PMC:3480682 / 20557-21855 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3480682","sourcedb":"PMC","sourceid":"3480682","source_url":"https://www.ncbi.nlm.nih.gov/pmc/3480682","text":"Empirical distribution of FST\nTo assess population differentiation with an allele frequency spectrum of CNVs, the locus-specific estimates by ANOVA method and by hierarchical Bayesian method were obtained from all autosomes. The estimated values by the ANOVA method (moments estimates) can be negative when levels of differentiation are close to 0 and/or sample sizes are small, indicating no population differentiation at these loci [18]. In the hierarchical Bayesian method, the locus-specific estimate values are all positive, since they are generated by posterior distributions, which is an important benefit of a Bayesian method.\nWith the CNV data of this study, the summary statistics of FST was 0.0853 ± 0.1195 (median, 0.0360; range, -0.0071 to 0.8994) for the ANOVA method and 0.2459 ± 0.0115 (median, 0.2462; range, 0.2193 to 0.6166) for the Bayesian method. The empirical distributions of FST are found in Fig. 1. As can be seen from the Figure, low FST values are prevalent, and a large variability persisted in the ANOVA method, while FST distribution was sharply focused in the Bayesian method. The comparison of empirical distributions of the ANOVA and Bayesian methods demonstrates that Bayesian estimates perform better than ANOVA in identifying CNVs affected by natural selection.","divisions":[{"label":"Title","span":{"begin":0,"end":29}}],"tracks":[]}