PMC:3431878 / 18832-19478 JSONTXT

{"project":"2_test","denotations":[{"id":"22949880-1962150-50810728","span":{"begin":53,"end":55},"obj":"1962150"},{"id":"22949880-1962150-50810729","span":{"begin":176,"end":178},"obj":"1962150"},{"id":"22949880-12734200-50810730","span":{"begin":277,"end":278},"obj":"12734200"},{"id":"22949880-12734200-50810731","span":{"begin":389,"end":390},"obj":"12734200"},{"id":"22949880-10770931-50810732","span":{"begin":391,"end":393},"obj":"10770931"},{"id":"T46426","span":{"begin":53,"end":55},"obj":"1962150"},{"id":"T22304","span":{"begin":176,"end":178},"obj":"1962150"},{"id":"T72102","span":{"begin":277,"end":278},"obj":"12734200"},{"id":"T3414","span":{"begin":389,"end":390},"obj":"12734200"},{"id":"T52697","span":{"begin":391,"end":393},"obj":"10770931"}],"text":"A third view was presented by Nagata et al. in 1991 [44]. They found CA125 to be a glycosylphosphatidylinositol (GPI) anchored molecule with N- and O-linked glycan structures [44]. Independently, a study by Kui Wong et al. also found N- and O-linked glycans attached to CA125 [7]. Interestingly, one identified structure was identical to an unusual glycostructure expressed by uromodulin [7,45]. In light of our recent results these contradicting reports may arise from cross-reactivity of the M11-like and OC125-like antibodies with other proteins [41]. This may have lead to the characterization of proteins that were wrongly assigned as CA125."}