PMC:3585731 / 12012-12165 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T5103	109-116	Positive_regulation	denotes	induced
T5102	23-32	Negative_regulation	denotes	knockdown
T5064	138-142	Protein	denotes	TNFα
T5063	58-62	Protein	denotes	Akt2
T5062	49-53	Protein	denotes	Akt1
R3496	T5062	T5102	themeOf	Akt1,knockdown
R3497	T5063	T5102	themeOf	Akt2,knockdown
R3498	T5064	T5103	causeOf	TNFα,induced
R3518	T5102	T5103	themeOf	knockdown,induced

Id	Subject	Object	Predicate	Lexical cue
T5821	151-152	-RRB-	denotes	)
T5820	149-151	NN	denotes	2C
T5819	144-148	NN	denotes	Fig.
T5818	143-144	-LRB-	denotes	(
T5817	138-142	NN	denotes	TNFα
T5816	134-137	CC	denotes	and
T5815	125-133	NN	denotes	zVAD.fmk
T5814	120-124	CC	denotes	both
T5813	117-119	IN	denotes	by
T5812	109-116	VB	denotes	induced
T5811	97-108	NN	denotes	necroptosis
T5810	92-96	IN	denotes	from
T5809	86-91	NN	denotes	cells
T5808	76-85	VB	denotes	protected
T5807	69-75	NN	denotes	siRNAs
T5806	63-68	VB	denotes	using
T5805	58-62	NN	denotes	Akt2
T5804	54-57	CC	denotes	and
T5803	49-53	NN	denotes	Akt1
T5802	40-48	NN	denotes	isoforms
T5801	36-39	NN	denotes	Akt
T5800	33-35	IN	denotes	of
T5799	23-32	NN	denotes	knockdown
T5798	10-22	JJ	denotes	simultaneous
T5797	8-9	-COMMA-	denotes	,
T5796	0-8	RB	denotes	Secondly
R3849	T5799	T5798	arg1Of	knockdown,simultaneous
R3850	T5799	T5800	arg1Of	knockdown,of
R3851	T5799	T5808	arg1Of	knockdown,protected
R3852	T5802	T5801	arg1Of	isoforms,Akt
R3853	T5803	T5804	arg1Of	Akt1,and
R3854	T5804	T5800	arg2Of	and,of
R3855	T5804	T5802	arg1Of	and,isoforms
R3856	T5804	T5806	arg1Of	and,using
R3857	T5805	T5804	arg2Of	Akt2,and
R3858	T5807	T5806	arg2Of	siRNAs,using
R3859	T5808	T5796	arg1Of	protected,Secondly
R3860	T5808	T5797	arg1Of	protected,","
R3861	T5809	T5808	arg2Of	cells,protected
R3862	T5809	T5810	arg1Of	cells,from
R3863	T5811	T5810	arg2Of	necroptosis,from
R3864	T5811	T5812	arg2Of	necroptosis,induced
R3865	T5815	T5816	arg1Of	zVAD.fmk,and
R3866	T5816	T5812	arg1Of	and,induced
R3867	T5816	T5813	arg2Of	and,by
R3868	T5816	T5814	arg1Of	and,both
R3869	T5816	T5818	arg1Of	and,(
R3870	T5817	T5816	arg2Of	TNFα,and
R3871	T5820	T5818	arg2Of	2C,(
R3872	T5820	T5819	arg1Of	2C,Fig.
R3873	T5821	T5818	arg3Of	),(

Id	Subject	Object	Predicate	Lexical cue
T5375	138-142	Protein	denotes	TNFα
T5374	58-62	Protein	denotes	Akt2
T5373	49-53	Protein	denotes	Akt1

Id	Subject	Object	Predicate	Lexical cue
T6500	36-39	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6472	36-39	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6444	36-39	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6530	138-142	http://www.uniprot.org/uniprot/P01375	denotes	TNFα

Id	Subject	Object	Predicate	Lexical cue
T5414	97-108	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T5404	97-108	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis

Id	Subject	Object	Predicate	Lexical cue
T5513	86-91	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

Id	Subject	Object	Predicate	Lexical cue
T5288	0-153	Sentence	denotes	Secondly, simultaneous knockdown of Akt isoforms Akt1 and Akt2 using siRNAs protected cells from necroptosis induced by both zVAD.fmk and TNFα (Fig. 2C).
T77	0-153	Sentence	denotes	Secondly, simultaneous knockdown of Akt isoforms Akt1 and Akt2 using siRNAs protected cells from necroptosis induced by both zVAD.fmk and TNFα (Fig. 2C).

Id	Subject	Object	Predicate	Lexical cue
T5528	138-142	Protein	denotes	TNFα
T5527	58-62	Protein	denotes	Akt2
T5526	49-53	Protein	denotes	Akt1

Id	Subject	Object	Predicate	Lexical cue
T6413	23-32	Negative_regulation	denotes	knockdown
T6387	138-142	Protein	denotes	TNFα
T6386	58-62	Protein	denotes	Akt2
T6385	49-53	Protein	denotes	Akt1
R4400	T6385	T6413	themeOf	Akt1,knockdown
R4401	T6386	T6413	themeOf	Akt2,knockdown

Id	Subject	Object	Predicate	Lexical cue
T6697	23-32	Negative_regulation	denotes	knockdown
T6696	109-116	Positive_regulation	denotes	induced
T6668	138-142	Protein	denotes	TNFα
T6667	58-62	Protein	denotes	Akt2
T6666	49-53	Protein	denotes	Akt1
R4480	T6666	T6697	themeOf	Akt1,knockdown
R4481	T6667	T6697	themeOf	Akt2,knockdown
R4482	T6668	T6696	themeOf	TNFα,induced

Id	Subject	Object	Predicate	Lexical cue
T6576	69-75	Negative_regulation	denotes	siRNAs
T6575	23-32	Negative_regulation	denotes	knockdown
T6548	138-142	Protein	denotes	TNFα
T6547	58-62	Protein	denotes	Akt2
T6546	49-53	Protein	denotes	Akt1
R4423	T6546	T6575	themeOf	Akt1,knockdown
R4424	T6546	T6576	themeOf	Akt1,siRNAs
R4425	T6547	T6575	themeOf	Akt2,knockdown
R4426	T6547	T6576	themeOf	Akt2,siRNAs
R4442	T6576	T6575	themeOf	siRNAs,knockdown
R4443	T6576	T6575	themeOf	siRNAs,knockdown

Id	Subject	Object	Predicate	Lexical cue
T7256	58-75	Protein	denotes	Akt2 using siRNAs
T7249	138-142	Protein	denotes	TNFα
T7233	36-53	Protein	denotes	Akt isoforms Akt1
T7217	86-91	Entity	denotes	cells
T7215	144-147	Protein	denotes	Fig
T7158	125-133	Entity	denotes	zVAD.fmk
T7150	36-39	Protein	denotes	Akt

Id	Subject	Object	Predicate	Lexical cue
T6756	76-85	Gene_expression	denotes	protected
T6755	23-32	Negative_regulation	denotes	knockdown
T6754	23-32	Negative_regulation	denotes	knockdown
T6753	23-32	Negative_regulation	denotes	knockdown
T6752	144-151	Protein	denotes	Fig. 2C
T6751	138-142	Protein	denotes	TNFα
T6750	125-133	Protein	denotes	zVAD.fmk
T6749	58-62	Protein	denotes	Akt2
T6748	49-53	Protein	denotes	Akt1
T6747	36-39	Protein	denotes	Akt
R4526	T6747	T6753	themeOf	Akt,knockdown
R4527	T6748	T6754	themeOf	Akt1,knockdown
R4528	T6749	T6755	themeOf	Akt2,knockdown
R4530	T6752	T6756	themeOf	Fig. 2C,protected

Id	Subject	Object	Predicate	Lexical cue
T5206	138-142	Protein	denotes	TNFα
T5205	109-116	Positive_regulation	denotes	induced
T5204	58-62	Protein	denotes	Akt2
T5203	49-53	Protein	denotes	Akt1
T5202	23-32	Negative_regulation	denotes	knockdown
T5160	138-142	Protein	denotes	TNFα
T5159	58-62	Protein	denotes	Akt2
T5158	49-53	Protein	denotes	Akt1
R3541	T5202	T5205	themeOf	knockdown,induced
R3542	T5203	T5202	themeOf	Akt1,knockdown
R3543	T5204	T5202	themeOf	Akt2,knockdown
R3544	T5206	T5205	causeOf	TNFα,induced