PMC:3480684 / 1786-3733 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3480684","sourcedb":"PMC","sourceid":"3480684","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3480684","text":"Introduction\nDyslipidemia is an important etiological factor in the development of cardiovascular disease (CVD), which is the leading cause of deaths for adults. Dyslipidemia is mainly characterized by elevated levels of triglycerides (TGs), increased low-density lipoprotein cholesterol (LDL-C), and reduced high-density lipoprotein cholesterol (HDL-C) [1].\nIn the past few years, genome-wide association studies (GWASs) and meta-analyses have identified common genetic variants that contribute to blood lipid phenotypes in Caucasian-based populations [2-8]. In addition, we have convincingly mapped 16 loci for major lipoprotein concentrations (TG, HDL-C, and LDL-C) in a two-stage association study in individuals of East Asian ancestry [9].\nGiven the growing global epidemic of metabolic syndrome, including obesity and type 2 diabetes (T2D), lipoprotein metabolism disorders have become an important health problem in adulthood but also have emerged as an increasingly prevalent risk factor in childhood [10]. Although many GWASs and meta-analyses have provided susceptibility genes or loci for lipid-related traits from multiple large population-based cohorts of adults, it is of great importance to evaluate genetic predisposition at an early age. However, little is known about their genetic effects in a younger population. Moreover, most identified variants have shown modest effects and have explained only a small proportion of heritable components for disease risk [11]. Nevertheless, when multiple genetic markers are considered together, literature-based genetic risk scores might be useful in improving the identification of the genetic contribution in those at high risk of disease [12-14]. Therefore, the aim of this study was to consolidate the associations of GWAS-based candidate variants with blood lipid concentrations in a childhood obesity study and to evaluate genetic risk scores (GRS) for lipid-related risk phenotypes.","divisions":[{"label":"Title","span":{"begin":0,"end":12}}],"tracks":[{"project":"2_test","denotations":[{"id":"23105936-15575034-44845770","span":{"begin":355,"end":356},"obj":"15575034"},{"id":"23105936-22399527-44845771","span":{"begin":554,"end":555},"obj":"22399527"},{"id":"23105936-22171074-44845771","span":{"begin":554,"end":555},"obj":"22171074"},{"id":"23105936-19060911-44845771","span":{"begin":554,"end":555},"obj":"19060911"},{"id":"23105936-18193044-44845771","span":{"begin":554,"end":555},"obj":"18193044"},{"id":"23105936-19060906-44845771","span":{"begin":554,"end":555},"obj":"19060906"},{"id":"23105936-18193043-44845771","span":{"begin":554,"end":555},"obj":"18193043"},{"id":"23105936-17463246-44845771","span":{"begin":554,"end":555},"obj":"17463246"},{"id":"23105936-21909109-44845772","span":{"begin":741,"end":742},"obj":"21909109"},{"id":"23105936-22484627-44845773","span":{"begin":1010,"end":1012},"obj":"22484627"},{"id":"23105936-22223662-44845774","span":{"begin":1479,"end":1481},"obj":"22223662"},{"id":"23105936-20980472-44845775","span":{"begin":1700,"end":1702},"obj":"20980472"},{"id":"23105936-21242481-44845775","span":{"begin":1700,"end":1702},"obj":"21242481"},{"id":"23105936-22373668-44845775","span":{"begin":1700,"end":1702},"obj":"22373668"}],"attributes":[{"subj":"23105936-15575034-44845770","pred":"source","obj":"2_test"},{"subj":"23105936-22399527-44845771","pred":"source","obj":"2_test"},{"subj":"23105936-22171074-44845771","pred":"source","obj":"2_test"},{"subj":"23105936-19060911-44845771","pred":"source","obj":"2_test"},{"subj":"23105936-18193044-44845771","pred":"source","obj":"2_test"},{"subj":"23105936-19060906-44845771","pred":"source","obj":"2_test"},{"subj":"23105936-18193043-44845771","pred":"source","obj":"2_test"},{"subj":"23105936-17463246-44845771","pred":"source","obj":"2_test"},{"subj":"23105936-21909109-44845772","pred":"source","obj":"2_test"},{"subj":"23105936-22484627-44845773","pred":"source","obj":"2_test"},{"subj":"23105936-22223662-44845774","pred":"source","obj":"2_test"},{"subj":"23105936-20980472-44845775","pred":"source","obj":"2_test"},{"subj":"23105936-21242481-44845775","pred":"source","obj":"2_test"},{"subj":"23105936-22373668-44845775","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93d2","default":true}]}]}}