PMC:3431878 / 4400-5407 JSONTXT

{"project":"2_test","denotations":[{"id":"22949880-12734200-50810643","span":{"begin":293,"end":294},"obj":"12734200"},{"id":"22949880-16126266-50810644","span":{"begin":486,"end":487},"obj":"16126266"},{"id":"22949880-17617155-50810645","span":{"begin":645,"end":646},"obj":"17617155"},{"id":"22949880-17617155-50810646","span":{"begin":795,"end":796},"obj":"17617155"},{"id":"22949880-10801862-50810647","span":{"begin":1000,"end":1002},"obj":"10801862"},{"id":"22949880-20497550-50810648","span":{"begin":1003,"end":1005},"obj":"20497550"},{"id":"T36741","span":{"begin":293,"end":294},"obj":"12734200"},{"id":"T93477","span":{"begin":486,"end":487},"obj":"16126266"},{"id":"T22450","span":{"begin":645,"end":646},"obj":"17617155"},{"id":"T55741","span":{"begin":795,"end":796},"obj":"17617155"},{"id":"T34912","span":{"begin":1000,"end":1002},"obj":"10801862"},{"id":"T12843","span":{"begin":1003,"end":1005},"obj":"20497550"}],"text":"The biological role for CA125 is still under investigation though several studies have demonstrated a relationship between CA125 and the immune system. In 2003 Kui Wong et al. proposed a role in immunity based upon the characterization of the N-oligosaccharide structures identified on CA125 [7]. This hypothesis was supported by the study of Patankar et al. where natural killer (NK) cell function was found to be inhibited in the presence of CA125 purified from OVCAR-3 cell culture [8]. Cell membrane-bound CA125 was subsequently shown to bind directly to NK cells derived from peripheral blood of ovarian cancer patients and pregnant women [9]. A potential link between the suppression of NK cells in feto-maternal tolerance and the immune evasion of ovarian cancers was therefore proposed [9]. Further investigation into the mechanism of interaction revealed that binding was established through the sialic acid-binding Ig-like lectin-9 (Siglec-9), an inhibitory receptor expressed on NK cells [10,11]."}