PMC:3585731 / 1366-2078 JSONTXT

{"project":"2_test","denotations":[{"id":"23469174-20010783-90505392","span":{"begin":97,"end":98},"obj":"20010783"},{"id":"23469174-21773880-90505393","span":{"begin":352,"end":353},"obj":"21773880"},{"id":"23469174-21749897-90505394","span":{"begin":357,"end":358},"obj":"21749897"},{"id":"23469174-21804564-90505395","span":{"begin":533,"end":534},"obj":"21804564"},{"id":"23469174-21921917-90505396","span":{"begin":538,"end":539},"obj":"21921917"},{"id":"23469174-22195746-90505397","span":{"begin":543,"end":544},"obj":"22195746"}],"text":"Necroptosis is a form of regulated cell death that displays all the major hallmarks of necrosis [1]. A growing number of studies have implicated necroptosis in a wide range of animal models of human disease, including brain, heart and retinal ischemia-reperfusion injury, acute pancreatitis, brain trauma, retinal detachment, and Huntington’s disease [2], [3]. Importantly, several recent studies have linked necroptosis to models of inflammation including intestinal inflammation and systemic inflammatory response syndrome (SIRS) [4], [5], [6]. The discovery of a regulated form of necrotic death could uncover molecular targets amenable to pharmacological intervention for the treatment of various conditions."}

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is a form of regulated cell death that displays all the major hallmarks of necrosis [1]. A growing number of studies have implicated necroptosis in a wide range of animal models of human disease, including brain, heart and retinal ischemia-reperfusion injury, acute pancreatitis, brain trauma, retinal detachment, and Huntington’s disease [2], [3]. Importantly, several recent studies have linked necroptosis to models of inflammation including intestinal inflammation and systemic inflammatory response syndrome (SIRS) [4], [5], [6]. The discovery of a regulated form of necrotic death could uncover molecular targets amenable to pharmacological intervention for the treatment of various conditions."}

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