153	3941-4108	Sentence	denotes	Consistent with a RIP1-dependent increase in TNFα protein (Fig. S6A, B), we found that TNFα mRNA levels increased during necroptosis in L929 cells in a RIP1 (Fig. S6C.
T154	4109-4296	Sentence	denotes	Under serum free conditions, bFGF alone triggered some induction of TNFα mRNA, while its combination with zVAD.fmk (but not zVAD.fmk alone) caused a pronounced further increase (Fig. 6A).
T155	4297-4550	Sentence	denotes	Conversely, PDGF caused a modest upregulation of TNFα mRNA, which was not further increased in the presence of zVAD.fmk (Fig. 6A), demonstrating that activation of necroptosis is specifically accompanied by a marked increase in autocrine TNFα synthesis.
T156	4551-4681	Sentence	denotes	10.1371/journal.pone.0056576.g006 Figure 6 Akt and mTORC1 control autocrine TNFα synthesis and JNK activation during necroptosis.
T157	4682-4824	Sentence	denotes	(A) Cells were treated under serum free conditions with bFGF or PDGF with or without zVAD.fmk for 9 hr, followed by qRT-PCR analysis of mTNFα.
T158	4825-4969	Sentence	denotes	Data was normalized to mouse 18S RNA. (B) Necroptosis was induced by zVAD.fmk or TNFα in cells treated with Nec-1, rapamycin (rapa), or Akt inh.
T159	4970-5218	Sentence	denotes	VIII inh. followed by qRT-PCR analysis of TNFα mRNA levels. (C-F) L929 cells with siRNA knockdown of Akt isoforms (C,E) or mTOR (D,F) were stimulated with zVAD.fmk or TNFα for 9 hr, followed by qRT-PCR analysis of mTNFα (C,D) or western blot (E,F).
T160	5219-5257	Sentence	denotes	In all graphs, average±SD was plotted.
T161	5258-5503	Sentence	denotes	Further analysis suggested that both Akt and mTORC1 contribute to the upregulation of TNFα mRNA during necroptosis as both small-molecule inhibition and siRNA knockdown of Akt and mTOR reduced TNFα mRNA levels in necroptotic cells (Fig. 6B,C,D).
T162	5504-5761	Sentence	denotes	Notably, RIP1 and Akt inhibitors had no effect on the levels of TNFα mRNA in control cells or in the cells stimulated with bFGF alone (Fig. 6A,B, Fig. S6C), suggesting that these kinases specifically mediate necroptosis-dependent increase in TNFα synthesis.

simple1

Id	Subject	Object	Predicate	Lexical cue
T30719	5184-5189	Protein	denotes	mTNFα
T30718	5137-5141	Protein	denotes	TNFα
T30717	5012-5016	Protein	denotes	TNFα
T30716	4906-4910	Protein	denotes	TNFα
T30715	4854-4857	Protein	denotes	18S
T30714	4818-4823	Protein	denotes	mTNFα
T30713	4738-4742	Protein	denotes	bFGF
T30712	4628-4632	Protein	denotes	TNFα
T30271	1928-1932	Protein	denotes	TNFα
T30270	1715-1719	Protein	denotes	TNFα
T30269	1562-1566	Protein	denotes	bFGF
T30268	1554-1558	Protein	denotes	bFGF
T30267	1454-1458	Protein	denotes	TNFα
T9375	5746-5750	Protein	denotes	TNFα
T9374	5627-5631	Protein	denotes	bFGF
T9373	5568-5572	Protein	denotes	TNFα
T9372	5513-5517	Protein	denotes	RIP1
T9371	5451-5455	Protein	denotes	TNFα
T9370	5344-5348	Protein	denotes	TNFα
T9369	4535-4539	Protein	denotes	TNFα
T9368	4346-4350	Protein	denotes	TNFα
T9367	4177-4181	Protein	denotes	TNFα
T9366	4138-4142	Protein	denotes	bFGF
T9365	4093-4097	Protein	denotes	RIP1
T9364	4028-4032	Protein	denotes	TNFα
T9363	3986-3990	Protein	denotes	TNFα
T9362	3959-3963	Protein	denotes	RIP1
T9361	3925-3929	Protein	denotes	TNFα
T9360	3822-3826	Protein	denotes	TNFα
T9359	3647-3651	Protein	denotes	TNFα
T9358	3586-3590	Protein	denotes	RIP1
T9357	3338-3340	Protein	denotes	S6
T9356	3331-3337	Protein	denotes	p70S6K
T9355	3236-3238	Protein	denotes	S6
T9354	3175-3177	Protein	denotes	S6
T9353	3089-3095	Protein	denotes	p70S6K
T9352	2911-2913	Protein	denotes	S6
T9351	2861-2873	Protein	denotes	p70S6 kinase
T9350	2780-2784	Protein	denotes	TNFα
T9349	2405-2411	Protein	denotes	Raptor
T9348	1288-1292	Protein	denotes	RIP1
T9347	793-799	Protein	denotes	pFoxO1
T9346	621-623	Protein	denotes	S6
T9345	596-602	Protein	denotes	p70S6K
T9344	593-594	Protein	denotes	β
T9343	586-592	Protein	denotes	GSK-3α
T9342	578-584	Protein	denotes	FoxO3a
T9341	523-527	Protein	denotes	MDM2
T9340	516-521	Protein	denotes	FoxO4
T9339	509-514	Protein	denotes	FoxO1
T9338	479-481	Protein	denotes	S6
T9337	470-476	Protein	denotes	p70S6K
T9336	437-468	Protein	denotes	p70 ribosomal protein S6 Kinase
T9335	397-401	Protein	denotes	MDM2
T9334	380-395	Protein	denotes	double minute 2

BioNLP16_DUT

Id	Subject	Object	Predicate	Lexical cue
T30870	5022-5028	Transcription	denotes	levels
T30869	4610-4617	Regulation	denotes	control
T30868	4633-4642	Gene_expression	denotes	synthesis
T30867	5184-5189	Protein	denotes	mTNFα
T30866	5137-5141	Protein	denotes	TNFα
T30865	5012-5016	Protein	denotes	TNFα
T30864	4906-4910	Protein	denotes	TNFα
T30863	4854-4857	Protein	denotes	18S
T30862	4818-4823	Protein	denotes	mTNFα
T30861	4738-4742	Protein	denotes	bFGF
T30860	4628-4632	Protein	denotes	TNFα
T30546	1928-1932	Protein	denotes	TNFα
T30545	1715-1719	Protein	denotes	TNFα
T30544	1562-1566	Protein	denotes	bFGF
T30543	1554-1558	Protein	denotes	bFGF
T30542	1454-1458	Protein	denotes	TNFα
T10238	5310-5320	Positive_regulation	denotes	contribute
T10237	4379-4388	Positive_regulation	denotes	increased
T10236	4540-4549	Gene_expression	denotes	synthesis
T10235	4330-4342	Positive_regulation	denotes	upregulation
T10234	4513-4521	Positive_regulation	denotes	increase
T10233	4164-4173	Positive_regulation	denotes	induction
T10232	4045-4054	Positive_regulation	denotes	increased
T10231	4038-4044	Transcription	denotes	levels
T10230	3974-3982	Positive_regulation	denotes	increase
T10229	3930-3939	Gene_expression	denotes	synthesis
T10228	3911-3921	Positive_regulation	denotes	contribute
T10227	3809-3818	Gene_expression	denotes	synthesis
T10226	3799-3808	Positive_regulation	denotes	increased
T10225	3619-3626	Regulation	denotes	control
T10224	3631-3643	Positive_regulation	denotes	upregulation
T10223	3223-3232	Negative_regulation	denotes	knockdown
T10222	3076-3085	Negative_regulation	denotes	inhibitor
T10221	3178-3193	Phosphorylation	denotes	phosphorylation
T10220	3169-3174	Negative_regulation	denotes	block
T10219	2847-2857	Positive_regulation	denotes	activation
T10218	2373-2382	Negative_regulation	denotes	inhibitor
T10217	861-869	Positive_regulation	denotes	increase
T10216	539-547	Positive_regulation	denotes	increase
T10215	252-260	Positive_regulation	denotes	increase
T10214	268-283	Phosphorylation	denotes	phosphorylation
T10213	5746-5750	Protein	denotes	TNFα
T10212	5627-5631	Protein	denotes	bFGF
T10211	5568-5572	Protein	denotes	TNFα
T10210	5513-5517	Protein	denotes	RIP1
T10209	5451-5455	Protein	denotes	TNFα
T10208	5344-5348	Protein	denotes	TNFα
T10207	4535-4539	Protein	denotes	TNFα
T10206	4346-4350	Protein	denotes	TNFα
T10205	4177-4181	Protein	denotes	TNFα
T10204	4138-4142	Protein	denotes	bFGF
T10203	4093-4097	Protein	denotes	RIP1
T10202	4028-4032	Protein	denotes	TNFα
T10201	3986-3990	Protein	denotes	TNFα
T10200	3959-3963	Protein	denotes	RIP1
T10199	3925-3929	Protein	denotes	TNFα
T10198	3822-3826	Protein	denotes	TNFα
T10197	3647-3651	Protein	denotes	TNFα
T10196	3586-3590	Protein	denotes	RIP1
T10195	3338-3340	Protein	denotes	S6
T10194	3331-3337	Protein	denotes	p70S6K
T10193	3236-3238	Protein	denotes	S6
T10192	3175-3177	Protein	denotes	S6
T10191	3089-3095	Protein	denotes	p70S6K
T10190	2911-2913	Protein	denotes	S6
T10189	2861-2873	Protein	denotes	p70S6 kinase
T10188	2780-2784	Protein	denotes	TNFα
T10187	2405-2411	Protein	denotes	Raptor
T10186	1288-1292	Protein	denotes	RIP1
T10185	793-799	Protein	denotes	pFoxO1
T10184	578-584	Protein	denotes	FoxO3a
T10183	621-623	Protein	denotes	S6
T10182	596-602	Protein	denotes	p70S6K
T10181	593-594	Protein	denotes	β
T10180	586-592	Protein	denotes	GSK-3α
T10179	523-527	Protein	denotes	MDM2
T10178	516-521	Protein	denotes	FoxO4
T10177	509-514	Protein	denotes	FoxO1
T10176	479-481	Protein	denotes	S6
T10175	470-476	Protein	denotes	p70S6K
T10174	437-468	Protein	denotes	p70 ribosomal protein S6 Kinase
T10173	397-401	Protein	denotes	MDM2
T10172	380-395	Protein	denotes	double minute 2
T10246	5734-5742	Positive_regulation	denotes	increase
T10245	5751-5760	Gene_expression	denotes	synthesis
T10244	5526-5536	Negative_regulation	denotes	inhibitors
T10243	5704-5711	Positive_regulation	denotes	mediate
T10242	5544-5550	Regulation	denotes	effect
T10241	5461-5467	Transcription	denotes	levels
T10240	5328-5340	Positive_regulation	denotes	upregulation
T10239	5443-5450	Negative_regulation	denotes	reduced
R6659	T10172	T10214	themeOf	double minute 2,phosphorylation
R6660	T10173	T10214	themeOf	MDM2,phosphorylation
R6661	T10174	T10214	themeOf	p70 ribosomal protein S6 Kinase,phosphorylation
R6662	T10175	T10214	themeOf	p70S6K,phosphorylation
R6663	T10176	T10214	themeOf	S6,phosphorylation
R6664	T10178	T10216	themeOf	FoxO4,increase
R6665	T10185	T10217	themeOf	pFoxO1,increase
R6666	T10187	T10218	themeOf	Raptor,inhibitor
R6667	T10189	T10219	themeOf	p70S6 kinase,activation
R6668	T10191	T10222	themeOf	p70S6K,inhibitor
R6669	T10192	T10221	themeOf	S6,phosphorylation
R6670	T10193	T10223	themeOf	S6,knockdown
R6671	T10197	T10224	themeOf	TNFα,upregulation
R6672	T10198	T10227	themeOf	TNFα,synthesis
R6673	T10199	T10229	themeOf	TNFα,synthesis
R6674	T10201	T10230	themeOf	TNFα,increase
R6675	T10202	T10231	themeOf	TNFα,levels
R6676	T10202	T10232	themeOf	TNFα,increased
R6677	T10203	T10232	themeOf	RIP1,increased
R6678	T10205	T10233	themeOf	TNFα,induction
R6679	T10206	T10235	themeOf	TNFα,upregulation
R6680	T10207	T10236	themeOf	TNFα,synthesis
R6681	T10208	T10240	themeOf	TNFα,upregulation
R6682	T10209	T10239	themeOf	TNFα,reduced
R6683	T10209	T10241	themeOf	TNFα,levels
R6684	T10210	T10244	themeOf	RIP1,inhibitors
R6685	T10211	T10242	themeOf	TNFα,effect
R6686	T10213	T10245	themeOf	TNFα,synthesis
R6687	T10214	T10215	themeOf	phosphorylation,increase
R6688	T10214	T10215	themeOf	phosphorylation,increase
R6689	T10214	T10215	themeOf	phosphorylation,increase
R6690	T10214	T10215	themeOf	phosphorylation,increase
R6691	T10214	T10215	themeOf	phosphorylation,increase
R6692	T10221	T10220	themeOf	phosphorylation,block
R6693	T10224	T10225	themeOf	upregulation,control
R6694	T10227	T10226	themeOf	synthesis,increased
R6695	T10229	T10228	themeOf	synthesis,contribute
R6696	T10235	T10237	themeOf	upregulation,increased
R6697	T10236	T10234	themeOf	synthesis,increase
R6698	T10240	T10238	themeOf	upregulation,contribute
R6699	T10245	T10246	themeOf	synthesis,increase
R6700	T10246	T10243	themeOf	increase,mediate
R21353	T30860	T30868	themeOf	TNFα,synthesis
R21354	T30865	T30870	themeOf	TNFα,levels
R21355	T30868	T30869	themeOf	synthesis,control

BioNLP16_Messiy

Id	Subject	Object	Predicate	Lexical cue
T30915	4883-4890	Positive_regulation	denotes	induced
T30914	4633-4642	Gene_expression	denotes	synthesis
T30913	4618-4627	Positive_regulation	denotes	autocrine
T30912	5184-5189	Protein	denotes	mTNFα
T30911	5137-5141	Protein	denotes	TNFα
T30910	5012-5016	Protein	denotes	TNFα
T30909	4906-4910	Protein	denotes	TNFα
T30908	4854-4857	Protein	denotes	18S
T30907	4818-4823	Protein	denotes	mTNFα
T30906	4738-4742	Protein	denotes	bFGF
T30905	4628-4632	Protein	denotes	TNFα
T30574	1928-1932	Protein	denotes	TNFα
T30573	1715-1719	Protein	denotes	TNFα
T30572	1562-1566	Protein	denotes	bFGF
T30571	1554-1558	Protein	denotes	bFGF
T30570	1454-1458	Protein	denotes	TNFα
T10530	5734-5742	Positive_regulation	denotes	increase
T10529	5526-5536	Negative_regulation	denotes	inhibitors
T10528	5544-5550	Regulation	denotes	effect
T10527	5751-5760	Gene_expression	denotes	synthesis
T10526	5328-5340	Positive_regulation	denotes	upregulation
T10525	5443-5450	Negative_regulation	denotes	reduced
T10524	5310-5320	Positive_regulation	denotes	contribute
T10523	4330-4342	Positive_regulation	denotes	upregulation
T10522	4513-4521	Positive_regulation	denotes	increase
T10521	4379-4388	Positive_regulation	denotes	increased
T10520	4540-4549	Gene_expression	denotes	synthesis
T10519	4525-4534	Positive_regulation	denotes	autocrine
T10518	4149-4158	Positive_regulation	denotes	triggered
T10517	4164-4173	Positive_regulation	denotes	induction
T10516	4045-4054	Positive_regulation	denotes	increased
T10515	3930-3939	Gene_expression	denotes	synthesis
T10489	4028-4032	Protein	denotes	TNFα
T10488	3986-3990	Protein	denotes	TNFα
T10487	3959-3963	Protein	denotes	RIP1
T10486	3925-3929	Protein	denotes	TNFα
T10485	3822-3826	Protein	denotes	TNFα
T10484	3647-3651	Protein	denotes	TNFα
T10483	3586-3590	Protein	denotes	RIP1
T10482	3338-3340	Protein	denotes	S6
T10481	3331-3337	Protein	denotes	p70S6K
T10480	3236-3238	Protein	denotes	S6
T10479	3175-3177	Protein	denotes	S6
T10478	3089-3095	Protein	denotes	p70S6K
T10477	2911-2913	Protein	denotes	S6
T10476	2861-2873	Protein	denotes	p70S6 kinase
T10475	2780-2784	Protein	denotes	TNFα
T10474	2405-2411	Protein	denotes	Raptor
T10473	1288-1292	Protein	denotes	RIP1
T10472	793-799	Protein	denotes	pFoxO1
T10471	578-584	Protein	denotes	FoxO3a
T10470	621-623	Protein	denotes	S6
T10469	596-602	Protein	denotes	p70S6K
T10468	593-594	Protein	denotes	β
T10467	586-592	Protein	denotes	GSK-3α
T10466	523-527	Protein	denotes	MDM2
T10465	516-521	Protein	denotes	FoxO4
T10464	509-514	Protein	denotes	FoxO1
T10463	479-481	Protein	denotes	S6
T10462	470-476	Protein	denotes	p70S6K
T10461	437-468	Protein	denotes	p70 ribosomal protein S6 Kinase
T10460	397-401	Protein	denotes	MDM2
T10459	380-395	Protein	denotes	double minute 2
T10490	4093-4097	Protein	denotes	RIP1
T10503	861-869	Positive_regulation	denotes	increase
T10502	252-260	Positive_regulation	denotes	increase
T10501	268-283	Phosphorylation	denotes	phosphorylation
T10500	5746-5750	Protein	denotes	TNFα
T10499	5627-5631	Protein	denotes	bFGF
T10498	5568-5572	Protein	denotes	TNFα
T10497	5513-5517	Protein	denotes	RIP1
T10496	5451-5455	Protein	denotes	TNFα
T10495	5344-5348	Protein	denotes	TNFα
T10494	4535-4539	Protein	denotes	TNFα
T10493	4346-4350	Protein	denotes	TNFα
T10492	4177-4181	Protein	denotes	TNFα
T10491	4138-4142	Protein	denotes	bFGF
T10514	3911-3921	Positive_regulation	denotes	contribute
T10513	3799-3808	Positive_regulation	denotes	increased
T10512	3809-3818	Gene_expression	denotes	synthesis
T10511	3631-3643	Positive_regulation	denotes	upregulation
T10510	3223-3232	Negative_regulation	denotes	knockdown
T10509	3178-3193	Phosphorylation	denotes	phosphorylation
T10508	3169-3174	Negative_regulation	denotes	block
T10507	3076-3085	Negative_regulation	denotes	inhibitor
T10506	2847-2857	Positive_regulation	denotes	activation
T10505	2785-2792	Positive_regulation	denotes	induced
T10504	2373-2382	Negative_regulation	denotes	inhibitor
R6777	T10459	T10501	themeOf	double minute 2,phosphorylation
R6778	T10460	T10501	themeOf	MDM2,phosphorylation
R6779	T10461	T10501	themeOf	p70 ribosomal protein S6 Kinase,phosphorylation
R6780	T10462	T10501	themeOf	p70S6K,phosphorylation
R6781	T10463	T10501	themeOf	S6,phosphorylation
R6782	T10472	T10503	themeOf	pFoxO1,increase
R6783	T10474	T10504	themeOf	Raptor,inhibitor
R6784	T10475	T10505	themeOf	TNFα,induced
R6785	T10476	T10506	themeOf	p70S6 kinase,activation
R6786	T10478	T10507	themeOf	p70S6K,inhibitor
R6787	T10479	T10509	themeOf	S6,phosphorylation
R6788	T10480	T10510	themeOf	S6,knockdown
R6789	T10484	T10511	themeOf	TNFα,upregulation
R6790	T10485	T10512	themeOf	TNFα,synthesis
R6791	T10486	T10515	themeOf	TNFα,synthesis
R6792	T10489	T10516	themeOf	TNFα,increased
R6793	T10490	T10516	themeOf	RIP1,increased
R6794	T10492	T10517	themeOf	TNFα,induction
R6795	T10493	T10523	themeOf	TNFα,upregulation
R6796	T10494	T10520	themeOf	TNFα,synthesis
R6797	T10495	T10526	themeOf	TNFα,upregulation
R6798	T10496	T10525	themeOf	TNFα,reduced
R6799	T10497	T10529	themeOf	RIP1,inhibitors
R6800	T10498	T10528	themeOf	TNFα,effect
R6801	T10500	T10527	themeOf	TNFα,synthesis
R6802	T10501	T10502	themeOf	phosphorylation,increase
R6803	T10501	T10502	themeOf	phosphorylation,increase
R6804	T10501	T10502	themeOf	phosphorylation,increase
R6805	T10501	T10502	themeOf	phosphorylation,increase
R6806	T10501	T10502	themeOf	phosphorylation,increase
R6807	T10509	T10508	themeOf	phosphorylation,block
R6808	T10512	T10513	themeOf	synthesis,increased
R6809	T10515	T10514	themeOf	synthesis,contribute
R6810	T10517	T10518	themeOf	induction,triggered
R6811	T10520	T10522	themeOf	synthesis,increase
R6812	T10520	T10519	themeOf	synthesis,autocrine
R6813	T10523	T10521	themeOf	upregulation,increased
R6814	T10526	T10524	themeOf	upregulation,contribute
R6815	T10527	T10530	themeOf	synthesis,increase
R21359	T30905	T30914	themeOf	TNFα,synthesis
R21360	T30909	T30915	themeOf	TNFα,induced
R21361	T30914	T30913	themeOf	synthesis,autocrine

DLUT931

Id	Subject	Object	Predicate	Lexical cue
T10397	5712-5733	Regulation	denotes	necroptosis-dependent
T10396	5704-5711	Positive_regulation	denotes	mediate
T10395	5734-5742	Positive_regulation	denotes	increase
T10394	5544-5550	Regulation	denotes	effect
T10393	5751-5760	Gene_expression	denotes	synthesis
T10392	5611-5621	Positive_regulation	denotes	stimulated
T10353	5513-5517	Protein	denotes	RIP1
T10352	5451-5455	Protein	denotes	TNFα
T10351	5344-5348	Protein	denotes	TNFα
T10350	4535-4539	Protein	denotes	TNFα
T10349	4346-4350	Protein	denotes	TNFα
T10348	4177-4181	Protein	denotes	TNFα
T10347	4138-4142	Protein	denotes	bFGF
T10346	4093-4097	Protein	denotes	RIP1
T10345	4028-4032	Protein	denotes	TNFα
T10344	3986-3990	Protein	denotes	TNFα
T10343	3959-3963	Protein	denotes	RIP1
T10342	3925-3929	Protein	denotes	TNFα
T10341	3822-3826	Protein	denotes	TNFα
T10340	3647-3651	Protein	denotes	TNFα
T10339	3586-3590	Protein	denotes	RIP1
T10338	3338-3340	Protein	denotes	S6
T10337	3331-3337	Protein	denotes	p70S6K
T10336	3236-3238	Protein	denotes	S6
T10335	3175-3177	Protein	denotes	S6
T10334	3089-3095	Protein	denotes	p70S6K
T10333	2911-2913	Protein	denotes	S6
T10332	2861-2873	Protein	denotes	p70S6 kinase
T10331	2780-2784	Protein	denotes	TNFα
T10330	2405-2411	Protein	denotes	Raptor
T10329	1288-1292	Protein	denotes	RIP1
T10328	793-799	Protein	denotes	pFoxO1
T10327	578-584	Protein	denotes	FoxO3a
T10326	621-623	Protein	denotes	S6
T10325	596-602	Protein	denotes	p70S6K
T10324	593-594	Protein	denotes	β
T10323	586-592	Protein	denotes	GSK-3α
T10322	523-527	Protein	denotes	MDM2
T10321	516-521	Protein	denotes	FoxO4
T10320	509-514	Protein	denotes	FoxO1
T10319	479-481	Protein	denotes	S6
T10318	470-476	Protein	denotes	p70S6K
T10317	437-468	Protein	denotes	p70 ribosomal protein S6 Kinase
T10316	397-401	Protein	denotes	MDM2
T10315	380-395	Protein	denotes	double minute 2
T10358	252-260	Positive_regulation	denotes	increase
T10357	268-283	Phosphorylation	denotes	phosphorylation
T10356	5746-5750	Protein	denotes	TNFα
T10391	5573-5577	Transcription	denotes	mRNA
T10390	5526-5536	Negative_regulation	denotes	inhibitors
T10389	5310-5320	Positive_regulation	denotes	contribute
T10388	5461-5467	Transcription	denotes	levels
T10387	5328-5340	Positive_regulation	denotes	upregulation
T10386	4525-4534	Positive_regulation	denotes	autocrine
T10385	4513-4521	Positive_regulation	denotes	increase
T10384	4314-4320	Positive_regulation	denotes	caused
T10383	4540-4549	Gene_expression	denotes	synthesis
T10382	4379-4388	Positive_regulation	denotes	increased
T10381	4330-4342	Positive_regulation	denotes	upregulation
T10380	4149-4158	Positive_regulation	denotes	triggered
T10379	4164-4173	Positive_regulation	denotes	induction
T10378	3964-3973	Regulation	denotes	dependent
T10377	4045-4054	Positive_regulation	denotes	increased
T10376	4038-4044	Transcription	denotes	levels
T10375	3974-3982	Positive_regulation	denotes	increase
T10374	3911-3921	Positive_regulation	denotes	contribute
T10373	3930-3939	Gene_expression	denotes	synthesis
T10372	3799-3808	Positive_regulation	denotes	increased
T10371	3809-3818	Gene_expression	denotes	synthesis
T10370	3631-3643	Positive_regulation	denotes	upregulation
T10369	3223-3232	Negative_regulation	denotes	knockdown
T10368	3157-3165	Positive_regulation	denotes	required
T10367	3169-3174	Negative_regulation	denotes	block
T10366	3178-3193	Phosphorylation	denotes	phosphorylation
T10365	3076-3085	Negative_regulation	denotes	inhibitor
T10364	2817-2826	Regulation	denotes	regulates
T10363	2847-2857	Positive_regulation	denotes	activation
T10362	2785-2792	Positive_regulation	denotes	induced
T10361	2373-2382	Negative_regulation	denotes	inhibitor
T10360	936-951	Phosphorylation	denotes	phosphorylation
T10359	648-658	Positive_regulation	denotes	pronounced
T10355	5627-5631	Protein	denotes	bFGF
T10354	5568-5572	Protein	denotes	TNFα
T30896	5022-5028	Transcription	denotes	levels
T30895	4618-4627	Positive_regulation	denotes	autocrine
T30894	4633-4642	Gene_expression	denotes	synthesis
T30893	5184-5189	Protein	denotes	mTNFα
T30892	5137-5141	Protein	denotes	TNFα
T30891	5012-5016	Protein	denotes	TNFα
T30890	4906-4910	Protein	denotes	TNFα
T30889	4854-4857	Protein	denotes	18S
T30888	4818-4823	Protein	denotes	mTNFα
T30887	4738-4742	Protein	denotes	bFGF
T30886	4628-4632	Protein	denotes	TNFα
T30564	1928-1932	Protein	denotes	TNFα
T30563	1715-1719	Protein	denotes	TNFα
T30562	1562-1566	Protein	denotes	bFGF
T30561	1554-1558	Protein	denotes	bFGF
T30560	1454-1458	Protein	denotes	TNFα
R6701	T10315	T10357	themeOf	double minute 2,phosphorylation
R6702	T10316	T10357	themeOf	MDM2,phosphorylation
R6703	T10317	T10357	themeOf	p70 ribosomal protein S6 Kinase,phosphorylation
R6704	T10318	T10357	themeOf	p70S6K,phosphorylation
R6705	T10319	T10357	themeOf	S6,phosphorylation
R6706	T10323	T10359	themeOf	GSK-3α,pronounced
R6707	T10324	T10359	themeOf	β,pronounced
R6708	T10325	T10359	themeOf	p70S6K,pronounced
R6709	T10326	T10359	themeOf	S6,pronounced
R6710	T10327	T10359	themeOf	FoxO3a,pronounced
R6711	T10328	T10360	themeOf	pFoxO1,phosphorylation
R6712	T10330	T10361	themeOf	Raptor,inhibitor
R6713	T10331	T10362	themeOf	TNFα,induced
R6714	T10332	T10363	themeOf	p70S6 kinase,activation
R6715	T10333	T10364	causeOf	S6,regulates
R6716	T10334	T10365	themeOf	p70S6K,inhibitor
R6717	T10335	T10366	themeOf	S6,phosphorylation
R6718	T10336	T10369	themeOf	S6,knockdown
R6719	T10340	T10370	themeOf	TNFα,upregulation
R6720	T10341	T10371	themeOf	TNFα,synthesis
R6721	T10342	T10373	themeOf	TNFα,synthesis
R6722	T10343	T10378	causeOf	RIP1,dependent
R6723	T10344	T10375	themeOf	TNFα,increase
R6724	T10345	T10376	themeOf	TNFα,levels
R6725	T10346	T10377	themeOf	RIP1,increased
R6726	T10347	T10380	causeOf	bFGF,triggered
R6727	T10348	T10379	themeOf	TNFα,induction
R6728	T10349	T10381	themeOf	TNFα,upregulation
R6729	T10350	T10383	themeOf	TNFα,synthesis
R6730	T10351	T10387	themeOf	TNFα,upregulation
R6731	T10352	T10388	themeOf	TNFα,levels
R6732	T10353	T10390	themeOf	RIP1,inhibitors
R6733	T10354	T10391	themeOf	TNFα,mRNA
R6734	T10355	T10392	themeOf	bFGF,stimulated
R6735	T10356	T10393	themeOf	TNFα,synthesis
R6736	T10357	T10358	themeOf	phosphorylation,increase
R6737	T10357	T10358	themeOf	phosphorylation,increase
R6738	T10357	T10358	themeOf	phosphorylation,increase
R6739	T10357	T10358	themeOf	phosphorylation,increase
R6740	T10357	T10358	themeOf	phosphorylation,increase
R6741	T10363	T10364	themeOf	activation,regulates
R6742	T10366	T10367	themeOf	phosphorylation,block
R6743	T10367	T10368	themeOf	block,required
R6744	T10371	T10372	themeOf	synthesis,increased
R6745	T10373	T10374	themeOf	synthesis,contribute
R6746	T10375	T10378	themeOf	increase,dependent
R6747	T10376	T10377	themeOf	levels,increased
R6748	T10379	T10380	themeOf	induction,triggered
R6749	T10381	T10382	themeOf	upregulation,increased
R6750	T10381	T10384	themeOf	upregulation,caused
R6751	T10383	T10385	themeOf	synthesis,increase
R6752	T10383	T10386	themeOf	synthesis,autocrine
R6753	T10387	T10389	themeOf	upregulation,contribute
R6754	T10390	T10394	causeOf	inhibitors,effect
R6755	T10391	T10394	themeOf	mRNA,effect
R6756	T10393	T10395	themeOf	synthesis,increase
R6757	T10395	T10396	themeOf	increase,mediate
R6758	T10395	T10397	themeOf	increase,necroptosis-dependent
R21356	T30886	T30894	themeOf	TNFα,synthesis
R21357	T30891	T30896	themeOf	TNFα,levels
R21358	T30894	T30895	themeOf	synthesis,autocrine

bionlp-st-ge-2016-test-ihmc

Id	Subject	Object	Predicate	Lexical cue
T31152	4647-4680	Positive_regulation	denotes	JNK activation during necroptosis
T31151	5071-5074	Protein	denotes	Akt
T31150	4686-4691	Entity	denotes	Cells
T31149	4970-4974	Protein	denotes	VIII
T31148	4767-4775	Entity	denotes	zVAD.fmk
T31147	4845-4861	Protein	denotes	to mouse 18S RNA
T31146	5125-5133	Entity	denotes	zVAD.fmk
T31145	4961-4968	Entity	denotes	Akt inh
T31144	4802-4805	Protein	denotes	PCR
T31143	4618-4642	Protein	denotes	autocrine TNFα synthesis
T31142	4815-4823	Protein	denotes	of mTNFα
T31141	5093-5101	Protein	denotes	mTOR (D,
T31140	4738-4742	Protein	denotes	bFGF
T31139	5093-5102	Entity	denotes	mTOR (D,F
T31138	5054-5057	Protein	denotes	RNA
T31137	4933-4957	Protein	denotes	Nec-1, rapamycin (rapa),
T31136	4970-4978	Entity	denotes	VIII inh
T31135	4746-4750	Entity	denotes	PDGF
T31134	4940-4956	Entity	denotes	rapamycin (rapa)
T31133	5009-5028	Protein	denotes	of TNFα mRNA levels
T31132	5052-5054	Entity	denotes	si
T31131	4906-4910	Protein	denotes	TNFα
T31130	5168-5171	Protein	denotes	PCR
T31129	4595-4598	Protein	denotes	Akt
T31128	4914-4957	Entity	denotes	cells treated with Nec-1, rapamycin (rapa),
T31127	4951-4955	Protein	denotes	rapa
T31126	5137-5141	Protein	denotes	TNFα
T31125	4894-4902	Entity	denotes	zVAD.fmk
T31124	5181-5189	Protein	denotes	of mTNFα
T31123	4854-4857	Protein	denotes	18S
T31122	4961-4964	Protein	denotes	Akt
T31121	4647-4650	Protein	denotes	JNK
T31120	4603-4609	Entity	denotes	mTORC1
T31119	4992-4999	Protein	denotes	qRT-PCR
T31118	5012-5016	Protein	denotes	TNFα
T30629	1554-1558	Protein	denotes	bFGF
T30628	1916-1924	Entity	denotes	zVAD.fmk
T30627	1660-1670	Entity	denotes	antibodies
T30626	1928-1943	Protein	denotes	TNFα for 24 hrs
T30625	1703-1711	Entity	denotes	zVAD.fmk
T30624	1795-1804	Entity	denotes	rapamycin
T30623	1562-1566	Protein	denotes	bFGF
T30622	1847-1851	Protein	denotes	mTOR
T30621	1766-1769	Protein	denotes	Akt
T30620	1818-1824	Entity	denotes	PI-103
T30619	1789-1825	Protein	denotes	mTOR (rapamycin, Torin-1 and PI-103)
T30618	1357-1362	Entity	denotes	TORC1
T30617	1454-1467	Protein	denotes	TNFα for 9 hr
T30616	1504-1535	Entity	denotes	Cell under serum free condition
T30615	1831-1867	Entity	denotes	L929 cells with mTOR siRNA knockdown
T30614	1806-1813	Entity	denotes	Torin-1
T30613	1567-1575	Entity	denotes	zVAD.fmk
T30612	1779-1783	Protein	denotes	VIII
T30611	1442-1450	Entity	denotes	zVAD.fmk
T30610	1715-1719	Protein	denotes	TNFα
T30609	1770-1773	Protein	denotes	Akt
T30608	1752-1762	Entity	denotes	inhibitors
T30607	1937-1943	Protein	denotes	24 hrs
T30606	1770-1777	Entity	denotes	Akt inh
T30605	1831-1835	Entity	denotes	L929
T10939	168-205	Positive_regulation	denotes	in an increase in Akt kinase activity
T10938	5672-5760	Regulation	denotes	that these kinases specifically mediate necroptosis-dependent increase in TNFα synthesis
T10937	2993-3027	Translation	denotes	protein translation in necroptosis
T10936	5712-5760	Regulation	denotes	necroptosis-dependent increase in TNFα synthesis
T10935	3169-3193	Negative_regulation	denotes	block S6 phosphorylation
T10934	5324-5372	Positive_regulation	denotes	the upregulation of TNFα mRNA during necroptosis
T10933	3627-3676	Positive_regulation	denotes	the upregulation of TNFα accompanying necroptosis
T10932	98-159	Positive_regulation	denotes	the necroptosis-associated increase in Thr308 phosphorylation
T10931	3175-3193	Phosphorylation	denotes	S6 phosphorylation
T10930	3952-3998	Regulation	denotes	with a RIP1-dependent increase in TNFα protein
T10929	2847-2873	Positive_regulation	denotes	activation of p70S6 kinase
T10928	207-316	Positive_regulation	denotes	Under necroptotic conditions, we observed an increase in the phosphorylation of multiple known Akt substrates
T10927	3544-3560	Positive_regulation	denotes	of Akt signaling
T10926	739-768	Phosphorylation	denotes	Akt phosphorylation (Fig. 5B,
T10925	4321-4356	Positive_regulation	denotes	a modest upregulation of TNFα mRNA,
T10924	2811-2873	Regulation	denotes	TORC1 regulates translation through activation of p70S6 kinase
T10923	4159-4186	Gene_expression	denotes	some induction of TNFα mRNA
T10922	4159-4186	Positive_regulation	denotes	some induction of TNFα mRNA
T10921	437-481	Protein	denotes	p70 ribosomal protein S6 Kinase (p70S6K), S6
T10920	2639-2642	Protein	denotes	RNA
T10919	3089-3095	Protein	denotes	p70S6K
T10918	4233-4241	Entity	denotes	zVAD.fmk
T10917	2893-2918	Protein	denotes	ribosomal protein S6 [32]
T10916	3233-3288	Protein	denotes	of S6 protein attenuated necroptosis as well (Fig. S5E)
T10915	186-196	Protein	denotes	Akt kinase
T10914	4138-4142	Protein	denotes	bFGF
T10913	5639-5642	Protein	denotes	Fig
T10912	5430-5433	Protein	denotes	Akt
T10911	516-521	Protein	denotes	FoxO4
T10910	356-361	Protein	denotes	GSK-3
T10909	2346-2355	Entity	denotes	of mTORC1
T10908	3599-3603	Protein	denotes	Akt,
T10907	1103-1121	Protein	denotes	by Nec-1 (Fig. 5A,
T10906	2373-2460	Entity	denotes	inhibitor of the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C)
T10905	2858-2873	Protein	denotes	of p70S6 kinase
T10904	3754-3765	Entity	denotes	by zVAD.fmk
T10903	2993-3000	Protein	denotes	protein
T10902	1073-1087	Entity	denotes	Akt substrates
T10901	3986-3990	Protein	denotes	TNFα
T10900	5743-5760	Protein	denotes	in TNFα synthesis
T10899	739-742	Protein	denotes	Akt
T10898	4346-4350	Protein	denotes	TNFα
T10897	4215-4223	Entity	denotes	zVAD.fmk
T10896	793-799	Protein	denotes	pFoxO1
T10895	509-527	Protein	denotes	FoxO1, FoxO4, MDM2
T10894	3586-3590	Protein	denotes	RIP1
T10893	586-594	Protein	denotes	GSK-3α/β
T10892	1073-1076	Protein	denotes	Akt
T10891	5581-5594	Entity	denotes	control cells
T10890	5627-5631	Protein	denotes	bFGF
T10889	4023-4087	Protein	denotes	that TNFα mRNA levels increased during necroptosis in L929 cells
T10888	3331-3340	Protein	denotes	p70S6K/S6
T10887	3983-3998	Protein	denotes	in TNFα protein
T10886	1288-1292	Protein	denotes	RIP1
T10885	5677-5690	Protein	denotes	these kinases
T10884	904-907	Protein	denotes	Fig
T10883	346-403	Protein	denotes	proteins, GSK-3 kinases and mouse double minute 2 (MDM2))
T10882	2717-2721	Protein	denotes	mTOR
T10881	186-189	Protein	denotes	Akt
T10880	4099-4102	Protein	denotes	Fig
T10879	578-584	Protein	denotes	FoxO3a
T10878	3338-3340	Protein	denotes	S6
T10877	4408-4427	Entity	denotes	zVAD.fmk (Fig. 6A),
T10876	2183-2189	Entity	denotes	mTORC1
T10875	2811-2816	Entity	denotes	TORC1
T10874	3195-3198	Protein	denotes	Fig
T10873	5568-5572	Protein	denotes	TNFα
T10872	5438-5442	Protein	denotes	mTOR
T10871	596-602	Protein	denotes	p70S6K
T10870	2405-2416	Protein	denotes	Raptor [29]
T10869	5601-5621	Entity	denotes	the cells stimulated
T10868	3586-3597	Protein	denotes	RIP1 kinase
T10867	2522-2562	Protein	denotes	the dual PI3K/mTOR inhibitor PI-103 [31]
T10866	2390-2394	Protein	denotes	mTOR
T10865	607-623	Protein	denotes	its substrate S6
T10864	5513-5517	Protein	denotes	RIP1
T10863	509-522	Protein	denotes	FoxO1, FoxO4,
T10862	3925-3939	Protein	denotes	TNFα synthesis
T10861	2053-2063	Protein	denotes	Akt kinase
T10860	356-369	Protein	denotes	GSK-3 kinases
T10859	4174-4186	Protein	denotes	of TNFα mRNA
T10858	5344-5348	Protein	denotes	TNFα
T10857	2800-2803	Protein	denotes	Fig
T10856	2496-2505	Entity	denotes	inhibitor
T10855	2484-2488	Protein	denotes	mTOR
T10854	4177-4181	Protein	denotes	TNFα
T10853	3057-3111	Entity	denotes	the small molecule inhibitor of p70S6K PF-4708671 [33]
T10852	340-344	Entity	denotes	FoxO
T10851	5451-5467	Protein	denotes	TNFα mRNA levels
T10850	3959-3973	Protein	denotes	RIP1-dependent
T10849	5522-5525	Protein	denotes	Akt
T10848	2626-2630	Protein	denotes	mTOR
T10847	415-482	Entity	denotes	downstream molecules (p70 ribosomal protein S6 Kinase (p70S6K), S6)
T10846	5295-5298	Protein	denotes	Akt
T10845	2386-2460	Entity	denotes	the mTOR co-factor Raptor [29], protected cells from necroptosis (Fig. 5C)
T10844	397-401	Protein	denotes	MDM2
T10843	5490-5493	Protein	denotes	Fig
T10842	5341-5353	Protein	denotes	of TNFα mRNA
T10841	2496-2517	Entity	denotes	inhibitor Torin1 [30]
T10840	974-979	Entity	denotes	Thr24
T10839	2084-2212	Protein	denotes	a pro-survival protein that inhibits apoptosis through the control of multiple effectors including mTORC1, GSK-3 and others [28]
T10838	1209-1212	Protein	denotes	Akt
T10837	3089-3106	Entity	denotes	p70S6K PF-4708671
T10836	137-143	Entity	denotes	Thr308
T10835	2473-2495	Protein	denotes	the direct mTOR kinase
T10834	2053-2056	Protein	denotes	Akt
T10833	4-7	Protein	denotes	Akt
T10832	5451-5455	Protein	denotes	TNFα
T10831	2751-2756	Entity	denotes	cells
T10830	2541-2550	Entity	denotes	inhibitor
T10829	3411-3414	Protein	denotes	Akt
T10828	4033-4037	Protein	denotes	mRNA
T10827	437-478	Protein	denotes	p70 ribosomal protein S6 Kinase (p70S6K),
T10826	3644-3676	Protein	denotes	of TNFα accompanying necroptosis
T10825	3822-3856	Protein	denotes	TNFα, which potentiates cell death
T10824	4093-4097	Protein	denotes	RIP1
T10823	3175-3177	Protein	denotes	S6
T10822	2191-2196	Protein	denotes	GSK-3
T10821	2680-2689	Entity	denotes	inhibitor
T10820	2780-2784	Protein	denotes	TNFα
T10819	5471-5488	Entity	denotes	necroptotic cells
T10818	4343-4356	Protein	denotes	of TNFα mRNA,
T10817	2356-2369	Entity	denotes	by rapamycin,
T10816	2623-2639	Entity	denotes	of mTOR using si
T10815	3239-3246	Protein	denotes	protein
T10814	607-623	Entity	denotes	its substrate S6
T10813	302-305	Protein	denotes	Akt
T10812	1122-1125	Protein	denotes	Fig
T10811	2247-2267	Entity	denotes	these same molecules
T10810	586-594	Protein	denotes	GSK-3α/β
T10809	5522-5536	Entity	denotes	Akt inhibitors
T10808	470-476	Protein	denotes	p70S6K
T10807	3889-3892	Protein	denotes	Akt
T10806	5381-5395	Entity	denotes	small-molecule
T10805	374-402	Protein	denotes	mouse double minute 2 (MDM2)
T10804	3547-3550	Protein	denotes	Akt
T10803	3599-3610	Entity	denotes	Akt, mTORC1
T10802	2522-2562	Entity	denotes	the dual PI3K/mTOR inhibitor PI-103 [31]
T10801	5565-5577	Protein	denotes	of TNFα mRNA
T10800	5650-5653	Protein	denotes	Fig
T10799	4522-4549	Protein	denotes	in autocrine TNFα synthesis
T10798	3331-3340	Protein	denotes	p70S6K/S6
T10797	593-594	Protein	denotes	β
T10796	2767-2775	Entity	denotes	zVAD.fmk
T10795	3615-3618	Protein	denotes	JNK
T10794	3057-3111	Entity	denotes	the small molecule inhibitor of p70S6K PF-4708671 [33]
T10793	5304-5309	Entity	denotes	TORC1
R6962	T10804	T10927	causeOf	Akt,of Akt signaling
R6963	T10818	T10925	themeOf	"of TNFα mRNA,","a modest upregulation of TNFα mRNA,"
R6964	T10823	T10931	themeOf	S6,S6 phosphorylation
R6965	T10826	T10933	themeOf	of TNFα accompanying necroptosis,the upregulation of TNFα accompanying necroptosis
R6966	T10842	T10934	themeOf	of TNFα mRNA,the upregulation of TNFα mRNA during necroptosis
R6967	T10850	T10930	causeOf	RIP1-dependent,with a RIP1-dependent increase in TNFα protein
R6968	T10859	T10922	themeOf	of TNFα mRNA,some induction of TNFα mRNA
R6969	T10859	T10923	themeOf	of TNFα mRNA,some induction of TNFα mRNA
R6970	T10875	T10924	causeOf	TORC1,TORC1 regulates translation through activation of p70S6 kinase
R6971	T10885	T10938	causeOf	these kinases,that these kinases specifically mediate necroptosis-dependent increase in TNFα synthesis
R6972	T10899	T10926	themeOf	Akt,"Akt phosphorylation (Fig. 5B,"
R6973	T10903	T10937	themeOf	protein,protein translation in necroptosis
R6974	T10905	T10929	themeOf	of p70S6 kinase,activation of p70S6 kinase
R6975	T10915	T10939	themeOf	Akt kinase,in an increase in Akt kinase activity
R6976	T10931	T10935	themeOf	S6 phosphorylation,block S6 phosphorylation
R21540	T31121	T31152	themeOf	JNK,JNK activation during necroptosis

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T31091	5256-5257	.	denotes	.
T31090	5249-5256	VBN	denotes	plotted
T31089	5245-5248	VBD	denotes	was
T31088	5242-5244	NNP	denotes	SD
T31087	5241-5242	NN	denotes	±
T31086	5234-5241	JJ	denotes	average
T31085	5232-5233	,	denotes	,
T31084	5226-5232	NNS	denotes	graphs
T31083	5222-5225	DT	denotes	all
T31082	5219-5221	IN	denotes	In
T31081	5217-5218	.	denotes	.
T31080	5216-5217	-RRB-	denotes	)
T31079	5215-5216	NN	denotes	F
T31078	5214-5215	,	denotes	,
T31077	5213-5214	NNP	denotes	E
T31076	5212-5213	-LRB-	denotes	(
T31075	5207-5211	NN	denotes	blot
T31074	5199-5206	JJ	denotes	western
T31073	5196-5198	CC	denotes	or
T31072	5194-5195	-RRB-	denotes	)
T31071	5193-5194	NNP	denotes	D
T31070	5192-5193	,	denotes	,
T31069	5191-5192	NNP	denotes	C
T31068	5190-5191	-LRB-	denotes	(
T31067	5184-5189	NNP	denotes	mTNFα
T31066	5181-5183	IN	denotes	of
T31065	5172-5180	NN	denotes	analysis
T31064	5164-5171	JJ	denotes	qRT-PCR
T31022	4992-4999	JJ	denotes	qRT-PCR
T31021	4989-4991	IN	denotes	by
T31020	4980-4988	VBN	denotes	followed
T31019	4978-4979	.	denotes	.
T31018	4975-4978	NN	denotes	inh
T31017	4970-4974	NNP	denotes	VIII
T31016	4968-4969	.	denotes	.
T31015	4965-4968	NN	denotes	inh
T31014	4961-4964	NNP	denotes	Akt
T31013	4958-4960	CC	denotes	or
T31012	4956-4957	,	denotes	,
T31011	4955-4956	-RRB-	denotes	)
T31010	4951-4955	NN	denotes	rapa
T31009	4950-4951	-LRB-	denotes	(
T31008	4940-4949	NN	denotes	rapamycin
T31007	4938-4939	,	denotes	,
T31006	4933-4938	NN	denotes	Nec-1
T31005	4928-4932	IN	denotes	with
T31004	4920-4927	VBN	denotes	treated
T31003	4914-4919	NNS	denotes	cells
T31002	4911-4913	IN	denotes	in
T31001	4906-4910	NNP	denotes	TNFα
T31000	4903-4905	CC	denotes	or
T30999	4894-4902	NNP	denotes	zVAD.fmk
T30998	4891-4893	IN	denotes	by
T30997	4883-4890	VBN	denotes	induced
T30996	4879-4882	VBD	denotes	was
T30995	4867-4878	NNP	denotes	Necroptosis
T30994	4865-4866	-RRB-	denotes	)
T30993	4864-4865	NNP	denotes	B
T30992	4863-4864	-LRB-	denotes	(
T30991	4861-4862	.	denotes	.
T30990	4858-4861	NNP	denotes	RNA
T30989	4854-4857	CD	denotes	18S
T30988	4848-4853	NN	denotes	mouse
T30987	4845-4847	TO	denotes	to
T30986	4834-4844	VBN	denotes	normalized
T30985	4830-4833	VBD	denotes	was
T30984	4825-4829	NNP	denotes	Data
T30983	4823-4824	.	denotes	.
T30982	4818-4823	NNP	denotes	mTNFα
T30981	4815-4817	IN	denotes	of
T30980	4806-4814	NN	denotes	analysis
T30979	4798-4805	JJ	denotes	qRT-PCR
T30978	4795-4797	IN	denotes	by
T30977	4786-4794	VBN	denotes	followed
T30976	4784-4785	,	denotes	,
T30975	4782-4784	NN	denotes	hr
T30974	4780-4781	CD	denotes	9
T30973	4776-4779	IN	denotes	for
T30972	4767-4775	NNP	denotes	zVAD.fmk
T30971	4759-4766	IN	denotes	without
T30970	4756-4758	CC	denotes	or
T30969	4751-4755	IN	denotes	with
T30968	4746-4750	NNP	denotes	PDGF
T30967	4743-4745	CC	denotes	or
T30966	4738-4742	NNP	denotes	bFGF
T30965	4733-4737	IN	denotes	with
T30964	4722-4732	NNS	denotes	conditions
T30963	4717-4721	JJ	denotes	free
T30962	4711-4716	NN	denotes	serum
T30961	4705-4710	IN	denotes	under
T30960	4697-4704	VBN	denotes	treated
T30959	4692-4696	VBD	denotes	were
T30958	4686-4691	NNPS	denotes	Cells
T30957	4684-4685	-RRB-	denotes	)
T30956	4683-4684	NNP	denotes	A
T30955	4682-4683	-LRB-	denotes	(
T30954	4680-4681	.	denotes	.
T30953	4669-4680	NN	denotes	necroptosis
T30952	4662-4668	IN	denotes	during
T30951	4651-4661	NN	denotes	activation
T30950	4647-4650	NNP	denotes	JNK
T30949	4643-4646	CC	denotes	and
T30948	4633-4642	NN	denotes	synthesis
T30947	4628-4632	NNP	denotes	TNFα
T30946	4618-4627	NN	denotes	autocrine
T30945	4610-4617	NN	denotes	control
T30944	4603-4609	NNP	denotes	mTORC1
T30943	4599-4602	CC	denotes	and
T30942	4595-4598	NNP	denotes	Akt
T31063	5161-5163	IN	denotes	by
T31062	5152-5160	VBN	denotes	followed
T31061	5150-5151	,	denotes	,
T31060	5148-5150	NN	denotes	hr
T31059	5146-5147	CD	denotes	9
T31058	5142-5145	IN	denotes	for
T31057	5137-5141	NNP	denotes	TNFα
T31056	5134-5136	CC	denotes	or
T31055	5125-5133	NNP	denotes	zVAD.fmk
T31054	5120-5124	IN	denotes	with
T31053	5109-5119	VBN	denotes	stimulated
T31052	5104-5108	VBD	denotes	were
T31051	5102-5103	-RRB-	denotes	)
T31050	5101-5102	NN	denotes	F
T31049	5100-5101	,	denotes	,
T31048	5099-5100	NNP	denotes	D
T31047	5098-5099	-LRB-	denotes	(
T31046	5093-5097	NNP	denotes	mTOR
T31045	5090-5092	CC	denotes	or
T31044	5088-5089	-RRB-	denotes	)
T31043	5087-5088	NNP	denotes	E
T31042	5086-5087	,	denotes	,
T31041	5085-5086	NNP	denotes	C
T31040	5084-5085	-LRB-	denotes	(
T31039	5075-5083	VBZ	denotes	isoforms
T31038	5071-5074	NNP	denotes	Akt
T31037	5068-5070	IN	denotes	of
T31036	5058-5067	NN	denotes	knockdown
T31035	5052-5057	NNP	denotes	siRNA
T31034	5047-5051	IN	denotes	with
T31033	5041-5046	NNS	denotes	cells
T31032	5036-5040	CD	denotes	L929
T31031	5034-5035	-RRB-	denotes	)
T31030	5031-5034	NN	denotes	C-F
T31029	5030-5031	-LRB-	denotes	(
T31028	5028-5029	.	denotes	.
T31027	5022-5028	NNS	denotes	levels
T31026	5017-5021	NNP	denotes	mRNA
T31025	5012-5016	NNP	denotes	TNFα
T31024	5009-5011	IN	denotes	of
T31023	5000-5008	NN	denotes	analysis
T30541	2051-2052	.	denotes	.
T30540	2044-2051	VBN	denotes	plotted
T30539	2040-2043	VBD	denotes	was
T30538	2037-2039	NNP	denotes	SD
T30537	2036-2037	NN	denotes	±
T30536	2029-2036	JJ	denotes	average
T30535	2027-2028	,	denotes	,
T30534	2021-2027	NNS	denotes	graphs
T30533	2017-2020	DT	denotes	all
T30532	2014-2016	IN	denotes	In
T30531	2012-2013	.	denotes	.
T30530	2001-2012	NN	denotes	necroptosis
T30529	1998-2000	IN	denotes	of
T30528	1987-1997	NN	denotes	activation
T30527	1981-1986	IN	denotes	after
T30526	1978-1980	NN	denotes	hr
T30525	1975-1977	CD	denotes	24
T30524	1964-1974	VBN	denotes	determined
T30523	1960-1963	VBD	denotes	was
T30522	1950-1959	NN	denotes	viability
T30521	1945-1949	NNP	denotes	Cell
T30520	1943-1944	.	denotes	.
T30475	1736-1739	DT	denotes	the
T30474	1733-1735	IN	denotes	in
T30473	1728-1732	NN	denotes	cell
T30472	1723-1727	NNP	denotes	L929
T30471	1720-1722	IN	denotes	in
T30470	1715-1719	NNP	denotes	TNFα
T30469	1712-1714	CC	denotes	or
T30468	1703-1711	NNP	denotes	zVAD.fmk
T30467	1700-1702	IN	denotes	by
T30466	1692-1699	VBN	denotes	induced
T30465	1688-1691	VBD	denotes	was
T30464	1676-1687	NNP	denotes	Necroptosis
T30463	1674-1675	-RRB-	denotes	)
T30462	1673-1674	NNP	denotes	C
T30461	1672-1673	-LRB-	denotes	(
T30460	1670-1671	.	denotes	.
T30459	1660-1670	NNS	denotes	antibodies
T30458	1650-1659	VBN	denotes	indicated
T30457	1646-1649	DT	denotes	the
T30456	1640-1645	VBG	denotes	using
T30455	1631-1639	VBG	denotes	blotting
T30454	1623-1630	JJ	denotes	western
T30453	1620-1622	IN	denotes	by
T30452	1611-1619	VBN	denotes	followed
T30451	1609-1610	,	denotes	,
T30450	1605-1609	NN	denotes	time
T30449	1602-1604	IN	denotes	of
T30448	1594-1601	NNS	denotes	amounts
T30447	1584-1593	JJ	denotes	indicated
T30446	1580-1583	DT	denotes	the
T30445	1576-1579	IN	denotes	for
T30444	1572-1575	NN	denotes	fmk
T30443	1571-1572	.	denotes	.
T30442	1562-1571	NNP	denotes	bFGF/zVAD
T30441	1559-1561	CC	denotes	or
T30440	1554-1558	NNP	denotes	bFGF
T30439	1549-1553	IN	denotes	with
T30438	1541-1548	VBN	denotes	treated
T30437	1536-1540	VBD	denotes	were
T30436	1526-1535	NN	denotes	condition
T30435	1521-1525	JJ	denotes	free
T30434	1515-1520	NN	denotes	serum
T30433	1509-1514	IN	denotes	under
T30432	1504-1508	NNP	denotes	Cell
T30431	1502-1503	-RRB-	denotes	)
T30430	1501-1502	NNP	denotes	B
T30429	1500-1501	-LRB-	denotes	(
T30428	1498-1499	.	denotes	.
T30427	1494-1498	NN	denotes	blot
T30426	1486-1493	JJ	denotes	western
T30425	1482-1485	IN	denotes	for
T30424	1472-1481	VBN	denotes	harvested
T30423	1468-1471	CC	denotes	and
T30422	1465-1467	NN	denotes	hr
T30421	1463-1464	CD	denotes	9
T30420	1459-1462	IN	denotes	for
T30419	1454-1458	NNP	denotes	TNFα
T30418	1451-1453	CC	denotes	or
T30417	1442-1450	NNP	denotes	zVAD.fmk
T30416	1437-1441	IN	denotes	with
T30415	1429-1436	VBN	denotes	treated
T30414	1424-1428	VBD	denotes	were
T30413	1418-1423	NNS	denotes	cells
T30412	1413-1417	NNP	denotes	L929
T30411	1411-1412	-RRB-	denotes	)
T30410	1410-1411	NNP	denotes	A
T30409	1409-1410	-LRB-	denotes	(
T30408	1407-1408	.	denotes	.
T30407	1396-1407	NN	denotes	necroptosis
T30406	1393-1395	IN	denotes	of
T30405	1382-1392	NN	denotes	regulation
T30404	1378-1381	DT	denotes	the
T30403	1375-1377	TO	denotes	to
T30402	1363-1374	VBZ	denotes	contributes
T30401	1356-1362	JJ	denotes	mTORC1
T30519	1940-1943	NNS	denotes	hrs
T30518	1937-1939	CD	denotes	24
T30517	1933-1936	IN	denotes	for
T30516	1928-1932	NNP	denotes	TNFα
T30515	1925-1927	CC	denotes	or
T11727	5760-5761	.	denotes	.
T11726	5751-5760	NN	denotes	synthesis
T11725	5746-5750	NNP	denotes	TNFα
T11724	5743-5745	IN	denotes	in
T11723	5734-5742	NN	denotes	increase
T11722	5712-5733	JJ	denotes	necroptosis-dependent
T11721	5704-5711	VBP	denotes	mediate
T11720	5691-5703	RB	denotes	specifically
T11719	5683-5690	NNS	denotes	kinases
T11718	5677-5682	DT	denotes	these
T11717	5672-5676	IN	denotes	that
T11716	5661-5671	VBG	denotes	suggesting
T11715	5659-5660	,	denotes	,
T11714	5658-5659	-RRB-	denotes	)
T11713	5655-5658	CD	denotes	S6C
T11712	5653-5654	.	denotes	.
T11711	5650-5653	NNP	denotes	Fig
T11710	5648-5649	,	denotes	,
T11709	5647-5648	NNP	denotes	B
T11708	5646-5647	,	denotes	,
T11707	5644-5646	NNP	denotes	6A
T11706	5639-5643	NNP	denotes	Fig.
T11705	5638-5639	-LRB-	denotes	(
T11704	5632-5637	RB	denotes	alone
T11703	5627-5631	NNP	denotes	bFGF
T11702	5622-5626	IN	denotes	with
T11701	5611-5621	VBN	denotes	stimulated
T11700	5605-5610	NNS	denotes	cells
T11699	5601-5604	DT	denotes	the
T11698	5598-5600	IN	denotes	in
T11697	5595-5597	CC	denotes	or
T11696	5589-5594	NNS	denotes	cells
T11695	5581-5588	NN	denotes	control
T11694	5578-5580	IN	denotes	in
T11693	5573-5577	NNP	denotes	mRNA
T11692	5568-5572	NNP	denotes	TNFα
T11691	5565-5567	IN	denotes	of
T11690	5558-5564	NNS	denotes	levels
T11689	5554-5557	DT	denotes	the
T11688	5551-5553	IN	denotes	on
T11687	5544-5550	NN	denotes	effect
T11686	5541-5543	DT	denotes	no
T11685	5537-5540	VBD	denotes	had
T11684	5526-5536	NNS	denotes	inhibitors
T11683	5522-5525	NNP	denotes	Akt
T11682	5518-5521	CC	denotes	and
T11681	5513-5517	NNP	denotes	RIP1
T11680	5511-5512	,	denotes	,
T11679	5504-5511	RB	denotes	Notably
T11678	5502-5503	.	denotes	.
T11677	5501-5502	-RRB-	denotes	)
T11676	5500-5501	NNP	denotes	D
T11675	5499-5500	,	denotes	,
T11674	5498-5499	NNP	denotes	C
T11673	5497-5498	,	denotes	,
T11672	5495-5497	NNP	denotes	6B
T11671	5490-5494	NNP	denotes	Fig.
T11670	5489-5490	-LRB-	denotes	(
T11669	5483-5488	NNS	denotes	cells
T11668	5471-5482	JJ	denotes	necroptotic
T11667	5468-5470	IN	denotes	in
T11666	5461-5467	NNS	denotes	levels
T11665	5456-5460	NNP	denotes	mRNA
T11664	5451-5455	NNP	denotes	TNFα
T11663	5443-5450	VBD	denotes	reduced
T11662	5438-5442	NNP	denotes	mTOR
T11661	5434-5437	CC	denotes	and
T11660	5430-5433	NNP	denotes	Akt
T11659	5427-5429	IN	denotes	of
T11658	5417-5426	NN	denotes	knockdown
T11657	5411-5416	NN	denotes	siRNA
T11656	5407-5410	CC	denotes	and
T11655	5396-5406	NN	denotes	inhibition
T11654	5381-5395	JJ	denotes	small-molecule
T11653	5376-5380	DT	denotes	both
T11652	5373-5375	IN	denotes	as
T11651	5361-5372	NN	denotes	necroptosis
T11650	5354-5360	IN	denotes	during
T11639	5290-5294	DT	denotes	both
T11638	5285-5289	IN	denotes	that
T11637	5275-5284	VBD	denotes	suggested
T11636	5266-5274	NN	denotes	analysis
T11635	5258-5265	JJ	denotes	Further
T11634	4549-4550	.	denotes	.
T11633	4540-4549	NN	denotes	synthesis
T11632	4535-4539	NNP	denotes	TNFα
T11631	4525-4534	NN	denotes	autocrine
T11630	4522-4524	IN	denotes	in
T11629	4513-4521	NN	denotes	increase
T11628	4506-4512	JJ	denotes	marked
T11627	4504-4505	DT	denotes	a
T11626	4501-4503	IN	denotes	by
T11625	4489-4500	VBN	denotes	accompanied
T11624	4476-4488	RB	denotes	specifically
T11623	4473-4475	VBZ	denotes	is
T11622	4461-4472	NN	denotes	necroptosis
T11621	4458-4460	IN	denotes	of
T11620	4447-4457	NN	denotes	activation
T11619	4442-4446	IN	denotes	that
T11618	4428-4441	VBG	denotes	demonstrating
T11617	4426-4427	,	denotes	,
T11616	4425-4426	-RRB-	denotes	)
T11615	4423-4425	NNP	denotes	6A
T11614	4418-4422	NNP	denotes	Fig.
T11613	4417-4418	-LRB-	denotes	(
T11612	4408-4416	NNP	denotes	zVAD.fmk
T11611	4405-4407	IN	denotes	of
T11610	4396-4404	NN	denotes	presence
T11609	4392-4395	DT	denotes	the
T11608	4389-4391	IN	denotes	in
T11607	4379-4388	VBN	denotes	increased
T11606	4371-4378	JJ	denotes	further
T11605	4367-4370	RB	denotes	not
T11604	4363-4366	VBD	denotes	was
T11603	4357-4362	WDT	denotes	which
T11602	4355-4356	,	denotes	,
T11601	4351-4355	NNP	denotes	mRNA
T11600	4346-4350	NNP	denotes	TNFα
T11599	4343-4345	IN	denotes	of
T11598	4330-4342	NN	denotes	upregulation
T11597	4323-4329	JJ	denotes	modest
T11596	4321-4322	DT	denotes	a
T11595	4314-4320	VBD	denotes	caused
T11594	4309-4313	NNP	denotes	PDGF
T11593	4307-4308	,	denotes	,
T11592	4297-4307	RB	denotes	Conversely
T11591	4295-4296	.	denotes	.
T11590	4294-4295	-RRB-	denotes	)
T11589	4292-4294	NNP	denotes	6A
T11588	4287-4291	NNP	denotes	Fig.
T11587	4286-4287	-LRB-	denotes	(
T11586	4277-4285	NN	denotes	increase
T11585	4269-4276	JJ	denotes	further
T11584	4258-4268	JJ	denotes	pronounced
T11583	4256-4257	DT	denotes	a
T11582	4249-4255	VBD	denotes	caused
T11581	4247-4248	-RRB-	denotes	)
T11580	4242-4247	RB	denotes	alone
T11579	4233-4241	NNP	denotes	zVAD.fmk
T11578	4229-4232	RB	denotes	not
T11577	4225-4228	CC	denotes	but
T11576	4224-4225	-LRB-	denotes	(
T11575	4215-4223	NNP	denotes	zVAD.fmk
T11574	4210-4214	IN	denotes	with
T11573	4198-4209	NN	denotes	combination
T11572	4194-4197	PRP$	denotes	its
T11571	4188-4193	IN	denotes	while
T11570	4186-4187	,	denotes	,
T11569	4182-4186	NNP	denotes	mRNA
T11568	4177-4181	NNP	denotes	TNFα
T11567	4174-4176	IN	denotes	of
T11519	3930-3939	NN	denotes	synthesis
T11518	3925-3929	NNP	denotes	TNFα
T11517	3922-3924	TO	denotes	to
T11516	3911-3921	VBP	denotes	contribute
T11515	3901-3910	NNS	denotes	effectors
T11514	3897-3900	PRP$	denotes	its
T11513	3893-3896	CC	denotes	and
T11512	3889-3892	NNP	denotes	Akt
T11511	3881-3888	IN	denotes	whether
T11510	3872-3880	VBD	denotes	examined
T11509	3869-3871	PRP	denotes	we
T11508	3867-3868	,	denotes	,
T11507	3858-3867	RB	denotes	Therefore
T11506	3856-3857	.	denotes	.
T11505	3851-3856	NN	denotes	death
T11504	3846-3850	NN	denotes	cell
T11503	3834-3845	VBZ	denotes	potentiates
T11502	3828-3833	WDT	denotes	which
T11501	3826-3827	,	denotes	,
T11500	3822-3826	NNP	denotes	TNFα
T11499	3819-3821	IN	denotes	of
T11498	3809-3818	NN	denotes	synthesis
T11497	3799-3808	VBN	denotes	increased
T11496	3794-3798	IN	denotes	with
T11495	3783-3793	VBN	denotes	associated
T11494	3780-3782	VBZ	denotes	is
T11493	3774-3779	NNS	denotes	cells
T11492	3769-3773	NNP	denotes	L929
T11491	3766-3768	IN	denotes	in
T11490	3757-3765	NNP	denotes	zVAD.fmk
T11489	3754-3756	IN	denotes	by
T11488	3742-3753	NN	denotes	necroptosis
T11487	3739-3741	IN	denotes	of
T11486	3729-3738	NN	denotes	induction
T11485	3725-3728	DT	denotes	the
T11484	3720-3724	IN	denotes	that
T11483	3711-3719	VBN	denotes	reported
T11482	3702-3710	RB	denotes	recently
T11481	3697-3701	VBP	denotes	have
T11480	3695-3696	NNP	denotes	]
T11479	3693-3695	CD	denotes	10
T11478	3692-3693	NNP	denotes	[
T11477	3688-3691	FW	denotes	al.
T11476	3685-3687	FW	denotes	et
T11475	3678-3684	NNP	denotes	Hitomi
T11474	3676-3677	.	denotes	.
T11473	3665-3676	NN	denotes	necroptosis
T11472	3652-3664	VBG	denotes	accompanying
T11471	3647-3651	NNP	denotes	TNFα
T11470	3644-3646	IN	denotes	of
T11469	3631-3643	NN	denotes	upregulation
T11468	3627-3630	DT	denotes	the
T11467	3619-3626	VBP	denotes	control
T11466	3615-3618	NNP	denotes	JNK
T11465	3611-3614	CC	denotes	and
T11464	3604-3610	NNP	denotes	mTORC1
T11463	3602-3603	,	denotes	,
T11462	3599-3602	NNP	denotes	Akt
T11461	3597-3598	,	denotes	,
T11460	3591-3597	NN	denotes	kinase
T11459	3586-3590	CD	denotes	RIP1
T11458	3584-3585	.	denotes	.
T11457	3573-3584	NN	denotes	necroptosis
T11456	3565-3572	VB	denotes	promote
T11455	3561-3564	MD	denotes	can
T11454	3551-3560	VBG	denotes	signaling
T11453	3547-3550	NNP	denotes	Akt
T11452	3544-3546	IN	denotes	of
T11451	3537-3543	NN	denotes	branch
T11450	3522-3536	JJ	denotes	anti-apoptotic
T11449	3519-3521	DT	denotes	an
T11448	3516-3518	IN	denotes	of
T11447	3507-3515	NN	denotes	activity
T11446	3503-3506	DT	denotes	the
T11445	3498-3502	IN	denotes	that
T11444	3489-3497	NN	denotes	evidence
T11443	3481-3488	VBP	denotes	provide
T11442	3476-3480	NNS	denotes	data
T11441	3472-3475	PRP$	denotes	our
T11440	3470-3471	,	denotes	,
T11439	3462-3470	VBN	denotes	explored
T11438	3456-3461	RB	denotes	fully
T11437	3453-3455	VB	denotes	be
T11436	3450-3452	TO	denotes	to
T11435	3442-3449	VBZ	denotes	remains
T11434	3430-3441	NN	denotes	necroptosis
T11433	3423-3429	IN	denotes	during
T11432	3415-3422	NNS	denotes	targets
T11431	3411-3414	NNP	denotes	Akt
T11430	3408-3410	IN	denotes	of
T11429	3397-3407	NN	denotes	repertoire
T11428	3392-3396	JJ	denotes	full
T11427	3388-3391	DT	denotes	the
T11426	3382-3387	IN	denotes	while
T11425	3380-3381	,	denotes	,
T11424	3373-3380	RB	denotes	Overall
T11423	3371-3372	.	denotes	.
T11422	3360-3371	NN	denotes	necroptosis
T11421	3357-3359	IN	denotes	in
T11420	3352-3356	NN	denotes	role
T11419	3350-3351	DT	denotes	a
T11418	3345-3349	VB	denotes	play
T11417	3341-3344	MD	denotes	may
T11416	3331-3340	NNP	denotes	p70S6K/S6
T11415	3328-3330	IN	denotes	by
T11414	3320-3327	NN	denotes	control
T11413	3306-3319	JJ	denotes	translational
T11412	3301-3305	IN	denotes	that
T11411	3290-3300	VBG	denotes	suggesting
T11410	3288-3289	,	denotes	,
T11409	3287-3288	-RRB-	denotes	)
T11408	3284-3287	CD	denotes	S5E
T11407	3282-3283	.	denotes	.
T11406	3279-3282	NNP	denotes	Fig
T11405	3278-3279	-LRB-	denotes	(
T11404	3273-3277	RB	denotes	well
T11403	3270-3272	RB	denotes	as
T11402	3258-3269	NN	denotes	necroptosis
T11401	3247-3257	VBD	denotes	attenuated
T11400	3239-3246	NN	denotes	protein
T11399	3236-3238	CD	denotes	S6
T11398	3233-3235	IN	denotes	of
T11397	3223-3232	NN	denotes	knockdown
T11396	3217-3222	NN	denotes	siRNA
T11395	3209-3216	JJ	denotes	Partial
T11394	3207-3208	.	denotes	.
T11393	3206-3207	-RRB-	denotes	)
T11392	3205-3206	NNP	denotes	D
T11391	3203-3204	,	denotes	,
T11390	3200-3203	CD	denotes	S5C
T11389	3198-3199	.	denotes	.
T11388	3195-3198	NNP	denotes	Fig
T11387	3194-3195	-LRB-	denotes	(
T11386	3178-3193	NN	denotes	phosphorylation
T11385	3175-3177	NNP	denotes	S6
T11384	3169-3174	VB	denotes	block
T11383	3166-3168	TO	denotes	to
T11382	3157-3165	VBN	denotes	required
T11381	3142-3156	NNS	denotes	concentrations
T11380	3138-3141	DT	denotes	the
T11379	3135-3137	IN	denotes	at
T11378	3123-3134	NN	denotes	necroptosis
T11377	3112-3122	VBD	denotes	attenuated
T11376	3110-3111	NNP	denotes	]
T11375	3108-3110	CD	denotes	33
T11374	3107-3108	NNP	denotes	[
T11373	3096-3106	NNP	denotes	PF-4708671
T11372	3089-3095	NNP	denotes	p70S6K
T11371	3086-3088	IN	denotes	of
T11370	3076-3085	NN	denotes	inhibitor
T11369	3067-3075	NN	denotes	molecule
T11368	3061-3066	JJ	denotes	small
T11367	3057-3060	DT	denotes	the
T11366	3052-3056	IN	denotes	that
T11365	3046-3051	VBD	denotes	found
T11364	3043-3045	PRP	denotes	we
T11363	3041-3042	,	denotes	,
T11362	3029-3041	RB	denotes	Consistently
T11361	3027-3028	.	denotes	.
T11360	3016-3027	NN	denotes	necroptosis
T11359	3013-3015	IN	denotes	in
T11358	3001-3012	NN	denotes	translation
T11357	2993-3000	NN	denotes	protein
T11356	2989-2992	IN	denotes	for
T11355	2984-2988	NN	denotes	role
T11354	2974-2983	JJ	denotes	important
T11353	2971-2973	DT	denotes	an
T11352	2961-2970	VBD	denotes	suggested
T11351	2959-2960	NNP	denotes	]
T11350	2957-2959	CD	denotes	10
T11349	2956-2957	NNP	denotes	[
T11348	2949-2955	NN	denotes	screen
T11347	2943-2948	NNP	denotes	siRNA
T11346	2931-2942	JJ	denotes	genome-wide
T11345	2929-2930	DT	denotes	a
T11344	2927-2928	,	denotes	,
T11343	2920-2927	RB	denotes	Notably
T11342	2918-2919	.	denotes	.
T11341	2917-2918	NNP	denotes	]
T11340	2915-2917	CD	denotes	32
T11339	2914-2915	NNP	denotes	[
T11338	2911-2913	NNP	denotes	S6
T11337	2903-2910	NN	denotes	protein
T11336	2893-2902	JJ	denotes	ribosomal
T11335	2891-2892	,	denotes	,
T11334	2879-2891	RB	denotes	subsequently
T11333	2877-2878	,	denotes	,
T11332	2874-2877	CC	denotes	and
T11331	2867-2873	NN	denotes	kinase
T11330	2861-2866	NNP	denotes	p70S6
T11329	2858-2860	IN	denotes	of
T11328	2847-2857	NN	denotes	activation
T11327	2839-2846	IN	denotes	through
T11326	2827-2838	NN	denotes	translation
T11325	2817-2826	VBZ	denotes	regulates
T11324	2810-2816	JJ	denotes	mTORC1
T11323	2808-2809	.	denotes	.
T11322	2807-2808	-RRB-	denotes	)
T11321	2805-2807	NNP	denotes	5D
T11320	2800-2804	NNP	denotes	Fig.
T11319	2799-2800	-LRB-	denotes	(
T11318	2793-2798	NN	denotes	death
T11317	2785-2792	VBD	denotes	induced
T11316	2780-2784	NNP	denotes	TNFα
T11315	2776-2779	CC	denotes	and
T11314	2767-2775	NNP	denotes	zVAD.fmk
T11313	2762-2766	DT	denotes	both
T11312	2757-2761	IN	denotes	from
T11311	2751-2756	NNS	denotes	cells
T11310	2740-2750	VBG	denotes	protecting
T11309	2737-2739	IN	denotes	by
T11308	2725-2736	NN	denotes	necroptosis
T11307	2722-2724	IN	denotes	in
T11306	2717-2721	NNP	denotes	mTOR
T11305	2713-2716	IN	denotes	for
T11304	2708-2712	NN	denotes	role
T11291	2613-2622	NNP	denotes	Knockdown
T11290	2611-2612	.	denotes	.
T11289	2610-2611	-RRB-	denotes	)
T11288	2608-2610	NNP	denotes	5C
T11287	2603-2607	NNP	denotes	Fig.
T11286	2602-2603	-LRB-	denotes	(
T11285	2590-2601	NN	denotes	necroptosis
T11284	2580-2589	VBN	denotes	inhibited
T11283	2568-2579	RB	denotes	efficiently
T11282	2563-2567	RB	denotes	also
T11281	2561-2562	NNP	denotes	]
T11280	2559-2561	CD	denotes	31
T11279	2558-2559	NNP	denotes	[
T11278	2551-2557	NN	denotes	PI-103
T11277	2541-2550	NN	denotes	inhibitor
T11276	2531-2540	JJ	denotes	PI3K/mTOR
T11275	2526-2530	JJ	denotes	dual
T11274	2522-2525	DT	denotes	the
T11273	2518-2521	CC	denotes	and
T11272	2516-2517	NNP	denotes	]
T11271	2514-2516	CD	denotes	30
T11270	2513-2514	NNP	denotes	[
T11269	2506-2512	NNP	denotes	Torin1
T11268	2496-2505	NN	denotes	inhibitor
T11267	2489-2495	NN	denotes	kinase
T11266	2484-2488	NNP	denotes	mTOR
T11265	2477-2483	JJ	denotes	direct
T11264	2473-2476	DT	denotes	the
T11263	2471-2472	,	denotes	,
T11262	2462-2471	RB	denotes	Similarly
T11261	2460-2461	.	denotes	.
T11260	2459-2460	-RRB-	denotes	)
T11259	2457-2459	NNP	denotes	5C
T11258	2452-2456	NNP	denotes	Fig.
T11257	2451-2452	-LRB-	denotes	(
T11256	2439-2450	NN	denotes	necroptosis
T11255	2434-2438	IN	denotes	from
T11254	2428-2433	NNS	denotes	cells
T11253	2418-2427	VBN	denotes	protected
T11252	2416-2417	,	denotes	,
T11251	2415-2416	NNP	denotes	]
T11250	2413-2415	CD	denotes	29
T11249	2412-2413	NNP	denotes	[
T11248	2405-2411	NNP	denotes	Raptor
T11247	2395-2404	NN	denotes	co-factor
T11246	2390-2394	NNP	denotes	mTOR
T11245	2386-2389	DT	denotes	the
T11244	2383-2385	IN	denotes	of
T11243	2373-2382	NN	denotes	inhibitor
T11242	2370-2372	DT	denotes	an
T11241	2368-2369	,	denotes	,
T11240	2359-2368	NN	denotes	rapamycin
T11239	2356-2358	IN	denotes	by
T11238	2349-2355	NNP	denotes	mTORC1
T11237	2346-2348	IN	denotes	of
T11236	2335-2345	NN	denotes	inhibition
T11235	2330-2334	IN	denotes	that
T11234	2324-2329	VBD	denotes	found
T11233	2321-2323	PRP	denotes	We
T11232	2319-2320	.	denotes	.
T11231	2308-2319	NN	denotes	necroptosis
T11230	2301-2307	IN	denotes	during
T11229	2295-2300	NNS	denotes	roles
T11228	2282-2294	JJ	denotes	pro-survival
T11227	2276-2281	PRP$	denotes	their
T11226	2268-2275	VBP	denotes	reverse
T11225	2258-2267	NNS	denotes	molecules
T11224	2253-2257	JJ	denotes	same
T11223	2247-2252	DT	denotes	these
T11222	2239-2246	IN	denotes	whether
T11221	2236-2238	VBZ	denotes	is
T11220	2227-2235	NN	denotes	question
T11219	2217-2226	JJ	denotes	important
T11218	2214-2216	DT	denotes	An
T11217	2212-2213	.	denotes	.
T11216	2211-2212	NNP	denotes	]
T11215	2209-2211	CD	denotes	28
T11214	2208-2209	NNP	denotes	[
T11213	2201-2207	NNS	denotes	others
T11212	2197-2200	CC	denotes	and
T11211	2191-2196	NNP	denotes	GSK-3
T11210	2189-2190	,	denotes	,
T11209	2183-2189	NNP	denotes	mTORC1
T11208	2173-2182	VBG	denotes	including
T11207	2163-2172	NNS	denotes	effectors
T11206	2154-2162	JJ	denotes	multiple
T11205	2151-2153	IN	denotes	of
T11204	2143-2150	NN	denotes	control
T11203	2139-2142	DT	denotes	the
T11202	2131-2138	IN	denotes	through
T11201	2121-2130	NN	denotes	apoptosis
T11200	2112-2120	VBZ	denotes	inhibits
T11199	2107-2111	WDT	denotes	that
T11198	2099-2106	NN	denotes	protein
T11197	2086-2098	JJ	denotes	pro-survival
T11196	2084-2085	DT	denotes	a
T11195	2081-2083	VB	denotes	be
T11194	2078-2080	TO	denotes	to
T11193	2067-2077	VBN	denotes	considered
T11192	2064-2066	VBZ	denotes	is
T11191	2057-2063	NN	denotes	kinase
T11190	2053-2056	NNP	denotes	Akt
T11189	1310-1311	.	denotes	.
T11188	1303-1310	NN	denotes	fashion
T11187	1293-1302	JJ	denotes	dependent
T11186	1288-1292	NNP	denotes	RIP1
T11185	1286-1287	DT	denotes	a
T11184	1283-1285	IN	denotes	in
T11183	1277-1282	NN	denotes	death
T11182	1272-1276	NN	denotes	cell
T11181	1260-1271	JJ	denotes	necroptotic
T11180	1257-1259	IN	denotes	of
T11179	1251-1256	NN	denotes	onset
T11178	1247-1250	DT	denotes	the
T11177	1244-1246	IN	denotes	at
T11176	1234-1243	VBN	denotes	activated
T11175	1231-1233	VBZ	denotes	is
T11174	1223-1230	NN	denotes	network
T11173	1213-1222	VBG	denotes	signaling
T11172	1209-1212	NNP	denotes	Akt
T11171	1198-1207	JJ	denotes	canonical
T11170	1193-1196	DT	denotes	the
T11169	1190-1192	IN	denotes	of
T11168	1185-1189	NN	denotes	part
T11167	1173-1184	JJ	denotes	significant
T11166	1171-1172	DT	denotes	a
T11165	1166-1170	IN	denotes	that
T11164	1156-1165	VBD	denotes	suggested
T11163	1151-1155	NNS	denotes	data
T11162	1145-1150	DT	denotes	these
T11161	1143-1144	,	denotes	,
T11160	1136-1143	RB	denotes	Overall
T11159	1134-1135	.	denotes	.
T11158	1133-1134	-RRB-	denotes	)
T11157	1132-1133	NNP	denotes	B
T11156	1130-1131	,	denotes	,
T11155	1127-1130	CD	denotes	S5A
T11154	1125-1126	.	denotes	.
T11153	1122-1125	NNP	denotes	Fig
T11152	1120-1121	,	denotes	,
T11151	1118-1120	NNP	denotes	5A
T11150	1113-1117	NNP	denotes	Fig.
T11149	1112-1113	-LRB-	denotes	(
T11148	1106-1111	NNP	denotes	Nec-1
T11147	1103-1105	IN	denotes	by
T11146	1093-1102	VBN	denotes	abrogated
T11145	1088-1092	VBD	denotes	were
T11144	1077-1087	NNS	denotes	substrates
T11143	1073-1076	NNP	denotes	Akt
T11142	1070-1072	IN	denotes	in
T11141	1060-1069	NNS	denotes	increases
T11140	1037-1059	JJ	denotes	necroptosis-associated
T11139	1033-1036	DT	denotes	the
T11138	1027-1032	NNS	denotes	cases
T11137	1023-1026	DT	denotes	all
T11136	1020-1022	IN	denotes	in
T11135	1018-1019	,	denotes	,
T11134	1011-1018	RB	denotes	Notably
T11133	1009-1010	.	denotes	.
T11132	998-1009	NN	denotes	necroptosis
T11131	991-997	IN	denotes	during
T11130	985-990	NN	denotes	place
T11129	980-984	VB	denotes	take
T11128	974-979	VB	denotes	Thr24
T11127	971-973	TO	denotes	to
T11126	962-970	NN	denotes	addition
T11125	959-961	IN	denotes	in
T11124	952-958	NNS	denotes	events
T11123	936-951	NN	denotes	phosphorylation
T11122	931-935	IN	denotes	that
T11121	920-930	VBG	denotes	suggesting
T11120	918-919	,	denotes	,
T11119	917-918	-RRB-	denotes	)
T11118	916-917	NNP	denotes	B
T11117	912-915	CC	denotes	and
T11116	909-911	NNP	denotes	5A
T11115	904-908	NNP	denotes	Fig.
T11114	894-903	VBG	denotes	comparing
T11113	889-893	FW	denotes	e.g.
T11112	888-889	-LRB-	denotes	(
T11111	878-887	NN	denotes	intensity
T11110	873-877	NN	denotes	band
T11109	870-872	IN	denotes	in
T11108	861-869	NN	denotes	increase
T11107	858-860	DT	denotes	an
T11106	853-857	IN	denotes	than
T11105	846-852	RB	denotes	rather
T11104	836-845	NN	denotes	migration
T11103	833-835	IN	denotes	in
T11102	827-832	NN	denotes	shift
T11566	4164-4173	NN	denotes	induction
T11565	4159-4163	DT	denotes	some
T11564	4149-4158	VBD	denotes	triggered
T11563	4143-4148	RB	denotes	alone
T11562	4138-4142	NNP	denotes	bFGF
T11561	4136-4137	,	denotes	,
T11560	4126-4136	NNS	denotes	conditions
T11559	4121-4125	JJ	denotes	free
T11558	4115-4120	NN	denotes	serum
T11557	4109-4114	IN	denotes	Under
T11556	4107-4108	.	denotes	.
T11555	4104-4107	CD	denotes	S6C
T11554	4102-4103	.	denotes	.
T11553	4099-4102	NNP	denotes	Fig
T11552	4098-4099	-LRB-	denotes	(
T11551	4093-4097	NNP	denotes	RIP1
T11550	4091-4092	DT	denotes	a
T11549	4088-4090	IN	denotes	in
T11548	4082-4087	NNS	denotes	cells
T11547	4077-4081	CD	denotes	L929
T11546	4074-4076	IN	denotes	in
T11545	4062-4073	NN	denotes	necroptosis
T11544	4055-4061	IN	denotes	during
T11543	4045-4054	VBD	denotes	increased
T11542	4038-4044	NNS	denotes	levels
T11541	4033-4037	NNP	denotes	mRNA
T11540	4028-4032	NNP	denotes	TNFα
T11539	4023-4027	IN	denotes	that
T11538	4017-4022	VBD	denotes	found
T11537	4014-4016	PRP	denotes	we
T11536	4012-4013	,	denotes	,
T11535	4011-4012	-RRB-	denotes	)
T11534	4010-4011	NNP	denotes	B
T11533	4008-4009	,	denotes	,
T11532	4005-4008	CD	denotes	S6A
T11531	4003-4004	.	denotes	.
T11530	4000-4003	NNP	denotes	Fig
T11529	3999-4000	-LRB-	denotes	(
T11528	3991-3998	NN	denotes	protein
T11527	3986-3990	NNP	denotes	TNFα
T11526	3983-3985	IN	denotes	in
T11525	3974-3982	NN	denotes	increase
T11524	3959-3973	JJ	denotes	RIP1-dependent
T11523	3957-3958	DT	denotes	a
T11522	3952-3956	IN	denotes	with
T11521	3941-3951	JJ	denotes	Consistent
T11520	3939-3940	.	denotes	.
T11101	825-826	DT	denotes	a
T11100	816-824	VBD	denotes	observed
T11099	803-815	RB	denotes	occasionally
T11098	800-802	PRP	denotes	we
T11097	793-799	NNP	denotes	pFoxO1
T11096	790-792	IN	denotes	of
T11095	785-789	NN	denotes	case
T11094	781-784	DT	denotes	the
T11093	778-780	IN	denotes	In
T11092	776-777	.	denotes	.
T11091	775-776	-RRB-	denotes	)
T11090	774-775	NNP	denotes	B
T11089	772-773	,	denotes	,
T11088	769-772	NNP	denotes	S5A
T11087	767-768	,	denotes	,
T11086	765-767	NNP	denotes	5B
T11085	760-764	NNP	denotes	Fig.
T11084	759-760	-LRB-	denotes	(
T11083	743-758	NN	denotes	phosphorylation
T11082	739-742	NNP	denotes	Akt
T11081	736-738	IN	denotes	in
T11080	727-735	NN	denotes	increase
T11079	723-726	DT	denotes	the
T11078	712-722	VBD	denotes	paralleled
T11077	704-711	NNS	denotes	changes
T11076	688-703	NN	denotes	phosphorylation
T10951	74-78	IN	denotes	next
T10950	71-73	PRP	denotes	We
T10949	59-70	NNP	denotes	Necroptosis
T10948	56-58	IN	denotes	of
T10947	45-55	NN	denotes	Regulation
T10946	41-44	DT	denotes	the
T10945	38-40	TO	denotes	to
T10944	26-37	VBZ	denotes	Contributes
T10943	18-25	NNP	denotes	Pathway
T10942	8-17	NNP	denotes	Signaling
T10941	4-7	NNP	denotes	Akt
T10940	0-3	DT	denotes	The
T11303	2706-2707	DT	denotes	a
T11302	2695-2705	VBG	denotes	indicating
T11301	2690-2694	NNS	denotes	data
T11300	2680-2689	NN	denotes	inhibitor
T11299	2665-2679	JJ	denotes	small-molecule
T11298	2661-2664	DT	denotes	the
T11297	2651-2660	VBD	denotes	validated
T11296	2643-2650	JJ	denotes	further
T11295	2637-2642	NNP	denotes	siRNA
T11294	2631-2636	VBG	denotes	using
T11293	2626-2630	NNP	denotes	mTOR
T11292	2623-2625	IN	denotes	of
T11075	684-687	DT	denotes	the
T11074	681-683	IN	denotes	of
T11073	674-680	NN	denotes	timing
T11072	670-673	DT	denotes	The
T11071	668-669	.	denotes	.
T11070	667-668	-RRB-	denotes	)
T11069	665-667	NNP	denotes	5A
T11068	660-664	NNP	denotes	Fig.
T11067	659-660	-LRB-	denotes	(
T11066	648-658	JJ	denotes	pronounced
T11065	643-647	RBR	denotes	less
T11064	638-642	VBD	denotes	were
T11063	630-637	NNS	denotes	changes
T11062	626-629	DT	denotes	the
T11061	624-625	,	denotes	,
T11060	623-624	-RRB-	denotes	)
T11059	621-623	NNP	denotes	S6
T11058	611-620	JJ	denotes	substrate
T11057	607-610	PRP$	denotes	its
T11056	603-606	CC	denotes	and
T11055	596-602	NNP	denotes	p70S6K
T11054	594-595	,	denotes	,
T11053	593-594	NN	denotes	β
T11052	592-593	NN	denotes	/
T11051	586-592	JJ	denotes	GSK-3α
T11050	584-585	,	denotes	,
T11049	578-584	NNS	denotes	FoxO3a
T11048	577-578	-LRB-	denotes	(
T11047	571-576	NNS	denotes	cases
T11046	565-570	JJ	denotes	other
T11045	562-564	IN	denotes	In
T11044	560-561	.	denotes	.
T11043	552-560	VBN	denotes	observed
T11042	548-551	VBD	denotes	was
T11041	539-547	NN	denotes	increase
T11040	532-538	JJ	denotes	robust
T11039	530-531	DT	denotes	a
T11038	528-529	,	denotes	,
T11037	527-528	-RRB-	denotes	)
T11036	523-527	NNP	denotes	MDM2
T11035	521-522	,	denotes	,
T11034	516-521	NNP	denotes	FoxO4
T11033	514-515	,	denotes	,
T11032	509-514	NNP	denotes	FoxO1
T11031	508-509	-LRB-	denotes	(
T11030	502-507	NNS	denotes	cases
T11029	497-501	DT	denotes	some
T11028	494-496	IN	denotes	In
T11027	492-493	.	denotes	.
T11026	491-492	-RRB-	denotes	)
T11025	489-491	NNP	denotes	5A
T11024	484-488	NNP	denotes	Fig.
T11023	483-484	-LRB-	denotes	(
T11022	481-482	-RRB-	denotes	)
T11021	479-481	NNP	denotes	S6
T11020	477-478	,	denotes	,
T11019	476-477	-RRB-	denotes	)
T11018	470-476	NNP	denotes	p70S6K
T11017	469-470	-LRB-	denotes	(
T11016	462-468	NNP	denotes	Kinase
T11015	459-461	NNP	denotes	S6
T11014	451-458	NN	denotes	protein
T11013	441-450	JJ	denotes	ribosomal
T11012	437-440	CD	denotes	p70
T11011	436-437	-LRB-	denotes	(
T11010	426-435	NNS	denotes	molecules
T11009	415-425	JJ	denotes	downstream
T11008	412-414	IN	denotes	as
T11007	407-411	RB	denotes	well
T11006	404-406	RB	denotes	as
T11005	402-403	-RRB-	denotes	)
T11004	401-402	-RRB-	denotes	)
T11003	397-401	NN	denotes	MDM2
T11002	396-397	-LRB-	denotes	(
T11001	394-395	CD	denotes	2
T11000	387-393	NN	denotes	minute
T10999	380-386	JJ	denotes	double
T10998	374-379	NN	denotes	mouse
T10997	370-373	CC	denotes	and
T10996	362-369	NNS	denotes	kinases
T10995	356-361	JJ	denotes	GSK-3
T10994	354-355	,	denotes	,
T10993	346-354	NNS	denotes	proteins
T10992	344-345	-RRB-	denotes	)
T10991	340-344	NNP	denotes	FoxO
T10990	339-340	-LRB-	denotes	(
T10989	337-338	NNP	denotes	O
T10988	331-336	NN	denotes	class
T10987	327-330	NN	denotes	box
T10986	318-326	NNP	denotes	Forkhead
T10985	317-318	-LRB-	denotes	(
T10984	306-316	VBZ	denotes	substrates
T10983	302-305	NNP	denotes	Akt
T10982	296-301	VBN	denotes	known
T10981	287-295	JJ	denotes	multiple
T10980	284-286	IN	denotes	of
T10979	268-283	NN	denotes	phosphorylation
T10978	264-267	DT	denotes	the
T10977	261-263	IN	denotes	in
T10976	252-260	NN	denotes	increase
T10975	249-251	DT	denotes	an
T10974	240-248	VBD	denotes	observed
T10973	237-239	PRP	denotes	we
T10972	235-236	,	denotes	,
T10971	225-235	NNS	denotes	conditions
T10970	213-224	JJ	denotes	necroptotic
T10969	207-212	IN	denotes	Under
T10968	205-206	.	denotes	.
T10967	197-205	NN	denotes	activity
T10966	190-196	NN	denotes	kinase
T10965	186-189	NNP	denotes	Akt
T10964	183-185	IN	denotes	in
T10963	174-182	NN	denotes	increase
T10962	171-173	DT	denotes	an
T10961	168-170	IN	denotes	in
T10960	160-167	NNS	denotes	results
T10959	144-159	NN	denotes	phosphorylation
T10958	137-143	CD	denotes	Thr308
T10957	134-136	IN	denotes	in
T10956	125-133	NN	denotes	increase
T10955	102-124	JJ	denotes	necroptosis-associated
T10954	98-101	DT	denotes	the
T10953	90-97	IN	denotes	whether
T10952	79-89	VBN	denotes	determined
T30489	1794-1795	-LRB-	denotes	(
T30488	1789-1793	NNP	denotes	mTOR
T30487	1785-1788	CC	denotes	and
T30486	1783-1784	-RRB-	denotes	)
T30485	1779-1783	NNP	denotes	VIII
T30484	1777-1778	.	denotes	.
T30483	1774-1777	NN	denotes	inh
T30482	1770-1773	NNP	denotes	Akt
T30481	1769-1770	-LRB-	denotes	(
T30480	1766-1769	NNP	denotes	Akt
T30479	1763-1765	IN	denotes	of
T30478	1752-1762	NNS	denotes	inhibitors
T30477	1749-1751	IN	denotes	of
T30476	1740-1748	NN	denotes	presence
T30514	1916-1924	NNP	denotes	zVAD.fmk
T30513	1911-1915	IN	denotes	with
T30512	1903-1910	VBN	denotes	treated
T30511	1900-1902	CC	denotes	or
T30510	1895-1899	NN	denotes	blot
T30509	1887-1894	JJ	denotes	western
T30508	1883-1886	IN	denotes	for
T30507	1873-1882	VBN	denotes	harvested
T30506	1868-1872	VBD	denotes	were
T30505	1858-1867	NN	denotes	knockdown
T30504	1852-1857	NNP	denotes	siRNA
T30503	1847-1851	NNP	denotes	mTOR
T30502	1842-1846	IN	denotes	with
T30501	1836-1841	NNS	denotes	cells
T30500	1831-1835	NNP	denotes	L929
T30499	1829-1830	-RRB-	denotes	)
T30498	1828-1829	NNP	denotes	D
T30497	1827-1828	-LRB-	denotes	(
T30496	1825-1826	.	denotes	.
T30495	1824-1825	-RRB-	denotes	)
T30494	1818-1824	NNP	denotes	PI-103
T30493	1814-1817	CC	denotes	and
T30492	1806-1813	NNP	denotes	Torin-1
T30491	1804-1805	,	denotes	,
T30490	1795-1804	NN	denotes	rapamycin
T11649	5349-5353	NNP	denotes	mRNA
T11648	5344-5348	NNP	denotes	TNFα
T11647	5341-5343	IN	denotes	of
T11646	5328-5340	NN	denotes	upregulation
T11645	5324-5327	DT	denotes	the
T11644	5321-5323	TO	denotes	to
T11643	5310-5320	VBP	denotes	contribute
T11642	5303-5309	NNP	denotes	mTORC1
T11641	5299-5302	CC	denotes	and
T11640	5295-5298	NNP	denotes	Akt
R6978	T10941	T10943	compound	Akt,Pathway
R6979	T10942	T10943	compound	Signaling,Pathway
R6980	T10943	T10944	nsubj	Pathway,Contributes
R6981	T10944	T10944	ROOT	Contributes,Contributes
R6982	T10945	T10944	prep	to,Contributes
R6983	T10946	T10947	det	the,Regulation
R6984	T10947	T10945	pobj	Regulation,to
R6985	T10948	T10947	prep	of,Regulation
R6986	T10949	T10948	pobj	Necroptosis,of
R6987	T10950	T10952	nsubj	We,determined
R6988	T10951	T10952	advmod	next,determined
R6989	T10952	T10944	ccomp	determined,Contributes
R6990	T10953	T10952	advmod	whether,determined
R6991	T10954	T10956	det	the,increase
R6992	T10955	T10956	amod	necroptosis-associated,increase
R6993	T10956	T10953	pobj	increase,whether
R6994	T10957	T10956	prep	in,increase
R6995	T10958	T10960	nummod	Thr308,results
R6996	T10959	T10960	compound	phosphorylation,results
R6997	T10960	T10957	pobj	results,in
R6998	T10961	T10956	prep	in,increase
R6999	T10962	T10963	det	an,increase
R7000	T10963	T10961	pobj	increase,in
R7001	T10964	T10963	prep	in,increase
R7002	T10965	T10967	compound	Akt,activity
R7003	T10966	T10967	compound	kinase,activity
R7004	T10967	T10964	pobj	activity,in
R7005	T10968	T10944	punct	.,Contributes
R7006	T10969	T10974	prep	Under,observed
R7007	T10970	T10971	amod	necroptotic,conditions
R7008	T10971	T10969	pobj	conditions,Under
R7009	T10972	T10974	punct	",",observed
R7010	T10973	T10974	nsubj	we,observed
R7011	T10974	T10974	ROOT	observed,observed
R7012	T10975	T10976	det	an,increase
R7013	T10976	T10974	dobj	increase,observed
R7014	T10977	T10976	prep	in,increase
R7015	T10978	T10979	det	the,phosphorylation
R7016	T10979	T10977	pobj	phosphorylation,in
R7017	T10980	T10979	prep	of,phosphorylation
R7018	T10981	T10984	amod	multiple,substrates
R7019	T10982	T10984	amod	known,substrates
R7020	T10983	T10984	compound	Akt,substrates
R7021	T10984	T10980	pobj	substrates,of
R7022	T10985	T10984	punct	(,substrates
R7023	T10986	T10993	nmod	Forkhead,proteins
R7024	T10987	T10988	compound	box,class
R7025	T10988	T10993	nmod	class,proteins
R7026	T10989	T10993	nmod	O,proteins
R7027	T10990	T10991	punct	(,FoxO
R7028	T10991	T10989	appos	FoxO,O
R7029	T10992	T10993	punct	),proteins
R7030	T10993	T10984	appos	proteins,substrates
R7031	T10994	T10993	punct	",",proteins
R7032	T10995	T10996	compound	GSK-3,kinases
R7033	T10996	T10993	conj	kinases,proteins
R7034	T10997	T10996	cc	and,kinases
R7035	T10998	T10996	conj	mouse,kinases
R7036	T10999	T11000	amod	double,minute
R7037	T11000	T10984	appos	minute,substrates
R7038	T11001	T11000	nummod	2,minute
R7039	T11002	T11003	punct	(,MDM2
R7040	T11003	T11000	appos	MDM2,minute
R7041	T11004	T10974	punct	),observed
R7042	T11005	T10974	punct	),observed
R7043	T11006	T11008	advmod	as,as
R7044	T11007	T11008	advmod	well,as
R7045	T11008	T10974	cc	as,observed
R7046	T11009	T11010	amod	downstream,molecules
R7047	T11010	T10974	conj	molecules,observed
R7048	T11011	T11010	punct	(,molecules
R7049	T11012	T11014	meta	p70,protein
R7050	T11013	T11014	compound	ribosomal,protein
R7051	T11014	T11010	appos	protein,molecules
R7052	T11015	T11016	compound	S6,Kinase
R7053	T11016	T11014	appos	Kinase,protein
R7054	T11017	T11018	punct	(,p70S6K
R7055	T11018	T11016	appos	p70S6K,Kinase
R7056	T11019	T11018	punct	),p70S6K
R7057	T11020	T11016	punct	",",Kinase
R7058	T11021	T11016	appos	S6,Kinase
R7059	T11022	T11016	punct	),Kinase
R7060	T11023	T11025	punct	(,5A
R7061	T11024	T11025	compound	Fig.,5A
R7062	T11025	T11016	appos	5A,Kinase
R7063	T11026	T11025	punct	),5A
R7064	T11027	T10974	punct	.,observed
R7065	T11028	T11043	prep	In,observed
R7066	T11029	T11030	det	some,cases
R7067	T11030	T11028	pobj	cases,In
R7068	T11031	T11043	punct	(,observed
R7069	T11032	T11041	nmod	FoxO1,increase
R7070	T11033	T11032	punct	",",FoxO1
R7071	T11034	T11032	conj	FoxO4,FoxO1
R7072	T11035	T11034	punct	",",FoxO4
R7073	T11036	T11034	conj	MDM2,FoxO4
R7074	T11037	T11034	punct	),FoxO4
R7075	T11038	T11034	punct	",",FoxO4
R7076	T11039	T11041	det	a,increase
R7077	T11040	T11041	amod	robust,increase
R7078	T11041	T11043	nsubjpass	increase,observed
R7079	T11042	T11043	auxpass	was,observed
R7080	T11043	T11043	ROOT	observed,observed
R7081	T11044	T11043	punct	.,observed
R7082	T11045	T11064	prep	In,were
R7083	T11046	T11047	amod	other,cases
R7084	T11047	T11045	pobj	cases,In
R7085	T11048	T11053	punct	(,β
R7086	T11049	T11053	nmod	FoxO3a,β
R7087	T11050	T11049	punct	",",FoxO3a
R7088	T11051	T11053	amod	GSK-3α,β
R7089	T11052	T11053	compound	/,β
R7090	T11053	T11064	dep	β,were
R7091	T11054	T11053	punct	",",β
R7092	T11055	T11053	conj	p70S6K,β
R7093	T11056	T11055	cc	and,p70S6K
R7094	T11057	T11058	poss	its,substrate
R7095	T11058	T11055	conj	substrate,p70S6K
R7096	T11059	T11058	appos	S6,substrate
R7097	T11060	T11058	punct	),substrate
R7098	T11061	T11064	punct	",",were
R7099	T11062	T11063	det	the,changes
R7100	T11063	T11064	nsubj	changes,were
R7101	T11064	T11064	ROOT	were,were
R7102	T11065	T11066	advmod	less,pronounced
R7103	T11066	T11064	acomp	pronounced,were
R7104	T11067	T11069	punct	(,5A
R7105	T11068	T11069	compound	Fig.,5A
R7106	T11069	T11069	ROOT	5A,5A
R7107	T11070	T11069	punct	),5A
R7108	T11071	T11064	punct	.,were
R7109	T11072	T11073	det	The,timing
R7110	T11073	T11078	nsubj	timing,paralleled
R7111	T11074	T11073	prep	of,timing
R7112	T11075	T11077	det	the,changes
R7113	T11076	T11077	compound	phosphorylation,changes
R7114	T11077	T11074	pobj	changes,of
R7115	T11078	T11078	ROOT	paralleled,paralleled
R7116	T11079	T11080	det	the,increase
R7117	T11080	T11078	dobj	increase,paralleled
R7118	T11081	T11080	prep	in,increase
R7119	T11082	T11083	compound	Akt,phosphorylation
R7120	T11083	T11081	pobj	phosphorylation,in
R7121	T11084	T11086	punct	(,5B
R7122	T11085	T11086	compound	Fig.,5B
R7123	T11086	T11083	appos	5B,phosphorylation
R7124	T11087	T11086	punct	",",5B
R7125	T11088	T11086	conj	S5A,5B
R7126	T11089	T11088	punct	",",S5A
R7127	T11090	T11088	conj	B,S5A
R7128	T11091	T11086	punct	),5B
R7129	T11092	T11078	punct	.,paralleled
R7130	T11093	T11100	prep	In,observed
R7131	T11094	T11095	det	the,case
R7132	T11095	T11093	pobj	case,In
R7133	T11096	T11095	prep	of,case
R7135	T11098	T11100	nsubj	we,observed
R7136	T11099	T11100	advmod	occasionally,observed
R7137	T11100	T11100	ROOT	observed,observed
R7138	T11101	T11102	det	a,shift
R7139	T11102	T11100	dobj	shift,observed
R7140	T11103	T11102	prep	in,shift
R7141	T11104	T11103	pobj	migration,in
R7142	T11105	T11106	advmod	rather,than
R7143	T11106	T11104	prep	than,migration
R7144	T11107	T11108	det	an,increase
R7145	T11108	T11106	pobj	increase,than
R7146	T11109	T11108	prep	in,increase
R7147	T11110	T11111	compound	band,intensity
R7148	T11111	T11109	pobj	intensity,in
R7149	T11112	T11113	punct	(,e.g.
R7150	T11113	T11102	appos	e.g.,shift
R7151	T11114	T11113	acl	comparing,e.g.
R7152	T11115	T11116	compound	Fig.,5A
R7153	T11116	T11114	dobj	5A,comparing
R7154	T11117	T11116	cc	and,5A
R7155	T11118	T11116	conj	B,5A
R7156	T11119	T11116	punct	),5A
R7157	T11120	T11113	punct	",",e.g.
R7158	T11121	T11113	acl	suggesting,e.g.
R7159	T11122	T11129	mark	that,take
R7160	T11123	T11124	compound	phosphorylation,events
R7161	T11124	T11129	nsubj	events,take
R7162	T11125	T11124	prep	in,events
R7163	T11126	T11125	pobj	addition,in
R7164	T11127	T11129	aux	to,take
R7165	T11128	T11129	nsubj	Thr24,take
R7166	T11129	T11121	ccomp	take,suggesting
R7167	T11130	T11129	dobj	place,take
R7168	T11131	T11129	prep	during,take
R7169	T11132	T11131	pobj	necroptosis,during
R7170	T11133	T11100	punct	.,observed
R7171	T11134	T11146	advmod	Notably,abrogated
R7172	T11135	T11146	punct	",",abrogated
R7173	T11136	T11146	prep	in,abrogated
R7174	T11137	T11138	det	all,cases
R7175	T11138	T11136	pobj	cases,in
R7176	T11139	T11141	det	the,increases
R7177	T11140	T11141	amod	necroptosis-associated,increases
R7178	T11141	T11146	nsubjpass	increases,abrogated
R7179	T11142	T11141	prep	in,increases
R7180	T11143	T11144	compound	Akt,substrates
R7181	T11144	T11142	pobj	substrates,in
R7182	T11145	T11146	auxpass	were,abrogated
R7183	T11146	T11146	ROOT	abrogated,abrogated
R7184	T11147	T11146	agent	by,abrogated
R7185	T11148	T11147	pobj	Nec-1,by
R7186	T11149	T11151	punct	(,5A
R7187	T11150	T11151	compound	Fig.,5A
R7188	T11151	T11148	appos	5A,Nec-1
R7189	T11152	T11151	punct	",",5A
R7190	T11153	T11151	appos	Fig,5A
R7191	T11154	T11146	punct	.,abrogated
R7192	T11155	T11157	npadvmod	S5A,B
R7193	T11156	T11157	punct	",",B
R7194	T11157	T11157	ROOT	B,B
R7195	T11158	T11157	punct	),B
R7196	T11159	T11157	punct	.,B
R7197	T11160	T11164	advmod	Overall,suggested
R7198	T11161	T11164	punct	",",suggested
R7199	T11162	T11163	det	these,data
R7200	T11163	T11164	nsubj	data,suggested
R7201	T11164	T11164	ROOT	suggested,suggested
R7202	T11165	T11176	mark	that,activated
R7203	T11166	T11168	det	a,part
R7204	T11167	T11168	amod	significant,part
R7205	T11168	T11176	nsubjpass	part,activated
R7206	T11169	T11168	prep	of,part
R7207	T11170	T11174	det	the,network
R7208	T11171	T11174	amod	canonical,network
R7209	T11172	T11174	nmod	Akt,network
R7210	T11173	T11174	amod	signaling,network
R7211	T11174	T11169	pobj	network,of
R7212	T11175	T11176	auxpass	is,activated
R7213	T11176	T11164	ccomp	activated,suggested
R7214	T11177	T11176	prep	at,activated
R7215	T11178	T11179	det	the,onset
R7216	T11179	T11177	pobj	onset,at
R7217	T11180	T11179	prep	of,onset
R7218	T11181	T11183	amod	necroptotic,death
R7219	T11182	T11183	compound	cell,death
R7220	T11183	T11180	pobj	death,of
R7221	T11184	T11176	prep	in,activated
R7222	T11185	T11188	det	a,fashion
R7223	T11186	T11188	amod	RIP1,fashion
R7224	T11187	T11188	amod	dependent,fashion
R7225	T11188	T11184	pobj	fashion,in
R7226	T11189	T11164	punct	.,suggested
R7227	T11190	T11191	compound	Akt,kinase
R7228	T11191	T11193	nsubjpass	kinase,considered
R7229	T11192	T11193	auxpass	is,considered
R7230	T11193	T11193	ROOT	considered,considered
R7231	T11194	T11195	aux	to,be
R7232	T11195	T11193	xcomp	be,considered
R7233	T11196	T11198	det	a,protein
R7234	T11197	T11198	amod	pro-survival,protein
R7235	T11198	T11195	attr	protein,be
R7236	T11199	T11200	nsubj	that,inhibits
R7237	T11200	T11198	relcl	inhibits,protein
R7238	T11201	T11200	dobj	apoptosis,inhibits
R7239	T11202	T11200	prep	through,inhibits
R7240	T11203	T11204	det	the,control
R7241	T11204	T11202	pobj	control,through
R7242	T11205	T11204	prep	of,control
R7243	T11206	T11207	amod	multiple,effectors
R7244	T11207	T11205	pobj	effectors,of
R7245	T11208	T11207	prep	including,effectors
R7246	T11209	T11208	pobj	mTORC1,including
R7247	T11210	T11209	punct	",",mTORC1
R7248	T11211	T11209	conj	GSK-3,mTORC1
R7249	T11212	T11211	cc	and,GSK-3
R7250	T11213	T11211	conj	others,GSK-3
R7251	T11214	T11216	nmod	[,]
R7252	T11215	T11216	nummod	28,]
R7253	T11216	T11213	appos	],others
R7254	T11217	T11193	punct	.,considered
R7255	T11218	T11220	det	An,question
R7256	T11219	T11220	amod	important,question
R7257	T11220	T11221	nsubj	question,is
R7258	T11221	T11221	ROOT	is,is
R7259	T11222	T11226	mark	whether,reverse
R7260	T11223	T11225	det	these,molecules
R7261	T11224	T11225	amod	same,molecules
R7262	T11225	T11226	nsubj	molecules,reverse
R7263	T11226	T11221	ccomp	reverse,is
R7264	T11227	T11229	poss	their,roles
R7265	T11228	T11229	amod	pro-survival,roles
R7266	T11229	T11226	dobj	roles,reverse
R7267	T11230	T11226	prep	during,reverse
R7268	T11231	T11230	pobj	necroptosis,during
R7269	T11232	T11221	punct	.,is
R7270	T11233	T11234	nsubj	We,found
R7271	T11234	T11234	ROOT	found,found
R7272	T11235	T11236	det	that,inhibition
R7273	T11236	T11234	dobj	inhibition,found
R7274	T11237	T11236	prep	of,inhibition
R7275	T11238	T11237	pobj	mTORC1,of
R7276	T11239	T11236	prep	by,inhibition
R7277	T11240	T11239	pobj	rapamycin,by
R7278	T11241	T11240	punct	",",rapamycin
R7279	T11242	T11243	det	an,inhibitor
R7280	T11243	T11236	conj	inhibitor,inhibition
R7281	T11244	T11243	prep	of,inhibitor
R7282	T11245	T11247	det	the,co-factor
R7283	T11246	T11247	compound	mTOR,co-factor
R7284	T11247	T11244	pobj	co-factor,of
R7285	T11248	T11249	compound	Raptor,[
R7286	T11249	T11247	appos	[,co-factor
R7287	T11250	T11251	nummod	29,]
R7288	T11251	T11247	appos	],co-factor
R7289	T11252	T11251	punct	",",]
R7290	T11253	T11254	amod	protected,cells
R7291	T11254	T11247	appos	cells,co-factor
R7294	T11257	T11256	punct	(,necroptosis
R7295	T11258	T11259	compound	Fig.,5C
R7296	T11259	T11256	appos	5C,necroptosis
R7297	T11260	T11256	punct	),necroptosis
R7298	T11261	T11234	punct	.,found
R7299	T11262	T11284	advmod	Similarly,inhibited
R7300	T11263	T11284	punct	",",inhibited
R7301	T11264	T11268	det	the,inhibitor
R7302	T11265	T11268	amod	direct,inhibitor
R7303	T11266	T11268	compound	mTOR,inhibitor
R7304	T11267	T11268	compound	kinase,inhibitor
R7305	T11268	T11284	nsubj	inhibitor,inhibited
R7306	T11269	T11270	compound	Torin1,[
R7307	T11270	T11268	appos	[,inhibitor
R7308	T11271	T11272	nummod	30,]
R7309	T11272	T11270	appos	],[
R7310	T11273	T11272	cc	and,]
R7311	T11274	T11277	det	the,inhibitor
R7312	T11275	T11277	amod	dual,inhibitor
R7313	T11276	T11277	amod	PI3K/mTOR,inhibitor
R7314	T11277	T11278	compound	inhibitor,PI-103
R7315	T11278	T11279	compound	PI-103,[
R7316	T11279	T11281	compound	[,]
R7317	T11280	T11281	compound	31,]
R7318	T11281	T11272	conj	],]
R7319	T11282	T11284	advmod	also,inhibited
R7320	T11283	T11284	advmod	efficiently,inhibited
R7321	T11284	T11284	ROOT	inhibited,inhibited
R7322	T11285	T11284	dobj	necroptosis,inhibited
R7323	T11286	T11288	punct	(,5C
R7324	T11287	T11288	compound	Fig.,5C
R7325	T11288	T11285	appos	5C,necroptosis
R7326	T11289	T11288	punct	),5C
R7327	T11290	T11284	punct	.,inhibited
R7328	T11291	T11297	nsubj	Knockdown,validated
R7329	T11292	T11291	prep	of,Knockdown
R7330	T11293	T11292	pobj	mTOR,of
R7331	T11294	T11297	nsubj	using,validated
R7332	T11295	T11296	compound	siRNA,further
R7333	T11296	T11297	advmod	further,validated
R7334	T11297	T11297	ROOT	validated,validated
R7335	T11298	T11301	det	the,data
R7336	T11299	T11301	amod	small-molecule,data
R7337	T11300	T11301	compound	inhibitor,data
R7338	T11301	T11297	dobj	data,validated
R7339	T11302	T11301	acl	indicating,data
R7340	T11303	T11304	det	a,role
R7341	T11304	T11302	dobj	role,indicating
R7342	T11305	T11304	prep	for,role
R7343	T11306	T11305	pobj	mTOR,for
R7344	T11307	T11304	prep	in,role
R7345	T11308	T11307	pobj	necroptosis,in
R7346	T11309	T11304	prep	by,role
R7347	T11310	T11309	pcomp	protecting,by
R7348	T11311	T11310	dobj	cells,protecting
R7349	T11312	T11310	prep	from,protecting
R7350	T11313	T11314	preconj	both,zVAD.fmk
R7351	T11314	T11312	pobj	zVAD.fmk,from
R7352	T11315	T11314	cc	and,zVAD.fmk
R7353	T11316	T11314	conj	TNFα,zVAD.fmk
R7354	T11317	T11297	conj	induced,validated
R7355	T11318	T11317	dobj	death,induced
R7356	T11319	T11321	punct	(,5D
R7357	T11320	T11321	compound	Fig.,5D
R7358	T11321	T11317	oprd	5D,induced
R7359	T11322	T11321	punct	),5D
R7360	T11323	T11297	punct	.,validated
R7361	T11324	T11325	nsubj	mTORC1,regulates
R7362	T11325	T11325	ROOT	regulates,regulates
R7363	T11326	T11325	dobj	translation,regulates
R7364	T11327	T11325	prep	through,regulates
R7365	T11328	T11327	pobj	activation,through
R7366	T11329	T11328	prep	of,activation
R7367	T11330	T11331	compound	p70S6,kinase
R7368	T11331	T11329	pobj	kinase,of
R7369	T11332	T11328	cc	and,activation
R7370	T11333	T11325	punct	",",regulates
R7371	T11334	T11325	advmod	subsequently,regulates
R7372	T11335	T11325	punct	",",regulates
R7373	T11336	T11337	amod	ribosomal,protein
R7374	T11337	T11341	compound	protein,]
R7375	T11338	T11339	compound	S6,[
R7376	T11339	T11339	ROOT	[,[
R7377	T11340	T11341	nummod	32,]
R7378	T11341	T11325	npadvmod	],regulates
R7379	T11342	T11325	punct	.,regulates
R7380	T11343	T11352	advmod	Notably,suggested
R7381	T11344	T11352	punct	",",suggested
R7382	T11345	T11348	det	a,screen
R7383	T11346	T11348	amod	genome-wide,screen
R7384	T11347	T11348	compound	siRNA,screen
R7385	T11348	T11352	nsubj	screen,suggested
R7386	T11349	T11351	nmod	[,]
R7387	T11350	T11351	nummod	10,]
R7388	T11351	T11352	nsubj	],suggested
R7389	T11352	T11352	ROOT	suggested,suggested
R7390	T11353	T11355	det	an,role
R7391	T11354	T11355	amod	important,role
R7392	T11355	T11352	dobj	role,suggested
R7393	T11356	T11355	prep	for,role
R7394	T11357	T11358	compound	protein,translation
R7395	T11358	T11356	pobj	translation,for
R7396	T11359	T11358	prep	in,translation
R7397	T11360	T11359	pobj	necroptosis,in
R7398	T11361	T11352	punct	.,suggested
R7399	T11362	T11365	advmod	Consistently,found
R7400	T11363	T11365	punct	",",found
R7401	T11364	T11365	nsubj	we,found
R7402	T11365	T11365	ROOT	found,found
R7403	T11366	T11377	mark	that,attenuated
R7404	T11367	T11370	det	the,inhibitor
R7405	T11368	T11370	amod	small,inhibitor
R7406	T11369	T11370	compound	molecule,inhibitor
R7407	T11370	T11377	nsubj	inhibitor,attenuated
R7408	T11371	T11370	prep	of,inhibitor
R7409	T11372	T11374	compound	p70S6K,[
R7410	T11373	T11374	compound	PF-4708671,[
R7411	T11374	T11371	pobj	[,of
R7412	T11375	T11376	nummod	33,]
R7413	T11376	T11370	appos	],inhibitor
R7414	T11377	T11365	ccomp	attenuated,found
R7415	T11378	T11377	dobj	necroptosis,attenuated
R7416	T11379	T11377	prep	at,attenuated
R7417	T11380	T11381	det	the,concentrations
R7418	T11381	T11379	pobj	concentrations,at
R7419	T11382	T11381	acl	required,concentrations
R7420	T11383	T11384	aux	to,block
R7421	T11384	T11382	xcomp	block,required
R7422	T11385	T11386	compound	S6,phosphorylation
R7423	T11386	T11384	dobj	phosphorylation,block
R7424	T11387	T11388	punct	(,Fig
R7425	T11388	T11386	appos	Fig,phosphorylation
R7426	T11389	T11365	punct	.,found
R7427	T11446	T11447	det	the,activity
R7428	T11390	T11390	ROOT	S5C,S5C
R7429	T11447	T11456	nsubj	activity,promote
R7430	T11391	T11392	punct	",",D
R7431	T11448	T11447	prep	of,activity
R7432	T11449	T11451	det	an,branch
R7433	T11392	T11390	appos	D,S5C
R7434	T11450	T11451	amod	anti-apoptotic,branch
R7435	T11451	T11448	pobj	branch,of
R7436	T11393	T11390	punct	),S5C
R7437	T11452	T11451	prep	of,branch
R7438	T11453	T11452	pobj	Akt,of
R7439	T11454	T11456	nsubj	signaling,promote
R7440	T11394	T11390	punct	.,S5C
R7441	T11455	T11456	aux	can,promote
R7442	T11456	T11444	acl	promote,evidence
R7443	T11395	T11397	amod	Partial,knockdown
R7444	T11457	T11456	dobj	necroptosis,promote
R7445	T11458	T11443	punct	.,provide
R7446	T11459	T11460	nummod	RIP1,kinase
R7447	T11396	T11397	compound	siRNA,knockdown
R7448	T11460	T11467	nsubj	kinase,control
R7449	T11461	T11460	punct	",",kinase
R7450	T11462	T11460	appos	Akt,kinase
R7451	T11397	T11401	nsubj	knockdown,attenuated
R7452	T11463	T11462	punct	",",Akt
R7453	T11464	T11462	conj	mTORC1,Akt
R7454	T11465	T11464	cc	and,mTORC1
R7455	T11398	T11397	prep	of,knockdown
R7456	T11466	T11464	conj	JNK,mTORC1
R7457	T11467	T11467	ROOT	control,control
R7458	T11468	T11469	det	the,upregulation
R7459	T11399	T11400	nummod	S6,protein
R7460	T11469	T11467	dobj	upregulation,control
R7461	T11470	T11469	prep	of,upregulation
R7462	T11400	T11398	pobj	protein,of
R7463	T11471	T11470	pobj	TNFα,of
R7464	T11472	T11473	amod	accompanying,necroptosis
R7465	T11473	T11467	dobj	necroptosis,control
R7466	T11474	T11467	punct	.,control
R7467	T11401	T11401	ROOT	attenuated,attenuated
R7468	T11475	T11478	compound	Hitomi,[
R7469	T11476	T11477	compound	et,al.
R7470	T11477	T11478	compound	al.,[
R7471	T11478	T11483	nsubj	[,reported
R7472	T11402	T11401	dobj	necroptosis,attenuated
R7473	T11479	T11480	nummod	10,]
R7474	T11480	T11483	nsubj	],reported
R7475	T11481	T11483	aux	have,reported
R7476	T11482	T11483	advmod	recently,reported
R7477	T11403	T11404	advmod	as,well
R7478	T11483	T11483	ROOT	reported,reported
R7479	T11484	T11495	mark	that,associated
R7480	T11404	T11401	advmod	well,attenuated
R7481	T11485	T11486	det	the,induction
R7482	T11486	T11495	nsubjpass	induction,associated
R7483	T11487	T11486	prep	of,induction
R7484	T11405	T11406	punct	(,Fig
R7485	T11488	T11487	pobj	necroptosis,of
R7486	T11489	T11486	prep	by,induction
R7487	T11490	T11489	pobj	zVAD.fmk,by
R7488	T11406	T11401	npadvmod	Fig,attenuated
R7489	T11491	T11486	prep	in,induction
R7490	T11492	T11493	compound	L929,cells
R7491	T11493	T11491	pobj	cells,in
R7492	T11407	T11401	punct	.,attenuated
R7493	T11494	T11495	auxpass	is,associated
R7494	T11495	T11483	ccomp	associated,reported
R7495	T11408	T11418	nsubj	S5E,play
R7496	T11496	T11495	prep	with,associated
R7497	T11497	T11498	amod	increased,synthesis
R7498	T11498	T11496	pobj	synthesis,with
R7499	T11409	T11408	punct	),S5E
R7500	T11499	T11498	prep	of,synthesis
R7501	T11500	T11499	pobj	TNFα,of
R7502	T11501	T11500	punct	",",TNFα
R7503	T11410	T11408	punct	",",S5E
R7504	T11411	T11408	acl	suggesting,S5E
R7505	T11412	T11414	det	that,control
R7506	T11502	T11503	nsubj	which,potentiates
R7507	T11503	T11500	relcl	potentiates,TNFα
R7509	T11504	T11505	compound	cell,death
R7510	T11505	T11503	dobj	death,potentiates
R7511	T11506	T11483	punct	.,reported
R7513	T11507	T11510	advmod	Therefore,examined
R7514	T11508	T11510	punct	",",examined
R7515	T11509	T11510	nsubj	we,examined
R7516	T11510	T11510	ROOT	examined,examined
R7517	T11511	T11516	mark	whether,contribute
R7518	T11512	T11516	nsubj	Akt,contribute
R7520	T11513	T11512	cc	and,Akt
R7521	T11514	T11515	poss	its,effectors
R7522	T11515	T11512	conj	effectors,Akt
R7523	T11516	T11510	ccomp	contribute,examined
R7525	T11517	T11516	prep	to,contribute
R7526	T11518	T11519	compound	TNFα,synthesis
R7527	T11519	T11517	pobj	synthesis,to
R7528	T11520	T11510	punct	.,examined
R7530	T11521	T11521	ROOT	Consistent,Consistent
R7531	T11522	T11521	prep	with,Consistent
R7532	T11523	T11525	det	a,increase
R7533	T11524	T11525	amod	RIP1-dependent,increase
R7535	T11525	T11522	pobj	increase,with
R7536	T11526	T11525	prep	in,increase
R7537	T11527	T11528	compound	TNFα,protein
R7538	T11528	T11526	pobj	protein,in
R7540	T11529	T11530	punct	(,Fig
R7541	T11530	T11528	appos	Fig,protein
R7542	T11420	T11418	dobj	role,play
R7543	T11531	T11521	punct	.,Consistent
R7545	T11532	T11534	nummod	S6A,B
R7546	T11533	T11534	punct	",",B
R7547	T11534	T11538	npadvmod	B,found
R7548	T11535	T11534	punct	),B
R7550	T11536	T11538	punct	",",found
R7551	T11537	T11538	nsubj	we,found
R7552	T11538	T11538	ROOT	found,found
R7553	T11423	T11418	punct	.,play
R7554	T11539	T11543	mark	that,increased
R7555	T11540	T11542	compound	TNFα,levels
R7556	T11541	T11542	compound	mRNA,levels
R7557	T11424	T11443	advmod	Overall,provide
R7558	T11542	T11543	nsubj	levels,increased
R7559	T11425	T11443	punct	",",provide
R7560	T11426	T11435	mark	while,remains
R7561	T11427	T11429	det	the,repertoire
R7562	T11428	T11429	amod	full,repertoire
R7563	T11543	T11538	ccomp	increased,found
R7564	T11544	T11543	prep	during,increased
R7565	T11545	T11544	pobj	necroptosis,during
R7566	T11546	T11543	prep	in,increased
R7567	T11547	T11548	nummod	L929,cells
R7568	T11548	T11546	pobj	cells,in
R7569	T11429	T11435	nsubj	repertoire,remains
R7570	T11549	T11543	prep	in,increased
R7571	T11550	T11551	det	a,RIP1
R7572	T11430	T11429	prep	of,repertoire
R7573	T11551	T11549	pobj	RIP1,in
R7574	T11552	T11553	punct	(,Fig
R7575	T11431	T11432	compound	Akt,targets
R7576	T11553	T11551	appos	Fig,RIP1
R7577	T11554	T11538	punct	.,found
R7578	T11555	T11555	ROOT	S6C,S6C
R7579	T11432	T11430	pobj	targets,of
R7580	T11556	T11555	punct	.,S6C
R7581	T11557	T11564	prep	Under,triggered
R7582	T11558	T11560	amod	serum,conditions
R7583	T11433	T11429	prep	during,repertoire
R7584	T11559	T11560	amod	free,conditions
R7585	T11560	T11557	pobj	conditions,Under
R7586	T11561	T11564	punct	",",triggered
R7587	T11434	T11433	pobj	necroptosis,during
R7588	T11562	T11564	nsubj	bFGF,triggered
R7589	T11563	T11564	advmod	alone,triggered
R7590	T11564	T11564	ROOT	triggered,triggered
R7591	T11435	T11443	advcl	remains,provide
R7592	T11565	T11566	det	some,induction
R7593	T11566	T11564	dobj	induction,triggered
R7594	T11567	T11566	prep	of,induction
R7595	T11436	T11439	aux	to,explored
R7596	T11568	T11569	compound	TNFα,mRNA
R7597	T11569	T11567	pobj	mRNA,of
R7598	T11570	T11564	punct	",",triggered
R7599	T11437	T11439	auxpass	be,explored
R7600	T11571	T11582	mark	while,caused
R7601	T11572	T11573	poss	its,combination
R7602	T11573	T11582	nsubj	combination,caused
R7603	T11438	T11439	advmod	fully,explored
R7604	T11574	T11573	prep	with,combination
R7605	T11575	T11574	pobj	zVAD.fmk,with
R7606	T11576	T11582	punct	(,caused
R7607	T11439	T11435	xcomp	explored,remains
R7608	T11577	T11582	cc	but,caused
R7609	T11578	T11582	neg	not,caused
R7610	T11440	T11443	punct	",",provide
R7611	T11579	T11582	nsubj	zVAD.fmk,caused
R7612	T11441	T11442	poss	our,data
R7613	T11442	T11443	nsubj	data,provide
R7614	T11580	T11579	advmod	alone,zVAD.fmk
R7615	T11581	T11579	punct	),zVAD.fmk
R7616	T11582	T11564	advcl	caused,triggered
R7617	T11583	T11586	det	a,increase
R7618	T11584	T11586	amod	pronounced,increase
R7619	T11443	T11443	ROOT	provide,provide
R7620	T11585	T11586	amod	further,increase
R7621	T11586	T11582	dobj	increase,caused
R7622	T11587	T11589	punct	(,6A
R7623	T11444	T11443	dobj	evidence,provide
R7624	T11588	T11589	compound	Fig.,6A
R7625	T11445	T11456	mark	that,promote
R7626	T11589	T11586	appos	6A,increase
R7627	T11590	T11589	punct	),6A
R7628	T11591	T11564	punct	.,triggered
R7629	T11640	T11643	nsubj	Akt,contribute
R7630	T11592	T11595	advmod	Conversely,caused
R7631	T11593	T11595	punct	",",caused
R7632	T11594	T11595	nsubj	PDGF,caused
R7633	T11641	T11640	cc	and,Akt
R7634	T11595	T11595	ROOT	caused,caused
R7635	T11596	T11598	det	a,upregulation
R7636	T11597	T11598	amod	modest,upregulation
R7637	T11642	T11640	conj	mTORC1,Akt
R7638	T11598	T11595	dobj	upregulation,caused
R7639	T11599	T11598	prep	of,upregulation
R7640	T11643	T11637	ccomp	contribute,suggested
R7641	T11600	T11601	compound	TNFα,mRNA
R7642	T11601	T11599	pobj	mRNA,of
R7643	T11602	T11601	punct	",",mRNA
R7644	T11644	T11643	prep	to,contribute
R7645	T11603	T11604	nsubj	which,was
R7646	T11604	T11598	relcl	was,upregulation
R7647	T11605	T11607	neg	not,increased
R7648	T11645	T11646	det	the,upregulation
R7649	T11606	T11607	advmod	further,increased
R7650	T11607	T11595	conj	increased,caused
R7651	T11608	T11607	prep	in,increased
R7652	T11646	T11644	pobj	upregulation,to
R7653	T11609	T11610	det	the,presence
R7654	T11610	T11608	pobj	presence,in
R7655	T11611	T11610	prep	of,presence
R7656	T11612	T11611	pobj	zVAD.fmk,of
R7657	T11647	T11646	prep	of,upregulation
R7658	T11613	T11615	punct	(,6A
R7659	T11614	T11615	compound	Fig.,6A
R7660	T11648	T11649	compound	TNFα,mRNA
R7661	T11615	T11612	appos	6A,zVAD.fmk
R7662	T11616	T11615	punct	),6A
R7663	T11617	T11607	punct	",",increased
R7664	T11649	T11647	pobj	mRNA,of
R7665	T11618	T11607	advcl	demonstrating,increased
R7666	T11619	T11625	mark	that,accompanied
R7667	T11620	T11625	nsubjpass	activation,accompanied
R7668	T11621	T11620	prep	of,activation
R7669	T11622	T11621	pobj	necroptosis,of
R7670	T11623	T11625	auxpass	is,accompanied
R7671	T11650	T11643	prep	during,contribute
R7672	T11624	T11625	advmod	specifically,accompanied
R7673	T11625	T11618	ccomp	accompanied,demonstrating
R7674	T11626	T11625	agent	by,accompanied
R7675	T11651	T11650	pobj	necroptosis,during
R7676	T11627	T11629	det	a,increase
R7677	T11628	T11629	amod	marked,increase
R7678	T11652	T11663	mark	as,reduced
R7679	T11629	T11626	pobj	increase,by
R7680	T11630	T11629	prep	in,increase
R7681	T11631	T11632	compound	autocrine,TNFα
R7682	T11653	T11655	det	both,inhibition
R7683	T11632	T11633	compound	TNFα,synthesis
R7684	T11633	T11630	pobj	synthesis,in
R7685	T11634	T11607	punct	.,increased
R7686	T11654	T11655	amod	small-molecule,inhibition
R7687	T11635	T11636	amod	Further,analysis
R7688	T11636	T11637	nsubj	analysis,suggested
R7689	T11637	T11637	ROOT	suggested,suggested
R7690	T11655	T11652	pobj	inhibition,as
R7691	T11638	T11643	mark	that,contribute
R7692	T11639	T11640	preconj	both,Akt
R7693	T11656	T11655	cc	and,inhibition
R7694	T11657	T11655	conj	siRNA,inhibition
R7696	T11659	T11658	prep	of,knockdown
R7697	T11660	T11659	pobj	Akt,of
R7698	T11661	T11660	cc	and,Akt
R7699	T11662	T11660	conj	mTOR,Akt
R7700	T11663	T11643	advcl	reduced,contribute
R7701	T11664	T11665	compound	TNFα,mRNA
R7702	T11665	T11666	compound	mRNA,levels
R7703	T11666	T11663	dobj	levels,reduced
R7704	T11667	T11663	prep	in,reduced
R7705	T11668	T11669	amod	necroptotic,cells
R7706	T11669	T11667	pobj	cells,in
R7707	T11670	T11672	punct	(,6B
R7708	T11671	T11672	compound	Fig.,6B
R7709	T11672	T11643	npadvmod	6B,contribute
R7710	T11673	T11672	punct	",",6B
R7711	T11674	T11672	conj	C,6B
R7712	T11675	T11674	punct	",",C
R7713	T11676	T11674	conj	D,C
R7714	T11677	T11672	punct	),6B
R7715	T11678	T11637	punct	.,suggested
R7716	T11679	T11685	advmod	Notably,had
R7717	T11680	T11685	punct	",",had
R7718	T11681	T11684	nmod	RIP1,inhibitors
R7719	T11682	T11681	cc	and,RIP1
R7720	T11683	T11681	conj	Akt,RIP1
R7721	T11684	T11685	nsubj	inhibitors,had
R7722	T11685	T11685	ROOT	had,had
R7723	T11686	T11687	det	no,effect
R7724	T11687	T11685	dobj	effect,had
R7725	T11688	T11687	prep	on,effect
R7726	T11689	T11690	det	the,levels
R7727	T11690	T11688	pobj	levels,on
R7728	T11691	T11690	prep	of,levels
R7729	T11692	T11693	compound	TNFα,mRNA
R7730	T11693	T11691	pobj	mRNA,of
R7731	T11694	T11690	prep	in,levels
R7732	T11695	T11696	compound	control,cells
R7733	T11696	T11694	pobj	cells,in
R7734	T11697	T11694	cc	or,in
R7735	T11698	T11694	conj	in,in
R7736	T11699	T11700	det	the,cells
R7737	T11700	T11698	pobj	cells,in
R7738	T11701	T11700	acl	stimulated,cells
R7739	T11702	T11701	prep	with,stimulated
R7740	T11703	T11702	pobj	bFGF,with
R7741	T11704	T11703	advmod	alone,bFGF
R7742	T11705	T11707	punct	(,6A
R7743	T11706	T11707	compound	Fig.,6A
R7744	T11707	T11703	appos	6A,bFGF
R7745	T11708	T11707	punct	",",6A
R7746	T11709	T11707	conj	B,6A
R7747	T11710	T11709	punct	",",B
R7748	T11711	T11709	conj	Fig,B
R7749	T11712	T11685	punct	.,had
R7750	T11713	T11713	ROOT	S6C,S6C
R7751	T11714	T11713	punct	),S6C
R7752	T11715	T11713	punct	",",S6C
R7753	T11716	T11713	acl	suggesting,S6C
R7754	T11717	T11721	mark	that,mediate
R7755	T11718	T11719	det	these,kinases
R7756	T11719	T11721	nsubj	kinases,mediate
R7757	T11720	T11721	advmod	specifically,mediate
R7758	T11721	T11716	ccomp	mediate,suggesting
R7759	T11722	T11723	amod	necroptosis-dependent,increase
R7760	T11723	T11721	dobj	increase,mediate
R7761	T11724	T11723	prep	in,increase
R7762	T11725	T11726	compound	TNFα,synthesis
R7763	T11726	T11724	pobj	synthesis,in
R7764	T11727	T11713	punct	.,S6C
R21059	T30401	T30402	nsubj	mTORC1,contributes
R21060	T30402	T30402	ROOT	contributes,contributes
R21061	T30403	T30402	prep	to,contributes
R21062	T30404	T30405	det	the,regulation
R21063	T30405	T30403	pobj	regulation,to
R21064	T30406	T30405	prep	of,regulation
R21065	T30407	T30406	pobj	necroptosis,of
R21066	T30408	T30402	punct	.,contributes
R21067	T30409	T30415	punct	(,treated
R21068	T30410	T30413	nmod	A,cells
R21069	T30411	T30410	punct	),A
R21070	T30412	T30413	compound	L929,cells
R21071	T30413	T30415	nsubjpass	cells,treated
R21072	T30414	T30415	auxpass	were,treated
R21073	T30415	T30415	ROOT	treated,treated
R21074	T30416	T30415	prep	with,treated
R21075	T30417	T30416	pobj	zVAD.fmk,with
R21076	T30418	T30417	cc	or,zVAD.fmk
R21077	T30419	T30417	conj	TNFα,zVAD.fmk
R21078	T30420	T30415	prep	for,treated
R21079	T30421	T30422	nummod	9,hr
R21080	T30422	T30420	pobj	hr,for
R21081	T30423	T30415	cc	and,treated
R21082	T30424	T30415	conj	harvested,treated
R21083	T30425	T30424	prep	for,harvested
R21084	T30426	T30427	amod	western,blot
R21085	T30427	T30425	pobj	blot,for
R21086	T30428	T30415	punct	.,treated
R21087	T30429	T30432	punct	(,Cell
R21088	T30430	T30432	nmod	B,Cell
R21089	T30431	T30432	punct	),Cell
R21090	T30432	T30438	nsubjpass	Cell,treated
R21091	T30433	T30432	prep	under,Cell
R21092	T30434	T30436	amod	serum,condition
R21093	T30435	T30436	amod	free,condition
R21094	T30436	T30433	pobj	condition,under
R21095	T30437	T30438	auxpass	were,treated
R21096	T30438	T30438	ROOT	treated,treated
R21097	T30439	T30438	prep	with,treated
R21098	T30440	T30439	pobj	bFGF,with
R21099	T30441	T30440	cc	or,bFGF
R21100	T30442	T30440	conj	bFGF/zVAD,bFGF
R21101	T30443	T30438	punct	.,treated
R21102	T30444	T30444	ROOT	fmk,fmk
R21103	T30445	T30444	prep	for,fmk
R21104	T30446	T30448	det	the,amounts
R21105	T30447	T30448	amod	indicated,amounts
R21106	T30448	T30445	pobj	amounts,for
R21107	T30449	T30448	prep	of,amounts
R21108	T30450	T30449	pobj	time,of
R21109	T30451	T30444	punct	",",fmk
R21110	T30452	T30444	acl	followed,fmk
R21111	T30453	T30452	agent	by,followed
R21112	T30454	T30455	amod	western,blotting
R21113	T30455	T30453	pobj	blotting,by
R21114	T30456	T30452	advcl	using,followed
R21115	T30457	T30459	det	the,antibodies
R21116	T30458	T30459	amod	indicated,antibodies
R21117	T30459	T30456	dobj	antibodies,using
R21118	T30460	T30444	punct	.,fmk
R21119	T30461	T30464	punct	(,Necroptosis
R21120	T30462	T30464	nmod	C,Necroptosis
R21121	T30463	T30464	punct	),Necroptosis
R21122	T30464	T30466	nsubjpass	Necroptosis,induced
R21123	T30465	T30466	auxpass	was,induced
R21124	T30466	T30466	ROOT	induced,induced
R21125	T30467	T30466	agent	by,induced
R21126	T30468	T30467	pobj	zVAD.fmk,by
R21127	T30469	T30468	cc	or,zVAD.fmk
R21128	T30470	T30468	conj	TNFα,zVAD.fmk
R21129	T30471	T30466	prep	in,induced
R21130	T30472	T30473	compound	L929,cell
R21131	T30473	T30471	pobj	cell,in
R21132	T30474	T30473	prep	in,cell
R21133	T30475	T30476	det	the,presence
R21134	T30476	T30474	pobj	presence,in
R21135	T30477	T30476	prep	of,presence
R21136	T30478	T30477	pobj	inhibitors,of
R21137	T30479	T30478	prep	of,inhibitors
R21138	T30480	T30479	pobj	Akt,of
R21139	T30481	T30483	punct	(,inh
R21140	T30482	T30483	compound	Akt,inh
R21141	T30483	T30480	appos	inh,Akt
R21142	T30484	T30466	punct	.,induced
R21143	T30485	T30485	ROOT	VIII,VIII
R21144	T30486	T30485	punct	),VIII
R21145	T30487	T30485	cc	and,VIII
R21146	T30488	T30485	conj	mTOR,VIII
R21147	T30489	T30490	punct	(,rapamycin
R21148	T30490	T30485	appos	rapamycin,VIII
R21149	T30491	T30490	punct	",",rapamycin
R21150	T30492	T30490	conj	Torin-1,rapamycin
R21151	T30493	T30492	cc	and,Torin-1
R21152	T30494	T30492	conj	PI-103,Torin-1
R21153	T30495	T30492	punct	),Torin-1
R21154	T30496	T30485	punct	.,VIII
R21155	T30497	T30501	punct	(,cells
R21156	T30498	T30501	compound	D,cells
R21157	T30499	T30500	punct	),L929
R21158	T30500	T30501	compound	L929,cells
R21159	T30501	T30507	nsubjpass	cells,harvested
R21160	T30502	T30501	prep	with,cells
R21161	T30503	T30505	compound	mTOR,knockdown
R21162	T30504	T30505	compound	siRNA,knockdown
R21163	T30505	T30502	pobj	knockdown,with
R21164	T30506	T30507	auxpass	were,harvested
R21165	T30507	T30507	ROOT	harvested,harvested
R21166	T30508	T30507	prep	for,harvested
R21167	T30509	T30510	amod	western,blot
R21168	T30510	T30508	pobj	blot,for
R21169	T30511	T30507	cc	or,harvested
R21170	T30512	T30507	conj	treated,harvested
R21171	T30513	T30512	prep	with,treated
R21172	T30514	T30513	pobj	zVAD.fmk,with
R21173	T30515	T30514	cc	or,zVAD.fmk
R21174	T30516	T30514	conj	TNFα,zVAD.fmk
R21175	T30517	T30512	prep	for,treated
R21176	T30518	T30519	nummod	24,hrs
R21177	T30519	T30517	pobj	hrs,for
R21178	T30520	T30507	punct	.,harvested
R21179	T30521	T30522	compound	Cell,viability
R21180	T30522	T30524	nsubjpass	viability,determined
R21181	T30523	T30524	auxpass	was,determined
R21182	T30524	T30524	ROOT	determined,determined
R21183	T30525	T30526	nummod	24,hr
R21184	T30526	T30527	npadvmod	hr,after
R21185	T30527	T30524	prep	after,determined
R21186	T30528	T30527	pobj	activation,after
R21187	T30529	T30528	prep	of,activation
R21188	T30530	T30529	pobj	necroptosis,of
R21189	T30531	T30524	punct	.,determined
R21190	T30532	T30540	prep	In,plotted
R21191	T30533	T30534	det	all,graphs
R21192	T30534	T30532	pobj	graphs,In
R21193	T30535	T30540	punct	",",plotted
R21194	T30536	T30537	amod	average,±
R21195	T30537	T30538	compound	±,SD
R21196	T30538	T30540	nsubjpass	SD,plotted
R21197	T30539	T30540	auxpass	was,plotted
R21198	T30540	T30540	ROOT	plotted,plotted
R21199	T30541	T30540	punct	.,plotted
R21376	T30942	T30942	ROOT	Akt,Akt
R21377	T30943	T30942	cc	and,Akt
R21378	T30944	T30942	conj	mTORC1,Akt
R21379	T30945	T30948	nmod	control,synthesis
R21380	T30946	T30948	compound	autocrine,synthesis
R21381	T30947	T30948	compound	TNFα,synthesis
R21382	T30948	T30942	appos	synthesis,Akt
R21383	T30949	T30948	cc	and,synthesis
R21384	T30950	T30951	compound	JNK,activation
R21385	T30951	T30948	conj	activation,synthesis
R21386	T30952	T30951	prep	during,activation
R21387	T30953	T30952	pobj	necroptosis,during
R21388	T30954	T30942	punct	.,Akt
R21389	T30955	T30960	punct	(,treated
R21390	T30956	T30958	det	A,Cells
R21391	T30957	T30958	punct	),Cells
R21392	T30958	T30960	nsubjpass	Cells,treated
R21393	T30959	T30960	auxpass	were,treated
R21394	T30960	T30960	ROOT	treated,treated
R21395	T30961	T30960	prep	under,treated
R21396	T30962	T30963	npadvmod	serum,free
R21397	T30963	T30964	amod	free,conditions
R21398	T30964	T30961	pobj	conditions,under
R21399	T30965	T30960	prep	with,treated
R21400	T30966	T30965	pobj	bFGF,with
R21401	T30967	T30966	cc	or,bFGF
R21402	T30968	T30966	conj	PDGF,bFGF
R21403	T30969	T30965	conj	with,with
R21404	T30970	T30969	cc	or,with
R21405	T30971	T30969	conj	without,with
R21406	T30972	T30971	pobj	zVAD.fmk,without
R21407	T30973	T30960	prep	for,treated
R21408	T30974	T30975	nummod	9,hr
R21409	T30975	T30973	pobj	hr,for
R21410	T30976	T30960	punct	",",treated
R21411	T30977	T30960	advcl	followed,treated
R21412	T30978	T30977	agent	by,followed
R21413	T30979	T30980	amod	qRT-PCR,analysis
R21414	T30980	T30978	pobj	analysis,by
R21415	T30981	T30980	prep	of,analysis
R21416	T30982	T30981	pobj	mTNFα,of
R21417	T30983	T30960	punct	.,treated
R21418	T30984	T30985	nsubj	Data,was
R21419	T30985	T30985	ROOT	was,was
R21420	T30986	T30985	acomp	normalized,was
R21421	T30987	T30988	aux	to,mouse
R21422	T30988	T30986	xcomp	mouse,normalized
R21423	T30989	T30990	nummod	18S,RNA
R21424	T30990	T30988	dobj	RNA,mouse
R21425	T30991	T30985	punct	.,was
R21426	T30992	T30995	punct	(,Necroptosis
R21427	T30993	T30995	nmod	B,Necroptosis
R21428	T30994	T30995	punct	),Necroptosis
R21429	T30995	T30997	nsubjpass	Necroptosis,induced
R21430	T30996	T30997	auxpass	was,induced
R21431	T30997	T30997	ROOT	induced,induced
R21432	T30998	T30997	agent	by,induced
R21433	T30999	T30998	pobj	zVAD.fmk,by
R21434	T31000	T30999	cc	or,zVAD.fmk
R21435	T31001	T30999	conj	TNFα,zVAD.fmk
R21436	T31002	T30997	prep	in,induced
R21437	T31003	T31002	pobj	cells,in
R21438	T31004	T31003	acl	treated,cells
R21439	T31005	T31004	prep	with,treated
R21440	T31006	T31005	pobj	Nec-1,with
R21441	T31007	T30997	punct	",",induced
R21442	T31008	T30997	npadvmod	rapamycin,induced
R21443	T31009	T31010	punct	(,rapa
R21444	T31010	T31008	appos	rapa,rapamycin
R21445	T31011	T31010	punct	),rapa
R21446	T31012	T31010	punct	",",rapa
R21447	T31013	T31008	cc	or,rapamycin
R21448	T31014	T31015	compound	Akt,inh
R21458	T31024	T31023	prep	of,analysis
R21459	T31025	T31026	compound	TNFα,mRNA
R21460	T31026	T31027	compound	mRNA,levels
R21461	T31027	T31024	pobj	levels,of
R21462	T31028	T31020	punct	.,followed
R21463	T31029	T31030	punct	(,C-F
R21464	T31030	T31030	ROOT	C-F,C-F
R21465	T31031	T31030	punct	),C-F
R21466	T31032	T31033	nummod	L929,cells
R21467	T31033	T31053	nsubjpass	cells,stimulated
R21468	T31034	T31033	prep	with,cells
R21469	T31035	T31036	compound	siRNA,knockdown
R21470	T31036	T31034	pobj	knockdown,with
R21471	T31037	T31036	prep	of,knockdown
R21472	T31038	T31039	compound	Akt,isoforms
R21473	T31039	T31037	pobj	isoforms,of
R21474	T31040	T31041	punct	(,C
R21475	T31041	T31053	nsubjpass	C,stimulated
R21476	T31042	T31041	punct	",",C
R21477	T31043	T31041	appos	E,C
R21478	T31044	T31041	punct	),C
R21479	T31045	T31041	cc	or,C
R21480	T31046	T31041	conj	mTOR,C
R21481	T31047	T31048	punct	(,D
R21482	T31048	T31046	appos	D,mTOR
R21483	T31049	T31046	punct	",",mTOR
R21484	T31050	T31046	appos	F,mTOR
R21485	T31051	T31046	punct	),mTOR
R21486	T31052	T31053	auxpass	were,stimulated
R21487	T31053	T31053	ROOT	stimulated,stimulated
R21488	T31054	T31053	prep	with,stimulated
R21489	T31055	T31054	pobj	zVAD.fmk,with
R21490	T31056	T31055	cc	or,zVAD.fmk
R21491	T31057	T31055	conj	TNFα,zVAD.fmk
R21492	T31058	T31053	prep	for,stimulated
R21493	T31059	T31060	nummod	9,hr
R21494	T31060	T31058	pobj	hr,for
R21495	T31061	T31053	punct	",",stimulated
R21496	T31062	T31053	advcl	followed,stimulated
R21497	T31063	T31062	agent	by,followed
R21498	T31064	T31065	amod	qRT-PCR,analysis
R21499	T31065	T31063	pobj	analysis,by
R21500	T31066	T31065	prep	of,analysis
R21501	T31067	T31075	nmod	mTNFα,blot
R21502	T31068	T31069	punct	(,C
R21503	T31069	T31067	appos	C,mTNFα
R21504	T31070	T31069	punct	",",C
R21505	T31071	T31069	appos	D,C
R21506	T31072	T31069	punct	),C
R21507	T31073	T31069	cc	or,C
R21508	T31074	T31075	amod	western,blot
R21509	T31075	T31066	pobj	blot,of
R21510	T31076	T31077	punct	(,E
R21511	T31077	T31079	dep	E,F
R21512	T31078	T31079	punct	",",F
R21513	T31079	T31065	conj	F,analysis
R21514	T31080	T31079	punct	),F
R21515	T31081	T31053	punct	.,stimulated
R21516	T31082	T31090	prep	In,plotted
R21517	T31083	T31084	det	all,graphs
R21518	T31084	T31082	pobj	graphs,In
R21519	T31085	T31090	punct	",",plotted
R21520	T31086	T31087	amod	average,±
R21521	T31087	T31088	compound	±,SD
R21522	T31088	T31090	nsubjpass	SD,plotted
R21523	T31089	T31090	auxpass	was,plotted
R21524	T31090	T31090	ROOT	plotted,plotted
R21525	T31091	T31090	punct	.,plotted
R21449	T31015	T31008	conj	inh,rapamycin
R21450	T31016	T30997	punct	.,induced
R21451	T31017	T31018	compound	VIII,inh
R21452	T31018	T31018	ROOT	inh,inh
R21453	T31019	T31018	punct	.,inh
R21454	T31020	T31020	ROOT	followed,followed
R21455	T31021	T31020	agent	by,followed
R21456	T31022	T31023	amod	qRT-PCR,analysis
R21457	T31023	T31021	pobj	analysis,by
R7512	T11414	T11411	dobj	control,suggesting
R7519	T11415	T11414	prep	by,control
R7524	T11416	T11415	pobj	p70S6K/S6,by
R7529	T11417	T11418	aux	may,play
R7534	T11418	T11418	ROOT	play,play
R7539	T11419	T11420	det	a,role
R7544	T11421	T11420	prep	in,role
R7292	T11255	T11254	prep	from,cells
R7293	T11256	T11255	pobj	necroptosis,from
R7549	T11422	T11421	pobj	necroptosis,in
R7695	T11658	T11655	conj	knockdown,inhibition
R6977	T10940	T10943	det	The,Pathway
R7134	T11097	T11096	pobj	pFoxO1,of
R7508	T11413	T11414	amod	translational,control

bionlp-st-ge-2016-test-tees

Id	Subject	Object	Predicate	Lexical cue
T30925	4610-4617	Regulation	denotes	control
T30924	4610-4617	Regulation	denotes	control
T30923	4610-4617	Regulation	denotes	control
T30922	4651-4661	Positive_regulation	denotes	activation
T30921	4651-4661	Positive_regulation	denotes	activation
T30920	4633-4642	Gene_expression	denotes	synthesis
T30919	4647-4650	Protein	denotes	JNK
T30918	4628-4632	Protein	denotes	TNFα
T30917	4603-4609	Protein	denotes	mTORC1
T30916	4595-4598	Protein	denotes	Akt
T30589	1858-1867	Negative_regulation	denotes	knockdown
T30575	1356-1362	Protein	denotes	mTORC1
T10624	4149-4158	Negative_regulation	denotes	triggered
T10623	4164-4173	Positive_regulation	denotes	induction
T10622	4233-4241	Protein	denotes	zVAD.fmk
T10621	4215-4223	Protein	denotes	zVAD.fmk
T10620	4177-4186	Protein	denotes	TNFα mRNA
T10619	4138-4142	Protein	denotes	bFGF
T10618	4104-4107	Protein	denotes	S6C
T10617	4045-4054	Positive_regulation	denotes	increased
T10616	4045-4054	Positive_regulation	denotes	increased
T10615	3974-3982	Positive_regulation	denotes	increase
T10614	3974-3982	Positive_regulation	denotes	increase
T10613	4099-4102	Protein	denotes	Fig
T10612	4093-4097	Protein	denotes	RIP1
T10611	4028-4037	Protein	denotes	TNFα mRNA
T10610	4005-4008	Protein	denotes	S6A
T10609	4000-4003	Protein	denotes	Fig
T10608	3986-3998	Protein	denotes	TNFα protein
T10607	3959-3963	Protein	denotes	RIP1
T10606	3930-3939	Gene_expression	denotes	synthesis
T10605	3925-3929	Protein	denotes	TNFα
T10604	3809-3818	Gene_expression	denotes	synthesis
T10603	3822-3826	Protein	denotes	TNFα
T10602	3619-3626	Regulation	denotes	control
T10601	3619-3626	Regulation	denotes	control
T10600	3619-3626	Regulation	denotes	control
T10599	3619-3626	Regulation	denotes	control
T10598	3631-3643	Positive_regulation	denotes	upregulation
T10597	3647-3651	Protein	denotes	TNFα
T10596	3615-3618	Protein	denotes	JNK
T10595	3604-3610	Protein	denotes	mTORC1
T10594	3599-3602	Protein	denotes	Akt
T10593	3586-3597	Protein	denotes	RIP1 kinase
T10592	3547-3550	Protein	denotes	Akt
T10591	3223-3232	Negative_regulation	denotes	knockdown
T10590	3338-3340	Protein	denotes	S6
T10589	3331-3337	Protein	denotes	p70S6K
T10588	3236-3238	Protein	denotes	S6
T10587	3169-3174	Negative_regulation	denotes	block
T10586	3178-3193	Phosphorylation	denotes	phosphorylation
T10585	3175-3177	Protein	denotes	S6
T10584	2817-2826	Regulation	denotes	regulates
T10583	2847-2857	Positive_regulation	denotes	activation
T10582	2861-2873	Protein	denotes	p70S6 kinase
T10581	2810-2816	Protein	denotes	mTORC1
T10580	2613-2622	Negative_regulation	denotes	Knockdown
T10579	2780-2784	Protein	denotes	TNFα
T10578	2767-2775	Protein	denotes	zVAD.fmk
T10577	2717-2721	Protein	denotes	mTOR
T10576	2626-2642	Protein	denotes	mTOR using siRNA
T10575	2541-2550	Negative_regulation	denotes	inhibitor
T10574	2541-2550	Negative_regulation	denotes	inhibitor
T10573	2496-2505	Negative_regulation	denotes	inhibitor
T10572	2536-2540	Protein	denotes	mTOR
T10571	2531-2535	Protein	denotes	PI3K
T10570	2484-2495	Protein	denotes	mTOR kinase
T10569	2373-2382	Negative_regulation	denotes	inhibitor
T10568	2335-2345	Negative_regulation	denotes	inhibition
T10567	2390-2394	Protein	denotes	mTOR
T10566	2349-2355	Protein	denotes	mTORC1
T10565	2053-2063	Protein	denotes	Akt kinase
T10564	1288-1292	Protein	denotes	RIP1
T10563	1209-1212	Protein	denotes	Akt
T10562	1093-1102	Negative_regulation	denotes	abrogated
T10561	1093-1102	Negative_regulation	denotes	abrogated
T10560	1060-1069	Positive_regulation	denotes	increases
T10559	1127-1130	Protein	denotes	S5A
T10558	1122-1125	Protein	denotes	Fig
T10661	5734-5742	Positive_regulation	denotes	increase
T10660	5751-5760	Gene_expression	denotes	synthesis
T10659	5544-5550	Regulation	denotes	effect
T10658	5544-5550	Regulation	denotes	effect
T10657	5526-5536	Negative_regulation	denotes	inhibitors
T10656	5526-5536	Negative_regulation	denotes	inhibitors
T10655	5746-5750	Protein	denotes	TNFα
T10654	5627-5631	Protein	denotes	bFGF
T10653	5568-5577	Protein	denotes	TNFα mRNA
T10652	5522-5525	Protein	denotes	Akt
T10651	5513-5517	Protein	denotes	RIP1
T10650	5411-5416	Negative_regulation	denotes	siRNA
T10649	5411-5416	Negative_regulation	denotes	siRNA
T10648	5396-5406	Negative_regulation	denotes	inhibition
T10647	5396-5406	Negative_regulation	denotes	inhibition
T10646	5310-5320	Positive_regulation	denotes	contribute
T10645	5310-5320	Positive_regulation	denotes	contribute
T10644	5461-5467	Positive_regulation	denotes	levels
T10643	5417-5426	Negative_regulation	denotes	knockdown
T10642	5417-5426	Negative_regulation	denotes	knockdown
T10641	5411-5416	Negative_regulation	denotes	siRNA
T10640	5328-5340	Positive_regulation	denotes	upregulation
T10639	5438-5460	Protein	denotes	mTOR reduced TNFα mRNA
T10638	5430-5433	Protein	denotes	Akt
T10637	5344-5353	Protein	denotes	TNFα mRNA
T10636	5303-5309	Protein	denotes	mTORC1
T10635	5295-5298	Protein	denotes	Akt
T10634	4513-4521	Positive_regulation	denotes	increase
T10633	4314-4320	Positive_regulation	denotes	caused
T10632	4540-4549	Gene_expression	denotes	synthesis
T10631	4379-4388	Positive_regulation	denotes	increased
T10630	4330-4342	Positive_regulation	denotes	upregulation
T10629	4525-4539	Protein	denotes	autocrine TNFα
T10628	4418-4425	Protein	denotes	Fig. 6A
T10627	4408-4416	Protein	denotes	zVAD.fmk
T10626	4346-4355	Protein	denotes	TNFα mRNA
T10625	4309-4313	Protein	denotes	PDGF
T30579	1572-1575	Protein	denotes	fmk
T30578	1562-1571	Protein	denotes	bFGF/zVAD
T30588	1916-1932	Protein	denotes	zVAD.fmk or TNFα
T30587	1847-1857	Protein	denotes	mTOR siRNA
T30586	1752-1762	Negative_regulation	denotes	inhibitors
T30585	1752-1762	Negative_regulation	denotes	inhibitors
T30584	1752-1762	Negative_regulation	denotes	inhibitors
T30583	1789-1793	Protein	denotes	mTOR
T30582	1770-1773	Protein	denotes	Akt
T30581	1766-1769	Protein	denotes	Akt
T30580	1703-1719	Protein	denotes	zVAD.fmk or TNFα
T30577	1554-1558	Protein	denotes	bFGF
T30576	1442-1458	Protein	denotes	zVAD.fmk or TNFα
T10537	374-395	Protein	denotes	mouse double minute 2
T10536	356-369	Protein	denotes	GSK-3 kinases
T10535	318-354	Protein	denotes	Forkhead box class O (FoxO) proteins
T10534	302-305	Protein	denotes	Akt
T10533	174-182	Positive_regulation	denotes	increase
T10532	186-196	Protein	denotes	Akt kinase
T10531	4-7	Protein	denotes	Akt
T10557	1113-1120	Protein	denotes	Fig. 5A
T10556	1106-1111	Protein	denotes	Nec-1
T10555	1073-1076	Protein	denotes	Akt
T10554	727-735	Positive_regulation	denotes	increase
T10553	743-758	Phosphorylation	denotes	phosphorylation
T10552	688-703	Phosphorylation	denotes	phosphorylation
T10551	688-703	Phosphorylation	denotes	phosphorylation
T10550	769-772	Protein	denotes	S5A
T10549	760-767	Protein	denotes	Fig. 5B
T10548	739-742	Protein	denotes	Akt
T10547	586-602	Protein	denotes	GSK-3α/β, p70S6K
T10546	578-584	Protein	denotes	FoxO3a
T10545	539-547	Positive_regulation	denotes	increase
T10544	523-527	Protein	denotes	MDM2
T10543	516-521	Protein	denotes	FoxO4
T10542	509-514	Protein	denotes	FoxO1
T10541	470-476	Protein	denotes	p70S6K
T10540	459-468	Protein	denotes	S6 Kinase
T10539	437-458	Protein	denotes	p70 ribosomal protein
T10538	397-401	Protein	denotes	MDM2
T30941	5058-5067	Negative_regulation	denotes	knockdown
T30940	5137-5141	Protein	denotes	TNFα
T30939	5125-5133	Protein	denotes	zVAD.fmk
T30938	5071-5074	Protein	denotes	Akt
T30937	5012-5021	Protein	denotes	TNFα mRNA
T30936	4975-4978	Protein	denotes	inh
T30935	4961-4968	Protein	denotes	Akt inh
T30934	4933-4938	Protein	denotes	Nec-1
T30933	4906-4910	Protein	denotes	TNFα
T30932	4894-4902	Protein	denotes	zVAD.fmk
T30931	4848-4861	Protein	denotes	mouse 18S RNA
T30930	4818-4823	Protein	denotes	mTNFα
T30929	4746-4750	Protein	denotes	PDGF
T30928	4738-4742	Protein	denotes	bFGF
T30927	4610-4617	Regulation	denotes	control
T30926	4610-4617	Regulation	denotes	control
R6869	T10636	T10646	causeOf	mTORC1,contribute
R6874	T10640	T10645	themeOf	upregulation,contribute
R6875	T10640	T10646	themeOf	upregulation,contribute
R6877	T10642	T10647	themeOf	knockdown,inhibition
R6878	T10642	T10649	themeOf	knockdown,siRNA
R6879	T10643	T10648	themeOf	knockdown,inhibition
R6880	T10643	T10650	themeOf	knockdown,siRNA
R6881	T10651	T10656	themeOf	RIP1,inhibitors
R6882	T10652	T10657	themeOf	Akt,inhibitors
R6883	T10653	T10658	themeOf	TNFα mRNA,effect
R6884	T10653	T10659	themeOf	TNFα mRNA,effect
R6885	T10655	T10660	themeOf	TNFα,synthesis
R6886	T10656	T10658	causeOf	inhibitors,effect
R6887	T10657	T10659	causeOf	inhibitors,effect
R6888	T10660	T10661	themeOf	synthesis,increase
R21200	T30581	T30584	themeOf	Akt,inhibitors
R21201	T30582	T30585	themeOf	Akt,inhibitors
R21202	T30583	T30586	themeOf	mTOR,inhibitors
R21203	T30587	T30589	themeOf	mTOR siRNA,knockdown
R21362	T30916	T30923	causeOf	Akt,control
R21363	T30916	T30924	causeOf	Akt,control
R21364	T30917	T30925	causeOf	mTORC1,control
R21365	T30917	T30926	causeOf	mTORC1,control
R21366	T30917	T30927	causeOf	mTORC1,control
R21367	T30918	T30920	themeOf	TNFα,synthesis
R21368	T30919	T30921	themeOf	JNK,activation
R21369	T30920	T30922	themeOf	synthesis,activation
R21370	T30920	T30925	themeOf	synthesis,control
R21371	T30921	T30923	themeOf	activation,control
R21372	T30921	T30926	themeOf	activation,control
R21373	T30922	T30924	themeOf	activation,control
R21374	T30922	T30927	themeOf	activation,control
R21375	T30938	T30941	themeOf	Akt,knockdown
R6816	T10532	T10533	themeOf	Akt kinase,increase
R6817	T10542	T10545	themeOf	FoxO1,increase
R6818	T10548	T10553	themeOf	Akt,phosphorylation
R6819	T10549	T10551	themeOf	Fig. 5B,phosphorylation
R6820	T10550	T10552	themeOf	S5A,phosphorylation
R6821	T10553	T10554	themeOf	phosphorylation,increase
R6822	T10555	T10560	themeOf	Akt,increases
R6823	T10556	T10561	causeOf	Nec-1,abrogated
R6824	T10556	T10562	causeOf	Nec-1,abrogated
R6825	T10557	T10561	themeOf	Fig. 5A,abrogated
R6826	T10560	T10562	themeOf	increases,abrogated
R6827	T10566	T10568	themeOf	mTORC1,inhibition
R6828	T10567	T10569	themeOf	mTOR,inhibitor
R6829	T10570	T10573	themeOf	mTOR kinase,inhibitor
R6830	T10571	T10574	themeOf	PI3K,inhibitor
R6831	T10572	T10575	themeOf	mTOR,inhibitor
R6832	T10576	T10580	themeOf	mTOR using siRNA,Knockdown
R6833	T10581	T10584	causeOf	mTORC1,regulates
R6834	T10582	T10583	themeOf	p70S6 kinase,activation
R6835	T10583	T10584	themeOf	activation,regulates
R6836	T10585	T10586	themeOf	S6,phosphorylation
R6837	T10586	T10587	themeOf	phosphorylation,block
R6838	T10588	T10591	themeOf	S6,knockdown
R6839	T10593	T10599	causeOf	RIP1 kinase,control
R6840	T10594	T10600	causeOf	Akt,control
R6841	T10595	T10601	causeOf	mTORC1,control
R6842	T10596	T10602	causeOf	JNK,control
R6843	T10597	T10598	themeOf	TNFα,upregulation
R6844	T10598	T10599	themeOf	upregulation,control
R6845	T10598	T10600	themeOf	upregulation,control
R6846	T10598	T10601	themeOf	upregulation,control
R6847	T10598	T10602	themeOf	upregulation,control
R6848	T10603	T10604	themeOf	TNFα,synthesis
R6849	T10605	T10606	themeOf	TNFα,synthesis
R6850	T10607	T10614	causeOf	RIP1,increase
R6851	T10607	T10615	causeOf	RIP1,increase
R6852	T10608	T10614	themeOf	TNFα protein,increase
R6853	T10610	T10615	themeOf	S6A,increase
R6854	T10611	T10616	themeOf	TNFα mRNA,increased
R6855	T10612	T10617	themeOf	RIP1,increased
R6856	T10613	T10616	causeOf	Fig,increased
R6857	T10613	T10617	causeOf	Fig,increased
R6858	T10619	T10624	causeOf	bFGF,triggered
R6859	T10620	T10623	themeOf	TNFα mRNA,induction
R6860	T10623	T10624	themeOf	induction,triggered
R6861	T10625	T10633	causeOf	PDGF,caused
R6862	T10626	T10630	themeOf	TNFα mRNA,upregulation
R6863	T10628	T10631	causeOf	Fig. 6A,increased
R6864	T10629	T10632	themeOf	autocrine TNFα,synthesis
R6865	T10630	T10631	themeOf	upregulation,increased
R6866	T10630	T10633	themeOf	upregulation,caused
R6867	T10632	T10634	themeOf	synthesis,increase
R6868	T10635	T10645	causeOf	Akt,contribute
R6870	T10637	T10640	themeOf	TNFα mRNA,upregulation
R6871	T10638	T10641	themeOf	Akt,siRNA
R6872	T10638	T10642	themeOf	Akt,knockdown
R6873	T10639	T10644	themeOf	mTOR reduced TNFα mRNA,levels
R6876	T10641	T10643	themeOf	siRNA,knockdown

test3

Id	Subject	Object	Predicate	Lexical cue
T30668	5184-5189	Protein	denotes	mTNFα
T30667	5137-5141	Protein	denotes	TNFα
T30666	5058-5067	Negative_regulation	denotes	knockdown
T30665	5012-5016	Protein	denotes	TNFα
T30664	4906-4910	Protein	denotes	TNFα
T30663	4854-4857	Protein	denotes	18S
T30662	4818-4823	Protein	denotes	mTNFα
T30661	4738-4742	Protein	denotes	bFGF
T30660	4628-4632	Protein	denotes	TNFα
T30659	5184-5189	Protein	denotes	mTNFα
T30658	5137-5141	Protein	denotes	TNFα
T30657	5012-5016	Protein	denotes	TNFα
T30656	4906-4910	Protein	denotes	TNFα
T30655	4854-4857	Protein	denotes	18S
T30654	4818-4823	Protein	denotes	mTNFα
T30653	4738-4742	Protein	denotes	bFGF
T30652	4628-4632	Protein	denotes	TNFα
T30232	1928-1932	Protein	denotes	TNFα
T30231	1752-1762	Negative_regulation	denotes	inhibitors
T30230	1715-1719	Protein	denotes	TNFα
T30229	1692-1699	Positive_regulation	denotes	induced
T30228	1562-1566	Protein	denotes	bFGF
T30227	1554-1558	Protein	denotes	bFGF
T30226	1454-1458	Protein	denotes	TNFα
T30225	1928-1932	Protein	denotes	TNFα
T30224	1715-1719	Protein	denotes	TNFα
T30223	1562-1566	Protein	denotes	bFGF
T30222	1554-1558	Protein	denotes	bFGF
T30221	1454-1458	Protein	denotes	TNFα
T9010	380-395	Protein	denotes	double minute 2
T9009	268-283	Phosphorylation	denotes	phosphorylation
T9008	252-260	Positive_regulation	denotes	increase
T9007	144-159	Phosphorylation	denotes	phosphorylation
T9006	125-133	Positive_regulation	denotes	increase
T9005	5746-5750	Protein	denotes	TNFα
T9004	5627-5631	Protein	denotes	bFGF
T9003	5568-5572	Protein	denotes	TNFα
T9002	5513-5517	Protein	denotes	RIP1
T9001	5451-5455	Protein	denotes	TNFα
T9000	5344-5348	Protein	denotes	TNFα
T8999	4535-4539	Protein	denotes	TNFα
T8998	4346-4350	Protein	denotes	TNFα
T8997	4177-4181	Protein	denotes	TNFα
T8996	4138-4142	Protein	denotes	bFGF
T8995	4093-4097	Protein	denotes	RIP1
T8994	4028-4032	Protein	denotes	TNFα
T8993	3986-3990	Protein	denotes	TNFα
T8992	3959-3963	Protein	denotes	RIP1
T8991	3925-3929	Protein	denotes	TNFα
T8990	3822-3826	Protein	denotes	TNFα
T8989	3647-3651	Protein	denotes	TNFα
T8988	3586-3590	Protein	denotes	RIP1
T8987	3338-3340	Protein	denotes	S6
T8986	3331-3337	Protein	denotes	p70S6K
T8985	3236-3238	Protein	denotes	S6
T8984	3175-3177	Protein	denotes	S6
T8983	3089-3095	Protein	denotes	p70S6K
T8982	2911-2913	Protein	denotes	S6
T8981	2861-2873	Protein	denotes	p70S6 kinase
T8980	2780-2784	Protein	denotes	TNFα
T8979	2405-2411	Protein	denotes	Raptor
T8978	1288-1292	Protein	denotes	RIP1
T8977	793-799	Protein	denotes	pFoxO1
T8976	621-623	Protein	denotes	S6
T8975	596-602	Protein	denotes	p70S6K
T8974	593-594	Protein	denotes	β
T8973	586-592	Protein	denotes	GSK-3α
T8972	578-584	Protein	denotes	FoxO3a
T8971	523-527	Protein	denotes	MDM2
T8970	516-521	Protein	denotes	FoxO4
T8969	509-514	Protein	denotes	FoxO1
T8968	479-481	Protein	denotes	S6
T8967	470-476	Protein	denotes	p70S6K
T8966	437-468	Protein	denotes	p70 ribosomal protein S6 Kinase
T8965	397-401	Protein	denotes	MDM2
T8964	380-395	Protein	denotes	double minute 2
T9083	5751-5760	Gene_expression	denotes	synthesis
T9082	5746-5750	Protein	denotes	TNFα
T9081	5734-5742	Positive_regulation	denotes	increase
T9080	5627-5631	Protein	denotes	bFGF
T9079	5568-5572	Protein	denotes	TNFα
T9078	5544-5550	Regulation	denotes	effect
T9077	5526-5536	Negative_regulation	denotes	inhibitors
T9076	5513-5517	Protein	denotes	RIP1
T9075	5451-5455	Protein	denotes	TNFα
T9074	5443-5450	Negative_regulation	denotes	reduced
T9073	5417-5426	Negative_regulation	denotes	knockdown
T9072	5344-5348	Protein	denotes	TNFα
T9071	5328-5340	Positive_regulation	denotes	upregulation
T9070	5310-5320	Positive_regulation	denotes	contribute
T9069	4540-4549	Gene_expression	denotes	synthesis
T9068	4535-4539	Protein	denotes	TNFα
T9067	4379-4388	Positive_regulation	denotes	increased
T9066	4346-4350	Protein	denotes	TNFα
T9065	4330-4342	Positive_regulation	denotes	upregulation
T9064	4314-4320	Positive_regulation	denotes	caused
T9063	4277-4285	Positive_regulation	denotes	increase
T9062	4177-4181	Protein	denotes	TNFα
T9061	4164-4173	Positive_regulation	denotes	induction
T9060	4149-4158	Positive_regulation	denotes	triggered
T9059	4138-4142	Protein	denotes	bFGF
T9058	4093-4097	Protein	denotes	RIP1
T9057	4028-4032	Protein	denotes	TNFα
T9056	3986-3990	Protein	denotes	TNFα
T9055	3974-3982	Positive_regulation	denotes	increase
T9054	3964-3973	Regulation	denotes	dependent
T9053	3959-3963	Protein	denotes	RIP1
T9052	3930-3939	Gene_expression	denotes	synthesis
T9051	3925-3929	Protein	denotes	TNFα
T9050	3911-3921	Positive_regulation	denotes	contribute
T9049	3822-3826	Protein	denotes	TNFα
T9048	3809-3818	Gene_expression	denotes	synthesis
T9047	3799-3808	Positive_regulation	denotes	increased
T9046	3647-3651	Protein	denotes	TNFα
T9045	3631-3643	Positive_regulation	denotes	upregulation
T9044	3586-3590	Protein	denotes	RIP1
T9043	3338-3340	Protein	denotes	S6
T9042	3331-3337	Protein	denotes	p70S6K
T9041	3236-3238	Protein	denotes	S6
T9040	3178-3193	Phosphorylation	denotes	phosphorylation
T9039	3175-3177	Protein	denotes	S6
T9038	3089-3095	Protein	denotes	p70S6K
T9037	2911-2913	Protein	denotes	S6
T9036	2861-2873	Protein	denotes	p70S6 kinase
T9035	2785-2792	Positive_regulation	denotes	induced
T9034	2780-2784	Protein	denotes	TNFα
T9033	2613-2622	Negative_regulation	denotes	Knockdown
T9032	2580-2589	Negative_regulation	denotes	inhibited
T9031	2541-2550	Negative_regulation	denotes	inhibitor
T9030	2496-2505	Negative_regulation	denotes	inhibitor
T9029	2405-2411	Protein	denotes	Raptor
T9028	2373-2382	Negative_regulation	denotes	inhibitor
T9027	1288-1292	Protein	denotes	RIP1
T9026	1093-1102	Negative_regulation	denotes	abrogated
T9025	793-799	Protein	denotes	pFoxO1
T9024	743-758	Phosphorylation	denotes	phosphorylation
T9023	727-735	Positive_regulation	denotes	increase
T9022	621-623	Protein	denotes	S6
T9021	596-602	Protein	denotes	p70S6K
T9020	593-594	Protein	denotes	β
T9019	586-592	Protein	denotes	GSK-3α
T9018	578-584	Protein	denotes	FoxO3a
T9017	523-527	Protein	denotes	MDM2
T9016	516-521	Protein	denotes	FoxO4
T9015	509-514	Protein	denotes	FoxO1
T9014	479-481	Protein	denotes	S6
T9013	470-476	Protein	denotes	p70S6K
T9012	437-468	Protein	denotes	p70 ribosomal protein S6 Kinase
T9011	397-401	Protein	denotes	MDM2
R5825	T9007	T9006	themeOf	phosphorylation,increase
R5826	T9009	T9008	themeOf	phosphorylation,increase
R5827	T9010	T9009	themeOf	double minute 2,phosphorylation
R5828	T9011	T9010	equivalentTo	MDM2,double minute 2
R5829	T9012	T9010	equivalentTo	p70 ribosomal protein S6 Kinase,double minute 2
R5830	T9013	T9010	equivalentTo	p70S6K,double minute 2
R5831	T9013	T9012	equivalentTo	p70S6K,p70 ribosomal protein S6 Kinase
R5832	T9014	T9009	themeOf	S6,phosphorylation
R5833	T9024	T9023	themeOf	phosphorylation,increase
R5834	T9029	T9028	themeOf	Raptor,inhibitor
R5835	T9039	T9040	themeOf	S6,phosphorylation
R5836	T9046	T9045	themeOf	TNFα,upregulation
R5837	T9048	T9047	themeOf	synthesis,increased
R5838	T9049	T9048	themeOf	TNFα,synthesis
R5839	T9051	T9052	themeOf	TNFα,synthesis
R5840	T9052	T9050	themeOf	synthesis,contribute
R5841	T9053	T9055	causeOf	RIP1,increase
R5842	T9053	T9054	causeOf	RIP1,dependent
R5843	T9055	T9054	themeOf	increase,dependent
R5844	T9056	T9055	themeOf	TNFα,increase
R5845	T9059	T9060	causeOf	bFGF,triggered
R5846	T9061	T9063	themeOf	induction,increase
R5847	T9061	T9060	themeOf	induction,triggered
R5848	T9062	T9061	themeOf	TNFα,induction
R5849	T9065	T9064	themeOf	upregulation,caused
R5850	T9065	T9067	themeOf	upregulation,increased
R5851	T9066	T9065	themeOf	TNFα,upregulation
R5852	T9068	T9069	themeOf	TNFα,synthesis
R5853	T9071	T9070	themeOf	upregulation,contribute
R5854	T9072	T9071	themeOf	TNFα,upregulation
R5855	T9073	T9074	causeOf	knockdown,reduced
R5856	T9076	T9077	themeOf	RIP1,inhibitors
R5857	T9077	T9078	causeOf	inhibitors,effect
R5858	T9080	T9078	causeOf	bFGF,effect
R5859	T9082	T9083	themeOf	TNFα,synthesis
R5860	T9083	T9081	themeOf	synthesis,increase
R20933	T30231	T30229	causeOf	inhibitors,induced
R21208	T30667	T30666	themeOf	TNFα,knockdown

PMC:3585731 / 19836-25597 JSONTXT

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PMC:3585731 / 19836-25597 JSON TXT