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PMC:3333881 / 1994-2248
Annnotations
pmc-enju-pas
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1561 | 0-2 | IN | denotes | In |
T1562 | 3-6 | DT | denotes | the |
T1563 | 7-16 | JJ | denotes | canonical |
T1564 | 17-24 | NN | denotes | pathway |
T1565 | 25-27 | IN | denotes | of |
T1566 | 28-33 | NN | denotes | NF-κB |
T1567 | 34-44 | NN | denotes | activation |
T1568 | 44-45 | -COMMA- | denotes | , |
T1569 | 46-49 | DT | denotes | the |
T1570 | 50-59 | VB | denotes | activated |
T1571 | 60-63 | NN | denotes | IκB |
T1572 | 64-70 | NN | denotes | kinase |
T1573 | 71-72 | -LRB- | denotes | ( |
T1574 | 72-75 | NN | denotes | IKK |
T1575 | 75-76 | -RRB- | denotes | ) |
T1576 | 77-91 | VB | denotes | phosphorylates |
T1577 | 92-95 | NN | denotes | IκB |
T1578 | 96-98 | IN | denotes | at |
T1579 | 99-107 | JJ | denotes | specific |
T1580 | 108-114 | NN | denotes | serine |
T1581 | 115-123 | NN | denotes | residues |
T1582 | 124-128 | WDT | denotes | that |
T1583 | 129-135 | VB | denotes | target |
T1584 | 136-139 | DT | denotes | the |
T1585 | 140-147 | NN | denotes | protein |
T1586 | 148-150 | TO | denotes | to |
T1587 | 151-165 | NN | denotes | ubiquitination |
T1588 | 166-169 | CC | denotes | and |
T1589 | 170-181 | JJ | denotes | proteasomal |
T1590 | 182-193 | NN | denotes | degradation |
T1591 | 193-194 | -COMMA- | denotes | , |
T1592 | 195-200 | WDT | denotes | which |
T1593 | 201-209 | VB | denotes | releases |
T1594 | 210-213 | DT | denotes | the |
T1595 | 214-224 | JJ | denotes | functional |
T1596 | 225-230 | NN | denotes | NF-κB |
T1597 | 231-238 | NN | denotes | complex |
T1598 | 239-241 | IN | denotes | in |
T1599 | 242-245 | DT | denotes | the |
T1600 | 246-253 | NN | denotes | nucleus |
R1382 | T1564 | T1561 | arg2Of | pathway,In |
R1383 | T1564 | T1562 | arg1Of | pathway,the |
R1384 | T1564 | T1563 | arg1Of | pathway,canonical |
R1385 | T1564 | T1565 | arg1Of | pathway,of |
R1386 | T1567 | T1565 | arg2Of | activation,of |
R1387 | T1567 | T1566 | arg1Of | activation,NF-κB |
R1388 | T1572 | T1569 | arg1Of | kinase,the |
R1389 | T1572 | T1570 | arg2Of | kinase,activated |
R1390 | T1572 | T1571 | arg1Of | kinase,IκB |
R1391 | T1572 | T1573 | arg1Of | kinase,( |
R1392 | T1572 | T1576 | arg1Of | kinase,phosphorylates |
R1393 | T1574 | T1573 | arg2Of | IKK,( |
R1394 | T1575 | T1573 | arg3Of | ),( |
R1395 | T1576 | T1561 | arg1Of | phosphorylates,In |
R1396 | T1576 | T1568 | arg1Of | phosphorylates,"," |
R1397 | T1576 | T1578 | arg1Of | phosphorylates,at |
R1398 | T1577 | T1576 | arg2Of | IκB,phosphorylates |
R1399 | T1581 | T1578 | arg2Of | residues,at |
R1400 | T1581 | T1579 | arg1Of | residues,specific |
R1401 | T1581 | T1580 | arg1Of | residues,serine |
R1402 | T1581 | T1582 | arg1Of | residues,that |
R1403 | T1581 | T1583 | arg1Of | residues,target |
R1404 | T1585 | T1583 | arg2Of | protein,target |
R1405 | T1585 | T1584 | arg1Of | protein,the |
R1406 | T1585 | T1586 | arg1Of | protein,to |
R1407 | T1587 | T1588 | arg1Of | ubiquitination,and |
R1408 | T1588 | T1586 | arg2Of | and,to |
R1409 | T1588 | T1591 | arg1Of | and,"," |
R1410 | T1588 | T1592 | arg1Of | and,which |
R1411 | T1588 | T1593 | arg1Of | and,releases |
R1412 | T1590 | T1588 | arg2Of | degradation,and |
R1413 | T1590 | T1589 | arg1Of | degradation,proteasomal |
R1414 | T1597 | T1593 | arg2Of | complex,releases |
R1415 | T1597 | T1594 | arg1Of | complex,the |
R1416 | T1597 | T1595 | arg1Of | complex,functional |
R1417 | T1597 | T1596 | arg1Of | complex,NF-κB |
R1418 | T1597 | T1598 | arg1Of | complex,in |
R1419 | T1600 | T1598 | arg2Of | nucleus,in |
R1420 | T1600 | T1599 | arg1Of | nucleus,the |
bionlp-st-ge-2016-spacy-parsed
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2442 | 0-2 | IN | denotes | In |
T2443 | 3-6 | DT | denotes | the |
T2444 | 7-16 | JJ | denotes | canonical |
T2445 | 17-24 | NN | denotes | pathway |
T2446 | 25-27 | IN | denotes | of |
T2447 | 28-33 | JJ | denotes | NF-κB |
T2448 | 34-44 | NN | denotes | activation |
T2449 | 44-45 | , | denotes | , |
T2450 | 46-49 | DT | denotes | the |
T2451 | 50-59 | VBN | denotes | activated |
T2452 | 60-63 | NNP | denotes | IκB |
T2453 | 64-70 | NN | denotes | kinase |
T2454 | 71-72 | -LRB- | denotes | ( |
T2455 | 72-75 | NNP | denotes | IKK |
T2456 | 75-76 | -RRB- | denotes | ) |
T2457 | 77-91 | VBZ | denotes | phosphorylates |
T2458 | 92-95 | NNP | denotes | IκB |
T2459 | 96-98 | IN | denotes | at |
T2460 | 99-107 | JJ | denotes | specific |
T2461 | 108-114 | NN | denotes | serine |
T2462 | 115-123 | NNS | denotes | residues |
T2463 | 124-128 | WDT | denotes | that |
T2464 | 129-135 | VBP | denotes | target |
T2465 | 136-139 | DT | denotes | the |
T2466 | 140-147 | NN | denotes | protein |
T2467 | 148-150 | TO | denotes | to |
T2468 | 151-165 | NN | denotes | ubiquitination |
T2469 | 166-169 | CC | denotes | and |
T2470 | 170-181 | JJ | denotes | proteasomal |
T2471 | 182-193 | NN | denotes | degradation |
T2472 | 193-194 | , | denotes | , |
T2473 | 195-200 | WDT | denotes | which |
T2474 | 201-209 | VBZ | denotes | releases |
T2475 | 210-213 | DT | denotes | the |
T2476 | 214-224 | JJ | denotes | functional |
T2477 | 225-230 | NN | denotes | NF-κB |
T2478 | 231-238 | NN | denotes | complex |
T2479 | 239-241 | IN | denotes | in |
T2480 | 242-245 | DT | denotes | the |
T2481 | 246-253 | NN | denotes | nucleus |
T2482 | 253-254 | . | denotes | . |
R2129 | T2474 | T2471 | relcl | releases,degradation |
R2130 | T2475 | T2478 | det | the,complex |
R2131 | T2476 | T2478 | amod | functional,complex |
R2133 | T2477 | T2478 | compound | NF-κB,complex |
R2134 | T2478 | T2474 | dobj | complex,releases |
R2136 | T2479 | T2478 | prep | in,complex |
R2137 | T2480 | T2481 | det | the,nucleus |
R2138 | T2481 | T2479 | pobj | nucleus,in |
R2140 | T2482 | T2457 | punct | .,phosphorylates |
R2319 | T2442 | T2457 | prep | In,phosphorylates |
R2323 | T2443 | T2445 | det | the,pathway |
R2327 | T2444 | T2445 | amod | canonical,pathway |
R2331 | T2445 | T2442 | pobj | pathway,In |
R2335 | T2446 | T2445 | prep | of,pathway |
R2339 | T2447 | T2448 | amod | NF-κB,activation |
R2344 | T2448 | T2446 | pobj | activation,of |
R2348 | T2449 | T2457 | punct | ",",phosphorylates |
R2354 | T2450 | T2453 | det | the,kinase |
R2358 | T2451 | T2453 | amod | activated,kinase |
R2362 | T2452 | T2453 | compound | IκB,kinase |
R2365 | T2453 | T2457 | nsubj | kinase,phosphorylates |
R2367 | T2454 | T2455 | punct | (,IKK |
R2371 | T2455 | T2453 | appos | IKK,kinase |
R2375 | T2456 | T2453 | punct | ),kinase |
R2379 | T2457 | T2457 | ROOT | phosphorylates,phosphorylates |
R2383 | T2458 | T2457 | dobj | IκB,phosphorylates |
R2387 | T2459 | T2457 | prep | at,phosphorylates |
R2390 | T2460 | T2462 | amod | specific,residues |
R2391 | T2461 | T2462 | compound | serine,residues |
R2392 | T2462 | T2459 | pobj | residues,at |
R2394 | T2463 | T2464 | nsubj | that,target |
R2398 | T2464 | T2462 | relcl | target,residues |
R2405 | T2465 | T2466 | det | the,protein |
R2410 | T2466 | T2464 | dobj | protein,target |
R2413 | T2467 | T2468 | aux | to,ubiquitination |
R2417 | T2468 | T2464 | advcl | ubiquitination,target |
R2421 | T2469 | T2468 | cc | and,ubiquitination |
R2425 | T2470 | T2471 | amod | proteasomal,degradation |
R2429 | T2471 | T2468 | conj | degradation,ubiquitination |
R2433 | T2472 | T2471 | punct | ",",degradation |
R2437 | T2473 | T2474 | nsubj | which,releases |
GO-BP
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3172 | 28-44 | http://purl.obolibrary.org/obo/GO_0051092 | denotes | NF-κB activation |
T3175 | 72-75 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
T3179 | 140-165 | http://purl.obolibrary.org/obo/GO_0016567 | denotes | protein to ubiquitination |
T3180 | 182-193 | http://purl.obolibrary.org/obo/GO_0009056 | denotes | degradation |
GO-MF
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3234 | 72-75 | http://purl.obolibrary.org/obo/GO_0008384 | denotes | IKK |
GO-CC
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T3207 | 225-238 | http://purl.obolibrary.org/obo/GO_0071159 | denotes | NF-κB complex |
T3209 | 246-253 | http://purl.obolibrary.org/obo/GO_0005634 | denotes | nucleus |
sentences
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T1433 | 0-254 | Sentence | denotes | In the canonical pathway of NF-κB activation, the activated IκB kinase (IKK) phosphorylates IκB at specific serine residues that target the protein to ubiquitination and proteasomal degradation, which releases the functional NF-κB complex in the nucleus. |
T15 | 0-254 | Sentence | denotes | In the canonical pathway of NF-κB activation, the activated IκB kinase (IKK) phosphorylates IκB at specific serine residues that target the protein to ubiquitination and proteasomal degradation, which releases the functional NF-κB complex in the nucleus. |
bionlp-st-ge-2016-reference-tees
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T4204 | 28-33 | Protein | denotes | NF-κB |
T4205 | 60-70 | Protein | denotes | IκB kinase |
T4206 | 72-75 | Protein | denotes | IKK |
T4207 | 92-95 | Protein | denotes | IκB |
T4208 | 225-230 | Protein | denotes | NF-κB |
T4209 | 34-44 | Positive_regulation | denotes | activation |
T4210 | 50-59 | Positive_regulation | denotes | activated |
T4211 | 50-59 | Positive_regulation | denotes | activated |
T4212 | 77-91 | Phosphorylation | denotes | phosphorylates |
T4213 | 77-91 | Phosphorylation | denotes | phosphorylates |
T4214 | 77-91 | Phosphorylation | denotes | phosphorylates |
T4215 | 182-193 | Protein_catabolism | denotes | degradation |
T4216 | 182-193 | Protein_catabolism | denotes | degradation |
T4217 | 201-209 | Positive_regulation | denotes | releases |
T4218 | 201-209 | Positive_regulation | denotes | releases |
T4219 | 231-238 | Binding | denotes | complex |
T4220 | 129-135 | Regulation | denotes | target |
T4221 | 129-135 | Regulation | denotes | target |
R3789 | T4204 | T4209 | themeOf | NF-κB,activation |
R3791 | T4205 | T4210 | themeOf | IκB kinase,activated |
R3792 | T4205 | T4212 | themeOf | IκB kinase,phosphorylates |
R3793 | T4206 | T4211 | themeOf | IKK,activated |
R3794 | T4206 | T4213 | themeOf | IKK,phosphorylates |
R3795 | T4206 | T4215 | themeOf | IKK,degradation |
R3797 | T4207 | T4214 | themeOf | IκB,phosphorylates |
R3798 | T4207 | T4216 | themeOf | IκB,degradation |
R3800 | T4208 | T4219 | themeOf | NF-κB,complex |
R3804 | T4215 | T4217 | themeOf | degradation,releases |
R3805 | T4215 | T4220 | themeOf | degradation,target |
R3807 | T4216 | T4218 | themeOf | degradation,releases |
R3808 | T4216 | T4221 | themeOf | degradation,target |
bionlp-st-ge-2016-uniprot
Id | Subject | Object | Predicate | Lexical cue |
---|---|---|---|---|
T2259 | 60-70 | O15111 | denotes | IκB kinase |
T2260 | 60-70 | Q60680-2 | denotes | IκB kinase |