Id |
Subject |
Object |
Predicate |
Lexical cue |
T284 |
0-3 |
DT |
denotes |
The |
T285 |
14-19 |
NNS |
denotes |
genes |
T286 |
4-8 |
CD |
denotes |
four |
T287 |
9-13 |
NN |
denotes |
Acdp |
T288 |
52-59 |
VBP |
denotes |
contain |
T289 |
20-21 |
-LRB- |
denotes |
( |
T290 |
21-26 |
NN |
denotes |
Acdp1 |
T291 |
26-28 |
, |
denotes |
, |
T292 |
28-33 |
NN |
denotes |
Acdp2 |
T293 |
33-35 |
, |
denotes |
, |
T294 |
35-40 |
NN |
denotes |
Acdp3 |
T295 |
41-44 |
CC |
denotes |
and |
T296 |
45-50 |
NN |
denotes |
Acdp4 |
T297 |
50-51 |
-RRB- |
denotes |
) |
T298 |
60-65 |
CD |
denotes |
3,631 |
T299 |
66-68 |
NNS |
denotes |
bp |
T300 |
68-70 |
, |
denotes |
, |
T301 |
70-75 |
CD |
denotes |
3,244 |
T302 |
76-78 |
NNS |
denotes |
bp |
T303 |
78-80 |
, |
denotes |
, |
T304 |
80-85 |
CD |
denotes |
2,684 |
T305 |
86-88 |
NNS |
denotes |
bp |
T306 |
89-92 |
CC |
denotes |
and |
T307 |
93-98 |
CD |
denotes |
2,743 |
T308 |
99-101 |
NNS |
denotes |
bp |
T309 |
102-104 |
IN |
denotes |
of |
T310 |
105-109 |
NN |
denotes |
cDNA |
T311 |
110-119 |
NNS |
denotes |
sequences |
T312 |
119-121 |
, |
denotes |
, |
T313 |
121-124 |
CC |
denotes |
and |
T314 |
125-131 |
VBP |
denotes |
encode |
T315 |
132-139 |
VBN |
denotes |
deduced |
T316 |
140-148 |
NN |
denotes |
proteins |
T317 |
149-151 |
IN |
denotes |
of |
T318 |
152-155 |
CD |
denotes |
951 |
T319 |
180-185 |
NNS |
denotes |
acids |
T320 |
155-157 |
, |
denotes |
, |
T321 |
157-160 |
CD |
denotes |
874 |
T322 |
160-162 |
, |
denotes |
, |
T323 |
162-165 |
CD |
denotes |
713 |
T324 |
166-169 |
CC |
denotes |
and |
T325 |
170-173 |
CD |
denotes |
771 |
T326 |
174-179 |
NN |
denotes |
amino |
T327 |
185-187 |
, |
denotes |
, |
T328 |
187-199 |
RB |
denotes |
respectively |
T329 |
199-200 |
. |
denotes |
. |
T330 |
200-331 |
sentence |
denotes |
The mouse Acdp genes showed very strong homologies (>90%) in both nucleotide and amino acid sequences to their human counterparts. |
T331 |
201-204 |
DT |
denotes |
The |
T332 |
216-221 |
NNS |
denotes |
genes |
T333 |
205-210 |
NN |
denotes |
mouse |
T334 |
211-215 |
NN |
denotes |
Acdp |
T335 |
222-228 |
VBD |
denotes |
showed |
T336 |
229-233 |
RB |
denotes |
very |
T337 |
234-240 |
JJ |
denotes |
strong |
T338 |
241-251 |
NNS |
denotes |
homologies |
T339 |
252-253 |
-LRB- |
denotes |
( |
T340 |
256-257 |
NN |
denotes |
% |
T341 |
253-254 |
SYM |
denotes |
> |
T342 |
254-256 |
CD |
denotes |
90 |
T343 |
257-258 |
-RRB- |
denotes |
) |
T344 |
259-261 |
IN |
denotes |
in |
T345 |
262-266 |
CC |
denotes |
both |
T346 |
267-277 |
NN |
denotes |
nucleotide |
T347 |
293-302 |
NNS |
denotes |
sequences |
T348 |
278-281 |
CC |
denotes |
and |
T349 |
282-287 |
NN |
denotes |
amino |
T350 |
288-292 |
NN |
denotes |
acid |
T351 |
303-305 |
IN |
denotes |
to |
T352 |
306-311 |
PRP$ |
denotes |
their |
T353 |
318-330 |
NNS |
denotes |
counterparts |
T354 |
312-317 |
JJ |
denotes |
human |
T355 |
330-331 |
. |
denotes |
. |
T356 |
331-485 |
sentence |
denotes |
In addition, both nucleotide and amino acid sequences within the Ancient Conserved Domain (ACD) are highly conserved in many different taxonomic species. |
T357 |
332-334 |
IN |
denotes |
In |
T358 |
439-448 |
VBN |
denotes |
conserved |
T359 |
335-343 |
NN |
denotes |
addition |
T360 |
343-345 |
, |
denotes |
, |
T361 |
345-349 |
CC |
denotes |
both |
T362 |
350-360 |
NN |
denotes |
nucleotide |
T363 |
376-385 |
NNS |
denotes |
sequences |
T364 |
361-364 |
CC |
denotes |
and |
T365 |
365-370 |
NN |
denotes |
amino |
T366 |
371-375 |
NN |
denotes |
acid |
T367 |
386-392 |
IN |
denotes |
within |
T368 |
393-396 |
DT |
denotes |
the |
T369 |
415-421 |
NN |
denotes |
Domain |
T370 |
397-404 |
JJ |
denotes |
Ancient |
T371 |
405-414 |
VBN |
denotes |
Conserved |
T372 |
422-423 |
-LRB- |
denotes |
( |
T373 |
423-426 |
NN |
denotes |
ACD |
T374 |
426-427 |
-RRB- |
denotes |
) |
T375 |
428-431 |
VBP |
denotes |
are |
T376 |
432-438 |
RB |
denotes |
highly |
T377 |
449-451 |
IN |
denotes |
in |
T378 |
452-456 |
JJ |
denotes |
many |
T379 |
477-484 |
NNS |
denotes |
species |
T380 |
457-466 |
JJ |
denotes |
different |
T381 |
467-476 |
JJ |
denotes |
taxonomic |
T382 |
484-485 |
. |
denotes |
. |
T383 |
485-662 |
sentence |
denotes |
Particularly, Acdp proteins showed very strong AA homologies to the bacteria CorC protein (35% AA identity with 55% homology), which is involved in magnesium and cobalt efflux. |
T384 |
486-498 |
RB |
denotes |
Particularly |
T385 |
514-520 |
VBD |
denotes |
showed |
T386 |
498-500 |
, |
denotes |
, |
T387 |
500-504 |
NN |
denotes |
Acdp |
T388 |
505-513 |
NN |
denotes |
proteins |
T389 |
521-525 |
RB |
denotes |
very |
T390 |
526-532 |
JJ |
denotes |
strong |
T391 |
536-546 |
NNS |
denotes |
homologies |
T392 |
533-535 |
NN |
denotes |
AA |
T393 |
547-549 |
IN |
denotes |
to |
T394 |
550-553 |
DT |
denotes |
the |
T395 |
568-575 |
NN |
denotes |
protein |
T396 |
554-562 |
NNS |
denotes |
bacteria |
T397 |
563-567 |
NN |
denotes |
CorC |
T398 |
576-577 |
-LRB- |
denotes |
( |
T399 |
584-592 |
NN |
denotes |
identity |
T400 |
577-579 |
CD |
denotes |
35 |
T401 |
579-580 |
NN |
denotes |
% |
T402 |
581-583 |
NN |
denotes |
AA |
T403 |
593-597 |
IN |
denotes |
with |
T404 |
598-600 |
CD |
denotes |
55 |
T405 |
600-601 |
NN |
denotes |
% |
T406 |
602-610 |
NN |
denotes |
homology |
T407 |
610-611 |
-RRB- |
denotes |
) |
T408 |
611-613 |
, |
denotes |
, |
T409 |
613-618 |
WDT |
denotes |
which |
T410 |
622-630 |
VBN |
denotes |
involved |
T411 |
619-621 |
VBZ |
denotes |
is |
T412 |
631-633 |
IN |
denotes |
in |
T413 |
634-643 |
NN |
denotes |
magnesium |
T414 |
655-661 |
NN |
denotes |
efflux |
T415 |
644-647 |
CC |
denotes |
and |
T416 |
648-654 |
NN |
denotes |
cobalt |
T417 |
661-662 |
. |
denotes |
. |
T418 |
662-834 |
sentence |
denotes |
The Acdp genes are widely expressed in all tissues tested except for Acdp1, which is only highly expressed in the brain with low levels of expression in kidney and testis. |
T419 |
663-666 |
DT |
denotes |
The |
T420 |
672-677 |
NNS |
denotes |
genes |
T421 |
667-671 |
NN |
denotes |
Acdp |
T422 |
689-698 |
VBN |
denotes |
expressed |
T423 |
678-681 |
VBP |
denotes |
are |
T424 |
682-688 |
RB |
denotes |
widely |
T425 |
699-701 |
IN |
denotes |
in |
T426 |
702-705 |
DT |
denotes |
all |
T427 |
706-713 |
NNS |
denotes |
tissues |
T428 |
714-720 |
VBN |
denotes |
tested |
T429 |
721-727 |
IN |
denotes |
except |
T430 |
728-731 |
IN |
denotes |
for |
T431 |
732-737 |
NN |
denotes |
Acdp1 |
T432 |
737-739 |
, |
denotes |
, |
T433 |
739-744 |
WDT |
denotes |
which |
T434 |
760-769 |
VBN |
denotes |
expressed |
T435 |
745-747 |
VBZ |
denotes |
is |
T436 |
748-752 |
RB |
denotes |
only |
T437 |
753-759 |
RB |
denotes |
highly |
T438 |
770-772 |
IN |
denotes |
in |
T439 |
773-776 |
DT |
denotes |
the |
T440 |
777-782 |
NN |
denotes |
brain |
T441 |
783-787 |
IN |
denotes |
with |
T442 |
792-798 |
NNS |
denotes |
levels |
T443 |
788-791 |
JJ |
denotes |
low |
T444 |
799-801 |
IN |
denotes |
of |
T445 |
802-812 |
NN |
denotes |
expression |
T446 |
813-815 |
IN |
denotes |
in |
T447 |
816-822 |
NN |
denotes |
kidney |
T448 |
823-826 |
CC |
denotes |
and |
T449 |
827-833 |
NN |
denotes |
testis |
T450 |
833-834 |
. |
denotes |
. |
T451 |
834-941 |
sentence |
denotes |
Immunostaining of Acdp1 in hippocampus neurons revealed a predominant localization on the plasma membrane. |
T452 |
835-849 |
NN |
denotes |
Immunostaining |
T453 |
882-890 |
VBD |
denotes |
revealed |
T454 |
850-852 |
IN |
denotes |
of |
T455 |
853-858 |
NN |
denotes |
Acdp1 |
T456 |
859-861 |
IN |
denotes |
in |
T457 |
862-873 |
NN |
denotes |
hippocampus |
T458 |
874-881 |
NNS |
denotes |
neurons |
T459 |
891-892 |
DT |
denotes |
a |
T460 |
905-917 |
NN |
denotes |
localization |
T461 |
893-904 |
JJ |
denotes |
predominant |
T462 |
918-920 |
IN |
denotes |
on |
T463 |
921-924 |
DT |
denotes |
the |
T464 |
932-940 |
NN |
denotes |
membrane |
T465 |
925-931 |
NN |
denotes |
plasma |
T466 |
940-941 |
. |
denotes |
. |
R58 |
T284 |
T285 |
det |
The,genes |
R59 |
T285 |
T288 |
nsubj |
genes,contain |
R60 |
T286 |
T285 |
nummod |
four,genes |
R61 |
T287 |
T285 |
compound |
Acdp,genes |
R62 |
T289 |
T285 |
punct |
(,genes |
R63 |
T290 |
T285 |
appos |
Acdp1,genes |
R64 |
T291 |
T290 |
punct |
", ",Acdp1 |
R65 |
T292 |
T290 |
conj |
Acdp2,Acdp1 |
R66 |
T293 |
T292 |
punct |
", ",Acdp2 |
R67 |
T294 |
T292 |
conj |
Acdp3,Acdp2 |
R68 |
T295 |
T294 |
cc |
and,Acdp3 |
R69 |
T296 |
T294 |
conj |
Acdp4,Acdp3 |
R70 |
T297 |
T288 |
punct |
),contain |
R71 |
T298 |
T299 |
nummod |
"3,631",bp |
R72 |
T299 |
T288 |
dobj |
bp,contain |
R73 |
T300 |
T299 |
punct |
", ",bp |
R74 |
T301 |
T302 |
nummod |
"3,244",bp |
R75 |
T302 |
T299 |
conj |
bp,bp |
R76 |
T303 |
T302 |
punct |
", ",bp |
R77 |
T304 |
T305 |
nummod |
"2,684",bp |
R78 |
T305 |
T302 |
conj |
bp,bp |
R79 |
T306 |
T305 |
cc |
and,bp |
R80 |
T307 |
T308 |
nummod |
"2,743",bp |
R81 |
T308 |
T305 |
conj |
bp,bp |
R82 |
T309 |
T299 |
prep |
of,bp |
R83 |
T310 |
T311 |
compound |
cDNA,sequences |
R84 |
T311 |
T309 |
pobj |
sequences,of |
R85 |
T312 |
T288 |
punct |
", ",contain |
R86 |
T313 |
T288 |
cc |
and,contain |
R87 |
T314 |
T288 |
conj |
encode,contain |
R88 |
T315 |
T316 |
amod |
deduced,proteins |
R89 |
T316 |
T314 |
dobj |
proteins,encode |
R90 |
T317 |
T316 |
prep |
of,proteins |
R91 |
T318 |
T319 |
nummod |
951,acids |
R92 |
T319 |
T317 |
pobj |
acids,of |
R93 |
T320 |
T318 |
punct |
", ",951 |
R94 |
T321 |
T318 |
conj |
874,951 |
R95 |
T322 |
T321 |
punct |
", ",874 |
R96 |
T323 |
T321 |
conj |
713,874 |
R97 |
T324 |
T323 |
cc |
and,713 |
R98 |
T325 |
T323 |
conj |
771,713 |
R99 |
T326 |
T319 |
compound |
amino,acids |
R100 |
T327 |
T314 |
punct |
", ",encode |
R101 |
T328 |
T314 |
advmod |
respectively,encode |
R102 |
T329 |
T288 |
punct |
.,contain |
R103 |
T331 |
T332 |
det |
The,genes |
R104 |
T332 |
T335 |
nsubj |
genes,showed |
R105 |
T333 |
T332 |
compound |
mouse,genes |
R106 |
T334 |
T332 |
compound |
Acdp,genes |
R107 |
T336 |
T337 |
advmod |
very,strong |
R108 |
T337 |
T338 |
amod |
strong,homologies |
R109 |
T338 |
T335 |
dobj |
homologies,showed |
R110 |
T339 |
T340 |
punct |
(,% |
R111 |
T340 |
T338 |
parataxis |
%,homologies |
R112 |
T341 |
T342 |
punct |
>,90 |
R113 |
T342 |
T340 |
nummod |
90,% |
R114 |
T343 |
T340 |
punct |
),% |
R115 |
T344 |
T338 |
prep |
in,homologies |
R116 |
T345 |
T346 |
preconj |
both,nucleotide |
R117 |
T346 |
T347 |
nmod |
nucleotide,sequences |
R118 |
T347 |
T344 |
pobj |
sequences,in |
R119 |
T348 |
T346 |
cc |
and,nucleotide |
R120 |
T349 |
T350 |
compound |
amino,acid |
R121 |
T350 |
T346 |
conj |
acid,nucleotide |
R122 |
T351 |
T338 |
prep |
to,homologies |
R123 |
T352 |
T353 |
poss |
their,counterparts |
R125 |
T354 |
T353 |
amod |
human,counterparts |
R126 |
T355 |
T335 |
punct |
.,showed |
R127 |
T357 |
T358 |
prep |
In,conserved |
R128 |
T359 |
T357 |
pobj |
addition,In |
R129 |
T360 |
T358 |
punct |
", ",conserved |
R130 |
T361 |
T362 |
preconj |
both,nucleotide |
R131 |
T362 |
T363 |
nmod |
nucleotide,sequences |
R132 |
T363 |
T358 |
nsubjpass |
sequences,conserved |
R133 |
T364 |
T362 |
cc |
and,nucleotide |
R134 |
T365 |
T366 |
compound |
amino,acid |
R135 |
T366 |
T362 |
conj |
acid,nucleotide |
R136 |
T367 |
T363 |
prep |
within,sequences |
R137 |
T368 |
T369 |
det |
the,Domain |
R138 |
T369 |
T367 |
pobj |
Domain,within |
R139 |
T370 |
T369 |
amod |
Ancient,Domain |
R140 |
T371 |
T369 |
amod |
Conserved,Domain |
R141 |
T372 |
T369 |
punct |
(,Domain |
R142 |
T373 |
T369 |
appos |
ACD,Domain |
R143 |
T374 |
T358 |
punct |
),conserved |
R144 |
T375 |
T358 |
auxpass |
are,conserved |
R145 |
T376 |
T358 |
advmod |
highly,conserved |
R146 |
T377 |
T358 |
prep |
in,conserved |
R147 |
T378 |
T379 |
amod |
many,species |
R148 |
T379 |
T377 |
pobj |
species,in |
R149 |
T380 |
T379 |
amod |
different,species |
R150 |
T381 |
T379 |
amod |
taxonomic,species |
R151 |
T382 |
T358 |
punct |
.,conserved |
R152 |
T384 |
T385 |
advmod |
Particularly,showed |
R153 |
T386 |
T385 |
punct |
", ",showed |
R154 |
T387 |
T388 |
compound |
Acdp,proteins |
R155 |
T388 |
T385 |
nsubj |
proteins,showed |
R156 |
T389 |
T390 |
advmod |
very,strong |
R157 |
T390 |
T391 |
amod |
strong,homologies |
R159 |
T392 |
T391 |
compound |
AA,homologies |
R160 |
T393 |
T391 |
prep |
to,homologies |
R161 |
T394 |
T395 |
det |
the,protein |
R162 |
T395 |
T393 |
pobj |
protein,to |
R163 |
T396 |
T395 |
compound |
bacteria,protein |
R164 |
T397 |
T395 |
compound |
CorC,protein |
R165 |
T398 |
T399 |
punct |
(,identity |
R166 |
T399 |
T395 |
parataxis |
identity,protein |
R167 |
T400 |
T401 |
nummod |
35,% |
R168 |
T401 |
T399 |
compound |
%,identity |
R169 |
T402 |
T399 |
compound |
AA,identity |
R170 |
T403 |
T399 |
prep |
with,identity |
R171 |
T404 |
T405 |
nummod |
55,% |
R172 |
T405 |
T406 |
compound |
%,homology |
R173 |
T406 |
T403 |
pobj |
homology,with |
R174 |
T407 |
T399 |
punct |
),identity |
R175 |
T408 |
T395 |
punct |
", ",protein |
R176 |
T409 |
T410 |
dep |
which,involved |
R178 |
T411 |
T410 |
auxpass |
is,involved |
R179 |
T412 |
T410 |
prep |
in,involved |
R180 |
T413 |
T414 |
nmod |
magnesium,efflux |
R181 |
T414 |
T412 |
pobj |
efflux,in |
R182 |
T415 |
T413 |
cc |
and,magnesium |
R183 |
T416 |
T413 |
conj |
cobalt,magnesium |
R184 |
T417 |
T385 |
punct |
.,showed |
R185 |
T419 |
T420 |
det |
The,genes |
R187 |
T421 |
T420 |
compound |
Acdp,genes |
R188 |
T423 |
T422 |
auxpass |
are,expressed |
R189 |
T424 |
T422 |
advmod |
widely,expressed |
R190 |
T425 |
T422 |
prep |
in,expressed |
R191 |
T426 |
T427 |
det |
all,tissues |
R192 |
T427 |
T425 |
pobj |
tissues,in |
R193 |
T428 |
T427 |
acl |
tested,tissues |
R194 |
T429 |
T422 |
prep |
except,expressed |
R195 |
T430 |
T429 |
prep |
for,except |
R196 |
T431 |
T430 |
pobj |
Acdp1,for |
R197 |
T432 |
T431 |
punct |
", ",Acdp1 |
R198 |
T433 |
T434 |
dep |
which,expressed |
R199 |
T434 |
T431 |
relcl |
expressed,Acdp1 |
R200 |
T435 |
T434 |
auxpass |
is,expressed |
R201 |
T436 |
T434 |
advmod |
only,expressed |
R202 |
T437 |
T434 |
advmod |
highly,expressed |
R203 |
T438 |
T434 |
prep |
in,expressed |
R204 |
T439 |
T440 |
det |
the,brain |
R205 |
T440 |
T438 |
pobj |
brain,in |
R206 |
T441 |
T442 |
mark |
with,levels |
R208 |
T443 |
T442 |
amod |
low,levels |
R209 |
T444 |
T442 |
prep |
of,levels |
R210 |
T445 |
T444 |
pobj |
expression,of |
R211 |
T446 |
T442 |
prep |
in,levels |
R212 |
T447 |
T446 |
pobj |
kidney,in |
R213 |
T448 |
T447 |
cc |
and,kidney |
R214 |
T449 |
T447 |
conj |
testis,kidney |
R215 |
T450 |
T422 |
punct |
.,expressed |
R216 |
T452 |
T453 |
nsubj |
Immunostaining,revealed |
R217 |
T454 |
T452 |
prep |
of,Immunostaining |
R218 |
T455 |
T454 |
pobj |
Acdp1,of |
R219 |
T456 |
T455 |
prep |
in,Acdp1 |
R220 |
T457 |
T458 |
compound |
hippocampus,neurons |
R221 |
T458 |
T456 |
pobj |
neurons,in |
R222 |
T459 |
T460 |
det |
a,localization |
R224 |
T461 |
T460 |
amod |
predominant,localization |
R225 |
T462 |
T453 |
prep |
on,revealed |
R226 |
T463 |
T464 |
det |
the,membrane |
R228 |
T465 |
T464 |
compound |
plasma,membrane |
R229 |
T466 |
T453 |
punct |
.,revealed |
R124 |
T353 |
T351 |
pobj |
counterparts,to |
R158 |
T391 |
T385 |
dobj |
homologies,showed |
R177 |
T410 |
T395 |
relcl |
involved,protein |
R186 |
T420 |
T422 |
nsubjpass |
genes,expressed |
R207 |
T442 |
T434 |
advcl |
levels,expressed |
R223 |
T460 |
T453 |
dobj |
localization,revealed |
R227 |
T464 |
T462 |
pobj |
membrane,on |