PMC:3431878 / 14182-15018 JSONTXT

{"project":"2_test","denotations":[{"id":"22949880-11786729-50810697","span":{"begin":124,"end":126},"obj":"11786729"},{"id":"22949880-8685601-50810698","span":{"begin":127,"end":129},"obj":"8685601"},{"id":"22949880-12595747-50810699","span":{"begin":130,"end":132},"obj":"12595747"},{"id":"22949880-11786729-50810700","span":{"begin":197,"end":199},"obj":"11786729"},{"id":"22949880-14764598-50810701","span":{"begin":357,"end":359},"obj":"14764598"},{"id":"22949880-20563897-50810702","span":{"begin":455,"end":457},"obj":"20563897"},{"id":"22949880-20563897-50810703","span":{"begin":553,"end":555},"obj":"20563897"},{"id":"22949880-20563897-50810704","span":{"begin":832,"end":834},"obj":"20563897"},{"id":"T30798","span":{"begin":124,"end":126},"obj":"11786729"},{"id":"T21976","span":{"begin":127,"end":129},"obj":"8685601"},{"id":"T26462","span":{"begin":130,"end":132},"obj":"12595747"},{"id":"T96616","span":{"begin":197,"end":199},"obj":"11786729"},{"id":"T43024","span":{"begin":357,"end":359},"obj":"14764598"},{"id":"T47401","span":{"begin":455,"end":457},"obj":"20563897"},{"id":"T64359","span":{"begin":553,"end":555},"obj":"20563897"},{"id":"T60980","span":{"begin":832,"end":834},"obj":"20563897"}],"text":"OC125-like and M11-like antibodies are proposed to detect a cysteine enclosed loop (C-loop) structure in the repeat domain [18,31,32] with a paucity of glyco-structures in the immediate proximity [18]. Extrapolated from the C-loop of a murine derived CA125 repeat domain homolog, Maeda et al. suggested that this antigenic region forms a β-sheet structure [22]. This was later confirmed with a synthesized 21 amino acid long human CA125 antigenic domain [23]. Here, a serine in position 8 of the loop was found to be essential for structural formation [23]. However, it is important to note that this serine at position 8 is conserved in the repeat sequences, throughout human CA125, in only around 25% of the cases. In approximately 60% of repeat sequences a proline is found at position 8, which results in random coil formation [23]."}