PMC:3567831 / 3878-6012 JSON TXT

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0_colil

{"project":"0_colil","denotations":[{"id":"22761504-22068435-6862","span":{"begin":929,"end":930},"obj":"22068435"},{"id":"22761504-17483110-6863","span":{"begin":932,"end":933},"obj":"17483110"},{"id":"22761504-16053960-6864","span":{"begin":935,"end":936},"obj":"16053960"},{"id":"22761504-2978807-6865","span":{"begin":1748,"end":1749},"obj":"2978807"},{"id":"22761504-15824202-6866","span":{"begin":1751,"end":1752},"obj":"15824202"}],"text":"Patient sample\nThis study was carried out in 93 consecutive obstructive HCM patients treated surgically in Fuwai Hospital (Beijing), National Center for Cardiovascular Diseases, China, from October 2009 to December 2011.\nAll the patients were diagnosed by transthoracic echocardiography (TTE). Surgery was performed to relieve obstruction of LVOT, and the patients were eligible for inclusion in surgical intervention if they met the following two criteria: (i) under Doppler TTE, a LVOT gradient of ≥50 mmHg at rest or with physiological provocation; (ii) unresponsive to maximum pharmacological therapy, including dyspnoea with New York Heart Association (NYHA) functional class II to IV and/or chest pain with Canadian Cardiovascular Society Angina class III or IV, and/or repetitive effort-related syncope despite prior appropriate medical therapy. The inclusion criteria were much the same as international common practice [1, 5, 6]. The baseline clinical variables of this group of patients are shown in Table 1.\nTable 1: Baseline clinical and demographic data (n = 93)\nParameter Mean value (range) or number (%)\nAge (years) 45.78 ± 13.39\nBody weight (kg) 67.83 ± 13.69\nMale 57 (61.3%)\nPreoperative symptoms\n Exertional dyspnea 84 (90.3%)\n Chest discomfort 67 (72.0%)\n Palpitation 17 (18.3%)\n Syncope/presyncope 16 (17.2%)\nMedical therapy\n Beta-blocker 93 (100%)\n Calcium blocker 67 (72.0%)\nPrevious alcohol ablation 3 (3.2%)\nLVOT: left ventricular outflow tract.\nSurgery was not performed in the patients who did not meet the criteria for surgery, which was insignificant LVOT obstruction or minimal symptoms, or medical therapy was effective already.\nPreoperative and postoperative TTE were performed with commercially available equipment [7, 8]. The clinical symptoms, haemodynamic status and echocardiographic information [LVOT gradient, interventricular septum thickness, degree of mitral regurgitation (MR) and aortic regurgitation, etc.] of each patient were documented and analysed before and after TAESM. Moreover, TEE was done intraoperatively to assess and document relief from LVOT obstruction and MR after myectomy."}

TEST0

{"project":"TEST0","denotations":[{"id":"22761504-76-81-6862","span":{"begin":929,"end":930},"obj":"[\"22068435\"]"},{"id":"22761504-79-84-6863","span":{"begin":932,"end":933},"obj":"[\"17483110\"]"},{"id":"22761504-82-87-6864","span":{"begin":935,"end":936},"obj":"[\"16053960\"]"},{"id":"22761504-89-94-6865","span":{"begin":1748,"end":1749},"obj":"[\"2978807\"]"},{"id":"22761504-92-97-6866","span":{"begin":1751,"end":1752},"obj":"[\"15824202\"]"}],"text":"Patient sample\nThis study was carried out in 93 consecutive obstructive HCM patients treated surgically in Fuwai Hospital (Beijing), National Center for Cardiovascular Diseases, China, from October 2009 to December 2011.\nAll the patients were diagnosed by transthoracic echocardiography (TTE). Surgery was performed to relieve obstruction of LVOT, and the patients were eligible for inclusion in surgical intervention if they met the following two criteria: (i) under Doppler TTE, a LVOT gradient of ≥50 mmHg at rest or with physiological provocation; (ii) unresponsive to maximum pharmacological therapy, including dyspnoea with New York Heart Association (NYHA) functional class II to IV and/or chest pain with Canadian Cardiovascular Society Angina class III or IV, and/or repetitive effort-related syncope despite prior appropriate medical therapy. The inclusion criteria were much the same as international common practice [1, 5, 6]. The baseline clinical variables of this group of patients are shown in Table 1.\nTable 1: Baseline clinical and demographic data (n = 93)\nParameter Mean value (range) or number (%)\nAge (years) 45.78 ± 13.39\nBody weight (kg) 67.83 ± 13.69\nMale 57 (61.3%)\nPreoperative symptoms\n Exertional dyspnea 84 (90.3%)\n Chest discomfort 67 (72.0%)\n Palpitation 17 (18.3%)\n Syncope/presyncope 16 (17.2%)\nMedical therapy\n Beta-blocker 93 (100%)\n Calcium blocker 67 (72.0%)\nPrevious alcohol ablation 3 (3.2%)\nLVOT: left ventricular outflow tract.\nSurgery was not performed in the patients who did not meet the criteria for surgery, which was insignificant LVOT obstruction or minimal symptoms, or medical therapy was effective already.\nPreoperative and postoperative TTE were performed with commercially available equipment [7, 8]. The clinical symptoms, haemodynamic status and echocardiographic information [LVOT gradient, interventricular septum thickness, degree of mitral regurgitation (MR) and aortic regurgitation, etc.] of each patient were documented and analysed before and after TAESM. Moreover, TEE was done intraoperatively to assess and document relief from LVOT obstruction and MR after myectomy."}

2_test

{"project":"2_test","denotations":[{"id":"22761504-22068435-28905028","span":{"begin":929,"end":930},"obj":"22068435"},{"id":"22761504-17483110-28905029","span":{"begin":932,"end":933},"obj":"17483110"},{"id":"22761504-16053960-28905030","span":{"begin":935,"end":936},"obj":"16053960"},{"id":"22761504-2978807-28905031","span":{"begin":1748,"end":1749},"obj":"2978807"},{"id":"22761504-15824202-28905032","span":{"begin":1751,"end":1752},"obj":"15824202"}],"text":"Patient sample\nThis study was carried out in 93 consecutive obstructive HCM patients treated surgically in Fuwai Hospital (Beijing), National Center for Cardiovascular Diseases, China, from October 2009 to December 2011.\nAll the patients were diagnosed by transthoracic echocardiography (TTE). Surgery was performed to relieve obstruction of LVOT, and the patients were eligible for inclusion in surgical intervention if they met the following two criteria: (i) under Doppler TTE, a LVOT gradient of ≥50 mmHg at rest or with physiological provocation; (ii) unresponsive to maximum pharmacological therapy, including dyspnoea with New York Heart Association (NYHA) functional class II to IV and/or chest pain with Canadian Cardiovascular Society Angina class III or IV, and/or repetitive effort-related syncope despite prior appropriate medical therapy. The inclusion criteria were much the same as international common practice [1, 5, 6]. The baseline clinical variables of this group of patients are shown in Table 1.\nTable 1: Baseline clinical and demographic data (n = 93)\nParameter Mean value (range) or number (%)\nAge (years) 45.78 ± 13.39\nBody weight (kg) 67.83 ± 13.69\nMale 57 (61.3%)\nPreoperative symptoms\n Exertional dyspnea 84 (90.3%)\n Chest discomfort 67 (72.0%)\n Palpitation 17 (18.3%)\n Syncope/presyncope 16 (17.2%)\nMedical therapy\n Beta-blocker 93 (100%)\n Calcium blocker 67 (72.0%)\nPrevious alcohol ablation 3 (3.2%)\nLVOT: left ventricular outflow tract.\nSurgery was not performed in the patients who did not meet the criteria for surgery, which was insignificant LVOT obstruction or minimal symptoms, or medical therapy was effective already.\nPreoperative and postoperative TTE were performed with commercially available equipment [7, 8]. The clinical symptoms, haemodynamic status and echocardiographic information [LVOT gradient, interventricular septum thickness, degree of mitral regurgitation (MR) and aortic regurgitation, etc.] of each patient were documented and analysed before and after TAESM. Moreover, TEE was done intraoperatively to assess and document relief from LVOT obstruction and MR after myectomy."}

MyTest

{"project":"MyTest","denotations":[{"id":"22761504-22068435-28905028","span":{"begin":929,"end":930},"obj":"22068435"},{"id":"22761504-17483110-28905029","span":{"begin":932,"end":933},"obj":"17483110"},{"id":"22761504-16053960-28905030","span":{"begin":935,"end":936},"obj":"16053960"},{"id":"22761504-2978807-28905031","span":{"begin":1748,"end":1749},"obj":"2978807"},{"id":"22761504-15824202-28905032","span":{"begin":1751,"end":1752},"obj":"15824202"}],"namespaces":[{"prefix":"_base","uri":"https://www.uniprot.org/uniprot/testbase"},{"prefix":"UniProtKB","uri":"https://www.uniprot.org/uniprot/"},{"prefix":"uniprot","uri":"https://www.uniprot.org/uniprotkb/"}],"text":"Patient sample\nThis study was carried out in 93 consecutive obstructive HCM patients treated surgically in Fuwai Hospital (Beijing), National Center for Cardiovascular Diseases, China, from October 2009 to December 2011.\nAll the patients were diagnosed by transthoracic echocardiography (TTE). Surgery was performed to relieve obstruction of LVOT, and the patients were eligible for inclusion in surgical intervention if they met the following two criteria: (i) under Doppler TTE, a LVOT gradient of ≥50 mmHg at rest or with physiological provocation; (ii) unresponsive to maximum pharmacological therapy, including dyspnoea with New York Heart Association (NYHA) functional class II to IV and/or chest pain with Canadian Cardiovascular Society Angina class III or IV, and/or repetitive effort-related syncope despite prior appropriate medical therapy. The inclusion criteria were much the same as international common practice [1, 5, 6]. The baseline clinical variables of this group of patients are shown in Table 1.\nTable 1: Baseline clinical and demographic data (n = 93)\nParameter Mean value (range) or number (%)\nAge (years) 45.78 ± 13.39\nBody weight (kg) 67.83 ± 13.69\nMale 57 (61.3%)\nPreoperative symptoms\n Exertional dyspnea 84 (90.3%)\n Chest discomfort 67 (72.0%)\n Palpitation 17 (18.3%)\n Syncope/presyncope 16 (17.2%)\nMedical therapy\n Beta-blocker 93 (100%)\n Calcium blocker 67 (72.0%)\nPrevious alcohol ablation 3 (3.2%)\nLVOT: left ventricular outflow tract.\nSurgery was not performed in the patients who did not meet the criteria for surgery, which was insignificant LVOT obstruction or minimal symptoms, or medical therapy was effective already.\nPreoperative and postoperative TTE were performed with commercially available equipment [7, 8]. The clinical symptoms, haemodynamic status and echocardiographic information [LVOT gradient, interventricular septum thickness, degree of mitral regurgitation (MR) and aortic regurgitation, etc.] of each patient were documented and analysed before and after TAESM. Moreover, TEE was done intraoperatively to assess and document relief from LVOT obstruction and MR after myectomy."}

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