PMC:3333881 / 1360-5823 JSON TXT

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2_test

Id	Subject	Object	Predicate	Lexical cue
22187158-18927578-77584393	153-154	18927578	denotes	1
22187158-19302050-77584394	528-529	19302050	denotes	2
22187158-12360211-77584395	630-631	12360211	denotes	3
22187158-1829648-77584396	934-935	1829648	denotes	4
22187158-7878466-77584397	983-984	7878466	denotes	5
22187158-7479976-77584398	1075-1076	7479976	denotes	6
22187158-9660950-77584399	1163-1164	9660950	denotes	7
22187158-12628924-77584400	1165-1166	12628924	denotes	8
22187158-12881425-77584401	1185-1186	12881425	denotes	9
22187158-10521409-77584402	1208-1210	10521409	denotes	10
22187158-14963024-77584403	1211-1213	14963024	denotes	11
22187158-11533489-77584404	1391-1393	11533489	denotes	12
22187158-12456660-77584405	1394-1396	12456660	denotes	13
22187158-8096091-77584406	1587-1589	8096091	denotes	20
22187158-8319912-77584406	1587-1589	8319912	denotes	20
22187158-12424381-77584406	1587-1589	12424381	denotes	20
22187158-15499023-77584406	1587-1589	15499023	denotes	20
22187158-15258597-77584406	1587-1589	15258597	denotes	20
22187158-18676814-77584406	1587-1589	18676814	denotes	20
22187158-11533489-77584407	1725-1727	11533489	denotes	12
22187158-12419806-77584408	1728-1730	12419806	denotes	21
22187158-15152190-77584409	1731-1733	15152190	denotes	22
22187158-7853483-77584410	1999-2001	7853483	denotes	25
22187158-11160127-77584410	1999-2001	11160127	denotes	25
22187158-8764027-77584410	1999-2001	8764027	denotes	25
22187158-18947296-77584411	2084-2086	18947296	denotes	26
22187158-19840555-77584412	2087-2089	19840555	denotes	27
22187158-11160730-77584413	2303-2305	11160730	denotes	28
22187158-18806803-77584414	2306-2308	18806803	denotes	29
22187158-11959143-77584415	2542-2544	11959143	denotes	30
22187158-19287489-77584416	2564-2566	19287489	denotes	31
22187158-2478293-77584417	2866-2868	2478293	denotes	32
22187158-8139045-77584418	2903-2905	8139045	denotes	33
22187158-9169458-77584419	2933-2935	9169458	denotes	34
22187158-7690421-77584420	3104-3106	7690421	denotes	35
22187158-8121496-77584421	3116-3118	8121496	denotes	36
22187158-12055184-77584422	3128-3130	12055184	denotes	37
22187158-15710476-77584423	3141-3143	15710476	denotes	38
22187158-7853496-77584424	3162-3164	7853496	denotes	39
22187158-9491887-77584425	3165-3167	9491887	denotes	40
22187158-9811832-77584426	3227-3229	9811832	denotes	43
22187158-9733868-77584426	3227-3229	9733868	denotes	43
22187158-9733796-77584426	3227-3229	9733796	denotes	43
22187158-10397733-77584427	3357-3359	10397733	denotes	44
22187158-8946838-77584428	3381-3383	8946838	denotes	45
22187158-9789057-77584429	3410-3412	9789057	denotes	46
22187158-8113688-77584430	3522-3524	8113688	denotes	47
22187158-8676466-77584431	3647-3649	8676466	denotes	48
22187158-18329615-77584432	3762-3764	18329615	denotes	49
22187158-8096091-77584433	3991-3993	8096091	denotes	15
22187158-12424381-77584434	3994-3996	12424381	denotes	17
22187158-17942396-77584435	4104-4106	17942396	denotes	50
22187158-21664225-77584436	4107-4109	21664225	denotes	51

pmc-enju-pas

Id	Subject	Object	Predicate	Lexical cue
T1454	13-20	JJ	denotes	Nuclear
T1455	21-27	NN	denotes	factor
T1456	28-29	-LRB-	denotes	(
T1457	29-31	NN	denotes	NF
T1458	31-32	-RRB-	denotes	)
T1459	32-35	NN	denotes	-κB
T1460	36-49	NN	denotes	transcription
T1461	50-57	NN	denotes	factors
T1462	58-66	VB	denotes	regulate
T1463	67-70	DT	denotes	the
T1464	71-84	NN	denotes	transcription
T1465	85-87	IN	denotes	of
T1466	88-93	NN	denotes	genes
T1467	94-98	WDT	denotes	that
T1468	99-102	VB	denotes	are
T1469	103-111	VB	denotes	involved
T1470	112-114	IN	denotes	in
T1471	115-118	DT	denotes	the
T1472	119-125	JJ	denotes	immune
T1473	126-129	CC	denotes	and
T1474	130-142	JJ	denotes	inflammatory
T1475	143-151	NN	denotes	response
T1476	152-153	-LRB-	denotes	(
T1477	153-154	CD	denotes	1
T1478	154-155	-RRB-	denotes	)
T1479	157-160	DT	denotes	The
T1480	161-166	NN	denotes	NF-κB
T1481	167-173	NN	denotes	family
T1482	174-182	VB	denotes	includes
T1483	183-191	NN	denotes	RelA/p65
T1484	191-192	-COMMA-	denotes	,
T1485	193-198	NN	denotes	c-Rel
T1486	198-199	-COMMA-	denotes	,
T1487	200-204	NN	denotes	RelB
T1488	204-205	-COMMA-	denotes	,
T1489	206-209	NN	denotes	p50
T1490	210-213	CC	denotes	and
T1491	214-217	NN	denotes	p52
T1492	218-222	WDT	denotes	that
T1493	223-228	VB	denotes	share
T1494	229-230	DT	denotes	a
T1495	231-237	RB	denotes	highly
T1496	238-247	VB	denotes	conserved
T1497	248-257	JJ	denotes	300-amino
T1498	258-262	NN	denotes	acid
T1499	263-266	NN	denotes	Rel
T1500	267-275	NN	denotes	homology
T1501	276-282	NN	denotes	domain
T1502	283-284	-LRB-	denotes	(
T1503	284-287	NN	denotes	RHD
T1504	287-288	-RRB-	denotes	)
T1505	289-292	IN	denotes	for
T1506	293-298	JJ	denotes	homo-
T1507	299-301	CC	denotes	or
T1508	302-321	NN	denotes	hetero-dimerization
T1509	322-325	CC	denotes	and
T1510	326-337	NN	denotes	DNA-binding
T1511	339-342	DT	denotes	The
T1512	343-358	JJ	denotes	transcriptional
T1513	359-367	NN	denotes	activity
T1514	368-370	IN	denotes	of
T1515	371-374	DT	denotes	the
T1516	375-380	NN	denotes	NF-κB
T1517	381-388	NN	denotes	complex
T1518	389-396	VB	denotes	depends
T1519	397-399	IN	denotes	on
T1520	400-405	NN	denotes	dimer
T1521	406-417	NN	denotes	composition
T1522	418-423	IN	denotes	since
T1523	424-434	JJ	denotes	C-terminal
T1524	435-444	JJ	denotes	unrelated
T1525	445-460	JJ	denotes	transcriptional
T1526	461-471	NN	denotes	activation
T1527	472-479	NN	denotes	domains
T1528	480-483	VB	denotes	are
T1529	484-491	JJ	denotes	present
T1530	492-503	RB	denotes	exclusively
T1531	504-506	IN	denotes	in
T1532	507-510	NN	denotes	p65
T1533	510-511	-COMMA-	denotes	,
T1534	512-516	NN	denotes	RelB
T1535	517-520	CC	denotes	and
T1536	521-526	NN	denotes	c-Rel
T1537	527-528	-LRB-	denotes	(
T1538	528-529	CD	denotes	2
T1539	529-530	-RRB-	denotes	)
T1540	532-542	NN	denotes	Inhibitors
T1541	543-545	IN	denotes	of
T1542	546-551	NN	denotes	NF-κB
T1543	552-553	-LRB-	denotes	(
T1544	553-556	NN	denotes	IκB
T1545	556-557	-RRB-	denotes	)
T1546	558-567	VB	denotes	associate
T1547	568-572	IN	denotes	with
T1548	573-576	DT	denotes	the
T1549	577-582	NN	denotes	NF-κB
T1550	583-590	NN	denotes	complex
T1551	591-594	CC	denotes	and
T1552	595-604	VB	denotes	interfere
T1553	605-609	IN	denotes	with
T1554	610-613	PRP-DOLLAR-	denotes	its
T1555	614-621	NN	denotes	binding
T1556	622-624	TO	denotes	to
T1557	625-628	NN	denotes	DNA
T1558	629-630	-LRB-	denotes	(
T1559	630-631	CD	denotes	3
T1560	631-632	-RRB-	denotes	)
T1561	634-636	IN	denotes	In
T1562	637-640	DT	denotes	the
T1563	641-650	JJ	denotes	canonical
T1564	651-658	NN	denotes	pathway
T1565	659-661	IN	denotes	of
T1566	662-667	NN	denotes	NF-κB
T1567	668-678	NN	denotes	activation
T1568	678-679	-COMMA-	denotes	,
T1569	680-683	DT	denotes	the
T1570	684-693	VB	denotes	activated
T1571	694-697	NN	denotes	IκB
T1572	698-704	NN	denotes	kinase
T1573	705-706	-LRB-	denotes	(
T1574	706-709	NN	denotes	IKK
T1575	709-710	-RRB-	denotes	)
T1576	711-725	VB	denotes	phosphorylates
T1577	726-729	NN	denotes	IκB
T1578	730-732	IN	denotes	at
T1579	733-741	JJ	denotes	specific
T1580	742-748	NN	denotes	serine
T1581	749-757	NN	denotes	residues
T1582	758-762	WDT	denotes	that
T1583	763-769	VB	denotes	target
T1584	770-773	DT	denotes	the
T1585	774-781	NN	denotes	protein
T1586	782-784	TO	denotes	to
T1587	785-799	NN	denotes	ubiquitination
T1588	800-803	CC	denotes	and
T1589	804-815	JJ	denotes	proteasomal
T1590	816-827	NN	denotes	degradation
T1591	827-828	-COMMA-	denotes	,
T1592	829-834	WDT	denotes	which
T1593	835-843	VB	denotes	releases
T1594	844-847	DT	denotes	the
T1595	848-858	JJ	denotes	functional
T1596	859-864	NN	denotes	NF-κB
T1597	865-872	NN	denotes	complex
T1598	873-875	IN	denotes	in
T1599	876-879	DT	denotes	the
T1600	880-887	NN	denotes	nucleus
T1601	889-894	NN	denotes	IκB-α
T1602	894-895	-COMMA-	denotes	,
T1603	896-899	DT	denotes	the
T1604	900-904	RB	denotes	most
T1605	905-913	JJ	denotes	abundant
T1606	914-923	NN	denotes	inhibitor
T1607	924-926	IN	denotes	of
T1608	927-932	NN	denotes	NF-κB
T1609	933-934	-LRB-	denotes	(
T1610	934-935	CD	denotes	4
T1611	935-936	-RRB-	denotes	)
T1612	936-937	-COMMA-	denotes	,
T1613	938-940	VB	denotes	is
T1614	941-955	VB	denotes	phosphorylated
T1615	956-958	IN	denotes	by
T1616	959-962	NN	denotes	IKK
T1617	963-965	IN	denotes	at
T1618	966-971	NN	denotes	Ser32
T1619	972-975	CC	denotes	and
T1620	976-981	NN	denotes	Ser36
T1621	982-983	-LRB-	denotes	(
T1622	983-984	CD	denotes	5
T1623	984-985	-RRB-	denotes	)
T1624	985-986	-COMMA-	denotes	,
T1625	987-990	CC	denotes	and
T1626	991-1003	RB	denotes	subsequently
T1627	1004-1017	VB	denotes	ubiquitylated
T1628	1018-1020	IN	denotes	at
T1629	1021-1026	NN	denotes	Lys21
T1630	1027-1030	CC	denotes	and
T1631	1031-1036	NN	denotes	Lys22
T1632	1037-1039	TO	denotes	to
T1633	1040-1042	VB	denotes	be
T1634	1043-1051	VB	denotes	degraded
T1635	1052-1054	IN	denotes	by
T1636	1055-1058	DT	denotes	the
T1637	1059-1062	NN	denotes	26S
T1638	1063-1073	NN	denotes	proteasome
T1639	1074-1075	-LRB-	denotes	(
T1640	1075-1076	CD	denotes	6
T1641	1076-1077	-RRB-	denotes	)
T1642	1079-1082	DT	denotes	The
T1643	1083-1088	NN	denotes	NF-κB
T1644	1089-1097	NN	denotes	activity
T1645	1098-1100	VB	denotes	is
T1646	1101-1109	VB	denotes	enhanced
T1647	1110-1112	IN	denotes	by
T1648	1113-1128	NN	denotes	phosphorylation
T1649	1129-1131	IN	denotes	of
T1650	1132-1135	NN	denotes	p65
T1651	1136-1138	IN	denotes	at
T1652	1139-1145	NN	denotes	Ser276
T1653	1146-1148	IN	denotes	by
T1654	1149-1152	NN	denotes	PKA
T1655	1153-1156	CC	denotes	and
T1656	1157-1161	NN	denotes	MSK1
T1657	1162-1163	-LRB-	denotes	(
T1658	1163-1166	NN	denotes	7,8
T1659	1166-1167	-RRB-	denotes	)
T1660	1167-1168	-COMMA-	denotes	,
T1661	1169-1175	NN	denotes	Ser311
T1662	1176-1178	IN	denotes	by
T1663	1179-1183	NN	denotes	PKCζ
T1664	1184-1185	-LRB-	denotes	(
T1665	1185-1186	CD	denotes	9
T1666	1186-1187	-RRB-	denotes	)
T1667	1188-1191	CC	denotes	and
T1668	1192-1198	NN	denotes	Ser536
T1669	1199-1201	IN	denotes	by
T1670	1202-1206	NN	denotes	IKKα
T1671	1207-1208	-LRB-	denotes	(
T1672	1208-1213	CD	denotes	10,11
T1673	1213-1214	-RRB-	denotes	)
T1674	1216-1227	NN	denotes	Acetylation
T1675	1228-1230	IN	denotes	of
T1676	1231-1234	NN	denotes	p65
T1677	1235-1237	IN	denotes	at
T1678	1238-1244	NN	denotes	Lys218
T1679	1245-1248	CC	denotes	and
T1680	1249-1255	NN	denotes	Lys221
T1681	1256-1265	VB	denotes	increases
T1682	1266-1269	DT	denotes	the
T1683	1270-1273	NN	denotes	DNA
T1684	1274-1281	NN	denotes	binding
T1685	1282-1285	CC	denotes	and
T1686	1286-1293	VB	denotes	impairs
T1687	1294-1297	DT	denotes	the
T1688	1298-1309	NN	denotes	association
T1689	1310-1314	IN	denotes	with
T1690	1315-1320	NN	denotes	IκB-α
T1691	1320-1321	-COMMA-	denotes	,
T1692	1322-1325	CC	denotes	and
T1693	1326-1337	NN	denotes	acetylation
T1694	1338-1340	IN	denotes	at
T1695	1341-1347	NN	denotes	Lys310
T1696	1348-1356	VB	denotes	enhances
T1697	1357-1360	DT	denotes	the
T1698	1361-1364	NN	denotes	p65
T1699	1365-1380	JJ	denotes	transcriptional
T1700	1381-1389	NN	denotes	activity
T1701	1390-1391	-LRB-	denotes	(
T1702	1391-1396	CD	denotes	12,13
T1703	1396-1397	-RRB-	denotes	)
T1704	1399-1414	NN	denotes	Post-activation
T1705	1415-1419	VB	denotes	turn
T1706	1420-1423	RP	denotes	off
T1707	1424-1426	IN	denotes	of
T1708	1427-1432	NN	denotes	NF-κB
T1709	1433-1435	VB	denotes	is
T1710	1436-1445	VB	denotes	regulated
T1711	1446-1448	IN	denotes	by
T1712	1449-1457	JJ	denotes	negative
T1713	1458-1466	NN	denotes	feedback
T1714	1467-1471	NN	denotes	loop
T1715	1472-1479	IN	denotes	through
T1716	1480-1490	NN	denotes	inhibitors
T1717	1491-1496	IN	denotes	under
T1718	1497-1500	DT	denotes	the
T1719	1501-1516	JJ	denotes	transcriptional
T1720	1517-1524	NN	denotes	control
T1721	1525-1527	IN	denotes	of
T1722	1528-1533	NN	denotes	NF-κB
T1723	1533-1534	-COMMA-	denotes	,
T1724	1535-1539	JJ	denotes	such
T1725	1540-1542	IN	denotes	as
T1726	1543-1548	JJ	denotes	IκB-α
T1727	1549-1552	CC	denotes	and
T1728	1553-1570	JJ	denotes	ubiquitin-editing
T1729	1571-1578	NN	denotes	protein
T1730	1579-1582	NN	denotes	A20
T1731	1583-1584	-LRB-	denotes	(
T1732	1584-1589	CD	denotes	14–20
T1733	1589-1590	-RRB-	denotes	)
T1734	1592-1605	NN	denotes	Deacetylation
T1735	1606-1608	IN	denotes	of
T1736	1609-1612	NN	denotes	p65
T1737	1613-1615	IN	denotes	by
T1738	1616-1623	NN	denotes	histone
T1739	1624-1637	NN	denotes	deacetylase-3
T1740	1638-1640	CC	denotes	or
T1741	1641-1646	NN	denotes	SIRT1
T1742	1646-1647	-COMMA-	denotes	,
T1743	1648-1650	CC	denotes	or
T1744	1651-1662	NN	denotes	acetylation
T1745	1663-1665	IN	denotes	of
T1746	1666-1669	NN	denotes	p65
T1747	1670-1672	IN	denotes	at
T1748	1673-1679	NN	denotes	Lys122
T1749	1680-1683	CC	denotes	and
T1750	1684-1690	NN	denotes	Lys123
T1751	1691-1704	VB	denotes	down-regulate
T1752	1705-1708	DT	denotes	the
T1753	1709-1714	NN	denotes	NF-κB
T1754	1715-1723	NN	denotes	activity
T1755	1724-1725	-LRB-	denotes	(
T1756	1725-1733	CD	denotes	12,21,22
T1757	1733-1734	-RRB-	denotes	)
T1758	1736-1746	JJ	denotes	Persistent
T1759	1747-1757	NN	denotes	activation
T1760	1758-1760	IN	denotes	of
T1761	1761-1766	NN	denotes	NF-κB
T1762	1767-1773	VB	denotes	occurs
T1763	1774-1776	IN	denotes	in
T1764	1777-1782	JJ	denotes	human
T1765	1783-1799	NN	denotes	immunodeficiency
T1766	1800-1807	NN	denotes	virus-1
T1767	1808-1809	-LRB-	denotes	(
T1768	1809-1814	NN	denotes	HIV-1
T1769	1814-1815	-RRB-	denotes	)
T1770	1815-1824	JJ	denotes	-infected
T1771	1825-1834	NN	denotes	monocytes
T1772	1834-1835	-COMMA-	denotes	,
T1773	1836-1847	NN	denotes	macrophages
T1774	1848-1851	CC	denotes	and
T1775	1852-1861	NN	denotes	microglia
T1776	1861-1862	-COMMA-	denotes	,
T1777	1863-1866	CC	denotes	and
T1778	1867-1875	VB	denotes	enhances
T1779	1876-1879	DT	denotes	the
T1780	1880-1890	NN	denotes	expression
T1781	1891-1893	IN	denotes	of
T1782	1894-1910	JJ	denotes	NF-κB-responsive
T1783	1911-1916	NN	denotes	genes
T1784	1916-1917	-COMMA-	denotes	,
T1785	1918-1927	VB	denotes	including
T1786	1928-1944	JJ	denotes	pro-inflammatory
T1787	1945-1954	NN	denotes	cytokines
T1788	1954-1955	-COMMA-	denotes	,
T1789	1956-1960	NN	denotes	cell
T1790	1961-1969	NN	denotes	adhesion
T1791	1970-1979	NN	denotes	molecules
T1792	1980-1983	CC	denotes	and
T1793	1984-1994	NN	denotes	chemokines
T1794	1995-1996	-LRB-	denotes	(
T1795	1996-2001	CD	denotes	23–25
T1796	2001-2002	-RRB-	denotes	)
T1797	2004-2011	JJ	denotes	Chronic
T1798	2012-2024	NN	denotes	inflammation
T1799	2025-2027	VB	denotes	is
T1800	2028-2029	DT	denotes	a
T1801	2030-2035	JJ	denotes	major
T1802	2036-2041	NN	denotes	cause
T1803	2042-2044	IN	denotes	of
T1804	2045-2051	JJ	denotes	immune
T1805	2052-2055	CC	denotes	and
T1806	2056-2062	NN	denotes	neuron
T1807	2063-2074	NN	denotes	dysfunction
T1808	2075-2077	IN	denotes	in
T1809	2078-2082	NN	denotes	AIDS
T1810	2083-2084	-LRB-	denotes	(
T1811	2084-2089	CD	denotes	26,27
T1812	2089-2090	-RRB-	denotes	)
T1813	2092-2104	RB	denotes	Consistently
T1814	2104-2105	-COMMA-	denotes	,
T1815	2106-2115	JJ	denotes	non-human
T1816	2116-2123	JJ	denotes	primate
T1817	2124-2129	NN	denotes	hosts
T1818	2130-2133	IN	denotes	for
T1819	2134-2140	JJ	denotes	simian
T1820	2141-2157	NN	denotes	immunodeficiency
T1821	2158-2163	NN	denotes	virus
T1822	2163-2164	-COMMA-	denotes	,
T1823	2165-2169	JJ	denotes	such
T1824	2170-2172	IN	denotes	as
T1825	2173-2180	JJ	denotes	African
T1826	2181-2186	JJ	denotes	green
T1827	2187-2194	NN	denotes	monkeys
T1828	2195-2198	CC	denotes	and
T1829	2199-2204	JJ	denotes	sooty
T1830	2205-2213	NN	denotes	mangabey
T1831	2213-2214	-COMMA-	denotes	,
T1832	2215-2219	VB	denotes	lack
T1833	2220-2228	JJ	denotes	aberrant
T1834	2229-2235	JJ	denotes	immune
T1835	2236-2246	NN	denotes	activation
T1836	2247-2250	CC	denotes	and
T1837	2251-2253	VB	denotes	do
T1838	2254-2257	RB	denotes	not
T1839	2258-2265	VB	denotes	develop
T1840	2266-2270	NN	denotes	AIDS
T1841	2271-2278	IN	denotes	despite
T1842	2279-2283	JJ	denotes	high
T1843	2284-2289	NN	denotes	virus
T1844	2290-2301	NN	denotes	replication
T1845	2302-2303	-LRB-	denotes	(
T1846	2303-2308	CD	denotes	28,29
T1847	2308-2309	-RRB-	denotes	)
T1848	2311-2315	RB	denotes	Thus
T1849	2315-2316	-COMMA-	denotes	,
T1850	2317-2330	VB	denotes	understanding
T1851	2331-2334	DT	denotes	the
T1852	2335-2345	NN	denotes	mechanisms
T1853	2346-2348	IN	denotes	of
T1854	2349-2354	NN	denotes	NF-κB
T1855	2355-2367	NN	denotes	deregulation
T1856	2368-2370	IN	denotes	by
T1857	2371-2376	NN	denotes	HIV-1
T1858	2377-2380	MD	denotes	may
T1859	2381-2388	VB	denotes	provide
T1860	2389-2396	JJ	denotes	further
T1861	2397-2405	NN	denotes	insights
T1862	2406-2410	IN	denotes	into
T1863	2411-2415	NN	denotes	AIDS
T1864	2416-2428	NN	denotes	pathogenesis
T1865	2430-2432	IN	denotes	In
T1866	2433-2438	NN	denotes	HIV-1
T1867	2439-2444	NN	denotes	entry
T1868	2444-2445	-COMMA-	denotes	,
T1869	2446-2449	DT	denotes	the
T1870	2450-2457	NN	denotes	binding
T1871	2458-2460	IN	denotes	of
T1872	2461-2464	DT	denotes	the
T1873	2465-2470	NN	denotes	gp120
T1874	2471-2476	JJ	denotes	viral
T1875	2477-2485	NN	denotes	envelope
T1876	2486-2488	TO	denotes	to
T1877	2489-2492	NN	denotes	CD4
T1878	2493-2500	VB	denotes	induces
T1879	2501-2504	DT	denotes	the
T1880	2505-2510	NN	denotes	NF-κB
T1881	2511-2519	NN	denotes	activity
T1882	2520-2522	IN	denotes	by
T1883	2523-2533	NN	denotes	activation
T1884	2534-2536	IN	denotes	of
T1885	2537-2540	NN	denotes	IKK
T1886	2541-2542	-LRB-	denotes	(
T1887	2542-2544	CD	denotes	30
T1888	2544-2545	-RRB-	denotes	)
T1889	2546-2549	CC	denotes	and
T1890	2550-2560	NN	denotes	procaspase
T1891	2561-2562	CD	denotes	8
T1892	2563-2564	-LRB-	denotes	(
T1893	2564-2566	CD	denotes	31
T1894	2566-2567	-RRB-	denotes	)
T1895	2569-2578	VB	denotes	Following
T1896	2579-2584	JJ	denotes	viral
T1897	2585-2596	NN	denotes	integration
T1898	2596-2597	-COMMA-	denotes	,
T1899	2598-2601	DT	denotes	the
T1900	2602-2607	JJ	denotes	early
T1901	2608-2615	VB	denotes	encoded
T1902	2616-2621	NN	denotes	HIV-1
T1903	2622-2625	NN	denotes	Tat
T1904	2626-2633	NN	denotes	protein
T1905	2634-2643	VB	denotes	interacts
T1906	2644-2648	IN	denotes	with
T1907	2649-2652	DT	denotes	the
T1908	2653-2658	NN	denotes	HIV-1
T1909	2659-2662	NN	denotes	RNA
T1910	2663-2666	CC	denotes	and
T1911	2667-2671	NN	denotes	host
T1912	2672-2676	NN	denotes	cell
T1913	2677-2684	NN	denotes	factors
T1914	2685-2687	TO	denotes	to
T1915	2688-2695	VB	denotes	sustain
T1916	2696-2699	DT	denotes	the
T1917	2700-2705	JJ	denotes	viral
T1918	2706-2717	NN	denotes	replication
T1919	2719-2722	NN	denotes	Tat
T1920	2723-2728	VB	denotes	binds
T1921	2729-2731	TO	denotes	to
T1922	2732-2735	NN	denotes	RNA
T1923	2736-2745	JJ	denotes	stem-loop
T1924	2746-2756	NN	denotes	structures
T1925	2757-2766	VB	denotes	generated
T1926	2767-2769	IN	denotes	by
T1927	2770-2773	DT	denotes	the
T1928	2774-2776	NN	denotes	5′
T1929	2777-2780	NN	denotes	end
T1930	2781-2783	IN	denotes	of
T1931	2784-2790	NN	denotes	target
T1932	2791-2802	NN	denotes	transcripts
T1933	2802-2803	-COMMA-	denotes	,
T1934	2804-2813	VB	denotes	including
T1935	2814-2817	DT	denotes	the
T1936	2818-2823	NN	denotes	HIV-1
T1937	2824-2850	JJ	denotes	transactivation-responsive
T1938	2851-2858	NN	denotes	element
T1939	2859-2860	-LRB-	denotes	(
T1940	2860-2863	NN	denotes	TAR
T1941	2863-2864	-RRB-	denotes	)
T1942	2865-2866	-LRB-	denotes	(
T1943	2866-2868	CD	denotes	32
T1944	2868-2869	-RRB-	denotes	)
T1945	2869-2870	-COMMA-	denotes	,
T1946	2871-2876	NN	denotes	tumor
T1947	2877-2885	NN	denotes	necrosis
T1948	2886-2892	NN	denotes	factor
T1949	2893-2894	NN	denotes	β
T1950	2895-2896	-LRB-	denotes	(
T1951	2896-2900	NN	denotes	TNFβ
T1952	2900-2901	-RRB-	denotes	)
T1953	2902-2903	-LRB-	denotes	(
T1954	2903-2905	CD	denotes	33
T1955	2905-2906	-RRB-	denotes	)
T1956	2907-2910	CC	denotes	and
T1957	2911-2924	NN	denotes	interleukin-6
T1958	2925-2926	-LRB-	denotes	(
T1959	2926-2930	NN	denotes	IL-6
T1960	2930-2931	-RRB-	denotes	)
T1961	2932-2933	-LRB-	denotes	(
T1962	2933-2935	CD	denotes	34
T1963	2935-2936	-RRB-	denotes	)
T1964	2937-2939	TO	denotes	to
T1965	2940-2948	VB	denotes	activate
T1966	2949-2953	NN	denotes	gene
T1967	2954-2967	NN	denotes	transcription
T1968	2969-2975	RB	denotes	Indeed
T1969	2975-2976	-COMMA-	denotes	,
T1970	2977-2980	NN	denotes	Tat
T1971	2981-2989	VB	denotes	promotes
T1972	2990-2993	DT	denotes	the
T1973	2994-3009	JJ	denotes	transcriptional
T1974	3010-3020	NN	denotes	initiation
T1975	3021-3024	CC	denotes	and
T1976	3025-3035	NN	denotes	elongation
T1977	3036-3038	IN	denotes	by
T1978	3039-3050	VB	denotes	interacting
T1979	3051-3055	IN	denotes	with
T1980	3056-3067	VB	denotes	transacting
T1981	3068-3075	NN	denotes	factors
T1982	3076-3079	CC	denotes	and
T1983	3080-3089	NN	denotes	cofactors
T1984	3089-3090	-COMMA-	denotes	,
T1985	3091-3095	JJ	denotes	such
T1986	3096-3098	IN	denotes	as
T1987	3099-3102	NN	denotes	Sp1
T1988	3103-3104	-LRB-	denotes	(
T1989	3104-3106	CD	denotes	35
T1990	3106-3107	-RRB-	denotes	)
T1991	3107-3108	-COMMA-	denotes	,
T1992	3109-3114	NN	denotes	TFIID
T1993	3115-3116	-LRB-	denotes	(
T1994	3116-3118	CD	denotes	36
T1995	3118-3119	-RRB-	denotes	)
T1996	3119-3120	-COMMA-	denotes	,
T1997	3121-3126	NN	denotes	E2F-4
T1998	3127-3128	-LRB-	denotes	(
T1999	3128-3130	CD	denotes	37
T2000	3130-3131	-RRB-	denotes	)
T2001	3131-3132	-COMMA-	denotes	,
T2002	3133-3139	NN	denotes	C/EBPβ
T2003	3140-3141	-LRB-	denotes	(
T2004	3141-3143	CD	denotes	38
T2005	3143-3144	-RRB-	denotes	)
T2006	3144-3145	-COMMA-	denotes	,
T2007	3146-3152	NN	denotes	cyclin
T2008	3153-3160	NN	denotes	T1/CDK9
T2009	3161-3162	-LRB-	denotes	(
T2010	3162-3167	CD	denotes	39,40
T2011	3167-3168	-RRB-	denotes	)
T2012	3169-3172	CC	denotes	and
T2013	3173-3176	DT	denotes	the
T2014	3177-3184	NN	denotes	histone
T2015	3185-3203	NN	denotes	acetyltransferases
T2016	3204-3212	NN	denotes	p300/CBP
T2017	3213-3216	CC	denotes	and
T2018	3217-3222	NN	denotes	P/CAF
T2019	3223-3224	-LRB-	denotes	(
T2020	3224-3229	CD	denotes	41–43
T2021	3229-3230	-RRB-	denotes	)
T2022	3232-3236	WRB	denotes	When
T2023	3237-3245	VB	denotes	released
T2024	3246-3250	IN	denotes	from
T2025	3251-3265	JJ	denotes	HIV-1-infected
T2026	3266-3271	NN	denotes	cells
T2027	3271-3272	-COMMA-	denotes	,
T2028	3273-3276	NN	denotes	Tat
T2029	3277-3288	VB	denotes	deregulates
T2030	3289-3292	DT	denotes	the
T2031	3293-3297	NN	denotes	cell
T2032	3298-3307	NN	denotes	signaling
T2033	3308-3310	IN	denotes	by
T2034	3311-3318	VB	denotes	binding
T2035	3319-3321	TO	denotes	to
T2036	3322-3326	NN	denotes	cell
T2037	3327-3336	NN	denotes	receptors
T2038	3336-3337	-COMMA-	denotes	,
T2039	3338-3342	JJ	denotes	such
T2040	3343-3345	IN	denotes	as
T2041	3346-3355	NN	denotes	integrins
T2042	3356-3357	-LRB-	denotes	(
T2043	3357-3359	CD	denotes	44
T2044	3359-3360	-RRB-	denotes	)
T2045	3360-3361	-COMMA-	denotes	,
T2046	3362-3370	NN	denotes	Flk1/KDR
T2047	3371-3379	NN	denotes	receptor
T2048	3380-3381	-LRB-	denotes	(
T2049	3381-3383	CD	denotes	45
T2050	3383-3384	-RRB-	denotes	)
T2051	3385-3388	CC	denotes	and
T2052	3389-3398	NN	denotes	chemokine
T2053	3399-3408	NN	denotes	receptors
T2054	3409-3410	-LRB-	denotes	(
T2055	3410-3412	CD	denotes	46
T2056	3412-3413	-RRB-	denotes	)
T2057	3415-3417	PRP	denotes	We
T2058	3418-3423	RB	denotes	first
T2059	3424-3432	VB	denotes	reported
T2060	3433-3437	IN	denotes	that
T2061	3438-3443	NN	denotes	NF-κB
T2062	3444-3447	VB	denotes	was
T2063	3448-3462	RB	denotes	constitutively
T2064	3463-3469	JJ	denotes	active
T2065	3470-3472	IN	denotes	in
T2066	3473-3479	NN	denotes	Jurkat
T2067	3480-3485	NN	denotes	cells
T2068	3486-3490	WDT	denotes	that
T2069	3491-3497	RB	denotes	stably
T2070	3498-3507	VB	denotes	expressed
T2071	3508-3511	DT	denotes	the
T2072	3512-3515	NN	denotes	Tat
T2073	3516-3520	NN	denotes	gene
T2074	3521-3522	-LRB-	denotes	(
T2075	3522-3524	CD	denotes	47
T2076	3524-3525	-RRB-	denotes	)
T2077	3527-3536	VB	denotes	Following
T2078	3537-3541	NN	denotes	gene
T2079	3542-3554	NN	denotes	transfection
T2080	3555-3557	CC	denotes	or
T2081	3558-3565	NN	denotes	protein
T2082	3566-3578	NN	denotes	transduction
T2083	3578-3579	-COMMA-	denotes	,
T2084	3580-3583	NN	denotes	Tat
T2085	3584-3591	VB	denotes	induced
T2086	3592-3595	DT	denotes	the
T2087	3596-3599	NN	denotes	IKK
T2088	3600-3608	NN	denotes	activity
T2089	3609-3612	CC	denotes	and
T2090	3613-3624	JJ	denotes	proteasomal
T2091	3625-3636	NN	denotes	degradation
T2092	3637-3639	IN	denotes	of
T2093	3640-3645	NN	denotes	IκB-α
T2094	3646-3647	-LRB-	denotes	(
T2095	3647-3649	CD	denotes	48
T2096	3649-3650	-RRB-	denotes	)
T2097	3650-3651	-COMMA-	denotes	,
T2098	3652-3655	CC	denotes	and
T2099	3656-3665	VB	denotes	increased
T2100	3666-3669	DT	denotes	the
T2101	3670-3673	NN	denotes	p65
T2102	3674-3689	JJ	denotes	transcriptional
T2103	3690-3698	NN	denotes	activity
T2104	3699-3701	IN	denotes	by
T2105	3702-3712	VB	denotes	inhibiting
T2106	3713-3716	DT	denotes	the
T2107	3717-3732	JJ	denotes	SIRT-1-mediated
T2108	3733-3746	NN	denotes	deacetylation
T2109	3747-3749	IN	denotes	of
T2110	3750-3753	NN	denotes	p65
T2111	3754-3760	NN	denotes	Lys310
T2112	3761-3762	-LRB-	denotes	(
T2113	3762-3764	CD	denotes	49
T2114	3764-3765	-RRB-	denotes	)
T2115	3767-3772	DT	denotes	These
T2116	3773-3781	NN	denotes	findings
T2117	3782-3791	VB	denotes	suggested
T2118	3792-3796	IN	denotes	that
T2119	3797-3800	NN	denotes	Tat
T2120	3801-3810	VB	denotes	modulates
T2121	3811-3818	JJ	denotes	crucial
T2122	3819-3826	NN	denotes	enzymes
T2123	3827-3835	VB	denotes	involved
T2124	3836-3838	IN	denotes	in
T2125	3839-3844	NN	denotes	NF-κB
T2126	3845-3854	NN	denotes	signaling
T2127	3854-3855	-COLON-	denotes	;
T2128	3856-3863	RB	denotes	however
T2129	3863-3864	-COMMA-	denotes	,
T2130	3865-3867	PRP	denotes	it
T2131	3868-3871	VB	denotes	was
T2132	3872-3879	JJ	denotes	unclear
T2133	3880-3883	WRB	denotes	how
T2134	3884-3887	NN	denotes	Tat
T2135	3888-3893	MD	denotes	could
T2136	3894-3901	VB	denotes	subvert
T2137	3902-3905	DT	denotes	the
T2138	3906-3914	JJ	denotes	negative
T2139	3915-3923	NN	denotes	feedback
T2140	3924-3926	IN	denotes	of
T2141	3927-3932	NN	denotes	NF-κB
T2142	3932-3933	-COMMA-	denotes	,
T2143	3934-3939	WDT	denotes	which
T2144	3940-3942	VB	denotes	is
T2145	3943-3949	RB	denotes	mainly
T2146	3950-3959	JJ	denotes	dependent
T2147	3960-3962	IN	denotes	on
T2148	3963-3965	FW	denotes	de
T2149	3966-3970	FW	denotes	novo
T2150	3971-3980	NN	denotes	synthesis
T2151	3981-3983	IN	denotes	of
T2152	3984-3989	NN	denotes	IκB-α
T2153	3990-3991	-LRB-	denotes	(
T2154	3991-3996	CD	denotes	15,17
T2155	3996-3997	-RRB-	denotes	)
T2156	3999-4001	PRP	denotes	We
T2157	4002-4012	RB	denotes	previously
T2158	4013-4018	VB	denotes	found
T2159	4019-4023	IN	denotes	that
T2160	4024-4029	NN	denotes	IκB-α
T2161	4030-4035	VB	denotes	binds
T2162	4036-4038	TO	denotes	to
T2163	4039-4042	NN	denotes	Tat
T2164	4043-4046	CC	denotes	and
T2165	4047-4055	VB	denotes	promotes
T2166	4056-4059	DT	denotes	the
T2167	4060-4067	JJ	denotes	nuclear
T2168	4068-4074	NN	denotes	export
T2169	4075-4077	IN	denotes	of
T2170	4078-4081	DT	denotes	the
T2171	4082-4087	JJ	denotes	viral
T2172	4088-4102	NN	denotes	transactivator
T2173	4103-4104	-LRB-	denotes	(
T2174	4104-4109	CD	denotes	50,51
T2175	4109-4110	-RRB-	denotes	)
T2176	4112-4114	IN	denotes	In
T2177	4115-4119	DT	denotes	this
T2178	4120-4125	NN	denotes	study
T2179	4125-4126	-COMMA-	denotes	,
T2180	4127-4129	PRP	denotes	we
T2181	4130-4136	VB	denotes	report
T2182	4137-4141	IN	denotes	that
T2183	4142-4145	NN	denotes	Tat
T2184	4146-4157	VB	denotes	counteracts
T2185	4158-4161	DT	denotes	the
T2186	4162-4177	JJ	denotes	post-activation
T2187	4178-4182	NN	denotes	turn
T2188	4183-4186	RP	denotes	off
T2189	4187-4189	IN	denotes	of
T2190	4190-4195	NN	denotes	NF-κB
T2191	4196-4203	IN	denotes	through
T2192	4204-4210	JJ	denotes	direct
T2193	4211-4222	NN	denotes	interaction
T2194	4223-4227	IN	denotes	with
T2195	4228-4233	NN	denotes	IκB-α
T2196	4234-4237	CC	denotes	and
T2197	4238-4241	NN	denotes	p65
T2198	4241-4242	-COMMA-	denotes	,
T2199	4243-4248	WDT	denotes	which
T2200	4249-4257	VB	denotes	enhances
T2201	4258-4261	DT	denotes	the
T2202	4262-4265	NN	denotes	DNA
T2203	4266-4273	NN	denotes	binding
T2204	4274-4277	CC	denotes	and
T2205	4278-4293	JJ	denotes	transcriptional
T2206	4294-4302	NN	denotes	activity
T2207	4303-4305	IN	denotes	of
T2208	4306-4309	DT	denotes	the
T2209	4310-4315	NN	denotes	NF-κB
T2210	4316-4323	NN	denotes	complex
T2211	4325-4328	DT	denotes	The
T2212	4329-4332	JJ	denotes	new
T2213	4333-4342	NN	denotes	mechanism
T2214	4343-4345	IN	denotes	of
T2215	4346-4351	NN	denotes	NF-κB
T2216	4352-4364	NN	denotes	deregulation
T2217	4365-4369	RB	denotes	here
T2218	4370-4379	VB	denotes	described
T2219	4380-4383	MD	denotes	may
T2220	4384-4391	VB	denotes	provide
T2221	4392-4399	JJ	denotes	further
T2222	4400-4408	NN	denotes	insights
T2223	4409-4413	IN	denotes	into
T2224	4414-4417	DT	denotes	the
T2225	4418-4425	JJ	denotes	chronic
T2226	4426-4432	JJ	denotes	immune
T2227	4433-4443	NN	denotes	activation
T2228	4444-4446	IN	denotes	of
T2229	4447-4452	NN	denotes	HIV-1
T2230	4453-4462	NN	denotes	infection
R1275	T1457	T1456	arg2Of	NF,(
R1276	T1458	T1456	arg3Of	),(
R1279	T1461	T1454	arg1Of	factors,Nuclear
R1280	T1461	T1455	arg1Of	factors,factor
R1281	T1461	T1456	arg1Of	factors,(
R1282	T1461	T1459	arg1Of	factors,-κB
R1285	T1464	T1465	arg1Of	transcription,of
R1286	T1466	T1465	arg2Of	genes,of
R1287	T1466	T1467	arg1Of	genes,that
R1288	T1466	T1468	arg1Of	genes,are
R1289	T1466	T1469	arg2Of	genes,involved
R1290	T1469	T1468	arg2Of	involved,are
R1291	T1469	T1470	arg1Of	involved,in
R1292	T1472	T1473	arg1Of	immune,and
R1293	T1474	T1473	arg2Of	inflammatory,and
R1294	T1475	T1470	arg2Of	response,in
R1295	T1475	T1471	arg1Of	response,the
R1296	T1475	T1472	arg1Of	response,immune
R1297	T1475	T1474	arg1Of	response,inflammatory
R1298	T1475	T1476	arg1Of	response,(
R1299	T1477	T1476	arg2Of	1,(
R1300	T1478	T1476	arg3Of	),(
R1301	T1481	T1479	arg1Of	family,The
R1302	T1481	T1480	arg1Of	family,NF-κB
R1303	T1481	T1482	arg1Of	family,includes
R1304	T1483	T1484	arg1Of	RelA/p65,","
R1305	T1484	T1486	arg1Of	",",","
R1306	T1485	T1484	arg2Of	c-Rel,","
R1307	T1486	T1488	arg1Of	",",","
R1308	T1487	T1486	arg2Of	RelB,","
R1309	T1488	T1482	arg2Of	",",includes
R1310	T1488	T1492	arg1Of	",",that
R1311	T1488	T1493	arg1Of	",",share
R1312	T1489	T1490	arg1Of	p50,and
R1313	T1490	T1488	arg2Of	and,","
R1314	T1491	T1490	arg2Of	p52,and
R1315	T1493	T1505	arg1Of	share,for
R1316	T1496	T1495	arg1Of	conserved,highly
R1317	T1501	T1493	arg2Of	domain,share
R1318	T1501	T1494	arg1Of	domain,a
R1319	T1501	T1496	arg1Of	domain,conserved
R1320	T1501	T1497	arg1Of	domain,300-amino
R1321	T1501	T1498	arg1Of	domain,acid
R1322	T1501	T1499	arg1Of	domain,Rel
R1323	T1501	T1500	arg1Of	domain,homology
R1324	T1501	T1502	arg1Of	domain,(
R1325	T1503	T1502	arg2Of	RHD,(
R1326	T1504	T1502	arg3Of	),(
R1327	T1506	T1507	arg1Of	homo-,or
R1328	T1507	T1505	arg2Of	or,for
R1329	T1508	T1509	arg1Of	hetero-dimerization,and
R1330	T1509	T1507	arg2Of	and,or
R1331	T1510	T1509	arg2Of	DNA-binding,and
R1332	T1513	T1511	arg1Of	activity,The
R1333	T1513	T1512	arg1Of	activity,transcriptional
R1334	T1513	T1514	arg1Of	activity,of
R1335	T1513	T1518	arg1Of	activity,depends
R1336	T1517	T1514	arg2Of	complex,of
R1337	T1517	T1515	arg1Of	complex,the
R1338	T1517	T1516	arg1Of	complex,NF-κB
R1339	T1518	T1519	arg1Of	depends,on
R1340	T1518	T1522	arg1Of	depends,since
R1341	T1521	T1519	arg2Of	composition,on
R1342	T1521	T1520	arg1Of	composition,dimer
R1343	T1527	T1523	arg1Of	domains,C-terminal
R1344	T1527	T1524	arg1Of	domains,unrelated
R1345	T1527	T1525	arg1Of	domains,transcriptional
R1346	T1527	T1526	arg1Of	domains,activation
R1347	T1527	T1528	arg1Of	domains,are
R1348	T1527	T1529	arg1Of	domains,present
R1349	T1528	T1522	arg2Of	are,since
R1350	T1529	T1528	arg2Of	present,are
R1351	T1529	T1531	arg1Of	present,in
R1352	T1531	T1530	arg1Of	in,exclusively
R1353	T1532	T1533	arg1Of	p65,","
R1354	T1533	T1535	arg1Of	",",and
R1355	T1534	T1533	arg2Of	RelB,","
R1356	T1535	T1531	arg2Of	and,in
R1357	T1536	T1535	arg2Of	c-Rel,and
R1358	T1536	T1537	arg1Of	c-Rel,(
R1359	T1538	T1537	arg2Of	2,(
R1360	T1539	T1537	arg3Of	),(
R1361	T1540	T1541	arg1Of	Inhibitors,of
R1362	T1540	T1546	arg1Of	Inhibitors,associate
R1363	T1540	T1552	arg1Of	Inhibitors,interfere
R1364	T1542	T1541	arg2Of	NF-κB,of
R1365	T1542	T1543	arg1Of	NF-κB,(
R1366	T1544	T1543	arg2Of	IκB,(
R1367	T1545	T1543	arg3Of	),(
R1368	T1546	T1547	arg1Of	associate,with
R1369	T1546	T1551	arg1Of	associate,and
R1370	T1550	T1547	arg2Of	complex,with
R1371	T1550	T1548	arg1Of	complex,the
R1372	T1550	T1549	arg1Of	complex,NF-κB
R1373	T1552	T1551	arg2Of	interfere,and
R1374	T1552	T1553	arg1Of	interfere,with
R1375	T1555	T1553	arg2Of	binding,with
R1376	T1555	T1554	arg1Of	binding,its
R1377	T1555	T1556	arg1Of	binding,to
R1378	T1557	T1556	arg2Of	DNA,to
R1379	T1557	T1558	arg1Of	DNA,(
R1380	T1559	T1558	arg2Of	3,(
R1381	T1560	T1558	arg3Of	),(
R1382	T1564	T1561	arg2Of	pathway,In
R1383	T1564	T1562	arg1Of	pathway,the
R1384	T1564	T1563	arg1Of	pathway,canonical
R1385	T1564	T1565	arg1Of	pathway,of
R1386	T1567	T1565	arg2Of	activation,of
R1387	T1567	T1566	arg1Of	activation,NF-κB
R1388	T1572	T1569	arg1Of	kinase,the
R1389	T1572	T1570	arg2Of	kinase,activated
R1390	T1572	T1571	arg1Of	kinase,IκB
R1391	T1572	T1573	arg1Of	kinase,(
R1392	T1572	T1576	arg1Of	kinase,phosphorylates
R1393	T1574	T1573	arg2Of	IKK,(
R1394	T1575	T1573	arg3Of	),(
R1395	T1576	T1561	arg1Of	phosphorylates,In
R1396	T1576	T1568	arg1Of	phosphorylates,","
R1397	T1576	T1578	arg1Of	phosphorylates,at
R1398	T1577	T1576	arg2Of	IκB,phosphorylates
R1399	T1581	T1578	arg2Of	residues,at
R1400	T1581	T1579	arg1Of	residues,specific
R1401	T1581	T1580	arg1Of	residues,serine
R1402	T1581	T1582	arg1Of	residues,that
R1403	T1581	T1583	arg1Of	residues,target
R1404	T1585	T1583	arg2Of	protein,target
R1405	T1585	T1584	arg1Of	protein,the
R1406	T1585	T1586	arg1Of	protein,to
R1407	T1587	T1588	arg1Of	ubiquitination,and
R1408	T1588	T1586	arg2Of	and,to
R1409	T1588	T1591	arg1Of	and,","
R1410	T1588	T1592	arg1Of	and,which
R1411	T1588	T1593	arg1Of	and,releases
R1412	T1590	T1588	arg2Of	degradation,and
R1413	T1590	T1589	arg1Of	degradation,proteasomal
R1414	T1597	T1593	arg2Of	complex,releases
R1415	T1597	T1594	arg1Of	complex,the
R1416	T1597	T1595	arg1Of	complex,functional
R1417	T1597	T1596	arg1Of	complex,NF-κB
R1418	T1597	T1598	arg1Of	complex,in
R1419	T1600	T1598	arg2Of	nucleus,in
R1420	T1600	T1599	arg1Of	nucleus,the
R1421	T1601	T1602	arg1Of	IκB-α,","
R1422	T1601	T1613	arg1Of	IκB-α,is
R1423	T1601	T1614	arg2Of	IκB-α,phosphorylated
R1424	T1601	T1627	arg2Of	IκB-α,ubiquitylated
R1425	T1605	T1604	arg1Of	abundant,most
R1426	T1606	T1602	arg2Of	inhibitor,","
R1427	T1606	T1603	arg1Of	inhibitor,the
R1428	T1606	T1605	arg1Of	inhibitor,abundant
R1429	T1606	T1607	arg1Of	inhibitor,of
R1430	T1608	T1607	arg2Of	NF-κB,of
R1431	T1608	T1609	arg1Of	NF-κB,(
R1432	T1610	T1609	arg2Of	4,(
R1433	T1611	T1609	arg3Of	),(
R1434	T1614	T1625	arg1Of	phosphorylated,and
R1435	T1616	T1614	arg1Of	IKK,phosphorylated
R1436	T1616	T1615	arg2Of	IKK,by
R1437	T1616	T1617	arg1Of	IKK,at
R1438	T1618	T1619	arg1Of	Ser32,and
R1439	T1619	T1617	arg2Of	and,at
R1440	T1620	T1619	arg2Of	Ser36,and
R1441	T1620	T1621	arg1Of	Ser36,(
R1442	T1622	T1621	arg2Of	5,(
R1443	T1623	T1621	arg3Of	),(
R1444	T1625	T1612	arg1Of	and,","
R1445	T1625	T1613	arg2Of	and,is
R1446	T1625	T1624	arg1Of	and,","
R1447	T1627	T1625	arg2Of	ubiquitylated,and
R1448	T1627	T1626	arg1Of	ubiquitylated,subsequently
R1449	T1627	T1628	arg1Of	ubiquitylated,at
R1450	T1629	T1630	arg1Of	Lys21,and
R1451	T1630	T1628	arg2Of	and,at
R1452	T1630	T1632	modOf	and,to
R1453	T1630	T1633	arg1Of	and,be
R1454	T1630	T1634	arg2Of	and,degraded
R1455	T1631	T1630	arg2Of	Lys22,and
R1456	T1634	T1632	arg1Of	degraded,to
R1457	T1634	T1633	arg2Of	degraded,be
R1458	T1638	T1634	arg1Of	proteasome,degraded
R1459	T1638	T1635	arg2Of	proteasome,by
R1460	T1638	T1636	arg1Of	proteasome,the
R1461	T1638	T1637	arg1Of	proteasome,26S
R1462	T1638	T1639	arg1Of	proteasome,(
R1463	T1640	T1639	arg2Of	6,(
R1464	T1641	T1639	arg3Of	),(
R1465	T1644	T1642	arg1Of	activity,The
R1466	T1644	T1643	arg1Of	activity,NF-κB
R1467	T1644	T1645	arg1Of	activity,is
R1468	T1644	T1646	arg2Of	activity,enhanced
R1469	T1646	T1645	arg2Of	enhanced,is
R1470	T1646	T1647	arg1Of	enhanced,by
R1471	T1646	T1651	arg1Of	enhanced,at
R1472	T1648	T1647	arg2Of	phosphorylation,by
R1473	T1648	T1649	arg1Of	phosphorylation,of
R1474	T1650	T1649	arg2Of	p65,of
R1475	T1652	T1651	arg2Of	Ser276,at
R1476	T1654	T1655	arg1Of	PKA,and
R1477	T1655	T1660	arg1Of	and,","
R1478	T1656	T1655	arg2Of	MSK1,and
R1479	T1656	T1657	arg1Of	MSK1,(
R1480	T1658	T1657	arg2Of	"7,8",(
R1481	T1659	T1657	arg3Of	),(
R1482	T1660	T1646	arg1Of	",",enhanced
R1483	T1660	T1653	arg2Of	",",by
R1484	T1660	T1662	arg1Of	",",by
R1485	T1661	T1660	arg2Of	Ser311,","
R1486	T1663	T1664	arg1Of	PKCζ,(
R1487	T1663	T1667	arg1Of	PKCζ,and
R1488	T1665	T1664	arg2Of	9,(
R1489	T1666	T1664	arg3Of	),(
R1490	T1667	T1662	arg2Of	and,by
R1491	T1667	T1669	arg1Of	and,by
R1492	T1668	T1667	arg2Of	Ser536,and
R1493	T1670	T1669	arg2Of	IKKα,by
R1494	T1670	T1671	arg1Of	IKKα,(
R1495	T1672	T1671	arg2Of	"10,11",(
R1496	T1673	T1671	arg3Of	),(
R1497	T1674	T1675	arg1Of	Acetylation,of
R1498	T1674	T1677	arg1Of	Acetylation,at
R1499	T1674	T1681	arg1Of	Acetylation,increases
R1500	T1674	T1686	arg1Of	Acetylation,impairs
R1501	T1676	T1675	arg2Of	p65,of
R1502	T1678	T1679	arg1Of	Lys218,and
R1503	T1679	T1677	arg2Of	and,at
R1504	T1680	T1679	arg2Of	Lys221,and
R1505	T1681	T1685	arg1Of	increases,and
R1506	T1684	T1681	arg2Of	binding,increases
R1507	T1684	T1682	arg1Of	binding,the
R1508	T1684	T1683	arg1Of	binding,DNA
R1509	T1685	T1692	arg1Of	and,and
R1510	T1686	T1685	arg2Of	impairs,and
R1511	T1688	T1686	arg2Of	association,impairs
R1512	T1688	T1687	arg1Of	association,the
R1513	T1688	T1689	arg1Of	association,with
R1514	T1690	T1689	arg2Of	IκB-α,with
R1515	T1692	T1691	arg1Of	and,","
R1516	T1693	T1694	arg1Of	acetylation,at
R1517	T1693	T1696	arg1Of	acetylation,enhances
R1518	T1695	T1694	arg2Of	Lys310,at
R1519	T1696	T1692	arg2Of	enhances,and
R1520	T1700	T1696	arg2Of	activity,enhances
R1521	T1700	T1697	arg1Of	activity,the
R1522	T1700	T1698	arg1Of	activity,p65
R1523	T1700	T1699	arg1Of	activity,transcriptional
R1524	T1700	T1701	arg1Of	activity,(
R1525	T1702	T1701	arg2Of	"12,13",(
R1526	T1703	T1701	arg3Of	),(
R1527	T1705	T1704	arg1Of	turn,Post-activation
R1528	T1705	T1706	arg1Of	turn,off
R1529	T1708	T1707	arg1Of	NF-κB,of
R1530	T1708	T1709	arg1Of	NF-κB,is
R1531	T1708	T1710	arg2Of	NF-κB,regulated
R1532	T1710	T1705	arg2Of	regulated,turn
R1533	T1710	T1709	arg2Of	regulated,is
R1534	T1710	T1715	arg1Of	regulated,through
R1535	T1714	T1710	arg1Of	loop,regulated
R1536	T1714	T1711	arg2Of	loop,by
R1537	T1714	T1712	arg1Of	loop,negative
R1538	T1714	T1713	arg1Of	loop,feedback
R1539	T1716	T1715	arg2Of	inhibitors,through
R1540	T1716	T1717	arg1Of	inhibitors,under
R1541	T1716	T1723	arg1Of	inhibitors,","
R1542	T1716	T1725	arg1Of	inhibitors,as
R1543	T1720	T1717	arg2Of	control,under
R1544	T1720	T1718	arg1Of	control,the
R1545	T1720	T1719	arg1Of	control,transcriptional
R1546	T1720	T1721	arg1Of	control,of
R1547	T1722	T1721	arg2Of	NF-κB,of
R1548	T1725	T1724	arg1Of	as,such
R1549	T1726	T1727	arg1Of	IκB-α,and
R1550	T1728	T1727	arg2Of	ubiquitin-editing,and
R1551	T1730	T1725	arg2Of	A20,as
R1552	T1730	T1726	arg1Of	A20,IκB-α
R1553	T1730	T1728	arg1Of	A20,ubiquitin-editing
R1554	T1730	T1729	arg1Of	A20,protein
R1555	T1730	T1731	arg1Of	A20,(
R1556	T1732	T1731	arg2Of	14–20,(
R1557	T1733	T1731	arg3Of	),(
R1558	T1734	T1735	arg1Of	Deacetylation,of
R1559	T1734	T1737	arg1Of	Deacetylation,by
R1560	T1734	T1743	arg1Of	Deacetylation,or
R1561	T1736	T1735	arg2Of	p65,of
R1562	T1739	T1740	arg1Of	deacetylase-3,or
R1563	T1740	T1737	arg2Of	or,by
R1564	T1740	T1738	arg1Of	or,histone
R1565	T1741	T1740	arg2Of	SIRT1,or
R1566	T1743	T1742	arg1Of	or,","
R1567	T1743	T1751	arg1Of	or,down-regulate
R1568	T1744	T1743	arg2Of	acetylation,or
R1569	T1744	T1745	arg1Of	acetylation,of
R1570	T1744	T1747	arg1Of	acetylation,at
R1571	T1746	T1745	arg2Of	p65,of
R1572	T1748	T1749	arg1Of	Lys122,and
R1573	T1749	T1747	arg2Of	and,at
R1574	T1750	T1749	arg2Of	Lys123,and
R1575	T1754	T1751	arg2Of	activity,down-regulate
R1576	T1754	T1752	arg1Of	activity,the
R1577	T1754	T1753	arg1Of	activity,NF-κB
R1578	T1754	T1755	arg1Of	activity,(
R1579	T1756	T1755	arg2Of	"12,21,22",(
R1580	T1757	T1755	arg3Of	),(
R1581	T1759	T1758	arg1Of	activation,Persistent
R1582	T1759	T1760	arg1Of	activation,of
R1583	T1759	T1762	arg1Of	activation,occurs
R1584	T1759	T1778	arg1Of	activation,enhances
R1585	T1761	T1760	arg2Of	NF-κB,of
R1586	T1762	T1763	arg1Of	occurs,in
R1587	T1762	T1777	arg1Of	occurs,and
R1588	T1766	T1764	arg1Of	virus-1,human
R1589	T1766	T1765	arg1Of	virus-1,immunodeficiency
R1590	T1766	T1767	arg1Of	virus-1,(
R1591	T1768	T1767	arg2Of	HIV-1,(
R1592	T1769	T1767	arg3Of	),(
R1593	T1771	T1772	arg1Of	monocytes,","
R1594	T1772	T1774	arg1Of	",",and
R1595	T1773	T1772	arg2Of	macrophages,","
R1596	T1774	T1763	arg2Of	and,in
R1597	T1774	T1766	arg1Of	and,virus-1
R1598	T1774	T1770	arg1Of	and,-infected
R1599	T1775	T1774	arg2Of	microglia,and
R1600	T1777	T1776	arg1Of	and,","
R1601	T1778	T1777	arg2Of	enhances,and
R1602	T1780	T1778	arg2Of	expression,enhances
R1603	T1780	T1779	arg1Of	expression,the
R1604	T1780	T1781	arg1Of	expression,of
R1605	T1783	T1781	arg2Of	genes,of
R1606	T1783	T1782	arg1Of	genes,NF-κB-responsive
R1607	T1783	T1784	arg1Of	genes,","
R1608	T1783	T1785	arg1Of	genes,including
R1609	T1787	T1786	arg1Of	cytokines,pro-inflammatory
R1610	T1787	T1788	arg1Of	cytokines,","
R1611	T1788	T1792	arg1Of	",",and
R1612	T1791	T1788	arg2Of	molecules,","
R1613	T1791	T1789	arg1Of	molecules,cell
R1614	T1791	T1790	arg1Of	molecules,adhesion
R1615	T1792	T1785	arg2Of	and,including
R1616	T1793	T1792	arg2Of	chemokines,and
R1617	T1793	T1794	arg1Of	chemokines,(
R1618	T1795	T1794	arg2Of	23–25,(
R1619	T1796	T1794	arg3Of	),(
R1620	T1798	T1797	arg1Of	inflammation,Chronic
R1621	T1798	T1799	arg1Of	inflammation,is
R1622	T1799	T1808	arg1Of	is,in
R1623	T1802	T1799	arg2Of	cause,is
R1624	T1802	T1800	arg1Of	cause,a
R1625	T1802	T1801	arg1Of	cause,major
R1626	T1802	T1803	arg1Of	cause,of
R1627	T1807	T1803	arg2Of	dysfunction,of
R1628	T1807	T1804	arg1Of	dysfunction,immune
R1629	T1807	T1805	arg1Of	dysfunction,and
R1630	T1807	T1806	arg1Of	dysfunction,neuron
R1631	T1809	T1808	arg2Of	AIDS,in
R1632	T1809	T1810	arg1Of	AIDS,(
R1633	T1811	T1810	arg2Of	"26,27",(
R1634	T1812	T1810	arg3Of	),(
R1635	T1817	T1815	arg1Of	hosts,non-human
R1636	T1817	T1816	arg1Of	hosts,primate
R1637	T1817	T1818	arg1Of	hosts,for
R1638	T1817	T1822	arg1Of	hosts,","
R1639	T1817	T1824	arg1Of	hosts,as
R1640	T1817	T1832	arg1Of	hosts,lack
R1641	T1817	T1837	arg1Of	hosts,do
R1642	T1817	T1839	arg1Of	hosts,develop
R1643	T1821	T1818	arg2Of	virus,for
R1644	T1821	T1819	arg1Of	virus,simian
R1645	T1821	T1820	arg1Of	virus,immunodeficiency
R1646	T1824	T1823	arg1Of	as,such
R1647	T1827	T1825	arg1Of	monkeys,African
R1648	T1827	T1826	arg1Of	monkeys,green
R1649	T1827	T1828	arg1Of	monkeys,and
R1650	T1828	T1824	arg2Of	and,as
R1651	T1830	T1828	arg2Of	mangabey,and
R1652	T1830	T1829	arg1Of	mangabey,sooty
R1653	T1832	T1836	arg1Of	lack,and
R1654	T1835	T1832	arg2Of	activation,lack
R1655	T1835	T1833	arg1Of	activation,aberrant
R1656	T1835	T1834	arg1Of	activation,immune
R1657	T1836	T1813	arg1Of	and,Consistently
R1658	T1836	T1814	arg1Of	and,","
R1659	T1836	T1831	arg1Of	and,","
R1660	T1839	T1836	arg2Of	develop,and
R1661	T1839	T1837	arg2Of	develop,do
R1662	T1839	T1838	arg1Of	develop,not
R1663	T1839	T1841	arg1Of	develop,despite
R1664	T1840	T1839	arg2Of	AIDS,develop
R1665	T1844	T1841	arg2Of	replication,despite
R1666	T1844	T1842	arg1Of	replication,high
R1667	T1844	T1843	arg1Of	replication,virus
R1668	T1844	T1845	arg1Of	replication,(
R1669	T1846	T1845	arg2Of	"28,29",(
R1670	T1847	T1845	arg3Of	),(
R1671	T1850	T1858	arg1Of	understanding,may
R1672	T1850	T1859	arg1Of	understanding,provide
R1673	T1852	T1850	arg2Of	mechanisms,understanding
R1674	T1852	T1851	arg1Of	mechanisms,the
R1675	T1852	T1853	arg1Of	mechanisms,of
R1676	T1852	T1856	arg1Of	mechanisms,by
R1677	T1855	T1853	arg2Of	deregulation,of
R1678	T1855	T1854	arg1Of	deregulation,NF-κB
R1679	T1857	T1856	arg2Of	HIV-1,by
R1680	T1859	T1848	arg1Of	provide,Thus
R1681	T1859	T1849	arg1Of	provide,","
R1682	T1859	T1858	arg2Of	provide,may
R1683	T1859	T1862	arg1Of	provide,into
R1684	T1861	T1859	arg2Of	insights,provide
R1685	T1861	T1860	arg1Of	insights,further
R1686	T1864	T1862	arg2Of	pathogenesis,into
R1687	T1864	T1863	arg1Of	pathogenesis,AIDS
R1688	T1867	T1865	arg2Of	entry,In
R1689	T1867	T1866	arg1Of	entry,HIV-1
R1690	T1870	T1869	arg1Of	binding,the
R1691	T1870	T1871	arg1Of	binding,of
R1692	T1870	T1876	arg1Of	binding,to
R1693	T1870	T1878	arg1Of	binding,induces
R1694	T1875	T1871	arg2Of	envelope,of
R1695	T1875	T1872	arg1Of	envelope,the
R1696	T1875	T1873	arg1Of	envelope,gp120
R1697	T1875	T1874	arg1Of	envelope,viral
R1698	T1877	T1876	arg2Of	CD4,to
R1699	T1878	T1865	arg1Of	induces,In
R1700	T1878	T1868	arg1Of	induces,","
R1701	T1878	T1882	arg1Of	induces,by
R1702	T1881	T1878	arg2Of	activity,induces
R1703	T1881	T1879	arg1Of	activity,the
R1704	T1881	T1880	arg1Of	activity,NF-κB
R1705	T1883	T1884	arg1Of	activation,of
R1706	T1883	T1889	arg1Of	activation,and
R1707	T1885	T1884	arg2Of	IKK,of
R1708	T1885	T1886	arg1Of	IKK,(
R1709	T1887	T1886	arg2Of	30,(
R1710	T1888	T1886	arg3Of	),(
R1711	T1889	T1882	arg2Of	and,by
R1712	T1890	T1889	arg2Of	procaspase,and
R1713	T1890	T1891	arg1Of	procaspase,8
R1714	T1890	T1892	arg1Of	procaspase,(
R1715	T1893	T1892	arg2Of	31,(
R1716	T1894	T1892	arg3Of	),(
R1717	T1897	T1895	arg2Of	integration,Following
R1718	T1897	T1896	arg1Of	integration,viral
R1719	T1904	T1899	arg1Of	protein,the
R1720	T1904	T1900	arg1Of	protein,early
R1721	T1904	T1901	arg2Of	protein,encoded
R1722	T1904	T1902	arg1Of	protein,HIV-1
R1723	T1904	T1903	arg1Of	protein,Tat
R1724	T1904	T1905	arg1Of	protein,interacts
R1725	T1904	T1915	arg1Of	protein,sustain
R1726	T1905	T1895	arg1Of	interacts,Following
R1727	T1905	T1898	arg1Of	interacts,","
R1728	T1905	T1906	arg1Of	interacts,with
R1729	T1909	T1908	arg1Of	RNA,HIV-1
R1730	T1909	T1910	arg1Of	RNA,and
R1731	T1910	T1906	arg2Of	and,with
R1732	T1910	T1907	arg1Of	and,the
R1733	T1913	T1910	arg2Of	factors,and
R1734	T1913	T1911	arg1Of	factors,host
R1735	T1913	T1912	arg1Of	factors,cell
R1736	T1915	T1905	arg2Of	sustain,interacts
R1737	T1915	T1914	arg1Of	sustain,to
R1738	T1918	T1915	arg2Of	replication,sustain
R1739	T1918	T1916	arg1Of	replication,the
R1740	T1918	T1917	arg1Of	replication,viral
R1741	T1919	T1920	arg1Of	Tat,binds
R1742	T1920	T1921	arg1Of	binds,to
R1743	T1920	T1964	modOf	binds,to
R1744	T1924	T1922	arg1Of	structures,RNA
R1745	T1924	T1923	arg1Of	structures,stem-loop
R1746	T1924	T1925	arg2Of	structures,generated
R1747	T1924	T1933	arg1Of	structures,","
R1748	T1924	T1934	arg1Of	structures,including
R1749	T1924	T1945	arg1Of	structures,","
R1750	T1925	T1926	arg1Of	generated,by
R1751	T1929	T1926	arg2Of	end,by
R1752	T1992	T1991	arg2Of	TFIID,","
R1753	T1992	T1993	arg1Of	TFIID,(
R1754	T1994	T1993	arg2Of	36,(
R1755	T1929	T1927	arg1Of	end,the
R1756	T1995	T1993	arg3Of	),(
R1757	T1996	T2001	arg1Of	",",","
R1758	T1929	T1928	arg1Of	end,5′
R1759	T1997	T1996	arg2Of	E2F-4,","
R1760	T1997	T1998	arg1Of	E2F-4,(
R1761	T1929	T1930	arg1Of	end,of
R1762	T1932	T1930	arg2Of	transcripts,of
R1763	T1999	T1998	arg2Of	37,(
R1764	T2000	T1998	arg3Of	),(
R1765	T2001	T1986	arg2Of	",",as
R1766	T1932	T1931	arg1Of	transcripts,target
R1767	T2002	T2003	arg1Of	C/EBPβ,(
R1768	T2002	T2006	arg1Of	C/EBPβ,","
R1769	T1938	T1934	arg2Of	element,including
R1770	T2004	T2003	arg2Of	38,(
R1771	T2005	T2003	arg3Of	),(
R1772	T2006	T2012	arg1Of	",",and
R1773	T2008	T2006	arg2Of	T1/CDK9,","
R1774	T2008	T2007	arg1Of	T1/CDK9,cyclin
R1775	T2008	T2009	arg1Of	T1/CDK9,(
R1776	T2010	T2009	arg2Of	"39,40",(
R1777	T2011	T2009	arg3Of	),(
R1778	T2012	T2001	arg2Of	and,","
R1779	T1938	T1935	arg1Of	element,the
R1780	T1938	T1936	arg1Of	element,HIV-1
R1781	T1938	T1937	arg1Of	element,transactivation-responsive
R1782	T2015	T2013	arg1Of	acetyltransferases,the
R1783	T2015	T2014	arg1Of	acetyltransferases,histone
R1784	T2016	T2015	arg1Of	p300/CBP,acetyltransferases
R1785	T2016	T2017	arg1Of	p300/CBP,and
R1786	T1938	T1939	arg1Of	element,(
R1787	T2017	T2012	arg2Of	and,and
R1788	T1938	T1942	arg1Of	element,(
R1789	T2018	T2017	arg2Of	P/CAF,and
R1790	T2018	T2019	arg1Of	P/CAF,(
R1791	T1940	T1939	arg2Of	TAR,(
R1792	T2020	T2019	arg2Of	41–43,(
R1793	T2021	T2019	arg3Of	),(
R1794	T2023	T2024	arg1Of	released,from
R1795	T2026	T2024	arg2Of	cells,from
R1796	T2026	T2025	arg1Of	cells,HIV-1-infected
R1797	T1941	T1939	arg3Of	),(
R1798	T2028	T2029	arg1Of	Tat,deregulates
R1799	T2028	T2034	arg1Of	Tat,binding
R1800	T2029	T2022	arg1Of	deregulates,When
R1801	T2029	T2023	modOf	deregulates,released
R1802	T2029	T2027	arg1Of	deregulates,","
R1803	T2029	T2033	arg1Of	deregulates,by
R1804	T1943	T1942	arg2Of	32,(
R1805	T2032	T2029	arg2Of	signaling,deregulates
R1806	T2032	T2030	arg1Of	signaling,the
R1807	T2032	T2031	arg1Of	signaling,cell
R1808	T2034	T2033	arg2Of	binding,by
R1809	T2034	T2035	arg1Of	binding,to
R1810	T1944	T1942	arg3Of	),(
R1811	T2037	T2035	arg2Of	receptors,to
R1812	T2037	T2036	arg1Of	receptors,cell
R1813	T2037	T2038	arg1Of	receptors,","
R1814	T2037	T2040	arg1Of	receptors,as
R1815	T1945	T1953	arg1Of	",",(
R1816	T2040	T2039	arg1Of	as,such
R1817	T2041	T2042	arg1Of	integrins,(
R1818	T2041	T2045	arg1Of	integrins,","
R1819	T1945	T1956	arg1Of	",",and
R1820	T2043	T2042	arg2Of	44,(
R1821	T2044	T2042	arg3Of	),(
R1822	T1949	T1945	arg2Of	β,","
R1823	T2045	T2051	arg1Of	",",and
R1824	T2047	T2045	arg2Of	receptor,","
R1825	T2047	T2046	arg1Of	receptor,Flk1/KDR
R1826	T2047	T2048	arg1Of	receptor,(
R1827	T2049	T2048	arg2Of	45,(
R1828	T2050	T2048	arg3Of	),(
R1829	T2051	T2040	arg2Of	and,as
R1830	T1949	T1946	arg1Of	β,tumor
R1831	T1949	T1947	arg1Of	β,necrosis
R1832	T2053	T2051	arg2Of	receptors,and
R1833	T2053	T2052	arg1Of	receptors,chemokine
R1834	T2053	T2054	arg1Of	receptors,(
R1835	T1949	T1948	arg1Of	β,factor
R1836	T2055	T2054	arg2Of	46,(
R1837	T1949	T1950	arg1Of	β,(
R1838	T1951	T1950	arg2Of	TNFβ,(
R1839	T2056	T2054	arg3Of	),(
R1840	T2057	T2059	arg1Of	We,reported
R1841	T2059	T2058	arg1Of	reported,first
R1842	T1952	T1950	arg3Of	),(
R1843	T2061	T2062	arg1Of	NF-κB,was
R1844	T2061	T2064	arg1Of	NF-κB,active
R1845	T2062	T2059	arg2Of	was,reported
R1846	T2062	T2060	arg1Of	was,that
R1847	T2064	T2062	arg2Of	active,was
R1848	T2064	T2063	arg1Of	active,constitutively
R1849	T2064	T2065	arg1Of	active,in
R1850	T2067	T2065	arg2Of	cells,in
R1851	T2067	T2066	arg1Of	cells,Jurkat
R1852	T2067	T2068	arg1Of	cells,that
R1853	T2067	T2070	arg1Of	cells,expressed
R1854	T1954	T1953	arg2Of	33,(
R1855	T2070	T2069	arg1Of	expressed,stably
R1856	T1955	T1953	arg3Of	),(
R1857	T1956	T1921	arg2Of	and,to
R1858	T2073	T2070	arg2Of	gene,expressed
R1859	T2073	T2071	arg1Of	gene,the
R1860	T2073	T2072	arg1Of	gene,Tat
R1861	T2073	T2074	arg1Of	gene,(
R1862	T1956	T1961	arg1Of	and,(
R1863	T2075	T2074	arg2Of	47,(
R1864	T1957	T1956	arg2Of	interleukin-6,and
R1865	T2076	T2074	arg3Of	),(
R1866	T1957	T1958	arg1Of	interleukin-6,(
R1867	T1959	T1958	arg2Of	IL-6,(
R1868	T2079	T2078	arg1Of	transfection,gene
R1869	T2079	T2080	arg1Of	transfection,or
R1870	T2080	T2077	arg2Of	or,Following
R1871	T1960	T1958	arg3Of	),(
R1872	T2082	T2080	arg2Of	transduction,or
R1873	T2082	T2081	arg1Of	transduction,protein
R1874	T2084	T2085	arg1Of	Tat,induced
R1875	T1962	T1961	arg2Of	34,(
R1876	T2084	T2099	arg1Of	Tat,increased
R1877	T2084	T2105	arg1Of	Tat,inhibiting
R1878	T2085	T2098	arg1Of	induced,and
R1879	T1963	T1961	arg3Of	),(
R1880	T2088	T2087	arg1Of	activity,IKK
R1881	T2088	T2089	arg1Of	activity,and
R1882	T1965	T1964	arg1Of	activate,to
R1883	T1967	T1965	arg2Of	transcription,activate
R1884	T2089	T2085	arg2Of	and,induced
R1885	T2089	T2086	arg1Of	and,the
R1886	T2089	T2092	arg1Of	and,of
R1887	T1967	T1966	arg1Of	transcription,gene
R1888	T2091	T2089	arg2Of	degradation,and
R1889	T2091	T2090	arg1Of	degradation,proteasomal
R1890	T1970	T1971	arg1Of	Tat,promotes
R1891	T2093	T2092	arg2Of	IκB-α,of
R1892	T2093	T2094	arg1Of	IκB-α,(
R1893	T2095	T2094	arg2Of	48,(
R1894	T2096	T2094	arg3Of	),(
R1895	T2098	T2077	arg1Of	and,Following
R1896	T2098	T2083	arg1Of	and,","
R1897	T2098	T2097	arg1Of	and,","
R1898	T2099	T2098	arg2Of	increased,and
R1899	T2099	T2104	arg1Of	increased,by
R1900	T1970	T1978	arg1Of	Tat,interacting
R1901	T1971	T1968	arg1Of	promotes,Indeed
R1902	T2103	T2099	arg2Of	activity,increased
R1903	T2103	T2100	arg1Of	activity,the
R1904	T2103	T2101	arg1Of	activity,p65
R1905	T2103	T2102	arg1Of	activity,transcriptional
R1906	T2105	T2104	arg2Of	inhibiting,by
R1907	T1971	T1969	arg1Of	promotes,","
R1908	T1971	T1977	arg1Of	promotes,by
R1909	T2108	T2105	arg2Of	deacetylation,inhibiting
R1910	T2108	T2106	arg1Of	deacetylation,the
R1911	T2108	T2107	arg1Of	deacetylation,SIRT-1-mediated
R1912	T2108	T2109	arg1Of	deacetylation,of
R1913	T1974	T1972	arg1Of	initiation,the
R1914	T2111	T2109	arg2Of	Lys310,of
R1915	T2111	T2110	arg1Of	Lys310,p65
R1916	T2111	T2112	arg1Of	Lys310,(
R1917	T2113	T2112	arg2Of	49,(
R1918	T2114	T2112	arg3Of	),(
R1919	T1974	T1973	arg1Of	initiation,transcriptional
R1920	T1974	T1975	arg1Of	initiation,and
R1921	T2116	T2115	arg1Of	findings,These
R1922	T2116	T2117	arg1Of	findings,suggested
R1923	T2117	T2127	arg1Of	suggested,;
R1924	T1975	T1971	arg2Of	and,promotes
R1925	T2119	T2120	arg1Of	Tat,modulates
R1926	T2120	T2117	arg2Of	modulates,suggested
R1927	T2120	T2118	arg1Of	modulates,that
R1928	T1976	T1975	arg2Of	elongation,and
R1929	T2122	T2120	arg2Of	enzymes,modulates
R1930	T2122	T2121	arg1Of	enzymes,crucial
R1931	T2122	T2123	arg2Of	enzymes,involved
R1932	T2123	T2124	arg1Of	involved,in
R1933	T1978	T1977	arg2Of	interacting,by
R1934	T2126	T2124	arg2Of	signaling,in
R1935	T2126	T2125	arg1Of	signaling,NF-κB
R1936	T1978	T1979	arg1Of	interacting,with
R1937	T1981	T1982	arg1Of	factors,and
R1938	T2131	T2127	arg2Of	was,;
R1939	T2131	T2128	arg1Of	was,however
R1940	T2131	T2129	arg1Of	was,","
R1941	T2132	T2131	arg2Of	unclear,was
R1942	T2133	T2130	arg1Of	how,it
R1943	T2133	T2131	arg1Of	how,was
R1944	T2133	T2132	arg1Of	how,unclear
R1945	T2134	T2135	arg1Of	Tat,could
R1946	T2134	T2136	arg1Of	Tat,subvert
R1947	T2136	T2133	arg1Of	subvert,how
R1948	T2136	T2135	arg2Of	subvert,could
R1949	T2139	T2136	arg2Of	feedback,subvert
R1950	T2139	T2137	arg1Of	feedback,the
R1951	T2139	T2138	arg1Of	feedback,negative
R1952	T2139	T2140	arg1Of	feedback,of
R1953	T2139	T2142	arg1Of	feedback,","
R1954	T2139	T2143	arg1Of	feedback,which
R1955	T2139	T2144	arg1Of	feedback,is
R1956	T2139	T2146	arg1Of	feedback,dependent
R1957	T2141	T2140	arg2Of	NF-κB,of
R1958	T1982	T1979	arg2Of	and,with
R1959	T1982	T1980	arg1Of	and,transacting
R1960	T2146	T2144	arg2Of	dependent,is
R1961	T2146	T2145	arg1Of	dependent,mainly
R1962	T2146	T2147	arg1Of	dependent,on
R1963	T1982	T1984	arg1Of	and,","
R1964	T1982	T1986	arg1Of	and,as
R1965	T1983	T1982	arg2Of	cofactors,and
R1966	T1986	T1985	arg1Of	as,such
R1967	T2149	T2148	arg1Of	novo,de
R1968	T2150	T2147	arg2Of	synthesis,on
R1969	T2150	T2149	arg1Of	synthesis,novo
R1970	T2150	T2151	arg1Of	synthesis,of
R1971	T2152	T2151	arg2Of	IκB-α,of
R1972	T2152	T2153	arg1Of	IκB-α,(
R1973	T1987	T1988	arg1Of	Sp1,(
R1974	T2154	T2153	arg2Of	"15,17",(
R1975	T2155	T2153	arg3Of	),(
R1976	T1987	T1991	arg1Of	Sp1,","
R1977	T2156	T2158	arg1Of	We,found
R1978	T1989	T1988	arg2Of	35,(
R1979	T2158	T2157	arg1Of	found,previously
R1980	T2160	T2161	arg1Of	IκB-α,binds
R1981	T2160	T2165	arg1Of	IκB-α,promotes
R1982	T1990	T1988	arg3Of	),(
R1983	T2161	T2162	arg1Of	binds,to
R1984	T2161	T2164	arg1Of	binds,and
R1985	T2163	T2162	arg2Of	Tat,to
R1986	T1991	T1996	arg1Of	",",","
R1987	T2164	T2158	arg2Of	and,found
R1988	T2164	T2159	arg1Of	and,that
R1989	T2165	T2164	arg2Of	promotes,and
R1990	T2187	T2184	arg2Of	turn,counteracts
R1991	T2168	T2165	arg2Of	export,promotes
R1992	T2168	T2166	arg1Of	export,the
R1993	T2168	T2167	arg1Of	export,nuclear
R1994	T2168	T2169	arg1Of	export,of
R1995	T2172	T2169	arg2Of	transactivator,of
R1996	T2172	T2170	arg1Of	transactivator,the
R1997	T2172	T2171	arg1Of	transactivator,viral
R1998	T2172	T2173	arg1Of	transactivator,(
R1999	T2174	T2173	arg2Of	"50,51",(
R2000	T2175	T2173	arg3Of	),(
R2001	T2178	T2176	arg2Of	study,In
R2002	T2178	T2177	arg1Of	study,this
R2003	T2187	T2185	arg1Of	turn,the
R2004	T2180	T2181	arg1Of	we,report
R2005	T2187	T2186	arg1Of	turn,post-activation
R2006	T2181	T2176	arg1Of	report,In
R2007	T2181	T2179	arg1Of	report,","
R2008	T2183	T2184	arg1Of	Tat,counteracts
R2009	T2188	T2189	arg1Of	off,of
R2010	T2184	T2181	arg2Of	counteracts,report
R2011	T2184	T2182	arg1Of	counteracts,that
R2012	T2184	T2188	arg1Of	counteracts,off
R2013	T2184	T2191	arg1Of	counteracts,through
R2014	T2190	T2189	arg2Of	NF-κB,of
R2015	T2193	T2191	arg2Of	interaction,through
R2016	T2193	T2192	arg1Of	interaction,direct
R2017	T2193	T2194	arg1Of	interaction,with
R2018	T2193	T2198	arg1Of	interaction,","
R2019	T2193	T2199	arg1Of	interaction,which
R2020	T2193	T2200	arg1Of	interaction,enhances
R2021	T2195	T2196	arg1Of	IκB-α,and
R2028	T2196	T2194	arg2Of	and,with
R2029	T2197	T2196	arg2Of	p65,and
R2033	T2203	T2202	arg1Of	binding,DNA
R2035	T2203	T2204	arg1Of	binding,and
R2036	T2205	T2204	arg2Of	transcriptional,and
R2037	T2206	T2200	arg2Of	activity,enhances
R2038	T2206	T2201	arg1Of	activity,the
R2039	T2206	T2203	arg1Of	activity,binding
R2040	T2206	T2205	arg1Of	activity,transcriptional
R2041	T2206	T2207	arg1Of	activity,of
R2042	T2210	T2207	arg2Of	complex,of
R2043	T2210	T2208	arg1Of	complex,the
R2044	T2210	T2209	arg1Of	complex,NF-κB
R2045	T2213	T2211	arg1Of	mechanism,The
R2046	T2213	T2212	arg1Of	mechanism,new
R2047	T2213	T2214	arg1Of	mechanism,of
R2048	T2213	T2219	arg1Of	mechanism,may
R2049	T2213	T2220	arg1Of	mechanism,provide
R2050	T2216	T2214	arg2Of	deregulation,of
R2051	T2216	T2215	arg1Of	deregulation,NF-κB
R2052	T2216	T2217	arg1Of	deregulation,here
R2053	T2216	T2218	arg2Of	deregulation,described
R2054	T2220	T2219	arg2Of	provide,may
R2055	T2220	T2223	arg1Of	provide,into
R2056	T2222	T2220	arg2Of	insights,provide
R2057	T2222	T2221	arg1Of	insights,further
R2058	T2227	T2223	arg2Of	activation,into
R2059	T2227	T2224	arg1Of	activation,the
R2060	T2227	T2225	arg1Of	activation,chronic
R2061	T2227	T2226	arg1Of	activation,immune
R2062	T2227	T2228	arg1Of	activation,of
R2063	T2230	T2228	arg2Of	infection,of
R2064	T2230	T2229	arg1Of	infection,HIV-1
R1277	T1461	T1460	arg1Of	factors,transcription
R1278	T1461	T1462	arg1Of	factors,regulate
R1283	T1464	T1462	arg2Of	transcription,regulate
R1284	T1464	T1463	arg1Of	transcription,the

bionlp-st-ge-2016-coref

Id	Subject	Object	Predicate	Lexical cue
T2231	3056-3089	Anaphor	denotes	transacting factors and cofactors
T2232	3099-3102	Antecedent	denotes	Sp1
T2233	3109-3114	Antecedent	denotes	TFIID
T2234	3121-3126	Antecedent	denotes	E2F-4
T2235	3133-3139	Antecedent	denotes	C/EBPβ
T2236	3146-3155	Antecedent	denotes	cyclin T1
T2237	3156-3160	Antecedent	denotes	CDK9
T2238	3173-3203	Anaphor	denotes	the histone acetyltransferases
T2239	3204-3208	Antecedent	denotes	p300
T2240	3209-3212	Antecedent	denotes	CBP
T2241	3217-3222	Antecedent	denotes	P/CAF
T2242	4243-4248	Anaphor	denotes	which
T2243	4211-4222	Antecedent	denotes	interaction
R2022	T2231	T2232	boundBy	transacting factors and cofactors,Sp1
R2023	T2231	T2233	boundBy	transacting factors and cofactors,TFIID
R2024	T2231	T2234	boundBy	transacting factors and cofactors,E2F-4
R2025	T2231	T2235	boundBy	transacting factors and cofactors,C/EBPβ
R2026	T2231	T2236	boundBy	transacting factors and cofactors,cyclin T1
R2027	T2231	T2237	boundBy	transacting factors and cofactors,CDK9
R2030	T2238	T2239	boundBy	the histone acetyltransferases,p300
R2031	T2238	T2240	boundBy	the histone acetyltransferases,CBP
R2032	T2238	T2241	boundBy	the histone acetyltransferases,P/CAF
R2034	T2242	T2243	boundBy	which,interaction

bionlp-st-ge-2016-spacy-parsed

Id	Subject	Object	Predicate	Lexical cue
T2329	13-20	NNP	denotes	Nuclear
T2330	21-27	NN	denotes	factor
T2331	28-29	-LRB-	denotes	(
T2332	29-31	NNP	denotes	NF
T2333	31-32	-RRB-	denotes	)
T2334	32-33	:	denotes	-
T2335	33-35	NN	denotes	κB
T2336	36-49	NN	denotes	transcription
T2337	50-57	NNS	denotes	factors
T2338	58-66	VB	denotes	regulate
T2339	67-70	DT	denotes	the
T2340	71-84	NN	denotes	transcription
T2341	85-87	IN	denotes	of
T2342	88-93	NNS	denotes	genes
T2343	94-98	WDT	denotes	that
T2344	99-102	VBP	denotes	are
T2345	103-111	VBN	denotes	involved
T2346	112-114	IN	denotes	in
T2347	115-118	DT	denotes	the
T2348	119-125	JJ	denotes	immune
T2349	126-129	CC	denotes	and
T2350	130-142	JJ	denotes	inflammatory
T2351	143-151	NN	denotes	response
T2352	152-153	-LRB-	denotes	(
T2353	153-154	CD	denotes	1
T2354	154-155	-RRB-	denotes	)
T2355	155-156	.	denotes	.
T2356	157-160	DT	denotes	The
T2357	161-166	NNP	denotes	NF-κB
T2358	167-173	NN	denotes	family
T2359	174-182	VBZ	denotes	includes
T2360	183-191	NNS	denotes	RelA/p65
T2361	191-192	,	denotes	,
T2362	193-198	NNP	denotes	c-Rel
T2363	198-199	,	denotes	,
T2364	200-204	NNP	denotes	RelB
T2365	204-205	,	denotes	,
T2366	206-209	CD	denotes	p50
T2367	210-213	CC	denotes	and
T2368	214-217	CD	denotes	p52
T2369	218-222	WDT	denotes	that
T2370	223-228	VBP	denotes	share
T2371	229-230	DT	denotes	a
T2372	231-237	RB	denotes	highly
T2373	238-247	VBN	denotes	conserved
T2374	248-257	JJ	denotes	300-amino
T2375	258-262	NN	denotes	acid
T2376	263-266	NNP	denotes	Rel
T2377	267-275	NN	denotes	homology
T2378	276-282	NN	denotes	domain
T2379	283-284	-LRB-	denotes	(
T2380	284-287	NNP	denotes	RHD
T2381	287-288	-RRB-	denotes	)
T2382	289-292	IN	denotes	for
T2383	293-297	NN	denotes	homo
T2384	297-298	:	denotes	-
T2385	299-301	CC	denotes	or
T2386	302-321	NN	denotes	hetero-dimerization
T2387	322-325	CC	denotes	and
T2388	326-337	JJ	denotes	DNA-binding
T2389	337-338	.	denotes	.
T2390	339-342	DT	denotes	The
T2391	343-358	JJ	denotes	transcriptional
T2392	359-367	NN	denotes	activity
T2393	368-370	IN	denotes	of
T2394	371-374	DT	denotes	the
T2395	375-380	JJ	denotes	NF-κB
T2396	381-388	JJ	denotes	complex
T2397	389-396	VBZ	denotes	depends
T2398	397-399	IN	denotes	on
T2399	400-405	NN	denotes	dimer
T2400	406-417	NN	denotes	composition
T2401	418-423	IN	denotes	since
T2402	424-434	JJ	denotes	C-terminal
T2403	435-444	JJ	denotes	unrelated
T2404	445-460	JJ	denotes	transcriptional
T2405	461-471	NN	denotes	activation
T2406	472-479	NNS	denotes	domains
T2407	480-483	VBP	denotes	are
T2408	484-491	JJ	denotes	present
T2409	492-503	RB	denotes	exclusively
T2410	504-506	IN	denotes	in
T2411	507-510	CD	denotes	p65
T2412	510-511	,	denotes	,
T2413	512-516	NNP	denotes	RelB
T2414	517-520	CC	denotes	and
T2415	521-526	NNP	denotes	c-Rel
T2416	527-528	-LRB-	denotes	(
T2417	528-529	LS	denotes	2
T2418	529-530	-RRB-	denotes	)
T2419	530-531	.	denotes	.
T2420	532-542	NNS	denotes	Inhibitors
T2421	543-545	IN	denotes	of
T2422	546-551	NNP	denotes	NF-κB
T2423	552-553	-LRB-	denotes	(
T2424	553-556	NNP	denotes	IκB
T2425	556-557	-RRB-	denotes	)
T2426	558-567	NN	denotes	associate
T2427	568-572	IN	denotes	with
T2428	573-576	DT	denotes	the
T2429	577-582	NNP	denotes	NF-κB
T2430	583-590	NN	denotes	complex
T2431	591-594	CC	denotes	and
T2432	595-604	VB	denotes	interfere
T2433	605-609	IN	denotes	with
T2434	610-613	PRP$	denotes	its
T2435	614-621	JJ	denotes	binding
T2436	622-624	TO	denotes	to
T2437	625-628	NNP	denotes	DNA
T2438	629-630	-LRB-	denotes	(
T2439	630-631	LS	denotes	3
T2440	631-632	-RRB-	denotes	)
T2441	632-633	.	denotes	.
T2442	634-636	IN	denotes	In
T2443	637-640	DT	denotes	the
T2444	641-650	JJ	denotes	canonical
T2445	651-658	NN	denotes	pathway
T2446	659-661	IN	denotes	of
T2447	662-667	JJ	denotes	NF-κB
T2448	668-678	NN	denotes	activation
T2449	678-679	,	denotes	,
T2450	680-683	DT	denotes	the
T2451	684-693	VBN	denotes	activated
T2452	694-697	NNP	denotes	IκB
T2453	698-704	NN	denotes	kinase
T2454	705-706	-LRB-	denotes	(
T2455	706-709	NNP	denotes	IKK
T2456	709-710	-RRB-	denotes	)
T2457	711-725	VBZ	denotes	phosphorylates
T2458	726-729	NNP	denotes	IκB
T2459	730-732	IN	denotes	at
T2460	733-741	JJ	denotes	specific
T2461	742-748	NN	denotes	serine
T2462	749-757	NNS	denotes	residues
T2463	758-762	WDT	denotes	that
T2464	763-769	VBP	denotes	target
T2465	770-773	DT	denotes	the
T2466	774-781	NN	denotes	protein
T2467	782-784	TO	denotes	to
T2468	785-799	NN	denotes	ubiquitination
T2469	800-803	CC	denotes	and
T2470	804-815	JJ	denotes	proteasomal
T2471	816-827	NN	denotes	degradation
T2472	827-828	,	denotes	,
T2473	829-834	WDT	denotes	which
T2474	835-843	VBZ	denotes	releases
T2475	844-847	DT	denotes	the
T2476	848-858	JJ	denotes	functional
T2477	859-864	NN	denotes	NF-κB
T2478	865-872	NN	denotes	complex
T2479	873-875	IN	denotes	in
T2480	876-879	DT	denotes	the
T2481	880-887	NN	denotes	nucleus
T2482	887-888	.	denotes	.
T2483	889-894	NNP	denotes	IκB-α
T2484	894-895	,	denotes	,
T2485	896-899	DT	denotes	the
T2486	900-904	RBS	denotes	most
T2487	905-913	JJ	denotes	abundant
T2488	914-923	NN	denotes	inhibitor
T2489	924-926	IN	denotes	of
T2490	927-932	NNP	denotes	NF-κB
T2491	933-934	-LRB-	denotes	(
T2492	934-935	LS	denotes	4
T2493	935-936	-RRB-	denotes	)
T2494	936-937	,	denotes	,
T2495	938-940	VBZ	denotes	is
T2496	941-955	VBN	denotes	phosphorylated
T2497	956-958	IN	denotes	by
T2498	959-962	NNP	denotes	IKK
T2499	963-965	IN	denotes	at
T2500	966-971	NNP	denotes	Ser32
T2501	972-975	CC	denotes	and
T2502	976-981	NNP	denotes	Ser36
T2503	982-983	-LRB-	denotes	(
T2504	983-984	CD	denotes	5
T2505	984-985	-RRB-	denotes	)
T2506	985-986	,	denotes	,
T2507	987-990	CC	denotes	and
T2508	991-1003	RB	denotes	subsequently
T2509	1004-1017	VBD	denotes	ubiquitylated
T2510	1018-1020	IN	denotes	at
T2511	1021-1026	NNP	denotes	Lys21
T2512	1027-1030	CC	denotes	and
T2513	1031-1036	NNP	denotes	Lys22
T2514	1037-1039	TO	denotes	to
T2515	1040-1042	VB	denotes	be
T2516	1043-1051	JJ	denotes	degraded
T2517	1052-1054	IN	denotes	by
T2518	1055-1058	DT	denotes	the
T2519	1059-1062	JJ	denotes	26S
T2520	1063-1073	JJ	denotes	proteasome
T2521	1074-1075	-LRB-	denotes	(
T2522	1075-1076	CD	denotes	6
T2523	1076-1077	-RRB-	denotes	)
T2524	1077-1078	.	denotes	.
T2525	1079-1082	DT	denotes	The
T2526	1083-1088	JJ	denotes	NF-κB
T2527	1089-1097	NN	denotes	activity
T2528	1098-1100	VBZ	denotes	is
T2529	1101-1109	VBN	denotes	enhanced
T2530	1110-1112	IN	denotes	by
T2531	1113-1128	NN	denotes	phosphorylation
T2532	1129-1131	IN	denotes	of
T2533	1132-1135	CD	denotes	p65
T2534	1136-1138	IN	denotes	at
T2535	1139-1145	CD	denotes	Ser276
T2536	1146-1148	IN	denotes	by
T2537	1149-1152	NNP	denotes	PKA
T2538	1153-1156	CC	denotes	and
T2539	1157-1161	NNP	denotes	MSK1
T2540	1162-1163	-LRB-	denotes	(
T2541	1163-1166	CD	denotes	7,8
T2542	1166-1167	-RRB-	denotes	)
T2543	1167-1168	,	denotes	,
T2544	1169-1175	NNP	denotes	Ser311
T2545	1176-1178	IN	denotes	by
T2546	1179-1183	NNP	denotes	PKCζ
T2547	1184-1185	-LRB-	denotes	(
T2548	1185-1186	CD	denotes	9
T2549	1186-1187	-RRB-	denotes	)
T2550	1188-1191	CC	denotes	and
T2551	1192-1198	NNP	denotes	Ser536
T2552	1199-1201	IN	denotes	by
T2553	1202-1206	NNP	denotes	IKKα
T2554	1207-1208	-LRB-	denotes	(
T2555	1208-1213	CD	denotes	10,11
T2556	1213-1214	-RRB-	denotes	)
T2557	1214-1215	.	denotes	.
T2558	1216-1227	NNP	denotes	Acetylation
T2559	1228-1230	IN	denotes	of
T2560	1231-1234	CD	denotes	p65
T2561	1235-1237	IN	denotes	at
T2562	1238-1244	NNP	denotes	Lys218
T2563	1245-1248	CC	denotes	and
T2564	1249-1255	NNP	denotes	Lys221
T2565	1256-1265	VBZ	denotes	increases
T2566	1266-1269	DT	denotes	the
T2567	1270-1273	NNP	denotes	DNA
T2568	1274-1281	JJ	denotes	binding
T2569	1282-1285	CC	denotes	and
T2570	1286-1293	VBZ	denotes	impairs
T2571	1294-1297	DT	denotes	the
T2572	1298-1309	NN	denotes	association
T2573	1310-1314	IN	denotes	with
T2574	1315-1320	NNP	denotes	IκB-α
T2575	1320-1321	,	denotes	,
T2576	1322-1325	CC	denotes	and
T2577	1326-1337	NN	denotes	acetylation
T2578	1338-1340	IN	denotes	at
T2579	1341-1347	NNP	denotes	Lys310
T2580	1348-1356	VBZ	denotes	enhances
T2581	1357-1360	DT	denotes	the
T2582	1361-1364	CD	denotes	p65
T2583	1365-1380	JJ	denotes	transcriptional
T2584	1381-1389	NN	denotes	activity
T2585	1390-1391	-LRB-	denotes	(
T2586	1391-1396	CD	denotes	12,13
T2587	1396-1397	-RRB-	denotes	)
T2588	1397-1398	.	denotes	.
T2589	1399-1414	NN	denotes	Post-activation
T2590	1415-1419	VB	denotes	turn
T2591	1420-1423	RB	denotes	off
T2592	1424-1426	IN	denotes	of
T2593	1427-1432	NN	denotes	NF-κB
T2594	1433-1435	VBZ	denotes	is
T2595	1436-1445	VBN	denotes	regulated
T2596	1446-1448	IN	denotes	by
T2597	1449-1457	JJ	denotes	negative
T2598	1458-1466	NN	denotes	feedback
T2599	1467-1471	NN	denotes	loop
T2600	1472-1479	IN	denotes	through
T2601	1480-1490	NNS	denotes	inhibitors
T2602	1491-1496	IN	denotes	under
T2603	1497-1500	DT	denotes	the
T2604	1501-1516	JJ	denotes	transcriptional
T2605	1517-1524	NN	denotes	control
T2606	1525-1527	IN	denotes	of
T2607	1528-1533	NNP	denotes	NF-κB
T2608	1533-1534	,	denotes	,
T2609	1535-1539	JJ	denotes	such
T2610	1540-1542	IN	denotes	as
T2611	1543-1548	JJ	denotes	IκB-α
T2612	1549-1552	CC	denotes	and
T2613	1553-1570	JJ	denotes	ubiquitin-editing
T2614	1571-1578	NN	denotes	protein
T2615	1579-1582	NNP	denotes	A20
T2616	1583-1584	-LRB-	denotes	(
T2617	1584-1586	CD	denotes	14
T2618	1587-1589	CD	denotes	20
T2619	1589-1590	-RRB-	denotes	)
T2620	1590-1591	.	denotes	.
T2621	1592-1605	NN	denotes	Deacetylation
T2622	1606-1608	IN	denotes	of
T2623	1609-1612	CD	denotes	p65
T2624	1613-1615	IN	denotes	by
T2625	1616-1623	NN	denotes	histone
T2626	1624-1637	JJ	denotes	deacetylase-3
T2627	1638-1640	CC	denotes	or
T2628	1641-1646	CD	denotes	SIRT1
T2629	1646-1647	,	denotes	,
T2630	1648-1650	CC	denotes	or
T2631	1651-1662	NN	denotes	acetylation
T2632	1663-1665	IN	denotes	of
T2633	1666-1669	NNS	denotes	p65
T2634	1670-1672	IN	denotes	at
T2635	1673-1679	NNP	denotes	Lys122
T2636	1680-1683	CC	denotes	and
T2637	1684-1690	NNP	denotes	Lys123
T2638	1691-1704	VBP	denotes	down-regulate
T2639	1705-1708	DT	denotes	the
T2640	1709-1714	NN	denotes	NF-κB
T2641	1715-1723	NN	denotes	activity
T2642	1724-1725	-LRB-	denotes	(
T2643	1725-1733	CD	denotes	12,21,22
T2644	1733-1734	-RRB-	denotes	)
T2645	1734-1735	.	denotes	.
T2646	1736-1746	JJ	denotes	Persistent
T2647	1747-1757	NN	denotes	activation
T2648	1758-1760	IN	denotes	of
T2649	1761-1766	JJ	denotes	NF-κB
T2650	1767-1773	VBZ	denotes	occurs
T2651	1774-1776	IN	denotes	in
T2652	1777-1782	JJ	denotes	human
T2653	1783-1799	NN	denotes	immunodeficiency
T2654	1800-1807	JJ	denotes	virus-1
T2655	1808-1809	-LRB-	denotes	(
T2656	1809-1814	NNP	denotes	HIV-1
T2657	1814-1815	-RRB-	denotes	)
T2658	1815-1816	:	denotes	-
T2659	1816-1824	VBN	denotes	infected
T2660	1825-1834	NNS	denotes	monocytes
T2661	1834-1835	,	denotes	,
T2662	1836-1847	NNS	denotes	macrophages
T2663	1848-1851	CC	denotes	and
T2664	1852-1861	NNS	denotes	microglia
T2665	1861-1862	,	denotes	,
T2666	1863-1866	CC	denotes	and
T2667	1867-1875	VBZ	denotes	enhances
T2668	1876-1879	DT	denotes	the
T2669	1880-1890	NN	denotes	expression
T2670	1891-1893	IN	denotes	of
T2671	1894-1910	JJ	denotes	NF-κB-responsive
T2672	1911-1916	NNS	denotes	genes
T2673	1916-1917	,	denotes	,
T2674	1918-1927	VBG	denotes	including
T2675	1928-1944	JJ	denotes	pro-inflammatory
T2676	1945-1954	NNS	denotes	cytokines
T2677	1954-1955	,	denotes	,
T2678	1956-1960	NN	denotes	cell
T2679	1961-1969	NN	denotes	adhesion
T2680	1970-1979	NNS	denotes	molecules
T2681	1980-1983	CC	denotes	and
T2682	1984-1994	NNS	denotes	chemokines
T2683	1995-1996	-LRB-	denotes	(
T2684	1996-1998	CD	denotes	23
T2685	1999-2001	CD	denotes	25
T2686	2001-2002	-RRB-	denotes	)
T2687	2002-2003	.	denotes	.
T2688	2004-2011	JJ	denotes	Chronic
T2689	2012-2024	NN	denotes	inflammation
T2690	2025-2027	VBZ	denotes	is
T2691	2028-2029	DT	denotes	a
T2692	2030-2035	JJ	denotes	major
T2693	2036-2041	NN	denotes	cause
T2694	2042-2044	IN	denotes	of
T2695	2045-2051	JJ	denotes	immune
T2696	2052-2055	CC	denotes	and
T2697	2056-2062	JJ	denotes	neuron
T2698	2063-2074	NN	denotes	dysfunction
T2699	2075-2077	IN	denotes	in
T2700	2078-2082	NNP	denotes	AIDS
T2701	2083-2084	-LRB-	denotes	(
T2702	2084-2089	CD	denotes	26,27
T2703	2089-2090	-RRB-	denotes	)
T2704	2090-2091	.	denotes	.
T2705	2092-2104	RB	denotes	Consistently
T2706	2104-2105	,	denotes	,
T2707	2106-2115	JJ	denotes	non-human
T2708	2116-2123	NN	denotes	primate
T2709	2124-2129	NNS	denotes	hosts
T2710	2130-2133	IN	denotes	for
T2711	2134-2140	JJ	denotes	simian
T2712	2141-2157	NN	denotes	immunodeficiency
T2713	2158-2163	NN	denotes	virus
T2714	2163-2164	,	denotes	,
T2715	2165-2169	JJ	denotes	such
T2716	2170-2172	IN	denotes	as
T2717	2173-2180	JJ	denotes	African
T2718	2181-2186	JJ	denotes	green
T2719	2187-2194	NNS	denotes	monkeys
T2720	2195-2198	CC	denotes	and
T2721	2199-2204	JJ	denotes	sooty
T2722	2205-2213	NN	denotes	mangabey
T2723	2213-2214	,	denotes	,
T2724	2215-2219	VBP	denotes	lack
T2725	2220-2228	JJ	denotes	aberrant
T2726	2229-2235	JJ	denotes	immune
T2727	2236-2246	NN	denotes	activation
T2728	2247-2250	CC	denotes	and
T2729	2251-2253	VB	denotes	do
T2730	2254-2257	RB	denotes	not
T2731	2258-2265	VB	denotes	develop
T2732	2266-2270	NNP	denotes	AIDS
T2733	2271-2278	IN	denotes	despite
T2734	2279-2283	JJ	denotes	high
T2735	2284-2289	NN	denotes	virus
T2736	2290-2301	NN	denotes	replication
T2737	2302-2303	-LRB-	denotes	(
T2738	2303-2308	CD	denotes	28,29
T2739	2308-2309	-RRB-	denotes	)
T2740	2309-2310	.	denotes	.
T2741	2311-2315	RB	denotes	Thus
T2742	2315-2316	,	denotes	,
T2743	2317-2330	VBG	denotes	understanding
T2744	2331-2334	DT	denotes	the
T2745	2335-2345	NNS	denotes	mechanisms
T2746	2346-2348	IN	denotes	of
T2747	2349-2354	JJ	denotes	NF-κB
T2748	2355-2367	NN	denotes	deregulation
T2749	2368-2370	IN	denotes	by
T2750	2371-2376	NNP	denotes	HIV-1
T2751	2377-2380	MD	denotes	may
T2752	2381-2388	VB	denotes	provide
T2753	2389-2396	JJ	denotes	further
T2754	2397-2405	NNS	denotes	insights
T2755	2406-2410	IN	denotes	into
T2756	2411-2415	NNP	denotes	AIDS
T2757	2416-2428	NN	denotes	pathogenesis
T2758	2428-2429	.	denotes	.
T2759	2430-2432	IN	denotes	In
T2760	2433-2438	JJ	denotes	HIV-1
T2761	2439-2444	NN	denotes	entry
T2762	2444-2445	,	denotes	,
T2763	2446-2449	DT	denotes	the
T2764	2450-2457	JJ	denotes	binding
T2765	2458-2460	IN	denotes	of
T2766	2461-2464	DT	denotes	the
T2767	2465-2470	NNS	denotes	gp120
T2768	2471-2476	JJ	denotes	viral
T2769	2477-2485	NN	denotes	envelope
T2770	2486-2488	TO	denotes	to
T2771	2489-2492	CD	denotes	CD4
T2772	2493-2500	VBZ	denotes	induces
T2773	2501-2504	DT	denotes	the
T2774	2505-2510	JJ	denotes	NF-κB
T2775	2511-2519	NN	denotes	activity
T2776	2520-2522	IN	denotes	by
T2777	2523-2533	NN	denotes	activation
T2778	2534-2536	IN	denotes	of
T2779	2537-2540	NNP	denotes	IKK
T2780	2541-2542	-LRB-	denotes	(
T2781	2542-2544	CD	denotes	30
T2782	2544-2545	-RRB-	denotes	)
T2783	2546-2549	CC	denotes	and
T2784	2550-2560	NN	denotes	procaspase
T2785	2561-2562	CD	denotes	8
T2786	2563-2564	-LRB-	denotes	(
T2787	2564-2566	CD	denotes	31
T2788	2566-2567	-RRB-	denotes	)
T2789	2567-2568	.	denotes	.
T2790	2569-2578	VBG	denotes	Following
T2791	2579-2584	JJ	denotes	viral
T2792	2585-2596	NN	denotes	integration
T2793	2596-2597	,	denotes	,
T2794	2598-2601	DT	denotes	the
T2795	2602-2607	JJ	denotes	early
T2796	2608-2615	JJ	denotes	encoded
T2797	2616-2621	NNP	denotes	HIV-1
T2798	2622-2625	NNP	denotes	Tat
T2799	2626-2633	NN	denotes	protein
T2800	2634-2643	NNS	denotes	interacts
T2801	2644-2648	IN	denotes	with
T2802	2649-2652	DT	denotes	the
T2803	2653-2658	NNP	denotes	HIV-1
T2804	2659-2662	NNP	denotes	RNA
T2805	2663-2666	CC	denotes	and
T2806	2667-2671	NN	denotes	host
T2807	2672-2676	NN	denotes	cell
T2808	2677-2684	NNS	denotes	factors
T2809	2685-2687	TO	denotes	to
T2810	2688-2695	VB	denotes	sustain
T2811	2696-2699	DT	denotes	the
T2812	2700-2705	JJ	denotes	viral
T2813	2706-2717	NN	denotes	replication
T2814	2717-2718	.	denotes	.
T2815	2719-2722	NNP	denotes	Tat
T2816	2723-2728	VBZ	denotes	binds
T2817	2729-2731	TO	denotes	to
T2818	2732-2735	NNP	denotes	RNA
T2819	2736-2745	JJ	denotes	stem-loop
T2820	2746-2756	NNS	denotes	structures
T2821	2757-2766	VBN	denotes	generated
T2822	2767-2769	IN	denotes	by
T2823	2770-2773	DT	denotes	the
T2824	2774-2775	CD	denotes	5
T2825	2775-2776	NN	denotes	′
T2826	2777-2780	NN	denotes	end
T2827	2781-2783	IN	denotes	of
T2828	2784-2790	NN	denotes	target
T2829	2791-2802	NNS	denotes	transcripts
T2830	2802-2803	,	denotes	,
T2831	2804-2813	VBG	denotes	including
T2832	2814-2817	DT	denotes	the
T2833	2818-2823	NNP	denotes	HIV-1
T2834	2824-2850	JJ	denotes	transactivation-responsive
T2835	2851-2858	NN	denotes	element
T2836	2859-2860	-LRB-	denotes	(
T2837	2860-2863	NNP	denotes	TAR
T2838	2863-2864	-RRB-	denotes	)
T2839	2865-2866	-LRB-	denotes	(
T2840	2866-2868	CD	denotes	32
T2841	2868-2869	-RRB-	denotes	)
T2842	2869-2870	,	denotes	,
T2843	2871-2876	NN	denotes	tumor
T2844	2877-2885	NN	denotes	necrosis
T2845	2886-2892	NN	denotes	factor
T2846	2893-2894	NN	denotes	β
T2847	2895-2896	-LRB-	denotes	(
T2848	2896-2900	NNP	denotes	TNFβ
T2849	2900-2901	-RRB-	denotes	)
T2850	2902-2903	-LRB-	denotes	(
T2851	2903-2905	CD	denotes	33
T2852	2905-2906	-RRB-	denotes	)
T2853	2907-2910	CC	denotes	and
T2854	2911-2924	JJ	denotes	interleukin-6
T2855	2925-2926	-LRB-	denotes	(
T2856	2926-2930	NN	denotes	IL-6
T2857	2930-2931	-RRB-	denotes	)
T2858	2932-2933	-LRB-	denotes	(
T2859	2933-2935	CD	denotes	34
T2860	2935-2936	-RRB-	denotes	)
T2861	2937-2939	TO	denotes	to
T2862	2940-2948	VB	denotes	activate
T2863	2949-2953	NN	denotes	gene
T2864	2954-2967	NN	denotes	transcription
T2865	2967-2968	.	denotes	.
T2866	2969-2975	RB	denotes	Indeed
T2867	2975-2976	,	denotes	,
T2868	2977-2980	NNP	denotes	Tat
T2869	2981-2989	VBZ	denotes	promotes
T2870	2990-2993	DT	denotes	the
T2871	2994-3009	JJ	denotes	transcriptional
T2872	3010-3020	NN	denotes	initiation
T2873	3021-3024	CC	denotes	and
T2874	3025-3035	NN	denotes	elongation
T2875	3036-3038	IN	denotes	by
T2876	3039-3050	VBG	denotes	interacting
T2877	3051-3055	IN	denotes	with
T2878	3056-3067	VBG	denotes	transacting
T2879	3068-3075	NNS	denotes	factors
T2880	3076-3079	CC	denotes	and
T2881	3080-3089	NNS	denotes	cofactors
T2882	3089-3090	,	denotes	,
T2883	3091-3095	JJ	denotes	such
T2884	3096-3098	IN	denotes	as
T2885	3099-3102	NNP	denotes	Sp1
T2886	3103-3104	-LRB-	denotes	(
T2887	3104-3106	CD	denotes	35
T2888	3106-3107	-RRB-	denotes	)
T2889	3107-3108	,	denotes	,
T2890	3109-3114	NNP	denotes	TFIID
T2891	3115-3116	-LRB-	denotes	(
T2892	3116-3118	CD	denotes	36
T2893	3118-3119	-RRB-	denotes	)
T2894	3119-3120	,	denotes	,
T2895	3121-3126	NNP	denotes	E2F-4
T2896	3127-3128	-LRB-	denotes	(
T2897	3128-3130	CD	denotes	37
T2898	3130-3131	-RRB-	denotes	)
T2899	3131-3132	,	denotes	,
T2900	3133-3138	NNP	denotes	C/EBP
T2901	3138-3139	NNP	denotes	β
T2902	3140-3141	-LRB-	denotes	(
T2903	3141-3143	CD	denotes	38
T2904	3143-3144	-RRB-	denotes	)
T2905	3144-3145	,	denotes	,
T2906	3146-3152	NN	denotes	cyclin
T2907	3153-3160	CD	denotes	T1/CDK9
T2908	3161-3162	-LRB-	denotes	(
T2909	3162-3167	CD	denotes	39,40
T2910	3167-3168	-RRB-	denotes	)
T2911	3169-3172	CC	denotes	and
T2912	3173-3176	DT	denotes	the
T2913	3177-3184	NN	denotes	histone
T2914	3185-3203	VBZ	denotes	acetyltransferases
T2915	3204-3212	NNP	denotes	p300/CBP
T2916	3213-3216	CC	denotes	and
T2917	3217-3222	NNP	denotes	P/CAF
T2918	3223-3224	-LRB-	denotes	(
T2919	3224-3226	CD	denotes	41
T2920	3227-3229	CD	denotes	43
T2921	3229-3230	-RRB-	denotes	)
T2922	3230-3231	.	denotes	.
T2923	3232-3236	WRB	denotes	When
T2924	3237-3245	VBN	denotes	released
T2925	3246-3250	IN	denotes	from
T2926	3251-3265	JJ	denotes	HIV-1-infected
T2927	3266-3271	NNS	denotes	cells
T2928	3271-3272	,	denotes	,
T2929	3273-3276	NNP	denotes	Tat
T2930	3277-3288	VBZ	denotes	deregulates
T2931	3289-3292	DT	denotes	the
T2932	3293-3297	NN	denotes	cell
T2933	3298-3307	VBG	denotes	signaling
T2934	3308-3310	IN	denotes	by
T2935	3311-3318	JJ	denotes	binding
T2936	3319-3321	TO	denotes	to
T2937	3322-3326	NN	denotes	cell
T2938	3327-3336	NNS	denotes	receptors
T2939	3336-3337	,	denotes	,
T2940	3338-3342	JJ	denotes	such
T2941	3343-3345	IN	denotes	as
T2942	3346-3355	NNS	denotes	integrins
T2943	3356-3357	-LRB-	denotes	(
T2944	3357-3359	CD	denotes	44
T2945	3359-3360	-RRB-	denotes	)
T2946	3360-3361	,	denotes	,
T2947	3362-3370	NN	denotes	Flk1/KDR
T2948	3371-3379	NN	denotes	receptor
T2949	3380-3381	-LRB-	denotes	(
T2950	3381-3383	CD	denotes	45
T2951	3383-3384	-RRB-	denotes	)
T2952	3385-3388	CC	denotes	and
T2953	3389-3398	JJ	denotes	chemokine
T2954	3399-3408	NNS	denotes	receptors
T2955	3409-3410	-LRB-	denotes	(
T2956	3410-3412	CD	denotes	46
T2957	3412-3413	-RRB-	denotes	)
T2958	3413-3414	.	denotes	.
T2959	3415-3417	PRP	denotes	We
T2960	3418-3423	RB	denotes	first
T2961	3424-3432	VBD	denotes	reported
T2962	3433-3437	IN	denotes	that
T2963	3438-3443	NNP	denotes	NF-κB
T2964	3444-3447	VBD	denotes	was
T2965	3448-3462	RB	denotes	constitutively
T2966	3463-3469	JJ	denotes	active
T2967	3470-3472	IN	denotes	in
T2968	3473-3479	NNP	denotes	Jurkat
T2969	3480-3485	NNS	denotes	cells
T2970	3486-3490	WDT	denotes	that
T2971	3491-3497	RB	denotes	stably
T2972	3498-3507	VBD	denotes	expressed
T2973	3508-3511	DT	denotes	the
T2974	3512-3515	NNP	denotes	Tat
T2975	3516-3520	NN	denotes	gene
T2976	3521-3522	-LRB-	denotes	(
T2977	3522-3524	CD	denotes	47
T2978	3524-3525	-RRB-	denotes	)
T2979	3525-3526	.	denotes	.
T2980	3527-3536	VBG	denotes	Following
T2981	3537-3541	NN	denotes	gene
T2982	3542-3554	NN	denotes	transfection
T2983	3555-3557	CC	denotes	or
T2984	3558-3565	NN	denotes	protein
T2985	3566-3578	NN	denotes	transduction
T2986	3578-3579	,	denotes	,
T2987	3580-3583	NNP	denotes	Tat
T2988	3584-3591	VBD	denotes	induced
T2989	3592-3595	DT	denotes	the
T2990	3596-3599	NNP	denotes	IKK
T2991	3600-3608	NN	denotes	activity
T2992	3609-3612	CC	denotes	and
T2993	3613-3624	JJ	denotes	proteasomal
T2994	3625-3636	NN	denotes	degradation
T2995	3637-3639	IN	denotes	of
T2996	3640-3645	NNP	denotes	IκB-α
T2997	3646-3647	-LRB-	denotes	(
T2998	3647-3649	CD	denotes	48
T2999	3649-3650	-RRB-	denotes	)
T3000	3650-3651	,	denotes	,
T3001	3652-3655	CC	denotes	and
T3002	3656-3665	VBD	denotes	increased
T3003	3666-3669	DT	denotes	the
T3004	3670-3673	NNS	denotes	p65
T3005	3674-3689	JJ	denotes	transcriptional
T3006	3690-3698	NN	denotes	activity
T3007	3699-3701	IN	denotes	by
T3008	3702-3712	VBG	denotes	inhibiting
T3009	3713-3716	DT	denotes	the
T3010	3717-3732	JJ	denotes	SIRT-1-mediated
T3011	3733-3746	NN	denotes	deacetylation
T3012	3747-3749	IN	denotes	of
T3013	3750-3753	CD	denotes	p65
T3014	3754-3760	NNP	denotes	Lys310
T3015	3761-3762	-LRB-	denotes	(
T3016	3762-3764	CD	denotes	49
T3017	3764-3765	-RRB-	denotes	)
T3018	3765-3766	.	denotes	.
T3019	3767-3772	DT	denotes	These
T3020	3773-3781	NNS	denotes	findings
T3021	3782-3791	VBD	denotes	suggested
T3022	3792-3796	IN	denotes	that
T3023	3797-3800	NNP	denotes	Tat
T3024	3801-3810	VBZ	denotes	modulates
T3025	3811-3818	JJ	denotes	crucial
T3026	3819-3826	NNS	denotes	enzymes
T3027	3827-3835	VBN	denotes	involved
T3028	3836-3838	IN	denotes	in
T3029	3839-3844	JJ	denotes	NF-κB
T3030	3845-3854	VBG	denotes	signaling
T3031	3854-3855	:	denotes	;
T3032	3856-3863	RB	denotes	however
T3033	3863-3864	,	denotes	,
T3034	3865-3867	PRP	denotes	it
T3035	3868-3871	VBD	denotes	was
T3036	3872-3879	JJ	denotes	unclear
T3037	3880-3883	WRB	denotes	how
T3038	3884-3887	NNP	denotes	Tat
T3039	3888-3893	MD	denotes	could
T3040	3894-3901	VB	denotes	subvert
T3041	3902-3905	DT	denotes	the
T3042	3906-3914	JJ	denotes	negative
T3043	3915-3923	NN	denotes	feedback
T3044	3924-3926	IN	denotes	of
T3045	3927-3932	NNP	denotes	NF-κB
T3046	3932-3933	,	denotes	,
T3047	3934-3939	WDT	denotes	which
T3048	3940-3942	VBZ	denotes	is
T3049	3943-3949	RB	denotes	mainly
T3050	3950-3959	JJ	denotes	dependent
T3051	3960-3962	IN	denotes	on
T3052	3963-3965	FW	denotes	de
T3053	3966-3970	FW	denotes	novo
T3054	3971-3980	NN	denotes	synthesis
T3055	3981-3983	IN	denotes	of
T3056	3984-3989	NNP	denotes	IκB-α
T3057	3990-3991	-LRB-	denotes	(
T3058	3991-3996	CD	denotes	15,17
T3059	3996-3997	-RRB-	denotes	)
T3060	3997-3998	.	denotes	.
T3061	3999-4001	PRP	denotes	We
T3062	4002-4012	RB	denotes	previously
T3063	4013-4018	VBD	denotes	found
T3064	4019-4023	IN	denotes	that
T3065	4024-4029	JJ	denotes	IκB-α
T3066	4030-4035	NNS	denotes	binds
T3067	4036-4038	TO	denotes	to
T3068	4039-4042	NNP	denotes	Tat
T3069	4043-4046	CC	denotes	and
T3070	4047-4055	VBZ	denotes	promotes
T3071	4056-4059	DT	denotes	the
T3072	4060-4067	JJ	denotes	nuclear
T3073	4068-4074	NN	denotes	export
T3074	4075-4077	IN	denotes	of
T3075	4078-4081	DT	denotes	the
T3076	4082-4087	JJ	denotes	viral
T3077	4088-4102	NN	denotes	transactivator
T3078	4103-4104	-LRB-	denotes	(
T3079	4104-4109	CD	denotes	50,51
T3080	4109-4110	-RRB-	denotes	)
T3081	4110-4111	.	denotes	.
T3082	4112-4114	IN	denotes	In
T3083	4115-4119	DT	denotes	this
T3084	4120-4125	NN	denotes	study
T3085	4125-4126	,	denotes	,
T3086	4127-4129	PRP	denotes	we
T3087	4130-4136	VBP	denotes	report
T3088	4137-4141	IN	denotes	that
T3089	4142-4145	NNP	denotes	Tat
T3090	4146-4157	VBZ	denotes	counteracts
T3091	4158-4161	DT	denotes	the
T3092	4162-4177	JJ	denotes	post-activation
T3093	4178-4182	NN	denotes	turn
T3094	4183-4186	IN	denotes	off
T3095	4187-4189	IN	denotes	of
T3096	4190-4195	NN	denotes	NF-κB
T3097	4196-4203	IN	denotes	through
T3098	4204-4210	JJ	denotes	direct
T3099	4211-4222	NN	denotes	interaction
T3100	4223-4227	IN	denotes	with
T3101	4228-4233	NNP	denotes	IκB-α
T3102	4234-4237	CC	denotes	and
T3103	4238-4241	CD	denotes	p65
T3104	4241-4242	,	denotes	,
T3105	4243-4248	WDT	denotes	which
T3106	4249-4257	VBZ	denotes	enhances
T3107	4258-4261	DT	denotes	the
T3108	4262-4265	NNP	denotes	DNA
T3109	4266-4273	JJ	denotes	binding
T3110	4274-4277	CC	denotes	and
T3111	4278-4293	JJ	denotes	transcriptional
T3112	4294-4302	NN	denotes	activity
T3113	4303-4305	IN	denotes	of
T3114	4306-4309	DT	denotes	the
T3115	4310-4315	NNP	denotes	NF-κB
T3116	4316-4323	NN	denotes	complex
T3117	4323-4324	.	denotes	.
T3118	4325-4328	DT	denotes	The
T3119	4329-4332	JJ	denotes	new
T3120	4333-4342	NN	denotes	mechanism
T3121	4343-4345	IN	denotes	of
T3122	4346-4351	JJ	denotes	NF-κB
T3123	4352-4364	NN	denotes	deregulation
T3124	4365-4369	RB	denotes	here
T3125	4370-4379	VBD	denotes	described
T3126	4380-4383	MD	denotes	may
T3127	4384-4391	VB	denotes	provide
T3128	4392-4399	JJ	denotes	further
T3129	4400-4408	NNS	denotes	insights
T3130	4409-4413	IN	denotes	into
T3131	4414-4417	DT	denotes	the
T3132	4418-4425	JJ	denotes	chronic
T3133	4426-4432	JJ	denotes	immune
T3134	4433-4443	NN	denotes	activation
T3135	4444-4446	IN	denotes	of
T3136	4447-4452	JJ	denotes	HIV-1
T3137	4453-4462	NN	denotes	infection
T3138	4462-4463	.	denotes	.
R2065	T2329	T2330	compound	Nuclear,factor
R2066	T2330	T2337	nmod	factor,factors
R2067	T2331	T2332	punct	(,NF
R2068	T2332	T2330	appos	NF,factor
R2069	T2333	T2332	punct	),NF
R2070	T2334	T2335	punct	-,κB
R2071	T2335	T2337	amod	κB,factors
R2072	T2336	T2337	compound	transcription,factors
R2073	T2337	T2338	nsubj	factors,regulate
R2074	T2338	T2338	ROOT	regulate,regulate
R2075	T2339	T2340	det	the,transcription
R2076	T2340	T2338	dobj	transcription,regulate
R2077	T2341	T2340	prep	of,transcription
R2078	T2342	T2341	pobj	genes,of
R2079	T2343	T2345	nsubjpass	that,involved
R2080	T2344	T2345	auxpass	are,involved
R2081	T2377	T2378	compound	homology,domain
R2082	T2345	T2342	relcl	involved,genes
R2083	T2346	T2345	prep	in,involved
R2084	T2378	T2370	dobj	domain,share
R2085	T2347	T2351	det	the,response
R2086	T2348	T2351	amod	immune,response
R2087	T2379	T2380	punct	(,RHD
R2088	T2380	T2378	appos	RHD,domain
R2089	T2349	T2348	cc	and,immune
R2090	T2381	T2360	punct	),RelA/p65
R2091	T2350	T2348	conj	inflammatory,immune
R2092	T2351	T2346	pobj	response,in
R2093	T2352	T2353	punct	(,1
R2094	T2353	T2342	appos	1,genes
R2095	T2382	T2359	prep	for,includes
R2096	T2354	T2353	punct	),1
R2097	T2355	T2338	punct	.,regulate
R2098	T2356	T2358	det	The,family
R2099	T2357	T2358	compound	NF-κB,family
R2100	T2358	T2359	nsubj	family,includes
R2101	T2359	T2359	ROOT	includes,includes
R2102	T2383	T2382	pobj	homo,for
R2103	T2360	T2359	dobj	RelA/p65,includes
R2104	T2361	T2360	punct	",",RelA/p65
R2105	T2362	T2360	conj	c-Rel,RelA/p65
R2106	T2363	T2362	punct	",",c-Rel
R2107	T2384	T2383	punct	-,homo
R2108	T2364	T2362	conj	RelB,c-Rel
R2109	T2365	T2364	punct	",",RelB
R2110	T2366	T2364	conj	p50,RelB
R2111	T2385	T2383	cc	or,homo
R2112	T2367	T2366	cc	and,p50
R2113	T2368	T2366	conj	p52,p50
R2114	T2369	T2370	nsubj	that,share
R2115	T2370	T2368	relcl	share,p52
R2116	T2386	T2383	conj	hetero-dimerization,homo
R2117	T2371	T2378	det	a,domain
R2118	T2372	T2373	advmod	highly,conserved
R2119	T2373	T2378	amod	conserved,domain
R2120	T2374	T2375	amod	300-amino,acid
R2121	T2387	T2386	cc	and,hetero-dimerization
R2122	T2375	T2378	compound	acid,domain
R2123	T2376	T2378	compound	Rel,domain
R2124	T2388	T2386	conj	DNA-binding,hetero-dimerization
R2125	T2389	T2359	punct	.,includes
R2126	T2390	T2392	det	The,activity
R2127	T2391	T2392	amod	transcriptional,activity
R2128	T2392	T2397	nsubj	activity,depends
R2129	T2474	T2471	relcl	releases,degradation
R2130	T2475	T2478	det	the,complex
R2131	T2476	T2478	amod	functional,complex
R2132	T2393	T2392	prep	of,activity
R2133	T2477	T2478	compound	NF-κB,complex
R2134	T2478	T2474	dobj	complex,releases
R2135	T2394	T2397	det	the,depends
R2136	T2479	T2478	prep	in,complex
R2137	T2480	T2481	det	the,nucleus
R2138	T2481	T2479	pobj	nucleus,in
R2139	T2395	T2397	nsubj	NF-κB,depends
R2140	T2482	T2457	punct	.,phosphorylates
R2141	T2483	T2496	nsubjpass	IκB-α,phosphorylated
R2142	T2484	T2483	punct	",",IκB-α
R2143	T2396	T2397	nsubj	complex,depends
R2144	T2485	T2488	det	the,inhibitor
R2145	T2486	T2487	advmod	most,abundant
R2146	T2397	T2397	ROOT	depends,depends
R2147	T2487	T2488	amod	abundant,inhibitor
R2148	T2488	T2483	appos	inhibitor,IκB-α
R2149	T2489	T2488	prep	of,inhibitor
R2150	T2490	T2489	pobj	NF-κB,of
R2151	T2491	T2492	punct	(,4
R2152	T2398	T2397	prep	on,depends
R2153	T2492	T2490	appos	4,NF-κB
R2154	T2399	T2400	amod	dimer,composition
R2155	T2493	T2492	punct	),4
R2156	T2494	T2496	punct	",",phosphorylated
R2157	T2400	T2398	pobj	composition,on
R2158	T2495	T2496	auxpass	is,phosphorylated
R2159	T2496	T2496	ROOT	phosphorylated,phosphorylated
R2160	T2497	T2496	agent	by,phosphorylated
R2161	T2401	T2407	mark	since,are
R2162	T2498	T2497	pobj	IKK,by
R2163	T2499	T2496	prep	at,phosphorylated
R2164	T2402	T2406	amod	C-terminal,domains
R2165	T2500	T2499	pobj	Ser32,at
R2166	T2501	T2500	cc	and,Ser32
R2167	T2502	T2500	conj	Ser36,Ser32
R2168	T2403	T2406	amod	unrelated,domains
R2169	T2503	T2504	punct	(,5
R2170	T2504	T2502	parataxis	5,Ser36
R2171	T2404	T2406	amod	transcriptional,domains
R2172	T2405	T2406	compound	activation,domains
R2173	T2505	T2504	punct	),5
R2174	T2506	T2502	punct	",",Ser36
R2175	T2406	T2407	nsubj	domains,are
R2176	T2507	T2502	cc	and,Ser36
R2177	T2508	T2509	advmod	subsequently,ubiquitylated
R2178	T2509	T2509	ROOT	ubiquitylated,ubiquitylated
R2179	T2407	T2397	advcl	are,depends
R2180	T2510	T2509	prep	at,ubiquitylated
R2181	T2511	T2510	pobj	Lys21,at
R2182	T2512	T2511	cc	and,Lys21
R2183	T2408	T2407	acomp	present,are
R2184	T2513	T2511	conj	Lys22,Lys21
R2185	T2514	T2516	aux	to,degraded
R2186	T2515	T2516	auxpass	be,degraded
R2187	T2409	T2408	advmod	exclusively,present
R2188	T2516	T2509	xcomp	degraded,ubiquitylated
R2189	T2517	T2516	agent	by,degraded
R2190	T2518	T2520	det	the,proteasome
R2191	T2410	T2407	prep	in,are
R2192	T2519	T2520	amod	26S,proteasome
R2193	T2520	T2517	pobj	proteasome,by
R2194	T2521	T2522	punct	(,6
R2195	T2411	T2410	pobj	p65,in
R2196	T2522	T2520	appos	6,proteasome
R2198	T2523	T2520	punct	),proteasome
R2199	T2524	T2496	punct	.,phosphorylated
R2200	T2525	T2527	det	The,activity
R2201	T2526	T2527	amod	NF-κB,activity
R2202	T2527	T2529	nsubjpass	activity,enhanced
R2203	T2528	T2529	auxpass	is,enhanced
R2204	T2529	T2529	ROOT	enhanced,enhanced
R2205	T2530	T2529	agent	by,enhanced
R2206	T2531	T2530	pobj	phosphorylation,by
R2207	T2532	T2531	prep	of,phosphorylation
R2208	T2533	T2532	pobj	p65,of
R2210	T2534	T2529	prep	at,enhanced
R2211	T2535	T2534	pobj	Ser276,at
R2212	T2536	T2529	agent	by,enhanced
R2213	T2537	T2536	pobj	PKA,by
R2215	T2538	T2537	cc	and,PKA
R2216	T2539	T2537	conj	MSK1,PKA
R2217	T2540	T2539	punct	(,MSK1
R2219	T2541	T2539	parataxis	"7,8",MSK1
R2220	T2542	T2539	punct	),MSK1
R2221	T2543	T2537	punct	",",PKA
R2223	T2544	T2537	conj	Ser311,PKA
R2224	T2545	T2529	agent	by,enhanced
R2225	T2546	T2545	pobj	PKCζ,by
R2227	T2547	T2548	punct	(,9
R2228	T2548	T2546	parataxis	9,PKCζ
R2229	T2549	T2548	punct	),9
R2231	T2550	T2546	cc	and,PKCζ
R2232	T2551	T2546	conj	Ser536,PKCζ
R2233	T2552	T2529	agent	by,enhanced
R2234	T2553	T2552	pobj	IKKα,by
R2236	T2554	T2555	punct	(,"10,11"
R2237	T2555	T2553	parataxis	"10,11",IKKα
R2238	T2556	T2529	punct	),enhanced
R2240	T2557	T2529	punct	.,enhanced
R2241	T2558	T2565	nsubj	Acetylation,increases
R2242	T2559	T2558	prep	of,Acetylation
R2243	T2560	T2559	pobj	p65,of
R2245	T2561	T2558	prep	at,Acetylation
R2246	T2562	T2561	pobj	Lys218,at
R2248	T2563	T2562	cc	and,Lys218
R2249	T2564	T2562	conj	Lys221,Lys218
R2250	T2565	T2565	ROOT	increases,increases
R2251	T2566	T2567	det	the,DNA
R2252	T2567	T2565	dobj	DNA,increases
R2253	T2568	T2565	advcl	binding,increases
R2255	T2569	T2565	cc	and,increases
R2256	T2570	T2565	conj	impairs,increases
R2260	T2427	T2426	prep	with,associate
R2261	T2571	T2572	det	the,association
R2262	T2572	T2570	dobj	association,impairs
R2263	T2573	T2572	prep	with,association
R2264	T2574	T2573	pobj	IκB-α,with
R2265	T2428	T2430	det	the,complex
R2266	T2575	T2574	punct	",",IκB-α
R2267	T2576	T2572	cc	and,association
R2268	T2577	T2572	conj	acetylation,association
R2269	T2429	T2430	compound	NF-κB,complex
R2270	T2578	T2570	prep	at,impairs
R2271	T2579	T2578	pobj	Lys310,at
R2272	T2430	T2427	pobj	complex,with
R2273	T2580	T2565	conj	enhances,increases
R2274	T2581	T2584	det	the,activity
R2275	T2582	T2584	nummod	p65,activity
R2276	T2431	T2420	cc	and,Inhibitors
R2277	T2583	T2584	amod	transcriptional,activity
R2278	T2584	T2580	dobj	activity,enhances
R2279	T2585	T2584	punct	(,activity
R2280	T2432	T2432	ROOT	interfere,interfere
R2281	T2586	T2584	appos	"12,13",activity
R2282	T2587	T2584	punct	),activity
R2283	T2588	T2565	punct	.,increases
R2284	T2433	T2432	prep	with,interfere
R2285	T2589	T2590	nsubj	Post-activation,turn
R2286	T2590	T2595	nsubjpass	turn,regulated
R2287	T2591	T2590	prt	off,turn
R2288	T2434	T2435	poss	its,binding
R2289	T2592	T2591	prep	of,off
R2290	T2593	T2592	pobj	NF-κB,of
R2291	T2594	T2595	auxpass	is,regulated
R2292	T2435	T2433	pobj	binding,with
R2293	T2595	T2595	ROOT	regulated,regulated
R2294	T2596	T2595	agent	by,regulated
R2295	T2597	T2599	amod	negative,loop
R2296	T2436	T2435	prep	to,binding
R2297	T2598	T2599	compound	feedback,loop
R2298	T2599	T2596	pobj	loop,by
R2299	T2600	T2595	prep	through,regulated
R2300	T2601	T2600	pobj	inhibitors,through
R2301	T2602	T2601	prep	under,inhibitors
R2302	T2603	T2605	det	the,control
R2303	T2437	T2436	pobj	DNA,to
R2304	T2604	T2605	amod	transcriptional,control
R2305	T2605	T2602	pobj	control,under
R2306	T2606	T2605	prep	of,control
R2307	T2607	T2606	pobj	NF-κB,of
R2308	T2438	T2439	punct	(,3
R2309	T2608	T2601	punct	",",inhibitors
R2310	T2609	T2610	amod	such,as
R2311	T2610	T2601	prep	as,inhibitors
R2312	T2439	T2437	appos	3,DNA
R2313	T2440	T2439	punct	),3
R2314	T2611	T2615	amod	IκB-α,A20
R2315	T2441	T2432	punct	.,interfere
R2316	T2612	T2611	cc	and,IκB-α
R2317	T2613	T2611	conj	ubiquitin-editing,IκB-α
R2318	T2614	T2615	compound	protein,A20
R2319	T2442	T2457	prep	In,phosphorylates
R2320	T2615	T2610	pobj	A20,as
R2321	T2616	T2615	punct	(,A20
R2322	T2617	T2615	appos	14,A20
R2323	T2443	T2445	det	the,pathway
R2324	T2618	T2617	prep	20,14
R2325	T2619	T2617	punct	),14
R2326	T2620	T2595	punct	.,regulated
R2327	T2444	T2445	amod	canonical,pathway
R2328	T2621	T2638	nsubj	Deacetylation,down-regulate
R2329	T2622	T2621	prep	of,Deacetylation
R2330	T2623	T2622	pobj	p65,of
R2331	T2445	T2442	pobj	pathway,In
R2332	T2624	T2621	prep	by,Deacetylation
R2333	T2625	T2624	pobj	histone,by
R2334	T2626	T2621	conj	deacetylase-3,Deacetylation
R2335	T2446	T2445	prep	of,pathway
R2336	T2627	T2626	cc	or,deacetylase-3
R2337	T2628	T2626	conj	SIRT1,deacetylase-3
R2338	T2629	T2628	punct	",",SIRT1
R2339	T2447	T2448	amod	NF-κB,activation
R2340	T2630	T2628	cc	or,SIRT1
R2341	T2631	T2628	conj	acetylation,SIRT1
R2342	T2632	T2631	prep	of,acetylation
R2343	T2633	T2632	pobj	p65,of
R2344	T2448	T2446	pobj	activation,of
R2345	T2634	T2631	prep	at,acetylation
R2346	T2635	T2634	pobj	Lys122,at
R2347	T2636	T2635	cc	and,Lys122
R2348	T2449	T2457	punct	",",phosphorylates
R2349	T2637	T2635	conj	Lys123,Lys122
R2350	T2638	T2638	ROOT	down-regulate,down-regulate
R2351	T2639	T2641	det	the,activity
R2352	T2640	T2641	compound	NF-κB,activity
R2353	T2641	T2638	dobj	activity,down-regulate
R2354	T2450	T2453	det	the,kinase
R2355	T2642	T2641	punct	(,activity
R2356	T2643	T2641	appos	"12,21,22",activity
R2357	T2644	T2641	punct	),activity
R2358	T2451	T2453	amod	activated,kinase
R2359	T2645	T2638	punct	.,down-regulate
R2360	T2646	T2647	amod	Persistent,activation
R2361	T2647	T2650	nsubj	activation,occurs
R2362	T2452	T2453	compound	IκB,kinase
R2363	T2648	T2647	prep	of,activation
R2364	T2649	T2648	pobj	NF-κB,of
R2365	T2453	T2457	nsubj	kinase,phosphorylates
R2366	T2650	T2650	ROOT	occurs,occurs
R2367	T2454	T2455	punct	(,IKK
R2368	T2651	T2650	prep	in,occurs
R2369	T2652	T2653	amod	human,immunodeficiency
R2370	T2653	T2651	pobj	immunodeficiency,in
R2371	T2455	T2453	appos	IKK,kinase
R2372	T2654	T2656	amod	virus-1,HIV-1
R2373	T2655	T2656	punct	(,HIV-1
R2374	T2656	T2650	npadvmod	HIV-1,occurs
R2375	T2456	T2453	punct	),kinase
R2376	T2657	T2656	punct	),HIV-1
R2377	T2658	T2659	punct	-,infected
R2378	T2659	T2660	amod	infected,monocytes
R2379	T2457	T2457	ROOT	phosphorylates,phosphorylates
R2380	T2660	T2650	conj	monocytes,occurs
R2381	T2661	T2660	punct	",",monocytes
R2382	T2662	T2660	conj	macrophages,monocytes
R2383	T2458	T2457	dobj	IκB,phosphorylates
R2384	T2663	T2662	cc	and,macrophages
R2385	T2664	T2662	conj	microglia,macrophages
R2386	T2665	T2650	punct	",",occurs
R2387	T2459	T2457	prep	at,phosphorylates
R2388	T2666	T2650	cc	and,occurs
R2389	T2667	T2650	conj	enhances,occurs
R2390	T2460	T2462	amod	specific,residues
R2391	T2461	T2462	compound	serine,residues
R2392	T2462	T2459	pobj	residues,at
R2393	T2668	T2669	det	the,expression
R2394	T2463	T2464	nsubj	that,target
R2395	T2669	T2667	dobj	expression,enhances
R2396	T2670	T2669	prep	of,expression
R2397	T2671	T2672	amod	NF-κB-responsive,genes
R2398	T2464	T2462	relcl	target,residues
R2399	T2672	T2670	pobj	genes,of
R2400	T2673	T2672	punct	",",genes
R2401	T2674	T2672	prep	including,genes
R2402	T2675	T2676	amod	pro-inflammatory,cytokines
R2403	T2676	T2674	pobj	cytokines,including
R2404	T2677	T2676	punct	",",cytokines
R2405	T2465	T2466	det	the,protein
R2406	T2678	T2679	compound	cell,adhesion
R2407	T2679	T2680	compound	adhesion,molecules
R2408	T2680	T2676	conj	molecules,cytokines
R2409	T2681	T2680	cc	and,molecules
R2410	T2466	T2464	dobj	protein,target
R2411	T2682	T2680	conj	chemokines,molecules
R2412	T2683	T2682	punct	(,chemokines
R2413	T2467	T2468	aux	to,ubiquitination
R2414	T2684	T2685	nummod	23,25
R2415	T2685	T2682	appos	25,chemokines
R2416	T2686	T2682	punct	),chemokines
R2417	T2468	T2464	advcl	ubiquitination,target
R2418	T2687	T2650	punct	.,occurs
R2419	T2688	T2689	amod	Chronic,inflammation
R2420	T2689	T2690	nsubj	inflammation,is
R2421	T2469	T2468	cc	and,ubiquitination
R2422	T2690	T2690	ROOT	is,is
R2423	T2691	T2693	det	a,cause
R2424	T2692	T2693	amod	major,cause
R2425	T2470	T2471	amod	proteasomal,degradation
R2426	T2693	T2690	attr	cause,is
R2427	T2694	T2693	prep	of,cause
R2428	T2695	T2698	amod	immune,dysfunction
R2429	T2471	T2468	conj	degradation,ubiquitination
R2430	T2696	T2695	cc	and,immune
R2431	T2697	T2695	conj	neuron,immune
R2432	T2698	T2694	pobj	dysfunction,of
R2433	T2472	T2471	punct	",",degradation
R2434	T2699	T2698	prep	in,dysfunction
R2435	T2700	T2699	pobj	AIDS,in
R2436	T2701	T2702	punct	(,"26,27"
R2437	T2473	T2474	nsubj	which,releases
R2438	T2702	T2698	appos	"26,27",dysfunction
R2439	T2703	T2690	punct	),is
R2440	T2765	T2764	prep	of,binding
R2441	T2704	T2690	punct	.,is
R2442	T2705	T2709	advmod	Consistently,hosts
R2443	T2706	T2709	punct	",",hosts
R2444	T2766	T2769	det	the,envelope
R2445	T2707	T2709	amod	non-human,hosts
R2446	T2708	T2709	compound	primate,hosts
R2447	T2709	T2709	ROOT	hosts,hosts
R2448	T2767	T2769	nmod	gp120,envelope
R2449	T2710	T2709	prep	for,hosts
R2450	T2711	T2713	amod	simian,virus
R2451	T2712	T2713	compound	immunodeficiency,virus
R2452	T2713	T2710	pobj	virus,for
R2453	T2768	T2769	amod	viral,envelope
R2454	T2714	T2709	punct	",",hosts
R2455	T2715	T2716	amod	such,as
R2456	T2716	T2709	prep	as,hosts
R2457	T2717	T2719	amod	African,monkeys
R2458	T2769	T2765	pobj	envelope,of
R2459	T2718	T2719	amod	green,monkeys
R2460	T2719	T2716	pobj	monkeys,as
R2461	T2720	T2719	cc	and,monkeys
R2462	T2721	T2722	amod	sooty,mangabey
R2463	T2770	T2772	advmod	to,induces
R2464	T2722	T2719	conj	mangabey,monkeys
R2465	T2723	T2709	punct	",",hosts
R2466	T2724	T2709	conj	lack,hosts
R2467	T2771	T2772	nsubj	CD4,induces
R2468	T2725	T2727	amod	aberrant,activation
R2469	T2726	T2727	amod	immune,activation
R2470	T2727	T2724	dobj	activation,lack
R2471	T2728	T2724	cc	and,lack
R2472	T2772	T2772	ROOT	induces,induces
R2473	T2773	T2775	det	the,activity
R2475	T2774	T2775	amod	NF-κB,activity
R2479	T2775	T2772	dobj	activity,induces
R2483	T2776	T2775	prep	by,activity
R2486	T2777	T2776	pobj	activation,by
R2489	T2778	T2777	prep	of,activation
R2490	T2779	T2778	pobj	IKK,of
R2492	T2741	T2752	advmod	Thus,provide
R2493	T2780	T2779	punct	(,IKK
R2494	T2742	T2752	punct	",",provide
R2495	T2743	T2752	csubj	understanding,provide
R2496	T2781	T2779	appos	30,IKK
R2497	T2744	T2745	det	the,mechanisms
R2498	T2745	T2743	dobj	mechanisms,understanding
R2499	T2746	T2745	prep	of,mechanisms
R2500	T2782	T2779	punct	),IKK
R2501	T2747	T2748	amod	NF-κB,deregulation
R2502	T2748	T2746	pobj	deregulation,of
R2503	T2749	T2745	prep	by,mechanisms
R2504	T2750	T2749	pobj	HIV-1,by
R2505	T2751	T2752	aux	may,provide
R2506	T2752	T2752	ROOT	provide,provide
R2507	T2783	T2777	cc	and,activation
R2508	T2753	T2754	amod	further,insights
R2509	T2754	T2752	dobj	insights,provide
R2510	T2755	T2752	prep	into,provide
R2511	T2784	T2777	conj	procaspase,activation
R2512	T2756	T2757	compound	AIDS,pathogenesis
R2513	T2757	T2755	pobj	pathogenesis,into
R2514	T2758	T2752	punct	.,provide
R2515	T2785	T2784	nummod	8,procaspase
R2516	T2759	T2772	prep	In,induces
R2517	T2760	T2761	compound	HIV-1,entry
R2518	T2761	T2759	pobj	entry,In
R2519	T2762	T2772	punct	",",induces
R2520	T2786	T2787	punct	(,31
R2521	T2763	T2764	det	the,binding
R2522	T2764	T2772	nsubj	binding,induces
R2523	T2787	T2784	npadvmod	31,procaspase
R2524	T2788	T2772	punct	),induces
R2525	T2789	T2772	punct	.,induces
R2526	T2790	T2800	prep	Following,interacts
R2527	T2830	T2829	punct	",",transcripts
R2528	T2831	T2829	prep	including,transcripts
R2529	T2791	T2792	amod	viral,integration
R2530	T2832	T2835	det	the,element
R2531	T2833	T2835	nmod	HIV-1,element
R2532	T2792	T2790	pobj	integration,Following
R2533	T2834	T2835	amod	transactivation-responsive,element
R2534	T2835	T2831	pobj	element,including
R2535	T2836	T2835	punct	(,element
R2536	T2837	T2835	appos	TAR,element
R2537	T2793	T2800	punct	",",interacts
R2538	T2838	T2835	punct	),element
R2539	T2839	T2835	punct	(,element
R2540	T2794	T2799	det	the,protein
R2541	T2840	T2835	appos	32,element
R2542	T2841	T2835	punct	),element
R2543	T2842	T2835	punct	",",element
R2544	T2795	T2799	amod	early,protein
R2545	T2843	T2844	compound	tumor,necrosis
R2546	T2844	T2845	compound	necrosis,factor
R2547	T2796	T2799	amod	encoded,protein
R2548	T2845	T2846	compound	factor,β
R2549	T2846	T2835	appos	β,element
R2550	T2847	T2846	punct	(,β
R2551	T2797	T2798	compound	HIV-1,Tat
R2552	T2848	T2846	appos	TNFβ,β
R2553	T2849	T2846	punct	),β
R2554	T2850	T2846	punct	(,β
R2555	T2851	T2846	appos	33,β
R2556	T2852	T2846	punct	),β
R2557	T2798	T2799	compound	Tat,protein
R2558	T2853	T2846	cc	and,β
R2559	T2854	T2846	conj	interleukin-6,β
R2560	T2799	T2800	nsubj	protein,interacts
R2561	T2855	T2856	punct	(,IL-6
R2562	T2856	T2854	appos	IL-6,interleukin-6
R2563	T2857	T2854	punct	),interleukin-6
R2564	T2800	T2800	ROOT	interacts,interacts
R2565	T2858	T2854	punct	(,interleukin-6
R2566	T2859	T2854	appos	34,interleukin-6
R2567	T2860	T2854	punct	),interleukin-6
R2568	T2801	T2800	prep	with,interacts
R2569	T2861	T2862	aux	to,activate
R2570	T2802	T2804	det	the,RNA
R2571	T2803	T2804	compound	HIV-1,RNA
R2572	T2862	T2835	relcl	activate,element
R2573	T2804	T2801	pobj	RNA,with
R2574	T2863	T2864	compound	gene,transcription
R2575	T2864	T2862	dobj	transcription,activate
R2576	T2865	T2816	punct	.,binds
R2577	T2805	T2804	cc	and,RNA
R2578	T2866	T2869	advmod	Indeed,promotes
R2579	T2867	T2869	punct	",",promotes
R2580	T2868	T2869	nsubj	Tat,promotes
R2581	T2806	T2807	compound	host,cell
R2582	T2869	T2869	ROOT	promotes,promotes
R2583	T2870	T2872	det	the,initiation
R2584	T2871	T2872	amod	transcriptional,initiation
R2585	T2807	T2808	compound	cell,factors
R2586	T2872	T2869	dobj	initiation,promotes
R2587	T2873	T2872	cc	and,initiation
R2588	T2874	T2872	conj	elongation,initiation
R2589	T2808	T2804	conj	factors,RNA
R2590	T2875	T2869	prep	by,promotes
R2591	T2876	T2875	pcomp	interacting,by
R2592	T2877	T2876	prep	with,interacting
R2593	T2878	T2879	amod	transacting,factors
R2594	T2809	T2810	aux	to,sustain
R2595	T2879	T2877	pobj	factors,with
R2596	T2880	T2879	cc	and,factors
R2597	T2881	T2879	conj	cofactors,factors
R2598	T2810	T2800	xcomp	sustain,interacts
R2599	T2882	T2881	punct	",",cofactors
R2600	T2883	T2884	amod	such,as
R2601	T2884	T2879	prep	as,factors
R2602	T2885	T2884	pobj	Sp1,as
R2603	T2886	T2885	punct	(,Sp1
R2604	T2811	T2813	det	the,replication
R2605	T2812	T2813	amod	viral,replication
R2609	T2813	T2810	dobj	replication,sustain
R2613	T2814	T2800	punct	.,interacts
R2616	T2815	T2816	nsubj	Tat,binds
R2619	T2816	T2816	ROOT	binds,binds
R2621	T2817	T2816	prep	to,binds
R2625	T2818	T2817	pobj	RNA,to
R2629	T2819	T2820	amod	stem-loop,structures
R2633	T2820	T2818	dobj	structures,RNA
R2634	T2907	T2906	nummod	T1/CDK9,cyclin
R2635	T2908	T2909	punct	(,"39,40"
R2636	T2909	T2906	appos	"39,40",cyclin
R2637	T2821	T2820	acl	generated,structures
R2638	T2910	T2906	punct	),cyclin
R2639	T2911	T2906	cc	and,cyclin
R2640	T2912	T2913	det	the,histone
R2641	T2822	T2821	agent	by,generated
R2642	T2913	T2906	conj	histone,cyclin
R2643	T2914	T2869	conj	acetyltransferases,promotes
R2644	T2915	T2914	appos	p300/CBP,acetyltransferases
R2645	T2916	T2915	cc	and,p300/CBP
R2646	T2823	T2826	det	the,end
R2647	T2917	T2915	conj	P/CAF,p300/CBP
R2648	T2918	T2917	punct	(,P/CAF
R2649	T2919	T2917	appos	41,P/CAF
R2650	T2920	T2917	appos	43,P/CAF
R2651	T2824	T2825	nummod	5,′
R2652	T2921	T2917	punct	),P/CAF
R2653	T2922	T2869	punct	.,promotes
R2654	T2923	T2924	advmod	When,released
R2655	T2924	T2930	advcl	released,deregulates
R2656	T2925	T2924	prep	from,released
R2657	T2926	T2927	amod	HIV-1-infected,cells
R2658	T2825	T2826	compound	′,end
R2659	T2927	T2925	pobj	cells,from
R2660	T2928	T2930	punct	",",deregulates
R2661	T2929	T2930	nsubj	Tat,deregulates
R2662	T2826	T2822	pobj	end,by
R2663	T2930	T2930	ROOT	deregulates,deregulates
R2664	T2931	T2932	det	the,cell
R2665	T2932	T2930	dobj	cell,deregulates
R2666	T2827	T2826	prep	of,end
R2667	T2933	T2932	acl	signaling,cell
R2668	T2934	T2933	prep	by,signaling
R2669	T2935	T2934	pcomp	binding,by
R2670	T2936	T2935	prep	to,binding
R2671	T2828	T2829	compound	target,transcripts
R2672	T2937	T2938	compound	cell,receptors
R2673	T2938	T2936	pobj	receptors,to
R2674	T2939	T2938	punct	",",receptors
R2675	T2829	T2827	pobj	transcripts,of
R2676	T2940	T2941	amod	such,as
R2677	T2941	T2938	prep	as,receptors
R2678	T2942	T2941	pobj	integrins,as
R2679	T2943	T2942	punct	(,integrins
R2680	T2959	T2961	nsubj	We,reported
R2681	T2944	T2942	appos	44,integrins
R2682	T2945	T2942	punct	),integrins
R2683	T2946	T2938	punct	",",receptors
R2684	T2947	T2948	compound	Flk1/KDR,receptor
R2685	T2960	T2961	advmod	first,reported
R2686	T2948	T2938	appos	receptor,receptors
R2687	T2949	T2948	punct	(,receptor
R2688	T2950	T2948	appos	45,receptor
R2689	T2951	T2948	punct	),receptor
R2690	T2961	T2961	ROOT	reported,reported
R2691	T2952	T2948	cc	and,receptor
R2692	T2953	T2954	amod	chemokine,receptors
R2693	T2954	T2948	conj	receptors,receptor
R2694	T2962	T2964	mark	that,was
R2695	T2955	T2954	punct	(,receptors
R2696	T2956	T2954	appos	46,receptors
R2697	T2957	T2954	punct	),receptors
R2698	T2958	T2930	punct	.,deregulates
R2699	T2963	T2964	nsubj	NF-κB,was
R2700	T2964	T2961	ccomp	was,reported
R2701	T2965	T2966	advmod	constitutively,active
R2702	T2966	T2964	acomp	active,was
R2703	T3056	T3055	pobj	IκB-α,of
R2704	T3057	T3058	punct	(,"15,17"
R2705	T3058	T3056	parataxis	"15,17",IκB-α
R2706	T2967	T2966	prep	in,active
R2707	T3059	T3040	punct	),subvert
R2708	T3060	T3035	punct	.,was
R2709	T3061	T3063	nsubj	We,found
R2710	T2968	T2969	compound	Jurkat,cells
R2711	T3062	T3063	advmod	previously,found
R2712	T3063	T3063	ROOT	found,found
R2713	T3064	T3070	mark	that,promotes
R2714	T2969	T2967	pobj	cells,in
R2715	T3065	T3066	amod	IκB-α,binds
R2716	T3066	T3070	nsubj	binds,promotes
R2717	T3067	T3066	prep	to,binds
R2718	T2970	T2972	nsubj	that,expressed
R2719	T3068	T3067	pobj	Tat,to
R2720	T3069	T3066	cc	and,binds
R2721	T3070	T3063	ccomp	promotes,found
R2722	T2971	T2972	advmod	stably,expressed
R2723	T3071	T3073	det	the,export
R2724	T3072	T3073	amod	nuclear,export
R2725	T2972	T2961	ccomp	expressed,reported
R2726	T3073	T3070	dobj	export,promotes
R2727	T3074	T3073	prep	of,export
R2728	T3075	T3077	det	the,transactivator
R2729	T3076	T3077	amod	viral,transactivator
R2730	T2973	T2975	det	the,gene
R2731	T3077	T3074	pobj	transactivator,of
R2732	T3078	T3077	punct	(,transactivator
R2733	T3079	T3077	appos	"50,51",transactivator
R2734	T2974	T2975	compound	Tat,gene
R2735	T3080	T3077	punct	),transactivator
R2736	T3081	T3063	punct	.,found
R2737	T3082	T3087	prep	In,report
R2738	T3083	T3084	det	this,study
R2739	T3084	T3082	pobj	study,In
R2740	T3085	T3087	punct	",",report
R2741	T3086	T3087	nsubj	we,report
R2742	T3087	T3087	ROOT	report,report
R2743	T2975	T2972	dobj	gene,expressed
R2744	T3088	T3090	mark	that,counteracts
R2745	T3089	T3090	nsubj	Tat,counteracts
R2746	T3090	T3087	ccomp	counteracts,report
R2747	T2976	T2975	punct	(,gene
R2748	T3091	T3093	det	the,turn
R2749	T3092	T3093	amod	post-activation,turn
R2750	T3093	T3090	dobj	turn,counteracts
R2751	T2977	T2975	appos	47,gene
R2752	T3094	T3093	prt	off,turn
R2753	T3095	T3093	prep	of,turn
R2754	T3096	T3095	pobj	NF-κB,of
R2755	T3097	T3090	prep	through,counteracts
R2756	T3098	T3099	amod	direct,interaction
R2757	T2978	T2975	punct	),gene
R2758	T3099	T3097	pobj	interaction,through
R2759	T3100	T3099	prep	with,interaction
R2760	T3101	T3100	pobj	IκB-α,with
R2761	T3102	T3101	cc	and,IκB-α
R2762	T2979	T2961	punct	.,reported
R2763	T3103	T3101	conj	p65,IκB-α
R2764	T3104	T3101	punct	",",IκB-α
R2765	T3105	T3106	nsubj	which,enhances
R2766	T2980	T2988	prep	Following,induced
R2767	T3106	T3101	relcl	enhances,IκB-α
R2768	T3107	T3108	det	the,DNA
R2769	T3108	T3106	dobj	DNA,enhances
R2770	T2981	T2982	compound	gene,transfection
R2771	T2982	T2980	pobj	transfection,Following
R2772	T3109	T3112	amod	binding,activity
R2773	T2983	T2982	cc	or,transfection
R2774	T3110	T3109	cc	and,binding
R2775	T3111	T3109	conj	transcriptional,binding
R2776	T3112	T3106	dobj	activity,enhances
R2777	T2984	T2985	compound	protein,transduction
R2778	T3113	T3112	prep	of,activity
R2779	T3114	T3116	det	the,complex
R2780	T3115	T3116	compound	NF-κB,complex
R2781	T3116	T3113	pobj	complex,of
R2782	T2985	T2982	conj	transduction,transfection
R2783	T3117	T3087	punct	.,report
R2784	T3118	T3120	det	The,mechanism
R2785	T3119	T3120	amod	new,mechanism
R2786	T2986	T2988	punct	",",induced
R2787	T3120	T3125	nsubj	mechanism,described
R2788	T3121	T3120	prep	of,mechanism
R2789	T2987	T2988	nsubj	Tat,induced
R2790	T3122	T3123	amod	NF-κB,deregulation
R2791	T2988	T2988	ROOT	induced,induced
R2792	T3123	T3121	pobj	deregulation,of
R2793	T3124	T3120	advmod	here,mechanism
R2794	T3125	T3125	ROOT	described,described
R2795	T2989	T2991	det	the,activity
R2796	T3126	T3127	aux	may,provide
R2797	T3127	T3125	ccomp	provide,described
R2798	T2990	T2991	compound	IKK,activity
R2799	T3128	T3129	amod	further,insights
R2800	T3129	T3127	dobj	insights,provide
R2801	T3130	T3129	prep	into,insights
R2802	T2991	T2988	dobj	activity,induced
R2803	T3131	T3134	det	the,activation
R2804	T3132	T3134	amod	chronic,activation
R2805	T3133	T3134	amod	immune,activation
R2806	T3134	T3130	pobj	activation,into
R2807	T3135	T3134	prep	of,activation
R2808	T3136	T3137	amod	HIV-1,infection
R2809	T2992	T2991	cc	and,activity
R2810	T3137	T3135	pobj	infection,of
R2811	T3138	T3125	punct	.,described
R2812	T2993	T2994	amod	proteasomal,degradation
R2813	T2994	T2991	conj	degradation,activity
R2814	T2995	T2994	prep	of,degradation
R2815	T2996	T2995	pobj	IκB-α,of
R2816	T2997	T2996	punct	(,IκB-α
R2817	T2998	T2996	appos	48,IκB-α
R2818	T2999	T2996	punct	),IκB-α
R2819	T3000	T2988	punct	",",induced
R2820	T3001	T2988	cc	and,induced
R2821	T3002	T2988	conj	increased,induced
R2822	T3003	T3006	det	the,activity
R2823	T3004	T3006	nmod	p65,activity
R2824	T3005	T3006	compound	transcriptional,activity
R2825	T3006	T3002	dobj	activity,increased
R2826	T3007	T3002	prep	by,increased
R2827	T3008	T3007	pcomp	inhibiting,by
R2828	T3009	T3011	det	the,deacetylation
R2829	T3010	T3011	amod	SIRT-1-mediated,deacetylation
R2830	T3011	T3008	dobj	deacetylation,inhibiting
R2831	T3012	T3011	prep	of,deacetylation
R2832	T3013	T3014	compound	p65,Lys310
R2833	T3014	T3012	pobj	Lys310,of
R2834	T3015	T3014	punct	(,Lys310
R2835	T3016	T3014	appos	49,Lys310
R2836	T3017	T3014	punct	),Lys310
R2837	T3018	T2988	punct	.,induced
R2838	T3019	T3020	det	These,findings
R2839	T3020	T3021	nsubj	findings,suggested
R2840	T3021	T3035	ccomp	suggested,was
R2841	T3022	T3024	mark	that,modulates
R2842	T3023	T3024	nsubj	Tat,modulates
R2843	T3024	T3021	ccomp	modulates,suggested
R2844	T3025	T3026	amod	crucial,enzymes
R2845	T3026	T3024	dobj	enzymes,modulates
R2846	T3027	T3026	acl	involved,enzymes
R2847	T3028	T3027	prep	in,involved
R2848	T3029	T3030	amod	NF-κB,signaling
R2849	T3030	T3024	prep	signaling,modulates
R2850	T3031	T3035	punct	;,was
R2851	T3032	T3035	advmod	however,was
R2852	T3033	T3035	punct	",",was
R2853	T3034	T3035	nsubj	it,was
R2854	T3035	T3035	ROOT	was,was
R2855	T3036	T3035	acomp	unclear,was
R2856	T3037	T3040	advmod	how,subvert
R2857	T3038	T3040	nsubj	Tat,subvert
R2858	T3039	T3040	aux	could,subvert
R2859	T3040	T3035	ccomp	subvert,was
R2860	T3041	T3043	det	the,feedback
R2861	T3042	T3043	amod	negative,feedback
R2871	T3052	T3054	nmod	de,synthesis
R2872	T3053	T3054	amod	novo,synthesis
R2873	T3054	T3051	pobj	synthesis,on
R2874	T3055	T3054	prep	of,synthesis
R2197	T2412	T2411	punct	",",p65
R2209	T2413	T2407	npadvmod	RelB,are
R2214	T2414	T2413	cc	and,RelB
R2218	T2415	T2413	conj	c-Rel,RelB
R2222	T2416	T2417	punct	(,2
R2226	T2417	T2413	appos	2,RelB
R2230	T2418	T2417	punct	),2
R2235	T2419	T2397	punct	.,depends
R2239	T2420	T2432	nsubj	Inhibitors,interfere
R2244	T2421	T2420	prep	of,Inhibitors
R2247	T2422	T2421	pobj	NF-κB,of
R2254	T2423	T2422	punct	(,NF-κB
R2257	T2424	T2422	appos	IκB,NF-κB
R2258	T2425	T2422	punct	),NF-κB
R2259	T2426	T2420	appos	associate,Inhibitors
R2474	T2729	T2731	aux	do,develop
R2476	T2730	T2731	neg	not,develop
R2477	T2731	T2724	conj	develop,lack
R2478	T2732	T2731	dobj	AIDS,develop
R2480	T2733	T2731	prep	despite,develop
R2481	T2734	T2736	amod	high,replication
R2482	T2735	T2736	compound	virus,replication
R2484	T2736	T2733	pobj	replication,despite
R2485	T2737	T2736	punct	(,replication
R2487	T2738	T2736	appos	"28,29",replication
R2488	T2739	T2736	punct	),replication
R2491	T2740	T2709	punct	.,hosts
R2606	T2887	T2885	appos	35,Sp1
R2607	T2888	T2885	punct	),Sp1
R2608	T2889	T2885	punct	",",Sp1
R2610	T2890	T2885	conj	TFIID,Sp1
R2611	T2891	T2890	punct	(,TFIID
R2612	T2892	T2890	appos	36,TFIID
R2614	T2893	T2890	punct	),TFIID
R2615	T2894	T2890	punct	",",TFIID
R2617	T2895	T2890	conj	E2F-4,TFIID
R2618	T2896	T2895	punct	(,E2F-4
R2620	T2897	T2895	appos	37,E2F-4
R2622	T2898	T2895	punct	),E2F-4
R2623	T2899	T2895	punct	",",E2F-4
R2624	T2900	T2901	compound	C/EBP,β
R2626	T2901	T2895	conj	β,E2F-4
R2627	T2902	T2901	punct	(,β
R2628	T2903	T2901	appos	38,β
R2630	T2904	T2901	punct	),β
R2631	T2905	T2901	punct	",",β
R2632	T2906	T2914	nmod	cyclin,acetyltransferases
R2862	T3043	T3040	dobj	feedback,subvert
R2863	T3044	T3043	prep	of,feedback
R2864	T3045	T3044	pobj	NF-κB,of
R2865	T3046	T3045	punct	",",NF-κB
R2866	T3047	T3048	nsubj	which,is
R2867	T3048	T3045	relcl	is,NF-κB
R2868	T3049	T3050	advmod	mainly,dependent
R2869	T3050	T3048	acomp	dependent,is
R2870	T3051	T3050	prep	on,dependent

GO-BP

Id	Subject	Object	Predicate	Lexical cue
T3164	36-49	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T3165	71-84	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T3166	2954-2967	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcription
T3167	2994-3009	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T3168	3674-3689	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T3169	4278-4293	http://purl.obolibrary.org/obo/GO_0006351	denotes	transcriptional
T3170	130-151	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammatory response
T3171	2012-2024	http://purl.obolibrary.org/obo/GO_0006954	denotes	inflammation
T3172	662-678	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activation
T3173	1747-1766	http://purl.obolibrary.org/obo/GO_0051092	denotes	activation of NF-κB
T3174	2505-2533	http://purl.obolibrary.org/obo/GO_0051092	denotes	NF-κB activity by activation
T3175	706-709	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T3176	959-962	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T3177	2537-2540	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T3178	3596-3599	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T3179	774-799	http://purl.obolibrary.org/obo/GO_0016567	denotes	protein to ubiquitination
T3180	816-827	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T3181	3625-3636	http://purl.obolibrary.org/obo/GO_0009056	denotes	degradation
T3182	914-932	http://purl.obolibrary.org/obo/GO_0032088	denotes	inhibitor of NF-κB
T3183	914-932	http://purl.obolibrary.org/obo/GO_0007252	denotes	inhibitor of NF-κB
T3184	1113-1128	http://purl.obolibrary.org/obo/GO_0016310	denotes	phosphorylation
T3185	1149-1152	http://purl.obolibrary.org/obo/GO_0004691	denotes	PKA
T3186	1179-1183	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKCζ
T3187	1501-1524	http://purl.obolibrary.org/obo/GO_0006355	denotes	transcriptional control
T3188	1956-1969	http://purl.obolibrary.org/obo/GO_0007155	denotes	cell adhesion
T3189	1956-1979	http://purl.obolibrary.org/obo/GO_0060352	denotes	cell adhesion molecules
T3190	2416-2428	http://purl.obolibrary.org/obo/GO_0009405	denotes	pathogenesis
T3191	2700-2717	http://purl.obolibrary.org/obo/GO_0019058	denotes	viral replication
T3192	2700-2717	http://purl.obolibrary.org/obo/GO_0019079	denotes	viral replication
T3193	2824-2839	http://purl.obolibrary.org/obo/GO_2000144	denotes	transactivation
T3194	2877-2885	http://purl.obolibrary.org/obo/GO_0001906	denotes	necrosis
T3195	2877-2885	http://purl.obolibrary.org/obo/GO_0008219	denotes	necrosis
T3196	2877-2885	http://purl.obolibrary.org/obo/GO_0019835	denotes	necrosis
T3197	2877-2885	http://purl.obolibrary.org/obo/GO_0070265	denotes	necrosis
T3198	3146-3152	http://purl.obolibrary.org/obo/GO_0016538	denotes	cyclin
T3199	3298-3307	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T3200	3845-3854	http://purl.obolibrary.org/obo/GO_0023052	denotes	signaling
T3201	3566-3578	http://purl.obolibrary.org/obo/GO_0009293	denotes	transduction
T3202	3839-3854	http://purl.obolibrary.org/obo/GO_0038061	denotes	NF-κB signaling
T3203	3971-3980	http://purl.obolibrary.org/obo/GO_0009058	denotes	synthesis
T3204	4060-4074	http://purl.obolibrary.org/obo/GO_0051168	denotes	nuclear export

GO-MF

Id	Subject	Object	Predicate	Lexical cue
T3224	326-337	http://purl.obolibrary.org/obo/GO_0003677	denotes	DNA-binding
T3225	614-628	http://purl.obolibrary.org/obo/GO_0003677	denotes	binding to DNA
T3226	1270-1281	http://purl.obolibrary.org/obo/GO_0003677	denotes	DNA binding
T3227	4262-4273	http://purl.obolibrary.org/obo/GO_0003677	denotes	DNA binding
T3228	330-337	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T3229	614-621	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T3230	1274-1281	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T3231	2450-2457	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T3232	3311-3318	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T3233	4266-4273	http://purl.obolibrary.org/obo/GO_0005488	denotes	binding
T3234	706-709	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T3235	959-962	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T3236	2537-2540	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T3237	3596-3599	http://purl.obolibrary.org/obo/GO_0008384	denotes	IKK
T3238	1149-1152	http://purl.obolibrary.org/obo/GO_0004691	denotes	PKA
T3239	1179-1183	http://purl.obolibrary.org/obo/GO_0004697	denotes	PKCζ
T3240	1553-1562	http://purl.obolibrary.org/obo/GO_0031386	denotes	ubiquitin
T3241	2923-2928	http://purl.obolibrary.org/obo/GO_0005138	denotes	6 (IL
T3242	3146-3152	http://purl.obolibrary.org/obo/GO_0016538	denotes	cyclin
T3243	3209-3212	http://purl.obolibrary.org/obo/GO_0008140	denotes	CBP

GO-CC

Id	Subject	Object	Predicate	Lexical cue
T3205	375-388	http://purl.obolibrary.org/obo/GO_0071159	denotes	NF-κB complex
T3206	577-590	http://purl.obolibrary.org/obo/GO_0071159	denotes	NF-κB complex
T3207	859-872	http://purl.obolibrary.org/obo/GO_0071159	denotes	NF-κB complex
T3208	4310-4323	http://purl.obolibrary.org/obo/GO_0071159	denotes	NF-κB complex
T3209	880-887	http://purl.obolibrary.org/obo/GO_0005634	denotes	nucleus
T3210	1063-1073	http://purl.obolibrary.org/obo/GO_0000502	denotes	proteasome
T3211	1149-1152	http://purl.obolibrary.org/obo/GO_0005952	denotes	PKA
T3212	1956-1960	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T3213	2672-2676	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T3214	3293-3297	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T3215	3322-3326	http://purl.obolibrary.org/obo/GO_0005623	denotes	cell
T3216	3480-3485	http://purl.obolibrary.org/obo/GO_0005623	denotes	cells
T3217	2124-2129	http://purl.obolibrary.org/obo/GO_0018995	denotes	hosts
T3218	2667-2671	http://purl.obolibrary.org/obo/GO_0018995	denotes	host
T3219	2471-2485	http://purl.obolibrary.org/obo/GO_0019031	denotes	viral envelope
T3220	2477-2485	http://purl.obolibrary.org/obo/GO_0009274	denotes	envelope
T3221	2667-2676	http://purl.obolibrary.org/obo/GO_0043657	denotes	host cell

sentences

Id	Subject	Object	Predicate	Lexical cue
T1429	13-156	Sentence	denotes	Nuclear factor (NF)-κB transcription factors regulate the transcription of genes that are involved in the immune and inflammatory response (1).
T1430	157-338	Sentence	denotes	The NF-κB family includes RelA/p65, c-Rel, RelB, p50 and p52 that share a highly conserved 300-amino acid Rel homology domain (RHD) for homo- or hetero-dimerization and DNA-binding.
T1431	339-531	Sentence	denotes	The transcriptional activity of the NF-κB complex depends on dimer composition since C-terminal unrelated transcriptional activation domains are present exclusively in p65, RelB and c-Rel (2).
T1432	532-633	Sentence	denotes	Inhibitors of NF-κB (IκB) associate with the NF-κB complex and interfere with its binding to DNA (3).
T1433	634-888	Sentence	denotes	In the canonical pathway of NF-κB activation, the activated IκB kinase (IKK) phosphorylates IκB at specific serine residues that target the protein to ubiquitination and proteasomal degradation, which releases the functional NF-κB complex in the nucleus.
T1434	889-1078	Sentence	denotes	IκB-α, the most abundant inhibitor of NF-κB (4), is phosphorylated by IKK at Ser32 and Ser36 (5), and subsequently ubiquitylated at Lys21 and Lys22 to be degraded by the 26S proteasome (6).
T1435	1079-1215	Sentence	denotes	The NF-κB activity is enhanced by phosphorylation of p65 at Ser276 by PKA and MSK1 (7,8), Ser311 by PKCζ (9) and Ser536 by IKKα (10,11).
T1436	1216-1398	Sentence	denotes	Acetylation of p65 at Lys218 and Lys221 increases the DNA binding and impairs the association with IκB-α, and acetylation at Lys310 enhances the p65 transcriptional activity (12,13).
T1437	1399-1591	Sentence	denotes	Post-activation turn off of NF-κB is regulated by negative feedback loop through inhibitors under the transcriptional control of NF-κB, such as IκB-α and ubiquitin-editing protein A20 (14–20).
T1438	1592-1735	Sentence	denotes	Deacetylation of p65 by histone deacetylase-3 or SIRT1, or acetylation of p65 at Lys122 and Lys123 down-regulate the NF-κB activity (12,21,22).
T1439	1736-2003	Sentence	denotes	Persistent activation of NF-κB occurs in human immunodeficiency virus-1 (HIV-1)-infected monocytes, macrophages and microglia, and enhances the expression of NF-κB-responsive genes, including pro-inflammatory cytokines, cell adhesion molecules and chemokines (23–25).
T1440	2004-2091	Sentence	denotes	Chronic inflammation is a major cause of immune and neuron dysfunction in AIDS (26,27).
T1441	2092-2310	Sentence	denotes	Consistently, non-human primate hosts for simian immunodeficiency virus, such as African green monkeys and sooty mangabey, lack aberrant immune activation and do not develop AIDS despite high virus replication (28,29).
T1442	2311-2429	Sentence	denotes	Thus, understanding the mechanisms of NF-κB deregulation by HIV-1 may provide further insights into AIDS pathogenesis.
T1443	2430-2568	Sentence	denotes	In HIV-1 entry, the binding of the gp120 viral envelope to CD4 induces the NF-κB activity by activation of IKK (30) and procaspase 8 (31).
T1444	2569-2718	Sentence	denotes	Following viral integration, the early encoded HIV-1 Tat protein interacts with the HIV-1 RNA and host cell factors to sustain the viral replication.
T1445	2719-2968	Sentence	denotes	Tat binds to RNA stem-loop structures generated by the 5′ end of target transcripts, including the HIV-1 transactivation-responsive element (TAR) (32), tumor necrosis factor β (TNFβ) (33) and interleukin-6 (IL-6) (34) to activate gene transcription.
T1446	2969-3231	Sentence	denotes	Indeed, Tat promotes the transcriptional initiation and elongation by interacting with transacting factors and cofactors, such as Sp1 (35), TFIID (36), E2F-4 (37), C/EBPβ (38), cyclin T1/CDK9 (39,40) and the histone acetyltransferases p300/CBP and P/CAF (41–43).
T1447	3232-3414	Sentence	denotes	When released from HIV-1-infected cells, Tat deregulates the cell signaling by binding to cell receptors, such as integrins (44), Flk1/KDR receptor (45) and chemokine receptors (46).
T1448	3415-3526	Sentence	denotes	We first reported that NF-κB was constitutively active in Jurkat cells that stably expressed the Tat gene (47).
T1449	3527-3766	Sentence	denotes	Following gene transfection or protein transduction, Tat induced the IKK activity and proteasomal degradation of IκB-α (48), and increased the p65 transcriptional activity by inhibiting the SIRT-1-mediated deacetylation of p65 Lys310 (49).
T1450	3767-3998	Sentence	denotes	These findings suggested that Tat modulates crucial enzymes involved in NF-κB signaling; however, it was unclear how Tat could subvert the negative feedback of NF-κB, which is mainly dependent on de novo synthesis of IκB-α (15,17).
T1451	3999-4111	Sentence	denotes	We previously found that IκB-α binds to Tat and promotes the nuclear export of the viral transactivator (50,51).
T1452	4112-4324	Sentence	denotes	In this study, we report that Tat counteracts the post-activation turn off of NF-κB through direct interaction with IκB-α and p65, which enhances the DNA binding and transcriptional activity of the NF-κB complex.
T1453	4325-4463	Sentence	denotes	The new mechanism of NF-κB deregulation here described may provide further insights into the chronic immune activation of HIV-1 infection.
T10	0-12	Sentence	denotes	INTRODUCTION
T11	13-156	Sentence	denotes	Nuclear factor (NF)-κB transcription factors regulate the transcription of genes that are involved in the immune and inflammatory response (1).
T12	157-338	Sentence	denotes	The NF-κB family includes RelA/p65, c-Rel, RelB, p50 and p52 that share a highly conserved 300-amino acid Rel homology domain (RHD) for homo- or hetero-dimerization and DNA-binding.
T13	339-531	Sentence	denotes	The transcriptional activity of the NF-κB complex depends on dimer composition since C-terminal unrelated transcriptional activation domains are present exclusively in p65, RelB and c-Rel (2).
T14	532-633	Sentence	denotes	Inhibitors of NF-κB (IκB) associate with the NF-κB complex and interfere with its binding to DNA (3).
T15	634-888	Sentence	denotes	In the canonical pathway of NF-κB activation, the activated IκB kinase (IKK) phosphorylates IκB at specific serine residues that target the protein to ubiquitination and proteasomal degradation, which releases the functional NF-κB complex in the nucleus.
T16	889-1078	Sentence	denotes	IκB-α, the most abundant inhibitor of NF-κB (4), is phosphorylated by IKK at Ser32 and Ser36 (5), and subsequently ubiquitylated at Lys21 and Lys22 to be degraded by the 26S proteasome (6).
T17	1079-1215	Sentence	denotes	The NF-κB activity is enhanced by phosphorylation of p65 at Ser276 by PKA and MSK1 (7,8), Ser311 by PKCζ (9) and Ser536 by IKKα (10,11).
T18	1216-1398	Sentence	denotes	Acetylation of p65 at Lys218 and Lys221 increases the DNA binding and impairs the association with IκB-α, and acetylation at Lys310 enhances the p65 transcriptional activity (12,13).
T19	1399-1591	Sentence	denotes	Post-activation turn off of NF-κB is regulated by negative feedback loop through inhibitors under the transcriptional control of NF-κB, such as IκB-α and ubiquitin-editing protein A20 (14–20).
T20	1592-1735	Sentence	denotes	Deacetylation of p65 by histone deacetylase-3 or SIRT1, or acetylation of p65 at Lys122 and Lys123 down-regulate the NF-κB activity (12,21,22).
T21	1736-2003	Sentence	denotes	Persistent activation of NF-κB occurs in human immunodeficiency virus-1 (HIV-1)-infected monocytes, macrophages and microglia, and enhances the expression of NF-κB-responsive genes, including pro-inflammatory cytokines, cell adhesion molecules and chemokines (23–25).
T22	2004-2091	Sentence	denotes	Chronic inflammation is a major cause of immune and neuron dysfunction in AIDS (26,27).
T23	2092-2310	Sentence	denotes	Consistently, non-human primate hosts for simian immunodeficiency virus, such as African green monkeys and sooty mangabey, lack aberrant immune activation and do not develop AIDS despite high virus replication (28,29).
T24	2311-2429	Sentence	denotes	Thus, understanding the mechanisms of NF-κB deregulation by HIV-1 may provide further insights into AIDS pathogenesis.
T25	2430-2568	Sentence	denotes	In HIV-1 entry, the binding of the gp120 viral envelope to CD4 induces the NF-κB activity by activation of IKK (30) and procaspase 8 (31).
T26	2569-2718	Sentence	denotes	Following viral integration, the early encoded HIV-1 Tat protein interacts with the HIV-1 RNA and host cell factors to sustain the viral replication.
T27	2719-2968	Sentence	denotes	Tat binds to RNA stem-loop structures generated by the 5′ end of target transcripts, including the HIV-1 transactivation-responsive element (TAR) (32), tumor necrosis factor β (TNFβ) (33) and interleukin-6 (IL-6) (34) to activate gene transcription.
T28	2969-3231	Sentence	denotes	Indeed, Tat promotes the transcriptional initiation and elongation by interacting with transacting factors and cofactors, such as Sp1 (35), TFIID (36), E2F-4 (37), C/EBPβ (38), cyclin T1/CDK9 (39,40) and the histone acetyltransferases p300/CBP and P/CAF (41–43).
T29	3232-3414	Sentence	denotes	When released from HIV-1-infected cells, Tat deregulates the cell signaling by binding to cell receptors, such as integrins (44), Flk1/KDR receptor (45) and chemokine receptors (46).
T30	3415-3526	Sentence	denotes	We first reported that NF-κB was constitutively active in Jurkat cells that stably expressed the Tat gene (47).
T31	3527-3766	Sentence	denotes	Following gene transfection or protein transduction, Tat induced the IKK activity and proteasomal degradation of IκB-α (48), and increased the p65 transcriptional activity by inhibiting the SIRT-1-mediated deacetylation of p65 Lys310 (49).
T32	3767-3998	Sentence	denotes	These findings suggested that Tat modulates crucial enzymes involved in NF-κB signaling; however, it was unclear how Tat could subvert the negative feedback of NF-κB, which is mainly dependent on de novo synthesis of IκB-α (15,17).
T33	3999-4111	Sentence	denotes	We previously found that IκB-α binds to Tat and promotes the nuclear export of the viral transactivator (50,51).
T34	4112-4324	Sentence	denotes	In this study, we report that Tat counteracts the post-activation turn off of NF-κB through direct interaction with IκB-α and p65, which enhances the DNA binding and transcriptional activity of the NF-κB complex.
T35	4325-4463	Sentence	denotes	The new mechanism of NF-κB deregulation here described may provide further insights into the chronic immune activation of HIV-1 infection.

ICD10

Id	Subject	Object	Predicate	Lexical cue
T3222	1783-1799	http://purl.bioontology.org/ontology/ICD10/D84.9	denotes	immunodeficiency
T3223	2141-2157	http://purl.bioontology.org/ontology/ICD10/D84.9	denotes	immunodeficiency

events-check-again

Id	Subject	Object	Predicate	Lexical cue
T3998	183-187	Protein	denotes	RelA
T3999	188-191	Protein	denotes	p65
T4000	193-198	Protein	denotes	c-Rel
T4001	200-204	Protein	denotes	RelB
T4002	206-209	Protein	denotes	p50
T4003	214-217	Protein	denotes	p52
T4004	263-282	Entity	denotes	Rel homology domain
T4005	289-292	Positive_regulation	denotes	for
T4006	289-292	Positive_regulation	denotes	for
T4007	289-292	Positive_regulation	denotes	for
T4008	289-292	Positive_regulation	denotes	for
T4009	289-292	Positive_regulation	denotes	for
T4010	289-292	Positive_regulation	denotes	for
T4011	289-292	Positive_regulation	denotes	for
T4012	289-292	Positive_regulation	denotes	for
T4013	289-292	Positive_regulation	denotes	for
T4014	289-292	Positive_regulation	denotes	for
T4015	289-292	Positive_regulation	denotes	for
T4016	289-292	Positive_regulation	denotes	for
T4017	289-292	Positive_regulation	denotes	for
T4018	289-292	Positive_regulation	denotes	for
T4019	289-292	Positive_regulation	denotes	for
T4020	289-292	Positive_regulation	denotes	for
T4021	289-292	Positive_regulation	denotes	for
T4022	289-292	Positive_regulation	denotes	for
T4023	289-292	Positive_regulation	denotes	for
T4024	289-292	Positive_regulation	denotes	for
T4025	289-292	Positive_regulation	denotes	for
T4026	289-292	Positive_regulation	denotes	for
T4027	289-292	Positive_regulation	denotes	for
T4028	289-292	Positive_regulation	denotes	for
T4029	289-292	Positive_regulation	denotes	for
T4030	289-292	Positive_regulation	denotes	for
T4031	289-292	Positive_regulation	denotes	for
T4032	289-292	Positive_regulation	denotes	for
T4033	289-292	Positive_regulation	denotes	for
T4034	289-292	Positive_regulation	denotes	for
T4035	289-292	Positive_regulation	denotes	for
T4036	289-292	Positive_regulation	denotes	for
T4037	289-292	Positive_regulation	denotes	for
T4038	289-292	Positive_regulation	denotes	for
T4039	289-292	Positive_regulation	denotes	for
T4040	289-292	Positive_regulation	denotes	for
T4041	289-292	Positive_regulation	denotes	for
T4042	289-292	Positive_regulation	denotes	for
T4043	289-292	Positive_regulation	denotes	for
T4044	289-292	Positive_regulation	denotes	for
T4045	289-292	Positive_regulation	denotes	for
T4046	289-292	Positive_regulation	denotes	for
T4047	289-292	Positive_regulation	denotes	for
T4048	289-292	Positive_regulation	denotes	for
T4049	289-292	Positive_regulation	denotes	for
T4050	289-292	Positive_regulation	denotes	for
T4051	289-292	Positive_regulation	denotes	for
T4052	289-292	Positive_regulation	denotes	for
T4053	289-292	Positive_regulation	denotes	for
T4054	289-292	Positive_regulation	denotes	for
T4055	309-321	Binding	denotes	dimerization
T4056	309-321	Binding	denotes	dimerization
T4057	309-321	Binding	denotes	dimerization
T4058	309-321	Binding	denotes	dimerization
T4059	309-321	Binding	denotes	dimerization
T4060	330-337	Binding	denotes	binding
T4061	330-337	Binding	denotes	binding
T4062	330-337	Binding	denotes	binding
T4063	330-337	Binding	denotes	binding
T4064	330-337	Binding	denotes	binding
T4065	507-510	Protein	denotes	p65
T4066	512-516	Protein	denotes	RelB
T4067	521-526	Protein	denotes	c-Rel
T4068	889-894	Protein	denotes	IκB-α
T4069	941-955	Phosphorylation	denotes	phosphorylated
T4070	941-955	Phosphorylation	denotes	phosphorylated
T4071	966-971	Entity	denotes	Ser32
T4072	976-981	Entity	denotes	Ser36
T4073	1004-1017	Ubiquitination	denotes	ubiquitylated
T4074	1004-1017	Ubiquitination	denotes	ubiquitylated
T4075	1021-1026	Entity	denotes	Lys21
T4076	1031-1036	Entity	denotes	Lys22
T4077	1043-1051	Protein_catabolism	denotes	degraded
T4078	1052-1054	Positive_regulation	denotes	by
T4079	1113-1128	Phosphorylation	denotes	phosphorylation
T4080	1113-1128	Phosphorylation	denotes	phosphorylation
T4081	1113-1128	Phosphorylation	denotes	phosphorylation
T4082	1132-1135	Protein	denotes	p65
T4083	1139-1145	Entity	denotes	Ser276
T4084	1146-1148	Positive_regulation	denotes	by
T4085	1157-1161	Protein	denotes	MSK1
T4086	1169-1175	Entity	denotes	Ser311
T4087	1176-1178	Positive_regulation	denotes	by
T4088	1179-1183	Protein	denotes	PKCζ
T4089	1192-1198	Entity	denotes	Ser536
T4090	1199-1201	Positive_regulation	denotes	by
T4091	1202-1206	Protein	denotes	IKKα
T4092	1216-1227	Acetylation	denotes	Acetylation
T4093	1216-1227	Acetylation	denotes	Acetylation
T4094	1231-1234	Protein	denotes	p65
T4095	1238-1244	Entity	denotes	Lys218
T4096	1249-1255	Entity	denotes	Lys221
T4097	1256-1265	Positive_regulation	denotes	increases
T4098	1256-1265	Positive_regulation	denotes	increases
T4099	1274-1281	Binding	denotes	binding
T4100	1286-1293	Negative_regulation	denotes	impairs
T4101	1286-1293	Negative_regulation	denotes	impairs
T4102	1298-1309	Binding	denotes	association
T4103	1315-1320	Protein	denotes	IκB-α
T4104	1326-1337	Acetylation	denotes	acetylation
T4105	1341-1347	Entity	denotes	Lys310
T4106	1361-1364	Protein	denotes	p65
T4107	1543-1548	Protein	denotes	IκB-α
T4108	1579-1582	Protein	denotes	A20
T4109	1592-1605	Deacetylation	denotes	Deacetylation
T4110	1592-1605	Deacetylation	denotes	Deacetylation
T4111	1609-1612	Protein	denotes	p65
T4112	1616-1637	Protein	denotes	histone deacetylase-3
T4113	1641-1646	Protein	denotes	SIRT1
T4114	1651-1662	Deacetylation	denotes	acetylation
T4115	1651-1662	Deacetylation	denotes	acetylation
T4116	1666-1669	Protein	denotes	p65
T4117	1673-1679	Entity	denotes	Lys122
T4118	1684-1690	Entity	denotes	Lys123
T4119	2450-2457	Binding	denotes	binding
T4120	2465-2470	Protein	denotes	gp120
T4121	2489-2492	Protein	denotes	CD4
T4122	2493-2500	Positive_regulation	denotes	induces
T4123	2523-2533	Positive_regulation	denotes	activation
T4124	2550-2562	Protein	denotes	procaspase 8
T4125	2622-2625	Protein	denotes	Tat
T4126	2634-2643	Binding	denotes	interacts
T4127	2719-2722	Protein	denotes	Tat
T4128	2723-2728	Binding	denotes	binds
T4129	2871-2894	Protein	denotes	tumor necrosis factor β
T4130	2896-2900	Protein	denotes	TNFβ
T4131	2911-2924	Protein	denotes	interleukin-6
T4132	2926-2930	Protein	denotes	IL-6
T4133	2940-2948	Positive_regulation	denotes	activate
T4134	2940-2948	Positive_regulation	denotes	activate
T4135	2954-2967	Transcription	denotes	transcription
T4136	2954-2967	Transcription	denotes	transcription
T4137	2977-2980	Protein	denotes	Tat
T4138	3039-3050	Binding	denotes	interacting
T4139	3039-3050	Binding	denotes	interacting
T4140	3039-3050	Binding	denotes	interacting
T4141	3039-3050	Binding	denotes	interacting
T4142	3039-3050	Binding	denotes	interacting
T4143	3039-3050	Binding	denotes	interacting
T4144	3039-3050	Binding	denotes	interacting
T4145	3039-3050	Binding	denotes	interacting
T4146	3039-3050	Binding	denotes	interacting
T4147	3099-3102	Protein	denotes	Sp1
T4148	3109-3114	Protein	denotes	TFIID
T4149	3121-3126	Protein	denotes	E2F-4
T4150	3133-3139	Protein	denotes	C/EBPβ
T4151	3146-3155	Protein	denotes	cyclin T1
T4152	3156-3160	Protein	denotes	CDK9
T4153	3204-3208	Protein	denotes	p300
T4154	3209-3212	Protein	denotes	CBP
T4155	3217-3222	Protein	denotes	P/CAF
T4156	3237-3245	Localization	denotes	released
T4157	3273-3276	Protein	denotes	Tat
T4158	3311-3318	Binding	denotes	binding
T4159	3362-3379	Protein	denotes	Flk1/KDR receptor
T4160	3498-3507	Gene_expression	denotes	expressed
T4161	3512-3515	Protein	denotes	Tat
T4162	3580-3583	Protein	denotes	Tat
T4163	3584-3591	Positive_regulation	denotes	induced
T4164	3625-3636	Protein_catabolism	denotes	degradation
T4165	3640-3645	Protein	denotes	IκB-α
T4166	3670-3673	Protein	denotes	p65
T4167	3702-3712	Negative_regulation	denotes	inhibiting
T4168	3717-3723	Protein	denotes	SIRT-1
T4169	3724-3732	Positive_regulation	denotes	mediated
T4170	3733-3746	Deacetylation	denotes	deacetylation
T4171	3750-3753	Protein	denotes	p65
T4172	3754-3760	Entity	denotes	Lys310
T4173	3797-3800	Protein	denotes	Tat
T4174	3884-3887	Protein	denotes	Tat
T4175	3971-3980	Gene_expression	denotes	synthesis
T4176	3984-3989	Protein	denotes	IκB-α
T4177	4024-4029	Protein	denotes	IκB-α
T4178	4030-4035	Binding	denotes	binds
T4179	4039-4042	Protein	denotes	Tat
T4180	4142-4145	Protein	denotes	Tat
T4181	4211-4222	Binding	denotes	interaction
T4182	4228-4233	Protein	denotes	IκB-α
T4183	4238-4241	Protein	denotes	p65
R3990	T4127	T4128	themeOf	Tat,binds
R3633	T3998	T4057	themeOf	RelA,dimerization
R3636	T3998	T4062	themeOf	RelA,binding
R3639	T3999	T3998	equivalentTo	p65,RelA
R3640	T4000	T4056	themeOf	c-Rel,dimerization
R3641	T4000	T4060	themeOf	c-Rel,binding
R3643	T4001	T4059	themeOf	RelB,dimerization
R3644	T4001	T4061	themeOf	RelB,binding
R3646	T4002	T4063	themeOf	p50,binding
R3647	T4002	T4058	themeOf	p50,dimerization
R3648	T4003	T4064	themeOf	p52,binding
R3649	T4003	T4055	themeOf	p52,dimerization
R3652	T4004	T4032	causeOf	Rel homology domain,for
R3653	T4004	T4031	causeOf	Rel homology domain,for
R3654	T4004	T4030	causeOf	Rel homology domain,for
R3655	T4004	T4029	causeOf	Rel homology domain,for
R3656	T4004	T4028	causeOf	Rel homology domain,for
R3657	T4004	T4005	causeOf	Rel homology domain,for
R3658	T4004	T4025	causeOf	Rel homology domain,for
R3659	T4004	T4024	causeOf	Rel homology domain,for
R3660	T4004	T4023	causeOf	Rel homology domain,for
R3661	T4004	T4022	causeOf	Rel homology domain,for
R3662	T4004	T4020	causeOf	Rel homology domain,for
R3663	T4004	T4019	causeOf	Rel homology domain,for
R3664	T4004	T4018	causeOf	Rel homology domain,for
R3665	T4004	T4017	causeOf	Rel homology domain,for
R3666	T4004	T4012	causeOf	Rel homology domain,for
R3667	T4004	T3998	partOf	Rel homology domain,RelA
R3668	T4004	T4011	causeOf	Rel homology domain,for
R3669	T4004	T4000	partOf	Rel homology domain,c-Rel
R3670	T4004	T4010	causeOf	Rel homology domain,for
R3671	T4004	T4001	partOf	Rel homology domain,RelB
R3672	T4004	T4008	causeOf	Rel homology domain,for
R3673	T4004	T4002	partOf	Rel homology domain,p50
R3674	T4004	T4007	causeOf	Rel homology domain,for
R3675	T4004	T4003	partOf	Rel homology domain,p52
R3676	T4004	T4006	causeOf	Rel homology domain,for
R3677	T4004	T4026	causeOf	Rel homology domain,for
R3678	T4004	T4045	causeOf	Rel homology domain,for
R3679	T4004	T4054	causeOf	Rel homology domain,for
R3680	T4004	T4009	causeOf	Rel homology domain,for
R3681	T4004	T4013	causeOf	Rel homology domain,for
R3682	T4004	T4014	causeOf	Rel homology domain,for
R3683	T4004	T4015	causeOf	Rel homology domain,for
R3684	T4004	T4016	causeOf	Rel homology domain,for
R3685	T4004	T4021	causeOf	Rel homology domain,for
R3686	T4004	T4027	causeOf	Rel homology domain,for
R3687	T4004	T4033	causeOf	Rel homology domain,for
R3688	T4004	T4051	causeOf	Rel homology domain,for
R3689	T4004	T4039	causeOf	Rel homology domain,for
R3690	T4004	T4053	causeOf	Rel homology domain,for
R3691	T4004	T4052	causeOf	Rel homology domain,for
R3692	T4004	T4050	causeOf	Rel homology domain,for
R3693	T4004	T4049	causeOf	Rel homology domain,for
R3694	T4004	T4048	causeOf	Rel homology domain,for
R3695	T4004	T4047	causeOf	Rel homology domain,for
R3696	T4004	T4046	causeOf	Rel homology domain,for
R3697	T4004	T4044	causeOf	Rel homology domain,for
R3698	T4004	T4043	causeOf	Rel homology domain,for
R3699	T4004	T4042	causeOf	Rel homology domain,for
R3700	T4004	T4041	causeOf	Rel homology domain,for
R3701	T4004	T4040	causeOf	Rel homology domain,for
R3702	T4004	T4038	causeOf	Rel homology domain,for
R3703	T4004	T4037	causeOf	Rel homology domain,for
R3704	T4004	T4036	causeOf	Rel homology domain,for
R3705	T4004	T4035	causeOf	Rel homology domain,for
R3706	T4004	T4034	causeOf	Rel homology domain,for
R3707	T4055	T4052	themeOf	dimerization,for
R3708	T4055	T4050	themeOf	dimerization,for
R3709	T4055	T4049	themeOf	dimerization,for
R3710	T4055	T4048	themeOf	dimerization,for
R3711	T4055	T4047	themeOf	dimerization,for
R3712	T4056	T4006	themeOf	dimerization,for
R3713	T4056	T4026	themeOf	dimerization,for
R3714	T4056	T4045	themeOf	dimerization,for
R3715	T4056	T4054	themeOf	dimerization,for
R3716	T4056	T4009	themeOf	dimerization,for
R3717	T4057	T4012	themeOf	dimerization,for
R3718	T4057	T4011	themeOf	dimerization,for
R3719	T4057	T4010	themeOf	dimerization,for
R3720	T4057	T4008	themeOf	dimerization,for
R3721	T4057	T4007	themeOf	dimerization,for
R3722	T4058	T4027	themeOf	dimerization,for
R3723	T4058	T4033	themeOf	dimerization,for
R3724	T4058	T4051	themeOf	dimerization,for
R3725	T4152	T4143	themeOf	CDK9,interacting
R3726	T4058	T4039	themeOf	dimerization,for
R3727	T4153	T4144	themeOf	p300,interacting
R3728	T4058	T4053	themeOf	dimerization,for
R3729	T4154	T4146	themeOf	CBP,interacting
R3730	T4059	T4013	themeOf	dimerization,for
R3731	T4155	T4145	themeOf	P/CAF,interacting
R3732	T4157	T4156	themeOf	Tat,released
R3733	T4157	T4158	themeOf	Tat,binding
R3734	T4059	T4014	themeOf	dimerization,for
R3735	T4161	T4160	themeOf	Tat,expressed
R3736	T4059	T4015	themeOf	dimerization,for
R3737	T4162	T4163	causeOf	Tat,induced
R3738	T4162	T4167	causeOf	Tat,inhibiting
R3739	T4059	T4016	themeOf	dimerization,for
R3740	T4164	T4163	themeOf	degradation,induced
R3741	T4059	T4021	themeOf	dimerization,for
R3742	T4165	T4164	themeOf	IκB-α,degradation
R3743	T4060	T4040	themeOf	binding,for
R3744	T4168	T4169	causeOf	SIRT-1,mediated
R3745	T4060	T4038	themeOf	binding,for
R3746	T4169	T4167	themeOf	mediated,inhibiting
R3747	T4170	T4169	themeOf	deacetylation,mediated
R3748	T4060	T4037	themeOf	binding,for
R3749	T4060	T4036	themeOf	binding,for
R3750	T4172	T4170	themeOf	Lys310,deacetylation
R3751	T4172	T4171	partOf	Lys310,p65
R3752	T4060	T4035	themeOf	binding,for
R3753	T4061	T4032	themeOf	binding,for
R3754	T4176	T4175	themeOf	IκB-α,synthesis
R3755	T4061	T4031	themeOf	binding,for
R3756	T4177	T4178	themeOf	IκB-α,binds
R3757	T4061	T4030	themeOf	binding,for
R3758	T4179	T4178	themeOf	Tat,binds
R3759	T4061	T4029	themeOf	binding,for
R3760	T4180	T4181	themeOf	Tat,interaction
R3761	T4061	T4034	themeOf	binding,for
R3762	T4182	T4181	themeOf	IκB-α,interaction
R3763	T4062	T4046	themeOf	binding,for
R3764	T4062	T4044	themeOf	binding,for
R3765	T4062	T4043	themeOf	binding,for
R3766	T4062	T4042	themeOf	binding,for
R3767	T4062	T4041	themeOf	binding,for
R3768	T4063	T4028	themeOf	binding,for
R3769	T4063	T4005	themeOf	binding,for
R3770	T4063	T4025	themeOf	binding,for
R3771	T4063	T4024	themeOf	binding,for
R3772	T4063	T4023	themeOf	binding,for
R3773	T4064	T4022	themeOf	binding,for
R3774	T4064	T4020	themeOf	binding,for
R3775	T4064	T4019	themeOf	binding,for
R3777	T4064	T4018	themeOf	binding,for
R3778	T4064	T4017	themeOf	binding,for
R3779	T4068	T4077	themeOf	IκB-α,degraded
R3780	T4071	T4070	themeOf	Ser32,phosphorylated
R3787	T4071	T4068	partOf	Ser32,IκB-α
R3788	T4072	T4069	themeOf	Ser36,phosphorylated
R3790	T4072	T4068	partOf	Ser36,IκB-α
R3796	T4075	T4073	themeOf	Lys21,ubiquitylated
R3799	T4075	T4068	partOf	Lys21,IκB-α
R3801	T4076	T4074	themeOf	Lys22,ubiquitylated
R3802	T4076	T4068	partOf	Lys22,IκB-α
R3803	T4077	T4078	themeOf	degraded,by
R3806	T4079	T4084	themeOf	phosphorylation,by
R3809	T4079	T4087	themeOf	phosphorylation,by
R3810	T4079	T4090	themeOf	phosphorylation,by
R3814	T4083	T4079	themeOf	Ser276,phosphorylation
R3819	T4083	T4082	partOf	Ser276,p65
R3822	T4085	T4084	causeOf	MSK1,by
R3826	T4086	T4081	themeOf	Ser311,phosphorylation
R3829	T4086	T4082	partOf	Ser311,p65
R3831	T4088	T4087	causeOf	PKCζ,by
R3833	T4089	T4080	themeOf	Ser536,phosphorylation
R3840	T4089	T4082	partOf	Ser536,p65
R3841	T4091	T4090	causeOf	IKKα,by
R3844	T4092	T4098	causeOf	Acetylation,increases
R3846	T4092	T4100	causeOf	Acetylation,impairs
R3847	T4093	T4097	causeOf	Acetylation,increases
R3848	T4093	T4101	causeOf	Acetylation,impairs
R3849	T4094	T4099	themeOf	p65,binding
R3852	T4094	T4102	themeOf	p65,association
R3853	T4095	T4092	themeOf	Lys218,Acetylation
R3857	T4095	T4094	partOf	Lys218,p65
R3859	T4096	T4093	themeOf	Lys221,Acetylation
R3862	T4096	T4094	partOf	Lys221,p65
R3864	T4099	T4098	themeOf	binding,increases
R3881	T4099	T4097	themeOf	binding,increases
R3882	T4102	T4100	themeOf	association,impairs
R3884	T4102	T4101	themeOf	association,impairs
R3885	T4103	T4102	themeOf	IκB-α,association
R3886	T4105	T4104	themeOf	Lys310,acetylation
R3947	T4105	T4094	partOf	Lys310,p65
R3948	T4111	T4110	themeOf	p65,Deacetylation
R3949	T4111	T4109	themeOf	p65,Deacetylation
R3950	T4112	T4110	causeOf	histone deacetylase-3,Deacetylation
R3951	T4113	T4109	causeOf	SIRT1,Deacetylation
R3957	T4117	T4114	themeOf	Lys122,acetylation
R3959	T4117	T4116	partOf	Lys122,p65
R3967	T4118	T4115	themeOf	Lys123,acetylation
R3969	T4118	T4116	partOf	Lys123,p65
R3970	T4119	T4122	causeOf	binding,induces
R3973	T4120	T4119	themeOf	gp120,binding
R3974	T4121	T4119	themeOf	CD4,binding
R3975	T4123	T4122	themeOf	activation,induces
R3979	T4124	T4123	themeOf	procaspase 8,activation
R3987	T4125	T4126	themeOf	Tat,interacts
R3992	T4128	T4134	causeOf	binds,activate
R3993	T4128	T4133	causeOf	binds,activate
R3994	T4129	T4135	themeOf	tumor necrosis factor β,transcription
R3995	T4130	T4129	equivalentTo	TNFβ,tumor necrosis factor β
R3996	T4131	T4136	themeOf	interleukin-6,transcription
R3997	T4132	T4131	equivalentTo	IL-6,interleukin-6
R3998	T4135	T4134	themeOf	transcription,activate
R3999	T4136	T4133	themeOf	transcription,activate
R4000	T4137	T4139	themeOf	Tat,interacting
R4001	T4137	T4141	themeOf	Tat,interacting
R4002	T4137	T4140	themeOf	Tat,interacting
R4003	T4137	T4138	themeOf	Tat,interacting
R4004	T4137	T4142	themeOf	Tat,interacting
R4005	T4137	T4143	themeOf	Tat,interacting
R4006	T4137	T4144	themeOf	Tat,interacting
R4007	T4137	T4146	themeOf	Tat,interacting
R4008	T4137	T4145	themeOf	Tat,interacting
R4009	T4147	T4139	themeOf	Sp1,interacting
R4010	T4148	T4141	themeOf	TFIID,interacting
R4011	T4149	T4140	themeOf	E2F-4,interacting
R4012	T4150	T4138	themeOf	C/EBPβ,interacting
R4013	T4151	T4142	themeOf	cyclin T1,interacting

bionlp-st-ge-2016-reference-tees

Id	Subject	Object	Predicate	Lexical cue
T4184	33-35	Protein	denotes	κB
T4185	58-66	Regulation	denotes	regulate
T4186	161-173	Protein	denotes	NF-κB family
T4187	183-187	Protein	denotes	RelA
T4188	188-191	Protein	denotes	p65
T4189	193-198	Protein	denotes	c-Rel
T4190	200-204	Protein	denotes	RelB
T4191	206-209	Protein	denotes	p50
T4192	214-217	Protein	denotes	p52
T4193	375-388	Protein	denotes	NF-κB complex
T4194	507-510	Protein	denotes	p65
T4195	512-516	Protein	denotes	RelB
T4196	546-551	Protein	denotes	NF-κB
T4197	553-556	Protein	denotes	IκB
T4198	577-582	Protein	denotes	NF-κB
T4199	532-542	Negative_regulation	denotes	Inhibitors
T4200	532-542	Negative_regulation	denotes	Inhibitors
T4201	558-567	Binding	denotes	associate
T4202	614-621	Binding	denotes	binding
T4203	614-621	Binding	denotes	binding
T4204	662-667	Protein	denotes	NF-κB
T4205	694-704	Protein	denotes	IκB kinase
T4206	706-709	Protein	denotes	IKK
T4207	726-729	Protein	denotes	IκB
T4208	859-864	Protein	denotes	NF-κB
T4209	668-678	Positive_regulation	denotes	activation
T4210	684-693	Positive_regulation	denotes	activated
T4211	684-693	Positive_regulation	denotes	activated
T4212	711-725	Phosphorylation	denotes	phosphorylates
T4213	711-725	Phosphorylation	denotes	phosphorylates
T4214	711-725	Phosphorylation	denotes	phosphorylates
T4215	816-827	Protein_catabolism	denotes	degradation
T4216	816-827	Protein_catabolism	denotes	degradation
T4217	835-843	Positive_regulation	denotes	releases
T4218	835-843	Positive_regulation	denotes	releases
T4219	865-872	Binding	denotes	complex
T4220	763-769	Regulation	denotes	target
T4221	763-769	Regulation	denotes	target
T4222	889-894	Protein	denotes	IκB-α
T4223	927-932	Protein	denotes	NF-κB
T4224	959-962	Protein	denotes	IKK
T4225	914-923	Negative_regulation	denotes	inhibitor
T4226	914-923	Negative_regulation	denotes	inhibitor
T4227	976-981	Entity	denotes	Ser36
T4228	1043-1051	Protein_catabolism	denotes	degraded
T4229	941-955	Phosphorylation	denotes	phosphorylated
T4230	941-955	Phosphorylation	denotes	phosphorylated
T4231	1083-1088	Protein	denotes	NF-κB
T4232	1132-1135	Protein	denotes	p65
T4233	1149-1152	Protein	denotes	PKA
T4234	1157-1161	Protein	denotes	MSK1
T4235	1101-1109	Positive_regulation	denotes	enhanced
T4236	1101-1109	Positive_regulation	denotes	enhanced
T4237	1113-1128	Phosphorylation	denotes	phosphorylation
T4238	1101-1109	Positive_regulation	denotes	enhanced
T4239	1231-1234	Protein	denotes	p65
T4240	1238-1244	Protein	denotes	Lys218
T4241	1249-1255	Protein	denotes	Lys221
T4242	1315-1320	Protein	denotes	IκB-α
T4243	1361-1364	Protein	denotes	p65
T4244	1216-1227	Negative_regulation	denotes	Acetylation
T4245	1216-1227	Negative_regulation	denotes	Acetylation
T4246	1216-1227	Negative_regulation	denotes	Acetylation
T4247	1298-1309	Binding	denotes	association
T4248	1348-1356	Positive_regulation	denotes	enhances
T4249	1427-1432	Protein	denotes	NF-κB
T4250	1528-1533	Protein	denotes	NF-κB
T4251	1543-1548	Protein	denotes	IκB-α
T4252	1553-1562	Protein	denotes	ubiquitin
T4253	1399-1414	Positive_regulation	denotes	Post-activation
T4254	1436-1445	Regulation	denotes	regulated
T4255	1517-1524	Regulation	denotes	control
T4256	1609-1612	Protein	denotes	p65
T4257	1616-1637	Protein	denotes	histone deacetylase-3
T4258	1641-1646	Protein	denotes	SIRT1
T4259	1666-1669	Protein	denotes	p65
T4260	1709-1714	Protein	denotes	NF-κB
T4261	1691-1704	Negative_regulation	denotes	down-regulate
T4262	1761-1766	Protein	denotes	NF-κB
T4263	1894-1899	Protein	denotes	NF-κB
T4264	1747-1757	Positive_regulation	denotes	activation
T4265	1880-1890	Gene_expression	denotes	expression
T4266	1867-1875	Positive_regulation	denotes	enhances
T4267	2349-2354	Protein	denotes	NF-κB
T4268	2465-2485	Protein	denotes	gp120 viral envelope
T4269	2489-2492	Protein	denotes	CD4
T4270	2505-2510	Protein	denotes	NF-κB
T4271	2450-2457	Binding	denotes	binding
T4272	2493-2500	Positive_regulation	denotes	induces
T4273	2602-2633	Protein	denotes	early encoded HIV-1 Tat protein
T4274	2634-2643	Binding	denotes	interacts
T4275	2719-2722	Protein	denotes	Tat
T4276	2871-2894	Protein	denotes	tumor necrosis factor β
T4277	2896-2900	Protein	denotes	TNFβ
T4278	2911-2924	Protein	denotes	interleukin-6
T4279	2926-2930	Protein	denotes	IL-6
T4280	2723-2728	Binding	denotes	binds
T4281	2723-2728	Binding	denotes	binds
T4282	2723-2728	Binding	denotes	binds
T4283	2723-2728	Binding	denotes	binds
T4284	2723-2728	Binding	denotes	binds
T4285	2723-2728	Binding	denotes	binds
T4286	2723-2728	Binding	denotes	binds
T4287	2977-2980	Protein	denotes	Tat
T4288	3099-3114	Protein	denotes	Sp1 (35), TFIID
T4289	3121-3126	Protein	denotes	E2F-4
T4290	3133-3139	Protein	denotes	C/EBPβ
T4291	3146-3160	Protein	denotes	cyclin T1/CDK9
T4292	3177-3203	Protein	denotes	histone acetyltransferases
T4293	3204-3208	Protein	denotes	p300
T4294	3209-3212	Protein	denotes	CBP
T4295	3039-3050	Binding	denotes	interacting
T4296	3039-3050	Binding	denotes	interacting
T4297	3039-3050	Binding	denotes	interacting
T4298	3039-3050	Binding	denotes	interacting
T4299	3039-3050	Binding	denotes	interacting
T4300	3039-3050	Binding	denotes	interacting
T4301	3039-3050	Binding	denotes	interacting
T4302	3039-3050	Binding	denotes	interacting
T4303	3039-3050	Binding	denotes	interacting
T4304	3039-3050	Binding	denotes	interacting
T4305	3039-3050	Binding	denotes	interacting
T4306	3039-3050	Binding	denotes	interacting
T4307	3039-3050	Binding	denotes	interacting
T4308	3039-3050	Binding	denotes	interacting
T4309	3039-3050	Binding	denotes	interacting
T4310	3039-3050	Binding	denotes	interacting
T4311	3039-3050	Binding	denotes	interacting
T4312	3039-3050	Binding	denotes	interacting
T4313	3039-3050	Binding	denotes	interacting
T4314	3039-3050	Binding	denotes	interacting
T4315	3039-3050	Binding	denotes	interacting
T4316	3273-3276	Protein	denotes	Tat
T4317	3362-3366	Protein	denotes	Flk1
T4318	3367-3370	Protein	denotes	KDR
T4319	3311-3318	Binding	denotes	binding
T4320	3311-3318	Binding	denotes	binding
T4321	3311-3318	Binding	denotes	binding
T4322	3438-3443	Protein	denotes	NF-κB
T4323	3512-3515	Protein	denotes	Tat
T4324	3498-3507	Gene_expression	denotes	expressed
T4325	3580-3583	Protein	denotes	Tat
T4326	3596-3599	Protein	denotes	IKK
T4327	3640-3645	Protein	denotes	IκB-α
T4328	3670-3673	Protein	denotes	p65
T4329	3717-3723	Protein	denotes	SIRT-1
T4330	3750-3760	Protein	denotes	p65 Lys310
T4331	3584-3591	Positive_regulation	denotes	induced
T4332	3625-3636	Protein_catabolism	denotes	degradation
T4333	3625-3636	Protein_catabolism	denotes	degradation
T4334	3656-3665	Positive_regulation	denotes	increased
T4335	3584-3591	Positive_regulation	denotes	induced
T4336	3584-3591	Positive_regulation	denotes	induced
T4337	3839-3844	Protein	denotes	NF-κB
T4338	3884-3887	Protein	denotes	Tat
T4339	3927-3932	Protein	denotes	NF-κB
T4340	3984-3989	Protein	denotes	IκB-α
T4341	3971-3980	Gene_expression	denotes	synthesis
T4342	4024-4029	Protein	denotes	IκB-α
T4343	4039-4042	Protein	denotes	Tat
T4344	4030-4035	Binding	denotes	binds
T4345	4142-4145	Protein	denotes	Tat
T4346	4190-4195	Protein	denotes	NF-κB
T4347	4228-4233	Protein	denotes	IκB-α
T4348	4238-4241	Protein	denotes	p65
T4349	4310-4323	Protein	denotes	NF-κB complex
T4350	4146-4157	Binding	denotes	counteracts
T4351	4211-4222	Binding	denotes	interaction
T4352	4211-4222	Binding	denotes	interaction
T4353	4266-4273	Binding	denotes	binding
T4354	4249-4257	Positive_regulation	denotes	enhances
T4355	4249-4257	Positive_regulation	denotes	enhances
T4356	4346-4351	Protein	denotes	NF-κB
T4357	4352-4364	Regulation	denotes	deregulation
R3988	T4353	T4354	themeOf	binding,enhances
R3989	T4353	T4355	themeOf	binding,enhances
R3991	T4356	T4357	themeOf	NF-κB,deregulation
R3776	T4184	T4185	themeOf	κB,regulate
R3781	T4196	T4199	themeOf	NF-κB,Inhibitors
R3782	T4196	T4201	themeOf	NF-κB,associate
R3783	T4196	T4202	themeOf	NF-κB,binding
R3784	T4197	T4200	themeOf	IκB,Inhibitors
R3785	T4197	T4203	themeOf	IκB,binding
R3786	T4198	T4201	themeOf	NF-κB,associate
R3789	T4204	T4209	themeOf	NF-κB,activation
R3791	T4205	T4210	themeOf	IκB kinase,activated
R3792	T4205	T4212	themeOf	IκB kinase,phosphorylates
R3793	T4206	T4211	themeOf	IKK,activated
R3794	T4206	T4213	themeOf	IKK,phosphorylates
R3795	T4206	T4215	themeOf	IKK,degradation
R3797	T4207	T4214	themeOf	IκB,phosphorylates
R3798	T4207	T4216	themeOf	IκB,degradation
R3800	T4208	T4219	themeOf	NF-κB,complex
R3804	T4215	T4217	themeOf	degradation,releases
R3805	T4215	T4220	themeOf	degradation,target
R3807	T4216	T4218	themeOf	degradation,releases
R3808	T4216	T4221	themeOf	degradation,target
R3811	T4222	T4225	themeOf	IκB-α,inhibitor
R3812	T4222	T4228	themeOf	IκB-α,degraded
R3813	T4222	T4229	themeOf	IκB-α,phosphorylated
R3815	T4222	T4227	partOf	IκB-α,Ser36
R3816	T4223	T4226	themeOf	NF-κB,inhibitor
R3817	T4224	T4230	themeOf	IKK,phosphorylated
R3818	T4224	T4227	partOf	IKK,Ser36
R3820	T4227	T4229	Site	Ser36,phosphorylated
R3821	T4227	T4230	Site	Ser36,phosphorylated
R3823	T4231	T4235	themeOf	NF-κB,enhanced
R3824	T4231	T4236	themeOf	NF-κB,enhanced
R3825	T4231	T4238	themeOf	NF-κB,enhanced
R3827	T4232	T4237	themeOf	p65,phosphorylation
R3828	T4233	T4235	causeOf	PKA,enhanced
R3830	T4234	T4236	causeOf	MSK1,enhanced
R3832	T4237	T4238	causeOf	phosphorylation,enhanced
R3834	T4239	T4244	themeOf	p65,Acetylation
R3835	T4239	T4247	themeOf	p65,association
R3836	T4240	T4245	themeOf	Lys218,Acetylation
R3837	T4241	T4246	themeOf	Lys221,Acetylation
R3838	T4242	T4247	themeOf	IκB-α,association
R3839	T4243	T4248	themeOf	p65,enhances
R3842	T4249	T4253	themeOf	NF-κB,Post-activation
R3843	T4250	T4255	themeOf	NF-κB,control
R3845	T4253	T4254	themeOf	Post-activation,regulated
R3850	T4259	T4261	causeOf	p65,down-regulate
R3851	T4260	T4261	themeOf	NF-κB,down-regulate
R3854	T4262	T4264	themeOf	NF-κB,activation
R3855	T4263	T4265	themeOf	NF-κB,expression
R3856	T4264	T4266	causeOf	activation,enhances
R3858	T4265	T4266	themeOf	expression,enhances
R3860	T4268	T4271	themeOf	gp120 viral envelope,binding
R3861	T4269	T4271	themeOf	CD4,binding
R3863	T4270	T4272	themeOf	NF-κB,induces
R3865	T4271	T4272	causeOf	binding,induces
R3866	T4273	T4274	themeOf	early encoded HIV-1 Tat protein,interacts
R3867	T4275	T4280	themeOf	Tat,binds
R3868	T4275	T4281	themeOf	Tat,binds
R3869	T4275	T4282	themeOf	Tat,binds
R3870	T4275	T4283	themeOf	Tat,binds
R3871	T4275	T4284	themeOf	Tat,binds
R3872	T4275	T4285	themeOf	Tat,binds
R3873	T4275	T4286	themeOf	Tat,binds
R3874	T4276	T4281	themeOf	tumor necrosis factor β,binds
R3875	T4277	T4282	themeOf	TNFβ,binds
R3876	T4277	T4285	themeOf	TNFβ,binds
R3877	T4277	T4286	themeOf	TNFβ,binds
R3878	T4278	T4283	themeOf	interleukin-6,binds
R3879	T4278	T4285	themeOf	interleukin-6,binds
R3880	T4279	T4284	themeOf	IL-6,binds
R3883	T4279	T4286	themeOf	IL-6,binds
R3887	T4287	T4295	themeOf	Tat,interacting
R3888	T4287	T4296	themeOf	Tat,interacting
R3889	T4287	T4297	themeOf	Tat,interacting
R3890	T4287	T4298	themeOf	Tat,interacting
R3891	T4287	T4299	themeOf	Tat,interacting
R3892	T4287	T4300	themeOf	Tat,interacting
R3893	T4287	T4301	themeOf	Tat,interacting
R3894	T4287	T4302	themeOf	Tat,interacting
R3895	T4287	T4303	themeOf	Tat,interacting
R3896	T4287	T4304	themeOf	Tat,interacting
R3897	T4287	T4305	themeOf	Tat,interacting
R3898	T4287	T4306	themeOf	Tat,interacting
R3899	T4287	T4307	themeOf	Tat,interacting
R3900	T4287	T4308	themeOf	Tat,interacting
R3901	T4287	T4309	themeOf	Tat,interacting
R3902	T4287	T4310	themeOf	Tat,interacting
R3903	T4287	T4311	themeOf	Tat,interacting
R3904	T4287	T4312	themeOf	Tat,interacting
R3905	T4287	T4313	themeOf	Tat,interacting
R3906	T4287	T4314	themeOf	Tat,interacting
R3907	T4287	T4315	themeOf	Tat,interacting
R3908	T4289	T4295	themeOf	E2F-4,interacting
R3909	T4289	T4301	themeOf	E2F-4,interacting
R3910	T4289	T4302	themeOf	E2F-4,interacting
R3911	T4289	T4303	themeOf	E2F-4,interacting
R3912	T4290	T4296	themeOf	C/EBPβ,interacting
R3913	T4290	T4304	themeOf	C/EBPβ,interacting
R3914	T4290	T4305	themeOf	C/EBPβ,interacting
R3915	T4290	T4306	themeOf	C/EBPβ,interacting
R3916	T4290	T4313	themeOf	C/EBPβ,interacting
R3917	T4291	T4297	themeOf	cyclin T1/CDK9,interacting
R3918	T4291	T4307	themeOf	cyclin T1/CDK9,interacting
R3919	T4291	T4308	themeOf	cyclin T1/CDK9,interacting
R3920	T4291	T4309	themeOf	cyclin T1/CDK9,interacting
R3921	T4291	T4314	themeOf	cyclin T1/CDK9,interacting
R3922	T4292	T4298	themeOf	histone acetyltransferases,interacting
R3923	T4292	T4301	themeOf	histone acetyltransferases,interacting
R3924	T4292	T4304	themeOf	histone acetyltransferases,interacting
R3925	T4292	T4307	themeOf	histone acetyltransferases,interacting
R3926	T4292	T4310	themeOf	histone acetyltransferases,interacting
R3927	T4292	T4311	themeOf	histone acetyltransferases,interacting
R3928	T4292	T4313	themeOf	histone acetyltransferases,interacting
R3929	T4292	T4314	themeOf	histone acetyltransferases,interacting
R3930	T4292	T4315	themeOf	histone acetyltransferases,interacting
R3931	T4293	T4299	themeOf	p300,interacting
R3932	T4293	T4302	themeOf	p300,interacting
R3933	T4293	T4305	themeOf	p300,interacting
R3934	T4293	T4308	themeOf	p300,interacting
R3935	T4293	T4310	themeOf	p300,interacting
R3936	T4293	T4312	themeOf	p300,interacting
R3937	T4293	T4313	themeOf	p300,interacting
R3938	T4293	T4314	themeOf	p300,interacting
R3939	T4293	T4315	themeOf	p300,interacting
R3940	T4294	T4300	themeOf	CBP,interacting
R3941	T4294	T4303	themeOf	CBP,interacting
R3942	T4294	T4306	themeOf	CBP,interacting
R3943	T4294	T4309	themeOf	CBP,interacting
R3944	T4294	T4311	themeOf	CBP,interacting
R3945	T4294	T4312	themeOf	CBP,interacting
R3946	T4294	T4315	themeOf	CBP,interacting
R3952	T4316	T4319	themeOf	Tat,binding
R3953	T4316	T4320	themeOf	Tat,binding
R3954	T4316	T4321	themeOf	Tat,binding
R3955	T4317	T4320	themeOf	Flk1,binding
R3956	T4318	T4321	themeOf	KDR,binding
R3958	T4323	T4324	themeOf	Tat,expressed
R3960	T4325	T4331	causeOf	Tat,induced
R3961	T4325	T4334	causeOf	Tat,increased
R3962	T4325	T4335	causeOf	Tat,induced
R3963	T4325	T4336	causeOf	Tat,induced
R3964	T4326	T4331	themeOf	IKK,induced
R3965	T4326	T4332	themeOf	IKK,degradation
R3966	T4327	T4333	themeOf	IκB-α,degradation
R3968	T4328	T4334	themeOf	p65,increased
R3971	T4332	T4335	themeOf	degradation,induced
R3972	T4333	T4336	themeOf	degradation,induced
R3976	T4340	T4341	themeOf	IκB-α,synthesis
R3977	T4342	T4344	themeOf	IκB-α,binds
R3978	T4343	T4344	themeOf	Tat,binds
R3980	T4345	T4350	themeOf	Tat,counteracts
R3981	T4346	T4350	themeOf	NF-κB,counteracts
R3982	T4347	T4351	themeOf	IκB-α,interaction
R3983	T4347	T4354	causeOf	IκB-α,enhances
R3984	T4348	T4352	themeOf	p65,interaction
R3985	T4348	T4355	causeOf	p65,enhances
R3986	T4349	T4353	themeOf	NF-κB complex,binding

test2

Id	Subject	Object	Predicate	Lexical cue
T1138	183-187	Protein	denotes	RelA
T1139	188-191	Protein	denotes	p65
T1140	193-198	Protein	denotes	c-Rel
T1141	200-204	Protein	denotes	RelB
T1142	206-209	Protein	denotes	p50
T1143	214-217	Protein	denotes	p52
T1144	263-282	Entity	denotes	Rel homology domain
T1145	330-337	Binding	denotes	binding
T1146	507-510	Protein	denotes	p65
T1147	512-516	Protein	denotes	RelB
T1148	521-526	Protein	denotes	c-Rel
T1149	614-621	Binding	denotes	binding
T1150	889-894	Protein	denotes	IκB-α
T1151	941-955	Phosphorylation	denotes	phosphorylated
T1152	966-971	Entity	denotes	Ser32
T1153	976-981	Entity	denotes	Ser36
T1154	1004-1017	Positive_regulation	denotes	ubiquitylated
T1155	1021-1026	Entity	denotes	Lys21
T1156	1031-1036	Entity	denotes	Lys22
T1157	1043-1051	Protein_catabolism	denotes	degraded
T1158	1101-1109	Positive_regulation	denotes	enhanced
T1159	1113-1128	Phosphorylation	denotes	phosphorylation
T1160	1132-1135	Protein	denotes	p65
T1161	1139-1145	Entity	denotes	Ser276
T1162	1157-1161	Protein	denotes	MSK1
T1163	1179-1183	Protein	denotes	PKCζ
T1164	1192-1198	Entity	denotes	Ser536
T1165	1202-1206	Protein	denotes	IKKα
T1166	1216-1227	Phosphorylation	denotes	Acetylation
T1167	1231-1234	Protein	denotes	p65
T1168	1238-1244	Entity	denotes	Lys218
T1169	1256-1265	Positive_regulation	denotes	increases
T1170	1274-1281	Binding	denotes	binding
T1171	1286-1293	Negative_regulation	denotes	impairs
T1172	1298-1309	Binding	denotes	association
T1173	1315-1320	Protein	denotes	IκB-α
T1174	1348-1356	Positive_regulation	denotes	enhances
T1175	1361-1364	Protein	denotes	p65
T1176	1365-1380	Transcription	denotes	transcriptional
T1177	1543-1548	Protein	denotes	IκB-α
T1178	1579-1582	Protein	denotes	A20
T1179	1592-1605	Negative_regulation	denotes	Deacetylation
T1180	1609-1612	Protein	denotes	p65
T1181	1616-1637	Protein	denotes	histone deacetylase-3
T1182	1641-1646	Protein	denotes	SIRT1
T1183	1651-1662	Phosphorylation	denotes	acetylation
T1184	1666-1669	Protein	denotes	p65
T1185	1673-1679	Entity	denotes	Lys122
T1186	1684-1690	Entity	denotes	Lys123
T1187	2465-2470	Protein	denotes	gp120
T1188	2489-2492	Protein	denotes	CD4
T1189	2523-2533	Positive_regulation	denotes	activation
T1190	2550-2562	Protein	denotes	procaspase 8
T1191	2622-2625	Protein	denotes	Tat
T1192	2634-2643	Binding	denotes	interacts
T1193	2719-2722	Protein	denotes	Tat
T1194	2723-2728	Binding	denotes	binds
T1195	2871-2894	Protein	denotes	tumor necrosis factor β
T1196	2896-2900	Protein	denotes	TNFβ
T1197	2911-2924	Protein	denotes	interleukin-6
T1198	2926-2930	Protein	denotes	IL-6
T1199	2977-2980	Protein	denotes	Tat
T1200	3039-3050	Binding	denotes	interacting
T1201	3099-3102	Protein	denotes	Sp1
T1202	3109-3114	Protein	denotes	TFIID
T1203	3121-3126	Protein	denotes	E2F-4
T1204	3133-3139	Protein	denotes	C/EBPβ
T1205	3146-3155	Protein	denotes	cyclin T1
T1206	3156-3160	Protein	denotes	CDK9
T1207	3204-3208	Protein	denotes	p300
T1208	3209-3212	Protein	denotes	CBP
T1209	3217-3222	Protein	denotes	P/CAF
T1210	3273-3276	Protein	denotes	Tat
T1211	3311-3318	Binding	denotes	binding
T1212	3362-3379	Protein	denotes	Flk1/KDR receptor
T1213	3498-3507	Gene_expression	denotes	expressed
T1214	3512-3515	Protein	denotes	Tat
T1215	3580-3583	Protein	denotes	Tat
T1216	3584-3591	Positive_regulation	denotes	induced
T1217	3625-3636	Protein_catabolism	denotes	degradation
T1218	3640-3645	Protein	denotes	IκB-α
T1219	3656-3665	Positive_regulation	denotes	increased
T1220	3670-3673	Protein	denotes	p65
T1221	3674-3689	Transcription	denotes	transcriptional
T1222	3702-3712	Negative_regulation	denotes	inhibiting
T1223	3717-3723	Protein	denotes	SIRT-1
T1224	3724-3732	Positive_regulation	denotes	mediated
T1225	3733-3746	Negative_regulation	denotes	deacetylation
T1226	3750-3753	Protein	denotes	p65
T1227	3797-3800	Protein	denotes	Tat
T1228	3884-3887	Protein	denotes	Tat
T1229	3950-3959	Regulation	denotes	dependent
T1230	3971-3980	Gene_expression	denotes	synthesis
T1231	3984-3989	Protein	denotes	IκB-α
T1232	4024-4029	Protein	denotes	IκB-α
T1233	4030-4035	Binding	denotes	binds
T1234	4039-4042	Protein	denotes	Tat
T1235	4047-4055	Positive_regulation	denotes	promotes
T1236	4060-4067	Entity	denotes	nuclear
T1237	4068-4074	Localization	denotes	export
T1238	4142-4145	Protein	denotes	Tat
T1239	4211-4222	Binding	denotes	interaction
T1240	4228-4233	Protein	denotes	IκB-α
T1241	4238-4241	Protein	denotes	p65
T1242	4266-4273	Binding	denotes	binding
R974	T1138	T1145	themeOf	RelA,binding
R975	T1139	T1145	themeOf	p65,binding
R976	T1139	T1138	equivalentTo	p65,RelA
R977	T1140	T1145	themeOf	c-Rel,binding
R978	T1141	T1145	themeOf	RelB,binding
R979	T1142	T1145	themeOf	p50,binding
R980	T1143	T1145	themeOf	p52,binding
R981	T1144	T1143	partOf	Rel homology domain,p52
R982	T1144	T1142	partOf	Rel homology domain,p50
R983	T1144	T1138	partOf	Rel homology domain,RelA
R984	T1144	T1139	partOf	Rel homology domain,p65
R985	T1144	T1140	partOf	Rel homology domain,c-Rel
R986	T1144	T1141	partOf	Rel homology domain,RelB
R987	T1150	T1157	themeOf	IκB-α,degraded
R988	T1150	T1151	themeOf	IκB-α,phosphorylated
R989	T1152	T1150	partOf	Ser32,IκB-α
R990	T1152	T1151	themeOf	Ser32,phosphorylated
R991	T1153	T1151	themeOf	Ser36,phosphorylated
R992	T1153	T1150	partOf	Ser36,IκB-α
R993	T1155	T1150	partOf	Lys21,IκB-α
R994	T1155	T1154	themeOf	Lys21,ubiquitylated
R995	T1156	T1154	themeOf	Lys22,ubiquitylated
R996	T1156	T1150	partOf	Lys22,IκB-α
R997	T1161	T1159	themeOf	Ser276,phosphorylation
R998	T1161	T1160	partOf	Ser276,p65
R999	T1164	T1160	partOf	Ser536,p65
R1000	T1164	T1163	partOf	Ser536,PKCζ
R1001	T1166	T1174	causeOf	Acetylation,enhances
R1002	T1167	T1166	themeOf	p65,Acetylation
R1003	T1167	T1170	themeOf	p65,binding
R1004	T1168	T1167	partOf	Lys218,p65
R1005	T1168	T1166	themeOf	Lys218,Acetylation
R1006	T1172	T1171	themeOf	association,impairs
R1007	T1173	T1172	themeOf	IκB-α,association
R1008	T1175	T1176	themeOf	p65,transcriptional
R1009	T1176	T1174	themeOf	transcriptional,enhances
R1010	T1180	T1179	themeOf	p65,Deacetylation
R1011	T1181	T1179	causeOf	histone deacetylase-3,Deacetylation
R1012	T1182	T1179	causeOf	SIRT1,Deacetylation
R1013	T1185	T1184	partOf	Lys122,p65
R1014	T1185	T1183	themeOf	Lys122,acetylation
R1015	T1186	T1183	themeOf	Lys123,acetylation
R1016	T1186	T1184	partOf	Lys123,p65
R1017	T1190	T1189	themeOf	procaspase 8,activation
R1018	T1191	T1192	themeOf	Tat,interacts
R1019	T1193	T1194	themeOf	Tat,binds
R1020	T1196	T1195	equivalentTo	TNFβ,tumor necrosis factor β
R1021	T1198	T1197	equivalentTo	IL-6,interleukin-6
R1022	T1199	T1200	themeOf	Tat,interacting
R1023	T1201	T1200	themeOf	Sp1,interacting
R1024	T1202	T1200	themeOf	TFIID,interacting
R1025	T1203	T1200	themeOf	E2F-4,interacting
R1026	T1204	T1200	themeOf	C/EBPβ,interacting
R1027	T1205	T1200	themeOf	cyclin T1,interacting
R1028	T1206	T1200	themeOf	CDK9,interacting
R1029	T1207	T1200	themeOf	p300,interacting
R1030	T1208	T1200	themeOf	CBP,interacting
R1031	T1209	T1200	themeOf	P/CAF,interacting
R1032	T1210	T1211	themeOf	Tat,binding
R1033	T1212	T1211	themeOf	Flk1/KDR receptor,binding
R1034	T1214	T1213	themeOf	Tat,expressed
R1035	T1215	T1219	causeOf	Tat,increased
R1036	T1215	T1216	causeOf	Tat,induced
R1037	T1215	T1222	causeOf	Tat,inhibiting
R1038	T1217	T1216	themeOf	degradation,induced
R1039	T1218	T1217	themeOf	IκB-α,degradation
R1040	T1220	T1221	themeOf	p65,transcriptional
R1041	T1221	T1219	themeOf	transcriptional,increased
R1042	T1222	T1219	causeOf	inhibiting,increased
R1043	T1223	T1224	causeOf	SIRT-1,mediated
R1044	T1224	T1222	themeOf	mediated,inhibiting
R1045	T1225	T1224	themeOf	deacetylation,mediated
R1046	T1226	T1225	themeOf	p65,deacetylation
R1047	T1227	T1229	causeOf	Tat,dependent
R1048	T1228	T1229	causeOf	Tat,dependent
R1049	T1230	T1229	themeOf	synthesis,dependent
R1050	T1231	T1230	themeOf	IκB-α,synthesis
R1051	T1232	T1237	themeOf	IκB-α,export
R1052	T1232	T1233	themeOf	IκB-α,binds
R1053	T1233	T1235	causeOf	binds,promotes
R1054	T1234	T1233	themeOf	Tat,binds
R1055	T1236	T1237	locationOf	nuclear,export
R1056	T1237	T1235	themeOf	export,promotes
R1057	T1238	T1242	themeOf	Tat,binding
R1058	T1238	T1239	themeOf	Tat,interaction
R1059	T1240	T1242	themeOf	IκB-α,binding
R1060	T1240	T1239	themeOf	IκB-α,interaction
R1061	T1241	T1239	themeOf	p65,interaction

bionlp-st-ge-2016-reference

Id	Subject	Object	Predicate	Lexical cue
T1250	289-292	Positive_regulation	denotes	for
T1251	289-292	Positive_regulation	denotes	for
T1252	289-292	Positive_regulation	denotes	for
T1253	289-292	Positive_regulation	denotes	for
T1254	289-292	Positive_regulation	denotes	for
T1255	289-292	Positive_regulation	denotes	for
T1256	289-292	Positive_regulation	denotes	for
T1257	289-292	Positive_regulation	denotes	for
T1258	289-292	Positive_regulation	denotes	for
T1259	289-292	Positive_regulation	denotes	for
T1260	289-292	Positive_regulation	denotes	for
T1261	289-292	Positive_regulation	denotes	for
T1262	289-292	Positive_regulation	denotes	for
T1263	289-292	Positive_regulation	denotes	for
T1264	289-292	Positive_regulation	denotes	for
T1265	289-292	Positive_regulation	denotes	for
T1266	289-292	Positive_regulation	denotes	for
T1267	289-292	Positive_regulation	denotes	for
T1268	289-292	Positive_regulation	denotes	for
T1269	289-292	Positive_regulation	denotes	for
T1270	289-292	Positive_regulation	denotes	for
T1271	289-292	Positive_regulation	denotes	for
T1272	289-292	Positive_regulation	denotes	for
T1273	289-292	Positive_regulation	denotes	for
T1274	289-292	Positive_regulation	denotes	for
T1275	289-292	Positive_regulation	denotes	for
T1276	289-292	Positive_regulation	denotes	for
T1277	289-292	Positive_regulation	denotes	for
T1278	289-292	Positive_regulation	denotes	for
T1279	289-292	Positive_regulation	denotes	for
T1280	289-292	Positive_regulation	denotes	for
T1281	289-292	Positive_regulation	denotes	for
T1282	289-292	Positive_regulation	denotes	for
T1283	289-292	Positive_regulation	denotes	for
T1284	289-292	Positive_regulation	denotes	for
T1285	289-292	Positive_regulation	denotes	for
T1286	289-292	Positive_regulation	denotes	for
T1287	289-292	Positive_regulation	denotes	for
T1288	289-292	Positive_regulation	denotes	for
T1289	289-292	Positive_regulation	denotes	for
T1290	289-292	Positive_regulation	denotes	for
T1291	289-292	Positive_regulation	denotes	for
T1292	289-292	Positive_regulation	denotes	for
T1293	289-292	Positive_regulation	denotes	for
T1294	289-292	Positive_regulation	denotes	for
T1295	289-292	Positive_regulation	denotes	for
T1296	289-292	Positive_regulation	denotes	for
T1297	289-292	Positive_regulation	denotes	for
T1298	289-292	Positive_regulation	denotes	for
T1299	289-292	Positive_regulation	denotes	for
T1300	309-321	Binding	denotes	dimerization
T1301	309-321	Binding	denotes	dimerization
T1302	309-321	Binding	denotes	dimerization
T1303	309-321	Binding	denotes	dimerization
T1304	309-321	Binding	denotes	dimerization
T1305	330-337	Binding	denotes	binding
T1306	330-337	Binding	denotes	binding
T1307	330-337	Binding	denotes	binding
T1308	330-337	Binding	denotes	binding
T1309	330-337	Binding	denotes	binding
T1310	507-510	Protein	denotes	p65
T1311	512-516	Protein	denotes	RelB
T1312	521-526	Protein	denotes	c-Rel
T1313	889-894	Protein	denotes	IκB-α
T1314	941-955	Phosphorylation	denotes	phosphorylated
T1315	941-955	Phosphorylation	denotes	phosphorylated
T1316	966-971	Entity	denotes	Ser32
T1317	976-981	Entity	denotes	Ser36
T1318	1004-1017	Ubiquitination	denotes	ubiquitylated
T1319	1004-1017	Ubiquitination	denotes	ubiquitylated
T1320	1021-1026	Entity	denotes	Lys21
T1321	1031-1036	Entity	denotes	Lys22
T1322	1043-1051	Protein_catabolism	denotes	degraded
T1323	1052-1054	Positive_regulation	denotes	by
T1324	1113-1128	Phosphorylation	denotes	phosphorylation
T1325	1113-1128	Phosphorylation	denotes	phosphorylation
T1326	1113-1128	Phosphorylation	denotes	phosphorylation
T1327	1132-1135	Protein	denotes	p65
T1328	1139-1145	Entity	denotes	Ser276
T1329	1146-1148	Positive_regulation	denotes	by
T1330	1157-1161	Protein	denotes	MSK1
T1331	1169-1175	Entity	denotes	Ser311
T1332	1176-1178	Positive_regulation	denotes	by
T1333	1179-1183	Protein	denotes	PKCζ
T1334	1192-1198	Entity	denotes	Ser536
T1335	1199-1201	Positive_regulation	denotes	by
T1336	1202-1206	Protein	denotes	IKKα
T1337	1216-1227	Acetylation	denotes	Acetylation
T1338	1216-1227	Acetylation	denotes	Acetylation
T1339	1231-1234	Protein	denotes	p65
T1340	1238-1244	Entity	denotes	Lys218
T1341	1249-1255	Entity	denotes	Lys221
T1342	1256-1265	Positive_regulation	denotes	increases
T1343	1256-1265	Positive_regulation	denotes	increases
T1359	1651-1662	Deacetylation	denotes	acetylation
T1360	1651-1662	Deacetylation	denotes	acetylation
T1361	1666-1669	Protein	denotes	p65
T1362	1673-1679	Entity	denotes	Lys122
T1363	1684-1690	Entity	denotes	Lys123
T1364	2450-2457	Binding	denotes	binding
T1365	2465-2470	Protein	denotes	gp120
T1366	2489-2492	Protein	denotes	CD4
T1367	2493-2500	Positive_regulation	denotes	induces
T1368	2523-2533	Positive_regulation	denotes	activation
T1369	2550-2562	Protein	denotes	procaspase 8
T1370	2622-2625	Protein	denotes	Tat
T1371	2634-2643	Binding	denotes	interacts
T1372	2719-2722	Protein	denotes	Tat
T1373	2723-2728	Binding	denotes	binds
T1374	2871-2894	Protein	denotes	tumor necrosis factor β
T1375	2896-2900	Protein	denotes	TNFβ
T1376	2911-2924	Protein	denotes	interleukin-6
T1377	2926-2930	Protein	denotes	IL-6
T1378	2940-2948	Positive_regulation	denotes	activate
T1379	2940-2948	Positive_regulation	denotes	activate
T1380	2954-2967	Transcription	denotes	transcription
T1381	2954-2967	Transcription	denotes	transcription
T1382	2977-2980	Protein	denotes	Tat
T1383	3039-3050	Binding	denotes	interacting
T1384	3039-3050	Binding	denotes	interacting
T1385	3039-3050	Binding	denotes	interacting
T1386	3039-3050	Binding	denotes	interacting
T1387	3039-3050	Binding	denotes	interacting
T1388	3039-3050	Binding	denotes	interacting
T1389	3039-3050	Binding	denotes	interacting
T1390	3039-3050	Binding	denotes	interacting
T1391	3039-3050	Binding	denotes	interacting
T1392	3099-3102	Protein	denotes	Sp1
T1393	3109-3114	Protein	denotes	TFIID
T1394	3121-3126	Protein	denotes	E2F-4
T1395	3133-3139	Protein	denotes	C/EBPβ
T1396	3146-3155	Protein	denotes	cyclin T1
T1397	3156-3160	Protein	denotes	CDK9
T1398	3204-3208	Protein	denotes	p300
T1399	3209-3212	Protein	denotes	CBP
T1400	3217-3222	Protein	denotes	P/CAF
T1401	3237-3245	Localization	denotes	released
T1402	3273-3276	Protein	denotes	Tat
T1403	3311-3318	Binding	denotes	binding
T1404	3362-3379	Protein	denotes	Flk1/KDR receptor
T1405	3498-3507	Gene_expression	denotes	expressed
T1406	3512-3515	Protein	denotes	Tat
T1407	3580-3583	Protein	denotes	Tat
T1408	3584-3591	Positive_regulation	denotes	induced
T1409	3625-3636	Protein_catabolism	denotes	degradation
T1410	3640-3645	Protein	denotes	IκB-α
T1411	3670-3673	Protein	denotes	p65
T1412	3702-3712	Negative_regulation	denotes	inhibiting
T1413	3717-3723	Protein	denotes	SIRT-1
T1414	3724-3732	Positive_regulation	denotes	mediated
T1415	3733-3746	Deacetylation	denotes	deacetylation
T1416	3750-3753	Protein	denotes	p65
T1417	3754-3760	Entity	denotes	Lys310
T1418	3797-3800	Protein	denotes	Tat
T1419	3884-3887	Protein	denotes	Tat
T1420	3971-3980	Gene_expression	denotes	synthesis
T1421	3984-3989	Protein	denotes	IκB-α
T1422	4024-4029	Protein	denotes	IκB-α
T1423	4030-4035	Binding	denotes	binds
T1424	4039-4042	Protein	denotes	Tat
T1425	4142-4145	Protein	denotes	Tat
T1426	4211-4222	Binding	denotes	interaction
T1427	4228-4233	Protein	denotes	IκB-α
T1428	4238-4241	Protein	denotes	p65
T1243	183-187	Protein	denotes	RelA
T1244	188-191	Protein	denotes	p65
T1245	193-198	Protein	denotes	c-Rel
T1246	200-204	Protein	denotes	RelB
T1247	206-209	Protein	denotes	p50
T1248	214-217	Protein	denotes	p52
T1249	263-282	Entity	denotes	Rel homology domain
T1344	1274-1281	Binding	denotes	binding
T1345	1286-1293	Negative_regulation	denotes	impairs
T1346	1286-1293	Negative_regulation	denotes	impairs
T1347	1298-1309	Binding	denotes	association
T1348	1315-1320	Protein	denotes	IκB-α
T1349	1326-1337	Acetylation	denotes	acetylation
T1350	1341-1347	Entity	denotes	Lys310
T1351	1361-1364	Protein	denotes	p65
T1352	1543-1548	Protein	denotes	IκB-α
T1353	1579-1582	Protein	denotes	A20
T1354	1592-1605	Deacetylation	denotes	Deacetylation
T1355	1592-1605	Deacetylation	denotes	Deacetylation
T1356	1609-1612	Protein	denotes	p65
T1357	1616-1637	Protein	denotes	histone deacetylase-3
T1358	1641-1646	Protein	denotes	SIRT1
R1062	T1243	T1302	themeOf	RelA,dimerization
R1065	T1245	T1301	themeOf	c-Rel,dimerization
R1083	T1249	T1265	causeOf	Rel homology domain,for
R1084	T1249	T1264	causeOf	Rel homology domain,for
R1085	T1249	T1263	causeOf	Rel homology domain,for
R1086	T1249	T1262	causeOf	Rel homology domain,for
R1087	T1249	T1257	causeOf	Rel homology domain,for
R1088	T1249	T1243	partOf	Rel homology domain,RelA
R1089	T1249	T1256	causeOf	Rel homology domain,for
R1090	T1249	T1245	partOf	Rel homology domain,c-Rel
R1091	T1249	T1255	causeOf	Rel homology domain,for
R1092	T1249	T1246	partOf	Rel homology domain,RelB
R1093	T1249	T1253	causeOf	Rel homology domain,for
R1094	T1249	T1247	partOf	Rel homology domain,p50
R1095	T1249	T1252	causeOf	Rel homology domain,for
R1096	T1249	T1248	partOf	Rel homology domain,p52
R1097	T1249	T1251	causeOf	Rel homology domain,for
R1098	T1249	T1271	causeOf	Rel homology domain,for
R1110	T1249	T1284	causeOf	Rel homology domain,for
R1111	T1249	T1298	causeOf	Rel homology domain,for
R1112	T1249	T1297	causeOf	Rel homology domain,for
R1113	T1249	T1295	causeOf	Rel homology domain,for
R1114	T1249	T1294	causeOf	Rel homology domain,for
R1115	T1249	T1293	causeOf	Rel homology domain,for
R1116	T1249	T1292	causeOf	Rel homology domain,for
R1117	T1249	T1291	causeOf	Rel homology domain,for
R1118	T1249	T1289	causeOf	Rel homology domain,for
R1119	T1249	T1288	causeOf	Rel homology domain,for
R1120	T1249	T1287	causeOf	Rel homology domain,for
R1121	T1249	T1286	causeOf	Rel homology domain,for
R1122	T1249	T1285	causeOf	Rel homology domain,for
R1123	T1249	T1283	causeOf	Rel homology domain,for
R1124	T1249	T1282	causeOf	Rel homology domain,for
R1125	T1249	T1281	causeOf	Rel homology domain,for
R1126	T1249	T1280	causeOf	Rel homology domain,for
R1127	T1249	T1279	causeOf	Rel homology domain,for
R1128	T1300	T1297	themeOf	dimerization,for
R1129	T1300	T1295	themeOf	dimerization,for
R1130	T1300	T1294	themeOf	dimerization,for
R1131	T1300	T1293	themeOf	dimerization,for
R1132	T1300	T1292	themeOf	dimerization,for
R1133	T1301	T1251	themeOf	dimerization,for
R1134	T1301	T1271	themeOf	dimerization,for
R1135	T1301	T1290	themeOf	dimerization,for
R1136	T1301	T1299	themeOf	dimerization,for
R1137	T1301	T1254	themeOf	dimerization,for
R1138	T1302	T1257	themeOf	dimerization,for
R1139	T1302	T1256	themeOf	dimerization,for
R1140	T1302	T1255	themeOf	dimerization,for
R1141	T1302	T1253	themeOf	dimerization,for
R1142	T1302	T1252	themeOf	dimerization,for
R1143	T1303	T1272	themeOf	dimerization,for
R1144	T1303	T1278	themeOf	dimerization,for
R1145	T1303	T1296	themeOf	dimerization,for
R1146	T1303	T1284	themeOf	dimerization,for
R1147	T1303	T1298	themeOf	dimerization,for
R1148	T1304	T1258	themeOf	dimerization,for
R1149	T1304	T1259	themeOf	dimerization,for
R1150	T1304	T1260	themeOf	dimerization,for
R1151	T1304	T1261	themeOf	dimerization,for
R1152	T1304	T1266	themeOf	dimerization,for
R1153	T1305	T1285	themeOf	binding,for
R1154	T1305	T1283	themeOf	binding,for
R1155	T1305	T1282	themeOf	binding,for
R1156	T1305	T1281	themeOf	binding,for
R1157	T1305	T1280	themeOf	binding,for
R1158	T1306	T1277	themeOf	binding,for
R1159	T1306	T1276	themeOf	binding,for
R1160	T1306	T1275	themeOf	binding,for
R1161	T1306	T1274	themeOf	binding,for
R1162	T1306	T1279	themeOf	binding,for
R1163	T1307	T1291	themeOf	binding,for
R1164	T1307	T1289	themeOf	binding,for
R1165	T1307	T1288	themeOf	binding,for
R1166	T1307	T1287	themeOf	binding,for
R1167	T1307	T1286	themeOf	binding,for
R1168	T1308	T1273	themeOf	binding,for
R1169	T1308	T1250	themeOf	binding,for
R1170	T1308	T1270	themeOf	binding,for
R1171	T1308	T1269	themeOf	binding,for
R1172	T1308	T1268	themeOf	binding,for
R1173	T1309	T1267	themeOf	binding,for
R1174	T1309	T1265	themeOf	binding,for
R1175	T1309	T1264	themeOf	binding,for
R1176	T1309	T1263	themeOf	binding,for
R1177	T1309	T1262	themeOf	binding,for
R1178	T1313	T1322	themeOf	IκB-α,degraded
R1179	T1316	T1315	themeOf	Ser32,phosphorylated
R1180	T1316	T1313	partOf	Ser32,IκB-α
R1181	T1317	T1314	themeOf	Ser36,phosphorylated
R1182	T1317	T1313	partOf	Ser36,IκB-α
R1183	T1320	T1318	themeOf	Lys21,ubiquitylated
R1184	T1320	T1313	partOf	Lys21,IκB-α
R1185	T1321	T1319	themeOf	Lys22,ubiquitylated
R1186	T1321	T1313	partOf	Lys22,IκB-α
R1187	T1322	T1323	themeOf	degraded,by
R1188	T1324	T1329	themeOf	phosphorylation,by
R1189	T1324	T1332	themeOf	phosphorylation,by
R1190	T1324	T1335	themeOf	phosphorylation,by
R1191	T1328	T1324	themeOf	Ser276,phosphorylation
R1192	T1328	T1327	partOf	Ser276,p65
R1193	T1330	T1329	causeOf	MSK1,by
R1194	T1331	T1326	themeOf	Ser311,phosphorylation
R1195	T1331	T1327	partOf	Ser311,p65
R1196	T1333	T1332	causeOf	PKCζ,by
R1197	T1334	T1325	themeOf	Ser536,phosphorylation
R1198	T1334	T1327	partOf	Ser536,p65
R1199	T1336	T1335	causeOf	IKKα,by
R1200	T1337	T1343	causeOf	Acetylation,increases
R1201	T1337	T1345	causeOf	Acetylation,impairs
R1202	T1338	T1342	causeOf	Acetylation,increases
R1203	T1338	T1346	causeOf	Acetylation,impairs
R1204	T1339	T1344	themeOf	p65,binding
R1205	T1339	T1347	themeOf	p65,association
R1206	T1340	T1337	themeOf	Lys218,Acetylation
R1207	T1340	T1339	partOf	Lys218,p65
R1208	T1341	T1338	themeOf	Lys221,Acetylation
R1209	T1341	T1339	partOf	Lys221,p65
R1210	T1344	T1343	themeOf	binding,increases
R1211	T1344	T1342	themeOf	binding,increases
R1212	T1347	T1345	themeOf	association,impairs
R1213	T1347	T1346	themeOf	association,impairs
R1214	T1348	T1347	themeOf	IκB-α,association
R1215	T1350	T1349	themeOf	Lys310,acetylation
R1216	T1350	T1339	partOf	Lys310,p65
R1217	T1356	T1355	themeOf	p65,Deacetylation
R1218	T1356	T1354	themeOf	p65,Deacetylation
R1219	T1357	T1355	causeOf	histone deacetylase-3,Deacetylation
R1220	T1358	T1354	causeOf	SIRT1,Deacetylation
R1221	T1362	T1359	themeOf	Lys122,acetylation
R1222	T1362	T1361	partOf	Lys122,p65
R1223	T1363	T1360	themeOf	Lys123,acetylation
R1224	T1363	T1361	partOf	Lys123,p65
R1225	T1364	T1367	causeOf	binding,induces
R1226	T1365	T1364	themeOf	gp120,binding
R1227	T1366	T1364	themeOf	CD4,binding
R1228	T1368	T1367	themeOf	activation,induces
R1229	T1369	T1368	themeOf	procaspase 8,activation
R1230	T1370	T1371	themeOf	Tat,interacts
R1231	T1372	T1373	themeOf	Tat,binds
R1232	T1373	T1379	causeOf	binds,activate
R1233	T1373	T1378	causeOf	binds,activate
R1234	T1374	T1380	themeOf	tumor necrosis factor β,transcription
R1235	T1375	T1374	equivalentTo	TNFβ,tumor necrosis factor β
R1236	T1376	T1381	themeOf	interleukin-6,transcription
R1237	T1377	T1376	equivalentTo	IL-6,interleukin-6
R1238	T1380	T1379	themeOf	transcription,activate
R1239	T1381	T1378	themeOf	transcription,activate
R1240	T1382	T1384	themeOf	Tat,interacting
R1241	T1382	T1386	themeOf	Tat,interacting
R1242	T1382	T1385	themeOf	Tat,interacting
R1243	T1382	T1383	themeOf	Tat,interacting
R1244	T1382	T1387	themeOf	Tat,interacting
R1245	T1382	T1388	themeOf	Tat,interacting
R1246	T1382	T1389	themeOf	Tat,interacting
R1247	T1382	T1391	themeOf	Tat,interacting
R1248	T1382	T1390	themeOf	Tat,interacting
R1249	T1392	T1384	themeOf	Sp1,interacting
R1250	T1393	T1386	themeOf	TFIID,interacting
R1251	T1394	T1385	themeOf	E2F-4,interacting
R1252	T1395	T1383	themeOf	C/EBPβ,interacting
R1253	T1396	T1387	themeOf	cyclin T1,interacting
R1254	T1397	T1388	themeOf	CDK9,interacting
R1255	T1398	T1389	themeOf	p300,interacting
R1256	T1399	T1391	themeOf	CBP,interacting
R1257	T1400	T1390	themeOf	P/CAF,interacting
R1258	T1402	T1401	themeOf	Tat,released
R1259	T1402	T1403	themeOf	Tat,binding
R1260	T1406	T1405	themeOf	Tat,expressed
R1261	T1407	T1408	causeOf	Tat,induced
R1262	T1407	T1412	causeOf	Tat,inhibiting
R1263	T1409	T1408	themeOf	degradation,induced
R1264	T1410	T1409	themeOf	IκB-α,degradation
R1265	T1413	T1414	causeOf	SIRT-1,mediated
R1266	T1414	T1412	themeOf	mediated,inhibiting
R1267	T1415	T1414	themeOf	deacetylation,mediated
R1268	T1417	T1415	themeOf	Lys310,deacetylation
R1269	T1417	T1416	partOf	Lys310,p65
R1270	T1421	T1420	themeOf	IκB-α,synthesis
R1271	T1422	T1423	themeOf	IκB-α,binds
R1272	T1424	T1423	themeOf	Tat,binds
R1273	T1425	T1426	themeOf	Tat,interaction
R1274	T1427	T1426	themeOf	IκB-α,interaction
R1064	T1244	T1243	equivalentTo	p65,RelA
R1069	T1247	T1308	themeOf	p50,binding
R1071	T1248	T1309	themeOf	p52,binding
R1073	T1249	T1277	causeOf	Rel homology domain,for
R1074	T1249	T1276	causeOf	Rel homology domain,for
R1075	T1249	T1275	causeOf	Rel homology domain,for
R1076	T1249	T1274	causeOf	Rel homology domain,for
R1077	T1249	T1273	causeOf	Rel homology domain,for
R1078	T1249	T1250	causeOf	Rel homology domain,for
R1079	T1249	T1270	causeOf	Rel homology domain,for
R1080	T1249	T1269	causeOf	Rel homology domain,for
R1081	T1249	T1268	causeOf	Rel homology domain,for
R1082	T1249	T1267	causeOf	Rel homology domain,for
R1063	T1243	T1307	themeOf	RelA,binding
R1066	T1245	T1305	themeOf	c-Rel,binding
R1067	T1246	T1304	themeOf	RelB,dimerization
R1068	T1246	T1306	themeOf	RelB,binding
R1070	T1247	T1303	themeOf	p50,dimerization
R1072	T1248	T1300	themeOf	p52,dimerization
R1099	T1249	T1290	causeOf	Rel homology domain,for
R1100	T1249	T1299	causeOf	Rel homology domain,for
R1101	T1249	T1254	causeOf	Rel homology domain,for
R1102	T1249	T1258	causeOf	Rel homology domain,for
R1103	T1249	T1259	causeOf	Rel homology domain,for
R1104	T1249	T1260	causeOf	Rel homology domain,for
R1105	T1249	T1261	causeOf	Rel homology domain,for
R1106	T1249	T1266	causeOf	Rel homology domain,for
R1107	T1249	T1272	causeOf	Rel homology domain,for
R1108	T1249	T1278	causeOf	Rel homology domain,for
R1109	T1249	T1296	causeOf	Rel homology domain,for

bionlp-st-ge-2016-uniprot

Id	Subject	Object	Predicate	Lexical cue
T2244	183-187	Q04206-3	denotes	RelA
T2245	183-187	Q04206	denotes	RelA
T2246	188-191	Q04206	denotes	p65
T2247	188-191	P21579	denotes	p65
T2248	193-198	Q04864	denotes	c-Rel
T2249	195-198	Q04864	denotes	Rel
T2250	200-204	Q01201	denotes	RelB
T2251	206-209	P19838	denotes	p50
T2252	214-217	Q00653	denotes	p52
T2253	263-266	Q04864	denotes	Rel
T2254	507-510	Q04206	denotes	p65
T2255	507-510	P21579	denotes	p65
T2256	512-516	Q01201	denotes	RelB
T2257	521-526	Q04864	denotes	c-Rel
T2258	523-526	Q04864	denotes	Rel
T2259	694-704	O15111	denotes	IκB kinase
T2260	694-704	Q60680-2	denotes	IκB kinase
T2261	1132-1135	P21579	denotes	p65
T2262	1132-1135	Q04206	denotes	p65
T2263	1157-1161	O75582	denotes	MSK1
T2264	1231-1234	P21579	denotes	p65
T2265	1231-1234	Q04206	denotes	p65
T2266	1361-1364	Q04206	denotes	p65
T2267	1361-1364	P21579	denotes	p65
T2268	1579-1582	P21580	denotes	A20
T2269	1609-1612	P21579	denotes	p65
T2270	1609-1612	Q04206	denotes	p65
T2271	1641-1646	Q96EB6	denotes	SIRT1
T2272	1666-1669	P21579	denotes	p65
T2273	1666-1669	Q04206	denotes	p65
T2274	2489-2492	P01730	denotes	CD4
T2275	2622-2625	P04610	denotes	Tat
T2276	2622-2625	P04608	denotes	Tat
T2277	2622-2625	P04605	denotes	Tat
T2278	2622-2625	Q8UMQ1	denotes	Tat
T2279	2719-2722	P04608	denotes	Tat
T2280	2719-2722	P04610	denotes	Tat
T2281	2719-2722	P04605	denotes	Tat
T2282	2719-2722	Q8UMQ1	denotes	Tat
T2283	2871-2892	P01375	denotes	tumor necrosis factor
T2284	2911-2924	P05231	denotes	interleukin-6
T2285	2926-2930	P05231	denotes	IL-6
T2286	2977-2980	P04610	denotes	Tat
T2287	2977-2980	P04608	denotes	Tat
T2288	2977-2980	P04605	denotes	Tat
T2289	2977-2980	Q8UMQ1	denotes	Tat
T2290	3099-3102	P08047	denotes	Sp1
T2291	3177-3208	Q09472	denotes	histone acetyltransferases p300
T2292	3204-3208	Q09472	denotes	p300
T2293	3209-3212	Q92793	denotes	CBP
T2294	3219-3222	Q13111	denotes	CAF
T2295	3273-3276	Q8UMQ1	denotes	Tat
T2296	3273-3276	P04605	denotes	Tat
T2297	3273-3276	P04608	denotes	Tat
T2298	3273-3276	P04610	denotes	Tat
T2299	3512-3515	P04610	denotes	Tat
T2300	3512-3515	Q8UMQ1	denotes	Tat
T2301	3512-3515	P04608	denotes	Tat
T2302	3512-3515	P04605	denotes	Tat
T2303	3580-3583	P04605	denotes	Tat
T2304	3580-3583	P04608	denotes	Tat
T2305	3580-3583	P04610	denotes	Tat
T2306	3580-3583	Q8UMQ1	denotes	Tat
T2307	3670-3673	Q04206	denotes	p65
T2308	3670-3673	P21579	denotes	p65
T2309	3750-3753	Q04206	denotes	p65
T2310	3750-3753	P21579	denotes	p65
T2311	3797-3800	Q8UMQ1	denotes	Tat
T2312	3797-3800	P04605	denotes	Tat
T2313	3797-3800	P04610	denotes	Tat
T2314	3797-3800	P04608	denotes	Tat
T2315	3884-3887	P04605	denotes	Tat
T2316	3884-3887	Q8UMQ1	denotes	Tat
T2317	3884-3887	P04608	denotes	Tat
T2318	3884-3887	P04610	denotes	Tat
T2319	4039-4042	P04605	denotes	Tat
T2320	4039-4042	Q8UMQ1	denotes	Tat
T2321	4039-4042	P04610	denotes	Tat
T2322	4039-4042	P04608	denotes	Tat
T2323	4142-4145	Q8UMQ1	denotes	Tat
T2324	4142-4145	P04605	denotes	Tat
T2325	4142-4145	P04610	denotes	Tat
T2326	4142-4145	P04608	denotes	Tat
T2327	4238-4241	Q04206	denotes	p65
T2328	4238-4241	P21579	denotes	p65

PMC:3333881 / 1360-5823 JSONTXT

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PMC:3333881 / 1360-5823 JSON TXT