PMC:3514855 / 15672-16759 JSONTXT

{"target":"http://pubannotation.org/docs/sourcedb/PMC/sourceid/3514855","sourcedb":"PMC","sourceid":"3514855","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3514855","text":"Another transversion, in argB (slr1898; #8 in Table 1), leads to an S2N amino acid substitution in N-acetylglutamate kinase, the enzyme performing the first committed step of Arg biosynthesis. Transitions in sll1359 and slr1609 (#11 and #3 in Table 1) result in an N–K substitution at a very conserved position within a predicted cytochrome and an L608S (L548S) substitution in the long-chain acyl-CoA-synthetase Slr1609 that has been found crucial for fatty acid activation and the biosynthesis of alkanes.32 Interestingly, an unrelated SNP exists at position 488 923 within the slr1609 coding sequence in a strain ‘YF’, leading to a G546L (G486L) substitution.17 It should be noted that the slr1609 reading frame has been annotated 60 codons shorter (636 instead of 696 amino acids) during recent re-sequencing analyses,9,10 compared with the original annotation of ‘GT-Kazusa’ (numbers in brackets). The shorter Slr1609 protein of 636 amino acids is also consistent with the mapped start site of transcription at position 487 352,33 located 115 nt upstream of the revised start codon.","tracks":[{"project":"2_test","denotations":[{"id":"23069868-22433663-25970107","span":{"begin":507,"end":509},"obj":"22433663"},{"id":"23069868-22375005-25970108","span":{"begin":662,"end":664},"obj":"22375005"},{"id":"23069868-22193367-25970109","span":{"begin":822,"end":823},"obj":"22193367"},{"id":"23069868-21803841-25970110","span":{"begin":824,"end":826},"obj":"21803841"},{"id":"23069868-21245330-25970111","span":{"begin":1033,"end":1035},"obj":"21245330"}],"attributes":[{"subj":"23069868-22433663-25970107","pred":"source","obj":"2_test"},{"subj":"23069868-22375005-25970108","pred":"source","obj":"2_test"},{"subj":"23069868-22193367-25970109","pred":"source","obj":"2_test"},{"subj":"23069868-21803841-25970110","pred":"source","obj":"2_test"},{"subj":"23069868-21245330-25970111","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#eca293","default":true}]}]}}