PMC:3359311 / 117-1955
Annnotations
bionlp-st-ge-2016-uniprot
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T364 | 171-189 | P01584 | denotes | Interleukin-1 beta |
| T365 | 191-196 | P01584 | denotes | IL-1β |
| T366 | 263-268 | P01584 | denotes | IL-1β |
| T367 | 354-359 | P01584 | denotes | IL-1β |
| T368 | 452-457 | P01584 | denotes | IL-1β |
| T369 | 640-645 | P01584 | denotes | IL-1β |
| T370 | 894-899 | P01584 | denotes | IL-1β |
| T371 | 1064-1069 | P01584 | denotes | IL-1β |
| T372 | 1132-1137 | P01584 | denotes | IL-1β |
| T373 | 1331-1336 | P01584 | denotes | IL-1β |
| T374 | 1340-1344 | P10145 | denotes | IL-8 |
| T375 | 1495-1500 | P01584 | denotes | IL-1β |
| T376 | 1585-1590 | P01584 | denotes | IL-1β |
| T377 | 1725-1730 | P01584 | denotes | IL-1β |
bionlp-st-ge-2016-reference
| Id | Subject | Object | Predicate | Lexical cue | Negation | Speculation |
|---|---|---|---|---|---|---|
| T49 | 590-597 | Gene_expression | denotes | produce | true | |
| T50 | 629-639 | Positive_regulation | denotes | stimulated | ||
| T40 | 171-189 | Protein | denotes | Interleukin-1 beta | ||
| T41 | 191-196 | Protein | denotes | IL-1β | ||
| T42 | 230-239 | Localization | denotes | Secretion | ||
| T43 | 263-268 | Protein | denotes | IL-1β | ||
| T44 | 269-277 | Regulation | denotes | involves | ||
| T45 | 354-359 | Protein | denotes | IL-1β | ||
| T46 | 443-451 | Positive_regulation | denotes | mediated | true | |
| T47 | 452-457 | Protein | denotes | IL-1β | ||
| T48 | 458-468 | Gene_expression | denotes | production | ||
| T51 | 640-645 | Protein | denotes | IL-1β | ||
| T52 | 868-876 | Gene_expression | denotes | produced | ||
| T53 | 894-899 | Protein | denotes | IL-1β | ||
| T54 | 944-948 | Positive_regulation | denotes | upon | ||
| T55 | 1064-1069 | Protein | denotes | IL-1β | ||
| T56 | 1070-1080 | Gene_expression | denotes | production | ||
| T57 | 1086-1096 | Positive_regulation | denotes | stimulated | ||
| T58 | 1132-1137 | Protein | denotes | IL-1β | ||
| T59 | 1325-1330 | Regulation | denotes | alter | true | |
| T60 | 1331-1336 | Protein | denotes | IL-1β | ||
| T61 | 1345-1355 | Gene_expression | denotes | production | ||
| T62 | 1356-1370 | Positive_regulation | denotes | in response to | ||
| T63 | 1470-1477 | Positive_regulation | denotes | induced | ||
| T64 | 1495-1500 | Protein | denotes | IL-1β | ||
| T65 | 1547-1556 | Positive_regulation | denotes | preserved | ||
| T66 | 1585-1590 | Protein | denotes | IL-1β | ||
| T67 | 1591-1600 | Localization | denotes | secretion | ||
| T68 | 1715-1724 | Positive_regulation | denotes | increased | ||
| T69 | 1724-1730 | Protein | denotes | IL-1β | ||
| T70 | 1731-1741 | Gene_expression | denotes | production | ||
| T71 | 1760-1763 | Positive_regulation | denotes | due | true | |
| R25 | T41 | T40 | equivalentTo | IL-1β,Interleukin-1 beta | ||
| R26 | T42 | T44 | themeOf | Secretion,involves | ||
| R27 | T43 | T42 | themeOf | IL-1β,Secretion | ||
| R28 | T47 | T48 | themeOf | IL-1β,production | ||
| R29 | T48 | T46 | themeOf | production,mediated | ||
| R30 | T49 | T50 | themeOf | produce,stimulated | ||
| R31 | T51 | T49 | themeOf | IL-1β,produce | ||
| R32 | T52 | T54 | themeOf | produced,upon | ||
| R33 | T53 | T52 | themeOf | IL-1β,produced | ||
| R34 | T55 | T56 | themeOf | IL-1β,production | ||
| R35 | T56 | T57 | themeOf | production,stimulated | ||
| R36 | T60 | T61 | themeOf | IL-1β,production | ||
| R37 | T61 | T62 | themeOf | production,in response to | ||
| R38 | T62 | T59 | themeOf | in response to,alter | ||
| R39 | T64 | T63 | themeOf | IL-1β,induced | ||
| R40 | T66 | T67 | themeOf | IL-1β,secretion | ||
| R41 | T67 | T65 | themeOf | secretion,preserved | ||
| R42 | T68 | T71 | themeOf | increased,due | ||
| R43 | T69 | T70 | themeOf | IL-1β,production | ||
| R44 | T70 | T68 | themeOf | production,increased |
bionlp-st-ge-2016-reference-tees
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T802 | 171-189 | Protein | denotes | Interleukin-1 beta |
| T803 | 191-196 | Protein | denotes | IL-1β |
| T804 | 220-228 | Positive_regulation | denotes | mediator |
| T805 | 220-228 | Positive_regulation | denotes | mediator |
| T806 | 263-268 | Protein | denotes | IL-1β |
| T807 | 230-239 | Localization | denotes | Secretion |
| T808 | 354-359 | Protein | denotes | IL-1β |
| T809 | 640-645 | Protein | denotes | IL-1β |
| T810 | 720-729 | Protein | denotes | caspase-1 |
| T811 | 590-597 | Gene_expression | denotes | produce |
| T812 | 709-719 | Positive_regulation | denotes | upregulate |
| T813 | 894-899 | Protein | denotes | IL-1β |
| T814 | 925-934 | Protein | denotes | caspase-1 |
| T815 | 868-876 | Gene_expression | denotes | produced |
| T816 | 913-924 | Positive_regulation | denotes | upregulated |
| T817 | 883-890 | Positive_regulation | denotes | amounts |
| T818 | 1039-1048 | Protein | denotes | caspase-1 |
| T819 | 1064-1069 | Protein | denotes | IL-1β |
| T820 | 1049-1059 | Positive_regulation | denotes | activation |
| T821 | 1070-1080 | Gene_expression | denotes | production |
| T822 | 1049-1059 | Positive_regulation | denotes | activation |
| T823 | 1132-1137 | Protein | denotes | IL-1β |
| T824 | 1166-1171 | Protein | denotes | NF-κB |
| T825 | 1138-1148 | Gene_expression | denotes | production |
| T826 | 1153-1162 | Positive_regulation | denotes | dependent |
| T827 | 1194-1202 | Positive_regulation | denotes | enhanced |
| T828 | 1256-1260 | Protein | denotes | CFTR |
| T829 | 1331-1336 | Protein | denotes | IL-1β |
| T830 | 1340-1344 | Protein | denotes | IL-8 |
| T831 | 1242-1252 | Negative_regulation | denotes | inhibition |
| T832 | 1345-1355 | Gene_expression | denotes | production |
| T833 | 1345-1355 | Gene_expression | denotes | production |
| T834 | 1325-1330 | Positive_regulation | denotes | alter |
| T835 | 1325-1330 | Positive_regulation | denotes | alter |
| T836 | 1495-1500 | Protein | denotes | IL-1β |
| T837 | 1585-1590 | Protein | denotes | IL-1β |
| T838 | 1626-1660 | Protein | denotes | CF pathogen Pseudomonas aeruginosa |
| T839 | 1591-1600 | Localization | denotes | secretion |
| T840 | 1591-1600 | Localization | denotes | secretion |
| T841 | 1725-1730 | Protein | denotes | IL-1β |
| T842 | 1792-1797 | Protein | denotes | NF-κB |
| T843 | 1823-1827 | Protein | denotes | CFTR |
| T844 | 1731-1741 | Gene_expression | denotes | production |
| T845 | 1760-1763 | Positive_regulation | denotes | due |
| T846 | 1780-1788 | Positive_regulation | denotes | increase |
| T847 | 1815-1819 | Negative_regulation | denotes | loss |
| T848 | 1715-1724 | Positive_regulation | denotes | increased |
| R667 | T802 | T804 | themeOf | Interleukin-1 beta,mediator |
| R668 | T803 | T805 | themeOf | IL-1β,mediator |
| R669 | T806 | T807 | themeOf | IL-1β,Secretion |
| R670 | T809 | T811 | themeOf | IL-1β,produce |
| R671 | T810 | T812 | themeOf | caspase-1,upregulate |
| R672 | T813 | T815 | themeOf | IL-1β,produced |
| R673 | T814 | T816 | themeOf | caspase-1,upregulated |
| R674 | T816 | T817 | themeOf | upregulated,amounts |
| R675 | T818 | T820 | themeOf | caspase-1,activation |
| R676 | T819 | T821 | themeOf | IL-1β,production |
| R677 | T821 | T822 | themeOf | production,activation |
| R678 | T823 | T825 | themeOf | IL-1β,production |
| R679 | T825 | T826 | themeOf | production,dependent |
| R680 | T825 | T827 | themeOf | production,enhanced |
| R681 | T828 | T831 | themeOf | CFTR,inhibition |
| R682 | T829 | T832 | themeOf | IL-1β,production |
| R683 | T830 | T833 | themeOf | IL-8,production |
| R684 | T832 | T834 | themeOf | production,alter |
| R685 | T833 | T835 | themeOf | production,alter |
| R686 | T837 | T839 | themeOf | IL-1β,secretion |
| R687 | T838 | T840 | themeOf | CF pathogen Pseudomonas aeruginosa,secretion |
| R688 | T841 | T844 | themeOf | IL-1β,production |
| R689 | T842 | T846 | themeOf | NF-κB,increase |
| R690 | T843 | T847 | themeOf | CFTR,loss |
| R691 | T844 | T845 | themeOf | production,due |
| R692 | T844 | T848 | themeOf | production,increased |
events-check-again
| Id | Subject | Object | Predicate | Lexical cue | Negation | Speculation |
|---|---|---|---|---|---|---|
| T770 | 171-189 | Protein | denotes | Interleukin-1 beta | ||
| T771 | 191-196 | Protein | denotes | IL-1β | ||
| T772 | 230-239 | Localization | denotes | Secretion | ||
| T773 | 263-268 | Protein | denotes | IL-1β | ||
| T774 | 269-277 | Regulation | denotes | involves | ||
| T775 | 354-359 | Protein | denotes | IL-1β | ||
| T776 | 443-451 | Positive_regulation | denotes | mediated | true | |
| T777 | 452-457 | Protein | denotes | IL-1β | ||
| T778 | 458-468 | Gene_expression | denotes | production | ||
| T779 | 590-597 | Gene_expression | denotes | produce | true | |
| T780 | 629-639 | Positive_regulation | denotes | stimulated | ||
| T781 | 640-645 | Protein | denotes | IL-1β | ||
| T782 | 868-876 | Gene_expression | denotes | produced | ||
| T783 | 894-899 | Protein | denotes | IL-1β | ||
| T784 | 944-948 | Positive_regulation | denotes | upon | ||
| T785 | 1064-1069 | Protein | denotes | IL-1β | ||
| T786 | 1070-1080 | Gene_expression | denotes | production | ||
| T787 | 1086-1096 | Positive_regulation | denotes | stimulated | ||
| T788 | 1132-1137 | Protein | denotes | IL-1β | ||
| T789 | 1325-1330 | Regulation | denotes | alter | true | |
| T790 | 1331-1336 | Protein | denotes | IL-1β | ||
| T791 | 1345-1355 | Gene_expression | denotes | production | ||
| T792 | 1356-1370 | Positive_regulation | denotes | in response to | ||
| T793 | 1470-1477 | Positive_regulation | denotes | induced | ||
| T794 | 1495-1500 | Protein | denotes | IL-1β | ||
| T795 | 1547-1556 | Positive_regulation | denotes | preserved | ||
| T796 | 1585-1590 | Protein | denotes | IL-1β | ||
| T797 | 1591-1600 | Localization | denotes | secretion | ||
| T798 | 1715-1724 | Positive_regulation | denotes | increased | ||
| T799 | 1724-1730 | Protein | denotes | IL-1β | ||
| T800 | 1731-1741 | Gene_expression | denotes | production | ||
| T801 | 1760-1763 | Positive_regulation | denotes | due | true | |
| R647 | T771 | T770 | equivalentTo | IL-1β,Interleukin-1 beta | ||
| R648 | T772 | T774 | themeOf | Secretion,involves | ||
| R649 | T773 | T772 | themeOf | IL-1β,Secretion | ||
| R650 | T777 | T778 | themeOf | IL-1β,production | ||
| R651 | T778 | T776 | themeOf | production,mediated | ||
| R652 | T779 | T780 | themeOf | produce,stimulated | ||
| R653 | T781 | T779 | themeOf | IL-1β,produce | ||
| R654 | T782 | T784 | themeOf | produced,upon | ||
| R655 | T783 | T782 | themeOf | IL-1β,produced | ||
| R656 | T785 | T786 | themeOf | IL-1β,production | ||
| R657 | T786 | T787 | themeOf | production,stimulated | ||
| R658 | T790 | T791 | themeOf | IL-1β,production | ||
| R659 | T791 | T792 | themeOf | production,in response to | ||
| R660 | T792 | T789 | themeOf | in response to,alter | ||
| R661 | T794 | T793 | themeOf | IL-1β,induced | ||
| R662 | T796 | T797 | themeOf | IL-1β,secretion | ||
| R663 | T797 | T795 | themeOf | secretion,preserved | ||
| R664 | T798 | T801 | themeOf | increased,due | ||
| R665 | T799 | T800 | themeOf | IL-1β,production | ||
| R666 | T800 | T798 | themeOf | production,increased |
ICD10
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T694 | 149-164 | http://purl.bioontology.org/ontology/ICD10/E84 | denotes | cystic fibrosis |
| T695 | 149-164 | http://purl.bioontology.org/ontology/ICD10/E84.9 | denotes | cystic fibrosis |
GO-CC
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T688 | 496-500 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T689 | 565-569 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cell |
| T690 | 672-677 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T691 | 812-817 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T692 | 1297-1302 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
| T693 | 1412-1417 | http://purl.obolibrary.org/obo/GO_0005623 | denotes | cells |
GO-MF
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T696 | 1340-1344 | http://purl.obolibrary.org/obo/GO_0005153 | denotes | IL-8 |
GO-BP
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T680 | 11-23 | http://purl.obolibrary.org/obo/GO_0006954 | denotes | Inflammation |
| T681 | 171-189 | http://purl.obolibrary.org/obo/GO_0050720 | denotes | Interleukin-1 beta |
| T682 | 171-189 | http://purl.obolibrary.org/obo/GO_0050702 | denotes | Interleukin-1 beta |
| T683 | 183-193 | http://purl.obolibrary.org/obo/GO_0032611 | denotes | 1 beta (IL |
| T684 | 230-239 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | Secretion |
| T685 | 1591-1600 | http://purl.obolibrary.org/obo/GO_0046903 | denotes | secretion |
| T686 | 1340-1355 | http://purl.obolibrary.org/obo/GO_0032677 | denotes | IL-8 production |
| T687 | 1340-1355 | http://purl.obolibrary.org/obo/GO_0032637 | denotes | IL-8 production |
UBERON-AE
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T36 | 794-799 | http://purl.obolibrary.org/obo/UBERON_0000178 | denotes | blood |
bionlp-st-ge-2016-spacy-parsed
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T386 | 0-10 | NNP | denotes | Background |
| T387 | 11-23 | NNP | denotes | Inflammation |
| T388 | 24-27 | CC | denotes | and |
| T389 | 28-37 | NN | denotes | infection |
| T390 | 38-41 | VBP | denotes | are |
| T391 | 42-47 | JJ | denotes | major |
| T392 | 48-60 | NNS | denotes | determinants |
| T393 | 61-63 | IN | denotes | of |
| T394 | 64-71 | NN | denotes | disease |
| T395 | 72-80 | NN | denotes | severity |
| T396 | 81-84 | CC | denotes | and |
| T397 | 85-97 | RB | denotes | consequently |
| T398 | 97-98 | , | denotes | , |
| T399 | 99-102 | DT | denotes | the |
| T400 | 103-110 | NN | denotes | quality |
| T401 | 111-113 | IN | denotes | of |
| T402 | 114-118 | NN | denotes | life |
| T403 | 119-122 | CC | denotes | and |
| T404 | 123-130 | NN | denotes | outcome |
| T405 | 131-134 | IN | denotes | for |
| T406 | 135-143 | NNS | denotes | patients |
| T407 | 144-148 | IN | denotes | with |
| T408 | 149-155 | JJ | denotes | cystic |
| T409 | 156-164 | NN | denotes | fibrosis |
| T410 | 165-166 | -LRB- | denotes | ( |
| T411 | 166-168 | NNP | denotes | CF |
| T412 | 168-169 | -RRB- | denotes | ) |
| T413 | 169-170 | . | denotes | . |
| T414 | 171-184 | NN | denotes | Interleukin-1 |
| T415 | 185-189 | NN | denotes | beta |
| T416 | 190-191 | -LRB- | denotes | ( |
| T417 | 191-196 | NN | denotes | IL-1β |
| T418 | 196-197 | -RRB- | denotes | ) |
| T419 | 198-200 | VBZ | denotes | is |
| T420 | 201-202 | DT | denotes | a |
| T421 | 203-206 | JJ | denotes | key |
| T422 | 207-219 | JJ | denotes | inflammatory |
| T423 | 220-228 | NN | denotes | mediator |
| T424 | 228-229 | . | denotes | . |
| T425 | 230-239 | NNP | denotes | Secretion |
| T426 | 240-242 | IN | denotes | of |
| T427 | 243-255 | RB | denotes | biologically |
| T428 | 256-262 | JJ | denotes | active |
| T429 | 263-268 | JJ | denotes | IL-1β |
| T430 | 269-277 | VBZ | denotes | involves |
| T431 | 278-299 | JJ | denotes | inflammasome-mediated |
| T432 | 300-310 | NN | denotes | processing |
| T433 | 310-311 | . | denotes | . |
| T434 | 312-318 | NNP | denotes | Little |
| T435 | 319-321 | VBZ | denotes | is |
| T436 | 322-327 | VBN | denotes | known |
| T437 | 328-333 | IN | denotes | about |
| T438 | 334-337 | DT | denotes | the |
| T439 | 338-350 | NN | denotes | contribution |
| T440 | 351-353 | IN | denotes | of |
| T441 | 354-359 | NN | denotes | IL-1β |
| T442 | 360-363 | CC | denotes | and |
| T443 | 364-367 | DT | denotes | the |
| T444 | 368-381 | NNS | denotes | inflammasomes |
| T445 | 382-384 | IN | denotes | in |
| T446 | 385-387 | NNP | denotes | CF |
| T447 | 388-400 | JJ | denotes | inflammatory |
| T448 | 401-408 | NN | denotes | disease |
| T449 | 408-409 | . | denotes | . |
| T450 | 410-414 | DT | denotes | This |
| T451 | 415-420 | NN | denotes | study |
| T452 | 421-429 | VBZ | denotes | examines |
| T453 | 430-451 | JJ | denotes | inflammasome-mediated |
| T454 | 452-457 | JJ | denotes | IL-1β |
| T455 | 458-468 | NN | denotes | production |
| T456 | 469-471 | IN | denotes | in |
| T457 | 472-474 | NNP | denotes | CF |
| T458 | 475-484 | JJ | denotes | bronchial |
| T459 | 485-495 | JJ | denotes | epithelial |
| T460 | 496-500 | NN | denotes | cell |
| T461 | 501-506 | NNS | denotes | lines |
| T462 | 507-510 | CC | denotes | and |
| T463 | 511-516 | JJ | denotes | human |
| T464 | 517-525 | NNS | denotes | patients |
| T465 | 526-530 | IN | denotes | with |
| T466 | 531-534 | NNP | denotes | CF. |
| T467 | 536-543 | NNS | denotes | Results |
| T468 | 544-553 | NNP | denotes | Bronchial |
| T469 | 554-564 | JJ | denotes | epithelial |
| T470 | 565-569 | NN | denotes | cell |
| T471 | 570-575 | NNS | denotes | lines |
| T472 | 576-580 | VBD | denotes | were |
| T473 | 581-586 | VBN | denotes | found |
| T474 | 587-589 | TO | denotes | to |
| T475 | 590-597 | VB | denotes | produce |
| T476 | 598-608 | JJ | denotes | negligible |
| T477 | 609-616 | NNS | denotes | amounts |
| T478 | 617-619 | IN | denotes | of |
| T479 | 620-625 | NN | denotes | basal |
| T480 | 626-628 | CC | denotes | or |
| T481 | 629-639 | VBN | denotes | stimulated |
| T482 | 640-645 | NN | denotes | IL-1β |
| T483 | 646-654 | VBN | denotes | compared |
| T484 | 655-657 | TO | denotes | to |
| T485 | 658-671 | JJ | denotes | hematopoeitic |
| T486 | 672-677 | NNS | denotes | cells |
| T487 | 678-681 | CC | denotes | and |
| T488 | 682-686 | PRP | denotes | they |
| T489 | 687-690 | VBD | denotes | did |
| T490 | 691-694 | RB | denotes | not |
| T491 | 695-708 | RB | denotes | significantly |
| T492 | 709-719 | VB | denotes | upregulate |
| T493 | 720-729 | JJ | denotes | caspase-1 |
| T494 | 730-738 | NN | denotes | activity |
| T495 | 739-743 | IN | denotes | upon |
| T496 | 744-756 | JJ | denotes | inflammasome |
| T497 | 757-768 | NN | denotes | stimulation |
| T498 | 768-769 | . | denotes | . |
| T499 | 770-772 | IN | denotes | In |
| T500 | 773-781 | NN | denotes | contrast |
| T501 | 781-782 | , | denotes | , |
| T502 | 783-793 | JJ | denotes | peripheral |
| T503 | 794-799 | NN | denotes | blood |
| T504 | 800-811 | NN | denotes | mononuclear |
| T505 | 812-817 | NNS | denotes | cells |
| T506 | 818-819 | -LRB- | denotes | ( |
| T507 | 819-824 | NNS | denotes | PBMCs |
| T508 | 824-825 | -RRB- | denotes | ) |
| T509 | 826-830 | IN | denotes | from |
| T510 | 831-835 | DT | denotes | both |
| T511 | 836-838 | NNP | denotes | CF |
| T512 | 839-842 | CC | denotes | and |
| T513 | 843-850 | JJ | denotes | healthy |
| T514 | 851-858 | NN | denotes | control |
| T515 | 859-867 | NNS | denotes | subjects |
| T516 | 868-876 | VBD | denotes | produced |
| T517 | 877-882 | JJ | denotes | large |
| T518 | 883-890 | NNS | denotes | amounts |
| T519 | 891-893 | IN | denotes | of |
| T520 | 894-899 | NN | denotes | IL-1β |
| T521 | 900-903 | CC | denotes | and |
| T522 | 904-912 | RB | denotes | strongly |
| T523 | 913-924 | VBD | denotes | upregulated |
| T524 | 925-934 | JJ | denotes | caspase-1 |
| T525 | 935-943 | NN | denotes | activity |
| T526 | 944-948 | IN | denotes | upon |
| T527 | 949-961 | JJ | denotes | inflammasome |
| T528 | 962-973 | NN | denotes | stimulation |
| T529 | 973-974 | . | denotes | . |
| T530 | 975-980 | NNS | denotes | PBMCs |
| T531 | 981-985 | IN | denotes | from |
| T532 | 986-988 | NNP | denotes | CF |
| T533 | 989-997 | NNS | denotes | patients |
| T534 | 998-1001 | CC | denotes | and |
| T535 | 1002-1010 | NNS | denotes | controls |
| T536 | 1011-1020 | VBD | denotes | displayed |
| T537 | 1021-1028 | JJ | denotes | similar |
| T538 | 1029-1035 | NNS | denotes | levels |
| T539 | 1036-1038 | IN | denotes | of |
| T540 | 1039-1048 | JJ | denotes | caspase-1 |
| T541 | 1049-1059 | NN | denotes | activation |
| T542 | 1060-1063 | CC | denotes | and |
| T543 | 1064-1069 | JJ | denotes | IL-1β |
| T544 | 1070-1080 | NN | denotes | production |
| T545 | 1081-1085 | WRB | denotes | when |
| T546 | 1086-1096 | VBN | denotes | stimulated |
| T547 | 1097-1101 | IN | denotes | with |
| T548 | 1102-1114 | JJ | denotes | inflammasome |
| T549 | 1115-1125 | NNS | denotes | activators |
| T550 | 1125-1126 | . | denotes | . |
| T551 | 1127-1131 | DT | denotes | This |
| T552 | 1132-1137 | JJ | denotes | IL-1β |
| T553 | 1138-1148 | NN | denotes | production |
| T554 | 1149-1152 | VBD | denotes | was |
| T555 | 1153-1162 | JJ | denotes | dependent |
| T556 | 1163-1165 | IN | denotes | on |
| T557 | 1166-1171 | JJ | denotes | NF-κB |
| T558 | 1172-1180 | NN | denotes | activity |
| T559 | 1181-1184 | CC | denotes | and |
| T560 | 1185-1190 | MD | denotes | could |
| T561 | 1191-1193 | VB | denotes | be |
| T562 | 1194-1202 | VBN | denotes | enhanced |
| T563 | 1203-1205 | IN | denotes | by |
| T564 | 1206-1213 | VBG | denotes | priming |
| T565 | 1214-1218 | IN | denotes | with |
| T566 | 1219-1222 | NNP | denotes | LPS |
| T567 | 1222-1223 | . | denotes | . |
| T568 | 1224-1231 | RB | denotes | Finally |
| T569 | 1231-1232 | , | denotes | , |
| T570 | 1233-1241 | NN | denotes | chemical |
| T571 | 1242-1252 | NN | denotes | inhibition |
| T572 | 1253-1255 | IN | denotes | of |
| T573 | 1256-1260 | NNP | denotes | CFTR |
| T574 | 1261-1269 | NN | denotes | activity |
| T575 | 1270-1272 | IN | denotes | in |
| T576 | 1273-1280 | NN | denotes | control |
| T577 | 1281-1286 | NNS | denotes | PBMCs |
| T578 | 1287-1290 | CC | denotes | and |
| T579 | 1291-1296 | CD | denotes | THP-1 |
| T580 | 1297-1302 | NNS | denotes | cells |
| T581 | 1303-1306 | VBD | denotes | did |
| T582 | 1307-1310 | RB | denotes | not |
| T583 | 1311-1324 | RB | denotes | significantly |
| T584 | 1325-1330 | VB | denotes | alter |
| T585 | 1331-1336 | JJ | denotes | IL-1β |
| T586 | 1337-1339 | CC | denotes | or |
| T587 | 1340-1344 | JJ | denotes | IL-8 |
| T588 | 1345-1355 | NN | denotes | production |
| T589 | 1356-1358 | IN | denotes | in |
| T590 | 1359-1367 | NN | denotes | response |
| T591 | 1368-1370 | TO | denotes | to |
| T592 | 1371-1373 | NNP | denotes | P. |
| T593 | 1374-1384 | NN | denotes | aeruginosa |
| T594 | 1384-1385 | . | denotes | . |
| T595 | 1387-1397 | NNP | denotes | Conclusion |
| T596 | 1398-1411 | NNP | denotes | Hematopoeitic |
| T597 | 1412-1417 | NNS | denotes | cells |
| T598 | 1418-1424 | VBP | denotes | appear |
| T599 | 1425-1427 | TO | denotes | to |
| T600 | 1428-1430 | VB | denotes | be |
| T601 | 1431-1434 | DT | denotes | the |
| T602 | 1435-1446 | JJ | denotes | predominant |
| T603 | 1447-1453 | NN | denotes | source |
| T604 | 1454-1456 | IN | denotes | of |
| T605 | 1457-1477 | JJ | denotes | inflammasome-induced |
| T606 | 1478-1494 | JJ | denotes | pro-inflammatory |
| T607 | 1495-1500 | NN | denotes | IL-1β |
| T608 | 1501-1503 | IN | denotes | in |
| T609 | 1504-1507 | NNP | denotes | CF. |
| T610 | 1508-1513 | NNP | denotes | PBMCs |
| T611 | 1514-1521 | VBD | denotes | derived |
| T612 | 1522-1526 | IN | denotes | from |
| T613 | 1527-1529 | NNP | denotes | CF |
| T614 | 1530-1538 | NNS | denotes | subjects |
| T615 | 1539-1546 | VBP | denotes | display |
| T616 | 1547-1556 | VBN | denotes | preserved |
| T617 | 1557-1569 | JJ | denotes | inflammasome |
| T618 | 1570-1580 | NN | denotes | activation |
| T619 | 1581-1584 | CC | denotes | and |
| T620 | 1585-1590 | JJ | denotes | IL-1β |
| T621 | 1591-1600 | NN | denotes | secretion |
| T622 | 1601-1603 | IN | denotes | in |
| T623 | 1604-1612 | NN | denotes | response |
| T624 | 1613-1615 | TO | denotes | to |
| T625 | 1616-1619 | DT | denotes | the |
| T626 | 1620-1625 | JJ | denotes | major |
| T627 | 1626-1628 | NNP | denotes | CF |
| T628 | 1629-1637 | NN | denotes | pathogen |
| T629 | 1638-1649 | NNP | denotes | Pseudomonas |
| T630 | 1650-1660 | NN | denotes | aeruginosa |
| T631 | 1660-1661 | . | denotes | . |
| T632 | 1662-1669 | RB | denotes | However |
| T633 | 1669-1670 | , | denotes | , |
| T634 | 1671-1674 | PRP$ | denotes | our |
| T635 | 1675-1679 | NNS | denotes | data |
| T636 | 1680-1682 | VBP | denotes | do |
| T637 | 1683-1686 | RB | denotes | not |
| T638 | 1687-1694 | VB | denotes | support |
| T639 | 1695-1698 | DT | denotes | the |
| T640 | 1699-1709 | NN | denotes | hypothesis |
| T641 | 1710-1714 | WDT | denotes | that |
| T642 | 1715-1724 | VBD | denotes | increased |
| T643 | 1725-1730 | JJ | denotes | IL-1β |
| T644 | 1731-1741 | NN | denotes | production |
| T645 | 1742-1744 | IN | denotes | in |
| T646 | 1745-1747 | NNP | denotes | CF |
| T647 | 1748-1756 | NNS | denotes | subjects |
| T648 | 1757-1759 | VBZ | denotes | is |
| T649 | 1760-1763 | JJ | denotes | due |
| T650 | 1764-1766 | TO | denotes | to |
| T651 | 1767-1769 | DT | denotes | an |
| T652 | 1770-1779 | JJ | denotes | intrinsic |
| T653 | 1780-1788 | NN | denotes | increase |
| T654 | 1789-1791 | IN | denotes | in |
| T655 | 1792-1797 | JJ | denotes | NF-κB |
| T656 | 1798-1806 | NN | denotes | activity |
| T657 | 1807-1814 | IN | denotes | through |
| T658 | 1815-1819 | NN | denotes | loss |
| T659 | 1820-1822 | IN | denotes | of |
| T660 | 1823-1827 | NNP | denotes | CFTR |
| T661 | 1828-1836 | NN | denotes | function |
| T662 | 1836-1837 | . | denotes | . |
| R324 | T386 | T387 | compound | Background,Inflammation |
| R326 | T388 | T387 | cc | and,Inflammation |
| R327 | T389 | T387 | conj | infection,Inflammation |
| R328 | T390 | T390 | ROOT | are,are |
| R329 | T391 | T392 | amod | major,determinants |
| R330 | T392 | T390 | attr | determinants,are |
| R331 | T393 | T392 | prep | of,determinants |
| R332 | T394 | T395 | compound | disease,severity |
| R333 | T395 | T393 | pobj | severity,of |
| R334 | T396 | T390 | cc | and,are |
| R335 | T397 | T400 | advmod | consequently,quality |
| R336 | T398 | T400 | punct | ",",quality |
| R337 | T399 | T400 | det | the,quality |
| R338 | T400 | T390 | conj | quality,are |
| R339 | T401 | T400 | prep | of,quality |
| R340 | T402 | T401 | pobj | life,of |
| R341 | T403 | T402 | cc | and,life |
| R342 | T404 | T400 | conj | outcome,quality |
| R343 | T405 | T400 | prep | for,quality |
| R344 | T406 | T405 | pobj | patients,for |
| R345 | T407 | T406 | prep | with,patients |
| R346 | T408 | T409 | compound | cystic,fibrosis |
| R347 | T409 | T407 | pobj | fibrosis,with |
| R348 | T410 | T411 | punct | (,CF |
| R349 | T411 | T409 | appos | CF,fibrosis |
| R350 | T412 | T400 | punct | ),quality |
| R351 | T413 | T390 | punct | .,are |
| R352 | T414 | T415 | compound | Interleukin-1,beta |
| R353 | T415 | T419 | nsubj | beta,is |
| R354 | T416 | T417 | punct | (,IL-1β |
| R355 | T417 | T415 | appos | IL-1β,beta |
| R356 | T418 | T417 | punct | ),IL-1β |
| R357 | T419 | T419 | ROOT | is,is |
| R358 | T420 | T423 | det | a,mediator |
| R359 | T421 | T423 | amod | key,mediator |
| R360 | T422 | T423 | amod | inflammatory,mediator |
| R361 | T423 | T419 | attr | mediator,is |
| R362 | T424 | T419 | punct | .,is |
| R363 | T425 | T430 | nsubj | Secretion,involves |
| R364 | T426 | T425 | prep | of,Secretion |
| R365 | T427 | T428 | advmod | biologically,active |
| R366 | T428 | T429 | amod | active,IL-1β |
| R367 | T429 | T426 | pobj | IL-1β,of |
| R368 | T430 | T430 | ROOT | involves,involves |
| R369 | T431 | T432 | amod | inflammasome-mediated,processing |
| R370 | T432 | T430 | dobj | processing,involves |
| R371 | T433 | T430 | punct | .,involves |
| R372 | T434 | T436 | nsubjpass | Little,known |
| R373 | T435 | T436 | auxpass | is,known |
| R374 | T436 | T436 | ROOT | known,known |
| R375 | T437 | T436 | prep | about,known |
| R376 | T438 | T439 | det | the,contribution |
| R377 | T439 | T437 | pobj | contribution,about |
| R378 | T440 | T439 | prep | of,contribution |
| R379 | T441 | T440 | pobj | IL-1β,of |
| R380 | T442 | T441 | cc | and,IL-1β |
| R381 | T443 | T444 | det | the,inflammasomes |
| R382 | T444 | T441 | conj | inflammasomes,IL-1β |
| R383 | T445 | T444 | prep | in,inflammasomes |
| R384 | T446 | T448 | nmod | CF,disease |
| R385 | T447 | T448 | amod | inflammatory,disease |
| R386 | T448 | T445 | pobj | disease,in |
| R387 | T449 | T436 | punct | .,known |
| R388 | T450 | T451 | det | This,study |
| R389 | T451 | T452 | nsubj | study,examines |
| R390 | T452 | T452 | ROOT | examines,examines |
| R391 | T453 | T455 | amod | inflammasome-mediated,production |
| R392 | T454 | T455 | compound | IL-1β,production |
| R393 | T455 | T452 | dobj | production,examines |
| R394 | T456 | T455 | prep | in,production |
| R395 | T457 | T461 | nmod | CF,lines |
| R396 | T458 | T461 | amod | bronchial,lines |
| R397 | T459 | T461 | amod | epithelial,lines |
| R398 | T460 | T461 | compound | cell,lines |
| R399 | T461 | T456 | pobj | lines,in |
| R400 | T462 | T461 | cc | and,lines |
| R401 | T463 | T464 | amod | human,patients |
| R402 | T464 | T461 | conj | patients,lines |
| R403 | T465 | T455 | prep | with,production |
| R404 | T466 | T467 | compound | CF.,Results |
| R405 | T467 | T473 | nsubjpass | Results,found |
| R406 | T468 | T471 | nmod | Bronchial,lines |
| R407 | T469 | T471 | amod | epithelial,lines |
| R408 | T470 | T471 | compound | cell,lines |
| R409 | T471 | T473 | nsubjpass | lines,found |
| R410 | T472 | T473 | auxpass | were,found |
| R411 | T473 | T452 | conj | found,examines |
| R412 | T474 | T475 | aux | to,produce |
| R413 | T475 | T473 | xcomp | produce,found |
| R414 | T476 | T477 | amod | negligible,amounts |
| R415 | T477 | T475 | dobj | amounts,produce |
| R416 | T478 | T477 | prep | of,amounts |
| R417 | T479 | T478 | pobj | basal,of |
| R418 | T480 | T477 | cc | or,amounts |
| R419 | T481 | T482 | amod | stimulated,IL-1β |
| R420 | T482 | T477 | conj | IL-1β,amounts |
| R421 | T483 | T473 | prep | compared,found |
| R422 | T484 | T483 | prep | to,compared |
| R423 | T485 | T486 | amod | hematopoeitic,cells |
| R424 | T486 | T484 | pobj | cells,to |
| R425 | T487 | T473 | cc | and,found |
| R426 | T488 | T492 | nsubj | they,upregulate |
| R427 | T489 | T492 | aux | did,upregulate |
| R428 | T490 | T492 | neg | not,upregulate |
| R429 | T491 | T492 | advmod | significantly,upregulate |
| R430 | T492 | T473 | conj | upregulate,found |
| R431 | T493 | T494 | amod | caspase-1,activity |
| R432 | T494 | T492 | dobj | activity,upregulate |
| R433 | T495 | T492 | prep | upon,upregulate |
| R434 | T496 | T497 | amod | inflammasome,stimulation |
| R435 | T497 | T495 | pobj | stimulation,upon |
| R436 | T498 | T452 | punct | .,examines |
| R437 | T499 | T516 | prep | In,produced |
| R438 | T500 | T499 | pobj | contrast,In |
| R439 | T501 | T516 | punct | ",",produced |
| R440 | T502 | T505 | amod | peripheral,cells |
| R441 | T503 | T504 | compound | blood,mononuclear |
| R442 | T504 | T505 | compound | mononuclear,cells |
| R443 | T505 | T516 | nsubj | cells,produced |
| R444 | T506 | T505 | punct | (,cells |
| R445 | T507 | T505 | appos | PBMCs,cells |
| R446 | T508 | T505 | punct | ),cells |
| R447 | T509 | T505 | prep | from,cells |
| R448 | T510 | T511 | preconj | both,CF |
| R449 | T511 | T509 | pobj | CF,from |
| R450 | T512 | T511 | cc | and,CF |
| R451 | T513 | T515 | amod | healthy,subjects |
| R452 | T514 | T515 | compound | control,subjects |
| R453 | T515 | T511 | conj | subjects,CF |
| R454 | T516 | T516 | ROOT | produced,produced |
| R455 | T517 | T518 | amod | large,amounts |
| R456 | T518 | T516 | dobj | amounts,produced |
| R457 | T519 | T518 | prep | of,amounts |
| R458 | T520 | T519 | pobj | IL-1β,of |
| R459 | T521 | T516 | cc | and,produced |
| R460 | T522 | T523 | advmod | strongly,upregulated |
| R461 | T523 | T516 | conj | upregulated,produced |
| R462 | T524 | T525 | amod | caspase-1,activity |
| R463 | T525 | T523 | dobj | activity,upregulated |
| R464 | T526 | T523 | prep | upon,upregulated |
| R465 | T527 | T528 | amod | inflammasome,stimulation |
| R466 | T528 | T526 | pobj | stimulation,upon |
| R467 | T529 | T516 | punct | .,produced |
| R468 | T530 | T536 | nsubj | PBMCs,displayed |
| R469 | T531 | T530 | prep | from,PBMCs |
| R470 | T532 | T533 | compound | CF,patients |
| R471 | T533 | T531 | pobj | patients,from |
| R472 | T534 | T533 | cc | and,patients |
| R473 | T535 | T533 | conj | controls,patients |
| R474 | T536 | T536 | ROOT | displayed,displayed |
| R475 | T537 | T538 | amod | similar,levels |
| R476 | T538 | T536 | dobj | levels,displayed |
| R477 | T539 | T538 | prep | of,levels |
| R478 | T540 | T541 | amod | caspase-1,activation |
| R479 | T541 | T539 | pobj | activation,of |
| R480 | T542 | T541 | cc | and,activation |
| R481 | T543 | T544 | amod | IL-1β,production |
| R482 | T544 | T541 | conj | production,activation |
| R483 | T545 | T546 | advmod | when,stimulated |
| R484 | T546 | T536 | advcl | stimulated,displayed |
| R485 | T547 | T546 | prep | with,stimulated |
| R486 | T548 | T549 | amod | inflammasome,activators |
| R487 | T549 | T547 | pobj | activators,with |
| R488 | T550 | T536 | punct | .,displayed |
| R489 | T551 | T553 | det | This,production |
| R490 | T552 | T553 | compound | IL-1β,production |
| R491 | T553 | T554 | nsubj | production,was |
| R492 | T554 | T554 | ROOT | was,was |
| R493 | T555 | T554 | acomp | dependent,was |
| R494 | T556 | T555 | prep | on,dependent |
| R495 | T557 | T558 | amod | NF-κB,activity |
| R496 | T558 | T556 | pobj | activity,on |
| R497 | T559 | T554 | cc | and,was |
| R498 | T560 | T562 | aux | could,enhanced |
| R499 | T561 | T562 | auxpass | be,enhanced |
| R500 | T562 | T554 | conj | enhanced,was |
| R501 | T563 | T562 | prep | by,enhanced |
| R502 | T564 | T563 | pcomp | priming,by |
| R503 | T565 | T564 | prep | with,priming |
| R504 | T566 | T565 | pobj | LPS,with |
| R505 | T567 | T554 | punct | .,was |
| R506 | T568 | T584 | advmod | Finally,alter |
| R507 | T569 | T584 | punct | ",",alter |
| R508 | T570 | T571 | compound | chemical,inhibition |
| R509 | T571 | T584 | nsubj | inhibition,alter |
| R510 | T572 | T571 | prep | of,inhibition |
| R511 | T573 | T574 | amod | CFTR,activity |
| R512 | T574 | T572 | pobj | activity,of |
| R513 | T575 | T574 | prep | in,activity |
| R514 | T576 | T575 | pobj | control,in |
| R515 | T577 | T571 | conj | PBMCs,inhibition |
| R516 | T578 | T577 | cc | and,PBMCs |
| R517 | T579 | T580 | nummod | THP-1,cells |
| R518 | T580 | T577 | conj | cells,PBMCs |
| R519 | T581 | T584 | aux | did,alter |
| R520 | T582 | T584 | neg | not,alter |
| R521 | T583 | T584 | advmod | significantly,alter |
| R522 | T584 | T584 | ROOT | alter,alter |
| R523 | T585 | T588 | amod | IL-1β,production |
| R524 | T586 | T585 | cc | or,IL-1β |
| R525 | T587 | T585 | conj | IL-8,IL-1β |
| R526 | T588 | T584 | dobj | production,alter |
| R527 | T589 | T584 | prep | in,alter |
| R528 | T590 | T589 | pobj | response,in |
| R529 | T591 | T590 | prep | to,response |
| R530 | T592 | T593 | compound | P.,aeruginosa |
| R531 | T593 | T591 | pobj | aeruginosa,to |
| R532 | T594 | T584 | punct | .,alter |
| R533 | T595 | T596 | compound | Conclusion,Hematopoeitic |
| R534 | T596 | T597 | compound | Hematopoeitic,cells |
| R535 | T597 | T598 | nsubj | cells,appear |
| R536 | T598 | T598 | ROOT | appear,appear |
| R537 | T599 | T600 | aux | to,be |
| R538 | T600 | T598 | xcomp | be,appear |
| R539 | T601 | T603 | det | the,source |
| R540 | T602 | T603 | amod | predominant,source |
| R541 | T603 | T600 | attr | source,be |
| R542 | T604 | T603 | prep | of,source |
| R543 | T605 | T607 | amod | inflammasome-induced,IL-1β |
| R544 | T606 | T607 | amod | pro-inflammatory,IL-1β |
| R545 | T607 | T604 | pobj | IL-1β,of |
| R546 | T608 | T607 | prep | in,IL-1β |
| R547 | T609 | T610 | compound | CF.,PBMCs |
| R548 | T610 | T608 | pobj | PBMCs,in |
| R549 | T611 | T598 | advcl | derived,appear |
| R550 | T612 | T611 | prep | from,derived |
| R551 | T613 | T614 | compound | CF,subjects |
| R552 | T614 | T612 | pobj | subjects,from |
| R553 | T615 | T611 | dobj | display,derived |
| R554 | T616 | T618 | amod | preserved,activation |
| R555 | T617 | T618 | amod | inflammasome,activation |
| R556 | T618 | T615 | dobj | activation,display |
| R557 | T619 | T618 | cc | and,activation |
| R558 | T620 | T621 | amod | IL-1β,secretion |
| R559 | T621 | T618 | conj | secretion,activation |
| R560 | T622 | T615 | prep | in,display |
| R561 | T623 | T622 | pobj | response,in |
| R562 | T624 | T623 | prep | to,response |
| R563 | T625 | T628 | det | the,pathogen |
| R564 | T626 | T628 | amod | major,pathogen |
| R565 | T627 | T628 | compound | CF,pathogen |
| R566 | T628 | T624 | pobj | pathogen,to |
| R567 | T629 | T630 | compound | Pseudomonas,aeruginosa |
| R568 | T630 | T628 | appos | aeruginosa,pathogen |
| R569 | T631 | T598 | punct | .,appear |
| R570 | T632 | T638 | advmod | However,support |
| R571 | T633 | T638 | punct | ",",support |
| R572 | T634 | T635 | poss | our,data |
| R573 | T635 | T638 | nsubj | data,support |
| R574 | T636 | T638 | aux | do,support |
| R575 | T637 | T638 | neg | not,support |
| R576 | T638 | T638 | ROOT | support,support |
| R577 | T639 | T640 | det | the,hypothesis |
| R578 | T640 | T638 | dobj | hypothesis,support |
| R579 | T641 | T642 | nsubj | that,increased |
| R580 | T642 | T640 | relcl | increased,hypothesis |
| R581 | T643 | T644 | amod | IL-1β,production |
| R582 | T644 | T642 | dobj | production,increased |
| R583 | T645 | T644 | prep | in,production |
| R584 | T646 | T647 | compound | CF,subjects |
| R585 | T647 | T645 | pobj | subjects,in |
| R586 | T648 | T638 | advcl | is,support |
| R587 | T649 | T648 | acomp | due,is |
| R588 | T650 | T649 | prep | to,due |
| R589 | T651 | T653 | det | an,increase |
| R590 | T652 | T653 | amod | intrinsic,increase |
| R591 | T653 | T650 | pobj | increase,to |
| R592 | T654 | T653 | prep | in,increase |
| R593 | T655 | T656 | amod | NF-κB,activity |
| R594 | T656 | T654 | pobj | activity,in |
| R595 | T657 | T653 | prep | through,increase |
| R596 | T658 | T657 | pobj | loss,through |
| R597 | T659 | T658 | prep | of,loss |
| R598 | T660 | T661 | amod | CFTR,function |
| R599 | T661 | T659 | pobj | function,of |
| R600 | T662 | T638 | punct | .,support |
pmc-enju-pas
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T97 | 0-10 | NN | denotes | Background |
| T98 | 11-23 | NN | denotes | Inflammation |
| T99 | 24-27 | CC | denotes | and |
| T100 | 28-37 | NN | denotes | infection |
| T101 | 38-41 | VB | denotes | are |
| T102 | 42-47 | JJ | denotes | major |
| T103 | 48-60 | NN | denotes | determinants |
| T104 | 61-63 | IN | denotes | of |
| T105 | 64-71 | NN | denotes | disease |
| T106 | 72-80 | NN | denotes | severity |
| T107 | 81-84 | CC | denotes | and |
| T108 | 85-97 | RB | denotes | consequently |
| T109 | 97-98 | -COMMA- | denotes | , |
| T110 | 99-102 | DT | denotes | the |
| T111 | 103-110 | NN | denotes | quality |
| T112 | 111-113 | IN | denotes | of |
| T113 | 114-118 | NN | denotes | life |
| T114 | 119-122 | CC | denotes | and |
| T115 | 123-130 | NN | denotes | outcome |
| T116 | 131-134 | IN | denotes | for |
| T117 | 135-143 | NN | denotes | patients |
| T118 | 144-148 | IN | denotes | with |
| T119 | 149-155 | JJ | denotes | cystic |
| T120 | 156-164 | NN | denotes | fibrosis |
| T121 | 165-166 | -LRB- | denotes | ( |
| T122 | 166-168 | NN | denotes | CF |
| T123 | 168-169 | -RRB- | denotes | ) |
| T124 | 171-184 | NN | denotes | Interleukin-1 |
| T125 | 185-189 | NN | denotes | beta |
| T126 | 190-191 | -LRB- | denotes | ( |
| T127 | 191-196 | NN | denotes | IL-1β |
| T128 | 196-197 | -RRB- | denotes | ) |
| T129 | 198-200 | VB | denotes | is |
| T130 | 201-202 | DT | denotes | a |
| T131 | 203-206 | JJ | denotes | key |
| T132 | 207-219 | JJ | denotes | inflammatory |
| T133 | 220-228 | NN | denotes | mediator |
| T134 | 230-239 | NN | denotes | Secretion |
| T135 | 240-242 | IN | denotes | of |
| T136 | 243-255 | RB | denotes | biologically |
| T137 | 256-262 | JJ | denotes | active |
| T138 | 263-268 | NN | denotes | IL-1β |
| T139 | 269-277 | VB | denotes | involves |
| T140 | 278-299 | JJ | denotes | inflammasome-mediated |
| T141 | 300-310 | NN | denotes | processing |
| T142 | 312-318 | JJ | denotes | Little |
| T143 | 319-321 | VB | denotes | is |
| T144 | 322-327 | VB | denotes | known |
| T145 | 328-333 | IN | denotes | about |
| T146 | 334-337 | DT | denotes | the |
| T147 | 338-350 | NN | denotes | contribution |
| T148 | 351-353 | IN | denotes | of |
| T149 | 354-359 | NN | denotes | IL-1β |
| T150 | 360-363 | CC | denotes | and |
| T151 | 364-367 | DT | denotes | the |
| T152 | 368-381 | NN | denotes | inflammasomes |
| T153 | 382-384 | IN | denotes | in |
| T154 | 385-387 | NN | denotes | CF |
| T155 | 388-400 | JJ | denotes | inflammatory |
| T156 | 401-408 | NN | denotes | disease |
| T157 | 410-414 | DT | denotes | This |
| T158 | 415-420 | NN | denotes | study |
| T159 | 421-429 | VB | denotes | examines |
| T160 | 430-451 | JJ | denotes | inflammasome-mediated |
| T161 | 452-457 | NN | denotes | IL-1β |
| T162 | 458-468 | NN | denotes | production |
| T163 | 469-471 | IN | denotes | in |
| T164 | 472-474 | NN | denotes | CF |
| T165 | 475-484 | JJ | denotes | bronchial |
| T166 | 485-495 | JJ | denotes | epithelial |
| T167 | 496-500 | NN | denotes | cell |
| T168 | 501-506 | NN | denotes | lines |
| T169 | 507-510 | CC | denotes | and |
| T170 | 511-516 | JJ | denotes | human |
| T171 | 517-525 | NN | denotes | patients |
| T172 | 526-530 | IN | denotes | with |
| T173 | 531-533 | NN | denotes | CF |
| T174 | 536-543 | NN | denotes | Results |
| T175 | 544-553 | JJ | denotes | Bronchial |
| T176 | 554-564 | JJ | denotes | epithelial |
| T177 | 565-569 | NN | denotes | cell |
| T178 | 570-575 | NN | denotes | lines |
| T179 | 576-580 | VB | denotes | were |
| T180 | 581-586 | VB | denotes | found |
| T181 | 587-589 | TO | denotes | to |
| T182 | 590-597 | VB | denotes | produce |
| T183 | 598-608 | JJ | denotes | negligible |
| T184 | 609-616 | NN | denotes | amounts |
| T185 | 617-619 | IN | denotes | of |
| T186 | 620-625 | JJ | denotes | basal |
| T187 | 626-628 | CC | denotes | or |
| T188 | 629-639 | VB | denotes | stimulated |
| T189 | 640-645 | NN | denotes | IL-1β |
| T190 | 646-654 | VB | denotes | compared |
| T191 | 655-657 | TO | denotes | to |
| T192 | 658-671 | JJ | denotes | hematopoeitic |
| T193 | 672-677 | NN | denotes | cells |
| T194 | 678-681 | CC | denotes | and |
| T195 | 682-686 | PRP | denotes | they |
| T196 | 687-690 | VB | denotes | did |
| T197 | 691-694 | RB | denotes | not |
| T198 | 695-708 | RB | denotes | significantly |
| T199 | 709-719 | VB | denotes | upregulate |
| T200 | 720-729 | NN | denotes | caspase-1 |
| T201 | 730-738 | NN | denotes | activity |
| T202 | 739-743 | IN | denotes | upon |
| T203 | 744-756 | JJ | denotes | inflammasome |
| T204 | 757-768 | NN | denotes | stimulation |
| T205 | 770-772 | IN | denotes | In |
| T206 | 773-781 | NN | denotes | contrast |
| T207 | 781-782 | -COMMA- | denotes | , |
| T208 | 783-793 | JJ | denotes | peripheral |
| T209 | 794-799 | NN | denotes | blood |
| T210 | 800-811 | JJ | denotes | mononuclear |
| T211 | 812-817 | NN | denotes | cells |
| T212 | 818-819 | -LRB- | denotes | ( |
| T213 | 819-824 | NN | denotes | PBMCs |
| T214 | 824-825 | -RRB- | denotes | ) |
| T215 | 826-830 | IN | denotes | from |
| T216 | 831-835 | CC | denotes | both |
| T217 | 836-838 | NN | denotes | CF |
| T218 | 839-842 | CC | denotes | and |
| T219 | 843-850 | JJ | denotes | healthy |
| T220 | 851-858 | NN | denotes | control |
| T221 | 859-867 | NN | denotes | subjects |
| T222 | 868-876 | VB | denotes | produced |
| T223 | 877-882 | JJ | denotes | large |
| T224 | 883-890 | NN | denotes | amounts |
| T225 | 891-893 | IN | denotes | of |
| T226 | 894-899 | NN | denotes | IL-1β |
| T227 | 900-903 | CC | denotes | and |
| T228 | 904-912 | RB | denotes | strongly |
| T229 | 913-924 | VB | denotes | upregulated |
| T230 | 925-934 | NN | denotes | caspase-1 |
| T231 | 935-943 | NN | denotes | activity |
| T232 | 944-948 | IN | denotes | upon |
| T233 | 949-961 | JJ | denotes | inflammasome |
| T234 | 962-973 | NN | denotes | stimulation |
| T235 | 975-980 | NN | denotes | PBMCs |
| T236 | 981-985 | IN | denotes | from |
| T237 | 986-988 | NN | denotes | CF |
| T238 | 989-997 | NN | denotes | patients |
| T239 | 998-1001 | CC | denotes | and |
| T240 | 1002-1010 | NN | denotes | controls |
| T241 | 1011-1020 | VB | denotes | displayed |
| T242 | 1021-1028 | JJ | denotes | similar |
| T243 | 1029-1035 | NN | denotes | levels |
| T244 | 1036-1038 | IN | denotes | of |
| T245 | 1039-1048 | NN | denotes | caspase-1 |
| T246 | 1049-1059 | NN | denotes | activation |
| T247 | 1060-1063 | CC | denotes | and |
| T248 | 1064-1069 | NN | denotes | IL-1β |
| T249 | 1070-1080 | NN | denotes | production |
| T250 | 1081-1085 | WRB | denotes | when |
| T251 | 1086-1096 | VB | denotes | stimulated |
| T252 | 1097-1101 | IN | denotes | with |
| T253 | 1102-1114 | JJ | denotes | inflammasome |
| T254 | 1115-1125 | NN | denotes | activators |
| T255 | 1127-1131 | DT | denotes | This |
| T256 | 1132-1137 | NN | denotes | IL-1β |
| T257 | 1138-1148 | NN | denotes | production |
| T258 | 1149-1152 | VB | denotes | was |
| T259 | 1153-1162 | JJ | denotes | dependent |
| T260 | 1163-1165 | IN | denotes | on |
| T261 | 1166-1171 | NN | denotes | NF-κB |
| T262 | 1172-1180 | NN | denotes | activity |
| T263 | 1181-1184 | CC | denotes | and |
| T264 | 1185-1190 | MD | denotes | could |
| T265 | 1191-1193 | VB | denotes | be |
| T266 | 1194-1202 | VB | denotes | enhanced |
| T267 | 1203-1205 | IN | denotes | by |
| T268 | 1206-1213 | VB | denotes | priming |
| T269 | 1214-1218 | IN | denotes | with |
| T270 | 1219-1222 | NN | denotes | LPS |
| T271 | 1224-1231 | RB | denotes | Finally |
| T272 | 1231-1232 | -COMMA- | denotes | , |
| T273 | 1233-1241 | JJ | denotes | chemical |
| T274 | 1242-1252 | NN | denotes | inhibition |
| T275 | 1253-1255 | IN | denotes | of |
| T276 | 1256-1260 | NN | denotes | CFTR |
| T277 | 1261-1269 | NN | denotes | activity |
| T278 | 1270-1272 | IN | denotes | in |
| T279 | 1273-1280 | NN | denotes | control |
| T280 | 1281-1286 | NN | denotes | PBMCs |
| T281 | 1287-1290 | CC | denotes | and |
| T282 | 1291-1296 | NN | denotes | THP-1 |
| T283 | 1297-1302 | NN | denotes | cells |
| T284 | 1303-1306 | VB | denotes | did |
| T285 | 1307-1310 | RB | denotes | not |
| T286 | 1311-1324 | RB | denotes | significantly |
| T287 | 1325-1330 | VB | denotes | alter |
| T288 | 1331-1336 | NN | denotes | IL-1β |
| T289 | 1337-1339 | CC | denotes | or |
| T290 | 1340-1344 | NN | denotes | IL-8 |
| T291 | 1345-1355 | NN | denotes | production |
| T292 | 1356-1358 | IN | denotes | in |
| T293 | 1359-1367 | NN | denotes | response |
| T294 | 1368-1370 | TO | denotes | to |
| T295 | 1371-1373 | NNP | denotes | P. |
| T296 | 1374-1384 | NN | denotes | aeruginosa |
| T297 | 1387-1397 | NN | denotes | Conclusion |
| T298 | 1398-1411 | JJ | denotes | Hematopoeitic |
| T299 | 1412-1417 | NN | denotes | cells |
| T300 | 1418-1424 | VB | denotes | appear |
| T301 | 1425-1427 | TO | denotes | to |
| T302 | 1428-1430 | VB | denotes | be |
| T303 | 1431-1434 | DT | denotes | the |
| T304 | 1435-1446 | JJ | denotes | predominant |
| T305 | 1447-1453 | NN | denotes | source |
| T306 | 1454-1456 | IN | denotes | of |
| T307 | 1457-1477 | JJ | denotes | inflammasome-induced |
| T308 | 1478-1494 | JJ | denotes | pro-inflammatory |
| T309 | 1495-1500 | NN | denotes | IL-1β |
| T310 | 1501-1503 | IN | denotes | in |
| T311 | 1504-1506 | NN | denotes | CF |
| T312 | 1508-1513 | NN | denotes | PBMCs |
| T313 | 1514-1521 | VB | denotes | derived |
| T314 | 1522-1526 | IN | denotes | from |
| T315 | 1527-1529 | NN | denotes | CF |
| T316 | 1530-1538 | NN | denotes | subjects |
| T317 | 1539-1546 | VB | denotes | display |
| T318 | 1547-1556 | VB | denotes | preserved |
| T319 | 1557-1569 | JJ | denotes | inflammasome |
| T320 | 1570-1580 | NN | denotes | activation |
| T321 | 1581-1584 | CC | denotes | and |
| T322 | 1585-1590 | NN | denotes | IL-1β |
| T323 | 1591-1600 | NN | denotes | secretion |
| T324 | 1601-1603 | IN | denotes | in |
| T325 | 1604-1612 | NN | denotes | response |
| T326 | 1613-1615 | TO | denotes | to |
| T327 | 1616-1619 | DT | denotes | the |
| T328 | 1620-1625 | JJ | denotes | major |
| T329 | 1626-1628 | NN | denotes | CF |
| T330 | 1629-1637 | NN | denotes | pathogen |
| T331 | 1638-1649 | NN | denotes | Pseudomonas |
| T332 | 1650-1660 | NN | denotes | aeruginosa |
| T333 | 1662-1669 | RB | denotes | However |
| T334 | 1669-1670 | -COMMA- | denotes | , |
| T335 | 1671-1674 | PRP-DOLLAR- | denotes | our |
| T336 | 1675-1679 | NN | denotes | data |
| T337 | 1680-1682 | VB | denotes | do |
| T338 | 1683-1686 | RB | denotes | not |
| T339 | 1687-1694 | VB | denotes | support |
| T340 | 1695-1698 | DT | denotes | the |
| T341 | 1699-1709 | NN | denotes | hypothesis |
| T342 | 1710-1714 | IN | denotes | that |
| T343 | 1715-1724 | VB | denotes | increased |
| T344 | 1725-1730 | NN | denotes | IL-1β |
| T345 | 1731-1741 | NN | denotes | production |
| T346 | 1742-1744 | IN | denotes | in |
| T347 | 1745-1747 | NN | denotes | CF |
| T348 | 1748-1756 | NN | denotes | subjects |
| T349 | 1757-1759 | VB | denotes | is |
| T350 | 1760-1763 | JJ | denotes | due |
| T351 | 1764-1766 | TO | denotes | to |
| T352 | 1767-1769 | DT | denotes | an |
| T353 | 1770-1779 | JJ | denotes | intrinsic |
| T354 | 1780-1788 | NN | denotes | increase |
| T355 | 1789-1791 | IN | denotes | in |
| T356 | 1792-1797 | NN | denotes | NF-κB |
| T357 | 1798-1806 | NN | denotes | activity |
| T358 | 1807-1814 | IN | denotes | through |
| T359 | 1815-1819 | NN | denotes | loss |
| T360 | 1820-1822 | IN | denotes | of |
| T361 | 1823-1827 | NN | denotes | CFTR |
| T362 | 1828-1836 | NN | denotes | function |
| R52 | T98 | T99 | arg1Of | Inflammation,and |
| R53 | T99 | T101 | arg1Of | and,are |
| R54 | T100 | T99 | arg2Of | infection,and |
| R55 | T103 | T101 | arg2Of | determinants,are |
| R56 | T103 | T102 | arg1Of | determinants,major |
| R57 | T103 | T104 | arg1Of | determinants,of |
| R58 | T103 | T108 | arg1Of | determinants,consequently |
| R59 | T103 | T109 | arg1Of | determinants,"," |
| R60 | T104 | T107 | arg1Of | of,and |
| R61 | T106 | T104 | arg2Of | severity,of |
| R62 | T106 | T105 | arg1Of | severity,disease |
| R63 | T108 | T107 | arg2Of | consequently,and |
| R64 | T111 | T109 | arg2Of | quality,"," |
| R65 | T111 | T110 | arg1Of | quality,the |
| R66 | T111 | T112 | arg1Of | quality,of |
| R67 | T111 | T116 | arg1Of | quality,for |
| R68 | T113 | T114 | arg1Of | life,and |
| R69 | T114 | T112 | arg2Of | and,of |
| R70 | T115 | T114 | arg2Of | outcome,and |
| R71 | T117 | T116 | arg2Of | patients,for |
| R72 | T117 | T118 | arg1Of | patients,with |
| R73 | T120 | T118 | arg2Of | fibrosis,with |
| R74 | T120 | T119 | arg1Of | fibrosis,cystic |
| R75 | T120 | T121 | arg1Of | fibrosis,( |
| R76 | T122 | T121 | arg2Of | CF,( |
| R77 | T123 | T121 | arg3Of | ),( |
| R78 | T125 | T124 | arg1Of | beta,Interleukin-1 |
| R79 | T125 | T126 | arg1Of | beta,( |
| R80 | T125 | T129 | arg1Of | beta,is |
| R81 | T127 | T126 | arg2Of | IL-1β,( |
| R82 | T128 | T126 | arg3Of | ),( |
| R83 | T133 | T129 | arg2Of | mediator,is |
| R84 | T133 | T130 | arg1Of | mediator,a |
| R85 | T133 | T131 | arg1Of | mediator,key |
| R86 | T133 | T132 | arg1Of | mediator,inflammatory |
| R87 | T134 | T135 | arg1Of | Secretion,of |
| R88 | T134 | T139 | arg1Of | Secretion,involves |
| R89 | T137 | T136 | arg1Of | active,biologically |
| R90 | T138 | T135 | arg2Of | IL-1β,of |
| R91 | T138 | T137 | arg1Of | IL-1β,active |
| R92 | T141 | T139 | arg2Of | processing,involves |
| R93 | T141 | T140 | arg1Of | processing,inflammasome-mediated |
| R94 | T142 | T143 | arg1Of | Little,is |
| R95 | T142 | T144 | arg2Of | Little,known |
| R96 | T144 | T143 | arg2Of | known,is |
| R97 | T144 | T145 | arg1Of | known,about |
| R98 | T147 | T145 | arg2Of | contribution,about |
| R99 | T147 | T146 | arg1Of | contribution,the |
| R100 | T147 | T148 | arg1Of | contribution,of |
| R101 | T147 | T153 | arg1Of | contribution,in |
| R102 | T149 | T150 | arg1Of | IL-1β,and |
| R103 | T150 | T148 | arg2Of | and,of |
| R104 | T152 | T150 | arg2Of | inflammasomes,and |
| R105 | T152 | T151 | arg1Of | inflammasomes,the |
| R106 | T156 | T153 | arg2Of | disease,in |
| R107 | T156 | T154 | arg1Of | disease,CF |
| R108 | T156 | T155 | arg1Of | disease,inflammatory |
| R109 | T158 | T157 | arg1Of | study,This |
| R110 | T158 | T159 | arg1Of | study,examines |
| R111 | T162 | T159 | arg2Of | production,examines |
| R112 | T162 | T160 | arg1Of | production,inflammasome-mediated |
| R113 | T162 | T161 | arg1Of | production,IL-1β |
| R114 | T162 | T163 | arg1Of | production,in |
| R115 | T168 | T164 | arg1Of | lines,CF |
| R116 | T168 | T165 | arg1Of | lines,bronchial |
| R117 | T168 | T166 | arg1Of | lines,epithelial |
| R118 | T168 | T167 | arg1Of | lines,cell |
| R119 | T168 | T169 | arg1Of | lines,and |
| R120 | T169 | T163 | arg2Of | and,in |
| R121 | T171 | T169 | arg2Of | patients,and |
| R122 | T171 | T170 | arg1Of | patients,human |
| R123 | T171 | T172 | arg1Of | patients,with |
| R124 | T173 | T172 | arg2Of | CF,with |
| R125 | T178 | T175 | arg1Of | lines,Bronchial |
| R126 | T178 | T176 | arg1Of | lines,epithelial |
| R127 | T178 | T177 | arg1Of | lines,cell |
| R128 | T178 | T179 | arg1Of | lines,were |
| R129 | T178 | T180 | arg2Of | lines,found |
| R130 | T178 | T182 | arg1Of | lines,produce |
| R131 | T180 | T179 | arg2Of | found,were |
| R132 | T180 | T190 | arg1Of | found,compared |
| R133 | T180 | T194 | arg1Of | found,and |
| R134 | T182 | T180 | arg3Of | produce,found |
| R135 | T182 | T181 | arg1Of | produce,to |
| R136 | T184 | T182 | arg2Of | amounts,produce |
| R137 | T184 | T183 | arg1Of | amounts,negligible |
| R138 | T184 | T185 | arg1Of | amounts,of |
| R139 | T186 | T187 | arg1Of | basal,or |
| R140 | T186 | T188 | arg2Of | basal,stimulated |
| R141 | T189 | T185 | arg2Of | IL-1β,of |
| R142 | T189 | T186 | arg1Of | IL-1β,basal |
| R143 | T191 | T190 | arg2Of | to,compared |
| R144 | T193 | T191 | arg2Of | cells,to |
| R145 | T193 | T192 | arg1Of | cells,hematopoeitic |
| R146 | T195 | T196 | arg1Of | they,did |
| R147 | T195 | T199 | arg1Of | they,upregulate |
| R148 | T199 | T194 | arg2Of | upregulate,and |
| R149 | T199 | T196 | arg2Of | upregulate,did |
| R150 | T199 | T197 | arg1Of | upregulate,not |
| R151 | T199 | T198 | arg1Of | upregulate,significantly |
| R152 | T199 | T202 | arg1Of | upregulate,upon |
| R153 | T201 | T199 | arg2Of | activity,upregulate |
| R154 | T201 | T200 | arg1Of | activity,caspase-1 |
| R155 | T204 | T202 | arg2Of | stimulation,upon |
| R156 | T204 | T203 | arg1Of | stimulation,inflammasome |
| R157 | T206 | T205 | arg2Of | contrast,In |
| R158 | T211 | T208 | arg1Of | cells,peripheral |
| R159 | T211 | T209 | arg1Of | cells,blood |
| R160 | T211 | T210 | arg1Of | cells,mononuclear |
| R161 | T211 | T212 | arg1Of | cells,( |
| R162 | T211 | T215 | arg1Of | cells,from |
| R163 | T211 | T222 | arg1Of | cells,produced |
| R164 | T213 | T212 | arg2Of | PBMCs,( |
| R165 | T214 | T212 | arg3Of | ),( |
| R166 | T221 | T215 | arg2Of | subjects,from |
| R167 | T221 | T216 | arg1Of | subjects,both |
| R168 | T221 | T217 | arg1Of | subjects,CF |
| R169 | T221 | T218 | arg1Of | subjects,and |
| R170 | T221 | T219 | arg1Of | subjects,healthy |
| R171 | T221 | T220 | arg1Of | subjects,control |
| R172 | T222 | T205 | arg1Of | produced,In |
| R173 | T222 | T207 | arg1Of | produced,"," |
| R174 | T224 | T222 | arg2Of | amounts,produced |
| R175 | T224 | T223 | arg1Of | amounts,large |
| R176 | T224 | T225 | arg1Of | amounts,of |
| R177 | T226 | T227 | arg1Of | IL-1β,and |
| R178 | T227 | T225 | arg2Of | and,of |
| R179 | T227 | T232 | arg1Of | and,upon |
| R180 | T229 | T228 | arg1Of | upregulated,strongly |
| R181 | T231 | T227 | arg2Of | activity,and |
| R182 | T231 | T229 | arg2Of | activity,upregulated |
| R183 | T231 | T230 | arg1Of | activity,caspase-1 |
| R184 | T234 | T232 | arg2Of | stimulation,upon |
| R185 | T234 | T233 | arg1Of | stimulation,inflammasome |
| R186 | T235 | T236 | arg1Of | PBMCs,from |
| R187 | T235 | T241 | arg1Of | PBMCs,displayed |
| R188 | T238 | T237 | arg1Of | patients,CF |
| R189 | T238 | T239 | arg1Of | patients,and |
| R190 | T239 | T236 | arg2Of | and,from |
| R191 | T240 | T239 | arg2Of | controls,and |
| R192 | T241 | T250 | arg1Of | displayed,when |
| R193 | T243 | T241 | arg2Of | levels,displayed |
| R194 | T243 | T242 | arg1Of | levels,similar |
| R195 | T243 | T244 | arg1Of | levels,of |
| R196 | T246 | T245 | arg1Of | activation,caspase-1 |
| R197 | T246 | T247 | arg1Of | activation,and |
| R198 | T247 | T244 | arg2Of | and,of |
| R199 | T249 | T247 | arg2Of | production,and |
| R200 | T249 | T248 | arg1Of | production,IL-1β |
| R201 | T251 | T250 | arg2Of | stimulated,when |
| R202 | T251 | T252 | arg1Of | stimulated,with |
| R203 | T254 | T252 | arg2Of | activators,with |
| R204 | T254 | T253 | arg1Of | activators,inflammasome |
| R205 | T257 | T255 | arg1Of | production,This |
| R206 | T257 | T256 | arg1Of | production,IL-1β |
| R207 | T257 | T258 | arg1Of | production,was |
| R208 | T257 | T259 | arg1Of | production,dependent |
| R209 | T257 | T264 | arg1Of | production,could |
| R210 | T257 | T265 | arg1Of | production,be |
| R211 | T257 | T266 | arg2Of | production,enhanced |
| R212 | T258 | T263 | arg1Of | was,and |
| R213 | T259 | T258 | arg2Of | dependent,was |
| R214 | T259 | T260 | arg1Of | dependent,on |
| R215 | T262 | T260 | arg2Of | activity,on |
| R216 | T262 | T261 | arg1Of | activity,NF-κB |
| R217 | T266 | T263 | arg2Of | enhanced,and |
| R218 | T266 | T264 | arg2Of | enhanced,could |
| R219 | T266 | T265 | arg2Of | enhanced,be |
| R220 | T266 | T267 | arg1Of | enhanced,by |
| R221 | T268 | T267 | arg2Of | priming,by |
| R222 | T268 | T269 | arg1Of | priming,with |
| R223 | T270 | T269 | arg2Of | LPS,with |
| R224 | T274 | T273 | arg1Of | inhibition,chemical |
| R225 | T274 | T275 | arg1Of | inhibition,of |
| R226 | T274 | T278 | arg1Of | inhibition,in |
| R227 | T274 | T284 | arg1Of | inhibition,did |
| R228 | T274 | T287 | arg1Of | inhibition,alter |
| R229 | T277 | T275 | arg2Of | activity,of |
| R230 | T277 | T276 | arg1Of | activity,CFTR |
| R231 | T280 | T279 | arg1Of | PBMCs,control |
| R232 | T280 | T281 | arg1Of | PBMCs,and |
| R233 | T281 | T278 | arg2Of | and,in |
| R234 | T283 | T281 | arg2Of | cells,and |
| R235 | T283 | T282 | arg1Of | cells,THP-1 |
| R236 | T287 | T271 | arg1Of | alter,Finally |
| R237 | T287 | T272 | arg1Of | alter,"," |
| R238 | T287 | T284 | arg2Of | alter,did |
| R239 | T287 | T285 | arg1Of | alter,not |
| R240 | T287 | T286 | arg1Of | alter,significantly |
| R241 | T287 | T292 | arg1Of | alter,in |
| R242 | T288 | T289 | arg1Of | IL-1β,or |
| R243 | T290 | T289 | arg2Of | IL-8,or |
| R244 | T291 | T287 | arg2Of | production,alter |
| R245 | T291 | T288 | arg1Of | production,IL-1β |
| R246 | T291 | T290 | arg1Of | production,IL-8 |
| R247 | T293 | T292 | arg2Of | response,in |
| R248 | T293 | T294 | arg1Of | response,to |
| R249 | T296 | T294 | arg2Of | aeruginosa,to |
| R250 | T296 | T295 | arg1Of | aeruginosa,P. |
| R251 | T299 | T298 | arg1Of | cells,Hematopoeitic |
| R252 | T299 | T300 | arg1Of | cells,appear |
| R253 | T299 | T302 | arg1Of | cells,be |
| R254 | T302 | T300 | arg2Of | be,appear |
| R255 | T302 | T301 | arg1Of | be,to |
| R256 | T305 | T302 | arg2Of | source,be |
| R257 | T305 | T303 | arg1Of | source,the |
| R258 | T305 | T304 | arg1Of | source,predominant |
| R259 | T305 | T306 | arg1Of | source,of |
| R260 | T305 | T310 | arg1Of | source,in |
| R261 | T309 | T306 | arg2Of | IL-1β,of |
| R262 | T309 | T307 | arg1Of | IL-1β,inflammasome-induced |
| R263 | T309 | T308 | arg1Of | IL-1β,pro-inflammatory |
| R264 | T311 | T310 | arg2Of | CF,in |
| R265 | T312 | T313 | arg2Of | PBMCs,derived |
| R266 | T312 | T317 | arg1Of | PBMCs,display |
| R267 | T313 | T314 | arg1Of | derived,from |
| R268 | T316 | T314 | arg2Of | subjects,from |
| R269 | T316 | T315 | arg1Of | subjects,CF |
| R270 | T317 | T324 | arg1Of | display,in |
| R271 | T320 | T318 | arg2Of | activation,preserved |
| R272 | T320 | T319 | arg1Of | activation,inflammasome |
| R273 | T320 | T321 | arg1Of | activation,and |
| R274 | T321 | T317 | arg2Of | and,display |
| R275 | T323 | T321 | arg2Of | secretion,and |
| R276 | T323 | T322 | arg1Of | secretion,IL-1β |
| R277 | T324 | T326 | arg1Of | in,to |
| R278 | T325 | T324 | arg2Of | response,in |
| R279 | T332 | T324 | arg3Of | aeruginosa,in |
| R280 | T332 | T327 | arg1Of | aeruginosa,the |
| R281 | T332 | T328 | arg1Of | aeruginosa,major |
| R282 | T332 | T329 | arg1Of | aeruginosa,CF |
| R283 | T332 | T330 | arg1Of | aeruginosa,pathogen |
| R284 | T332 | T331 | arg1Of | aeruginosa,Pseudomonas |
| R285 | T336 | T335 | arg1Of | data,our |
| R286 | T336 | T337 | arg1Of | data,do |
| R287 | T336 | T339 | arg1Of | data,support |
| R288 | T339 | T333 | arg1Of | support,However |
| R289 | T339 | T334 | arg1Of | support,"," |
| R290 | T339 | T337 | arg2Of | support,do |
| R291 | T339 | T338 | arg1Of | support,not |
| R292 | T341 | T339 | arg2Of | hypothesis,support |
| R293 | T341 | T340 | arg1Of | hypothesis,the |
| R294 | T345 | T343 | arg2Of | production,increased |
| R295 | T345 | T344 | arg1Of | production,IL-1β |
| R296 | T345 | T346 | arg1Of | production,in |
| R297 | T345 | T349 | arg1Of | production,is |
| R298 | T345 | T351 | arg1Of | production,to |
| R299 | T348 | T346 | arg2Of | subjects,in |
| R300 | T348 | T347 | arg1Of | subjects,CF |
| R301 | T349 | T341 | arg2Of | is,hypothesis |
| R302 | T349 | T342 | arg1Of | is,that |
| R303 | T351 | T349 | arg2Of | to,is |
| R304 | T351 | T350 | arg1Of | to,due |
| R305 | T354 | T351 | arg2Of | increase,to |
| R306 | T354 | T352 | arg1Of | increase,an |
| R307 | T354 | T353 | arg1Of | increase,intrinsic |
| R308 | T354 | T355 | arg1Of | increase,in |
| R309 | T357 | T355 | arg2Of | activity,in |
| R310 | T357 | T356 | arg1Of | activity,NF-κB |
| R311 | T357 | T358 | arg1Of | activity,through |
| R312 | T359 | T358 | arg2Of | loss,through |
| R313 | T359 | T360 | arg1Of | loss,of |
| R314 | T362 | T360 | arg2Of | function,of |
| R315 | T362 | T361 | arg1Of | function,CFTR |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T73 | 0-10 | Sentence | denotes | Background |
| T74 | 11-170 | Sentence | denotes | Inflammation and infection are major determinants of disease severity and consequently, the quality of life and outcome for patients with cystic fibrosis (CF). |
| T75 | 171-229 | Sentence | denotes | Interleukin-1 beta (IL-1β) is a key inflammatory mediator. |
| T76 | 230-311 | Sentence | denotes | Secretion of biologically active IL-1β involves inflammasome-mediated processing. |
| T77 | 312-409 | Sentence | denotes | Little is known about the contribution of IL-1β and the inflammasomes in CF inflammatory disease. |
| T78 | 410-534 | Sentence | denotes | This study examines inflammasome-mediated IL-1β production in CF bronchial epithelial cell lines and human patients with CF. |
| T79 | 536-543 | Sentence | denotes | Results |
| T80 | 544-769 | Sentence | denotes | Bronchial epithelial cell lines were found to produce negligible amounts of basal or stimulated IL-1β compared to hematopoeitic cells and they did not significantly upregulate caspase-1 activity upon inflammasome stimulation. |
| T81 | 770-974 | Sentence | denotes | In contrast, peripheral blood mononuclear cells (PBMCs) from both CF and healthy control subjects produced large amounts of IL-1β and strongly upregulated caspase-1 activity upon inflammasome stimulation. |
| T82 | 975-1126 | Sentence | denotes | PBMCs from CF patients and controls displayed similar levels of caspase-1 activation and IL-1β production when stimulated with inflammasome activators. |
| T83 | 1127-1223 | Sentence | denotes | This IL-1β production was dependent on NF-κB activity and could be enhanced by priming with LPS. |
| T84 | 1224-1385 | Sentence | denotes | Finally, chemical inhibition of CFTR activity in control PBMCs and THP-1 cells did not significantly alter IL-1β or IL-8 production in response to P. aeruginosa. |
| T85 | 1387-1397 | Sentence | denotes | Conclusion |
| T86 | 1398-1507 | Sentence | denotes | Hematopoeitic cells appear to be the predominant source of inflammasome-induced pro-inflammatory IL-1β in CF. |
| T87 | 1508-1661 | Sentence | denotes | PBMCs derived from CF subjects display preserved inflammasome activation and IL-1β secretion in response to the major CF pathogen Pseudomonas aeruginosa. |
| T88 | 1662-1837 | Sentence | denotes | However, our data do not support the hypothesis that increased IL-1β production in CF subjects is due to an intrinsic increase in NF-κB activity through loss of CFTR function. |
| T3 | 0-10 | Sentence | denotes | Background |
| T4 | 11-170 | Sentence | denotes | Inflammation and infection are major determinants of disease severity and consequently, the quality of life and outcome for patients with cystic fibrosis (CF). |
| T5 | 171-229 | Sentence | denotes | Interleukin-1 beta (IL-1β) is a key inflammatory mediator. |
| T6 | 230-311 | Sentence | denotes | Secretion of biologically active IL-1β involves inflammasome-mediated processing. |
| T7 | 312-409 | Sentence | denotes | Little is known about the contribution of IL-1β and the inflammasomes in CF inflammatory disease. |
| T8 | 410-534 | Sentence | denotes | This study examines inflammasome-mediated IL-1β production in CF bronchial epithelial cell lines and human patients with CF. |
| T9 | 536-543 | Sentence | denotes | Results |
| T10 | 544-769 | Sentence | denotes | Bronchial epithelial cell lines were found to produce negligible amounts of basal or stimulated IL-1β compared to hematopoeitic cells and they did not significantly upregulate caspase-1 activity upon inflammasome stimulation. |
| T11 | 770-974 | Sentence | denotes | In contrast, peripheral blood mononuclear cells (PBMCs) from both CF and healthy control subjects produced large amounts of IL-1β and strongly upregulated caspase-1 activity upon inflammasome stimulation. |
| T12 | 975-1126 | Sentence | denotes | PBMCs from CF patients and controls displayed similar levels of caspase-1 activation and IL-1β production when stimulated with inflammasome activators. |
| T13 | 1127-1223 | Sentence | denotes | This IL-1β production was dependent on NF-κB activity and could be enhanced by priming with LPS. |
| T14 | 1224-1385 | Sentence | denotes | Finally, chemical inhibition of CFTR activity in control PBMCs and THP-1 cells did not significantly alter IL-1β or IL-8 production in response to P. aeruginosa. |
| T15 | 1387-1397 | Sentence | denotes | Conclusion |
| T16 | 1398-1507 | Sentence | denotes | Hematopoeitic cells appear to be the predominant source of inflammasome-induced pro-inflammatory IL-1β in CF. |
| T17 | 1508-1661 | Sentence | denotes | PBMCs derived from CF subjects display preserved inflammasome activation and IL-1β secretion in response to the major CF pathogen Pseudomonas aeruginosa. |
| T18 | 1662-1837 | Sentence | denotes | However, our data do not support the hypothesis that increased IL-1β production in CF subjects is due to an intrinsic increase in NF-κB activity through loss of CFTR function. |