PMC:3480684 / 7409-8362 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3480684","sourcedb":"PMC","sourceid":"3480684","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3480684","text":"Association analysis\nIn performing the association tests, SNPs were analyzed with PLINK (http://pngu.mgh.harvard.edu/~purcell/plink/) and SAS version 9.1 (SAS institute Inc., Cary, NC, USA). Individuals who were on lipid-lowering therapy and hypertensive medications were excluded for dyslipidemia-related phenotypes, such as TG, HDL-C, and LDL-C. LDL-C concentrations were calculated with Friedewald's formula [18]. Missing values were assigned for individuals with TG over 400 mg/dL. The dyslipidemia-related phenotypes were tested by multivariate linear regression analysis in an additive genetic model (1-d.f.), including age, sex, and recruitment area as covariates. TG and HDL-C were transformed prior to analysis using natural log transformation to remove skewing. LDL-C was normally distributed, and no transformations were required. A GRS was examined using multivariate linear regression analysis, adjusting for age, sex, and recruitment area.","divisions":[{"label":"Title","span":{"begin":0,"end":20}}],"tracks":[{"project":"2_test","denotations":[{"id":"23105936-9365406-44845782","span":{"begin":412,"end":414},"obj":"9365406"}],"attributes":[{"subj":"23105936-9365406-44845782","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#dcec93","default":true}]}]}}