PMC:3359311 / 1957-5746 JSON TXT

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test2

Id	Subject	Object	Predicate	Lexical cue
T875	1181-1199	Protein	denotes	Interleukin-1 beta
T876	1201-1206	Protein	denotes	IL-1β
T877	1442-1451	Positive_regulation	denotes	induction
T878	1496-1500	Protein	denotes	IL-6
T879	1611-1616	Protein	denotes	IL-1β
T880	1620-1628	Gene_expression	denotes	produced
T881	2420-2428	Positive_regulation	denotes	triggers
T882	2432-2440	Positive_regulation	denotes	increase
T883	2454-2459	Protein	denotes	IL-1β
T884	2461-2465	Protein	denotes	IL-6
T885	2630-2642	Positive_regulation	denotes	upregulation
T886	2702-2707	Protein	denotes	IL-1β
T887	2708-2718	Gene_expression	denotes	expression
T888	2767-2772	Protein	denotes	IL-1β
T889	2836-2841	Protein	denotes	IL-1β
T890	2846-2855	Positive_regulation	denotes	increased
T891	3033-3037	Protein	denotes	IL1B
T892	3192-3201	Positive_regulation	denotes	increases
T893	3205-3210	Protein	denotes	IL-1β
T894	3211-3221	Gene_expression	denotes	expression
T895	3225-3234	Localization	denotes	secretion
T896	3487-3496	Positive_regulation	denotes	increases
T897	3497-3506	Localization	denotes	secretion
T898	3510-3515	Protein	denotes	IL-1β
T899	3516-3530	Positive_regulation	denotes	in response to
T900	3719-3724	Protein	denotes	IL-1β
R707	T876	T875	equivalentTo	IL-1β,Interleukin-1 beta
R708	T878	T877	themeOf	IL-6,induction
R709	T879	T880	themeOf	IL-1β,produced
R710	T882	T881	themeOf	increase,triggers
R711	T883	T882	themeOf	IL-1β,increase
R712	T884	T882	themeOf	IL-6,increase
R713	T886	T887	themeOf	IL-1β,expression
R714	T887	T885	themeOf	expression,upregulation
R715	T889	T890	themeOf	IL-1β,increased
R716	T893	T894	themeOf	IL-1β,expression
R717	T894	T892	themeOf	expression,increases
R718	T895	T892	themeOf	secretion,increases
R719	T897	T899	themeOf	secretion,in response to
R720	T897	T896	themeOf	secretion,increases
R721	T898	T897	themeOf	IL-1β,secretion

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T1641	1181-1199	P01584	denotes	Interleukin-1 beta
T1642	1201-1206	P01584	denotes	IL-1β
T1643	1496-1500	P05231	denotes	IL-6
T1644	1505-1509	P10145	denotes	IL-8
T1645	1611-1616	P01584	denotes	IL-1β
T1646	1687-1692	P01584	denotes	IL-1β
T1647	1698-1703	P01584	denotes	IL-1β
T1648	1950-1955	P01584	denotes	IL-1β
T1649	2454-2459	P01584	denotes	IL-1β
T1650	2461-2465	P05231	denotes	IL-6
T1651	2471-2475	P10145	denotes	IL-8
T1652	2702-2707	P01584	denotes	IL-1β
T1653	2767-2772	P01584	denotes	IL-1β
T1654	2836-2841	P01584	denotes	IL-1β
T1655	3033-3037	P01584	denotes	IL1B
T1656	3205-3210	P01584	denotes	IL-1β
T1657	3510-3515	P01584	denotes	IL-1β
T1658	3719-3724	P01584	denotes	IL-1β

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue
T904	1181-1199	Protein	denotes	Interleukin-1 beta
T905	1201-1206	Protein	denotes	IL-1β
T906	1496-1500	Protein	denotes	IL-6
T907	1611-1616	Protein	denotes	IL-1β
T908	2420-2428	Positive_regulation	denotes	triggers
T909	2420-2428	Positive_regulation	denotes	triggers
T910	2432-2440	Positive_regulation	denotes	increase
T911	2432-2440	Positive_regulation	denotes	increase
T912	2454-2459	Protein	denotes	IL-1β
T913	2461-2465	Protein	denotes	IL-6
T914	2608-2617	Regulation	denotes	important
T915	2702-2707	Protein	denotes	IL-1β
T916	2708-2718	Gene_expression	denotes	expression
T917	2767-2772	Protein	denotes	IL-1β
T918	2836-2841	Protein	denotes	IL-1β
T919	2846-2855	Positive_regulation	denotes	increased
T920	3033-3037	Protein	denotes	IL1B
T921	3192-3201	Positive_regulation	denotes	increases
T922	3192-3201	Positive_regulation	denotes	increases
T923	3205-3210	Protein	denotes	IL-1β
T924	3211-3221	Gene_expression	denotes	expression
T925	3225-3234	Localization	denotes	secretion
T926	3487-3496	Positive_regulation	denotes	increases
T927	3497-3506	Localization	denotes	secretion
T928	3510-3515	Protein	denotes	IL-1β
T929	3719-3724	Protein	denotes	IL-1β
R722	T905	T904	equivalentTo	IL-1β,Interleukin-1 beta
R723	T910	T908	themeOf	increase,triggers
R724	T911	T909	themeOf	increase,triggers
R725	T912	T911	themeOf	IL-1β,increase
R726	T913	T910	themeOf	IL-6,increase
R727	T915	T916	themeOf	IL-1β,expression
R728	T916	T914	themeOf	expression,important
R729	T918	T919	themeOf	IL-1β,increased
R730	T923	T924	themeOf	IL-1β,expression
R731	T923	T925	themeOf	IL-1β,secretion
R732	T924	T922	themeOf	expression,increases
R733	T925	T921	themeOf	secretion,increases
R734	T927	T926	themeOf	secretion,increases
R735	T928	T927	themeOf	IL-1β,secretion

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T2513	90-141	Protein	denotes	cystic fibrosis transmembrane conductance regulator
T2514	143-147	Protein	denotes	CFTR
T2515	882-886	Protein	denotes	CFTR
T2516	874-881	Negative_regulation	denotes	lacking
T2517	1181-1199	Protein	denotes	Interleukin-1 beta
T2518	1201-1206	Protein	denotes	IL-1β
T2519	1232-1240	Positive_regulation	denotes	mediator
T2520	1232-1240	Positive_regulation	denotes	mediator
T2521	1496-1500	Protein	denotes	IL-6
T2522	1505-1509	Protein	denotes	IL-8
T2523	1442-1451	Positive_regulation	denotes	induction
T2524	1442-1451	Positive_regulation	denotes	induction
T2525	1586-1591	Protein	denotes	NF-κB
T2526	1611-1616	Protein	denotes	IL-1β
T2527	1620-1628	Gene_expression	denotes	produced
T2528	1950-1955	Protein	denotes	IL-1β
T2529	1960-1969	Protein	denotes	pro-IL-18
T2530	2011-2020	Localization	denotes	secretion
T2531	2011-2020	Localization	denotes	secretion
T2532	2086-2103	Protein	denotes	NLRP1 [12], NLRP3
T2533	2454-2459	Protein	denotes	IL-1β
T2534	2461-2465	Protein	denotes	IL-6
T2535	2471-2475	Protein	denotes	IL-8
T2536	2432-2440	Positive_regulation	denotes	increase
T2537	2432-2440	Positive_regulation	denotes	increase
T2538	2432-2440	Positive_regulation	denotes	increase
T2539	2576-2581	Protein	denotes	NF-κB
T2540	2599-2604	Protein	denotes	NF-κB
T2541	2702-2707	Protein	denotes	IL-1β
T2542	2708-2718	Gene_expression	denotes	expression
T2543	2630-2642	Positive_regulation	denotes	upregulation
T2544	2767-2772	Protein	denotes	IL-1β
T2545	2836-2841	Protein	denotes	IL-1β
T2546	2846-2855	Positive_regulation	denotes	increased
T2547	3033-3042	Protein	denotes	IL1B gene
T2548	3148-3152	Protein	denotes	CFTR
T2549	3205-3210	Protein	denotes	IL-1β
T2550	3306-3310	Protein	denotes	CFTR
T2551	3321-3326	Protein	denotes	NF-κB
T2552	3211-3221	Gene_expression	denotes	expression
T2553	3298-3302	Negative_regulation	denotes	loss
T2554	3327-3337	Positive_regulation	denotes	activation
T2555	3192-3201	Positive_regulation	denotes	increases
T2556	3311-3320	Positive_regulation	denotes	increases
T2557	3510-3515	Protein	denotes	IL-1β
T2558	3531-3536	Protein	denotes	NLRP3
T2559	3645-3650	Protein	denotes	NLRP3
T2560	3497-3506	Localization	denotes	secretion
T2561	3651-3661	Positive_regulation	denotes	activation
T2562	3487-3496	Positive_regulation	denotes	increases
T2563	3719-3724	Protein	denotes	IL-1β
R2173	T2515	T2516	themeOf	CFTR,lacking
R2181	T2517	T2519	themeOf	Interleukin-1 beta,mediator
R2186	T2518	T2520	themeOf	IL-1β,mediator
R2189	T2521	T2523	themeOf	IL-6,induction
R2190	T2522	T2524	themeOf	IL-8,induction
R2191	T2526	T2527	themeOf	IL-1β,produced
R2192	T2528	T2530	themeOf	IL-1β,secretion
R2193	T2529	T2531	themeOf	pro-IL-18,secretion
R2194	T2533	T2536	themeOf	IL-1β,increase
R2195	T2534	T2537	themeOf	IL-6,increase
R2196	T2535	T2538	themeOf	IL-8,increase
R2197	T2541	T2542	themeOf	IL-1β,expression
R2198	T2542	T2543	themeOf	expression,upregulation
R2199	T2545	T2546	themeOf	IL-1β,increased
R2200	T2549	T2552	themeOf	IL-1β,expression
R2201	T2550	T2553	themeOf	CFTR,loss
R2202	T2551	T2554	themeOf	NF-κB,activation
R2203	T2552	T2555	themeOf	expression,increases
R2204	T2553	T2556	causeOf	loss,increases
R2205	T2554	T2556	themeOf	activation,increases
R2206	T2557	T2560	themeOf	IL-1β,secretion
R2207	T2559	T2561	themeOf	NLRP3,activation
R2208	T2560	T2562	themeOf	secretion,increases

events-check-again

Id	Subject	Object	Predicate	Lexical cue
T2487	1181-1199	Protein	denotes	Interleukin-1 beta
T2488	1201-1206	Protein	denotes	IL-1β
T2489	1496-1500	Protein	denotes	IL-6
T2490	1611-1616	Protein	denotes	IL-1β
T2491	2420-2428	Positive_regulation	denotes	triggers
T2492	2420-2428	Positive_regulation	denotes	triggers
T2493	2432-2440	Positive_regulation	denotes	increase
T2494	2432-2440	Positive_regulation	denotes	increase
T2495	2454-2459	Protein	denotes	IL-1β
T2496	2461-2465	Protein	denotes	IL-6
T2497	2608-2617	Regulation	denotes	important
T2498	2702-2707	Protein	denotes	IL-1β
T2499	2708-2718	Gene_expression	denotes	expression
T2500	2767-2772	Protein	denotes	IL-1β
T2501	2836-2841	Protein	denotes	IL-1β
T2502	2846-2855	Positive_regulation	denotes	increased
T2503	3033-3037	Protein	denotes	IL1B
T2504	3192-3201	Positive_regulation	denotes	increases
T2505	3192-3201	Positive_regulation	denotes	increases
T2506	3205-3210	Protein	denotes	IL-1β
T2507	3211-3221	Gene_expression	denotes	expression
T2508	3225-3234	Localization	denotes	secretion
T2509	3487-3496	Positive_regulation	denotes	increases
T2510	3497-3506	Localization	denotes	secretion
T2511	3510-3515	Protein	denotes	IL-1β
T2512	3719-3724	Protein	denotes	IL-1β
R2171	T2488	T2487	equivalentTo	IL-1β,Interleukin-1 beta
R2174	T2493	T2491	themeOf	increase,triggers
R2175	T2494	T2492	themeOf	increase,triggers
R2176	T2495	T2494	themeOf	IL-1β,increase
R2177	T2496	T2493	themeOf	IL-6,increase
R2178	T2498	T2499	themeOf	IL-1β,expression
R2179	T2499	T2497	themeOf	expression,important
R2180	T2501	T2502	themeOf	IL-1β,increased
R2182	T2506	T2507	themeOf	IL-1β,expression
R2183	T2506	T2508	themeOf	IL-1β,secretion
R2184	T2507	T2505	themeOf	expression,increases
R2185	T2508	T2504	themeOf	secretion,increases
R2187	T2510	T2509	themeOf	secretion,increases
R2188	T2511	T2510	themeOf	IL-1β,secretion

ICD10

Id	Subject	Object	Predicate	Lexical cue
T2419	90-105	http://purl.bioontology.org/ontology/ICD10/E84	denotes	cystic fibrosis
T2420	90-105	http://purl.bioontology.org/ontology/ICD10/E84.9	denotes	cystic fibrosis
T2421	1383-1388	http://purl.bioontology.org/ontology/ICD10/R50.9	denotes	fever

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T2422	106-119	http://purl.obolibrary.org/obo/GO_0016021	denotes	transmembrane
T2423	106-119	http://purl.obolibrary.org/obo/GO_0044214	denotes	transmembrane
T2424	601-605	http://purl.obolibrary.org/obo/GO_0018995	denotes	host
T2425	601-611	http://purl.obolibrary.org/obo/GO_0043657	denotes	host cells
T2426	606-611	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2427	684-689	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2428	868-873	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2429	1431-1436	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T2430	1532-1536	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T2431	3468-3472	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T2432	1636-1643	http://purl.obolibrary.org/obo/GO_0005829	denotes	cytosol
T2433	1764-1781	http://purl.obolibrary.org/obo/GO_0043234	denotes	protein complexes
T2434	3619-3632	http://purl.obolibrary.org/obo/GO_0005576	denotes	extracellular

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T2413	180-191	http://purl.obolibrary.org/obo/GO_0022831	denotes	ion channel
T2414	1496-1500	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T2415	2461-2465	http://purl.obolibrary.org/obo/GO_0005138	denotes	IL-6
T2416	1505-1509	http://purl.obolibrary.org/obo/GO_0005153	denotes	IL-8
T2417	2471-2475	http://purl.obolibrary.org/obo/GO_0005153	denotes	IL-8
T2418	1964-1969	http://purl.obolibrary.org/obo/GO_0045515	denotes	IL-18

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T2392	180-191	http://purl.obolibrary.org/obo/GO_0022831	denotes	ion channel
T2393	361-364	http://purl.obolibrary.org/obo/GO_0007568	denotes	age
T2394	486-491	http://purl.obolibrary.org/obo/GO_0016265	denotes	death
T2395	510-522	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T2396	830-851	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory response
T2397	749-766	http://purl.obolibrary.org/obo/GO_0034097	denotes	cytokine response
T2398	1181-1199	http://purl.obolibrary.org/obo/GO_0050720	denotes	Interleukin-1 beta
T2399	1181-1199	http://purl.obolibrary.org/obo/GO_0050702	denotes	Interleukin-1 beta
T2400	1193-1203	http://purl.obolibrary.org/obo/GO_0032611	denotes	1 beta (IL
T2401	1313-1325	http://purl.obolibrary.org/obo/GO_0009405	denotes	pathogenesis
T2402	2780-2792	http://purl.obolibrary.org/obo/GO_0009405	denotes	pathogenesis
T2403	1369-1388	http://purl.obolibrary.org/obo/GO_0001660	denotes	generation of fever
T2404	1592-1601	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2405	2582-2591	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T2406	1592-1609	http://purl.obolibrary.org/obo/GO_0007165	denotes	signaling cascade
T2407	1852-1860	http://purl.obolibrary.org/obo/GO_0007349	denotes	cellular
T2408	1897-1918	http://purl.obolibrary.org/obo/GO_0006919	denotes	activation of caspase
T2409	2011-2020	http://purl.obolibrary.org/obo/GO_0046903	denotes	secretion
T2410	3225-3234	http://purl.obolibrary.org/obo/GO_0046903	denotes	secretion
T2411	3497-3506	http://purl.obolibrary.org/obo/GO_0046903	denotes	secretion
T2412	3321-3337	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation

UBERON-AE

Id	Subject	Object	Predicate	Lexical cue
T901	445-449	http://purl.obolibrary.org/obo/UBERON_0002048	denotes	lung
T902	1329-1333	http://purl.obolibrary.org/obo/UBERON_0002048	denotes	lung
T903	2812-2816	http://purl.obolibrary.org/obo/UBERON_0002048	denotes	lung

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T1659	13-19	JJ	denotes	Cystic
T1660	20-28	NN	denotes	fibrosis
T1661	29-31	VBZ	denotes	is
T1662	32-34	DT	denotes	an
T1663	35-44	JJ	denotes	autosomal
T1664	45-54	JJ	denotes	recessive
T1665	55-62	NN	denotes	disease
T1666	63-69	VBN	denotes	caused
T1667	70-72	IN	denotes	by
T1668	73-82	NNS	denotes	mutations
T1669	83-85	IN	denotes	in
T1670	86-89	DT	denotes	the
T1671	90-96	JJ	denotes	cystic
T1672	97-105	NN	denotes	fibrosis
T1673	106-119	NN	denotes	transmembrane
T1674	120-131	NN	denotes	conductance
T1675	132-141	NN	denotes	regulator
T1676	142-143	-LRB-	denotes	(
T1677	143-147	NNP	denotes	CFTR
T1678	147-148	-RRB-	denotes	)
T1679	148-149	,	denotes	,
T1680	150-155	WDT	denotes	which
T1681	156-165	NNS	denotes	functions
T1682	166-168	IN	denotes	as
T1683	169-170	DT	denotes	a
T1684	171-179	NN	denotes	chloride
T1685	180-183	NN	denotes	ion
T1686	184-191	NN	denotes	channel
T1687	191-192	.	denotes	.
T1688	193-195	NN	denotes	CF
T1689	196-203	VBZ	denotes	remains
T1690	204-207	CD	denotes	one
T1691	208-210	IN	denotes	of
T1692	211-214	DT	denotes	the
T1693	215-219	RBS	denotes	most
T1694	220-226	JJ	denotes	common
T1695	227-233	JJ	denotes	lethal
T1696	234-241	JJ	denotes	genetic
T1697	242-250	NNS	denotes	diseases
T1698	251-253	IN	denotes	in
T1699	254-265	NNS	denotes	populations
T1700	266-268	IN	denotes	of
T1701	269-277	JJ	denotes	European
T1702	278-285	NN	denotes	descent
T1703	286-290	IN	denotes	with
T1704	291-294	DT	denotes	the
T1705	295-302	JJ	denotes	current
T1706	303-310	JJ	denotes	average
T1707	311-319	NN	denotes	lifespan
T1708	320-322	IN	denotes	of
T1709	323-325	NNP	denotes	CF
T1710	326-334	NNS	denotes	patients
T1711	335-348	RB	denotes	approximately
T1712	349-351	CD	denotes	40
T1713	352-357	NNS	denotes	years
T1714	358-360	IN	denotes	of
T1715	361-364	NN	denotes	age
T1716	365-366	NN	denotes	[
T1717	366-367	CD	denotes	1
T1718	367-368	NNP	denotes	]
T1719	368-369	,	denotes	,
T1720	370-371	NNP	denotes	[
T1721	371-372	CD	denotes	2
T1722	372-373	NNP	denotes	]
T1723	373-374	.	denotes	.
T1724	375-384	JJ	denotes	Recurrent
T1725	385-397	JJ	denotes	inflammatory
T1726	398-407	JJ	denotes	pulmonary
T1727	408-420	NN	denotes	exacerbation
T1728	421-423	VBZ	denotes	is
T1729	424-427	DT	denotes	the
T1730	428-435	JJ	denotes	primary
T1731	436-441	NN	denotes	cause
T1732	442-444	IN	denotes	of
T1733	445-449	NN	denotes	lung
T1734	450-457	NN	denotes	disease
T1735	458-469	NN	denotes	progression
T1736	470-473	CC	denotes	and
T1737	474-484	RB	denotes	ultimately
T1738	484-485	,	denotes	,
T1739	486-491	NN	denotes	death
T1740	492-494	IN	denotes	in
T1741	495-498	NNP	denotes	CF.
T1742	499-509	NNP	denotes	Controlled
T1743	510-522	NN	denotes	inflammation
T1744	523-525	VBZ	denotes	is
T1745	526-535	JJ	denotes	important
T1746	536-539	IN	denotes	for
T1747	540-548	VBG	denotes	fighting
T1748	549-558	NN	denotes	infection
T1749	558-559	,	denotes	,
T1750	560-563	CC	denotes	but
T1751	564-566	IN	denotes	in
T1752	567-573	JJ	denotes	excess
T1753	573-574	,	denotes	,
T1754	575-577	PRP	denotes	it
T1755	578-585	VBZ	denotes	becomes
T1756	586-597	JJ	denotes	destructive
T1757	598-600	TO	denotes	to
T1758	601-605	VB	denotes	host
T1759	606-611	NNS	denotes	cells
T1760	612-615	CC	denotes	and
T1761	616-618	TO	denotes	to
T1762	619-622	DT	denotes	the
T1763	623-635	NN	denotes	architecture
T1764	636-638	IN	denotes	of
T1765	639-642	DT	denotes	the
T1766	643-648	NNS	denotes	lungs
T1767	649-650	VBP	denotes	[
T1768	650-651	CD	denotes	2
T1769	651-652	NNP	denotes	]
T1770	652-653	,	denotes	,
T1771	654-655	NNP	denotes	[
T1772	655-656	CD	denotes	3
T1773	656-657	NNP	denotes	]
T1774	657-658	.	denotes	.
T1775	659-661	IN	denotes	In
T1776	662-664	NNP	denotes	CF
T1777	664-665	,	denotes	,
T1778	666-672	NN	denotes	airway
T1779	673-683	JJ	denotes	epithelial
T1780	684-689	NNS	denotes	cells
T1781	690-694	VBP	denotes	have
T1782	695-699	VBN	denotes	been
T1783	700-705	VBN	denotes	shown
T1784	706-708	TO	denotes	to
T1785	709-716	VB	denotes	produce
T1786	717-719	DT	denotes	an
T1787	720-731	JJ	denotes	exaggerated
T1788	732-748	JJ	denotes	pro-inflammatory
T1789	749-757	NN	denotes	cytokine
T1790	758-766	NN	denotes	response
T1791	767-769	TO	denotes	to
T1792	770-781	NN	denotes	stimulation
T1793	782-783	NN	denotes	[
T1794	783-784	CD	denotes	4
T1795	784-785	NNP	denotes	]
T1796	785-786	,	denotes	,
T1797	787-788	NNP	denotes	[
T1798	788-789	CD	denotes	5
T1799	789-790	NNP	denotes	]
T1800	790-791	.	denotes	.
T1801	792-794	PRP	denotes	It
T1802	795-797	VBZ	denotes	is
T1803	798-805	JJ	denotes	unclear
T1804	806-813	IN	denotes	whether
T1805	814-818	DT	denotes	this
T1806	819-829	VBN	denotes	heightened
T1807	830-842	JJ	denotes	inflammatory
T1808	843-851	NN	denotes	response
T1809	852-854	VBZ	denotes	is
T1810	855-864	JJ	denotes	intrinsic
T1811	865-867	TO	denotes	to
T1812	868-873	NNS	denotes	cells
T1813	874-881	VBG	denotes	lacking
T1814	882-886	NNP	denotes	CFTR
T1815	887-889	CC	denotes	or
T1816	890-897	IN	denotes	whether
T1817	898-900	PRP	denotes	it
T1818	901-903	VBZ	denotes	is
T1819	904-905	DT	denotes	a
T1820	906-912	NN	denotes	result
T1821	913-915	IN	denotes	of
T1822	916-923	JJ	denotes	chronic
T1823	924-937	JJ	denotes	polymicrobial
T1824	938-947	NN	denotes	infection
T1825	948-949	NN	denotes	[
T1826	949-950	CD	denotes	6
T1827	950-951	NNP	denotes	]
T1828	951-952	,	denotes	,
T1829	953-954	NNP	denotes	[
T1830	954-955	CD	denotes	7
T1831	955-956	NNP	denotes	]
T1832	956-957	.	denotes	.
T1833	958-968	RB	denotes	Regardless
T1834	969-971	IN	denotes	of
T1835	972-976	DT	denotes	this
T1836	977-988	NN	denotes	controversy
T1837	988-989	,	denotes	,
T1838	990-1001	VBG	denotes	identifying
T1839	1002-1005	CC	denotes	and
T1840	1006-1015	VBG	denotes	targeting
T1841	1016-1024	JJ	denotes	relevant
T1842	1025-1037	JJ	denotes	inflammatory
T1843	1038-1047	NNS	denotes	mediators
T1844	1048-1050	VBZ	denotes	is
T1845	1051-1052	DT	denotes	a
T1846	1053-1061	JJ	denotes	critical
T1847	1062-1066	NN	denotes	step
T1848	1067-1069	IN	denotes	in
T1849	1070-1080	VBG	denotes	developing
T1850	1081-1085	RBR	denotes	more
T1851	1086-1094	JJ	denotes	specific
T1852	1095-1106	JJ	denotes	therapeutic
T1853	1107-1117	NNS	denotes	approaches
T1854	1118-1120	TO	denotes	to
T1855	1121-1128	VB	denotes	control
T1856	1129-1141	NN	denotes	inflammation
T1857	1142-1145	CC	denotes	and
T1858	1146-1153	VB	denotes	improve
T1859	1154-1160	NN	denotes	health
T1860	1161-1169	NNS	denotes	outcomes
T1861	1170-1172	IN	denotes	in
T1862	1173-1175	NNP	denotes	CF
T1863	1176-1177	NNP	denotes	[
T1864	1177-1178	CD	denotes	8
T1865	1178-1179	NNP	denotes	]
T1866	1179-1180	.	denotes	.
T1867	1181-1194	NN	denotes	Interleukin-1
T1868	1195-1199	NN	denotes	beta
T1869	1200-1201	-LRB-	denotes	(
T1870	1201-1206	NN	denotes	IL-1β
T1871	1206-1207	-RRB-	denotes	)
T1872	1208-1210	VBZ	denotes	is
T1873	1211-1212	DT	denotes	a
T1874	1213-1218	JJ	denotes	major
T1875	1219-1231	JJ	denotes	inflammatory
T1876	1232-1240	NN	denotes	mediator
T1877	1240-1241	.	denotes	.
T1878	1242-1245	PRP$	denotes	Its
T1879	1246-1259	JJ	denotes	physiological
T1880	1260-1267	NNS	denotes	effects
T1881	1268-1271	VBP	denotes	are
T1882	1272-1279	JJ	denotes	diverse
T1883	1280-1283	CC	denotes	and
T1884	1284-1295	RB	denotes	potentially
T1885	1296-1305	JJ	denotes	important
T1886	1306-1308	TO	denotes	to
T1887	1309-1312	DT	denotes	the
T1888	1313-1325	NN	denotes	pathogenesis
T1889	1326-1328	IN	denotes	of
T1890	1329-1333	NN	denotes	lung
T1891	1334-1347	NNS	denotes	exacerbations
T1892	1348-1350	IN	denotes	in
T1893	1351-1353	NNP	denotes	CF
T1894	1353-1354	,	denotes	,
T1895	1355-1364	VBG	denotes	including
T1896	1365-1368	DT	denotes	the
T1897	1369-1379	NN	denotes	generation
T1898	1380-1382	IN	denotes	of
T1899	1383-1388	NN	denotes	fever
T1900	1388-1389	,	denotes	,
T1901	1390-1393	DT	denotes	the
T1902	1394-1405	NN	denotes	recruitment
T1903	1406-1408	IN	denotes	of
T1904	1409-1421	JJ	denotes	inflammatory
T1905	1422-1430	NN	denotes	effector
T1906	1431-1436	NNS	denotes	cells
T1907	1436-1437	,	denotes	,
T1908	1438-1441	DT	denotes	the
T1909	1442-1451	NN	denotes	induction
T1910	1452-1454	IN	denotes	of
T1911	1455-1460	JJ	denotes	other
T1912	1461-1477	JJ	denotes	pro-inflammatory
T1913	1478-1487	NNS	denotes	cytokines
T1914	1488-1492	JJ	denotes	such
T1915	1493-1495	IN	denotes	as
T1916	1496-1500	NNP	denotes	IL-6
T1917	1501-1504	CC	denotes	and
T1918	1505-1509	NNP	denotes	IL-8
T1919	1509-1510	,	denotes	,
T1920	1511-1514	CC	denotes	and
T1921	1515-1518	DT	denotes	the
T1922	1519-1526	VBG	denotes	shaping
T1923	1527-1529	IN	denotes	of
T1924	1530-1531	NNP	denotes	T
T1925	1532-1536	NN	denotes	cell
T1926	1537-1546	NNS	denotes	responses
T1927	1547-1548	VBP	denotes	[
T1928	1548-1549	CD	denotes	9
T1929	1549-1550	NNP	denotes	]
T1930	1550-1551	,	denotes	,
T1931	1552-1553	NNP	denotes	[
T1932	1553-1555	CD	denotes	10
T1933	1555-1556	NNP	denotes	]
T1934	1556-1557	.	denotes	.
T1935	1558-1567	VBG	denotes	Following
T1936	1568-1578	NN	denotes	initiation
T1937	1579-1581	IN	denotes	of
T1938	1582-1585	DT	denotes	the
T1939	1586-1591	NNP	denotes	NF-κB
T1940	1592-1601	VBG	denotes	signaling
T1941	1602-1609	NN	denotes	cascade
T1942	1609-1610	,	denotes	,
T1943	1611-1616	NN	denotes	IL-1β
T1944	1617-1619	VBZ	denotes	is
T1945	1620-1628	VBN	denotes	produced
T1946	1629-1631	IN	denotes	in
T1947	1632-1635	DT	denotes	the
T1948	1636-1643	NN	denotes	cytosol
T1949	1644-1646	IN	denotes	as
T1950	1647-1648	DT	denotes	a
T1951	1649-1661	RB	denotes	biologically
T1952	1662-1670	JJ	denotes	inactive
T1953	1671-1682	JJ	denotes	full-length
T1954	1683-1692	NN	denotes	pro-IL-1β
T1955	1692-1693	.	denotes	.
T1956	1694-1703	NNP	denotes	Pro-IL-1β
T1957	1704-1706	VBZ	denotes	is
T1958	1707-1719	RB	denotes	subsequently
T1959	1720-1729	VBN	denotes	converted
T1960	1730-1734	IN	denotes	into
T1961	1735-1738	PRP$	denotes	its
T1962	1739-1745	JJ	denotes	active
T1963	1746-1750	NN	denotes	form
T1964	1751-1753	IN	denotes	by
T1965	1754-1763	JJ	denotes	cytosolic
T1966	1764-1771	NN	denotes	protein
T1967	1772-1781	NNS	denotes	complexes
T1968	1782-1788	VBD	denotes	termed
T1969	1790-1803	NNS	denotes	inflammasomes
T1970	1803-1804	.	denotes	.
T1971	1806-1819	NNS	denotes	Inflammasomes
T1972	1820-1828	VBP	denotes	assemble
T1973	1829-1831	IN	denotes	in
T1974	1832-1840	NN	denotes	response
T1975	1841-1843	TO	denotes	to
T1976	1844-1851	JJ	denotes	certain
T1977	1852-1860	JJ	denotes	cellular
T1978	1861-1867	NN	denotes	danger
T1979	1868-1875	NNS	denotes	signals
T1980	1876-1879	CC	denotes	and
T1981	1880-1887	VB	denotes	mediate
T1982	1888-1891	DT	denotes	the
T1983	1892-1907	NN	denotes	auto-activation
T1984	1908-1910	IN	denotes	of
T1985	1911-1920	JJ	denotes	caspase-1
T1986	1921-1922	NN	denotes	[
T1987	1922-1923	CD	denotes	9
T1988	1923-1924	NNP	denotes	]
T1989	1924-1925	,	denotes	,
T1990	1926-1927	NNP	denotes	[
T1991	1927-1929	CD	denotes	11
T1992	1929-1930	NNP	denotes	]
T1993	1930-1931	,	denotes	,
T1994	1932-1937	WDT	denotes	which
T1995	1938-1945	VBZ	denotes	cleaves
T1996	1946-1955	NN	denotes	pro-IL-1β
T1997	1956-1959	CC	denotes	and
T1998	1960-1969	NN	denotes	pro-IL-18
T1999	1970-1974	IN	denotes	into
T2000	1975-1980	PRP$	denotes	their
T2001	1981-1993	RB	denotes	biologically
T2002	1994-2000	JJ	denotes	active
T2003	2001-2006	NNS	denotes	forms
T2004	2007-2010	IN	denotes	for
T2005	2011-2020	NN	denotes	secretion
T2006	2020-2021	.	denotes	.
T2007	2022-2026	CD	denotes	Four
T2008	2027-2035	JJ	denotes	distinct
T2009	2036-2049	NNS	denotes	inflammasomes
T2010	2050-2054	VBP	denotes	have
T2011	2055-2059	VBN	denotes	been
T2012	2060-2070	VBN	denotes	recognized
T2013	2070-2071	.	denotes	.
T2014	2072-2077	DT	denotes	These
T2015	2078-2081	VBP	denotes	are
T2016	2082-2085	DT	denotes	the
T2017	2086-2091	NNP	denotes	NLRP1
T2018	2092-2093	NNP	denotes	[
T2019	2093-2095	CD	denotes	12
T2020	2095-2096	NNP	denotes	]
T2021	2096-2097	,	denotes	,
T2022	2098-2103	NNP	denotes	NLRP3
T2023	2104-2105	NNP	denotes	[
T2024	2105-2107	CD	denotes	13
T2025	2107-2108	NNP	denotes	]
T2026	2108-2109	,	denotes	,
T2027	2110-2111	NNP	denotes	[
T2028	2111-2113	CD	denotes	14
T2029	2113-2114	NNP	denotes	]
T2030	2114-2115	,	denotes	,
T2031	2116-2121	NNP	denotes	NLRC4
T2032	2122-2123	NNP	denotes	[
T2033	2123-2125	CD	denotes	15
T2034	2125-2126	NNP	denotes	]
T2035	2126-2127	,	denotes	,
T2036	2128-2129	NNP	denotes	[
T2037	2129-2131	CD	denotes	16
T2038	2131-2132	NNP	denotes	]
T2039	2132-2133	,	denotes	,
T2040	2134-2137	CC	denotes	and
T2041	2138-2142	NNP	denotes	AIM2
T2042	2143-2156	VBZ	denotes	inflammasomes
T2043	2157-2158	NNP	denotes	[
T2044	2158-2160	CD	denotes	17
T2045	2160-2161	NNP	denotes	]
T2046	2161-2162	,	denotes	,
T2047	2163-2164	NNP	denotes	[
T2048	2164-2166	CD	denotes	18
T2049	2166-2167	NNP	denotes	]
T2050	2167-2168	,	denotes	,
T2051	2169-2174	WDT	denotes	which
T2052	2175-2182	VBP	denotes	respond
T2053	2183-2185	TO	denotes	to
T2054	2186-2187	DT	denotes	a
T2055	2188-2195	NN	denotes	variety
T2056	2196-2198	IN	denotes	of
T2057	2199-2208	JJ	denotes	different
T2058	2209-2218	JJ	denotes	microbial
T2059	2219-2229	NNS	denotes	signatures
T2060	2230-2233	CC	denotes	and
T2061	2234-2240	NN	denotes	danger
T2062	2241-2248	NNS	denotes	signals
T2063	2249-2250	NNP	denotes	[
T2064	2250-2252	CD	denotes	11
T2065	2252-2253	NNP	denotes	]
T2066	2253-2254	.	denotes	.
T2067	2255-2257	NNP	denotes	P.
T2068	2258-2268	NN	denotes	aeruginosa
T2069	2268-2269	,	denotes	,
T2070	2270-2273	CD	denotes	one
T2071	2274-2276	IN	denotes	of
T2072	2277-2280	DT	denotes	the
T2073	2281-2285	RBS	denotes	most
T2074	2286-2292	JJ	denotes	common
T2075	2293-2296	CC	denotes	and
T2076	2297-2307	RB	denotes	clinically
T2077	2308-2316	JJ	denotes	relevant
T2078	2317-2326	NNS	denotes	pathogens
T2079	2327-2332	IN	denotes	among
T2080	2333-2335	NNP	denotes	CF
T2081	2336-2344	NNS	denotes	patients
T2082	2344-2345	,	denotes	,
T2083	2346-2355	VBZ	denotes	activates
T2084	2356-2359	DT	denotes	the
T2085	2360-2365	NNP	denotes	NLRC4
T2086	2366-2378	JJ	denotes	inflammasome
T2087	2379-2380	NNP	denotes	[
T2088	2380-2382	CD	denotes	19
T2089	2382-2383	NNP	denotes	]
T2090	2383-2384	,	denotes	,
T2091	2385-2386	NNP	denotes	[
T2092	2386-2388	CD	denotes	20
T2093	2388-2389	NNP	denotes	]
T2094	2389-2390	.	denotes	.
T2095	2391-2400	NN	denotes	Infection
T2096	2401-2405	IN	denotes	with
T2097	2406-2408	NNP	denotes	P.
T2098	2409-2419	NN	denotes	aeruginosa
T2099	2420-2428	VBZ	denotes	triggers
T2100	2429-2431	DT	denotes	an
T2101	2432-2440	NN	denotes	increase
T2102	2441-2443	IN	denotes	in
T2103	2444-2450	NNS	denotes	levels
T2104	2451-2453	IN	denotes	of
T2105	2454-2459	NN	denotes	IL-1β
T2106	2459-2460	,	denotes	,
T2107	2461-2465	NNP	denotes	IL-6
T2108	2465-2466	,	denotes	,
T2109	2467-2470	CC	denotes	and
T2110	2471-2475	NNP	denotes	IL-8
T2111	2476-2478	IN	denotes	in
T2112	2479-2494	JJ	denotes	bronchoalveolar
T2113	2495-2501	NN	denotes	lavage
T2114	2502-2507	NN	denotes	fluid
T2115	2508-2509	-LRB-	denotes	(
T2116	2509-2513	NNP	denotes	BALF
T2117	2513-2514	-RRB-	denotes	)
T2118	2515-2519	IN	denotes	from
T2119	2520-2528	NNS	denotes	patients
T2120	2529-2533	IN	denotes	with
T2121	2534-2536	NNP	denotes	CF
T2122	2537-2538	NNP	denotes	[
T2123	2538-2540	CD	denotes	21
T2124	2540-2541	NNP	denotes	]
T2125	2541-2542	.	denotes	.
T2126	2543-2555	JJ	denotes	Inflammasome
T2127	2556-2565	NNS	denotes	responses
T2128	2566-2572	VBP	denotes	depend
T2129	2573-2575	IN	denotes	on
T2130	2576-2581	JJ	denotes	NF-κB
T2131	2582-2591	VBG	denotes	signaling
T2132	2591-2592	,	denotes	,
T2133	2593-2598	WRB	denotes	where
T2134	2599-2604	NNP	denotes	NF-κB
T2135	2605-2607	VBZ	denotes	is
T2136	2608-2617	JJ	denotes	important
T2137	2618-2620	IN	denotes	in
T2138	2621-2625	DT	denotes	both
T2139	2626-2629	DT	denotes	the
T2140	2630-2642	NN	denotes	upregulation
T2141	2643-2645	IN	denotes	of
T2142	2646-2654	JJ	denotes	specific
T2143	2655-2667	JJ	denotes	inflammasome
T2144	2668-2678	NNS	denotes	components
T2145	2679-2680	NNP	denotes	[
T2146	2680-2682	CD	denotes	22
T2147	2682-2683	NNP	denotes	]
T2148	2683-2684	,	denotes	,
T2149	2685-2686	NNP	denotes	[
T2150	2686-2688	CD	denotes	23
T2151	2688-2689	NNP	denotes	]
T2152	2689-2690	,	denotes	,
T2153	2691-2693	RB	denotes	as
T2154	2694-2698	RB	denotes	well
T2155	2699-2701	IN	denotes	as
T2156	2702-2707	JJ	denotes	IL-1β
T2157	2708-2718	NN	denotes	expression
T2158	2719-2720	NNP	denotes	[
T2159	2720-2722	CD	denotes	24
T2160	2722-2723	NNP	denotes	]
T2161	2723-2724	,	denotes	,
T2162	2725-2726	NNP	denotes	[
T2163	2726-2728	CD	denotes	25
T2164	2728-2729	NNP	denotes	]
T2165	2729-2730	.	denotes	.
T2166	2731-2739	JJ	denotes	Previous
T2167	2740-2747	NNS	denotes	studies
T2168	2748-2755	VBP	denotes	support
T2169	2756-2757	DT	denotes	a
T2170	2758-2762	NN	denotes	role
T2171	2763-2766	IN	denotes	for
T2172	2767-2772	NN	denotes	IL-1β
T2173	2773-2775	IN	denotes	in
T2174	2776-2779	DT	denotes	the
T2175	2780-2792	NN	denotes	pathogenesis
T2176	2793-2795	IN	denotes	of
T2177	2796-2798	NNP	denotes	CF
T2178	2799-2811	JJ	denotes	inflammatory
T2179	2812-2816	NN	denotes	lung
T2180	2817-2824	NN	denotes	disease
T2181	2824-2825	.	denotes	.
T2182	2826-2832	NNS	denotes	Levels
T2183	2833-2835	IN	denotes	of
T2184	2836-2841	NN	denotes	IL-1β
T2185	2842-2845	VBP	denotes	are
T2186	2846-2855	VBN	denotes	increased
T2187	2856-2858	IN	denotes	in
T2188	2859-2863	NNP	denotes	BALF
T2189	2864-2868	IN	denotes	from
T2190	2869-2871	NNP	denotes	CF
T2191	2872-2880	NNS	denotes	patients
T2192	2881-2885	IN	denotes	with
T2193	2886-2895	NN	denotes	infection
T2194	2896-2897	NNP	denotes	[
T2195	2897-2899	CD	denotes	21
T2196	2899-2900	NNP	denotes	]
T2197	2900-2901	,	denotes	,
T2198	2902-2903	NNP	denotes	[
T2199	2903-2905	CD	denotes	26
T2200	2905-2906	NNP	denotes	]
T2201	2906-2907	,	denotes	,
T2202	2908-2909	NNP	denotes	[
T2203	2909-2911	CD	denotes	27
T2204	2911-2912	NNP	denotes	]
T2205	2912-2913	,	denotes	,
T2206	2914-2915	NNP	denotes	[
T2207	2915-2917	CD	denotes	28
T2208	2917-2918	NNP	denotes	]
T2209	2919-2922	CC	denotes	and
T2210	2923-2927	DT	denotes	this
T2211	2928-2936	NN	denotes	increase
T2212	2937-2940	VBZ	denotes	has
T2213	2941-2945	VBN	denotes	been
T2214	2946-2956	RB	denotes	temporally
T2215	2957-2967	VBN	denotes	associated
T2216	2968-2972	IN	denotes	with
T2217	2973-2974	DT	denotes	a
T2218	2975-2983	JJ	denotes	clinical
T2219	2984-2992	NN	denotes	response
T2220	2993-2995	TO	denotes	to
T2221	2996-3005	NN	denotes	treatment
T2222	3006-3007	NNP	denotes	[
T2223	3007-3009	CD	denotes	21
T2224	3009-3010	NNP	denotes	]
T2225	3010-3011	.	denotes	.
T2226	3012-3025	NNS	denotes	Polymorphisms
T2227	3026-3028	IN	denotes	in
T2228	3029-3032	DT	denotes	the
T2229	3033-3037	NNP	denotes	IL1B
T2230	3038-3042	NN	denotes	gene
T2231	3043-3047	VBP	denotes	have
T2232	3048-3052	RB	denotes	also
T2233	3053-3057	VBN	denotes	been
T2234	3058-3068	VBN	denotes	associated
T2235	3069-3073	IN	denotes	with
T2236	3074-3081	VBG	denotes	varying
T2237	3082-3089	NNS	denotes	degrees
T2238	3090-3092	IN	denotes	of
T2239	3093-3100	NN	denotes	disease
T2240	3101-3109	NN	denotes	severity
T2241	3110-3112	IN	denotes	in
T2242	3113-3115	NNP	denotes	CF
T2243	3116-3124	NNS	denotes	patients
T2244	3125-3126	NNP	denotes	[
T2245	3126-3128	CD	denotes	29
T2246	3128-3129	NNP	denotes	]
T2247	3129-3130	.	denotes	.
T2248	3131-3137	NNP	denotes	Murine
T2249	3138-3144	NNS	denotes	models
T2250	3145-3147	IN	denotes	of
T2251	3148-3152	NNP	denotes	CFTR
T2252	3153-3164	NN	denotes	dysfunction
T2253	3165-3169	VBP	denotes	have
T2254	3170-3179	VBN	denotes	exhibited
T2255	3180-3191	JJ	denotes	significant
T2256	3192-3201	NNS	denotes	increases
T2257	3202-3204	IN	denotes	in
T2258	3205-3210	JJ	denotes	IL-1β
T2259	3211-3221	NN	denotes	expression
T2260	3222-3224	CC	denotes	or
T2261	3225-3234	NN	denotes	secretion
T2262	3235-3237	IN	denotes	in
T2263	3238-3249	NNS	denotes	macrophages
T2264	3250-3251	NNP	denotes	[
T2265	3251-3253	CD	denotes	30
T2266	3253-3254	NNP	denotes	]
T2267	3254-3255	,	denotes	,
T2268	3256-3257	NNP	denotes	[
T2269	3257-3259	CD	denotes	31
T2270	3259-3260	NNP	denotes	]
T2271	3260-3261	,	denotes	,
T2272	3262-3265	CC	denotes	and
T2273	3266-3273	VB	denotes	support
T2274	3274-3277	DT	denotes	the
T2275	3278-3288	NN	denotes	hypothesis
T2276	3289-3293	IN	denotes	that
T2277	3294-3297	DT	denotes	the
T2278	3298-3302	NN	denotes	loss
T2279	3303-3305	IN	denotes	of
T2280	3306-3310	NNP	denotes	CFTR
T2281	3311-3320	VBZ	denotes	increases
T2282	3321-3326	JJ	denotes	NF-κB
T2283	3327-3337	NN	denotes	activation
T2284	3338-3343	IN	denotes	under
T2285	3344-3349	NN	denotes	basal
T2286	3350-3353	CC	denotes	and
T2287	3354-3365	JJ	denotes	stimulatory
T2288	3366-3376	NNS	denotes	conditions
T2289	3377-3378	VBP	denotes	[
T2290	3378-3379	CD	denotes	4
T2291	3379-3380	NNP	denotes	]
T2292	3380-3381	,	denotes	,
T2293	3382-3383	NNP	denotes	[
T2294	3383-3384	CD	denotes	5
T2295	3384-3385	NNP	denotes	]
T2296	3385-3386	,	denotes	,
T2297	3387-3388	NNP	denotes	[
T2298	3388-3390	CD	denotes	32
T2299	3390-3391	NNP	denotes	]
T2300	3391-3392	,	denotes	,
T2301	3393-3394	NNP	denotes	[
T2302	3394-3396	CD	denotes	33
T2303	3396-3397	NNP	denotes	]
T2304	3397-3398	.	denotes	.
T2305	3399-3406	RB	denotes	Finally
T2306	3406-3407	,	denotes	,
T2307	3408-3419	NN	denotes	replacement
T2308	3420-3422	IN	denotes	of
T2309	3423-3431	NN	denotes	chloride
T2310	3432-3436	NNS	denotes	ions
T2311	3437-3441	IN	denotes	with
T2312	3442-3451	NN	denotes	glutamate
T2313	3452-3454	CC	denotes	or
T2314	3455-3464	NN	denotes	gluconate
T2315	3465-3467	IN	denotes	in
T2316	3468-3472	NN	denotes	cell
T2317	3473-3480	NN	denotes	culture
T2318	3481-3486	NNS	denotes	media
T2319	3487-3496	VBZ	denotes	increases
T2320	3497-3506	NN	denotes	secretion
T2321	3507-3509	IN	denotes	of
T2322	3510-3515	NN	denotes	IL-1β
T2323	3516-3518	IN	denotes	in
T2324	3519-3527	NN	denotes	response
T2325	3528-3530	TO	denotes	to
T2326	3531-3536	CD	denotes	NLRP3
T2327	3537-3548	NN	denotes	stimulation
T2328	3549-3551	IN	denotes	by
T2329	3552-3561	JJ	denotes	adenosine
T2330	3562-3574	NN	denotes	triphosphate
T2331	3575-3576	-LRB-	denotes	(
T2332	3576-3579	NNP	denotes	ATP
T2333	3579-3580	-RRB-	denotes	)
T2334	3581-3582	NNP	denotes	[
T2335	3582-3584	CD	denotes	34
T2336	3584-3585	NNP	denotes	]
T2337	3585-3586	,	denotes	,
T2338	3587-3595	VBG	denotes	implying
T2339	3596-3598	DT	denotes	an
T2340	3599-3609	JJ	denotes	inhibitory
T2341	3610-3614	NN	denotes	role
T2342	3615-3618	IN	denotes	for
T2343	3619-3632	JJ	denotes	extracellular
T2344	3633-3641	NN	denotes	chloride
T2345	3642-3644	IN	denotes	in
T2346	3645-3650	CD	denotes	NLRP3
T2347	3651-3661	NN	denotes	activation
T2348	3661-3662	.	denotes	.
T2349	3663-3668	VBN	denotes	Taken
T2350	3669-3677	RB	denotes	together
T2351	3677-3678	,	denotes	,
T2352	3679-3684	DT	denotes	these
T2353	3685-3689	NNS	denotes	data
T2354	3690-3699	VBP	denotes	implicate
T2355	3700-3703	DT	denotes	the
T2356	3704-3715	NN	denotes	involvement
T2357	3716-3718	IN	denotes	of
T2358	3719-3724	NN	denotes	IL-1β
T2359	3725-3728	CC	denotes	and
T2360	3729-3741	RB	denotes	consequently
T2361	3741-3742	,	denotes	,
T2362	3743-3746	DT	denotes	the
T2363	3747-3760	NNS	denotes	inflammasomes
T2364	3760-3761	,	denotes	,
T2365	3762-3764	IN	denotes	in
T2366	3765-3767	NNP	denotes	CF
T2367	3768-3780	JJ	denotes	inflammatory
T2368	3781-3788	NN	denotes	disease
T2369	3788-3789	.	denotes	.
R1433	T1659	T1660	amod	Cystic,fibrosis
R1434	T1660	T1661	nsubj	fibrosis,is
R1435	T1661	T1661	ROOT	is,is
R1436	T1662	T1665	det	an,disease
R1437	T1663	T1665	amod	autosomal,disease
R1438	T1664	T1665	amod	recessive,disease
R1439	T1665	T1661	attr	disease,is
R1440	T1666	T1665	acl	caused,disease
R1441	T1667	T1666	agent	by,caused
R1442	T1668	T1667	pobj	mutations,by
R1443	T1669	T1668	prep	in,mutations
R1444	T1670	T1675	det	the,regulator
R1445	T1671	T1675	amod	cystic,regulator
R1446	T1672	T1675	nmod	fibrosis,regulator
R1447	T1673	T1675	nmod	transmembrane,regulator
R1448	T1674	T1675	compound	conductance,regulator
R1449	T1675	T1669	pobj	regulator,in
R1450	T1676	T1675	punct	(,regulator
R1451	T1677	T1675	appos	CFTR,regulator
R1452	T1678	T1675	punct	),regulator
R1453	T1679	T1675	punct	",",regulator
R1454	T1680	T1681	nsubj	which,functions
R1455	T1681	T1668	relcl	functions,mutations
R1456	T1682	T1681	prep	as,functions
R1457	T1683	T1686	det	a,channel
R1458	T1684	T1686	compound	chloride,channel
R1459	T1685	T1686	compound	ion,channel
R1460	T1686	T1682	pobj	channel,as
R1461	T1687	T1661	punct	.,is
R1462	T1688	T1689	nsubj	CF,remains
R1463	T1689	T1689	ROOT	remains,remains
R1464	T1690	T1689	attr	one,remains
R1465	T1691	T1690	prep	of,one
R1466	T1692	T1697	det	the,diseases
R1467	T1693	T1694	advmod	most,common
R1468	T1694	T1697	amod	common,diseases
R1469	T1695	T1697	amod	lethal,diseases
R1470	T1696	T1697	amod	genetic,diseases
R1471	T1697	T1691	pobj	diseases,of
R1472	T1698	T1697	prep	in,diseases
R1473	T1699	T1698	pobj	populations,in
R1474	T1700	T1699	prep	of,populations
R1475	T1701	T1702	amod	European,descent
R1476	T1702	T1700	pobj	descent,of
R1477	T1703	T1690	prep	with,one
R1478	T1704	T1707	det	the,lifespan
R1479	T1705	T1707	amod	current,lifespan
R1480	T1706	T1707	amod	average,lifespan
R1481	T1707	T1703	pobj	lifespan,with
R1482	T1708	T1707	prep	of,lifespan
R1483	T1709	T1710	compound	CF,patients
R1484	T1710	T1708	pobj	patients,of
R1485	T1711	T1712	advmod	approximately,40
R1486	T1712	T1713	nummod	40,years
R1487	T1713	T1707	appos	years,lifespan
R1488	T1714	T1713	prep	of,years
R1489	T1715	T1714	pobj	age,of
R1490	T1716	T1718	nmod	[,]
R1491	T1717	T1718	nummod	1,]
R1492	T1718	T1713	appos	],years
R1493	T1719	T1718	punct	",",]
R1494	T1720	T1722	nmod	[,]
R1495	T1721	T1722	nummod	2,]
R1496	T1722	T1718	appos	],]
R1497	T1723	T1689	punct	.,remains
R1498	T1724	T1727	amod	Recurrent,exacerbation
R1499	T1725	T1727	amod	inflammatory,exacerbation
R1500	T1726	T1727	amod	pulmonary,exacerbation
R1501	T1727	T1728	nsubj	exacerbation,is
R1502	T1728	T1728	ROOT	is,is
R1503	T1729	T1731	det	the,cause
R1504	T1730	T1731	amod	primary,cause
R1505	T1731	T1728	attr	cause,is
R1506	T1732	T1731	prep	of,cause
R1507	T1733	T1734	compound	lung,disease
R1508	T1734	T1735	compound	disease,progression
R1509	T1735	T1732	pobj	progression,of
R1510	T1736	T1731	cc	and,cause
R1511	T1737	T1744	advmod	ultimately,is
R1512	T1738	T1744	punct	",",is
R1513	T1739	T1744	nsubj	death,is
R1514	T1740	T1739	prep	in,death
R1515	T1741	T1743	compound	CF.,inflammation
R1516	T1742	T1743	compound	Controlled,inflammation
R1517	T1743	T1740	pobj	inflammation,in
R1518	T1744	T1728	conj	is,is
R1519	T1745	T1744	acomp	important,is
R1520	T1746	T1745	prep	for,important
R1521	T1747	T1746	pcomp	fighting,for
R1522	T1748	T1747	dobj	infection,fighting
R1523	T1749	T1744	punct	",",is
R1524	T1750	T1744	cc	but,is
R1525	T1751	T1755	prep	in,becomes
R1526	T1752	T1751	pobj	excess,in
R1527	T1753	T1755	punct	",",becomes
R1528	T1754	T1755	nsubj	it,becomes
R1529	T1755	T1744	conj	becomes,is
R1530	T1756	T1755	acomp	destructive,becomes
R1531	T1757	T1758	aux	to,host
R1532	T1758	T1755	xcomp	host,becomes
R1533	T1759	T1758	dobj	cells,host
R1534	T1760	T1758	cc	and,host
R1535	T1761	T1758	prep	to,host
R1536	T1762	T1763	det	the,architecture
R1537	T1763	T1761	pobj	architecture,to
R1538	T1764	T1763	prep	of,architecture
R1539	T1765	T1766	det	the,lungs
R1540	T1766	T1764	pobj	lungs,of
R1541	T1767	T1769	nmod	[,]
R1542	T1768	T1769	nummod	2,]
R1543	T1769	T1773	nmod	],]
R1544	T1770	T1769	punct	",",]
R1545	T1771	T1773	nmod	[,]
R1546	T1772	T1773	nummod	3,]
R1547	T1773	T1755	npadvmod	],becomes
R1548	T1774	T1755	punct	.,becomes
R1549	T1775	T1783	prep	In,shown
R1550	T1776	T1775	pobj	CF,In
R1551	T1777	T1783	punct	",",shown
R1552	T1778	T1780	amod	airway,cells
R1553	T1779	T1780	amod	epithelial,cells
R1554	T1780	T1783	nsubjpass	cells,shown
R1555	T1781	T1783	aux	have,shown
R1556	T1782	T1783	auxpass	been,shown
R1557	T1783	T1783	ROOT	shown,shown
R1558	T1784	T1785	aux	to,produce
R1559	T1785	T1783	xcomp	produce,shown
R1560	T1786	T1790	det	an,response
R1561	T1787	T1790	amod	exaggerated,response
R1562	T1788	T1790	amod	pro-inflammatory,response
R1563	T1789	T1790	compound	cytokine,response
R1564	T1790	T1785	dobj	response,produce
R1565	T1791	T1792	aux	to,stimulation
R1566	T1792	T1790	relcl	stimulation,response
R1567	T1793	T1795	nmod	[,]
R1568	T1794	T1795	nummod	4,]
R1569	T1795	T1792	dobj	],stimulation
R1570	T1796	T1795	punct	",",]
R1571	T1797	T1795	appos	[,]
R1572	T1798	T1799	nummod	5,]
R1573	T1799	T1795	conj	],]
R1574	T1800	T1783	punct	.,shown
R1575	T1801	T1802	nsubj	It,is
R1576	T1802	T1802	ROOT	is,is
R1577	T1803	T1802	acomp	unclear,is
R1578	T1804	T1809	mark	whether,is
R1579	T1805	T1808	det	this,response
R1580	T1806	T1808	amod	heightened,response
R1581	T1807	T1808	amod	inflammatory,response
R1582	T1808	T1809	nsubj	response,is
R1583	T1809	T1802	ccomp	is,is
R1584	T1810	T1809	acomp	intrinsic,is
R1585	T1811	T1810	prep	to,intrinsic
R1586	T1812	T1811	pobj	cells,to
R1587	T1813	T1812	acl	lacking,cells
R1588	T1814	T1813	dobj	CFTR,lacking
R1589	T1815	T1809	cc	or,is
R1590	T1816	T1818	mark	whether,is
R1591	T1817	T1818	nsubj	it,is
R1592	T1818	T1809	conj	is,is
R1593	T1819	T1820	det	a,result
R1594	T1820	T1818	attr	result,is
R1595	T1821	T1820	prep	of,result
R1596	T1822	T1825	amod	chronic,[
R1597	T1823	T1824	amod	polymicrobial,infection
R1598	T1824	T1825	compound	infection,[
R1599	T1825	T1827	nmod	[,]
R1600	T1826	T1827	nummod	6,]
R1601	T1827	T1821	pobj	],of
R1602	T1828	T1827	punct	",",]
R1603	T1829	T1831	nmod	[,]
R1604	T1830	T1831	nummod	7,]
R1605	T1831	T1827	appos	],]
R1606	T1832	T1802	punct	.,is
R1607	T1833	T1844	advmod	Regardless,is
R1608	T1834	T1833	prep	of,Regardless
R1609	T1835	T1836	det	this,controversy
R1610	T1836	T1834	pobj	controversy,of
R1611	T1837	T1833	punct	",",Regardless
R1612	T1935	T1945	prep	Following,produced
R1613	T1936	T1935	pobj	initiation,Following
R1614	T1937	T1936	prep	of,initiation
R1615	T1938	T1939	det	the,NF-κB
R1616	T1939	T1937	pobj	NF-κB,of
R1617	T1940	T1936	acl	signaling,initiation
R1618	T1941	T1940	dobj	cascade,signaling
R1619	T1942	T1945	punct	",",produced
R1620	T1943	T1945	nsubjpass	IL-1β,produced
R1621	T1944	T1945	auxpass	is,produced
R1622	T1945	T1945	ROOT	produced,produced
R1623	T1946	T1945	prep	in,produced
R1624	T1947	T1948	det	the,cytosol
R1625	T1948	T1946	pobj	cytosol,in
R1626	T1949	T1945	prep	as,produced
R1627	T1950	T1954	det	a,pro-IL-1β
R1628	T1838	T1844	csubj	identifying,is
R1629	T1951	T1952	advmod	biologically,inactive
R1630	T1839	T1838	cc	and,identifying
R1631	T1952	T1954	amod	inactive,pro-IL-1β
R1632	T1840	T1838	conj	targeting,identifying
R1633	T1841	T1843	amod	relevant,mediators
R1634	T1953	T1954	amod	full-length,pro-IL-1β
R1635	T1842	T1843	amod	inflammatory,mediators
R1636	T1843	T1840	dobj	mediators,targeting
R1637	T1844	T1844	ROOT	is,is
R1638	T1954	T1949	pobj	pro-IL-1β,as
R1639	T1845	T1847	det	a,step
R1640	T1846	T1847	amod	critical,step
R1641	T1955	T1945	punct	.,produced
R1642	T1956	T1959	nsubjpass	Pro-IL-1β,converted
R1643	T1847	T1844	attr	step,is
R1644	T1957	T1959	auxpass	is,converted
R1645	T1848	T1847	prep	in,step
R1646	T1958	T1959	advmod	subsequently,converted
R1647	T1849	T1848	pcomp	developing,in
R1648	T1850	T1851	advmod	more,specific
R1649	T1851	T1853	amod	specific,approaches
R1650	T1852	T1853	amod	therapeutic,approaches
R1651	T1959	T1959	ROOT	converted,converted
R1652	T1853	T1849	dobj	approaches,developing
R1653	T1854	T1855	aux	to,control
R1654	T1855	T1853	relcl	control,approaches
R1655	T1856	T1855	dobj	inflammation,control
R1656	T1857	T1855	cc	and,control
R1657	T1858	T1855	conj	improve,control
R1658	T1859	T1860	compound	health,outcomes
R1659	T1960	T1959	prep	into,converted
R1660	T1860	T1858	dobj	outcomes,improve
R1661	T1861	T1860	prep	in,outcomes
R1662	T1862	T1863	compound	CF,[
R1663	T1961	T1963	poss	its,form
R1664	T1863	T1861	pobj	[,in
R1665	T1864	T1865	nummod	8,]
R1666	T1865	T1863	appos	],[
R1667	T1962	T1963	amod	active,form
R1668	T1866	T1844	punct	.,is
R1669	T1963	T1960	pobj	form,into
R1670	T1867	T1868	compound	Interleukin-1,beta
R1671	T1868	T1872	nsubj	beta,is
R1672	T1869	T1868	punct	(,beta
R1673	T1870	T1868	appos	IL-1β,beta
R1674	T1964	T1959	agent	by,converted
R1675	T1871	T1868	punct	),beta
R1676	T1872	T1872	ROOT	is,is
R1677	T1965	T1967	amod	cytosolic,complexes
R1678	T1873	T1876	det	a,mediator
R1679	T1874	T1876	amod	major,mediator
R1680	T1875	T1876	amod	inflammatory,mediator
R1681	T1966	T1967	compound	protein,complexes
R1682	T1876	T1872	attr	mediator,is
R1683	T1877	T1872	punct	.,is
R1684	T1967	T1964	pobj	complexes,by
R1685	T1878	T1880	poss	Its,effects
R1686	T1879	T1880	amod	physiological,effects
R1687	T1968	T1968	ROOT	termed,termed
R1688	T1969	T1968	oprd	inflammasomes,termed
R1689	T1880	T1881	nsubj	effects,are
R1690	T1881	T1881	ROOT	are,are
R1691	T1970	T1959	punct	.,converted
R1692	T1882	T1881	acomp	diverse,are
R1693	T1883	T1882	cc	and,diverse
R1694	T1971	T1972	nsubj	Inflammasomes,assemble
R1695	T1884	T1885	advmod	potentially,important
R1696	T1885	T1882	conj	important,diverse
R1697	T1972	T1972	ROOT	assemble,assemble
R1698	T1886	T1885	prep	to,important
R1699	T1887	T1888	det	the,pathogenesis
R1700	T1973	T1972	prep	in,assemble
R1701	T1888	T1886	pobj	pathogenesis,to
R1702	T1889	T1888	prep	of,pathogenesis
R1703	T1890	T1891	compound	lung,exacerbations
R1704	T1891	T1889	pobj	exacerbations,of
R1705	T1974	T1973	pobj	response,in
R1706	T1892	T1891	prep	in,exacerbations
R1707	T1893	T1892	pobj	CF,in
R1708	T1975	T1974	prep	to,response
R1709	T1894	T1891	punct	",",exacerbations
R1710	T1895	T1888	prep	including,pathogenesis
R1711	T1976	T1979	amod	certain,signals
R1712	T1896	T1897	det	the,generation
R1713	T1897	T1895	pobj	generation,including
R1714	T1898	T1897	prep	of,generation
R1715	T1977	T1978	amod	cellular,danger
R1716	T1899	T1898	pobj	fever,of
R1717	T1900	T1888	punct	",",pathogenesis
R1718	T1978	T1979	compound	danger,signals
R1719	T1901	T1902	det	the,recruitment
R1720	T1902	T1888	appos	recruitment,pathogenesis
R1721	T1979	T1975	pobj	signals,to
R1722	T1903	T1902	prep	of,recruitment
R1723	T1904	T1906	amod	inflammatory,cells
R1724	T1905	T1906	compound	effector,cells
R1725	T1980	T1972	cc	and,assemble
R1726	T1906	T1903	pobj	cells,of
R1727	T1907	T1888	punct	",",pathogenesis
R1728	T1981	T1972	conj	mediate,assemble
R1729	T1908	T1909	det	the,induction
R1730	T1909	T1927	nsubj	induction,[
R1731	T1910	T1909	prep	of,induction
R1732	T1911	T1913	amod	other,cytokines
R1733	T1912	T1913	amod	pro-inflammatory,cytokines
R1734	T1982	T1983	det	the,auto-activation
R1735	T1913	T1910	pobj	cytokines,of
R1736	T1914	T1915	amod	such,as
R1737	T1983	T1981	dobj	auto-activation,mediate
R1738	T1915	T1913	prep	as,cytokines
R1739	T1916	T1915	pobj	IL-6,as
R1740	T1917	T1916	cc	and,IL-6
R1741	T1984	T1983	prep	of,auto-activation
R1742	T1918	T1916	conj	IL-8,IL-6
R1743	T1919	T1918	punct	",",IL-8
R1744	T1985	T1986	amod	caspase-1,[
R1745	T1920	T1918	cc	and,IL-8
R1746	T1921	T1922	det	the,shaping
R1747	T1922	T1918	conj	shaping,IL-8
R1748	T1923	T1922	prep	of,shaping
R1749	T1986	T1988	nmod	[,]
R1750	T1924	T1926	compound	T,responses
R1751	T1925	T1926	compound	cell,responses
R1752	T1987	T1986	nummod	9,[
R1753	T1926	T1923	pobj	responses,of
R1754	T1927	T1881	conj	[,are
R1755	T1928	T1929	nummod	9,]
R1756	T1929	T1927	dobj	],[
R1757	T1930	T1929	punct	",",]
R1758	T1931	T1929	appos	[,]
R1759	T1988	T1984	pobj	],of
R1760	T1932	T1933	nummod	10,]
R1761	T1933	T1929	appos	],]
R1762	T1934	T1927	punct	.,[
R1763	T1989	T1988	punct	",",]
R1764	T1990	T1992	compound	[,]
R1765	T1991	T1992	compound	11,]
R1766	T1992	T1983	appos	],auto-activation
R1767	T1993	T1992	punct	",",]
R1768	T1994	T1995	nsubj	which,cleaves
R1769	T2032	T2029	conj	[,]
R1770	T2033	T2034	nummod	15,]
R1771	T1995	T1992	relcl	cleaves,]
R1772	T2034	T2032	conj	],[
R1773	T2035	T2034	punct	",",]
R1774	T2036	T2034	conj	[,]
R1775	T1996	T1995	dobj	pro-IL-1β,cleaves
R1776	T2037	T2038	nummod	16,]
R1777	T2038	T2034	conj	],]
R1778	T1997	T1996	cc	and,pro-IL-1β
R1779	T2039	T2038	punct	",",]
R1780	T2040	T2038	cc	and,]
R1781	T1998	T1996	conj	pro-IL-18,pro-IL-1β
R1782	T2041	T2038	conj	AIM2,]
R1783	T2042	T2043	compound	inflammasomes,[
R1784	T2043	T2020	conj	[,]
R1785	T1999	T1995	prep	into,cleaves
R1786	T2044	T2045	nummod	17,]
R1787	T2045	T2043	conj	],[
R1788	T2046	T2045	punct	",",]
R1789	T2000	T2003	poss	their,forms
R1790	T2047	T2049	nmod	[,]
R1791	T2048	T2049	nummod	18,]
R1792	T2049	T2045	conj	],]
R1793	T2001	T2002	advmod	biologically,active
R1794	T2002	T2003	amod	active,forms
R1795	T2050	T2049	punct	",",]
R1796	T2003	T1999	pobj	forms,into
R1797	T2004	T2003	prep	for,forms
R1798	T2051	T2052	nsubj	which,respond
R1799	T2005	T2004	pobj	secretion,for
R1800	T2052	T2020	relcl	respond,]
R1801	T2053	T2052	prep	to,respond
R1802	T2006	T1972	punct	.,assemble
R1803	T2054	T2055	det	a,variety
R1804	T2055	T2053	pobj	variety,to
R1805	T2056	T2055	prep	of,variety
R1806	T2057	T2059	amod	different,signatures
R1807	T2007	T2009	nummod	Four,inflammasomes
R1808	T2058	T2059	amod	microbial,signatures
R1809	T2059	T2056	pobj	signatures,of
R1810	T2060	T2059	cc	and,signatures
R1811	T2008	T2009	amod	distinct,inflammasomes
R1812	T2061	T2062	nsubj	danger,signals
R1813	T2009	T2012	nsubjpass	inflammasomes,recognized
R1814	T2010	T2012	aux	have,recognized
R1815	T2062	T2059	conj	signals,signatures
R1816	T2011	T2012	auxpass	been,recognized
R1817	T2012	T2012	ROOT	recognized,recognized
R1818	T2063	T2065	nmod	[,]
R1819	T2064	T2065	nummod	11,]
R1820	T2013	T2012	punct	.,recognized
R1821	T2065	T2055	appos	],variety
R1822	T2066	T2015	punct	.,are
R1823	T2014	T2015	nsubj	These,are
R1824	T2067	T2068	compound	P.,aeruginosa
R1825	T2068	T2083	nsubj	aeruginosa,activates
R1826	T2015	T2015	ROOT	are,are
R1827	T2069	T2068	punct	",",aeruginosa
R1828	T2070	T2068	appos	one,aeruginosa
R1829	T2071	T2070	prep	of,one
R1830	T2016	T2020	det	the,]
R1831	T2072	T2078	det	the,pathogens
R1832	T2073	T2074	advmod	most,common
R1833	T2017	T2018	compound	NLRP1,[
R1834	T2074	T2078	amod	common,pathogens
R1835	T2075	T2074	cc	and,common
R1836	T2076	T2077	advmod	clinically,relevant
R1837	T2018	T2020	nmod	[,]
R1838	T2077	T2074	conj	relevant,common
R1839	T2078	T2071	pobj	pathogens,of
R1840	T2019	T2020	nummod	12,]
R1841	T2079	T2078	prep	among,pathogens
R1842	T2080	T2081	compound	CF,patients
R1843	T2081	T2079	pobj	patients,among
R1844	T2020	T2015	attr	],are
R1845	T2082	T2068	punct	",",aeruginosa
R1846	T2083	T2083	ROOT	activates,activates
R1847	T2021	T2020	punct	",",]
R1848	T2084	T2089	det	the,]
R1849	T2085	T2087	nmod	NLRC4,[
R1850	T2086	T2087	compound	inflammasome,[
R1851	T2022	T2023	compound	NLRP3,[
R1852	T2087	T2089	nmod	[,]
R1853	T2088	T2089	nummod	19,]
R1854	T2089	T2083	dobj	],activates
R1855	T2090	T2089	punct	",",]
R1856	T2091	T2089	conj	[,]
R1857	T2023	T2020	appos	[,]
R1858	T2024	T2025	nummod	13,]
R1859	T2092	T2093	nummod	20,]
R1860	T2093	T2089	conj	],]
R1861	T2025	T2020	conj	],]
R1862	T2094	T2083	punct	.,activates
R1863	T2095	T2099	nsubj	Infection,triggers
R1864	T2026	T2025	punct	",",]
R1865	T2096	T2095	prep	with,Infection
R1866	T2097	T2098	compound	P.,aeruginosa
R1867	T2098	T2096	pobj	aeruginosa,with
R1868	T2027	T2025	conj	[,]
R1869	T2099	T2099	ROOT	triggers,triggers
R1870	T2100	T2101	det	an,increase
R1871	T2028	T2029	nummod	14,]
R1872	T2101	T2099	dobj	increase,triggers
R1873	T2102	T2101	prep	in,increase
R1874	T2029	T2025	conj	],]
R1875	T2103	T2102	pobj	levels,in
R1876	T2104	T2103	prep	of,levels
R1877	T2105	T2104	pobj	IL-1β,of
R1878	T2030	T2029	punct	",",]
R1879	T2106	T2105	punct	",",IL-1β
R1880	T2107	T2105	conj	IL-6,IL-1β
R1881	T2031	T2032	compound	NLRC4,[
R1882	T2108	T2107	punct	",",IL-6
R1883	T2109	T2107	cc	and,IL-6
R1884	T2110	T2107	conj	IL-8,IL-6
R1885	T2129	T2128	prep	on,depend
R1886	T2111	T2107	prep	in,IL-6
R1887	T2112	T2114	nmod	bronchoalveolar,fluid
R1888	T2113	T2114	compound	lavage,fluid
R1889	T2114	T2111	pobj	fluid,in
R1890	T2115	T2116	punct	(,BALF
R1891	T2116	T2114	appos	BALF,fluid
R1892	T2130	T2131	amod	NF-κB,signaling
R1893	T2117	T2116	punct	),BALF
R1894	T2118	T2101	prep	from,increase
R1895	T2131	T2129	pcomp	signaling,on
R1896	T2119	T2118	pobj	patients,from
R1897	T2120	T2119	prep	with,patients
R1898	T2121	T2122	compound	CF,[
R1899	T2132	T2131	punct	",",signaling
R1900	T2122	T2120	pobj	[,with
R1901	T2123	T2124	nummod	21,]
R1902	T2124	T2122	appos	],[
R1903	T2133	T2135	advmod	where,is
R1904	T2125	T2099	punct	.,triggers
R1905	T2126	T2127	amod	Inflammasome,responses
R1906	T2127	T2128	nsubj	responses,depend
R1907	T2128	T2128	ROOT	depend,depend
R1908	T2134	T2135	nsubj	NF-κB,is
R1909	T2135	T2129	pcomp	is,on
R1910	T2136	T2135	acomp	important,is
R1911	T2226	T2234	nsubj	Polymorphisms,associated
R1912	T2137	T2135	prep	in,is
R1913	T2227	T2226	prep	in,Polymorphisms
R1914	T2228	T2230	det	the,gene
R1915	T2229	T2230	compound	IL1B,gene
R1916	T2138	T2140	preconj	both,upregulation
R1917	T2230	T2227	pobj	gene,in
R1918	T2231	T2234	aux	have,associated
R1919	T2139	T2140	det	the,upregulation
R1920	T2232	T2234	advmod	also,associated
R1921	T2233	T2234	auxpass	been,associated
R1922	T2234	T2234	ROOT	associated,associated
R1923	T2140	T2137	pobj	upregulation,in
R1924	T2235	T2234	prep	with,associated
R1925	T2236	T2237	amod	varying,degrees
R1926	T2237	T2235	pobj	degrees,with
R1927	T2141	T2140	prep	of,upregulation
R1928	T2142	T2144	amod	specific,components
R1929	T2238	T2237	prep	of,degrees
R1930	T2239	T2240	compound	disease,severity
R1931	T2143	T2144	amod	inflammasome,components
R1932	T2240	T2238	pobj	severity,of
R1933	T2241	T2240	prep	in,severity
R1934	T2242	T2243	compound	CF,patients
R1935	T2144	T2141	pobj	components,of
R1936	T2243	T2241	pobj	patients,in
R1937	T2244	T2243	appos	[,patients
R1938	T2245	T2246	nummod	29,]
R1939	T2145	T2147	nmod	[,]
R1940	T2246	T2244	appos	],[
R1941	T2247	T2234	punct	.,associated
R1942	T2248	T2249	compound	Murine,models
R1943	T2146	T2147	nummod	22,]
R1944	T2249	T2254	nsubj	models,exhibited
R1945	T2250	T2249	prep	of,models
R1946	T2251	T2252	amod	CFTR,dysfunction
R1947	T2147	T2140	appos	],upregulation
R1948	T2252	T2250	pobj	dysfunction,of
R1949	T2253	T2254	aux	have,exhibited
R1950	T2254	T2254	ROOT	exhibited,exhibited
R1951	T2148	T2147	punct	",",]
R1952	T2255	T2256	amod	significant,increases
R1953	T2256	T2254	dobj	increases,exhibited
R1954	T2257	T2256	prep	in,increases
R1955	T2258	T2259	amod	IL-1β,expression
R1956	T2259	T2257	pobj	expression,in
R1957	T2260	T2259	cc	or,expression
R1958	T2149	T2151	nmod	[,]
R1959	T2261	T2259	conj	secretion,expression
R1960	T2262	T2259	prep	in,expression
R1961	T2263	T2262	pobj	macrophages,in
R1962	T2264	T2266	nmod	[,]
R1963	T2150	T2151	nummod	23,]
R1964	T2265	T2266	nummod	30,]
R1965	T2266	T2256	conj	],increases
R1966	T2151	T2147	appos	],]
R1967	T2152	T2151	punct	",",]
R1968	T2267	T2266	punct	",",]
R1969	T2268	T2270	nmod	[,]
R1970	T2153	T2155	advmod	as,as
R1971	T2269	T2270	nummod	31,]
R1972	T2270	T2266	conj	],]
R1973	T2154	T2155	advmod	well,as
R1974	T2271	T2270	punct	",",]
R1975	T2272	T2254	cc	and,exhibited
R1976	T2273	T2254	conj	support,exhibited
R1977	T2155	T2151	cc	as,]
R1978	T2274	T2275	det	the,hypothesis
R1979	T2275	T2273	dobj	hypothesis,support
R1980	T2156	T2157	amod	IL-1β,expression
R1981	T2276	T2281	mark	that,increases
R1982	T2277	T2278	det	the,loss
R1983	T2278	T2281	nsubj	loss,increases
R1984	T2157	T2160	nmod	expression,]
R1985	T2279	T2278	prep	of,loss
R1986	T2280	T2281	compound	CFTR,increases
R1987	T2281	T2275	acl	increases,hypothesis
R1988	T2158	T2160	nmod	[,]
R1989	T2282	T2283	amod	NF-κB,activation
R1990	T2283	T2281	dobj	activation,increases
R1991	T2284	T2283	prep	under,activation
R1992	T2159	T2160	nummod	24,]
R1993	T2285	T2284	pobj	basal,under
R1994	T2160	T2151	conj	],]
R1995	T2286	T2285	cc	and,basal
R1996	T2287	T2285	conj	stimulatory,basal
R1997	T2161	T2160	punct	",",]
R1998	T2288	T2289	nsubj	conditions,[
R1999	T2289	T2291	nmod	[,]
R2000	T2290	T2291	nummod	4,]
R2001	T2162	T2164	compound	[,]
R2002	T2291	T2291	ROOT	],]
R2003	T2292	T2291	punct	",",]
R2004	T2163	T2164	nummod	25,]
R2005	T2293	T2295	nmod	[,]
R2006	T2294	T2295	nummod	5,]
R2007	T2295	T2291	conj	],]
R2008	T2296	T2295	punct	",",]
R2009	T2297	T2295	conj	[,]
R2010	T2298	T2299	nummod	32,]
R2011	T2164	T2160	appos	],]
R2012	T2299	T2295	conj	],]
R2013	T2300	T2299	punct	",",]
R2014	T2301	T2299	conj	[,]
R2015	T2165	T2128	punct	.,depend
R2016	T2302	T2303	nummod	33,]
R2017	T2303	T2299	conj	],]
R2018	T2304	T2254	punct	.,exhibited
R2019	T2166	T2167	amod	Previous,studies
R2020	T2305	T2319	advmod	Finally,increases
R2021	T2306	T2319	punct	",",increases
R2022	T2307	T2319	nsubj	replacement,increases
R2023	T2167	T2168	nsubj	studies,support
R2024	T2308	T2307	prep	of,replacement
R2025	T2309	T2310	compound	chloride,ions
R2026	T2168	T2168	ROOT	support,support
R2027	T2310	T2308	pobj	ions,of
R2028	T2311	T2307	prep	with,replacement
R2029	T2312	T2311	pobj	glutamate,with
R2030	T2313	T2312	cc	or,glutamate
R2031	T2169	T2170	det	a,role
R2032	T2314	T2312	conj	gluconate,glutamate
R2033	T2315	T2307	prep	in,replacement
R2034	T2170	T2168	dobj	role,support
R2035	T2316	T2317	compound	cell,culture
R2036	T2317	T2318	compound	culture,media
R2037	T2318	T2315	pobj	media,in
R2038	T2171	T2170	prep	for,role
R2039	T2319	T2319	ROOT	increases,increases
R2040	T2320	T2319	dobj	secretion,increases
R2041	T2321	T2320	prep	of,secretion
R2042	T2172	T2171	pobj	IL-1β,for
R2043	T2322	T2321	pobj	IL-1β,of
R2044	T2173	T2170	prep	in,role
R2045	T2174	T2175	det	the,pathogenesis
R2046	T2175	T2173	pobj	pathogenesis,in
R2047	T2323	T2319	prep	in,increases
R2048	T2176	T2175	prep	of,pathogenesis
R2049	T2177	T2180	nmod	CF,disease
R2050	T2324	T2323	pobj	response,in
R2051	T2178	T2180	amod	inflammatory,disease
R2052	T2179	T2180	compound	lung,disease
R2053	T2325	T2324	prep	to,response
R2054	T2326	T2327	nummod	NLRP3,stimulation
R2055	T2327	T2325	pobj	stimulation,to
R2056	T2328	T2319	prep	by,increases
R2057	T2329	T2330	amod	adenosine,triphosphate
R2058	T2330	T2328	pobj	triphosphate,by
R2059	T2180	T2176	pobj	disease,of
R2060	T2331	T2332	punct	(,ATP
R2061	T2332	T2330	appos	ATP,triphosphate
R2062	T2333	T2332	punct	),ATP
R2063	T2334	T2336	nmod	[,]
R2064	T2181	T2168	punct	.,support
R2065	T2335	T2336	nummod	34,]
R2066	T2336	T2330	conj	],triphosphate
R2067	T2337	T2319	punct	",",increases
R2068	T2182	T2186	nsubjpass	Levels,increased
R2069	T2338	T2319	advcl	implying,increases
R2070	T2339	T2341	det	an,role
R2071	T2340	T2341	amod	inhibitory,role
R2072	T2183	T2182	prep	of,Levels
R2073	T2341	T2338	dobj	role,implying
R2074	T2342	T2341	prep	for,role
R2075	T2343	T2344	amod	extracellular,chloride
R2076	T2184	T2183	pobj	IL-1β,of
R2077	T2344	T2342	pobj	chloride,for
R2078	T2345	T2341	prep	in,role
R2079	T2346	T2347	nummod	NLRP3,activation
R2080	T2185	T2186	auxpass	are,increased
R2081	T2347	T2345	pobj	activation,in
R2082	T2348	T2319	punct	.,increases
R2083	T2186	T2186	ROOT	increased,increased
R2084	T2349	T2354	advcl	Taken,implicate
R2085	T2350	T2349	advmod	together,Taken
R2086	T2351	T2354	punct	",",implicate
R2087	T2187	T2186	prep	in,increased
R2088	T2352	T2353	det	these,data
R2089	T2353	T2354	nsubj	data,implicate
R2090	T2354	T2354	ROOT	implicate,implicate
R2091	T2188	T2187	pobj	BALF,in
R2092	T2355	T2356	det	the,involvement
R2093	T2189	T2186	prep	from,increased
R2094	T2356	T2354	dobj	involvement,implicate
R2095	T2357	T2356	prep	of,involvement
R2096	T2190	T2191	compound	CF,patients
R2097	T2358	T2357	pobj	IL-1β,of
R2098	T2359	T2354	cc	and,implicate
R2099	T2360	T2363	advmod	consequently,inflammasomes
R2100	T2191	T2189	pobj	patients,from
R2101	T2361	T2363	punct	",",inflammasomes
R2102	T2362	T2363	det	the,inflammasomes
R2103	T2363	T2354	conj	inflammasomes,implicate
R2104	T2192	T2186	prep	with,increased
R2105	T2364	T2363	punct	",",inflammasomes
R2106	T2365	T2363	prep	in,inflammasomes
R2107	T2193	T2192	pobj	infection,with
R2108	T2366	T2368	nmod	CF,disease
R2109	T2367	T2368	amod	inflammatory,disease
R2110	T2194	T2196	nmod	[,]
R2111	T2368	T2365	pobj	disease,in
R2112	T2369	T2354	punct	.,implicate
R2113	T2195	T2196	nummod	21,]
R2114	T2196	T2215	nsubjpass	],associated
R2115	T2197	T2196	punct	",",]
R2116	T2198	T2196	appos	[,]
R2117	T2199	T2200	nummod	26,]
R2118	T2200	T2196	conj	],]
R2119	T2201	T2200	punct	",",]
R2120	T2202	T2204	nmod	[,]
R2121	T2203	T2204	nummod	27,]
R2122	T2204	T2200	conj	],]
R2123	T2205	T2204	punct	",",]
R2124	T2206	T2208	compound	[,]
R2125	T2207	T2208	compound	28,]
R2126	T2208	T2204	conj	],]
R2127	T2209	T2208	cc	and,]
R2128	T2210	T2211	det	this,increase
R2129	T2211	T2208	conj	increase,]
R2130	T2212	T2215	aux	has,associated
R2131	T2213	T2215	auxpass	been,associated
R2132	T2214	T2215	advmod	temporally,associated
R2133	T2215	T2186	conj	associated,increased
R2134	T2216	T2215	prep	with,associated
R2135	T2217	T2219	det	a,response
R2136	T2218	T2219	amod	clinical,response
R2137	T2219	T2216	pobj	response,with
R2138	T2220	T2219	prep	to,response
R2139	T2221	T2220	pobj	treatment,to
R2140	T2222	T2221	dobj	[,treatment
R2141	T2223	T2224	nummod	21,]
R2142	T2224	T2222	appos	],[
R2143	T2225	T2215	punct	.,associated

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T952	13-19	JJ	denotes	Cystic
T953	20-28	NN	denotes	fibrosis
T954	29-31	VB	denotes	is
T955	32-34	DT	denotes	an
T956	35-44	JJ	denotes	autosomal
T957	45-54	JJ	denotes	recessive
T958	55-62	NN	denotes	disease
T959	63-69	VB	denotes	caused
T960	70-72	IN	denotes	by
T961	73-82	NN	denotes	mutations
T962	83-85	IN	denotes	in
T963	86-89	DT	denotes	the
T964	90-96	JJ	denotes	cystic
T965	97-105	NN	denotes	fibrosis
T966	106-119	JJ	denotes	transmembrane
T967	120-131	NN	denotes	conductance
T968	132-141	NN	denotes	regulator
T969	142-143	-LRB-	denotes	(
T970	143-147	NN	denotes	CFTR
T971	147-148	-RRB-	denotes	)
T972	148-149	-COMMA-	denotes	,
T973	150-155	WDT	denotes	which
T974	156-165	VB	denotes	functions
T975	166-168	IN	denotes	as
T976	169-170	DT	denotes	a
T977	171-179	NN	denotes	chloride
T978	180-183	NN	denotes	ion
T979	184-191	NN	denotes	channel
T980	193-195	NN	denotes	CF
T981	196-203	VB	denotes	remains
T982	204-207	CD	denotes	one
T983	208-210	IN	denotes	of
T984	211-214	DT	denotes	the
T985	215-219	RB	denotes	most
T986	220-226	JJ	denotes	common
T987	227-233	JJ	denotes	lethal
T988	234-241	JJ	denotes	genetic
T989	242-250	NN	denotes	diseases
T990	251-253	IN	denotes	in
T991	254-265	NN	denotes	populations
T992	266-268	IN	denotes	of
T993	269-277	JJ	denotes	European
T994	278-285	NN	denotes	descent
T995	286-290	IN	denotes	with
T996	291-294	DT	denotes	the
T997	295-302	JJ	denotes	current
T998	303-310	JJ	denotes	average
T999	311-319	NN	denotes	lifespan
T1000	320-322	IN	denotes	of
T1001	323-325	NN	denotes	CF
T1002	326-334	NN	denotes	patients
T1003	335-348	RB	denotes	approximately
T1004	349-351	CD	denotes	40
T1005	352-357	NN	denotes	years
T1006	358-360	IN	denotes	of
T1007	361-364	NN	denotes	age
T1008	365-366	-LRB-	denotes	[
T1009	366-367	CD	denotes	1
T1010	367-368	-RRB-	denotes	]
T1011	368-369	-COMMA-	denotes	,
T1012	370-371	-LRB-	denotes	[
T1013	371-372	CD	denotes	2
T1014	372-373	-RRB-	denotes	]
T1015	375-384	JJ	denotes	Recurrent
T1016	385-397	JJ	denotes	inflammatory
T1017	398-407	JJ	denotes	pulmonary
T1018	408-420	NN	denotes	exacerbation
T1019	421-423	VB	denotes	is
T1020	424-427	DT	denotes	the
T1021	428-435	JJ	denotes	primary
T1022	436-441	NN	denotes	cause
T1023	442-444	IN	denotes	of
T1024	445-449	NN	denotes	lung
T1025	450-457	NN	denotes	disease
T1026	458-469	NN	denotes	progression
T1027	470-473	CC	denotes	and
T1028	474-484	RB	denotes	ultimately
T1029	484-485	-COMMA-	denotes	,
T1030	486-491	NN	denotes	death
T1031	492-494	IN	denotes	in
T1032	495-497	NN	denotes	CF
T1033	499-509	VB	denotes	Controlled
T1034	510-522	NN	denotes	inflammation
T1035	523-525	VB	denotes	is
T1036	526-535	JJ	denotes	important
T1037	536-539	IN	denotes	for
T1038	540-548	VB	denotes	fighting
T1039	549-558	NN	denotes	infection
T1040	558-559	-COMMA-	denotes	,
T1041	560-563	CC	denotes	but
T1042	564-566	IN	denotes	in
T1043	567-573	NN	denotes	excess
T1044	573-574	-COMMA-	denotes	,
T1045	575-577	PRP	denotes	it
T1046	578-585	VB	denotes	becomes
T1047	586-597	JJ	denotes	destructive
T1048	598-600	TO	denotes	to
T1049	601-605	NN	denotes	host
T1050	606-611	NN	denotes	cells
T1051	612-615	CC	denotes	and
T1052	616-618	TO	denotes	to
T1053	619-622	DT	denotes	the
T1054	623-635	NN	denotes	architecture
T1055	636-638	IN	denotes	of
T1056	639-642	DT	denotes	the
T1057	643-648	NN	denotes	lungs
T1058	649-650	-LRB-	denotes	[
T1059	650-651	CD	denotes	2
T1060	651-652	-RRB-	denotes	]
T1061	652-653	-COMMA-	denotes	,
T1062	654-655	-LRB-	denotes	[
T1063	655-656	CD	denotes	3
T1064	656-657	-RRB-	denotes	]
T1065	659-661	IN	denotes	In
T1066	662-664	NN	denotes	CF
T1067	664-665	-COMMA-	denotes	,
T1068	666-672	NN	denotes	airway
T1069	673-683	JJ	denotes	epithelial
T1070	684-689	NN	denotes	cells
T1071	690-694	VB	denotes	have
T1072	695-699	VB	denotes	been
T1073	700-705	VB	denotes	shown
T1074	706-708	TO	denotes	to
T1075	709-716	VB	denotes	produce
T1076	717-719	DT	denotes	an
T1077	720-731	JJ	denotes	exaggerated
T1078	732-748	JJ	denotes	pro-inflammatory
T1079	749-757	NN	denotes	cytokine
T1080	758-766	NN	denotes	response
T1081	767-769	TO	denotes	to
T1082	770-781	NN	denotes	stimulation
T1083	782-783	-LRB-	denotes	[
T1084	783-784	CD	denotes	4
T1085	784-785	-RRB-	denotes	]
T1086	785-786	-COMMA-	denotes	,
T1087	787-788	-LRB-	denotes	[
T1088	788-789	CD	denotes	5
T1089	789-790	-RRB-	denotes	]
T1090	792-794	PRP	denotes	It
T1091	795-797	VB	denotes	is
T1092	798-805	JJ	denotes	unclear
T1093	806-813	IN	denotes	whether
T1094	814-818	DT	denotes	this
T1095	819-829	VB	denotes	heightened
T1096	830-842	JJ	denotes	inflammatory
T1097	843-851	NN	denotes	response
T1098	852-854	VB	denotes	is
T1099	855-864	JJ	denotes	intrinsic
T1100	865-867	TO	denotes	to
T1101	868-873	NN	denotes	cells
T1102	874-881	VB	denotes	lacking
T1103	882-886	NN	denotes	CFTR
T1104	887-889	CC	denotes	or
T1105	890-897	IN	denotes	whether
T1106	898-900	PRP	denotes	it
T1107	901-903	VB	denotes	is
T1108	904-905	DT	denotes	a
T1109	906-912	NN	denotes	result
T1110	913-915	IN	denotes	of
T1111	916-923	JJ	denotes	chronic
T1112	924-937	JJ	denotes	polymicrobial
T1113	938-947	NN	denotes	infection
T1114	948-949	-LRB-	denotes	[
T1115	949-950	CD	denotes	6
T1116	950-951	-RRB-	denotes	]
T1117	951-952	-COMMA-	denotes	,
T1118	953-954	-LRB-	denotes	[
T1119	954-955	CD	denotes	7
T1120	955-956	-RRB-	denotes	]
T1121	958-968	RB	denotes	Regardless
T1122	969-971	IN	denotes	of
T1123	972-976	DT	denotes	this
T1124	977-988	NN	denotes	controversy
T1125	988-989	-COMMA-	denotes	,
T1126	990-1001	VB	denotes	identifying
T1127	1002-1005	CC	denotes	and
T1128	1006-1015	VB	denotes	targeting
T1129	1016-1024	JJ	denotes	relevant
T1130	1025-1037	JJ	denotes	inflammatory
T1131	1038-1047	NN	denotes	mediators
T1132	1048-1050	VB	denotes	is
T1133	1051-1052	DT	denotes	a
T1134	1053-1061	JJ	denotes	critical
T1135	1062-1066	NN	denotes	step
T1136	1067-1069	IN	denotes	in
T1137	1070-1080	VB	denotes	developing
T1138	1081-1085	RB	denotes	more
T1139	1086-1094	JJ	denotes	specific
T1140	1095-1106	JJ	denotes	therapeutic
T1141	1107-1117	NN	denotes	approaches
T1142	1118-1120	TO	denotes	to
T1143	1121-1128	VB	denotes	control
T1144	1129-1141	NN	denotes	inflammation
T1145	1142-1145	CC	denotes	and
T1146	1146-1153	VB	denotes	improve
T1147	1154-1160	NN	denotes	health
T1148	1161-1169	NN	denotes	outcomes
T1149	1170-1172	IN	denotes	in
T1150	1173-1175	NN	denotes	CF
T1151	1176-1177	-LRB-	denotes	[
T1152	1177-1178	CD	denotes	8
T1153	1178-1179	-RRB-	denotes	]
T1154	1181-1194	NN	denotes	Interleukin-1
T1155	1195-1199	NN	denotes	beta
T1156	1200-1201	-LRB-	denotes	(
T1157	1201-1206	NN	denotes	IL-1β
T1158	1206-1207	-RRB-	denotes	)
T1159	1208-1210	VB	denotes	is
T1160	1211-1212	DT	denotes	a
T1161	1213-1218	JJ	denotes	major
T1162	1219-1231	JJ	denotes	inflammatory
T1163	1232-1240	NN	denotes	mediator
T1164	1242-1245	PRP-DOLLAR-	denotes	Its
T1165	1246-1259	JJ	denotes	physiological
T1166	1260-1267	NN	denotes	effects
T1167	1268-1271	VB	denotes	are
T1168	1272-1279	JJ	denotes	diverse
T1169	1280-1283	CC	denotes	and
T1170	1284-1295	RB	denotes	potentially
T1171	1296-1305	JJ	denotes	important
T1172	1306-1308	TO	denotes	to
T1173	1309-1312	DT	denotes	the
T1174	1313-1325	NN	denotes	pathogenesis
T1175	1326-1328	IN	denotes	of
T1176	1329-1333	NN	denotes	lung
T1177	1334-1347	NN	denotes	exacerbations
T1178	1348-1350	IN	denotes	in
T1179	1351-1353	NN	denotes	CF
T1180	1353-1354	-COMMA-	denotes	,
T1181	1355-1364	VB	denotes	including
T1182	1365-1368	DT	denotes	the
T1183	1369-1379	NN	denotes	generation
T1184	1380-1382	IN	denotes	of
T1185	1383-1388	NN	denotes	fever
T1186	1388-1389	-COMMA-	denotes	,
T1187	1390-1393	DT	denotes	the
T1188	1394-1405	NN	denotes	recruitment
T1189	1406-1408	IN	denotes	of
T1190	1409-1421	JJ	denotes	inflammatory
T1191	1422-1430	NN	denotes	effector
T1192	1431-1436	NN	denotes	cells
T1193	1436-1437	-COMMA-	denotes	,
T1194	1438-1441	DT	denotes	the
T1195	1442-1451	NN	denotes	induction
T1196	1452-1454	IN	denotes	of
T1197	1455-1460	JJ	denotes	other
T1198	1461-1477	JJ	denotes	pro-inflammatory
T1199	1478-1487	NN	denotes	cytokines
T1200	1488-1492	JJ	denotes	such
T1201	1493-1495	IN	denotes	as
T1202	1496-1500	NN	denotes	IL-6
T1203	1501-1504	CC	denotes	and
T1204	1505-1509	NN	denotes	IL-8
T1205	1509-1510	-COMMA-	denotes	,
T1206	1511-1514	CC	denotes	and
T1207	1515-1518	DT	denotes	the
T1208	1519-1526	NN	denotes	shaping
T1209	1527-1529	IN	denotes	of
T1210	1530-1531	NN	denotes	T
T1211	1532-1536	NN	denotes	cell
T1212	1537-1546	NN	denotes	responses
T1213	1547-1548	-LRB-	denotes	[
T1214	1548-1549	CD	denotes	9
T1215	1549-1550	-RRB-	denotes	]
T1216	1550-1551	-COMMA-	denotes	,
T1217	1552-1553	-LRB-	denotes	[
T1218	1553-1555	CD	denotes	10
T1219	1555-1556	-RRB-	denotes	]
T1220	1558-1567	VB	denotes	Following
T1221	1568-1578	NN	denotes	initiation
T1222	1579-1581	IN	denotes	of
T1223	1582-1585	DT	denotes	the
T1224	1586-1591	NN	denotes	NF-κB
T1225	1592-1601	NN	denotes	signaling
T1226	1602-1609	NN	denotes	cascade
T1227	1609-1610	-COMMA-	denotes	,
T1228	1611-1616	NN	denotes	IL-1β
T1229	1617-1619	VB	denotes	is
T1230	1620-1628	VB	denotes	produced
T1231	1629-1631	IN	denotes	in
T1232	1632-1635	DT	denotes	the
T1233	1636-1643	NN	denotes	cytosol
T1234	1644-1646	IN	denotes	as
T1235	1647-1648	DT	denotes	a
T1236	1649-1661	RB	denotes	biologically
T1237	1662-1670	JJ	denotes	inactive
T1238	1671-1682	JJ	denotes	full-length
T1239	1683-1692	NN	denotes	pro-IL-1β
T1240	1694-1703	NN	denotes	Pro-IL-1β
T1241	1704-1706	VB	denotes	is
T1242	1707-1719	RB	denotes	subsequently
T1243	1720-1729	VB	denotes	converted
T1244	1730-1734	IN	denotes	into
T1245	1735-1738	PRP-DOLLAR-	denotes	its
T1246	1739-1745	JJ	denotes	active
T1247	1746-1750	NN	denotes	form
T1248	1751-1753	IN	denotes	by
T1249	1754-1763	JJ	denotes	cytosolic
T1250	1764-1771	NN	denotes	protein
T1251	1772-1781	NN	denotes	complexes
T1252	1782-1788	VB	denotes	termed
T1253	1789-1805	NN	denotes	“inflammasomes.”
T1254	1806-1819	NN	denotes	Inflammasomes
T1255	1820-1828	NN	denotes	assemble
T1256	1829-1831	IN	denotes	in
T1257	1832-1840	NN	denotes	response
T1258	1841-1843	TO	denotes	to
T1259	1844-1851	JJ	denotes	certain
T1260	1852-1860	JJ	denotes	cellular
T1261	1861-1867	NN	denotes	danger
T1262	1868-1875	NN	denotes	signals
T1263	1876-1879	CC	denotes	and
T1264	1880-1887	VB	denotes	mediate
T1265	1888-1891	DT	denotes	the
T1266	1892-1907	NN	denotes	auto-activation
T1267	1908-1910	IN	denotes	of
T1268	1911-1920	NN	denotes	caspase-1
T1269	1921-1922	-LRB-	denotes	[
T1270	1922-1923	CD	denotes	9
T1271	1923-1924	-RRB-	denotes	]
T1272	1924-1925	-COMMA-	denotes	,
T1273	1926-1927	-LRB-	denotes	[
T1274	1927-1929	CD	denotes	11
T1275	1929-1930	-RRB-	denotes	]
T1276	1930-1931	-COMMA-	denotes	,
T1277	1932-1937	WDT	denotes	which
T1278	1938-1945	VB	denotes	cleaves
T1279	1946-1955	NN	denotes	pro-IL-1β
T1280	1956-1959	CC	denotes	and
T1281	1960-1969	NN	denotes	pro-IL-18
T1282	1970-1974	IN	denotes	into
T1283	1975-1980	PRP-DOLLAR-	denotes	their
T1284	1981-1993	RB	denotes	biologically
T1285	1994-2000	JJ	denotes	active
T1286	2001-2006	NN	denotes	forms
T1287	2007-2010	IN	denotes	for
T1288	2011-2020	NN	denotes	secretion
T1289	2022-2026	CD	denotes	Four
T1290	2027-2035	JJ	denotes	distinct
T1291	2036-2049	NN	denotes	inflammasomes
T1292	2050-2054	VB	denotes	have
T1293	2055-2059	VB	denotes	been
T1294	2060-2070	VB	denotes	recognized
T1295	2072-2077	DT	denotes	These
T1296	2078-2081	VB	denotes	are
T1297	2082-2085	DT	denotes	the
T1298	2086-2091	NN	denotes	NLRP1
T1299	2092-2093	-LRB-	denotes	[
T1300	2093-2095	CD	denotes	12
T1301	2095-2096	-RRB-	denotes	]
T1302	2096-2097	-COMMA-	denotes	,
T1303	2098-2103	NN	denotes	NLRP3
T1304	2104-2105	-LRB-	denotes	[
T1305	2105-2107	CD	denotes	13
T1306	2107-2108	-RRB-	denotes	]
T1307	2108-2109	-COMMA-	denotes	,
T1308	2110-2111	-LRB-	denotes	[
T1309	2111-2113	CD	denotes	14
T1310	2113-2114	-RRB-	denotes	]
T1311	2114-2115	-COMMA-	denotes	,
T1312	2116-2121	NN	denotes	NLRC4
T1313	2122-2123	-LRB-	denotes	[
T1314	2123-2125	CD	denotes	15
T1315	2125-2126	-RRB-	denotes	]
T1316	2126-2127	-COMMA-	denotes	,
T1317	2128-2129	-LRB-	denotes	[
T1318	2129-2131	CD	denotes	16
T1319	2131-2132	-RRB-	denotes	]
T1320	2132-2133	-COMMA-	denotes	,
T1321	2134-2137	CC	denotes	and
T1322	2138-2142	NN	denotes	AIM2
T1323	2143-2156	NN	denotes	inflammasomes
T1324	2157-2158	-LRB-	denotes	[
T1325	2158-2160	CD	denotes	17
T1326	2160-2161	-RRB-	denotes	]
T1327	2161-2162	-COMMA-	denotes	,
T1328	2163-2164	-LRB-	denotes	[
T1329	2164-2166	CD	denotes	18
T1330	2166-2167	-RRB-	denotes	]
T1331	2167-2168	-COMMA-	denotes	,
T1332	2169-2174	WDT	denotes	which
T1333	2175-2182	VB	denotes	respond
T1334	2183-2185	TO	denotes	to
T1335	2186-2187	DT	denotes	a
T1336	2188-2195	NN	denotes	variety
T1337	2196-2198	IN	denotes	of
T1338	2199-2208	JJ	denotes	different
T1339	2209-2218	JJ	denotes	microbial
T1340	2219-2229	NN	denotes	signatures
T1341	2230-2233	CC	denotes	and
T1342	2234-2240	NN	denotes	danger
T1343	2241-2248	NN	denotes	signals
T1344	2249-2250	-LRB-	denotes	[
T1345	2250-2252	CD	denotes	11
T1346	2252-2253	-RRB-	denotes	]
T1347	2255-2257	NNP	denotes	P.
T1348	2258-2268	NNP	denotes	aeruginosa
T1349	2268-2269	-COMMA-	denotes	,
T1350	2270-2273	CD	denotes	one
T1351	2274-2276	IN	denotes	of
T1352	2277-2280	DT	denotes	the
T1353	2281-2285	RB	denotes	most
T1354	2286-2292	JJ	denotes	common
T1355	2293-2296	CC	denotes	and
T1356	2297-2307	RB	denotes	clinically
T1357	2308-2316	JJ	denotes	relevant
T1358	2317-2326	NN	denotes	pathogens
T1359	2327-2332	IN	denotes	among
T1360	2333-2335	NN	denotes	CF
T1361	2336-2344	NN	denotes	patients
T1362	2344-2345	-COMMA-	denotes	,
T1363	2346-2355	VB	denotes	activates
T1364	2356-2359	DT	denotes	the
T1365	2360-2365	NN	denotes	NLRC4
T1366	2366-2378	NN	denotes	inflammasome
T1367	2379-2380	-LRB-	denotes	[
T1368	2380-2382	CD	denotes	19
T1369	2382-2383	-RRB-	denotes	]
T1370	2383-2384	-COMMA-	denotes	,
T1371	2385-2386	-LRB-	denotes	[
T1372	2386-2388	CD	denotes	20
T1373	2388-2389	-RRB-	denotes	]
T1374	2391-2400	NN	denotes	Infection
T1375	2401-2405	IN	denotes	with
T1376	2406-2408	NNP	denotes	P.
T1377	2409-2419	NN	denotes	aeruginosa
T1378	2420-2428	VB	denotes	triggers
T1379	2429-2431	DT	denotes	an
T1380	2432-2440	NN	denotes	increase
T1381	2441-2443	IN	denotes	in
T1382	2444-2450	NN	denotes	levels
T1383	2451-2453	IN	denotes	of
T1384	2454-2459	NN	denotes	IL-1β
T1385	2459-2460	-COMMA-	denotes	,
T1386	2461-2465	NN	denotes	IL-6
T1387	2465-2466	-COMMA-	denotes	,
T1388	2467-2470	CC	denotes	and
T1389	2471-2475	NN	denotes	IL-8
T1390	2476-2478	IN	denotes	in
T1391	2479-2494	JJ	denotes	bronchoalveolar
T1392	2495-2501	NN	denotes	lavage
T1393	2502-2507	NN	denotes	fluid
T1394	2508-2509	-LRB-	denotes	(
T1395	2509-2513	NN	denotes	BALF
T1396	2513-2514	-RRB-	denotes	)
T1397	2515-2519	IN	denotes	from
T1398	2520-2528	NN	denotes	patients
T1399	2529-2533	IN	denotes	with
T1400	2534-2536	NN	denotes	CF
T1401	2537-2538	-LRB-	denotes	[
T1402	2538-2540	CD	denotes	21
T1403	2540-2541	-RRB-	denotes	]
T1404	2543-2555	JJ	denotes	Inflammasome
T1405	2556-2565	NN	denotes	responses
T1406	2566-2572	VB	denotes	depend
T1407	2573-2575	IN	denotes	on
T1408	2576-2581	NN	denotes	NF-κB
T1409	2582-2591	NN	denotes	signaling
T1410	2591-2592	-COMMA-	denotes	,
T1411	2593-2598	WRB	denotes	where
T1412	2599-2604	NN	denotes	NF-κB
T1413	2605-2607	VB	denotes	is
T1414	2608-2617	JJ	denotes	important
T1415	2618-2620	IN	denotes	in
T1416	2621-2625	CC	denotes	both
T1417	2626-2629	DT	denotes	the
T1418	2630-2642	NN	denotes	upregulation
T1419	2643-2645	IN	denotes	of
T1420	2646-2654	JJ	denotes	specific
T1421	2655-2667	JJ	denotes	inflammasome
T1422	2668-2678	NN	denotes	components
T1423	2679-2680	-LRB-	denotes	[
T1424	2680-2682	CD	denotes	22
T1425	2682-2683	-RRB-	denotes	]
T1426	2683-2684	-COMMA-	denotes	,
T1427	2685-2686	-LRB-	denotes	[
T1428	2686-2688	CD	denotes	23
T1429	2688-2689	-RRB-	denotes	]
T1430	2689-2690	-COMMA-	denotes	,
T1431	2691-2693	RB	denotes	as
T1432	2694-2698	RB	denotes	well
T1433	2699-2701	IN	denotes	as
T1434	2702-2707	NN	denotes	IL-1β
T1435	2708-2718	NN	denotes	expression
T1436	2719-2720	-LRB-	denotes	[
T1437	2720-2722	CD	denotes	24
T1438	2722-2723	-RRB-	denotes	]
T1439	2723-2724	-COMMA-	denotes	,
T1440	2725-2726	-LRB-	denotes	[
T1441	2726-2728	CD	denotes	25
T1442	2728-2729	-RRB-	denotes	]
T1443	2731-2739	JJ	denotes	Previous
T1444	2740-2747	NN	denotes	studies
T1445	2748-2755	VB	denotes	support
T1446	2756-2757	DT	denotes	a
T1447	2758-2762	NN	denotes	role
T1448	2763-2766	IN	denotes	for
T1449	2767-2772	NN	denotes	IL-1β
T1450	2773-2775	IN	denotes	in
T1451	2776-2779	DT	denotes	the
T1452	2780-2792	NN	denotes	pathogenesis
T1453	2793-2795	IN	denotes	of
T1454	2796-2798	NN	denotes	CF
T1455	2799-2811	JJ	denotes	inflammatory
T1456	2812-2816	NN	denotes	lung
T1457	2817-2824	NN	denotes	disease
T1458	2826-2832	NN	denotes	Levels
T1459	2833-2835	IN	denotes	of
T1460	2836-2841	NN	denotes	IL-1β
T1461	2842-2845	VB	denotes	are
T1462	2846-2855	VB	denotes	increased
T1463	2856-2858	IN	denotes	in
T1464	2859-2863	NN	denotes	BALF
T1465	2864-2868	IN	denotes	from
T1466	2869-2871	NN	denotes	CF
T1467	2872-2880	NN	denotes	patients
T1468	2881-2885	IN	denotes	with
T1469	2886-2895	NN	denotes	infection
T1470	2896-2897	-LRB-	denotes	[
T1471	2897-2899	CD	denotes	21
T1472	2899-2900	-RRB-	denotes	]
T1473	2900-2901	-COMMA-	denotes	,
T1474	2902-2903	-LRB-	denotes	[
T1475	2903-2905	CD	denotes	26
T1476	2905-2906	-RRB-	denotes	]
T1477	2906-2907	-COMMA-	denotes	,
T1478	2908-2909	-LRB-	denotes	[
T1479	2909-2911	CD	denotes	27
T1480	2911-2912	-RRB-	denotes	]
T1481	2912-2913	-COMMA-	denotes	,
T1482	2914-2915	-LRB-	denotes	[
T1483	2915-2917	CD	denotes	28
T1484	2917-2918	-RRB-	denotes	]
T1485	2919-2922	CC	denotes	and
T1486	2923-2927	DT	denotes	this
T1487	2928-2936	NN	denotes	increase
T1488	2937-2940	VB	denotes	has
T1489	2941-2945	VB	denotes	been
T1490	2946-2956	RB	denotes	temporally
T1491	2957-2967	VB	denotes	associated
T1492	2968-2972	IN	denotes	with
T1493	2973-2974	DT	denotes	a
T1494	2975-2983	JJ	denotes	clinical
T1495	2984-2992	NN	denotes	response
T1496	2993-2995	TO	denotes	to
T1497	2996-3005	NN	denotes	treatment
T1498	3006-3007	-LRB-	denotes	[
T1499	3007-3009	CD	denotes	21
T1500	3009-3010	-RRB-	denotes	]
T1501	3012-3025	NN	denotes	Polymorphisms
T1502	3026-3028	IN	denotes	in
T1503	3029-3032	DT	denotes	the
T1504	3033-3037	NN	denotes	IL1B
T1505	3038-3042	NN	denotes	gene
T1506	3043-3047	VB	denotes	have
T1507	3048-3052	RB	denotes	also
T1508	3053-3057	VB	denotes	been
T1509	3058-3068	VB	denotes	associated
T1510	3069-3073	IN	denotes	with
T1511	3074-3081	VB	denotes	varying
T1512	3082-3089	NN	denotes	degrees
T1513	3090-3092	IN	denotes	of
T1514	3093-3100	NN	denotes	disease
T1515	3101-3109	NN	denotes	severity
T1516	3110-3112	IN	denotes	in
T1517	3113-3115	NN	denotes	CF
T1518	3116-3124	NN	denotes	patients
T1519	3125-3126	-LRB-	denotes	[
T1520	3126-3128	CD	denotes	29
T1521	3128-3129	-RRB-	denotes	]
T1522	3131-3137	JJ	denotes	Murine
T1523	3138-3144	NN	denotes	models
T1524	3145-3147	IN	denotes	of
T1525	3148-3152	NN	denotes	CFTR
T1526	3153-3164	NN	denotes	dysfunction
T1527	3165-3169	VB	denotes	have
T1528	3170-3179	VB	denotes	exhibited
T1529	3180-3191	JJ	denotes	significant
T1530	3192-3201	NN	denotes	increases
T1531	3202-3204	IN	denotes	in
T1532	3205-3210	NN	denotes	IL-1β
T1533	3211-3221	NN	denotes	expression
T1534	3222-3224	CC	denotes	or
T1535	3225-3234	NN	denotes	secretion
T1536	3235-3237	IN	denotes	in
T1537	3238-3249	NN	denotes	macrophages
T1538	3250-3251	-LRB-	denotes	[
T1539	3251-3253	CD	denotes	30
T1540	3253-3254	-RRB-	denotes	]
T1541	3254-3255	-COMMA-	denotes	,
T1542	3256-3257	-LRB-	denotes	[
T1543	3257-3259	CD	denotes	31
T1544	3259-3260	-RRB-	denotes	]
T1545	3260-3261	-COMMA-	denotes	,
T1546	3262-3265	CC	denotes	and
T1547	3266-3273	VB	denotes	support
T1548	3274-3277	DT	denotes	the
T1549	3278-3288	NN	denotes	hypothesis
T1550	3289-3293	IN	denotes	that
T1551	3294-3297	DT	denotes	the
T1552	3298-3302	NN	denotes	loss
T1553	3303-3305	IN	denotes	of
T1554	3306-3310	NN	denotes	CFTR
T1555	3311-3320	VB	denotes	increases
T1556	3321-3326	NN	denotes	NF-κB
T1557	3327-3337	NN	denotes	activation
T1558	3338-3343	IN	denotes	under
T1559	3344-3349	JJ	denotes	basal
T1560	3350-3353	CC	denotes	and
T1561	3354-3365	JJ	denotes	stimulatory
T1562	3366-3376	NN	denotes	conditions
T1563	3377-3378	-LRB-	denotes	[
T1564	3378-3379	CD	denotes	4
T1565	3379-3380	-RRB-	denotes	]
T1566	3380-3381	-COMMA-	denotes	,
T1567	3382-3383	-LRB-	denotes	[
T1568	3383-3384	CD	denotes	5
T1569	3384-3385	-RRB-	denotes	]
T1570	3385-3386	-COMMA-	denotes	,
T1571	3387-3388	-LRB-	denotes	[
T1572	3388-3390	CD	denotes	32
T1573	3390-3391	-RRB-	denotes	]
T1574	3391-3392	-COMMA-	denotes	,
T1575	3393-3394	-LRB-	denotes	[
T1576	3394-3396	CD	denotes	33
T1577	3396-3397	-RRB-	denotes	]
T1578	3399-3406	RB	denotes	Finally
T1579	3406-3407	-COMMA-	denotes	,
T1580	3408-3419	NN	denotes	replacement
T1581	3420-3422	IN	denotes	of
T1582	3423-3431	NN	denotes	chloride
T1583	3432-3436	NN	denotes	ions
T1584	3437-3441	IN	denotes	with
T1585	3442-3451	NN	denotes	glutamate
T1586	3452-3454	CC	denotes	or
T1587	3455-3464	NN	denotes	gluconate
T1588	3465-3467	IN	denotes	in
T1589	3468-3472	NN	denotes	cell
T1590	3473-3480	NN	denotes	culture
T1591	3481-3486	NN	denotes	media
T1592	3487-3496	VB	denotes	increases
T1593	3497-3506	NN	denotes	secretion
T1594	3507-3509	IN	denotes	of
T1595	3510-3515	NN	denotes	IL-1β
T1596	3516-3518	IN	denotes	in
T1597	3519-3527	NN	denotes	response
T1598	3528-3530	TO	denotes	to
T1599	3531-3536	NN	denotes	NLRP3
T1600	3537-3548	NN	denotes	stimulation
T1601	3549-3551	IN	denotes	by
T1602	3552-3561	NN	denotes	adenosine
T1603	3562-3574	NN	denotes	triphosphate
T1604	3575-3576	-LRB-	denotes	(
T1605	3576-3579	NN	denotes	ATP
T1606	3579-3580	-RRB-	denotes	)
T1607	3581-3582	-LRB-	denotes	[
T1608	3582-3584	CD	denotes	34
T1609	3584-3585	-RRB-	denotes	]
T1610	3585-3586	-COMMA-	denotes	,
T1611	3587-3595	VB	denotes	implying
T1612	3596-3598	DT	denotes	an
T1613	3599-3609	JJ	denotes	inhibitory
T1614	3610-3614	NN	denotes	role
T1615	3615-3618	IN	denotes	for
T1616	3619-3632	JJ	denotes	extracellular
T1617	3633-3641	NN	denotes	chloride
T1618	3642-3644	IN	denotes	in
T1619	3645-3650	NN	denotes	NLRP3
T1620	3651-3661	NN	denotes	activation
T1621	3663-3668	VB	denotes	Taken
T1622	3669-3677	RB	denotes	together
T1623	3677-3678	-COMMA-	denotes	,
T1624	3679-3684	DT	denotes	these
T1625	3685-3689	NN	denotes	data
T1626	3690-3699	VB	denotes	implicate
T1627	3700-3703	DT	denotes	the
T1628	3704-3715	NN	denotes	involvement
T1629	3716-3718	IN	denotes	of
T1630	3719-3724	NN	denotes	IL-1β
T1631	3725-3728	CC	denotes	and
T1632	3729-3741	RB	denotes	consequently
T1633	3741-3742	-COMMA-	denotes	,
T1634	3743-3746	DT	denotes	the
T1635	3747-3760	NN	denotes	inflammasomes
T1636	3760-3761	-COMMA-	denotes	,
T1637	3762-3764	IN	denotes	in
T1638	3765-3767	NN	denotes	CF
T1639	3768-3780	JJ	denotes	inflammatory
T1640	3781-3788	NN	denotes	disease
R736	T953	T952	arg1Of	fibrosis,Cystic
R737	T953	T954	arg1Of	fibrosis,is
R738	T958	T954	arg2Of	disease,is
R739	T958	T955	arg1Of	disease,an
R740	T958	T956	arg1Of	disease,autosomal
R741	T958	T957	arg1Of	disease,recessive
R742	T958	T959	arg2Of	disease,caused
R743	T961	T959	arg1Of	mutations,caused
R744	T961	T960	arg2Of	mutations,by
R745	T961	T962	arg1Of	mutations,in
R746	T968	T962	arg2Of	regulator,in
R747	T968	T963	arg1Of	regulator,the
R748	T968	T964	arg1Of	regulator,cystic
R749	T968	T965	arg1Of	regulator,fibrosis
R750	T968	T966	arg1Of	regulator,transmembrane
R751	T968	T967	arg1Of	regulator,conductance
R752	T968	T969	arg1Of	regulator,(
R753	T968	T972	arg1Of	regulator,","
R754	T968	T973	arg1Of	regulator,which
R755	T968	T974	arg1Of	regulator,functions
R756	T970	T969	arg2Of	CFTR,(
R757	T971	T969	arg3Of	),(
R758	T974	T975	arg1Of	functions,as
R759	T979	T975	arg2Of	channel,as
R760	T979	T976	arg1Of	channel,a
R761	T979	T977	arg1Of	channel,chloride
R762	T979	T978	arg1Of	channel,ion
R763	T980	T981	arg1Of	CF,remains
R764	T981	T1008	arg1Of	remains,[
R765	T981	T1011	arg1Of	remains,","
R766	T981	T1012	arg1Of	remains,[
R767	T982	T981	arg2Of	one,remains
R768	T982	T983	arg1Of	one,of
R769	T982	T990	arg1Of	one,in
R770	T986	T985	arg1Of	common,most
R771	T989	T983	arg2Of	diseases,of
R772	T989	T984	arg1Of	diseases,the
R773	T989	T986	arg1Of	diseases,common
R774	T989	T987	arg1Of	diseases,lethal
R775	T989	T988	arg1Of	diseases,genetic
R776	T991	T990	arg2Of	populations,in
R777	T991	T992	arg1Of	populations,of
R778	T991	T995	arg1Of	populations,with
R779	T991	T1003	arg1Of	populations,approximately
R780	T994	T992	arg2Of	descent,of
R781	T994	T993	arg1Of	descent,European
R782	T999	T995	arg2Of	lifespan,with
R783	T999	T996	arg1Of	lifespan,the
R784	T999	T997	arg1Of	lifespan,current
R785	T999	T998	arg1Of	lifespan,average
R786	T999	T1000	arg1Of	lifespan,of
R787	T1002	T1000	arg2Of	patients,of
R788	T1002	T1001	arg1Of	patients,CF
R789	T1003	T1005	arg1Of	approximately,years
R790	T1005	T1004	arg1Of	years,40
R791	T1005	T1006	arg1Of	years,of
R792	T1007	T1006	arg2Of	age,of
R793	T1009	T1008	arg2Of	1,[
R794	T1010	T1008	arg3Of	],[
R795	T1013	T1012	arg2Of	2,[
R796	T1014	T1012	arg3Of	],[
R797	T1018	T1015	arg1Of	exacerbation,Recurrent
R798	T1018	T1016	arg1Of	exacerbation,inflammatory
R799	T1018	T1017	arg1Of	exacerbation,pulmonary
R800	T1018	T1019	arg1Of	exacerbation,is
R801	T1022	T1021	arg1Of	cause,primary
R802	T1022	T1023	arg1Of	cause,of
R803	T1022	T1028	arg1Of	cause,ultimately
R804	T1022	T1029	arg1Of	cause,","
R805	T1023	T1027	arg1Of	of,and
R806	T1026	T1023	arg2Of	progression,of
R807	T1026	T1024	arg1Of	progression,lung
R808	T1026	T1025	arg1Of	progression,disease
R809	T1028	T1027	arg2Of	ultimately,and
R810	T1029	T1019	arg2Of	",",is
R811	T1029	T1020	arg1Of	",",the
R812	T1029	T1031	arg1Of	",",in
R813	T1030	T1029	arg2Of	death,","
R814	T1032	T1031	arg2Of	CF,in
R815	T1034	T1033	arg2Of	inflammation,Controlled
R816	T1034	T1035	arg1Of	inflammation,is
R817	T1034	T1036	arg1Of	inflammation,important
R818	T1035	T1041	arg1Of	is,but
R819	T1036	T1035	arg2Of	important,is
R820	T1036	T1037	arg1Of	important,for
R821	T1038	T1037	arg2Of	fighting,for
R822	T1039	T1038	arg2Of	infection,fighting
R823	T1041	T1040	arg1Of	but,","
R824	T1043	T1042	arg2Of	excess,in
R825	T1045	T1046	arg1Of	it,becomes
R826	T1045	T1047	arg1Of	it,destructive
R827	T1046	T1041	arg2Of	becomes,but
R828	T1046	T1042	arg1Of	becomes,in
R829	T1046	T1044	arg1Of	becomes,","
R830	T1046	T1061	arg1Of	becomes,","
R831	T1046	T1062	arg1Of	becomes,[
R832	T1047	T1046	arg2Of	destructive,becomes
R833	T1047	T1048	arg1Of	destructive,to
R834	T1047	T1052	arg1Of	destructive,to
R835	T1048	T1051	arg1Of	to,and
R836	T1050	T1048	arg2Of	cells,to
R837	T1050	T1049	arg1Of	cells,host
R838	T1052	T1051	arg2Of	to,and
R839	T1054	T1052	arg2Of	architecture,to
R840	T1054	T1053	arg1Of	architecture,the
R841	T1054	T1055	arg1Of	architecture,of
R842	T1057	T1055	arg2Of	lungs,of
R843	T1057	T1056	arg1Of	lungs,the
R844	T1057	T1058	arg1Of	lungs,[
R845	T1059	T1058	arg2Of	2,[
R846	T1060	T1058	arg3Of	],[
R847	T1063	T1062	arg2Of	3,[
R848	T1064	T1062	arg3Of	],[
R849	T1066	T1065	arg2Of	CF,In
R850	T1070	T1068	arg1Of	cells,airway
R851	T1070	T1069	arg1Of	cells,epithelial
R852	T1070	T1071	arg1Of	cells,have
R853	T1070	T1072	arg1Of	cells,been
R854	T1070	T1073	arg2Of	cells,shown
R855	T1070	T1075	arg1Of	cells,produce
R856	T1073	T1065	arg1Of	shown,In
R857	T1073	T1067	arg1Of	shown,","
R858	T1073	T1071	arg2Of	shown,have
R859	T1073	T1072	arg2Of	shown,been
R860	T1075	T1073	arg3Of	produce,shown
R861	T1075	T1074	arg1Of	produce,to
R862	T1075	T1086	arg1Of	produce,","
R863	T1075	T1087	arg1Of	produce,[
R864	T1080	T1075	arg2Of	response,produce
R865	T1080	T1076	arg1Of	response,an
R866	T1080	T1077	arg1Of	response,exaggerated
R867	T1080	T1078	arg1Of	response,pro-inflammatory
R868	T1080	T1079	arg1Of	response,cytokine
R869	T1080	T1081	arg1Of	response,to
R870	T1082	T1081	arg2Of	stimulation,to
R871	T1082	T1083	arg1Of	stimulation,[
R872	T1084	T1083	arg2Of	4,[
R873	T1085	T1083	arg3Of	],[
R874	T1088	T1087	arg2Of	5,[
R875	T1089	T1087	arg3Of	],[
R876	T1092	T1091	arg2Of	unclear,is
R877	T1097	T1094	arg1Of	response,this
R878	T1097	T1095	arg2Of	response,heightened
R879	T1097	T1096	arg1Of	response,inflammatory
R880	T1097	T1098	arg1Of	response,is
R881	T1097	T1099	arg1Of	response,intrinsic
R882	T1098	T1093	arg1Of	is,whether
R883	T1098	T1104	arg1Of	is,or
R884	T1099	T1098	arg2Of	intrinsic,is
R885	T1099	T1100	arg1Of	intrinsic,to
R886	T1101	T1100	arg2Of	cells,to
R887	T1101	T1102	arg1Of	cells,lacking
R888	T1103	T1102	arg2Of	CFTR,lacking
R889	T1104	T1090	arg1Of	or,It
R890	T1104	T1091	arg1Of	or,is
R891	T1104	T1092	arg1Of	or,unclear
R892	T1105	T1104	arg2Of	whether,or
R893	T1106	T1107	arg1Of	it,is
R894	T1107	T1105	arg2Of	is,whether
R895	T1109	T1107	arg2Of	result,is
R896	T1109	T1108	arg1Of	result,a
R897	T1109	T1110	arg1Of	result,of
R898	T1113	T1110	arg2Of	infection,of
R899	T1113	T1111	arg1Of	infection,chronic
R900	T1113	T1112	arg1Of	infection,polymicrobial
R901	T1113	T1114	arg1Of	infection,[
R902	T1113	T1117	arg1Of	infection,","
R903	T1113	T1118	arg1Of	infection,[
R904	T1115	T1114	arg2Of	6,[
R905	T1116	T1114	arg3Of	],[
R906	T1119	T1118	arg2Of	7,[
R907	T1120	T1118	arg3Of	],[
R908	T1121	T1122	arg1Of	Regardless,of
R909	T1124	T1122	arg2Of	controversy,of
R910	T1124	T1123	arg1Of	controversy,this
R911	T1126	T1127	arg1Of	identifying,and
R912	T1127	T1121	arg1Of	and,Regardless
R913	T1127	T1125	arg1Of	and,","
R914	T1127	T1132	arg2Of	and,is
R915	T1128	T1127	arg2Of	targeting,and
R916	T1131	T1126	arg2Of	mediators,identifying
R917	T1131	T1128	arg2Of	mediators,targeting
R918	T1131	T1129	arg1Of	mediators,relevant
R919	T1131	T1130	arg1Of	mediators,inflammatory
R920	T1135	T1126	arg1Of	step,identifying
R921	T1135	T1128	arg1Of	step,targeting
R922	T1135	T1132	arg1Of	step,is
R923	T1135	T1133	arg1Of	step,a
R924	T1135	T1134	arg1Of	step,critical
R925	T1135	T1136	arg1Of	step,in
R926	T1137	T1136	arg2Of	developing,in
R927	T1137	T1142	modOf	developing,to
R928	T1137	T1149	arg1Of	developing,in
R929	T1137	T1151	arg1Of	developing,[
R930	T1140	T1139	arg1Of	therapeutic,specific
R931	T1141	T1137	arg2Of	approaches,developing
R932	T1141	T1138	arg1Of	approaches,more
R933	T1141	T1140	arg1Of	approaches,therapeutic
R934	T1143	T1145	arg1Of	control,and
R935	T1144	T1143	arg2Of	inflammation,control
R936	T1145	T1142	arg1Of	and,to
R937	T1146	T1145	arg2Of	improve,and
R938	T1148	T1146	arg2Of	outcomes,improve
R939	T1148	T1147	arg1Of	outcomes,health
R940	T1150	T1149	arg2Of	CF,in
R941	T1152	T1151	arg2Of	8,[
R942	T1153	T1151	arg3Of	],[
R943	T1155	T1154	arg1Of	beta,Interleukin-1
R944	T1155	T1156	arg1Of	beta,(
R945	T1155	T1159	arg1Of	beta,is
R946	T1157	T1156	arg2Of	IL-1β,(
R947	T1158	T1156	arg3Of	),(
R948	T1163	T1159	arg2Of	mediator,is
R949	T1163	T1160	arg1Of	mediator,a
R950	T1163	T1161	arg1Of	mediator,major
R951	T1163	T1162	arg1Of	mediator,inflammatory
R952	T1166	T1164	arg1Of	effects,Its
R953	T1166	T1165	arg1Of	effects,physiological
R954	T1166	T1167	arg1Of	effects,are
R955	T1166	T1168	arg1Of	effects,diverse
R956	T1166	T1171	arg1Of	effects,important
R957	T1168	T1169	arg1Of	diverse,and
R958	T1169	T1167	arg2Of	and,are
R959	T1171	T1169	arg2Of	important,and
R960	T1171	T1170	arg1Of	important,potentially
R961	T1171	T1172	arg1Of	important,to
R962	T1174	T1172	arg2Of	pathogenesis,to
R963	T1174	T1173	arg1Of	pathogenesis,the
R964	T1174	T1175	arg1Of	pathogenesis,of
R965	T1177	T1175	arg2Of	exacerbations,of
R966	T1177	T1176	arg1Of	exacerbations,lung
R967	T1177	T1178	arg1Of	exacerbations,in
R968	T1177	T1180	arg1Of	exacerbations,","
R969	T1177	T1181	arg1Of	exacerbations,including
R970	T1179	T1178	arg2Of	CF,in
R971	T1183	T1182	arg1Of	generation,the
R972	T1183	T1184	arg1Of	generation,of
R973	T1183	T1186	arg1Of	generation,","
R974	T1183	T1193	arg1Of	generation,","
R975	T1185	T1184	arg2Of	fever,of
R976	T1188	T1186	arg2Of	recruitment,","
R977	T1188	T1187	arg1Of	recruitment,the
R978	T1188	T1189	arg1Of	recruitment,of
R979	T1192	T1189	arg2Of	cells,of
R980	T1192	T1190	arg1Of	cells,inflammatory
R981	T1192	T1191	arg1Of	cells,effector
R982	T1193	T1206	arg1Of	",",and
R983	T1195	T1193	arg2Of	induction,","
R984	T1195	T1194	arg1Of	induction,the
R985	T1195	T1196	arg1Of	induction,of
R986	T1199	T1196	arg2Of	cytokines,of
R987	T1199	T1197	arg1Of	cytokines,other
R988	T1199	T1198	arg1Of	cytokines,pro-inflammatory
R989	T1199	T1201	arg1Of	cytokines,as
R990	T1201	T1200	arg1Of	as,such
R991	T1202	T1203	arg1Of	IL-6,and
R992	T1203	T1201	arg2Of	and,as
R993	T1204	T1203	arg2Of	IL-8,and
R994	T1206	T1181	arg2Of	and,including
R995	T1206	T1205	arg1Of	and,","
R996	T1208	T1206	arg2Of	shaping,and
R997	T1208	T1207	arg1Of	shaping,the
R998	T1208	T1209	arg1Of	shaping,of
R999	T1212	T1209	arg2Of	responses,of
R1000	T1212	T1210	arg1Of	responses,T
R1001	T1212	T1211	arg1Of	responses,cell
R1002	T1212	T1213	arg1Of	responses,[
R1003	T1212	T1216	arg1Of	responses,","
R1004	T1212	T1217	arg1Of	responses,[
R1005	T1214	T1213	arg2Of	9,[
R1006	T1215	T1213	arg3Of	],[
R1007	T1218	T1217	arg2Of	10,[
R1008	T1219	T1217	arg3Of	],[
R1009	T1221	T1220	arg2Of	initiation,Following
R1010	T1221	T1222	arg1Of	initiation,of
R1011	T1226	T1222	arg2Of	cascade,of
R1012	T1226	T1223	arg1Of	cascade,the
R1013	T1226	T1224	arg1Of	cascade,NF-κB
R1014	T1226	T1225	arg1Of	cascade,signaling
R1015	T1228	T1229	arg1Of	IL-1β,is
R1016	T1228	T1230	arg2Of	IL-1β,produced
R1017	T1230	T1220	arg1Of	produced,Following
R1018	T1230	T1227	arg1Of	produced,","
R1019	T1230	T1229	arg2Of	produced,is
R1020	T1230	T1231	arg1Of	produced,in
R1021	T1230	T1234	arg1Of	produced,as
R1022	T1233	T1231	arg2Of	cytosol,in
R1023	T1233	T1232	arg1Of	cytosol,the
R1024	T1239	T1234	arg2Of	pro-IL-1β,as
R1025	T1239	T1235	arg1Of	pro-IL-1β,a
R1026	T1239	T1236	arg1Of	pro-IL-1β,biologically
R1027	T1239	T1237	arg1Of	pro-IL-1β,inactive
R1028	T1239	T1238	arg1Of	pro-IL-1β,full-length
R1029	T1240	T1241	arg1Of	Pro-IL-1β,is
R1030	T1240	T1243	arg2Of	Pro-IL-1β,converted
R1031	T1240	T1264	arg1Of	Pro-IL-1β,mediate
R1032	T1243	T1241	arg2Of	converted,is
R1033	T1243	T1242	arg1Of	converted,subsequently
R1034	T1243	T1244	arg1Of	converted,into
R1035	T1243	T1263	arg1Of	converted,and
R1036	T1247	T1244	arg2Of	form,into
R1037	T1247	T1245	arg1Of	form,its
R1038	T1247	T1246	arg1Of	form,active
R1039	T1251	T1243	arg1Of	complexes,converted
R1040	T1251	T1248	arg2Of	complexes,by
R1041	T1251	T1249	arg1Of	complexes,cytosolic
R1042	T1251	T1250	arg1Of	complexes,protein
R1043	T1251	T1252	arg2Of	complexes,termed
R1044	T1252	T1256	arg1Of	termed,in
R1045	T1255	T1252	arg3Of	assemble,termed
R1046	T1255	T1253	arg1Of	assemble,“inflammasomes.”
R1047	T1255	T1254	arg1Of	assemble,Inflammasomes
R1048	T1257	T1256	arg2Of	response,in
R1049	T1257	T1258	arg1Of	response,to
R1050	T1262	T1258	arg2Of	signals,to
R1051	T1262	T1259	arg1Of	signals,certain
R1052	T1262	T1260	arg1Of	signals,cellular
R1053	T1262	T1261	arg1Of	signals,danger
R1054	T1264	T1263	arg2Of	mediate,and
R1055	T1266	T1264	arg2Of	auto-activation,mediate
R1056	T1266	T1265	arg1Of	auto-activation,the
R1057	T1266	T1267	arg1Of	auto-activation,of
R1058	T1266	T1273	arg1Of	auto-activation,[
R1059	T1266	T1276	arg1Of	auto-activation,","
R1060	T1266	T1277	arg1Of	auto-activation,which
R1061	T1266	T1278	arg1Of	auto-activation,cleaves
R1062	T1268	T1267	arg2Of	caspase-1,of
R1063	T1268	T1269	arg1Of	caspase-1,[
R1064	T1268	T1272	arg1Of	caspase-1,","
R1065	T1270	T1269	arg2Of	9,[
R1066	T1271	T1269	arg3Of	],[
R1067	T1274	T1273	arg2Of	11,[
R1068	T1275	T1273	arg3Of	],[
R1069	T1279	T1280	arg1Of	pro-IL-1β,and
R1070	T1280	T1278	arg2Of	and,cleaves
R1071	T1280	T1282	arg1Of	and,into
R1072	T1281	T1280	arg2Of	pro-IL-18,and
R1073	T1285	T1284	arg1Of	active,biologically
R1074	T1286	T1282	arg2Of	forms,into
R1075	T1286	T1283	arg1Of	forms,their
R1076	T1286	T1285	arg1Of	forms,active
R1077	T1286	T1287	arg1Of	forms,for
R1078	T1288	T1287	arg2Of	secretion,for
R1079	T1291	T1289	arg1Of	inflammasomes,Four
R1080	T1291	T1290	arg1Of	inflammasomes,distinct
R1081	T1291	T1292	arg1Of	inflammasomes,have
R1082	T1291	T1293	arg1Of	inflammasomes,been
R1083	T1291	T1294	arg2Of	inflammasomes,recognized
R1084	T1294	T1292	arg2Of	recognized,have
R1085	T1294	T1293	arg2Of	recognized,been
R1086	T1295	T1296	arg1Of	These,are
R1087	T1298	T1299	arg1Of	NLRP1,[
R1088	T1298	T1302	arg1Of	NLRP1,","
R1089	T1300	T1299	arg2Of	12,[
R1090	T1301	T1299	arg3Of	],[
R1091	T1302	T1297	arg1Of	",",the
R1092	T1302	T1307	arg1Of	",",","
R1093	T1302	T1308	arg1Of	",",[
R1094	T1302	T1311	arg1Of	",",","
R1095	T1303	T1302	arg2Of	NLRP3,","
R1096	T1303	T1304	arg1Of	NLRP3,[
R1097	T1305	T1304	arg2Of	13,[
R1098	T1306	T1304	arg3Of	],[
R1099	T1309	T1308	arg2Of	14,[
R1100	T1310	T1308	arg3Of	],[
R1101	T1311	T1317	arg1Of	",",[
R1102	T1311	T1321	arg1Of	",",and
R1103	T1312	T1311	arg2Of	NLRC4,","
R1104	T1312	T1313	arg1Of	NLRC4,[
R1105	T1312	T1316	arg1Of	NLRC4,","
R1106	T1314	T1313	arg2Of	15,[
R1107	T1315	T1313	arg3Of	],[
R1108	T1318	T1317	arg2Of	16,[
R1109	T1319	T1317	arg3Of	],[
R1110	T1321	T1296	arg2Of	and,are
R1111	T1321	T1320	arg1Of	and,","
R1112	T1323	T1321	arg2Of	inflammasomes,and
R1113	T1323	T1322	arg1Of	inflammasomes,AIM2
R1114	T1323	T1324	arg1Of	inflammasomes,[
R1115	T1323	T1327	arg1Of	inflammasomes,","
R1116	T1323	T1328	arg1Of	inflammasomes,[
R1117	T1323	T1331	arg1Of	inflammasomes,","
R1118	T1323	T1332	arg1Of	inflammasomes,which
R1119	T1323	T1333	arg1Of	inflammasomes,respond
R1120	T1325	T1324	arg2Of	17,[
R1121	T1326	T1324	arg3Of	],[
R1122	T1329	T1328	arg2Of	18,[
R1123	T1330	T1328	arg3Of	],[
R1124	T1333	T1334	arg1Of	respond,to
R1125	T1336	T1334	arg2Of	variety,to
R1126	T1336	T1335	arg1Of	variety,a
R1127	T1336	T1337	arg1Of	variety,of
R1128	T1340	T1338	arg1Of	signatures,different
R1129	T1340	T1339	arg1Of	signatures,microbial
R1130	T1340	T1341	arg1Of	signatures,and
R1131	T1341	T1337	arg2Of	and,of
R1132	T1343	T1341	arg2Of	signals,and
R1133	T1343	T1342	arg1Of	signals,danger
R1134	T1343	T1344	arg1Of	signals,[
R1135	T1345	T1344	arg2Of	11,[
R1136	T1346	T1344	arg3Of	],[
R1137	T1348	T1347	arg1Of	aeruginosa,P.
R1138	T1348	T1349	arg1Of	aeruginosa,","
R1139	T1348	T1363	arg1Of	aeruginosa,activates
R1140	T1350	T1349	arg2Of	one,","
R1141	T1350	T1351	arg1Of	one,of
R1142	T1350	T1359	arg1Of	one,among
R1143	T1354	T1353	arg1Of	common,most
R1144	T1354	T1355	arg1Of	common,and
R1145	T1357	T1355	arg2Of	relevant,and
R1146	T1357	T1356	arg1Of	relevant,clinically
R1147	T1358	T1351	arg2Of	pathogens,of
R1148	T1358	T1352	arg1Of	pathogens,the
R1149	T1358	T1354	arg1Of	pathogens,common
R1150	T1358	T1357	arg1Of	pathogens,relevant
R1151	T1361	T1359	arg2Of	patients,among
R1152	T1361	T1360	arg1Of	patients,CF
R1153	T1363	T1362	arg1Of	activates,","
R1154	T1363	T1370	arg1Of	activates,","
R1155	T1363	T1371	arg1Of	activates,[
R1156	T1366	T1363	arg2Of	inflammasome,activates
R1157	T1366	T1364	arg1Of	inflammasome,the
R1158	T1366	T1365	arg1Of	inflammasome,NLRC4
R1159	T1366	T1367	arg1Of	inflammasome,[
R1160	T1368	T1367	arg2Of	19,[
R1161	T1369	T1367	arg3Of	],[
R1162	T1372	T1371	arg2Of	20,[
R1163	T1373	T1371	arg3Of	],[
R1164	T1374	T1375	arg1Of	Infection,with
R1165	T1374	T1378	arg1Of	Infection,triggers
R1166	T1377	T1375	arg2Of	aeruginosa,with
R1167	T1377	T1376	arg1Of	aeruginosa,P.
R1168	T1378	T1401	arg1Of	triggers,[
R1169	T1380	T1378	arg2Of	increase,triggers
R1170	T1380	T1379	arg1Of	increase,an
R1171	T1380	T1381	arg1Of	increase,in
R1172	T1380	T1390	arg1Of	increase,in
R1173	T1382	T1381	arg2Of	levels,in
R1174	T1382	T1383	arg1Of	levels,of
R1175	T1384	T1385	arg1Of	IL-1β,","
R1176	T1385	T1388	arg1Of	",",and
R1177	T1386	T1385	arg2Of	IL-6,","
R1178	T1388	T1383	arg2Of	and,of
R1179	T1388	T1387	arg1Of	and,","
R1180	T1389	T1388	arg2Of	IL-8,and
R1181	T1393	T1390	arg2Of	fluid,in
R1182	T1393	T1391	arg1Of	fluid,bronchoalveolar
R1183	T1393	T1392	arg1Of	fluid,lavage
R1184	T1393	T1394	arg1Of	fluid,(
R1185	T1393	T1397	arg1Of	fluid,from
R1186	T1395	T1394	arg2Of	BALF,(
R1187	T1396	T1394	arg3Of	),(
R1188	T1398	T1397	arg2Of	patients,from
R1189	T1398	T1399	arg1Of	patients,with
R1190	T1400	T1399	arg2Of	CF,with
R1191	T1402	T1401	arg2Of	21,[
R1192	T1403	T1401	arg3Of	],[
R1193	T1405	T1404	arg1Of	responses,Inflammasome
R1194	T1405	T1406	arg1Of	responses,depend
R1195	T1406	T1407	arg1Of	depend,on
R1196	T1406	T1436	arg1Of	depend,[
R1197	T1406	T1439	arg1Of	depend,","
R1198	T1406	T1440	arg1Of	depend,[
R1199	T1409	T1408	arg1Of	signaling,NF-κB
R1200	T1409	T1410	arg1Of	signaling,","
R1201	T1409	T1411	arg1Of	signaling,where
R1202	T1409	T1426	arg1Of	signaling,","
R1203	T1409	T1427	arg1Of	signaling,[
R1204	T1409	T1433	arg1Of	signaling,as
R1205	T1412	T1413	arg1Of	NF-κB,is
R1206	T1412	T1414	arg1Of	NF-κB,important
R1207	T1413	T1411	arg2Of	is,where
R1208	T1414	T1413	arg2Of	important,is
R1209	T1414	T1415	arg1Of	important,in
R1210	T1418	T1415	arg2Of	upregulation,in
R1211	T1418	T1416	arg1Of	upregulation,both
R1212	T1418	T1417	arg1Of	upregulation,the
R1213	T1418	T1419	arg1Of	upregulation,of
R1214	T1422	T1419	arg2Of	components,of
R1215	T1422	T1420	arg1Of	components,specific
R1216	T1422	T1421	arg1Of	components,inflammasome
R1217	T1422	T1423	arg1Of	components,[
R1218	T1424	T1423	arg2Of	22,[
R1219	T1425	T1423	arg3Of	],[
R1220	T1428	T1427	arg2Of	23,[
R1221	T1429	T1427	arg3Of	],[
R1222	T1433	T1407	arg2Of	as,on
R1223	T1433	T1430	arg1Of	as,","
R1224	T1433	T1431	arg1Of	as,as
R1225	T1433	T1432	arg1Of	as,well
R1226	T1435	T1433	arg2Of	expression,as
R1227	T1435	T1434	arg1Of	expression,IL-1β
R1228	T1437	T1436	arg2Of	24,[
R1229	T1438	T1436	arg3Of	],[
R1230	T1441	T1440	arg2Of	25,[
R1231	T1442	T1440	arg3Of	],[
R1232	T1444	T1443	arg1Of	studies,Previous
R1233	T1444	T1445	arg1Of	studies,support
R1234	T1447	T1445	arg2Of	role,support
R1235	T1447	T1446	arg1Of	role,a
R1236	T1447	T1448	arg1Of	role,for
R1237	T1447	T1450	arg1Of	role,in
R1238	T1449	T1448	arg2Of	IL-1β,for
R1239	T1452	T1450	arg2Of	pathogenesis,in
R1240	T1452	T1451	arg1Of	pathogenesis,the
R1241	T1452	T1453	arg1Of	pathogenesis,of
R1242	T1457	T1453	arg2Of	disease,of
R1243	T1457	T1454	arg1Of	disease,CF
R1244	T1457	T1455	arg1Of	disease,inflammatory
R1245	T1457	T1456	arg1Of	disease,lung
R1246	T1458	T1459	arg1Of	Levels,of
R1247	T1458	T1461	arg1Of	Levels,are
R1248	T1458	T1462	arg2Of	Levels,increased
R1249	T1460	T1459	arg2Of	IL-1β,of
R1250	T1462	T1461	arg2Of	increased,are
R1251	T1462	T1463	arg1Of	increased,in
R1252	T1462	T1473	arg1Of	increased,","
R1253	T1462	T1474	arg1Of	increased,[
R1254	T1462	T1477	arg1Of	increased,","
R1255	T1462	T1478	arg1Of	increased,[
R1256	T1462	T1481	arg1Of	increased,","
R1257	T1462	T1482	arg1Of	increased,[
R1258	T1462	T1485	arg1Of	increased,and
R1259	T1464	T1463	arg2Of	BALF,in
R1260	T1464	T1465	arg1Of	BALF,from
R1261	T1467	T1465	arg2Of	patients,from
R1262	T1467	T1466	arg1Of	patients,CF
R1263	T1467	T1468	arg1Of	patients,with
R1264	T1469	T1468	arg2Of	infection,with
R1265	T1469	T1470	arg1Of	infection,[
R1266	T1471	T1470	arg2Of	21,[
R1267	T1472	T1470	arg3Of	],[
R1268	T1475	T1474	arg2Of	26,[
R1269	T1476	T1474	arg3Of	],[
R1270	T1479	T1478	arg2Of	27,[
R1271	T1480	T1478	arg3Of	],[
R1272	T1483	T1482	arg2Of	28,[
R1273	T1484	T1482	arg3Of	],[
R1274	T1487	T1486	arg1Of	increase,this
R1275	T1487	T1488	arg1Of	increase,has
R1276	T1487	T1489	arg1Of	increase,been
R1277	T1487	T1491	arg2Of	increase,associated
R1278	T1491	T1485	arg2Of	associated,and
R1279	T1491	T1488	arg2Of	associated,has
R1280	T1491	T1489	arg2Of	associated,been
R1281	T1491	T1490	arg1Of	associated,temporally
R1282	T1491	T1492	arg1Of	associated,with
R1283	T1495	T1492	arg2Of	response,with
R1284	T1495	T1493	arg1Of	response,a
R1285	T1495	T1494	arg1Of	response,clinical
R1286	T1495	T1496	arg1Of	response,to
R1287	T1497	T1496	arg2Of	treatment,to
R1288	T1497	T1498	arg1Of	treatment,[
R1289	T1499	T1498	arg2Of	21,[
R1290	T1500	T1498	arg3Of	],[
R1291	T1501	T1502	arg1Of	Polymorphisms,in
R1292	T1501	T1506	arg1Of	Polymorphisms,have
R1293	T1501	T1508	arg1Of	Polymorphisms,been
R1294	T1501	T1509	arg2Of	Polymorphisms,associated
R1295	T1505	T1502	arg2Of	gene,in
R1296	T1505	T1503	arg1Of	gene,the
R1297	T1505	T1504	arg1Of	gene,IL1B
R1298	T1509	T1506	arg2Of	associated,have
R1299	T1509	T1507	arg1Of	associated,also
R1300	T1509	T1508	arg2Of	associated,been
R1301	T1509	T1510	arg1Of	associated,with
R1302	T1509	T1519	arg1Of	associated,[
R1303	T1512	T1510	arg2Of	degrees,with
R1304	T1512	T1511	arg1Of	degrees,varying
R1305	T1512	T1513	arg1Of	degrees,of
R1306	T1512	T1516	arg1Of	degrees,in
R1307	T1515	T1513	arg2Of	severity,of
R1308	T1515	T1514	arg1Of	severity,disease
R1309	T1518	T1516	arg2Of	patients,in
R1310	T1518	T1517	arg1Of	patients,CF
R1311	T1520	T1519	arg2Of	29,[
R1312	T1521	T1519	arg3Of	],[
R1313	T1523	T1522	arg1Of	models,Murine
R1314	T1523	T1524	arg1Of	models,of
R1315	T1523	T1527	arg1Of	models,have
R1316	T1523	T1528	arg1Of	models,exhibited
R1317	T1523	T1547	arg1Of	models,support
R1318	T1526	T1524	arg2Of	dysfunction,of
R1319	T1526	T1525	arg1Of	dysfunction,CFTR
R1320	T1528	T1527	arg2Of	exhibited,have
R1321	T1528	T1541	arg1Of	exhibited,","
R1322	T1528	T1542	arg1Of	exhibited,[
R1323	T1528	T1546	arg1Of	exhibited,and
R1324	T1530	T1528	arg2Of	increases,exhibited
R1325	T1530	T1529	arg1Of	increases,significant
R1326	T1530	T1531	arg1Of	increases,in
R1327	T1533	T1534	arg1Of	expression,or
R1328	T1534	T1531	arg2Of	or,in
R1329	T1534	T1532	arg1Of	or,IL-1β
R1330	T1534	T1536	arg1Of	or,in
R1331	T1535	T1534	arg2Of	secretion,or
R1332	T1537	T1536	arg2Of	macrophages,in
R1333	T1537	T1538	arg1Of	macrophages,[
R1334	T1539	T1538	arg2Of	30,[
R1335	T1540	T1538	arg3Of	],[
R1336	T1543	T1542	arg2Of	31,[
R1337	T1544	T1542	arg3Of	],[
R1338	T1546	T1545	arg1Of	and,","
R1339	T1547	T1546	arg2Of	support,and
R1340	T1547	T1574	arg1Of	support,","
R1341	T1547	T1575	arg1Of	support,[
R1342	T1549	T1547	arg2Of	hypothesis,support
R1343	T1549	T1548	arg1Of	hypothesis,the
R1344	T1552	T1551	arg1Of	loss,the
R1345	T1552	T1553	arg1Of	loss,of
R1346	T1552	T1555	arg1Of	loss,increases
R1347	T1554	T1553	arg2Of	CFTR,of
R1348	T1555	T1549	arg2Of	increases,hypothesis
R1349	T1555	T1550	arg1Of	increases,that
R1350	T1555	T1558	arg1Of	increases,under
R1351	T1555	T1566	arg1Of	increases,","
R1352	T1555	T1567	arg1Of	increases,[
R1353	T1555	T1570	arg1Of	increases,","
R1354	T1555	T1571	arg1Of	increases,[
R1355	T1557	T1555	arg2Of	activation,increases
R1356	T1557	T1556	arg1Of	activation,NF-κB
R1357	T1559	T1560	arg1Of	basal,and
R1358	T1561	T1560	arg2Of	stimulatory,and
R1359	T1562	T1558	arg2Of	conditions,under
R1360	T1562	T1559	arg1Of	conditions,basal
R1361	T1562	T1561	arg1Of	conditions,stimulatory
R1362	T1562	T1563	arg1Of	conditions,[
R1363	T1564	T1563	arg2Of	4,[
R1364	T1565	T1563	arg3Of	],[
R1365	T1568	T1567	arg2Of	5,[
R1366	T1569	T1567	arg3Of	],[
R1367	T1572	T1571	arg2Of	32,[
R1368	T1573	T1571	arg3Of	],[
R1369	T1576	T1575	arg2Of	33,[
R1370	T1577	T1575	arg3Of	],[
R1371	T1580	T1581	arg1Of	replacement,of
R1372	T1580	T1592	arg1Of	replacement,increases
R1373	T1583	T1581	arg2Of	ions,of
R1374	T1583	T1582	arg1Of	ions,chloride
R1375	T1583	T1584	arg1Of	ions,with
R1376	T1585	T1586	arg1Of	glutamate,or
R1377	T1586	T1584	arg2Of	or,with
R1378	T1586	T1588	arg1Of	or,in
R1379	T1587	T1586	arg2Of	gluconate,or
R1380	T1591	T1588	arg2Of	media,in
R1381	T1591	T1589	arg1Of	media,cell
R1382	T1591	T1590	arg1Of	media,culture
R1383	T1592	T1578	arg1Of	increases,Finally
R1384	T1592	T1579	arg1Of	increases,","
R1385	T1592	T1596	arg1Of	increases,in
R1386	T1592	T1610	arg1Of	increases,","
R1387	T1592	T1611	modOf	increases,implying
R1388	T1593	T1592	arg2Of	secretion,increases
R1389	T1593	T1594	arg1Of	secretion,of
R1390	T1595	T1594	arg2Of	IL-1β,of
R1391	T1597	T1596	arg2Of	response,in
R1392	T1597	T1598	arg1Of	response,to
R1393	T1600	T1598	arg2Of	stimulation,to
R1394	T1600	T1599	arg1Of	stimulation,NLRP3
R1395	T1600	T1601	arg1Of	stimulation,by
R1396	T1603	T1601	arg2Of	triphosphate,by
R1397	T1603	T1602	arg1Of	triphosphate,adenosine
R1398	T1603	T1604	arg1Of	triphosphate,(
R1399	T1603	T1607	arg1Of	triphosphate,[
R1400	T1605	T1604	arg2Of	ATP,(
R1401	T1606	T1604	arg3Of	),(
R1402	T1608	T1607	arg2Of	34,[
R1403	T1609	T1607	arg3Of	],[
R1404	T1614	T1611	arg2Of	role,implying
R1405	T1614	T1612	arg1Of	role,an
R1406	T1614	T1613	arg1Of	role,inhibitory
R1407	T1614	T1615	arg1Of	role,for
R1408	T1614	T1618	arg1Of	role,in
R1409	T1617	T1615	arg2Of	chloride,for
R1410	T1617	T1616	arg1Of	chloride,extracellular
R1411	T1620	T1618	arg2Of	activation,in
R1412	T1620	T1619	arg1Of	activation,NLRP3
R1413	T1621	T1622	arg1Of	Taken,together
R1414	T1625	T1624	arg1Of	data,these
R1415	T1625	T1626	arg1Of	data,implicate
R1416	T1626	T1621	modOf	implicate,Taken
R1417	T1626	T1623	arg1Of	implicate,","
R1418	T1626	T1636	arg1Of	implicate,","
R1419	T1626	T1637	arg1Of	implicate,in
R1420	T1628	T1626	arg2Of	involvement,implicate
R1421	T1628	T1627	arg1Of	involvement,the
R1422	T1628	T1629	arg1Of	involvement,of
R1423	T1628	T1632	arg1Of	involvement,consequently
R1424	T1628	T1633	arg1Of	involvement,","
R1425	T1629	T1631	arg1Of	of,and
R1426	T1630	T1629	arg2Of	IL-1β,of
R1427	T1632	T1631	arg2Of	consequently,and
R1428	T1635	T1633	arg2Of	inflammasomes,","
R1429	T1635	T1634	arg1Of	inflammasomes,the
R1430	T1640	T1637	arg2Of	disease,in
R1431	T1640	T1638	arg1Of	disease,CF
R1432	T1640	T1639	arg1Of	disease,inflammatory

sentences

Id	Subject	Object	Predicate	Lexical cue
T930	13-192	Sentence	denotes	Cystic fibrosis is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), which functions as a chloride ion channel.
T931	193-374	Sentence	denotes	CF remains one of the most common lethal genetic diseases in populations of European descent with the current average lifespan of CF patients approximately 40 years of age [1], [2].
T932	375-498	Sentence	denotes	Recurrent inflammatory pulmonary exacerbation is the primary cause of lung disease progression and ultimately, death in CF.
T933	499-658	Sentence	denotes	Controlled inflammation is important for fighting infection, but in excess, it becomes destructive to host cells and to the architecture of the lungs [2], [3].
T934	659-791	Sentence	denotes	In CF, airway epithelial cells have been shown to produce an exaggerated pro-inflammatory cytokine response to stimulation [4], [5].
T935	792-957	Sentence	denotes	It is unclear whether this heightened inflammatory response is intrinsic to cells lacking CFTR or whether it is a result of chronic polymicrobial infection [6], [7].
T936	958-1180	Sentence	denotes	Regardless of this controversy, identifying and targeting relevant inflammatory mediators is a critical step in developing more specific therapeutic approaches to control inflammation and improve health outcomes in CF [8].
T937	1181-1241	Sentence	denotes	Interleukin-1 beta (IL-1β) is a major inflammatory mediator.
T938	1242-1557	Sentence	denotes	Its physiological effects are diverse and potentially important to the pathogenesis of lung exacerbations in CF, including the generation of fever, the recruitment of inflammatory effector cells, the induction of other pro-inflammatory cytokines such as IL-6 and IL-8, and the shaping of T cell responses [9], [10].
T939	1558-1693	Sentence	denotes	Following initiation of the NF-κB signaling cascade, IL-1β is produced in the cytosol as a biologically inactive full-length pro-IL-1β.
T940	1694-2021	Sentence	denotes	Pro-IL-1β is subsequently converted into its active form by cytosolic protein complexes termed “inflammasomes.” Inflammasomes assemble in response to certain cellular danger signals and mediate the auto-activation of caspase-1 [9], [11], which cleaves pro-IL-1β and pro-IL-18 into their biologically active forms for secretion.
T941	2022-2071	Sentence	denotes	Four distinct inflammasomes have been recognized.
T942	2072-2254	Sentence	denotes	These are the NLRP1 [12], NLRP3 [13], [14], NLRC4 [15], [16], and AIM2 inflammasomes [17], [18], which respond to a variety of different microbial signatures and danger signals [11].
T943	2255-2390	Sentence	denotes	P. aeruginosa, one of the most common and clinically relevant pathogens among CF patients, activates the NLRC4 inflammasome [19], [20].
T944	2391-2542	Sentence	denotes	Infection with P. aeruginosa triggers an increase in levels of IL-1β, IL-6, and IL-8 in bronchoalveolar lavage fluid (BALF) from patients with CF [21].
T945	2543-2730	Sentence	denotes	Inflammasome responses depend on NF-κB signaling, where NF-κB is important in both the upregulation of specific inflammasome components [22], [23], as well as IL-1β expression [24], [25].
T946	2731-2825	Sentence	denotes	Previous studies support a role for IL-1β in the pathogenesis of CF inflammatory lung disease.
T947	2826-3011	Sentence	denotes	Levels of IL-1β are increased in BALF from CF patients with infection [21], [26], [27], [28] and this increase has been temporally associated with a clinical response to treatment [21].
T948	3012-3130	Sentence	denotes	Polymorphisms in the IL1B gene have also been associated with varying degrees of disease severity in CF patients [29].
T949	3131-3398	Sentence	denotes	Murine models of CFTR dysfunction have exhibited significant increases in IL-1β expression or secretion in macrophages [30], [31], and support the hypothesis that the loss of CFTR increases NF-κB activation under basal and stimulatory conditions [4], [5], [32], [33].
T950	3399-3662	Sentence	denotes	Finally, replacement of chloride ions with glutamate or gluconate in cell culture media increases secretion of IL-1β in response to NLRP3 stimulation by adenosine triphosphate (ATP) [34], implying an inhibitory role for extracellular chloride in NLRP3 activation.
T951	3663-3789	Sentence	denotes	Taken together, these data implicate the involvement of IL-1β and consequently, the inflammasomes, in CF inflammatory disease.
T19	0-12	Sentence	denotes	Introduction
T20	13-192	Sentence	denotes	Cystic fibrosis is an autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR), which functions as a chloride ion channel.
T21	193-374	Sentence	denotes	CF remains one of the most common lethal genetic diseases in populations of European descent with the current average lifespan of CF patients approximately 40 years of age [1], [2].
T22	375-498	Sentence	denotes	Recurrent inflammatory pulmonary exacerbation is the primary cause of lung disease progression and ultimately, death in CF.
T23	499-658	Sentence	denotes	Controlled inflammation is important for fighting infection, but in excess, it becomes destructive to host cells and to the architecture of the lungs [2], [3].
T24	659-791	Sentence	denotes	In CF, airway epithelial cells have been shown to produce an exaggerated pro-inflammatory cytokine response to stimulation [4], [5].
T25	792-957	Sentence	denotes	It is unclear whether this heightened inflammatory response is intrinsic to cells lacking CFTR or whether it is a result of chronic polymicrobial infection [6], [7].
T26	958-1180	Sentence	denotes	Regardless of this controversy, identifying and targeting relevant inflammatory mediators is a critical step in developing more specific therapeutic approaches to control inflammation and improve health outcomes in CF [8].
T27	1181-1241	Sentence	denotes	Interleukin-1 beta (IL-1β) is a major inflammatory mediator.
T28	1242-1557	Sentence	denotes	Its physiological effects are diverse and potentially important to the pathogenesis of lung exacerbations in CF, including the generation of fever, the recruitment of inflammatory effector cells, the induction of other pro-inflammatory cytokines such as IL-6 and IL-8, and the shaping of T cell responses [9], [10].
T29	1558-1693	Sentence	denotes	Following initiation of the NF-κB signaling cascade, IL-1β is produced in the cytosol as a biologically inactive full-length pro-IL-1β.
T30	1694-2021	Sentence	denotes	Pro-IL-1β is subsequently converted into its active form by cytosolic protein complexes termed “inflammasomes.” Inflammasomes assemble in response to certain cellular danger signals and mediate the auto-activation of caspase-1 [9], [11], which cleaves pro-IL-1β and pro-IL-18 into their biologically active forms for secretion.
T31	2022-2071	Sentence	denotes	Four distinct inflammasomes have been recognized.
T32	2072-2254	Sentence	denotes	These are the NLRP1 [12], NLRP3 [13], [14], NLRC4 [15], [16], and AIM2 inflammasomes [17], [18], which respond to a variety of different microbial signatures and danger signals [11].
T33	2255-2390	Sentence	denotes	P. aeruginosa, one of the most common and clinically relevant pathogens among CF patients, activates the NLRC4 inflammasome [19], [20].
T34	2391-2542	Sentence	denotes	Infection with P. aeruginosa triggers an increase in levels of IL-1β, IL-6, and IL-8 in bronchoalveolar lavage fluid (BALF) from patients with CF [21].
T35	2543-2730	Sentence	denotes	Inflammasome responses depend on NF-κB signaling, where NF-κB is important in both the upregulation of specific inflammasome components [22], [23], as well as IL-1β expression [24], [25].
T36	2731-2825	Sentence	denotes	Previous studies support a role for IL-1β in the pathogenesis of CF inflammatory lung disease.
T37	2826-3011	Sentence	denotes	Levels of IL-1β are increased in BALF from CF patients with infection [21], [26], [27], [28] and this increase has been temporally associated with a clinical response to treatment [21].
T38	3012-3130	Sentence	denotes	Polymorphisms in the IL1B gene have also been associated with varying degrees of disease severity in CF patients [29].
T39	3131-3398	Sentence	denotes	Murine models of CFTR dysfunction have exhibited significant increases in IL-1β expression or secretion in macrophages [30], [31], and support the hypothesis that the loss of CFTR increases NF-κB activation under basal and stimulatory conditions [4], [5], [32], [33].
T40	3399-3662	Sentence	denotes	Finally, replacement of chloride ions with glutamate or gluconate in cell culture media increases secretion of IL-1β in response to NLRP3 stimulation by adenosine triphosphate (ATP) [34], implying an inhibitory role for extracellular chloride in NLRP3 activation.
T41	3663-3789	Sentence	denotes	Taken together, these data implicate the involvement of IL-1β and consequently, the inflammasomes, in CF inflammatory disease.

2_test

Id	Subject	Object	Predicate	Lexical cue
22649552-18252915-88306670	371-372	18252915	denotes	2
22649552-18252915-88306671	650-651	18252915	denotes	2
22649552-11956063-88306672	655-656	11956063	denotes	3
22649552-10970832-88306673	783-784	10970832	denotes	4
22649552-11404248-88306674	788-789	11404248	denotes	5
22649552-16825601-88306675	949-950	16825601	denotes	6
22649552-7697269-88306676	954-955	7697269	denotes	7
22649552-15381503-88306677	1177-1178	15381503	denotes	8
22649552-20086235-88306678	1553-1555	20086235	denotes	10
22649552-21350580-88306679	1927-1929	21350580	denotes	11
22649552-12191486-88306680	2093-2095	12191486	denotes	12
22649552-15030775-88306681	2105-2107	15030775	denotes	13
22649552-16407890-88306682	2111-2113	16407890	denotes	14
22649552-15190255-88306683	2123-2125	15190255	denotes	15
22649552-16648853-88306684	2129-2131	16648853	denotes	16
22649552-19158676-88306685	2158-2160	19158676	denotes	17
22649552-19158675-88306686	2164-2166	19158675	denotes	18
22649552-21350580-88306687	2250-2252	21350580	denotes	11
22649552-18070936-88306688	2380-2382	18070936	denotes	19
22649552-19010992-88306689	2538-2540	19010992	denotes	21
22649552-19570822-88306690	2680-2682	19570822	denotes	22
22649552-16301671-88306691	2686-2688	16301671	denotes	23
22649552-8021507-88306692	2720-2722	8021507	denotes	24
22649552-8413223-88306693	2726-2728	8413223	denotes	25
22649552-19010992-88306694	2897-2899	19010992	denotes	21
22649552-8520783-88306695	2903-2905	8520783	denotes	26
22649552-10515411-88306696	2909-2911	10515411	denotes	27
22649552-16208679-88306697	2915-2917	16208679	denotes	28
22649552-19010992-88306698	3007-3009	19010992	denotes	21
22649552-19431193-88306699	3126-3128	19431193	denotes	29
22649552-21178113-88306700	3257-3259	21178113	denotes	31
22649552-10970832-88306701	3378-3379	10970832	denotes	4
22649552-11404248-88306702	3383-3384	11404248	denotes	5
22649552-20543983-88306703	3388-3390	20543983	denotes	32
22649552-18776130-88306704	3394-3396	18776130	denotes	33
22649552-16301672-88306705	3582-3584	16301672	denotes	34
T85898	371-372	18252915	denotes	2
T41701	650-651	18252915	denotes	2
T48945	655-656	11956063	denotes	3
T51403	783-784	10970832	denotes	4
T2050	788-789	11404248	denotes	5
T88634	949-950	16825601	denotes	6
T27899	954-955	7697269	denotes	7
T3751	1177-1178	15381503	denotes	8
T51662	1553-1555	20086235	denotes	10
T31735	1927-1929	21350580	denotes	11
T62254	2093-2095	12191486	denotes	12
T56249	2105-2107	15030775	denotes	13
T8344	2111-2113	16407890	denotes	14
T82915	2123-2125	15190255	denotes	15
T37753	2129-2131	16648853	denotes	16
T23506	2158-2160	19158676	denotes	17
T22148	2164-2166	19158675	denotes	18
T7622	2250-2252	21350580	denotes	11
T14488	2380-2382	18070936	denotes	19
T39745	2538-2540	19010992	denotes	21
T12002	2680-2682	19570822	denotes	22
T14767	2686-2688	16301671	denotes	23
T8246	2720-2722	8021507	denotes	24
T78036	2726-2728	8413223	denotes	25
T76824	2897-2899	19010992	denotes	21
T94729	2903-2905	8520783	denotes	26
T68481	2909-2911	10515411	denotes	27
T73546	2915-2917	16208679	denotes	28
T83481	3007-3009	19010992	denotes	21
T45701	3126-3128	19431193	denotes	29
T92061	3257-3259	21178113	denotes	31
T91667	3378-3379	10970832	denotes	4
T27983	3383-3384	11404248	denotes	5
T42884	3388-3390	20543983	denotes	32
T19477	3394-3396	18776130	denotes	33
T60798	3582-3584	16301672	denotes	34

PMC:3359311 / 1957-5746 JSONTXT

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PMC:3359311 / 1957-5746 JSON TXT