PMC:3585731 / 10105-16461 JSON TXT

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testone

Id	Subject	Object	Predicate	Lexical cue
T29388	3137-3152	Phosphorylation	denotes	phosphorylation
T29387	3127-3136	Regulation	denotes	dependent
T29386	3527-3531	Protein	denotes	bFGF
T29385	3519-3523	Protein	denotes	bFGF
T29384	3355-3359	Protein	denotes	bFGF
T29383	3233-3237	Protein	denotes	TNFα
T29382	3115-3119	Protein	denotes	RIP1
T28927	1519-1529	Gene_expression	denotes	expression
T28926	1269-1278	Negative_regulation	denotes	inhibitor
T28925	1246-1256	Negative_regulation	denotes	inhibitors
T28924	1140-1147	Positive_regulation	denotes	induced
T28923	1088-1095	Positive_regulation	denotes	induced
T28922	1480-1484	Protein	denotes	TNFα
T28921	1427-1438	Protein	denotes	Akt3 siRNAs
T28920	1417-1421	Protein	denotes	Akt2
T28919	1411-1415	Protein	denotes	Akt1
T28918	1163-1167	Protein	denotes	TNFα
T28917	1112-1116	Protein	denotes	TNFα
T5151	6219-6234	Phosphorylation	denotes	phosphorylation
T5150	6194-6203	Positive_regulation	denotes	increases
T5149	6098-6113	Phosphorylation	denotes	phosphorylation
T5148	6075-6083	Positive_regulation	denotes	increase
T5147	5946-5961	Phosphorylation	denotes	phosphorylation
T5146	5863-5878	Phosphorylation	denotes	phosphorylation
T5145	5851-5859	Positive_regulation	denotes	increase
T5144	5777-5792	Phosphorylation	denotes	phosphorylation
T5143	5758-5766	Positive_regulation	denotes	increase
T5142	5565-5575	Positive_regulation	denotes	activation
T5141	5502-5510	Positive_regulation	denotes	increase
T5140	5480-5487	Negative_regulation	denotes	blocked
T5139	5370-5379	Positive_regulation	denotes	triggered
T5138	5354-5369	Phosphorylation	denotes	phosphorylation
T5137	5319-5327	Positive_regulation	denotes	increase
T5136	5299-5305	Regulation	denotes	effect
T5135	5213-5221	Positive_regulation	denotes	increase
T5134	5142-5157	Phosphorylation	denotes	phosphorylation
T5133	5126-5134	Positive_regulation	denotes	increase
T5132	5093-5099	Positive_regulation	denotes	caused
T5131	4883-4898	Phosphorylation	denotes	phosphorylation
T5130	4848-4856	Positive_regulation	denotes	increase
T5129	4620-4630	Regulation	denotes	regulation
T5128	4410-4419	Positive_regulation	denotes	following
T5127	4351-4366	Phosphorylation	denotes	phosphorylation
T5126	4302-4311	Regulation	denotes	dependent
T5125	4259-4274	Phosphorylation	denotes	phosphorylation
T5124	4163-4178	Phosphorylation	denotes	phosphorylation
T5123	4147-4152	Regulation	denotes	alter
T5122	4099-4109	Negative_regulation	denotes	attenuated
T5121	4070-4078	Positive_regulation	denotes	increase
T5120	3990-3999	Positive_regulation	denotes	following
T5119	3883-3890	Negative_regulation	denotes	reduced
T5118	3718-3733	Phosphorylation	denotes	phosphorylation
T5117	3695-3703	Positive_regulation	denotes	increase
T5116	3681-3690	Negative_regulation	denotes	prevented
T5115	3652-3661	Negative_regulation	denotes	inhibitor
T5114	2888-2903	Phosphorylation	denotes	phosphorylation
T5113	2872-2880	Positive_regulation	denotes	increase
T5112	2792-2799	Regulation	denotes	changes
T5111	2776-2791	Phosphorylation	denotes	phosphorylation
T5110	2662-2677	Phosphorylation	denotes	phosphorylation
T5109	2646-2654	Positive_regulation	denotes	increase
T5108	2407-2422	Phosphorylation	denotes	phosphorylation
T5107	2384-2391	Regulation	denotes	changes
T5106	2312-2322	Positive_regulation	denotes	activation
T5105	2251-2258	Positive_regulation	denotes	induced
T5104	2064-2074	Gene_expression	denotes	expression
T5103	2016-2023	Positive_regulation	denotes	induced
T5102	1930-1939	Negative_regulation	denotes	knockdown
T5101	1846-1859	Localization	denotes	translocation
T5100	1830-1836	Negative_regulation	denotes	blocks
T5099	1724-1734	Negative_regulation	denotes	inhibitors
T5098	988-995	Positive_regulation	denotes	induced
T5097	834-844	Negative_regulation	denotes	inhibition
T5096	552-562	Negative_regulation	denotes	Inhibition
T5095	344-353	Negative_regulation	denotes	inhibitor
T5094	321-331	Negative_regulation	denotes	Inhibition
T5093	266-275	Positive_regulation	denotes	following
T5092	256-265	Positive_regulation	denotes	activated
T5091	22-32	Positive_regulation	denotes	Activation
T5090	12-21	Regulation	denotes	dependent
T5089	6344-6348	Protein	denotes	RIP1
T5088	6060-6064	Protein	denotes	RIP1
T5087	5636-5640	Protein	denotes	RIP1
T5086	5492-5496	Protein	denotes	bFGF
T5085	5397-5401	Protein	denotes	bFGF
T5084	5388-5392	Protein	denotes	bFGF
T5083	5348-5353	Protein	denotes	c-Jun
T5082	5076-5080	Protein	denotes	bFGF
T5081	5053-5057	Protein	denotes	bFGF
T5080	4925-4930	Protein	denotes	c-Jun
T5079	4764-4768	Protein	denotes	bFGF
T5078	4593-4597	Protein	denotes	RIP1
T5077	4297-4301	Protein	denotes	RIP1
T5076	4082-4087	Protein	denotes	c-Jun
T5075	3984-3989	Protein	denotes	c-Jun
T5074	3909-3913	Protein	denotes	TNFα
T5073	3714-3717	Protein	denotes	Akt
T5072	3640-3644	Protein	denotes	RIP1
T5071	2968-2973	Protein	denotes	c-Jun
T5070	2924-2927	Protein	denotes	p54
T5069	2916-2919	Protein	denotes	p46
T5068	2620-2624	Protein	denotes	TNFα
T5067	2450-2454	Protein	denotes	TNFα
T5066	2136-2146	Protein	denotes	Akt3 siRNA
T5065	2078-2082	Protein	denotes	Akt3
T5064	2045-2049	Protein	denotes	TNFα
T5063	1965-1969	Protein	denotes	Akt2
T5062	1956-1960	Protein	denotes	Akt1
T5061	983-987	Protein	denotes	TNFα
T5060	765-769	Protein	denotes	TNFα
T5059	645-649	Protein	denotes	TNFα
T5058	498-503	Protein	denotes	IGF-1
T5057	490-494	Protein	denotes	bFGF
R3496	T5062	T5102	themeOf	Akt1,knockdown
R3497	T5063	T5102	themeOf	Akt2,knockdown
R3498	T5064	T5103	causeOf	TNFα,induced
R3499	T5065	T5104	themeOf	Akt3,expression
R3500	T5067	T5108	themeOf	TNFα,phosphorylation
R3501	T5068	T5109	causeOf	TNFα,increase
R3502	T5069	T5114	themeOf	p46,phosphorylation
R3503	T5070	T5114	themeOf	p54,phosphorylation
R3504	T5071	T5114	themeOf	c-Jun,phosphorylation
R3505	T5072	T5115	themeOf	RIP1,inhibitor
R3506	T5073	T5118	themeOf	Akt,phosphorylation
R3507	T5074	T5119	causeOf	TNFα,reduced
R3508	T5076	T5121	themeOf	c-Jun,increase
R3509	T5077	T5125	themeOf	RIP1,phosphorylation
R3510	T5080	T5131	themeOf	c-Jun,phosphorylation
R3511	T5083	T5138	themeOf	c-Jun,phosphorylation
R3512	T5084	T5139	causeOf	bFGF,triggered
R3513	T5085	T5139	causeOf	bFGF,triggered
R3514	T5086	T5141	themeOf	bFGF,increase
R3515	T5088	T5148	causeOf	RIP1,increase
R3516	T5092	T5093	themeOf	activated,following
R3517	T5101	T5100	themeOf	translocation,blocks
R3518	T5102	T5103	themeOf	knockdown,induced
R3519	T5110	T5109	themeOf	phosphorylation,increase
R3520	T5114	T5113	themeOf	phosphorylation,increase
R3521	T5115	T5116	causeOf	inhibitor,prevented
R3522	T5117	T5116	themeOf	increase,prevented
R3523	T5118	T5117	themeOf	phosphorylation,increase
R3524	T5121	T5122	themeOf	increase,attenuated
R3525	T5124	T5123	themeOf	phosphorylation,alter
R3526	T5125	T5126	themeOf	phosphorylation,dependent
R3527	T5127	T5128	themeOf	phosphorylation,following
R3528	T5131	T5130	themeOf	phosphorylation,increase
R3529	T5134	T5133	themeOf	phosphorylation,increase
R3530	T5137	T5136	themeOf	increase,effect
R3531	T5138	T5139	themeOf	phosphorylation,triggered
R3532	T5138	T5137	themeOf	phosphorylation,increase
R3533	T5141	T5140	themeOf	increase,blocked
R3534	T5144	T5143	themeOf	phosphorylation,increase
R3535	T5146	T5145	themeOf	phosphorylation,increase
R3536	T5149	T5148	themeOf	phosphorylation,increase
R3537	T5151	T5150	themeOf	phosphorylation,increases
R20065	T28917	T28923	causeOf	TNFα,induced
R20066	T28918	T28924	causeOf	TNFα,induced
R20360	T29388	T29387	themeOf	phosphorylation,dependent

2_test

Id	Subject	Object	Predicate	Lexical cue
23469174-19556857-90505428	451-453	19556857	denotes	16
23469174-17560373-90505429	810-812	17560373	denotes	12
23469174-15131264-90505430	816-818	15131264	denotes	14
23469174-15131264-90505431	938-940	15131264	denotes	14
23469174-20571069-90505432	1792-1794	20571069	denotes	25
23469174-20489726-90505433	1819-1821	20489726	denotes	26

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T29552	3238-3241	IN	denotes	for
T29630	3624-3634	NN	denotes	antibodies
T29629	3614-3623	JJ	denotes	indicated
T29628	3610-3613	DT	denotes	the
T29627	3605-3609	IN	denotes	with
T29626	3600-3604	NN	denotes	blot
T29625	3592-3599	JJ	denotes	western
T29624	3589-3591	IN	denotes	by
T29623	3580-3588	VB	denotes	followed
T29622	3577-3579	NN	denotes	hr
T29621	3575-3576	CD	denotes	9
T29620	3572-3574	CC	denotes	or
T29619	3568-3571	NN	denotes	min
T29618	3565-3567	CD	denotes	15
T29617	3561-3564	IN	denotes	for
T29616	3559-3560	-RRB-	denotes	)
T29615	3549-3559	NN	denotes	conditions
T29614	3544-3548	JJ	denotes	free
T29613	3538-3543	NN	denotes	serum
T29612	3537-3538	-LRB-	denotes	(
T29611	3527-3536	NN	denotes	bFGF/zVAD
T29610	3524-3526	CC	denotes	or
T29609	3519-3523	NN	denotes	bFGF
T29608	3514-3518	IN	denotes	with
T29607	3503-3513	VB	denotes	stimulated
T29606	3497-3502	NN	denotes	cells
T29605	3493-3496	DT	denotes	the
T29604	3490-3492	TO	denotes	to
T29603	3484-3489	VB	denotes	added
T29602	3480-3483	VB	denotes	was
T29601	3474-3479	NN	denotes	Nec-1
T29600	3472-3473	-RRB-	denotes	)
T29599	3471-3472	NN	denotes	D
T29598	3470-3471	-LRB-	denotes	(
T29597	3464-3469	NN	denotes	blot.
T29596	3456-3463	JJ	denotes	western
T29595	3452-3455	IN	denotes	for
T29594	3445-3451	NN	denotes	points
T29593	3440-3444	NN	denotes	time
T29592	3430-3439	VB	denotes	indicated
T29591	3426-3429	DT	denotes	the
T29590	3423-3425	IN	denotes	at
T29589	3413-3422	VB	denotes	collected
T29588	3408-3412	VB	denotes	were
T29587	3400-3407	NN	denotes	samples
T29586	3396-3399	CC	denotes	and
T29585	3394-3395	-RRB-	denotes	)
T29584	3393-3394	NN	denotes	C
T29583	3391-3392	-COMMA-	denotes	,
T29582	3381-3391	NN	denotes	conditions
T29581	3376-3380	JJ	denotes	free
T29580	3370-3375	NN	denotes	serum
T29579	3369-3370	-LRB-	denotes	(
T29578	3355-3368	NN	denotes	bFGF/zVAD.fmk
T29577	3352-3354	CC	denotes	or
T29576	3350-3351	-RRB-	denotes	)
T29575	3349-3350	NN	denotes	B
T29574	3348-3349	-LRB-	denotes	(
T29573	3339-3347	NN	denotes	zVAD.fmk
T29572	3334-3338	IN	denotes	with
T29571	3326-3333	VB	denotes	treated
T29570	3321-3325	VB	denotes	were
T29569	3315-3320	NN	denotes	cells
T29568	3310-3314	NN	denotes	L929
T29567	3308-3309	-RRB-	denotes	)
T29566	3307-3308	NN	denotes	C
T29565	3306-3307	-COMMA-	denotes	,
T29564	3305-3306	NN	denotes	B
T29563	3304-3305	-LRB-	denotes	(
T29562	3292-3303	NN	denotes	antibodies.
T29561	3282-3291	VB	denotes	indicated
T29560	3277-3281	IN	denotes	with
T29559	3268-3276	NN	denotes	blotting
T29558	3260-3267	JJ	denotes	western
T29557	3257-3259	IN	denotes	by
T29556	3248-3256	VB	denotes	followed
T29555	3246-3247	-COMMA-	denotes	,
T29554	3244-3246	NN	denotes	hr
T29553	3242-3243	CD	denotes	9
T29551	3233-3237	NN	denotes	TNFα
T29550	3230-3232	CC	denotes	or
T29549	3221-3229	NN	denotes	zVAD.fmk
T29548	3216-3220	IN	denotes	with
T29547	3208-3215	VB	denotes	treated
T29546	3203-3207	VB	denotes	were
T29545	3197-3202	NN	denotes	cells
T29544	3192-3196	NN	denotes	L929
T29543	3190-3191	-RRB-	denotes	)
T29542	3189-3190	NN	denotes	A
T29541	3188-3189	-LRB-	denotes	(
T29540	3175-3186	NN	denotes	necroptosis
T29539	3168-3174	IN	denotes	during
T29538	3164-3167	NN	denotes	JNK
T29537	3160-3163	CC	denotes	and
T29536	3156-3159	NN	denotes	Akt
T29535	3153-3155	IN	denotes	of
T29534	3137-3152	NN	denotes	phosphorylation
T29533	3120-3136	JJ	denotes	kinase-dependent
T29532	3115-3119	NN	denotes	RIP1
T29029	1265-1268	NN	denotes	Akt
T29028	1264-1265	-LRB-	denotes	(
T29027	1260-1263	NN	denotes	Akt
T29026	1257-1259	IN	denotes	of
T29025	1246-1256	NN	denotes	inhibitors
T29024	1243-1245	IN	denotes	of
T29023	1234-1242	NN	denotes	presence
T29022	1230-1233	DT	denotes	the
T29021	1227-1229	IN	denotes	in
T29020	1225-1226	-RRB-	denotes	)
T29019	1224-1225	NN	denotes	B
T29018	1222-1223	-COMMA-	denotes	,
T29017	1218-1222	JJ	denotes	free
T29016	1212-1217	NN	denotes	serum
T29015	1211-1212	-LRB-	denotes	(
T29014	1194-1210	NN	denotes	factors/zVAD.fmk
T29013	1187-1193	NN	denotes	growth
T29012	1184-1186	CC	denotes	or
T29011	1182-1183	-RRB-	denotes	)
T29010	1181-1182	NN	denotes	A
T29009	1179-1180	-COMMA-	denotes	,
T29008	1174-1179	NN	denotes	serum
T29007	1169-1173	JJ	denotes	full
T29006	1168-1169	-LRB-	denotes	(
T29005	1163-1167	NN	denotes	TNFα
T29004	1160-1162	CC	denotes	or
T29003	1151-1159	NN	denotes	zVAD.fmk
T29002	1148-1150	IN	denotes	by
T29001	1140-1147	VB	denotes	induced
T29000	1136-1139	VB	denotes	was
T28999	1124-1135	NN	denotes	Necroptosis
T28998	1122-1123	-RRB-	denotes	)
T28997	1121-1122	NN	denotes	B
T28996	1120-1121	-COMMA-	denotes	,
T28995	1119-1120	NN	denotes	A
T28994	1118-1119	-LRB-	denotes	(
T28993	1112-1116	NN	denotes	TNFα
T28992	1108-1111	CC	denotes	and
T28991	1099-1107	NN	denotes	zVAD.fmk
T28990	1096-1098	IN	denotes	by
T28989	1088-1095	VB	denotes	induced
T28988	1076-1087	NN	denotes	necroptosis
T28987	1073-1075	TO	denotes	to
T28986	1061-1072	VB	denotes	contributes
T28985	1057-1060	NN	denotes	Akt
T29099	1597-1604	VB	denotes	plotted
T29098	1593-1596	VB	denotes	was
T29097	1582-1592	NN	denotes	average±SD
T29096	1580-1581	-COMMA-	denotes	,
T29095	1574-1580	NN	denotes	graphs
T29094	1570-1573	DT	denotes	all
T29093	1567-1569	IN	denotes	In
T29092	1562-1565	NN	denotes	hrs
T29091	1559-1561	CD	denotes	24
T29090	1553-1558	IN	denotes	after
T29089	1542-1552	VB	denotes	determined
T29088	1537-1541	VB	denotes	were
T29087	1530-1536	NN	denotes	levels
T29086	1519-1529	NN	denotes	expression
T29085	1515-1518	NN	denotes	Akt
T29084	1511-1514	CC	denotes	and
T29083	1501-1510	NN	denotes	viability
T29082	1496-1500	NN	denotes	Cell
T29081	1491-1494	NN	denotes	hrs
T29080	1489-1490	CD	denotes	9
T29079	1485-1488	IN	denotes	for
T29078	1480-1484	NN	denotes	TNFα
T29077	1477-1479	CC	denotes	or
T29076	1468-1476	NN	denotes	zVAD.fmk
T29075	1463-1467	IN	denotes	with
T29074	1455-1462	VB	denotes	treated
T29073	1450-1454	VB	denotes	were
T29072	1446-1449	NN	denotes	hrs
T29071	1443-1445	CD	denotes	72
T29070	1439-1442	IN	denotes	for
T29069	1432-1438	NN	denotes	siRNAs
T29068	1427-1431	NN	denotes	Akt3
T29067	1423-1426	CC	denotes	and
T29066	1421-1422	-COMMA-	denotes	,
T29065	1417-1421	NN	denotes	Akt2
T29064	1415-1416	-COMMA-	denotes	,
T29063	1411-1415	NN	denotes	Akt1
T29062	1406-1410	IN	denotes	with
T29061	1394-1405	VB	denotes	transfected
T29060	1388-1393	NN	denotes	cells
T29059	1383-1387	NN	denotes	L929
T29058	1381-1382	-RRB-	denotes	)
T29057	1380-1381	NN	denotes	C
T29056	1379-1380	-LRB-	denotes	(
T29055	1374-1378	NN	denotes	hrs.
T29054	1371-1373	CD	denotes	24
T29053	1365-1370	IN	denotes	after
T29052	1354-1364	VB	denotes	determined
T29051	1350-1353	VB	denotes	was
T29050	1340-1349	NN	denotes	viability
T29049	1335-1339	NN	denotes	Cell
T29048	1332-1333	-RRB-	denotes	)
T29047	1327-1332	NN	denotes	UO126
T29046	1326-1327	-LRB-	denotes	(
T29045	1322-1325	NN	denotes	Erk
T29044	1318-1321	CC	denotes	and
T29043	1316-1317	-COMMA-	denotes	,
T29042	1315-1316	-RRB-	denotes	)
T29041	1307-1315	NN	denotes	PD169316
T29040	1306-1307	-LRB-	denotes	(
T29039	1302-1305	NN	denotes	p38
T29038	1300-1301	-COMMA-	denotes	,
T29037	1299-1300	-RRB-	denotes	)
T29036	1291-1299	NN	denotes	SP600125
T29035	1290-1291	-LRB-	denotes	(
T29034	1286-1289	NN	denotes	JNK
T29033	1284-1285	-COMMA-	denotes	,
T29032	1283-1284	-RRB-	denotes	)
T29031	1279-1283	CD	denotes	VIII
T29030	1269-1278	NN	denotes	inhibitor
T6320	6186-6193	VB	denotes	delayed
T6319	6177-6185	VB	denotes	observed
T6318	6173-6176	DT	denotes	the
T6317	6168-6172	IN	denotes	that
T6316	6159-6167	VB	denotes	indicate
T6315	6151-6158	NN	denotes	results
T6314	6145-6150	DT	denotes	these
T6313	6143-6144	-COMMA-	denotes	,
T6312	6135-6143	RB	denotes	together
T6311	6129-6134	VB	denotes	Taken
T6310	6126-6127	-RRB-	denotes	)
T6309	6125-6126	NN	denotes	E
T6308	6123-6124	-COMMA-	denotes	,
T6307	6120-6123	NN	denotes	S3D
T6306	6115-6119	NNP	denotes	Fig.
T6305	6114-6115	-LRB-	denotes	(
T6304	6098-6113	NN	denotes	phosphorylation
T6303	6091-6097	NN	denotes	Thr308
T6302	6087-6090	NN	denotes	Akt
T6301	6084-6086	IN	denotes	in
T6300	6075-6083	NN	denotes	increase
T6299	6060-6074	JJ	denotes	RIP1-dependent
T6298	6039-6059	JJ	denotes	necroptosis-specific
T6297	6031-6038	VB	denotes	delayed
T6296	6024-6030	JJ	denotes	robust
T6295	6022-6023	DT	denotes	a
T6294	6015-6021	VB	denotes	showed
T6293	6010-6014	RB	denotes	also
T6292	6004-6009	WDT	denotes	which
T6291	6002-6003	-COMMA-	denotes	,
T6290	5997-6002	NN	denotes	assay
T6289	5991-5996	NN	denotes	ELISA
T6288	5978-5990	JJ	denotes	quantitative
T6287	5976-5977	DT	denotes	a
T6286	5970-5975	VB	denotes	using
T6285	5962-5969	NN	denotes	changes
T6284	5946-5961	NN	denotes	phosphorylation
T6283	5939-5945	NN	denotes	Ser473
T6282	5935-5938	CC	denotes	and
T6281	5928-5934	NN	denotes	Thr308
T6280	5924-5927	NN	denotes	Akt
T6279	5920-5923	DT	denotes	the
T6278	5917-5919	IN	denotes	of
T6277	5908-5916	NN	denotes	kinetics
T6276	5904-5907	DT	denotes	the
T6275	5894-5903	VB	denotes	confirmed
T6274	5891-5893	PRP	denotes	We
T6273	5888-5889	-RRB-	denotes	)
T6272	5885-5888	NN	denotes	S3C
T6271	5880-5884	NN	denotes	Fig.
T6270	5879-5880	-LRB-	denotes	(
T6269	5863-5878	NN	denotes	phosphorylation
T6268	5860-5862	IN	denotes	in
T6267	5851-5859	NN	denotes	increase
T6266	5841-5850	JJ	denotes	transient
T6265	5839-5840	-COMMA-	denotes	,
T6264	5834-5839	JJ	denotes	early
T6263	5831-5833	DT	denotes	an
T6262	5824-5830	RB	denotes	solely
T6261	5817-5823	VB	denotes	caused
T6260	5811-5816	RB	denotes	alone
T6259	5807-5810	NN	denotes	IGF
T6258	5801-5806	IN	denotes	while
T6257	5799-5800	-COMMA-	denotes	,
T6256	5796-5799	NNP	denotes	Akt
T6255	5793-5795	IN	denotes	on
T6254	5777-5792	NN	denotes	phosphorylation
T6253	5770-5776	NN	denotes	Thr308
T6252	5767-5769	IN	denotes	in
T6251	5758-5766	NN	denotes	increase
T6250	5750-5757	VB	denotes	delayed
T6249	5748-5749	DT	denotes	a
T6248	5739-5747	VB	denotes	produced
T6247	5737-5738	-COMMA-	denotes	,
T6246	5727-5737	NN	denotes	conditions
T6245	5722-5726	JJ	denotes	free
T6244	5716-5721	NN	denotes	serum
T6243	5710-5715	IN	denotes	under
T6242	5704-5709	NN	denotes	death
T6241	5699-5703	NN	denotes	cell
T6240	5690-5698	VB	denotes	promoted
T6239	5685-5689	RB	denotes	also
T6238	5679-5684	WDT	denotes	which
T6237	5677-5678	-COMMA-	denotes	,
T6236	5669-5677	NN	denotes	IGF/zVAD
T6235	5667-5668	-COMMA-	denotes	,
T6234	5658-5667	RB	denotes	Similarly
T6233	5016-5017	-RRB-	denotes	)
T6232	5014-5016	NN	denotes	3C
T6231	5009-5013	NN	denotes	Fig.
T6230	5008-5009	-LRB-	denotes	(
T6229	4996-5007	NN	denotes	stimulation
T6228	4989-4995	NN	denotes	factor
T6227	4982-4988	NN	denotes	growth
T6226	4979-4981	TO	denotes	to
T6225	4970-4978	NN	denotes	response
T6224	4961-4969	JJ	denotes	expected
T6223	4957-4960	DT	denotes	the
T6222	4946-4956	VB	denotes	reflecting
T6221	4944-4945	-COMMA-	denotes	,
T6220	4937-4944	NN	denotes	minutes
T6219	4934-4936	CD	denotes	15
T6218	4931-4933	IN	denotes	at
T6217	4925-4930	NN	denotes	c-Jun
T6216	4921-4924	CC	denotes	and
T6215	4917-4920	NN	denotes	JNK
T6214	4914-4916	IN	denotes	as
T6213	4909-4913	RB	denotes	well
T6212	4906-4908	RB	denotes	as
T6211	4902-4905	NN	denotes	Akt
T6210	4899-4901	IN	denotes	of
T6209	4883-4898	NN	denotes	phosphorylation
T6208	4876-4882	NN	denotes	Ser473
T6207	4872-4875	CC	denotes	and
T6206	4865-4871	NN	denotes	Thr308
T6205	4860-4864	CC	denotes	both
T6204	4857-4859	IN	denotes	in
T6203	4848-4856	NN	denotes	increase
T6202	4838-4847	JJ	denotes	transient
T6201	4834-4837	CC	denotes	and
T6200	4828-4833	JJ	denotes	rapid
T6199	4816-4827	JJ	denotes	substantial
T6198	4814-4815	DT	denotes	a
T6197	4811-4813	TO	denotes	to
T6196	4807-4810	VB	denotes	led
T6195	4798-4806	NN	denotes	zVAD.fmk
T6194	4793-4797	IN	denotes	with
T6193	4781-4792	NN	denotes	combination
T6192	4778-4780	IN	denotes	in
T6191	4775-4777	CC	denotes	or
T6190	4769-4774	RB	denotes	alone
T6189	4764-4768	NN	denotes	bFGF
T6188	4761-4763	IN	denotes	of
T6187	4752-4760	NN	denotes	addition
T6186	4748-4751	DT	denotes	the
T6185	4743-4747	IN	denotes	that
T6184	4737-4742	VB	denotes	found
T6183	4734-4736	PRP	denotes	We
T6182	4722-4732	NN	denotes	conditions
T6181	4717-4721	JJ	denotes	free
T6180	4711-4716	NN	denotes	serum
T6179	4705-4710	IN	denotes	under
T6178	4697-4704	NN	denotes	changes
T6177	4681-4696	NN	denotes	phosphorylation
T6176	4675-4680	DT	denotes	these
T6175	4672-4674	IN	denotes	of
T6174	4665-4671	NN	denotes	course
T6173	4660-4664	NN	denotes	time
T6172	4656-4659	DT	denotes	the
T6171	4647-4655	VB	denotes	analyzed
T6170	4642-4646	RB	denotes	next
T6169	4639-4641	PRP	denotes	we
T6168	4637-4638	-COMMA-	denotes	,
T6167	4634-4637	NN	denotes	Akt
T6166	4631-4633	IN	denotes	of
T6165	4620-4630	NN	denotes	regulation
T6164	4608-4619	JJ	denotes	necroptotic
T6163	4605-4607	TO	denotes	to
T6162	4598-4604	NN	denotes	kinase
T6161	4593-4597	NN	denotes	RIP1
T6160	4589-4592	CC	denotes	and
T6159	4581-4588	NN	denotes	factors
T6158	4574-4580	NN	denotes	growth
T6157	4571-4573	IN	denotes	of
T6156	4557-4570	NN	denotes	contributions
T6155	4553-4556	DT	denotes	the
T6154	4542-4552	VB	denotes	understand
T6153	4535-4541	RB	denotes	better
T6152	4532-4534	TO	denotes	To
T6151	4529-4530	-RRB-	denotes	)
T6150	4526-4529	NN	denotes	S3A
T6149	4521-4525	NNP	denotes	Fig.
T6148	4520-4521	-LRB-	denotes	(
T6147	4503-4519	NN	denotes	post-stimulation
T6146	4500-4502	NN	denotes	hr
T6145	4498-4499	CD	denotes	6
T6144	4495-4497	IN	denotes	at
T6143	4483-4494	NN	denotes	necroptosis
T6142	4480-4482	IN	denotes	of
T6141	4474-4479	NN	denotes	onset
T6140	4470-4473	DT	denotes	the
T6139	4465-4469	IN	denotes	with
T6138	4456-4464	VB	denotes	coincide
T6137	4451-4455	WDT	denotes	that
T6136	4449-4450	-RRB-	denotes	)
T6135	4447-4449	NN	denotes	3B
T6134	4442-4446	NN	denotes	Fig.
T6133	4441-4442	-LRB-	denotes	(
T6132	4429-4440	NN	denotes	stimulation
T6131	4420-4428	NN	denotes	zVAD.fmk
T6130	4410-4419	VB	denotes	following
T6129	4403-4409	NN	denotes	events
T6128	4398-4402	JJ	denotes	late
T6127	4394-4397	VB	denotes	are
T6126	4390-4393	NN	denotes	Jun
T6125	4386-4389	CC	denotes	and
T6124	4382-4385	NN	denotes	JNK
T6123	4380-4381	-COMMA-	denotes	,
T6122	4374-4380	NN	denotes	Thr308
T6121	4370-4373	NNP	denotes	Akt
T6120	4367-4369	IN	denotes	of
T6119	4351-4366	NN	denotes	phosphorylation
T6118	4347-4350	DT	denotes	the
T6117	4342-4346	IN	denotes	that
T6116	4331-4341	VB	denotes	discovered
T6115	4328-4330	PRP	denotes	we
T6114	4326-4327	-COMMA-	denotes	,
T6113	4313-4326	RB	denotes	Interestingly
T6112	4302-4311	JJ	denotes	dependent
T6111	4297-4301	NN	denotes	RIP1
T6110	4294-4296	VB	denotes	is
T6109	4282-4293	NN	denotes	necroptosis
T6108	4275-4281	IN	denotes	during
T6107	4259-4274	NN	denotes	phosphorylation
T6106	4255-4258	NN	denotes	JNK
T6105	4251-4254	CC	denotes	and
T6060	3980-3983	CC	denotes	and
T6059	3976-3979	NN	denotes	JNK
T6058	3973-3975	IN	denotes	of
T6057	3966-3972	NN	denotes	levels
T6056	3958-3965	NN	denotes	protein
T6055	3952-3957	JJ	denotes	total
T6054	3949-3951	IN	denotes	in
T6053	3941-3948	NN	denotes	changes
T6052	3936-3940	DT	denotes	some
T6051	3927-3935	VB	denotes	observed
T6050	3924-3926	PRP	denotes	We
T6049	3914-3922	NN	denotes	addition
T6048	3909-3913	NN	denotes	TNFα
T6047	3903-3908	IN	denotes	after
T6046	3896-3902	NN	denotes	change
T6045	3891-3895	DT	denotes	this
T6044	3883-3890	VB	denotes	reduced
T6043	3869-3882	RB	denotes	substantially
T6042	3865-3868	CC	denotes	and
T6041	3856-3864	NN	denotes	zVAD.fmk
T6040	3853-3855	TO	denotes	to
T6039	3844-3852	NN	denotes	response
T6038	3841-3843	IN	denotes	in
T6037	3825-3840	NN	denotes	phosphorylation
T6036	3821-3824	NN	denotes	JNK
T6035	3818-3820	IN	denotes	of
T6034	3808-3817	NN	denotes	induction
T6033	3804-3807	DT	denotes	the
T6032	3794-3803	VB	denotes	prevented
T6031	3788-3793	NN	denotes	Nec-1
T6030	3786-3787	-COMMA-	denotes	,
T6029	3777-3786	RB	denotes	Similarly
T6028	3774-3775	-RRB-	denotes	)
T6027	3771-3774	NN	denotes	S1D
T6026	3766-3770	NNP	denotes	Fig.
T6025	3764-3765	-COMMA-	denotes	,
T6024	3762-3764	NNP	denotes	3A
T6023	3757-3761	NNP	denotes	Fig.
T6022	3756-3757	-LRB-	denotes	(
T6021	3752-3755	RB	denotes	not
T6020	3748-3751	VB	denotes	did
T6019	3741-3747	NN	denotes	Nec-1i
T6018	3735-3740	IN	denotes	while
T6017	3733-3734	-COMMA-	denotes	,
T6016	3718-3733	NN	denotes	phosphorylation
T6015	3714-3717	NN	denotes	Akt
T6014	3707-3713	NN	denotes	Thr308
T6013	3704-3706	IN	denotes	in
T6012	3695-3703	NN	denotes	increase
T6011	3691-3694	DT	denotes	the
T6010	3681-3690	VB	denotes	prevented
T6009	3670-3680	RB	denotes	completely
T6008	3668-3669	-COMMA-	denotes	,
T6007	3663-3668	NN	denotes	Nec-1
T6006	3661-3662	-COMMA-	denotes	,
T6005	3652-3661	NN	denotes	inhibitor
T6004	3645-3651	NN	denotes	kinase
T6003	3640-3644	NN	denotes	RIP1
T6002	3636-3639	DT	denotes	The
T6001	3059-3069	NN	denotes	conditions
T6000	3047-3058	JJ	denotes	necroptotic
T5999	3041-3046	IN	denotes	under
T5998	3031-3040	VB	denotes	activated
T5997	3027-3030	VB	denotes	are
T5996	3023-3026	NN	denotes	JNK
T5995	3019-3022	CC	denotes	and
T5994	3015-3018	NN	denotes	Akt
T5993	3010-3014	CC	denotes	both
T5992	3005-3009	IN	denotes	that
T5991	2996-3004	VB	denotes	indicate
T5990	2991-2995	NN	denotes	data
T5989	2985-2990	DT	denotes	These
T5988	2982-2983	-RRB-	denotes	)
T5987	2980-2982	NN	denotes	3A
T5986	2975-2979	NN	denotes	Fig.
T5985	2974-2975	-LRB-	denotes	(
T5984	2968-2973	NN	denotes	c-Jun
T5983	2958-2967	NN	denotes	substrate
T5982	2952-2957	JJ	denotes	major
T5981	2948-2951	PRP-DOLLAR-	denotes	its
T5980	2944-2947	CC	denotes	and
T5979	2940-2943	NN	denotes	JNK
T5978	2937-2939	IN	denotes	of
T5977	2928-2936	NN	denotes	isoforms
T5976	2924-2927	NN	denotes	p54
T5975	2920-2923	CC	denotes	and
T5974	2916-2919	NN	denotes	p46
T5973	2912-2915	DT	denotes	the
T5972	2907-2911	CC	denotes	both
T5971	2904-2906	IN	denotes	of
T5970	2888-2903	NN	denotes	phosphorylation
T5969	2884-2887	DT	denotes	the
T5968	2881-2883	IN	denotes	in
T5967	2872-2880	NN	denotes	increase
T5966	2869-2871	DT	denotes	an
T5965	2860-2868	VB	denotes	observed
T5964	2855-2859	RB	denotes	also
T5963	2852-2854	PRP	denotes	We
T5962	2844-2850	NN	denotes	Ser473
T5961	2842-2843	-COMMA-	denotes	,
T5960	2839-2842	NN	denotes	Akt
T5959	2836-2838	IN	denotes	of
T5958	2831-2835	NN	denotes	site
T5957	2820-2830	NN	denotes	activation
T5956	2814-2819	JJ	denotes	major
T5955	2807-2813	JJ	denotes	second
T5954	2803-2806	DT	denotes	the
T5953	2800-2802	IN	denotes	in
T5952	2792-2799	NN	denotes	changes
T5951	2776-2791	NN	denotes	phosphorylation
T5950	2764-2775	JJ	denotes	concomitant
T5949	2756-2763	VB	denotes	observe
T5948	2752-2755	RB	denotes	not
T5947	2748-2751	VB	denotes	did
T5946	2745-2747	PRP	denotes	we
T5945	2743-2744	-COMMA-	denotes	,
T5944	2730-2743	RB	denotes	Interestingly
T5943	2727-2728	-RRB-	denotes	)
T5942	2725-2727	NN	denotes	3A
T5941	2720-2724	NN	denotes	Fig.
T5940	2719-2720	-LRB-	denotes	(
T5939	2712-2718	NN	denotes	Thr308
T5938	2710-2711	-COMMA-	denotes	,
T5937	2706-2710	NN	denotes	site
T5936	2695-2705	NN	denotes	activation
T5935	2689-2694	JJ	denotes	major
T5934	2683-2688	JJ	denotes	known
T5933	2681-2682	DT	denotes	a
T5932	2678-2680	IN	denotes	at
T5931	2662-2677	NN	denotes	phosphorylation
T5930	2658-2661	NN	denotes	Akt
T5929	2655-2657	IN	denotes	in
T5928	2646-2654	NN	denotes	increase
T5927	2639-2645	JJ	denotes	robust
T5926	2637-2638	DT	denotes	a
T5925	2628-2636	VB	denotes	observed
T5924	2625-2627	PRP	denotes	we
T5923	2620-2624	NN	denotes	TNFα
T5922	2617-2619	CC	denotes	or
T5921	2608-2616	NN	denotes	zVAD.fmk
T5920	2601-2607	CC	denotes	either
T5919	2596-2600	IN	denotes	with
T5918	2584-2595	NN	denotes	stimulation
T5917	2574-2583	VB	denotes	Following
T5916	2571-2572	-RRB-	denotes	)
T5915	2570-2571	NN	denotes	B
T5914	2568-2569	-COMMA-	denotes	,
T5913	2565-2568	NN	denotes	S3A
T5912	2560-2564	NNP	denotes	Fig.
T5911	2559-2560	-LRB-	denotes	(
T5910	2552-2558	NN	denotes	system
T5909	2548-2551	PRP-DOLLAR-	denotes	our
T5908	2545-2547	IN	denotes	in
T5907	2539-2544	NN	denotes	death
T5906	2534-2538	NN	denotes	cell
T5905	2531-2533	IN	denotes	of
T5904	2525-2530	NN	denotes	stage
T5903	2519-2524	JJ	denotes	early
T5902	2515-2518	DT	denotes	the
T5901	2506-2514	VB	denotes	reflects
T5900	2503-2505	PRP	denotes	it
T5899	2495-2502	IN	denotes	because
T5898	2488-2494	VB	denotes	chosen
T5897	2484-2487	VB	denotes	was
T5896	2478-2483	NN	denotes	point
T5895	2473-2477	NN	denotes	time
T5894	2468-2472	DT	denotes	This
T5893	2455-2466	NN	denotes	stimulation
T5892	2450-2454	NN	denotes	TNFα
T5891	2446-2449	CC	denotes	and
T5890	2437-2445	NN	denotes	zVAD.fmk
T5889	2432-2436	IN	denotes	post
T5888	2428-2431	NN	denotes	hrs
T5887	2426-2427	CD	denotes	9
T5886	2423-2425	IN	denotes	at
T5885	2407-2422	NN	denotes	phosphorylation
T5884	2403-2406	NN	denotes	JNK
T5883	2399-2402	CC	denotes	and
T5882	2395-2398	NN	denotes	Akt
T5881	2392-2394	IN	denotes	in
T5880	2384-2391	NN	denotes	changes
T5879	2380-2383	DT	denotes	the
T5878	2371-2379	VB	denotes	examined
T5877	2368-2370	PRP	denotes	we
T5876	2366-2367	-COMMA-	denotes	,
T5875	2356-2366	NN	denotes	conditions
T5874	2344-2355	JJ	denotes	necroptotic
T5873	2338-2343	IN	denotes	under
T5872	2334-2337	NN	denotes	JNK
T5871	2330-2333	CC	denotes	and
T5863	2282-2286	NN	denotes	L929
T6344	6349-6355	NN	denotes	kinase
T6343	6344-6348	NN	denotes	RIP1
T6342	6339-6343	IN	denotes	from
T6341	6328-6338	RB	denotes	downstream
T6340	6318-6327	NN	denotes	signaling
T6339	6306-6317	JJ	denotes	necroptotic
T6338	6303-6305	IN	denotes	of
T6337	6290-6302	NN	denotes	consequences
T6336	6281-6289	JJ	denotes	specific
T6335	6271-6280	VB	denotes	represent
T6334	6269-6270	-COMMA-	denotes	,
T6333	6264-6269	NN	denotes	death
T6332	6259-6263	NN	denotes	cell
T6331	6256-6258	IN	denotes	of
T6330	6250-6255	NN	denotes	onset
T6329	6246-6249	DT	denotes	the
T6328	6236-6245	VB	denotes	preceding
T6327	6234-6235	-COMMA-	denotes	,
T6326	6219-6234	NN	denotes	phosphorylation
T6325	6215-6218	NN	denotes	JNK
T6324	6211-6214	CC	denotes	and
T6323	6207-6210	NN	denotes	Akt
T6322	6204-6206	IN	denotes	in
T6321	6194-6203	NN	denotes	increases
T5870	2326-2329	NN	denotes	Akt
T5869	2323-2325	IN	denotes	of
T5868	2312-2322	NN	denotes	activation
T5867	2308-2311	DT	denotes	the
T5866	2297-2307	VB	denotes	understand
T5865	2294-2296	TO	denotes	To
T5864	2287-2292	NN	denotes	cells
T5862	2279-2281	IN	denotes	in
T5861	2271-2278	NN	denotes	stimuli
T5860	2262-2270	JJ	denotes	multiple
T5859	2259-2261	IN	denotes	by
T5858	2251-2258	VB	denotes	induced
T5857	2239-2250	NN	denotes	necroptosis
T5856	2236-2238	IN	denotes	in
T5855	2231-2235	NN	denotes	role
T5854	2227-2230	JJ	denotes	key
T5853	2225-2226	DT	denotes	a
T5852	2219-2224	VB	denotes	plays
T5851	2215-2218	NN	denotes	Akt
T5850	2210-2214	IN	denotes	that
T5849	2200-2209	VB	denotes	confirmed
T5848	2192-2199	NN	denotes	results
T5847	2188-2191	PRP-DOLLAR-	denotes	Our
T5846	2175-2186	NN	denotes	necroptosis
T5845	2172-2174	IN	denotes	on
T5584	211-215	NN	denotes	MAPK
T5583	201-210	VB	denotes	including
T5582	199-200	-COMMA-	denotes	,
T5581	191-199	NN	denotes	pathways
T5580	183-190	JJ	denotes	several
T5579	180-182	IN	denotes	of
T5578	167-179	NN	denotes	contribution
T5577	163-166	DT	denotes	the
T5576	154-162	VB	denotes	examined
T5575	151-153	PRP	denotes	we
T5574	149-150	-COMMA-	denotes	,
T5573	144-149	NN	denotes	death
T5572	136-143	VB	denotes	induced
T5571	127-135	NN	denotes	zVAD.fmk
T5570	123-126	IN	denotes	for
T5569	113-122	JJ	denotes	important
T5568	109-112	VB	denotes	are
T5567	101-108	NN	denotes	factors
T5566	94-100	NN	denotes	growth
T5565	89-93	IN	denotes	that
T5564	77-88	NN	denotes	observation
T5563	73-76	PRP-DOLLAR-	denotes	our
T5562	67-72	VB	denotes	Given
T5561	55-66	NN	denotes	Necroptosis
T5560	52-54	TO	denotes	to
T5559	40-51	NNP	denotes	Contributes
T5558	36-39	NNP	denotes	Akt
T5557	33-35	IN	denotes	of
T5556	22-32	NN	denotes	Activation
T6081	4120-4131	RB	denotes	Importantly
T6104	4244-4250	NN	denotes	Thr308
T6103	4240-4243	NN	denotes	Akt
T6102	4235-4239	IN	denotes	that
T6101	4223-4234	VB	denotes	established
T6100	4218-4222	DT	denotes	This
T6099	4215-4216	-RRB-	denotes	)
T6098	4213-4215	NN	denotes	3A
T6097	4208-4212	NN	denotes	Fig.
T6096	4207-4208	-LRB-	denotes	(
T6095	4203-4206	NN	denotes	JNK
T6094	4200-4202	CC	denotes	or
T6093	4196-4199	NN	denotes	Akt
T6092	4189-4195	CC	denotes	either
T6091	4186-4188	IN	denotes	of
T6090	4179-4185	NN	denotes	levels
T6089	4163-4178	NN	denotes	phosphorylation
T6088	4157-4162	JJ	denotes	basal
T6087	4153-4156	DT	denotes	the
T6086	4147-4152	VB	denotes	alter
T6085	4143-4146	RB	denotes	not
T6084	4139-4142	VB	denotes	did
T6083	4133-4138	NN	denotes	Nec-1
T6082	4131-4132	-COMMA-	denotes	,
T6080	4113-4118	NN	denotes	Nec-1
T6079	4110-4112	IN	denotes	by
T6078	4099-4109	VB	denotes	attenuated
T6077	4094-4098	RB	denotes	also
T6076	4089-4093	VB	denotes	were
T6075	4087-4088	-COMMA-	denotes	,
T6074	4082-4087	NN	denotes	c-Jun
T6073	4079-4081	IN	denotes	in
T6072	4070-4078	NN	denotes	increase
T6071	4053-4069	JJ	denotes	zVAD.fmk-induced
T6070	4048-4052	FW	denotes	e.g.
T6069	4046-4047	-COMMA-	denotes	,
T6068	4039-4046	NN	denotes	changes
T6067	4033-4038	DT	denotes	these
T6066	4030-4032	IN	denotes	of
T6065	4025-4029	DT	denotes	Some
T6064	4012-4023	NN	denotes	stimulation
T6063	4000-4011	JJ	denotes	necroptotic
T6062	3990-3999	VB	denotes	following
T6061	3984-3989	NN	denotes	c-Jun
T5844	2165-2171	NN	denotes	effect
T5843	2154-2164	JJ	denotes	additional
T5842	2151-2153	DT	denotes	no
T5841	2147-2150	VB	denotes	had
T5840	2141-2146	NN	denotes	siRNA
T5839	2136-2140	NN	denotes	Akt3
T5838	2134-2135	-COMMA-	denotes	,
T5837	2122-2134	RB	denotes	consistently
T5836	2120-2121	-COMMA-	denotes	,
T5835	2117-2120	CC	denotes	and
T5834	2115-2116	-RRB-	denotes	)
T5833	2112-2115	NN	denotes	S2C
T5832	2107-2111	NN	denotes	Fig.
T5831	2106-2107	-LRB-	denotes	(
T5830	2100-2105	NN	denotes	cells
T5829	2095-2099	NN	denotes	L929
T5828	2092-2094	IN	denotes	in
T5827	2087-2091	VB	denotes	seen
T5826	2083-2086	VB	denotes	was
T5825	2078-2082	NN	denotes	Akt3
T5824	2075-2077	IN	denotes	of
T5823	2064-2074	NN	denotes	expression
T5822	2061-2063	DT	denotes	No
T5821	2058-2059	-RRB-	denotes	)
T5820	2056-2058	NN	denotes	2C
T5819	2051-2055	NN	denotes	Fig.
T5818	2050-2051	-LRB-	denotes	(
T5817	2045-2049	NN	denotes	TNFα
T5816	2041-2044	CC	denotes	and
T5815	2032-2040	NN	denotes	zVAD.fmk
T5814	2027-2031	CC	denotes	both
T5813	2024-2026	IN	denotes	by
T5812	2016-2023	VB	denotes	induced
T5811	2004-2015	NN	denotes	necroptosis
T5810	1999-2003	IN	denotes	from
T5809	1993-1998	NN	denotes	cells
T5808	1983-1992	VB	denotes	protected
T5807	1976-1982	NN	denotes	siRNAs
T5806	1970-1975	VB	denotes	using
T5805	1965-1969	NN	denotes	Akt2
T5804	1961-1964	CC	denotes	and
T5803	1956-1960	NN	denotes	Akt1
T5802	1947-1955	NN	denotes	isoforms
T5801	1943-1946	NN	denotes	Akt
T5800	1940-1942	IN	denotes	of
T5799	1930-1939	NN	denotes	knockdown
T5798	1917-1929	JJ	denotes	simultaneous
T5774	1812-1813	-LRB-	denotes	(
T5773	1800-1811	NN	denotes	triciribine
T5772	1796-1799	CC	denotes	and
T5771	1794-1795	-RRB-	denotes	]
T5770	1792-1794	CD	denotes	25
T5769	1791-1792	-LRB-	denotes	[
T5768	1783-1790	NN	denotes	MK-2206
T5767	1773-1782	NN	denotes	inhibitor
T5766	1766-1772	NN	denotes	kinase
T5765	1755-1765	JJ	denotes	allosteric
T5764	1753-1754	-COMMA-	denotes	,
T5763	1745-1753	JJ	denotes	specific
T5762	1738-1744	RB	denotes	highly
T5761	1736-1737	DT	denotes	a
T5760	1734-1735	-COMMA-	denotes	,
T5759	1724-1734	NN	denotes	inhibitors
T5758	1720-1723	NN	denotes	Akt
T5757	1709-1719	JJ	denotes	additional
T5756	1705-1708	CD	denotes	two
T5755	1703-1704	-COMMA-	denotes	,
T5754	1698-1703	RB	denotes	First
T5753	1691-1696	NN	denotes	death
T5752	1686-1690	NN	denotes	cell
T5751	1674-1685	JJ	denotes	necroptotic
T5750	1671-1673	IN	denotes	in
T5749	1667-1670	NN	denotes	Akt
T5748	1664-1666	IN	denotes	of
T5747	1659-1663	NN	denotes	role
T5746	1655-1658	DT	denotes	the
T5745	1646-1654	VB	denotes	validate
T5744	1638-1645	RB	denotes	further
T5743	1635-1637	TO	denotes	to
T5742	1624-1634	NN	denotes	approaches
T5741	1620-1623	CD	denotes	two
T5740	1615-1619	VB	denotes	used
T5739	1612-1614	PRP	denotes	we
T5738	1610-1611	-COMMA-	denotes	,
T5737	1606-1610	RB	denotes	Next
T5736	1010-1011	-RRB-	denotes	)
T5735	1008-1010	NN	denotes	2A
T5734	1003-1007	NN	denotes	Fig.
T5733	1002-1003	-LRB-	denotes	(
T5732	996-1001	NN	denotes	death
T5731	988-995	VB	denotes	induced
T5730	983-987	NN	denotes	TNFα
T5729	980-982	CC	denotes	or
T5728	971-979	NN	denotes	zVAD.fmk
T5727	964-970	CC	denotes	either
T5726	959-963	IN	denotes	from
T5725	951-958	VB	denotes	protect
T5724	947-950	RB	denotes	not
T5723	943-946	VB	denotes	did
T5722	941-942	-COMMA-	denotes	,
T5721	940-941	-RRB-	denotes	]
T5720	938-940	CD	denotes	14
T5719	937-938	-LRB-	denotes	[
T5718	925-936	NN	denotes	necroptosis
T5717	918-924	IN	denotes	during
T5716	908-917	VB	denotes	activated
T5715	905-907	VB	denotes	be
T5714	902-904	TO	denotes	to
T5713	898-901	RB	denotes	not
T5712	889-897	VB	denotes	reported
T5711	878-888	RB	denotes	previously
T5710	876-877	-COMMA-	denotes	,
T5709	873-876	NN	denotes	ERK
T5708	869-872	CC	denotes	and
T5707	865-868	NN	denotes	p38
T5706	863-864	-COMMA-	denotes	,
T5705	858-863	NN	denotes	MAPKs
T5704	852-857	JJ	denotes	other
T5703	848-851	CD	denotes	two
T5702	845-847	IN	denotes	of
T5701	834-844	NN	denotes	inhibition
T5700	832-833	-COMMA-	denotes	,
T5699	824-832	NN	denotes	contrast
T5698	821-823	IN	denotes	In
T5697	818-819	-RRB-	denotes	]
T5696	816-818	CD	denotes	14
T5695	815-816	-LRB-	denotes	[
T5694	813-814	-COMMA-	denotes	,
T5693	812-813	-RRB-	denotes	]
T5692	810-812	CD	denotes	12
T5691	809-810	-LRB-	denotes	[
T5690	807-808	-RRB-	denotes	)
T5689	804-807	NN	denotes	S2A
T5688	799-803	NNP	denotes	Fig.
T5687	795-798	CC	denotes	and
T5686	793-794	NN	denotes	B
T5685	792-793	-COMMA-	denotes	,
T5684	790-792	NN	denotes	2A
T5683	785-789	NNP	denotes	Fig.
T5682	784-785	-LRB-	denotes	(
T5681	778-783	NN	denotes	death
T5680	770-777	VB	denotes	induced
T5679	765-769	NN	denotes	TNFα
T5678	761-764	CC	denotes	and
T5677	752-760	NN	denotes	zVAD.fmk
T5676	747-751	CC	denotes	both
T5675	742-746	IN	denotes	from
T5674	736-741	NN	denotes	cells
T5673	732-735	DT	denotes	the
T5672	722-731	VB	denotes	protected
T5671	713-721	NN	denotes	SP600125
T5670	703-712	NN	denotes	inhibitor
T5669	699-702	NN	denotes	JNK
T5668	695-698	DT	denotes	the
T5667	693-694	-COMMA-	denotes	,
T5666	686-693	NN	denotes	reports
T5665	677-685	JJ	denotes	previous
T5664	672-676	IN	denotes	with
T5663	661-671	JJ	denotes	Consistent
T5662	658-659	-RRB-	denotes	)
T5661	656-658	NN	denotes	2A
T5660	651-655	NN	denotes	Fig.
T5659	650-651	-LRB-	denotes	(
T5658	645-649	NN	denotes	TNFα
T5657	642-644	IN	denotes	by
T5656	635-641	VB	denotes	caused
T5655	632-634	IN	denotes	by
T5654	626-631	NN	denotes	death
T5653	614-625	JJ	denotes	insensitive
T5652	600-613	NN	denotes	growth-factor
T5651	595-599	IN	denotes	from
T5650	589-594	NN	denotes	cells
T5649	585-588	DT	denotes	the
T5648	575-584	VB	denotes	protected
T5647	570-574	RB	denotes	also
T5646	566-569	NN	denotes	Akt
T5645	563-565	IN	denotes	of
T5644	552-562	NN	denotes	Inhibition
T5643	549-550	-RRB-	denotes	)
T5642	547-549	NN	denotes	2B
T5641	542-546	NN	denotes	Fig.
T5640	541-542	-LRB-	denotes	(
T5639	530-540	NN	denotes	conditions
T5638	525-529	JJ	denotes	free
T5637	519-524	NN	denotes	serum
T5636	513-518	IN	denotes	under
T5635	498-512	NN	denotes	IGF-1/zVAD.fmk
T5634	495-497	CC	denotes	or
T5633	490-494	NN	denotes	bFGF
T5632	487-489	IN	denotes	by
T5631	477-486	VB	denotes	triggered
T5630	471-476	NN	denotes	death
T5629	466-470	NN	denotes	cell
T5628	463-465	IN	denotes	as
T5627	458-462	RB	denotes	well
T5626	455-457	RB	denotes	as
T5625	453-454	-RRB-	denotes	]
T5624	451-453	CD	denotes	16
T5623	450-451	-LRB-	denotes	[
T5622	441-449	NN	denotes	zVAD.fmk
T5621	438-440	IN	denotes	by
T5620	430-437	VB	denotes	induced
T5619	418-429	NN	denotes	necroptosis
T5618	401-417	JJ	denotes	factor-sensitive
T5617	394-400	NN	denotes	growth
T5616	389-393	IN	denotes	from
T5615	383-388	NN	denotes	cells
T5614	379-382	DT	denotes	the
T5613	369-378	VB	denotes	protected
T5612	360-368	RB	denotes	strongly
T5611	358-359	-RRB-	denotes	)
T5610	354-358	CD	denotes	VIII
T5609	344-353	NN	denotes	inhibitor
T5608	340-343	NN	denotes	Akt
T5607	339-340	-LRB-	denotes	(
T5606	335-338	NN	denotes	Akt
T5605	332-334	IN	denotes	of
T5604	321-331	NN	denotes	Inhibition
T5603	318-319	-RRB-	denotes	)
T5602	316-318	NN	denotes	2A
T5601	311-315	NN	denotes	Fig.
T5600	310-311	-LRB-	denotes	(
T5599	299-309	NN	denotes	activation
T5598	290-298	NN	denotes	receptor
T5597	283-289	NN	denotes	factor
T5596	276-282	NN	denotes	growth
T5595	266-275	VB	denotes	following
T5594	256-265	VB	denotes	activated
T5593	253-255	VB	denotes	be
T5592	250-252	TO	denotes	to
T5591	244-249	VB	denotes	known
T5590	240-243	VB	denotes	are
T5589	234-239	WDT	denotes	which
T5588	232-233	-COMMA-	denotes	,
T5587	229-232	NN	denotes	Akt
T5586	225-228	CC	denotes	and
T5585	216-224	NN	denotes	pathways
T5797	1915-1916	-COMMA-	denotes	,
T5796	1907-1915	RB	denotes	Secondly
T5795	1904-1905	-RRB-	denotes	)
T5794	1901-1904	NN	denotes	S2B
T5793	1896-1900	NN	denotes	Fig.
T5792	1895-1896	-LRB-	denotes	(
T5791	1889-1894	NN	denotes	death
T5790	1884-1888	NN	denotes	cell
T5789	1873-1883	VB	denotes	attenuated
T5788	1868-1872	DT	denotes	both
T5787	1866-1867	-COMMA-	denotes	,
T5786	1863-1866	NN	denotes	Akt
T5785	1860-1862	IN	denotes	of
T5784	1846-1859	NN	denotes	translocation
T5783	1837-1845	NN	denotes	membrane
T5782	1830-1836	VB	denotes	blocks
T5781	1824-1829	WDT	denotes	which
T5780	1822-1823	-COMMA-	denotes	,
T5779	1821-1822	-RRB-	denotes	]
T5778	1819-1821	CD	denotes	26
T5777	1818-1819	-LRB-	denotes	[
T5776	1816-1817	-RRB-	denotes	)
T5775	1813-1816	NN	denotes	TCN
R3609	T5556	T5557	arg1Of	Activation,of
R3610	T5556	T5560	arg1Of	Activation,to
R3611	T5559	T5557	arg2Of	Contributes,of
R3612	T5559	T5558	arg1Of	Contributes,Akt
R3613	T5561	T5560	arg2Of	Necroptosis,to
R3614	T5564	T5562	arg2Of	observation,Given
R3615	T5564	T5563	arg1Of	observation,our
R3616	T5567	T5566	arg1Of	factors,growth
R3617	T5567	T5568	arg1Of	factors,are
R3618	T5567	T5569	arg1Of	factors,important
R3619	T5568	T5570	arg1Of	are,for
R3620	T5569	T5568	arg2Of	important,are
R3621	T5570	T5564	arg2Of	for,observation
R3622	T5570	T5565	arg1Of	for,that
R3623	T5571	T5572	arg1Of	zVAD.fmk,induced
R3624	T5572	T5570	arg2Of	induced,for
R3625	T5573	T5572	arg2Of	death,induced
R3626	T5575	T5576	arg1Of	we,examined
R3627	T5576	T5562	arg1Of	examined,Given
R3628	T5576	T5574	arg1Of	examined,","
R3629	T5578	T5576	arg2Of	contribution,examined
R3630	T5578	T5577	arg1Of	contribution,the
R3631	T5578	T5579	arg1Of	contribution,of
R3632	T5581	T5579	arg2Of	pathways,of
R3633	T5581	T5580	arg1Of	pathways,several
R3634	T5581	T5582	arg1Of	pathways,","
R3635	T5581	T5583	arg1Of	pathways,including
R3636	T5585	T5584	arg1Of	pathways,MAPK
R3637	T5585	T5586	arg1Of	pathways,and
R3638	T5586	T5583	arg2Of	and,including
R3639	T5586	T5588	arg1Of	and,","
R3640	T5586	T5589	arg1Of	and,which
R3641	T5586	T5590	arg1Of	and,are
R3642	T5586	T5591	arg2Of	and,known
R3643	T5586	T5593	arg1Of	and,be
R3644	T5586	T5594	arg2Of	and,activated
R3645	T5587	T5586	arg2Of	Akt,and
R3646	T5591	T5590	arg2Of	known,are
R3647	T5594	T5591	arg3Of	activated,known
R3648	T5594	T5592	arg1Of	activated,to
R3649	T5594	T5593	arg2Of	activated,be
R3650	T5594	T5595	arg1Of	activated,following
R3651	T5599	T5595	arg2Of	activation,following
R3652	T5599	T5596	arg1Of	activation,growth
R3653	T5599	T5597	arg1Of	activation,factor
R3654	T5599	T5598	arg1Of	activation,receptor
R3655	T5599	T5600	arg1Of	activation,(
R3656	T5602	T5600	arg2Of	2A,(
R3657	T5602	T5601	arg1Of	2A,Fig.
R3658	T5603	T5600	arg3Of	),(
R3659	T5604	T5605	arg1Of	Inhibition,of
R3660	T5604	T5613	arg1Of	Inhibition,protected
R3661	T5606	T5605	arg2Of	Akt,of
R3662	T5606	T5607	arg1Of	Akt,(
R3663	T5609	T5607	arg2Of	inhibitor,(
R3664	T5609	T5608	arg1Of	inhibitor,Akt
R3665	T5609	T5610	arg1Of	inhibitor,VIII
R3666	T5611	T5607	arg3Of	),(
R3667	T5613	T5612	arg1Of	protected,strongly
R3668	T5615	T5613	arg2Of	cells,protected
R3669	T5615	T5614	arg1Of	cells,the
R3670	T5615	T5616	arg1Of	cells,from
R3671	T5619	T5617	arg1Of	necroptosis,growth
R3672	T5619	T5618	arg1Of	necroptosis,factor-sensitive
R3673	T5619	T5620	arg2Of	necroptosis,induced
R3674	T5619	T5628	arg1Of	necroptosis,as
R3675	T5620	T5623	arg1Of	induced,[
R3676	T5622	T5620	arg1Of	zVAD.fmk,induced
R3677	T5622	T5621	arg2Of	zVAD.fmk,by
R3678	T5624	T5623	arg2Of	16,[
R3679	T5625	T5623	arg3Of	],[
R3680	T5628	T5616	arg2Of	as,from
R3681	T5628	T5626	arg1Of	as,as
R3682	T5628	T5627	arg1Of	as,well
R3683	T5630	T5628	arg2Of	death,as
R3684	T5630	T5629	arg1Of	death,cell
R3685	T5630	T5631	arg2Of	death,triggered
R3686	T5631	T5636	arg1Of	triggered,under
R3687	T5633	T5634	arg1Of	bFGF,or
R3688	T5634	T5631	arg1Of	or,triggered
R3689	T5634	T5632	arg2Of	or,by
R3690	T5635	T5634	arg2Of	IGF-1/zVAD.fmk,or
R3691	T5639	T5636	arg2Of	conditions,under
R3692	T5639	T5637	arg1Of	conditions,serum
R3693	T5639	T5638	arg1Of	conditions,free
R3694	T5639	T5640	arg1Of	conditions,(
R3695	T5642	T5640	arg2Of	2B,(
R3696	T5642	T5641	arg1Of	2B,Fig.
R3697	T5643	T5640	arg3Of	),(
R3698	T5644	T5645	arg1Of	Inhibition,of
R3699	T5644	T5648	arg1Of	Inhibition,protected
R3700	T5646	T5645	arg2Of	Akt,of
R3701	T5648	T5647	arg1Of	protected,also
R3702	T5650	T5648	arg2Of	cells,protected
R3703	T5650	T5649	arg1Of	cells,the
R3704	T5650	T5651	arg1Of	cells,from
R3705	T5650	T5656	arg2Of	cells,caused
R3706	T5654	T5651	arg2Of	death,from
R3707	T5654	T5652	arg1Of	death,growth-factor
R3708	T5654	T5653	arg1Of	death,insensitive
R3709	T5654	T5655	arg1Of	death,by
R3710	T5658	T5656	arg1Of	TNFα,caused
R3711	T5658	T5657	arg2Of	TNFα,by
R3712	T5658	T5659	arg1Of	TNFα,(
R3713	T5661	T5659	arg2Of	2A,(
R3714	T5661	T5660	arg1Of	2A,Fig.
R3715	T5662	T5659	arg3Of	),(
R3716	T5663	T5664	arg1Of	Consistent,with
R3717	T5666	T5664	arg2Of	reports,with
R3718	T5666	T5665	arg1Of	reports,previous
R3719	T5671	T5663	arg1Of	SP600125,Consistent
R3720	T5671	T5668	arg1Of	SP600125,the
R3721	T5671	T5669	arg1Of	SP600125,JNK
R3722	T5671	T5670	arg1Of	SP600125,inhibitor
R3723	T5671	T5672	arg1Of	SP600125,protected
R3724	T5672	T5678	arg1Of	protected,and
R3725	T5674	T5672	arg2Of	cells,protected
R3726	T5674	T5673	arg1Of	cells,the
R3727	T5674	T5675	arg1Of	cells,from
R3728	T5677	T5675	arg2Of	zVAD.fmk,from
R3729	T5677	T5676	arg1Of	zVAD.fmk,both
R3730	T5678	T5663	modOf	and,Consistent
R3731	T5678	T5667	arg1Of	and,","
R3732	T5679	T5680	arg1Of	TNFα,induced
R3733	T5680	T5678	arg2Of	induced,and
R3734	T5680	T5691	arg1Of	induced,[
R3735	T5680	T5694	arg1Of	induced,","
R3736	T5680	T5695	arg1Of	induced,[
R3737	T5681	T5680	arg2Of	death,induced
R3738	T5681	T5682	arg1Of	death,(
R3739	T5684	T5685	arg1Of	2A,","
R3740	T5685	T5687	arg1Of	",",and
R3741	T5686	T5685	arg2Of	B,","
R3742	T5687	T5682	arg2Of	and,(
R3743	T5687	T5683	arg1Of	and,Fig.
R3744	T5689	T5687	arg2Of	S2A,and
R3745	T5689	T5688	arg1Of	S2A,Fig.
R3746	T5690	T5682	arg3Of	),(
R3747	T5692	T5691	arg2Of	12,[
R3748	T5693	T5691	arg3Of	],[
R3749	T5696	T5695	arg2Of	14,[
R3750	T5697	T5695	arg3Of	],[
R3751	T5699	T5698	arg2Of	contrast,In
R3752	T5701	T5702	arg1Of	inhibition,of
R3753	T5701	T5725	arg2Of	inhibition,protect
R3754	T5701	T5731	arg1Of	inhibition,induced
R3755	T5705	T5702	arg2Of	MAPKs,of
R3756	T5705	T5703	arg1Of	MAPKs,two
R3757	T5705	T5704	arg1Of	MAPKs,other
R3758	T5705	T5706	arg1Of	MAPKs,","
R3759	T5705	T5710	arg1Of	MAPKs,","
R3760	T5705	T5712	arg2Of	MAPKs,reported
R3761	T5707	T5708	arg1Of	p38,and
R3762	T5708	T5706	arg2Of	and,","
R3763	T5709	T5708	arg2Of	ERK,and
R3764	T5712	T5711	arg1Of	reported,previously
R3765	T5716	T5713	arg1Of	activated,not
R3766	T5716	T5714	arg1Of	activated,to
R3767	T5716	T5715	arg2Of	activated,be
R3768	T5716	T5717	arg1Of	activated,during
R3769	T5716	T5723	arg1Of	activated,did
R3770	T5716	T5725	arg1Of	activated,protect
R3771	T5718	T5717	arg2Of	necroptosis,during
R3772	T5718	T5719	arg1Of	necroptosis,[
R3773	T5720	T5719	arg2Of	14,[
R3774	T5721	T5719	arg3Of	],[
R3775	T5725	T5722	arg1Of	protect,","
R3776	T5725	T5723	arg2Of	protect,did
R3777	T5725	T5724	arg1Of	protect,not
R3778	T5725	T5726	arg1Of	protect,from
R3779	T5728	T5729	arg1Of	zVAD.fmk,or
R3780	T5729	T5726	arg2Of	or,from
R3781	T5729	T5727	arg1Of	or,either
R3782	T5730	T5729	arg2Of	TNFα,or
R3783	T5731	T5698	arg1Of	induced,In
R3784	T5731	T5700	arg1Of	induced,","
R3785	T5732	T5731	arg2Of	death,induced
R3786	T5732	T5733	arg1Of	death,(
R3787	T5735	T5733	arg2Of	2A,(
R3788	T5735	T5734	arg1Of	2A,Fig.
R3789	T5736	T5733	arg3Of	),(
R3790	T5739	T5740	arg1Of	we,used
R3791	T5739	T5745	arg1Of	we,validate
R3792	T5740	T5737	arg1Of	used,Next
R3793	T5740	T5738	arg1Of	used,","
R3794	T5742	T5740	arg2Of	approaches,used
R3795	T5742	T5741	arg1Of	approaches,two
R3796	T5745	T5740	arg3Of	validate,used
R3797	T5745	T5743	arg1Of	validate,to
R3798	T5745	T5744	arg1Of	validate,further
R3799	T5747	T5745	arg2Of	role,validate
R3800	T5747	T5746	arg1Of	role,the
R3801	T5747	T5748	arg1Of	role,of
R3802	T5747	T5750	arg1Of	role,in
R3803	T5749	T5748	arg2Of	Akt,of
R3804	T5753	T5750	arg2Of	death,in
R3805	T5753	T5751	arg1Of	death,necroptotic
R3806	T5753	T5752	arg1Of	death,cell
R3807	T5759	T5756	arg1Of	inhibitors,two
R3808	T5759	T5757	arg1Of	inhibitors,additional
R3809	T5759	T5758	arg1Of	inhibitors,Akt
R3810	T5759	T5760	arg1Of	inhibitors,","
R3811	T5759	T5789	arg1Of	inhibitors,attenuated
R3812	T5763	T5762	arg1Of	specific,highly
R3813	T5763	T5764	arg1Of	specific,","
R3814	T5765	T5764	arg2Of	allosteric,","
R3815	T5768	T5763	arg1Of	MK-2206,specific
R3816	T5768	T5765	arg1Of	MK-2206,allosteric
R3817	T5768	T5766	arg1Of	MK-2206,kinase
R3818	T5768	T5767	arg1Of	MK-2206,inhibitor
R3819	T5768	T5769	arg1Of	MK-2206,[
R3820	T5768	T5772	arg1Of	MK-2206,and
R3821	T5770	T5769	arg2Of	25,[
R3822	T5771	T5769	arg3Of	],[
R3823	T5772	T5760	arg2Of	and,","
R3824	T5772	T5761	arg1Of	and,a
R3825	T5772	T5780	arg1Of	and,","
R3826	T5772	T5781	arg1Of	and,which
R3827	T5772	T5782	arg1Of	and,blocks
R3828	T5773	T5772	arg2Of	triciribine,and
R3829	T5773	T5774	arg1Of	triciribine,(
R3830	T5773	T5777	arg1Of	triciribine,[
R3831	T5775	T5774	arg2Of	TCN,(
R3832	T5776	T5774	arg3Of	),(
R3833	T5778	T5777	arg2Of	26,[
R3834	T5779	T5777	arg3Of	],[
R3835	T5784	T5782	arg2Of	translocation,blocks
R3836	T5784	T5783	arg1Of	translocation,membrane
R3837	T5784	T5785	arg1Of	translocation,of
R3838	T5786	T5785	arg2Of	Akt,of
R3839	T5789	T5754	arg1Of	attenuated,First
R3840	T5789	T5755	arg1Of	attenuated,","
R3841	T5789	T5787	arg1Of	attenuated,","
R3842	T5789	T5788	arg1Of	attenuated,both
R3843	T5791	T5789	arg2Of	death,attenuated
R3844	T5791	T5790	arg1Of	death,cell
R3845	T5791	T5792	arg1Of	death,(
R3846	T5794	T5792	arg2Of	S2B,(
R3847	T5794	T5793	arg1Of	S2B,Fig.
R3848	T5795	T5792	arg3Of	),(
R3849	T5799	T5798	arg1Of	knockdown,simultaneous
R3850	T5799	T5800	arg1Of	knockdown,of
R3851	T5799	T5808	arg1Of	knockdown,protected
R3852	T5802	T5801	arg1Of	isoforms,Akt
R3853	T5803	T5804	arg1Of	Akt1,and
R3854	T5804	T5800	arg2Of	and,of
R3855	T5804	T5802	arg1Of	and,isoforms
R3856	T5804	T5806	arg1Of	and,using
R3857	T5805	T5804	arg2Of	Akt2,and
R3858	T5807	T5806	arg2Of	siRNAs,using
R3859	T5808	T5796	arg1Of	protected,Secondly
R3860	T5808	T5797	arg1Of	protected,","
R3861	T5809	T5808	arg2Of	cells,protected
R3862	T5809	T5810	arg1Of	cells,from
R3863	T5811	T5810	arg2Of	necroptosis,from
R3864	T5811	T5812	arg2Of	necroptosis,induced
R3865	T5815	T5816	arg1Of	zVAD.fmk,and
R3866	T5816	T5812	arg1Of	and,induced
R3867	T5816	T5813	arg2Of	and,by
R3868	T5816	T5814	arg1Of	and,both
R3869	T5816	T5818	arg1Of	and,(
R3870	T5817	T5816	arg2Of	TNFα,and
R3871	T5820	T5818	arg2Of	2C,(
R3872	T5820	T5819	arg1Of	2C,Fig.
R3873	T5821	T5818	arg3Of	),(
R3874	T5823	T5822	arg1Of	expression,No
R3875	T5823	T5824	arg1Of	expression,of
R3876	T5823	T5826	arg1Of	expression,was
R3877	T5823	T5827	arg2Of	expression,seen
R3878	T5825	T5824	arg2Of	Akt3,of
R3879	T5827	T5826	arg2Of	seen,was
R3880	T5827	T5828	arg1Of	seen,in
R3881	T5827	T5836	arg1Of	seen,","
R3882	T5827	T5837	arg1Of	seen,consistently
R3883	T5827	T5838	arg1Of	seen,","
R3884	T5828	T5835	arg1Of	in,and
R3885	T5830	T5828	arg2Of	cells,in
R3886	T5830	T5829	arg1Of	cells,L929
R3887	T5830	T5831	arg1Of	cells,(
R3888	T5833	T5831	arg2Of	S2C,(
R3889	T5833	T5832	arg1Of	S2C,Fig.
R3890	T5834	T5831	arg3Of	),(
R3891	T5840	T5839	arg1Of	siRNA,Akt3
R3892	T5840	T5841	arg1Of	siRNA,had
R3893	T5841	T5838	arg2Of	had,","
R3894	T5841	T5845	arg1Of	had,on
R3895	T5844	T5841	arg2Of	effect,had
R3896	T5844	T5842	arg1Of	effect,no
R3897	T5844	T5843	arg1Of	effect,additional
R3898	T5846	T5845	arg2Of	necroptosis,on
R3899	T5848	T5847	arg1Of	results,Our
R3900	T5848	T5849	arg1Of	results,confirmed
R3901	T5851	T5852	arg1Of	Akt,plays
R3902	T5852	T5849	arg2Of	plays,confirmed
R3903	T5852	T5850	arg1Of	plays,that
R3904	T5852	T5856	arg1Of	plays,in
R3905	T5855	T5852	arg2Of	role,plays
R3906	T5855	T5853	arg1Of	role,a
R3907	T5855	T5854	arg1Of	role,key
R3908	T5857	T5856	arg2Of	necroptosis,in
R3909	T5857	T5858	arg2Of	necroptosis,induced
R3910	T5861	T5858	arg1Of	stimuli,induced
R3911	T5861	T5859	arg2Of	stimuli,by
R3912	T5861	T5860	arg1Of	stimuli,multiple
R3913	T5861	T5862	arg1Of	stimuli,in
R3914	T5864	T5862	arg2Of	cells,in
R3915	T5864	T5863	arg1Of	cells,L929
R3916	T5866	T5865	arg1Of	understand,To
R3917	T5866	T5873	arg1Of	understand,under
R3918	T5868	T5866	arg2Of	activation,understand
R3919	T5868	T5867	arg1Of	activation,the
R3920	T5868	T5869	arg1Of	activation,of
R3921	T5870	T5871	arg1Of	Akt,and
R3922	T5871	T5869	arg2Of	and,of
R3923	T5872	T5871	arg2Of	JNK,and
R3924	T5875	T5873	arg2Of	conditions,under
R3925	T5875	T5874	arg1Of	conditions,necroptotic
R3926	T5877	T5866	arg1Of	we,understand
R3927	T5877	T5878	arg1Of	we,examined
R3928	T5878	T5865	modOf	examined,To
R3929	T5878	T5876	arg1Of	examined,","
R3930	T5878	T5886	arg1Of	examined,at
R3931	T5878	T5889	arg1Of	examined,post
R3932	T5880	T5878	arg2Of	changes,examined
R3933	T5880	T5879	arg1Of	changes,the
R3934	T5880	T5881	arg1Of	changes,in
R3935	T5882	T5883	arg1Of	Akt,and
R3936	T5884	T5883	arg2Of	JNK,and
R3937	T5885	T5881	arg2Of	phosphorylation,in
R3938	T5885	T5882	arg1Of	phosphorylation,Akt
R3939	T5885	T5884	arg1Of	phosphorylation,JNK
R3940	T5888	T5886	arg2Of	hrs,at
R3941	T5888	T5887	arg1Of	hrs,9
R3942	T5890	T5891	arg1Of	zVAD.fmk,and
R3943	T5892	T5891	arg2Of	TNFα,and
R3944	T5893	T5889	arg2Of	stimulation,post
R3945	T5893	T5890	arg1Of	stimulation,zVAD.fmk
R3946	T5893	T5892	arg1Of	stimulation,TNFα
R3947	T5895	T5894	arg1Of	time,This
R3948	T5896	T5897	arg1Of	point,was
R3949	T5896	T5898	arg2Of	point,chosen
R3950	T5898	T5895	arg1Of	chosen,time
R3951	T5898	T5897	arg2Of	chosen,was
R3952	T5898	T5899	arg1Of	chosen,because
R3953	T5900	T5901	arg1Of	it,reflects
R3954	T5901	T5899	arg2Of	reflects,because
R3955	T5904	T5901	arg2Of	stage,reflects
R3956	T5904	T5902	arg1Of	stage,the
R3957	T5904	T5903	arg1Of	stage,early
R3958	T5904	T5905	arg1Of	stage,of
R3959	T5904	T5908	arg1Of	stage,in
R3960	T5907	T5905	arg2Of	death,of
R3961	T5907	T5906	arg1Of	death,cell
R3962	T5910	T5908	arg2Of	system,in
R3963	T5910	T5909	arg1Of	system,our
R3964	T5910	T5911	arg1Of	system,(
R3965	T5913	T5911	arg2Of	S3A,(
R3966	T5913	T5912	arg1Of	S3A,Fig.
R3967	T5913	T5914	arg1Of	S3A,","
R3968	T5915	T5914	arg2Of	B,","
R3969	T5916	T5911	arg3Of	),(
R3970	T5918	T5917	arg2Of	stimulation,Following
R3971	T5918	T5919	arg1Of	stimulation,with
R3972	T5921	T5922	arg1Of	zVAD.fmk,or
R3973	T5922	T5919	arg2Of	or,with
R3974	T5922	T5920	arg1Of	or,either
R3975	T5923	T5922	arg2Of	TNFα,or
R3976	T5924	T5925	arg1Of	we,observed
R3977	T5925	T5917	arg1Of	observed,Following
R3978	T5928	T5925	arg2Of	increase,observed
R3979	T5928	T5926	arg1Of	increase,a
R3980	T5928	T5927	arg1Of	increase,robust
R3981	T5928	T5929	arg1Of	increase,in
R3982	T5928	T5932	arg1Of	increase,at
R3983	T5931	T5929	arg2Of	phosphorylation,in
R3984	T5931	T5930	arg1Of	phosphorylation,Akt
R3985	T5937	T5932	arg2Of	site,at
R3986	T5937	T5933	arg1Of	site,a
R3987	T5937	T5934	arg1Of	site,known
R3988	T5937	T5935	arg1Of	site,major
R3989	T5937	T5936	arg1Of	site,activation
R3990	T5937	T5938	arg1Of	site,","
R3991	T5939	T5938	arg2Of	Thr308,","
R3992	T5939	T5940	arg1Of	Thr308,(
R3993	T5942	T5940	arg2Of	3A,(
R3994	T5942	T5941	arg1Of	3A,Fig.
R3995	T5943	T5940	arg3Of	),(
R3996	T5946	T5947	arg1Of	we,did
R3997	T5946	T5949	arg1Of	we,observe
R3998	T5949	T5944	arg1Of	observe,Interestingly
R3999	T5949	T5945	arg1Of	observe,","
R4000	T5949	T5947	arg2Of	observe,did
R4001	T5949	T5948	arg1Of	observe,not
R4002	T5952	T5949	arg2Of	changes,observe
R4003	T5952	T5950	arg1Of	changes,concomitant
R4004	T5952	T5951	arg1Of	changes,phosphorylation
R4005	T5952	T5953	arg1Of	changes,in
R4006	T5952	T5961	arg1Of	changes,","
R4007	T5958	T5953	arg2Of	site,in
R4008	T5958	T5954	arg1Of	site,the
R4009	T5958	T5955	arg1Of	site,second
R4010	T5958	T5956	arg1Of	site,major
R4011	T5958	T5957	arg1Of	site,activation
R4012	T5958	T5959	arg1Of	site,of
R4013	T5960	T5959	arg2Of	Akt,of
R4014	T5962	T5961	arg2Of	Ser473,","
R4015	T5963	T5965	arg1Of	We,observed
R4016	T5965	T5964	arg1Of	observed,also
R4017	T5967	T5965	arg2Of	increase,observed
R4018	T5967	T5966	arg1Of	increase,an
R4019	T5967	T5968	arg1Of	increase,in
R4020	T5970	T5969	arg1Of	phosphorylation,the
R4021	T5970	T5971	arg1Of	phosphorylation,of
R4022	T5970	T5980	arg1Of	phosphorylation,and
R4023	T5974	T5975	arg1Of	p46,and
R4024	T5976	T5975	arg2Of	p54,and
R4025	T5977	T5971	arg2Of	isoforms,of
R4026	T5977	T5972	arg1Of	isoforms,both
R4027	T5977	T5973	arg1Of	isoforms,the
R4028	T5977	T5974	arg1Of	isoforms,p46
R4029	T5977	T5976	arg1Of	isoforms,p54
R4030	T5977	T5978	arg1Of	isoforms,of
R4031	T5979	T5978	arg2Of	JNK,of
R4032	T5980	T5968	arg2Of	and,in
R4033	T5984	T5980	arg2Of	c-Jun,and
R4034	T5984	T5981	arg1Of	c-Jun,its
R4035	T5984	T5982	arg1Of	c-Jun,major
R4036	T5984	T5983	arg1Of	c-Jun,substrate
R4037	T5984	T5985	arg1Of	c-Jun,(
R4038	T5987	T5985	arg2Of	3A,(
R4039	T5987	T5986	arg1Of	3A,Fig.
R4040	T5988	T5985	arg3Of	),(
R4041	T5990	T5989	arg1Of	data,These
R4042	T5990	T5991	arg1Of	data,indicate
R4043	T5994	T5995	arg1Of	Akt,and
R4044	T5995	T5993	arg1Of	and,both
R4045	T5995	T5997	arg1Of	and,are
R4046	T5995	T5998	arg2Of	and,activated
R4047	T5996	T5995	arg2Of	JNK,and
R4048	T5998	T5991	arg2Of	activated,indicate
R4049	T5998	T5992	arg1Of	activated,that
R4050	T5998	T5997	arg2Of	activated,are
R4051	T5998	T5999	arg1Of	activated,under
R4052	T6001	T5999	arg2Of	conditions,under
R4053	T6001	T6000	arg1Of	conditions,necroptotic
R4054	T6005	T6002	arg1Of	inhibitor,The
R4055	T6005	T6003	arg1Of	inhibitor,RIP1
R4056	T6005	T6004	arg1Of	inhibitor,kinase
R4057	T6005	T6006	arg1Of	inhibitor,","
R4058	T6005	T6010	arg1Of	inhibitor,prevented
R4059	T6007	T6006	arg2Of	Nec-1,","
R4060	T6010	T6008	arg1Of	prevented,","
R4061	T6010	T6009	arg1Of	prevented,completely
R4062	T6010	T6017	arg1Of	prevented,","
R4063	T6010	T6018	arg1Of	prevented,while
R4064	T6012	T6010	arg2Of	increase,prevented
R4065	T6012	T6011	arg1Of	increase,the
R4066	T6012	T6013	arg1Of	increase,in
R4067	T6016	T6013	arg2Of	phosphorylation,in
R4068	T6016	T6014	arg1Of	phosphorylation,Thr308
R4069	T6016	T6015	arg1Of	phosphorylation,Akt
R4070	T6019	T6020	arg1Of	Nec-1i,did
R4071	T6020	T6018	arg2Of	did,while
R4072	T6020	T6021	arg1Of	did,not
R4073	T6020	T6022	arg1Of	did,(
R4074	T6024	T6022	arg2Of	3A,(
R4075	T6024	T6023	arg1Of	3A,Fig.
R4076	T6024	T6025	arg1Of	3A,","
R4077	T6027	T6025	arg2Of	S1D,","
R4078	T6027	T6026	arg1Of	S1D,Fig.
R4079	T6028	T6022	arg3Of	),(
R4080	T6031	T6032	arg1Of	Nec-1,prevented
R4081	T6031	T6044	arg1Of	Nec-1,reduced
R4082	T6032	T6038	arg1Of	prevented,in
R4083	T6032	T6042	arg1Of	prevented,and
R4084	T6034	T6032	arg2Of	induction,prevented
R4085	T6034	T6033	arg1Of	induction,the
R4086	T6034	T6035	arg1Of	induction,of
R4087	T6037	T6035	arg2Of	phosphorylation,of
R4088	T6037	T6036	arg1Of	phosphorylation,JNK
R4089	T6038	T6040	arg1Of	in,to
R4090	T6039	T6038	arg2Of	response,in
R4091	T6041	T6038	arg3Of	zVAD.fmk,in
R4092	T6042	T6029	arg1Of	and,Similarly
R4093	T6042	T6030	arg1Of	and,","
R4094	T6044	T6042	arg2Of	reduced,and
R4095	T6044	T6043	arg1Of	reduced,substantially
R4096	T6044	T6047	arg1Of	reduced,after
R4097	T6046	T6044	arg2Of	change,reduced
R4098	T6046	T6045	arg1Of	change,this
R4099	T6049	T6047	arg2Of	addition,after
R4100	T6049	T6048	arg1Of	addition,TNFα
R4101	T6050	T6051	arg1Of	We,observed
R4102	T6053	T6051	arg2Of	changes,observed
R4103	T6053	T6052	arg1Of	changes,some
R4104	T6053	T6054	arg1Of	changes,in
R4105	T6057	T6054	arg2Of	levels,in
R4106	T6057	T6055	arg1Of	levels,total
R4107	T6057	T6056	arg1Of	levels,protein
R4108	T6057	T6058	arg1Of	levels,of
R4109	T6059	T6060	arg1Of	JNK,and
R4110	T6060	T6058	arg2Of	and,of
R4111	T6060	T6062	arg1Of	and,following
R4112	T6061	T6060	arg2Of	c-Jun,and
R4113	T6064	T6062	arg2Of	stimulation,following
R4114	T6064	T6063	arg1Of	stimulation,necroptotic
R4115	T6065	T6066	arg1Of	Some,of
R4116	T6065	T6069	arg1Of	Some,","
R4117	T6065	T6076	arg1Of	Some,were
R4118	T6065	T6078	arg2Of	Some,attenuated
R4119	T6068	T6066	arg2Of	changes,of
R4120	T6068	T6067	arg1Of	changes,these
R4121	T6072	T6069	arg2Of	increase,","
R4122	T6072	T6070	arg1Of	increase,e.g.
R4123	T6072	T6071	arg1Of	increase,zVAD.fmk-induced
R4124	T6072	T6073	arg1Of	increase,in
R4125	T6074	T6073	arg2Of	c-Jun,in
R4126	T6078	T6075	arg1Of	attenuated,","
R4127	T6078	T6076	arg2Of	attenuated,were
R4128	T6078	T6077	arg1Of	attenuated,also
R4129	T6080	T6078	arg1Of	Nec-1,attenuated
R4130	T6080	T6079	arg2Of	Nec-1,by
R4131	T6083	T6084	arg1Of	Nec-1,did
R4132	T6083	T6086	arg1Of	Nec-1,alter
R4133	T6086	T6081	arg1Of	alter,Importantly
R4134	T6086	T6082	arg1Of	alter,","
R4135	T6086	T6084	arg2Of	alter,did
R4136	T6086	T6085	arg1Of	alter,not
R4137	T6090	T6086	arg2Of	levels,alter
R4138	T6090	T6087	arg1Of	levels,the
R4139	T6090	T6088	arg1Of	levels,basal
R4140	T6090	T6089	arg1Of	levels,phosphorylation
R4141	T6090	T6091	arg1Of	levels,of
R4142	T6093	T6094	arg1Of	Akt,or
R4143	T6094	T6091	arg2Of	or,of
R4144	T6094	T6092	arg1Of	or,either
R4145	T6094	T6096	arg1Of	or,(
R4146	T6095	T6094	arg2Of	JNK,or
R4147	T6098	T6096	arg2Of	3A,(
R4148	T6098	T6097	arg1Of	3A,Fig.
R4149	T6099	T6096	arg3Of	),(
R4150	T6100	T6101	arg1Of	This,established
R4151	T6104	T6103	arg1Of	Thr308,Akt
R4152	T6104	T6105	arg1Of	Thr308,and
R4153	T6105	T6108	arg1Of	and,during
R4154	T6105	T6110	arg1Of	and,is
R4155	T6105	T6112	arg1Of	and,dependent
R4156	T6107	T6105	arg2Of	phosphorylation,and
R4157	T6107	T6106	arg1Of	phosphorylation,JNK
R4158	T6109	T6108	arg2Of	necroptosis,during
R4159	T6110	T6101	arg2Of	is,established
R4160	T6110	T6102	arg1Of	is,that
R4161	T6112	T6110	arg2Of	dependent,is
R4162	T6112	T6111	arg1Of	dependent,RIP1
R4163	T6115	T6116	arg1Of	we,discovered
R4164	T6116	T6113	arg1Of	discovered,Interestingly
R4165	T6116	T6114	arg1Of	discovered,","
R4166	T6119	T6118	arg1Of	phosphorylation,the
R4167	T6119	T6120	arg1Of	phosphorylation,of
R4168	T6119	T6127	arg1Of	phosphorylation,are
R4169	T6122	T6121	arg1Of	Thr308,Akt
R4170	T6122	T6123	arg1Of	Thr308,","
R4171	T6123	T6125	arg1Of	",",and
R4172	T6124	T6123	arg2Of	JNK,","
R4173	T6125	T6120	arg2Of	and,of
R4174	T6126	T6125	arg2Of	Jun,and
R4175	T6127	T6116	arg2Of	are,discovered
R4176	T6127	T6117	arg1Of	are,that
R4177	T6129	T6127	arg2Of	events,are
R4178	T6129	T6128	arg1Of	events,late
R4179	T6129	T6130	arg1Of	events,following
R4180	T6129	T6137	arg1Of	events,that
R4181	T6129	T6138	arg1Of	events,coincide
R4182	T6132	T6130	arg2Of	stimulation,following
R4183	T6132	T6131	arg1Of	stimulation,zVAD.fmk
R4184	T6132	T6133	arg1Of	stimulation,(
R4185	T6135	T6133	arg2Of	3B,(
R4186	T6135	T6134	arg1Of	3B,Fig.
R4187	T6136	T6133	arg3Of	),(
R4188	T6138	T6139	arg1Of	coincide,with
R4189	T6141	T6139	arg2Of	onset,with
R4190	T6141	T6140	arg1Of	onset,the
R4191	T6141	T6142	arg1Of	onset,of
R4192	T6141	T6144	arg1Of	onset,at
R4193	T6143	T6142	arg2Of	necroptosis,of
R4194	T6147	T6144	arg2Of	post-stimulation,at
R4195	T6147	T6145	arg1Of	post-stimulation,6
R4196	T6147	T6146	arg1Of	post-stimulation,hr
R4197	T6147	T6148	arg1Of	post-stimulation,(
R4198	T6150	T6148	arg2Of	S3A,(
R4199	T6150	T6149	arg1Of	S3A,Fig.
R4200	T6151	T6148	arg3Of	),(
R4201	T6154	T6152	arg1Of	understand,To
R4202	T6154	T6153	arg1Of	understand,better
R4203	T6154	T6163	arg1Of	understand,to
R4204	T6156	T6154	arg2Of	contributions,understand
R4205	T6156	T6155	arg1Of	contributions,the
R4206	T6156	T6157	arg1Of	contributions,of
R4207	T6159	T6158	arg1Of	factors,growth
R4208	T6159	T6160	arg1Of	factors,and
R4209	T6160	T6157	arg2Of	and,of
R4210	T6162	T6160	arg2Of	kinase,and
R4211	T6162	T6161	arg1Of	kinase,RIP1
R4212	T6165	T6163	arg2Of	regulation,to
R4213	T6165	T6164	arg1Of	regulation,necroptotic
R4214	T6165	T6166	arg1Of	regulation,of
R4215	T6167	T6166	arg2Of	Akt,of
R4216	T6169	T6154	arg1Of	we,understand
R4217	T6169	T6171	arg1Of	we,analyzed
R4218	T6171	T6152	modOf	analyzed,To
R4219	T6171	T6168	arg1Of	analyzed,","
R4220	T6171	T6170	arg1Of	analyzed,next
R4221	T6174	T6171	arg2Of	course,analyzed
R4222	T6174	T6172	arg1Of	course,the
R4223	T6174	T6173	arg1Of	course,time
R4224	T6174	T6175	arg1Of	course,of
R4225	T6178	T6175	arg2Of	changes,of
R4226	T6178	T6176	arg1Of	changes,these
R4227	T6178	T6177	arg1Of	changes,phosphorylation
R4228	T6178	T6179	arg1Of	changes,under
R4229	T6182	T6179	arg2Of	conditions,under
R4230	T6182	T6180	arg1Of	conditions,serum
R4231	T6182	T6181	arg1Of	conditions,free
R4232	T6183	T6184	arg1Of	We,found
R4233	T6187	T6186	arg1Of	addition,the
R4234	T6187	T6188	arg1Of	addition,of
R4235	T6187	T6196	arg1Of	addition,led
R4236	T6189	T6188	arg2Of	bFGF,of
R4237	T6189	T6190	arg1Of	bFGF,alone
R4238	T6189	T6192	arg1Of	bFGF,in
R4239	T6190	T6191	arg1Of	alone,or
R4240	T6192	T6191	arg2Of	in,or
R4241	T6193	T6192	arg2Of	combination,in
R4242	T6193	T6194	arg1Of	combination,with
R4243	T6195	T6194	arg2Of	zVAD.fmk,with
R4244	T6196	T6184	arg2Of	led,found
R4245	T6196	T6185	arg1Of	led,that
R4246	T6196	T6197	arg1Of	led,to
R4247	T6196	T6221	arg1Of	led,","
R4248	T6196	T6222	modOf	led,reflecting
R4249	T6200	T6201	arg1Of	rapid,and
R4250	T6202	T6201	arg2Of	transient,and
R4251	T6203	T6197	arg2Of	increase,to
R4252	T6203	T6198	arg1Of	increase,a
R4253	T6203	T6199	arg1Of	increase,substantial
R4254	T6203	T6200	arg1Of	increase,rapid
R4255	T6203	T6202	arg1Of	increase,transient
R4256	T6203	T6204	arg1Of	increase,in
R4257	T6206	T6207	arg1Of	Thr308,and
R4258	T6207	T6205	arg1Of	and,both
R4259	T6208	T6207	arg2Of	Ser473,and
R4260	T6209	T6206	arg1Of	phosphorylation,Thr308
R4261	T6209	T6208	arg1Of	phosphorylation,Ser473
R4262	T6209	T6210	arg1Of	phosphorylation,of
R4263	T6209	T6214	arg1Of	phosphorylation,as
R4264	T6211	T6210	arg2Of	Akt,of
R4265	T6214	T6204	arg2Of	as,in
R4266	T6214	T6212	arg1Of	as,as
R4267	T6214	T6213	arg1Of	as,well
R4268	T6215	T6216	arg1Of	JNK,and
R4269	T6216	T6214	arg2Of	and,as
R4270	T6216	T6218	arg1Of	and,at
R4271	T6217	T6216	arg2Of	c-Jun,and
R4272	T6220	T6218	arg2Of	minutes,at
R4273	T6220	T6219	arg1Of	minutes,15
R4274	T6225	T6222	arg2Of	response,reflecting
R4275	T6225	T6223	arg1Of	response,the
R4276	T6225	T6224	arg1Of	response,expected
R4277	T6225	T6226	arg1Of	response,to
R4278	T6229	T6226	arg2Of	stimulation,to
R4279	T6229	T6227	arg1Of	stimulation,growth
R4280	T6229	T6228	arg1Of	stimulation,factor
R4281	T6229	T6230	arg1Of	stimulation,(
R4282	T6232	T6230	arg2Of	3C,(
R4283	T6232	T6231	arg1Of	3C,Fig.
R4284	T6233	T6230	arg3Of	),(
R4285	T6236	T6237	arg1Of	IGF/zVAD,","
R4286	T6236	T6238	arg1Of	IGF/zVAD,which
R4287	T6236	T6240	arg1Of	IGF/zVAD,promoted
R4288	T6236	T6248	arg1Of	IGF/zVAD,produced
R4289	T6240	T6239	arg1Of	promoted,also
R4290	T6240	T6243	arg1Of	promoted,under
R4291	T6242	T6240	arg2Of	death,promoted
R4292	T6242	T6241	arg1Of	death,cell
R4293	T6246	T6243	arg2Of	conditions,under
R4294	T6246	T6244	arg1Of	conditions,serum
R4295	T6246	T6245	arg1Of	conditions,free
R4296	T6248	T6234	arg1Of	produced,Similarly
R4297	T6248	T6235	arg1Of	produced,","
R4298	T6248	T6247	arg1Of	produced,","
R4299	T6248	T6255	arg1Of	produced,on
R4300	T6248	T6257	arg1Of	produced,","
R4301	T6248	T6258	arg1Of	produced,while
R4302	T6251	T6248	arg2Of	increase,produced
R4303	T6251	T6249	arg1Of	increase,a
R4304	T6251	T6250	arg2Of	increase,delayed
R4305	T6251	T6252	arg1Of	increase,in
R4306	T6254	T6252	arg2Of	phosphorylation,in
R4307	T6254	T6253	arg1Of	phosphorylation,Thr308
R4308	T6256	T6255	arg2Of	Akt,on
R4309	T6259	T6260	arg1Of	IGF,alone
R4310	T6259	T6261	arg1Of	IGF,caused
R4311	T6261	T6258	arg2Of	caused,while
R4312	T6261	T6262	arg1Of	caused,solely
R4313	T6264	T6265	arg1Of	early,","
R4314	T6266	T6265	arg2Of	transient,","
R4315	T6267	T6261	arg2Of	increase,caused
R4316	T6267	T6263	arg1Of	increase,an
R4317	T6267	T6264	arg1Of	increase,early
R4318	T6267	T6266	arg1Of	increase,transient
R4319	T6267	T6268	arg1Of	increase,in
R4320	T6269	T6268	arg2Of	phosphorylation,in
R4321	T6269	T6270	arg1Of	phosphorylation,(
R4322	T6272	T6270	arg2Of	S3C,(
R4323	T6272	T6271	arg1Of	S3C,Fig.
R4324	T6273	T6270	arg3Of	),(
R4325	T6274	T6275	arg1Of	We,confirmed
R4326	T6274	T6286	arg1Of	We,using
R4327	T6275	T6286	modOf	confirmed,using
R4328	T6277	T6275	arg2Of	kinetics,confirmed
R4329	T6277	T6276	arg1Of	kinetics,the
R4330	T6277	T6278	arg1Of	kinetics,of
R4331	T6281	T6282	arg1Of	Thr308,and
R4332	T6283	T6282	arg2Of	Ser473,and
R4333	T6285	T6278	arg2Of	changes,of
R4334	T6285	T6279	arg1Of	changes,the
R4335	T6285	T6280	arg1Of	changes,Akt
R4336	T6285	T6281	arg1Of	changes,Thr308
R4337	T6285	T6283	arg1Of	changes,Ser473
R4338	T6285	T6284	arg1Of	changes,phosphorylation
R4339	T6290	T6286	arg2Of	assay,using
R4340	T6290	T6287	arg1Of	assay,a
R4341	T6290	T6288	arg1Of	assay,quantitative
R4342	T6290	T6289	arg1Of	assay,ELISA
R4343	T6290	T6291	arg1Of	assay,","
R4344	T6290	T6292	arg1Of	assay,which
R4345	T6290	T6294	arg1Of	assay,showed
R4346	T6294	T6293	arg1Of	showed,also
R4347	T6294	T6305	arg1Of	showed,(
R4348	T6300	T6294	arg2Of	increase,showed
R4349	T6300	T6295	arg1Of	increase,a
R4350	T6300	T6296	arg1Of	increase,robust
R4351	T6300	T6297	arg2Of	increase,delayed
R4352	T6300	T6298	arg1Of	increase,necroptosis-specific
R4353	T6300	T6299	arg1Of	increase,RIP1-dependent
R4354	T6300	T6301	arg1Of	increase,in
R4355	T6304	T6301	arg2Of	phosphorylation,in
R4356	T6304	T6302	arg1Of	phosphorylation,Akt
R4357	T6304	T6303	arg1Of	phosphorylation,Thr308
R4358	T6307	T6305	arg2Of	S3D,(
R4359	T6307	T6306	arg1Of	S3D,Fig.
R4360	T6307	T6308	arg1Of	S3D,","
R4361	T6309	T6308	arg2Of	E,","
R4362	T6310	T6305	arg3Of	),(
R4363	T6311	T6312	arg1Of	Taken,together
R4364	T6315	T6314	arg1Of	results,these
R4365	T6315	T6316	arg1Of	results,indicate
R4366	T6316	T6311	modOf	indicate,Taken
R4367	T6316	T6313	arg1Of	indicate,","
R4368	T6321	T6318	arg1Of	increases,the
R4369	T6321	T6319	arg2Of	increases,observed
R4370	T6321	T6320	arg2Of	increases,delayed
R4371	T6321	T6322	arg1Of	increases,in
R4372	T6321	T6327	arg1Of	increases,","
R4373	T6321	T6335	arg1Of	increases,represent
R4374	T6323	T6324	arg1Of	Akt,and
R4375	T6325	T6324	arg2Of	JNK,and
R4376	T6326	T6322	arg2Of	phosphorylation,in
R4377	T6326	T6323	arg1Of	phosphorylation,Akt
R4378	T6326	T6325	arg1Of	phosphorylation,JNK
R4379	T6328	T6327	arg2Of	preceding,","
R4380	T6330	T6328	arg2Of	onset,preceding
R4381	T6330	T6329	arg1Of	onset,the
R4382	T6330	T6331	arg1Of	onset,of
R4383	T6333	T6331	arg2Of	death,of
R4384	T6333	T6332	arg1Of	death,cell
R4385	T6335	T6316	arg2Of	represent,indicate
R4386	T6335	T6317	arg1Of	represent,that
R4387	T6335	T6334	arg1Of	represent,","
R4388	T6335	T6342	arg1Of	represent,from
R4389	T6337	T6335	arg2Of	consequences,represent
R4390	T6337	T6336	arg1Of	consequences,specific
R4391	T6337	T6338	arg1Of	consequences,of
R4392	T6337	T6341	arg1Of	consequences,downstream
R4393	T6340	T6338	arg2Of	signaling,of
R4394	T6340	T6339	arg1Of	signaling,necroptotic
R4395	T6344	T6342	arg2Of	kinase,from
R4396	T6344	T6343	arg1Of	kinase,RIP1
R20067	T28985	T28986	arg1Of	Akt,contributes
R20068	T28986	T28987	arg1Of	contributes,to
R20069	T28988	T28987	arg2Of	necroptosis,to
R20070	T28988	T28989	arg2Of	necroptosis,induced
R20071	T28991	T28992	arg1Of	zVAD.fmk,and
R20072	T28992	T28989	arg1Of	and,induced
R20073	T28992	T28990	arg2Of	and,by
R20074	T28993	T28992	arg2Of	TNFα,and
R20075	T28995	T28994	arg2Of	A,(
R20076	T28995	T28996	arg1Of	A,","
R20077	T28997	T28996	arg2Of	B,","
R20078	T28998	T28994	arg3Of	),(
R20079	T28999	T28994	arg1Of	Necroptosis,(
R20080	T28999	T29000	arg1Of	Necroptosis,was
R20081	T28999	T29001	arg2Of	Necroptosis,induced
R20082	T29001	T29000	arg2Of	induced,was
R20083	T29001	T29021	arg1Of	induced,in
R20084	T29003	T29004	arg1Of	zVAD.fmk,or
R20085	T29004	T29006	arg1Of	or,(
R20086	T29004	T29012	arg1Of	or,or
R20087	T29005	T29004	arg2Of	TNFα,or
R20088	T29008	T29006	arg2Of	serum,(
R20089	T29008	T29007	arg1Of	serum,full
R20090	T29008	T29009	arg1Of	serum,","
R20091	T29010	T29009	arg2Of	A,","
R20092	T29011	T29006	arg3Of	),(
R20093	T29012	T29001	arg1Of	or,induced
R20094	T29012	T29002	arg2Of	or,by
R20095	T29014	T29012	arg2Of	factors/zVAD.fmk,or
R20096	T29014	T29013	arg1Of	factors/zVAD.fmk,growth
R20097	T29014	T29015	arg1Of	factors/zVAD.fmk,(
R20098	T29016	T29015	arg2Of	serum,(
R20099	T29016	T29017	arg1Of	serum,free
R20100	T29016	T29018	arg1Of	serum,","
R20101	T29019	T29018	arg2Of	B,","
R20102	T29020	T29015	arg3Of	),(
R20103	T29023	T29021	arg2Of	presence,in
R20104	T29023	T29022	arg1Of	presence,the
R20105	T29023	T29024	arg1Of	presence,of
R20106	T29025	T29024	arg2Of	inhibitors,of
R20107	T29025	T29026	arg1Of	inhibitors,of
R20108	T29027	T29028	arg1Of	Akt,(
R20109	T29027	T29033	arg1Of	Akt,","
R20110	T29030	T29028	arg2Of	inhibitor,(
R20111	T29030	T29029	arg1Of	inhibitor,Akt
R20112	T29030	T29031	arg1Of	inhibitor,VIII
R20113	T29032	T29028	arg3Of	),(
R20114	T29033	T29038	arg1Of	",",","
R20115	T29034	T29033	arg2Of	JNK,","
R20116	T29034	T29035	arg1Of	JNK,(
R20117	T29036	T29035	arg2Of	SP600125,(
R20118	T29037	T29035	arg3Of	),(
R20119	T29038	T29044	arg1Of	",",and
R20120	T29039	T29038	arg2Of	p38,","
R20121	T29039	T29040	arg1Of	p38,(
R20122	T29041	T29040	arg2Of	PD169316,(
R20123	T29042	T29040	arg3Of	),(
R20124	T29044	T29026	arg2Of	and,of
R20125	T29044	T29043	arg1Of	and,","
R20126	T29045	T29044	arg2Of	Erk,and
R20127	T29045	T29046	arg1Of	Erk,(
R20128	T29047	T29046	arg2Of	UO126,(
R20129	T29048	T29046	arg3Of	),(
R20130	T29050	T29049	arg1Of	viability,Cell
R20131	T29050	T29051	arg1Of	viability,was
R20132	T29050	T29052	arg2Of	viability,determined
R20133	T29052	T29051	arg2Of	determined,was
R20134	T29052	T29053	arg1Of	determined,after
R20135	T29055	T29053	arg2Of	hrs.,after
R20136	T29055	T29054	arg1Of	hrs.,24
R20137	T29055	T29056	arg1Of	hrs.,(
R20138	T29057	T29056	arg2Of	C,(
R20139	T29058	T29056	arg3Of	),(
R20140	T29060	T29059	arg1Of	cells,L929
R20141	T29060	T29061	arg2Of	cells,transfected
R20142	T29060	T29073	arg1Of	cells,were
R20143	T29060	T29074	arg2Of	cells,treated
R20144	T29061	T29062	arg1Of	transfected,with
R20145	T29063	T29064	arg1Of	Akt1,","
R20146	T29064	T29067	arg1Of	",",and
R20147	T29065	T29064	arg2Of	Akt2,","
R20148	T29067	T29062	arg2Of	and,with
R20149	T29067	T29066	arg1Of	and,","
R20150	T29067	T29070	arg1Of	and,for
R20151	T29069	T29067	arg2Of	siRNAs,and
R20152	T29069	T29068	arg1Of	siRNAs,Akt3
R20153	T29072	T29070	arg2Of	hrs,for
R20154	T29072	T29071	arg1Of	hrs,72
R20155	T29074	T29051	modOf	treated,was
R20156	T29074	T29073	arg2Of	treated,were
R20157	T29074	T29075	arg1Of	treated,with
R20158	T29076	T29077	arg1Of	zVAD.fmk,or
R20159	T29077	T29075	arg2Of	or,with
R20160	T29077	T29079	arg1Of	or,for
R20161	T29078	T29077	arg2Of	TNFα,or
R20162	T29081	T29079	arg2Of	hrs,for
R20163	T29081	T29080	arg1Of	hrs,9
R20164	T29083	T29082	arg1Of	viability,Cell
R20165	T29083	T29084	arg1Of	viability,and
R20166	T29084	T29088	arg1Of	and,were
R20167	T29084	T29089	arg2Of	and,determined
R20168	T29087	T29084	arg2Of	levels,and
R20169	T29087	T29085	arg1Of	levels,Akt
R20170	T29087	T29086	arg1Of	levels,expression
R20171	T29089	T29088	arg2Of	determined,were
R20172	T29089	T29090	arg1Of	determined,after
R20173	T29092	T29090	arg2Of	hrs,after
R20174	T29092	T29091	arg1Of	hrs,24
R20175	T29095	T29093	arg2Of	graphs,In
R20176	T29095	T29094	arg1Of	graphs,all
R20177	T29097	T29098	arg1Of	average±SD,was
R20178	T29097	T29099	arg2Of	average±SD,plotted
R20179	T29099	T29093	arg1Of	plotted,In
R20180	T29099	T29096	arg1Of	plotted,","
R20181	T29099	T29098	arg2Of	plotted,was
R20455	T29534	T29532	arg1Of	phosphorylation,RIP1
R20456	T29534	T29533	arg1Of	phosphorylation,kinase-dependent
R20457	T29534	T29535	arg1Of	phosphorylation,of
R20458	T29534	T29539	arg1Of	phosphorylation,during
R20459	T29536	T29537	arg1Of	Akt,and
R20460	T29537	T29535	arg2Of	and,of
R20461	T29538	T29537	arg2Of	JNK,and
R20462	T29540	T29539	arg2Of	necroptosis,during
R20463	T29542	T29541	arg2Of	A,(
R20464	T29543	T29541	arg3Of	),(
R20465	T29545	T29541	arg1Of	cells,(
R20466	T29545	T29544	arg1Of	cells,L929
R20467	T29545	T29546	arg1Of	cells,were
R20468	T29545	T29547	arg2Of	cells,treated
R20469	T29547	T29546	arg2Of	treated,were
R20470	T29547	T29548	arg1Of	treated,with
R20471	T29547	T29552	arg1Of	treated,for
R20472	T29547	T29555	arg1Of	treated,","
R20473	T29547	T29556	modOf	treated,followed
R20474	T29549	T29550	arg1Of	zVAD.fmk,or
R20475	T29550	T29548	arg2Of	or,with
R20476	T29551	T29550	arg2Of	TNFα,or
R20477	T29554	T29552	arg2Of	hr,for
R20478	T29554	T29553	arg1Of	hr,9
R20479	T29559	T29556	arg1Of	blotting,followed
R20480	T29559	T29557	arg2Of	blotting,by
R20481	T29559	T29558	arg1Of	blotting,western
R20482	T29559	T29560	arg1Of	blotting,with
R20483	T29562	T29560	arg2Of	antibodies.,with
R20484	T29562	T29561	arg2Of	antibodies.,indicated
R20485	T29564	T29563	arg2Of	B,(
R20486	T29564	T29565	arg1Of	B,","
R20487	T29564	T29566	arg1Of	B,C
R20488	T29567	T29563	arg3Of	),(
R20489	T29569	T29568	arg1Of	cells,L929
R20490	T29569	T29570	arg1Of	cells,were
R20491	T29569	T29571	arg2Of	cells,treated
R20492	T29571	T29570	arg2Of	treated,were
R20493	T29571	T29572	arg1Of	treated,with
R20494	T29573	T29574	arg1Of	zVAD.fmk,(
R20495	T29573	T29577	arg1Of	zVAD.fmk,or
R20496	T29575	T29574	arg2Of	B,(
R20497	T29576	T29574	arg3Of	),(
R20498	T29577	T29572	arg2Of	or,with
R20499	T29578	T29577	arg2Of	bFGF/zVAD.fmk,or
R20500	T29578	T29579	arg1Of	bFGF/zVAD.fmk,(
R20501	T29582	T29579	arg2Of	conditions,(
R20502	T29582	T29580	arg1Of	conditions,serum
R20503	T29582	T29581	arg1Of	conditions,free
R20504	T29582	T29583	arg1Of	conditions,","
R20505	T29584	T29583	arg2Of	C,","
R20506	T29585	T29579	arg3Of	),(
R20507	T29587	T29588	arg1Of	samples,were
R20508	T29587	T29589	arg2Of	samples,collected
R20509	T29589	T29588	arg2Of	collected,were
R20510	T29589	T29590	arg1Of	collected,at
R20511	T29594	T29590	arg2Of	points,at
R20512	T29594	T29591	arg1Of	points,the
R20513	T29594	T29592	arg2Of	points,indicated
R20514	T29594	T29593	arg1Of	points,time
R20515	T29594	T29595	arg1Of	points,for
R20516	T29597	T29595	arg2Of	blot.,for
R20517	T29597	T29596	arg1Of	blot.,western
R20518	T29597	T29598	arg1Of	blot.,(
R20519	T29599	T29598	arg2Of	D,(
R20520	T29600	T29598	arg3Of	),(
R20521	T29601	T29602	arg1Of	Nec-1,was
R20522	T29601	T29603	arg2Of	Nec-1,added
R20523	T29603	T29602	arg2Of	added,was
R20524	T29603	T29604	arg1Of	added,to
R20525	T29606	T29604	arg2Of	cells,to
R20526	T29606	T29605	arg1Of	cells,the
R20527	T29606	T29607	arg2Of	cells,stimulated
R20528	T29607	T29608	arg1Of	stimulated,with
R20529	T29607	T29617	arg1Of	stimulated,for
R20530	T29607	T29623	modOf	stimulated,followed
R20531	T29609	T29610	arg1Of	bFGF,or
R20532	T29610	T29608	arg2Of	or,with
R20533	T29610	T29612	arg1Of	or,(
R20534	T29611	T29610	arg2Of	bFGF/zVAD,or
R20535	T29615	T29612	arg2Of	conditions,(
R20536	T29615	T29613	arg1Of	conditions,serum
R20537	T29615	T29614	arg1Of	conditions,free
R20538	T29616	T29612	arg3Of	),(
R20539	T29619	T29618	arg1Of	min,15
R20540	T29619	T29620	arg1Of	min,or
R20541	T29620	T29617	arg2Of	or,for
R20542	T29622	T29620	arg2Of	hr,or
R20543	T29622	T29621	arg1Of	hr,9
R20544	T29626	T29623	arg1Of	blot,followed
R20545	T29626	T29624	arg2Of	blot,by
R20546	T29626	T29625	arg1Of	blot,western
R20547	T29626	T29627	arg1Of	blot,with
R20548	T29630	T29627	arg2Of	antibodies,with
R20549	T29630	T29628	arg1Of	antibodies,the
R20550	T29630	T29629	arg1Of	antibodies,indicated

bionlp-st-ge-2016-test-proteins

Id	Subject	Object	Predicate	Lexical cue
T29413	3527-3531	Protein	denotes	bFGF
T29412	3519-3523	Protein	denotes	bFGF
T29411	3355-3359	Protein	denotes	bFGF
T29410	3233-3237	Protein	denotes	TNFα
T29409	3115-3119	Protein	denotes	RIP1
T5400	6344-6348	Protein	denotes	RIP1
T5399	6060-6064	Protein	denotes	RIP1
T5398	5636-5640	Protein	denotes	RIP1
T5397	5492-5496	Protein	denotes	bFGF
T5396	5397-5401	Protein	denotes	bFGF
T5395	5388-5392	Protein	denotes	bFGF
T5394	5348-5353	Protein	denotes	c-Jun
T5393	5076-5080	Protein	denotes	bFGF
T5392	5053-5057	Protein	denotes	bFGF
T5391	4925-4930	Protein	denotes	c-Jun
T5390	4764-4768	Protein	denotes	bFGF
T5389	4593-4597	Protein	denotes	RIP1
T5388	4297-4301	Protein	denotes	RIP1
T5387	4082-4087	Protein	denotes	c-Jun
T5386	3984-3989	Protein	denotes	c-Jun
T5385	3909-3913	Protein	denotes	TNFα
T5384	3714-3717	Protein	denotes	Akt
T5383	3640-3644	Protein	denotes	RIP1
T5382	2968-2973	Protein	denotes	c-Jun
T5381	2924-2927	Protein	denotes	p54
T5380	2916-2919	Protein	denotes	p46
T5379	2620-2624	Protein	denotes	TNFα
T5378	2450-2454	Protein	denotes	TNFα
T5377	2136-2146	Protein	denotes	Akt3 siRNA
T5376	2078-2082	Protein	denotes	Akt3
T5375	2045-2049	Protein	denotes	TNFα
T5374	1965-1969	Protein	denotes	Akt2
T5373	1956-1960	Protein	denotes	Akt1
T5372	983-987	Protein	denotes	TNFα
T5371	765-769	Protein	denotes	TNFα
T5370	645-649	Protein	denotes	TNFα
T5369	498-503	Protein	denotes	IGF-1
T5368	490-494	Protein	denotes	bFGF
T28961	1480-1484	Protein	denotes	TNFα
T28960	1427-1438	Protein	denotes	Akt3 siRNAs
T28959	1417-1421	Protein	denotes	Akt2
T28958	1411-1415	Protein	denotes	Akt1
T28957	1163-1167	Protein	denotes	TNFα
T28956	1112-1116	Protein	denotes	TNFα

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T29656	3527-3531	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T29655	3519-3523	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T29654	3355-3359	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T29653	3233-3237	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T29652	3156-3159	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T29651	3156-3159	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T29650	3156-3159	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T29649	3115-3119	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T29121	1480-1484	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T29120	1163-1167	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T29119	1112-1116	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T29118	1515-1518	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T29117	1265-1268	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T29116	1260-1263	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T29115	1057-1060	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T29114	1515-1518	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T29113	1265-1268	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T29112	1260-1263	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T29111	1057-1060	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T29108	1260-1263	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T29107	1057-1060	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6532	2620-2624	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T6510	4370-4373	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6509	4240-4243	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6508	4196-4199	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6507	3714-3717	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6506	3015-3018	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6505	2839-2842	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6504	2658-2661	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6503	2395-2398	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6502	2326-2329	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6501	2215-2218	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6500	1943-1946	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6499	1863-1866	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6498	1720-1723	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6497	1667-1670	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6496	566-569	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6495	340-343	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6494	335-338	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6493	229-232	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6492	36-39	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6491	6207-6210	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6490	6087-6090	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6489	5924-5927	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6488	5796-5799	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6487	5579-5582	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6486	5336-5339	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6485	5188-5191	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6484	4902-4905	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6483	4634-4637	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6482	4370-4373	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6481	4240-4243	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6480	4196-4199	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6479	3714-3717	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6478	3015-3018	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6477	2839-2842	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6476	2658-2661	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6475	2395-2398	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6474	2326-2329	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6473	2215-2218	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6472	1943-1946	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6471	1863-1866	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6470	1720-1723	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6469	1667-1670	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6468	566-569	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6467	340-343	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6466	335-338	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6465	229-232	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6446	2326-2329	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6445	2215-2218	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6444	1943-1946	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6443	1863-1866	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6442	1720-1723	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6441	1667-1670	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6440	566-569	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6439	340-343	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6438	335-338	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6437	229-232	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6436	36-39	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6435	6344-6348	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T6434	6060-6064	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T6433	5636-5640	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T6432	4593-4597	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T6431	4297-4301	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T6430	3640-3644	http://www.uniprot.org/uniprot/Q13546	denotes	RIP1
T6526	5492-5496	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T6525	5397-5401	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T6524	5388-5392	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T6523	5076-5080	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T6522	5053-5057	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T6521	4764-4768	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T6520	490-494	http://www.uniprot.org/uniprot/Q788Q8	denotes	bFGF
T6519	6207-6210	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6518	6087-6090	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6517	5924-5927	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6516	5796-5799	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6515	5579-5582	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6514	5336-5339	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6513	5188-5191	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6512	4902-4905	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6511	4634-4637	http://www.uniprot.org/uniprot/Q9Y243	denotes	Akt
T6459	5579-5582	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6458	5336-5339	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6457	5188-5191	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6456	4902-4905	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6455	4634-4637	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6454	4370-4373	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6453	4240-4243	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6452	4196-4199	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6451	3714-3717	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6450	3015-3018	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6449	2839-2842	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6448	2658-2661	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6447	2395-2398	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6464	36-39	http://www.uniprot.org/uniprot/P31751	denotes	Akt
T6463	6207-6210	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6462	6087-6090	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6461	5924-5927	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6460	5796-5799	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T6531	2450-2454	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T6530	2045-2049	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T6529	983-987	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T6528	765-769	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T6527	645-649	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T6539	5348-5353	http://www.uniprot.org/uniprot/P05412	denotes	c-Jun
T6538	4925-4930	http://www.uniprot.org/uniprot/P05412	denotes	c-Jun
T6537	4082-4087	http://www.uniprot.org/uniprot/P05412	denotes	c-Jun
T6536	3984-3989	http://www.uniprot.org/uniprot/P05412	denotes	c-Jun
T6535	2968-2973	http://www.uniprot.org/uniprot/P05412	denotes	c-Jun
T6534	2924-2927	http://www.uniprot.org/uniprot/Q13451	denotes	p54
T6533	3909-3913	http://www.uniprot.org/uniprot/P01375	denotes	TNFα
T29110	1515-1518	http://www.uniprot.org/uniprot/P31749	denotes	Akt
T29109	1265-1268	http://www.uniprot.org/uniprot/P31749	denotes	Akt

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T28944	1212-1217	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T28943	1174-1179	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T29401	3538-3543	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T29400	3370-3375	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T5279	5716-5721	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T5278	4711-4716	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum
T5277	519-524	http://purl.obolibrary.org/obo/UBERON_0001977	denotes	serum

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T28968	1302-1305	http://purl.obolibrary.org/obo/GO_0004707	denotes	p38
T28967	1286-1289	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T28966	1187-1193	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T28965	1124-1135	http://purl.obolibrary.org/obo/GO_0097528	denotes	Necroptosis
T28964	1076-1087	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T28963	1124-1135	http://purl.obolibrary.org/obo/GO_0070266	denotes	Necroptosis
T28962	1076-1087	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T29417	3175-3186	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T29416	3175-3186	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T29415	3164-3167	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T29414	3137-3152	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5489	6318-6327	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T5488	5641-5656	http://purl.obolibrary.org/obo/GO_0016301	denotes	kinase activity
T5487	4970-4995	http://purl.obolibrary.org/obo/GO_1990089	denotes	response to growth factor
T5486	4970-4995	http://purl.obolibrary.org/obo/GO_0071774	denotes	response to growth factor
T5485	4970-4995	http://purl.obolibrary.org/obo/GO_0070848	denotes	response to growth factor
T5484	4970-4995	http://purl.obolibrary.org/obo/GO_0035728	denotes	response to growth factor
T5483	4970-4995	http://purl.obolibrary.org/obo/GO_0070849	denotes	response to growth factor
T5482	4620-4630	http://purl.obolibrary.org/obo/GO_0065007	denotes	regulation
T5481	6219-6234	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5480	6098-6113	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5479	5946-5961	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5478	5863-5878	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5477	5777-5792	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5476	5354-5369	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5475	5229-5244	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5474	5142-5157	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5473	4883-4898	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5472	4681-4696	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5471	4351-4366	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5470	4259-4274	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5469	4163-4178	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5468	3825-3840	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5467	3718-3733	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5466	2888-2903	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5465	2776-2791	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5464	2662-2677	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5463	2407-2422	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T5462	3645-3661	http://purl.obolibrary.org/obo/GO_0033673	denotes	kinase inhibitor
T5461	1766-1782	http://purl.obolibrary.org/obo/GO_0033673	denotes	kinase inhibitor
T5460	6215-6218	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5459	5587-5590	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5458	5344-5347	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5457	5248-5251	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5456	4917-4920	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5455	4382-4385	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5454	4255-4258	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5453	4203-4206	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5452	3976-3979	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5451	3821-3824	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5450	3023-3026	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5449	2940-2943	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5448	2403-2406	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5447	2334-2337	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5446	699-702	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5445	6259-6269	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T5444	5699-5709	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T5443	2534-2544	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T5442	1884-1894	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T5441	1686-1696	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T5440	466-476	http://purl.obolibrary.org/obo/GO_0008219	denotes	cell death
T5439	873-876	http://purl.obolibrary.org/obo/GO_0004707	denotes	ERK
T5438	865-868	http://purl.obolibrary.org/obo/GO_0004707	denotes	p38
T5437	211-215	http://purl.obolibrary.org/obo/GO_0004707	denotes	MAPK
T5436	6264-6269	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T5435	5704-5709	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T5434	2539-2544	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T5433	1889-1894	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T5432	1691-1696	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T5431	996-1001	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T5430	778-783	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T5429	626-631	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T5428	471-476	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T5427	144-149	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T5426	4982-4988	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T5425	4574-4580	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T5424	600-606	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T5423	394-400	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T5422	276-282	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T5421	94-100	http://purl.obolibrary.org/obo/GO_0040007	denotes	growth
T5420	6039-6050	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T5419	5607-5618	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T5418	4483-4494	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T5417	4282-4293	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T5416	2239-2250	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T5415	2175-2186	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T5414	2004-2015	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T5413	925-936	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T5412	418-429	http://purl.obolibrary.org/obo/GO_0097528	denotes	necroptosis
T5411	55-66	http://purl.obolibrary.org/obo/GO_0097528	denotes	Necroptosis
T5410	6039-6050	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T5409	5607-5618	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T5408	4483-4494	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T5407	4282-4293	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T5406	2239-2250	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T5405	2175-2186	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T5404	2004-2015	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T5403	925-936	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T5402	418-429	http://purl.obolibrary.org/obo/GO_0070266	denotes	necroptosis
T5401	55-66	http://purl.obolibrary.org/obo/GO_0070266	denotes	Necroptosis

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T5509	5641-5656	http://purl.obolibrary.org/obo/GO_0016301	denotes	kinase activity
T5508	6215-6218	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5507	5587-5590	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5506	5344-5347	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5505	5248-5251	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5504	4917-4920	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5503	4382-4385	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5502	4255-4258	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5501	4203-4206	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5500	3976-3979	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5499	3821-3824	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5498	3023-3026	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5497	2940-2943	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5496	2403-2406	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5495	2334-2337	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5494	699-702	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T5493	276-298	http://purl.obolibrary.org/obo/GO_0070851	denotes	growth factor receptor
T5492	873-876	http://purl.obolibrary.org/obo/GO_0004707	denotes	ERK
T5491	865-868	http://purl.obolibrary.org/obo/GO_0004707	denotes	p38
T5490	211-215	http://purl.obolibrary.org/obo/GO_0004707	denotes	MAPK
T28970	1302-1305	http://purl.obolibrary.org/obo/GO_0004707	denotes	p38
T28969	1286-1289	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK
T29420	3624-3634	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies
T29419	3292-3302	http://purl.obolibrary.org/obo/GO_0003823	denotes	antibodies
T29418	3164-3167	http://purl.obolibrary.org/obo/GO_0004705	denotes	JNK

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T28972	1496-1500	http://purl.obolibrary.org/obo/GO_0005623	denotes	Cell
T28971	1335-1339	http://purl.obolibrary.org/obo/GO_0005623	denotes	Cell
T29427	3624-3634	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies
T29426	3292-3302	http://purl.obolibrary.org/obo/GO_0042571	denotes	antibodies
T29425	3624-3634	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T29424	3292-3302	http://purl.obolibrary.org/obo/GO_0019815	denotes	antibodies
T29423	3497-3502	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T29422	3315-3320	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T29421	3197-3202	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T5519	1837-1845	http://purl.obolibrary.org/obo/GO_0016020	denotes	membrane
T5518	6259-6263	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T5517	5699-5703	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T5516	2534-2538	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T5515	2287-2292	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T5514	2100-2105	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T5513	1993-1998	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T5512	736-741	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T5511	589-594	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T5510	383-388	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells

sentences

Id	Subject	Object	Predicate	Lexical cue
T28949	1567-1605	Sentence	denotes	In all graphs, average±SD was plotted.
T28948	1496-1566	Sentence	denotes	Cell viability and Akt expression levels were determined after 24 hrs.
T28947	1335-1495	Sentence	denotes	Cell viability was determined after 24 hrs. (C) L929 cells transfected with Akt1, Akt2, and Akt3 siRNAs for 72 hrs were treated with zVAD.fmk or TNFα for 9 hrs.
T28946	1118-1334	Sentence	denotes	(A,B) Necroptosis was induced by zVAD.fmk or TNFα (full serum, A) or growth factors/zVAD.fmk (serum free, B) in the presence of inhibitors of Akt (Akt inhibitor VIII), JNK (SP600125), p38 (PD169316), and Erk (UO126).
T28945	1057-1117	Sentence	denotes	Akt contributes to necroptosis induced by zVAD.fmk and TNFα.
T29403	3188-3635	Sentence	denotes	(A) L929 cells were treated with zVAD.fmk or TNFα for 9 hr, followed by western blotting with indicated antibodies. (B,C) L929 cells were treated with zVAD.fmk (B) or bFGF/zVAD.fmk (serum free conditions, C) and samples were collected at the indicated time points for western blot. (D) Nec-1 was added to the cells stimulated with bFGF or bFGF/zVAD (serum free conditions) for 15 min or 9 hr followed by western blot with the indicated antibodies.
T29402	3115-3187	Sentence	denotes	RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis.
T5303	4313-4531	Sentence	denotes	Interestingly, we discovered that the phosphorylation of Akt Thr308, JNK and Jun are late events following zVAD.fmk stimulation (Fig. 3B) that coincide with the onset of necroptosis at 6 hr post-stimulation (Fig. S3A).
T5302	4218-4312	Sentence	denotes	This established that Akt Thr308 and JNK phosphorylation during necroptosis is RIP1 dependent.
T5301	4120-4217	Sentence	denotes	Importantly, Nec-1 did not alter the basal phosphorylation levels of either Akt or JNK (Fig. 3A).
T5300	4025-4119	Sentence	denotes	Some of these changes, e.g. zVAD.fmk-induced increase in c-Jun, were also attenuated by Nec-1.
T5299	3924-4024	Sentence	denotes	We observed some changes in total protein levels of JNK and c-Jun following necroptotic stimulation.
T5298	3777-3923	Sentence	denotes	Similarly, Nec-1 prevented the induction of JNK phosphorylation in response to zVAD.fmk and substantially reduced this change after TNFα addition.
T5297	3636-3776	Sentence	denotes	The RIP1 kinase inhibitor, Nec-1, completely prevented the increase in Thr308 Akt phosphorylation, while Nec-1i did not (Fig. 3A, Fig. S1D).
T5296	2985-3070	Sentence	denotes	These data indicate that both Akt and JNK are activated under necroptotic conditions.
T5295	2852-2984	Sentence	denotes	We also observed an increase in the phosphorylation of both the p46 and p54 isoforms of JNK and its major substrate c-Jun (Fig. 3A).
T5294	2730-2851	Sentence	denotes	Interestingly, we did not observe concomitant phosphorylation changes in the second major activation site of Akt, Ser473.
T5293	2574-2729	Sentence	denotes	Following stimulation with either zVAD.fmk or TNFα we observed a robust increase in Akt phosphorylation at a known major activation site, Thr308 (Fig. 3A).
T5292	2468-2573	Sentence	denotes	This time point was chosen because it reflects the early stage of cell death in our system (Fig. S3A, B).
T5291	2294-2467	Sentence	denotes	To understand the activation of Akt and JNK under necroptotic conditions, we examined the changes in Akt and JNK phosphorylation at 9 hrs post zVAD.fmk and TNFα stimulation.
T5290	2188-2293	Sentence	denotes	Our results confirmed that Akt plays a key role in necroptosis induced by multiple stimuli in L929 cells.
T5289	2061-2187	Sentence	denotes	No expression of Akt3 was seen in L929 cells (Fig. S2C) and, consistently, Akt3 siRNA had no additional effect on necroptosis.
T5288	1907-2060	Sentence	denotes	Secondly, simultaneous knockdown of Akt isoforms Akt1 and Akt2 using siRNAs protected cells from necroptosis induced by both zVAD.fmk and TNFα (Fig. 2C).
T5287	1698-1906	Sentence	denotes	First, two additional Akt inhibitors, a highly specific, allosteric kinase inhibitor MK-2206 [25] and triciribine (TCN) [26], which blocks membrane translocation of Akt, both attenuated cell death (Fig. S2B).
T5286	1606-1697	Sentence	denotes	Next, we used two approaches to further validate the role of Akt in necroptotic cell death.
T5285	821-1012	Sentence	denotes	In contrast, inhibition of two other MAPKs, p38 and ERK, previously reported not to be activated during necroptosis [14], did not protect from either zVAD.fmk or TNFα induced death (Fig. 2A).
T5284	661-820	Sentence	denotes	Consistent with previous reports, the JNK inhibitor SP600125 protected the cells from both zVAD.fmk and TNFα induced death (Fig. 2A,B and Fig. S2A) [12], [14].
T5283	552-660	Sentence	denotes	Inhibition of Akt also protected the cells from growth-factor insensitive death by caused by TNFα (Fig. 2A).
T5282	321-551	Sentence	denotes	Inhibition of Akt (Akt inhibitor VIII) strongly protected the cells from growth factor-sensitive necroptosis induced by zVAD.fmk [16] as well as cell death triggered by bFGF or IGF-1/zVAD.fmk under serum free conditions (Fig. 2B).
T5281	67-320	Sentence	denotes	Given our observation that growth factors are important for zVAD.fmk induced death, we examined the contribution of several pathways, including MAPK pathways and Akt, which are known to be activated following growth factor receptor activation (Fig. 2A).
T5309	6129-6356	Sentence	denotes	Taken together, these results indicate that the observed delayed increases in Akt and JNK phosphorylation, preceding the onset of cell death, represent specific consequences of necroptotic signaling downstream from RIP1 kinase.
T5308	5891-6128	Sentence	denotes	We confirmed the kinetics of the Akt Thr308 and Ser473 phosphorylation changes using a quantitative ELISA assay, which also showed a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation (Fig. S3D, E).
T5307	5658-5890	Sentence	denotes	Similarly, IGF/zVAD, which also promoted cell death under serum free conditions, produced a delayed increase in Thr308 phosphorylation on Akt, while IGF alone caused solely an early, transient increase in phosphorylation (Fig. S3C).
T5306	5019-5657	Sentence	denotes	Significantly, the combination of bFGF/zVAD.fmk, but not bFGF alone, also caused a robust, second, delayed increase in the phosphorylation of Thr308, but not Ser473, of Akt as well as a delayed increase in the phosphorylation of JNK and Jun. Furthermore, Nec-1 had no significant effect on the early increase in both Akt and JNK/c-Jun phosphorylation triggered by both bFGF and bFGF/zVAD, while Nec-1, but not its inactive analog Nec-1i (Fig. S1E), efficiently blocked the bFGF/zVAD increase at 6–9 hr (Fig. 3D), suggesting that only the delayed activation of Akt and JNK is specific for necroptosis and dependent on RIP1 kinase activity.
T5305	4734-5018	Sentence	denotes	We found that the addition of bFGF alone or in combination with zVAD.fmk led to a substantial rapid and transient increase in both Thr308 and Ser473 phosphorylation of Akt as well as JNK and c-Jun at 15 minutes, reflecting the expected response to growth factor stimulation (Fig. 3C).
T5304	4532-4733	Sentence	denotes	To better understand the contributions of growth factors and RIP1 kinase to necroptotic regulation of Akt, we next analyzed the time course of these phosphorylation changes under serum free conditions.
T64	0-66	Sentence	denotes	RIP1 Kinase-dependent Activation of Akt Contributes to Necroptosis
T65	67-320	Sentence	denotes	Given our observation that growth factors are important for zVAD.fmk induced death, we examined the contribution of several pathways, including MAPK pathways and Akt, which are known to be activated following growth factor receptor activation (Fig. 2A).
T66	321-551	Sentence	denotes	Inhibition of Akt (Akt inhibitor VIII) strongly protected the cells from growth factor-sensitive necroptosis induced by zVAD.fmk [16] as well as cell death triggered by bFGF or IGF-1/zVAD.fmk under serum free conditions (Fig. 2B).
T67	552-660	Sentence	denotes	Inhibition of Akt also protected the cells from growth-factor insensitive death by caused by TNFα (Fig. 2A).
T68	661-820	Sentence	denotes	Consistent with previous reports, the JNK inhibitor SP600125 protected the cells from both zVAD.fmk and TNFα induced death (Fig. 2A,B and Fig. S2A) [12], [14].
T69	821-1012	Sentence	denotes	In contrast, inhibition of two other MAPKs, p38 and ERK, previously reported not to be activated during necroptosis [14], did not protect from either zVAD.fmk or TNFα induced death (Fig. 2A).
T70	1013-1117	Sentence	denotes	10.1371/journal.pone.0056576.g002 Figure 2 Akt contributes to necroptosis induced by zVAD.fmk and TNFα.
T71	1118-1334	Sentence	denotes	(A,B) Necroptosis was induced by zVAD.fmk or TNFα (full serum, A) or growth factors/zVAD.fmk (serum free, B) in the presence of inhibitors of Akt (Akt inhibitor VIII), JNK (SP600125), p38 (PD169316), and Erk (UO126).
T72	1335-1495	Sentence	denotes	Cell viability was determined after 24 hrs. (C) L929 cells transfected with Akt1, Akt2, and Akt3 siRNAs for 72 hrs were treated with zVAD.fmk or TNFα for 9 hrs.
T73	1496-1566	Sentence	denotes	Cell viability and Akt expression levels were determined after 24 hrs.
T74	1567-1605	Sentence	denotes	In all graphs, average±SD was plotted.
T75	1606-1697	Sentence	denotes	Next, we used two approaches to further validate the role of Akt in necroptotic cell death.
T76	1698-1906	Sentence	denotes	First, two additional Akt inhibitors, a highly specific, allosteric kinase inhibitor MK-2206 [25] and triciribine (TCN) [26], which blocks membrane translocation of Akt, both attenuated cell death (Fig. S2B).
T77	1907-2060	Sentence	denotes	Secondly, simultaneous knockdown of Akt isoforms Akt1 and Akt2 using siRNAs protected cells from necroptosis induced by both zVAD.fmk and TNFα (Fig. 2C).
T78	2061-2187	Sentence	denotes	No expression of Akt3 was seen in L929 cells (Fig. S2C) and, consistently, Akt3 siRNA had no additional effect on necroptosis.
T79	2188-2293	Sentence	denotes	Our results confirmed that Akt plays a key role in necroptosis induced by multiple stimuli in L929 cells.
T80	2294-2467	Sentence	denotes	To understand the activation of Akt and JNK under necroptotic conditions, we examined the changes in Akt and JNK phosphorylation at 9 hrs post zVAD.fmk and TNFα stimulation.
T81	2468-2573	Sentence	denotes	This time point was chosen because it reflects the early stage of cell death in our system (Fig. S3A, B).
T82	2574-2729	Sentence	denotes	Following stimulation with either zVAD.fmk or TNFα we observed a robust increase in Akt phosphorylation at a known major activation site, Thr308 (Fig. 3A).
T83	2730-2851	Sentence	denotes	Interestingly, we did not observe concomitant phosphorylation changes in the second major activation site of Akt, Ser473.
T84	2852-2984	Sentence	denotes	We also observed an increase in the phosphorylation of both the p46 and p54 isoforms of JNK and its major substrate c-Jun (Fig. 3A).
T85	2985-3070	Sentence	denotes	These data indicate that both Akt and JNK are activated under necroptotic conditions.
T86	3071-3187	Sentence	denotes	10.1371/journal.pone.0056576.g003 Figure 3 RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis.
T87	3188-3635	Sentence	denotes	(A) L929 cells were treated with zVAD.fmk or TNFα for 9 hr, followed by western blotting with indicated antibodies. (B,C) L929 cells were treated with zVAD.fmk (B) or bFGF/zVAD.fmk (serum free conditions, C) and samples were collected at the indicated time points for western blot. (D) Nec-1 was added to the cells stimulated with bFGF or bFGF/zVAD (serum free conditions) for 15 min or 9 hr followed by western blot with the indicated antibodies.
T88	3636-3776	Sentence	denotes	The RIP1 kinase inhibitor, Nec-1, completely prevented the increase in Thr308 Akt phosphorylation, while Nec-1i did not (Fig. 3A, Fig. S1D).
T89	3777-3923	Sentence	denotes	Similarly, Nec-1 prevented the induction of JNK phosphorylation in response to zVAD.fmk and substantially reduced this change after TNFα addition.
T90	3924-4024	Sentence	denotes	We observed some changes in total protein levels of JNK and c-Jun following necroptotic stimulation.
T91	4025-4119	Sentence	denotes	Some of these changes, e.g. zVAD.fmk-induced increase in c-Jun, were also attenuated by Nec-1.
T92	4120-4217	Sentence	denotes	Importantly, Nec-1 did not alter the basal phosphorylation levels of either Akt or JNK (Fig. 3A).
T93	4218-4312	Sentence	denotes	This established that Akt Thr308 and JNK phosphorylation during necroptosis is RIP1 dependent.
T94	4313-4531	Sentence	denotes	Interestingly, we discovered that the phosphorylation of Akt Thr308, JNK and Jun are late events following zVAD.fmk stimulation (Fig. 3B) that coincide with the onset of necroptosis at 6 hr post-stimulation (Fig. S3A).
T95	4532-4733	Sentence	denotes	To better understand the contributions of growth factors and RIP1 kinase to necroptotic regulation of Akt, we next analyzed the time course of these phosphorylation changes under serum free conditions.
T96	4734-5018	Sentence	denotes	We found that the addition of bFGF alone or in combination with zVAD.fmk led to a substantial rapid and transient increase in both Thr308 and Ser473 phosphorylation of Akt as well as JNK and c-Jun at 15 minutes, reflecting the expected response to growth factor stimulation (Fig. 3C).
T97	5019-5260	Sentence	denotes	Significantly, the combination of bFGF/zVAD.fmk, but not bFGF alone, also caused a robust, second, delayed increase in the phosphorylation of Thr308, but not Ser473, of Akt as well as a delayed increase in the phosphorylation of JNK and Jun.
T98	5261-5657	Sentence	denotes	Furthermore, Nec-1 had no significant effect on the early increase in both Akt and JNK/c-Jun phosphorylation triggered by both bFGF and bFGF/zVAD, while Nec-1, but not its inactive analog Nec-1i (Fig. S1E), efficiently blocked the bFGF/zVAD increase at 6–9 hr (Fig. 3D), suggesting that only the delayed activation of Akt and JNK is specific for necroptosis and dependent on RIP1 kinase activity.
T99	5658-5890	Sentence	denotes	Similarly, IGF/zVAD, which also promoted cell death under serum free conditions, produced a delayed increase in Thr308 phosphorylation on Akt, while IGF alone caused solely an early, transient increase in phosphorylation (Fig. S3C).
T100	5891-6128	Sentence	denotes	We confirmed the kinetics of the Akt Thr308 and Ser473 phosphorylation changes using a quantitative ELISA assay, which also showed a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation (Fig. S3D, E).
T101	6129-6356	Sentence	denotes	Taken together, these results indicate that the observed delayed increases in Akt and JNK phosphorylation, preceding the onset of cell death, represent specific consequences of necroptotic signaling downstream from RIP1 kinase.

simple1

Id	Subject	Object	Predicate	Lexical cue
T28984	1480-1484	Protein	denotes	TNFα
T28983	1427-1438	Protein	denotes	Akt3 siRNAs
T28982	1417-1421	Protein	denotes	Akt2
T28981	1411-1415	Protein	denotes	Akt1
T28980	1163-1167	Protein	denotes	TNFα
T28979	1112-1116	Protein	denotes	TNFα
T29437	3527-3531	Protein	denotes	bFGF
T29436	3519-3523	Protein	denotes	bFGF
T29435	3355-3359	Protein	denotes	bFGF
T29434	3233-3237	Protein	denotes	TNFα
T29433	3115-3119	Protein	denotes	RIP1
T5553	6344-6348	Protein	denotes	RIP1
T5552	6060-6064	Protein	denotes	RIP1
T5551	5636-5640	Protein	denotes	RIP1
T5550	5492-5496	Protein	denotes	bFGF
T5549	5397-5401	Protein	denotes	bFGF
T5548	5388-5392	Protein	denotes	bFGF
T5547	5348-5353	Protein	denotes	c-Jun
T5546	5076-5080	Protein	denotes	bFGF
T5545	5053-5057	Protein	denotes	bFGF
T5544	4925-4930	Protein	denotes	c-Jun
T5543	4764-4768	Protein	denotes	bFGF
T5542	4593-4597	Protein	denotes	RIP1
T5541	4297-4301	Protein	denotes	RIP1
T5540	4082-4087	Protein	denotes	c-Jun
T5539	3984-3989	Protein	denotes	c-Jun
T5538	3909-3913	Protein	denotes	TNFα
T5537	3714-3717	Protein	denotes	Akt
T5536	3640-3644	Protein	denotes	RIP1
T5535	2968-2973	Protein	denotes	c-Jun
T5534	2924-2927	Protein	denotes	p54
T5533	2916-2919	Protein	denotes	p46
T5532	2620-2624	Protein	denotes	TNFα
T5531	2450-2454	Protein	denotes	TNFα
T5530	2136-2146	Protein	denotes	Akt3 siRNA
T5529	2078-2082	Protein	denotes	Akt3
T5528	2045-2049	Protein	denotes	TNFα
T5527	1965-1969	Protein	denotes	Akt2
T5526	1956-1960	Protein	denotes	Akt1
T5525	983-987	Protein	denotes	TNFα
T5524	765-769	Protein	denotes	TNFα
T5523	645-649	Protein	denotes	TNFα
T5522	498-503	Protein	denotes	IGF-1
T5521	490-494	Protein	denotes	bFGF

BioNLP16_DUT

Id	Subject	Object	Predicate	Lexical cue
T29648	3120-3136	Regulation	denotes	kinase-dependent
T29647	3137-3152	Phosphorylation	denotes	phosphorylation
T29646	3527-3531	Protein	denotes	bFGF
T29645	3519-3523	Protein	denotes	bFGF
T29644	3355-3359	Protein	denotes	bFGF
T29643	3233-3237	Protein	denotes	TNFα
T29642	3115-3119	Protein	denotes	RIP1
T29106	1394-1405	Gene_expression	denotes	transfected
T29105	1480-1484	Protein	denotes	TNFα
T29104	1427-1438	Protein	denotes	Akt3 siRNAs
T29103	1417-1421	Protein	denotes	Akt2
T29102	1411-1415	Protein	denotes	Akt1
T29101	1163-1167	Protein	denotes	TNFα
T29100	1112-1116	Protein	denotes	TNFα
T6428	5480-5487	Negative_regulation	denotes	blocked
T6427	5319-5327	Positive_regulation	denotes	increase
T6426	5623-5632	Positive_regulation	denotes	dependent
T6425	5502-5510	Positive_regulation	denotes	increase
T6424	5354-5369	Phosphorylation	denotes	phosphorylation
T6423	4848-4856	Positive_regulation	denotes	increase
T6422	4070-4078	Positive_regulation	denotes	increase
T6421	3941-3948	Regulation	denotes	changes
T6420	3652-3661	Negative_regulation	denotes	inhibitor
T6419	3695-3703	Positive_regulation	denotes	increase
T6418	3718-3733	Phosphorylation	denotes	phosphorylation
T6417	3681-3690	Negative_regulation	denotes	prevented
T6416	2872-2880	Positive_regulation	denotes	increase
T6415	2888-2903	Phosphorylation	denotes	phosphorylation
T6414	2064-2074	Gene_expression	denotes	expression
T6413	1930-1939	Negative_regulation	denotes	knockdown
T6412	6344-6348	Protein	denotes	RIP1
T6382	645-649	Protein	denotes	TNFα
T6381	498-503	Protein	denotes	IGF-1
T6380	490-494	Protein	denotes	bFGF
T6410	5636-5640	Protein	denotes	RIP1
T6409	5492-5496	Protein	denotes	bFGF
T6408	5397-5401	Protein	denotes	bFGF
T6407	5388-5392	Protein	denotes	bFGF
T6406	5348-5353	Protein	denotes	c-Jun
T6405	5076-5080	Protein	denotes	bFGF
T6404	5053-5057	Protein	denotes	bFGF
T6403	4925-4930	Protein	denotes	c-Jun
T6402	4764-4768	Protein	denotes	bFGF
T6401	4593-4597	Protein	denotes	RIP1
T6400	4297-4301	Protein	denotes	RIP1
T6399	4082-4087	Protein	denotes	c-Jun
T6398	3984-3989	Protein	denotes	c-Jun
T6397	3909-3913	Protein	denotes	TNFα
T6396	3714-3717	Protein	denotes	Akt
T6395	3640-3644	Protein	denotes	RIP1
T6394	2968-2973	Protein	denotes	c-Jun
T6393	2924-2927	Protein	denotes	p54
T6392	2916-2919	Protein	denotes	p46
T6391	2620-2624	Protein	denotes	TNFα
T6390	2450-2454	Protein	denotes	TNFα
T6389	2136-2146	Protein	denotes	Akt3 siRNA
T6388	2078-2082	Protein	denotes	Akt3
T6387	2045-2049	Protein	denotes	TNFα
T6386	1965-1969	Protein	denotes	Akt2
T6385	1956-1960	Protein	denotes	Akt1
T6384	983-987	Protein	denotes	TNFα
T6383	765-769	Protein	denotes	TNFα
T6411	6060-6064	Protein	denotes	RIP1
R4400	T6385	T6413	themeOf	Akt1,knockdown
R4401	T6386	T6413	themeOf	Akt2,knockdown
R4402	T6388	T6414	themeOf	Akt3,expression
R4403	T6392	T6415	themeOf	p46,phosphorylation
R4404	T6393	T6415	themeOf	p54,phosphorylation
R4405	T6394	T6415	themeOf	c-Jun,phosphorylation
R4406	T6394	T6416	themeOf	c-Jun,increase
R4407	T6395	T6420	themeOf	RIP1,inhibitor
R4408	T6396	T6418	themeOf	Akt,phosphorylation
R4409	T6398	T6421	themeOf	c-Jun,changes
R4410	T6399	T6422	themeOf	c-Jun,increase
R4411	T6403	T6423	themeOf	c-Jun,increase
R4412	T6406	T6424	themeOf	c-Jun,phosphorylation
R4413	T6409	T6425	themeOf	bFGF,increase
R4414	T6410	T6426	themeOf	RIP1,dependent
R4415	T6415	T6416	themeOf	phosphorylation,increase
R4416	T6415	T6416	themeOf	phosphorylation,increase
R4417	T6415	T6416	themeOf	phosphorylation,increase
R4418	T6418	T6419	themeOf	phosphorylation,increase
R4419	T6419	T6417	themeOf	increase,prevented
R4420	T6424	T6427	themeOf	phosphorylation,increase
R4421	T6425	T6428	themeOf	increase,blocked
R20182	T29102	T29106	themeOf	Akt1,transfected
R20183	T29103	T29106	themeOf	Akt2,transfected
R20184	T29104	T29106	themeOf	Akt3 siRNAs,transfected
R20562	T29642	T29647	themeOf	RIP1,phosphorylation
R20563	T29647	T29648	themeOf	phosphorylation,kinase-dependent

BioNLP16_Messiy

Id	Subject	Object	Predicate	Lexical cue
T29677	3137-3152	Phosphorylation	denotes	phosphorylation
T29676	3120-3136	Regulation	denotes	kinase-dependent
T29675	3527-3531	Protein	denotes	bFGF
T29674	3519-3523	Protein	denotes	bFGF
T29673	3355-3359	Protein	denotes	bFGF
T29672	3233-3237	Protein	denotes	TNFα
T6708	5502-5510	Positive_regulation	denotes	increase
T6707	5480-5487	Negative_regulation	denotes	blocked
T6706	4070-4078	Positive_regulation	denotes	increase
T6705	3941-3948	Regulation	denotes	changes
T6704	3718-3733	Phosphorylation	denotes	phosphorylation
T6703	3681-3690	Negative_regulation	denotes	prevented
T6702	3652-3661	Negative_regulation	denotes	inhibitor
T6701	3695-3703	Positive_regulation	denotes	increase
T6700	2872-2880	Positive_regulation	denotes	increase
T6699	2888-2903	Phosphorylation	denotes	phosphorylation
T6698	2064-2074	Gene_expression	denotes	expression
T6697	1930-1939	Negative_regulation	denotes	knockdown
T6696	2016-2023	Positive_regulation	denotes	induced
T6695	988-995	Positive_regulation	denotes	induced
T6693	6344-6348	Protein	denotes	RIP1
T6692	6060-6064	Protein	denotes	RIP1
T6691	5636-5640	Protein	denotes	RIP1
T6690	5492-5496	Protein	denotes	bFGF
T6689	5397-5401	Protein	denotes	bFGF
T6688	5388-5392	Protein	denotes	bFGF
T6673	2916-2919	Protein	denotes	p46
T6672	2620-2624	Protein	denotes	TNFα
T6671	2450-2454	Protein	denotes	TNFα
T6670	2136-2146	Protein	denotes	Akt3 siRNA
T6669	2078-2082	Protein	denotes	Akt3
T6668	2045-2049	Protein	denotes	TNFα
T6667	1965-1969	Protein	denotes	Akt2
T6666	1956-1960	Protein	denotes	Akt1
T6665	983-987	Protein	denotes	TNFα
T6664	765-769	Protein	denotes	TNFα
T6663	645-649	Protein	denotes	TNFα
T6662	498-503	Protein	denotes	IGF-1
T6661	490-494	Protein	denotes	bFGF
T6687	5348-5353	Protein	denotes	c-Jun
T6686	5076-5080	Protein	denotes	bFGF
T6685	5053-5057	Protein	denotes	bFGF
T6684	4925-4930	Protein	denotes	c-Jun
T6683	4764-4768	Protein	denotes	bFGF
T6682	4593-4597	Protein	denotes	RIP1
T6681	4297-4301	Protein	denotes	RIP1
T6680	4082-4087	Protein	denotes	c-Jun
T6679	3984-3989	Protein	denotes	c-Jun
T6678	3909-3913	Protein	denotes	TNFα
T6677	3714-3717	Protein	denotes	Akt
T6676	3640-3644	Protein	denotes	RIP1
T6675	2968-2973	Protein	denotes	c-Jun
T6674	2924-2927	Protein	denotes	p54
T29671	3115-3119	Protein	denotes	RIP1
T29143	1394-1405	Gene_expression	denotes	transfected
T29142	1088-1095	Positive_regulation	denotes	induced
T29141	1480-1484	Protein	denotes	TNFα
T29140	1427-1438	Protein	denotes	Akt3 siRNAs
T29139	1417-1421	Protein	denotes	Akt2
T29138	1411-1415	Protein	denotes	Akt1
T29137	1163-1167	Protein	denotes	TNFα
T29136	1112-1116	Protein	denotes	TNFα
R4479	T6665	T6695	themeOf	TNFα,induced
R4480	T6666	T6697	themeOf	Akt1,knockdown
R4481	T6667	T6697	themeOf	Akt2,knockdown
R4482	T6668	T6696	themeOf	TNFα,induced
R4483	T6669	T6698	themeOf	Akt3,expression
R4484	T6673	T6699	themeOf	p46,phosphorylation
R4485	T6674	T6699	themeOf	p54,phosphorylation
R4486	T6675	T6699	themeOf	c-Jun,phosphorylation
R4487	T6676	T6702	themeOf	RIP1,inhibitor
R4488	T6677	T6704	themeOf	Akt,phosphorylation
R4489	T6679	T6705	themeOf	c-Jun,changes
R4490	T6680	T6706	themeOf	c-Jun,increase
R4491	T6690	T6708	themeOf	bFGF,increase
R4492	T6699	T6700	themeOf	phosphorylation,increase
R4493	T6699	T6700	themeOf	phosphorylation,increase
R4494	T6699	T6700	themeOf	phosphorylation,increase
R4495	T6701	T6703	themeOf	increase,prevented
R4496	T6702	T6703	causeOf	inhibitor,prevented
R4497	T6704	T6701	themeOf	phosphorylation,increase
R4498	T6708	T6707	themeOf	increase,blocked
R20189	T29136	T29142	themeOf	TNFα,induced
R20190	T29138	T29143	themeOf	Akt1,transfected
R20191	T29139	T29143	themeOf	Akt2,transfected
R20568	T29671	T29677	themeOf	RIP1,phosphorylation
R20569	T29677	T29676	themeOf	phosphorylation,kinase-dependent

DLUT931

Id	Subject	Object	Predicate	Lexical cue
T29662	3137-3152	Phosphorylation	denotes	phosphorylation
T29661	3527-3531	Protein	denotes	bFGF
T29660	3519-3523	Protein	denotes	bFGF
T29659	3355-3359	Protein	denotes	bFGF
T29658	3233-3237	Protein	denotes	TNFα
T29657	3115-3119	Protein	denotes	RIP1
T29128	1394-1405	Gene_expression	denotes	transfected
T29127	1480-1484	Protein	denotes	TNFα
T29126	1427-1438	Protein	denotes	Akt3 siRNAs
T29125	1417-1421	Protein	denotes	Akt2
T29124	1411-1415	Protein	denotes	Akt1
T29123	1163-1167	Protein	denotes	TNFα
T29122	1112-1116	Protein	denotes	TNFα
T6593	5480-5487	Negative_regulation	denotes	blocked
T6592	5502-5510	Positive_regulation	denotes	increase
T6591	5370-5379	Positive_regulation	denotes	triggered
T6590	5354-5369	Phosphorylation	denotes	phosphorylation
T6589	4848-4856	Positive_regulation	denotes	increase
T6588	4752-4760	Negative_regulation	denotes	addition
T6587	4053-4069	Positive_regulation	denotes	zVAD.fmk-induced
T6586	4070-4078	Positive_regulation	denotes	increase
T6585	3941-3948	Regulation	denotes	changes
T6584	3681-3690	Negative_regulation	denotes	prevented
T6583	3695-3703	Positive_regulation	denotes	increase
T6582	3718-3733	Phosphorylation	denotes	phosphorylation
T6581	3652-3661	Negative_regulation	denotes	inhibitor
T6580	2872-2880	Positive_regulation	denotes	increase
T6579	2888-2903	Phosphorylation	denotes	phosphorylation
T6578	2608-2616	Positive_regulation	denotes	zVAD.fmk
T6577	2064-2074	Gene_expression	denotes	expression
T6576	1976-1982	Negative_regulation	denotes	siRNAs
T6575	1930-1939	Negative_regulation	denotes	knockdown
T6574	988-995	Positive_regulation	denotes	induced
T6573	6344-6348	Protein	denotes	RIP1
T6572	6060-6064	Protein	denotes	RIP1
T6571	5636-5640	Protein	denotes	RIP1
T6570	5492-5496	Protein	denotes	bFGF
T6564	4925-4930	Protein	denotes	c-Jun
T6563	4764-4768	Protein	denotes	bFGF
T6562	4593-4597	Protein	denotes	RIP1
T6561	4297-4301	Protein	denotes	RIP1
T6560	4082-4087	Protein	denotes	c-Jun
T6559	3984-3989	Protein	denotes	c-Jun
T6558	3909-3913	Protein	denotes	TNFα
T6557	3714-3717	Protein	denotes	Akt
T6556	3640-3644	Protein	denotes	RIP1
T6555	2968-2973	Protein	denotes	c-Jun
T6554	2924-2927	Protein	denotes	p54
T6553	2916-2919	Protein	denotes	p46
T6552	2620-2624	Protein	denotes	TNFα
T6551	2450-2454	Protein	denotes	TNFα
T6550	2136-2146	Protein	denotes	Akt3 siRNA
T6549	2078-2082	Protein	denotes	Akt3
T6548	2045-2049	Protein	denotes	TNFα
T6547	1965-1969	Protein	denotes	Akt2
T6546	1956-1960	Protein	denotes	Akt1
T6545	983-987	Protein	denotes	TNFα
T6544	765-769	Protein	denotes	TNFα
T6543	645-649	Protein	denotes	TNFα
T6542	498-503	Protein	denotes	IGF-1
T6541	490-494	Protein	denotes	bFGF
T6569	5397-5401	Protein	denotes	bFGF
T6568	5388-5392	Protein	denotes	bFGF
T6567	5348-5353	Protein	denotes	c-Jun
T6566	5076-5080	Protein	denotes	bFGF
T6565	5053-5057	Protein	denotes	bFGF
T29663	3120-3136	Regulation	denotes	kinase-dependent
R4422	T6545	T6574	themeOf	TNFα,induced
R4423	T6546	T6575	themeOf	Akt1,knockdown
R4424	T6546	T6576	themeOf	Akt1,siRNAs
R4425	T6547	T6575	themeOf	Akt2,knockdown
R4426	T6547	T6576	themeOf	Akt2,siRNAs
R4427	T6549	T6577	themeOf	Akt3,expression
R4428	T6552	T6578	themeOf	TNFα,zVAD.fmk
R4429	T6553	T6579	themeOf	p46,phosphorylation
R4430	T6554	T6579	themeOf	p54,phosphorylation
R4431	T6555	T6579	themeOf	c-Jun,phosphorylation
R4432	T6556	T6581	themeOf	RIP1,inhibitor
R4433	T6557	T6582	themeOf	Akt,phosphorylation
R4434	T6559	T6585	themeOf	c-Jun,changes
R4435	T6560	T6586	themeOf	c-Jun,increase
R4436	T6563	T6588	themeOf	bFGF,addition
R4437	T6564	T6589	themeOf	c-Jun,increase
R4438	T6567	T6590	themeOf	c-Jun,phosphorylation
R4439	T6568	T6591	themeOf	bFGF,triggered
R4440	T6569	T6591	causeOf	bFGF,triggered
R4441	T6570	T6592	themeOf	bFGF,increase
R4442	T6576	T6575	themeOf	siRNAs,knockdown
R4443	T6576	T6575	themeOf	siRNAs,knockdown
R4444	T6579	T6580	themeOf	phosphorylation,increase
R4445	T6579	T6580	themeOf	phosphorylation,increase
R4446	T6579	T6580	themeOf	phosphorylation,increase
R4447	T6581	T6584	causeOf	inhibitor,prevented
R4448	T6582	T6583	themeOf	phosphorylation,increase
R4449	T6583	T6584	themeOf	increase,prevented
R4450	T6586	T6587	themeOf	increase,zVAD.fmk-induced
R4451	T6587	T6586	themeOf	zVAD.fmk-induced,increase
R4452	T6592	T6593	themeOf	increase,blocked
R20185	T29124	T29128	themeOf	Akt1,transfected
R20186	T29125	T29128	themeOf	Akt2,transfected
R20187	T29126	T29128	themeOf	Akt3 siRNAs,transfected
R20564	T29657	T29662	themeOf	RIP1,phosphorylation
R20565	T29662	T29663	themeOf	phosphorylation,kinase-dependent

bionlp-st-ge-2016-test-ihmc

Id	Subject	Object	Predicate	Lexical cue
T29370	1515-1536	Gene_expression	denotes	Akt expression levels
T29369	1489-1494	Protein	denotes	9 hrs
T29368	1202-1210	Entity	denotes	zVAD.fmk
T29367	1383-1449	Entity	denotes	L929 cells transfected with Akt1, Akt2, and Akt3 siRNAs for 72 hrs
T29366	1496-1510	Entity	denotes	Cell viability
T29365	1260-1289	Protein	denotes	Akt (Akt inhibitor VIII), JNK
T29364	1417-1421	Protein	denotes	Akt2
T29363	1443-1449	Protein	denotes	72 hrs
T29362	1163-1167	Protein	denotes	TNFα
T29361	1260-1285	Protein	denotes	Akt (Akt inhibitor VIII),
T29360	1057-1060	Protein	denotes	Akt
T29359	1302-1305	Protein	denotes	p38
T29358	1099-1107	Entity	denotes	zVAD.fmk
T29357	1371-1377	Protein	denotes	24 hrs
T29356	1265-1283	Entity	denotes	Akt inhibitor VIII
T29355	1515-1518	Protein	denotes	Akt
T29354	1559-1565	Protein	denotes	24 hrs
T29353	1246-1289	Entity	denotes	inhibitors of Akt (Akt inhibitor VIII), JNK
T29352	1468-1476	Entity	denotes	zVAD.fmk
T29351	1411-1415	Protein	denotes	Akt1
T29350	1151-1159	Entity	denotes	zVAD.fmk
T29349	1427-1438	Protein	denotes	Akt3 siRNAs
T29348	1383-1387	Entity	denotes	L929
T29347	1480-1494	Protein	denotes	TNFα for 9 hrs
T29346	1112-1116	Protein	denotes	TNFα
T29345	1322-1325	Protein	denotes	Erk
T29720	3115-3186	Phosphorylation	denotes	RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
T29719	3115-3186	Phosphorylation	denotes	RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
T29718	3115-3186	Regulation	denotes	RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
T29717	3115-3186	Regulation	denotes	RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
T29716	3474-3479	Protein	denotes	Nec-1
T29715	3527-3531	Protein	denotes	bFGF
T29714	3233-3276	Protein	denotes	TNFα for 9 hr, followed by western blotting
T29713	3519-3523	Protein	denotes	bFGF
T29712	3339-3351	Entity	denotes	zVAD.fmk (B)
T29711	3292-3302	Entity	denotes	antibodies
T29710	3360-3368	Entity	denotes	zVAD.fmk
T29709	3120-3136	Protein	denotes	kinase-dependent
T29708	3221-3229	Entity	denotes	zVAD.fmk
T29707	3115-3119	Protein	denotes	RIP1
T29706	3156-3159	Protein	denotes	Akt
T29705	3164-3167	Protein	denotes	JNK
T29704	3355-3359	Protein	denotes	bFGF
T29703	3624-3634	Entity	denotes	antibodies
T29702	3490-3531	Entity	denotes	to the cells stimulated with bFGF or bFGF
T7309	6215-6235	Phosphorylation	denotes	JNK phosphorylation,
T7308	4347-4402	Phosphorylation	denotes	the phosphorylation of Akt Thr308, JNK and Jun are late
T7307	3663-3734	Negative_regulation	denotes	Nec-1, completely prevented the increase in Thr308 Akt phosphorylation,
T7306	2308-2337	Positive_regulation	denotes	the activation of Akt and JNK
T7305	2308-2337	Positive_regulation	denotes	the activation of Akt and JNK
T7304	4608-4637	Regulation	denotes	necroptotic regulation of Akt
T7303	3704-3733	Phosphorylation	denotes	in Thr308 Akt phosphorylation
T7302	256-309	Positive_regulation	denotes	activated following growth factor receptor activation
T7301	3691-3734	Positive_regulation	denotes	the increase in Thr308 Akt phosphorylation,
T7300	6004-6113	Positive_regulation	denotes	which also showed a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation
T7299	2574-2677	Positive_regulation	denotes	Following stimulation with either zVAD.fmk or TNFα we observed a robust increase in Akt phosphorylation
T7298	2985-3069	Positive_regulation	denotes	These data indicate that both Akt and JNK are activated under necroptotic conditions
T7297	2985-3069	Positive_regulation	denotes	These data indicate that both Akt and JNK are activated under necroptotic conditions
T7296	4255-4274	Phosphorylation	denotes	JNK phosphorylation
T7295	6022-6113	Regulation	denotes	a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation
T7294	22-39	Positive_regulation	denotes	Activation of Akt
T7293	321-359	Negative_regulation	denotes	Inhibition of Akt (Akt inhibitor VIII)
T7292	3818-3840	Phosphorylation	denotes	of JNK phosphorylation
T7291	552-569	Negative_regulation	denotes	Inhibition of Akt
T7290	5748-5800	Negative_regulation	denotes	a delayed increase in Thr308 phosphorylation on Akt,
T7289	1824-1867	Negative_regulation	denotes	which blocks membrane translocation of Akt,
T7288	6084-6113	Phosphorylation	denotes	in Akt Thr308 phosphorylation
T7287	2403-2422	Phosphorylation	denotes	JNK phosphorylation
T7286	2655-2677	Phosphorylation	denotes	in Akt phosphorylation
T7285	5553-5590	Positive_regulation	denotes	the delayed activation of Akt and JNK
T7284	5553-5590	Positive_regulation	denotes	the delayed activation of Akt and JNK
T7283	6022-6113	Negative_regulation	denotes	a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation
T7282	834-863	Negative_regulation	denotes	inhibition of two other MAPKs
T7281	2450-2466	Positive_regulation	denotes	TNFα stimulation
T7280	5748-5800	Positive_regulation	denotes	a delayed increase in Thr308 phosphorylation on Akt,
T7279	2061-2116	Gene_expression	denotes	No expression of Akt3 was seen in L929 cells (Fig. S2C)
T7278	5553-5590	Negative_regulation	denotes	the delayed activation of Akt and JNK
T7277	5553-5590	Negative_regulation	denotes	the delayed activation of Akt and JNK
T7276	2450-2454	Protein	denotes	TNFα
T7275	765-769	Protein	denotes	TNFα
T7274	542-545	Protein	denotes	Fig
T7273	1720-1723	Protein	denotes	Akt
T7272	983-987	Protein	denotes	TNFα
T7271	563-569	Protein	denotes	of Akt
T7270	5770-5776	Entity	denotes	Thr308
T7269	4203-4216	Protein	denotes	JNK (Fig. 3A)
T7268	332-338	Protein	denotes	of Akt
T7267	3788-3793	Protein	denotes	Nec-1
T7266	5924-5927	Protein	denotes	Akt
T7265	290-298	Protein	denotes	receptor
T7264	379-454	Entity	denotes	the cells from growth factor-sensitive necroptosis induced by zVAD.fmk [16]
T7263	4079-4088	Protein	denotes	in c-Jun,
T7262	340-358	Entity	denotes	Akt inhibitor VIII
T7261	4593-4597	Protein	denotes	RIP1
T7260	752-760	Entity	denotes	zVAD.fmk
T7259	799-802	Protein	denotes	Fig
T7258	4244-4250	Entity	denotes	Thr308
T7257	4110-4118	Protein	denotes	by Nec-1
T7256	1965-1982	Protein	denotes	Akt2 using siRNAs
T7255	4053-4069	Entity	denotes	zVAD.fmk-induced
T7254	4631-4637	Protein	denotes	of Akt
T7253	3663-3668	Protein	denotes	Nec-1
T7252	1745-1795	Entity	denotes	specific, allosteric kinase inhibitor MK-2206 [25]
T7251	2706-2710	Entity	denotes	site
T7250	865-868	Protein	denotes	p38
T7249	2045-2049	Protein	denotes	TNFα
T7248	4865-4871	Entity	denotes	Thr308
T7247	2395-2398	Protein	denotes	Akt
T7246	5623-5656	Protein	denotes	dependent on RIP1 kinase activity
T7245	2836-2850	Entity	denotes	of Akt, Ser473
T7244	4761-4768	Protein	denotes	of bFGF
T7243	6215-6218	Protein	denotes	JNK
T7242	5939-5945	Entity	denotes	Ser473
T7241	3015-3018	Protein	denotes	Akt
T7240	2658-2661	Protein	denotes	Akt
T7239	600-625	Protein	denotes	growth-factor insensitive
T7238	211-224	Protein	denotes	MAPK pathways
T7237	2968-2973	Protein	denotes	c-Jun
T7236	6087-6097	Entity	denotes	Akt Thr308
T7235	4382-4385	Protein	denotes	JNK
T7234	490-494	Protein	denotes	bFGF
T7233	1943-1960	Protein	denotes	Akt isoforms Akt1
T7232	3984-4023	Protein	denotes	c-Jun following necroptotic stimulation
T7231	4297-4311	Protein	denotes	RIP1 dependent
T7230	4917-4920	Protein	denotes	JNK
T7229	4876-4882	Entity	denotes	Ser473
T7228	2215-2218	Protein	denotes	Akt
T7227	5579-5582	Protein	denotes	Akt
T7226	703-721	Entity	denotes	inhibitor SP600125
T7225	311-314	Protein	denotes	Fig
T7224	845-863	Protein	denotes	of two other MAPKs
T7223	3909-3913	Protein	denotes	TNFα
T7222	5917-5934	Entity	denotes	of the Akt Thr308
T7221	642-659	Protein	denotes	by TNFα (Fig. 2A)
T7220	1813-1816	Entity	denotes	TCN
T7219	4255-4258	Protein	denotes	JNK
T7218	3023-3026	Protein	denotes	JNK
T7217	1993-1998	Entity	denotes	cells
T7216	3821-3824	Protein	denotes	JNK
T7215	2051-2054	Protein	denotes	Fig
T7214	2437-2445	Entity	denotes	zVAD.fmk
T7213	4196-4199	Protein	denotes	Akt
T7212	5796-5800	Protein	denotes	Akt,
T7211	2620-2624	Protein	denotes	TNFα
T7210	3636-3662	Protein	denotes	The RIP1 kinase inhibitor,
T7209	4240-4274	Protein	denotes	Akt Thr308 and JNK phosphorylation
T7208	4798-4806	Entity	denotes	zVAD.fmk
T7207	394-417	Protein	denotes	growth factor-sensitive
T7206	6115-6118	Protein	denotes	Fig
T7205	6087-6090	Protein	denotes	Akt
T7204	33-39	Protein	denotes	of Akt
T7203	585-594	Entity	denotes	the cells
T7202	1860-1866	Protein	denotes	of Akt
T7200	1773-1782	Entity	denotes	inhibitor
T7199	3636-3662	Entity	denotes	The RIP1 kinase inhibitor,
T7198	2608-2616	Entity	denotes	zVAD.fmk
T7197	2712-2718	Entity	denotes	Thr308
T7196	2916-2919	Protein	denotes	p46
T7195	2136-2146	Protein	denotes	Akt3 siRNA
T7194	229-232	Protein	denotes	Akt
T7193	2952-2967	Entity	denotes	major substrate
T7192	5636-5640	Protein	denotes	RIP1
T7191	971-979	Entity	denotes	zVAD.fmk
T7190	2326-2329	Protein	denotes	Akt
T7189	4370-4373	Protein	denotes	Akt
T7188	4902-4905	Protein	denotes	Akt
T7187	873-941	Protein	denotes	ERK, previously reported not to be activated during necroptosis [14]
T7186	1800-1817	Entity	denotes	triciribine (TCN)
T7184	1837-1845	Entity	denotes	membrane
T7183	695-702	Protein	denotes	the JNK
T7182	438-454	Entity	denotes	by zVAD.fmk [16]
T7181	2940-2943	Protein	denotes	JNK
T7180	1705-1734	Entity	denotes	two additional Akt inhibitors
T7179	2839-2843	Protein	denotes	Akt,
T7178	2924-2927	Protein	denotes	p54
T7177	1664-1670	Protein	denotes	of Akt
T7176	2075-2082	Protein	denotes	of Akt3
T7175	3707-3713	Entity	denotes	Thr308
T7174	5587-5590	Protein	denotes	JNK
T7173	3976-3979	Protein	denotes	JNK
T7172	4925-4945	Protein	denotes	c-Jun at 15 minutes,
T7171	5801-5810	Protein	denotes	while IGF
T7170	3856-3864	Entity	denotes	zVAD.fmk
T7169	73-135	Entity	denotes	our observation that growth factors are important for zVAD.fmk
T7168	6344-6355	Protein	denotes	RIP1 kinase
T7167	6344-6348	Protein	denotes	RIP1
T7166	2565-2569	Protein	denotes	S3A,
T7165	2403-2406	Protein	denotes	JNK
T7164	6060-6074	Protein	denotes	RIP1-dependent
T7163	6256-6263	Entity	denotes	of cell
T7162	2334-2337	Protein	denotes	JNK
T7161	1745-1795	Protein	denotes	specific, allosteric kinase inhibitor MK-2206 [25]
T7160	2975-2978	Protein	denotes	Fig
T7159	3636-3662	Protein	denotes	The RIP1 kinase inhibitor,
T7158	2032-2040	Entity	denotes	zVAD.fmk
T7157	4390-4393	Protein	denotes	Jun
T7156	3707-3717	Protein	denotes	Thr308 Akt
T7155	703-712	Entity	denotes	inhibitor
T7154	4133-4138	Protein	denotes	Nec-1
T7153	2426-2431	Protein	denotes	9 hrs
T7152	4420-4428	Entity	denotes	zVAD.fmk
T7151	732-741	Entity	denotes	the cells
T7150	1943-1946	Protein	denotes	Akt
T7149	6207-6210	Protein	denotes	Akt
T7148	4593-4604	Protein	denotes	RIP1 kinase
T7147	4367-4381	Entity	denotes	of Akt Thr308,
R4700	T7147	T7189	partOf	"of Akt Thr308,",Akt
R4701	T7147	T7308	siteOf	"of Akt Thr308,","the phosphorylation of Akt Thr308, JNK and Jun are late"
R4704	T7156	T7303	themeOf	Thr308 Akt,in Thr308 Akt phosphorylation
R4706	T7162	T7306	themeOf	JNK,the activation of Akt and JNK
R4707	T7164	T7295	causeOf	RIP1-dependent,a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation
R4709	T7165	T7287	themeOf	JNK,JNK phosphorylation
R4714	T7174	T7285	themeOf	JNK,the delayed activation of Akt and JNK
R4719	T7175	T7156	partOf	Thr308,Thr308 Akt
R4720	T7175	T7303	siteOf	Thr308,in Thr308 Akt phosphorylation
R4721	T7176	T7279	themeOf	of Akt3,No expression of Akt3 was seen in L929 cells (Fig. S2C)
R4727	T7189	T7308	themeOf	Akt,"the phosphorylation of Akt Thr308, JNK and Jun are late"
R4728	T7190	T7305	themeOf	Akt,the activation of Akt and JNK
R4732	T7204	T7294	themeOf	of Akt,Activation of Akt
R4733	T7205	T7288	themeOf	Akt,in Akt Thr308 phosphorylation
R4738	T7216	T7292	themeOf	JNK,of JNK phosphorylation
R4740	T7218	T7297	themeOf	JNK,These data indicate that both Akt and JNK are activated under necroptotic conditions
R4741	T7219	T7296	themeOf	JNK,JNK phosphorylation
R4743	T7224	T7282	themeOf	of two other MAPKs,inhibition of two other MAPKs
R4746	T7227	T7284	themeOf	Akt,the delayed activation of Akt and JNK
R4749	T7236	T7205	partOf	Akt Thr308,Akt
R4750	T7236	T7288	siteOf	Akt Thr308,in Akt Thr308 phosphorylation
R4753	T7240	T7286	themeOf	Akt,in Akt phosphorylation
R4754	T7241	T7298	themeOf	Akt,These data indicate that both Akt and JNK are activated under necroptotic conditions
R4755	T7243	T7309	themeOf	JNK,"JNK phosphorylation,"
R4759	T7253	T7307	causeOf	Nec-1,"Nec-1, completely prevented the increase in Thr308 Akt phosphorylation,"
R4760	T7254	T7304	themeOf	of Akt,necroptotic regulation of Akt
R4763	T7265	T7302	themeOf	receptor,activated following growth factor receptor activation
R4766	T7268	T7293	themeOf	of Akt,Inhibition of Akt (Akt inhibitor VIII)
R4768	T7271	T7291	themeOf	of Akt,Inhibition of Akt
R4770	T7280	T7290	themeOf	"a delayed increase in Thr308 phosphorylation on Akt,","a delayed increase in Thr308 phosphorylation on Akt,"
R4771	T7276	T7281	themeOf	TNFα,TNFα stimulation
R4772	T7284	T7277	themeOf	the delayed activation of Akt and JNK,the delayed activation of Akt and JNK
R4773	T7285	T7278	themeOf	the delayed activation of Akt and JNK,the delayed activation of Akt and JNK
R4774	T7286	T7299	themeOf	in Akt phosphorylation,Following stimulation with either zVAD.fmk or TNFα we observed a robust increase in Akt phosphorylation
R4775	T7288	T7300	themeOf	in Akt Thr308 phosphorylation,which also showed a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation
R4776	T7300	T7283	themeOf	which also showed a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation,a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation
R4777	T7300	T7295	themeOf	which also showed a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation,a robust delayed necroptosis-specific RIP1-dependent increase in Akt Thr308 phosphorylation
R4778	T7301	T7307	themeOf	"the increase in Thr308 Akt phosphorylation,","Nec-1, completely prevented the increase in Thr308 Akt phosphorylation,"
R4779	T7303	T7301	themeOf	in Thr308 Akt phosphorylation,"the increase in Thr308 Akt phosphorylation,"
R20359	T29355	T29370	themeOf	Akt,Akt expression levels
R20582	T29705	T29719	themeOf	JNK,RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
R20583	T29706	T29720	themeOf	Akt,RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
R20584	T29707	T29719	causeOf	RIP1,RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
R20585	T29707	T29720	causeOf	RIP1,RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
R20586	T29709	T29717	causeOf	kinase-dependent,RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
R20587	T29709	T29718	causeOf	kinase-dependent,RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
R20588	T29719	T29717	themeOf	RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis,RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis
R20589	T29720	T29718	themeOf	RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis,RIP1 kinase-dependent phosphorylation of Akt and JNK during necroptosis

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T29641	3634-3635	.	denotes	.
T29640	3624-3634	NNS	denotes	antibodies
T29639	3614-3623	VBN	denotes	indicated
T29638	3610-3613	DT	denotes	the
T29637	3605-3609	IN	denotes	with
T29636	3600-3604	NN	denotes	blot
T29635	3592-3599	JJ	denotes	western
T29634	3589-3591	IN	denotes	by
T29633	3580-3588	VBN	denotes	followed
T29632	3577-3579	NN	denotes	hr
T29631	3575-3576	CD	denotes	9
T29531	3572-3574	CC	denotes	or
T29530	3568-3571	NN	denotes	min
T29529	3565-3567	CD	denotes	15
T29528	3561-3564	IN	denotes	for
T29527	3559-3560	-RRB-	denotes	)
T29526	3549-3559	NNS	denotes	conditions
T29525	3544-3548	JJ	denotes	free
T29524	3538-3543	NN	denotes	serum
T29523	3537-3538	-LRB-	denotes	(
T29522	3527-3536	NNP	denotes	bFGF/zVAD
T29521	3524-3526	CC	denotes	or
T29520	3519-3523	NNP	denotes	bFGF
T29519	3514-3518	IN	denotes	with
T29518	3503-3513	VBN	denotes	stimulated
T29517	3497-3502	NNS	denotes	cells
T29516	3493-3496	DT	denotes	the
T29515	3490-3492	TO	denotes	to
T29514	3484-3489	VBN	denotes	added
T29513	3480-3483	VBD	denotes	was
T29512	3474-3479	NN	denotes	Nec-1
T29511	3472-3473	-RRB-	denotes	)
T29510	3471-3472	NNP	denotes	D
T29509	3470-3471	-LRB-	denotes	(
T29508	3468-3469	.	denotes	.
T29507	3464-3468	NN	denotes	blot
T29506	3456-3463	JJ	denotes	western
T29505	3452-3455	IN	denotes	for
T29504	3445-3451	NNS	denotes	points
T29503	3440-3444	NN	denotes	time
T29502	3430-3439	JJ	denotes	indicated
T29501	3426-3429	DT	denotes	the
T29500	3423-3425	IN	denotes	at
T29499	3413-3422	VBN	denotes	collected
T29498	3408-3412	VBD	denotes	were
T29497	3400-3407	NNS	denotes	samples
T29496	3396-3399	CC	denotes	and
T29495	3394-3395	-RRB-	denotes	)
T29494	3393-3394	NNP	denotes	C
T29493	3391-3392	,	denotes	,
T29492	3381-3391	NNS	denotes	conditions
T29491	3376-3380	JJ	denotes	free
T29490	3370-3375	NN	denotes	serum
T29489	3369-3370	-LRB-	denotes	(
T29488	3365-3368	NN	denotes	fmk
T29487	3364-3365	.	denotes	.
T29486	3355-3364	NNP	denotes	bFGF/zVAD
T29485	3352-3354	CC	denotes	or
T29484	3350-3351	-RRB-	denotes	)
T29483	3349-3350	NNP	denotes	B
T29482	3348-3349	-LRB-	denotes	(
T29481	3339-3347	NNP	denotes	zVAD.fmk
T29480	3334-3338	IN	denotes	with
T29479	3326-3333	VBN	denotes	treated
T29478	3321-3325	VBD	denotes	were
T29477	3315-3320	NNS	denotes	cells
T29476	3310-3314	NNP	denotes	L929
T29475	3308-3309	-RRB-	denotes	)
T29474	3307-3308	NNP	denotes	C
T29473	3306-3307	,	denotes	,
T29472	3305-3306	NNP	denotes	B
T29471	3304-3305	-LRB-	denotes	(
T29470	3302-3303	.	denotes	.
T29469	3292-3302	NNS	denotes	antibodies
T29468	3282-3291	JJ	denotes	indicated
T29467	3277-3281	IN	denotes	with
T29466	3268-3276	VBG	denotes	blotting
T29465	3260-3267	JJ	denotes	western
T29464	3257-3259	IN	denotes	by
T29463	3248-3256	VBN	denotes	followed
T29462	3246-3247	,	denotes	,
T29461	3244-3246	NN	denotes	hr
T29460	3242-3243	CD	denotes	9
T29459	3238-3241	IN	denotes	for
T29458	3233-3237	NNP	denotes	TNFα
T29457	3230-3232	CC	denotes	or
T29456	3221-3229	NNP	denotes	zVAD.fmk
T29455	3216-3220	IN	denotes	with
T29454	3208-3215	VBN	denotes	treated
T29453	3203-3207	VBD	denotes	were
T29452	3197-3202	NNS	denotes	cells
T29451	3192-3196	NNP	denotes	L929
T29450	3190-3191	-RRB-	denotes	)
T29449	3189-3190	NNP	denotes	A
T29306	1604-1605	.	denotes	.
T29305	1597-1604	VBN	denotes	plotted
T29304	1593-1596	VBD	denotes	was
T29303	1590-1592	NNP	denotes	SD
T29302	1589-1590	NN	denotes	±
T29301	1582-1589	JJ	denotes	average
T29300	1580-1581	,	denotes	,
T29299	1574-1580	NNS	denotes	graphs
T29298	1570-1573	DT	denotes	all
T29297	1567-1569	IN	denotes	In
T29296	1565-1566	.	denotes	.
T29295	1562-1565	NNS	denotes	hrs
T29294	1559-1561	CD	denotes	24
T29293	1553-1558	IN	denotes	after
T29292	1542-1552	VBN	denotes	determined
T29291	1537-1541	VBD	denotes	were
T29290	1530-1536	NNS	denotes	levels
T29289	1519-1529	NN	denotes	expression
T29288	1515-1518	NNP	denotes	Akt
T29287	1511-1514	CC	denotes	and
T29286	1501-1510	NN	denotes	viability
T29285	1496-1500	NNP	denotes	Cell
T29284	1494-1495	.	denotes	.
T29283	1491-1494	NNS	denotes	hrs
T29282	1489-1490	CD	denotes	9
T29281	1485-1488	IN	denotes	for
T29280	1480-1484	NNP	denotes	TNFα
T29279	1477-1479	CC	denotes	or
T29278	1468-1476	NNP	denotes	zVAD.fmk
T29277	1463-1467	IN	denotes	with
T29276	1455-1462	VBN	denotes	treated
T29275	1450-1454	VBD	denotes	were
T29274	1446-1449	NNS	denotes	hrs
T29273	1443-1445	CD	denotes	72
T29272	1439-1442	IN	denotes	for
T29271	1432-1438	NNPS	denotes	siRNAs
T29270	1427-1431	NNP	denotes	Akt3
T29269	1423-1426	CC	denotes	and
T29268	1421-1422	,	denotes	,
T29267	1417-1421	NNP	denotes	Akt2
T29266	1415-1416	,	denotes	,
T29265	1411-1415	NNP	denotes	Akt1
T29264	1406-1410	IN	denotes	with
T29263	1394-1405	VBN	denotes	transfected
T29262	1388-1393	NNS	denotes	cells
T29261	1383-1387	CD	denotes	L929
T29260	1381-1382	-RRB-	denotes	)
T29259	1380-1381	$	denotes	C
T29258	1379-1380	-LRB-	denotes	(
T29257	1377-1378	.	denotes	.
T29256	1374-1377	NNS	denotes	hrs
T29255	1371-1373	CD	denotes	24
T29254	1365-1370	IN	denotes	after
T29253	1354-1364	VBN	denotes	determined
T29252	1350-1353	VBD	denotes	was
T29251	1340-1349	NN	denotes	viability
T29250	1335-1339	NNP	denotes	Cell
T29249	1333-1334	.	denotes	.
T29248	1332-1333	-RRB-	denotes	)
T29247	1327-1332	NNP	denotes	UO126
T29246	1326-1327	-LRB-	denotes	(
T29245	1322-1325	NNP	denotes	Erk
T29244	1318-1321	CC	denotes	and
T29243	1316-1317	,	denotes	,
T29242	1315-1316	-RRB-	denotes	)
T29241	1307-1315	NNP	denotes	PD169316
T29240	1306-1307	-LRB-	denotes	(
T29239	1302-1305	JJ	denotes	p38
T29238	1300-1301	,	denotes	,
T29237	1299-1300	-RRB-	denotes	)
T29236	1291-1299	NNP	denotes	SP600125
T29235	1290-1291	-LRB-	denotes	(
T29234	1286-1289	NNP	denotes	JNK
T29233	1284-1285	,	denotes	,
T29232	1283-1284	-RRB-	denotes	)
T29231	1279-1283	NNP	denotes	VIII
T29230	1269-1278	NN	denotes	inhibitor
T29229	1265-1268	NNP	denotes	Akt
T29228	1264-1265	-LRB-	denotes	(
T29227	1260-1263	NNP	denotes	Akt
T29226	1257-1259	IN	denotes	of
T29225	1246-1256	NNS	denotes	inhibitors
T29224	1243-1245	IN	denotes	of
T29223	1234-1242	NN	denotes	presence
T29222	1230-1233	DT	denotes	the
T29221	1227-1229	IN	denotes	in
T29220	1225-1226	-RRB-	denotes	)
T29219	1224-1225	NNP	denotes	B
T29218	1222-1223	,	denotes	,
T29217	1218-1222	JJ	denotes	free
T29216	1212-1217	NN	denotes	serum
T29215	1211-1212	-LRB-	denotes	(
T29214	1207-1210	NN	denotes	fmk
T29213	1206-1207	.	denotes	.
T29212	1194-1206	NNP	denotes	factors/zVAD
T29211	1187-1193	NN	denotes	growth
T29210	1184-1186	CC	denotes	or
T29209	1182-1183	-RRB-	denotes	)
T29208	1181-1182	NNP	denotes	A
T29207	1179-1180	,	denotes	,
T29206	1174-1179	NN	denotes	serum
T29205	1169-1173	JJ	denotes	full
T29204	1168-1169	-LRB-	denotes	(
T29203	1163-1167	NNP	denotes	TNFα
T29202	1160-1162	CC	denotes	or
T29201	1151-1159	NNP	denotes	zVAD.fmk
T29200	1148-1150	IN	denotes	by
T29199	1140-1147	VBN	denotes	induced
T29198	1136-1139	VBD	denotes	was
T29197	1124-1135	NNP	denotes	Necroptosis
T29196	1122-1123	-RRB-	denotes	)
T29195	1121-1122	NNP	denotes	B
T29194	1120-1121	,	denotes	,
T29193	1119-1120	DT	denotes	A
T29192	1118-1119	-LRB-	denotes	(
T29191	1116-1117	.	denotes	.
T29190	1112-1116	NNP	denotes	TNFα
T29189	1108-1111	CC	denotes	and
T29188	1099-1107	NNP	denotes	zVAD.fmk
T29187	1096-1098	IN	denotes	by
T29186	1088-1095	VBN	denotes	induced
T29185	1076-1087	NN	denotes	necroptosis
T29184	1073-1075	TO	denotes	to
T29183	1061-1072	VBZ	denotes	contributes
T29448	3188-3189	-LRB-	denotes	(
T29447	3186-3187	.	denotes	.
T29446	3175-3186	NN	denotes	necroptosis
T29445	3168-3174	IN	denotes	during
T29444	3164-3167	NNP	denotes	JNK
T29443	3160-3163	CC	denotes	and
T29442	3156-3159	NNP	denotes	Akt
T29441	3153-3155	IN	denotes	of
T29440	3137-3152	NN	denotes	phosphorylation
T29439	3120-3136	JJ	denotes	kinase-dependent
T29438	3115-3119	CD	denotes	RIP1
T29182	1057-1060	NNP	denotes	Akt
R20213	T29182	T29183	nsubj	Akt,contributes
R20214	T29183	T29183	ROOT	contributes,contributes
R20215	T29184	T29183	prep	to,contributes
R20216	T29185	T29184	pobj	necroptosis,to
R20217	T29186	T29185	acl	induced,necroptosis
R20218	T29187	T29186	agent	by,induced
R20219	T29188	T29187	pobj	zVAD.fmk,by
R20220	T29189	T29188	cc	and,zVAD.fmk
R20221	T29190	T29188	conj	TNFα,zVAD.fmk
R20222	T29191	T29183	punct	.,contributes
R20223	T29192	T29199	punct	(,induced
R20224	T29193	T29199	intj	A,induced
R20225	T29194	T29199	punct	",",induced
R20226	T29195	T29197	nmod	B,Necroptosis
R20227	T29196	T29197	punct	),Necroptosis
R20228	T29197	T29199	nsubjpass	Necroptosis,induced
R20229	T29198	T29199	auxpass	was,induced
R20230	T29199	T29199	ROOT	induced,induced
R20231	T29200	T29199	agent	by,induced
R20232	T29201	T29200	pobj	zVAD.fmk,by
R20233	T29202	T29201	cc	or,zVAD.fmk
R20234	T29203	T29201	conj	TNFα,zVAD.fmk
R20235	T29204	T29203	punct	(,TNFα
R20236	T29205	T29206	amod	full,serum
R20237	T29206	T29203	appos	serum,TNFα
R20238	T29207	T29203	punct	",",TNFα
R20239	T29208	T29203	conj	A,TNFα
R20240	T29209	T29208	punct	),A
R20241	T29210	T29199	cc	or,induced
R20242	T29211	T29199	conj	growth,induced
R20243	T29212	T29211	appos	factors/zVAD,growth
R20244	T29213	T29199	punct	.,induced
R20245	T29214	T29214	ROOT	fmk,fmk
R20246	T29215	T29219	punct	(,B
R20247	T29216	T29217	npadvmod	serum,free
R20248	T29217	T29219	amod	free,B
R20249	T29218	T29219	punct	",",B
R20250	T29219	T29214	appos	B,fmk
R20251	T29220	T29219	punct	),B
R20252	T29221	T29214	prep	in,fmk
R20253	T29222	T29223	det	the,presence
R20254	T29223	T29221	pobj	presence,in
R20255	T29224	T29223	prep	of,presence
R20256	T29225	T29224	pobj	inhibitors,of
R20257	T29226	T29225	prep	of,inhibitors
R20258	T29227	T29226	pobj	Akt,of
R20259	T29228	T29231	punct	(,VIII
R20260	T29229	T29231	compound	Akt,VIII
R20261	T29230	T29231	compound	inhibitor,VIII
R20262	T29231	T29227	appos	VIII,Akt
R20263	T29232	T29227	punct	),Akt
R20264	T29233	T29227	punct	",",Akt
R20265	T29234	T29227	conj	JNK,Akt
R20266	T29235	T29236	punct	(,SP600125
R20267	T29236	T29234	appos	SP600125,JNK
R20268	T29237	T29234	punct	),JNK
R20269	T29238	T29214	punct	",",fmk
R20270	T29239	T29214	amod	p38,fmk
R20271	T29240	T29241	punct	(,PD169316
R20272	T29241	T29239	appos	PD169316,p38
R20273	T29242	T29241	punct	),PD169316
R20274	T29243	T29239	punct	",",p38
R20275	T29244	T29239	cc	and,p38
R20276	T29245	T29239	conj	Erk,p38
R20277	T29246	T29247	punct	(,UO126
R20278	T29247	T29245	appos	UO126,Erk
R20279	T29248	T29245	punct	),Erk
R20280	T29249	T29214	punct	.,fmk
R20281	T29250	T29251	compound	Cell,viability
R20282	T29251	T29253	nsubjpass	viability,determined
R20283	T29252	T29253	auxpass	was,determined
R20284	T29253	T29253	ROOT	determined,determined
R20285	T29254	T29253	prep	after,determined
R20286	T29255	T29256	nummod	24,hrs
R20287	T29256	T29254	pobj	hrs,after
R20288	T29257	T29253	punct	.,determined
R20289	T29258	T29259	punct	(,C
R20290	T29259	T29262	nmod	C,cells
R20291	T29260	T29259	punct	),C
R20292	T29261	T29262	nummod	L929,cells
R20293	T29262	T29276	nsubjpass	cells,treated
R20294	T29263	T29262	acl	transfected,cells
R20295	T29264	T29263	prep	with,transfected
R20296	T29265	T29264	pobj	Akt1,with
R20297	T29266	T29265	punct	",",Akt1
R20298	T29267	T29265	conj	Akt2,Akt1
R20299	T29268	T29267	punct	",",Akt2
R20300	T29269	T29267	cc	and,Akt2
R20301	T29270	T29267	conj	Akt3,Akt2
R20302	T29271	T29265	appos	siRNAs,Akt1
R20303	T29272	T29263	prep	for,transfected
R20304	T29273	T29274	nummod	72,hrs
R20305	T29274	T29272	pobj	hrs,for
R20306	T29275	T29276	auxpass	were,treated
R20307	T29276	T29276	ROOT	treated,treated
R20308	T29277	T29276	prep	with,treated
R20309	T29278	T29277	pobj	zVAD.fmk,with
R20310	T29279	T29278	cc	or,zVAD.fmk
R20311	T29280	T29278	conj	TNFα,zVAD.fmk
R20312	T29281	T29276	prep	for,treated
R20313	T29282	T29283	nummod	9,hrs
R20314	T29283	T29281	pobj	hrs,for
R20315	T29284	T29276	punct	.,treated
R20316	T29285	T29286	compound	Cell,viability
R20317	T29286	T29292	nsubjpass	viability,determined
R20318	T29287	T29286	cc	and,viability
R20319	T29288	T29290	compound	Akt,levels
R20320	T29289	T29290	compound	expression,levels
R20321	T29290	T29286	conj	levels,viability
R20322	T29291	T29292	auxpass	were,determined
R20323	T29292	T29292	ROOT	determined,determined
R20324	T29293	T29292	prep	after,determined
R20325	T29294	T29295	nummod	24,hrs
R20326	T29295	T29293	pobj	hrs,after
R20327	T29296	T29292	punct	.,determined
R20328	T29297	T29305	prep	In,plotted
R20329	T29298	T29299	det	all,graphs
R20330	T29299	T29297	pobj	graphs,In
R20331	T29300	T29305	punct	",",plotted
R20332	T29301	T29302	amod	average,±
R20333	T29302	T29303	compound	±,SD
R20334	T29303	T29305	nsubjpass	SD,plotted
R20335	T29304	T29305	auxpass	was,plotted
R20336	T29305	T29305	ROOT	plotted,plotted
R20337	T29306	T29305	punct	.,plotted
R20361	T29438	T29440	nummod	RIP1,phosphorylation
R20362	T29439	T29440	amod	kinase-dependent,phosphorylation
R20363	T29440	T29440	ROOT	phosphorylation,phosphorylation
R20364	T29441	T29440	prep	of,phosphorylation
R20365	T29442	T29441	pobj	Akt,of
R20366	T29443	T29442	cc	and,Akt
R20367	T29444	T29442	conj	JNK,Akt
R20368	T29445	T29440	prep	during,phosphorylation
R20369	T29446	T29445	pobj	necroptosis,during
R20370	T29447	T29440	punct	.,phosphorylation
R20371	T29448	T29454	punct	(,treated
R20372	T29449	T29452	nmod	A,cells
R20373	T29450	T29449	punct	),A
R20374	T29451	T29452	compound	L929,cells
R20375	T29452	T29454	nsubjpass	cells,treated
R20376	T29453	T29454	auxpass	were,treated
R20377	T29454	T29454	ROOT	treated,treated
R20378	T29455	T29454	prep	with,treated
R20379	T29456	T29455	pobj	zVAD.fmk,with
R20380	T29457	T29456	cc	or,zVAD.fmk
R20381	T29458	T29456	conj	TNFα,zVAD.fmk
R20382	T29459	T29454	prep	for,treated
R20383	T29460	T29461	nummod	9,hr
R20384	T29461	T29459	pobj	hr,for
R20385	T29462	T29454	punct	",",treated
R20386	T29463	T29454	advcl	followed,treated
R20387	T29464	T29463	agent	by,followed
R20388	T29465	T29466	amod	western,blotting
R20389	T29466	T29464	pobj	blotting,by
R20390	T29467	T29466	prep	with,blotting
R20391	T29468	T29469	amod	indicated,antibodies
R20392	T29469	T29467	pobj	antibodies,with
R20393	T29470	T29454	punct	.,treated
R20394	T29471	T29474	punct	(,C
R20395	T29472	T29474	nmod	B,C
R20396	T29473	T29474	punct	",",C
R20397	T29474	T29474	ROOT	C,C
R20398	T29475	T29474	punct	),C
R20399	T29476	T29477	compound	L929,cells
R20400	T29477	T29479	nsubjpass	cells,treated
R20401	T29478	T29479	auxpass	were,treated
R20402	T29479	T29479	ROOT	treated,treated
R20403	T29480	T29479	prep	with,treated
R20404	T29481	T29480	pobj	zVAD.fmk,with
R20405	T29482	T29483	punct	(,B
R20406	T29483	T29481	appos	B,zVAD.fmk
R20407	T29484	T29481	punct	),zVAD.fmk
R20408	T29485	T29481	cc	or,zVAD.fmk
R20409	T29486	T29481	conj	bFGF/zVAD,zVAD.fmk
R20410	T29487	T29479	punct	.,treated
R20411	T29488	T29492	amod	fmk,conditions
R20412	T29489	T29492	punct	(,conditions
R20413	T29490	T29492	nmod	serum,conditions
R20414	T29491	T29492	amod	free,conditions
R20415	T29492	T29499	nsubjpass	conditions,collected
R20416	T29493	T29492	punct	",",conditions
R20417	T29494	T29492	appos	C,conditions
R20418	T29495	T29494	punct	),C
R20419	T29496	T29492	cc	and,conditions
R20420	T29497	T29492	conj	samples,conditions
R20421	T29498	T29499	auxpass	were,collected
R20422	T29499	T29499	ROOT	collected,collected
R20423	T29500	T29499	prep	at,collected
R20424	T29501	T29503	det	the,time
R20425	T29502	T29503	amod	indicated,time
R20426	T29503	T29500	pobj	time,at
R20427	T29504	T29500	pobj	points,at
R20428	T29505	T29504	prep	for,points
R20429	T29506	T29507	amod	western,blot
R20430	T29507	T29505	pobj	blot,for
R20431	T29508	T29499	punct	.,collected
R20432	T29509	T29514	punct	(,added
R20433	T29510	T29512	amod	D,Nec-1
R20434	T29511	T29512	punct	),Nec-1
R20435	T29512	T29514	nsubjpass	Nec-1,added
R20436	T29513	T29514	auxpass	was,added
R20437	T29514	T29514	ROOT	added,added
R20438	T29515	T29514	prep	to,added
R20439	T29516	T29517	det	the,cells
R20440	T29517	T29515	pobj	cells,to
R20441	T29518	T29517	acl	stimulated,cells
R20442	T29519	T29518	prep	with,stimulated
R20443	T29520	T29519	pobj	bFGF,with
R20444	T29521	T29520	cc	or,bFGF
R20445	T29522	T29520	conj	bFGF/zVAD,bFGF
R20446	T29523	T29526	punct	(,conditions
R20447	T29524	T29526	nmod	serum,conditions
R20448	T29525	T29526	amod	free,conditions
R20449	T29526	T29522	parataxis	conditions,bFGF/zVAD
R20450	T29527	T29526	punct	),conditions
R20451	T29528	T29518	prep	for,stimulated
R20452	T29529	T29632	nummod	15,hr
R20453	T29530	T29632	nmod	min,hr
R20454	T29531	T29530	cc	or,min
R20551	T29631	T29530	nummod	9,min
R20552	T29632	T29528	pobj	hr,for
R20553	T29633	T29632	acl	followed,hr
R20554	T29634	T29633	agent	by,followed
R20555	T29635	T29636	amod	western,blot
R20556	T29636	T29634	pobj	blot,by
R20557	T29637	T29636	prep	with,blot
R20558	T29638	T29640	det	the,antibodies
R20559	T29639	T29640	amod	indicated,antibodies
R20560	T29640	T29637	pobj	antibodies,with
R20561	T29641	T29514	punct	.,added

bionlp-st-ge-2016-test-tees

Id	Subject	Object	Predicate	Lexical cue
T29689	3527-3536	Protein	denotes	bFGF/zVAD
T29688	3519-3523	Protein	denotes	bFGF
T29687	3355-3368	Protein	denotes	bFGF/zVAD.fmk
T29686	3233-3237	Protein	denotes	TNFα
T29685	3221-3229	Protein	denotes	zVAD.fmk
T29684	3127-3136	Positive_regulation	denotes	dependent
T29683	3127-3136	Positive_regulation	denotes	dependent
T29682	3137-3152	Phosphorylation	denotes	phosphorylation
T29681	3137-3152	Phosphorylation	denotes	phosphorylation
T29680	3164-3167	Protein	denotes	JNK
T29679	3156-3159	Protein	denotes	Akt
T29678	3115-3126	Protein	denotes	RIP1 kinase
T29181	1519-1529	Gene_expression	denotes	expression
T29180	1515-1518	Protein	denotes	Akt
T29179	1394-1405	Positive_regulation	denotes	transfected
T29178	1394-1405	Positive_regulation	denotes	transfected
T29177	1394-1405	Positive_regulation	denotes	transfected
T29176	1394-1405	Gene_expression	denotes	transfected
T29175	1394-1405	Gene_expression	denotes	transfected
T29174	1394-1405	Gene_expression	denotes	transfected
T29173	1468-1484	Protein	denotes	zVAD.fmk or TNFα
T29172	1427-1438	Protein	denotes	Akt3 siRNAs
T29171	1417-1421	Protein	denotes	Akt2
T29170	1411-1415	Protein	denotes	Akt1
T29169	1246-1256	Negative_regulation	denotes	inhibitors
T29168	1246-1256	Negative_regulation	denotes	inhibitors
T29167	1246-1256	Negative_regulation	denotes	inhibitors
T29166	1246-1256	Negative_regulation	denotes	inhibitors
T29165	1269-1278	Negative_regulation	denotes	inhibitor
T29164	1269-1278	Negative_regulation	denotes	inhibitor
T29163	1269-1278	Negative_regulation	denotes	inhibitor
T29162	1269-1278	Negative_regulation	denotes	inhibitor
T29161	1246-1256	Negative_regulation	denotes	inhibitors
T29160	1246-1256	Negative_regulation	denotes	inhibitors
T29159	1246-1256	Negative_regulation	denotes	inhibitors
T29158	1246-1256	Negative_regulation	denotes	inhibitors
T29157	1246-1256	Negative_regulation	denotes	inhibitors
T29156	1246-1256	Negative_regulation	denotes	inhibitors
T29155	1124-1135	Entity	denotes	Necroptosis
T29154	1327-1332	Protein	denotes	UO126
T29153	1322-1325	Protein	denotes	Erk
T29152	1307-1315	Protein	denotes	PD169316
T29151	1302-1305	Protein	denotes	p38
T29150	1286-1289	Protein	denotes	JNK
T29149	1265-1268	Protein	denotes	Akt
T29148	1260-1263	Protein	denotes	Akt
T29147	1151-1167	Protein	denotes	zVAD.fmk or TNFα
T29146	1112-1116	Protein	denotes	TNFα
T29145	1099-1107	Protein	denotes	zVAD.fmk
T29144	1057-1060	Protein	denotes	Akt
T6917	5946-5961	Phosphorylation	denotes	phosphorylation
T6916	6120-6123	Protein	denotes	S3D
T6915	6115-6118	Protein	denotes	Fig
T6914	6087-6090	Protein	denotes	Akt
T6913	6060-6064	Protein	denotes	RIP1
T6912	5924-5934	Protein	denotes	Akt Thr308
T6911	5851-5859	Positive_regulation	denotes	increase
T6910	5851-5859	Positive_regulation	denotes	increase
T6909	5758-5766	Positive_regulation	denotes	increase
T6908	5758-5766	Positive_regulation	denotes	increase
T6907	5863-5878	Phosphorylation	denotes	phosphorylation
T6906	5863-5878	Phosphorylation	denotes	phosphorylation
T6905	5777-5792	Phosphorylation	denotes	phosphorylation
T6904	5885-5888	Protein	denotes	S3C
T6903	5880-5883	Protein	denotes	Fig
T6902	5807-5810	Protein	denotes	IGF
T6901	5796-5799	Protein	denotes	Akt
T6900	5770-5776	Protein	denotes	Thr308
T6899	5673-5677	Protein	denotes	zVAD
T6898	5669-5672	Protein	denotes	IGF
T6897	5480-5487	Negative_regulation	denotes	blocked
T6896	5480-5487	Negative_regulation	denotes	blocked
T6895	5319-5327	Positive_regulation	denotes	increase
T6894	5319-5327	Positive_regulation	denotes	increase
T6893	5319-5327	Positive_regulation	denotes	increase
T6892	5565-5575	Positive_regulation	denotes	activation
T6891	5565-5575	Positive_regulation	denotes	activation
T6890	5502-5510	Positive_regulation	denotes	increase
T6889	5354-5369	Phosphorylation	denotes	phosphorylation
T6888	5354-5369	Phosphorylation	denotes	phosphorylation
T6887	5354-5369	Phosphorylation	denotes	phosphorylation
T6886	5319-5327	Positive_regulation	denotes	increase
T6885	5636-5647	Protein	denotes	RIP1 kinase
T6884	5587-5590	Protein	denotes	JNK
T6850	4917-4920	Protein	denotes	JNK
T6849	4902-4905	Protein	denotes	Akt
T6848	4798-4806	Protein	denotes	zVAD.fmk
T6847	4764-4768	Protein	denotes	bFGF
T6846	4557-4570	Regulation	denotes	contributions
T6845	4620-4630	Regulation	denotes	regulation
T6844	4557-4570	Regulation	denotes	contributions
T6843	4634-4637	Protein	denotes	Akt
T6842	4593-4604	Protein	denotes	RIP1 kinase
T6841	4351-4366	Phosphorylation	denotes	phosphorylation
T6840	4351-4366	Phosphorylation	denotes	phosphorylation
T6839	4351-4366	Phosphorylation	denotes	phosphorylation
T6838	4526-4529	Protein	denotes	S3A
T6837	4521-4524	Protein	denotes	Fig
T6836	4425-4428	Protein	denotes	fmk
T6835	4390-4393	Protein	denotes	Jun
T6834	4382-4385	Protein	denotes	JNK
T6833	4370-4380	Protein	denotes	Akt Thr308
T6832	4302-4311	Positive_regulation	denotes	dependent
T6831	4302-4311	Positive_regulation	denotes	dependent
T6830	4302-4311	Positive_regulation	denotes	dependent
T6829	4302-4311	Positive_regulation	denotes	dependent
T6828	4259-4274	Phosphorylation	denotes	phosphorylation
T6827	4259-4274	Phosphorylation	denotes	phosphorylation
T6826	4297-4301	Protein	denotes	RIP1
T6825	4255-4258	Protein	denotes	JNK
T6824	4240-4250	Protein	denotes	Akt Thr308
T6823	4163-4178	Phosphorylation	denotes	phosphorylation
T6822	4163-4178	Phosphorylation	denotes	phosphorylation
T6821	4163-4178	Phosphorylation	denotes	phosphorylation
T6820	4208-4215	Protein	denotes	Fig. 3A
T6819	4203-4206	Protein	denotes	JNK
T6818	4196-4199	Protein	denotes	Akt
T6817	4133-4138	Protein	denotes	Nec-1
T6816	4113-4118	Protein	denotes	Nec-1
T6815	3941-3948	Regulation	denotes	changes
T6814	3976-3979	Protein	denotes	JNK
T6813	3794-3803	Negative_regulation	denotes	prevented
T6812	3808-3817	Positive_regulation	denotes	induction
T6811	3825-3840	Phosphorylation	denotes	phosphorylation
T6810	3909-3913	Protein	denotes	TNFα
T6809	3821-3824	Protein	denotes	JNK
T6808	3788-3793	Protein	denotes	Nec-1
T6807	3681-3690	Negative_regulation	denotes	prevented
T6806	3695-3703	Positive_regulation	denotes	increase
T6805	3718-3733	Phosphorylation	denotes	phosphorylation
T6804	3771-3774	Protein	denotes	S1D
T6803	3766-3769	Protein	denotes	Fig
T6802	3757-3764	Protein	denotes	Fig. 3A
T6801	3741-3747	Protein	denotes	Nec-1i
T6800	3707-3717	Protein	denotes	Thr308 Akt
T6799	3663-3668	Protein	denotes	Nec-1
T6798	3640-3651	Protein	denotes	RIP1 kinase
T6797	3031-3040	Positive_regulation	denotes	activated
T6796	3031-3040	Positive_regulation	denotes	activated
T6795	3023-3026	Protein	denotes	JNK
T6794	3015-3018	Protein	denotes	Akt
T6793	2872-2880	Positive_regulation	denotes	increase
T6792	2872-2880	Positive_regulation	denotes	increase
T6791	2872-2880	Positive_regulation	denotes	increase
T6790	2888-2903	Phosphorylation	denotes	phosphorylation
T6789	2888-2903	Phosphorylation	denotes	phosphorylation
T6788	2888-2903	Phosphorylation	denotes	phosphorylation
T6787	2940-2943	Protein	denotes	JNK
T6786	2924-2927	Protein	denotes	p54
T6785	2916-2919	Protein	denotes	p46
T6784	2792-2799	Regulation	denotes	changes
T6783	2792-2799	Regulation	denotes	changes
T6782	2776-2791	Phosphorylation	denotes	phosphorylation
T6781	2776-2791	Phosphorylation	denotes	phosphorylation
T6780	2844-2850	Protein	denotes	Ser473
T6779	2839-2842	Protein	denotes	Akt
T6778	2646-2654	Positive_regulation	denotes	increase
T6777	2662-2677	Phosphorylation	denotes	phosphorylation
T6776	2658-2661	Protein	denotes	Akt
T6775	2620-2624	Protein	denotes	TNFα
T6774	2608-2616	Protein	denotes	zVAD.fmk
T6773	2384-2391	Regulation	denotes	changes
T6772	2384-2391	Regulation	denotes	changes
T6771	2384-2391	Regulation	denotes	changes
T6770	2455-2466	Positive_regulation	denotes	stimulation
T6769	2407-2422	Phosphorylation	denotes	phosphorylation
T6768	2407-2422	Phosphorylation	denotes	phosphorylation
T6767	2312-2322	Positive_regulation	denotes	activation
T6766	2312-2322	Positive_regulation	denotes	activation
T6765	2450-2454	Protein	denotes	TNFα
T6764	2403-2406	Protein	denotes	JNK
T6763	2395-2398	Protein	denotes	Akt
T6762	2334-2337	Protein	denotes	JNK
T6761	2326-2329	Protein	denotes	Akt
T6760	2215-2218	Protein	denotes	Akt
T6759	2064-2074	Gene_expression	denotes	expression
T6758	2136-2146	Protein	denotes	Akt3 siRNA
T6757	2078-2082	Protein	denotes	Akt3
T6756	1983-1992	Gene_expression	denotes	protected
T6755	1930-1939	Negative_regulation	denotes	knockdown
T6754	1930-1939	Negative_regulation	denotes	knockdown
T6753	1930-1939	Negative_regulation	denotes	knockdown
T6752	2051-2058	Protein	denotes	Fig. 2C
T6751	2045-2049	Protein	denotes	TNFα
T6750	2032-2040	Protein	denotes	zVAD.fmk
T6749	1965-1969	Protein	denotes	Akt2
T6748	1956-1960	Protein	denotes	Akt1
T6747	1943-1946	Protein	denotes	Akt
T6746	1830-1836	Negative_regulation	denotes	blocks
T6745	1846-1859	Localization	denotes	translocation
T6744	1773-1782	Negative_regulation	denotes	inhibitor
T6743	1724-1734	Negative_regulation	denotes	inhibitors
T6742	1724-1734	Negative_regulation	denotes	inhibitors
T6741	1896-1904	Protein	denotes	Fig. S2B
T6740	1863-1866	Protein	denotes	Akt
T6739	1755-1772	Protein	denotes	allosteric kinase
T6738	1720-1723	Protein	denotes	Akt
T6737	1667-1670	Protein	denotes	Akt
T6736	834-844	Negative_regulation	denotes	inhibition
T6735	834-844	Negative_regulation	denotes	inhibition
T6734	971-987	Protein	denotes	zVAD.fmk or TNFα
T6733	873-876	Protein	denotes	ERK
T6732	865-868	Protein	denotes	p38
T6731	804-807	Protein	denotes	S2A
T6730	799-802	Protein	denotes	Fig
T6729	785-794	Protein	denotes	Fig. 2A,B
T6728	765-769	Protein	denotes	TNFα
T6727	752-760	Protein	denotes	zVAD.fmk
T6726	699-702	Protein	denotes	JNK
T6725	552-562	Negative_regulation	denotes	Inhibition
T6724	651-658	Protein	denotes	Fig. 2A
T6723	645-649	Protein	denotes	TNFα
T6722	566-569	Protein	denotes	Akt
T6721	321-331	Negative_regulation	denotes	Inhibition
T6720	498-512	Protein	denotes	IGF-1/zVAD.fmk
T6719	490-494	Protein	denotes	bFGF
T6718	340-343	Protein	denotes	Akt
T6717	335-338	Protein	denotes	Akt
T6716	299-309	Positive_regulation	denotes	activation
T6715	276-298	Protein	denotes	growth factor receptor
T6714	211-215	Protein	denotes	MAPK
T6713	12-21	Positive_regulation	denotes	dependent
T6712	40-51	Positive_regulation	denotes	Contributes
T6711	22-32	Positive_regulation	denotes	Activation
T6710	36-39	Protein	denotes	Akt
T6883	5579-5582	Protein	denotes	Akt
T6882	5492-5501	Protein	denotes	bFGF/zVAD
T6881	5462-5465	Protein	denotes	S1E
T6880	5457-5460	Protein	denotes	Fig
T6879	5442-5455	Protein	denotes	analog Nec-1i
T6878	5414-5419	Protein	denotes	Nec-1
T6877	5402-5406	Protein	denotes	zVAD
T6876	5397-5401	Protein	denotes	bFGF
T6875	5388-5392	Protein	denotes	bFGF
T6874	5348-5353	Protein	denotes	c-Jun
T6873	5344-5347	Protein	denotes	JNK
T6872	5336-5339	Protein	denotes	Akt
T6871	5274-5279	Protein	denotes	Nec-1
T6870	5213-5221	Positive_regulation	denotes	increase
T6867	5229-5244	Phosphorylation	denotes	phosphorylation
T6866	5229-5244	Phosphorylation	denotes	phosphorylation
T6865	5142-5157	Phosphorylation	denotes	phosphorylation
T6864	5256-5259	Protein	denotes	Jun
T6863	5248-5251	Protein	denotes	JNK
T6862	5188-5191	Protein	denotes	Akt
T6861	5076-5080	Protein	denotes	bFGF
T6860	5053-5066	Protein	denotes	bFGF/zVAD.fmk
T6859	4848-4856	Positive_regulation	denotes	increase
T6858	4848-4856	Positive_regulation	denotes	increase
T6857	4883-4898	Phosphorylation	denotes	phosphorylation
T6856	4883-4898	Phosphorylation	denotes	phosphorylation
T6855	4876-4882	Entity	denotes	Ser473
T6854	4865-4871	Entity	denotes	Thr308
T6853	4848-4856	Positive_regulation	denotes	increase
T6852	4752-4760	Positive_regulation	denotes	addition
T6851	4925-4930	Protein	denotes	c-Jun
T6869	5213-5221	Positive_regulation	denotes	increase
T6868	5126-5134	Positive_regulation	denotes	increase
T6927	6194-6203	Positive_regulation	denotes	increases
T6926	6194-6203	Positive_regulation	denotes	increases
T6925	6219-6234	Phosphorylation	denotes	phosphorylation
T6924	6219-6234	Phosphorylation	denotes	phosphorylation
T6923	6194-6203	Positive_regulation	denotes	increases
T6922	6344-6355	Protein	denotes	RIP1 kinase
T6921	6215-6218	Protein	denotes	JNK
T6920	6207-6210	Protein	denotes	Akt
T6919	6075-6083	Positive_regulation	denotes	increase
T6918	6098-6113	Phosphorylation	denotes	phosphorylation
R4499	T6764	T6769	themeOf	JNK,phosphorylation
R4500	T6765	T6770	themeOf	TNFα,stimulation
R4502	T6768	T6771	themeOf	phosphorylation,changes
R4503	T6710	T6711	themeOf	Akt,Activation
R4504	T6711	T6712	themeOf	Activation,Contributes
R4505	T6711	T6713	themeOf	Activation,dependent
R4506	T6769	T6772	themeOf	phosphorylation,changes
R4507	T6770	T6773	themeOf	stimulation,changes
R4508	T6715	T6716	themeOf	growth factor receptor,activation
R4509	T6717	T6721	themeOf	Akt,Inhibition
R4510	T6776	T6777	themeOf	Akt,phosphorylation
R4511	T6722	T6725	themeOf	Akt,Inhibition
R4512	T6777	T6778	themeOf	phosphorylation,increase
R4513	T6779	T6781	themeOf	Akt,phosphorylation
R4514	T6732	T6735	themeOf	p38,inhibition
R4515	T6733	T6736	themeOf	ERK,inhibition
R4516	T6780	T6782	themeOf	Ser473,phosphorylation
R4517	T6781	T6783	themeOf	phosphorylation,changes
R4518	T6738	T6742	themeOf	Akt,inhibitors
R4519	T6782	T6784	themeOf	phosphorylation,changes
R4520	T6739	T6744	themeOf	allosteric kinase,inhibitor
R4521	T6740	T6745	themeOf	Akt,translocation
R4522	T6741	T6743	themeOf	Fig. S2B,inhibitors
R4523	T6785	T6788	themeOf	p46,phosphorylation
R4524	T6745	T6746	themeOf	translocation,blocks
R4525	T6786	T6789	themeOf	p54,phosphorylation
R4526	T6747	T6753	themeOf	Akt,knockdown
R4527	T6748	T6754	themeOf	Akt1,knockdown
R4528	T6749	T6755	themeOf	Akt2,knockdown
R4529	T6787	T6790	themeOf	JNK,phosphorylation
R4530	T6752	T6756	themeOf	Fig. 2C,protected
R4531	T6788	T6791	themeOf	phosphorylation,increase
R4532	T6789	T6792	themeOf	phosphorylation,increase
R4533	T6757	T6759	themeOf	Akt3,expression
R4534	T6790	T6793	themeOf	phosphorylation,increase
R4535	T6794	T6796	themeOf	Akt,activated
R4536	T6761	T6766	themeOf	Akt,activation
R4537	T6762	T6767	themeOf	JNK,activation
R4538	T6763	T6768	themeOf	Akt,phosphorylation
R4539	T6795	T6797	themeOf	JNK,activated
R4540	T6799	T6807	causeOf	Nec-1,prevented
R4541	T6834	T6840	themeOf	JNK,phosphorylation
R4542	T6800	T6805	themeOf	Thr308 Akt,phosphorylation
R4543	T6835	T6841	themeOf	Jun,phosphorylation
R4544	T6805	T6806	themeOf	phosphorylation,increase
R4545	T6842	T6844	themeOf	RIP1 kinase,contributions
R4546	T6806	T6807	themeOf	increase,prevented
R4547	T6843	T6845	themeOf	Akt,regulation
R4548	T6808	T6813	causeOf	Nec-1,prevented
R4549	T6845	T6846	themeOf	regulation,contributions
R4550	T6847	T6852	themeOf	bFGF,addition
R4551	T6809	T6811	themeOf	JNK,phosphorylation
R4552	T6849	T6856	themeOf	Akt,phosphorylation
R4553	T6849	T6857	themeOf	Akt,phosphorylation
R4554	T6849	T6854	partOf	Akt,Thr308
R4555	T6849	T6855	partOf	Akt,Ser473
R4556	T6850	T6853	themeOf	JNK,increase
R4557	T6811	T6812	themeOf	phosphorylation,induction
R4558	T6812	T6813	themeOf	induction,prevented
R4559	T6814	T6815	themeOf	JNK,changes
R4560	T6854	T6856	Site	Thr308,phosphorylation
R4561	T6855	T6857	Site	Ser473,phosphorylation
R4562	T6856	T6858	themeOf	phosphorylation,increase
R4563	T6857	T6859	themeOf	phosphorylation,increase
R4564	T6817	T6821	themeOf	Nec-1,phosphorylation
R4565	T6862	T6865	themeOf	Akt,phosphorylation
R4566	T6818	T6822	themeOf	Akt,phosphorylation
R4567	T6863	T6866	themeOf	JNK,phosphorylation
R4568	T6864	T6867	themeOf	Jun,phosphorylation
R4569	T6865	T6868	themeOf	phosphorylation,increase
R4570	T6819	T6823	themeOf	JNK,phosphorylation
R4571	T6866	T6869	themeOf	phosphorylation,increase
R4572	T6867	T6870	themeOf	phosphorylation,increase
R4573	T6824	T6827	themeOf	Akt Thr308,phosphorylation
R4574	T6871	T6886	causeOf	Nec-1,increase
R4575	T6871	T6893	causeOf	Nec-1,increase
R4576	T6871	T6894	causeOf	Nec-1,increase
R4577	T6871	T6895	causeOf	Nec-1,increase
R4578	T6872	T6886	themeOf	Akt,increase
R4579	T6872	T6887	themeOf	Akt,phosphorylation
R4580	T6824	T6829	causeOf	Akt Thr308,dependent
R4581	T6873	T6888	themeOf	JNK,phosphorylation
R4582	T6824	T6830	causeOf	Akt Thr308,dependent
R4583	T6825	T6828	themeOf	JNK,phosphorylation
R4584	T6874	T6889	themeOf	c-Jun,phosphorylation
R4585	T6826	T6831	causeOf	RIP1,dependent
R4586	T6878	T6896	causeOf	Nec-1,blocked
R4587	T6826	T6832	causeOf	RIP1,dependent
R4588	T6879	T6897	causeOf	analog Nec-1i,blocked
R4589	T6827	T6829	themeOf	phosphorylation,dependent
R4590	T6882	T6890	themeOf	bFGF/zVAD,increase
R4591	T6827	T6831	themeOf	phosphorylation,dependent
R4592	T6883	T6891	themeOf	Akt,activation
R4593	T6828	T6830	themeOf	phosphorylation,dependent
R4594	T6884	T6892	themeOf	JNK,activation
R4595	T6828	T6832	themeOf	phosphorylation,dependent
R4596	T6833	T6839	themeOf	Akt Thr308,phosphorylation
R4597	T6887	T6893	themeOf	phosphorylation,increase
R4598	T6888	T6894	themeOf	phosphorylation,increase
R4599	T6889	T6895	themeOf	phosphorylation,increase
R4600	T6890	T6896	themeOf	increase,blocked
R4601	T6890	T6897	themeOf	increase,blocked
R20192	T29148	T29156	themeOf	Akt,inhibitors
R20193	T29148	T29162	themeOf	Akt,inhibitor
R20194	T29149	T29163	themeOf	Akt,inhibitor
R20195	T29150	T29157	themeOf	JNK,inhibitors
R20196	T29151	T29158	themeOf	p38,inhibitors
R20197	T29151	T29164	themeOf	p38,inhibitor
R20198	T29152	T29159	themeOf	PD169316,inhibitors
R20199	T29153	T29160	themeOf	Erk,inhibitors
R20200	T29153	T29165	themeOf	Erk,inhibitor
R20201	T29154	T29161	themeOf	UO126,inhibitors
R20202	T29162	T29166	themeOf	inhibitor,inhibitors
R20203	T29163	T29167	themeOf	inhibitor,inhibitors
R20204	T29164	T29168	themeOf	inhibitor,inhibitors
R20205	T29165	T29169	themeOf	inhibitor,inhibitors
R20206	T29170	T29174	themeOf	Akt1,transfected
R20207	T29171	T29175	themeOf	Akt2,transfected
R20208	T29172	T29176	themeOf	Akt3 siRNAs,transfected
R20209	T29174	T29177	themeOf	transfected,transfected
R20210	T29175	T29178	themeOf	transfected,transfected
R20211	T29176	T29179	themeOf	transfected,transfected
R20212	T29180	T29181	themeOf	Akt,expression
R20570	T29678	T29683	causeOf	RIP1 kinase,dependent
R20571	T29678	T29684	causeOf	RIP1 kinase,dependent
R20572	T29679	T29681	themeOf	Akt,phosphorylation
R20573	T29680	T29682	themeOf	JNK,phosphorylation
R20574	T29681	T29683	themeOf	phosphorylation,dependent
R20575	T29682	T29684	themeOf	phosphorylation,dependent
R4602	T6918	T6919	themeOf	phosphorylation,increase
R4603	T6920	T6923	themeOf	Akt,increases
R4604	T6898	T6908	causeOf	IGF,increase
R4605	T6920	T6924	themeOf	Akt,phosphorylation
R4606	T6900	T6905	themeOf	Thr308,phosphorylation
R4607	T6901	T6909	causeOf	Akt,increase
R4608	T6921	T6925	themeOf	JNK,phosphorylation
R4609	T6903	T6906	themeOf	Fig,phosphorylation
R4610	T6904	T6907	themeOf	S3C,phosphorylation
R4611	T6905	T6908	themeOf	phosphorylation,increase
R4612	T6905	T6909	themeOf	phosphorylation,increase
R4613	T6906	T6910	themeOf	phosphorylation,increase
R4614	T6924	T6926	themeOf	phosphorylation,increases
R4615	T6907	T6911	themeOf	phosphorylation,increase
R4616	T6925	T6927	themeOf	phosphorylation,increases
R4617	T6912	T6917	themeOf	Akt Thr308,phosphorylation
R4618	T6913	T6919	causeOf	RIP1,increase
R4620	T6914	T6918	themeOf	Akt,phosphorylation

test3

Id	Subject	Object	Predicate	Lexical cue
T29398	3519-3523	Protein	denotes	bFGF
T29397	3355-3359	Protein	denotes	bFGF
T29396	3233-3237	Protein	denotes	TNFα
T29395	3137-3152	Phosphorylation	denotes	phosphorylation
T29394	3115-3119	Protein	denotes	RIP1
T29393	3527-3531	Protein	denotes	bFGF
T29392	3519-3523	Protein	denotes	bFGF
T29391	3355-3359	Protein	denotes	bFGF
T29390	3233-3237	Protein	denotes	TNFα
T29389	3115-3119	Protein	denotes	RIP1
T28942	1519-1529	Gene_expression	denotes	expression
T28941	1480-1484	Protein	denotes	TNFα
T28940	1427-1438	Protein	denotes	Akt3 siRNAs
T28939	1417-1421	Protein	denotes	Akt2
T28938	1411-1415	Protein	denotes	Akt1
T28937	1269-1278	Negative_regulation	denotes	inhibitor
T28936	1163-1167	Protein	denotes	TNFα
T28935	1112-1116	Protein	denotes	TNFα
T28934	1088-1095	Positive_regulation	denotes	induced
T28933	1480-1484	Protein	denotes	TNFα
T28932	1427-1438	Protein	denotes	Akt3 siRNAs
T28931	1417-1421	Protein	denotes	Akt2
T28930	1411-1415	Protein	denotes	Akt1
T28929	1163-1167	Protein	denotes	TNFα
T28928	1112-1116	Protein	denotes	TNFα
T29399	3527-3531	Protein	denotes	bFGF
T5276	6344-6348	Protein	denotes	RIP1
T5275	6194-6203	Positive_regulation	denotes	increases
T5274	6098-6113	Phosphorylation	denotes	phosphorylation
T5273	6075-6083	Positive_regulation	denotes	increase
T5272	6065-6074	Regulation	denotes	dependent
T5271	6060-6064	Protein	denotes	RIP1
T5270	5863-5878	Phosphorylation	denotes	phosphorylation
T5269	5851-5859	Positive_regulation	denotes	increase
T5268	5777-5792	Phosphorylation	denotes	phosphorylation
T5267	5758-5766	Positive_regulation	denotes	increase
T5266	5636-5640	Protein	denotes	RIP1
T5265	5565-5575	Positive_regulation	denotes	activation
T5264	5502-5510	Positive_regulation	denotes	increase
T5263	5492-5496	Protein	denotes	bFGF
T5262	5397-5401	Protein	denotes	bFGF
T5261	5388-5392	Protein	denotes	bFGF
T5260	5370-5379	Positive_regulation	denotes	triggered
T5259	5354-5369	Phosphorylation	denotes	phosphorylation
T5258	5348-5353	Protein	denotes	c-Jun
T5257	5319-5327	Positive_regulation	denotes	increase
T5256	5299-5305	Regulation	denotes	effect
T5255	5213-5221	Positive_regulation	denotes	increase
T5254	5142-5157	Phosphorylation	denotes	phosphorylation
T5253	5126-5134	Positive_regulation	denotes	increase
T5252	5076-5080	Protein	denotes	bFGF
T5251	5053-5057	Protein	denotes	bFGF
T5250	4925-4930	Protein	denotes	c-Jun
T5249	4883-4898	Phosphorylation	denotes	phosphorylation
T5248	4848-4856	Positive_regulation	denotes	increase
T5247	4764-4768	Protein	denotes	bFGF
T5246	4681-4696	Phosphorylation	denotes	phosphorylation
T5245	4620-4630	Regulation	denotes	regulation
T5244	4593-4597	Protein	denotes	RIP1
T5243	4410-4419	Positive_regulation	denotes	following
T5242	4351-4366	Phosphorylation	denotes	phosphorylation
T5241	4302-4311	Regulation	denotes	dependent
T5240	4297-4301	Protein	denotes	RIP1
T5239	4259-4274	Phosphorylation	denotes	phosphorylation
T5238	4163-4178	Phosphorylation	denotes	phosphorylation
T5237	4147-4152	Regulation	denotes	alter
T5236	4099-4109	Negative_regulation	denotes	attenuated
T5235	4082-4087	Protein	denotes	c-Jun
T5234	4070-4078	Positive_regulation	denotes	increase
T5233	4062-4069	Positive_regulation	denotes	induced
T5232	3984-3989	Protein	denotes	c-Jun
T5231	3909-3913	Protein	denotes	TNFα
T5230	3883-3890	Negative_regulation	denotes	reduced
T5229	3718-3733	Phosphorylation	denotes	phosphorylation
T5228	3714-3717	Protein	denotes	Akt
T5227	3695-3703	Positive_regulation	denotes	increase
T5226	3681-3690	Negative_regulation	denotes	prevented
T5225	3652-3661	Negative_regulation	denotes	inhibitor
T5224	3640-3644	Protein	denotes	RIP1
T5223	2968-2973	Protein	denotes	c-Jun
T5222	2924-2927	Protein	denotes	p54
T5221	2916-2919	Protein	denotes	p46
T5220	2888-2903	Phosphorylation	denotes	phosphorylation
T5219	2872-2880	Positive_regulation	denotes	increase
T5218	2820-2830	Positive_regulation	denotes	activation
T5217	2776-2791	Phosphorylation	denotes	phosphorylation
T5216	2662-2677	Phosphorylation	denotes	phosphorylation
T5215	2646-2654	Positive_regulation	denotes	increase
T5214	2620-2624	Protein	denotes	TNFα
T5213	2450-2454	Protein	denotes	TNFα
T5212	2407-2422	Phosphorylation	denotes	phosphorylation
T5211	2384-2391	Regulation	denotes	changes
T5210	2312-2322	Positive_regulation	denotes	activation
T5209	2136-2146	Protein	denotes	Akt3 siRNA
T5208	2078-2082	Protein	denotes	Akt3
T5207	2064-2074	Gene_expression	denotes	expression
T5206	2045-2049	Protein	denotes	TNFα
T5205	2016-2023	Positive_regulation	denotes	induced
T5204	1965-1969	Protein	denotes	Akt2
T5203	1956-1960	Protein	denotes	Akt1
T5202	1930-1939	Negative_regulation	denotes	knockdown
T5201	1846-1859	Localization	denotes	translocation
T5200	1724-1734	Negative_regulation	denotes	inhibitors
T5199	988-995	Positive_regulation	denotes	induced
T5198	983-987	Protein	denotes	TNFα
T5197	770-777	Positive_regulation	denotes	induced
T5196	765-769	Protein	denotes	TNFα
T5195	645-649	Protein	denotes	TNFα
T5194	552-562	Negative_regulation	denotes	Inhibition
T5193	498-503	Protein	denotes	IGF-1
T5192	490-494	Protein	denotes	bFGF
T5191	477-486	Positive_regulation	denotes	triggered
T5190	430-437	Positive_regulation	denotes	induced
T5189	344-353	Negative_regulation	denotes	inhibitor
T5188	321-331	Negative_regulation	denotes	Inhibition
T5187	22-32	Positive_regulation	denotes	Activation
T5185	6344-6348	Protein	denotes	RIP1
T5184	6060-6064	Protein	denotes	RIP1
T5183	5636-5640	Protein	denotes	RIP1
T5182	5492-5496	Protein	denotes	bFGF
T5181	5397-5401	Protein	denotes	bFGF
T5180	5388-5392	Protein	denotes	bFGF
T5179	5348-5353	Protein	denotes	c-Jun
T5178	5076-5080	Protein	denotes	bFGF
T5177	5053-5057	Protein	denotes	bFGF
T5176	4925-4930	Protein	denotes	c-Jun
T5175	4764-4768	Protein	denotes	bFGF
T5174	4593-4597	Protein	denotes	RIP1
T5173	4297-4301	Protein	denotes	RIP1
T5172	4082-4087	Protein	denotes	c-Jun
T5171	3984-3989	Protein	denotes	c-Jun
T5170	3909-3913	Protein	denotes	TNFα
T5169	3714-3717	Protein	denotes	Akt
T5168	3640-3644	Protein	denotes	RIP1
T5167	2968-2973	Protein	denotes	c-Jun
T5166	2924-2927	Protein	denotes	p54
T5165	2916-2919	Protein	denotes	p46
T5164	2620-2624	Protein	denotes	TNFα
T5163	2450-2454	Protein	denotes	TNFα
T5162	2136-2146	Protein	denotes	Akt3 siRNA
T5161	2078-2082	Protein	denotes	Akt3
T5160	2045-2049	Protein	denotes	TNFα
T5159	1965-1969	Protein	denotes	Akt2
T5158	1956-1960	Protein	denotes	Akt1
T5157	983-987	Protein	denotes	TNFα
T5156	765-769	Protein	denotes	TNFα
T5155	645-649	Protein	denotes	TNFα
T5154	498-503	Protein	denotes	IGF-1
T5153	490-494	Protein	denotes	bFGF
R3538	T5188	T5190	themeOf	Inhibition,induced
R3539	T5188	T5191	themeOf	Inhibition,triggered
R3540	T5193	T5191	causeOf	IGF-1,triggered
R3541	T5202	T5205	themeOf	knockdown,induced
R3542	T5203	T5202	themeOf	Akt1,knockdown
R3543	T5204	T5202	themeOf	Akt2,knockdown
R3544	T5206	T5205	causeOf	TNFα,induced
R3545	T5208	T5207	themeOf	Akt3,expression
R3546	T5216	T5215	themeOf	phosphorylation,increase
R3547	T5220	T5219	themeOf	phosphorylation,increase
R3548	T5221	T5220	themeOf	p46,phosphorylation
R3549	T5222	T5220	themeOf	p54,phosphorylation
R3550	T5223	T5220	themeOf	c-Jun,phosphorylation
R3551	T5224	T5225	themeOf	RIP1,inhibitor
R3552	T5225	T5227	causeOf	inhibitor,increase
R3553	T5225	T5226	causeOf	inhibitor,prevented
R3554	T5227	T5226	themeOf	increase,prevented
R3555	T5228	T5229	themeOf	Akt,phosphorylation
R3556	T5229	T5227	themeOf	phosphorylation,increase
R3557	T5233	T5236	themeOf	induced,attenuated
R3558	T5234	T5233	themeOf	increase,induced
R3559	T5235	T5234	themeOf	c-Jun,increase
R3560	T5235	T5236	themeOf	c-Jun,attenuated
R3561	T5238	T5237	themeOf	phosphorylation,alter
R3562	T5239	T5241	themeOf	phosphorylation,dependent
R3563	T5240	T5239	themeOf	RIP1,phosphorylation
R3564	T5242	T5243	themeOf	phosphorylation,following
R3565	T5249	T5248	themeOf	phosphorylation,increase
R3566	T5250	T5249	themeOf	c-Jun,phosphorylation
R3567	T5252	T5253	causeOf	bFGF,increase
R3568	T5254	T5253	themeOf	phosphorylation,increase
R3569	T5258	T5259	themeOf	c-Jun,phosphorylation
R3570	T5259	T5257	themeOf	phosphorylation,increase
R3571	T5260	T5257	themeOf	triggered,increase
R3572	T5261	T5260	causeOf	bFGF,triggered
R3573	T5262	T5260	causeOf	bFGF,triggered
R3574	T5263	T5264	causeOf	bFGF,increase
R3575	T5268	T5267	themeOf	phosphorylation,increase
R3576	T5270	T5269	themeOf	phosphorylation,increase
R3577	T5271	T5272	causeOf	RIP1,dependent
R3578	T5273	T5272	themeOf	increase,dependent
R3579	T5274	T5273	themeOf	phosphorylation,increase

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