Id |
Subject |
Object |
Predicate |
Lexical cue |
T282 |
0-7 |
NNS |
denotes |
Results |
T283 |
7-208 |
sentence |
denotes |
The four Acdp genes (Acdp1, Acdp2, Acdp3 and Acdp4) contain 3,631 bp, 3,244 bp, 2,684 bp and 2,743 bp of cDNA sequences, and encode deduced proteins of 951, 874, 713 and 771 amino acids, respectively. |
T284 |
8-11 |
DT |
denotes |
The |
T285 |
22-27 |
NNS |
denotes |
genes |
T286 |
12-16 |
CD |
denotes |
four |
T287 |
17-21 |
NN |
denotes |
Acdp |
T288 |
60-67 |
VBP |
denotes |
contain |
T289 |
28-29 |
-LRB- |
denotes |
( |
T290 |
29-34 |
NN |
denotes |
Acdp1 |
T291 |
34-36 |
, |
denotes |
, |
T292 |
36-41 |
NN |
denotes |
Acdp2 |
T293 |
41-43 |
, |
denotes |
, |
T294 |
43-48 |
NN |
denotes |
Acdp3 |
T295 |
49-52 |
CC |
denotes |
and |
T296 |
53-58 |
NN |
denotes |
Acdp4 |
T297 |
58-59 |
-RRB- |
denotes |
) |
T298 |
68-73 |
CD |
denotes |
3,631 |
T299 |
74-76 |
NNS |
denotes |
bp |
T300 |
76-78 |
, |
denotes |
, |
T301 |
78-83 |
CD |
denotes |
3,244 |
T302 |
84-86 |
NNS |
denotes |
bp |
T303 |
86-88 |
, |
denotes |
, |
T304 |
88-93 |
CD |
denotes |
2,684 |
T305 |
94-96 |
NNS |
denotes |
bp |
T306 |
97-100 |
CC |
denotes |
and |
T307 |
101-106 |
CD |
denotes |
2,743 |
T308 |
107-109 |
NNS |
denotes |
bp |
T309 |
110-112 |
IN |
denotes |
of |
T310 |
113-117 |
NN |
denotes |
cDNA |
T311 |
118-127 |
NNS |
denotes |
sequences |
T312 |
127-129 |
, |
denotes |
, |
T313 |
129-132 |
CC |
denotes |
and |
T314 |
133-139 |
VBP |
denotes |
encode |
T315 |
140-147 |
VBN |
denotes |
deduced |
T316 |
148-156 |
NN |
denotes |
proteins |
T317 |
157-159 |
IN |
denotes |
of |
T318 |
160-163 |
CD |
denotes |
951 |
T319 |
188-193 |
NNS |
denotes |
acids |
T320 |
163-165 |
, |
denotes |
, |
T321 |
165-168 |
CD |
denotes |
874 |
T322 |
168-170 |
, |
denotes |
, |
T323 |
170-173 |
CD |
denotes |
713 |
T324 |
174-177 |
CC |
denotes |
and |
T325 |
178-181 |
CD |
denotes |
771 |
T326 |
182-187 |
NN |
denotes |
amino |
T327 |
193-195 |
, |
denotes |
, |
T328 |
195-207 |
RB |
denotes |
respectively |
T329 |
207-208 |
. |
denotes |
. |
T330 |
208-339 |
sentence |
denotes |
The mouse Acdp genes showed very strong homologies (>90%) in both nucleotide and amino acid sequences to their human counterparts. |
T331 |
209-212 |
DT |
denotes |
The |
T332 |
224-229 |
NNS |
denotes |
genes |
T333 |
213-218 |
NN |
denotes |
mouse |
T334 |
219-223 |
NN |
denotes |
Acdp |
T335 |
230-236 |
VBD |
denotes |
showed |
T336 |
237-241 |
RB |
denotes |
very |
T337 |
242-248 |
JJ |
denotes |
strong |
T338 |
249-259 |
NNS |
denotes |
homologies |
T339 |
260-261 |
-LRB- |
denotes |
( |
T340 |
264-265 |
NN |
denotes |
% |
T341 |
261-262 |
SYM |
denotes |
> |
T342 |
262-264 |
CD |
denotes |
90 |
T343 |
265-266 |
-RRB- |
denotes |
) |
T344 |
267-269 |
IN |
denotes |
in |
T345 |
270-274 |
CC |
denotes |
both |
T346 |
275-285 |
NN |
denotes |
nucleotide |
T347 |
301-310 |
NNS |
denotes |
sequences |
T348 |
286-289 |
CC |
denotes |
and |
T349 |
290-295 |
NN |
denotes |
amino |
T350 |
296-300 |
NN |
denotes |
acid |
T351 |
311-313 |
IN |
denotes |
to |
T352 |
314-319 |
PRP$ |
denotes |
their |
T353 |
326-338 |
NNS |
denotes |
counterparts |
T354 |
320-325 |
JJ |
denotes |
human |
T355 |
338-339 |
. |
denotes |
. |
T356 |
339-493 |
sentence |
denotes |
In addition, both nucleotide and amino acid sequences within the Ancient Conserved Domain (ACD) are highly conserved in many different taxonomic species. |
T357 |
340-342 |
IN |
denotes |
In |
T358 |
447-456 |
VBN |
denotes |
conserved |
T359 |
343-351 |
NN |
denotes |
addition |
T360 |
351-353 |
, |
denotes |
, |
T361 |
353-357 |
CC |
denotes |
both |
T362 |
358-368 |
NN |
denotes |
nucleotide |
T363 |
384-393 |
NNS |
denotes |
sequences |
T364 |
369-372 |
CC |
denotes |
and |
T365 |
373-378 |
NN |
denotes |
amino |
T366 |
379-383 |
NN |
denotes |
acid |
T367 |
394-400 |
IN |
denotes |
within |
T368 |
401-404 |
DT |
denotes |
the |
T369 |
423-429 |
NN |
denotes |
Domain |
T370 |
405-412 |
JJ |
denotes |
Ancient |
T371 |
413-422 |
VBN |
denotes |
Conserved |
T372 |
430-431 |
-LRB- |
denotes |
( |
T373 |
431-434 |
NN |
denotes |
ACD |
T374 |
434-435 |
-RRB- |
denotes |
) |
T375 |
436-439 |
VBP |
denotes |
are |
T376 |
440-446 |
RB |
denotes |
highly |
T377 |
457-459 |
IN |
denotes |
in |
T378 |
460-464 |
JJ |
denotes |
many |
T379 |
485-492 |
NNS |
denotes |
species |
T380 |
465-474 |
JJ |
denotes |
different |
T381 |
475-484 |
JJ |
denotes |
taxonomic |
T382 |
492-493 |
. |
denotes |
. |
T383 |
493-670 |
sentence |
denotes |
Particularly, Acdp proteins showed very strong AA homologies to the bacteria CorC protein (35% AA identity with 55% homology), which is involved in magnesium and cobalt efflux. |
T384 |
494-506 |
RB |
denotes |
Particularly |
T385 |
522-528 |
VBD |
denotes |
showed |
T386 |
506-508 |
, |
denotes |
, |
T387 |
508-512 |
NN |
denotes |
Acdp |
T388 |
513-521 |
NN |
denotes |
proteins |
T389 |
529-533 |
RB |
denotes |
very |
T390 |
534-540 |
JJ |
denotes |
strong |
T391 |
544-554 |
NNS |
denotes |
homologies |
T392 |
541-543 |
NN |
denotes |
AA |
T393 |
555-557 |
IN |
denotes |
to |
T394 |
558-561 |
DT |
denotes |
the |
T395 |
576-583 |
NN |
denotes |
protein |
T396 |
562-570 |
NNS |
denotes |
bacteria |
T397 |
571-575 |
NN |
denotes |
CorC |
T398 |
584-585 |
-LRB- |
denotes |
( |
T399 |
592-600 |
NN |
denotes |
identity |
T400 |
585-587 |
CD |
denotes |
35 |
T401 |
587-588 |
NN |
denotes |
% |
T402 |
589-591 |
NN |
denotes |
AA |
T403 |
601-605 |
IN |
denotes |
with |
T404 |
606-608 |
CD |
denotes |
55 |
T405 |
608-609 |
NN |
denotes |
% |
T406 |
610-618 |
NN |
denotes |
homology |
T407 |
618-619 |
-RRB- |
denotes |
) |
T408 |
619-621 |
, |
denotes |
, |
T409 |
621-626 |
WDT |
denotes |
which |
T410 |
630-638 |
VBN |
denotes |
involved |
T411 |
627-629 |
VBZ |
denotes |
is |
T412 |
639-641 |
IN |
denotes |
in |
T413 |
642-651 |
NN |
denotes |
magnesium |
T414 |
663-669 |
NN |
denotes |
efflux |
T415 |
652-655 |
CC |
denotes |
and |
T416 |
656-662 |
NN |
denotes |
cobalt |
T417 |
669-670 |
. |
denotes |
. |
T418 |
670-842 |
sentence |
denotes |
The Acdp genes are widely expressed in all tissues tested except for Acdp1, which is only highly expressed in the brain with low levels of expression in kidney and testis. |
T419 |
671-674 |
DT |
denotes |
The |
T420 |
680-685 |
NNS |
denotes |
genes |
T421 |
675-679 |
NN |
denotes |
Acdp |
T422 |
697-706 |
VBN |
denotes |
expressed |
T423 |
686-689 |
VBP |
denotes |
are |
T424 |
690-696 |
RB |
denotes |
widely |
T425 |
707-709 |
IN |
denotes |
in |
T426 |
710-713 |
DT |
denotes |
all |
T427 |
714-721 |
NNS |
denotes |
tissues |
T428 |
722-728 |
VBN |
denotes |
tested |
T429 |
729-735 |
IN |
denotes |
except |
T430 |
736-739 |
IN |
denotes |
for |
T431 |
740-745 |
NN |
denotes |
Acdp1 |
T432 |
745-747 |
, |
denotes |
, |
T433 |
747-752 |
WDT |
denotes |
which |
T434 |
768-777 |
VBN |
denotes |
expressed |
T435 |
753-755 |
VBZ |
denotes |
is |
T436 |
756-760 |
RB |
denotes |
only |
T437 |
761-767 |
RB |
denotes |
highly |
T438 |
778-780 |
IN |
denotes |
in |
T439 |
781-784 |
DT |
denotes |
the |
T440 |
785-790 |
NN |
denotes |
brain |
T441 |
791-795 |
IN |
denotes |
with |
T442 |
800-806 |
NNS |
denotes |
levels |
T443 |
796-799 |
JJ |
denotes |
low |
T444 |
807-809 |
IN |
denotes |
of |
T445 |
810-820 |
NN |
denotes |
expression |
T446 |
821-823 |
IN |
denotes |
in |
T447 |
824-830 |
NN |
denotes |
kidney |
T448 |
831-834 |
CC |
denotes |
and |
T449 |
835-841 |
NN |
denotes |
testis |
T450 |
841-842 |
. |
denotes |
. |
T451 |
842-949 |
sentence |
denotes |
Immunostaining of Acdp1 in hippocampus neurons revealed a predominant localization on the plasma membrane. |
T452 |
843-857 |
NN |
denotes |
Immunostaining |
T453 |
890-898 |
VBD |
denotes |
revealed |
T454 |
858-860 |
IN |
denotes |
of |
T455 |
861-866 |
NN |
denotes |
Acdp1 |
T456 |
867-869 |
IN |
denotes |
in |
T457 |
870-881 |
NN |
denotes |
hippocampus |
T458 |
882-889 |
NNS |
denotes |
neurons |
T459 |
899-900 |
DT |
denotes |
a |
T460 |
913-925 |
NN |
denotes |
localization |
T461 |
901-912 |
JJ |
denotes |
predominant |
T462 |
926-928 |
IN |
denotes |
on |
T463 |
929-932 |
DT |
denotes |
the |
T464 |
940-948 |
NN |
denotes |
membrane |
T465 |
933-939 |
NN |
denotes |
plasma |
T466 |
948-949 |
. |
denotes |
. |
R58 |
T284 |
T285 |
det |
The,genes |
R59 |
T285 |
T288 |
nsubj |
genes,contain |
R60 |
T286 |
T285 |
nummod |
four,genes |
R61 |
T287 |
T285 |
compound |
Acdp,genes |
R62 |
T289 |
T285 |
punct |
(,genes |
R63 |
T290 |
T285 |
appos |
Acdp1,genes |
R64 |
T291 |
T290 |
punct |
", ",Acdp1 |
R65 |
T292 |
T290 |
conj |
Acdp2,Acdp1 |
R66 |
T293 |
T292 |
punct |
", ",Acdp2 |
R67 |
T294 |
T292 |
conj |
Acdp3,Acdp2 |
R68 |
T295 |
T294 |
cc |
and,Acdp3 |
R69 |
T296 |
T294 |
conj |
Acdp4,Acdp3 |
R70 |
T297 |
T288 |
punct |
),contain |
R71 |
T298 |
T299 |
nummod |
"3,631",bp |
R72 |
T299 |
T288 |
dobj |
bp,contain |
R73 |
T300 |
T299 |
punct |
", ",bp |
R74 |
T301 |
T302 |
nummod |
"3,244",bp |
R75 |
T302 |
T299 |
conj |
bp,bp |
R76 |
T303 |
T302 |
punct |
", ",bp |
R77 |
T304 |
T305 |
nummod |
"2,684",bp |
R78 |
T305 |
T302 |
conj |
bp,bp |
R79 |
T306 |
T305 |
cc |
and,bp |
R80 |
T307 |
T308 |
nummod |
"2,743",bp |
R81 |
T308 |
T305 |
conj |
bp,bp |
R82 |
T309 |
T299 |
prep |
of,bp |
R83 |
T310 |
T311 |
compound |
cDNA,sequences |
R84 |
T311 |
T309 |
pobj |
sequences,of |
R85 |
T312 |
T288 |
punct |
", ",contain |
R86 |
T313 |
T288 |
cc |
and,contain |
R87 |
T314 |
T288 |
conj |
encode,contain |
R88 |
T315 |
T316 |
amod |
deduced,proteins |
R89 |
T316 |
T314 |
dobj |
proteins,encode |
R90 |
T317 |
T316 |
prep |
of,proteins |
R91 |
T318 |
T319 |
nummod |
951,acids |
R92 |
T319 |
T317 |
pobj |
acids,of |
R93 |
T320 |
T318 |
punct |
", ",951 |
R94 |
T321 |
T318 |
conj |
874,951 |
R95 |
T322 |
T321 |
punct |
", ",874 |
R96 |
T323 |
T321 |
conj |
713,874 |
R97 |
T324 |
T323 |
cc |
and,713 |
R98 |
T325 |
T323 |
conj |
771,713 |
R99 |
T326 |
T319 |
compound |
amino,acids |
R100 |
T327 |
T314 |
punct |
", ",encode |
R101 |
T328 |
T314 |
advmod |
respectively,encode |
R102 |
T329 |
T288 |
punct |
.,contain |
R103 |
T331 |
T332 |
det |
The,genes |
R104 |
T332 |
T335 |
nsubj |
genes,showed |
R105 |
T333 |
T332 |
compound |
mouse,genes |
R106 |
T334 |
T332 |
compound |
Acdp,genes |
R107 |
T336 |
T337 |
advmod |
very,strong |
R108 |
T337 |
T338 |
amod |
strong,homologies |
R109 |
T338 |
T335 |
dobj |
homologies,showed |
R110 |
T339 |
T340 |
punct |
(,% |
R111 |
T340 |
T338 |
parataxis |
%,homologies |
R112 |
T341 |
T342 |
punct |
>,90 |
R113 |
T342 |
T340 |
nummod |
90,% |
R114 |
T343 |
T340 |
punct |
),% |
R115 |
T344 |
T338 |
prep |
in,homologies |
R116 |
T345 |
T346 |
preconj |
both,nucleotide |
R117 |
T346 |
T347 |
nmod |
nucleotide,sequences |
R118 |
T347 |
T344 |
pobj |
sequences,in |
R119 |
T348 |
T346 |
cc |
and,nucleotide |
R120 |
T349 |
T350 |
compound |
amino,acid |
R121 |
T350 |
T346 |
conj |
acid,nucleotide |
R122 |
T351 |
T338 |
prep |
to,homologies |
R123 |
T352 |
T353 |
poss |
their,counterparts |
R125 |
T354 |
T353 |
amod |
human,counterparts |
R126 |
T355 |
T335 |
punct |
.,showed |
R127 |
T357 |
T358 |
prep |
In,conserved |
R128 |
T359 |
T357 |
pobj |
addition,In |
R129 |
T360 |
T358 |
punct |
", ",conserved |
R130 |
T361 |
T362 |
preconj |
both,nucleotide |
R131 |
T362 |
T363 |
nmod |
nucleotide,sequences |
R132 |
T363 |
T358 |
nsubjpass |
sequences,conserved |
R133 |
T364 |
T362 |
cc |
and,nucleotide |
R134 |
T365 |
T366 |
compound |
amino,acid |
R135 |
T366 |
T362 |
conj |
acid,nucleotide |
R136 |
T367 |
T363 |
prep |
within,sequences |
R137 |
T368 |
T369 |
det |
the,Domain |
R138 |
T369 |
T367 |
pobj |
Domain,within |
R139 |
T370 |
T369 |
amod |
Ancient,Domain |
R140 |
T371 |
T369 |
amod |
Conserved,Domain |
R141 |
T372 |
T369 |
punct |
(,Domain |
R142 |
T373 |
T369 |
appos |
ACD,Domain |
R143 |
T374 |
T358 |
punct |
),conserved |
R144 |
T375 |
T358 |
auxpass |
are,conserved |
R145 |
T376 |
T358 |
advmod |
highly,conserved |
R146 |
T377 |
T358 |
prep |
in,conserved |
R147 |
T378 |
T379 |
amod |
many,species |
R148 |
T379 |
T377 |
pobj |
species,in |
R149 |
T380 |
T379 |
amod |
different,species |
R150 |
T381 |
T379 |
amod |
taxonomic,species |
R151 |
T382 |
T358 |
punct |
.,conserved |
R152 |
T384 |
T385 |
advmod |
Particularly,showed |
R153 |
T386 |
T385 |
punct |
", ",showed |
R154 |
T387 |
T388 |
compound |
Acdp,proteins |
R155 |
T388 |
T385 |
nsubj |
proteins,showed |
R156 |
T389 |
T390 |
advmod |
very,strong |
R157 |
T390 |
T391 |
amod |
strong,homologies |
R159 |
T392 |
T391 |
compound |
AA,homologies |
R160 |
T393 |
T391 |
prep |
to,homologies |
R161 |
T394 |
T395 |
det |
the,protein |
R162 |
T395 |
T393 |
pobj |
protein,to |
R163 |
T396 |
T395 |
compound |
bacteria,protein |
R164 |
T397 |
T395 |
compound |
CorC,protein |
R165 |
T398 |
T399 |
punct |
(,identity |
R166 |
T399 |
T395 |
parataxis |
identity,protein |
R167 |
T400 |
T401 |
nummod |
35,% |
R168 |
T401 |
T399 |
compound |
%,identity |
R169 |
T402 |
T399 |
compound |
AA,identity |
R170 |
T403 |
T399 |
prep |
with,identity |
R171 |
T404 |
T405 |
nummod |
55,% |
R172 |
T405 |
T406 |
compound |
%,homology |
R173 |
T406 |
T403 |
pobj |
homology,with |
R174 |
T407 |
T399 |
punct |
),identity |
R175 |
T408 |
T395 |
punct |
", ",protein |
R176 |
T409 |
T410 |
dep |
which,involved |
R178 |
T411 |
T410 |
auxpass |
is,involved |
R179 |
T412 |
T410 |
prep |
in,involved |
R180 |
T413 |
T414 |
nmod |
magnesium,efflux |
R181 |
T414 |
T412 |
pobj |
efflux,in |
R182 |
T415 |
T413 |
cc |
and,magnesium |
R183 |
T416 |
T413 |
conj |
cobalt,magnesium |
R184 |
T417 |
T385 |
punct |
.,showed |
R185 |
T419 |
T420 |
det |
The,genes |
R187 |
T421 |
T420 |
compound |
Acdp,genes |
R188 |
T423 |
T422 |
auxpass |
are,expressed |
R189 |
T424 |
T422 |
advmod |
widely,expressed |
R190 |
T425 |
T422 |
prep |
in,expressed |
R191 |
T426 |
T427 |
det |
all,tissues |
R192 |
T427 |
T425 |
pobj |
tissues,in |
R193 |
T428 |
T427 |
acl |
tested,tissues |
R194 |
T429 |
T422 |
prep |
except,expressed |
R195 |
T430 |
T429 |
prep |
for,except |
R196 |
T431 |
T430 |
pobj |
Acdp1,for |
R197 |
T432 |
T431 |
punct |
", ",Acdp1 |
R198 |
T433 |
T434 |
dep |
which,expressed |
R199 |
T434 |
T431 |
relcl |
expressed,Acdp1 |
R200 |
T435 |
T434 |
auxpass |
is,expressed |
R201 |
T436 |
T434 |
advmod |
only,expressed |
R202 |
T437 |
T434 |
advmod |
highly,expressed |
R203 |
T438 |
T434 |
prep |
in,expressed |
R204 |
T439 |
T440 |
det |
the,brain |
R205 |
T440 |
T438 |
pobj |
brain,in |
R206 |
T441 |
T442 |
mark |
with,levels |
R208 |
T443 |
T442 |
amod |
low,levels |
R209 |
T444 |
T442 |
prep |
of,levels |
R210 |
T445 |
T444 |
pobj |
expression,of |
R211 |
T446 |
T442 |
prep |
in,levels |
R212 |
T447 |
T446 |
pobj |
kidney,in |
R213 |
T448 |
T447 |
cc |
and,kidney |
R214 |
T449 |
T447 |
conj |
testis,kidney |
R215 |
T450 |
T422 |
punct |
.,expressed |
R216 |
T452 |
T453 |
nsubj |
Immunostaining,revealed |
R217 |
T454 |
T452 |
prep |
of,Immunostaining |
R218 |
T455 |
T454 |
pobj |
Acdp1,of |
R219 |
T456 |
T455 |
prep |
in,Acdp1 |
R220 |
T457 |
T458 |
compound |
hippocampus,neurons |
R221 |
T458 |
T456 |
pobj |
neurons,in |
R222 |
T459 |
T460 |
det |
a,localization |
R224 |
T461 |
T460 |
amod |
predominant,localization |
R225 |
T462 |
T453 |
prep |
on,revealed |
R226 |
T463 |
T464 |
det |
the,membrane |
R228 |
T465 |
T464 |
compound |
plasma,membrane |
R229 |
T466 |
T453 |
punct |
.,revealed |
R124 |
T353 |
T351 |
pobj |
counterparts,to |
R158 |
T391 |
T385 |
dobj |
homologies,showed |
R177 |
T410 |
T395 |
relcl |
involved,protein |
R186 |
T420 |
T422 |
nsubjpass |
genes,expressed |
R207 |
T442 |
T434 |
advcl |
levels,expressed |
R223 |
T460 |
T453 |
dobj |
localization,revealed |
R227 |
T464 |
T462 |
pobj |
membrane,on |