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2_test

Id Subject Object Predicate Lexical cue
22187158-18927578-77584393 1513-1514 18927578 denotes 1
22187158-19302050-77584394 1888-1889 19302050 denotes 2
22187158-12360211-77584395 1990-1991 12360211 denotes 3
22187158-1829648-77584396 2294-2295 1829648 denotes 4
22187158-7878466-77584397 2343-2344 7878466 denotes 5
22187158-7479976-77584398 2435-2436 7479976 denotes 6
22187158-9660950-77584399 2523-2524 9660950 denotes 7
22187158-12628924-77584400 2525-2526 12628924 denotes 8
22187158-12881425-77584401 2545-2546 12881425 denotes 9
22187158-10521409-77584402 2568-2570 10521409 denotes 10
22187158-14963024-77584403 2571-2573 14963024 denotes 11
22187158-11533489-77584404 2751-2753 11533489 denotes 12
22187158-12456660-77584405 2754-2756 12456660 denotes 13
22187158-8096091-77584406 2947-2949 8096091 denotes 20
22187158-8319912-77584406 2947-2949 8319912 denotes 20
22187158-12424381-77584406 2947-2949 12424381 denotes 20
22187158-15499023-77584406 2947-2949 15499023 denotes 20
22187158-15258597-77584406 2947-2949 15258597 denotes 20
22187158-18676814-77584406 2947-2949 18676814 denotes 20
22187158-11533489-77584407 3085-3087 11533489 denotes 12
22187158-12419806-77584408 3088-3090 12419806 denotes 21
22187158-15152190-77584409 3091-3093 15152190 denotes 22
22187158-7853483-77584410 3359-3361 7853483 denotes 25
22187158-11160127-77584410 3359-3361 11160127 denotes 25
22187158-8764027-77584410 3359-3361 8764027 denotes 25
22187158-18947296-77584411 3444-3446 18947296 denotes 26
22187158-19840555-77584412 3447-3449 19840555 denotes 27
22187158-11160730-77584413 3663-3665 11160730 denotes 28
22187158-18806803-77584414 3666-3668 18806803 denotes 29
22187158-11959143-77584415 3902-3904 11959143 denotes 30
22187158-19287489-77584416 3924-3926 19287489 denotes 31
22187158-2478293-77584417 4226-4228 2478293 denotes 32
22187158-8139045-77584418 4263-4265 8139045 denotes 33
22187158-9169458-77584419 4293-4295 9169458 denotes 34
22187158-7690421-77584420 4464-4466 7690421 denotes 35
22187158-8121496-77584421 4476-4478 8121496 denotes 36
22187158-12055184-77584422 4488-4490 12055184 denotes 37
22187158-15710476-77584423 4501-4503 15710476 denotes 38
22187158-7853496-77584424 4522-4524 7853496 denotes 39
22187158-9491887-77584425 4525-4527 9491887 denotes 40
22187158-9811832-77584426 4587-4589 9811832 denotes 43
22187158-9733868-77584426 4587-4589 9733868 denotes 43
22187158-9733796-77584426 4587-4589 9733796 denotes 43
22187158-10397733-77584427 4717-4719 10397733 denotes 44
22187158-8946838-77584428 4741-4743 8946838 denotes 45
22187158-9789057-77584429 4770-4772 9789057 denotes 46
22187158-8113688-77584430 4882-4884 8113688 denotes 47
22187158-8676466-77584431 5007-5009 8676466 denotes 48
22187158-18329615-77584432 5122-5124 18329615 denotes 49
22187158-8096091-77584433 5351-5353 8096091 denotes 15
22187158-12424381-77584434 5354-5356 12424381 denotes 17
22187158-17942396-77584435 5464-5466 17942396 denotes 50
22187158-21664225-77584436 5467-5469 21664225 denotes 51
22187158-17942396-77584437 6077-6079 17942396 denotes 50
22187158-14532125-77584438 6670-6672 14532125 denotes 52
22187158-19782003-77584439 6887-6889 19782003 denotes 53
22187158-17942396-77584440 9315-9317 17942396 denotes 50
22187158-8537390-77584441 9467-9469 8537390 denotes 54
22187158-15613239-77584442 10882-10884 15613239 denotes 55
22187158-17942396-77584443 11133-11135 17942396 denotes 50
22187158-17942396-77584444 11366-11368 17942396 denotes 50
22187158-12424381-77584445 18935-18937 12424381 denotes 17
22187158-15499023-77584446 18938-18940 15499023 denotes 18
22187158-17942396-77584447 21882-21884 17942396 denotes 50
22187158-21664225-77584448 21885-21887 21664225 denotes 51
22187158-17942396-77584449 23094-23096 17942396 denotes 50
22187158-21664225-77584450 23097-23099 21664225 denotes 51
22187158-15203102-77584451 33111-33113 15203102 denotes 56
22187158-10751368-77584452 33229-33231 10751368 denotes 57
22187158-19596987-77584453 33232-33234 19596987 denotes 58
22187158-8570619-77584454 33297-33299 8570619 denotes 59
22187158-11602715-77584455 33300-33302 11602715 denotes 60
22187158-10751368-77584456 33321-33323 10751368 denotes 57
22187158-10964543-77584457 33324-33326 10964543 denotes 61
22187158-20403075-77584458 33327-33329 20403075 denotes 62
22187158-18329615-77584459 39726-39728 18329615 denotes 49
22187158-1583734-77584460 39729-39731 1583734 denotes 63
22187158-10544088-77584461 39732-39734 10544088 denotes 64
22187158-17942396-77584462 39789-39791 17942396 denotes 50
22187158-21664225-77584463 39792-39794 21664225 denotes 51
22187158-11959143-77584464 40179-40181 11959143 denotes 30
22187158-19287489-77584465 40182-40184 19287489 denotes 31
22187158-17942396-77584466 41753-41755 17942396 denotes 50
22187158-21664225-77584467 41756-41758 21664225 denotes 51
22187158-15536134-77584468 43408-43410 15536134 denotes 65
22187158-15536134-77584469 43838-43840 15536134 denotes 65
22187158-2257304-77584470 44787-44789 2257304 denotes 66
22187158-1930778-77584471 44790-44792 1930778 denotes 67
22187158-2114424-77584472 44802-44804 2114424 denotes 68
22187158-10751368-77584473 44822-44824 10751368 denotes 62
22187158-19596987-77584473 44822-44824 19596987 denotes 62
22187158-8570619-77584473 44822-44824 8570619 denotes 62
22187158-11602715-77584473 44822-44824 11602715 denotes 62
22187158-10964543-77584473 44822-44824 10964543 denotes 62
22187158-20403075-77584473 44822-44824 20403075 denotes 62
22187158-8634452-77584474 44828-44830 8634452 denotes 71
22187158-8623908-77584474 44828-44830 8623908 denotes 71
22187158-11287580-77584474 44828-44830 11287580 denotes 71
22187158-8139045-77584475 45015-45017 8139045 denotes 33
22187158-12055184-77584476 45018-45020 12055184 denotes 37
22187158-8113688-77584477 45021-45023 8113688 denotes 47
22187158-1727476-77584478 45460-45462 1727476 denotes 72
22187158-16280076-77584479 45463-45465 16280076 denotes 73
22187158-18947296-77584480 45569-45571 18947296 denotes 26
22187158-10602409-77584481 45605-45607 10602409 denotes 74
22187158-16697675-77584482 45608-45610 16697675 denotes 75
22187158-19149660-77584483 45962-45964 19149660 denotes 76
22187158-19426715-77584484 45965-45967 19426715 denotes 77

pmc-enju-pas

Id Subject Object Predicate Lexical cue
T142 0-5 JJ denotes Human
T143 6-22 NN denotes immunodeficiency
T144 23-30 NN denotes virus-1
T145 31-34 NN denotes Tat
T146 35-44 VB denotes activates
T147 45-50 NN denotes NF-κB
T148 51-54 IN denotes via
T149 55-63 JJ denotes physical
T150 64-75 NN denotes interaction
T151 76-80 IN denotes with
T152 81-86 NN denotes IκB-α
T153 87-90 CC denotes and
T154 91-94 NN denotes p65
T155 106-113 JJ denotes Nuclear
T156 114-120 NN denotes factor
T157 121-122 -LRB- denotes (
T158 122-124 NN denotes NF
T159 124-125 -RRB- denotes )
T160 125-128 NN denotes -κB
T161 129-131 VB denotes is
T162 132-133 DT denotes a
T163 134-140 NN denotes master
T164 141-150 NN denotes regulator
T165 151-153 IN denotes of
T166 154-170 JJ denotes pro-inflammatory
T167 171-176 NN denotes genes
T168 177-180 CC denotes and
T169 181-183 VB denotes is
T170 184-195 VB denotes upregulated
T171 196-198 IN denotes in
T172 199-204 JJ denotes human
T173 205-221 NN denotes immunodeficiency
T174 222-227 NN denotes virus
T175 228-229 CD denotes 1
T176 230-231 -LRB- denotes (
T177 231-236 NN denotes HIV-1
T178 236-237 -RRB- denotes )
T179 238-247 NN denotes infection
T180 249-259 NN denotes Mechanisms
T181 260-270 VB denotes underlying
T182 271-274 DT denotes the
T183 275-280 NN denotes NF-κB
T184 281-293 NN denotes deregulation
T185 294-296 IN denotes by
T186 297-302 NN denotes HIV-1
T187 303-306 VB denotes are
T188 307-315 JJ denotes relevant
T189 316-319 IN denotes for
T190 320-326 JJ denotes immune
T191 327-338 NN denotes dysfunction
T192 339-341 IN denotes in
T193 342-346 NN denotes AIDS
T194 348-350 PRP denotes We
T195 351-357 VB denotes report
T196 358-362 IN denotes that
T197 363-365 IN denotes in
T198 366-372 JJ denotes single
T199 373-378 JJ denotes round
T200 379-384 NN denotes HIV-1
T201 385-394 NN denotes infection
T202 394-395 -COMMA- denotes ,
T203 396-398 CC denotes or
T204 399-411 JJ denotes single-pulse
T205 412-415 NN denotes PMA
T206 416-427 NN denotes stimulation
T207 427-428 -COMMA- denotes ,
T208 429-432 DT denotes the
T209 433-438 NN denotes HIV-1
T210 439-442 NN denotes Tat
T211 443-457 NN denotes transactivator
T212 458-467 VB denotes activated
T213 468-473 NN denotes NF-κB
T214 474-476 IN denotes by
T215 477-486 VB denotes hijacking
T216 487-490 DT denotes the
T217 491-500 NN denotes inhibitor
T218 501-506 NN denotes IκB-α
T219 507-510 CC denotes and
T220 511-513 IN denotes by
T221 514-524 VB denotes preventing
T222 525-528 DT denotes the
T223 529-538 NN denotes repressor
T224 539-546 NN denotes binding
T225 547-549 TO denotes to
T226 550-553 DT denotes the
T227 554-559 NN denotes NF-κB
T228 560-567 NN denotes complex
T229 569-577 RB denotes Moreover
T230 577-578 -COMMA- denotes ,
T231 579-582 NN denotes Tat
T232 583-593 VB denotes associated
T233 594-598 IN denotes with
T234 599-602 DT denotes the
T235 603-606 NN denotes p65
T236 607-614 NN denotes subunit
T237 615-617 IN denotes of
T238 618-623 NN denotes NF-κB
T239 624-627 CC denotes and
T240 628-637 VB denotes increased
T241 638-641 DT denotes the
T242 642-645 NN denotes p65
T243 646-657 JJ denotes DNA-binding
T244 658-666 NN denotes affinity
T245 667-670 CC denotes and
T246 671-686 JJ denotes transcriptional
T247 687-695 NN denotes activity
T248 697-700 DT denotes The
T249 701-710 NN denotes arginine-
T250 711-714 CC denotes and
T251 715-728 JJ denotes cysteine-rich
T252 729-736 NN denotes domains
T253 737-739 IN denotes of
T254 740-743 NN denotes Tat
T255 744-748 VB denotes were
T256 749-757 VB denotes required
T257 758-761 IN denotes for
T258 762-767 NN denotes IκB-α
T259 768-771 CC denotes and
T260 772-775 NN denotes p65
T261 776-787 NN denotes association
T262 787-788 -COMMA- denotes ,
T263 789-801 RB denotes respectively
T264 801-802 -COMMA- denotes ,
T265 803-806 CC denotes and
T266 807-810 IN denotes for
T267 811-821 VB denotes sustaining
T268 822-825 DT denotes the
T269 826-831 NN denotes NF-κB
T270 832-840 NN denotes activity
T271 842-847 IN denotes Among
T272 848-850 DT denotes an
T273 851-856 NN denotes array
T274 857-859 IN denotes of
T275 860-876 JJ denotes NF-κB-responsive
T276 877-882 NN denotes genes
T277 882-883 -COMMA- denotes ,
T278 884-887 NN denotes Tat
T279 888-894 RB denotes mostly
T280 895-904 VB denotes activated
T281 905-908 DT denotes the
T282 909-915 NN denotes MIP-1α
T283 916-926 NN denotes expression
T284 927-929 IN denotes in
T285 930-931 DT denotes a
T286 932-945 JJ denotes p65-dependent
T287 946-952 NN denotes manner
T288 952-953 -COMMA- denotes ,
T289 954-957 CC denotes and
T290 958-963 VB denotes bound
T291 964-966 TO denotes to
T292 967-970 DT denotes the
T293 971-977 NN denotes MIP-1α
T294 978-983 NN denotes NF-κB
T295 984-992 NN denotes enhancer
T296 993-997 RB denotes thus
T297 998-1007 VB denotes promoting
T298 1008-1011 DT denotes the
T299 1012-1023 NN denotes recruitment
T300 1024-1026 IN denotes of
T301 1027-1030 NN denotes p65
T302 1031-1035 IN denotes with
T303 1036-1048 NN denotes displacement
T304 1049-1051 IN denotes of
T305 1052-1057 NN denotes IκB-α
T306 1057-1058 -COLON- denotes ;
T307 1059-1066 JJ denotes similar
T308 1067-1075 NN denotes findings
T309 1076-1080 VB denotes were
T310 1081-1089 VB denotes obtained
T311 1090-1093 IN denotes for
T312 1094-1097 DT denotes the
T313 1098-1114 JJ denotes NF-κB-responsive
T314 1115-1120 NN denotes genes
T315 1121-1125 NN denotes CSF3
T316 1125-1126 -COMMA- denotes ,
T317 1127-1130 NN denotes LTA
T318 1130-1131 -COMMA- denotes ,
T319 1132-1138 NN denotes NFKBIA
T320 1139-1142 CC denotes and
T321 1143-1147 NN denotes TLR2
T322 1149-1152 PRP-DOLLAR- denotes Our
T323 1153-1160 NN denotes results
T324 1161-1168 VB denotes support
T325 1169-1170 DT denotes a
T326 1171-1176 JJ denotes novel
T327 1177-1186 NN denotes mechanism
T328 1187-1189 IN denotes of
T329 1190-1195 NN denotes NF-κB
T330 1196-1206 NN denotes activation
T331 1207-1210 IN denotes via
T332 1211-1219 JJ denotes physical
T333 1220-1231 NN denotes interaction
T334 1232-1234 IN denotes of
T335 1235-1238 NN denotes Tat
T336 1239-1243 IN denotes with
T337 1244-1249 NN denotes IκB-α
T338 1250-1253 CC denotes and
T339 1254-1257 NN denotes p65
T340 1257-1258 -COMMA- denotes ,
T341 1259-1262 CC denotes and
T342 1263-1266 MD denotes may
T343 1267-1277 VB denotes contribute
T344 1278-1280 TO denotes to
T345 1281-1288 JJ denotes further
T346 1289-1297 NN denotes insights
T347 1298-1302 IN denotes into
T348 1303-1306 DT denotes the
T349 1307-1319 NN denotes deregulation
T350 1320-1322 IN denotes of
T351 1323-1326 DT denotes the
T352 1327-1339 JJ denotes inflammatory
T353 1340-1348 NN denotes response
T354 1349-1351 IN denotes by
T355 1352-1357 NN denotes HIV-1
T1454 1373-1380 JJ denotes Nuclear
T1455 1381-1387 NN denotes factor
T1456 1388-1389 -LRB- denotes (
T1457 1389-1391 NN denotes NF
T1458 1391-1392 -RRB- denotes )
T1459 1392-1395 NN denotes -κB
T1460 1396-1409 NN denotes transcription
T1461 1410-1417 NN denotes factors
T1462 1418-1426 VB denotes regulate
T1463 1427-1430 DT denotes the
T1464 1431-1444 NN denotes transcription
T1465 1445-1447 IN denotes of
T1466 1448-1453 NN denotes genes
T1467 1454-1458 WDT denotes that
T1468 1459-1462 VB denotes are
T1469 1463-1471 VB denotes involved
T1470 1472-1474 IN denotes in
T1471 1475-1478 DT denotes the
T1472 1479-1485 JJ denotes immune
T1473 1486-1489 CC denotes and
T1474 1490-1502 JJ denotes inflammatory
T1475 1503-1511 NN denotes response
T1476 1512-1513 -LRB- denotes (
T1477 1513-1514 CD denotes 1
T1478 1514-1515 -RRB- denotes )
T1479 1517-1520 DT denotes The
T1480 1521-1526 NN denotes NF-κB
T1481 1527-1533 NN denotes family
T1482 1534-1542 VB denotes includes
T1483 1543-1551 NN denotes RelA/p65
T1484 1551-1552 -COMMA- denotes ,
T1485 1553-1558 NN denotes c-Rel
T1486 1558-1559 -COMMA- denotes ,
T1487 1560-1564 NN denotes RelB
T1488 1564-1565 -COMMA- denotes ,
T1489 1566-1569 NN denotes p50
T1490 1570-1573 CC denotes and
T1491 1574-1577 NN denotes p52
T1492 1578-1582 WDT denotes that
T1493 1583-1588 VB denotes share
T1494 1589-1590 DT denotes a
T1495 1591-1597 RB denotes highly
T1496 1598-1607 VB denotes conserved
T1497 1608-1617 JJ denotes 300-amino
T1498 1618-1622 NN denotes acid
T1499 1623-1626 NN denotes Rel
T1500 1627-1635 NN denotes homology
T1501 1636-1642 NN denotes domain
T1502 1643-1644 -LRB- denotes (
T1503 1644-1647 NN denotes RHD
T1504 1647-1648 -RRB- denotes )
T1505 1649-1652 IN denotes for
T1506 1653-1658 JJ denotes homo-
T1507 1659-1661 CC denotes or
T1508 1662-1681 NN denotes hetero-dimerization
T1509 1682-1685 CC denotes and
T1510 1686-1697 NN denotes DNA-binding
T1511 1699-1702 DT denotes The
T1512 1703-1718 JJ denotes transcriptional
T1513 1719-1727 NN denotes activity
T1514 1728-1730 IN denotes of
T1515 1731-1734 DT denotes the
T1516 1735-1740 NN denotes NF-κB
T1517 1741-1748 NN denotes complex
T1518 1749-1756 VB denotes depends
T1519 1757-1759 IN denotes on
T1520 1760-1765 NN denotes dimer
T1521 1766-1777 NN denotes composition
T1522 1778-1783 IN denotes since
T1523 1784-1794 JJ denotes C-terminal
T1524 1795-1804 JJ denotes unrelated
T1525 1805-1820 JJ denotes transcriptional
T1526 1821-1831 NN denotes activation
T1527 1832-1839 NN denotes domains
T1528 1840-1843 VB denotes are
T1529 1844-1851 JJ denotes present
T1530 1852-1863 RB denotes exclusively
T1531 1864-1866 IN denotes in
T1532 1867-1870 NN denotes p65
T1533 1870-1871 -COMMA- denotes ,
T1534 1872-1876 NN denotes RelB
T1535 1877-1880 CC denotes and
T1536 1881-1886 NN denotes c-Rel
T1537 1887-1888 -LRB- denotes (
T1538 1888-1889 CD denotes 2
T1539 1889-1890 -RRB- denotes )
T1540 1892-1902 NN denotes Inhibitors
T1541 1903-1905 IN denotes of
T1542 1906-1911 NN denotes NF-κB
T1543 1912-1913 -LRB- denotes (
T1544 1913-1916 NN denotes IκB
T1545 1916-1917 -RRB- denotes )
T1546 1918-1927 VB denotes associate
T1547 1928-1932 IN denotes with
T1548 1933-1936 DT denotes the
T1549 1937-1942 NN denotes NF-κB
T1550 1943-1950 NN denotes complex
T1551 1951-1954 CC denotes and
T1552 1955-1964 VB denotes interfere
T1553 1965-1969 IN denotes with
T1554 1970-1973 PRP-DOLLAR- denotes its
T1555 1974-1981 NN denotes binding
T1556 1982-1984 TO denotes to
T1557 1985-1988 NN denotes DNA
T1558 1989-1990 -LRB- denotes (
T1559 1990-1991 CD denotes 3
T1560 1991-1992 -RRB- denotes )
T1561 1994-1996 IN denotes In
T1562 1997-2000 DT denotes the
T1563 2001-2010 JJ denotes canonical
T1564 2011-2018 NN denotes pathway
T1565 2019-2021 IN denotes of
T1566 2022-2027 NN denotes NF-κB
T1567 2028-2038 NN denotes activation
T1568 2038-2039 -COMMA- denotes ,
T1569 2040-2043 DT denotes the
T1570 2044-2053 VB denotes activated
T1571 2054-2057 NN denotes IκB
T1572 2058-2064 NN denotes kinase
T1573 2065-2066 -LRB- denotes (
T1574 2066-2069 NN denotes IKK
T1575 2069-2070 -RRB- denotes )
T1576 2071-2085 VB denotes phosphorylates
T1577 2086-2089 NN denotes IκB
T1578 2090-2092 IN denotes at
T1579 2093-2101 JJ denotes specific
T1580 2102-2108 NN denotes serine
T1581 2109-2117 NN denotes residues
T1582 2118-2122 WDT denotes that
T1583 2123-2129 VB denotes target
T1584 2130-2133 DT denotes the
T1585 2134-2141 NN denotes protein
T1586 2142-2144 TO denotes to
T1587 2145-2159 NN denotes ubiquitination
T1588 2160-2163 CC denotes and
T1589 2164-2175 JJ denotes proteasomal
T1590 2176-2187 NN denotes degradation
T1591 2187-2188 -COMMA- denotes ,
T1592 2189-2194 WDT denotes which
T1593 2195-2203 VB denotes releases
T1594 2204-2207 DT denotes the
T1595 2208-2218 JJ denotes functional
T1596 2219-2224 NN denotes NF-κB
T1597 2225-2232 NN denotes complex
T1598 2233-2235 IN denotes in
T1599 2236-2239 DT denotes the
T1600 2240-2247 NN denotes nucleus
T1601 2249-2254 NN denotes IκB-α
T1602 2254-2255 -COMMA- denotes ,
T1603 2256-2259 DT denotes the
T1604 2260-2264 RB denotes most
T1605 2265-2273 JJ denotes abundant
T1606 2274-2283 NN denotes inhibitor
T1607 2284-2286 IN denotes of
T1608 2287-2292 NN denotes NF-κB
T1609 2293-2294 -LRB- denotes (
T1610 2294-2295 CD denotes 4
T1611 2295-2296 -RRB- denotes )
T1612 2296-2297 -COMMA- denotes ,
T1613 2298-2300 VB denotes is
T1614 2301-2315 VB denotes phosphorylated
T1615 2316-2318 IN denotes by
T1616 2319-2322 NN denotes IKK
T1617 2323-2325 IN denotes at
T1618 2326-2331 NN denotes Ser32
T1619 2332-2335 CC denotes and
T1620 2336-2341 NN denotes Ser36
T1621 2342-2343 -LRB- denotes (
T1622 2343-2344 CD denotes 5
T1623 2344-2345 -RRB- denotes )
T1624 2345-2346 -COMMA- denotes ,
T1625 2347-2350 CC denotes and
T1626 2351-2363 RB denotes subsequently
T1627 2364-2377 VB denotes ubiquitylated
T1628 2378-2380 IN denotes at
T1629 2381-2386 NN denotes Lys21
T1630 2387-2390 CC denotes and
T1631 2391-2396 NN denotes Lys22
T1632 2397-2399 TO denotes to
T1633 2400-2402 VB denotes be
T1634 2403-2411 VB denotes degraded
T1635 2412-2414 IN denotes by
T1636 2415-2418 DT denotes the
T1637 2419-2422 NN denotes 26S
T1638 2423-2433 NN denotes proteasome
T1639 2434-2435 -LRB- denotes (
T1640 2435-2436 CD denotes 6
T1641 2436-2437 -RRB- denotes )
T1642 2439-2442 DT denotes The
T1643 2443-2448 NN denotes NF-κB
T1644 2449-2457 NN denotes activity
T1645 2458-2460 VB denotes is
T1646 2461-2469 VB denotes enhanced
T1647 2470-2472 IN denotes by
T1648 2473-2488 NN denotes phosphorylation
T1649 2489-2491 IN denotes of
T1650 2492-2495 NN denotes p65
T1651 2496-2498 IN denotes at
T1652 2499-2505 NN denotes Ser276
T1653 2506-2508 IN denotes by
T1654 2509-2512 NN denotes PKA
T1655 2513-2516 CC denotes and
T1656 2517-2521 NN denotes MSK1
T1657 2522-2523 -LRB- denotes (
T1658 2523-2526 NN denotes 7,8
T1659 2526-2527 -RRB- denotes )
T1660 2527-2528 -COMMA- denotes ,
T1661 2529-2535 NN denotes Ser311
T1662 2536-2538 IN denotes by
T1663 2539-2543 NN denotes PKCζ
T1664 2544-2545 -LRB- denotes (
T1665 2545-2546 CD denotes 9
T1666 2546-2547 -RRB- denotes )
T1667 2548-2551 CC denotes and
T1668 2552-2558 NN denotes Ser536
T1669 2559-2561 IN denotes by
T1670 2562-2566 NN denotes IKKα
T1671 2567-2568 -LRB- denotes (
T1672 2568-2573 CD denotes 10,11
T1673 2573-2574 -RRB- denotes )
T1674 2576-2587 NN denotes Acetylation
T1675 2588-2590 IN denotes of
T1676 2591-2594 NN denotes p65
T1677 2595-2597 IN denotes at
T1678 2598-2604 NN denotes Lys218
T1679 2605-2608 CC denotes and
T1680 2609-2615 NN denotes Lys221
T1681 2616-2625 VB denotes increases
T1682 2626-2629 DT denotes the
T1683 2630-2633 NN denotes DNA
T1684 2634-2641 NN denotes binding
T1685 2642-2645 CC denotes and
T1686 2646-2653 VB denotes impairs
T1687 2654-2657 DT denotes the
T1688 2658-2669 NN denotes association
T1689 2670-2674 IN denotes with
T1690 2675-2680 NN denotes IκB-α
T1691 2680-2681 -COMMA- denotes ,
T1692 2682-2685 CC denotes and
T1693 2686-2697 NN denotes acetylation
T1694 2698-2700 IN denotes at
T1695 2701-2707 NN denotes Lys310
T1696 2708-2716 VB denotes enhances
T1697 2717-2720 DT denotes the
T1698 2721-2724 NN denotes p65
T1699 2725-2740 JJ denotes transcriptional
T1700 2741-2749 NN denotes activity
T1701 2750-2751 -LRB- denotes (
T1702 2751-2756 CD denotes 12,13
T1703 2756-2757 -RRB- denotes )
T1704 2759-2774 NN denotes Post-activation
T1705 2775-2779 VB denotes turn
T1706 2780-2783 RP denotes off
T1707 2784-2786 IN denotes of
T1708 2787-2792 NN denotes NF-κB
T1709 2793-2795 VB denotes is
T1710 2796-2805 VB denotes regulated
T1711 2806-2808 IN denotes by
T1712 2809-2817 JJ denotes negative
T1713 2818-2826 NN denotes feedback
T1714 2827-2831 NN denotes loop
T1715 2832-2839 IN denotes through
T1716 2840-2850 NN denotes inhibitors
T1717 2851-2856 IN denotes under
T1718 2857-2860 DT denotes the
T1719 2861-2876 JJ denotes transcriptional
T1720 2877-2884 NN denotes control
T1721 2885-2887 IN denotes of
T1722 2888-2893 NN denotes NF-κB
T1723 2893-2894 -COMMA- denotes ,
T1724 2895-2899 JJ denotes such
T1725 2900-2902 IN denotes as
T1726 2903-2908 JJ denotes IκB-α
T1727 2909-2912 CC denotes and
T1728 2913-2930 JJ denotes ubiquitin-editing
T1729 2931-2938 NN denotes protein
T1730 2939-2942 NN denotes A20
T1731 2943-2944 -LRB- denotes (
T1732 2944-2949 CD denotes 14–20
T1733 2949-2950 -RRB- denotes )
T1734 2952-2965 NN denotes Deacetylation
T1735 2966-2968 IN denotes of
T1736 2969-2972 NN denotes p65
T1737 2973-2975 IN denotes by
T1738 2976-2983 NN denotes histone
T1739 2984-2997 NN denotes deacetylase-3
T1740 2998-3000 CC denotes or
T1741 3001-3006 NN denotes SIRT1
T1742 3006-3007 -COMMA- denotes ,
T1743 3008-3010 CC denotes or
T1744 3011-3022 NN denotes acetylation
T1745 3023-3025 IN denotes of
T1746 3026-3029 NN denotes p65
T1747 3030-3032 IN denotes at
T1748 3033-3039 NN denotes Lys122
T1749 3040-3043 CC denotes and
T1750 3044-3050 NN denotes Lys123
T1751 3051-3064 VB denotes down-regulate
T1752 3065-3068 DT denotes the
T1753 3069-3074 NN denotes NF-κB
T1754 3075-3083 NN denotes activity
T1755 3084-3085 -LRB- denotes (
T1756 3085-3093 CD denotes 12,21,22
T1757 3093-3094 -RRB- denotes )
T1758 3096-3106 JJ denotes Persistent
T1759 3107-3117 NN denotes activation
T1760 3118-3120 IN denotes of
T1761 3121-3126 NN denotes NF-κB
T1762 3127-3133 VB denotes occurs
T1763 3134-3136 IN denotes in
T1764 3137-3142 JJ denotes human
T1765 3143-3159 NN denotes immunodeficiency
T1766 3160-3167 NN denotes virus-1
T1767 3168-3169 -LRB- denotes (
T1768 3169-3174 NN denotes HIV-1
T1769 3174-3175 -RRB- denotes )
T1770 3175-3184 JJ denotes -infected
T1771 3185-3194 NN denotes monocytes
T1772 3194-3195 -COMMA- denotes ,
T1773 3196-3207 NN denotes macrophages
T1774 3208-3211 CC denotes and
T1775 3212-3221 NN denotes microglia
T1776 3221-3222 -COMMA- denotes ,
T1777 3223-3226 CC denotes and
T1778 3227-3235 VB denotes enhances
T1779 3236-3239 DT denotes the
T1780 3240-3250 NN denotes expression
T1781 3251-3253 IN denotes of
T1782 3254-3270 JJ denotes NF-κB-responsive
T1783 3271-3276 NN denotes genes
T1784 3276-3277 -COMMA- denotes ,
T1785 3278-3287 VB denotes including
T1786 3288-3304 JJ denotes pro-inflammatory
T1787 3305-3314 NN denotes cytokines
T1788 3314-3315 -COMMA- denotes ,
T1789 3316-3320 NN denotes cell
T1790 3321-3329 NN denotes adhesion
T1791 3330-3339 NN denotes molecules
T1792 3340-3343 CC denotes and
T1793 3344-3354 NN denotes chemokines
T1794 3355-3356 -LRB- denotes (
T1795 3356-3361 CD denotes 23–25
T1796 3361-3362 -RRB- denotes )
T1797 3364-3371 JJ denotes Chronic
T1798 3372-3384 NN denotes inflammation
T1799 3385-3387 VB denotes is
T1800 3388-3389 DT denotes a
T1801 3390-3395 JJ denotes major
T1802 3396-3401 NN denotes cause
T1803 3402-3404 IN denotes of
T1804 3405-3411 JJ denotes immune
T1805 3412-3415 CC denotes and
T1806 3416-3422 NN denotes neuron
T1807 3423-3434 NN denotes dysfunction
T1808 3435-3437 IN denotes in
T1809 3438-3442 NN denotes AIDS
T1810 3443-3444 -LRB- denotes (
T1811 3444-3449 CD denotes 26,27
T1812 3449-3450 -RRB- denotes )
T1813 3452-3464 RB denotes Consistently
T1814 3464-3465 -COMMA- denotes ,
T1815 3466-3475 JJ denotes non-human
T1816 3476-3483 JJ denotes primate
T1817 3484-3489 NN denotes hosts
T1818 3490-3493 IN denotes for
T1819 3494-3500 JJ denotes simian
T1820 3501-3517 NN denotes immunodeficiency
T1821 3518-3523 NN denotes virus
T1822 3523-3524 -COMMA- denotes ,
T1823 3525-3529 JJ denotes such
T1824 3530-3532 IN denotes as
T1825 3533-3540 JJ denotes African
T1826 3541-3546 JJ denotes green
T1827 3547-3554 NN denotes monkeys
T1828 3555-3558 CC denotes and
T1829 3559-3564 JJ denotes sooty
T1830 3565-3573 NN denotes mangabey
T1831 3573-3574 -COMMA- denotes ,
T1832 3575-3579 VB denotes lack
T1833 3580-3588 JJ denotes aberrant
T1834 3589-3595 JJ denotes immune
T1835 3596-3606 NN denotes activation
T1836 3607-3610 CC denotes and
T1837 3611-3613 VB denotes do
T1838 3614-3617 RB denotes not
T1839 3618-3625 VB denotes develop
T1840 3626-3630 NN denotes AIDS
T1841 3631-3638 IN denotes despite
T1842 3639-3643 JJ denotes high
T1843 3644-3649 NN denotes virus
T1844 3650-3661 NN denotes replication
T1845 3662-3663 -LRB- denotes (
T1846 3663-3668 CD denotes 28,29
T1847 3668-3669 -RRB- denotes )
T1848 3671-3675 RB denotes Thus
T1849 3675-3676 -COMMA- denotes ,
T1850 3677-3690 VB denotes understanding
T1851 3691-3694 DT denotes the
T1852 3695-3705 NN denotes mechanisms
T1853 3706-3708 IN denotes of
T1854 3709-3714 NN denotes NF-κB
T1855 3715-3727 NN denotes deregulation
T1856 3728-3730 IN denotes by
T1857 3731-3736 NN denotes HIV-1
T1858 3737-3740 MD denotes may
T1859 3741-3748 VB denotes provide
T1860 3749-3756 JJ denotes further
T1861 3757-3765 NN denotes insights
T1862 3766-3770 IN denotes into
T1863 3771-3775 NN denotes AIDS
T1864 3776-3788 NN denotes pathogenesis
T1865 3790-3792 IN denotes In
T1866 3793-3798 NN denotes HIV-1
T1867 3799-3804 NN denotes entry
T1868 3804-3805 -COMMA- denotes ,
T1869 3806-3809 DT denotes the
T1870 3810-3817 NN denotes binding
T1871 3818-3820 IN denotes of
T1872 3821-3824 DT denotes the
T1873 3825-3830 NN denotes gp120
T1874 3831-3836 JJ denotes viral
T1875 3837-3845 NN denotes envelope
T1876 3846-3848 TO denotes to
T1877 3849-3852 NN denotes CD4
T1878 3853-3860 VB denotes induces
T1879 3861-3864 DT denotes the
T1880 3865-3870 NN denotes NF-κB
T1881 3871-3879 NN denotes activity
T1882 3880-3882 IN denotes by
T1883 3883-3893 NN denotes activation
T1884 3894-3896 IN denotes of
T1885 3897-3900 NN denotes IKK
T1886 3901-3902 -LRB- denotes (
T1887 3902-3904 CD denotes 30
T1888 3904-3905 -RRB- denotes )
T1889 3906-3909 CC denotes and
T1890 3910-3920 NN denotes procaspase
T1891 3921-3922 CD denotes 8
T1892 3923-3924 -LRB- denotes (
T1893 3924-3926 CD denotes 31
T1894 3926-3927 -RRB- denotes )
T1895 3929-3938 VB denotes Following
T1896 3939-3944 JJ denotes viral
T1897 3945-3956 NN denotes integration
T1898 3956-3957 -COMMA- denotes ,
T1899 3958-3961 DT denotes the
T1900 3962-3967 JJ denotes early
T1901 3968-3975 VB denotes encoded
T1902 3976-3981 NN denotes HIV-1
T1903 3982-3985 NN denotes Tat
T1904 3986-3993 NN denotes protein
T1905 3994-4003 VB denotes interacts
T1906 4004-4008 IN denotes with
T1907 4009-4012 DT denotes the
T1908 4013-4018 NN denotes HIV-1
T1909 4019-4022 NN denotes RNA
T1910 4023-4026 CC denotes and
T1911 4027-4031 NN denotes host
T1912 4032-4036 NN denotes cell
T1913 4037-4044 NN denotes factors
T1914 4045-4047 TO denotes to
T1915 4048-4055 VB denotes sustain
T1916 4056-4059 DT denotes the
T1917 4060-4065 JJ denotes viral
T1918 4066-4077 NN denotes replication
T1919 4079-4082 NN denotes Tat
T1920 4083-4088 VB denotes binds
T1921 4089-4091 TO denotes to
T1922 4092-4095 NN denotes RNA
T1923 4096-4105 JJ denotes stem-loop
T1924 4106-4116 NN denotes structures
T1925 4117-4126 VB denotes generated
T1926 4127-4129 IN denotes by
T1927 4130-4133 DT denotes the
T1928 4134-4136 NN denotes 5′
T1929 4137-4140 NN denotes end
T1930 4141-4143 IN denotes of
T1931 4144-4150 NN denotes target
T1932 4151-4162 NN denotes transcripts
T1933 4162-4163 -COMMA- denotes ,
T1934 4164-4173 VB denotes including
T1935 4174-4177 DT denotes the
T1936 4178-4183 NN denotes HIV-1
T1937 4184-4210 JJ denotes transactivation-responsive
T1938 4211-4218 NN denotes element
T1939 4219-4220 -LRB- denotes (
T1940 4220-4223 NN denotes TAR
T1941 4223-4224 -RRB- denotes )
T1942 4225-4226 -LRB- denotes (
T1943 4226-4228 CD denotes 32
T1944 4228-4229 -RRB- denotes )
T1945 4229-4230 -COMMA- denotes ,
T1946 4231-4236 NN denotes tumor
T1947 4237-4245 NN denotes necrosis
T1948 4246-4252 NN denotes factor
T1949 4253-4254 NN denotes β
T1950 4255-4256 -LRB- denotes (
T1951 4256-4260 NN denotes TNFβ
T1952 4260-4261 -RRB- denotes )
T1953 4262-4263 -LRB- denotes (
T1954 4263-4265 CD denotes 33
T1955 4265-4266 -RRB- denotes )
T1956 4267-4270 CC denotes and
T1957 4271-4284 NN denotes interleukin-6
T1958 4285-4286 -LRB- denotes (
T1959 4286-4290 NN denotes IL-6
T1960 4290-4291 -RRB- denotes )
T1961 4292-4293 -LRB- denotes (
T1962 4293-4295 CD denotes 34
T1963 4295-4296 -RRB- denotes )
T1964 4297-4299 TO denotes to
T1965 4300-4308 VB denotes activate
T1966 4309-4313 NN denotes gene
T1967 4314-4327 NN denotes transcription
T1968 4329-4335 RB denotes Indeed
T1969 4335-4336 -COMMA- denotes ,
T1970 4337-4340 NN denotes Tat
T1971 4341-4349 VB denotes promotes
T1972 4350-4353 DT denotes the
T1973 4354-4369 JJ denotes transcriptional
T1974 4370-4380 NN denotes initiation
T1975 4381-4384 CC denotes and
T1976 4385-4395 NN denotes elongation
T1977 4396-4398 IN denotes by
T1978 4399-4410 VB denotes interacting
T1979 4411-4415 IN denotes with
T1980 4416-4427 VB denotes transacting
T1981 4428-4435 NN denotes factors
T1982 4436-4439 CC denotes and
T1983 4440-4449 NN denotes cofactors
T1984 4449-4450 -COMMA- denotes ,
T1985 4451-4455 JJ denotes such
T1986 4456-4458 IN denotes as
T1987 4459-4462 NN denotes Sp1
T1988 4463-4464 -LRB- denotes (
T1989 4464-4466 CD denotes 35
T1990 4466-4467 -RRB- denotes )
T1991 4467-4468 -COMMA- denotes ,
T1992 4469-4474 NN denotes TFIID
T1993 4475-4476 -LRB- denotes (
T1994 4476-4478 CD denotes 36
T1995 4478-4479 -RRB- denotes )
T1996 4479-4480 -COMMA- denotes ,
T1997 4481-4486 NN denotes E2F-4
T1998 4487-4488 -LRB- denotes (
T1999 4488-4490 CD denotes 37
T2000 4490-4491 -RRB- denotes )
T2001 4491-4492 -COMMA- denotes ,
T2002 4493-4499 NN denotes C/EBPβ
T2003 4500-4501 -LRB- denotes (
T2004 4501-4503 CD denotes 38
T2005 4503-4504 -RRB- denotes )
T2006 4504-4505 -COMMA- denotes ,
T2007 4506-4512 NN denotes cyclin
T2008 4513-4520 NN denotes T1/CDK9
T2009 4521-4522 -LRB- denotes (
T2010 4522-4527 CD denotes 39,40
T2011 4527-4528 -RRB- denotes )
T2012 4529-4532 CC denotes and
T2013 4533-4536 DT denotes the
T2014 4537-4544 NN denotes histone
T2015 4545-4563 NN denotes acetyltransferases
T2016 4564-4572 NN denotes p300/CBP
T2017 4573-4576 CC denotes and
T2018 4577-4582 NN denotes P/CAF
T2019 4583-4584 -LRB- denotes (
T2020 4584-4589 CD denotes 41–43
T2021 4589-4590 -RRB- denotes )
T2022 4592-4596 WRB denotes When
T2023 4597-4605 VB denotes released
T2024 4606-4610 IN denotes from
T2025 4611-4625 JJ denotes HIV-1-infected
T2026 4626-4631 NN denotes cells
T2027 4631-4632 -COMMA- denotes ,
T2028 4633-4636 NN denotes Tat
T2029 4637-4648 VB denotes deregulates
T2030 4649-4652 DT denotes the
T2031 4653-4657 NN denotes cell
T2032 4658-4667 NN denotes signaling
T2033 4668-4670 IN denotes by
T2034 4671-4678 VB denotes binding
T2035 4679-4681 TO denotes to
T2036 4682-4686 NN denotes cell
T2037 4687-4696 NN denotes receptors
T2038 4696-4697 -COMMA- denotes ,
T2039 4698-4702 JJ denotes such
T2040 4703-4705 IN denotes as
T2041 4706-4715 NN denotes integrins
T2042 4716-4717 -LRB- denotes (
T2043 4717-4719 CD denotes 44
T2044 4719-4720 -RRB- denotes )
T2045 4720-4721 -COMMA- denotes ,
T2046 4722-4730 NN denotes Flk1/KDR
T2047 4731-4739 NN denotes receptor
T2048 4740-4741 -LRB- denotes (
T2049 4741-4743 CD denotes 45
T2050 4743-4744 -RRB- denotes )
T2051 4745-4748 CC denotes and
T2052 4749-4758 NN denotes chemokine
T2053 4759-4768 NN denotes receptors
T2054 4769-4770 -LRB- denotes (
T2055 4770-4772 CD denotes 46
T2056 4772-4773 -RRB- denotes )
T2057 4775-4777 PRP denotes We
T2058 4778-4783 RB denotes first
T2059 4784-4792 VB denotes reported
T2060 4793-4797 IN denotes that
T2061 4798-4803 NN denotes NF-κB
T2062 4804-4807 VB denotes was
T2063 4808-4822 RB denotes constitutively
T2064 4823-4829 JJ denotes active
T2065 4830-4832 IN denotes in
T2066 4833-4839 NN denotes Jurkat
T2067 4840-4845 NN denotes cells
T2068 4846-4850 WDT denotes that
T2069 4851-4857 RB denotes stably
T2070 4858-4867 VB denotes expressed
T2071 4868-4871 DT denotes the
T2072 4872-4875 NN denotes Tat
T2073 4876-4880 NN denotes gene
T2074 4881-4882 -LRB- denotes (
T2075 4882-4884 CD denotes 47
T2076 4884-4885 -RRB- denotes )
T2077 4887-4896 VB denotes Following
T2078 4897-4901 NN denotes gene
T2079 4902-4914 NN denotes transfection
T2080 4915-4917 CC denotes or
T2081 4918-4925 NN denotes protein
T2082 4926-4938 NN denotes transduction
T2083 4938-4939 -COMMA- denotes ,
T2084 4940-4943 NN denotes Tat
T2085 4944-4951 VB denotes induced
T2086 4952-4955 DT denotes the
T2087 4956-4959 NN denotes IKK
T2088 4960-4968 NN denotes activity
T2089 4969-4972 CC denotes and
T2090 4973-4984 JJ denotes proteasomal
T2091 4985-4996 NN denotes degradation
T2092 4997-4999 IN denotes of
T2093 5000-5005 NN denotes IκB-α
T2094 5006-5007 -LRB- denotes (
T2095 5007-5009 CD denotes 48
T2096 5009-5010 -RRB- denotes )
T2097 5010-5011 -COMMA- denotes ,
T2098 5012-5015 CC denotes and
T2099 5016-5025 VB denotes increased
T2100 5026-5029 DT denotes the
T2101 5030-5033 NN denotes p65
T2102 5034-5049 JJ denotes transcriptional
T2103 5050-5058 NN denotes activity
T2104 5059-5061 IN denotes by
T2105 5062-5072 VB denotes inhibiting
T2106 5073-5076 DT denotes the
T2107 5077-5092 JJ denotes SIRT-1-mediated
T2108 5093-5106 NN denotes deacetylation
T2109 5107-5109 IN denotes of
T2110 5110-5113 NN denotes p65
T2111 5114-5120 NN denotes Lys310
T2112 5121-5122 -LRB- denotes (
T2113 5122-5124 CD denotes 49
T2114 5124-5125 -RRB- denotes )
T2115 5127-5132 DT denotes These
T2116 5133-5141 NN denotes findings
T2117 5142-5151 VB denotes suggested
T2118 5152-5156 IN denotes that
T2119 5157-5160 NN denotes Tat
T2120 5161-5170 VB denotes modulates
T2121 5171-5178 JJ denotes crucial
T2122 5179-5186 NN denotes enzymes
T2123 5187-5195 VB denotes involved
T2124 5196-5198 IN denotes in
T2125 5199-5204 NN denotes NF-κB
T2126 5205-5214 NN denotes signaling
T2127 5214-5215 -COLON- denotes ;
T2128 5216-5223 RB denotes however
T2129 5223-5224 -COMMA- denotes ,
T2130 5225-5227 PRP denotes it
T2131 5228-5231 VB denotes was
T2132 5232-5239 JJ denotes unclear
T2133 5240-5243 WRB denotes how
T2134 5244-5247 NN denotes Tat
T2135 5248-5253 MD denotes could
T2136 5254-5261 VB denotes subvert
T2137 5262-5265 DT denotes the
T2138 5266-5274 JJ denotes negative
T2139 5275-5283 NN denotes feedback
T2140 5284-5286 IN denotes of
T2141 5287-5292 NN denotes NF-κB
T2142 5292-5293 -COMMA- denotes ,
T2143 5294-5299 WDT denotes which
T2144 5300-5302 VB denotes is
T2145 5303-5309 RB denotes mainly
T2146 5310-5319 JJ denotes dependent
T2147 5320-5322 IN denotes on
T2148 5323-5325 FW denotes de
T2149 5326-5330 FW denotes novo
T2150 5331-5340 NN denotes synthesis
T2151 5341-5343 IN denotes of
T2152 5344-5349 NN denotes IκB-α
T2153 5350-5351 -LRB- denotes (
T2154 5351-5356 CD denotes 15,17
T2155 5356-5357 -RRB- denotes )
T2156 5359-5361 PRP denotes We
T2157 5362-5372 RB denotes previously
T2158 5373-5378 VB denotes found
T2159 5379-5383 IN denotes that
T2160 5384-5389 NN denotes IκB-α
T2161 5390-5395 VB denotes binds
T2162 5396-5398 TO denotes to
T2163 5399-5402 NN denotes Tat
T2164 5403-5406 CC denotes and
T2165 5407-5415 VB denotes promotes
T2166 5416-5419 DT denotes the
T2167 5420-5427 JJ denotes nuclear
T2168 5428-5434 NN denotes export
T2169 5435-5437 IN denotes of
T2170 5438-5441 DT denotes the
T2171 5442-5447 JJ denotes viral
T2172 5448-5462 NN denotes transactivator
T2173 5463-5464 -LRB- denotes (
T2174 5464-5469 CD denotes 50,51
T2175 5469-5470 -RRB- denotes )
T2176 5472-5474 IN denotes In
T2177 5475-5479 DT denotes this
T2178 5480-5485 NN denotes study
T2179 5485-5486 -COMMA- denotes ,
T2180 5487-5489 PRP denotes we
T2181 5490-5496 VB denotes report
T2182 5497-5501 IN denotes that
T2183 5502-5505 NN denotes Tat
T2184 5506-5517 VB denotes counteracts
T2185 5518-5521 DT denotes the
T2186 5522-5537 JJ denotes post-activation
T2187 5538-5542 NN denotes turn
T2188 5543-5546 RP denotes off
T2189 5547-5549 IN denotes of
T2190 5550-5555 NN denotes NF-κB
T2191 5556-5563 IN denotes through
T2192 5564-5570 JJ denotes direct
T2193 5571-5582 NN denotes interaction
T2194 5583-5587 IN denotes with
T2195 5588-5593 NN denotes IκB-α
T2196 5594-5597 CC denotes and
T2197 5598-5601 NN denotes p65
T2198 5601-5602 -COMMA- denotes ,
T2199 5603-5608 WDT denotes which
T2200 5609-5617 VB denotes enhances
T2201 5618-5621 DT denotes the
T2202 5622-5625 NN denotes DNA
T2203 5626-5633 NN denotes binding
T2204 5634-5637 CC denotes and
T2205 5638-5653 JJ denotes transcriptional
T2206 5654-5662 NN denotes activity
T2207 5663-5665 IN denotes of
T2208 5666-5669 DT denotes the
T2209 5670-5675 NN denotes NF-κB
T2210 5676-5683 NN denotes complex
T2211 5685-5688 DT denotes The
T2212 5689-5692 JJ denotes new
T2213 5693-5702 NN denotes mechanism
T2214 5703-5705 IN denotes of
T2215 5706-5711 NN denotes NF-κB
T2216 5712-5724 NN denotes deregulation
T2217 5725-5729 RB denotes here
T2218 5730-5739 VB denotes described
T2219 5740-5743 MD denotes may
T2220 5744-5751 VB denotes provide
T2221 5752-5759 JJ denotes further
T2222 5760-5768 NN denotes insights
T2223 5769-5773 IN denotes into
T2224 5774-5777 DT denotes the
T2225 5778-5785 JJ denotes chronic
T2226 5786-5792 JJ denotes immune
T2227 5793-5803 NN denotes activation
T2228 5804-5806 IN denotes of
T2229 5807-5812 NN denotes HIV-1
T2230 5813-5822 NN denotes infection
T4413 5848-5856 NN denotes Plasmids
T4414 5857-5860 DT denotes The
T4415 5861-5869 NN denotes plasmids
T4416 5870-5886 NN denotes pcDNA-3xHA-IκB-α
T4417 5886-5887 -COMMA- denotes ,
T4418 5888-5903 NN denotes p3xFLAG-CMV-Tat
T4419 5903-5904 -COMMA- denotes ,
T4420 5905-5920 NN denotes p3xFLAG-CMV-Tat
T4421 5921-5922 NN denotes C
T4422 5922-5923 -LRB- denotes (
T4423 5923-5931 CD denotes 22,25,27
T4424 5931-5932 -RRB- denotes )
T4425 5932-5933 NN denotes A
T4426 5933-5934 -COMMA- denotes ,
T4427 5935-5950 NN denotes p3xFLAG-CMV-Tat
T4428 5951-5952 NN denotes R
T4429 5952-5953 -LRB- denotes (
T4430 5953-5970 CD denotes 49,52,53,55,56,57
T4431 5970-5971 -RRB- denotes )
T4432 5971-5972 NN denotes A
T4433 5972-5973 -COMMA- denotes ,
T4434 5974-5985 NN denotes pGEX-2T-Tat
T4435 5985-5986 -COMMA- denotes ,
T4436 5987-5998 NN denotes pGEX-2T-Tat
T4437 5999-6000 NN denotes C
T4438 6000-6001 -LRB- denotes (
T4439 6001-6009 CD denotes 22,25,27
T4440 6009-6010 -RRB- denotes )
T4441 6010-6011 NN denotes A
T4442 6012-6015 CC denotes and
T4443 6016-6027 NN denotes pGEX-2T-Tat
T4444 6028-6029 NN denotes R
T4445 6029-6030 -LRB- denotes (
T4446 6030-6047 CD denotes 49,52,53,55,56,57
T4447 6047-6048 -RRB- denotes )
T4448 6048-6049 NN denotes A
T4449 6050-6054 VB denotes were
T4450 6055-6065 RB denotes previously
T4451 6066-6075 VB denotes described
T4452 6076-6077 -LRB- denotes (
T4453 6077-6079 CD denotes 50
T4454 6079-6080 -RRB- denotes )
T4455 6082-6085 DT denotes The
T4456 6086-6094 NN denotes plasmids
T4457 6095-6110 NN denotes pNL4-3.Luc.R-E-
T4458 6111-6114 CC denotes and
T4459 6115-6124 NN denotes pHXB2-env
T4460 6125-6129 VB denotes were
T4461 6130-6138 VB denotes obtained
T4462 6139-6143 IN denotes from
T4463 6144-6147 DT denotes the
T4464 6148-6152 NNP denotes AIDS
T4465 6153-6161 NNP denotes Research
T4466 6162-6163 CC denotes &
T4467 6164-6173 NNP denotes Reference
T4468 6174-6181 NNP denotes Reagent
T4469 6182-6189 NNP denotes Program
T4470 6189-6190 -COMMA- denotes ,
T4471 6191-6199 NNP denotes Division
T4472 6200-6202 IN denotes of
T4473 6203-6207 NNP denotes AIDS
T4474 6207-6208 -COMMA- denotes ,
T4475 6209-6214 NNP denotes NIAID
T4476 6214-6215 -COMMA- denotes ,
T4477 6216-6219 NNP denotes NIH
T4478 6219-6220 -COMMA- denotes ,
T4479 6221-6224 NNP denotes USA
T4480 6224-6225 -COLON- denotes ;
T4481 6226-6232 NN denotes pκBluc
T4482 6233-6236 CC denotes and
T4483 6237-6246 NN denotes pSV-β-Gal
T4484 6247-6251 VB denotes were
T4485 6252-6261 VB denotes purchased
T4486 6262-6266 IN denotes from
T4487 6267-6274 NNP denotes Promega
T4488 6275-6276 -LRB- denotes (
T4489 6276-6283 NNP denotes Madison
T4490 6283-6284 -COMMA- denotes ,
T4491 6285-6287 NNP denotes WI
T4492 6287-6288 -COMMA- denotes ,
T4493 6289-6292 NNP denotes USA
T4494 6292-6293 -RRB- denotes )
T4495 6295-6298 DT denotes The
T4496 6299-6307 NN denotes plasmids
T4497 6308-6324 NN denotes pRc/CMV-3xHA-p65
T4498 6324-6325 -COMMA- denotes ,
T4499 6326-6344 NN denotes pRc/CMV-3xHA-p65ΔC
T4500 6344-6345 -LRB- denotes (
T4501 6345-6350 CD denotes 1–318
T4502 6350-6351 -RRB- denotes )
T4503 6351-6352 -COMMA- denotes ,
T4504 6353-6371 NN denotes pRc/CMV-3xHA-p65ΔN
T4505 6371-6372 -LRB- denotes (
T4506 6372-6379 CD denotes 122–551
T4507 6379-6380 -RRB- denotes )
T4508 6380-6381 -COMMA- denotes ,
T4509 6382-6397 NN denotes p3xFLAG-CMV-Tat
T4510 6398-6399 NN denotes T
T4511 6399-6400 -COMMA- denotes ,
T4512 6400-6401 NN denotes N
T4513 6401-6402 -LRB- denotes (
T4514 6402-6407 CD denotes 23,24
T4515 6407-6408 -RRB- denotes )
T4516 6408-6409 NN denotes A
T4517 6409-6410 -COMMA- denotes ,
T4518 6411-6426 NN denotes p3xFLAG-CMV-Tat
T4519 6427-6428 NN denotes K
T4520 6428-6429 -LRB- denotes (
T4521 6429-6434 CD denotes 50,51
T4522 6434-6435 -RRB- denotes )
T4523 6435-6436 NN denotes A
T4524 6436-6437 -COMMA- denotes ,
T4525 6438-6449 NN denotes pGEX-2T-Tat
T4526 6450-6451 NN denotes T
T4527 6451-6452 -COMMA- denotes ,
T4528 6452-6453 NN denotes N
T4529 6453-6454 -LRB- denotes (
T4530 6454-6459 CD denotes 23,24
T4531 6459-6460 -RRB- denotes )
T4532 6460-6461 NN denotes A
T4533 6461-6462 -COMMA- denotes ,
T4534 6463-6474 NN denotes pGEX-2T-Tat
T4535 6475-6476 NN denotes K
T4536 6476-6477 -LRB- denotes (
T4537 6477-6482 CD denotes 50,51
T4538 6482-6483 -RRB- denotes )
T4539 6483-6484 NN denotes A
T4540 6485-6488 CC denotes and
T4541 6489-6509 NN denotes pNL4-3.FLAG-Tat.R-E-
T4542 6510-6514 VB denotes were
T4543 6515-6524 VB denotes generated
T4544 6525-6527 IN denotes as
T4545 6528-6537 VB denotes described
T4546 6538-6540 IN denotes in
T4547 6541-6554 NNP denotes Supplementary
T4548 6555-6559 NNP denotes Data
T4915 6562-6567 NN denotes Cells
T4916 6567-6568 -COMMA- denotes ,
T4917 6569-6581 NN denotes transfection
T4918 6581-6582 -COMMA- denotes ,
T4919 6583-6593 NN denotes treatments
T4920 6594-6597 CC denotes and
T4921 6598-6608 NN denotes luciferase
T4922 6609-6614 NN denotes assay
T4923 6615-6619 NN denotes HeLa
T4924 6619-6620 -COMMA- denotes ,
T4925 6621-6633 NN denotes p50−/−p65−/−
T4926 6634-6639 NN denotes mouse
T4927 6640-6649 JJ denotes embryonic
T4928 6650-6661 NN denotes fibroblasts
T4929 6662-6663 -LRB- denotes (
T4930 6663-6667 NN denotes MEFs
T4931 6667-6668 -RRB- denotes )
T4932 6669-6670 -LRB- denotes (
T4933 6670-6672 CD denotes 52
T4934 6672-6673 -RRB- denotes )
T4935 6674-6677 CC denotes and
T4936 6678-6682 NN denotes 293T
T4937 6683-6688 NN denotes cells
T4938 6689-6693 VB denotes were
T4939 6694-6702 VB denotes cultured
T4940 6703-6705 IN denotes in
T4941 6706-6714 NNP denotes Dulbecco
T4942 6714-6716 POS denotes 's
T4943 6717-6725 VB denotes modified
T4944 6726-6731 NNP denotes Eagle
T4945 6731-6733 POS denotes 's
T4946 6734-6740 NN denotes medium
T4947 6740-6741 -COLON- denotes ;
T4948 6742-6748 NN denotes Jurkat
T4949 6748-6749 -COMMA- denotes ,
T4950 6750-6754 NN denotes U937
T4951 6755-6760 NN denotes cells
T4952 6761-6764 CC denotes and
T4953 6765-6770 JJ denotes human
T4954 6771-6781 JJ denotes peripheral
T4955 6782-6787 NN denotes blood
T4956 6788-6799 JJ denotes mononuclear
T4957 6800-6805 NN denotes cells
T4958 6806-6807 -LRB- denotes (
T4959 6807-6812 NN denotes PBMCs
T4960 6812-6813 -RRB- denotes )
T4961 6814-6818 VB denotes were
T4962 6819-6827 VB denotes cultured
T4963 6828-6830 IN denotes in
T4964 6831-6835 NN denotes RPMI
T4965 6836-6840 CD denotes 1640
T4966 6842-6847 NN denotes PBMCs
T4967 6848-6852 VB denotes were
T4968 6853-6861 VB denotes isolated
T4969 6862-6864 IN denotes as
T4970 6865-6875 RB denotes previously
T4971 6876-6885 VB denotes described
T4972 6886-6887 -LRB- denotes (
T4973 6887-6889 CD denotes 53
T4974 6889-6890 -RRB- denotes )
T4975 6892-6897 NN denotes Media
T4976 6898-6902 VB denotes were
T4977 6903-6915 VB denotes supplemented
T4978 6916-6920 IN denotes with
T4979 6921-6923 CD denotes 10
T4980 6923-6924 NN denotes %
T4981 6925-6941 JJ denotes heat-inactivated
T4982 6942-6947 JJ denotes fetal
T4983 6948-6952 NN denotes calf
T4984 6953-6958 NN denotes serum
T4985 6959-6962 CC denotes and
T4986 6963-6967 NN denotes 2 mM
T4987 6968-6979 NN denotes l-glutamine
T4988 6980-6981 -LRB- denotes (
T4989 6981-6986 NNP denotes Lonza
T4990 6987-6994 NNP denotes Cologne
T4991 6995-6997 NNP denotes AG
T4992 6997-6998 -COMMA- denotes ,
T4993 6999-7006 NNP denotes Germany
T4994 7006-7007 -RRB- denotes )
T4995 7009-7013 NN denotes HeLa
T4996 7013-7014 -COMMA- denotes ,
T4997 7015-7027 NN denotes p50−/−p65−/−
T4998 7028-7032 NN denotes MEFs
T4999 7033-7036 CC denotes and
T5000 7037-7041 NN denotes 293T
T5001 7042-7046 VB denotes were
T5002 7047-7058 VB denotes transfected
T5003 7059-7063 IN denotes with
T5004 7064-7067 NN denotes DNA
T5005 7068-7070 IN denotes by
T5006 7071-7076 VB denotes using
T5007 7077-7083 NN denotes FuGENE
T5008 7084-7086 NN denotes HD
T5009 7087-7088 -LRB- denotes (
T5010 7088-7093 NNP denotes Roche
T5011 7094-7104 NNP denotes Diagnostic
T5012 7105-7109 NNP denotes GmbH
T5013 7109-7110 -COMMA- denotes ,
T5014 7111-7119 NNP denotes Mannheim
T5015 7119-7120 -COMMA- denotes ,
T5016 7121-7128 NNP denotes Germany
T5017 7128-7129 -RRB- denotes )
T5018 7129-7130 -COMMA- denotes ,
T5019 7131-7140 VB denotes according
T5020 7141-7143 TO denotes to
T5021 7144-7147 DT denotes the
T5022 7148-7160 NN denotes manufacturer
T5023 7160-7162 POS denotes 's
T5024 7163-7171 NN denotes protocol
T5025 7171-7172 -COLON- denotes ;
T5026 7173-7178 JJ denotes total
T5027 7179-7182 NN denotes DNA
T5028 7183-7190 NN denotes amounts
T5029 7191-7195 VB denotes were
T5030 7196-7205 VB denotes equalized
T5031 7206-7208 IN denotes by
T5032 7209-7221 NN denotes transfection
T5033 7222-7224 IN denotes of
T5034 7225-7232 NN denotes pRc/CMV
T5035 7233-7238 NN denotes empty
T5036 7239-7245 NN denotes vector
T5037 7246-7247 -LRB- denotes (
T5038 7247-7257 NN denotes Invitrogen
T5039 7257-7258 -COMMA- denotes ,
T5040 7259-7267 NNP denotes Carlsbad
T5041 7267-7268 -COMMA- denotes ,
T5042 7269-7271 NNP denotes CA
T5043 7271-7272 -COMMA- denotes ,
T5044 7273-7276 NNP denotes USA
T5045 7276-7277 -RRB- denotes )
T5046 7279-7282 IN denotes For
T5047 7283-7300 NN denotes pulse-stimulation
T5048 7300-7301 -COMMA- denotes ,
T5049 7302-7306 NN denotes HeLa
T5050 7307-7312 NN denotes cells
T5051 7313-7317 VB denotes were
T5052 7318-7325 VB denotes treated
T5053 7326-7330 IN denotes with
T5054 7331-7338 NN denotes phorbol
T5055 7339-7351 NN denotes 12-myristate
T5056 7352-7362 NN denotes 13-acetate
T5057 7363-7364 -LRB- denotes (
T5058 7364-7367 NN denotes PMA
T5059 7367-7368 -COLON- denotes ;
T5060 7369-7382 JJ denotes Sigma-Aldrich
T5061 7382-7383 -COMMA- denotes ,
T5062 7384-7386 NNP denotes St
T5063 7387-7392 NNP denotes Louis
T5064 7392-7393 -COMMA- denotes ,
T5065 7394-7396 NN denotes MO
T5066 7396-7397 -COMMA- denotes ,
T5067 7398-7401 NNP denotes USA
T5068 7401-7402 -RRB- denotes )
T5069 7403-7404 -LRB- denotes (
T5070 7404-7412 NN denotes 20 ng/ml
T5071 7412-7413 -RRB- denotes )
T5072 7414-7417 IN denotes for
T5073 7418-7423 NN denotes 5 min
T5074 7423-7424 -COMMA- denotes ,
T5075 7425-7427 CC denotes or
T5076 7428-7433 NN denotes tumor
T5077 7434-7442 NN denotes necrosis
T5078 7443-7451 NN denotes factor-α
T5079 7452-7453 -LRB- denotes (
T5080 7453-7458 NN denotes TNF-α
T5081 7458-7459 -COLON- denotes ;
T5082 7460-7473 JJ denotes Sigma-Aldrich
T5083 7473-7474 -RRB- denotes )
T5084 7475-7476 -LRB- denotes (
T5085 7476-7484 NN denotes 20 ng/ml
T5086 7484-7485 -RRB- denotes )
T5087 7486-7489 IN denotes for
T5088 7490-7496 NN denotes 30 min
T5089 7496-7497 -COMMA- denotes ,
T5090 7498-7504 VB denotes washed
T5091 7505-7510 RB denotes twice
T5092 7511-7513 IN denotes in
T5093 7514-7522 JJ denotes complete
T5094 7523-7530 NN denotes culture
T5095 7531-7537 NN denotes medium
T5096 7538-7541 CC denotes and
T5097 7542-7546 RB denotes then
T5098 7547-7555 VB denotes returned
T5099 7556-7558 TO denotes to
T5100 7559-7566 NN denotes culture
T5101 7568-7571 IN denotes For
T5102 7572-7582 NN denotes luciferase
T5103 7583-7589 NN denotes assays
T5104 7589-7590 -COMMA- denotes ,
T5105 7591-7600 NN denotes pSV-β-Gal
T5106 7601-7604 VB denotes was
T5107 7605-7619 VB denotes co-transfected
T5108 7620-7624 IN denotes with
T5109 7625-7631 NN denotes pκBluc
T5110 7632-7634 TO denotes to
T5111 7635-7642 VB denotes monitor
T5112 7643-7646 DT denotes the
T5113 7647-7659 NN denotes transfection
T5114 7660-7670 NN denotes efficiency
T5115 7672-7688 JJ denotes Forty-eight-hour
T5116 7689-7706 JJ denotes post-transfection
T5117 7706-7707 -COMMA- denotes ,
T5118 7708-7713 NN denotes cells
T5119 7714-7718 VB denotes were
T5120 7719-7724 VB denotes lysed
T5121 7725-7727 IN denotes in
T5122 7728-7733 NN denotes lysis
T5123 7734-7740 NN denotes buffer
T5124 7741-7743 IN denotes of
T5125 7744-7748 NNP denotes Dual
T5126 7749-7754 NNP denotes Light
T5127 7755-7765 NNP denotes Luciferase
T5128 7766-7772 NNP denotes System
T5129 7773-7774 -LRB- denotes (
T5130 7774-7780 NNP denotes Tropix
T5131 7780-7781 -COMMA- denotes ,
T5132 7782-7789 NNP denotes Bedford
T5133 7789-7790 -COMMA- denotes ,
T5134 7791-7793 NNP denotes MA
T5135 7793-7794 -COMMA- denotes ,
T5136 7795-7798 NNP denotes USA
T5137 7798-7799 -RRB- denotes )
T5138 7800-7803 CC denotes and
T5139 7804-7807 DT denotes the
T5140 7808-7818 NN denotes luciferase
T5141 7819-7822 CC denotes and
T5142 7823-7838 NN denotes β-galactosidase
T5143 7839-7849 NN denotes activities
T5144 7850-7854 VB denotes were
T5145 7855-7864 VB denotes evaluated
T5146 7865-7867 IN denotes by
T5147 7868-7873 VB denotes using
T5148 7874-7878 NNP denotes Dual
T5149 7879-7884 NNP denotes Light
T5150 7885-7895 NNP denotes Luciferase
T5151 7896-7902 NNP denotes System
T5152 7903-7904 -LRB- denotes (
T5153 7904-7910 NN denotes Tropix
T5154 7910-7911 -RRB- denotes )
T5155 7912-7914 IN denotes in
T5156 7915-7916 DT denotes a
T5157 7917-7931 NN denotes bioluminometer
T5158 7932-7933 -LRB- denotes (
T5159 7933-7939 NNP denotes Turner
T5160 7940-7949 NNP denotes Biosystem
T5161 7949-7950 -COMMA- denotes ,
T5162 7951-7960 NNP denotes Sunnyvale
T5163 7960-7961 -COMMA- denotes ,
T5164 7962-7964 NNP denotes CA
T5165 7964-7965 -COMMA- denotes ,
T5166 7966-7969 NNP denotes USA
T5167 7969-7970 -RRB- denotes )
T5168 7972-7975 DT denotes The
T5169 7976-7981 NN denotes ratio
T5170 7982-7984 IN denotes of
T5171 7985-7992 NN denotes firefly
T5172 7993-8003 NN denotes luciferase
T5173 8004-8012 NN denotes activity
T5174 8013-8015 TO denotes to
T5175 8016-8031 NN denotes β-galactosidase
T5176 8032-8040 NN denotes activity
T5177 8041-8044 VB denotes was
T5178 8045-8054 VB denotes expressed
T5179 8055-8057 IN denotes as
T5180 8058-8066 JJ denotes relative
T5181 8067-8072 JJ denotes light
T5182 8073-8078 NN denotes units
T5682 8081-8084 NN denotes RNA
T5683 8085-8097 NN denotes interference
T5684 8098-8104 NN denotes Jurkat
T5685 8105-8107 CC denotes or
T5686 8108-8112 NN denotes U937
T5687 8113-8118 NN denotes cells
T5688 8119-8123 VB denotes were
T5689 8124-8135 VB denotes transfected
T5690 8136-8138 IN denotes by
T5691 8139-8154 NN denotes electroporation
T5692 8155-8160 VB denotes using
T5693 8161-8162 DT denotes a
T5694 8163-8170 JJ denotes Bio-Rad
T5695 8171-8180 NN denotes apparatus
T5696 8181-8182 -LRB- denotes (
T5697 8182-8189 NNP denotes Bio-Rad
T5698 8190-8202 NNP denotes Laboratories
T5699 8202-8203 -COMMA- denotes ,
T5700 8204-8212 NNP denotes Hercules
T5701 8212-8213 -COMMA- denotes ,
T5702 8214-8216 NNP denotes CA
T5703 8216-8217 -COMMA- denotes ,
T5704 8218-8221 NNP denotes USA
T5705 8221-8222 -RRB- denotes )
T5706 8224-8231 RB denotes Briefly
T5707 8231-8232 -COMMA- denotes ,
T5708 8233-8241 NN denotes aliquots
T5709 8242-8243 -LRB- denotes (
T5710 8243-8250 CD denotes 5 × 106
T5711 8251-8256 NN denotes cells
T5712 8256-8257 -RRB- denotes )
T5713 8258-8262 VB denotes were
T5714 8263-8272 VB denotes suspended
T5715 8273-8275 IN denotes in
T5716 8276-8282 NN denotes 0.3 ml
T5717 8283-8285 IN denotes of
T5718 8286-8290 NN denotes RPMI
T5719 8291-8295 CD denotes 1640
T5720 8296-8308 VB denotes supplemented
T5721 8309-8313 IN denotes with
T5722 8314-8316 CD denotes 20
T5723 8316-8317 NN denotes %
T5724 8318-8323 JJ denotes fetal
T5725 8324-8328 NN denotes calf
T5726 8329-8334 NN denotes serum
T5727 8335-8338 CC denotes and
T5728 8339-8348 VB denotes subjected
T5729 8349-8351 TO denotes to
T5730 8352-8353 DT denotes a
T5731 8354-8360 JJ denotes double
T5732 8361-8371 JJ denotes electrical
T5733 8372-8377 NN denotes pulse
T5734 8378-8379 -LRB- denotes (
T5735 8379-8385 NN denotes 0.22 V
T5736 8385-8386 -COMMA- denotes ,
T5737 8387-8393 NN denotes 960 µF
T5738 8393-8394 -RRB- denotes )
T5739 8395-8397 IN denotes in
T5740 8398-8401 DT denotes the
T5741 8402-8410 NN denotes presence
T5742 8411-8413 IN denotes of
T5743 8414-8422 VB denotes annealed
T5744 8423-8428 NN denotes siRNA
T5745 8429-8430 -LRB- denotes (
T5746 8430-8438 NN denotes 200 pmol
T5747 8438-8439 -RRB- denotes )
T5748 8439-8440 -COLON- denotes ;
T5749 8441-8455 VB denotes electroporated
T5750 8456-8461 NN denotes cells
T5751 8462-8466 VB denotes were
T5752 8467-8473 VB denotes washed
T5753 8474-8477 CC denotes and
T5754 8478-8486 VB denotes cultured
T5755 8487-8489 IN denotes in
T5756 8490-8498 JJ denotes complete
T5757 8499-8505 NN denotes medium
T5758 8507-8510 NN denotes RNA
T5759 8511-8523 NN denotes interference
T5760 8524-8527 VB denotes was
T5761 8528-8537 VB denotes performed
T5762 8538-8542 IN denotes with
T5763 8542-8543 -COLON- denotes :
T5764 8544-8549 NN denotes siRNA
T5765 8550-8553 NN denotes Tat
T5766 8554-8559 NN denotes sense
T5767 8559-8560 -COMMA- denotes ,
T5768 8561-8582 NN denotes CUGCUUGUACCAAUUGCUAUU
T5769 8583-8586 CC denotes and
T5770 8587-8592 NN denotes siRNA
T5771 8593-8596 NN denotes Tat
T5772 8597-8606 JJ denotes antisense
T5773 8606-8607 -COMMA- denotes ,
T5774 8608-8629 NNP denotes UAGCAAUUGGUACAAGCAGUU
T5775 8629-8630 -COLON- denotes ;
T5776 8631-8636 NN denotes siRNA
T5777 8637-8644 NN denotes control
T5778 8645-8650 NN denotes sense
T5779 8650-8651 -COMMA- denotes ,
T5780 8652-8664 NN denotes CUGCUUGUCACA
T5781 8665-8674 NN denotes AUUGCUAUU
T5782 8675-8678 CC denotes and
T5783 8679-8684 NN denotes siRNA
T5784 8685-8692 NN denotes control
T5785 8693-8702 JJ denotes antisense
T5786 8702-8703 -COMMA- denotes ,
T5787 8704-8725 NNP denotes UAGCAAUUGUGACAAGCAGUU
T5788 8727-8730 NN denotes RNA
T5789 8731-8743 NN denotes interference
T5790 8744-8746 IN denotes of
T5791 8747-8750 NN denotes p65
T5792 8751-8754 CC denotes and
T5793 8755-8760 NN denotes IκB-α
T5794 8761-8764 VB denotes was
T5795 8765-8774 VB denotes performed
T5796 8775-8779 IN denotes with
T5797 8780-8785 NN denotes SMART
T5798 8786-8790 NN denotes pool
T5799 8791-8796 NN denotes siRNA
T5800 8797-8800 NN denotes p65
T5801 8801-8804 CC denotes and
T5802 8805-8810 NN denotes IκB-α
T5803 8811-8812 -LRB- denotes (
T5804 8812-8821 NNP denotes Dharmacon
T5805 8821-8822 -COMMA- denotes ,
T5806 8823-8830 NNP denotes Chicago
T5807 8830-8831 -COMMA- denotes ,
T5808 8832-8834 NNP denotes IL
T5809 8834-8835 -COMMA- denotes ,
T5810 8836-8839 NNP denotes USA
T5811 8839-8840 -RRB- denotes )
T6049 8843-8854 VB denotes Pseudotyped
T6050 8855-8862 NN denotes virions
T6051 8863-8866 CC denotes and
T6052 8867-8873 JJ denotes single
T6053 8874-8879 NN denotes round
T6054 8880-8889 NN denotes infection
T6055 8890-8894 NN denotes 293T
T6056 8895-8900 NN denotes cells
T6057 8901-8902 -LRB- denotes (
T6058 8902-8909 CD denotes 1 × 107
T6059 8909-8910 -RRB- denotes )
T6060 8911-8915 VB denotes were
T6061 8916-8927 VB denotes transfected
T6062 8928-8932 IN denotes with
T6063 8933-8948 NN denotes pNL4-3.Luc.R-E-
T6064 8949-8951 CC denotes or
T6065 8952-8972 NN denotes pNL4-3.FLAG-Tat.R-E-
T6066 8973-8974 -LRB- denotes (
T6067 8974-8979 NN denotes 10 µg
T6068 8979-8980 -RRB- denotes )
T6069 8981-8989 RB denotes together
T6070 8990-8994 IN denotes with
T6071 8995-9000 NN denotes pHXB2
T6072 9001-9004 NN denotes Env
T6073 9005-9006 -LRB- denotes (
T6074 9006-9011 NN denotes 10 µg
T6075 9011-9012 -RRB- denotes )
T6076 9012-9013 -COMMA- denotes ,
T6078 9018-9022 JJ denotes 48-h
T6079 9023-9040 JJ denotes post-transfection
T6080 9041-9045 NN denotes cell
T6081 9046-9057 NN denotes supernatant
T6082 9058-9061 VB denotes was
T6083 9062-9071 VB denotes collected
T6084 9073-9086 JJ denotes Enzyme-linked
T6085 9087-9100 JJ denotes immunosorbent
T6086 9101-9106 NN denotes assay
T6087 9107-9108 -LRB- denotes (
T6088 9108-9113 NN denotes ELISA
T6089 9113-9114 -RRB- denotes )
T6090 9115-9120 VB denotes using
T6091 9121-9129 JJ denotes anti-p24
T6092 9130-9138 NN denotes antibody
T6093 9139-9147 VB denotes measured
T6094 9148-9154 NN denotes virion
T6095 9155-9168 NN denotes concentration
T6096 9170-9175 NN denotes PBMCs
T6097 9175-9176 -COMMA- denotes ,
T6098 9177-9183 NN denotes Jurkat
T6099 9184-9186 CC denotes or
T6100 9187-9191 NN denotes U937
T6101 9192-9197 NN denotes cells
T6102 9198-9199 -LRB- denotes (
T6103 9199-9206 CD denotes 5 × 107
T6104 9206-9207 -RRB- denotes )
T6105 9208-9212 VB denotes were
T6106 9213-9221 VB denotes infected
T6107 9222-9226 IN denotes with
T6108 9227-9231 NN denotes HXB2
T6109 9232-9247 JJ denotes Env-pseudotyped
T6110 9248-9255 NN denotes virions
T6111 9256-9257 -LRB- denotes (
T6112 9257-9263 CD denotes 500 ng
T6113 9264-9266 IN denotes of
T6114 9267-9270 NN denotes p24
T6115 9270-9271 -RRB- denotes )
T6116 9272-9274 IN denotes by
T6117 9275-9288 NN denotes spinoculation
T6118 9288-9289 -COMMA- denotes ,
T6119 9290-9292 IN denotes as
T6120 9293-9303 RB denotes previously
T6121 9304-9313 VB denotes described
T6122 9314-9315 -LRB- denotes (
T6123 9315-9317 CD denotes 50
T6124 9317-9318 -RRB- denotes )
T6718 10933-10935 FW denotes In
T6719 10936-10941 FW denotes vitro
T6720 10942-10953 NN denotes translation
T6721 10954-10962 NN denotes HA-IκB-α
T6722 10962-10963 -COMMA- denotes ,
T6723 10964-10967 NN denotes p65
T6724 10968-10971 CC denotes and
T6725 10972-10975 NN denotes Tat
T6726 10976-10980 VB denotes were
T6727 10981-10990 VB denotes expressed
T6728 10991-10996 IN denotes under
T6729 10997-11000 DT denotes the
T6730 11001-11003 NN denotes T7
T6731 11004-11012 NN denotes promoter
T6732 11013-11016 CC denotes and
T6733 11017-11019 FW denotes in
T6734 11020-11025 FW denotes vitro
T6735 11026-11036 VB denotes translated
T6736 11037-11042 VB denotes using
T6737 11043-11046 DT denotes the
T6738 11047-11050 NN denotes TnT
T6739 11051-11056 JJ denotes quick
T6740 11057-11064 VB denotes coupled
T6741 11065-11090 NN denotes transcription/translation
T6742 11091-11097 NN denotes system
T6743 11098-11099 -LRB- denotes (
T6744 11099-11106 NN denotes Promega
T6745 11106-11107 -RRB- denotes )
T6746 11107-11108 -COMMA- denotes ,
T6747 11109-11111 IN denotes as
T6748 11112-11122 RB denotes previously
T6749 11123-11131 VB denotes reported
T6750 11132-11133 -LRB- denotes (
T6751 11133-11135 CD denotes 50
T6752 11135-11136 -RRB- denotes )
T6753 11138-11145 NN denotes Details
T6754 11146-11149 VB denotes are
T6755 11150-11159 VB denotes described
T6756 11160-11162 IN denotes in
T6757 11163-11176 NNP denotes Supplementary
T6758 11177-11181 NNP denotes Data
T6882 11184-11203 NN denotes Immunoprecipitation
T6883 11204-11209 NN denotes assay
T6884 11210-11213 CC denotes and
T6885 11214-11222 NN denotes GST-pull
T6886 11223-11227 RP denotes down
T6887 11228-11247 NN denotes Immunoprecipitation
T6888 11247-11248 -COMMA- denotes ,
T6889 11249-11257 NNP denotes GST-pull
T6890 11258-11262 IN denotes down
T6891 11262-11263 -COMMA- denotes ,
T6892 11264-11267 CC denotes and
T6893 11268-11278 NN denotes production
T6894 11279-11281 IN denotes of
T7016 11417-11426 JJ denotes Real-time
T7017 11427-11430 NN denotes PCR
T7018 11431-11436 JJ denotes Total
T7019 11437-11440 NN denotes RNA
T7020 11441-11444 VB denotes was
T7021 11445-11454 VB denotes extracted
T7022 11455-11459 IN denotes from
T7023 11460-11465 NN denotes cells
T7024 11466-11468 IN denotes by
T7025 11469-11474 VB denotes using
T7026 11475-11478 DT denotes the
T7027 11479-11485 NN denotes TRIzol
T7028 11486-11493 NN denotes reagent
T7029 11494-11495 -LRB- denotes (
T7030 11495-11505 NN denotes Invitrogen
T7031 11505-11506 -RRB- denotes )
T7032 11506-11507 -COLON- denotes ;
T7033 11508-11511 NN denotes RNA
T7034 11512-11520 NN denotes aliquots
T7035 11521-11522 -LRB- denotes (
T7036 11522-11528 NN denotes 200 ng
T7037 11528-11529 -RRB- denotes )
T7038 11530-11534 VB denotes were
T7039 11535-11542 JJ denotes reverse
T7040 11543-11554 VB denotes transcribed
T7041 11555-11560 VB denotes using
T7042 11561-11567 NNP denotes Random
T7043 11568-11575 NNP denotes Examers
T7044 11576-11577 -LRB- denotes (
T7045 11577-11582 NNP denotes Roche
T7046 11582-11583 -RRB- denotes )
T7047 11584-11587 CC denotes and
T7048 11588-11599 NN denotes Superscript
T7049 11600-11603 CD denotes III
T7050 11604-11611 JJ denotes Reverse
T7051 11612-11625 NN denotes Transcriptase
T7052 11626-11627 -LRB- denotes (
T7053 11627-11637 NN denotes Invitrogen
T7054 11637-11638 -RRB- denotes )
T7055 11638-11639 -COMMA- denotes ,
T7056 11640-11649 VB denotes according
T7057 11650-11652 TO denotes to
T7058 11653-11656 DT denotes the
T7059 11657-11669 NN denotes manufacturer
T7060 11669-11671 POS denotes 's
T7061 11672-11680 NN denotes protocol
T7062 11682-11691 JJ denotes Real-time
T7063 11692-11695 NN denotes PCR
T7064 11696-11699 VB denotes was
T7065 11700-11709 VB denotes performed
T7066 11710-11714 IN denotes with
T7067 11715-11718 DT denotes the
T7068 11719-11721 NN denotes iQ
T7069 11722-11727 NNP denotes Green
T7070 11728-11733 NNP denotes Super
T7071 11734-11737 NN denotes mix
T7072 11738-11739 -LRB- denotes (
T7073 11739-11746 NNP denotes Bio-Rad
T7074 11747-11759 NNP denotes Laboratories
T7075 11759-11760 -RRB- denotes )
T7076 11761-11764 CC denotes and
T7077 11765-11772 VB denotes carried
T7078 11773-11776 RP denotes out
T7079 11777-11781 IN denotes with
T7080 11782-11785 DT denotes the
T7081 11786-11793 NN denotes iCycler
T7082 11794-11796 NN denotes iQ
T7083 11797-11806 JJ denotes Real-Time
T7084 11807-11816 NN denotes detection
T7085 11817-11823 NN denotes system
T7086 11824-11825 -LRB- denotes (
T7087 11825-11832 NNP denotes Bio-Rad
T7088 11833-11845 NNP denotes Laboratories
T7089 11845-11846 -RRB- denotes )
T7090 11847-11852 IN denotes under
T7091 11853-11856 DT denotes the
T7092 11857-11866 JJ denotes following
T7093 11867-11877 NN denotes conditions
T7094 11877-11878 -COLON- denotes :
T7095 11879-11883 NN denotes 95°C
T7096 11883-11884 -COMMA- denotes ,
T7097 11885-11890 NN denotes 1 min
T7098 11890-11891 -COLON- denotes ;
T7099 11892-11893 -LRB- denotes (
T7100 11893-11897 NN denotes 94°C
T7101 11897-11898 -COMMA- denotes ,
T7102 11899-11903 NN denotes 10 s
T7103 11903-11904 -COLON- denotes ;
T7104 11905-11909 NN denotes 60°C
T7105 11909-11910 -COMMA- denotes ,
T7106 11911-11915 NN denotes 30 s
T7107 11915-11916 -RRB- denotes )
T7108 11917-11920 CD denotes ×40
T7109 11922-11929 NN denotes Primers
T7110 11930-11933 IN denotes for
T7111 11934-11937 NN denotes Tat
T7112 11938-11941 CC denotes and
T7113 11942-11948 NN denotes MIP-1α
T7114 11949-11952 VB denotes are
T7115 11953-11959 VB denotes listed
T7116 11960-11962 IN denotes in
T7117 11963-11976 NNP denotes Supplementary
T7118 11977-11982 NNP denotes Data.
T7119 11983-11992 NNP denotes Real-time
T7120 11993-11996 NN denotes PCR
T7121 11997-11999 IN denotes of
T7122 12000-12004 NN denotes CSF3
T7123 12004-12005 -COMMA- denotes ,
T7124 12006-12009 NN denotes LTA
T7125 12009-12010 -COMMA- denotes ,
T7126 12011-12017 NN denotes NFKBIA
T7127 12017-12018 -COMMA- denotes ,
T7128 12019-12023 NN denotes TLR2
T7129 12023-12024 -COMMA- denotes ,
T7130 12025-12030 NN denotes GAPDH
T7131 12031-12034 CC denotes and
T7132 12035-12039 NN denotes ACTB
T7133 12040-12043 VB denotes was
T7134 12044-12053 VB denotes performed
T7135 12054-12059 VB denotes using
T7136 12060-12063 DT denotes the
T7137 12064-12067 NN denotes RT2
T7138 12068-12076 NN denotes profiler
T7139 12077-12080 NN denotes PCR
T7140 12081-12092 JJ denotes Array-Human
T7141 12093-12098 NN denotes NF-κB
T7142 12099-12108 NN denotes signaling
T7143 12109-12116 NN denotes pathway
T7144 12117-12118 -LRB- denotes (
T7145 12118-12124 NNP denotes QIAGEN
T7146 12125-12133 NNP denotes Sciences
T7147 12133-12134 -COMMA- denotes ,
T7148 12135-12137 NNP denotes MD
T7149 12137-12138 -COMMA- denotes ,
T7150 12139-12142 NNP denotes USA
T7151 12142-12143 -RRB- denotes )
T7152 12145-12154 NN denotes Reactions
T7153 12155-12159 VB denotes were
T7154 12160-12167 VB denotes carried
T7155 12168-12171 RP denotes out
T7156 12172-12174 IN denotes in
T7157 12175-12185 NN denotes triplicate
T7158 12185-12186 -COMMA- denotes ,
T7159 12187-12190 CC denotes and
T7160 12191-12195 NN denotes gene
T7161 12196-12206 NN denotes expression
T7162 12207-12213 NN denotes levels
T7163 12214-12218 VB denotes were
T7164 12219-12229 VB denotes calculated
T7165 12230-12238 JJ denotes relative
T7166 12239-12241 TO denotes to
T7167 12242-12247 NN denotes GAPDH
T7168 12248-12252 NN denotes mRNA
T7169 12253-12259 NN denotes levels
T7170 12260-12262 IN denotes as
T7171 12263-12273 JJ denotes endogenous
T7172 12274-12281 NN denotes control
T7173 12283-12291 JJ denotes Relative
T7174 12292-12302 NN denotes expression
T7175 12303-12306 VB denotes was
T7176 12307-12317 VB denotes calculated
T7177 12318-12320 IN denotes as
T7178 12321-12322 CD denotes 2
T7179 12322-12323 -LRB- denotes (
T7180 12323-12325 NN denotes Ct
T7181 12326-12330 NN denotes gene
T7182 12331-12336 IN denotes under
T7183 12337-12355 NN denotes investigation − Ct
T7184 12356-12361 NN denotes GAPDH
T7185 12361-12362 -RRB- denotes )
T8159 14748-14759 JJ denotes Statistical
T8160 14760-14768 NN denotes analysis
T8161 14769-14780 JJ denotes Statistical
T8162 14781-14789 NN denotes analysis
T8163 14790-14793 VB denotes was
T8164 14794-14803 VB denotes performed
T8165 14804-14806 IN denotes by
T8166 14807-14815 JJ denotes two-tail
T8167 14816-14824 JJ denotes unpaired
T8168 14825-14832 NN denotes Student
T8169 14832-14834 POS denotes 's
T8170 14835-14841 NN denotes t-test
T8171 14843-14847 NN denotes Data
T8172 14848-14852 VB denotes were
T8173 14853-14861 VB denotes reported
T8174 14862-14864 IN denotes as
T8175 14865-14875 NN denotes means ± SE
T8176 14877-14888 NN denotes Differences
T8177 14889-14896 IN denotes between
T8178 14897-14900 DT denotes the
T8179 14901-14906 NN denotes means
T8180 14907-14911 VB denotes were
T8181 14912-14922 VB denotes considered
T8182 14923-14925 IN denotes as
T8183 14926-14939 RB denotes statistically
T8184 14940-14951 JJ denotes significant
T8185 14952-14954 IN denotes at
T8186 14955-14958 DT denotes the
T8187 14959-14961 CD denotes 95
T8188 14961-14962 NN denotes %
T8189 14963-14968 NN denotes level
T8190 14969-14970 -LRB- denotes (
T8191 14970-14972 NN denotes P 
T8192 14972-14973 SYM denotes <
T8193 14973-14978 CD denotes  0.05
T8194 14978-14979 -RRB- denotes )
T8554 14991-14994 NN denotes Tat
T8555 14995-15003 VB denotes enhances
T8556 15004-15007 DT denotes the
T8557 15008-15013 NN denotes NF-κB
T8558 15014-15022 NN denotes activity
T8559 15023-15025 IN denotes by
T8560 15026-15035 VB denotes hijacking
T8561 15036-15041 NN denotes IκB-α
T8562 15042-15045 CC denotes and
T8563 15046-15056 VB denotes inhibiting
T8564 15057-15060 DT denotes the
T8565 15061-15076 JJ denotes post-activation
T8566 15077-15081 NN denotes turn
T8567 15082-15085 RP denotes off
T8568 15086-15088 IN denotes of
T8569 15089-15094 NN denotes NF-κB
T8570 15095-15097 PRP denotes We
T8571 15098-15106 VB denotes analysed
T8572 15107-15110 DT denotes the
T8573 15111-15118 NN denotes kinetic
T8574 15119-15121 IN denotes of
T8575 15122-15127 NN denotes NF-κB
T8576 15128-15138 NN denotes activation
T8577 15139-15141 IN denotes in
T8578 15142-15148 JJ denotes single
T8579 15149-15154 JJ denotes round
T8580 15155-15160 NN denotes HIV-1
T8581 15161-15170 NN denotes infection
T8582 15171-15173 IN denotes by
T8583 15174-15184 VB denotes modulating
T8584 15185-15188 DT denotes the
T8585 15189-15199 NN denotes expression
T8586 15200-15202 IN denotes of
T8587 15203-15206 NN denotes Tat
T8588 15207-15211 IN denotes with
T8589 15212-15215 NN denotes RNA
T8590 15216-15228 NN denotes interference
T8591 15230-15236 NN denotes Jurkat
T8592 15237-15242 NN denotes cells
T8593 15243-15247 VB denotes were
T8594 15248-15259 VB denotes transfected
T8595 15260-15264 IN denotes with
T8596 15265-15270 NN denotes siRNA
T8597 15271-15274 NN denotes Tat
T8598 15274-15275 -COMMA- denotes ,
T8599 15276-15281 NN denotes siRNA
T8600 15282-15289 NN denotes control
T8601 15289-15290 -COMMA- denotes ,
T8602 15291-15293 CC denotes or
T8603 15294-15298 VB denotes left
T8604 15299-15312 JJ denotes untransfected
T8605 15312-15313 -COMMA- denotes ,
T8606 15314-15317 CC denotes and
T8607 15318-15322 NN denotes 24 h
T8608 15323-15328 JJ denotes later
T8609 15329-15334 NN denotes cells
T8610 15335-15339 VB denotes were
T8611 15340-15348 VB denotes infected
T8612 15349-15353 IN denotes with
T8613 15354-15358 NN denotes HXB2
T8614 15359-15374 JJ denotes Env-pseudotyped
T8615 15375-15389 NN denotes NL4-3.Luc.R−E−
T8616 15390-15397 NN denotes virions
T8617 15399-15401 IN denotes By
T8618 15402-15418 JJ denotes cytofluorimetric
T8619 15419-15427 NN denotes analysis
T8620 15427-15428 -COMMA- denotes ,
T8621 15429-15432 CD denotes ∼40
T8622 15432-15433 NN denotes %
T8623 15434-15436 IN denotes of
T8624 15437-15442 NN denotes cells
T8625 15443-15446 VB denotes was
T8626 15447-15464 JJ denotes siRNA-transfected
T8627 15465-15468 CC denotes and
T8628 15469-15483 JJ denotes HIV-1-infected
T8629 15484-15486 IN denotes at
T8630 15487-15491 JJ denotes 12-h
T8631 15492-15506 JJ denotes post-infection
T8632 15507-15508 -LRB- denotes (
T8633 15508-15521 JJ denotes Supplementary
T8634 15522-15528 NN denotes Figure
T8635 15529-15531 NN denotes S1
T8636 15531-15532 -RRB- denotes )
T8637 15534-15537 DT denotes The
T8638 15538-15548 NN denotes expression
T8639 15549-15551 IN denotes of
T8640 15552-15555 NN denotes Tat
T8641 15556-15559 VB denotes was
T8642 15560-15568 VB denotes detected
T8643 15569-15571 IN denotes at
T8644 15572-15575 JJ denotes 1-h
T8645 15576-15590 JJ denotes post-infection
T8646 15591-15594 CC denotes and
T8647 15595-15608 RB denotes progressively
T8648 15609-15618 VB denotes increased
T8649 15619-15621 RB denotes up
T8650 15622-15624 TO denotes to
T8651 15625-15629 VB denotes 12 h
T8652 15630-15632 IN denotes in
T8653 15633-15646 JJ denotes untransfected
T8654 15647-15650 CC denotes and
T8655 15651-15656 NN denotes siRNA
T8656 15657-15676 JJ denotes control-transfected
T8657 15677-15682 NN denotes cells
T8658 15682-15683 -COMMA- denotes ,
T8659 15684-15689 IN denotes while
T8660 15690-15692 PRP denotes it
T8661 15693-15696 VB denotes was
T8662 15697-15703 RB denotes barely
T8663 15704-15712 VB denotes detected
T8664 15713-15715 IN denotes in
T8665 15716-15721 NN denotes siRNA
T8666 15722-15737 JJ denotes Tat-transfected
T8667 15738-15743 NN denotes cells
T8668 15744-15745 -LRB- denotes (
T8669 15745-15751 NN denotes Figure
T8670 15752-15754 NN denotes 1A
T8671 15754-15755 -RRB- denotes )
T8672 15757-15760 DT denotes The
T8673 15761-15774 JJ denotes LTR-dependent
T8674 15775-15785 NN denotes luciferase
T8675 15786-15796 NN denotes expression
T8676 15797-15800 VB denotes was
T8677 15801-15805 RB denotes also
T8678 15806-15819 RB denotes progressively
T8679 15820-15827 VB denotes induced
T8680 15828-15830 IN denotes at
T8681 15831-15833 CD denotes 1-
T8682 15834-15836 TO denotes to
T8683 15837-15841 JJ denotes 12-h
T8684 15842-15856 NN denotes post-infection
T8685 15857-15859 IN denotes in
T8686 15860-15873 JJ denotes untransfected
T8687 15874-15877 CC denotes and
T8688 15878-15883 NN denotes siRNA
T8689 15884-15903 JJ denotes control-transfected
T8690 15904-15909 NN denotes cells
T8691 15909-15910 -COMMA- denotes ,
T8692 15911-15916 IN denotes while
T8693 15917-15919 PRP denotes it
T8694 15920-15923 VB denotes was
T8695 15924-15930 RB denotes barely
T8696 15931-15939 VB denotes observed
T8697 15940-15942 IN denotes in
T8698 15943-15948 NN denotes siRNA
T8699 15949-15964 JJ denotes Tat-transfected
T8700 15965-15970 NN denotes cells
T8701 15970-15971 -COMMA- denotes ,
T8702 15972-15974 IN denotes as
T8703 15975-15983 VB denotes expected
T8704 15984-15987 IN denotes for
T8705 15988-15991 DT denotes the
T8706 15992-16005 JJ denotes Tat-dependent
T8707 16006-16021 NN denotes transactivation
T8708 16022-16024 IN denotes of
T8709 16025-16028 DT denotes the
T8710 16029-16034 NN denotes HIV-1
T8711 16035-16038 NN denotes LTR
T8712 16039-16040 -LRB- denotes (
T8713 16040-16046 NN denotes Figure
T8714 16047-16049 NN denotes 1A
T8715 16049-16050 -RRB- denotes )
T8716 17245-17248 DT denotes The
T8717 17249-17260 JJ denotes progressive
T8718 17261-17269 NN denotes increase
T8719 17270-17272 IN denotes in
T8720 17273-17278 NN denotes NF-κB
T8721 17279-17287 NN denotes activity
T8722 17287-17288 -COMMA- denotes ,
T8723 17289-17291 IN denotes as
T8724 17292-17300 VB denotes measured
T8725 17301-17303 IN denotes by
T8726 17304-17311 NN denotes p65–p50
T8727 17312-17319 NN denotes binding
T8728 17320-17322 TO denotes to
T8729 17323-17325 DT denotes an
T8730 17326-17331 NN denotes NF-κB
T8731 17332-17341 NN denotes consensus
T8732 17342-17357 NN denotes oligonucleotide
T8733 17358-17359 -LRB- denotes (
T8734 17359-17365 NN denotes Figure
T8735 17366-17368 NN denotes 1B
T8736 17368-17369 -RRB- denotes )
T8737 17370-17373 CC denotes and
T8738 17374-17381 JJ denotes nuclear
T8739 17382-17385 NN denotes p65
T8740 17386-17387 -LRB- denotes (
T8741 17387-17393 NN denotes Figure
T8742 17394-17396 NN denotes 1C
T8743 17396-17397 -COMMA- denotes ,
T8744 17398-17405 NN denotes nucleus
T8745 17405-17406 -RRB- denotes )
T8746 17406-17407 -COMMA- denotes ,
T8747 17408-17411 VB denotes was
T8748 17412-17420 VB denotes observed
T8749 17421-17423 IN denotes at
T8750 17424-17426 CD denotes 1-
T8751 17427-17429 TO denotes to
T8752 17430-17433 JJ denotes 3-h
T8753 17434-17448 NN denotes post-infection
T8754 17449-17451 IN denotes in
T8755 17452-17456 CC denotes both
T8756 17457-17469 JJ denotes Tat-positive
T8757 17470-17471 -LRB- denotes (
T8758 17471-17473 DT denotes no
T8759 17474-17479 NN denotes siRNA
T8760 17480-17482 CC denotes or
T8761 17483-17488 NN denotes siRNA
T8762 17489-17496 NN denotes control
T8763 17496-17497 -RRB- denotes )
T8764 17498-17501 CC denotes and
T8765 17502-17514 JJ denotes Tat-negative
T8766 17515-17516 -LRB- denotes (
T8767 17516-17521 NN denotes siRNA
T8768 17522-17525 NN denotes Tat
T8769 17525-17526 -RRB- denotes )
T8770 17527-17532 NN denotes cells
T8771 17532-17533 -COLON- denotes ;
T8772 17534-17541 RB denotes however
T8773 17541-17542 -COMMA- denotes ,
T8774 17543-17545 IN denotes at
T8775 17546-17550 JJ denotes 12-h
T8776 17551-17565 NN denotes post-infection
T8777 17565-17566 -COMMA- denotes ,
T8778 17567-17570 DT denotes the
T8779 17571-17574 NN denotes p65
T8780 17575-17578 NN denotes DNA
T8781 17579-17586 NN denotes binding
T8782 17587-17590 CC denotes and
T8783 17591-17598 JJ denotes nuclear
T8784 17599-17602 NN denotes p65
T8785 17603-17612 VB denotes persisted
T8786 17613-17621 VB denotes elevated
T8787 17622-17624 IN denotes in
T8788 17625-17633 NN denotes presence
T8789 17634-17636 IN denotes of
T8790 17637-17640 NN denotes Tat
T8791 17641-17642 -LRB- denotes (
T8792 17642-17644 DT denotes no
T8793 17645-17650 NN denotes siRNA
T8794 17651-17654 CC denotes and
T8795 17655-17660 NN denotes siRNA
T8796 17661-17668 NN denotes control
T8797 17668-17669 -RRB- denotes )
T8798 17669-17670 -COMMA- denotes ,
T8799 17671-17676 IN denotes while
T8800 17677-17681 PRP denotes they
T8801 17682-17689 VB denotes dropped
T8802 17690-17692 IN denotes in
T8803 17693-17700 NN denotes absence
T8804 17701-17703 IN denotes of
T8805 17704-17707 NN denotes Tat
T8806 17708-17709 -LRB- denotes (
T8807 17709-17714 NN denotes siRNA
T8808 17715-17718 NN denotes Tat
T8809 17718-17719 -RRB- denotes )
T8810 17720-17721 -LRB- denotes (
T8811 17721-17727 NN denotes Figure
T8812 17728-17730 NN denotes 1B
T8813 17731-17734 CC denotes and
T8814 17735-17736 NN denotes C
T8815 17736-17737 -RRB- denotes )
T8816 17739-17744 NN denotes IκB-α
T8817 17745-17748 VB denotes was
T8818 17749-17757 VB denotes degraded
T8819 17758-17760 IN denotes in
T8820 17761-17764 DT denotes the
T8821 17765-17772 NN denotes cytosol
T8822 17773-17779 IN denotes within
T8823 17780-17783 JJ denotes 3-h
T8824 17784-17798 JJ denotes post-infection
T8825 17799-17802 CC denotes and
T8826 17803-17805 FW denotes de
T8827 17806-17810 FW denotes novo
T8828 17811-17822 VB denotes synthesized
T8829 17823-17825 IN denotes at
T8830 17826-17829 NN denotes 6 h
T8831 17830-17834 IN denotes with
T8832 17835-17839 JJ denotes full
T8833 17840-17853 NN denotes replenishment
T8834 17854-17856 IN denotes at
T8835 17857-17861 JJ denotes 12-h
T8836 17862-17876 NN denotes post-infection
T8837 17877-17879 IN denotes in
T8838 17880-17884 CC denotes both
T8839 17885-17897 JJ denotes Tat-positive
T8840 17898-17901 CC denotes and
T8841 17902-17914 JJ denotes Tat-negative
T8842 17915-17920 NN denotes cells
T8843 17921-17922 -LRB- denotes (
T8844 17922-17928 NN denotes Figure
T8845 17929-17931 NN denotes 1C
T8846 17931-17932 -COMMA- denotes ,
T8847 17933-17940 NN denotes cytosol
T8848 17940-17941 -RRB- denotes )
T8849 17943-17955 RB denotes Consistently
T8850 17955-17956 -COMMA- denotes ,
T8851 17957-17960 DT denotes the
T8852 17961-17964 NN denotes IKK
T8853 17965-17973 NN denotes activity
T8854 17974-17977 VB denotes was
T8855 17978-17985 VB denotes induced
T8856 17986-17988 IN denotes at
T8857 17989-17992 JJ denotes 1-h
T8858 17993-18007 NN denotes post-infection
T8859 18007-18008 -COMMA- denotes ,
T8860 18009-18012 CC denotes and
T8861 18013-18022 VB denotes decreased
T8862 18023-18025 IN denotes at
T8863 18026-18029 JJ denotes 3-h
T8864 18030-18044 JJ denotes post-infection
T8865 18045-18058 RB denotes independently
T8866 18059-18061 IN denotes of
T8867 18062-18065 DT denotes the
T8868 18066-18074 NN denotes presence
T8869 18075-18077 IN denotes of
T8870 18078-18081 NN denotes Tat
T8871 18082-18083 -LRB- denotes (
T8872 18083-18089 NN denotes Figure
T8873 18090-18092 NN denotes 1D
T8874 18092-18093 -RRB- denotes )
T8875 18095-18102 JJ denotes Similar
T8876 18103-18111 NN denotes kinetics
T8877 18112-18114 IN denotes of
T8878 18115-18120 NN denotes NF-κB
T8879 18121-18129 NN denotes activity
T8880 18129-18130 -COMMA- denotes ,
T8881 18131-18134 NN denotes IKK
T8882 18135-18145 NN denotes activation
T8883 18146-18149 CC denotes and
T8884 18150-18155 NN denotes IκB-α
T8885 18156-18180 NN denotes degradation/re-synthesis
T8886 18181-18185 VB denotes were
T8887 18186-18194 VB denotes observed
T8888 18195-18197 IN denotes in
T8889 18198-18210 JJ denotes single-round
T8890 18211-18216 NN denotes HIV-1
T8891 18217-18226 NN denotes infection
T8892 18227-18229 IN denotes of
T8893 18230-18235 NN denotes PBMCs
T8894 18236-18241 VB denotes using
T8895 18242-18243 DT denotes a
T8896 18244-18252 NN denotes cocktail
T8897 18253-18255 IN denotes of
T8898 18256-18270 NN denotes Azidothymidine
T8899 18271-18272 -LRB- denotes (
T8900 18272-18275 NN denotes AZT
T8901 18275-18276 -RRB- denotes )
T8902 18277-18280 CC denotes and
T8903 18281-18291 NN denotes Lamivudine
T8904 18292-18293 -LRB- denotes (
T8905 18293-18296 NN denotes 3TC
T8906 18296-18297 -RRB- denotes )
T8907 18298-18300 IN denotes as
T8908 18301-18308 JJ denotes reverse
T8909 18309-18322 NN denotes transcriptase
T8910 18323-18333 NN denotes inhibitors
T8911 18334-18335 -LRB- denotes (
T8912 18335-18348 JJ denotes Supplementary
T8913 18349-18355 NNP denotes Figure
T8914 18356-18358 NN denotes S2
T8915 18358-18359 -RRB- denotes )
T8916 18361-18366 DT denotes These
T8917 18367-18374 NN denotes results
T8918 18375-18384 VB denotes indicated
T8919 18385-18389 IN denotes that
T8920 18390-18392 IN denotes in
T8921 18393-18405 JJ denotes single-round
T8922 18406-18411 NN denotes HIV-1
T8923 18412-18421 NN denotes infection
T8924 18422-18425 DT denotes the
T8925 18426-18431 NN denotes NF-κB
T8926 18432-18442 NN denotes activation
T8927 18443-18452 RB denotes initially
T8928 18453-18463 VB denotes correlated
T8929 18464-18468 IN denotes with
T8930 18469-18472 DT denotes the
T8931 18473-18476 NN denotes IKK
T8932 18477-18487 NN denotes activation
T8933 18488-18491 CC denotes and
T8934 18492-18497 JJ denotes IκB-α
T8935 18498-18509 NN denotes degradation
T8936 18510-18523 RB denotes independently
T8937 18524-18526 IN denotes of
T8938 18527-18530 DT denotes the
T8939 18531-18539 NN denotes presence
T8940 18540-18542 IN denotes of
T8941 18543-18546 NN denotes Tat
T8942 18546-18547 -COMMA- denotes ,
T8943 18548-18551 CC denotes and
T8944 18552-18554 PRP denotes it
T8945 18555-18558 VB denotes was
T8946 18559-18563 VB denotes kept
T8947 18564-18572 VB denotes elevated
T8948 18573-18575 IN denotes in
T8949 18576-18584 NN denotes presence
T8950 18585-18587 IN denotes of
T8951 18588-18591 NN denotes Tat
T8952 18592-18601 VB denotes following
T8953 18602-18605 DT denotes the
T8954 18606-18611 NN denotes decay
T8955 18612-18614 IN denotes of
T8956 18615-18618 DT denotes the
T8957 18619-18622 NN denotes IKK
T8958 18623-18631 NN denotes activity
T8959 18632-18635 CC denotes and
T8960 18636-18639 JJ denotes new
T8961 18640-18649 NN denotes synthesis
T8962 18650-18652 IN denotes of
T8963 18653-18658 NN denotes IκB-α
T8964 18660-18664 RB denotes Next
T8965 18664-18665 -COMMA- denotes ,
T8966 18666-18668 PRP denotes we
T8967 18669-18675 VB denotes tested
T8968 18676-18679 DT denotes the
T8969 18680-18686 JJ denotes single
T8970 18687-18693 NN denotes action
T8971 18694-18696 IN denotes of
T8972 18697-18700 NN denotes Tat
T8973 18701-18703 IN denotes on
T8974 18704-18707 DT denotes the
T8975 18708-18715 NN denotes kinetic
T8976 18716-18718 IN denotes of
T8977 18719-18724 NN denotes NF-κB
T8978 18725-18733 NN denotes activity
T8979 18734-18741 VB denotes induced
T8980 18742-18744 IN denotes by
T8981 18745-18748 NN denotes PMA
T8982 18750-18752 TO denotes To
T8983 18753-18757 DT denotes this
T8984 18758-18761 NN denotes end
T8985 18761-18762 -COMMA- denotes ,
T8986 18763-18767 NN denotes HeLa
T8987 18768-18773 NN denotes cells
T8988 18774-18778 VB denotes were
T8989 18779-18790 VB denotes transfected
T8990 18791-18795 IN denotes with
T8991 18796-18808 NN denotes p3x-FLAG-Tat
T8992 18808-18809 -COMMA- denotes ,
T8993 18810-18812 CC denotes or
T8994 18813-18818 JJ denotes empty
T8995 18819-18825 NN denotes vector
T8996 18825-18826 -COMMA- denotes ,
T8997 18827-18837 VB denotes stimulated
T8998 18838-18842 IN denotes with
T8999 18843-18846 NN denotes PMA
T9000 18847-18850 IN denotes for
T9001 18851-18856 NN denotes 5 min
T9002 18856-18857 -COMMA- denotes ,
T9003 18858-18861 CC denotes and
T9004 18862-18873 RB denotes extensively
T9005 18874-18880 VB denotes washed
T9006 18881-18883 TO denotes to
T9007 18884-18889 VB denotes avoid
T9008 18890-18893 DT denotes the
T9009 18894-18905 JJ denotes oscillatory
T9010 18906-18913 NN denotes kinetic
T9011 18914-18916 IN denotes of
T9012 18917-18922 NN denotes NF-κB
T9013 18923-18933 NN denotes activation
T9014 18934-18935 -LRB- denotes (
T9015 18935-18940 CD denotes 17,18
T9016 18940-18941 -RRB- denotes )
T9017 18943-18945 IN denotes In
T9018 18946-18959 JJ denotes un-stimulated
T9019 18960-18965 NN denotes cells
T9020 18965-18966 -COMMA- denotes ,
T9021 18967-18970 DT denotes the
T9022 18971-18974 NN denotes p65
T9023 18975-18978 NN denotes DNA
T9024 18979-18986 NN denotes binding
T9025 18987-18988 -LRB- denotes (
T9026 18988-18994 NN denotes Figure
T9027 18995-18997 NN denotes 2A
T9028 18997-18998 -RRB- denotes )
T9029 18999-19002 CC denotes and
T9030 19003-19010 JJ denotes nuclear
T9031 19011-19014 NN denotes p65
T9032 19015-19016 -LRB- denotes (
T9033 19016-19022 NN denotes Figure
T9034 19023-19025 NN denotes 2B
T9035 19025-19026 -COMMA- denotes ,
T9036 19027-19034 NN denotes nucleus
T9037 19034-19035 -RRB- denotes )
T9038 19036-19040 VB denotes were
T9039 19041-19049 RB denotes slightly
T9040 19050-19058 VB denotes enhanced
T9041 19059-19061 IN denotes by
T9042 19062-19065 NN denotes Tat
T9043 19065-19066 -COMMA- denotes ,
T9044 19067-19072 IN denotes while
T9045 19073-19076 DT denotes the
T9046 19077-19082 JJ denotes IκB-α
T9047 19083-19090 NN denotes content
T9048 19091-19094 VB denotes was
T9049 19095-19098 RB denotes not
T9050 19099-19112 RB denotes significantly
T9051 19113-19121 VB denotes affected
T9052 19122-19123 -LRB- denotes (
T9053 19123-19129 NN denotes Figure
T9054 19130-19132 NN denotes 2B
T9055 19132-19133 -COMMA- denotes ,
T9056 19134-19141 NN denotes cytosol
T9057 19141-19142 -RRB- denotes )
T9058 19144-19153 JJ denotes Transient
T9059 19154-19165 NN denotes stimulation
T9060 19166-19170 IN denotes with
T9061 19171-19174 NN denotes PMA
T9062 19175-19184 VB denotes increased
T9063 19185-19188 DT denotes the
T9064 19189-19194 NN denotes NF-κB
T9065 19195-19198 NN denotes DNA
T9066 19199-19206 NN denotes binding
T9067 19207-19215 NN denotes activity
T9068 19216-19219 CC denotes and
T9069 19220-19227 JJ denotes nuclear
T9070 19228-19231 NN denotes p65
T9071 19232-19234 IN denotes at
T9072 19235-19240 NN denotes 5 min
T9073 19241-19248 VB denotes peaking
T9074 19249-19251 IN denotes at
T9075 19252-19262 NN denotes 60–120 min
T9076 19263-19276 RB denotes independently
T9077 19277-19279 IN denotes of
T9078 19280-19283 DT denotes the
T9079 19284-19292 NN denotes presence
T9080 19293-19295 IN denotes of
T9081 19296-19299 NN denotes Tat
T9082 19300-19301 -LRB- denotes (
T9083 19301-19307 NN denotes Figure
T9084 19308-19310 NN denotes 2A
T9085 19311-19314 CC denotes and
T9086 19315-19316 NN denotes B
T9087 19316-19317 -RRB- denotes )
T9088 19317-19318 -COLON- denotes ;
T9089 19319-19326 RB denotes however
T9090 19326-19327 -COMMA- denotes ,
T9091 19328-19333 IN denotes while
T9092 19334-19337 DT denotes the
T9093 19338-19341 NN denotes p65
T9094 19342-19345 NN denotes DNA
T9095 19346-19353 NN denotes binding
T9096 19354-19357 CC denotes and
T9097 19358-19365 JJ denotes nuclear
T9098 19366-19369 NN denotes p65
T9099 19370-19379 VB denotes persisted
T9100 19380-19388 VB denotes elevated
T9101 19389-19391 IN denotes at
T9102 19392-19399 JJ denotes 240-min
T9103 19400-19414 JJ denotes post-treatment
T9104 19415-19417 IN denotes in
T9105 19418-19430 JJ denotes Tat-positive
T9106 19431-19436 NN denotes cells
T9107 19436-19437 -COMMA- denotes ,
T9108 19438-19442 PRP denotes they
T9109 19443-19450 VB denotes dropped
T9110 19451-19453 IN denotes in
T9111 19454-19466 JJ denotes Tat-negative
T9112 19467-19472 NN denotes cells
T9113 19473-19474 -LRB- denotes (
T9114 19474-19480 NN denotes Figure
T9115 19481-19483 NN denotes 2A
T9116 19484-19487 CC denotes and
T9117 19488-19489 NN denotes B
T9118 19489-19490 -RRB- denotes )
T9119 19492-19494 IN denotes In
T9120 19495-19503 NN denotes addition
T9121 19503-19504 -COMMA- denotes ,
T9122 19505-19508 NN denotes Tat
T9123 19509-19514 VB denotes bound
T9124 19515-19517 TO denotes to
T9125 19518-19521 DT denotes the
T9126 19522-19527 NN denotes NF-κB
T9127 19528-19543 NN denotes oligonucleotide
T9128 19544-19546 IN denotes in
T9129 19547-19560 JJ denotes un-stimulated
T9130 19561-19566 NN denotes cells
T9131 19567-19570 CC denotes and
T9132 19571-19574 PRP-DOLLAR- denotes its
T9133 19575-19582 NN denotes binding
T9134 19583-19592 VB denotes increased
T9135 19593-19602 VB denotes following
T9136 19603-19606 NN denotes PMA
T9137 19607-19618 NN denotes stimulation
T9138 19619-19620 -LRB- denotes (
T9139 19620-19626 NN denotes Figure
T9140 19627-19629 NN denotes 2A
T9141 19629-19630 -RRB- denotes )
T9142 19630-19631 -COMMA- denotes ,
T9143 19632-19642 VB denotes suggesting
T9144 19643-19647 IN denotes that
T9145 19648-19651 DT denotes the
T9146 19652-19657 JJ denotes viral
T9147 19658-19665 NN denotes protein
T9148 19666-19669 VB denotes was
T9149 19670-19671 DT denotes a
T9150 19672-19681 NN denotes component
T9151 19682-19684 IN denotes of
T9152 19685-19688 DT denotes the
T9153 19689-19694 NN denotes NF-κB
T9154 19695-19702 NN denotes complex
T9155 19703-19708 VB denotes bound
T9156 19709-19711 TO denotes to
T9157 19712-19715 NN denotes DNA
T9158 19717-19728 NN denotes Degradation
T9159 19729-19731 IN denotes of
T9160 19732-19737 NN denotes IκB-α
T9161 19738-19741 VB denotes was
T9162 19742-19755 RB denotes progressively
T9163 19756-19763 VB denotes induced
T9164 19764-19766 IN denotes at
T9165 19767-19775 NN denotes 5–30 min
T9166 19775-19776 -COMMA- denotes ,
T9167 19777-19785 VB denotes followed
T9168 19786-19788 IN denotes by
T9169 19789-19791 FW denotes de
T9170 19792-19796 FW denotes novo
T9171 19797-19806 NN denotes synthesis
T9172 19807-19809 IN denotes at
T9173 19810-19816 NN denotes 60 min
T9174 19817-19821 IN denotes with
T9175 19822-19826 JJ denotes full
T9176 19827-19840 NN denotes replenishment
T9177 19841-19843 IN denotes at
T9178 19844-19851 NN denotes 240 min
T9179 19852-19854 IN denotes in
T9180 19855-19859 CC denotes both
T9181 19860-19872 JJ denotes Tat-positive
T9182 19873-19876 CC denotes and
T9183 19877-19885 JJ denotes negative
T9184 19886-19891 NN denotes cells
T9185 19892-19893 -LRB- denotes (
T9186 19893-19899 NN denotes Figure
T9187 19900-19902 NN denotes 2B
T9188 19902-19903 -COMMA- denotes ,
T9189 19904-19911 NN denotes cytosol
T9190 19911-19912 -RRB- denotes )
T9191 19914-19926 RB denotes Consistently
T9192 19926-19927 -COMMA- denotes ,
T9193 19928-19931 DT denotes the
T9194 19932-19935 NN denotes IKK
T9195 19936-19946 NN denotes activation
T9196 19947-19954 VB denotes started
T9197 19955-19957 IN denotes at
T9198 19958-19963 NN denotes 5 min
T9199 19963-19964 -COMMA- denotes ,
T9200 19965-19968 CC denotes and
T9201 19969-19975 VB denotes turned
T9202 19976-19979 RP denotes off
T9203 19980-19982 IN denotes at
T9204 19983-19989 CD denotes 30 min
T9205 19990-20003 RB denotes independently
T9206 20004-20006 IN denotes of
T9207 20007-20010 DT denotes the
T9208 20011-20019 NN denotes presence
T9209 20020-20022 IN denotes of
T9210 20023-20026 NN denotes Tat
T9211 20027-20028 -LRB- denotes (
T9212 20028-20034 NN denotes Figure
T9213 20035-20037 NN denotes 2C
T9214 20037-20038 -RRB- denotes )
T9215 20040-20045 DT denotes These
T9216 20046-20053 NN denotes results
T9217 20054-20063 VB denotes indicated
T9218 20064-20068 IN denotes that
T9219 20069-20072 NN denotes Tat
T9220 20073-20081 VB denotes enhanced
T9221 20082-20085 DT denotes the
T9222 20086-20091 NN denotes NF-κB
T9223 20092-20100 NN denotes activity
T9224 20101-20103 IN denotes in
T9225 20104-20117 JJ denotes un-stimulated
T9226 20118-20121 CC denotes and
T9227 20122-20136 JJ denotes PMA-stimulated
T9228 20137-20142 NN denotes cells
T9229 20143-20150 IN denotes without
T9230 20151-20160 VB denotes affecting
T9231 20161-20164 DT denotes the
T9232 20165-20168 NN denotes IKK
T9233 20169-20177 NN denotes activity
T9234 20178-20181 CC denotes and
T9235 20182-20187 JJ denotes IκB-α
T9236 20188-20195 NN denotes content
T9237 21813-21815 IN denotes As
T9238 21816-21818 PRP denotes we
T9239 21819-21829 RB denotes previously
T9240 21830-21835 VB denotes found
T9241 21836-21840 IN denotes that
T9242 21841-21844 NN denotes Tat
T9243 21845-21850 VB denotes binds
T9244 21851-21853 TO denotes to
T9245 21854-21857 DT denotes the
T9246 21858-21863 JJ denotes sixth
T9247 21864-21871 NN denotes ankyrin
T9248 21872-21874 IN denotes of
T9249 21875-21880 NN denotes IκB-α
T9250 21881-21882 -LRB- denotes (
T9251 21882-21887 CD denotes 50,51
T9252 21887-21888 -RRB- denotes )
T9253 21888-21889 -COMMA- denotes ,
T9254 21890-21892 PRP denotes we
T9255 21893-21899 VB denotes tested
T9256 21900-21907 IN denotes whether
T9257 21908-21911 NN denotes Tat
T9258 21912-21924 VB denotes counteracted
T9259 21925-21928 DT denotes the
T9260 21929-21939 NN denotes generation
T9261 21940-21942 IN denotes of
T9262 21943-21946 DT denotes the
T9263 21947-21958 NN denotes IκB-α/NF-κB
T9264 21959-21966 NN denotes complex
T9265 21968-21970 TO denotes To
T9266 21971-21975 DT denotes this
T9267 21976-21979 NN denotes end
T9268 21979-21980 -COMMA- denotes ,
T9269 21981-21984 DT denotes the
T9270 21985-21996 NN denotes association
T9271 21997-21999 IN denotes of
T9272 22000-22005 NN denotes IκB-α
T9273 22006-22010 IN denotes with
T9274 22011-22014 NN denotes p65
T9275 22015-22018 VB denotes was
T9276 22019-22027 VB denotes analysed
T9277 22028-22030 FW denotes in
T9278 22031-22035 FW denotes vivo
T9279 22036-22038 IN denotes at
T9280 22039-22040 CD denotes 0
T9281 22041-22044 CC denotes and
T9282 22045-22052 NN denotes 240 min
T9283 22053-22058 IN denotes after
T9284 22059-22070 JJ denotes short-pulse
T9285 22071-22074 NN denotes PMA
T9286 22074-22075 -COMMA- denotes ,
T9287 22076-22081 WDT denotes which
T9288 22082-22094 VB denotes corresponded
T9289 22095-22097 TO denotes to
T9290 22098-22101 DT denotes the
T9291 22102-22106 NN denotes time
T9292 22107-22109 IN denotes of
T9293 22110-22123 JJ denotes un-stimulated
T9294 22124-22133 NN denotes condition
T9295 22134-22137 CC denotes and
T9296 22138-22153 JJ denotes post-activation
T9297 22154-22156 FW denotes de
T9298 22157-22161 FW denotes novo
T9299 22162-22171 NN denotes synthesis
T9300 22172-22174 IN denotes of
T9301 22175-22180 NN denotes IκB-α
T9302 22180-22181 -COMMA- denotes ,
T9303 22182-22194 RB denotes respectively
T9304 22196-22217 NN denotes Coimmunoprecipitation
T9305 22218-22220 IN denotes of
T9306 22221-22226 NN denotes IκB-α
T9307 22227-22231 IN denotes with
T9308 22232-22235 NN denotes p65
T9309 22236-22239 VB denotes was
T9310 22240-22248 VB denotes detected
T9311 22249-22251 IN denotes at
T9312 22252-22254 CD denotes 0-
T9313 22255-22258 CC denotes and
T9314 22259-22266 NN denotes 240-min
T9315 22267-22281 JJ denotes post-treatment
T9316 22282-22284 IN denotes in
T9317 22285-22297 JJ denotes Tat-negative
T9318 22298-22303 NN denotes cells
T9319 22304-22305 -LRB- denotes (
T9320 22305-22311 NN denotes Figure
T9321 22312-22314 NN denotes 2D
T9322 22314-22315 -COMMA- denotes ,
T9323 22316-22321 NN denotes lanes
T9324 22322-22323 CD denotes 1
T9325 22324-22327 CC denotes and
T9326 22328-22329 CD denotes 3
T9327 22329-22330 -RRB- denotes )
T9328 22330-22331 -COMMA- denotes ,
T9329 22332-22335 CC denotes and
T9330 22336-22339 VB denotes was
T9331 22340-22346 VB denotes halved
T9332 22347-22349 IN denotes in
T9333 22350-22362 JJ denotes Tat-positive
T9334 22363-22368 NN denotes cells
T9335 22368-22369 -COMMA- denotes ,
T9336 22370-22375 WRB denotes where
T9337 22376-22379 NN denotes Tat
T9338 22380-22400 VB denotes coimmunoprecipitated
T9339 22401-22405 IN denotes with
T9340 22406-22411 NN denotes IκB-α
T9341 22412-22413 -LRB- denotes (
T9342 22413-22419 NN denotes Figure
T9343 22420-22422 NN denotes 2D
T9344 22422-22423 -COMMA- denotes ,
T9345 22424-22429 NN denotes lanes
T9346 22430-22431 CD denotes 2
T9347 22432-22435 CC denotes and
T9348 22436-22437 CD denotes 4
T9349 22437-22438 -RRB- denotes )
T9350 22438-22439 -COMMA- denotes ,
T9351 22440-22450 VB denotes indicating
T9352 22451-22455 IN denotes that
T9353 22456-22459 NN denotes Tat
T9354 22460-22468 VB denotes competed
T9355 22469-22472 DT denotes the
T9356 22473-22478 JJ denotes IκB-α
T9357 22479-22486 NN denotes binding
T9358 22487-22489 TO denotes to
T9359 22490-22493 NN denotes p65
T11613 22496-22499 NN denotes Tat
T11614 22500-22511 VB denotes counteracts
T11615 22512-22515 DT denotes the
T11616 22516-22521 JJ denotes IκB-α
T11617 22522-22532 NN denotes inhibition
T11618 22533-22535 IN denotes of
T11619 22536-22539 NN denotes p65
T11620 22540-22542 IN denotes by
T11621 22543-22552 VB denotes competing
T11622 22553-22556 DT denotes the
T11623 22557-22566 NN denotes repressor
T11624 22567-22574 NN denotes binding
T11625 22575-22577 PRP denotes We
T11626 22578-22585 RB denotes further
T11627 22586-22598 VB denotes investigated
T11628 22599-22602 DT denotes the
T11629 22603-22611 JJ denotes physical
T11630 22612-22623 NN denotes interaction
T11631 22624-22626 IN denotes of
T11632 22627-22630 NN denotes Tat
T11633 22631-22635 IN denotes with
T11634 22636-22641 NN denotes IκB-α
T11635 22642-22647 VB denotes using
T11636 22648-22650 FW denotes in
T11637 22651-22656 FW denotes vitro
T11638 22657-22667 VB denotes translated
T11639 22668-22676 NN denotes proteins
T11640 22677-22679 IN denotes in
T11641 22680-22701 NN denotes coimmunoprecipitation
T11642 22702-22708 NN denotes assays
T11643 22710-22713 IN denotes For
T11644 22714-22721 VB denotes mapping
T11645 22722-22725 DT denotes the
T11646 22726-22737 NN denotes interaction
T11647 22738-22745 NN denotes domains
T11648 22745-22746 -COMMA- denotes ,
T11649 22747-22749 PRP denotes we
T11650 22750-22754 VB denotes used
T11651 22755-22758 DT denotes the
T11652 22759-22768 VB denotes following
T11653 22769-22772 NN denotes Tat
T11654 22773-22780 NN denotes mutants
T11655 22780-22781 -COLON- denotes :
T11656 22782-22785 NN denotes Tat
T11657 22786-22787 NNP denotes T
T11658 22787-22788 -COMMA- denotes ,
T11659 22788-22789 NN denotes N
T11660 22789-22790 -LRB- denotes (
T11661 22790-22795 CD denotes 23,24
T11662 22795-22796 -RRB- denotes )
T11663 22796-22797 NN denotes A
T11664 22797-22798 -COMMA- denotes ,
T11665 22799-22802 NN denotes Tat
T11666 22803-22804 NN denotes C
T11667 22804-22805 -LRB- denotes (
T11668 22805-22813 CD denotes 22,25,27
T11669 22813-22814 -RRB- denotes )
T11670 22814-22815 NN denotes A
T11671 22815-22816 -COMMA- denotes ,
T11672 22817-22820 NN denotes Tat
T11673 22821-22822 NN denotes K
T11674 22822-22823 -LRB- denotes (
T11675 22823-22828 CD denotes 50,51
T11676 22828-22829 -RRB- denotes )
T11677 22829-22830 NN denotes A
T11678 22831-22834 CC denotes and
T11679 22835-22838 NN denotes Tat
T11680 22839-22840 NN denotes R
T11681 22840-22841 -LRB- denotes (
T11682 22841-22846 CD denotes 49–57
T11683 22846-22847 -RRB- denotes )
T11684 22847-22848 NN denotes A
T11685 22849-22850 -LRB- denotes (
T11686 22850-22856 NN denotes Figure
T11687 22857-22859 NN denotes 3A
T11688 22859-22860 -RRB- denotes )
T11689 22862-22867 NN denotes IκB-α
T11690 22868-22888 VB denotes coimmunoprecipitated
T11691 22889-22893 IN denotes with
T11692 22894-22897 DT denotes all
T11693 22898-22901 NN denotes Tat
T11694 22902-22910 NN denotes proteins
T11695 22910-22911 -COMMA- denotes ,
T11696 22912-22918 IN denotes except
T11697 22919-22922 NN denotes Tat
T11698 22923-22924 NN denotes R
T11699 22924-22925 -LRB- denotes (
T11700 22925-22930 CD denotes 49–57
T11701 22930-22931 -RRB- denotes )
T11702 22931-22932 NN denotes A
T11703 22933-22934 -LRB- denotes (
T11704 22934-22940 NN denotes Figure
T11705 22941-22943 NN denotes 3B
T11706 22943-22944 -RRB- denotes )
T11707 22946-22951 DT denotes These
T11708 22952-22959 NN denotes results
T11709 22960-22969 VB denotes indicated
T11710 22970-22974 IN denotes that
T11711 22975-22978 DT denotes the
T11712 22979-22992 JJ denotes arginine-rich
T11713 22993-22999 NN denotes domain
T11714 23000-23002 IN denotes of
T11715 23003-23006 NN denotes Tat
T11716 23007-23010 VB denotes was
T11717 23011-23019 VB denotes involved
T11718 23020-23022 IN denotes in
T11719 23023-23026 DT denotes the
T11720 23027-23034 NN denotes binding
T11721 23035-23037 TO denotes to
T11722 23038-23043 NN denotes IκB-α
T11723 23043-23044 -COMMA- denotes ,
T11724 23045-23050 WDT denotes which
T11725 23051-23054 VB denotes was
T11726 23055-23065 JJ denotes consistent
T11727 23066-23070 IN denotes with
T11728 23071-23079 JJ denotes previous
T11729 23080-23092 NN denotes observations
T11730 23093-23094 -LRB- denotes (
T11731 23094-23099 CD denotes 50,51
T11732 23099-23100 -RRB- denotes )
T11733 23102-23110 RB denotes Moreover
T11734 23110-23111 -COMMA- denotes ,
T11735 23112-23115 NN denotes Tat
T11736 23116-23127 VB denotes associating
T11737 23128-23132 IN denotes with
T11738 23133-23138 NN denotes IκB-α
T11739 23139-23147 VB denotes competed
T11740 23148-23151 DT denotes the
T11741 23152-23159 NN denotes binding
T11742 23160-23162 IN denotes of
T11743 23163-23168 NN denotes IκB-α
T11744 23169-23171 TO denotes to
T11745 23172-23175 NN denotes p65
T11746 23176-23178 IN denotes in
T11747 23179-23180 DT denotes a
T11748 23181-23195 JJ denotes dose-dependent
T11749 23196-23202 NN denotes manner
T11750 23203-23204 -LRB- denotes (
T11751 23204-23210 NN denotes Figure
T11752 23211-23213 NN denotes 3C
T11753 23213-23214 -COMMA- denotes ,
T11754 23215-23220 NN denotes lanes
T11755 23221-23224 CD denotes 3–5
T11756 23224-23225 -RRB- denotes )
T11757 23225-23226 -COMMA- denotes ,
T11758 23227-23232 IN denotes while
T11759 23233-23236 NN denotes Tat
T11760 23237-23238 NN denotes R
T11761 23238-23239 -LRB- denotes (
T11762 23239-23244 CD denotes 49–57
T11763 23244-23245 -RRB- denotes )
T11764 23245-23246 NN denotes A
T11765 23246-23247 -COMMA- denotes ,
T11766 23248-23253 WDT denotes which
T11767 23254-23260 VB denotes lacked
T11768 23261-23264 DT denotes the
T11769 23265-23272 VB denotes binding
T11770 23273-23277 NN denotes site
T11771 23278-23281 IN denotes for
T11772 23282-23287 NN denotes IκB-α
T11773 23287-23288 -COMMA- denotes ,
T11774 23289-23292 VB denotes did
T11775 23293-23296 RB denotes not
T11776 23297-23306 VB denotes associate
T11777 23307-23311 IN denotes with
T11778 23312-23317 NN denotes IκB-α
T11779 23318-23321 CC denotes and
T11780 23322-23325 VB denotes did
T11781 23326-23329 RB denotes not
T11782 23330-23337 VB denotes compete
T11783 23338-23341 DT denotes the
T11784 23342-23349 NN denotes binding
T11785 23350-23352 IN denotes of
T11786 23353-23358 NN denotes IκB-α
T11787 23359-23361 TO denotes to
T11788 23362-23365 NN denotes p65
T11789 23366-23367 -LRB- denotes (
T11790 23367-23373 NN denotes Figure
T11791 23374-23376 NN denotes 3C
T11792 23376-23377 -COMMA- denotes ,
T11793 23378-23383 NN denotes lanes
T11794 23384-23387 CD denotes 6–8
T11795 23387-23388 -RRB- denotes )
T11796 25484-25488 RB denotes Next
T11797 25488-25489 -COMMA- denotes ,
T11798 25490-25492 PRP denotes we
T11799 25493-25502 VB denotes evaluated
T11800 25503-25510 IN denotes whether
T11801 25511-25514 NN denotes Tat
T11802 25515-25527 VB denotes counteracted
T11803 25528-25531 DT denotes the
T11804 25532-25546 JJ denotes IκB-α-mediated
T11805 25547-25557 NN denotes inhibition
T11806 25558-25560 IN denotes of
T11807 25561-25564 NN denotes p65
T11808 25565-25572 NN denotes binding
T11809 25573-25575 TO denotes to
T11810 25576-25579 NN denotes DNA
T11811 25580-25582 IN denotes by
T11812 25583-25593 VB denotes incubating
T11813 25594-25596 FW denotes in
T11814 25597-25602 FW denotes vitro
T11815 25603-25613 VB denotes translated
T11816 25614-25617 NN denotes p65
T11817 25618-25621 CC denotes and
T11818 25622-25627 NN denotes IκB-α
T11819 25628-25636 NN denotes proteins
T11820 25637-25641 IN denotes with
T11821 25642-25645 DT denotes the
T11822 25646-25651 NN denotes NF-κB
T11823 25652-25657 NN denotes probe
T11824 25658-25660 IN denotes in
T11825 25661-25669 NN denotes presence
T11826 25670-25672 CC denotes or
T11827 25673-25680 NN denotes absence
T11828 25681-25683 IN denotes of
T11829 25684-25687 NN denotes Tat
T11830 25688-25696 VB denotes followed
T11831 25697-25699 IN denotes by
T11832 25700-25704 NN denotes EMSA
T11833 25706-25709 DT denotes The
T11834 25710-25713 NN denotes p65
T11835 25714-25717 NN denotes DNA
T11836 25718-25725 NN denotes binding
T11837 25726-25734 NN denotes activity
T11838 25735-25738 VB denotes was
T11839 25739-25748 VB denotes inhibited
T11840 25749-25751 IN denotes by
T11841 25752-25757 NN denotes IκB-α
T11842 25758-25761 CC denotes and
T11843 25762-25770 VB denotes restored
T11844 25771-25773 IN denotes in
T11845 25774-25775 DT denotes a
T11846 25776-25790 JJ denotes dose-dependent
T11847 25791-25797 NN denotes manner
T11848 25798-25800 IN denotes by
T11849 25801-25810 JJ denotes wild-type
T11850 25811-25814 NN denotes Tat
T11851 25814-25815 -COMMA- denotes ,
T11852 25816-25819 CC denotes and
T11853 25820-25823 RB denotes not
T11854 25824-25826 IN denotes by
T11855 25827-25830 NN denotes Tat
T11856 25831-25832 NN denotes R
T11857 25832-25833 -LRB- denotes (
T11858 25833-25838 CD denotes 49–57
T11859 25838-25839 -RRB- denotes )
T11860 25840-25841 -LRB- denotes (
T11861 25841-25847 NN denotes Figure
T11862 25848-25850 NN denotes 3D
T11863 25850-25851 -RRB- denotes )
T11864 25853-25860 RB denotes Further
T11865 25860-25861 -COMMA- denotes ,
T11866 25862-25864 PRP denotes we
T11867 25865-25873 VB denotes analysed
T11868 25874-25877 DT denotes the
T11869 25878-25881 NN denotes Tat
T11870 25882-25888 NN denotes effect
T11871 25889-25891 IN denotes on
T11872 25892-25895 DT denotes the
T11873 25896-25901 JJ denotes IκB-α
T11874 25902-25912 NN denotes repression
T11875 25913-25915 IN denotes of
T11876 25916-25919 NN denotes p65
T11877 25920-25935 JJ denotes transcriptional
T11878 25936-25944 NN denotes activity
T11879 25945-25947 IN denotes by
T11880 25948-25960 VB denotes transfecting
T11881 25961-25977 NN denotes p50−/−p65−/−MEFs
T11882 25978-25982 IN denotes with
T11883 25983-25986 DT denotes the
T11884 25987-25996 NN denotes NF-κB-Luc
T11885 25997-26005 NN denotes reporter
T11886 26006-26014 RB denotes together
T11887 26015-26019 IN denotes with
T11888 26020-26030 NN denotes expression
T11889 26031-26038 NN denotes vectors
T11890 26039-26041 IN denotes of
T11891 26042-26045 NN denotes p65
T11892 26046-26049 CC denotes and
T11893 26050-26055 NN denotes IκB-α
T11894 26055-26056 -COMMA- denotes ,
T11895 26057-26059 IN denotes in
T11896 26060-26068 NN denotes presence
T11897 26069-26071 CC denotes or
T11898 26072-26079 NN denotes absence
T11899 26080-26082 IN denotes of
T11900 26083-26087 NNP denotes Tat.
T11901 26088-26093 NNP denotes IκB-α
T11902 26094-26103 VB denotes inhibited
T11903 26104-26107 DT denotes the
T11904 26108-26121 JJ denotes p65-dependent
T11905 26122-26132 NN denotes expression
T11906 26133-26135 IN denotes of
T11907 26136-26139 DT denotes the
T11908 26140-26150 NN denotes luciferase
T11909 26151-26155 NN denotes gene
T11910 26155-26156 -COMMA- denotes ,
T11911 26157-26162 WDT denotes which
T11912 26163-26166 VB denotes was
T11913 26167-26175 VB denotes restored
T11914 26176-26178 IN denotes in
T11915 26179-26180 DT denotes a
T11916 26181-26195 JJ denotes dose-dependent
T11917 26196-26202 NN denotes manner
T11918 26203-26205 IN denotes by
T11919 26206-26215 JJ denotes wild-type
T11920 26216-26219 NN denotes Tat
T11921 26219-26220 -COMMA- denotes ,
T11922 26221-26224 CC denotes and
T11923 26225-26228 RB denotes not
T11924 26229-26231 IN denotes by
T11925 26232-26235 NN denotes Tat
T11926 26236-26237 NN denotes R
T11927 26237-26238 -LRB- denotes (
T11928 26238-26243 CD denotes 49–57
T11929 26243-26244 -RRB- denotes )
T11930 26244-26245 NN denotes A
T11931 26246-26247 -LRB- denotes (
T11932 26247-26253 NN denotes Figure
T11933 26254-26256 NN denotes 3E
T11934 26256-26257 -RRB- denotes )
T11935 26259-26269 RB denotes Altogether
T11936 26270-26275 DT denotes these
T11937 26276-26283 NN denotes results
T11938 26284-26293 VB denotes indicated
T11939 26294-26298 IN denotes that
T11940 26299-26302 NN denotes Tat
T11941 26303-26314 VB denotes counteracts
T11942 26315-26318 DT denotes the
T11943 26319-26324 JJ denotes IκB-α
T11944 26325-26335 NN denotes repression
T11945 26336-26338 IN denotes of
T11946 26339-26342 DT denotes the
T11947 26343-26346 NN denotes p65
T11948 26347-26358 JJ denotes DNA-binding
T11949 26359-26362 CC denotes and
T11950 26363-26378 JJ denotes transcriptional
T11951 26379-26387 NN denotes activity
T11952 26388-26390 IN denotes by
T11953 26391-26402 VB denotes associating
T11954 26403-26407 IN denotes with
T11955 26408-26413 NN denotes IκB-α
T11956 26414-26417 CC denotes and
T11957 26418-26427 VB denotes competing
T11958 26428-26431 DT denotes the
T11959 26432-26441 NN denotes repressor
T11960 26442-26449 NN denotes binding
T11961 26450-26452 TO denotes to
T11962 26453-26456 NN denotes p65
T13335 26459-26462 NN denotes Tat
T13336 26463-26472 VB denotes increases
T13337 26473-26476 DT denotes the
T13338 26477-26480 NN denotes p65
T13339 26481-26489 NN denotes affinity
T13340 26490-26497 NN denotes binding
T13341 26498-26500 TO denotes to
T13342 26501-26504 NN denotes DNA
T13343 26505-26512 IN denotes through
T13344 26513-26524 NN denotes association
T13345 26525-26529 IN denotes with
T13346 26530-26533 NN denotes p65
T13347 26534-26536 PRP denotes We
T13348 26537-26543 VB denotes tested
T13349 26544-26551 IN denotes whether
T13350 26552-26555 NN denotes Tat
T13351 26556-26566 RB denotes physically
T13352 26567-26577 VB denotes interacted
T13353 26578-26582 IN denotes with
T13354 26583-26586 NN denotes p65
T13355 26588-26592 NN denotes HeLa
T13356 26593-26598 NN denotes cells
T13357 26599-26603 VB denotes were
T13358 26604-26615 VB denotes transfected
T13359 26616-26620 IN denotes with
T13360 26621-26624 DT denotes the
T13361 26625-26635 NN denotes expression
T13362 26636-26643 NN denotes vectors
T13363 26644-26646 IN denotes of
T13364 26647-26653 NN denotes HA-p65
T13365 26654-26657 CC denotes and
T13366 26658-26666 NN denotes FLAG-Tat
T13367 26666-26667 -COMMA- denotes ,
T13368 26668-26671 CC denotes and
T13369 26672-26676 NN denotes 24 h
T13370 26677-26682 JJ denotes later
T13371 26683-26686 NN denotes Tat
T13372 26687-26690 VB denotes was
T13373 26691-26709 VB denotes immunoprecipitated
T13374 26710-26714 IN denotes from
T13375 26715-26719 NN denotes cell
T13376 26720-26728 NN denotes extracts
T13377 26730-26733 DT denotes The
T13378 26734-26737 NN denotes p65
T13379 26738-26745 NN denotes protein
T13380 26746-26749 VB denotes was
T13381 26750-26770 VB denotes coimmunoprecipitated
T13382 26771-26775 IN denotes with
T13383 26776-26785 JJ denotes wild-type
T13384 26786-26789 NN denotes Tat
T13385 26790-26792 CC denotes or
T13386 26793-26796 DT denotes the
T13387 26797-26804 NN denotes mutants
T13388 26805-26808 NN denotes Tat
T13389 26809-26810 NN denotes T
T13390 26810-26811 -COMMA- denotes ,
T13391 26811-26812 NN denotes N
T13392 26812-26813 -LRB- denotes (
T13393 26813-26818 CD denotes 23,24
T13394 26818-26819 -RRB- denotes )
T13395 26819-26820 NN denotes A
T13396 26820-26821 -COMMA- denotes ,
T13397 26822-26825 NN denotes Tat
T13398 26826-26827 NN denotes K
T13399 26827-26828 -LRB- denotes (
T13400 26828-26833 CD denotes 50,51
T13401 26833-26834 -RRB- denotes )
T13402 26834-26835 NN denotes A
T13403 26836-26839 CC denotes and
T13404 26840-26843 NN denotes Tat
T13405 26844-26845 NN denotes R
T13406 26845-26846 -LRB- denotes (
T13407 26846-26851 CD denotes 49–57
T13408 26851-26852 -RRB- denotes )
T13409 26852-26853 NN denotes A
T13410 26854-26856 IN denotes at
T13411 26857-26864 JJ denotes similar
T13412 26865-26871 NN denotes levels
T13413 26871-26872 -COMMA- denotes ,
T13414 26873-26878 IN denotes while
T13415 26879-26880 DT denotes a
T13416 26881-26892 JJ denotes significant
T13417 26893-26901 NN denotes decrease
T13418 26902-26904 IN denotes in
T13419 26905-26926 NN denotes coimmunoprecipitation
T13420 26927-26930 VB denotes was
T13421 26931-26939 VB denotes observed
T13422 26940-26943 IN denotes for
T13423 26944-26947 NN denotes Tat
T13424 26948-26949 NN denotes C
T13425 26949-26950 -LRB- denotes (
T13426 26950-26958 CD denotes 22,25,27
T13427 26958-26959 -RRB- denotes )
T13428 26959-26960 NN denotes A
T13429 26961-26962 -LRB- denotes (
T13430 26962-26968 NN denotes Figure
T13431 26969-26971 NN denotes 4A
T13432 26971-26972 -RRB- denotes )
T13433 26974-26986 RB denotes Consistently
T13434 26986-26987 -COMMA- denotes ,
T13435 26988-26996 NNP denotes GST-pull
T13436 26997-27001 IN denotes down
T13437 27002-27004 IN denotes of
T13438 27005-27007 FW denotes in
T13439 27008-27013 FW denotes vitro
T13440 27014-27024 VB denotes translated
T13441 27025-27033 NN denotes proteins
T13442 27034-27040 VB denotes showed
T13443 27041-27044 DT denotes the
T13444 27045-27051 JJ denotes direct
T13445 27052-27059 NN denotes binding
T13446 27060-27062 IN denotes of
T13447 27063-27066 NN denotes p65
T13448 27067-27069 TO denotes to
T13449 27070-27079 JJ denotes wild-type
T13450 27080-27083 NN denotes Tat
T13451 27083-27084 -COMMA- denotes ,
T13452 27085-27087 CC denotes or
T13453 27088-27091 DT denotes the
T13454 27092-27099 NN denotes mutants
T13455 27100-27103 NN denotes Tat
T13456 27104-27105 NN denotes T
T13457 27105-27106 -COMMA- denotes ,
T13458 27106-27107 NN denotes N
T13459 27107-27108 -LRB- denotes (
T13460 27108-27113 CD denotes 23,24
T13461 27113-27114 -RRB- denotes )
T13462 27114-27115 NN denotes A
T13463 27115-27116 -COMMA- denotes ,
T13464 27117-27120 NN denotes Tat
T13465 27121-27122 NN denotes K
T13466 27122-27123 -LRB- denotes (
T13467 27123-27128 CD denotes 50,51
T13468 27128-27129 -RRB- denotes )
T13469 27129-27130 NN denotes A
T13470 27131-27134 CC denotes and
T13471 27135-27138 NN denotes Tat
T13472 27139-27140 NN denotes R
T13473 27140-27141 -LRB- denotes (
T13474 27141-27146 CD denotes 49–57
T13475 27146-27147 -RRB- denotes )
T13476 27147-27148 NN denotes A
T13477 27148-27149 -COMMA- denotes ,
T13478 27150-27153 CC denotes and
T13479 27154-27158 NN denotes lack
T13480 27159-27161 IN denotes of
T13481 27162-27169 VB denotes binding
T13482 27170-27172 TO denotes to
T13483 27173-27176 NN denotes Tat
T13484 27177-27178 NN denotes C
T13485 27178-27179 -LRB- denotes (
T13486 27179-27187 CD denotes 22,25,27
T13487 27187-27188 -RRB- denotes )
T13488 27188-27189 NN denotes A
T13489 27190-27191 -LRB- denotes (
T13490 27191-27197 NN denotes Figure
T13491 27198-27200 NN denotes 4B
T13492 27200-27201 -RRB- denotes )
T13493 27203-27208 DT denotes These
T13494 27209-27216 NN denotes results
T13495 27217-27226 VB denotes indicated
T13496 27227-27231 IN denotes that
T13497 27232-27235 NN denotes Tat
T13498 27236-27246 VB denotes associated
T13499 27247-27251 IN denotes with
T13500 27252-27255 NN denotes p65
T13501 27256-27263 IN denotes through
T13502 27264-27267 DT denotes the
T13503 27268-27281 JJ denotes cysteine-rich
T13504 27282-27288 NN denotes domain
T13505 27289-27292 CC denotes and
T13506 27293-27302 NN denotes ruled-out
T13507 27303-27306 DT denotes the
T13508 27307-27318 NN denotes requirement
T13509 27319-27321 IN denotes of
T13510 27322-27330 VB denotes bridging
T13511 27331-27339 NN denotes proteins
T13512 27340-27342 TO denotes to
T13513 27343-27350 VB denotes mediate
T13514 27351-27355 JJ denotes such
T13515 27356-27367 NN denotes interaction
T13516 29093-29095 TO denotes To
T13517 29096-29104 VB denotes identify
T13518 29105-29108 DT denotes the
T13519 29109-29112 NN denotes p65
T13520 29113-29119 NN denotes domain
T13521 29120-29128 VB denotes required
T13522 29129-29132 IN denotes for
T13523 29133-29140 VB denotes binding
T13524 29141-29143 TO denotes to
T13525 29144-29147 NN denotes Tat
T13526 29147-29148 -COMMA- denotes ,
T13527 29149-29153 NN denotes HeLa
T13528 29154-29159 NN denotes cells
T13529 29160-29164 VB denotes were
T13530 29165-29176 VB denotes transfected
T13531 29177-29181 IN denotes with
T13532 29182-29190 NN denotes FLAG-Tat
T13533 29191-29199 RB denotes together
T13534 29200-29204 IN denotes with
T13535 29205-29211 NN denotes HA-p65
T13536 29212-29219 NN denotes mutants
T13537 29219-29220 -COMMA- denotes ,
T13538 29221-29226 WDT denotes which
T13539 29227-29231 VB denotes were
T13540 29232-29239 VB denotes deleted
T13541 29240-29242 IN denotes of
T13542 29243-29246 DT denotes the
T13543 29247-29262 NN denotes transactivation
T13544 29263-29269 NN denotes domain
T13545 29270-29271 -LRB- denotes [
T13546 29271-29276 NN denotes p65ΔC
T13547 29277-29278 -LRB- denotes (
T13548 29278-29283 CD denotes 1–318
T13549 29283-29284 -RRB- denotes )
T13550 29284-29285 -RRB- denotes ]
T13551 29285-29286 -COMMA- denotes ,
T13552 29287-29289 CC denotes or
T13553 29290-29293 DT denotes the
T13554 29294-29297 NN denotes RHD
T13555 29298-29299 -LRB- denotes [
T13556 29299-29304 NN denotes p65ΔN
T13557 29305-29306 -LRB- denotes (
T13558 29306-29313 CD denotes 122–551
T13559 29313-29314 -RRB- denotes )
T13560 29314-29315 -RRB- denotes ]
T13561 29316-29317 -LRB- denotes (
T13562 29317-29323 NN denotes Figure
T13563 29324-29326 NN denotes 4C
T13564 29326-29327 -RRB- denotes )
T13565 29329-29332 NN denotes Tat
T13566 29333-29353 VB denotes coimmunoprecipitated
T13567 29354-29358 IN denotes with
T13568 29359-29364 NN denotes p65ΔC
T13569 29365-29366 -LRB- denotes (
T13570 29366-29371 CD denotes 1–318
T13571 29371-29372 -RRB- denotes )
T13572 29372-29373 -COMMA- denotes ,
T13573 29374-29377 CC denotes and
T13574 29378-29381 RB denotes not
T13575 29382-29386 IN denotes with
T13576 29387-29392 NN denotes p65ΔN
T13577 29393-29394 -LRB- denotes (
T13578 29394-29401 CD denotes 122–551
T13579 29401-29402 -RRB- denotes )
T13580 29403-29404 -LRB- denotes (
T13581 29404-29410 NN denotes Figure
T13582 29411-29413 NN denotes 4D
T13583 29413-29414 -RRB- denotes )
T13584 29414-29415 -COMMA- denotes ,
T13585 29416-29426 VB denotes indicating
T13586 29427-29431 IN denotes that
T13587 29432-29435 DT denotes the
T13588 29436-29439 NN denotes RHD
T13589 29440-29442 IN denotes of
T13590 29443-29446 NN denotes p65
T13591 29447-29450 VB denotes was
T13592 29451-29459 VB denotes involved
T13593 29460-29462 IN denotes in
T13594 29463-29466 DT denotes the
T13595 29467-29475 JJ denotes physical
T13596 29476-29487 NN denotes interaction
T13597 29488-29492 IN denotes with
T13598 29493-29496 NN denotes Tat
T13599 29498-29500 TO denotes To
T13600 29501-29508 VB denotes address
T13601 29509-29512 DT denotes the
T13602 29513-29519 NN denotes effect
T13603 29520-29522 IN denotes of
T13604 29523-29526 NN denotes Tat
T13605 29527-29529 IN denotes on
T13606 29530-29533 DT denotes the
T13607 29534-29537 NN denotes p65
T13608 29538-29549 JJ denotes DNA-binding
T13609 29550-29558 NN denotes affinity
T13610 29558-29559 -COMMA- denotes ,
T13611 29560-29568 VB denotes purified
T13612 29569-29580 JJ denotes recombinant
T13613 29581-29584 NN denotes p65
T13614 29585-29592 NN denotes protein
T13615 29593-29596 VB denotes was
T13616 29597-29606 VB denotes incubated
T13617 29607-29611 IN denotes with
T13618 29612-29629 NN denotes 32P-labeled-NF-κB
T13619 29630-29645 JJ denotes double-stranded
T13620 29646-29661 NN denotes oligonucleotide
T13621 29662-29664 IN denotes in
T13622 29665-29673 NN denotes presence
T13623 29674-29676 CC denotes or
T13624 29677-29684 NN denotes absence
T13625 29685-29687 IN denotes of
T13626 29688-29697 JJ denotes wild-type
T13627 29698-29701 NN denotes Tat
T13628 29702-29704 CC denotes or
T13629 29705-29708 NN denotes Tat
T13630 29709-29710 NN denotes C
T13631 29710-29711 -LRB- denotes (
T13632 29711-29719 CD denotes 22,25,27
T13633 29719-29720 -RRB- denotes )
T13634 29720-29721 NN denotes A
T13635 29721-29722 -COMMA- denotes ,
T13636 29723-29726 CC denotes and
T13637 29727-29730 NN denotes p65
T13638 29731-29742 NN denotes DNA-binding
T13639 29743-29746 VB denotes was
T13640 29747-29755 VB denotes analysed
T13641 29756-29758 IN denotes by
T13642 29759-29763 NN denotes EMSA
T13643 29765-29772 IN denotes Whereas
T13644 29773-29782 JJ denotes wild-type
T13645 29783-29786 NN denotes Tat
T13646 29787-29800 RB denotes significantly
T13647 29801-29810 VB denotes increased
T13648 29811-29814 DT denotes the
T13649 29815-29822 NN denotes binding
T13650 29823-29825 IN denotes of
T13651 29826-29829 NN denotes p65
T13652 29830-29832 TO denotes to
T13653 29833-29836 NN denotes DNA
T13654 29836-29837 -COMMA- denotes ,
T13655 29838-29841 DT denotes the
T13656 29842-29848 JJ denotes mutant
T13657 29849-29852 NN denotes Tat
T13658 29853-29854 NN denotes C
T13659 29854-29855 -LRB- denotes (
T13660 29855-29863 CD denotes 22,25,27
T13661 29863-29864 -RRB- denotes )
T13662 29864-29865 NN denotes A
T13663 29865-29866 -COMMA- denotes ,
T13664 29867-29874 VB denotes lacking
T13665 29875-29878 DT denotes the
T13666 29879-29886 VB denotes binding
T13667 29887-29891 NN denotes site
T13668 29892-29895 IN denotes for
T13669 29896-29899 NN denotes p65
T13670 29899-29900 -COMMA- denotes ,
T13671 29901-29904 VB denotes was
T13672 29905-29916 JJ denotes ineffective
T13673 29917-29918 -LRB- denotes (
T13674 29918-29924 NN denotes Figure
T13675 29925-29927 NN denotes 4E
T13676 29927-29928 -RRB- denotes )
T13677 29930-29933 DT denotes The
T13678 29934-29937 NN denotes p65
T13679 29938-29945 NN denotes binding
T13680 29946-29948 TO denotes to
T13681 29949-29952 NN denotes DNA
T13682 29953-29956 VB denotes was
T13683 29957-29966 VB denotes evaluated
T13684 29967-29969 IN denotes by
T13685 29970-29981 NN denotes competition
T13686 29982-29986 IN denotes with
T13687 29987-29997 VB denotes increasing
T13688 29998-30005 NN denotes amounts
T13689 30006-30008 IN denotes of
T13690 30009-30013 JJ denotes cold
T13691 30014-30024 NN denotes competitor
T13692 30025-30030 NN denotes NF-κB
T13693 30031-30046 NN denotes oligonucleotide
T13694 30046-30047 -COMMA- denotes ,
T13695 30048-30053 WDT denotes which
T13696 30054-30060 VB denotes showed
T13697 30061-30065 IN denotes that
T13698 30066-30069 NN denotes Tat
T13699 30070-30083 RB denotes significantly
T13700 30084-30092 VB denotes enhanced
T13701 30093-30096 DT denotes the
T13702 30097-30100 NN denotes p65
T13703 30101-30109 NN denotes affinity
T13704 30110-30117 NN denotes binding
T13705 30118-30120 TO denotes to
T13706 30121-30124 NN denotes DNA
T13707 30125-30126 -LRB- denotes (
T13708 30126-30132 NN denotes Figure
T13709 30133-30135 NN denotes 4E
T13710 30136-30139 CC denotes and
T13711 30140-30141 NN denotes F
T13712 30141-30142 -RRB- denotes )
T15237 30145-30148 NN denotes Tat
T15238 30149-30158 VB denotes activates
T15239 30159-30162 DT denotes the
T15240 30163-30176 JJ denotes p65-dependent
T15241 30177-30187 NN denotes expression
T15242 30188-30190 IN denotes of
T15243 30191-30207 JJ denotes NF-κB-responsive
T15244 30208-30213 NN denotes genes
T15245 30213-30214 -COMMA- denotes ,
T15246 30215-30223 VB denotes occupies
T15247 30224-30227 DT denotes the
T15248 30228-30233 NN denotes NF-κB
T15249 30234-30243 NN denotes enhancers
T15250 30244-30247 CC denotes and
T15251 30248-30256 VB denotes promotes
T15252 30257-30260 DT denotes the
T15253 30261-30264 NN denotes p65
T15254 30265-30276 NN denotes recruitment
T15255 30277-30281 IN denotes with
T15256 30282-30287 NN denotes IκB-α
T15257 30288-30300 NN denotes displacement
T15258 30301-30303 PRP denotes We
T15259 30304-30312 VB denotes analysed
T15260 30313-30316 DT denotes the
T15261 30317-30323 NN denotes action
T15262 30324-30326 IN denotes of
T15263 30327-30330 NN denotes Tat
T15264 30331-30333 IN denotes on
T15265 30334-30337 DT denotes the
T15266 30338-30348 NN denotes expression
T15267 30349-30351 IN denotes of
T15268 30352-30368 JJ denotes NF-κB-responsive
T15269 30369-30374 NN denotes genes
T15270 30375-30377 FW denotes in
T15271 30378-30382 FW denotes vivo
T15272 30384-30386 TO denotes To
T15273 30387-30391 DT denotes this
T15274 30392-30395 NN denotes end
T15275 30395-30396 -COMMA- denotes ,
T15276 30397-30401 NN denotes HeLa
T15277 30402-30407 NN denotes cells
T15278 30408-30412 VB denotes were
T15279 30413-30424 VB denotes transfected
T15280 30425-30429 IN denotes with
T15281 30430-30438 NN denotes FLAG-Tat
T15282 30438-30439 -COMMA- denotes ,
T15283 30440-30448 NN denotes FLAG-Tat
T15284 30449-30450 NN denotes C
T15285 30450-30451 -LRB- denotes (
T15286 30451-30459 CD denotes 22,25,27
T15287 30459-30460 -RRB- denotes )
T15288 30460-30461 NN denotes A
T15289 30462-30464 CC denotes or
T15290 30465-30473 NN denotes FLAG-Tat
T15291 30474-30475 NN denotes R
T15292 30475-30476 -LRB- denotes (
T15293 30476-30481 CD denotes 49–57
T15294 30481-30482 -RRB- denotes )
T15295 30482-30483 NN denotes A
T15296 30483-30484 -COMMA- denotes ,
T15297 30485-30488 CC denotes and
T15298 30489-30493 NN denotes 48 h
T15299 30494-30499 RB denotes later
T15300 30500-30503 DT denotes the
T15301 30504-30514 NN denotes expression
T15302 30515-30517 IN denotes of
T15303 30518-30519 DT denotes a
T15304 30520-30526 NN denotes number
T15305 30527-30529 IN denotes of
T15306 30530-30545 JJ denotes NF-κB-dependent
T15307 30546-30551 NN denotes genes
T15308 30552-30555 VB denotes was
T15309 30556-30564 VB denotes analysed
T15310 30565-30567 IN denotes by
T15311 30568-30577 JJ denotes real-time
T15312 30578-30581 NN denotes PCR
T15313 30583-30586 NN denotes Tat
T15314 30587-30600 RB denotes significantly
T15315 30601-30610 VB denotes increased
T15316 30611-30614 DT denotes the
T15317 30615-30625 NN denotes expression
T15318 30626-30628 IN denotes of
T15319 30629-30635 NN denotes MIP-1α
T15320 30635-30636 -COMMA- denotes ,
T15321 30637-30641 NN denotes CSF3
T15322 30641-30642 -COMMA- denotes ,
T15323 30643-30646 NN denotes LTA
T15324 30646-30647 -COMMA- denotes ,
T15325 30648-30654 NN denotes NFKBIA
T15326 30655-30658 CC denotes and
T15327 30659-30663 NN denotes TLR2
T15328 30663-30664 -COMMA- denotes ,
T15329 30665-30670 IN denotes while
T15330 30671-30674 DT denotes the
T15331 30675-30682 NN denotes mutants
T15332 30683-30686 NN denotes Tat
T15333 30687-30688 NN denotes C
T15334 30688-30689 -LRB- denotes (
T15335 30689-30697 CD denotes 22,25,27
T15336 30697-30698 -RRB- denotes )
T15337 30698-30699 NN denotes A
T15338 30700-30703 CC denotes and
T15339 30704-30707 NN denotes Tat
T15340 30708-30709 NN denotes R
T15341 30709-30710 -LRB- denotes (
T15342 30710-30715 CD denotes 49–57
T15343 30715-30716 -RRB- denotes )
T15344 30716-30717 NN denotes A
T15345 30718-30722 VB denotes were
T15346 30723-30734 JJ denotes ineffective
T15347 30735-30736 -LRB- denotes (
T15348 30736-30742 NN denotes Figure
T15349 30743-30747 NN denotes 5A–E
T15350 30747-30748 -RRB- denotes )
T15351 30750-30753 DT denotes The
T15352 30754-30767 JJ denotes Tat-dependent
T15353 30768-30783 NN denotes transactivation
T15354 30784-30786 IN denotes of
T15355 30787-30790 DT denotes the
T15356 30791-30806 JJ denotes NF-κB-dependent
T15357 30807-30812 NN denotes genes
T15358 30813-30816 VB denotes was
T15359 30817-30826 VB denotes abolished
T15360 30827-30831 WRB denotes when
T15361 30832-30837 NN denotes cells
T15362 30838-30842 VB denotes were
T15363 30843-30854 VB denotes transfected
T15364 30855-30859 IN denotes with
T15365 30860-30865 NN denotes siRNA
T15366 30866-30869 NN denotes p65
T15367 30869-30870 -COMMA- denotes ,
T15368 30871-30881 VB denotes indicating
T15369 30882-30886 IN denotes that
T15370 30887-30890 DT denotes the
T15371 30891-30894 NN denotes Tat
T15372 30895-30910 JJ denotes transcriptional
T15373 30911-30921 NN denotes activation
T15374 30922-30925 VB denotes was
T15375 30926-30934 VB denotes mediated
T15376 30935-30937 IN denotes by
T15377 30938-30941 NN denotes p65
T15378 30942-30943 -LRB- denotes (
T15379 30943-30949 NN denotes Figure
T15380 30950-30954 NN denotes 5A–E
T15381 30954-30955 -RRB- denotes )
T15382 30957-30968 RB denotes Differently
T15383 30968-30969 -COMMA- denotes ,
T15384 30970-30973 DT denotes the
T15385 30974-30984 NN denotes expression
T15386 30985-30987 IN denotes of
T15387 30988-30991 DT denotes the
T15388 30992-31009 JJ denotes NF-κB-independent
T15389 31010-31015 NN denotes genes
T15390 31016-31021 NN denotes GAPDH
T15391 31022-31025 CC denotes and
T15392 31026-31030 NN denotes ACTB
T15393 31031-31034 VB denotes was
T15394 31035-31045 JJ denotes unaffected
T15395 31046-31048 IN denotes by
T15396 31049-31058 JJ denotes wild-type
T15397 31059-31062 CC denotes and
T15398 31063-31066 NN denotes Tat
T15399 31067-31074 NN denotes mutants
T15400 31075-31076 -LRB- denotes (
T15401 31076-31082 NN denotes Figure
T15402 31083-31085 NN denotes 5F
T15403 31086-31089 CC denotes and
T15404 31090-31091 NN denotes G
T15405 31091-31092 -RRB- denotes )
T15406 31094-31099 DT denotes These
T15407 31100-31107 NN denotes results
T15408 31108-31112 VB denotes were
T15409 31113-31123 JJ denotes consistent
T15410 31124-31128 IN denotes with
T15411 31129-31132 DT denotes the
T15412 31133-31144 NN denotes requirement
T15413 31145-31147 IN denotes of
T15414 31148-31152 CC denotes both
T15415 31153-31156 DT denotes the
T15416 31157-31170 JJ denotes cysteine-rich
T15417 31171-31174 CC denotes and
T15418 31175-31188 JJ denotes arginine-rich
T15419 31189-31196 NN denotes domains
T15420 31197-31199 IN denotes of
T15421 31200-31203 NN denotes Tat
T15422 31204-31206 TO denotes to
T15423 31207-31214 VB denotes enhance
T15424 31215-31218 DT denotes the
T15425 31219-31224 NN denotes NF-κB
T15426 31225-31233 NN denotes activity
T15427 31233-31234 -COMMA- denotes ,
T15428 31235-31245 VB denotes suggesting
T15429 31246-31250 IN denotes that
T15430 31251-31254 DT denotes the
T15431 31255-31268 NN denotes up-regulation
T15432 31269-31271 IN denotes of
T15433 31272-31288 JJ denotes NF-κB-responsive
T15434 31289-31294 NN denotes genes
T15435 31295-31297 IN denotes by
T15436 31298-31301 NN denotes Tat
T15437 31302-31307 MD denotes might
T15438 31308-31313 VB denotes occur
T15439 31314-31321 IN denotes through
T15440 31322-31330 JJ denotes physical
T15441 31331-31342 NN denotes interaction
T15442 31343-31345 IN denotes of
T15443 31346-31349 DT denotes the
T15444 31350-31355 JJ denotes viral
T15445 31356-31363 NN denotes protein
T15446 31364-31368 IN denotes with
T15447 31369-31372 NN denotes p65
T15448 31373-31376 CC denotes and
T15449 31377-31382 NN denotes IκB-α
T15450 32978-32984 NN denotes MIP-1α
T15451 32984-32985 -COMMA- denotes ,
T15452 32986-32991 WDT denotes which
T15453 32992-32995 VB denotes was
T15454 32996-32999 DT denotes the
T15455 33000-33006 RB denotes mostly
T15456 33007-33016 VB denotes activated
T15457 33017-33021 NN denotes gene
T15458 33022-33024 IN denotes by
T15459 33025-33028 NN denotes Tat
T15460 33028-33029 -COMMA- denotes ,
T15461 33030-33037 VB denotes encodes
T15462 33038-33041 IN denotes for
T15463 33042-33043 DT denotes a
T15464 33044-33053 NN denotes chemokine
T15465 33054-33058 WDT denotes that
T15466 33059-33067 VB denotes promotes
T15467 33068-33071 DT denotes the
T15468 33072-33083 NN denotes recruitment
T15469 33084-33086 IN denotes of
T15470 33087-33103 JJ denotes pro-inflammatory
T15471 33104-33109 NN denotes cells
T15472 33110-33111 -LRB- denotes (
T15473 33111-33113 CD denotes 56
T15474 33113-33114 -RRB- denotes )
T15475 33116-33128 RB denotes Consistently
T15476 33129-33133 IN denotes with
T15477 33134-33137 PRP-DOLLAR- denotes our
T15478 33138-33146 NN denotes findings
T15479 33146-33147 -COMMA- denotes ,
T15480 33148-33154 NN denotes MIP-1α
T15481 33155-33165 NN denotes expression
T15482 33166-33169 VB denotes was
T15483 33170-33179 VB denotes increased
T15484 33180-33182 IN denotes in
T15485 33183-33188 JJ denotes glial
T15486 33189-33194 NN denotes cells
T15487 33195-33198 CC denotes and
T15488 33199-33204 NN denotes lymph
T15489 33205-33210 NN denotes nodes
T15490 33211-33213 IN denotes of
T15491 33214-33218 NN denotes AIDS
T15492 33219-33227 NN denotes patients
T15493 33228-33229 -LRB- denotes (
T15494 33229-33234 CD denotes 57,58
T15495 33234-33235 -RRB- denotes )
T15496 33235-33236 -COLON- denotes ;
T15497 33237-33245 RB denotes moreover
T15498 33245-33246 -COMMA- denotes ,
T15499 33247-33253 NN denotes MIP-1α
T15500 33254-33264 NN denotes production
T15501 33265-33268 VB denotes was
T15502 33269-33276 VB denotes induced
T15503 33277-33279 IN denotes by
T15504 33280-33285 NN denotes HIV-1
T15505 33286-33295 NN denotes infection
T15506 33296-33297 -LRB- denotes (
T15507 33297-33302 CD denotes 59,60
T15508 33302-33303 -RRB- denotes )
T15509 33304-33307 CC denotes and
T15510 33308-33311 NN denotes Tat
T15511 33312-33319 NN denotes protein
T15512 33320-33321 -LRB- denotes (
T15513 33321-33329 CD denotes 57,61,62
T15514 33329-33330 -RRB- denotes )
T15515 33332-33335 DT denotes The
T15516 33336-33351 JJ denotes transcriptional
T15517 33352-33362 NN denotes regulation
T15518 33363-33365 IN denotes of
T15519 33366-33372 NN denotes MIP-1α
T15520 33373-33376 VB denotes has
T15521 33377-33381 VB denotes been
T15522 33382-33388 RB denotes poorly
T15523 33389-33402 VB denotes characterized
T15524 33404-33416 JJ denotes Jaspar-based
T15525 33417-33425 NN denotes analysis
T15526 33426-33427 -LRB- denotes (
T15527 33427-33431 NN denotes http
T15528 33431-33432 -COLON- denotes :
T15529 33432-33453 LS denotes //jaspar.genereg.net/
T15530 33453-33454 -RRB- denotes )
T15531 33455-33464 VB denotes predicted
T15532 33465-33470 CD denotes three
T15533 33471-33479 JJ denotes putative
T15534 33480-33485 NN denotes NF-κB
T15535 33486-33495 NN denotes enhancers
T15536 33496-33498 IN denotes in
T15537 33499-33502 DT denotes the
T15538 33503-33511 JJ denotes proximal
T15539 33512-33520 NN denotes promoter
T15540 33521-33527 NN denotes region
T15541 33528-33530 IN denotes of
T15542 33531-33534 DT denotes the
T15543 33535-33541 NN denotes MIP-1α
T15544 33542-33546 NN denotes gene
T15545 33546-33547 -COLON- denotes :
T15546 33548-33554 NN denotes NF-κB1
T15547 33554-33555 -COMMA- denotes ,
T15548 33556-33567 CD denotes −1023/−1014
T15549 33568-33579 NN denotes nucleotides
T15550 33579-33580 -COLON- denotes ;
T15551 33581-33587 NN denotes NF-κB2
T15552 33587-33588 -COMMA- denotes ,
T15553 33589-33598 CD denotes −661/−652
T15554 33599-33610 NN denotes nucleotides
T15555 33610-33611 -COLON- denotes ;
T15556 33612-33618 NN denotes NF-κB3
T15557 33618-33619 -COMMA- denotes ,
T15558 33620-33629 CD denotes +370/+379
T15559 33630-33641 NN denotes nucleotides
T15560 33642-33643 -LRB- denotes (
T15561 33643-33656 JJ denotes Supplementary
T15562 33657-33663 NN denotes Figure
T15563 33664-33667 NN denotes S3A
T15564 33667-33668 -RRB- denotes )
T15565 33670-33672 TO denotes To
T15566 33673-33681 VB denotes validate
T15567 33682-33685 DT denotes the
T15568 33686-33695 VB denotes predicted
T15569 33696-33701 NN denotes NF-κB
T15570 33702-33709 NN denotes binding
T15571 33710-33715 NN denotes sites
T15572 33716-33718 IN denotes of
T15573 33719-33722 DT denotes the
T15574 33723-33729 NN denotes MIP-1α
T15575 33730-33738 NN denotes promoter
T15576 33738-33739 -COMMA- denotes ,
T15577 33740-33742 PRP denotes we
T15578 33743-33753 VB denotes stimulated
T15579 33754-33758 NN denotes HeLa
T15580 33759-33764 NN denotes cells
T15581 33765-33769 IN denotes with
T15582 33770-33775 NN denotes TNF-α
T15583 33775-33776 -COMMA- denotes ,
T15584 33777-33778 DT denotes a
T15585 33779-33789 JJ denotes well-known
T15586 33790-33795 NN denotes NF-κB
T15587 33796-33803 NN denotes inducer
T15588 33803-33804 -COMMA- denotes ,
T15589 33805-33808 CC denotes and
T15590 33809-33817 VB denotes measured
T15591 33818-33821 DT denotes the
T15592 33822-33832 NN denotes expression
T15593 33833-33839 NN denotes levels
T15594 33840-33842 IN denotes of
T15595 33843-33849 NN denotes MIP-1α
T15596 33850-33852 IN denotes by
T15597 33853-33862 JJ denotes real-time
T15598 33863-33866 NN denotes PCR
T15599 33866-33867 -COMMA- denotes ,
T15600 33868-33871 CC denotes and
T15601 33872-33875 DT denotes the
T15602 33876-33879 NN denotes p65
T15603 33880-33889 NN denotes occupancy
T15604 33890-33892 IN denotes of
T15605 33893-33896 DT denotes the
T15606 33897-33902 NN denotes NF-κB
T15607 33903-33908 NN denotes sites
T15608 33909-33911 IN denotes by
T15609 33912-33916 NN denotes ChIP
T15610 33918-33923 NN denotes TNF-α
T15611 33924-33933 VB denotes activated
T15612 33934-33937 DT denotes the
T15613 33938-33948 NN denotes expression
T15614 33949-33951 IN denotes of
T15615 33952-33958 NN denotes MIP-1α
T15616 33959-33962 CC denotes and
T15617 33963-33970 VB denotes induced
T15618 33971-33974 DT denotes the
T15619 33975-33978 NN denotes p65
T15620 33979-33990 NN denotes recruitment
T15621 33991-33993 TO denotes to
T15622 33994-33997 DT denotes the
T15623 33998-34004 NN denotes NF-κB1
T15624 34005-34009 NN denotes site
T15625 34010-34012 IN denotes of
T15626 34013-34019 NN denotes MIP-1α
T15627 34020-34027 IN denotes without
T15628 34028-34037 VB denotes affecting
T15629 34038-34041 DT denotes the
T15630 34042-34051 NN denotes occupancy
T15631 34052-34054 IN denotes of
T15632 34055-34058 DT denotes the
T15633 34059-34067 JJ denotes putative
T15634 34068-34074 NN denotes NF-κB2
T15635 34075-34078 CC denotes and
T15636 34079-34085 NN denotes NF-κB3
T15637 34086-34091 NN denotes sites
T15638 34092-34093 -LRB- denotes (
T15639 34093-34106 JJ denotes Supplementary
T15640 34107-34113 NNP denotes Figure
T15641 34114-34117 NN denotes S3B
T15642 34118-34121 CC denotes and
T15643 34122-34125 NN denotes S3C
T15644 34125-34126 -RRB- denotes )
T15645 34128-34131 NN denotes Tat
T15646 34132-34136 RB denotes also
T15647 34137-34145 VB denotes promoted
T15648 34146-34149 DT denotes the
T15649 34150-34161 NN denotes recruitment
T15650 34162-34164 IN denotes of
T15651 34165-34168 NN denotes p65
T15652 34169-34171 TO denotes to
T15653 34172-34175 DT denotes the
T15654 34176-34182 NN denotes NF-κB1
T15655 34183-34187 NN denotes site
T15656 34188-34190 IN denotes of
T15657 34191-34197 NN denotes MIP-1α
T15658 34197-34198 -COMMA- denotes ,
T15659 34199-34204 IN denotes while
T15660 34205-34207 PRP denotes it
T15661 34208-34211 VB denotes did
T15662 34212-34215 RB denotes not
T15663 34216-34222 VB denotes affect
T15664 34223-34226 DT denotes the
T15665 34227-34235 JJ denotes putative
T15666 34236-34242 NN denotes NF-κB2
T15667 34243-34246 CC denotes and
T15668 34247-34253 NN denotes NF-κB3
T15669 34254-34259 NN denotes sites
T15670 34260-34261 -LRB- denotes (
T15671 34261-34274 JJ denotes Supplementary
T15672 34275-34281 NNP denotes Figure
T15673 34282-34285 NN denotes S3D
T15674 34285-34286 -RRB- denotes )
T15675 34288-34298 RB denotes Altogether
T15676 34299-34304 DT denotes these
T15677 34305-34312 NN denotes results
T15678 34313-34322 VB denotes indicated
T15679 34323-34327 IN denotes that
T15680 34328-34331 DT denotes the
T15681 34332-34338 NN denotes NF-κB1
T15682 34339-34343 NN denotes site
T15683 34344-34347 VB denotes was
T15684 34348-34351 DT denotes the
T15685 34352-34356 RB denotes only
T15686 34357-34366 JJ denotes effective
T15687 34367-34372 NN denotes NF-κB
T15688 34373-34381 NN denotes enhancer
T15689 34382-34384 IN denotes of
T15690 34385-34388 DT denotes the
T15691 34389-34395 NN denotes MIP-1α
T15692 34396-34404 NN denotes promoter
T15693 34405-34407 IN denotes in
T15694 34408-34416 NN denotes response
T15695 34417-34419 TO denotes to
T15696 34420-34425 NN denotes TNF-α
T15697 34426-34429 CC denotes and
T15698 34430-34433 NN denotes Tat
T15699 34435-34444 RB denotes Similarly
T15700 34445-34447 TO denotes to
T15701 34448-34454 NN denotes MIP-1α
T15702 34454-34455 -COMMA- denotes ,
T15703 34456-34459 NN denotes Tat
T15704 34460-34469 VB denotes increased
T15705 34470-34473 DT denotes the
T15706 34474-34485 NN denotes recruitment
T15707 34486-34488 IN denotes of
T15708 34489-34492 NN denotes p65
T15709 34493-34495 TO denotes to
T15710 34496-34499 DT denotes the
T15711 34500-34505 NN denotes NF-κB
T15712 34506-34515 NN denotes enhancers
T15713 34516-34518 IN denotes of
T15714 34519-34523 NN denotes CSF3
T15715 34523-34524 -COMMA- denotes ,
T15716 34525-34528 NN denotes LTA
T15717 34528-34529 -COMMA- denotes ,
T15718 34530-34536 NN denotes NFKBIA
T15719 34537-34540 CC denotes and
T15720 34541-34545 NN denotes TLR2
T15721 34545-34546 -COMMA- denotes ,
T15722 34547-34552 IN denotes while
T15723 34553-34555 PRP denotes it
T15724 34556-34559 VB denotes was
T15725 34560-34571 JJ denotes ineffective
T15726 34572-34574 IN denotes at
T15727 34575-34578 DT denotes the
T15728 34579-34588 NN denotes promoters
T15729 34589-34591 IN denotes of
T15730 34592-34597 NN denotes GAPDH
T15731 34598-34601 CC denotes and
T15732 34602-34606 NN denotes ACTB
T15733 34607-34608 -LRB- denotes (
T15734 34608-34614 NN denotes Figure
T15735 34615-34617 NN denotes 5H
T15736 34617-34618 -RRB- denotes )
T15737 34620-34622 IN denotes By
T15738 34623-34627 NN denotes ChIP
T15739 34627-34628 -COMMA- denotes ,
T15740 34629-34632 NN denotes Tat
T15741 34633-34638 VB denotes bound
T15742 34639-34641 TO denotes to
T15743 34642-34645 DT denotes the
T15744 34646-34662 JJ denotes NF-κB-responsive
T15745 34663-34672 NN denotes promoters
T15746 34672-34673 -COMMA- denotes ,
T15747 34674-34677 CC denotes and
T15748 34678-34681 RB denotes not
T15749 34682-34684 TO denotes to
T15750 34685-34688 DT denotes the
T15751 34689-34694 NN denotes GAPDH
T15752 34695-34698 CC denotes and
T15753 34699-34703 NN denotes ACTB
T15754 34704-34713 NN denotes promoters
T15755 34713-34714 -COMMA- denotes ,
T15756 34715-34719 IN denotes with
T15757 34720-34724 NN denotes loss
T15758 34725-34727 IN denotes of
T15759 34728-34735 NN denotes binding
T15760 34736-34745 VB denotes following
T15761 34746-34749 NN denotes p65
T15762 34750-34753 NN denotes RNA
T15763 34754-34766 NN denotes interference
T15764 34767-34768 -LRB- denotes (
T15765 34768-34774 NN denotes Figure
T15766 34775-34777 NN denotes 5I
T15767 34777-34778 -RRB- denotes )
T15768 34778-34779 -COMMA- denotes ,
T15769 34780-34790 VB denotes suggesting
T15770 34791-34795 IN denotes that
T15771 34796-34799 NN denotes Tat
T15772 34800-34809 NN denotes occupancy
T15773 34810-34818 VB denotes occurred
T15774 34819-34822 IN denotes via
T15775 34823-34826 NN denotes p65
T15776 34827-34838 NN denotes interaction
T15777 34840-34842 IN denotes As
T15778 34843-34853 JJ denotes additional
T15779 34854-34862 NN denotes findings
T15780 34862-34863 -COMMA- denotes ,
T15781 34864-34869 NN denotes IκB-α
T15782 34870-34873 VB denotes was
T15783 34874-34902 JJ denotes chromatin-immunoprecipitated
T15784 34903-34905 IN denotes at
T15785 34906-34909 DT denotes the
T15786 34910-34915 NN denotes NF-κB
T15787 34916-34925 NN denotes enhancers
T15788 34926-34928 IN denotes in
T15789 34929-34936 NN denotes absence
T15790 34937-34939 IN denotes of
T15791 34940-34943 NN denotes Tat
T15792 34943-34944 -COMMA- denotes ,
T15793 34945-34948 CC denotes and
T15794 34949-34951 PRP denotes it
T15795 34952-34955 VB denotes was
T15796 34956-34969 RB denotes significantly
T15797 34970-34977 VB denotes removed
T15798 34978-34980 IN denotes in
T15799 34981-34989 NN denotes presence
T15800 34990-34992 IN denotes of
T15801 34993-34996 NN denotes Tat
T15802 34996-34997 -COMMA- denotes ,
T15803 34998-35000 CC denotes or
T15804 35001-35010 VB denotes following
T15805 35011-35016 JJ denotes IκB-α
T15806 35017-35020 NN denotes RNA
T15807 35021-35033 NN denotes interference
T15808 35034-35035 -LRB- denotes (
T15809 35035-35041 NN denotes Figure
T15810 35042-35044 NN denotes 5J
T15811 35044-35045 -RRB- denotes )
T15812 35045-35046 -COMMA- denotes ,
T15813 35047-35057 VB denotes indicating
T15814 35058-35062 IN denotes that
T15815 35063-35066 NN denotes Tat
T15816 35067-35076 VB denotes displaced
T15817 35077-35082 JJ denotes IκB-α
T15818 35083-35087 IN denotes from
T15819 35088-35097 NN denotes promoters
T17795 35100-35102 IN denotes In
T17796 35103-35117 JJ denotes HIV-1-infected
T17797 35118-35127 NN denotes monocytes
T17798 35128-35131 NN denotes Tat
T17799 35132-35140 VB denotes sustains
T17800 35141-35144 DT denotes the
T17801 35145-35150 NN denotes NF-κB
T17802 35151-35159 NN denotes activity
T17803 35160-35163 CC denotes and
T17804 35164-35172 VB denotes promotes
T17805 35173-35176 DT denotes the
T17806 35177-35192 JJ denotes transcriptional
T17807 35193-35203 NN denotes activation
T17808 35204-35206 IN denotes of
T17809 35207-35213 NN denotes MIP-1α
T17810 35214-35216 IN denotes by
T17811 35217-35228 VB denotes interacting
T17812 35229-35233 IN denotes with
T17813 35234-35239 NN denotes IκB-α
T17814 35240-35243 CC denotes and
T17815 35244-35247 NN denotes p65
T17816 35248-35250 PRP denotes We
T17817 35251-35255 RB denotes next
T17818 35256-35264 VB denotes analysed
T17819 35265-35272 IN denotes whether
T17820 35273-35276 NN denotes Tat
T17821 35277-35285 VB denotes affected
T17822 35286-35289 DT denotes the
T17823 35290-35295 NN denotes NF-κB
T17824 35296-35304 NN denotes activity
T17825 35305-35308 CC denotes and
T17826 35309-35312 DT denotes the
T17827 35313-35323 NN denotes expression
T17828 35324-35326 IN denotes of
T17829 35327-35333 NN denotes MIP-1α
T17830 35334-35336 IN denotes in
T17831 35337-35340 DT denotes the
T17832 35341-35347 NN denotes course
T17833 35348-35350 IN denotes of
T17834 35351-35356 NN denotes HIV-1
T17835 35357-35366 NN denotes infection
T17836 35368-35370 TO denotes To
T17837 35371-35377 VB denotes detect
T17838 35378-35381 DT denotes the
T17839 35382-35385 NN denotes Tat
T17840 35386-35393 NN denotes protein
T17841 35393-35394 -COMMA- denotes ,
T17842 35395-35397 PRP denotes we
T17843 35398-35406 VB denotes produced
T17844 35407-35411 NN denotes HXB2
T17845 35412-35427 JJ denotes Env-pseudotyped
T17846 35428-35447 NN denotes NL4-3.FLAG-Tat.R−E−
T17847 35448-35455 NN denotes virions
T17848 35455-35456 -COMMA- denotes ,
T17849 35457-35462 WDT denotes which
T17850 35463-35467 VB denotes were
T17851 35468-35472 VB denotes used
T17852 35473-35475 IN denotes in
T17853 35476-35488 JJ denotes single-round
T17854 35489-35498 NN denotes infection
T17855 35499-35501 IN denotes of
T17856 35502-35506 NN denotes U937
T17857 35506-35507 -COMMA- denotes ,
T17858 35508-35509 DT denotes a
T17859 35510-35515 JJ denotes human
T17860 35516-35525 JJ denotes monocytic
T17861 35526-35530 NN denotes cell
T17862 35531-35535 NN denotes line
T17863 35537-35542 NN denotes Cells
T17864 35543-35547 VB denotes were
T17865 35548-35559 VB denotes transfected
T17866 35560-35564 IN denotes with
T17867 35565-35570 NN denotes siRNA
T17868 35571-35574 NN denotes Tat
T17869 35574-35575 -COMMA- denotes ,
T17870 35576-35581 NN denotes siRNA
T17871 35582-35589 NN denotes control
T17872 35590-35592 CC denotes or
T17873 35593-35597 VB denotes left
T17874 35598-35611 JJ denotes untransfected
T17875 35612-35614 TO denotes to
T17876 35615-35623 VB denotes modulate
T17877 35624-35627 DT denotes the
T17878 35628-35631 NN denotes Tat
T17879 35632-35642 NN denotes expression
T17880 35642-35643 -COMMA- denotes ,
T17881 35644-35647 CC denotes and
T17882 35648-35652 RB denotes then
T17883 35653-35661 VB denotes analysed
T17884 35662-35665 IN denotes for
T17885 35666-35669 DT denotes the
T17886 35670-35677 NN denotes kinetic
T17887 35678-35680 IN denotes of
T17888 35681-35686 NN denotes NF-κB
T17889 35687-35697 NN denotes activation
T17890 35698-35707 VB denotes following
T17891 35708-35713 JJ denotes viral
T17892 35714-35723 NN denotes infection
T17893 35725-35728 DT denotes The
T17894 35729-35739 NN denotes expression
T17895 35740-35742 IN denotes of
T17896 35743-35746 NN denotes Tat
T17897 35747-35750 CC denotes and
T17898 35751-35754 NN denotes p24
T17899 35755-35758 VB denotes was
T17900 35759-35767 VB denotes detected
T17901 35768-35770 IN denotes at
T17902 35771-35773 CD denotes 3-
T17903 35774-35776 TO denotes to
T17904 35777-35781 JJ denotes 12-h
T17905 35782-35796 NN denotes post-infection
T17906 35796-35797 -COMMA- denotes ,
T17907 35798-35803 IN denotes while
T17908 35804-35806 PRP denotes it
T17909 35807-35810 VB denotes was
T17910 35811-35817 RB denotes barely
T17911 35818-35826 VB denotes detected
T17912 35827-35829 IN denotes in
T17913 35830-35835 NN denotes siRNA
T17914 35836-35851 JJ denotes Tat-transfected
T17915 35852-35857 NN denotes cells
T17916 35858-35859 -LRB- denotes (
T17917 35859-35865 NN denotes Figure
T17918 35866-35868 NN denotes 6A
T17919 35868-35869 -RRB- denotes )
T17920 38126-38129 DT denotes The
T17921 38130-38135 NN denotes NF-κB
T17922 38136-38144 NN denotes activity
T17923 38144-38145 -COMMA- denotes ,
T17924 38146-38148 IN denotes as
T17925 38149-38157 VB denotes measured
T17926 38158-38160 IN denotes by
T17927 38161-38164 NN denotes p65
T17928 38165-38168 NN denotes DNA
T17929 38169-38176 NN denotes binding
T17930 38176-38177 -COMMA- denotes ,
T17931 38178-38181 VB denotes was
T17932 38182-38189 VB denotes induced
T17933 38190-38192 IN denotes at
T17934 38193-38196 JJ denotes 3-h
T17935 38197-38211 NN denotes post-infection
T17936 38212-38214 IN denotes in
T17937 38215-38219 CC denotes both
T17938 38220-38232 JJ denotes Tat-positive
T17939 38233-38234 -LRB- denotes (
T17940 38234-38236 DT denotes no
T17941 38237-38242 NN denotes siRNA
T17942 38243-38246 CC denotes and
T17943 38247-38252 NN denotes siRNA
T17944 38253-38260 NN denotes control
T17945 38260-38261 -RRB- denotes )
T17946 38262-38265 CC denotes and
T17947 38266-38278 JJ denotes Tat-negative
T17948 38279-38284 NN denotes cells
T17949 38285-38286 -LRB- denotes (
T17950 38286-38291 NN denotes siRNA
T17951 38292-38295 NN denotes Tat
T17952 38295-38296 -RRB- denotes )
T17953 38296-38297 -COMMA- denotes ,
T17954 38298-38301 CC denotes and
T17955 38302-38311 VB denotes increased
T17956 38312-38314 IN denotes at
T17957 38315-38319 NN denotes 12 h
T17958 38320-38324 RB denotes only
T17959 38325-38327 IN denotes in
T17960 38328-38340 JJ denotes Tat-positive
T17961 38341-38346 NN denotes cells
T17962 38347-38348 -LRB- denotes (
T17963 38348-38354 NN denotes Figure
T17964 38355-38357 NN denotes 6B
T17965 38357-38358 -RRB- denotes )
T17966 38360-38371 NN denotes Degradation
T17967 38372-38374 IN denotes of
T17968 38375-38380 NN denotes IκB-α
T17969 38381-38384 VB denotes was
T17970 38385-38393 VB denotes observed
T17971 38394-38396 IN denotes at
T17972 38397-38400 JJ denotes 3-h
T17973 38401-38415 NN denotes post-infection
T17974 38415-38416 -COMMA- denotes ,
T17975 38417-38420 CC denotes and
T17976 38421-38424 VB denotes was
T17977 38425-38433 VB denotes followed
T17978 38434-38436 IN denotes by
T17979 38437-38439 FW denotes de
T17980 38440-38444 FW denotes novo
T17981 38445-38454 NN denotes synthesis
T17982 38455-38457 IN denotes of
T17983 38458-38463 NN denotes IκB-α
T17984 38464-38466 IN denotes at
T17985 38467-38471 CD denotes 12 h
T17986 38472-38485 RB denotes independently
T17987 38486-38488 IN denotes of
T17988 38489-38492 DT denotes the
T17989 38493-38496 NN denotes Tat
T17990 38497-38505 NN denotes presence
T17991 38506-38507 -LRB- denotes (
T17992 38507-38513 NN denotes Figure
T17993 38514-38516 NN denotes 6C
T17994 38516-38517 -RRB- denotes )
T17995 38519-38531 RB denotes Consistently
T17996 38531-38532 -COMMA- denotes ,
T17997 38533-38536 DT denotes the
T17998 38537-38540 NN denotes IKK
T17999 38541-38549 NN denotes activity
T18000 38550-38553 VB denotes was
T18001 38554-38561 VB denotes induced
T18002 38562-38564 IN denotes at
T18003 38565-38568 JJ denotes 3-h
T18004 38569-38583 NN denotes post-infection
T18005 38584-38587 CC denotes and
T18006 38588-38594 VB denotes turned
T18007 38595-38598 RP denotes off
T18008 38599-38601 IN denotes at
T18009 38602-38606 CD denotes 12 h
T18010 38607-38620 RB denotes independently
T18011 38621-38623 IN denotes of
T18012 38624-38627 DT denotes the
T18013 38628-38631 NN denotes Tat
T18014 38632-38640 NN denotes presence
T18015 38641-38642 -LRB- denotes (
T18016 38642-38648 NN denotes Figure
T18017 38649-38651 NN denotes 6D
T18018 38651-38652 -RRB- denotes )
T18019 38654-38659 DT denotes These
T18020 38660-38667 NN denotes results
T18021 38668-38674 VB denotes agreed
T18022 38675-38679 IN denotes with
T18023 38680-38683 DT denotes the
T18024 38684-38691 NN denotes kinetic
T18025 38692-38694 IN denotes of
T18026 38695-38700 NN denotes NF-κB
T18027 38701-38711 NN denotes activation
T18028 38712-38714 IN denotes in
T18029 38715-38727 JJ denotes single-round
T18030 38728-38733 NN denotes HIV-1
T18031 38734-38743 NN denotes infection
T18032 38744-38746 IN denotes of
T18033 38747-38753 NN denotes Jurkat
T18034 38754-38759 NN denotes cells
T18035 38760-38761 -LRB- denotes (
T18036 38761-38767 NN denotes Figure
T18037 38768-38769 CD denotes 1
T18038 38769-38770 -RRB- denotes )
T18039 38770-38771 -COMMA- denotes ,
T18040 38772-38775 CC denotes and
T18041 38776-38783 RB denotes further
T18042 38784-38793 VB denotes supported
T18043 38794-38797 DT denotes the
T18044 38798-38809 NN denotes requirement
T18045 38810-38812 IN denotes of
T18046 38813-38818 JJ denotes viral
T18047 38819-38829 NN denotes expression
T18048 38830-38832 TO denotes to
T18049 38833-38843 VB denotes counteract
T18050 38844-38847 DT denotes the
T18051 38848-38863 JJ denotes post-activation
T18052 38864-38868 NN denotes turn
T18053 38869-38872 RP denotes off
T18054 38873-38875 IN denotes of
T18055 38876-38881 NN denotes NF-κB
T18056 38883-38885 IN denotes In
T18057 38886-38900 JJ denotes HIV-1-infected
T18058 38901-38905 NN denotes U937
T18059 38906-38911 NN denotes cells
T18060 38911-38912 -COMMA- denotes ,
T18061 38913-38916 DT denotes the
T18062 38917-38927 JJ denotes endogenous
T18063 38928-38931 NN denotes Tat
T18064 38932-38935 VB denotes was
T18065 38936-38956 VB denotes coimmunoprecipitated
T18066 38957-38961 IN denotes with
T18067 38962-38967 NN denotes IκB-α
T18068 38968-38971 CC denotes and
T18069 38972-38975 NN denotes p65
T18070 38976-38977 -LRB- denotes (
T18071 38977-38983 NN denotes Figure
T18072 38984-38986 NN denotes 6E
T18073 38986-38987 -RRB- denotes )
T18074 38987-38988 -COMMA- denotes ,
T18075 38989-38992 CC denotes and
T18076 38993-39002 VB denotes activated
T18077 39003-39006 DT denotes the
T18078 39007-39013 NN denotes MIP-1α
T18079 39014-39024 NN denotes expression
T18080 39025-39027 IN denotes in
T18081 39028-39029 DT denotes a
T18082 39030-39043 JJ denotes p65-dependent
T18083 39044-39050 NN denotes manner
T18084 39050-39051 -COMMA- denotes ,
T18085 39052-39054 IN denotes as
T18086 39055-39060 VB denotes shown
T18087 39061-39063 IN denotes by
T18088 39064-39067 DT denotes the
T18089 39068-39072 NN denotes lack
T18090 39073-39075 IN denotes of
T18091 39076-39082 NN denotes effect
T18092 39083-39092 VB denotes following
T18093 39093-39096 NN denotes RNA
T18094 39097-39109 NN denotes interference
T18095 39110-39112 IN denotes of
T18096 39113-39116 NN denotes Tat
T18097 39117-39119 CC denotes or
T18098 39120-39123 NN denotes p65
T18099 39124-39125 -LRB- denotes (
T18100 39125-39131 NN denotes Figure
T18101 39132-39134 NN denotes 6F
T18102 39134-39135 -RRB- denotes )
T18103 39137-39145 RB denotes Moreover
T18104 39145-39146 -COMMA- denotes ,
T18105 39147-39150 NN denotes Tat
T18106 39151-39154 CC denotes and
T18107 39155-39158 NN denotes p65
T18108 39159-39163 VB denotes were
T18109 39164-39168 DT denotes both
T18110 39169-39178 VB denotes recruited
T18111 39179-39181 TO denotes to
T18112 39182-39185 DT denotes the
T18113 39186-39191 NN denotes NF-κB
T18114 39192-39200 NN denotes enhancer
T18115 39201-39203 IN denotes of
T18116 39204-39210 NN denotes MIP-1α
T18117 39210-39211 -COMMA- denotes ,
T18118 39212-39217 IN denotes while
T18119 39218-39221 DT denotes the
T18120 39222-39225 NN denotes p65
T18121 39226-39235 NN denotes occupancy
T18122 39236-39239 VB denotes was
T18123 39240-39249 VB denotes abolished
T18124 39250-39252 IN denotes by
T18125 39253-39258 NN denotes siRNA
T18126 39259-39262 NN denotes Tat
T18127 39263-39264 -LRB- denotes (
T18128 39264-39270 NN denotes Figure
T18129 39271-39273 NN denotes 6G
T18130 39274-39277 CC denotes and
T18131 39278-39279 NN denotes H
T18132 39279-39280 -RRB- denotes )
T18133 39282-39292 RB denotes Altogether
T18134 39293-39298 DT denotes these
T18135 39299-39306 NN denotes results
T18136 39307-39316 VB denotes indicated
T18137 39317-39321 IN denotes that
T18138 39322-39324 IN denotes in
T18139 39325-39331 JJ denotes single
T18140 39332-39337 JJ denotes round
T18141 39338-39343 NN denotes HIV-1
T18142 39344-39353 NN denotes infection
T18143 39354-39357 NN denotes Tat
T18144 39358-39368 VB denotes associated
T18145 39369-39373 IN denotes with
T18146 39374-39379 NN denotes IκB-α
T18147 39380-39383 CC denotes and
T18148 39384-39387 NN denotes p65
T18149 39387-39388 -COMMA- denotes ,
T18150 39389-39392 CC denotes and
T18151 39393-39400 VB denotes induced
T18152 39401-39404 DT denotes the
T18153 39405-39418 JJ denotes p65-dependent
T18154 39419-39429 NN denotes activation
T18155 39430-39432 IN denotes of
T18156 39433-39439 NN denotes MIP-1α
T18157 39440-39450 NN denotes expression
T18158 39451-39458 IN denotes through
T18159 39459-39468 NN denotes occupancy
T18160 39469-39471 IN denotes of
T18161 39472-39475 DT denotes the
T18162 39476-39482 NN denotes MIP-1α
T18163 39483-39491 NN denotes promoter
T18164 39492-39495 CC denotes and
T18165 39496-39505 VB denotes increased
T18166 39506-39517 NN denotes recruitment
T18167 39518-39520 IN denotes of
T18168 39521-39524 NN denotes p65
T19911 39538-39542 DT denotes This
T19912 39543-39548 NN denotes study
T19913 39549-39556 VB denotes reports
T19914 39557-39558 DT denotes a
T19915 39559-39564 JJ denotes novel
T19916 39565-39574 NN denotes mechanism
T19917 39575-39577 IN denotes of
T19918 39578-39583 NN denotes NF-κB
T19919 39584-39594 NN denotes activation
T19920 39595-39597 IN denotes by
T19921 39598-39601 DT denotes the
T19922 39602-39607 NN denotes HIV-1
T19923 39608-39611 NN denotes Tat
T19924 39612-39626 NN denotes transactivator
T19925 39628-39633 VB denotes Based
T19926 39634-39636 IN denotes on
T19927 39637-39640 DT denotes the
T19928 39641-39649 NN denotes evidence
T19929 39650-39654 IN denotes that
T19930 39655-39658 NN denotes Tat
T19931 39659-39667 VB denotes enhanced
T19932 39668-39671 DT denotes the
T19933 39672-39687 JJ denotes transcriptional
T19934 39688-39696 NN denotes activity
T19935 39697-39699 IN denotes of
T19936 39700-39703 DT denotes the
T19937 39704-39707 NN denotes p65
T19938 39708-39715 NN denotes subunit
T19939 39716-39718 IN denotes of
T19940 39719-39724 NN denotes NF-κB
T19941 39725-39726 -LRB- denotes (
T19942 39726-39734 CD denotes 49,63,64
T19943 39734-39735 -RRB- denotes )
T19944 39735-39736 -COMMA- denotes ,
T19945 39737-39740 CC denotes and
T19946 39741-39751 RB denotes physically
T19947 39752-39762 VB denotes interacted
T19948 39763-39767 IN denotes with
T19949 39768-39771 DT denotes the
T19950 39772-39777 JJ denotes IκB-α
T19951 39778-39787 NN denotes repressor
T19952 39788-39789 -LRB- denotes (
T19953 39789-39794 CD denotes 50,51
T19954 39794-39795 -RRB- denotes )
T19955 39795-39796 -COMMA- denotes ,
T19956 39797-39799 PRP denotes we
T19957 39800-39812 VB denotes investigated
T19958 39813-39816 DT denotes the
T19959 39817-39828 NN denotes possibility
T19960 39829-39833 IN denotes that
T19961 39834-39837 NN denotes Tat
T19962 39838-39843 MD denotes could
T19963 39844-39852 VB denotes activate
T19964 39853-39858 NN denotes NF-κB
T19965 39859-39862 IN denotes via
T19966 39863-39869 JJ denotes direct
T19967 39870-39881 NN denotes interaction
T19968 39882-39886 IN denotes with
T19969 39887-39892 NN denotes IκB-α
T19970 39893-39896 CC denotes and
T19971 39897-39900 NN denotes p65
T19972 39902-39904 TO denotes To
T19973 39905-39909 DT denotes this
T19974 39910-39913 NN denotes end
T19975 39913-39914 -COMMA- denotes ,
T19976 39915-39918 DT denotes the
T19977 39919-39924 NN denotes NF-κB
T19978 39925-39933 NN denotes activity
T19979 39934-39937 VB denotes was
T19980 39938-39947 VB denotes monitored
T19981 39948-39950 IN denotes in
T19982 39951-39957 JJ denotes single
T19983 39958-39963 JJ denotes round
T19984 39964-39969 NN denotes HIV-1
T19985 39970-39979 NN denotes infection
T19986 39980-39985 VB denotes using
T19987 39986-39989 NN denotes RNA
T19988 39990-40002 NN denotes interference
T19989 40003-40005 TO denotes to
T19990 40006-40013 VB denotes silence
T19991 40014-40017 DT denotes the
T19992 40018-40021 NN denotes Tat
T19993 40022-40032 NN denotes expression
T19994 40034-40036 IN denotes By
T19995 40037-40041 DT denotes this
T19996 40042-40050 NN denotes approach
T19997 40050-40051 -COMMA- denotes ,
T19998 40052-40054 PRP denotes we
T19999 40055-40062 VB denotes avoided
T20000 40063-40066 DT denotes the
T20001 40067-40079 NN denotes perpetuation
T20002 40080-40082 IN denotes of
T20003 40083-40088 NN denotes NF-κB
T20004 40089-40099 NN denotes activation
T20005 40100-40109 NN denotes signaling
T20006 40110-40113 JJ denotes due
T20007 40114-40116 TO denotes to
T20008 40117-40127 JJ denotes subsequent
T20009 40128-40134 NN denotes rounds
T20010 40135-40137 IN denotes of
T20011 40138-40143 JJ denotes viral
T20012 40144-40149 NN denotes entry
T20013 40150-40152 IN denotes in
T20014 40153-40157 NN denotes cell
T20015 40158-40165 NN denotes culture
T20016 40166-40177 NN denotes propagation
T20017 40178-40179 -LRB- denotes (
T20018 40179-40184 CD denotes 30,31
T20019 40184-40185 -RRB- denotes )
T20020 40187-40191 IN denotes Upon
T20021 40192-40197 NN denotes HIV-1
T20022 40198-40207 NN denotes infection
T20023 40207-40208 -COMMA- denotes ,
T20024 40209-40212 DT denotes the
T20025 40213-40218 JJ denotes early
T20026 40219-40224 NN denotes NF-κB
T20027 40225-40235 NN denotes activation
T20028 40236-40244 VB denotes occurred
T20029 40245-40258 RB denotes concomitantly
T20030 40259-40263 IN denotes with
T20031 40264-40267 NN denotes IKK
T20032 40268-40278 NN denotes activation
T20033 40279-40282 CC denotes and
T20034 40283-40288 JJ denotes IκB-α
T20035 40289-40300 NN denotes degradation
T20036 40301-40303 IN denotes in
T20037 40304-40307 DT denotes the
T20038 40308-40315 NN denotes absence
T20039 40316-40318 IN denotes of
T20040 40319-40323 NNP denotes Tat.
T20041 40324-40328 NNP denotes Soon
T20042 40329-40334 IN denotes after
T20043 40335-40338 DT denotes the
T20044 40339-40343 NN denotes shut
T20045 40344-40347 RP denotes off
T20046 40348-40350 IN denotes of
T20047 40351-40354 NN denotes IKK
T20048 40355-40363 NN denotes activity
T20049 40364-40367 CC denotes and
T20050 40368-40371 JJ denotes new
T20051 40372-40381 NN denotes synthesis
T20052 40382-40384 IN denotes of
T20053 40385-40390 NN denotes IκB-α
T20054 40390-40391 -COMMA- denotes ,
T20055 40392-40395 DT denotes the
T20056 40396-40401 NN denotes NF-κB
T20057 40402-40410 NN denotes activity
T20058 40411-40414 VB denotes was
T20059 40415-40419 VB denotes kept
T20060 40420-40428 JJ denotes elevated
T20061 40429-40431 IN denotes in
T20062 40432-40435 DT denotes the
T20063 40436-40444 NN denotes presence
T20064 40445-40447 IN denotes of
T20065 40448-40451 NN denotes Tat
T20066 40451-40452 -COMMA- denotes ,
T20067 40453-40458 IN denotes while
T20068 40459-40461 PRP denotes it
T20069 40462-40465 VB denotes was
T20070 40466-40470 RB denotes down
T20071 40471-40480 VB denotes regulated
T20072 40481-40485 IN denotes upon
T20073 40486-40495 NN denotes silencing
T20074 40496-40498 IN denotes of
T20075 40499-40502 DT denotes the
T20076 40503-40506 NN denotes Tat
T20077 40507-40511 NN denotes gene
T20078 40513-40518 DT denotes These
T20079 40519-40527 NN denotes findings
T20080 40528-40536 VB denotes indicate
T20081 40537-40541 IN denotes that
T20082 40542-40544 IN denotes in
T20083 40545-40551 JJ denotes single
T20084 40552-40557 JJ denotes round
T20085 40558-40563 NN denotes HIV-1
T20086 40564-40573 NN denotes infection
T20087 40573-40574 -COMMA- denotes ,
T20088 40575-40578 NN denotes Tat
T20089 40579-40587 VB denotes enhanced
T20090 40588-40591 DT denotes the
T20091 40592-40597 NN denotes NF-κB
T20092 40598-40606 NN denotes activity
T20093 40607-40614 IN denotes without
T20094 40615-40624 VB denotes affecting
T20095 40625-40628 DT denotes the
T20096 40629-40632 NN denotes IKK
T20097 40633-40641 NN denotes activity
T20098 40642-40645 CC denotes and
T20099 40646-40649 DT denotes the
T20100 40650-40659 NN denotes half-life
T20101 40660-40662 IN denotes of
T20102 40663-40668 NN denotes IκB-α
T20103 40670-40677 JJ denotes Similar
T20104 40678-40685 JJ denotes kinetic
T20105 40686-40688 IN denotes of
T20106 40689-40694 NN denotes NF-κB
T20107 40695-40705 NN denotes activation
T20108 40706-40714 VB denotes occurred
T20109 40715-40719 IN denotes upon
T20110 40720-40731 NN denotes short-pulse
T20111 40732-40734 IN denotes of
T20112 40735-40738 NN denotes PMA
T20113 40739-40741 IN denotes in
T20114 40742-40757 JJ denotes Tat-transfected
T20115 40758-40762 NN denotes HeLa
T20116 40763-40768 NN denotes cells
T20117 40768-40769 -COMMA- denotes ,
T20118 40770-40775 WRB denotes where
T20119 40776-40779 NN denotes Tat
T20120 40780-40789 VB denotes inhibited
T20121 40790-40793 DT denotes the
T20122 40794-40809 JJ denotes post-activation
T20123 40810-40814 NN denotes turn
T20124 40815-40818 RP denotes off
T20125 40819-40821 IN denotes of
T20126 40822-40827 NN denotes NF-κB
T20127 40828-40830 IN denotes in
T20128 40831-40839 NN denotes presence
T20129 40840-40842 IN denotes of
T20130 40843-40848 RB denotes newly
T20131 40849-40860 VB denotes synthesized
T20132 40861-40866 NN denotes IκB-α
T20133 40868-40871 DT denotes The
T20134 40872-40885 JJ denotes Tat-dependent
T20135 40886-40896 NN denotes activation
T20136 40897-40899 IN denotes of
T20137 40900-40905 NN denotes NF-κB
T20138 40906-40916 VB denotes correlated
T20139 40917-40921 IN denotes with
T20140 40922-40925 DT denotes the
T20141 40926-40937 NN denotes association
T20142 40938-40940 IN denotes of
T20143 40941-40944 DT denotes the
T20144 40945-40950 JJ denotes viral
T20145 40951-40958 NN denotes protein
T20146 40959-40963 IN denotes with
T20147 40964-40969 NN denotes IκB-α
T20148 40969-40970 -COMMA- denotes ,
T20149 40971-40976 WDT denotes which
T20150 40977-40987 VB denotes interfered
T20151 40988-40992 IN denotes with
T20152 40993-40996 DT denotes the
T20153 40997-41007 NN denotes generation
T20154 41008-41010 IN denotes of
T20155 41011-41014 DT denotes the
T20156 41015-41024 NN denotes IκB-α/p65
T20157 41025-41032 NN denotes complex
T20158 41034-41038 DT denotes This
T20159 41039-41047 NN denotes evidence
T20160 41048-41060 VB denotes demonstrated
T20161 41061-41065 IN denotes that
T20162 41066-41069 NN denotes Tat
T20163 41070-41078 VB denotes competed
T20164 41079-41082 IN denotes for
T20165 41083-41086 DT denotes the
T20166 41087-41094 NN denotes binding
T20167 41095-41097 IN denotes of
T20168 41098-41103 NN denotes IκB-α
T20169 41104-41106 TO denotes to
T20170 41107-41110 NN denotes p65
T20171 41111-41114 CC denotes and
T20172 41115-41124 VB denotes prevented
T20173 41125-41128 DT denotes the
T20174 41129-41134 JJ denotes IκB-α
T20175 41135-41145 NN denotes repression
T20176 41146-41148 IN denotes of
T20177 41149-41152 NN denotes p65
T20178 41154-41156 IN denotes As
T20179 41157-41167 JJ denotes additional
T20180 41168-41177 NN denotes mechanism
T20181 41178-41180 IN denotes of
T20182 41181-41186 NN denotes NF-κB
T20183 41187-41197 NN denotes activation
T20184 41197-41198 -COMMA- denotes ,
T20185 41199-41202 NN denotes Tat
T20186 41203-41213 VB denotes associated
T20187 41214-41218 IN denotes with
T20188 41219-41222 NN denotes p65
T20189 41223-41226 CC denotes and
T20190 41227-41236 VB denotes increased
T20191 41237-41240 DT denotes the
T20192 41241-41244 NN denotes p65
T20193 41245-41252 NN denotes binding
T20194 41253-41261 NN denotes affinity
T20195 41262-41264 TO denotes to
T20196 41265-41268 DT denotes the
T20197 41269-41274 NN denotes NF-κB
T20198 41275-41283 NN denotes enhancer
T20199 41283-41284 -COLON- denotes ;
T20200 41285-41289 DT denotes this
T20201 41290-41298 NN denotes evidence
T20202 41299-41302 VB denotes was
T20203 41303-41311 VB denotes obtained
T20204 41312-41316 IN denotes with
T20205 41317-41328 JJ denotes recombinant
T20206 41329-41337 NN denotes proteins
T20207 41338-41348 VB denotes indicating
T20208 41349-41353 IN denotes that
T20209 41354-41357 DT denotes the
T20210 41358-41366 JJ denotes stronger
T20211 41367-41374 NN denotes binding
T20212 41375-41377 IN denotes of
T20213 41378-41381 NN denotes p65
T20214 41382-41384 TO denotes to
T20215 41385-41388 NN denotes DNA
T20216 41389-41392 VB denotes was
T20217 41393-41394 DT denotes a
T20218 41395-41406 NN denotes consequence
T20219 41407-41409 IN denotes of
T20220 41410-41416 JJ denotes direct
T20221 41417-41428 NN denotes association
T20222 41429-41433 IN denotes with
T20223 41434-41437 NN denotes Tat
T20224 41437-41438 -COMMA- denotes ,
T20225 41439-41444 WDT denotes which
T20226 41445-41451 RB denotes likely
T20227 41452-41458 VB denotes caused
T20228 41459-41460 DT denotes a
T20229 41461-41475 JJ denotes conformational
T20230 41476-41482 NN denotes change
T20231 41483-41485 IN denotes of
T20232 41486-41489 NN denotes p65
T20233 41491-41493 PRP denotes We
T20234 41494-41498 RB denotes also
T20235 41499-41511 VB denotes demonstrated
T20236 41512-41516 IN denotes that
T20237 41517-41520 DT denotes the
T20238 41521-41524 NN denotes Tat
T20239 41525-41538 JJ denotes cysteine-rich
T20240 41539-41547 NN denotes sequence
T20241 41548-41549 -LRB- denotes (
T20242 41549-41558 NN denotes C22,25,27
T20243 41558-41559 -RRB- denotes )
T20244 41560-41563 VB denotes was
T20245 41564-41572 VB denotes involved
T20246 41573-41575 IN denotes in
T20247 41576-41579 DT denotes the
T20248 41580-41587 NN denotes binding
T20249 41588-41590 TO denotes to
T20250 41591-41594 DT denotes the
T20251 41595-41598 NN denotes RHD
T20252 41599-41601 IN denotes of
T20253 41602-41605 NN denotes p65
T20254 41606-41609 CC denotes and
T20255 41610-41615 NN denotes NF-κB
T20256 41616-41626 NN denotes activation
T20257 41628-41639 RB denotes Differently
T20258 41639-41640 -COMMA- denotes ,
T20259 41641-41644 DT denotes the
T20260 41645-41648 NN denotes Tat
T20261 41649-41662 JJ denotes arginine-rich
T20262 41663-41671 NN denotes sequence
T20263 41672-41673 -LRB- denotes (
T20264 41673-41691 NN denotes R49,52,53,55,56,57
T20265 41691-41692 -RRB- denotes )
T20266 41693-41696 VB denotes was
T20267 41697-41705 VB denotes required
T20268 41706-41709 IN denotes for
T20269 41710-41713 DT denotes the
T20270 41714-41721 NN denotes binding
T20271 41722-41724 TO denotes to
T20272 41725-41728 DT denotes the
T20273 41729-41734 JJ denotes sixth
T20274 41735-41742 NN denotes ankyrin
T20275 41743-41745 IN denotes of
T20276 41746-41751 NN denotes IκB-α
T20277 41752-41753 -LRB- denotes (
T20278 41753-41758 CD denotes 50,51
T20279 41758-41759 -RRB- denotes )
T20280 41759-41760 -COMMA- denotes ,
T20281 41761-41764 CC denotes and
T20282 41765-41768 IN denotes for
T20283 41769-41778 VB denotes releasing
T20284 41779-41782 NN denotes p65
T20285 41783-41787 IN denotes from
T20286 41788-41791 DT denotes the
T20287 41792-41797 JJ denotes IκB-α
T20288 41798-41808 NN denotes inhibition
T20289 41810-41820 RB denotes Altogether
T20290 41821-41826 DT denotes these
T20291 41827-41834 NN denotes results
T20292 41835-41847 VB denotes demonstrated
T20293 41848-41852 IN denotes that
T20294 41853-41856 NN denotes Tat
T20295 41857-41866 VB denotes abolished
T20296 41867-41870 DT denotes the
T20297 41871-41879 JJ denotes negative
T20298 41880-41888 NN denotes feedback
T20299 41889-41899 NN denotes regulation
T20300 41900-41902 IN denotes of
T20301 41903-41908 NN denotes NF-κB
T20302 41909-41911 IN denotes by
T20303 41912-41921 VB denotes hijacking
T20304 41922-41925 DT denotes the
T20305 41926-41931 JJ denotes IκB-α
T20306 41932-41941 NN denotes repressor
T20307 41941-41942 -COMMA- denotes ,
T20308 41943-41952 VB denotes shielding
T20309 41953-41956 NN denotes p65
T20310 41957-41961 IN denotes from
T20311 41962-41965 DT denotes the
T20312 41966-41971 JJ denotes IκB-α
T20313 41972-41979 NN denotes embrace
T20314 41979-41980 -COMMA- denotes ,
T20315 41981-41984 CC denotes and
T20316 41985-41994 VB denotes enforcing
T20317 41995-41998 DT denotes the
T20318 41999-42002 NN denotes p65
T20319 42003-42010 NN denotes binding
T20320 42011-42013 TO denotes to
T20321 42014-42017 NN denotes DNA
T20322 42019-42026 JJ denotes Further
T20323 42027-42035 NN denotes evidence
T20324 42036-42038 IN denotes of
T20325 42039-42042 NN denotes Tat
T20326 42043-42053 NN denotes activation
T20327 42054-42056 IN denotes of
T20328 42057-42062 NN denotes NF-κB
T20329 42063-42069 VB denotes showed
T20330 42070-42074 IN denotes that
T20331 42075-42084 JJ denotes wild-type
T20332 42085-42088 NN denotes Tat
T20333 42088-42089 -COMMA- denotes ,
T20334 42090-42093 CC denotes and
T20335 42094-42097 RB denotes not
T20336 42098-42101 DT denotes the
T20337 42102-42105 NN denotes Tat
T20338 42106-42113 NN denotes mutants
T20339 42114-42121 VB denotes lacking
T20340 42122-42125 DT denotes the
T20341 42126-42135 NN denotes arginine-
T20342 42136-42138 CC denotes or
T20343 42139-42152 JJ denotes cysteine-rich
T20344 42153-42160 NN denotes domains
T20345 42160-42161 -COMMA- denotes ,
T20346 42162-42174 VB denotes up-regulated
T20347 42175-42177 FW denotes in
T20348 42178-42182 FW denotes vivo
T20349 42183-42186 DT denotes the
T20350 42187-42197 NN denotes expression
T20351 42198-42200 IN denotes of
T20352 42201-42202 DT denotes a
T20353 42203-42209 NN denotes number
T20354 42210-42212 IN denotes of
T20355 42213-42229 JJ denotes NF-κB-responsive
T20356 42230-42235 NN denotes genes
T20357 42235-42236 -COMMA- denotes ,
T20358 42237-42246 VB denotes including
T20359 42247-42253 NN denotes MIP-1α
T20360 42253-42254 -COMMA- denotes ,
T20361 42255-42259 NN denotes CSF3
T20362 42259-42260 -COMMA- denotes ,
T20363 42261-42264 NN denotes LTA
T20364 42264-42265 -COMMA- denotes ,
T20365 42266-42272 NN denotes NFKBIA
T20366 42273-42276 CC denotes and
T20367 42277-42281 NN denotes TLR2
T20368 42283-42285 IN denotes By
T20369 42286-42290 NN denotes ChIP
T20370 42291-42299 NN denotes analysis
T20371 42299-42300 -COMMA- denotes ,
T20372 42301-42303 PRP denotes we
T20373 42304-42312 VB denotes observed
T20374 42313-42317 IN denotes that
T20375 42318-42321 NN denotes Tat
T20376 42322-42331 VB denotes increased
T20377 42332-42335 DT denotes the
T20378 42336-42347 NN denotes recruitment
T20379 42348-42350 IN denotes of
T20380 42351-42354 NN denotes p65
T20381 42355-42357 TO denotes to
T20382 42358-42361 DT denotes the
T20383 42362-42367 NN denotes NF-κB
T20384 42368-42377 NN denotes enhancers
T20385 42378-42380 IN denotes of
T20386 42381-42384 DT denotes the
T20387 42385-42394 VB denotes activated
T20388 42395-42400 NN denotes genes
T20389 42400-42401 -COMMA- denotes ,
T20390 42402-42405 CC denotes and
T20391 42406-42409 VB denotes was
T20392 42410-42419 VB denotes recovered
T20393 42420-42422 IN denotes at
T20394 42423-42426 DT denotes the
T20395 42427-42431 JJ denotes same
T20396 42432-42437 NN denotes sites
T20397 42439-42442 NN denotes RNA
T20398 42443-42455 NN denotes interference
T20399 42456-42458 IN denotes of
T20400 42459-42462 NN denotes p65
T20401 42463-42472 VB denotes abolished
T20402 42473-42476 DT denotes the
T20403 42477-42480 NN denotes Tat
T20404 42481-42490 NN denotes occupancy
T20405 42491-42493 IN denotes of
T20406 42494-42497 DT denotes the
T20407 42498-42503 NN denotes NF-κB
T20408 42504-42513 NN denotes enhancers
T20409 42514-42524 VB denotes indicating
T20410 42525-42529 IN denotes that
T20411 42530-42533 DT denotes the
T20412 42534-42537 NN denotes Tat
T20413 42538-42545 NN denotes binding
T20414 42546-42548 TO denotes to
T20415 42549-42552 DT denotes the
T20416 42553-42558 NN denotes NF-κB
T20417 42559-42564 NN denotes sites
T20418 42565-42568 VB denotes was
T20419 42569-42577 VB denotes mediated
T20420 42578-42580 IN denotes by
T20421 42581-42584 NN denotes p65
T20422 42586-42591 DT denotes These
T20423 42592-42599 NN denotes results
T20424 42600-42604 VB denotes were
T20425 42605-42615 JJ denotes consistent
T20426 42616-42620 IN denotes with
T20427 42621-42624 DT denotes the
T20428 42625-42633 NN denotes evidence
T20429 42634-42638 IN denotes that
T20430 42639-42642 NN denotes Tat
T20431 42643-42652 VB denotes displaced
T20432 42653-42656 NN denotes p65
T20433 42657-42661 IN denotes from
T20434 42662-42665 DT denotes the
T20435 42666-42673 NN denotes binding
T20436 42674-42676 TO denotes to
T20437 42677-42682 NN denotes IκB-α
T20438 42683-42684 -LRB- denotes (
T20439 42684-42691 NN denotes Figures
T20440 42692-42694 NN denotes 2D
T20441 42695-42698 CC denotes and
T20442 42699-42701 NN denotes 3C
T20443 42701-42702 -RRB- denotes )
T20444 42702-42703 -COMMA- denotes ,
T20445 42704-42707 CC denotes and
T20446 42708-42717 VB denotes increased
T20447 42718-42721 DT denotes the
T20448 42722-42725 NN denotes p65
T20449 42726-42729 NN denotes DNA
T20450 42730-42737 NN denotes binding
T20451 42738-42746 NN denotes affinity
T20452 42747-42754 IN denotes through
T20453 42755-42766 NN denotes association
T20454 42767-42768 -LRB- denotes (
T20455 42768-42774 NN denotes Figure
T20456 42775-42777 NN denotes 4E
T20457 42778-42781 CC denotes and
T20458 42782-42783 NN denotes F
T20459 42783-42784 -RRB- denotes )
T20460 42786-42790 RB denotes Thus
T20461 42790-42791 -COMMA- denotes ,
T20462 42792-42795 NN denotes Tat
T20463 42796-42802 RB denotes likely
T20464 42803-42812 VB denotes increased
T20465 42813-42816 DT denotes the
T20466 42817-42828 NN denotes recruitment
T20467 42829-42831 IN denotes of
T20468 42832-42835 NN denotes p65
T20469 42836-42838 TO denotes to
T20470 42839-42842 DT denotes the
T20471 42843-42858 JJ denotes NF-κB-dependent
T20472 42859-42868 NN denotes promoters
T20473 42869-42871 IN denotes by
T20474 42872-42883 VB denotes associating
T20475 42884-42888 IN denotes with
T20476 42889-42892 NN denotes p65
T20477 42893-42896 CC denotes and
T20478 42897-42899 IN denotes by
T20479 42900-42911 VB denotes interfering
T20480 42912-42916 IN denotes with
T20481 42917-42920 DT denotes the
T20482 42921-42929 NN denotes assembly
T20483 42930-42932 IN denotes of
T20484 42933-42936 NN denotes p65
T20485 42937-42941 IN denotes with
T20486 42942-42945 DT denotes the
T20487 42946-42955 NN denotes repressor
T20488 42956-42961 NN denotes IκB-α
T20489 42963-42965 IN denotes Of
T20490 42966-42974 NN denotes interest
T20491 42974-42975 -COMMA- denotes ,
T20492 42976-42981 NN denotes IκB-α
T20493 42982-42985 VB denotes was
T20494 42986-42991 VB denotes found
T20495 42992-43002 VB denotes associated
T20496 43003-43005 TO denotes to
T20497 43006-43009 DT denotes the
T20498 43010-43015 NN denotes NF-κB
T20499 43016-43025 NN denotes enhancers
T20500 43026-43028 IN denotes in
T20501 43029-43036 NN denotes absence
T20502 43037-43039 IN denotes of
T20503 43040-43043 NN denotes Tat
T20504 43043-43044 -COMMA- denotes ,
T20505 43045-43050 WRB denotes where
T20506 43051-43053 PRP denotes it
T20507 43054-43057 VB denotes was
T20508 43058-43067 VB denotes displaced
T20509 43068-43070 IN denotes in
T20510 43071-43079 NN denotes presence
T20511 43080-43082 IN denotes of
T20512 43083-43087 NNP denotes Tat.
T20513 43088-43093 DT denotes These
T20514 43094-43101 NN denotes results
T20515 43102-43109 VB denotes suggest
T20516 43110-43111 DT denotes a
T20517 43112-43120 JJ denotes negative
T20518 43121-43131 JJ denotes regulatory
T20519 43132-43136 NN denotes role
T20520 43137-43139 IN denotes of
T20521 43140-43145 NN denotes IκB-α
T20522 43146-43148 IN denotes in
T20523 43149-43153 NN denotes gene
T20524 43154-43164 NN denotes regulation
T20525 43165-43172 IN denotes through
T20526 43173-43182 NN denotes occupancy
T20527 43183-43185 IN denotes of
T20528 43186-43194 JJ denotes specific
T20529 43195-43204 NN denotes promoters
T20530 43206-43212 RB denotes Indeed
T20531 43212-43213 -COMMA- denotes ,
T20532 43214-43219 NN denotes IκB-α
T20533 43220-43223 VB denotes was
T20534 43224-43229 VB denotes found
T20535 43230-43240 VB denotes associated
T20536 43241-43245 IN denotes with
T20537 43246-43253 NN denotes hystone
T20538 43254-43266 NN denotes deacetylases
T20539 43267-43269 IN denotes at
T20540 43270-43273 DT denotes the
T20541 43274-43278 NN denotes hes1
T20542 43279-43287 NN denotes promoter
T20543 43287-43288 -COMMA- denotes ,
T20544 43289-43293 IN denotes from
T20545 43294-43299 WRB denotes where
T20546 43300-43302 PRP denotes it
T20547 43303-43306 VB denotes was
T20548 43307-43314 VB denotes removed
T20549 43315-43324 VB denotes following
T20550 43325-43330 NN denotes TNF-α
T20551 43331-43342 NN denotes stimulation
T20552 43343-43350 VB denotes causing
T20553 43351-43358 NN denotes histone
T20554 43359-43370 NN denotes acetylation
T20555 43371-43374 CC denotes and
T20556 43375-43379 NN denotes hes1
T20557 43380-43395 JJ denotes transcriptional
T20558 43396-43406 NN denotes activation
T20559 43407-43408 -LRB- denotes (
T20560 43408-43410 CD denotes 65
T20561 43410-43411 -RRB- denotes )
T20562 43413-43414 DT denotes A
T20563 43415-43422 JJ denotes similar
T20564 43423-43432 NN denotes mechanism
T20565 43433-43435 IN denotes of
T20566 43436-43440 NN denotes gene
T20567 43441-43451 NN denotes regulation
T20568 43452-43457 MD denotes could
T20569 43458-43463 VB denotes apply
T20570 43464-43466 TO denotes to
T20571 43467-43470 DT denotes the
T20572 43471-43486 JJ denotes NF-κB-dependent
T20573 43487-43492 NN denotes genes
T20574 43493-43501 VB denotes analysed
T20575 43502-43504 IN denotes in
T20576 43505-43509 DT denotes this
T20577 43510-43515 NN denotes study
T20578 43515-43516 -COMMA- denotes ,
T20579 43517-43522 WRB denotes where
T20580 43523-43526 NN denotes Tat
T20581 43527-43532 MD denotes could
T20582 43533-43541 VB denotes activate
T20583 43542-43545 DT denotes the
T20584 43546-43550 NN denotes gene
T20585 43551-43561 NN denotes expression
T20586 43562-43564 IN denotes by
T20587 43565-43573 VB denotes removing
T20588 43574-43579 NN denotes IκB-α
T20589 43580-43583 CC denotes and
T20590 43584-43593 VB denotes promoting
T20591 43594-43597 DT denotes the
T20592 43598-43601 NN denotes p65
T20593 43602-43609 NN denotes loading
T20594 43610-43611 -LRB- denotes (
T20595 43611-43617 NN denotes Figure
T20596 43618-43619 CD denotes 7
T20597 43619-43620 -RRB- denotes )
T20598 44045-44048 DT denotes The
T20599 44049-44062 JJ denotes physiological
T20600 44063-44072 NN denotes relevance
T20601 44073-44075 IN denotes of
T20602 44076-44079 NN denotes Tat
T20603 44080-44085 RB denotes cross
T20604 44086-44090 NN denotes talk
T20605 44091-44095 IN denotes with
T20606 44096-44101 NN denotes NF-κB
T20607 44102-44105 VB denotes was
T20608 44106-44118 VB denotes demonstrated
T20609 44119-44121 IN denotes in
T20610 44122-44125 DT denotes the
T20611 44126-44131 NN denotes HIV-1
T20612 44132-44141 NN denotes infection
T20613 44142-44144 IN denotes of
T20614 44145-44150 JJ denotes human
T20615 44151-44160 NN denotes monocytes
T20616 44160-44161 -COMMA- denotes ,
T20617 44162-44167 WRB denotes where
T20618 44168-44181 JJ denotes HIV-1-encoded
T20619 44182-44185 NN denotes Tat
T20620 44186-44193 NN denotes protein
T20621 44194-44206 VB denotes counteracted
T20622 44207-44222 JJ denotes post-activation
T20623 44223-44227 NN denotes turn
T20624 44228-44231 RP denotes off
T20625 44232-44234 IN denotes of
T20626 44235-44240 NN denotes NF-κB
T20627 44240-44241 -COMMA- denotes ,
T20628 44242-44244 IN denotes as
T20629 44245-44250 VB denotes shown
T20630 44251-44253 IN denotes by
T20631 44253-44254 -COLON- denotes :
T20632 44255-44256 -LRB- denotes (
T20633 44256-44257 LS denotes i
T20634 44257-44258 -RRB- denotes )
T20635 44259-44268 VB denotes sustained
T20636 44269-44274 NN denotes NF-κB
T20637 44275-44283 NN denotes activity
T20638 44284-44286 IN denotes by
T20639 44287-44290 NN denotes Tat
T20640 44291-44293 IN denotes in
T20641 44294-44302 NN denotes presence
T20642 44303-44305 IN denotes of
T20643 44306-44311 RB denotes newly
T20644 44312-44323 VB denotes synthesized
T20645 44324-44329 NN denotes IκB-α
T20646 44329-44330 -COLON- denotes ;
T20647 44331-44332 -LRB- denotes (
T20648 44332-44334 LS denotes ii
T20649 44334-44335 -RRB- denotes )
T20650 44336-44357 NN denotes coimmunoprecipitation
T20651 44358-44360 IN denotes of
T20652 44361-44364 NN denotes Tat
T20653 44365-44369 IN denotes with
T20654 44370-44375 NN denotes IκB-α
T20655 44376-44379 CC denotes and
T20656 44380-44383 NN denotes p65
T20657 44383-44384 -COLON- denotes ;
T20658 44385-44386 -LRB- denotes (
T20659 44386-44389 LS denotes iii
T20660 44389-44390 -RRB- denotes )
T20661 44391-44400 NN denotes induction
T20662 44401-44403 IN denotes of
T20663 44404-44410 NN denotes MIP-1α
T20664 44411-44421 NN denotes expression
T20665 44422-44431 JJ denotes dependent
T20666 44432-44434 IN denotes on
T20667 44435-44438 NN denotes Tat
T20668 44439-44442 CC denotes and
T20669 44443-44446 NN denotes p65
T20670 44446-44447 -COLON- denotes ;
T20671 44448-44449 -LRB- denotes (
T20672 44449-44451 LS denotes iv
T20673 44451-44452 -RRB- denotes )
T20674 44453-44456 NN denotes Tat
T20675 44457-44466 NN denotes occupancy
T20676 44467-44469 IN denotes of
T20677 44470-44473 DT denotes the
T20678 44474-44480 NN denotes MIP-1α
T20679 44481-44486 NN denotes NF-κB
T20680 44487-44495 NN denotes enhancer
T20681 44496-44506 VB denotes associated
T20682 44507-44511 IN denotes with
T20683 44512-44521 VB denotes increased
T20684 44522-44533 NN denotes recruitment
T20685 44534-44536 IN denotes of
T20686 44537-44540 NN denotes p65
T20687 44542-44546 DT denotes This
T20688 44547-44552 NN denotes study
T20689 44553-44561 VB denotes supports
T20690 44562-44565 DT denotes the
T20691 44566-44582 JJ denotes pro-inflammatory
T20692 44583-44589 NN denotes action
T20693 44590-44592 IN denotes of
T20694 44593-44596 NN denotes Tat
T20695 44597-44604 IN denotes through
T20696 44605-44613 JJ denotes physical
T20697 44614-44625 NN denotes interaction
T20698 44626-44630 IN denotes with
T20699 44631-44634 NN denotes p65
T20700 44635-44638 CC denotes and
T20701 44639-44644 NN denotes IκB-α
T20702 44646-44653 JJ denotes Several
T20703 44654-44666 JJ denotes inflammatory
T20704 44667-44676 NN denotes cytokines
T20705 44677-44682 IN denotes under
T20706 44683-44686 DT denotes the
T20707 44687-44702 JJ denotes transcriptional
T20708 44703-44710 NN denotes control
T20709 44711-44713 IN denotes of
T20710 44714-44719 NN denotes NF-κB
T20711 44720-44723 VB denotes are
T20712 44724-44739 JJ denotes hyper-expressed
T20713 44740-44742 IN denotes in
T20714 44743-44748 NN denotes HIV-1
T20715 44749-44757 JJ denotes infected
T20716 44758-44769 NN denotes individuals
T20717 44769-44770 -COMMA- denotes ,
T20718 44771-44780 VB denotes including
T20719 44781-44785 NN denotes IL-6
T20720 44786-44787 -LRB- denotes (
T20721 44787-44792 CD denotes 66,67
T20722 44792-44793 -RRB- denotes )
T20723 44793-44794 -COMMA- denotes ,
T20724 44795-44800 NN denotes TNF-α
T20725 44801-44802 -LRB- denotes (
T20726 44802-44804 CD denotes 68
T20727 44804-44805 -RRB- denotes )
T20728 44805-44806 -COMMA- denotes ,
T20729 44807-44810 CC denotes and
T20730 44811-44817 NN denotes MIP-1α
T20731 44818-44819 -LRB- denotes (
T20732 44819-44830 CD denotes 57–62,69–71
T20733 44830-44831 -RRB- denotes )
T20734 44833-44835 IN denotes In
T20735 44836-44839 DT denotes the
T20736 44840-44844 NN denotes case
T20737 44845-44847 IN denotes of
T20738 44848-44853 NN denotes TNF-α
T20739 44854-44857 CC denotes and
T20740 44858-44862 NN denotes IL-6
T20741 44862-44863 -COMMA- denotes ,
T20742 44864-44867 NN denotes Tat
T20743 44868-44877 VB denotes activated
T20744 44878-44881 DT denotes the
T20745 44882-44890 NN denotes cytokine
T20746 44891-44901 NN denotes expression
T20747 44902-44904 IN denotes by
T20748 44905-44912 VB denotes binding
T20749 44913-44915 TO denotes to
T20750 44916-44919 DT denotes the
T20751 44920-44928 JJ denotes TAR-like
T20752 44929-44933 NN denotes stem
T20753 44934-44938 NN denotes loop
T20754 44939-44941 IN denotes of
T20755 44942-44945 DT denotes the
T20756 44946-44948 NN denotes 5′
T20757 44949-44959 NN denotes transcript
T20758 44959-44960 -COMMA- denotes ,
T20759 44961-44965 RB denotes thus
T20760 44966-44972 RB denotes likely
T20761 44973-44982 VB denotes promoting
T20762 44983-44986 DT denotes the
T20763 44987-45002 JJ denotes transcriptional
T20764 45003-45013 NN denotes elongation
T20765 45014-45015 -LRB- denotes (
T20766 45015-45023 CD denotes 33,37,47
T20767 45023-45024 -RRB- denotes )
T20768 45026-45030 RB denotes Here
T20769 45030-45031 -COMMA- denotes ,
T20770 45032-45034 PRP denotes we
T20771 45035-45039 VB denotes have
T20772 45040-45045 VB denotes shown
T20773 45046-45050 IN denotes that
T20774 45051-45054 DT denotes the
T20775 45055-45068 JJ denotes Tat-dependent
T20776 45069-45084 JJ denotes transcriptional
T20777 45085-45095 NN denotes activation
T20778 45096-45098 IN denotes of
T20779 45099-45100 DT denotes a
T20780 45101-45107 NN denotes number
T20781 45108-45110 IN denotes of
T20782 45111-45127 JJ denotes pro-inflammatory
T20783 45128-45133 NN denotes genes
T20784 45134-45142 VB denotes required
T20785 45143-45146 DT denotes the
T20786 45147-45155 NN denotes assembly
T20787 45156-45158 IN denotes of
T20788 45159-45162 NN denotes Tat
T20789 45163-45167 IN denotes with
T20790 45168-45171 NN denotes p65
T20791 45172-45174 IN denotes at
T20792 45175-45178 DT denotes the
T20793 45179-45184 NN denotes NF-κB
T20794 45185-45193 NN denotes enhancer
T20795 45194-45202 RB denotes together
T20796 45203-45207 IN denotes with
T20797 45208-45211 DT denotes the
T20798 45212-45224 NN denotes displacement
T20799 45225-45227 IN denotes of
T20800 45228-45233 NN denotes IκB-α
T20801 45234-45235 -LRB- denotes (
T20802 45235-45241 NN denotes Figure
T20803 45242-45243 CD denotes 5
T20804 45243-45244 -RRB- denotes )
T20805 45246-45250 RB denotes Thus
T20806 45250-45251 -COMMA- denotes ,
T20807 45252-45254 IN denotes in
T20808 45255-45258 DT denotes the
T20809 45259-45262 NN denotes set
T20810 45263-45265 IN denotes of
T20811 45266-45274 JJ denotes distinct
T20812 45275-45291 JJ denotes NF-κB-responsive
T20813 45292-45297 NN denotes genes
T20814 45297-45298 -COMMA- denotes ,
T20815 45299-45302 NN denotes Tat
T20816 45303-45308 VB denotes acted
T20817 45309-45311 IN denotes as
T20818 45312-45313 DT denotes a
T20819 45314-45323 NN denotes component
T20820 45324-45326 IN denotes of
T20821 45327-45330 DT denotes the
T20822 45331-45346 JJ denotes transcriptional
T20823 45347-45357 NN denotes initiation
T20824 45358-45365 NN denotes complex
T20825 45365-45366 -COMMA- denotes ,
T20826 45367-45372 WDT denotes which
T20827 45373-45375 VB denotes is
T20828 45376-45386 JJ denotes consistent
T20829 45387-45391 IN denotes with
T20830 45392-45400 JJ denotes previous
T20831 45401-45408 NN denotes reports
T20832 45409-45411 IN denotes on
T20833 45412-45415 NN denotes Tat
T20834 45416-45425 VB denotes promoting
T20835 45426-45429 DT denotes the
T20836 45430-45443 NN denotes transcription
T20837 45444-45447 IN denotes via
T20838 45448-45451 NN denotes DNA
T20839 45452-45458 NN denotes motifs
T20840 45459-45460 -LRB- denotes (
T20841 45460-45465 CD denotes 72,73
T20842 45465-45466 -RRB- denotes )
T20843 45468-45482 NN denotes Overproduction
T20844 45483-45485 IN denotes of
T20845 45486-45502 JJ denotes pro-inflammatory
T20846 45503-45512 NN denotes cytokines
T20847 45513-45515 VB denotes is
T20848 45516-45526 VB denotes considered
T20849 45527-45528 DT denotes a
T20850 45529-45534 JJ denotes major
T20851 45535-45544 NN denotes mechanism
T20852 45545-45547 IN denotes of
T20853 45548-45554 JJ denotes immune
T20854 45555-45567 NN denotes deregulation
T20855 45568-45569 -LRB- denotes (
T20856 45569-45571 CD denotes 26
T20857 45571-45572 -RRB- denotes )
T20858 45573-45576 CC denotes and
T20859 45577-45583 NN denotes neuron
T20860 45584-45595 NN denotes dysfunction
T20861 45596-45598 IN denotes in
T20862 45599-45603 NN denotes AIDS
T20863 45604-45605 -LRB- denotes (
T20864 45605-45610 CD denotes 74,75
T20865 45610-45611 -RRB- denotes )
T20866 45613-45615 IN denotes In
T20867 45616-45620 DT denotes this
T20868 45621-45629 NN denotes scenario
T20869 45629-45630 -COMMA- denotes ,
T20870 45631-45641 NN denotes inhibition
T20871 45642-45644 IN denotes of
T20872 45645-45650 NN denotes NF-κB
T20873 45651-45659 NN denotes activity
T20874 45660-45665 MD denotes could
T20875 45666-45670 VB denotes lead
T20876 45671-45673 TO denotes to
T20877 45674-45675 DT denotes a
T20878 45676-45687 JJ denotes therapeutic
T20879 45688-45696 NN denotes strategy
T20880 45697-45700 IN denotes for
T20881 45701-45714 VB denotes counteracting
T20882 45715-45718 DT denotes the
T20883 45719-45727 JJ denotes abnormal
T20884 45728-45738 NN denotes production
T20885 45739-45741 IN denotes of
T20886 45742-45758 JJ denotes pro-inflammatory
T20887 45759-45768 NN denotes cytokines
T20888 45769-45772 CC denotes and
T20889 45773-45783 NN denotes chemokines
T20890 45784-45786 IN denotes in
T20891 45787-45792 NN denotes HIV-1
T20892 45793-45802 NN denotes infection
T20893 45804-45809 NN denotes NF-κB
T20894 45810-45820 NN denotes inhibitors
T20895 45820-45821 -COMMA- denotes ,
T20896 45822-45826 JJ denotes such
T20897 45827-45829 IN denotes as
T20898 45830-45843 NN denotes anti-oxidants
T20899 45843-45844 -COMMA- denotes ,
T20900 45845-45855 NN denotes proteasome
T20901 45856-45859 CC denotes and
T20902 45860-45863 NN denotes IKK
T20903 45864-45874 NN denotes inhibitors
T20904 45874-45875 -COMMA- denotes ,
T20905 45876-45889 RB denotes significantly
T20906 45890-45897 VB denotes reduced
T20907 45898-45901 DT denotes the
T20908 45902-45907 NN denotes HIV-1
T20909 45908-45919 NN denotes replication
T20910 45920-45923 CC denotes and
T20911 45924-45927 DT denotes the
T20912 45928-45938 VB denotes associated
T20913 45939-45951 JJ denotes inflammatory
T20914 45952-45960 NN denotes response
T20915 45961-45962 -LRB- denotes (
T20916 45962-45967 CD denotes 76,77
T20917 45967-45968 -RRB- denotes )
T20918 45968-45969 -COLON- denotes ;
T20919 45970-45977 RB denotes however
T20920 45977-45978 -COMMA- denotes ,
T20921 45979-45984 DT denotes these
T20922 45985-45990 NN denotes NF-κB
T20923 45991-46001 NN denotes inhibitors
T20924 46002-46007 VB denotes acted
T20925 46008-46024 RB denotes indiscriminately
T20926 46025-46027 IN denotes in
T20927 46028-46032 CC denotes both
T20928 46033-46047 JJ denotes HIV-1-infected
T20929 46048-46051 CC denotes and
T20930 46052-46062 JJ denotes uninfected
T20931 46063-46068 NN denotes cells
T20932 46070-46073 DT denotes The
T20933 46074-46082 NN denotes evidence
T20934 46083-46087 IN denotes that
T20935 46088-46091 NN denotes Tat
T20936 46092-46101 VB denotes activates
T20937 46102-46107 NN denotes NF-κB
T20938 46108-46115 IN denotes through
T20939 46116-46122 JJ denotes direct
T20940 46123-46134 NN denotes interaction
T20941 46135-46139 IN denotes with
T20942 46140-46145 NN denotes IκB-α
T20943 46146-46149 CC denotes and
T20944 46150-46153 NN denotes p65
T20945 46154-46157 MD denotes may
T20946 46158-46162 VB denotes lead
T20947 46163-46165 TO denotes to
T20948 46166-46174 JJ denotes specific
T20949 46175-46185 NN denotes inhibitors
T20950 46186-46188 TO denotes to
T20951 46189-46199 VB denotes counteract
T20952 46200-46203 DT denotes the
T20953 46204-46207 NN denotes Tat
T20954 46208-46224 JJ denotes pro-inflammatory
T20955 46225-46231 NN denotes action
T24359 20207-20210 NN denotes Tat
T24360 20211-20219 VB denotes enhances
T24361 20220-20223 DT denotes the
T24362 20224-20229 NN denotes NF-κB
T24363 20230-20238 NN denotes activity
T24364 20239-20248 VB denotes following
T24365 20249-20252 NN denotes PMA
T24366 20253-20264 NN denotes stimulation
T24367 20265-20267 IN denotes by
T24368 20268-20279 VB denotes associating
T24369 20280-20284 IN denotes with
T24370 20285-20290 NN denotes IκB-α
T24371 20291-20294 CC denotes and
T24372 20295-20308 VB denotes counteracting
T24373 20309-20312 DT denotes the
T24374 20313-20318 NN denotes NF-κB
T24375 20319-20329 NN denotes repression
T24376 20331-20335 NN denotes HeLa
T24377 20336-20341 NN denotes cells
T24378 20342-20343 -LRB- denotes (
T24379 20343-20350 CD denotes 5 × 106
T24380 20350-20351 -RRB- denotes )
T24381 20352-20356 VB denotes were
T24382 20357-20368 VB denotes transfected
T24383 20369-20373 IN denotes with
T24384 20374-20385 NN denotes p3xFLAG-Tat
T24385 20386-20388 CC denotes or
T24386 20389-20396 NN denotes p3xFLAG
T24387 20397-20402 NN denotes empty
T24388 20403-20409 NN denotes vector
T24389 20410-20411 -LRB- denotes (
T24390 20411-20415 NN denotes 5 µg
T24391 20415-20416 -RRB- denotes )
T24392 20416-20417 -COMMA- denotes ,
T24393 20418-20421 CC denotes and
T24394 20422-20426 NN denotes 48 h
T24395 20427-20432 RB denotes later
T24396 20433-20437 VB denotes were
T24397 20438-20448 VB denotes stimulated
T24398 20449-20453 IN denotes with
T24399 20454-20457 NN denotes PMA
T24400 20458-20459 -LRB- denotes (
T24401 20459-20464 NN denotes 5 min
T24402 20464-20465 -COMMA- denotes ,
T24403 20466-20474 NN denotes 20 ng/ml
T24404 20474-20475 -RRB- denotes )
T24405 20476-20478 CC denotes or
T24406 20479-20483 VB denotes left
T24407 20484-20496 JJ denotes unstimulated
T24408 20496-20497 -COMMA- denotes ,
T24409 20498-20504 VB denotes washed
T24410 20505-20510 RB denotes twice
T24411 20511-20515 IN denotes with
T24412 20516-20520 NN denotes DMEM
T24413 20521-20524 CC denotes and
T24414 20525-20534 VB denotes harvested
T24415 20535-20537 IN denotes at
T24416 20538-20541 DT denotes the
T24417 20542-20551 JJ denotes indicated
T24418 20552-20557 NN denotes times
T24419 20559-20566 JJ denotes Nuclear
T24420 20567-20570 CC denotes and
T24421 20571-20580 JJ denotes cytosolic
T24422 20581-20589 NN denotes extracts
T24423 20590-20594 VB denotes were
T24424 20595-20603 VB denotes prepared
T24425 20604-20607 IN denotes for
T24426 20608-20615 JJ denotes further
T24427 20616-20625 NN denotes analysis.
T24428 20626-20627 -LRB- denotes (
T24429 20627-20628 NN denotes A
T24430 20628-20629 -RRB- denotes )
T24431 20630-20637 JJ denotes Nuclear
T24432 20638-20646 NN denotes extracts
T24433 20647-20651 VB denotes were
T24434 20652-20660 VB denotes analysed
T24435 20661-20664 IN denotes for
T24436 20665-20668 DT denotes the
T24437 20669-20672 NN denotes p65
T24438 20672-20673 -COMMA- denotes ,
T24439 20674-20677 NN denotes p50
T24440 20678-20681 CC denotes and
T24441 20682-20690 NN denotes FLAG-Tat
T24442 20691-20698 NN denotes binding
T24443 20699-20701 TO denotes to
T24444 20702-20705 DT denotes the
T24445 20706-20711 NN denotes NF-κB
T24446 20712-20727 JJ denotes double-stranded
T24447 20728-20743 NN denotes oligonucleotide
T24448 20744-20749 VB denotes using
T24449 20750-20753 DT denotes the
T24450 20754-20759 NN denotes NF-κB
T24451 20760-20773 NN denotes Transcription
T24452 20774-20780 NN denotes Factor
T24453 20781-20786 NN denotes ELISA
T24454 20787-20792 NN denotes assay
T24455 20793-20796 NN denotes kit
T24456 20797-20798 -LRB- denotes (
T24457 20798-20804 NN denotes Cayman
T24458 20804-20805 -RRB- denotes )
T24459 20805-20806 -LRB- denotes .
T24460 20807-20808 NN denotes (
T24461 20808-20809 -RRB- denotes B
T24462 20809-20816 JJ denotes ) Nucle
T24463 20816-20819 CC denotes ar
T24464 20819-20828 JJ denotes and cytos
T24465 20828-20836 NN denotes olic ext
T24466 20836-20837 -LRB- denotes r
T24467 20837-20842 NN denotes acts
T24468 20842-20843 -RRB- denotes (
T24469 20843-20847 VB denotes 20 µ
T24470 20847-20856 VB denotes g) were s
T24471 20856-20858 IN denotes ep
T24472 20858-20860 CD denotes ar
T24473 20860-20861 NN denotes a
T24474 20861-20869 NN denotes ted by 1
T24475 20869-20872 CC denotes 2%
T24476 20872-20880 VB denotes SDS–PAGE
T24477 20881-20883 IN denotes an
T24478 20883-20890 JJ denotes d analy
T24479 20890-20898 NN denotes sed by w
T24480 20898-20903 VB denotes ester
T24481 20903-20906 DT denotes n b
T24482 20906-20914 JJ denotes lotting
T24483 20914-20915 -COMMA- denotes u
T24484 20915-20924 JJ denotes sing the
T24485 20924-20925 -COMMA- denotes a
T24486 20925-20937 JJ denotes nti-p65, ant
T24487 20937-20939 NN denotes i-
T24488 20939-20940 -COMMA- denotes F
T24489 20940-20950 JJ denotes LAG, anti-
T24490 20950-20953 CC denotes His
T24491 20953-20971 JJ denotes tone H1, anti-IκB-
T24492 20971-20981 NN denotes α and anti
T24493 21008-21020 NN denotes Densitometry
T24494 21021-21027 NN denotes values
T24495 21028-21029 -LRB- denotes (
T24496 21029-21030 NN denotes D
T24497 21030-21031 -RRB- denotes )
T24498 21032-21034 IN denotes of
T24499 21035-21038 DT denotes the
T24500 21039-21044 NN denotes bands
T24501 21045-21049 VB denotes were
T24502 21050-21059 VB denotes expressed
T24503 21060-21062 IN denotes as
T24504 21063-21067 JJ denotes fold
T24505 21068-21076 NN denotes increase
T24506 21077-21082 IN denotes above
T24507 21083-21086 DT denotes the
T24508 21087-21094 NN denotes control
T24509 21095-21096 -LRB- denotes (
T24510 21096-21100 NN denotes lane
T24511 21101-21102 CD denotes 1
T24512 21102-21103 -RRB- denotes )
T24513 21103-21104 -LRB- denotes .
T24514 21105-21106 NN denotes (
T24515 21106-21107 -RRB- denotes C
T24516 21107-21110 NN denotes ) I
T24517 21110-21118 NN denotes KK activ
T24518 21118-21121 VB denotes ity
T24519 21122-21130 VB denotes was meas
T24520 21130-21132 IN denotes ur
T24521 21132-21141 JJ denotes ed in cyt
T24522 21141-21149 NN denotes osolic e
T24523 21149-21150 -LRB- denotes x
T24524 21150-21156 NN denotes tracts
T24525 21157-21158 -RRB- denotes (
T24526 21158-21160 IN denotes 10
T24527 21160-21165 VB denotes 0 µg)
T24528 21166-21172 NN denotes by usi
T24529 21172-21175 NN denotes ng
T24530 21175-21181 NN denotes HTScan
T24531 21182-21187 NN denotes IKK k
T24532 21187-21188 -LRB- denotes i
T24533 21188-21192 NNP denotes nase
T24534 21193-21202 NNP denotes assay (Ce
T24535 21202-21212 NNP denotes ll Signali
T24536 21212-21213 -RRB- denotes n
T24537 21213-21214 -LRB- denotes g
T24538 21215-21216 NN denotes T
T24539 21216-21217 -RRB- denotes e
T24540 21217-21221 NN denotes chno
T24541 21221-21226 NN denotes logy)
T24542 21226-21227 -LRB- denotes .
T24543 21228-21235 CD denotes (D) HeL
T24544 21235-21236 -RRB- denotes a
T24545 21237-21241 VB denotes cell
T24546 21241-21252 VB denotes s (5 × 106)
T24547 21253-21257 IN denotes were
T24548 21258-21260 CC denotes tr
T24549 21260-21267 IN denotes ansfect
T24550 21267-21278 NN denotes ed with or
T24551 21278-21279 -LRB- denotes w
T24552 21279-21283 NN denotes itho
T24553 21283-21284 -RRB- denotes u
T24554 21284-21285 -COLON- denotes t
T24555 21286-21290 NN denotes p3xF
T24556 21290-21295 RB denotes LAG-T
T24557 21295-21296 -COMMA- denotes a
T24558 21296-21301 NN denotes t (5 
T24559 21301-21305 VB denotes µg);
T24560 21306-21316 VB denotes 48 h later
T24561 21316-21320 IN denotes , ce
T24562 21320-21323 NN denotes lls
T24563 21324-21325 -LRB- denotes w
T24564 21325-21330 NN denotes ere s
T24565 21330-21331 -COMMA- denotes t
T24566 21331-21339 NN denotes imulated
T24567 21340-21341 -RRB- denotes w
T24568 21341-21343 CC denotes it
T24569 21343-21347 VB denotes h PM
T24570 21347-21359 JJ denotes A (5 min, 20
T24571 21359-21360 -COMMA- denotes  
T24572 21360-21366 VB denotes ng/ml)
T24573 21367-21372 RB denotes or le
T24574 21372-21376 IN denotes ft u
T24575 21376-21380 NN denotes nsti
T24576 21380-21381 -COMMA- denotes m
T24577 21381-21384 CC denotes ula
T24578 21384-21393 VB denotes ted, wash
T24579 21393-21398 IN denotes ed tw
T24580 21398-21405 NN denotes ice wit
T24581 21442-21447 JJ denotes Whole
T24582 21448-21452 NN denotes cell
T24583 21453-21461 NN denotes extracts
T24584 21462-21463 -LRB- denotes (
T24585 21463-21467 NN denotes 1 mg
T24586 21467-21468 -RRB- denotes )
T24587 21469-21473 VB denotes were
T24588 21474-21492 VB denotes immunoprecipitated
T24589 21493-21497 IN denotes with
T24590 21498-21505 NN denotes protein
T24591 21506-21525 JJ denotes G-Sepharose-coupled
T24592 21526-21536 JJ denotes anti-IκB-α
T24593 21537-21545 NN denotes antibody
T24594 21547-21562 NN denotes Immunocomplexes
T24595 21563-21567 VB denotes were
T24596 21568-21577 VB denotes separated
T24597 21578-21580 IN denotes by
T24598 21581-21583 CD denotes 12
T24599 21583-21584 NN denotes %
T24600 21585-21593 NN denotes SDS–PAGE
T24601 21594-21597 CC denotes and
T24602 21598-21606 VB denotes analysed
T24603 21607-21609 IN denotes by
T24604 21610-21617 JJ denotes western
T24605 21618-21626 NN denotes blotting
T24606 21627-21631 IN denotes with
T24607 21632-21640 JJ denotes anti-p65
T24608 21640-21641 -COMMA- denotes ,
T24609 21642-21651 JJ denotes anti-FLAG
T24610 21652-21655 CC denotes and
T24611 21656-21666 JJ denotes anti-IκB-α
T24612 21667-21677 NN denotes antibodies
T24613 21679-21691 NN denotes Densitometry
T24614 21692-21698 NN denotes values
T24615 21699-21700 -LRB- denotes (
T24616 21700-21701 NN denotes D
T24617 21701-21702 -RRB- denotes )
T24618 21703-21705 IN denotes of
T24619 21706-21709 DT denotes the
T24620 21710-21715 NN denotes bands
T24621 21716-21720 VB denotes were
T24622 21721-21730 VB denotes expressed
T24623 21731-21733 IN denotes as
T24624 21734-21738 JJ denotes fold
T24625 21739-21747 NN denotes increase
T24626 21748-21753 IN denotes above
T24627 21754-21757 DT denotes the
T24628 21758-21765 NN denotes control
T24629 21766-21767 -LRB- denotes (
T24630 21767-21771 NN denotes lane
T24631 21772-21773 CD denotes 1
T24632 21773-21774 -RRB- denotes )
T24633 21776-21782 NN denotes Values
T24634 21783-21784 -LRB- denotes (
T24635 21784-21793 NN denotes mean ± SE
T24636 21793-21794 -COMMA- denotes ,
T24637 21795-21800 NN denotes n = 3
T24638 21800-21801 -RRB- denotes )
T24639 21802-21805 VB denotes are
T24640 21806-21811 VB denotes shown
T25214 23400-23403 NN denotes Tat
T25215 23404-23412 VB denotes relieves
T25216 23413-23416 NN denotes p65
T25217 23417-23421 IN denotes from
T25218 23422-23425 DT denotes the
T25219 23426-23431 JJ denotes IκB-α
T25220 23432-23443 NN denotes inhibition.
T25221 23444-23445 -LRB- denotes (
T25222 23445-23446 NN denotes A
T25223 23446-23447 -RRB- denotes )
T25224 23448-23457 JJ denotes Schematic
T25225 23458-23472 NN denotes representation
T25226 23473-23475 IN denotes of
T25227 23476-23485 JJ denotes wild-type
T25228 23486-23489 CC denotes and
T25229 23490-23496 JJ denotes mutant
T25230 23497-23500 NN denotes Tat
T25231 23501-23510 NN denotes proteins.
T25232 23511-23512 -LRB- denotes (
T25233 23512-23513 NN denotes B
T25234 23513-23514 -RRB- denotes )
T25235 23515-23523 NN denotes HA-IκB-α
T25236 23524-23525 -LRB- denotes (
T25237 23525-23529 NN denotes 5 µl
T25238 23529-23530 -RRB- denotes )
T25239 23531-23534 VB denotes was
T25240 23535-23544 VB denotes incubated
T25241 23545-23547 IN denotes in
T25242 23548-23556 NN denotes presence
T25243 23557-23559 CC denotes or
T25244 23560-23567 NN denotes absence
T25245 23568-23570 IN denotes of
T25246 23571-23579 NN denotes FLAG-Tat
T25247 23579-23580 -COMMA- denotes ,
T25248 23581-23589 NN denotes FLAG-Tat
T25249 23590-23591 NNP denotes T
T25250 23591-23592 -COMMA- denotes ,
T25251 23592-23593 NN denotes N
T25252 23593-23594 -LRB- denotes (
T25253 23594-23599 CD denotes 23,24
T25254 23599-23600 -RRB- denotes )
T25255 23600-23601 NN denotes A
T25256 23601-23602 -COMMA- denotes ,
T25257 23603-23611 NN denotes FLAG-Tat
T25258 23612-23613 NN denotes K
T25259 23613-23614 -LRB- denotes (
T25260 23614-23619 CD denotes 50,51
T25261 23619-23620 -RRB- denotes )
T25262 23620-23621 NN denotes A
T25263 23621-23622 -COMMA- denotes ,
T25264 23623-23631 NN denotes FLAG-Tat
T25265 23632-23633 NN denotes R
T25266 23633-23634 -LRB- denotes (
T25267 23634-23639 CD denotes 49–57
T25268 23639-23640 -RRB- denotes )
T25269 23640-23641 NN denotes A
T25270 23642-23644 CC denotes or
T25271 23645-23653 NN denotes FLAG-Tat
T25272 23654-23655 NN denotes C
T25273 23655-23656 -LRB- denotes (
T25274 23656-23664 CD denotes 22,25,27
T25275 23664-23665 -RRB- denotes )
T25276 23665-23666 NN denotes A
T25277 23667-23668 -LRB- denotes (
T25278 23668-23673 NN denotes 10 µl
T25279 23673-23674 -RRB- denotes )
T25280 23675-23680 VB denotes using
T25281 23681-23683 FW denotes in
T25282 23684-23689 FW denotes vitro
T25283 23690-23700 VB denotes translated
T25284 23701-23709 NN denotes proteins
T25285 23711-23720 JJ denotes Wild-type
T25286 23721-23724 CC denotes and
T25287 23725-23731 JJ denotes mutant
T25288 23732-23735 NN denotes Tat
T25289 23736-23744 NN denotes proteins
T25290 23745-23749 VB denotes were
T25291 23750-23768 VB denotes immunoprecipitated
T25292 23769-23773 IN denotes with
T25293 23774-23783 JJ denotes anti-FLAG
T25294 23784-23792 NN denotes antibody
T25295 23792-23793 -COLON- denotes ;
T25296 23794-23809 NN denotes immunocomplexes
T25297 23810-23814 VB denotes were
T25298 23815-23824 VB denotes separated
T25299 23825-23827 IN denotes by
T25300 23828-23830 CD denotes 12
T25301 23830-23831 NN denotes %
T25302 23832-23840 NN denotes SDS–PAGE
T25303 23841-23844 CC denotes and
T25304 23845-23853 VB denotes analysed
T25305 23854-23856 IN denotes by
T25306 23857-23864 JJ denotes western
T25307 23865-23873 NN denotes blotting
T25308 23874-23878 IN denotes with
T25309 23879-23886 JJ denotes anti-HA
T25310 23887-23890 CC denotes and
T25311 23891-23900 JJ denotes anti-FLAG
T25312 23901-23912 NN denotes antibodies.
T25313 23913-23914 -LRB- denotes (
T25314 23914-23915 NN denotes C
T25315 23915-23916 -RRB- denotes )
T25316 23917-23939 JJ denotes 35S-methionine-labeled
T25317 23940-23943 NN denotes p65
T25318 23944-23945 -LRB- denotes (
T25319 23945-23949 NN denotes 5 µl
T25320 23949-23950 -RRB- denotes )
T25321 23951-23954 VB denotes was
T25322 23955-23964 VB denotes incubated
T25323 23965-23969 IN denotes with
T25324 23970-23972 FW denotes in
T25325 23973-23978 FW denotes vitro
T25326 23979-23989 VB denotes translated
T25327 23990-23998 NN denotes HA-IκB-α
T25328 23999-24000 -LRB- denotes (
T25329 24000-24004 NN denotes 5 µl
T25330 24004-24005 -RRB- denotes )
T25331 24006-24008 IN denotes in
T25332 24009-24017 NN denotes presence
T25333 24018-24020 CC denotes or
T25334 24021-24028 NN denotes absence
T25335 24029-24031 IN denotes of
T25336 24032-24040 NN denotes FLAG-Tat
T25337 24041-24043 CC denotes or
T25338 24044-24052 NN denotes FLAG-Tat
T25339 24053-24054 NN denotes R
T25340 24054-24055 -LRB- denotes (
T25341 24055-24060 CD denotes 49–57
T25342 24060-24061 -RRB- denotes )
T25343 24061-24062 NN denotes A
T25344 24063-24064 -LRB- denotes (
T25345 24064-24065 CD denotes 5
T25346 24065-24066 -COMMA- denotes ,
T25347 24067-24069 CD denotes 10
T25348 24070-24072 CC denotes or
T25349 24073-24078 NN denotes 20 µl
T25350 24078-24079 -RRB- denotes )
T25351 24081-24089 NN denotes HA-IκB-α
T25352 24090-24093 VB denotes was
T25353 24094-24112 VB denotes immunoprecipitated
T25354 24113-24117 IN denotes with
T25355 24118-24125 JJ denotes anti-HA
T25356 24126-24134 NN denotes antibody
T25357 24134-24135 -COLON- denotes ;
T25358 24136-24151 NN denotes immunocomplexes
T25359 24152-24156 VB denotes were
T25360 24157-24166 VB denotes separated
T25361 24167-24169 IN denotes by
T25362 24170-24172 CD denotes 12
T25363 24172-24173 NN denotes %
T25364 24174-24182 NN denotes SDS–PAGE
T25365 24183-24186 CC denotes and
T25366 24187-24195 VB denotes analysed
T25367 24196-24198 IN denotes by
T25368 24199-24206 JJ denotes western
T25369 24207-24215 NN denotes blotting
T25370 24216-24220 IN denotes with
T25371 24221-24228 JJ denotes anti-HA
T25372 24229-24232 CC denotes and
T25373 24233-24242 JJ denotes anti-FLAG
T25374 24243-24253 NN denotes antibodies
T25375 24253-24254 -COMMA- denotes ,
T25376 24255-24257 CC denotes or
T25377 24258-24273 NN denotes autoradiography
T25378 24274-24275 -LRB- denotes (
T25379 24275-24286 NN denotes 35S-Met-p65
T25380 24286-24287 -RRB- denotes )
T25381 24289-24301 NN denotes Densitometry
T25382 24302-24308 NN denotes values
T25383 24309-24310 -LRB- denotes (
T25384 24310-24311 NN denotes D
T25385 24311-24312 -RRB- denotes )
T25386 24313-24315 IN denotes of
T25387 24316-24319 DT denotes the
T25388 24320-24325 NN denotes bands
T25389 24326-24330 VB denotes were
T25390 24331-24340 VB denotes expressed
T25391 24341-24343 IN denotes as
T25392 24344-24348 JJ denotes fold
T25393 24349-24357 NN denotes increase
T25394 24358-24363 IN denotes above
T25395 24364-24367 DT denotes the
T25396 24368-24375 NN denotes control
T25397 24376-24377 -LRB- denotes (
T25398 24377-24381 NN denotes lane
T25399 24382-24383 CD denotes 1
T25400 24383-24384 -RRB- denotes )
T25401 24384-24385 -LRB- denotes .
T25402 24386-24387 NN denotes (
T25403 24387-24388 -RRB- denotes D
T25404 24388-24391 DT denotes ) T
T25405 24391-24394 NN denotes he
T25406 24394-24397 NN denotes p65
T25407 24398-24405 NN denotes DNA bin
T25408 24405-24413 NN denotes ding act
T25409 24413-24416 VB denotes ivi
T25410 24416-24424 VB denotes ty was a
T25411 24424-24426 IN denotes na
T25412 24426-24430 NN denotes lyse
T25413 24430-24435 VB denotes d by
T25414 24435-24437 FW denotes EM
T25415 24437-24442 FW denotes SA us
T25416 24442-24452 VB denotes ing in vit
T25417 24452-24460 NN denotes ro trans
T25418 24476-24493 NN denotes 32P-labeled-NF-κB
T25419 24494-24509 JJ denotes double-stranded
T25420 24510-24525 NN denotes oligonucleotide
T25421 24526-24529 VB denotes was
T25422 24530-24539 VB denotes incubated
T25423 24540-24544 IN denotes with
T25424 24545-24548 NN denotes p65
T25425 24549-24550 -LRB- denotes (
T25426 24550-24556 NN denotes 0.5 µl
T25427 24556-24557 -RRB- denotes )
T25428 24558-24560 IN denotes in
T25429 24561-24569 NN denotes presence
T25430 24570-24572 CC denotes or
T25431 24573-24580 NN denotes absence
T25432 24581-24583 IN denotes of
T25433 24584-24592 NN denotes HA-IκB-α
T25434 24593-24594 -LRB- denotes (
T25435 24594-24598 NN denotes 1 µl
T25436 24598-24599 -RRB- denotes )
T25437 24599-24600 -COMMA- denotes ,
T25438 24601-24609 NN denotes FLAG-Tat
T25439 24610-24612 CC denotes or
T25440 24613-24621 NN denotes FLAG-Tat
T25441 24622-24623 NN denotes R
T25442 24623-24624 -LRB- denotes (
T25443 24624-24629 CD denotes 49–57
T25444 24629-24630 -RRB- denotes )
T25445 24630-24631 NN denotes A
T25446 24632-24633 -LRB- denotes (
T25447 24633-24634 CD denotes 5
T25448 24635-24638 CC denotes and
T25449 24639-24644 NN denotes 10 µl
T25450 24644-24645 -RRB- denotes )
T25451 24645-24646 -COLON- denotes ;
T25452 24647-24658 NN denotes competition
T25453 24659-24661 IN denotes of
T25454 24662-24665 NN denotes DNA
T25455 24666-24673 NN denotes binding
T25456 24674-24677 VB denotes was
T25457 24678-24687 VB denotes performed
T25458 24688-24692 IN denotes with
T25459 24693-24697 CD denotes 10 -
T25460 24698-24700 IN denotes up
T25461 24701-24703 TO denotes to
T25462 24704-24712 JJ denotes 100-fold
T25463 24713-24718 JJ denotes molar
T25464 24719-24725 NN denotes excess
T25465 24726-24728 IN denotes of
T25466 24729-24738 JJ denotes unlabeled
T25467 24739-24744 NN denotes NF-κB
T25468 24745-24760 JJ denotes double-stranded
T25469 24761-24776 NN denotes oligonucleotide
T25470 24778-24789 NN denotes DNA/protein
T25471 24790-24799 NN denotes complexes
T25472 24800-24804 VB denotes were
T25473 24805-24808 VB denotes run
T25474 24809-24811 IN denotes on
T25475 24812-24813 CD denotes 6
T25476 24813-24814 NN denotes %
T25477 24815-24823 NN denotes PAGE–TBE
T25478 24824-24827 CC denotes and
T25479 24828-24836 VB denotes analysed
T25480 24837-24839 IN denotes by
T25481 24840-24856 NN denotes autoradiography.
T25482 24857-24858 -LRB- denotes (
T25483 24858-24859 NN denotes E
T25484 24859-24860 -RRB- denotes )
T25485 24861-24877 NN denotes p50−/−p65−/−MEFs
T25486 24878-24879 -LRB- denotes (
T25487 24879-24886 CD denotes 3 × 105
T25488 24887-24892 NN denotes cells
T25489 24892-24893 -RRB- denotes )
T25490 24894-24898 VB denotes were
T25491 24899-24910 VB denotes transfected
T25492 24911-24915 IN denotes with
T25493 24916-24922 NN denotes pκBLuc
T25494 24923-24924 -LRB- denotes (
T25495 24924-24930 NN denotes 0.5 µg
T25496 24930-24931 -RRB- denotes )
T25497 24932-24935 CC denotes and
T25498 24936-24945 JJ denotes pSV-β-Gal
T25499 24946-24947 -LRB- denotes (
T25500 24947-24953 CD denotes 0.1 µg
T25501 24953-24954 -RRB- denotes )
T25502 24955-24959 IN denotes with
T25503 24960-24962 CC denotes or
T25504 24963-24970 IN denotes without
T25505 24971-24982 NN denotes pRc/CMV-p65
T25506 24983-24984 -LRB- denotes (
T25507 24984-24990 CD denotes 0.5 µg
T25508 24990-24991 -RRB- denotes )
T25509 24991-24992 -COMMA- denotes ,
T25510 24993-25007 NN denotes pCMV4-HA-IκB-α
T25511 25008-25009 -LRB- denotes (
T25512 25009-25015 CD denotes 0.5 µg
T25513 25015-25016 -RRB- denotes )
T25514 25016-25017 -COMMA- denotes ,
T25515 25018-25029 NN denotes p3xFLAG-Tat
T25516 25030-25032 CC denotes or
T25517 25033-25044 NN denotes p3xFLAG-Tat
T25518 25045-25046 NN denotes R
T25519 25046-25047 -LRB- denotes (
T25520 25047-25052 CD denotes 49–57
T25521 25052-25053 -RRB- denotes )
T25522 25053-25054 NN denotes A
T25523 25055-25056 -LRB- denotes (
T25524 25056-25059 CD denotes 0.5
T25525 25059-25060 -COMMA- denotes ,
T25526 25061-25062 CD denotes 1
T25527 25063-25066 CC denotes and
T25528 25067-25071 NN denotes 2 µg
T25529 25071-25072 -RRB- denotes )
T25530 25074-25077 DT denotes The
T25531 25078-25088 NN denotes luciferase
T25532 25089-25097 NN denotes activity
T25533 25098-25101 VB denotes was
T25534 25102-25110 VB denotes measured
T25535 25111-25113 IN denotes in
T25536 25114-25118 NN denotes cell
T25537 25119-25127 NN denotes extracts
T25538 25128-25132 JJ denotes 48-h
T25539 25133-25150 JJ denotes post-transfection
T25540 25151-25154 CC denotes and
T25541 25155-25165 VB denotes normalized
T25542 25166-25168 TO denotes to
T25543 25169-25184 JJ denotes β-galactosidase
T25544 25185-25193 NN denotes activity
T25545 25195-25199 JJ denotes Fold
T25546 25200-25210 NN denotes activation
T25547 25211-25214 VB denotes was
T25548 25215-25225 VB denotes calculated
T25549 25226-25234 JJ denotes relative
T25550 25235-25237 TO denotes to
T25551 25238-25250 NN denotes transfection
T25552 25251-25253 IN denotes of
T25553 25254-25257 DT denotes the
T25554 25258-25264 NN denotes pκBLuc
T25555 25265-25272 NN denotes plasmid
T25556 25273-25278 RB denotes alone
T25557 25280-25286 NN denotes Values
T25558 25287-25288 -LRB- denotes (
T25559 25288-25297 NN denotes mean ± SE
T25560 25297-25298 -COMMA- denotes ,
T25561 25299-25304 NN denotes n = 3
T25562 25304-25305 -RRB- denotes )
T25563 25306-25309 VB denotes are
T25564 25310-25315 VB denotes shown
T25565 25317-25319 IN denotes As
T25566 25320-25327 NN denotes control
T25567 25328-25330 IN denotes of
T25568 25331-25338 NN denotes protein
T25569 25339-25349 NN denotes expression
T25570 25349-25350 -COMMA- denotes ,
T25571 25351-25359 NN denotes aliquots
T25572 25360-25362 IN denotes of
T25573 25363-25367 NN denotes cell
T25574 25368-25376 NN denotes extracts
T25575 25377-25378 -LRB- denotes (
T25576 25378-25383 NN denotes 20 µg
T25577 25383-25384 -RRB- denotes )
T25578 25385-25389 VB denotes were
T25579 25390-25398 VB denotes analysed
T25580 25399-25401 IN denotes by
T25581 25402-25409 JJ denotes western
T25582 25410-25418 NN denotes blotting
T25583 25419-25423 IN denotes with
T25584 25424-25432 JJ denotes anti-p65
T25585 25432-25433 -COMMA- denotes ,
T25586 25434-25441 JJ denotes anti-HA
T25587 25441-25442 -COMMA- denotes ,
T25588 25443-25452 JJ denotes anti-FLAG
T25589 25453-25456 CC denotes and
T25590 25457-25471 JJ denotes anti-γ-tubulin
T25591 25472-25482 NN denotes antibodies
T27266 31394-31397 NN denotes Tat
T27267 31398-31407 VB denotes activates
T27268 31408-31411 DT denotes the
T27269 31412-31425 JJ denotes p65-dependent
T27270 31426-31436 NN denotes expression
T27271 31437-31439 IN denotes of
T27272 31440-31456 JJ denotes NF-κB-responsive
T27273 31457-31462 NN denotes genes
T27274 31463-31465 IN denotes by
T27275 31466-31475 VB denotes occupying
T27276 31476-31479 DT denotes the
T27277 31480-31485 NN denotes NF-κB
T27278 31486-31495 NN denotes enhancers
T27279 31496-31499 CC denotes and
T27280 31500-31509 VB denotes promoting
T27281 31510-31513 DT denotes the
T27282 31514-31517 NN denotes p65
T27283 31518-31529 NN denotes recruitment
T27284 31530-31534 IN denotes with
T27285 31535-31540 JJ denotes IκB-α
T27286 31541-31553 NN denotes displacement
T27287 31555-31559 NN denotes HeLa
T27288 31560-31565 NN denotes cells
T27289 31566-31567 -LRB- denotes (
T27290 31567-31574 CD denotes 5 × 106
T27291 31574-31575 -RRB- denotes )
T27292 31576-31580 VB denotes were
T27293 31581-31592 VB denotes transfected
T27294 31593-31597 IN denotes with
T27295 31598-31609 NN denotes p3xFLAG-Tat
T27296 31609-31610 -COMMA- denotes ,
T27297 31611-31622 NN denotes p3xFLAG-Tat
T27298 31623-31624 NN denotes C
T27299 31624-31625 -LRB- denotes (
T27300 31625-31633 CD denotes 22,25,27
T27301 31633-31634 -RRB- denotes )
T27302 31634-31635 -COMMA- denotes ,
T27303 31636-31647 NN denotes p3xFLAG-Tat
T27304 31648-31649 NN denotes R
T27305 31649-31650 -LRB- denotes (
T27306 31650-31655 CD denotes 49–57
T27307 31655-31656 -RRB- denotes )
T27308 31657-31659 CC denotes or
T27309 31660-31665 JJ denotes empty
T27310 31666-31672 NN denotes vector
T27311 31673-31674 -LRB- denotes (
T27312 31674-31679 NN denotes 10 µg
T27313 31679-31680 -RRB- denotes )
T27314 31680-31681 -COLON- denotes ;
T27315 31682-31685 IN denotes for
T27316 31686-31689 NN denotes p65
T27317 31690-31693 NN denotes RNA
T27318 31694-31706 NN denotes interference
T27319 31706-31707 -COMMA- denotes ,
T27320 31708-31713 NN denotes cells
T27321 31714-31715 -LRB- denotes (
T27322 31715-31722 CD denotes 5 × 106
T27323 31722-31723 -RRB- denotes )
T27324 31724-31728 VB denotes were
T27325 31729-31740 VB denotes transfected
T27326 31741-31745 IN denotes with
T27327 31746-31757 NN denotes p3xFLAG-Tat
T27328 31758-31759 -LRB- denotes (
T27329 31759-31764 NN denotes 10 µg
T27330 31764-31765 -RRB- denotes )
T27331 31766-31769 CC denotes and
T27332 31770-31775 NN denotes siRNA
T27333 31776-31779 NN denotes p65
T27334 31780-31782 CC denotes or
T27335 31783-31788 NN denotes siRNA
T27336 31789-31796 NN denotes control
T27337 31797-31798 -LRB- denotes (
T27338 31798-31806 NN denotes 200 pmol
T27339 31806-31807 -RRB- denotes )
T27340 31809-31825 CD denotes Twenty-four-hour
T27341 31826-31843 JJ denotes post-transfection
T27342 31843-31844 -COMMA- denotes ,
T27343 31845-31850 JJ denotes total
T27344 31851-31854 NN denotes RNA
T27345 31855-31858 VB denotes was
T27346 31859-31868 VB denotes extracted
T27347 31869-31872 CC denotes and
T27348 31873-31881 VB denotes analysed
T27349 31882-31884 IN denotes by
T27350 31885-31894 JJ denotes real-time
T27351 31895-31898 NN denotes PCR
T27352 31899-31901 TO denotes to
T27353 31902-31910 VB denotes evaluate
T27354 31911-31914 DT denotes the
T27355 31915-31925 NN denotes expression
T27356 31926-31928 IN denotes of
T27357 31929-31935 NN denotes MIP-1α
T27358 31936-31937 -LRB- denotes (
T27359 31937-31938 NN denotes A
T27360 31938-31939 -RRB- denotes )
T27361 31939-31940 -COMMA- denotes ,
T27362 31941-31945 NN denotes CSF3
T27363 31946-31947 -LRB- denotes (
T27364 31947-31948 NN denotes B
T27365 31948-31949 -RRB- denotes )
T27366 31949-31950 -COMMA- denotes ,
T27367 31951-31954 NN denotes LTA
T27368 31955-31956 -LRB- denotes (
T27369 31956-31957 NN denotes C
T27370 31957-31958 -RRB- denotes )
T27371 31958-31959 -COMMA- denotes ,
T27372 31960-31966 NN denotes NFKBIA
T27373 31967-31968 -LRB- denotes (
T27374 31968-31969 NN denotes D
T27375 31969-31970 -RRB- denotes )
T27376 31970-31971 -COMMA- denotes ,
T27377 31972-31976 NN denotes TLR2
T27378 31977-31978 -LRB- denotes (
T27379 31978-31979 NN denotes E
T27380 31979-31980 -RRB- denotes )
T27381 31980-31981 -COMMA- denotes ,
T27382 31982-31987 NN denotes GAPDH
T27383 31988-31989 -LRB- denotes (
T27384 31989-31990 NN denotes F
T27385 31990-31991 -RRB- denotes )
T27386 31991-31992 -COMMA- denotes ,
T27387 31993-31997 NN denotes ACTB
T27388 31998-31999 -LRB- denotes (
T27389 31999-32000 NN denotes G
T27390 32000-32001 -RRB- denotes )
T27391 32002-32008 NN denotes genes.
T27392 32009-32010 -LRB- denotes (
T27393 32010-32011 NN denotes H
T27394 32011-32012 -RRB- denotes )
T27395 32013-32017 NN denotes HeLa
T27396 32018-32023 NN denotes cells
T27397 32024-32025 -LRB- denotes (
T27398 32025-32032 CD denotes 5 × 106
T27399 32032-32033 -RRB- denotes )
T27400 32034-32038 VB denotes were
T27401 32039-32050 VB denotes transfected
T27402 32051-32055 IN denotes with
T27403 32056-32067 NN denotes p3xFLAG-Tat
T27404 32067-32068 -COMMA- denotes ,
T27405 32069-32071 CC denotes or
T27406 32072-32077 JJ denotes empty
T27407 32078-32084 NN denotes vector
T27408 32085-32086 -LRB- denotes (
T27409 32086-32091 NN denotes 10 µg
T27410 32091-32092 -RRB- denotes )
T27411 32093-32096 CC denotes and
T27412 32097-32101 NN denotes 48 h
T27413 32102-32107 JJ denotes later
T27414 32108-32112 NN denotes ChIP
T27415 32113-32116 VB denotes was
T27416 32117-32126 VB denotes performed
T27417 32127-32131 IN denotes with
T27418 32132-32140 JJ denotes anti-p65
T27419 32141-32149 NN denotes antibody
T27420 32151-32160 JJ denotes Real-time
T27421 32161-32164 NN denotes PCR
T27422 32165-32168 VB denotes was
T27423 32169-32178 VB denotes performed
T27424 32179-32183 IN denotes with
T27425 32184-32191 NN denotes primers
T27426 32192-32200 JJ denotes specific
T27427 32201-32204 IN denotes for
T27428 32205-32208 DT denotes the
T27429 32209-32218 VB denotes indicated
T27430 32219-32229 NN denotes promoters.
T27431 32230-32231 -LRB- denotes (
T27432 32231-32232 CD denotes I
T27433 32232-32233 -RRB- denotes )
T27434 32234-32238 NN denotes HeLa
T27435 32239-32244 NN denotes cells
T27436 32245-32246 -LRB- denotes (
T27437 32246-32253 CD denotes 5 × 106
T27438 32253-32254 -RRB- denotes )
T27439 32255-32259 VB denotes were
T27440 32260-32271 VB denotes transfected
T27441 32272-32276 IN denotes with
T27442 32277-32282 JJ denotes empty
T27443 32283-32289 NN denotes vector
T27444 32289-32290 -COMMA- denotes ,
T27445 32291-32293 CC denotes or
T27446 32294-32305 NN denotes p3xFLAG-Tat
T27447 32306-32307 -LRB- denotes (
T27448 32307-32312 NN denotes 10 µg
T27449 32312-32313 -RRB- denotes )
T27450 32314-32316 IN denotes in
T27451 32317-32325 NN denotes presence
T27452 32326-32328 CC denotes or
T27453 32329-32336 NN denotes absence
T27454 32337-32339 IN denotes of
T27455 32340-32345 NN denotes siRNA
T27456 32346-32349 NN denotes p65
T27457 32349-32350 -COMMA- denotes ,
T27458 32351-32353 CC denotes or
T27459 32354-32359 NN denotes siRNA
T27460 32360-32367 NN denotes control
T27461 32368-32369 -LRB- denotes (
T27462 32369-32377 NN denotes 200 pmol
T27463 32377-32378 -RRB- denotes )
T27464 32378-32379 -COLON- denotes ;
T27465 32380-32384 NN denotes 48 h
T27466 32385-32390 RB denotes later
T27467 32390-32391 -COMMA- denotes ,
T27468 32392-32396 NN denotes ChIP
T27469 32397-32400 VB denotes was
T27470 32401-32410 VB denotes performed
T27471 32411-32415 IN denotes with
T27472 32416-32425 JJ denotes anti-FLAG
T27473 32426-32434 NN denotes antibody
T27474 32436-32445 JJ denotes Real-time
T27475 32446-32449 NN denotes PCR
T27476 32450-32453 VB denotes was
T27477 32454-32463 VB denotes performed
T27478 32464-32468 IN denotes with
T27479 32469-32476 NN denotes primers
T27480 32477-32485 JJ denotes specific
T27481 32486-32489 IN denotes for
T27482 32490-32493 DT denotes the
T27483 32494-32503 VB denotes indicated
T27484 32504-32514 NN denotes promoters.
T27485 32515-32516 -LRB- denotes (
T27486 32516-32517 NN denotes J
T27487 32517-32518 -RRB- denotes )
T27488 32519-32523 NN denotes HeLa
T27489 32524-32529 NN denotes cells
T27490 32530-32531 -LRB- denotes (
T27491 32531-32538 CD denotes 5 × 106
T27492 32538-32539 -RRB- denotes )
T27493 32540-32544 VB denotes were
T27494 32545-32556 VB denotes transfected
T27495 32557-32561 IN denotes with
T27496 32562-32567 JJ denotes empty
T27497 32568-32574 NN denotes vector
T27498 32574-32575 -COMMA- denotes ,
T27499 32576-32587 NN denotes p3xFLAG-Tat
T27500 32588-32589 -LRB- denotes (
T27501 32589-32594 NN denotes 10 µg
T27502 32594-32595 -RRB- denotes )
T27503 32595-32596 -COMMA- denotes ,
T27504 32597-32599 CC denotes or
T27505 32600-32605 JJ denotes empty
T27506 32606-32612 NN denotes vector
T27507 32613-32617 CC denotes plus
T27508 32618-32623 NN denotes siRNA
T27509 32624-32629 NN denotes IκB-α
T27510 32630-32632 CC denotes or
T27511 32633-32638 NN denotes siRNA
T27512 32639-32646 NN denotes control
T27513 32647-32648 -LRB- denotes (
T27514 32648-32656 NN denotes 200 pmol
T27515 32656-32657 -RRB- denotes )
T27516 32657-32658 -COLON- denotes ;
T27517 32659-32663 NN denotes 48 h
T27518 32664-32669 RB denotes later
T27519 32669-32670 -COMMA- denotes ,
T27520 32671-32675 NN denotes ChIP
T27521 32676-32679 VB denotes was
T27522 32680-32689 VB denotes performed
T27523 32690-32694 IN denotes with
T27524 32695-32705 JJ denotes anti-IκB-α
T27525 32706-32714 NN denotes antibody
T27526 32716-32725 JJ denotes Real-time
T27527 32726-32729 NN denotes PCR
T27528 32730-32733 VB denotes was
T27529 32734-32743 VB denotes performed
T27530 32744-32748 IN denotes with
T27531 32749-32756 NN denotes primers
T27532 32757-32765 JJ denotes specific
T27533 32766-32769 IN denotes for
T27534 32770-32773 DT denotes the
T27535 32774-32783 JJ denotes indicated
T27536 32784-32793 NN denotes promoters
T27537 32795-32801 NN denotes Values
T27538 32802-32803 -LRB- denotes (
T27539 32803-32812 NN denotes mean ± SE
T27540 32812-32813 -COMMA- denotes ,
T27541 32814-32819 NN denotes n = 3
T27542 32819-32820 -RRB- denotes )
T27543 32821-32824 VB denotes are
T27544 32825-32830 VB denotes shown
T27545 32832-32835 DT denotes The
T27546 32836-32845 NN denotes asterisks
T27547 32846-32854 VB denotes indicate
T27548 32855-32868 RB denotes statistically
T27549 32869-32880 JJ denotes significant
T27550 32881-32892 NN denotes differences
T27551 32893-32901 VB denotes compared
T27552 32902-32904 TO denotes to
T27553 32905-32908 DT denotes the
T27554 32909-32916 NN denotes control
T27555 32917-32918 -LRB- denotes (
T27556 32918-32923 JJ denotes empty
T27557 32924-32930 NN denotes vector
T27558 32930-32931 -RRB- denotes )
T27559 32932-32941 VB denotes according
T27560 32942-32944 TO denotes to
T27561 32945-32948 DT denotes the
T27562 32949-32956 NN denotes Student
T27563 32956-32958 POS denotes 's
T27564 32959-32965 NN denotes t-test
T27565 32966-32967 -LRB- denotes (
T27566 32967-32969 NN denotes P 
T27567 32969-32970 SYM denotes <
T27568 32970-32975 CD denotes  0.05
T27569 32975-32976 -RRB- denotes )
T29104 43632-43637 NN denotes Model
T29105 43638-43640 IN denotes of
T29106 43641-43647 NN denotes MIP-1α
T29107 43648-43663 JJ denotes transcriptional
T29108 43664-43674 NN denotes activation
T29109 43675-43677 IN denotes by
T29110 43678-43683 NN denotes HIV-1
T29111 43684-43688 NN denotes Tat.
T29112 43689-43690 -LRB- denotes (
T29113 43690-43691 NN denotes A
T29114 43691-43692 -RRB- denotes )
T29115 43693-43695 IN denotes In
T29116 43696-43703 NN denotes absence
T29117 43704-43706 IN denotes of
T29118 43707-43710 NN denotes Tat
T29119 43710-43711 -COMMA- denotes ,
T29120 43712-43717 NNP denotes IκB-α
T29121 43718-43726 VB denotes occupies
T29122 43727-43730 DT denotes the
T29123 43731-43736 NN denotes NF-κB
T29124 43737-43745 NN denotes enhancer
T29125 43746-43748 IN denotes of
T29126 43749-43752 DT denotes the
T29127 43753-43759 NN denotes MIP-1α
T29128 43760-43768 NN denotes promoter
T29129 43769-43772 CC denotes and
T29130 43773-43779 RB denotes likely
T29131 43780-43789 VB denotes interacts
T29132 43790-43794 IN denotes with
T29133 43795-43810 JJ denotes transcriptional
T29134 43811-43821 NN denotes repressors
T29135 43821-43822 -COMMA- denotes ,
T29136 43823-43827 JJ denotes such
T29137 43828-43830 IN denotes as
T29138 43831-43836 NN denotes HDACs
T29139 43837-43838 -LRB- denotes (
T29140 43838-43840 CD denotes 65
T29141 43840-43841 -RRB- denotes )
T29142 43841-43842 -COMMA- denotes ,
T29143 43843-43845 TO denotes to
T29144 43846-43853 VB denotes inhibit
T29145 43854-43858 NN denotes gene
T29146 43859-43873 NN denotes transcription.
T29147 43874-43875 -LRB- denotes (
T29148 43875-43876 NN denotes B
T29149 43876-43877 -RRB- denotes )
T29150 43878-43881 NN denotes Tat
T29151 43882-43891 VB denotes activates
T29152 43892-43895 DT denotes the
T29153 43896-43902 NN denotes MIP-1α
T29154 43903-43913 NN denotes expression
T29155 43914-43916 IN denotes by
T29156 43917-43925 VB denotes removing
T29157 43926-43929 DT denotes the
T29158 43930-43935 JJ denotes IκB-α
T29159 43936-43945 NN denotes repressor
T29160 43946-43950 IN denotes from
T29161 43951-43954 DT denotes the
T29162 43955-43960 NN denotes NF-κB
T29163 43961-43969 NN denotes enhancer
T29164 43969-43970 -COMMA- denotes ,
T29165 43971-43974 CC denotes and
T29166 43975-43977 IN denotes by
T29167 43978-43988 VB denotes increasing
T29168 43989-43992 DT denotes the
T29169 43993-44000 NN denotes binding
T29170 44001-44003 IN denotes of
T29171 44004-44007 NN denotes p65
T29172 44008-44013 NN denotes NF-κB
T29173 44014-44021 NN denotes complex
T29174 44022-44024 TO denotes to
T29175 44025-44028 DT denotes the
T29176 44029-44034 NN denotes NF-κB
T29177 44035-44043 NN denotes enhancer
T6077 9014-9017 CC denotes and
T6895 11282-11285 NN denotes GST
T6896 11286-11294 NN denotes proteins
T6897 11295-11297 IN denotes in
T6898 11298-11309 FW denotes Escherichia
T6899 11310-11314 FW denotes coli
T6900 11315-11321 NN denotes strain
T6901 11322-11326 NN denotes BL21
T6902 11327-11331 VB denotes were
T6903 11332-11341 VB denotes performed
T6904 11342-11344 IN denotes as
T6905 11345-11355 RB denotes previously
T6906 11356-11364 VB denotes reported
T6907 11365-11366 -LRB- denotes (
T6908 11366-11368 CD denotes 50
T6909 11368-11369 -RRB- denotes )
T6910 11371-11378 NN denotes Details
T6911 11379-11382 VB denotes are
T6912 11383-11392 VB denotes described
T6913 11393-11395 IN denotes in
T6914 11396-11409 NNP denotes Supplementary
T6915 11410-11414 NNP denotes Data
R74 T145 T142 arg1Of Tat,Human
R75 T145 T143 arg1Of Tat,immunodeficiency
R76 T145 T144 arg1Of Tat,virus-1
R77 T145 T146 arg1Of Tat,activates
R78 T146 T148 arg1Of activates,via
R79 T147 T146 arg2Of NF-κB,activates
R80 T150 T148 arg2Of interaction,via
R81 T150 T149 arg1Of interaction,physical
R82 T150 T151 arg1Of interaction,with
R83 T152 T153 arg1Of IκB-α,and
R84 T153 T151 arg2Of and,with
R85 T154 T153 arg2Of p65,and
R86 T156 T155 arg1Of factor,Nuclear
R87 T156 T157 arg1Of factor,(
R88 T158 T157 arg2Of NF,(
R89 T159 T157 arg3Of ),(
R90 T160 T156 arg1Of -κB,factor
R91 T160 T161 arg1Of -κB,is
R92 T160 T169 arg1Of -κB,is
R93 T160 T170 arg2Of -κB,upregulated
R94 T161 T168 arg1Of is,and
R95 T164 T161 arg2Of regulator,is
R96 T164 T162 arg1Of regulator,a
R97 T164 T163 arg1Of regulator,master
R98 T164 T165 arg1Of regulator,of
R99 T167 T165 arg2Of genes,of
R100 T167 T166 arg1Of genes,pro-inflammatory
R101 T170 T168 arg2Of upregulated,and
R102 T170 T169 arg2Of upregulated,is
R103 T170 T171 arg1Of upregulated,in
R104 T174 T172 arg1Of virus,human
R105 T174 T173 arg1Of virus,immunodeficiency
R106 T174 T175 arg1Of virus,1
R107 T174 T176 arg1Of virus,(
R108 T177 T176 arg2Of HIV-1,(
R109 T178 T176 arg3Of ),(
R110 T179 T171 arg2Of infection,in
R111 T179 T174 arg1Of infection,virus
R112 T180 T181 arg1Of Mechanisms,underlying
R113 T180 T187 arg1Of Mechanisms,are
R114 T180 T188 arg1Of Mechanisms,relevant
R115 T184 T181 arg2Of deregulation,underlying
R116 T184 T182 arg1Of deregulation,the
R117 T184 T183 arg1Of deregulation,NF-κB
R118 T184 T185 arg1Of deregulation,by
R119 T186 T185 arg2Of HIV-1,by
R120 T188 T187 arg2Of relevant,are
R121 T188 T189 arg1Of relevant,for
R122 T191 T189 arg2Of dysfunction,for
R123 T191 T190 arg1Of dysfunction,immune
R124 T191 T192 arg1Of dysfunction,in
R125 T193 T192 arg2Of AIDS,in
R126 T194 T195 arg1Of We,report
R127 T201 T198 arg1Of infection,single
R128 T201 T199 arg1Of infection,round
R129 T201 T200 arg1Of infection,HIV-1
R130 T201 T203 arg1Of infection,or
R131 T203 T197 arg2Of or,in
R132 T203 T202 arg1Of or,","
R133 T206 T203 arg2Of stimulation,or
R134 T206 T204 arg1Of stimulation,single-pulse
R135 T206 T205 arg1Of stimulation,PMA
R136 T211 T208 arg1Of transactivator,the
R137 T211 T209 arg1Of transactivator,HIV-1
R138 T211 T210 arg1Of transactivator,Tat
R139 T211 T212 arg1Of transactivator,activated
R140 T211 T215 arg1Of transactivator,hijacking
R141 T211 T221 arg1Of transactivator,preventing
R142 T212 T195 arg2Of activated,report
R143 T212 T196 arg1Of activated,that
R144 T212 T197 arg1Of activated,in
R145 T212 T207 arg1Of activated,","
R146 T212 T214 arg1Of activated,by
R147 T212 T220 arg1Of activated,by
R148 T213 T212 arg2Of NF-κB,activated
R149 T214 T219 arg1Of by,and
R150 T215 T214 arg2Of hijacking,by
R151 T218 T215 arg2Of IκB-α,hijacking
R152 T218 T216 arg1Of IκB-α,the
R153 T218 T217 arg1Of IκB-α,inhibitor
R154 T220 T219 arg2Of by,and
R155 T221 T220 arg2Of preventing,by
R156 T224 T221 arg2Of binding,preventing
R157 T224 T222 arg1Of binding,the
R158 T224 T223 arg1Of binding,repressor
R159 T224 T225 arg1Of binding,to
R160 T228 T225 arg2Of complex,to
R161 T228 T226 arg1Of complex,the
R162 T228 T227 arg1Of complex,NF-κB
R163 T231 T232 arg1Of Tat,associated
R164 T231 T240 arg1Of Tat,increased
R165 T232 T233 arg1Of associated,with
R166 T232 T239 arg1Of associated,and
R167 T236 T233 arg2Of subunit,with
R168 T236 T234 arg1Of subunit,the
R169 T236 T235 arg1Of subunit,p65
R170 T236 T237 arg1Of subunit,of
R171 T238 T237 arg2Of NF-κB,of
R172 T239 T229 arg1Of and,Moreover
R173 T239 T230 arg1Of and,","
R174 T240 T239 arg2Of increased,and
R175 T244 T242 arg1Of affinity,p65
R176 T244 T243 arg1Of affinity,DNA-binding
R177 T244 T245 arg1Of affinity,and
R178 T245 T240 arg2Of and,increased
R179 T245 T241 arg1Of and,the
R180 T247 T245 arg2Of activity,and
R181 T247 T246 arg1Of activity,transcriptional
R182 T249 T250 arg1Of arginine-,and
R183 T251 T250 arg2Of cysteine-rich,and
R184 T252 T248 arg1Of domains,The
R185 T252 T249 arg1Of domains,arginine-
R186 T252 T251 arg1Of domains,cysteine-rich
R187 T252 T253 arg1Of domains,of
R188 T252 T255 arg1Of domains,were
R189 T252 T256 arg2Of domains,required
R190 T254 T253 arg2Of Tat,of
R191 T256 T255 arg2Of required,were
R192 T256 T257 arg1Of required,for
R193 T256 T262 arg1Of required,","
R194 T256 T263 arg1Of required,respectively
R195 T256 T264 arg1Of required,","
R196 T256 T265 arg1Of required,and
R197 T258 T259 arg1Of IκB-α,and
R198 T259 T257 arg2Of and,for
R199 T261 T259 arg2Of association,and
R200 T261 T260 arg1Of association,p65
R201 T266 T256 arg3Of for,required
R202 T267 T266 arg2Of sustaining,for
R203 T270 T267 arg2Of activity,sustaining
R204 T270 T268 arg1Of activity,the
R205 T270 T269 arg1Of activity,NF-κB
R206 T273 T271 arg2Of array,Among
R207 T273 T272 arg1Of array,an
R208 T273 T274 arg1Of array,of
R209 T276 T274 arg2Of genes,of
R210 T276 T275 arg1Of genes,NF-κB-responsive
R211 T278 T280 arg1Of Tat,activated
R212 T278 T290 arg1Of Tat,bound
R213 T280 T284 arg1Of activated,in
R214 T280 T289 arg1Of activated,and
R215 T283 T280 arg2Of expression,activated
R216 T283 T281 arg1Of expression,the
R217 T283 T282 arg1Of expression,MIP-1α
R218 T287 T284 arg2Of manner,in
R219 T287 T285 arg1Of manner,a
R220 T287 T286 arg1Of manner,p65-dependent
R221 T289 T271 arg1Of and,Among
R222 T289 T277 arg1Of and,","
R223 T289 T279 arg1Of and,mostly
R224 T289 T288 arg1Of and,","
R225 T290 T289 arg2Of bound,and
R226 T290 T291 arg1Of bound,to
R227 T295 T291 arg2Of enhancer,to
R228 T295 T292 arg1Of enhancer,the
R229 T295 T293 arg1Of enhancer,MIP-1α
R230 T295 T294 arg1Of enhancer,NF-κB
R231 T295 T297 arg1Of enhancer,promoting
R232 T297 T296 arg1Of promoting,thus
R233 T297 T306 arg1Of promoting,;
R234 T299 T297 arg2Of recruitment,promoting
R235 T299 T298 arg1Of recruitment,the
R236 T299 T300 arg1Of recruitment,of
R237 T299 T302 arg1Of recruitment,with
R238 T301 T300 arg2Of p65,of
R239 T303 T302 arg2Of displacement,with
R240 T303 T304 arg1Of displacement,of
R241 T305 T304 arg2Of IκB-α,of
R242 T308 T307 arg1Of findings,similar
R243 T308 T309 arg1Of findings,were
R244 T308 T310 arg2Of findings,obtained
R245 T310 T306 arg2Of obtained,;
R246 T310 T309 arg2Of obtained,were
R247 T310 T311 arg1Of obtained,for
R248 T314 T312 arg1Of genes,the
R249 T314 T313 arg1Of genes,NF-κB-responsive
R250 T315 T316 arg1Of CSF3,","
R251 T316 T318 arg1Of ",",","
R252 T317 T316 arg2Of LTA,","
R253 T318 T320 arg1Of ",",and
R254 T319 T318 arg2Of NFKBIA,","
R255 T320 T311 arg2Of and,for
R256 T320 T314 arg1Of and,genes
R257 T321 T320 arg2Of TLR2,and
R258 T323 T322 arg1Of results,Our
R259 T323 T324 arg1Of results,support
R260 T323 T342 arg1Of results,may
R261 T323 T343 arg1Of results,contribute
R262 T324 T341 arg1Of support,and
R263 T327 T324 arg2Of mechanism,support
R264 T327 T325 arg1Of mechanism,a
R265 T327 T326 arg1Of mechanism,novel
R266 T327 T328 arg1Of mechanism,of
R267 T327 T331 arg1Of mechanism,via
R268 T330 T328 arg2Of activation,of
R269 T330 T329 arg1Of activation,NF-κB
R270 T333 T331 arg2Of interaction,via
R271 T333 T332 arg1Of interaction,physical
R272 T333 T334 arg1Of interaction,of
R273 T333 T336 arg1Of interaction,with
R274 T335 T334 arg2Of Tat,of
R275 T337 T338 arg1Of IκB-α,and
R276 T338 T336 arg2Of and,with
R277 T339 T338 arg2Of p65,and
R278 T341 T340 arg1Of and,","
R279 T343 T341 arg2Of contribute,and
R280 T343 T342 arg2Of contribute,may
R281 T343 T344 arg1Of contribute,to
R282 T346 T344 arg2Of insights,to
R283 T346 T345 arg1Of insights,further
R284 T346 T347 arg1Of insights,into
R285 T349 T347 arg2Of deregulation,into
R286 T349 T348 arg1Of deregulation,the
R287 T349 T350 arg1Of deregulation,of
R288 T349 T354 arg1Of deregulation,by
R289 T353 T350 arg2Of response,of
R290 T353 T351 arg1Of response,the
R291 T353 T352 arg1Of response,inflammatory
R292 T355 T354 arg2Of HIV-1,by
R1275 T1457 T1456 arg2Of NF,(
R1276 T1458 T1456 arg3Of ),(
R1279 T1461 T1454 arg1Of factors,Nuclear
R1280 T1461 T1455 arg1Of factors,factor
R1281 T1461 T1456 arg1Of factors,(
R1282 T1461 T1459 arg1Of factors,-κB
R1285 T1464 T1465 arg1Of transcription,of
R1286 T1466 T1465 arg2Of genes,of
R1287 T1466 T1467 arg1Of genes,that
R1288 T1466 T1468 arg1Of genes,are
R1289 T1466 T1469 arg2Of genes,involved
R1290 T1469 T1468 arg2Of involved,are
R1291 T1469 T1470 arg1Of involved,in
R1292 T1472 T1473 arg1Of immune,and
R1293 T1474 T1473 arg2Of inflammatory,and
R1294 T1475 T1470 arg2Of response,in
R1295 T1475 T1471 arg1Of response,the
R1296 T1475 T1472 arg1Of response,immune
R1297 T1475 T1474 arg1Of response,inflammatory
R1298 T1475 T1476 arg1Of response,(
R1299 T1477 T1476 arg2Of 1,(
R1300 T1478 T1476 arg3Of ),(
R1301 T1481 T1479 arg1Of family,The
R1302 T1481 T1480 arg1Of family,NF-κB
R1303 T1481 T1482 arg1Of family,includes
R1304 T1483 T1484 arg1Of RelA/p65,","
R1305 T1484 T1486 arg1Of ",",","
R1306 T1485 T1484 arg2Of c-Rel,","
R1307 T1486 T1488 arg1Of ",",","
R1308 T1487 T1486 arg2Of RelB,","
R1309 T1488 T1482 arg2Of ",",includes
R1310 T1488 T1492 arg1Of ",",that
R1311 T1488 T1493 arg1Of ",",share
R1312 T1489 T1490 arg1Of p50,and
R1313 T1490 T1488 arg2Of and,","
R1314 T1491 T1490 arg2Of p52,and
R1315 T1493 T1505 arg1Of share,for
R1316 T1496 T1495 arg1Of conserved,highly
R1317 T1501 T1493 arg2Of domain,share
R1318 T1501 T1494 arg1Of domain,a
R1319 T1501 T1496 arg1Of domain,conserved
R1320 T1501 T1497 arg1Of domain,300-amino
R1321 T1501 T1498 arg1Of domain,acid
R1322 T1501 T1499 arg1Of domain,Rel
R1323 T1501 T1500 arg1Of domain,homology
R1324 T1501 T1502 arg1Of domain,(
R1325 T1503 T1502 arg2Of RHD,(
R1326 T1504 T1502 arg3Of ),(
R1327 T1506 T1507 arg1Of homo-,or
R1328 T1507 T1505 arg2Of or,for
R1329 T1508 T1509 arg1Of hetero-dimerization,and
R1330 T1509 T1507 arg2Of and,or
R1331 T1510 T1509 arg2Of DNA-binding,and
R1332 T1513 T1511 arg1Of activity,The
R1333 T1513 T1512 arg1Of activity,transcriptional
R1334 T1513 T1514 arg1Of activity,of
R1335 T1513 T1518 arg1Of activity,depends
R1336 T1517 T1514 arg2Of complex,of
R1337 T1517 T1515 arg1Of complex,the
R1338 T1517 T1516 arg1Of complex,NF-κB
R1339 T1518 T1519 arg1Of depends,on
R1340 T1518 T1522 arg1Of depends,since
R1341 T1521 T1519 arg2Of composition,on
R1342 T1521 T1520 arg1Of composition,dimer
R1343 T1527 T1523 arg1Of domains,C-terminal
R1344 T1527 T1524 arg1Of domains,unrelated
R1345 T1527 T1525 arg1Of domains,transcriptional
R1346 T1527 T1526 arg1Of domains,activation
R1347 T1527 T1528 arg1Of domains,are
R1348 T1527 T1529 arg1Of domains,present
R1349 T1528 T1522 arg2Of are,since
R1350 T1529 T1528 arg2Of present,are
R1351 T1529 T1531 arg1Of present,in
R1352 T1531 T1530 arg1Of in,exclusively
R1353 T1532 T1533 arg1Of p65,","
R1354 T1533 T1535 arg1Of ",",and
R1355 T1534 T1533 arg2Of RelB,","
R1356 T1535 T1531 arg2Of and,in
R1357 T1536 T1535 arg2Of c-Rel,and
R1358 T1536 T1537 arg1Of c-Rel,(
R1359 T1538 T1537 arg2Of 2,(
R1360 T1539 T1537 arg3Of ),(
R1361 T1540 T1541 arg1Of Inhibitors,of
R1362 T1540 T1546 arg1Of Inhibitors,associate
R1363 T1540 T1552 arg1Of Inhibitors,interfere
R1364 T1542 T1541 arg2Of NF-κB,of
R1365 T1542 T1543 arg1Of NF-κB,(
R1366 T1544 T1543 arg2Of IκB,(
R1367 T1545 T1543 arg3Of ),(
R1368 T1546 T1547 arg1Of associate,with
R1369 T1546 T1551 arg1Of associate,and
R1370 T1550 T1547 arg2Of complex,with
R1371 T1550 T1548 arg1Of complex,the
R1372 T1550 T1549 arg1Of complex,NF-κB
R1373 T1552 T1551 arg2Of interfere,and
R1374 T1552 T1553 arg1Of interfere,with
R1375 T1555 T1553 arg2Of binding,with
R1376 T1555 T1554 arg1Of binding,its
R1377 T1555 T1556 arg1Of binding,to
R1378 T1557 T1556 arg2Of DNA,to
R1379 T1557 T1558 arg1Of DNA,(
R1380 T1559 T1558 arg2Of 3,(
R1381 T1560 T1558 arg3Of ),(
R1382 T1564 T1561 arg2Of pathway,In
R1383 T1564 T1562 arg1Of pathway,the
R1384 T1564 T1563 arg1Of pathway,canonical
R1385 T1564 T1565 arg1Of pathway,of
R1386 T1567 T1565 arg2Of activation,of
R1387 T1567 T1566 arg1Of activation,NF-κB
R1388 T1572 T1569 arg1Of kinase,the
R1389 T1572 T1570 arg2Of kinase,activated
R1390 T1572 T1571 arg1Of kinase,IκB
R1391 T1572 T1573 arg1Of kinase,(
R1392 T1572 T1576 arg1Of kinase,phosphorylates
R1393 T1574 T1573 arg2Of IKK,(
R1394 T1575 T1573 arg3Of ),(
R1395 T1576 T1561 arg1Of phosphorylates,In
R1396 T1576 T1568 arg1Of phosphorylates,","
R1397 T1576 T1578 arg1Of phosphorylates,at
R1398 T1577 T1576 arg2Of IκB,phosphorylates
R1399 T1581 T1578 arg2Of residues,at
R1400 T1581 T1579 arg1Of residues,specific
R1401 T1581 T1580 arg1Of residues,serine
R1402 T1581 T1582 arg1Of residues,that
R1403 T1581 T1583 arg1Of residues,target
R1404 T1585 T1583 arg2Of protein,target
R1405 T1585 T1584 arg1Of protein,the
R1406 T1585 T1586 arg1Of protein,to
R1407 T1587 T1588 arg1Of ubiquitination,and
R1408 T1588 T1586 arg2Of and,to
R1409 T1588 T1591 arg1Of and,","
R1410 T1588 T1592 arg1Of and,which
R1411 T1588 T1593 arg1Of and,releases
R1412 T1590 T1588 arg2Of degradation,and
R1413 T1590 T1589 arg1Of degradation,proteasomal
R1414 T1597 T1593 arg2Of complex,releases
R1415 T1597 T1594 arg1Of complex,the
R1416 T1597 T1595 arg1Of complex,functional
R1417 T1597 T1596 arg1Of complex,NF-κB
R1418 T1597 T1598 arg1Of complex,in
R1419 T1600 T1598 arg2Of nucleus,in
R1420 T1600 T1599 arg1Of nucleus,the
R1421 T1601 T1602 arg1Of IκB-α,","
R1422 T1601 T1613 arg1Of IκB-α,is
R1423 T1601 T1614 arg2Of IκB-α,phosphorylated
R1424 T1601 T1627 arg2Of IκB-α,ubiquitylated
R1425 T1605 T1604 arg1Of abundant,most
R1426 T1606 T1602 arg2Of inhibitor,","
R1427 T1606 T1603 arg1Of inhibitor,the
R1428 T1606 T1605 arg1Of inhibitor,abundant
R1429 T1606 T1607 arg1Of inhibitor,of
R1430 T1608 T1607 arg2Of NF-κB,of
R1431 T1608 T1609 arg1Of NF-κB,(
R1432 T1610 T1609 arg2Of 4,(
R1433 T1611 T1609 arg3Of ),(
R1434 T1614 T1625 arg1Of phosphorylated,and
R1435 T1616 T1614 arg1Of IKK,phosphorylated
R1436 T1616 T1615 arg2Of IKK,by
R1437 T1616 T1617 arg1Of IKK,at
R1438 T1618 T1619 arg1Of Ser32,and
R1439 T1619 T1617 arg2Of and,at
R1440 T1620 T1619 arg2Of Ser36,and
R1441 T1620 T1621 arg1Of Ser36,(
R1442 T1622 T1621 arg2Of 5,(
R1443 T1623 T1621 arg3Of ),(
R1444 T1625 T1612 arg1Of and,","
R1445 T1625 T1613 arg2Of and,is
R1446 T1625 T1624 arg1Of and,","
R1447 T1627 T1625 arg2Of ubiquitylated,and
R1448 T1627 T1626 arg1Of ubiquitylated,subsequently
R1449 T1627 T1628 arg1Of ubiquitylated,at
R1450 T1629 T1630 arg1Of Lys21,and
R1451 T1630 T1628 arg2Of and,at
R1452 T1630 T1632 modOf and,to
R1453 T1630 T1633 arg1Of and,be
R1454 T1630 T1634 arg2Of and,degraded
R1455 T1631 T1630 arg2Of Lys22,and
R1456 T1634 T1632 arg1Of degraded,to
R1457 T1634 T1633 arg2Of degraded,be
R1458 T1638 T1634 arg1Of proteasome,degraded
R1459 T1638 T1635 arg2Of proteasome,by
R1460 T1638 T1636 arg1Of proteasome,the
R1461 T1638 T1637 arg1Of proteasome,26S
R1462 T1638 T1639 arg1Of proteasome,(
R1463 T1640 T1639 arg2Of 6,(
R1464 T1641 T1639 arg3Of ),(
R1465 T1644 T1642 arg1Of activity,The
R1466 T1644 T1643 arg1Of activity,NF-κB
R1467 T1644 T1645 arg1Of activity,is
R1468 T1644 T1646 arg2Of activity,enhanced
R1469 T1646 T1645 arg2Of enhanced,is
R1470 T1646 T1647 arg1Of enhanced,by
R1471 T1646 T1651 arg1Of enhanced,at
R1472 T1648 T1647 arg2Of phosphorylation,by
R1473 T1648 T1649 arg1Of phosphorylation,of
R1474 T1650 T1649 arg2Of p65,of
R1475 T1652 T1651 arg2Of Ser276,at
R1476 T1654 T1655 arg1Of PKA,and
R1477 T1655 T1660 arg1Of and,","
R1478 T1656 T1655 arg2Of MSK1,and
R1479 T1656 T1657 arg1Of MSK1,(
R1480 T1658 T1657 arg2Of "7,8",(
R1481 T1659 T1657 arg3Of ),(
R1482 T1660 T1646 arg1Of ",",enhanced
R1483 T1660 T1653 arg2Of ",",by
R1484 T1660 T1662 arg1Of ",",by
R1485 T1661 T1660 arg2Of Ser311,","
R1486 T1663 T1664 arg1Of PKCζ,(
R1487 T1663 T1667 arg1Of PKCζ,and
R1488 T1665 T1664 arg2Of 9,(
R1489 T1666 T1664 arg3Of ),(
R1490 T1667 T1662 arg2Of and,by
R1491 T1667 T1669 arg1Of and,by
R1492 T1668 T1667 arg2Of Ser536,and
R1493 T1670 T1669 arg2Of IKKα,by
R1494 T1670 T1671 arg1Of IKKα,(
R1495 T1672 T1671 arg2Of "10,11",(
R1496 T1673 T1671 arg3Of ),(
R1497 T1674 T1675 arg1Of Acetylation,of
R1498 T1674 T1677 arg1Of Acetylation,at
R1499 T1674 T1681 arg1Of Acetylation,increases
R1500 T1674 T1686 arg1Of Acetylation,impairs
R1501 T1676 T1675 arg2Of p65,of
R1502 T1678 T1679 arg1Of Lys218,and
R1503 T1679 T1677 arg2Of and,at
R1504 T1680 T1679 arg2Of Lys221,and
R1505 T1681 T1685 arg1Of increases,and
R1506 T1684 T1681 arg2Of binding,increases
R1507 T1684 T1682 arg1Of binding,the
R1508 T1684 T1683 arg1Of binding,DNA
R1509 T1685 T1692 arg1Of and,and
R1510 T1686 T1685 arg2Of impairs,and
R1511 T1688 T1686 arg2Of association,impairs
R1512 T1688 T1687 arg1Of association,the
R1513 T1688 T1689 arg1Of association,with
R1514 T1690 T1689 arg2Of IκB-α,with
R1515 T1692 T1691 arg1Of and,","
R1516 T1693 T1694 arg1Of acetylation,at
R1517 T1693 T1696 arg1Of acetylation,enhances
R1518 T1695 T1694 arg2Of Lys310,at
R1519 T1696 T1692 arg2Of enhances,and
R1520 T1700 T1696 arg2Of activity,enhances
R1521 T1700 T1697 arg1Of activity,the
R1522 T1700 T1698 arg1Of activity,p65
R1523 T1700 T1699 arg1Of activity,transcriptional
R1524 T1700 T1701 arg1Of activity,(
R1525 T1702 T1701 arg2Of "12,13",(
R1526 T1703 T1701 arg3Of ),(
R1527 T1705 T1704 arg1Of turn,Post-activation
R1528 T1705 T1706 arg1Of turn,off
R1529 T1708 T1707 arg1Of NF-κB,of
R1530 T1708 T1709 arg1Of NF-κB,is
R1531 T1708 T1710 arg2Of NF-κB,regulated
R1532 T1710 T1705 arg2Of regulated,turn
R1533 T1710 T1709 arg2Of regulated,is
R1534 T1710 T1715 arg1Of regulated,through
R1535 T1714 T1710 arg1Of loop,regulated
R1536 T1714 T1711 arg2Of loop,by
R1537 T1714 T1712 arg1Of loop,negative
R1538 T1714 T1713 arg1Of loop,feedback
R1539 T1716 T1715 arg2Of inhibitors,through
R1540 T1716 T1717 arg1Of inhibitors,under
R1541 T1716 T1723 arg1Of inhibitors,","
R1542 T1716 T1725 arg1Of inhibitors,as
R1543 T1720 T1717 arg2Of control,under
R1544 T1720 T1718 arg1Of control,the
R1545 T1720 T1719 arg1Of control,transcriptional
R1546 T1720 T1721 arg1Of control,of
R1547 T1722 T1721 arg2Of NF-κB,of
R1548 T1725 T1724 arg1Of as,such
R1549 T1726 T1727 arg1Of IκB-α,and
R1550 T1728 T1727 arg2Of ubiquitin-editing,and
R1551 T1730 T1725 arg2Of A20,as
R1552 T1730 T1726 arg1Of A20,IκB-α
R1553 T1730 T1728 arg1Of A20,ubiquitin-editing
R1554 T1730 T1729 arg1Of A20,protein
R1555 T1730 T1731 arg1Of A20,(
R1556 T1732 T1731 arg2Of 14–20,(
R1557 T1733 T1731 arg3Of ),(
R1558 T1734 T1735 arg1Of Deacetylation,of
R1559 T1734 T1737 arg1Of Deacetylation,by
R1560 T1734 T1743 arg1Of Deacetylation,or
R1561 T1736 T1735 arg2Of p65,of
R1562 T1739 T1740 arg1Of deacetylase-3,or
R1563 T1740 T1737 arg2Of or,by
R1564 T1740 T1738 arg1Of or,histone
R1565 T1741 T1740 arg2Of SIRT1,or
R1566 T1743 T1742 arg1Of or,","
R1567 T1743 T1751 arg1Of or,down-regulate
R1568 T1744 T1743 arg2Of acetylation,or
R1569 T1744 T1745 arg1Of acetylation,of
R1570 T1744 T1747 arg1Of acetylation,at
R1571 T1746 T1745 arg2Of p65,of
R1572 T1748 T1749 arg1Of Lys122,and
R1573 T1749 T1747 arg2Of and,at
R1574 T1750 T1749 arg2Of Lys123,and
R1575 T1754 T1751 arg2Of activity,down-regulate
R1576 T1754 T1752 arg1Of activity,the
R1577 T1754 T1753 arg1Of activity,NF-κB
R1578 T1754 T1755 arg1Of activity,(
R1579 T1756 T1755 arg2Of "12,21,22",(
R1580 T1757 T1755 arg3Of ),(
R1581 T1759 T1758 arg1Of activation,Persistent
R1582 T1759 T1760 arg1Of activation,of
R1583 T1759 T1762 arg1Of activation,occurs
R1584 T1759 T1778 arg1Of activation,enhances
R1585 T1761 T1760 arg2Of NF-κB,of
R1586 T1762 T1763 arg1Of occurs,in
R1587 T1762 T1777 arg1Of occurs,and
R1588 T1766 T1764 arg1Of virus-1,human
R1589 T1766 T1765 arg1Of virus-1,immunodeficiency
R1590 T1766 T1767 arg1Of virus-1,(
R1591 T1768 T1767 arg2Of HIV-1,(
R1592 T1769 T1767 arg3Of ),(
R1593 T1771 T1772 arg1Of monocytes,","
R1594 T1772 T1774 arg1Of ",",and
R1595 T1773 T1772 arg2Of macrophages,","
R1596 T1774 T1763 arg2Of and,in
R1597 T1774 T1766 arg1Of and,virus-1
R1598 T1774 T1770 arg1Of and,-infected
R1599 T1775 T1774 arg2Of microglia,and
R1600 T1777 T1776 arg1Of and,","
R1601 T1778 T1777 arg2Of enhances,and
R1602 T1780 T1778 arg2Of expression,enhances
R1603 T1780 T1779 arg1Of expression,the
R1604 T1780 T1781 arg1Of expression,of
R1605 T1783 T1781 arg2Of genes,of
R1606 T1783 T1782 arg1Of genes,NF-κB-responsive
R1607 T1783 T1784 arg1Of genes,","
R1608 T1783 T1785 arg1Of genes,including
R1609 T1787 T1786 arg1Of cytokines,pro-inflammatory
R1610 T1787 T1788 arg1Of cytokines,","
R1611 T1788 T1792 arg1Of ",",and
R1612 T1791 T1788 arg2Of molecules,","
R1613 T1791 T1789 arg1Of molecules,cell
R1614 T1791 T1790 arg1Of molecules,adhesion
R1615 T1792 T1785 arg2Of and,including
R1616 T1793 T1792 arg2Of chemokines,and
R1617 T1793 T1794 arg1Of chemokines,(
R1618 T1795 T1794 arg2Of 23–25,(
R1619 T1796 T1794 arg3Of ),(
R1620 T1798 T1797 arg1Of inflammation,Chronic
R1621 T1798 T1799 arg1Of inflammation,is
R1622 T1799 T1808 arg1Of is,in
R1623 T1802 T1799 arg2Of cause,is
R1624 T1802 T1800 arg1Of cause,a
R1625 T1802 T1801 arg1Of cause,major
R1626 T1802 T1803 arg1Of cause,of
R1627 T1807 T1803 arg2Of dysfunction,of
R1628 T1807 T1804 arg1Of dysfunction,immune
R1629 T1807 T1805 arg1Of dysfunction,and
R1630 T1807 T1806 arg1Of dysfunction,neuron
R1631 T1809 T1808 arg2Of AIDS,in
R1632 T1809 T1810 arg1Of AIDS,(
R1633 T1811 T1810 arg2Of "26,27",(
R1634 T1812 T1810 arg3Of ),(
R1635 T1817 T1815 arg1Of hosts,non-human
R1636 T1817 T1816 arg1Of hosts,primate
R1637 T1817 T1818 arg1Of hosts,for
R1638 T1817 T1822 arg1Of hosts,","
R1639 T1817 T1824 arg1Of hosts,as
R1640 T1817 T1832 arg1Of hosts,lack
R1641 T1817 T1837 arg1Of hosts,do
R1642 T1817 T1839 arg1Of hosts,develop
R1643 T1821 T1818 arg2Of virus,for
R1644 T1821 T1819 arg1Of virus,simian
R1645 T1821 T1820 arg1Of virus,immunodeficiency
R1646 T1824 T1823 arg1Of as,such
R1647 T1827 T1825 arg1Of monkeys,African
R1648 T1827 T1826 arg1Of monkeys,green
R1649 T1827 T1828 arg1Of monkeys,and
R1650 T1828 T1824 arg2Of and,as
R1651 T1830 T1828 arg2Of mangabey,and
R1652 T1830 T1829 arg1Of mangabey,sooty
R1653 T1832 T1836 arg1Of lack,and
R1654 T1835 T1832 arg2Of activation,lack
R1655 T1835 T1833 arg1Of activation,aberrant
R1656 T1835 T1834 arg1Of activation,immune
R1657 T1836 T1813 arg1Of and,Consistently
R1658 T1836 T1814 arg1Of and,","
R1659 T1836 T1831 arg1Of and,","
R1660 T1839 T1836 arg2Of develop,and
R1661 T1839 T1837 arg2Of develop,do
R1662 T1839 T1838 arg1Of develop,not
R1663 T1839 T1841 arg1Of develop,despite
R1664 T1840 T1839 arg2Of AIDS,develop
R1665 T1844 T1841 arg2Of replication,despite
R1666 T1844 T1842 arg1Of replication,high
R1667 T1844 T1843 arg1Of replication,virus
R1668 T1844 T1845 arg1Of replication,(
R1669 T1846 T1845 arg2Of "28,29",(
R1670 T1847 T1845 arg3Of ),(
R1671 T1850 T1858 arg1Of understanding,may
R1672 T1850 T1859 arg1Of understanding,provide
R1673 T1852 T1850 arg2Of mechanisms,understanding
R1674 T1852 T1851 arg1Of mechanisms,the
R1675 T1852 T1853 arg1Of mechanisms,of
R1676 T1852 T1856 arg1Of mechanisms,by
R1677 T1855 T1853 arg2Of deregulation,of
R1678 T1855 T1854 arg1Of deregulation,NF-κB
R1679 T1857 T1856 arg2Of HIV-1,by
R1680 T1859 T1848 arg1Of provide,Thus
R1681 T1859 T1849 arg1Of provide,","
R1682 T1859 T1858 arg2Of provide,may
R1683 T1859 T1862 arg1Of provide,into
R1684 T1861 T1859 arg2Of insights,provide
R1685 T1861 T1860 arg1Of insights,further
R1686 T1864 T1862 arg2Of pathogenesis,into
R1687 T1864 T1863 arg1Of pathogenesis,AIDS
R1688 T1867 T1865 arg2Of entry,In
R1689 T1867 T1866 arg1Of entry,HIV-1
R1690 T1870 T1869 arg1Of binding,the
R1691 T1870 T1871 arg1Of binding,of
R1692 T1870 T1876 arg1Of binding,to
R1693 T1870 T1878 arg1Of binding,induces
R1694 T1875 T1871 arg2Of envelope,of
R1695 T1875 T1872 arg1Of envelope,the
R1696 T1875 T1873 arg1Of envelope,gp120
R1697 T1875 T1874 arg1Of envelope,viral
R1698 T1877 T1876 arg2Of CD4,to
R1699 T1878 T1865 arg1Of induces,In
R1700 T1878 T1868 arg1Of induces,","
R1701 T1878 T1882 arg1Of induces,by
R1702 T1881 T1878 arg2Of activity,induces
R1703 T1881 T1879 arg1Of activity,the
R1704 T1881 T1880 arg1Of activity,NF-κB
R1705 T1883 T1884 arg1Of activation,of
R1706 T1883 T1889 arg1Of activation,and
R1707 T1885 T1884 arg2Of IKK,of
R1708 T1885 T1886 arg1Of IKK,(
R1709 T1887 T1886 arg2Of 30,(
R1710 T1888 T1886 arg3Of ),(
R1711 T1889 T1882 arg2Of and,by
R1712 T1890 T1889 arg2Of procaspase,and
R1713 T1890 T1891 arg1Of procaspase,8
R1714 T1890 T1892 arg1Of procaspase,(
R1715 T1893 T1892 arg2Of 31,(
R1716 T1894 T1892 arg3Of ),(
R1717 T1897 T1895 arg2Of integration,Following
R1718 T1897 T1896 arg1Of integration,viral
R1719 T1904 T1899 arg1Of protein,the
R1720 T1904 T1900 arg1Of protein,early
R1721 T1904 T1901 arg2Of protein,encoded
R1722 T1904 T1902 arg1Of protein,HIV-1
R1723 T1904 T1903 arg1Of protein,Tat
R1724 T1904 T1905 arg1Of protein,interacts
R1725 T1904 T1915 arg1Of protein,sustain
R1726 T1905 T1895 arg1Of interacts,Following
R1727 T1905 T1898 arg1Of interacts,","
R1728 T1905 T1906 arg1Of interacts,with
R1729 T1909 T1908 arg1Of RNA,HIV-1
R1730 T1909 T1910 arg1Of RNA,and
R1731 T1910 T1906 arg2Of and,with
R1732 T1910 T1907 arg1Of and,the
R1733 T1913 T1910 arg2Of factors,and
R1734 T1913 T1911 arg1Of factors,host
R1735 T1913 T1912 arg1Of factors,cell
R1736 T1915 T1905 arg2Of sustain,interacts
R1737 T1915 T1914 arg1Of sustain,to
R1738 T1918 T1915 arg2Of replication,sustain
R1739 T1918 T1916 arg1Of replication,the
R1740 T1918 T1917 arg1Of replication,viral
R1741 T1919 T1920 arg1Of Tat,binds
R1742 T1920 T1921 arg1Of binds,to
R1743 T1920 T1964 modOf binds,to
R1744 T1924 T1922 arg1Of structures,RNA
R1745 T1924 T1923 arg1Of structures,stem-loop
R1746 T1924 T1925 arg2Of structures,generated
R1747 T1924 T1933 arg1Of structures,","
R1748 T1924 T1934 arg1Of structures,including
R1749 T1924 T1945 arg1Of structures,","
R1750 T1925 T1926 arg1Of generated,by
R1751 T1929 T1926 arg2Of end,by
R1752 T1992 T1991 arg2Of TFIID,","
R1753 T1992 T1993 arg1Of TFIID,(
R1754 T1994 T1993 arg2Of 36,(
R1755 T1929 T1927 arg1Of end,the
R1756 T1995 T1993 arg3Of ),(
R1757 T1996 T2001 arg1Of ",",","
R1758 T1929 T1928 arg1Of end,5′
R1759 T1997 T1996 arg2Of E2F-4,","
R1760 T1997 T1998 arg1Of E2F-4,(
R1761 T1929 T1930 arg1Of end,of
R1762 T1932 T1930 arg2Of transcripts,of
R1763 T1999 T1998 arg2Of 37,(
R1764 T2000 T1998 arg3Of ),(
R1765 T2001 T1986 arg2Of ",",as
R1766 T1932 T1931 arg1Of transcripts,target
R1767 T2002 T2003 arg1Of C/EBPβ,(
R1768 T2002 T2006 arg1Of C/EBPβ,","
R1769 T1938 T1934 arg2Of element,including
R1770 T2004 T2003 arg2Of 38,(
R1771 T2005 T2003 arg3Of ),(
R1772 T2006 T2012 arg1Of ",",and
R1773 T2008 T2006 arg2Of T1/CDK9,","
R1774 T2008 T2007 arg1Of T1/CDK9,cyclin
R1775 T2008 T2009 arg1Of T1/CDK9,(
R1776 T2010 T2009 arg2Of "39,40",(
R1777 T2011 T2009 arg3Of ),(
R1778 T2012 T2001 arg2Of and,","
R1779 T1938 T1935 arg1Of element,the
R1780 T1938 T1936 arg1Of element,HIV-1
R1781 T1938 T1937 arg1Of element,transactivation-responsive
R1782 T2015 T2013 arg1Of acetyltransferases,the
R1783 T2015 T2014 arg1Of acetyltransferases,histone
R1784 T2016 T2015 arg1Of p300/CBP,acetyltransferases
R1785 T2016 T2017 arg1Of p300/CBP,and
R1786 T1938 T1939 arg1Of element,(
R1787 T2017 T2012 arg2Of and,and
R1788 T1938 T1942 arg1Of element,(
R1789 T2018 T2017 arg2Of P/CAF,and
R1790 T2018 T2019 arg1Of P/CAF,(
R1791 T1940 T1939 arg2Of TAR,(
R1792 T2020 T2019 arg2Of 41–43,(
R1793 T2021 T2019 arg3Of ),(
R1794 T2023 T2024 arg1Of released,from
R1795 T2026 T2024 arg2Of cells,from
R1796 T2026 T2025 arg1Of cells,HIV-1-infected
R1797 T1941 T1939 arg3Of ),(
R1798 T2028 T2029 arg1Of Tat,deregulates
R1799 T2028 T2034 arg1Of Tat,binding
R1800 T2029 T2022 arg1Of deregulates,When
R1801 T2029 T2023 modOf deregulates,released
R1802 T2029 T2027 arg1Of deregulates,","
R1803 T2029 T2033 arg1Of deregulates,by
R1804 T1943 T1942 arg2Of 32,(
R1805 T2032 T2029 arg2Of signaling,deregulates
R1806 T2032 T2030 arg1Of signaling,the
R1807 T2032 T2031 arg1Of signaling,cell
R1808 T2034 T2033 arg2Of binding,by
R1809 T2034 T2035 arg1Of binding,to
R1810 T1944 T1942 arg3Of ),(
R1811 T2037 T2035 arg2Of receptors,to
R1812 T2037 T2036 arg1Of receptors,cell
R1813 T2037 T2038 arg1Of receptors,","
R1814 T2037 T2040 arg1Of receptors,as
R1815 T1945 T1953 arg1Of ",",(
R1816 T2040 T2039 arg1Of as,such
R1817 T2041 T2042 arg1Of integrins,(
R1818 T2041 T2045 arg1Of integrins,","
R1819 T1945 T1956 arg1Of ",",and
R1820 T2043 T2042 arg2Of 44,(
R1821 T2044 T2042 arg3Of ),(
R1822 T1949 T1945 arg2Of β,","
R1823 T2045 T2051 arg1Of ",",and
R1824 T2047 T2045 arg2Of receptor,","
R1825 T2047 T2046 arg1Of receptor,Flk1/KDR
R1826 T2047 T2048 arg1Of receptor,(
R1827 T2049 T2048 arg2Of 45,(
R1828 T2050 T2048 arg3Of ),(
R1829 T2051 T2040 arg2Of and,as
R1830 T1949 T1946 arg1Of β,tumor
R1831 T1949 T1947 arg1Of β,necrosis
R1832 T2053 T2051 arg2Of receptors,and
R1833 T2053 T2052 arg1Of receptors,chemokine
R1834 T2053 T2054 arg1Of receptors,(
R1835 T1949 T1948 arg1Of β,factor
R1836 T2055 T2054 arg2Of 46,(
R1837 T1949 T1950 arg1Of β,(
R1838 T1951 T1950 arg2Of TNFβ,(
R1839 T2056 T2054 arg3Of ),(
R1840 T2057 T2059 arg1Of We,reported
R1841 T2059 T2058 arg1Of reported,first
R1842 T1952 T1950 arg3Of ),(
R1843 T2061 T2062 arg1Of NF-κB,was
R1844 T2061 T2064 arg1Of NF-κB,active
R1845 T2062 T2059 arg2Of was,reported
R1846 T2062 T2060 arg1Of was,that
R1847 T2064 T2062 arg2Of active,was
R1848 T2064 T2063 arg1Of active,constitutively
R1849 T2064 T2065 arg1Of active,in
R1850 T2067 T2065 arg2Of cells,in
R1851 T2067 T2066 arg1Of cells,Jurkat
R1852 T2067 T2068 arg1Of cells,that
R1853 T2067 T2070 arg1Of cells,expressed
R1854 T1954 T1953 arg2Of 33,(
R1855 T2070 T2069 arg1Of expressed,stably
R1856 T1955 T1953 arg3Of ),(
R1857 T1956 T1921 arg2Of and,to
R1858 T2073 T2070 arg2Of gene,expressed
R1859 T2073 T2071 arg1Of gene,the
R1860 T2073 T2072 arg1Of gene,Tat
R1861 T2073 T2074 arg1Of gene,(
R1862 T1956 T1961 arg1Of and,(
R1863 T2075 T2074 arg2Of 47,(
R1864 T1957 T1956 arg2Of interleukin-6,and
R1865 T2076 T2074 arg3Of ),(
R1866 T1957 T1958 arg1Of interleukin-6,(
R1867 T1959 T1958 arg2Of IL-6,(
R1868 T2079 T2078 arg1Of transfection,gene
R1869 T2079 T2080 arg1Of transfection,or
R1870 T2080 T2077 arg2Of or,Following
R1871 T1960 T1958 arg3Of ),(
R1872 T2082 T2080 arg2Of transduction,or
R1873 T2082 T2081 arg1Of transduction,protein
R1874 T2084 T2085 arg1Of Tat,induced
R1875 T1962 T1961 arg2Of 34,(
R1876 T2084 T2099 arg1Of Tat,increased
R1877 T2084 T2105 arg1Of Tat,inhibiting
R1878 T2085 T2098 arg1Of induced,and
R1879 T1963 T1961 arg3Of ),(
R1880 T2088 T2087 arg1Of activity,IKK
R1881 T2088 T2089 arg1Of activity,and
R1882 T1965 T1964 arg1Of activate,to
R1883 T1967 T1965 arg2Of transcription,activate
R1884 T2089 T2085 arg2Of and,induced
R1885 T2089 T2086 arg1Of and,the
R1886 T2089 T2092 arg1Of and,of
R1887 T1967 T1966 arg1Of transcription,gene
R1888 T2091 T2089 arg2Of degradation,and
R1889 T2091 T2090 arg1Of degradation,proteasomal
R1890 T1970 T1971 arg1Of Tat,promotes
R1891 T2093 T2092 arg2Of IκB-α,of
R1892 T2093 T2094 arg1Of IκB-α,(
R1893 T2095 T2094 arg2Of 48,(
R1894 T2096 T2094 arg3Of ),(
R1895 T2098 T2077 arg1Of and,Following
R1896 T2098 T2083 arg1Of and,","
R1897 T2098 T2097 arg1Of and,","
R1898 T2099 T2098 arg2Of increased,and
R1899 T2099 T2104 arg1Of increased,by
R1900 T1970 T1978 arg1Of Tat,interacting
R1901 T1971 T1968 arg1Of promotes,Indeed
R1902 T2103 T2099 arg2Of activity,increased
R1903 T2103 T2100 arg1Of activity,the
R1904 T2103 T2101 arg1Of activity,p65
R1905 T2103 T2102 arg1Of activity,transcriptional
R1906 T2105 T2104 arg2Of inhibiting,by
R1907 T1971 T1969 arg1Of promotes,","
R1908 T1971 T1977 arg1Of promotes,by
R1909 T2108 T2105 arg2Of deacetylation,inhibiting
R1910 T2108 T2106 arg1Of deacetylation,the
R1911 T2108 T2107 arg1Of deacetylation,SIRT-1-mediated
R1912 T2108 T2109 arg1Of deacetylation,of
R1913 T1974 T1972 arg1Of initiation,the
R1914 T2111 T2109 arg2Of Lys310,of
R1915 T2111 T2110 arg1Of Lys310,p65
R1916 T2111 T2112 arg1Of Lys310,(
R1917 T2113 T2112 arg2Of 49,(
R1918 T2114 T2112 arg3Of ),(
R1919 T1974 T1973 arg1Of initiation,transcriptional
R1920 T1974 T1975 arg1Of initiation,and
R1921 T2116 T2115 arg1Of findings,These
R1922 T2116 T2117 arg1Of findings,suggested
R1923 T2117 T2127 arg1Of suggested,;
R1924 T1975 T1971 arg2Of and,promotes
R1925 T2119 T2120 arg1Of Tat,modulates
R1926 T2120 T2117 arg2Of modulates,suggested
R1927 T2120 T2118 arg1Of modulates,that
R1928 T1976 T1975 arg2Of elongation,and
R1929 T2122 T2120 arg2Of enzymes,modulates
R1930 T2122 T2121 arg1Of enzymes,crucial
R1931 T2122 T2123 arg2Of enzymes,involved
R1932 T2123 T2124 arg1Of involved,in
R1933 T1978 T1977 arg2Of interacting,by
R1934 T2126 T2124 arg2Of signaling,in
R1935 T2126 T2125 arg1Of signaling,NF-κB
R1936 T1978 T1979 arg1Of interacting,with
R1937 T1981 T1982 arg1Of factors,and
R1938 T2131 T2127 arg2Of was,;
R1939 T2131 T2128 arg1Of was,however
R1940 T2131 T2129 arg1Of was,","
R1941 T2132 T2131 arg2Of unclear,was
R1942 T2133 T2130 arg1Of how,it
R1943 T2133 T2131 arg1Of how,was
R1944 T2133 T2132 arg1Of how,unclear
R1945 T2134 T2135 arg1Of Tat,could
R1946 T2134 T2136 arg1Of Tat,subvert
R1947 T2136 T2133 arg1Of subvert,how
R1948 T2136 T2135 arg2Of subvert,could
R1949 T2139 T2136 arg2Of feedback,subvert
R1950 T2139 T2137 arg1Of feedback,the
R1951 T2139 T2138 arg1Of feedback,negative
R1952 T2139 T2140 arg1Of feedback,of
R1953 T2139 T2142 arg1Of feedback,","
R1954 T2139 T2143 arg1Of feedback,which
R1955 T2139 T2144 arg1Of feedback,is
R1956 T2139 T2146 arg1Of feedback,dependent
R1957 T2141 T2140 arg2Of NF-κB,of
R1958 T1982 T1979 arg2Of and,with
R1959 T1982 T1980 arg1Of and,transacting
R1960 T2146 T2144 arg2Of dependent,is
R1961 T2146 T2145 arg1Of dependent,mainly
R1962 T2146 T2147 arg1Of dependent,on
R1963 T1982 T1984 arg1Of and,","
R1964 T1982 T1986 arg1Of and,as
R1965 T1983 T1982 arg2Of cofactors,and
R1966 T1986 T1985 arg1Of as,such
R1967 T2149 T2148 arg1Of novo,de
R1968 T2150 T2147 arg2Of synthesis,on
R1969 T2150 T2149 arg1Of synthesis,novo
R1970 T2150 T2151 arg1Of synthesis,of
R1971 T2152 T2151 arg2Of IκB-α,of
R1972 T2152 T2153 arg1Of IκB-α,(
R1973 T1987 T1988 arg1Of Sp1,(
R1974 T2154 T2153 arg2Of "15,17",(
R1975 T2155 T2153 arg3Of ),(
R1976 T1987 T1991 arg1Of Sp1,","
R1977 T2156 T2158 arg1Of We,found
R1978 T1989 T1988 arg2Of 35,(
R1979 T2158 T2157 arg1Of found,previously
R1980 T2160 T2161 arg1Of IκB-α,binds
R1981 T2160 T2165 arg1Of IκB-α,promotes
R1982 T1990 T1988 arg3Of ),(
R1983 T2161 T2162 arg1Of binds,to
R1984 T2161 T2164 arg1Of binds,and
R1985 T2163 T2162 arg2Of Tat,to
R1986 T1991 T1996 arg1Of ",",","
R1987 T2164 T2158 arg2Of and,found
R1988 T2164 T2159 arg1Of and,that
R1989 T2165 T2164 arg2Of promotes,and
R1990 T2187 T2184 arg2Of turn,counteracts
R1991 T2168 T2165 arg2Of export,promotes
R1992 T2168 T2166 arg1Of export,the
R1993 T2168 T2167 arg1Of export,nuclear
R1994 T2168 T2169 arg1Of export,of
R1995 T2172 T2169 arg2Of transactivator,of
R1996 T2172 T2170 arg1Of transactivator,the
R1997 T2172 T2171 arg1Of transactivator,viral
R1998 T2172 T2173 arg1Of transactivator,(
R1999 T2174 T2173 arg2Of "50,51",(
R2000 T2175 T2173 arg3Of ),(
R2001 T2178 T2176 arg2Of study,In
R2002 T2178 T2177 arg1Of study,this
R2003 T2187 T2185 arg1Of turn,the
R2004 T2180 T2181 arg1Of we,report
R2005 T2187 T2186 arg1Of turn,post-activation
R2006 T2181 T2176 arg1Of report,In
R2007 T2181 T2179 arg1Of report,","
R2008 T2183 T2184 arg1Of Tat,counteracts
R2009 T2188 T2189 arg1Of off,of
R2010 T2184 T2181 arg2Of counteracts,report
R2011 T2184 T2182 arg1Of counteracts,that
R2012 T2184 T2188 arg1Of counteracts,off
R2013 T2184 T2191 arg1Of counteracts,through
R2014 T2190 T2189 arg2Of NF-κB,of
R2015 T2193 T2191 arg2Of interaction,through
R2016 T2193 T2192 arg1Of interaction,direct
R2017 T2193 T2194 arg1Of interaction,with
R2018 T2193 T2198 arg1Of interaction,","
R2019 T2193 T2199 arg1Of interaction,which
R2020 T2193 T2200 arg1Of interaction,enhances
R2021 T2195 T2196 arg1Of IκB-α,and
R2028 T2196 T2194 arg2Of and,with
R2029 T2197 T2196 arg2Of p65,and
R2033 T2203 T2202 arg1Of binding,DNA
R2035 T2203 T2204 arg1Of binding,and
R2036 T2205 T2204 arg2Of transcriptional,and
R2037 T2206 T2200 arg2Of activity,enhances
R2038 T2206 T2201 arg1Of activity,the
R2039 T2206 T2203 arg1Of activity,binding
R2040 T2206 T2205 arg1Of activity,transcriptional
R2041 T2206 T2207 arg1Of activity,of
R2042 T2210 T2207 arg2Of complex,of
R2043 T2210 T2208 arg1Of complex,the
R2044 T2210 T2209 arg1Of complex,NF-κB
R2045 T2213 T2211 arg1Of mechanism,The
R2046 T2213 T2212 arg1Of mechanism,new
R2047 T2213 T2214 arg1Of mechanism,of
R2048 T2213 T2219 arg1Of mechanism,may
R2049 T2213 T2220 arg1Of mechanism,provide
R2050 T2216 T2214 arg2Of deregulation,of
R2051 T2216 T2215 arg1Of deregulation,NF-κB
R2052 T2216 T2217 arg1Of deregulation,here
R2053 T2216 T2218 arg2Of deregulation,described
R2054 T2220 T2219 arg2Of provide,may
R2055 T2220 T2223 arg1Of provide,into
R2056 T2222 T2220 arg2Of insights,provide
R2057 T2222 T2221 arg1Of insights,further
R2058 T2227 T2223 arg2Of activation,into
R2059 T2227 T2224 arg1Of activation,the
R2060 T2227 T2225 arg1Of activation,chronic
R2061 T2227 T2226 arg1Of activation,immune
R2062 T2227 T2228 arg1Of activation,of
R2063 T2230 T2228 arg2Of infection,of
R2064 T2230 T2229 arg1Of infection,HIV-1
R4014 T4416 T4417 arg1Of pcDNA-3xHA-IκB-α,","
R4015 T4417 T4419 arg1Of ",",","
R4016 T4418 T4417 arg2Of p3xFLAG-CMV-Tat,","
R4017 T4419 T4415 arg1Of ",",plasmids
R4018 T4419 T4426 arg1Of ",",","
R4019 T4423 T4422 arg2Of "22,25,27",(
R4020 T4424 T4422 arg3Of ),(
R4021 T4425 T4419 arg2Of A,","
R4022 T4425 T4420 arg1Of A,p3xFLAG-CMV-Tat
R4023 T4425 T4421 arg1Of A,C
R4024 T4425 T4422 arg1Of A,(
R4025 T4426 T4433 arg1Of ",",","
R4026 T4430 T4429 arg2Of "49,52,53,55,56,57",(
R4027 T4431 T4429 arg3Of ),(
R4028 T4432 T4426 arg2Of A,","
R4029 T4432 T4427 arg1Of A,p3xFLAG-CMV-Tat
R4030 T4432 T4428 arg1Of A,R
R4031 T4432 T4429 arg1Of A,(
R4032 T4433 T4435 arg1Of ",",","
R4033 T4434 T4433 arg2Of pGEX-2T-Tat,","
R4034 T4435 T4442 arg1Of ",",and
R4035 T4439 T4438 arg2Of "22,25,27",(
R4036 T4440 T4438 arg3Of ),(
R4037 T4441 T4435 arg2Of A,","
R4038 T4441 T4436 arg1Of A,pGEX-2T-Tat
R4039 T4441 T4437 arg1Of A,C
R4040 T4441 T4438 arg1Of A,(
R4041 T4442 T4414 arg1Of and,The
R4042 T4442 T4449 arg1Of and,were
R4043 T4442 T4451 arg2Of and,described
R4044 T4446 T4445 arg2Of "49,52,53,55,56,57",(
R4045 T4447 T4445 arg3Of ),(
R4046 T4448 T4442 arg2Of A,and
R4047 T4448 T4443 arg1Of A,pGEX-2T-Tat
R4048 T4448 T4444 arg1Of A,R
R4049 T4448 T4445 arg1Of A,(
R4050 T4451 T4449 arg2Of described,were
R4051 T4451 T4450 arg1Of described,previously
R4052 T4451 T4452 arg1Of described,(
R4053 T4453 T4452 arg2Of 50,(
R4054 T4454 T4452 arg3Of ),(
R4055 T4457 T4458 arg1Of pNL4-3.Luc.R-E-,and
R4056 T4458 T4455 arg1Of and,The
R4057 T4458 T4456 arg1Of and,plasmids
R4058 T4458 T4460 arg1Of and,were
R4059 T4458 T4461 arg2Of and,obtained
R4060 T4459 T4458 arg2Of pHXB2-env,and
R4061 T4461 T4460 arg2Of obtained,were
R4062 T4461 T4462 arg1Of obtained,from
R4063 T4461 T4480 arg1Of obtained,;
R4064 T4469 T4462 arg2Of Program,from
R4065 T4469 T4463 arg1Of Program,the
R4066 T4469 T4464 arg1Of Program,AIDS
R4067 T4469 T4465 arg1Of Program,Research
R4068 T4469 T4466 arg1Of Program,&
R4069 T4469 T4467 arg1Of Program,Reference
R4070 T4469 T4468 arg1Of Program,Reagent
R4071 T4469 T4470 arg1Of Program,","
R4072 T4469 T4478 arg1Of Program,","
R4073 T4471 T4470 arg2Of Division,","
R4074 T4471 T4472 arg1Of Division,of
R4075 T4473 T4474 arg1Of AIDS,","
R4076 T4474 T4476 arg1Of ",",","
R4077 T4475 T4474 arg2Of NIAID,","
R4078 T4476 T4472 arg2Of ",",of
R4079 T4477 T4476 arg2Of NIH,","
R4080 T4479 T4478 arg2Of USA,","
R4081 T4481 T4482 arg1Of pκBluc,and
R4082 T4482 T4484 arg1Of and,were
R4083 T4482 T4485 arg2Of and,purchased
R4084 T4483 T4482 arg2Of pSV-β-Gal,and
R4085 T4485 T4480 arg2Of purchased,;
R4086 T4485 T4484 arg2Of purchased,were
R4087 T4485 T4486 arg1Of purchased,from
R4088 T4487 T4486 arg2Of Promega,from
R4089 T4487 T4488 arg1Of Promega,(
R4090 T4489 T4490 arg1Of Madison,","
R4091 T4490 T4488 arg2Of ",",(
R4092 T4490 T4492 arg1Of ",",","
R4093 T4491 T4490 arg2Of WI,","
R4094 T4493 T4492 arg2Of USA,","
R4095 T4494 T4488 arg3Of ),(
R4096 T4497 T4498 arg1Of pRc/CMV-3xHA-p65,","
R4097 T4498 T4496 arg1Of ",",plasmids
R4098 T4498 T4503 arg1Of ",",","
R4099 T4499 T4498 arg2Of pRc/CMV-3xHA-p65ΔC,","
R4100 T4499 T4500 arg1Of pRc/CMV-3xHA-p65ΔC,(
R4101 T4501 T4500 arg2Of 1–318,(
R4102 T4502 T4500 arg3Of ),(
R4103 T4503 T4508 arg1Of ",",","
R4104 T4504 T4503 arg2Of pRc/CMV-3xHA-p65ΔN,","
R4105 T4504 T4505 arg1Of pRc/CMV-3xHA-p65ΔN,(
R4106 T4506 T4505 arg2Of 122–551,(
R4107 T4507 T4505 arg3Of ),(
R4108 T4508 T4511 arg1Of ",",","
R4109 T4510 T4508 arg2Of T,","
R4110 T4510 T4509 arg1Of T,p3xFLAG-CMV-Tat
R4111 T4511 T4517 arg1Of ",",","
R4112 T4514 T4513 arg2Of "23,24",(
R4113 T4515 T4513 arg3Of ),(
R4114 T4516 T4511 arg2Of A,","
R4115 T4516 T4512 arg1Of A,N
R4116 T4516 T4513 arg1Of A,(
R4117 T4517 T4495 arg1Of ",",The
R4118 T4517 T4542 arg1Of ",",were
R4119 T4517 T4543 arg2Of ",",generated
R4120 T4521 T4520 arg2Of "50,51",(
R4121 T4522 T4520 arg3Of ),(
R4122 T4523 T4518 arg1Of A,p3xFLAG-CMV-Tat
R4123 T4523 T4519 arg1Of A,K
R4124 T4523 T4520 arg1Of A,(
R4125 T4523 T4524 arg1Of A,","
R4126 T4524 T4527 arg1Of ",",","
R4127 T4526 T4524 arg2Of T,","
R4128 T4526 T4525 arg1Of T,pGEX-2T-Tat
R4129 T4527 T4533 arg1Of ",",","
R4130 T4530 T4529 arg2Of "23,24",(
R4131 T4531 T4529 arg3Of ),(
R4132 T4532 T4527 arg2Of A,","
R4133 T4532 T4528 arg1Of A,N
R4134 T4532 T4529 arg1Of A,(
R4135 T4533 T4540 arg1Of ",",and
R4136 T4537 T4536 arg2Of "50,51",(
R4137 T4538 T4536 arg3Of ),(
R4138 T4539 T4533 arg2Of A,","
R4139 T4539 T4534 arg1Of A,pGEX-2T-Tat
R4140 T4539 T4535 arg1Of A,K
R4141 T4539 T4536 arg1Of A,(
R4142 T4540 T4517 arg2Of and,","
R4143 T4541 T4540 arg2Of pNL4-3.FLAG-Tat.R-E-,and
R4144 T4543 T4542 arg2Of generated,were
R4145 T4543 T4544 arg1Of generated,as
R4146 T4545 T4544 arg2Of described,as
R4147 T4545 T4546 arg1Of described,in
R4148 T4548 T4546 arg2Of Data,in
R4149 T4548 T4547 arg1Of Data,Supplementary
R4308 T4915 T4916 arg1Of Cells,","
R4309 T4916 T4918 arg1Of ",",","
R4310 T4917 T4916 arg2Of transfection,","
R4311 T4918 T4920 arg1Of ",",and
R4312 T4919 T4918 arg2Of treatments,","
R4313 T4922 T4920 arg2Of assay,and
R4314 T4922 T4921 arg1Of assay,luciferase
R4315 T4923 T4924 arg1Of HeLa,","
R4316 T4925 T4924 arg2Of p50−/−p65−/−,","
R4317 T4928 T4923 arg1Of fibroblasts,HeLa
R4318 T4928 T4925 arg1Of fibroblasts,p50−/−p65−/−
R4319 T4928 T4926 arg1Of fibroblasts,mouse
R4320 T4928 T4927 arg1Of fibroblasts,embryonic
R4321 T4928 T4929 arg1Of fibroblasts,(
R4322 T4928 T4932 arg1Of fibroblasts,(
R4323 T4928 T4935 arg1Of fibroblasts,and
R4324 T4930 T4929 arg2Of MEFs,(
R4325 T4931 T4929 arg3Of ),(
R4326 T4933 T4932 arg2Of 52,(
R4327 T4934 T4932 arg3Of ),(
R4328 T4935 T4938 arg1Of and,were
R4329 T4935 T4939 arg2Of and,cultured
R4330 T4937 T4935 arg2Of cells,and
R4331 T4937 T4936 arg1Of cells,293T
R4332 T4939 T4938 arg2Of cultured,were
R4333 T4939 T4940 arg1Of cultured,in
R4334 T4939 T4947 arg1Of cultured,;
R4335 T4941 T4942 arg2Of Dulbecco,'s
R4336 T4944 T4942 arg1Of Eagle,'s
R4337 T4944 T4943 arg2Of Eagle,modified
R4338 T4944 T4945 arg2Of Eagle,'s
R4339 T4946 T4940 arg2Of medium,in
R4340 T4946 T4945 arg1Of medium,'s
R4341 T4948 T4949 arg1Of Jurkat,","
R4342 T4949 T4952 arg1Of ",",and
R4343 T4951 T4949 arg2Of cells,","
R4344 T4951 T4950 arg1Of cells,U937
R4345 T4952 T4958 arg1Of and,(
R4346 T4952 T4961 arg1Of and,were
R4347 T4952 T4962 arg2Of and,cultured
R4348 T4957 T4952 arg2Of cells,and
R4349 T4957 T4953 arg1Of cells,human
R4350 T4957 T4954 arg1Of cells,peripheral
R4351 T4957 T4955 arg1Of cells,blood
R4352 T4957 T4956 arg1Of cells,mononuclear
R4353 T4959 T4958 arg2Of PBMCs,(
R4354 T4960 T4958 arg3Of ),(
R4355 T4962 T4938 modOf cultured,were
R4356 T4962 T4961 arg2Of cultured,were
R4357 T4962 T4963 arg1Of cultured,in
R4358 T4964 T4963 arg2Of RPMI,in
R4359 T4964 T4965 arg1Of RPMI,1640
R4360 T4966 T4967 arg1Of PBMCs,were
R4361 T4966 T4968 arg2Of PBMCs,isolated
R4362 T4968 T4967 arg2Of isolated,were
R4363 T4968 T4969 arg1Of isolated,as
R4364 T4971 T4969 arg2Of described,as
R4365 T4971 T4970 arg1Of described,previously
R4366 T4971 T4972 arg1Of described,(
R4367 T4973 T4972 arg2Of 53,(
R4368 T4974 T4972 arg3Of ),(
R4369 T4975 T4976 arg1Of Media,were
R4370 T4975 T4977 arg2Of Media,supplemented
R4371 T4977 T4976 arg2Of supplemented,were
R4372 T4977 T4978 arg1Of supplemented,with
R4373 T4979 T4980 arg1Of 10,%
R4374 T4984 T4981 arg1Of serum,heat-inactivated
R4375 T4984 T4982 arg1Of serum,fetal
R4376 T4984 T4983 arg1Of serum,calf
R4377 T4984 T4985 arg1Of serum,and
R4378 T4985 T4978 arg2Of and,with
R4379 T4985 T4979 arg1Of and,10
R4380 T4985 T4988 arg1Of and,(
R4381 T4987 T4985 arg2Of l-glutamine,and
R4382 T4987 T4986 arg1Of l-glutamine,2 mM
R4383 T4991 T4988 arg2Of AG,(
R4384 T4991 T4989 arg1Of AG,Lonza
R4385 T4991 T4990 arg1Of AG,Cologne
R4386 T4991 T4992 arg1Of AG,","
R4387 T4993 T4992 arg2Of Germany,","
R4388 T4994 T4988 arg3Of ),(
R4389 T4995 T4996 arg1Of HeLa,","
R4390 T4996 T4999 arg1Of ",",and
R4391 T4998 T4996 arg2Of MEFs,","
R4392 T4998 T4997 arg1Of MEFs,p50−/−p65−/−
R4393 T4999 T5001 arg1Of and,were
R4394 T4999 T5002 arg2Of and,transfected
R4395 T5000 T4999 arg2Of 293T,and
R4396 T5002 T5001 arg2Of transfected,were
R4397 T5002 T5003 arg1Of transfected,with
R4398 T5002 T5005 arg1Of transfected,by
R4399 T5002 T5018 arg1Of transfected,","
R4400 T5002 T5019 arg1Of transfected,according
R4401 T5002 T5025 arg1Of transfected,;
R4402 T5004 T5003 arg2Of DNA,with
R4403 T5006 T5005 arg2Of using,by
R4404 T5008 T5006 arg2Of HD,using
R4405 T5008 T5007 arg1Of HD,FuGENE
R4406 T5008 T5009 arg1Of HD,(
R4407 T5012 T5009 arg2Of GmbH,(
R4408 T5012 T5010 arg1Of GmbH,Roche
R4409 T5012 T5011 arg1Of GmbH,Diagnostic
R4410 T5012 T5013 arg1Of GmbH,","
R4411 T5014 T5013 arg2Of Mannheim,","
R4412 T5014 T5015 arg1Of Mannheim,","
R4413 T5016 T5015 arg2Of Germany,","
R4414 T5017 T5009 arg3Of ),(
R4415 T5020 T5019 arg2Of to,according
R4416 T5023 T5020 arg2Of 's,to
R4417 T5023 T5021 arg1Of 's,the
R4418 T5023 T5022 arg1Of 's,manufacturer
R4419 T5023 T5024 arg1Of 's,protocol
R4420 T5028 T5026 arg1Of amounts,total
R4421 T5028 T5027 arg1Of amounts,DNA
R4422 T5028 T5029 arg1Of amounts,were
R4423 T5028 T5030 arg2Of amounts,equalized
R4424 T5030 T5025 arg2Of equalized,;
R4425 T5030 T5029 arg2Of equalized,were
R4426 T5032 T5030 arg1Of transfection,equalized
R4427 T5032 T5031 arg2Of transfection,by
R4428 T5032 T5033 arg1Of transfection,of
R4429 T5036 T5033 arg2Of vector,of
R4430 T5036 T5034 arg1Of vector,pRc/CMV
R4431 T5036 T5035 arg1Of vector,empty
R4432 T5036 T5037 arg1Of vector,(
R4433 T5038 T5037 arg2Of Invitrogen,(
R4434 T5038 T5039 arg1Of Invitrogen,","
R4435 T5038 T5043 arg1Of Invitrogen,","
R4436 T5038 T5044 arg1Of Invitrogen,USA
R4437 T5040 T5041 arg1Of Carlsbad,","
R4438 T5041 T5039 arg2Of ",",","
R4439 T5042 T5041 arg2Of CA,","
R4440 T5045 T5037 arg3Of ),(
R4441 T5047 T5046 arg2Of pulse-stimulation,For
R4442 T5050 T5049 arg1Of cells,HeLa
R4443 T5050 T5051 arg1Of cells,were
R4444 T5050 T5052 arg2Of cells,treated
R4445 T5050 T5098 arg1Of cells,returned
R4446 T5052 T5051 arg2Of treated,were
R4447 T5052 T5053 arg1Of treated,with
R4448 T5052 T5096 arg1Of treated,and
R4449 T5056 T5054 arg1Of 13-acetate,phorbol
R4450 T5056 T5055 arg1Of 13-acetate,12-myristate
R4451 T5056 T5057 arg1Of 13-acetate,(
R4452 T5056 T5069 arg1Of 13-acetate,(
R4453 T5056 T5072 arg1Of 13-acetate,for
R4454 T5056 T5075 arg1Of 13-acetate,or
R4455 T5058 T5057 arg2Of PMA,(
R4456 T5058 T5059 arg1Of PMA,;
R4457 T5060 T5059 arg2Of Sigma-Aldrich,;
R4458 T5060 T5061 arg1Of Sigma-Aldrich,","
R4459 T5060 T5066 arg1Of Sigma-Aldrich,","
R4460 T5060 T5067 arg1Of Sigma-Aldrich,USA
R4461 T5063 T5061 arg2Of Louis,","
R4462 T5063 T5062 arg1Of Louis,St
R4463 T5063 T5064 arg1Of Louis,","
R4464 T5065 T5064 arg2Of MO,","
R4465 T5068 T5057 arg3Of ),(
R4466 T5070 T5069 arg2Of 20 ng/ml,(
R4467 T5071 T5069 arg3Of ),(
R4468 T5073 T5072 arg2Of 5 min,for
R4469 T5075 T5053 arg2Of or,with
R4470 T5075 T5074 arg1Of or,","
R4471 T5078 T5075 arg2Of factor-α,or
R4472 T5078 T5076 arg1Of factor-α,tumor
R4473 T5078 T5077 arg1Of factor-α,necrosis
R4474 T5078 T5079 arg1Of factor-α,(
R4475 T5078 T5084 arg1Of factor-α,(
R4476 T5078 T5087 arg1Of factor-α,for
R4477 T5078 T5089 arg1Of factor-α,","
R4478 T5078 T5090 arg2Of factor-α,washed
R4479 T5080 T5079 arg2Of TNF-α,(
R4480 T5080 T5081 arg1Of TNF-α,;
R4481 T5080 T5082 arg1Of TNF-α,Sigma-Aldrich
R4482 T5083 T5079 arg3Of ),(
R4483 T5085 T5084 arg2Of 20 ng/ml,(
R4484 T5086 T5084 arg3Of ),(
R4485 T5088 T5087 arg2Of 30 min,for
R4486 T5090 T5091 arg1Of washed,twice
R4487 T5090 T5092 arg1Of washed,in
R4488 T5095 T5092 arg2Of medium,in
R4489 T5095 T5093 arg1Of medium,complete
R4490 T5095 T5094 arg1Of medium,culture
R4491 T5096 T5046 arg1Of and,For
R4492 T5096 T5048 arg1Of and,","
R4493 T5098 T5096 arg2Of returned,and
R4494 T5098 T5097 arg1Of returned,then
R4495 T5098 T5099 arg1Of returned,to
R4496 T5100 T5099 arg2Of culture,to
R4497 T5103 T5101 arg2Of assays,For
R4498 T5103 T5102 arg1Of assays,luciferase
R4499 T5105 T5106 arg1Of pSV-β-Gal,was
R4500 T5105 T5107 arg2Of pSV-β-Gal,co-transfected
R4501 T5107 T5101 arg1Of co-transfected,For
R4502 T5107 T5104 arg1Of co-transfected,","
R4503 T5107 T5106 arg2Of co-transfected,was
R4504 T5107 T5108 arg1Of co-transfected,with
R4505 T5107 T5110 modOf co-transfected,to
R4506 T5109 T5108 arg2Of pκBluc,with
R4507 T5111 T5110 arg1Of monitor,to
R4508 T5114 T5111 arg2Of efficiency,monitor
R4509 T5114 T5112 arg1Of efficiency,the
R4510 T5114 T5113 arg1Of efficiency,transfection
R4511 T5118 T5115 arg1Of cells,Forty-eight-hour
R4512 T5118 T5116 arg1Of cells,post-transfection
R4513 T5118 T5117 arg1Of cells,","
R4514 T5118 T5119 arg1Of cells,were
R4515 T5118 T5120 arg2Of cells,lysed
R4516 T5120 T5119 arg2Of lysed,were
R4517 T5120 T5121 arg1Of lysed,in
R4518 T5120 T5138 arg1Of lysed,and
R4519 T5123 T5121 arg2Of buffer,in
R4520 T5123 T5122 arg1Of buffer,lysis
R4521 T5123 T5124 arg1Of buffer,of
R4522 T5128 T5124 arg2Of System,of
R4523 T5128 T5125 arg1Of System,Dual
R4524 T5128 T5126 arg1Of System,Light
R4525 T5128 T5127 arg1Of System,Luciferase
R4526 T5128 T5129 arg1Of System,(
R4527 T5130 T5131 arg1Of Tropix,","
R4528 T5131 T5133 arg1Of ",",","
R4529 T5132 T5131 arg2Of Bedford,","
R4530 T5133 T5129 arg2Of ",",(
R4531 T5133 T5135 arg1Of ",",","
R4532 T5134 T5133 arg2Of MA,","
R4533 T5136 T5135 arg2Of USA,","
R4534 T5137 T5129 arg3Of ),(
R4535 T5140 T5141 arg1Of luciferase,and
R4536 T5142 T5141 arg2Of β-galactosidase,and
R4537 T5143 T5139 arg1Of activities,the
R4538 T5143 T5140 arg1Of activities,luciferase
R4539 T5143 T5142 arg1Of activities,β-galactosidase
R4540 T5143 T5144 arg1Of activities,were
R4541 T5143 T5145 arg2Of activities,evaluated
R4542 T5145 T5138 arg2Of evaluated,and
R4543 T5145 T5144 arg2Of evaluated,were
R4544 T5145 T5146 arg1Of evaluated,by
R4545 T5147 T5146 arg2Of using,by
R4546 T5147 T5155 arg1Of using,in
R4547 T5147 T5158 arg1Of using,(
R4548 T5151 T5147 arg2Of System,using
R4549 T5151 T5148 arg1Of System,Dual
R4550 T5151 T5149 arg1Of System,Light
R4551 T5151 T5150 arg1Of System,Luciferase
R4552 T5151 T5152 arg1Of System,(
R4553 T5153 T5152 arg2Of Tropix,(
R4554 T5154 T5152 arg3Of ),(
R4555 T5157 T5155 arg2Of bioluminometer,in
R4556 T5157 T5156 arg1Of bioluminometer,a
R4557 T5160 T5158 arg2Of Biosystem,(
R4558 T5160 T5159 arg1Of Biosystem,Turner
R4559 T5160 T5161 arg1Of Biosystem,","
R4560 T5160 T5165 arg1Of Biosystem,","
R4561 T5160 T5166 arg1Of Biosystem,USA
R4562 T5162 T5161 arg2Of Sunnyvale,","
R4563 T5162 T5163 arg1Of Sunnyvale,","
R4564 T5164 T5163 arg2Of CA,","
R4565 T5167 T5158 arg3Of ),(
R4566 T5169 T5168 arg1Of ratio,The
R4567 T5169 T5170 arg1Of ratio,of
R4568 T5169 T5174 arg1Of ratio,to
R4569 T5169 T5177 arg1Of ratio,was
R4570 T5169 T5178 arg2Of ratio,expressed
R4571 T5173 T5170 arg2Of activity,of
R4572 T5173 T5171 arg1Of activity,firefly
R4573 T5173 T5172 arg1Of activity,luciferase
R4574 T5176 T5174 arg2Of activity,to
R4575 T5176 T5175 arg1Of activity,β-galactosidase
R4576 T5178 T5177 arg2Of expressed,was
R4577 T5178 T5179 arg1Of expressed,as
R4578 T5182 T5179 arg2Of units,as
R4579 T5182 T5180 arg1Of units,relative
R4580 T5182 T5181 arg1Of units,light
R4893 T5683 T5682 arg1Of interference,RNA
R4894 T5684 T5685 arg1Of Jurkat,or
R4895 T5686 T5685 arg2Of U937,or
R4896 T5687 T5684 arg1Of cells,Jurkat
R4897 T5687 T5686 arg1Of cells,U937
R4898 T5687 T5688 arg1Of cells,were
R4899 T5687 T5689 arg2Of cells,transfected
R4900 T5689 T5688 arg2Of transfected,were
R4901 T5691 T5689 arg1Of electroporation,transfected
R4902 T5691 T5690 arg2Of electroporation,by
R4903 T5691 T5692 arg1Of electroporation,using
R4904 T5695 T5692 arg2Of apparatus,using
R4905 T5695 T5693 arg1Of apparatus,a
R4906 T5695 T5694 arg1Of apparatus,Bio-Rad
R4907 T5695 T5696 arg1Of apparatus,(
R4908 T5698 T5697 arg1Of Laboratories,Bio-Rad
R4909 T5698 T5699 arg1Of Laboratories,","
R4910 T5699 T5701 arg1Of ",",","
R4911 T5700 T5699 arg2Of Hercules,","
R4912 T5701 T5696 arg2Of ",",(
R4913 T5701 T5703 arg1Of ",",","
R4914 T5701 T5704 arg1Of ",",USA
R4915 T5702 T5701 arg2Of CA,","
R4916 T5705 T5696 arg3Of ),(
R4917 T5708 T5709 arg1Of aliquots,(
R4918 T5708 T5713 arg1Of aliquots,were
R4919 T5708 T5714 arg2Of aliquots,suspended
R4920 T5708 T5728 arg2Of aliquots,subjected
R4921 T5711 T5709 arg2Of cells,(
R4922 T5711 T5710 arg1Of cells,5 × 106
R4923 T5712 T5709 arg3Of ),(
R4924 T5714 T5715 arg1Of suspended,in
R4925 T5714 T5727 arg1Of suspended,and
R4926 T5716 T5715 arg2Of 0.3 ml,in
R4927 T5716 T5717 arg1Of 0.3 ml,of
R4928 T5716 T5720 arg2Of 0.3 ml,supplemented
R4929 T5718 T5717 arg2Of RPMI,of
R4930 T5718 T5719 arg1Of RPMI,1640
R4931 T5720 T5721 arg1Of supplemented,with
R4932 T5722 T5723 arg1Of 20,%
R4933 T5726 T5721 arg2Of serum,with
R4934 T5726 T5722 arg1Of serum,20
R4935 T5726 T5724 arg1Of serum,fetal
R4936 T5726 T5725 arg1Of serum,calf
R4937 T5727 T5706 arg1Of and,Briefly
R4938 T5727 T5707 arg1Of and,","
R4939 T5727 T5713 arg2Of and,were
R4940 T5727 T5748 arg1Of and,;
R4941 T5728 T5727 arg2Of subjected,and
R4942 T5728 T5729 arg1Of subjected,to
R4943 T5728 T5739 arg1Of subjected,in
R4944 T5733 T5729 arg2Of pulse,to
R4945 T5733 T5730 arg1Of pulse,a
R4946 T5733 T5731 arg1Of pulse,double
R4947 T5733 T5732 arg1Of pulse,electrical
R4948 T5733 T5734 arg1Of pulse,(
R4949 T5735 T5734 arg2Of 0.22 V,(
R4950 T5735 T5736 arg1Of 0.22 V,","
R4951 T5737 T5736 arg2Of 960 µF,","
R4952 T5738 T5734 arg3Of ),(
R4953 T5739 T5740 arg1Of in,the
R4954 T5739 T5742 arg1Of in,of
R4955 T5741 T5739 arg2Of presence,in
R4956 T5744 T5739 arg3Of siRNA,in
R4957 T5744 T5743 arg2Of siRNA,annealed
R4958 T5744 T5745 arg1Of siRNA,(
R4959 T5746 T5745 arg2Of 200 pmol,(
R4960 T5747 T5745 arg3Of ),(
R4961 T5750 T5749 arg2Of cells,electroporated
R4962 T5750 T5751 arg1Of cells,were
R4963 T5750 T5752 arg2Of cells,washed
R4964 T5750 T5754 arg2Of cells,cultured
R4965 T5752 T5753 arg1Of washed,and
R4966 T5753 T5748 arg2Of and,;
R4967 T5753 T5751 arg2Of and,were
R4968 T5753 T5755 arg1Of and,in
R4969 T5754 T5753 arg2Of cultured,and
R4970 T5757 T5755 arg2Of medium,in
R4971 T5757 T5756 arg1Of medium,complete
R4972 T5759 T5758 arg1Of interference,RNA
R4973 T5759 T5760 arg1Of interference,was
R4974 T5759 T5761 arg2Of interference,performed
R4975 T5761 T5760 arg2Of performed,was
R4976 T5761 T5762 arg1Of performed,with
R4977 T5761 T5787 arg1Of performed,UAGCAAUUGUGACAAGCAGUU
R4978 T5762 T5763 arg1Of with,:
R4979 T5766 T5764 arg1Of sense,siRNA
R4980 T5766 T5765 arg1Of sense,Tat
R4981 T5766 T5767 arg1Of sense,","
R4982 T5767 T5769 arg1Of ",",and
R4983 T5768 T5767 arg2Of CUGCUUGUACCAAUUGCUAUU,","
R4984 T5771 T5769 arg2Of Tat,and
R4985 T5771 T5770 arg1Of Tat,siRNA
R4986 T5772 T5773 arg1Of antisense,","
R4987 T5774 T5772 arg1Of UAGCAAUUGGUACAAGCAGUU,antisense
R4988 T5774 T5775 arg1Of UAGCAAUUGGUACAAGCAGUU,;
R4989 T5775 T5779 arg1Of ;,","
R4990 T5778 T5775 arg2Of sense,;
R4991 T5778 T5776 arg1Of sense,siRNA
R4992 T5778 T5777 arg1Of sense,control
R4993 T5779 T5766 arg1Of ",",sense
R4994 T5779 T5768 arg1Of ",",CUGCUUGUACCAAUUGCUAUU
R4995 T5779 T5771 arg1Of ",",Tat
R4996 T5779 T5782 arg1Of ",",and
R4997 T5781 T5779 arg2Of AUUGCUAUU,","
R4998 T5781 T5780 arg1Of AUUGCUAUU,CUGCUUGUCACA
R4999 T5782 T5762 arg2Of and,with
R5000 T5784 T5782 arg2Of control,and
R5001 T5784 T5783 arg1Of control,siRNA
R5002 T5785 T5786 arg1Of antisense,","
R5003 T5787 T5785 arg1Of UAGCAAUUGUGACAAGCAGUU,antisense
R5004 T5789 T5788 arg1Of interference,RNA
R5005 T5789 T5790 arg1Of interference,of
R5006 T5789 T5794 arg1Of interference,was
R5007 T5789 T5795 arg2Of interference,performed
R5008 T5791 T5792 arg1Of p65,and
R5009 T5792 T5790 arg2Of and,of
R5010 T5793 T5792 arg2Of IκB-α,and
R5011 T5795 T5794 arg2Of performed,was
R5012 T5795 T5796 arg1Of performed,with
R5013 T5800 T5797 arg1Of p65,SMART
R5014 T5800 T5798 arg1Of p65,pool
R5015 T5800 T5799 arg1Of p65,siRNA
R5016 T5800 T5801 arg1Of p65,and
R5017 T5801 T5796 arg2Of and,with
R5018 T5802 T5801 arg2Of IκB-α,and
R5019 T5802 T5803 arg1Of IκB-α,(
R5020 T5804 T5805 arg1Of Dharmacon,","
R5021 T5805 T5807 arg1Of ",",","
R5022 T5806 T5805 arg2Of Chicago,","
R5023 T5807 T5803 arg2Of ",",(
R5024 T5807 T5809 arg1Of ",",","
R5025 T5807 T5810 arg1Of ",",USA
R5026 T5808 T5807 arg2Of IL,","
R5027 T5811 T5803 arg3Of ),(
R5180 T6050 T6049 arg2Of virions,Pseudotyped
R5181 T6050 T6051 arg1Of virions,and
R5182 T6054 T6051 arg2Of infection,and
R5183 T6054 T6052 arg1Of infection,single
R5184 T6054 T6053 arg1Of infection,round
R5185 T6056 T6055 arg1Of cells,293T
R5186 T6056 T6057 arg1Of cells,(
R5187 T6056 T6060 arg1Of cells,were
R5188 T6056 T6061 arg2Of cells,transfected
R5189 T6058 T6057 arg2Of 1 × 107,(
R5190 T6059 T6057 arg3Of ),(
R5191 T6061 T6060 arg2Of transfected,were
R5192 T6061 T6062 arg1Of transfected,with
R5193 T6061 T6077 arg1Of transfected,and
R5194 T6063 T6064 arg1Of pNL4-3.Luc.R-E-,or
R5195 T6064 T6062 arg2Of or,with
R5196 T6065 T6064 arg2Of pNL4-3.FLAG-Tat.R-E-,or
R5197 T6065 T6066 arg1Of pNL4-3.FLAG-Tat.R-E-,(
R5198 T6065 T6070 arg1Of pNL4-3.FLAG-Tat.R-E-,with
R5199 T6067 T6066 arg2Of 10 µg,(
R5200 T6068 T6066 arg3Of ),(
R5201 T6070 T6069 arg1Of with,together
R5202 T6072 T6070 arg2Of Env,with
R5203 T6072 T6071 arg1Of Env,pHXB2
R5204 T6072 T6073 arg1Of Env,(
R5205 T6074 T6073 arg2Of 10 µg,(
R5206 T6075 T6073 arg3Of ),(
R5207 T6077 T6076 arg1Of and,","
R5208 T6081 T6078 arg1Of supernatant,48-h
R5209 T6081 T6079 arg1Of supernatant,post-transfection
R5210 T6081 T6080 arg1Of supernatant,cell
R5211 T6081 T6082 arg1Of supernatant,was
R5212 T6081 T6083 arg2Of supernatant,collected
R5213 T6083 T6077 arg2Of collected,and
R5214 T6083 T6082 arg2Of collected,was
R5215 T6086 T6084 arg1Of assay,Enzyme-linked
R5216 T6086 T6085 arg1Of assay,immunosorbent
R5217 T6086 T6087 arg1Of assay,(
R5218 T6086 T6090 arg1Of assay,using
R5219 T6088 T6087 arg2Of ELISA,(
R5220 T6089 T6087 arg3Of ),(
R5221 T6095 T6090 arg2Of concentration,using
R5222 T6095 T6091 arg1Of concentration,anti-p24
R5223 T6095 T6092 arg1Of concentration,antibody
R5224 T6095 T6093 arg2Of concentration,measured
R5225 T6095 T6094 arg1Of concentration,virion
R5226 T6096 T6097 arg1Of PBMCs,","
R5227 T6097 T6099 arg1Of ",",or
R5228 T6098 T6097 arg2Of Jurkat,","
R5229 T6099 T6102 arg1Of or,(
R5230 T6099 T6105 arg1Of or,were
R5231 T6099 T6106 arg2Of or,infected
R5232 T6101 T6099 arg2Of cells,or
R5233 T6101 T6100 arg1Of cells,U937
R5234 T6103 T6102 arg2Of 5 × 107,(
R5235 T6104 T6102 arg3Of ),(
R5236 T6106 T6105 arg2Of infected,were
R5237 T6106 T6107 arg1Of infected,with
R5238 T6110 T6107 arg2Of virions,with
R5239 T6110 T6108 arg1Of virions,HXB2
R5240 T6110 T6109 arg1Of virions,Env-pseudotyped
R5241 T6110 T6111 arg1Of virions,(
R5242 T6110 T6116 arg1Of virions,by
R5243 T6110 T6118 arg1Of virions,","
R5244 T6110 T6119 arg1Of virions,as
R5245 T6112 T6111 arg2Of 500 ng,(
R5246 T6112 T6113 arg1Of 500 ng,of
R5247 T6114 T6113 arg2Of p24,of
R5248 T6115 T6111 arg3Of ),(
R5249 T6117 T6116 arg2Of spinoculation,by
R5250 T6121 T6119 arg2Of described,as
R5251 T6121 T6120 arg1Of described,previously
R5252 T6121 T6122 arg1Of described,(
R5253 T6123 T6122 arg2Of 50,(
R5254 T6124 T6122 arg3Of ),(
R5707 T6719 T6718 arg1Of vitro,In
R5708 T6720 T6719 arg1Of translation,vitro
R5709 T6721 T6722 arg1Of HA-IκB-α,","
R5710 T6722 T6724 arg1Of ",",and
R5711 T6723 T6722 arg2Of p65,","
R5712 T6724 T6726 arg1Of and,were
R5713 T6724 T6727 arg2Of and,expressed
R5714 T6724 T6735 arg2Of and,translated
R5715 T6725 T6724 arg2Of Tat,and
R5716 T6727 T6728 arg1Of expressed,under
R5717 T6727 T6732 arg1Of expressed,and
R5718 T6731 T6728 arg2Of promoter,under
R5719 T6731 T6729 arg1Of promoter,the
R5720 T6731 T6730 arg1Of promoter,T7
R5721 T6732 T6726 arg2Of and,were
R5722 T6734 T6733 arg1Of vitro,in
R5723 T6735 T6732 arg2Of translated,and
R5724 T6735 T6734 arg1Of translated,vitro
R5725 T6735 T6736 modOf translated,using
R5726 T6742 T6736 arg2Of system,using
R5727 T6742 T6737 arg1Of system,the
R5728 T6742 T6738 arg1Of system,TnT
R5729 T6742 T6739 arg1Of system,quick
R5730 T6742 T6740 arg2Of system,coupled
R5731 T6742 T6741 arg1Of system,transcription/translation
R5732 T6742 T6743 arg1Of system,(
R5733 T6742 T6746 arg1Of system,","
R5734 T6742 T6747 arg1Of system,as
R5735 T6744 T6743 arg2Of Promega,(
R5736 T6745 T6743 arg3Of ),(
R5737 T6749 T6747 arg2Of reported,as
R5738 T6749 T6748 arg1Of reported,previously
R5739 T6749 T6750 arg1Of reported,(
R5740 T6751 T6750 arg2Of 50,(
R5741 T6752 T6750 arg3Of ),(
R5742 T6753 T6754 arg1Of Details,are
R5743 T6753 T6755 arg2Of Details,described
R5744 T6755 T6754 arg2Of described,are
R5745 T6755 T6756 arg1Of described,in
R5746 T6758 T6756 arg2Of Data,in
R5747 T6758 T6757 arg1Of Data,Supplementary
R5827 T6883 T6882 arg1Of assay,Immunoprecipitation
R5828 T6883 T6884 arg1Of assay,and
R5829 T6885 T6884 arg2Of GST-pull,and
R5830 T6885 T6886 arg1Of GST-pull,down
R5831 T6887 T6888 arg1Of Immunoprecipitation,","
R5832 T6888 T6890 arg1Of ",",down
R5833 T6888 T6892 arg1Of ",",and
R5834 T6889 T6888 arg2Of GST-pull,","
R5835 T6892 T6891 arg1Of and,","
R5836 T6892 T6894 arg1Of and,of
R5837 T6892 T6897 arg1Of and,in
R5838 T6892 T6902 arg1Of and,were
R5839 T6892 T6903 arg2Of and,performed
R5840 T6893 T6892 arg2Of production,and
R5841 T6896 T6894 arg2Of proteins,of
R5842 T6896 T6895 arg1Of proteins,GST
R5843 T6901 T6897 arg2Of BL21,in
R5844 T6901 T6898 arg1Of BL21,Escherichia
R5845 T6901 T6899 arg1Of BL21,coli
R5846 T6901 T6900 arg1Of BL21,strain
R5847 T6903 T6902 arg2Of performed,were
R5848 T6903 T6904 arg1Of performed,as
R5849 T6906 T6904 arg2Of reported,as
R5850 T6906 T6905 arg1Of reported,previously
R5851 T6906 T6907 arg1Of reported,(
R5899 T7017 T7016 arg1Of PCR,Real-time
R5900 T7019 T7018 arg1Of RNA,Total
R5901 T7019 T7020 arg1Of RNA,was
R5902 T7019 T7021 arg2Of RNA,extracted
R5903 T7019 T7025 arg1Of RNA,using
R5904 T7021 T7020 arg2Of extracted,was
R5905 T7021 T7022 arg1Of extracted,from
R5906 T7021 T7024 arg1Of extracted,by
R5907 T7021 T7032 arg1Of extracted,;
R5908 T7023 T7022 arg2Of cells,from
R5909 T7025 T7024 arg2Of using,by
R5910 T7028 T7025 arg2Of reagent,using
R5911 T7028 T7026 arg1Of reagent,the
R5912 T7028 T7027 arg1Of reagent,TRIzol
R5913 T7028 T7029 arg1Of reagent,(
R5914 T7030 T7029 arg2Of Invitrogen,(
R5915 T7031 T7029 arg3Of ),(
R5916 T7034 T7033 arg1Of aliquots,RNA
R5917 T7034 T7035 arg1Of aliquots,(
R5918 T7034 T7038 arg1Of aliquots,were
R5919 T7036 T7035 arg2Of 200 ng,(
R5920 T7037 T7035 arg3Of ),(
R5921 T7038 T7032 arg2Of were,;
R5922 T7038 T7055 arg1Of were,","
R5923 T7038 T7056 arg1Of were,according
R5924 T7043 T7039 arg1Of Examers,reverse
R5925 T7043 T7040 arg2Of Examers,transcribed
R5926 T7043 T7041 arg1Of Examers,using
R5927 T7043 T7042 arg1Of Examers,Random
R5928 T7043 T7044 arg1Of Examers,(
R5929 T7043 T7047 arg1Of Examers,and
R5930 T7045 T7044 arg2Of Roche,(
R5931 T7046 T7044 arg3Of ),(
R5932 T7047 T7038 arg2Of and,were
R5933 T7051 T7047 arg2Of Transcriptase,and
R5934 T7051 T7048 arg1Of Transcriptase,Superscript
R5935 T7051 T7049 arg1Of Transcriptase,III
R5936 T7051 T7050 arg1Of Transcriptase,Reverse
R5937 T7051 T7052 arg1Of Transcriptase,(
R5938 T7053 T7052 arg2Of Invitrogen,(
R5939 T7054 T7052 arg3Of ),(
R5940 T7057 T7056 arg2Of to,according
R5941 T7059 T7058 arg1Of manufacturer,the
R5942 T7059 T7060 arg2Of manufacturer,'s
R5943 T7061 T7057 arg2Of protocol,to
R5944 T7061 T7060 arg1Of protocol,'s
R5945 T7063 T7062 arg1Of PCR,Real-time
R5946 T7063 T7064 arg1Of PCR,was
R5947 T7063 T7065 arg2Of PCR,performed
R5948 T7063 T7077 arg1Of PCR,carried
R5949 T7065 T7064 arg2Of performed,was
R5950 T7065 T7066 arg1Of performed,with
R5951 T7065 T7076 arg1Of performed,and
R5952 T7070 T7069 arg1Of Super,Green
R5953 T7071 T7066 arg2Of mix,with
R5954 T7071 T7067 arg1Of mix,the
R5955 T7071 T7068 arg1Of mix,iQ
R5956 T7071 T7070 arg1Of mix,Super
R5957 T7071 T7072 arg1Of mix,(
R5958 T7074 T7072 arg2Of Laboratories,(
R5959 T7074 T7073 arg1Of Laboratories,Bio-Rad
R5960 T7075 T7072 arg3Of ),(
R5961 T7076 T7094 arg1Of and,:
R5962 T7077 T7076 arg2Of carried,and
R5963 T7077 T7078 arg1Of carried,out
R5964 T7077 T7079 arg1Of carried,with
R5965 T7085 T7079 arg2Of system,with
R5966 T7085 T7080 arg1Of system,the
R5967 T7085 T7081 arg1Of system,iCycler
R5968 T7085 T7082 arg1Of system,iQ
R5969 T7085 T7083 arg1Of system,Real-Time
R5970 T7085 T7084 arg1Of system,detection
R5971 T7085 T7086 arg1Of system,(
R5972 T7085 T7090 arg1Of system,under
R5973 T7088 T7086 arg2Of Laboratories,(
R5974 T7088 T7087 arg1Of Laboratories,Bio-Rad
R5975 T7089 T7086 arg3Of ),(
R5976 T7093 T7090 arg2Of conditions,under
R5977 T7093 T7091 arg1Of conditions,the
R5978 T7093 T7092 arg1Of conditions,following
R5979 T7095 T7096 arg1Of 95°C,","
R5980 T7095 T7098 arg1Of 95°C,;
R5981 T7097 T7096 arg2Of 1 min,","
R5982 T7100 T7099 arg2Of 94°C,(
R5983 T7100 T7101 arg1Of 94°C,","
R5984 T7100 T7103 arg1Of 94°C,;
R5985 T7102 T7101 arg2Of 10 s,","
R5986 T7104 T7103 arg2Of 60°C,;
R5987 T7104 T7105 arg1Of 60°C,","
R5988 T7106 T7105 arg2Of 30 s,","
R5989 T7107 T7099 arg3Of ),(
R5990 T7108 T7098 arg2Of ×40,;
R5991 T7108 T7099 arg1Of ×40,(
R5992 T7109 T7110 arg1Of Primers,for
R5993 T7109 T7114 arg1Of Primers,are
R5994 T7109 T7115 arg2Of Primers,listed
R5995 T7111 T7112 arg1Of Tat,and
R5996 T7112 T7110 arg2Of and,for
R5997 T7113 T7112 arg2Of MIP-1α,and
R5998 T7115 T7114 arg2Of listed,are
R5999 T7115 T7116 arg1Of listed,in
R6000 T7119 T7117 arg1Of Real-time,Supplementary
R6001 T7119 T7118 arg1Of Real-time,Data.
R6002 T7120 T7116 arg2Of PCR,in
R6003 T7120 T7119 arg1Of PCR,Real-time
R6004 T7120 T7121 arg1Of PCR,of
R6005 T7122 T7121 arg2Of CSF3,of
R6006 T7124 T7125 arg1Of LTA,","
R6007 T7125 T7127 arg1Of ",",","
R6008 T7126 T7125 arg2Of NFKBIA,","
R6009 T7127 T7129 arg1Of ",",","
R6010 T7128 T7127 arg2Of TLR2,","
R6011 T7129 T7131 arg1Of ",",and
R6012 T7130 T7129 arg2Of GAPDH,","
R6013 T7131 T7133 arg1Of and,was
R6014 T7131 T7134 arg2Of and,performed
R6015 T7132 T7131 arg2Of ACTB,and
R6016 T7134 T7114 modOf performed,are
R6017 T7134 T7123 arg1Of performed,","
R6018 T7134 T7133 arg2Of performed,was
R6019 T7135 T7134 arg3Of using,performed
R6020 T7143 T7135 arg2Of pathway,using
R6021 T7143 T7136 arg1Of pathway,the
R6022 T7143 T7137 arg1Of pathway,RT2
R6023 T7143 T7138 arg1Of pathway,profiler
R6024 T7143 T7139 arg1Of pathway,PCR
R6025 T7143 T7140 arg1Of pathway,Array-Human
R6026 T7143 T7141 arg1Of pathway,NF-κB
R6027 T7143 T7142 arg1Of pathway,signaling
R6028 T7143 T7144 arg1Of pathway,(
R6029 T7146 T7144 arg2Of Sciences,(
R6030 T7146 T7145 arg1Of Sciences,QIAGEN
R6031 T7146 T7147 arg1Of Sciences,","
R6032 T7148 T7147 arg2Of MD,","
R6033 T7148 T7149 arg1Of MD,","
R6034 T7150 T7149 arg2Of USA,","
R6035 T7151 T7144 arg3Of ),(
R6036 T7152 T7153 arg1Of Reactions,were
R6037 T7152 T7154 arg2Of Reactions,carried
R6038 T7154 T7153 arg2Of carried,were
R6039 T7154 T7155 arg1Of carried,out
R6040 T7154 T7156 arg1Of carried,in
R6041 T7154 T7159 arg1Of carried,and
R6042 T7157 T7156 arg2Of triplicate,in
R6043 T7159 T7158 arg1Of and,","
R6044 T7162 T7160 arg1Of levels,gene
R6045 T7162 T7161 arg1Of levels,expression
R6046 T7162 T7163 arg1Of levels,were
R6047 T7162 T7164 arg2Of levels,calculated
R6048 T7164 T7159 arg2Of calculated,and
R6049 T7164 T7163 arg2Of calculated,were
R6050 T7164 T7166 arg1Of calculated,to
R6051 T7164 T7170 arg1Of calculated,as
R6052 T7166 T7165 arg1Of to,relative
R6053 T7169 T7166 arg2Of levels,to
R6054 T7169 T7167 arg1Of levels,GAPDH
R6055 T7169 T7168 arg1Of levels,mRNA
R6056 T7172 T7170 arg2Of control,as
R6057 T7172 T7171 arg1Of control,endogenous
R6058 T7174 T7173 arg1Of expression,Relative
R6059 T7174 T7175 arg1Of expression,was
R6060 T7174 T7176 arg2Of expression,calculated
R6061 T7176 T7175 arg2Of calculated,was
R6062 T7176 T7177 arg1Of calculated,as
R6063 T7178 T7177 arg2Of 2,as
R6064 T7178 T7179 arg1Of 2,(
R6065 T7181 T7179 arg2Of gene,(
R6066 T7181 T7180 arg1Of gene,Ct
R6067 T7181 T7182 arg1Of gene,under
R6068 T7184 T7182 arg2Of GAPDH,under
R6069 T7184 T7183 arg1Of GAPDH,investigation − Ct
R6070 T7185 T7179 arg3Of ),(
R6779 T8160 T8159 arg1Of analysis,Statistical
R6780 T8162 T8161 arg1Of analysis,Statistical
R6781 T8162 T8163 arg1Of analysis,was
R6782 T8162 T8164 arg2Of analysis,performed
R6783 T8164 T8163 arg2Of performed,was
R6784 T8168 T8166 arg1Of Student,two-tail
R6785 T8168 T8167 arg1Of Student,unpaired
R6786 T8168 T8169 arg2Of Student,'s
R6787 T8170 T8164 arg1Of t-test,performed
R6788 T8170 T8165 arg2Of t-test,by
R6789 T8170 T8169 arg1Of t-test,'s
R6790 T8171 T8172 arg1Of Data,were
R6791 T8171 T8173 arg2Of Data,reported
R6792 T8173 T8172 arg2Of reported,were
R6793 T8173 T8174 arg1Of reported,as
R6794 T8175 T8174 arg2Of means ± SE,as
R6795 T8176 T8177 arg1Of Differences,between
R6796 T8176 T8180 arg1Of Differences,were
R6797 T8176 T8181 arg2Of Differences,considered
R6798 T8176 T8184 arg1Of Differences,significant
R6799 T8179 T8177 arg2Of means,between
R6800 T8179 T8178 arg1Of means,the
R6801 T8181 T8180 arg2Of considered,were
R6802 T8181 T8190 arg1Of considered,(
R6803 T8184 T8181 arg3Of significant,considered
R6804 T8184 T8182 arg1Of significant,as
R6805 T8184 T8183 arg1Of significant,statistically
R6806 T8184 T8185 arg1Of significant,at
R6807 T8187 T8188 arg1Of 95,%
R6808 T8189 T8185 arg2Of level,at
R6809 T8189 T8186 arg1Of level,the
R6810 T8189 T8187 arg1Of level,95
R6811 T8191 T8190 arg2Of P ,(
R6812 T8191 T8192 arg1Of P ,<
R6813 T8192 T8193 arg1Of <, 0.05
R6814 T8194 T8190 arg3Of ),(
R7042 T8554 T8555 arg1Of Tat,enhances
R7043 T8554 T8560 arg1Of Tat,hijacking
R7044 T8554 T8563 arg1Of Tat,inhibiting
R7045 T8555 T8559 arg1Of enhances,by
R7046 T8558 T8555 arg2Of activity,enhances
R7047 T8558 T8556 arg1Of activity,the
R7048 T8558 T8557 arg1Of activity,NF-κB
R7049 T8560 T8562 arg1Of hijacking,and
R7050 T8561 T8560 arg2Of IκB-α,hijacking
R7051 T8562 T8559 arg2Of and,by
R7052 T8563 T8562 arg2Of inhibiting,and
R7053 T8563 T8567 arg1Of inhibiting,off
R7054 T8566 T8563 arg2Of turn,inhibiting
R7055 T8566 T8564 arg1Of turn,the
R7056 T8566 T8565 arg1Of turn,post-activation
R7057 T8567 T8568 arg1Of off,of
R7058 T8569 T8568 arg2Of NF-κB,of
R7059 T8570 T8571 arg1Of We,analysed
R7060 T8570 T8583 arg1Of We,modulating
R7061 T8571 T8582 arg1Of analysed,by
R7062 T8573 T8571 arg2Of kinetic,analysed
R7063 T8573 T8572 arg1Of kinetic,the
R7064 T8573 T8574 arg1Of kinetic,of
R7065 T8576 T8574 arg2Of activation,of
R7066 T8576 T8575 arg1Of activation,NF-κB
R7067 T8576 T8577 arg1Of activation,in
R7068 T8581 T8577 arg2Of infection,in
R7069 T8581 T8578 arg1Of infection,single
R7070 T8581 T8579 arg1Of infection,round
R7071 T8581 T8580 arg1Of infection,HIV-1
R7072 T8583 T8582 arg2Of modulating,by
R7073 T8585 T8583 arg2Of expression,modulating
R7074 T8585 T8584 arg1Of expression,the
R7075 T8585 T8586 arg1Of expression,of
R7076 T8587 T8586 arg2Of Tat,of
R7077 T8587 T8588 arg1Of Tat,with
R7078 T8590 T8588 arg2Of interference,with
R7079 T8590 T8589 arg1Of interference,RNA
R7080 T8592 T8591 arg1Of cells,Jurkat
R7081 T8592 T8593 arg1Of cells,were
R7082 T8592 T8594 arg2Of cells,transfected
R7083 T8592 T8603 arg1Of cells,left
R7084 T8594 T8593 arg2Of transfected,were
R7085 T8594 T8595 arg1Of transfected,with
R7086 T8594 T8602 arg1Of transfected,or
R7087 T8597 T8596 arg1Of Tat,siRNA
R7088 T8597 T8598 arg1Of Tat,","
R7089 T8598 T8595 arg2Of ",",with
R7090 T8600 T8598 arg2Of control,","
R7091 T8600 T8599 arg1Of control,siRNA
R7092 T8602 T8601 arg1Of or,","
R7093 T8602 T8606 arg1Of or,and
R7094 T8603 T8602 arg2Of left,or
R7095 T8604 T8603 arg2Of untransfected,left
R7096 T8606 T8605 arg1Of and,","
R7097 T8609 T8607 arg1Of cells,24 h
R7098 T8609 T8608 arg1Of cells,later
R7099 T8609 T8610 arg1Of cells,were
R7100 T8609 T8611 arg2Of cells,infected
R7101 T8611 T8606 arg2Of infected,and
R7102 T8611 T8610 arg2Of infected,were
R7103 T8611 T8612 arg1Of infected,with
R7104 T8616 T8612 arg2Of virions,with
R7105 T8616 T8613 arg1Of virions,HXB2
R7106 T8616 T8614 arg1Of virions,Env-pseudotyped
R7107 T8616 T8615 arg1Of virions,NL4-3.Luc.R−E−
R7108 T8619 T8617 arg2Of analysis,By
R7109 T8619 T8618 arg1Of analysis,cytofluorimetric
R7110 T8622 T8621 arg1Of %,∼40
R7111 T8622 T8623 arg1Of %,of
R7112 T8622 T8625 arg1Of %,was
R7113 T8622 T8626 arg1Of %,siRNA-transfected
R7114 T8622 T8628 arg1Of %,HIV-1-infected
R7115 T8624 T8623 arg2Of cells,of
R7116 T8625 T8617 arg1Of was,By
R7117 T8625 T8620 arg1Of was,","
R7118 T8625 T8629 arg1Of was,at
R7119 T8626 T8627 arg1Of siRNA-transfected,and
R7120 T8627 T8625 arg2Of and,was
R7121 T8628 T8627 arg2Of HIV-1-infected,and
R7122 T8631 T8629 arg2Of post-infection,at
R7123 T8631 T8630 arg1Of post-infection,12-h
R7124 T8631 T8632 arg1Of post-infection,(
R7125 T8635 T8632 arg2Of S1,(
R7126 T8635 T8633 arg1Of S1,Supplementary
R7127 T8635 T8634 arg1Of S1,Figure
R7128 T8636 T8632 arg3Of ),(
R7129 T8638 T8637 arg1Of expression,The
R7130 T8638 T8639 arg1Of expression,of
R7131 T8638 T8641 arg1Of expression,was
R7132 T8638 T8642 arg2Of expression,detected
R7133 T8638 T8648 arg1Of expression,increased
R7134 T8638 T8651 arg1Of expression,12 h
R7135 T8640 T8639 arg2Of Tat,of
R7136 T8642 T8641 arg2Of detected,was
R7137 T8642 T8643 arg1Of detected,at
R7138 T8642 T8646 arg1Of detected,and
R7139 T8645 T8643 arg2Of post-infection,at
R7140 T8645 T8644 arg1Of post-infection,1-h
R7141 T8648 T8646 arg2Of increased,and
R7142 T8648 T8647 arg1Of increased,progressively
R7143 T8648 T8649 arg1Of increased,up
R7144 T8648 T8650 modOf increased,to
R7145 T8648 T8658 arg1Of increased,","
R7146 T8648 T8659 arg1Of increased,while
R7147 T8651 T8650 arg1Of 12 h,to
R7148 T8651 T8652 arg1Of 12 h,in
R7149 T8653 T8654 arg1Of untransfected,and
R7150 T8656 T8654 arg2Of control-transfected,and
R7151 T8656 T8655 arg1Of control-transfected,siRNA
R7152 T8657 T8652 arg2Of cells,in
R7153 T8657 T8653 arg1Of cells,untransfected
R7154 T8657 T8656 arg1Of cells,control-transfected
R7155 T8660 T8661 arg1Of it,was
R7156 T8660 T8663 arg2Of it,detected
R7157 T8663 T8659 arg2Of detected,while
R7158 T8663 T8661 arg2Of detected,was
R7159 T8663 T8662 arg1Of detected,barely
R7160 T8663 T8664 arg1Of detected,in
R7161 T8667 T8664 arg2Of cells,in
R7162 T8667 T8665 arg1Of cells,siRNA
R7163 T8667 T8666 arg1Of cells,Tat-transfected
R7164 T8667 T8668 arg1Of cells,(
R7165 T8670 T8668 arg2Of 1A,(
R7166 T8670 T8669 arg1Of 1A,Figure
R7167 T8671 T8668 arg3Of ),(
R7168 T8675 T8672 arg1Of expression,The
R7169 T8675 T8673 arg1Of expression,LTR-dependent
R7170 T8675 T8674 arg1Of expression,luciferase
R7171 T8675 T8676 arg1Of expression,was
R7172 T8675 T8679 arg2Of expression,induced
R7173 T8679 T8676 arg2Of induced,was
R7174 T8679 T8677 arg1Of induced,also
R7175 T8679 T8678 arg1Of induced,progressively
R7176 T8679 T8680 arg1Of induced,at
R7177 T8679 T8685 arg1Of induced,in
R7178 T8679 T8691 arg1Of induced,","
R7179 T8679 T8692 arg1Of induced,while
R7180 T8683 T8681 arg1Of 12-h,1-
R7181 T8683 T8682 arg1Of 12-h,to
R7182 T8684 T8680 arg2Of post-infection,at
R7183 T8684 T8683 arg1Of post-infection,12-h
R7184 T8686 T8687 arg1Of untransfected,and
R7185 T8689 T8687 arg2Of control-transfected,and
R7186 T8689 T8688 arg1Of control-transfected,siRNA
R7187 T8690 T8685 arg2Of cells,in
R7188 T8690 T8686 arg1Of cells,untransfected
R7189 T8690 T8689 arg1Of cells,control-transfected
R7190 T8693 T8694 arg1Of it,was
R7191 T8693 T8696 arg2Of it,observed
R7192 T8696 T8692 arg2Of observed,while
R7193 T8696 T8694 arg2Of observed,was
R7194 T8696 T8695 arg1Of observed,barely
R7195 T8696 T8697 arg1Of observed,in
R7196 T8696 T8701 arg1Of observed,","
R7197 T8700 T8697 arg2Of cells,in
R7198 T8700 T8698 arg1Of cells,siRNA
R7199 T8700 T8699 arg1Of cells,Tat-transfected
R7200 T8702 T8696 arg3Of as,observed
R7201 T8703 T8702 arg2Of expected,as
R7202 T8703 T8704 arg1Of expected,for
R7203 T8707 T8704 arg2Of transactivation,for
R7204 T8707 T8705 arg1Of transactivation,the
R7205 T8707 T8706 arg1Of transactivation,Tat-dependent
R7206 T8707 T8708 arg1Of transactivation,of
R7207 T8711 T8708 arg2Of LTR,of
R7208 T8711 T8709 arg1Of LTR,the
R7209 T8711 T8710 arg1Of LTR,HIV-1
R7210 T8711 T8712 arg1Of LTR,(
R7211 T8714 T8712 arg2Of 1A,(
R7212 T8714 T8713 arg1Of 1A,Figure
R7213 T8715 T8712 arg3Of ),(
R7214 T8718 T8716 arg1Of increase,The
R7215 T8718 T8717 arg1Of increase,progressive
R7216 T8718 T8719 arg1Of increase,in
R7217 T8718 T8747 arg1Of increase,was
R7218 T8718 T8748 arg2Of increase,observed
R7219 T8721 T8719 arg2Of activity,in
R7220 T8721 T8720 arg1Of activity,NF-κB
R7221 T8724 T8723 arg2Of measured,as
R7222 T8727 T8724 arg1Of binding,measured
R7223 T8727 T8725 arg2Of binding,by
R7224 T8727 T8726 arg1Of binding,p65–p50
R7225 T8727 T8728 arg1Of binding,to
R7226 T8732 T8729 arg1Of oligonucleotide,an
R7227 T8732 T8730 arg1Of oligonucleotide,NF-κB
R7228 T8732 T8731 arg1Of oligonucleotide,consensus
R7229 T8732 T8733 arg1Of oligonucleotide,(
R7230 T8732 T8737 arg1Of oligonucleotide,and
R7231 T8735 T8733 arg2Of 1B,(
R7232 T8735 T8734 arg1Of 1B,Figure
R7233 T8736 T8733 arg3Of ),(
R7234 T8737 T8728 arg2Of and,to
R7235 T8739 T8737 arg2Of p65,and
R7236 T8739 T8738 arg1Of p65,nuclear
R7237 T8739 T8740 arg1Of p65,(
R7238 T8742 T8740 arg2Of 1C,(
R7239 T8742 T8741 arg1Of 1C,Figure
R7240 T8742 T8743 arg1Of 1C,","
R7241 T8744 T8743 arg2Of nucleus,","
R7242 T8745 T8740 arg3Of ),(
R7243 T8748 T8722 arg1Of observed,","
R7244 T8748 T8723 arg1Of observed,as
R7245 T8748 T8746 arg1Of observed,","
R7246 T8748 T8747 arg2Of observed,was
R7247 T8748 T8749 arg1Of observed,at
R7248 T8748 T8754 arg1Of observed,in
R7249 T8748 T8771 arg1Of observed,;
R7250 T8752 T8750 arg1Of 3-h,1-
R7251 T8752 T8751 arg1Of 3-h,to
R7252 T8753 T8749 arg2Of post-infection,at
R7253 T8753 T8752 arg1Of post-infection,3-h
R7254 T8756 T8755 arg1Of Tat-positive,both
R7255 T8756 T8757 arg1Of Tat-positive,(
R7256 T8756 T8764 arg1Of Tat-positive,and
R7257 T8759 T8760 arg1Of siRNA,or
R7258 T8760 T8757 arg2Of or,(
R7259 T8760 T8758 arg1Of or,no
R7260 T8762 T8760 arg2Of control,or
R7261 T8762 T8761 arg1Of control,siRNA
R7262 T8763 T8757 arg3Of ),(
R7263 T8764 T8754 arg2Of and,in
R7264 T8768 T8766 arg2Of Tat,(
R7265 T8768 T8767 arg1Of Tat,siRNA
R7266 T8769 T8766 arg3Of ),(
R7267 T8770 T8764 arg2Of cells,and
R7268 T8770 T8765 arg1Of cells,Tat-negative
R7269 T8770 T8766 arg1Of cells,(
R7270 T8771 T8772 arg1Of ;,however
R7271 T8771 T8773 arg1Of ;,","
R7272 T8776 T8774 arg2Of post-infection,at
R7273 T8776 T8775 arg1Of post-infection,12-h
R7274 T8781 T8779 arg1Of binding,p65
R7275 T8781 T8780 arg1Of binding,DNA
R7276 T8781 T8782 arg1Of binding,and
R7277 T8782 T8778 arg1Of and,the
R7278 T8782 T8785 arg1Of and,persisted
R7279 T8782 T8786 arg2Of and,elevated
R7280 T8784 T8782 arg2Of p65,and
R7281 T8784 T8783 arg1Of p65,nuclear
R7282 T8785 T8771 arg2Of persisted,;
R7283 T8785 T8774 arg1Of persisted,at
R7284 T8785 T8777 arg1Of persisted,","
R7285 T8785 T8786 modOf persisted,elevated
R7286 T8785 T8798 arg1Of persisted,","
R7287 T8785 T8799 arg1Of persisted,while
R7288 T8786 T8787 arg1Of elevated,in
R7289 T8787 T8789 arg1Of in,of
R7290 T8788 T8787 arg2Of presence,in
R7291 T8790 T8787 arg3Of Tat,in
R7292 T8790 T8791 arg1Of Tat,(
R7293 T8793 T8794 arg1Of siRNA,and
R7294 T8794 T8791 arg2Of and,(
R7295 T8794 T8792 arg1Of and,no
R7296 T8796 T8794 arg2Of control,and
R7297 T8796 T8795 arg1Of control,siRNA
R7298 T8797 T8791 arg3Of ),(
R7299 T8800 T8801 arg1Of they,dropped
R7300 T8801 T8799 arg2Of dropped,while
R7301 T8801 T8802 arg1Of dropped,in
R7302 T8802 T8804 arg1Of in,of
R7303 T8803 T8802 arg2Of absence,in
R7304 T8805 T8802 arg3Of Tat,in
R7305 T8805 T8806 arg1Of Tat,(
R7306 T8805 T8810 arg1Of Tat,(
R7307 T8808 T8806 arg2Of Tat,(
R7308 T8808 T8807 arg1Of Tat,siRNA
R7309 T8809 T8806 arg3Of ),(
R7310 T8812 T8811 arg1Of 1B,Figure
R7311 T8812 T8813 arg1Of 1B,and
R7312 T8813 T8810 arg2Of and,(
R7313 T8814 T8813 arg2Of C,and
R7314 T8815 T8810 arg3Of ),(
R7315 T8816 T8817 arg1Of IκB-α,was
R7316 T8816 T8818 arg2Of IκB-α,degraded
R7317 T8816 T8828 arg2Of IκB-α,synthesized
R7318 T8818 T8817 arg2Of degraded,was
R7319 T8818 T8819 arg1Of degraded,in
R7320 T8818 T8827 arg1Of degraded,novo
R7321 T8818 T8828 modOf degraded,synthesized
R7322 T8821 T8819 arg2Of cytosol,in
R7323 T8821 T8820 arg1Of cytosol,the
R7324 T8821 T8822 arg1Of cytosol,within
R7325 T8824 T8822 arg2Of post-infection,within
R7326 T8824 T8823 arg1Of post-infection,3-h
R7327 T8827 T8825 arg1Of novo,and
R7328 T8827 T8826 arg1Of novo,de
R7329 T8828 T8829 arg1Of synthesized,at
R7330 T8828 T8834 arg1Of synthesized,at
R7331 T8830 T8829 arg2Of 6 h,at
R7332 T8830 T8831 arg1Of 6 h,with
R7333 T8833 T8831 arg2Of replenishment,with
R7334 T8833 T8832 arg1Of replenishment,full
R7335 T8836 T8834 arg2Of post-infection,at
R7336 T8836 T8835 arg1Of post-infection,12-h
R7337 T8836 T8837 arg1Of post-infection,in
R7338 T8839 T8840 arg1Of Tat-positive,and
R7339 T8841 T8840 arg2Of Tat-negative,and
R7340 T8842 T8837 arg2Of cells,in
R7341 T8842 T8838 arg1Of cells,both
R7342 T8842 T8839 arg1Of cells,Tat-positive
R7343 T8842 T8841 arg1Of cells,Tat-negative
R7344 T8842 T8843 arg1Of cells,(
R7345 T8845 T8843 arg2Of 1C,(
R7346 T8845 T8844 arg1Of 1C,Figure
R7347 T8845 T8846 arg1Of 1C,","
R7348 T8847 T8846 arg2Of cytosol,","
R7349 T8848 T8843 arg3Of ),(
R7350 T8853 T8851 arg1Of activity,the
R7351 T8853 T8852 arg1Of activity,IKK
R7352 T8853 T8854 arg1Of activity,was
R7353 T8853 T8855 arg2Of activity,induced
R7354 T8853 T8861 arg1Of activity,decreased
R7355 T8855 T8854 arg2Of induced,was
R7356 T8855 T8856 arg1Of induced,at
R7357 T8855 T8860 arg1Of induced,and
R7358 T8858 T8856 arg2Of post-infection,at
R7359 T8858 T8857 arg1Of post-infection,1-h
R7360 T8860 T8849 arg1Of and,Consistently
R7361 T8860 T8850 arg1Of and,","
R7362 T8860 T8859 arg1Of and,","
R7363 T8861 T8860 arg2Of decreased,and
R7364 T8861 T8862 arg1Of decreased,at
R7365 T8862 T8864 arg1Of at,post-infection
R7366 T8863 T8862 arg2Of 3-h,at
R7367 T8864 T8865 arg1Of post-infection,independently
R7368 T8865 T8866 arg1Of independently,of
R7369 T8868 T8866 arg2Of presence,of
R7370 T8868 T8867 arg1Of presence,the
R7371 T8868 T8869 arg1Of presence,of
R7372 T8870 T8869 arg2Of Tat,of
R7373 T8870 T8871 arg1Of Tat,(
R7374 T8873 T8871 arg2Of 1D,(
R7375 T8873 T8872 arg1Of 1D,Figure
R7376 T8874 T8871 arg3Of ),(
R7377 T8876 T8875 arg1Of kinetics,Similar
R7378 T8876 T8877 arg1Of kinetics,of
R7379 T8876 T8886 arg1Of kinetics,were
R7380 T8876 T8887 arg2Of kinetics,observed
R7381 T8879 T8878 arg1Of activity,NF-κB
R7382 T8879 T8880 arg1Of activity,","
R7383 T8880 T8883 arg1Of ",",and
R7384 T8882 T8880 arg2Of activation,","
R7385 T8882 T8881 arg1Of activation,IKK
R7386 T8883 T8877 arg2Of and,of
R7387 T8885 T8883 arg2Of degradation/re-synthesis,and
R7388 T8885 T8884 arg1Of degradation/re-synthesis,IκB-α
R7389 T8887 T8886 arg2Of observed,were
R7390 T8887 T8888 arg1Of observed,in
R7391 T8891 T8888 arg2Of infection,in
R7392 T8891 T8889 arg1Of infection,single-round
R7393 T8891 T8890 arg1Of infection,HIV-1
R7394 T8891 T8892 arg1Of infection,of
R7395 T8893 T8892 arg2Of PBMCs,of
R7396 T8893 T8894 arg1Of PBMCs,using
R7397 T8894 T8907 arg1Of using,as
R7398 T8896 T8894 arg2Of cocktail,using
R7399 T8896 T8895 arg1Of cocktail,a
R7400 T8896 T8897 arg1Of cocktail,of
R7401 T8898 T8899 arg1Of Azidothymidine,(
R7402 T8898 T8902 arg1Of Azidothymidine,and
R7403 T8900 T8899 arg2Of AZT,(
R7404 T8901 T8899 arg3Of ),(
R7405 T8902 T8897 arg2Of and,of
R7406 T8903 T8902 arg2Of Lamivudine,and
R7407 T8903 T8904 arg1Of Lamivudine,(
R7408 T8905 T8904 arg2Of 3TC,(
R7409 T8906 T8904 arg3Of ),(
R7410 T8910 T8907 arg2Of inhibitors,as
R7411 T8910 T8908 arg1Of inhibitors,reverse
R7412 T8910 T8909 arg1Of inhibitors,transcriptase
R7413 T8910 T8911 arg1Of inhibitors,(
R7414 T8914 T8911 arg2Of S2,(
R7415 T8914 T8912 arg1Of S2,Supplementary
R7416 T8914 T8913 arg1Of S2,Figure
R7417 T8915 T8911 arg3Of ),(
R7418 T8917 T8916 arg1Of results,These
R7419 T8917 T8918 arg1Of results,indicated
R7420 T8923 T8920 arg2Of infection,in
R7421 T8923 T8921 arg1Of infection,single-round
R7422 T8923 T8922 arg1Of infection,HIV-1
R7423 T8926 T8924 arg1Of activation,the
R7424 T8926 T8925 arg1Of activation,NF-κB
R7425 T8926 T8928 arg1Of activation,correlated
R7426 T8928 T8927 arg1Of correlated,initially
R7427 T8928 T8929 arg1Of correlated,with
R7428 T8928 T8936 arg1Of correlated,independently
R7429 T8928 T8943 arg1Of correlated,and
R7430 T8932 T8931 arg1Of activation,IKK
R7431 T8932 T8933 arg1Of activation,and
R7432 T8933 T8929 arg2Of and,with
R7433 T8933 T8930 arg1Of and,the
R7434 T8935 T8933 arg2Of degradation,and
R7435 T8935 T8934 arg1Of degradation,IκB-α
R7436 T8936 T8937 arg1Of independently,of
R7437 T8939 T8937 arg2Of presence,of
R7438 T8939 T8938 arg1Of presence,the
R7439 T8939 T8940 arg1Of presence,of
R7440 T8941 T8940 arg2Of Tat,of
R7441 T8943 T8918 arg2Of and,indicated
R7442 T8943 T8919 arg1Of and,that
R7443 T8943 T8920 arg1Of and,in
R7444 T8943 T8942 arg1Of and,","
R7445 T8944 T8945 arg1Of it,was
R7446 T8944 T8946 arg2Of it,kept
R7447 T8944 T8947 arg2Of it,elevated
R7448 T8946 T8943 arg2Of kept,and
R7449 T8946 T8945 arg2Of kept,was
R7450 T8947 T8946 arg3Of elevated,kept
R7451 T8947 T8948 arg1Of elevated,in
R7452 T8949 T8950 arg1Of presence,of
R7453 T8949 T8952 arg1Of presence,following
R7454 T8949 T8959 arg1Of presence,and
R7455 T8951 T8950 arg2Of Tat,of
R7456 T8954 T8952 arg2Of decay,following
R7457 T8954 T8953 arg1Of decay,the
R7458 T8954 T8955 arg1Of decay,of
R7459 T8958 T8955 arg2Of activity,of
R7460 T8958 T8956 arg1Of activity,the
R7461 T8958 T8957 arg1Of activity,IKK
R7462 T8959 T8948 arg2Of and,in
R7463 T8961 T8959 arg2Of synthesis,and
R7464 T8961 T8960 arg1Of synthesis,new
R7465 T8961 T8962 arg1Of synthesis,of
R7466 T8963 T8962 arg2Of IκB-α,of
R7467 T8966 T8967 arg1Of we,tested
R7468 T8967 T8964 arg1Of tested,Next
R7469 T8967 T8965 arg1Of tested,","
R7470 T8970 T8967 arg2Of action,tested
R7471 T8970 T8968 arg1Of action,the
R7472 T8970 T8969 arg1Of action,single
R7473 T8970 T8971 arg1Of action,of
R7474 T8970 T8973 arg1Of action,on
R7475 T8972 T8971 arg2Of Tat,of
R7476 T8975 T8973 arg2Of kinetic,on
R7477 T8975 T8974 arg1Of kinetic,the
R7478 T8975 T8976 arg1Of kinetic,of
R7479 T8978 T8976 arg2Of activity,of
R7480 T8978 T8977 arg1Of activity,NF-κB
R7481 T8978 T8979 arg2Of activity,induced
R7482 T8981 T8979 arg1Of PMA,induced
R7483 T8981 T8980 arg2Of PMA,by
R7484 T8984 T8982 arg2Of end,To
R7485 T8984 T8983 arg1Of end,this
R7486 T8987 T8986 arg1Of cells,HeLa
R7487 T8987 T8988 arg1Of cells,were
R7488 T8987 T8989 arg2Of cells,transfected
R7489 T8989 T8982 arg1Of transfected,To
R7490 T8989 T8985 arg1Of transfected,","
R7491 T8989 T8988 arg2Of transfected,were
R7492 T8989 T8990 arg1Of transfected,with
R7493 T8991 T8993 arg1Of p3x-FLAG-Tat,or
R7494 T8993 T8990 arg2Of or,with
R7495 T8993 T8992 arg1Of or,","
R7496 T8993 T8996 arg1Of or,","
R7497 T8993 T8997 arg2Of or,stimulated
R7498 T8993 T9005 arg2Of or,washed
R7499 T8993 T9007 arg1Of or,avoid
R7500 T8995 T8993 arg2Of vector,or
R7501 T8995 T8994 arg1Of vector,empty
R7502 T8997 T8998 arg1Of stimulated,with
R7503 T8997 T9003 arg1Of stimulated,and
R7504 T8999 T8998 arg2Of PMA,with
R7505 T8999 T9000 arg1Of PMA,for
R7506 T9001 T9000 arg2Of 5 min,for
R7507 T9003 T9002 arg1Of and,","
R7508 T9005 T9003 arg2Of washed,and
R7509 T9005 T9004 arg1Of washed,extensively
R7510 T9007 T9005 arg3Of avoid,washed
R7511 T9007 T9006 arg1Of avoid,to
R7512 T9010 T9007 arg2Of kinetic,avoid
R7513 T9010 T9008 arg1Of kinetic,the
R7514 T9010 T9009 arg1Of kinetic,oscillatory
R7515 T9010 T9011 arg1Of kinetic,of
R7516 T9013 T9011 arg2Of activation,of
R7517 T9013 T9012 arg1Of activation,NF-κB
R7518 T9013 T9014 arg1Of activation,(
R7519 T9015 T9014 arg2Of "17,18",(
R7520 T9016 T9014 arg3Of ),(
R7521 T9019 T9017 arg2Of cells,In
R7522 T9019 T9018 arg1Of cells,un-stimulated
R7523 T9024 T9021 arg1Of binding,the
R7524 T9024 T9022 arg1Of binding,p65
R7525 T9024 T9023 arg1Of binding,DNA
R7526 T9024 T9025 arg1Of binding,(
R7527 T9024 T9029 arg1Of binding,and
R7528 T9027 T9025 arg2Of 2A,(
R7529 T9027 T9026 arg1Of 2A,Figure
R7530 T9028 T9025 arg3Of ),(
R7531 T9029 T9038 arg1Of and,were
R7532 T9029 T9040 arg2Of and,enhanced
R7533 T9031 T9029 arg2Of p65,and
R7534 T9031 T9030 arg1Of p65,nuclear
R7535 T9031 T9032 arg1Of p65,(
R7536 T9034 T9032 arg2Of 2B,(
R7537 T9034 T9033 arg1Of 2B,Figure
R7538 T9034 T9035 arg1Of 2B,","
R7539 T9036 T9035 arg2Of nucleus,","
R7540 T9037 T9032 arg3Of ),(
R7541 T9040 T9017 arg1Of enhanced,In
R7542 T9040 T9020 arg1Of enhanced,","
R7543 T9040 T9038 arg2Of enhanced,were
R7544 T9040 T9039 arg1Of enhanced,slightly
R7545 T9040 T9043 arg1Of enhanced,","
R7546 T9040 T9044 arg1Of enhanced,while
R7547 T9040 T9052 arg1Of enhanced,(
R7548 T9042 T9040 arg1Of Tat,enhanced
R7549 T9042 T9041 arg2Of Tat,by
R7550 T9047 T9045 arg1Of content,the
R7551 T9047 T9046 arg1Of content,IκB-α
R7552 T9047 T9048 arg1Of content,was
R7553 T9047 T9051 arg2Of content,affected
R7554 T9051 T9044 arg2Of affected,while
R7555 T9051 T9048 arg2Of affected,was
R7556 T9051 T9049 arg1Of affected,not
R7557 T9051 T9050 arg1Of affected,significantly
R7558 T9054 T9052 arg2Of 2B,(
R7559 T9054 T9053 arg1Of 2B,Figure
R7560 T9054 T9055 arg1Of 2B,","
R7561 T9056 T9055 arg2Of cytosol,","
R7562 T9057 T9052 arg3Of ),(
R7563 T9059 T9058 arg1Of stimulation,Transient
R7564 T9059 T9060 arg1Of stimulation,with
R7565 T9059 T9062 arg1Of stimulation,increased
R7566 T9061 T9060 arg2Of PMA,with
R7567 T9062 T9076 arg1Of increased,independently
R7568 T9062 T9088 arg1Of increased,;
R7569 T9067 T9064 arg1Of activity,NF-κB
R7570 T9067 T9065 arg1Of activity,DNA
R7571 T9067 T9066 arg1Of activity,binding
R7572 T9067 T9068 arg1Of activity,and
R7573 T9068 T9062 arg2Of and,increased
R7574 T9068 T9063 arg1Of and,the
R7575 T9068 T9071 arg1Of and,at
R7576 T9070 T9068 arg2Of p65,and
R7577 T9070 T9069 arg1Of p65,nuclear
R7578 T9072 T9071 arg2Of 5 min,at
R7579 T9072 T9073 arg1Of 5 min,peaking
R7580 T9073 T9074 arg1Of peaking,at
R7581 T9075 T9074 arg2Of 60–120 min,at
R7582 T9076 T9077 arg1Of independently,of
R7583 T9079 T9077 arg2Of presence,of
R7584 T9079 T9078 arg1Of presence,the
R7585 T9079 T9080 arg1Of presence,of
R7586 T9081 T9080 arg2Of Tat,of
R7587 T9081 T9082 arg1Of Tat,(
R7588 T9084 T9083 arg1Of 2A,Figure
R7589 T9084 T9085 arg1Of 2A,and
R7590 T9085 T9082 arg2Of and,(
R7591 T9086 T9085 arg2Of B,and
R7592 T9087 T9082 arg3Of ),(
R7593 T9095 T9093 arg1Of binding,p65
R7594 T9095 T9094 arg1Of binding,DNA
R7595 T9095 T9096 arg1Of binding,and
R7596 T9096 T9092 arg1Of and,the
R7597 T9096 T9099 arg1Of and,persisted
R7598 T9096 T9100 arg2Of and,elevated
R7599 T9098 T9096 arg2Of p65,and
R7600 T9098 T9097 arg1Of p65,nuclear
R7601 T9099 T9091 arg2Of persisted,while
R7602 T9099 T9100 modOf persisted,elevated
R7603 T9099 T9101 arg1Of persisted,at
R7604 T9099 T9104 arg1Of persisted,in
R7605 T9103 T9101 arg2Of post-treatment,at
R7606 T9103 T9102 arg1Of post-treatment,240-min
R7607 T9106 T9104 arg2Of cells,in
R7608 T9106 T9105 arg1Of cells,Tat-positive
R7609 T9108 T9109 arg1Of they,dropped
R7610 T9109 T9088 arg2Of dropped,;
R7611 T9109 T9089 arg1Of dropped,however
R7612 T9109 T9090 arg1Of dropped,","
R7613 T9109 T9091 arg1Of dropped,while
R7614 T9109 T9107 arg1Of dropped,","
R7615 T9109 T9110 arg1Of dropped,in
R7616 T9112 T9110 arg2Of cells,in
R7617 T9112 T9111 arg1Of cells,Tat-negative
R7618 T9112 T9113 arg1Of cells,(
R7619 T9115 T9114 arg1Of 2A,Figure
R7620 T9115 T9116 arg1Of 2A,and
R7621 T9116 T9113 arg2Of and,(
R7622 T9117 T9116 arg2Of B,and
R7623 T9118 T9113 arg3Of ),(
R7624 T9120 T9119 arg2Of addition,In
R7625 T9122 T9123 arg1Of Tat,bound
R7626 T9123 T9124 arg1Of bound,to
R7627 T9123 T9131 arg1Of bound,and
R7628 T9127 T9124 arg2Of oligonucleotide,to
R7629 T9127 T9125 arg1Of oligonucleotide,the
R7630 T9127 T9126 arg1Of oligonucleotide,NF-κB
R7631 T9127 T9128 arg1Of oligonucleotide,in
R7632 T9130 T9128 arg2Of cells,in
R7633 T9130 T9129 arg1Of cells,un-stimulated
R7634 T9131 T9119 arg1Of and,In
R7635 T9131 T9121 arg1Of and,","
R7636 T9133 T9132 arg1Of binding,its
R7637 T9133 T9134 arg1Of binding,increased
R7638 T9134 T9131 arg2Of increased,and
R7639 T9134 T9135 arg1Of increased,following
R7640 T9134 T9142 arg1Of increased,","
R7641 T9137 T9135 arg2Of stimulation,following
R7642 T9137 T9136 arg1Of stimulation,PMA
R7643 T9137 T9138 arg1Of stimulation,(
R7644 T9140 T9138 arg2Of 2A,(
R7645 T9140 T9139 arg1Of 2A,Figure
R7646 T9141 T9138 arg3Of ),(
R7647 T9143 T9134 arg2Of suggesting,increased
R7648 T9143 T9156 arg1Of suggesting,to
R7649 T9147 T9145 arg1Of protein,the
R7650 T9147 T9146 arg1Of protein,viral
R7651 T9147 T9148 arg1Of protein,was
R7652 T9148 T9143 arg2Of was,suggesting
R7653 T9148 T9144 arg1Of was,that
R7654 T9150 T9148 arg2Of component,was
R7655 T9150 T9149 arg1Of component,a
R7656 T9150 T9151 arg1Of component,of
R7657 T9154 T9151 arg2Of complex,of
R7658 T9154 T9152 arg1Of complex,the
R7659 T9154 T9153 arg1Of complex,NF-κB
R7660 T9154 T9155 arg2Of complex,bound
R7661 T9157 T9156 arg2Of DNA,to
R7662 T9158 T9159 arg1Of Degradation,of
R7663 T9158 T9161 arg1Of Degradation,was
R7664 T9158 T9163 arg2Of Degradation,induced
R7665 T9160 T9159 arg2Of IκB-α,of
R7666 T9163 T9161 arg2Of induced,was
R7667 T9163 T9162 arg1Of induced,progressively
R7668 T9163 T9164 arg1Of induced,at
R7669 T9163 T9166 arg1Of induced,","
R7670 T9163 T9167 modOf induced,followed
R7671 T9165 T9164 arg2Of 5–30 min,at
R7672 T9170 T9169 arg1Of novo,de
R7673 T9171 T9167 arg1Of synthesis,followed
R7674 T9171 T9168 arg2Of synthesis,by
R7675 T9171 T9170 arg1Of synthesis,novo
R7676 T9171 T9172 arg1Of synthesis,at
R7677 T9173 T9172 arg2Of 60 min,at
R7678 T9173 T9174 arg1Of 60 min,with
R7679 T9176 T9174 arg2Of replenishment,with
R7680 T9176 T9175 arg1Of replenishment,full
R7681 T9176 T9177 arg1Of replenishment,at
R7682 T9178 T9177 arg2Of 240 min,at
R7683 T9178 T9179 arg1Of 240 min,in
R7684 T9181 T9182 arg1Of Tat-positive,and
R7685 T9183 T9182 arg2Of negative,and
R7686 T9184 T9179 arg2Of cells,in
R7687 T9184 T9180 arg1Of cells,both
R7688 T9184 T9181 arg1Of cells,Tat-positive
R7689 T9184 T9183 arg1Of cells,negative
R7690 T9184 T9185 arg1Of cells,(
R7691 T9187 T9185 arg2Of 2B,(
R7692 T9187 T9186 arg1Of 2B,Figure
R7693 T9187 T9188 arg1Of 2B,","
R7694 T9189 T9188 arg2Of cytosol,","
R7695 T9190 T9185 arg3Of ),(
R7696 T9195 T9193 arg1Of activation,the
R7697 T9195 T9194 arg1Of activation,IKK
R7698 T9195 T9196 arg1Of activation,started
R7699 T9195 T9201 arg1Of activation,turned
R7700 T9196 T9197 arg1Of started,at
R7701 T9196 T9200 arg1Of started,and
R7702 T9198 T9197 arg2Of 5 min,at
R7703 T9200 T9191 arg1Of and,Consistently
R7704 T9200 T9192 arg1Of and,","
R7705 T9200 T9199 arg1Of and,","
R7706 T9201 T9200 arg2Of turned,and
R7707 T9201 T9202 arg1Of turned,off
R7708 T9201 T9203 arg1Of turned,at
R7709 T9201 T9205 arg1Of turned,independently
R7710 T9204 T9203 arg2Of 30 min,at
R7711 T9205 T9206 arg1Of independently,of
R7712 T9208 T9206 arg2Of presence,of
R7713 T9208 T9207 arg1Of presence,the
R7714 T9208 T9209 arg1Of presence,of
R7715 T9210 T9209 arg2Of Tat,of
R7716 T9210 T9211 arg1Of Tat,(
R7717 T9213 T9211 arg2Of 2C,(
R7718 T9213 T9212 arg1Of 2C,Figure
R7719 T9214 T9211 arg3Of ),(
R7720 T9216 T9215 arg1Of results,These
R7721 T9216 T9217 arg1Of results,indicated
R7722 T9219 T9220 arg1Of Tat,enhanced
R7723 T9219 T9230 arg1Of Tat,affecting
R7724 T9220 T9217 arg2Of enhanced,indicated
R7725 T9220 T9218 arg1Of enhanced,that
R7726 T9220 T9224 arg1Of enhanced,in
R7727 T9220 T9229 arg1Of enhanced,without
R7728 T9223 T9220 arg2Of activity,enhanced
R7729 T9223 T9221 arg1Of activity,the
R7730 T9223 T9222 arg1Of activity,NF-κB
R7731 T9225 T9226 arg1Of un-stimulated,and
R7732 T9227 T9226 arg2Of PMA-stimulated,and
R7733 T9228 T9224 arg2Of cells,in
R7734 T9228 T9225 arg1Of cells,un-stimulated
R7735 T9228 T9227 arg1Of cells,PMA-stimulated
R7736 T9230 T9229 arg2Of affecting,without
R7737 T9233 T9232 arg1Of activity,IKK
R7738 T9233 T9234 arg1Of activity,and
R7739 T9234 T9230 arg2Of and,affecting
R7740 T9234 T9231 arg1Of and,the
R7741 T9236 T9234 arg2Of content,and
R7742 T9236 T9235 arg1Of content,IκB-α
R7743 T9238 T9240 arg1Of we,found
R7744 T9240 T9237 arg2Of found,As
R7745 T9240 T9239 arg1Of found,previously
R7746 T9242 T9243 arg1Of Tat,binds
R7747 T9243 T9240 arg2Of binds,found
R7748 T9243 T9241 arg1Of binds,that
R7749 T9243 T9244 arg1Of binds,to
R7750 T9247 T9244 arg2Of ankyrin,to
R7751 T9247 T9245 arg1Of ankyrin,the
R7752 T9247 T9246 arg1Of ankyrin,sixth
R7753 T9247 T9248 arg1Of ankyrin,of
R7754 T9249 T9248 arg2Of IκB-α,of
R7755 T9249 T9250 arg1Of IκB-α,(
R7756 T9251 T9250 arg2Of "50,51",(
R7757 T9252 T9250 arg3Of ),(
R7758 T9254 T9255 arg1Of we,tested
R7759 T9255 T9237 arg1Of tested,As
R7760 T9255 T9253 arg1Of tested,","
R7761 T9257 T9258 arg1Of Tat,counteracted
R7762 T9258 T9255 arg2Of counteracted,tested
R7763 T9258 T9256 arg1Of counteracted,whether
R7764 T9260 T9258 arg2Of generation,counteracted
R7765 T9260 T9259 arg1Of generation,the
R7766 T9260 T9261 arg1Of generation,of
R7767 T9264 T9261 arg2Of complex,of
R7768 T9264 T9262 arg1Of complex,the
R7769 T9264 T9263 arg1Of complex,IκB-α/NF-κB
R7770 T9267 T9265 arg2Of end,To
R7771 T9267 T9266 arg1Of end,this
R7772 T9270 T9269 arg1Of association,the
R7773 T9270 T9271 arg1Of association,of
R7774 T9270 T9273 arg1Of association,with
R7775 T9270 T9275 arg1Of association,was
R7776 T9270 T9276 arg2Of association,analysed
R7777 T9272 T9271 arg2Of IκB-α,of
R7778 T9274 T9273 arg2Of p65,with
R7779 T9276 T9265 arg1Of analysed,To
R7780 T9276 T9268 arg1Of analysed,","
R7781 T9276 T9275 arg2Of analysed,was
R7782 T9276 T9278 arg1Of analysed,vivo
R7783 T9276 T9279 arg1Of analysed,at
R7784 T9276 T9283 arg1Of analysed,after
R7785 T9278 T9277 arg1Of vivo,in
R7786 T9280 T9281 arg1Of 0,and
R7787 T9281 T9279 arg2Of and,at
R7788 T9282 T9281 arg2Of 240 min,and
R7789 T9285 T9283 arg2Of PMA,after
R7790 T9285 T9284 arg1Of PMA,short-pulse
R7791 T9285 T9286 arg1Of PMA,","
R7792 T9285 T9287 arg1Of PMA,which
R7793 T9285 T9288 arg1Of PMA,corresponded
R7794 T9288 T9289 arg1Of corresponded,to
R7795 T9288 T9302 arg1Of corresponded,","
R7796 T9288 T9303 arg1Of corresponded,respectively
R7797 T9291 T9289 arg2Of time,to
R7798 T9291 T9290 arg1Of time,the
R7799 T9291 T9292 arg1Of time,of
R7800 T9294 T9293 arg1Of condition,un-stimulated
R7801 T9294 T9295 arg1Of condition,and
R7802 T9295 T9292 arg2Of and,of
R7803 T9298 T9297 arg1Of novo,de
R7804 T9299 T9295 arg2Of synthesis,and
R7805 T9299 T9296 arg1Of synthesis,post-activation
R7806 T9299 T9298 arg1Of synthesis,novo
R7807 T9299 T9300 arg1Of synthesis,of
R7808 T9301 T9300 arg2Of IκB-α,of
R7809 T9304 T9305 arg1Of Coimmunoprecipitation,of
R7810 T9304 T9307 arg1Of Coimmunoprecipitation,with
R7811 T9304 T9309 arg1Of Coimmunoprecipitation,was
R7812 T9304 T9310 arg2Of Coimmunoprecipitation,detected
R7813 T9304 T9330 arg1Of Coimmunoprecipitation,was
R7814 T9304 T9331 arg2Of Coimmunoprecipitation,halved
R7815 T9306 T9305 arg2Of IκB-α,of
R7816 T9308 T9307 arg2Of p65,with
R7817 T9310 T9309 arg2Of detected,was
R7818 T9310 T9311 arg1Of detected,at
R7819 T9310 T9329 arg1Of detected,and
R7820 T9312 T9313 arg1Of 0-,and
R7821 T9313 T9311 arg2Of and,at
R7822 T9314 T9313 arg2Of 240-min,and
R7823 T9314 T9315 arg1Of 240-min,post-treatment
R7824 T9315 T9316 arg1Of post-treatment,in
R7825 T9318 T9316 arg2Of cells,in
R7826 T9318 T9317 arg1Of cells,Tat-negative
R7827 T9318 T9319 arg1Of cells,(
R7828 T9321 T9319 arg2Of 2D,(
R7829 T9321 T9320 arg1Of 2D,Figure
R7830 T9321 T9322 arg1Of 2D,","
R7831 T9324 T9325 arg1Of 1,and
R7832 T9325 T9322 arg2Of and,","
R7833 T9325 T9323 arg1Of and,lanes
R7834 T9326 T9325 arg2Of 3,and
R7835 T9327 T9319 arg3Of ),(
R7836 T9329 T9328 arg1Of and,","
R7837 T9329 T9350 arg1Of and,","
R7838 T9329 T9351 modOf and,indicating
R7839 T9331 T9329 arg2Of halved,and
R7840 T9331 T9330 arg2Of halved,was
R7841 T9331 T9332 arg1Of halved,in
R7842 T9334 T9332 arg2Of cells,in
R7843 T9334 T9333 arg1Of cells,Tat-positive
R7844 T9334 T9335 arg1Of cells,","
R7845 T9334 T9336 arg1Of cells,where
R7846 T9334 T9341 arg1Of cells,(
R7847 T9337 T9338 arg1Of Tat,coimmunoprecipitated
R7848 T9338 T9336 arg2Of coimmunoprecipitated,where
R7849 T9338 T9339 arg1Of coimmunoprecipitated,with
R7850 T9340 T9339 arg2Of IκB-α,with
R7851 T9343 T9341 arg2Of 2D,(
R7852 T9343 T9342 arg1Of 2D,Figure
R7853 T9343 T9344 arg1Of 2D,","
R7854 T9346 T9347 arg1Of 2,and
R7855 T9347 T9344 arg2Of and,","
R7856 T9347 T9345 arg1Of and,lanes
R7857 T9348 T9347 arg2Of 4,and
R7858 T9349 T9341 arg3Of ),(
R7859 T9353 T9354 arg1Of Tat,competed
R7860 T9354 T9351 arg2Of competed,indicating
R7861 T9354 T9352 arg1Of competed,that
R7862 T9357 T9354 arg2Of binding,competed
R7863 T9357 T9355 arg1Of binding,the
R7864 T9357 T9356 arg1Of binding,IκB-α
R7865 T9357 T9358 arg1Of binding,to
R7866 T9359 T9358 arg2Of p65,to
R9460 T11613 T11614 arg1Of Tat,counteracts
R9461 T11613 T11621 arg1Of Tat,competing
R9462 T11614 T11620 arg1Of counteracts,by
R9463 T11617 T11614 arg2Of inhibition,counteracts
R9464 T11617 T11615 arg1Of inhibition,the
R9465 T11617 T11616 arg1Of inhibition,IκB-α
R9466 T11617 T11618 arg1Of inhibition,of
R9467 T11619 T11618 arg2Of p65,of
R9468 T11621 T11620 arg2Of competing,by
R9469 T11624 T11621 arg2Of binding,competing
R9470 T11624 T11622 arg1Of binding,the
R9471 T11624 T11623 arg1Of binding,repressor
R9472 T11625 T11627 arg1Of We,investigated
R9473 T11627 T11626 arg1Of investigated,further
R9474 T11630 T11627 arg2Of interaction,investigated
R9475 T11630 T11628 arg1Of interaction,the
R9476 T11630 T11629 arg1Of interaction,physical
R9477 T11630 T11631 arg1Of interaction,of
R9478 T11630 T11633 arg1Of interaction,with
R9479 T11632 T11631 arg2Of Tat,of
R9480 T11634 T11633 arg2Of IκB-α,with
R9481 T11634 T11635 arg1Of IκB-α,using
R9482 T11635 T11640 arg1Of using,in
R9483 T11637 T11636 arg1Of vitro,in
R9484 T11639 T11635 arg2Of proteins,using
R9485 T11639 T11637 arg1Of proteins,vitro
R9486 T11639 T11638 arg2Of proteins,translated
R9487 T11642 T11640 arg2Of assays,in
R9488 T11642 T11641 arg1Of assays,coimmunoprecipitation
R9489 T11644 T11643 arg2Of mapping,For
R9490 T11647 T11644 arg2Of domains,mapping
R9491 T11647 T11645 arg1Of domains,the
R9492 T11647 T11646 arg1Of domains,interaction
R9493 T11649 T11650 arg1Of we,used
R9494 T11650 T11643 arg1Of used,For
R9495 T11650 T11648 arg1Of used,","
R9496 T11650 T11655 arg1Of used,:
R9497 T11654 T11650 arg2Of mutants,used
R9498 T11654 T11651 arg1Of mutants,the
R9499 T11654 T11652 arg1Of mutants,following
R9500 T11654 T11653 arg1Of mutants,Tat
R9501 T11657 T11656 arg1Of T,Tat
R9502 T11657 T11658 arg1Of T,","
R9503 T11657 T11664 arg1Of T,","
R9504 T11661 T11660 arg2Of "23,24",(
R9505 T11662 T11660 arg3Of ),(
R9506 T11663 T11658 arg2Of A,","
R9507 T11663 T11659 arg1Of A,N
R9508 T11663 T11660 arg1Of A,(
R9509 T11664 T11671 arg1Of ",",","
R9510 T11668 T11667 arg2Of "22,25,27",(
R9511 T11669 T11667 arg3Of ),(
R9512 T11670 T11664 arg2Of A,","
R9513 T11670 T11665 arg1Of A,Tat
R9514 T11670 T11666 arg1Of A,C
R9515 T11670 T11667 arg1Of A,(
R9516 T11675 T11674 arg2Of "50,51",(
R9517 T11676 T11674 arg3Of ),(
R9518 T11677 T11672 arg1Of A,Tat
R9519 T11677 T11673 arg1Of A,K
R9520 T11677 T11674 arg1Of A,(
R9521 T11677 T11678 arg1Of A,and
R9522 T11678 T11671 arg2Of and,","
R9523 T11680 T11679 arg1Of R,Tat
R9524 T11680 T11681 arg1Of R,(
R9525 T11682 T11681 arg2Of 49–57,(
R9526 T11683 T11681 arg3Of ),(
R9527 T11684 T11678 arg2Of A,and
R9528 T11684 T11680 arg1Of A,R
R9529 T11684 T11685 arg1Of A,(
R9530 T11687 T11685 arg2Of 3A,(
R9531 T11687 T11686 arg1Of 3A,Figure
R9532 T11688 T11685 arg3Of ),(
R9533 T11689 T11690 arg1Of IκB-α,coimmunoprecipitated
R9534 T11690 T11691 arg1Of coimmunoprecipitated,with
R9535 T11690 T11695 arg1Of coimmunoprecipitated,","
R9536 T11694 T11691 arg2Of proteins,with
R9537 T11694 T11692 arg1Of proteins,all
R9538 T11694 T11693 arg1Of proteins,Tat
R9539 T11698 T11697 arg1Of R,Tat
R9540 T11698 T11699 arg1Of R,(
R9541 T11700 T11699 arg2Of 49–57,(
R9542 T11701 T11699 arg3Of ),(
R9543 T11702 T11690 arg2Of A,coimmunoprecipitated
R9544 T11702 T11696 arg1Of A,except
R9545 T11702 T11698 arg1Of A,R
R9546 T11702 T11703 arg1Of A,(
R9547 T11705 T11703 arg2Of 3B,(
R9548 T11705 T11704 arg1Of 3B,Figure
R9549 T11706 T11703 arg3Of ),(
R9550 T11708 T11707 arg1Of results,These
R9551 T11708 T11709 arg1Of results,indicated
R9552 T11713 T11711 arg1Of domain,the
R9553 T11713 T11712 arg1Of domain,arginine-rich
R9554 T11713 T11714 arg1Of domain,of
R9555 T11713 T11716 arg1Of domain,was
R9556 T11713 T11717 arg2Of domain,involved
R9557 T11715 T11714 arg2Of Tat,of
R9558 T11717 T11709 arg2Of involved,indicated
R9559 T11717 T11710 arg1Of involved,that
R9560 T11717 T11716 arg2Of involved,was
R9561 T11717 T11718 arg1Of involved,in
R9562 T11720 T11718 arg2Of binding,in
R9563 T11720 T11719 arg1Of binding,the
R9564 T11720 T11721 arg1Of binding,to
R9565 T11720 T11723 arg1Of binding,","
R9566 T11720 T11724 arg1Of binding,which
R9567 T11720 T11725 arg1Of binding,was
R9568 T11720 T11726 arg1Of binding,consistent
R9569 T11722 T11721 arg2Of IκB-α,to
R9570 T11726 T11725 arg2Of consistent,was
R9571 T11726 T11727 arg1Of consistent,with
R9572 T11729 T11727 arg2Of observations,with
R9573 T11729 T11728 arg1Of observations,previous
R9574 T11729 T11730 arg1Of observations,(
R9575 T11731 T11730 arg2Of "50,51",(
R9576 T11732 T11730 arg3Of ),(
R9577 T11735 T11736 arg1Of Tat,associating
R9578 T11735 T11739 arg1Of Tat,competed
R9579 T11736 T11737 arg1Of associating,with
R9580 T11738 T11737 arg2Of IκB-α,with
R9581 T11739 T11733 arg1Of competed,Moreover
R9582 T11739 T11734 arg1Of competed,","
R9583 T11739 T11757 arg1Of competed,","
R9584 T11739 T11758 arg1Of competed,while
R9585 T11741 T11739 arg2Of binding,competed
R9586 T11741 T11740 arg1Of binding,the
R9587 T11741 T11742 arg1Of binding,of
R9588 T11741 T11744 arg1Of binding,to
R9589 T11741 T11746 arg1Of binding,in
R9590 T11743 T11742 arg2Of IκB-α,of
R9591 T11745 T11744 arg2Of p65,to
R9592 T11749 T11746 arg2Of manner,in
R9593 T11749 T11747 arg1Of manner,a
R9594 T11749 T11748 arg1Of manner,dose-dependent
R9595 T11749 T11750 arg1Of manner,(
R9596 T11752 T11750 arg2Of 3C,(
R9597 T11752 T11751 arg1Of 3C,Figure
R9598 T11752 T11753 arg1Of 3C,","
R9599 T11754 T11753 arg2Of lanes,","
R9600 T11754 T11755 arg1Of lanes,3–5
R9601 T11756 T11750 arg3Of ),(
R9602 T11760 T11759 arg1Of R,Tat
R9603 T11760 T11761 arg1Of R,(
R9604 T11762 T11761 arg2Of 49–57,(
R9605 T11763 T11761 arg3Of ),(
R9606 T11764 T11760 arg1Of A,R
R9607 T11764 T11765 arg1Of A,","
R9608 T11764 T11766 arg1Of A,which
R9609 T11764 T11767 arg1Of A,lacked
R9610 T11764 T11774 arg1Of A,did
R9611 T11764 T11776 arg1Of A,associate
R9612 T11764 T11780 arg1Of A,did
R9613 T11764 T11782 arg1Of A,compete
R9614 T11770 T11767 arg2Of site,lacked
R9615 T11770 T11768 arg1Of site,the
R9616 T11770 T11769 arg1Of site,binding
R9617 T11770 T11771 arg1Of site,for
R9618 T11772 T11771 arg2Of IκB-α,for
R9619 T11776 T11774 arg2Of associate,did
R9620 T11776 T11775 arg1Of associate,not
R9621 T11776 T11777 arg1Of associate,with
R9622 T11776 T11779 arg1Of associate,and
R9623 T11778 T11777 arg2Of IκB-α,with
R9624 T11779 T11758 arg2Of and,while
R9625 T11779 T11773 arg1Of and,","
R9626 T11782 T11779 arg2Of compete,and
R9627 T11782 T11780 arg2Of compete,did
R9628 T11782 T11781 arg1Of compete,not
R9629 T11784 T11782 arg2Of binding,compete
R9630 T11784 T11783 arg1Of binding,the
R9631 T11784 T11785 arg1Of binding,of
R9632 T11784 T11787 arg1Of binding,to
R9633 T11786 T11785 arg2Of IκB-α,of
R9634 T11788 T11787 arg2Of p65,to
R9635 T11788 T11789 arg1Of p65,(
R9636 T11791 T11789 arg2Of 3C,(
R9637 T11791 T11790 arg1Of 3C,Figure
R9638 T11791 T11792 arg1Of 3C,","
R9639 T11793 T11792 arg2Of lanes,","
R9640 T11793 T11794 arg1Of lanes,6–8
R9641 T11795 T11789 arg3Of ),(
R9642 T11798 T11799 arg1Of we,evaluated
R9643 T11799 T11796 arg1Of evaluated,Next
R9644 T11799 T11797 arg1Of evaluated,","
R9645 T11801 T11802 arg1Of Tat,counteracted
R9646 T11801 T11812 arg1Of Tat,incubating
R9647 T11802 T11799 arg2Of counteracted,evaluated
R9648 T11802 T11800 arg1Of counteracted,whether
R9649 T11802 T11811 arg1Of counteracted,by
R9650 T11805 T11802 arg2Of inhibition,counteracted
R9651 T11805 T11803 arg1Of inhibition,the
R9652 T11805 T11804 arg1Of inhibition,IκB-α-mediated
R9653 T11805 T11806 arg1Of inhibition,of
R9654 T11805 T11809 arg1Of inhibition,to
R9655 T11808 T11806 arg2Of binding,of
R9656 T11808 T11807 arg1Of binding,p65
R9657 T11810 T11809 arg2Of DNA,to
R9658 T11812 T11811 arg2Of incubating,by
R9659 T11812 T11824 arg1Of incubating,in
R9660 T11814 T11813 arg1Of vitro,in
R9661 T11816 T11815 arg2Of p65,translated
R9662 T11816 T11817 arg1Of p65,and
R9663 T11817 T11812 arg2Of and,incubating
R9664 T11817 T11814 arg1Of and,vitro
R9665 T11817 T11820 arg1Of and,with
R9666 T11819 T11817 arg2Of proteins,and
R9667 T11819 T11818 arg1Of proteins,IκB-α
R9668 T11823 T11820 arg2Of probe,with
R9669 T11823 T11821 arg1Of probe,the
R9670 T11823 T11822 arg1Of probe,NF-κB
R9671 T11825 T11826 arg1Of presence,or
R9672 T11826 T11824 arg2Of or,in
R9673 T11826 T11828 arg1Of or,of
R9674 T11827 T11826 arg2Of absence,or
R9675 T11829 T11828 arg2Of Tat,of
R9676 T11829 T11830 arg2Of Tat,followed
R9677 T11832 T11830 arg1Of EMSA,followed
R9678 T11832 T11831 arg2Of EMSA,by
R9679 T11837 T11833 arg1Of activity,The
R9680 T11837 T11834 arg1Of activity,p65
R9681 T11837 T11835 arg1Of activity,DNA
R9682 T11837 T11836 arg1Of activity,binding
R9683 T11837 T11838 arg1Of activity,was
R9684 T11837 T11839 arg2Of activity,inhibited
R9685 T11837 T11843 arg2Of activity,restored
R9686 T11839 T11842 arg1Of inhibited,and
R9687 T11841 T11839 arg1Of IκB-α,inhibited
R9688 T11841 T11840 arg2Of IκB-α,by
R9689 T11842 T11838 arg2Of and,was
R9690 T11843 T11842 arg2Of restored,and
R9691 T11843 T11844 arg1Of restored,in
R9692 T11843 T11848 arg1Of restored,by
R9693 T11843 T11854 arg1Of restored,by
R9694 T11847 T11844 arg2Of manner,in
R9695 T11847 T11845 arg1Of manner,a
R9696 T11847 T11846 arg1Of manner,dose-dependent
R9697 T11848 T11852 arg1Of by,and
R9698 T11850 T11848 arg2Of Tat,by
R9699 T11850 T11849 arg1Of Tat,wild-type
R9700 T11852 T11851 arg1Of and,","
R9701 T11854 T11852 arg2Of by,and
R9702 T11854 T11853 arg1Of by,not
R9703 T11856 T11854 arg2Of R,by
R9704 T11856 T11855 arg1Of R,Tat
R9705 T11856 T11857 arg1Of R,(
R9706 T11856 T11860 arg1Of R,(
R9707 T11858 T11857 arg2Of 49–57,(
R9708 T11859 T11857 arg3Of ),(
R9709 T11862 T11860 arg2Of 3D,(
R9710 T11862 T11861 arg1Of 3D,Figure
R9711 T11863 T11860 arg3Of ),(
R9712 T11866 T11867 arg1Of we,analysed
R9713 T11866 T11880 arg1Of we,transfecting
R9714 T11867 T11864 arg1Of analysed,Further
R9715 T11867 T11865 arg1Of analysed,","
R9716 T11867 T11871 arg1Of analysed,on
R9717 T11867 T11879 arg1Of analysed,by
R9718 T11870 T11867 arg2Of effect,analysed
R9719 T11870 T11868 arg1Of effect,the
R9720 T11870 T11869 arg1Of effect,Tat
R9721 T11874 T11871 arg2Of repression,on
R9722 T11874 T11872 arg1Of repression,the
R9723 T11874 T11873 arg1Of repression,IκB-α
R9724 T11874 T11875 arg1Of repression,of
R9725 T11878 T11875 arg2Of activity,of
R9726 T11878 T11876 arg1Of activity,p65
R9727 T11878 T11877 arg1Of activity,transcriptional
R9728 T11880 T11879 arg2Of transfecting,by
R9729 T11880 T11882 arg1Of transfecting,with
R9730 T11880 T11886 arg1Of transfecting,together
R9731 T11880 T11887 arg1Of transfecting,with
R9732 T11880 T11894 arg1Of transfecting,","
R9733 T11880 T11895 arg1Of transfecting,in
R9734 T11881 T11880 arg2Of p50−/−p65−/−MEFs,transfecting
R9735 T11885 T11882 arg2Of reporter,with
R9736 T11885 T11883 arg1Of reporter,the
R9737 T11885 T11884 arg1Of reporter,NF-κB-Luc
R9738 T11889 T11887 arg2Of vectors,with
R9739 T11889 T11888 arg1Of vectors,expression
R9740 T11889 T11890 arg1Of vectors,of
R9741 T11891 T11892 arg1Of p65,and
R9742 T11892 T11890 arg2Of and,of
R9743 T11893 T11892 arg2Of IκB-α,and
R9744 T11896 T11897 arg1Of presence,or
R9745 T11897 T11899 arg1Of or,of
R9746 T11897 T11902 arg1Of or,inhibited
R9747 T11898 T11897 arg2Of absence,or
R9748 T11901 T11899 arg2Of IκB-α,of
R9749 T11901 T11900 arg1Of IκB-α,Tat.
R9750 T11902 T11895 arg2Of inhibited,in
R9751 T11905 T11902 arg2Of expression,inhibited
R9752 T11905 T11903 arg1Of expression,the
R9753 T11905 T11904 arg1Of expression,p65-dependent
R9754 T11905 T11906 arg1Of expression,of
R9755 T11905 T11924 arg1Of expression,by
R9756 T11906 T11922 arg1Of of,and
R9757 T11909 T11906 arg2Of gene,of
R9758 T11909 T11907 arg1Of gene,the
R9759 T11909 T11908 arg1Of gene,luciferase
R9760 T11909 T11910 arg1Of gene,","
R9761 T11909 T11911 arg1Of gene,which
R9762 T11909 T11912 arg1Of gene,was
R9763 T11909 T11913 arg2Of gene,restored
R9764 T11913 T11912 arg2Of restored,was
R9765 T11913 T11914 arg1Of restored,in
R9766 T11917 T11914 arg2Of manner,in
R9767 T11917 T11915 arg1Of manner,a
R9768 T11917 T11916 arg1Of manner,dose-dependent
R9769 T11920 T11913 arg1Of Tat,restored
R9770 T11920 T11918 arg2Of Tat,by
R9771 T11920 T11919 arg1Of Tat,wild-type
R9772 T11922 T11921 arg1Of and,","
R9773 T11924 T11922 arg2Of by,and
R9774 T11924 T11923 arg1Of by,not
R9775 T11926 T11925 arg1Of R,Tat
R9776 T11926 T11927 arg1Of R,(
R9777 T11928 T11927 arg2Of 49–57,(
R9778 T11929 T11927 arg3Of ),(
R9779 T11930 T11924 arg2Of A,by
R9780 T11930 T11926 arg1Of A,R
R9781 T11930 T11931 arg1Of A,(
R9782 T11933 T11931 arg2Of 3E,(
R9783 T11933 T11932 arg1Of 3E,Figure
R9784 T11934 T11931 arg3Of ),(
R9785 T11937 T11936 arg1Of results,these
R9786 T11937 T11938 arg1Of results,indicated
R9787 T11938 T11935 arg1Of indicated,Altogether
R9788 T11940 T11941 arg1Of Tat,counteracts
R9789 T11940 T11953 arg1Of Tat,associating
R9790 T11940 T11957 arg1Of Tat,competing
R9791 T11941 T11938 arg2Of counteracts,indicated
R9792 T11941 T11939 arg1Of counteracts,that
R9793 T11941 T11952 arg1Of counteracts,by
R9794 T11944 T11941 arg2Of repression,counteracts
R9795 T11944 T11942 arg1Of repression,the
R9796 T11944 T11943 arg1Of repression,IκB-α
R9797 T11944 T11945 arg1Of repression,of
R9798 T11948 T11949 arg1Of DNA-binding,and
R9799 T11950 T11949 arg2Of transcriptional,and
R9800 T11951 T11945 arg2Of activity,of
R9801 T11951 T11946 arg1Of activity,the
R9802 T11951 T11947 arg1Of activity,p65
R9803 T11951 T11948 arg1Of activity,DNA-binding
R9804 T11951 T11950 arg1Of activity,transcriptional
R9805 T11953 T11954 arg1Of associating,with
R9806 T11953 T11956 arg1Of associating,and
R9807 T11955 T11954 arg2Of IκB-α,with
R9808 T11956 T11952 arg2Of and,by
R9809 T11957 T11956 arg2Of competing,and
R9810 T11960 T11957 arg2Of binding,competing
R9811 T11960 T11958 arg1Of binding,the
R9812 T11960 T11959 arg1Of binding,repressor
R9813 T11960 T11961 arg1Of binding,to
R9814 T11962 T11961 arg2Of p65,to
R10763 T13335 T13336 arg1Of Tat,increases
R10764 T13336 T13343 arg1Of increases,through
R10765 T13340 T13336 arg2Of binding,increases
R10766 T13340 T13337 arg1Of binding,the
R10767 T13340 T13338 arg1Of binding,p65
R10768 T13340 T13339 arg1Of binding,affinity
R10769 T13340 T13341 arg1Of binding,to
R10770 T13342 T13341 arg2Of DNA,to
R10772 T13344 T13343 arg2Of association,through
R10773 T13346 T13345 arg2Of p65,with
R10774 T13347 T13348 arg1Of We,tested
R10775 T13350 T13352 arg1Of Tat,interacted
R10776 T13352 T13348 arg2Of interacted,tested
R10777 T13352 T13349 arg1Of interacted,whether
R10778 T13352 T13351 arg1Of interacted,physically
R10779 T13352 T13353 arg1Of interacted,with
R10780 T13354 T13353 arg2Of p65,with
R10781 T13356 T13355 arg1Of cells,HeLa
R10782 T13356 T13357 arg1Of cells,were
R10783 T13356 T13358 arg2Of cells,transfected
R10784 T13358 T13357 arg2Of transfected,were
R10785 T13358 T13359 arg1Of transfected,with
R10786 T13358 T13368 arg1Of transfected,and
R10787 T13362 T13359 arg2Of vectors,with
R10788 T13362 T13360 arg1Of vectors,the
R10789 T13362 T13361 arg1Of vectors,expression
R10790 T13362 T13363 arg1Of vectors,of
R10791 T13364 T13365 arg1Of HA-p65,and
R10792 T13365 T13363 arg2Of and,of
R10793 T13366 T13365 arg2Of FLAG-Tat,and
R10794 T13368 T13367 arg1Of and,","
R10795 T13371 T13369 arg1Of Tat,24 h
R10796 T13371 T13370 arg1Of Tat,later
R10797 T13371 T13372 arg1Of Tat,was
R10798 T13371 T13373 arg2Of Tat,immunoprecipitated
R10799 T13373 T13368 arg2Of immunoprecipitated,and
R10800 T13373 T13372 arg2Of immunoprecipitated,was
R10801 T13373 T13374 arg1Of immunoprecipitated,from
R10802 T13376 T13374 arg2Of extracts,from
R10803 T13376 T13375 arg1Of extracts,cell
R10804 T13379 T13377 arg1Of protein,The
R10805 T13379 T13378 arg1Of protein,p65
R10806 T13379 T13380 arg1Of protein,was
R10807 T13379 T13381 arg2Of protein,coimmunoprecipitated
R10808 T13381 T13380 arg2Of coimmunoprecipitated,was
R10809 T13381 T13382 arg1Of coimmunoprecipitated,with
R10810 T13381 T13410 arg1Of coimmunoprecipitated,at
R10811 T13381 T13413 arg1Of coimmunoprecipitated,","
R10812 T13381 T13414 arg1Of coimmunoprecipitated,while
R10813 T13384 T13383 arg1Of Tat,wild-type
R10814 T13384 T13385 arg1Of Tat,or
R10815 T13385 T13390 arg1Of or,","
R10816 T13387 T13386 arg1Of mutants,the
R10817 T13389 T13385 arg2Of T,or
R10818 T13389 T13387 arg1Of T,mutants
R10819 T13389 T13388 arg1Of T,Tat
R10820 T13390 T13396 arg1Of ",",","
R10821 T13393 T13392 arg2Of "23,24",(
R10822 T13394 T13392 arg3Of ),(
R10823 T13395 T13390 arg2Of A,","
R10824 T13395 T13391 arg1Of A,N
R10825 T13395 T13392 arg1Of A,(
R10826 T13396 T13403 arg1Of ",",and
R10827 T13400 T13399 arg2Of "50,51",(
R10828 T13401 T13399 arg3Of ),(
R10829 T13402 T13396 arg2Of A,","
R10830 T13402 T13397 arg1Of A,Tat
R10831 T13402 T13398 arg1Of A,K
R10832 T13402 T13399 arg1Of A,(
R10833 T13403 T13382 arg2Of and,with
R10834 T13405 T13404 arg1Of R,Tat
R10835 T13405 T13406 arg1Of R,(
R10836 T13407 T13406 arg2Of 49–57,(
R10837 T13408 T13406 arg3Of ),(
R10838 T13409 T13403 arg2Of A,and
R10839 T13409 T13405 arg1Of A,R
R10840 T13412 T13410 arg2Of levels,at
R10841 T13412 T13411 arg1Of levels,similar
R10842 T13417 T13415 arg1Of decrease,a
R10843 T13417 T13416 arg1Of decrease,significant
R10844 T13417 T13418 arg1Of decrease,in
R10845 T13417 T13420 arg1Of decrease,was
R10846 T13417 T13421 arg2Of decrease,observed
R10847 T13419 T13418 arg2Of coimmunoprecipitation,in
R10848 T13421 T13414 arg2Of observed,while
R10849 T13421 T13420 arg2Of observed,was
R10850 T13421 T13422 arg1Of observed,for
R10851 T13426 T13425 arg2Of "22,25,27",(
R10852 T13427 T13425 arg3Of ),(
R10853 T13428 T13422 arg2Of A,for
R10854 T13428 T13423 arg1Of A,Tat
R10855 T13428 T13424 arg1Of A,C
R10856 T13428 T13425 arg1Of A,(
R10857 T13428 T13429 arg1Of A,(
R10858 T13431 T13429 arg2Of 4A,(
R10859 T13431 T13430 arg1Of 4A,Figure
R10860 T13432 T13429 arg3Of ),(
R10861 T13435 T13442 arg1Of GST-pull,showed
R10862 T13436 T13437 arg1Of down,of
R10863 T13441 T13436 arg2Of proteins,down
R10864 T13441 T13438 arg1Of proteins,in
R10865 T13441 T13439 arg1Of proteins,vitro
R10866 T13441 T13440 arg2Of proteins,translated
R10867 T13442 T13433 arg1Of showed,Consistently
R10868 T13442 T13434 arg1Of showed,","
R10869 T13442 T13436 arg1Of showed,down
R10870 T13445 T13444 arg1Of binding,direct
R10871 T13445 T13446 arg1Of binding,of
R10872 T13445 T13448 arg1Of binding,to
R10873 T13445 T13452 arg1Of binding,or
R10874 T13447 T13446 arg2Of p65,of
R10875 T13450 T13448 arg2Of Tat,to
R10876 T13450 T13449 arg1Of Tat,wild-type
R10877 T13452 T13451 arg1Of or,","
R10878 T13452 T13478 arg1Of or,and
R10879 T13454 T13453 arg1Of mutants,the
R10880 T13456 T13455 arg1Of T,Tat
R10881 T13456 T13457 arg1Of T,","
R10882 T13457 T13463 arg1Of ",",","
R10883 T13460 T13459 arg2Of "23,24",(
R10884 T13461 T13459 arg3Of ),(
R10885 T13462 T13457 arg2Of A,","
R10886 T13462 T13458 arg1Of A,N
R10887 T13462 T13459 arg1Of A,(
R10888 T13463 T13470 arg1Of ",",and
R10889 T13467 T13466 arg2Of "50,51",(
R10890 T13468 T13466 arg3Of ),(
R10891 T13469 T13463 arg2Of A,","
R10892 T13469 T13464 arg1Of A,Tat
R10893 T13469 T13465 arg1Of A,K
R10894 T13469 T13466 arg1Of A,(
R10895 T13470 T13452 arg2Of and,or
R10896 T13470 T13454 arg1Of and,mutants
R10897 T13472 T13471 arg1Of R,Tat
R10898 T13472 T13473 arg1Of R,(
R10899 T13474 T13473 arg2Of 49–57,(
R10900 T13475 T13473 arg3Of ),(
R10901 T13476 T13470 arg2Of A,and
R10902 T13476 T13472 arg1Of A,R
R10903 T13478 T13442 arg2Of and,showed
R10904 T13478 T13443 arg1Of and,the
R10905 T13478 T13477 arg1Of and,","
R10906 T13479 T13478 arg2Of lack,and
R10907 T13479 T13480 arg1Of lack,of
R10908 T13481 T13480 arg2Of binding,of
R10909 T13481 T13482 arg1Of binding,to
R10910 T13486 T13485 arg2Of "22,25,27",(
R10911 T13487 T13485 arg3Of ),(
R10912 T13488 T13482 arg2Of A,to
R10913 T13488 T13483 arg1Of A,Tat
R10914 T13488 T13484 arg1Of A,C
R10915 T13488 T13485 arg1Of A,(
R10916 T13488 T13489 arg1Of A,(
R10917 T13491 T13489 arg2Of 4B,(
R10918 T13491 T13490 arg1Of 4B,Figure
R10919 T13492 T13489 arg3Of ),(
R10920 T13494 T13493 arg1Of results,These
R10921 T13494 T13495 arg1Of results,indicated
R10922 T13497 T13498 arg1Of Tat,associated
R10923 T13498 T13495 arg2Of associated,indicated
R10924 T13498 T13496 arg1Of associated,that
R10925 T13498 T13499 arg1Of associated,with
R10926 T13500 T13501 arg1Of p65,through
R10927 T13500 T13505 arg1Of p65,and
R10928 T13504 T13501 arg2Of domain,through
R10929 T13504 T13502 arg1Of domain,the
R10930 T13504 T13503 arg1Of domain,cysteine-rich
R10931 T13505 T13499 arg2Of and,with
R10932 T13506 T13505 arg2Of ruled-out,and
R10933 T13508 T13506 arg2Of requirement,ruled-out
R10934 T13508 T13507 arg1Of requirement,the
R10935 T13508 T13509 arg1Of requirement,of
R10936 T13510 T13509 arg2Of bridging,of
R10937 T13510 T13512 modOf bridging,to
R10938 T13511 T13510 arg2Of proteins,bridging
R10939 T13513 T13512 arg1Of mediate,to
R10940 T13515 T13513 arg2Of interaction,mediate
R10941 T13515 T13514 arg1Of interaction,such
R10942 T13517 T13516 arg1Of identify,To
R10943 T13520 T13517 arg2Of domain,identify
R10944 T13520 T13518 arg1Of domain,the
R10945 T13520 T13519 arg1Of domain,p65
R10946 T13520 T13521 arg2Of domain,required
R10947 T13521 T13522 arg1Of required,for
R10948 T13523 T13522 arg2Of binding,for
R10949 T13523 T13524 arg1Of binding,to
R10950 T13525 T13524 arg2Of Tat,to
R10951 T13528 T13527 arg1Of cells,HeLa
R10952 T13528 T13529 arg1Of cells,were
R10953 T13528 T13530 arg2Of cells,transfected
R10954 T13530 T13516 modOf transfected,To
R10955 T13530 T13526 arg1Of transfected,","
R10956 T13530 T13529 arg2Of transfected,were
R10957 T13530 T13531 arg1Of transfected,with
R10958 T13532 T13531 arg2Of FLAG-Tat,with
R10959 T13532 T13534 arg1Of FLAG-Tat,with
R10960 T13532 T13561 arg1Of FLAG-Tat,(
R10961 T13534 T13533 arg1Of with,together
R10962 T13536 T13535 arg1Of mutants,HA-p65
R10963 T13536 T13537 arg1Of mutants,","
R10964 T13536 T13538 arg1Of mutants,which
R10965 T13536 T13539 arg1Of mutants,were
R10966 T13536 T13540 arg2Of mutants,deleted
R10967 T13536 T13552 arg1Of mutants,or
R10968 T13540 T13539 arg2Of deleted,were
R10969 T13540 T13541 arg1Of deleted,of
R10970 T13544 T13541 arg2Of domain,of
R10971 T13544 T13542 arg1Of domain,the
R10972 T13544 T13543 arg1Of domain,transactivation
R10973 T13544 T13545 arg1Of domain,[
R10974 T13546 T13545 arg2Of p65ΔC,[
R10975 T13546 T13547 arg1Of p65ΔC,(
R10976 T13548 T13547 arg2Of 1–318,(
R10977 T13549 T13547 arg3Of ),(
R10978 T13550 T13545 arg3Of ],[
R10979 T13552 T13534 arg2Of or,with
R10980 T13552 T13551 arg1Of or,","
R10981 T13554 T13552 arg2Of RHD,or
R10982 T13554 T13553 arg1Of RHD,the
R10983 T13554 T13555 arg1Of RHD,[
R10984 T13556 T13555 arg2Of p65ΔN,[
R10985 T13556 T13557 arg1Of p65ΔN,(
R10986 T13558 T13557 arg2Of 122–551,(
R10987 T13559 T13557 arg3Of ),(
R10988 T13560 T13555 arg3Of ],[
R10989 T13563 T13561 arg2Of 4C,(
R10990 T13563 T13562 arg1Of 4C,Figure
R10991 T13564 T13561 arg3Of ),(
R10992 T13565 T13566 arg1Of Tat,coimmunoprecipitated
R10993 T13566 T13567 arg1Of coimmunoprecipitated,with
R10994 T13566 T13575 arg1Of coimmunoprecipitated,with
R10995 T13566 T13584 arg1Of coimmunoprecipitated,","
R10996 T13566 T13585 modOf coimmunoprecipitated,indicating
R10997 T13567 T13573 arg1Of with,and
R10998 T13568 T13567 arg2Of p65ΔC,with
R10999 T13568 T13569 arg1Of p65ΔC,(
R11000 T13570 T13569 arg2Of 1–318,(
R11001 T13571 T13569 arg3Of ),(
R11002 T13573 T13572 arg1Of and,","
R11003 T13575 T13573 arg2Of with,and
R11004 T13575 T13574 arg1Of with,not
R11005 T13576 T13575 arg2Of p65ΔN,with
R11006 T13576 T13577 arg1Of p65ΔN,(
R11007 T13576 T13580 arg1Of p65ΔN,(
R11008 T13578 T13577 arg2Of 122–551,(
R11009 T13579 T13577 arg3Of ),(
R11010 T13582 T13580 arg2Of 4D,(
R11011 T13582 T13581 arg1Of 4D,Figure
R11012 T13583 T13580 arg3Of ),(
R11013 T13588 T13587 arg1Of RHD,the
R11014 T13588 T13589 arg1Of RHD,of
R11015 T13588 T13591 arg1Of RHD,was
R11016 T13588 T13592 arg2Of RHD,involved
R11017 T13590 T13589 arg2Of p65,of
R11018 T13592 T13585 arg2Of involved,indicating
R11019 T13592 T13586 arg1Of involved,that
R11020 T13592 T13591 arg2Of involved,was
R11021 T13592 T13593 arg1Of involved,in
R11022 T13596 T13593 arg2Of interaction,in
R11023 T13596 T13594 arg1Of interaction,the
R11024 T13596 T13595 arg1Of interaction,physical
R11025 T13596 T13597 arg1Of interaction,with
R11026 T13598 T13597 arg2Of Tat,with
R11027 T13600 T13599 arg1Of address,To
R11028 T13602 T13600 arg2Of effect,address
R11029 T13602 T13601 arg1Of effect,the
R11030 T13602 T13603 arg1Of effect,of
R11031 T13602 T13605 arg1Of effect,on
R11032 T13604 T13603 arg2Of Tat,of
R11033 T13609 T13605 arg2Of affinity,on
R11034 T13609 T13606 arg1Of affinity,the
R11035 T13609 T13607 arg1Of affinity,p65
R11036 T13609 T13608 arg1Of affinity,DNA-binding
R11037 T13614 T13600 arg1Of protein,address
R11038 T13614 T13611 arg2Of protein,purified
R11039 T13614 T13612 arg1Of protein,recombinant
R11040 T13614 T13613 arg1Of protein,p65
R11041 T13614 T13615 arg1Of protein,was
R11042 T13614 T13616 arg2Of protein,incubated
R11043 T13616 T13615 arg2Of incubated,was
R11044 T13616 T13617 arg1Of incubated,with
R11045 T13616 T13636 arg1Of incubated,and
R11046 T13620 T13617 arg2Of oligonucleotide,with
R11047 T13620 T13618 arg1Of oligonucleotide,32P-labeled-NF-κB
R11048 T13620 T13619 arg1Of oligonucleotide,double-stranded
R11049 T13620 T13621 arg1Of oligonucleotide,in
R11050 T13622 T13623 arg1Of presence,or
R11051 T13623 T13621 arg2Of or,in
R11052 T13623 T13625 arg1Of or,of
R11053 T13624 T13623 arg2Of absence,or
R11054 T13627 T13626 arg1Of Tat,wild-type
R11055 T13627 T13628 arg1Of Tat,or
R11056 T13628 T13625 arg2Of or,of
R11057 T13632 T13631 arg2Of "22,25,27",(
R11058 T13633 T13631 arg3Of ),(
R11059 T13634 T13628 arg2Of A,or
R11060 T13634 T13629 arg1Of A,Tat
R11061 T13634 T13630 arg1Of A,C
R11062 T13634 T13631 arg1Of A,(
R11063 T13636 T13599 modOf and,To
R11064 T13636 T13610 arg1Of and,","
R11065 T13636 T13635 arg1Of and,","
R11066 T13638 T13637 arg1Of DNA-binding,p65
R11067 T13638 T13639 arg1Of DNA-binding,was
R11068 T13638 T13640 arg2Of DNA-binding,analysed
R11069 T13640 T13636 arg2Of analysed,and
R11070 T13640 T13639 arg2Of analysed,was
R11071 T13642 T13640 arg1Of EMSA,analysed
R11072 T13642 T13641 arg2Of EMSA,by
R11073 T13645 T13644 arg1Of Tat,wild-type
R11074 T13645 T13647 arg1Of Tat,increased
R11075 T13647 T13643 arg2Of increased,Whereas
R11076 T13647 T13646 arg1Of increased,significantly
R11077 T13649 T13647 arg2Of binding,increased
R11078 T13649 T13648 arg1Of binding,the
R11079 T13649 T13650 arg1Of binding,of
R11080 T13649 T13652 arg1Of binding,to
R11081 T13651 T13650 arg2Of p65,of
R11082 T13653 T13652 arg2Of DNA,to
R11083 T13660 T13659 arg2Of "22,25,27",(
R11084 T13661 T13659 arg3Of ),(
R11085 T13662 T13655 arg1Of A,the
R11086 T13662 T13656 arg1Of A,mutant
R11087 T13662 T13657 arg1Of A,Tat
R11088 T13662 T13658 arg1Of A,C
R11089 T13662 T13659 arg1Of A,(
R11090 T13662 T13663 arg1Of A,","
R11091 T13662 T13671 arg1Of A,was
R11092 T13662 T13672 arg1Of A,ineffective
R11093 T13664 T13663 arg2Of lacking,","
R11094 T13667 T13664 arg2Of site,lacking
R11095 T13667 T13665 arg1Of site,the
R11096 T13667 T13666 arg1Of site,binding
R11097 T13667 T13668 arg1Of site,for
R11098 T13669 T13668 arg2Of p65,for
R11099 T13671 T13643 arg1Of was,Whereas
R11100 T13671 T13654 arg1Of was,","
R11101 T13671 T13670 arg1Of was,","
R11102 T13672 T13671 arg2Of ineffective,was
R11103 T13672 T13673 arg1Of ineffective,(
R11104 T13675 T13673 arg2Of 4E,(
R11105 T13675 T13674 arg1Of 4E,Figure
R11106 T13676 T13673 arg3Of ),(
R11107 T13679 T13677 arg1Of binding,The
R11108 T13679 T13678 arg1Of binding,p65
R11109 T13679 T13680 arg1Of binding,to
R11110 T13679 T13682 arg1Of binding,was
R11111 T13679 T13683 arg2Of binding,evaluated
R11112 T13681 T13680 arg2Of DNA,to
R11113 T13683 T13682 arg2Of evaluated,was
R11114 T13685 T13683 arg1Of competition,evaluated
R11115 T13685 T13684 arg2Of competition,by
R11116 T13685 T13686 arg1Of competition,with
R11117 T13688 T13686 arg2Of amounts,with
R11118 T13688 T13687 arg1Of amounts,increasing
R11119 T13688 T13689 arg1Of amounts,of
R11120 T13693 T13689 arg2Of oligonucleotide,of
R11121 T13693 T13690 arg1Of oligonucleotide,cold
R11122 T13693 T13691 arg1Of oligonucleotide,competitor
R11123 T13693 T13692 arg1Of oligonucleotide,NF-κB
R11124 T13693 T13694 arg1Of oligonucleotide,","
R11125 T13693 T13695 arg1Of oligonucleotide,which
R11126 T13693 T13696 arg1Of oligonucleotide,showed
R11127 T13698 T13700 arg1Of Tat,enhanced
R11128 T13700 T13696 arg2Of enhanced,showed
R11129 T13700 T13697 arg1Of enhanced,that
R11130 T13700 T13699 arg1Of enhanced,significantly
R11131 T13704 T13700 arg2Of binding,enhanced
R11132 T13704 T13701 arg1Of binding,the
R11133 T13704 T13702 arg1Of binding,p65
R11134 T13704 T13703 arg1Of binding,affinity
R11135 T13704 T13705 arg1Of binding,to
R11136 T13704 T13707 arg1Of binding,(
R11137 T13706 T13705 arg2Of DNA,to
R11138 T13709 T13708 arg1Of 4E,Figure
R11139 T13709 T13710 arg1Of 4E,and
R11140 T13710 T13707 arg2Of and,(
R11141 T13711 T13710 arg2Of F,and
R11142 T13712 T13707 arg3Of ),(
R12187 T15237 T15238 arg1Of Tat,activates
R12188 T15237 T15246 arg1Of Tat,occupies
R12189 T15237 T15251 arg1Of Tat,promotes
R12190 T15238 T15245 arg1Of activates,","
R12191 T15241 T15238 arg2Of expression,activates
R12192 T15241 T15239 arg1Of expression,the
R12193 T15241 T15240 arg1Of expression,p65-dependent
R12194 T15241 T15242 arg1Of expression,of
R12195 T15244 T15242 arg2Of genes,of
R12196 T15244 T15243 arg1Of genes,NF-κB-responsive
R12197 T15245 T15250 arg1Of ",",and
R12198 T15246 T15245 arg2Of occupies,","
R12199 T15249 T15246 arg2Of enhancers,occupies
R12200 T15249 T15247 arg1Of enhancers,the
R12201 T15249 T15248 arg1Of enhancers,NF-κB
R12202 T15251 T15250 arg2Of promotes,and
R12203 T15254 T15251 arg2Of recruitment,promotes
R12204 T15254 T15252 arg1Of recruitment,the
R12205 T15254 T15253 arg1Of recruitment,p65
R12206 T15254 T15255 arg1Of recruitment,with
R12207 T15257 T15255 arg2Of displacement,with
R12208 T15257 T15256 arg1Of displacement,IκB-α
R12209 T15258 T15259 arg1Of We,analysed
R12210 T15259 T15271 arg1Of analysed,vivo
R12211 T15261 T15259 arg2Of action,analysed
R12212 T15261 T15260 arg1Of action,the
R12213 T15261 T15262 arg1Of action,of
R12214 T15261 T15264 arg1Of action,on
R12215 T15263 T15262 arg2Of Tat,of
R12216 T15266 T15264 arg2Of expression,on
R12217 T15266 T15265 arg1Of expression,the
R12218 T15266 T15267 arg1Of expression,of
R12219 T15269 T15267 arg2Of genes,of
R12220 T15269 T15268 arg1Of genes,NF-κB-responsive
R12221 T15271 T15270 arg1Of vivo,in
R12222 T15274 T15272 arg2Of end,To
R12223 T15274 T15273 arg1Of end,this
R12224 T15277 T15276 arg1Of cells,HeLa
R12225 T15277 T15278 arg1Of cells,were
R12226 T15277 T15279 arg2Of cells,transfected
R12227 T15279 T15272 arg1Of transfected,To
R12228 T15279 T15275 arg1Of transfected,","
R12229 T15279 T15278 arg2Of transfected,were
R12230 T15279 T15280 arg1Of transfected,with
R12231 T15281 T15282 arg1Of FLAG-Tat,","
R12232 T15282 T15289 arg1Of ",",or
R12233 T15286 T15285 arg2Of "22,25,27",(
R12234 T15287 T15285 arg3Of ),(
R12235 T15288 T15282 arg2Of A,","
R12236 T15288 T15283 arg1Of A,FLAG-Tat
R12237 T15288 T15284 arg1Of A,C
R12238 T15288 T15285 arg1Of A,(
R12239 T15289 T15297 arg1Of or,and
R12240 T15291 T15290 arg1Of R,FLAG-Tat
R12241 T15291 T15292 arg1Of R,(
R12242 T15293 T15292 arg2Of 49–57,(
R12243 T15294 T15292 arg3Of ),(
R12244 T15295 T15289 arg2Of A,or
R12245 T15295 T15291 arg1Of A,R
R12246 T15297 T15280 arg2Of and,with
R12247 T15297 T15296 arg1Of and,","
R12248 T15298 T15297 arg2Of 48 h,and
R12249 T15298 T15308 modOf 48 h,was
R12250 T15301 T15299 arg1Of expression,later
R12251 T15301 T15300 arg1Of expression,the
R12252 T15301 T15302 arg1Of expression,of
R12253 T15301 T15308 arg1Of expression,was
R12254 T15301 T15309 arg2Of expression,analysed
R12255 T15304 T15302 arg2Of number,of
R12256 T15304 T15303 arg1Of number,a
R12257 T15304 T15305 arg1Of number,of
R12258 T15307 T15305 arg2Of genes,of
R12259 T15307 T15306 arg1Of genes,NF-κB-dependent
R12260 T15309 T15308 arg2Of analysed,was
R12261 T15312 T15309 arg1Of PCR,analysed
R12262 T15312 T15310 arg2Of PCR,by
R12263 T15312 T15311 arg1Of PCR,real-time
R12264 T15313 T15315 arg1Of Tat,increased
R12265 T15315 T15314 arg1Of increased,significantly
R12266 T15315 T15328 arg1Of increased,","
R12267 T15315 T15329 arg1Of increased,while
R12268 T15317 T15315 arg2Of expression,increased
R12269 T15317 T15316 arg1Of expression,the
R12270 T15317 T15318 arg1Of expression,of
R12271 T15319 T15320 arg1Of MIP-1α,","
R12272 T15320 T15322 arg1Of ",",","
R12273 T15321 T15320 arg2Of CSF3,","
R12274 T15322 T15324 arg1Of ",",","
R12275 T15323 T15322 arg2Of LTA,","
R12276 T15324 T15326 arg1Of ",",and
R12277 T15325 T15324 arg2Of NFKBIA,","
R12278 T15326 T15318 arg2Of and,of
R12279 T15327 T15326 arg2Of TLR2,and
R12280 T15335 T15334 arg2Of "22,25,27",(
R12281 T15336 T15334 arg3Of ),(
R12282 T15337 T15332 arg1Of A,Tat
R12283 T15337 T15333 arg1Of A,C
R12284 T15337 T15334 arg1Of A,(
R12285 T15337 T15338 arg1Of A,and
R12286 T15338 T15330 arg1Of and,the
R12287 T15338 T15331 arg1Of and,mutants
R12288 T15338 T15345 arg1Of and,were
R12289 T15338 T15346 arg1Of and,ineffective
R12290 T15340 T15339 arg1Of R,Tat
R12291 T15340 T15341 arg1Of R,(
R12292 T15342 T15341 arg2Of 49–57,(
R12293 T15343 T15341 arg3Of ),(
R12294 T15344 T15338 arg2Of A,and
R12295 T15344 T15340 arg1Of A,R
R12296 T15345 T15329 arg2Of were,while
R12297 T15346 T15345 arg2Of ineffective,were
R12298 T15346 T15347 arg1Of ineffective,(
R12299 T15349 T15347 arg2Of 5A–E,(
R12300 T15349 T15348 arg1Of 5A–E,Figure
R12301 T15350 T15347 arg3Of ),(
R12302 T15353 T15351 arg1Of transactivation,The
R12303 T15353 T15352 arg1Of transactivation,Tat-dependent
R12304 T15353 T15354 arg1Of transactivation,of
R12305 T15353 T15358 arg1Of transactivation,was
R12306 T15353 T15359 arg2Of transactivation,abolished
R12307 T15357 T15354 arg2Of genes,of
R12308 T15357 T15355 arg1Of genes,the
R12309 T15357 T15356 arg1Of genes,NF-κB-dependent
R12310 T15359 T15358 arg2Of abolished,was
R12311 T15359 T15360 arg1Of abolished,when
R12312 T15359 T15367 arg1Of abolished,","
R12313 T15359 T15368 modOf abolished,indicating
R12314 T15361 T15362 arg1Of cells,were
R12315 T15361 T15363 arg2Of cells,transfected
R12316 T15363 T15360 arg2Of transfected,when
R12317 T15363 T15362 arg2Of transfected,were
R12318 T15363 T15364 arg1Of transfected,with
R12319 T15366 T15364 arg2Of p65,with
R12320 T15366 T15365 arg1Of p65,siRNA
R12321 T15373 T15370 arg1Of activation,the
R12322 T15373 T15371 arg1Of activation,Tat
R12323 T15373 T15372 arg1Of activation,transcriptional
R12324 T15373 T15374 arg1Of activation,was
R12325 T15373 T15375 arg2Of activation,mediated
R12326 T15375 T15368 arg2Of mediated,indicating
R12327 T15375 T15369 arg1Of mediated,that
R12328 T15375 T15374 arg2Of mediated,was
R12329 T15377 T15375 arg1Of p65,mediated
R12330 T15377 T15376 arg2Of p65,by
R12331 T15377 T15378 arg1Of p65,(
R12332 T15380 T15378 arg2Of 5A–E,(
R12333 T15380 T15379 arg1Of 5A–E,Figure
R12334 T15381 T15378 arg3Of ),(
R12335 T15385 T15384 arg1Of expression,the
R12336 T15385 T15386 arg1Of expression,of
R12337 T15385 T15393 arg1Of expression,was
R12338 T15385 T15394 arg2Of expression,unaffected
R12339 T15389 T15387 arg1Of genes,the
R12340 T15389 T15388 arg1Of genes,NF-κB-independent
R12341 T15390 T15391 arg1Of GAPDH,and
R12342 T15391 T15386 arg2Of and,of
R12343 T15391 T15389 arg1Of and,genes
R12344 T15392 T15391 arg2Of ACTB,and
R12345 T15394 T15382 arg1Of unaffected,Differently
R12346 T15394 T15383 arg1Of unaffected,","
R12347 T15394 T15393 arg2Of unaffected,was
R12348 T15394 T15395 arg1Of unaffected,by
R12349 T15396 T15397 arg1Of wild-type,and
R12350 T15397 T15395 arg2Of and,by
R12351 T15397 T15400 arg1Of and,(
R12352 T15399 T15397 arg2Of mutants,and
R12353 T15399 T15398 arg1Of mutants,Tat
R12354 T15402 T15401 arg1Of 5F,Figure
R12355 T15402 T15403 arg1Of 5F,and
R12356 T15403 T15400 arg2Of and,(
R12357 T15404 T15403 arg2Of G,and
R12358 T15405 T15400 arg3Of ),(
R12359 T15407 T15406 arg1Of results,These
R12360 T15407 T15408 arg1Of results,were
R12361 T15407 T15409 arg1Of results,consistent
R12362 T15409 T15408 arg2Of consistent,were
R12363 T15409 T15410 arg1Of consistent,with
R12364 T15412 T15410 arg2Of requirement,with
R12365 T15412 T15411 arg1Of requirement,the
R12366 T15412 T15413 arg1Of requirement,of
R12367 T15416 T15417 arg1Of cysteine-rich,and
R12368 T15418 T15417 arg2Of arginine-rich,and
R12369 T15419 T15413 arg2Of domains,of
R12370 T15419 T15414 arg1Of domains,both
R12371 T15419 T15415 arg1Of domains,the
R12372 T15419 T15416 arg1Of domains,cysteine-rich
R12373 T15419 T15418 arg1Of domains,arginine-rich
R12374 T15419 T15420 arg1Of domains,of
R12375 T15421 T15420 arg2Of Tat,of
R12376 T15421 T15422 modOf Tat,to
R12377 T15423 T15422 arg1Of enhance,to
R12378 T15423 T15427 arg1Of enhance,","
R12379 T15423 T15428 modOf enhance,suggesting
R12380 T15426 T15423 arg2Of activity,enhance
R12381 T15426 T15424 arg1Of activity,the
R12382 T15426 T15425 arg1Of activity,NF-κB
R12383 T15431 T15430 arg1Of up-regulation,the
R12384 T15431 T15432 arg1Of up-regulation,of
R12385 T15431 T15435 arg1Of up-regulation,by
R12386 T15431 T15437 arg1Of up-regulation,might
R12387 T15431 T15438 arg1Of up-regulation,occur
R12388 T15434 T15432 arg2Of genes,of
R12389 T15434 T15433 arg1Of genes,NF-κB-responsive
R12390 T15436 T15435 arg2Of Tat,by
R12391 T15438 T15428 arg2Of occur,suggesting
R12392 T15438 T15429 arg1Of occur,that
R12393 T15438 T15437 arg2Of occur,might
R12394 T15438 T15439 arg1Of occur,through
R12395 T15441 T15439 arg2Of interaction,through
R12396 T15441 T15440 arg1Of interaction,physical
R12397 T15441 T15442 arg1Of interaction,of
R12398 T15441 T15446 arg1Of interaction,with
R12399 T15445 T15442 arg2Of protein,of
R12400 T15445 T15443 arg1Of protein,the
R12401 T15445 T15444 arg1Of protein,viral
R12402 T15447 T15448 arg1Of p65,and
R12403 T15448 T15446 arg2Of and,with
R12404 T15449 T15448 arg2Of IκB-α,and
R12405 T15450 T15451 arg1Of MIP-1α,","
R12406 T15450 T15452 arg1Of MIP-1α,which
R12407 T15450 T15453 arg1Of MIP-1α,was
R12408 T15450 T15461 arg1Of MIP-1α,encodes
R12409 T15456 T15455 arg1Of activated,mostly
R12410 T15457 T15453 arg2Of gene,was
R12411 T15457 T15454 arg1Of gene,the
R12412 T15457 T15456 arg1Of gene,activated
R12413 T15457 T15458 arg1Of gene,by
R12414 T15459 T15458 arg2Of Tat,by
R12415 T15461 T15460 arg1Of encodes,","
R12416 T15461 T15462 arg1Of encodes,for
R12417 T15464 T15462 arg2Of chemokine,for
R12418 T15464 T15463 arg1Of chemokine,a
R12419 T15464 T15465 arg1Of chemokine,that
R12420 T15464 T15466 arg1Of chemokine,promotes
R12421 T15468 T15466 arg2Of recruitment,promotes
R12422 T15468 T15467 arg1Of recruitment,the
R12423 T15468 T15469 arg1Of recruitment,of
R12424 T15471 T15469 arg2Of cells,of
R12425 T15471 T15470 arg1Of cells,pro-inflammatory
R12426 T15471 T15472 arg1Of cells,(
R12427 T15473 T15472 arg2Of 56,(
R12428 T15474 T15472 arg3Of ),(
R12429 T15478 T15476 arg2Of findings,with
R12430 T15478 T15477 arg1Of findings,our
R12431 T15481 T15480 arg1Of expression,MIP-1α
R12432 T15481 T15482 arg1Of expression,was
R12433 T15481 T15483 arg2Of expression,increased
R12434 T15483 T15475 arg1Of increased,Consistently
R12435 T15483 T15476 arg1Of increased,with
R12436 T15483 T15479 arg1Of increased,","
R12437 T15483 T15482 arg2Of increased,was
R12438 T15483 T15484 arg1Of increased,in
R12439 T15483 T15496 arg1Of increased,;
R12440 T15486 T15485 arg1Of cells,glial
R12441 T15486 T15487 arg1Of cells,and
R12442 T15487 T15484 arg2Of and,in
R12443 T15489 T15487 arg2Of nodes,and
R12444 T15489 T15488 arg1Of nodes,lymph
R12445 T15489 T15490 arg1Of nodes,of
R12446 T15492 T15490 arg2Of patients,of
R12447 T15492 T15491 arg1Of patients,AIDS
R12448 T15492 T15493 arg1Of patients,(
R12449 T15494 T15493 arg2Of "57,58",(
R12450 T15495 T15493 arg3Of ),(
R12451 T15500 T15499 arg1Of production,MIP-1α
R12452 T15500 T15501 arg1Of production,was
R12453 T15500 T15502 arg2Of production,induced
R12454 T15502 T15496 arg2Of induced,;
R12455 T15502 T15497 arg1Of induced,moreover
R12456 T15502 T15498 arg1Of induced,","
R12457 T15502 T15501 arg2Of induced,was
R12458 T15505 T15504 arg1Of infection,HIV-1
R12459 T15505 T15506 arg1Of infection,(
R12460 T15505 T15509 arg1Of infection,and
R12461 T15507 T15506 arg2Of "59,60",(
R12462 T15508 T15506 arg3Of ),(
R12463 T15509 T15502 arg1Of and,induced
R12464 T15509 T15503 arg2Of and,by
R12465 T15511 T15509 arg2Of protein,and
R12466 T15511 T15510 arg1Of protein,Tat
R12467 T15511 T15512 arg1Of protein,(
R12468 T15513 T15512 arg2Of "57,61,62",(
R12469 T15514 T15512 arg3Of ),(
R12470 T15517 T15515 arg1Of regulation,The
R12471 T15517 T15516 arg1Of regulation,transcriptional
R12472 T15517 T15518 arg1Of regulation,of
R12473 T15517 T15520 arg1Of regulation,has
R12474 T15517 T15521 arg1Of regulation,been
R12475 T15517 T15523 arg2Of regulation,characterized
R12476 T15519 T15518 arg2Of MIP-1α,of
R12477 T15523 T15520 arg2Of characterized,has
R12478 T15523 T15521 arg2Of characterized,been
R12479 T15523 T15522 arg1Of characterized,poorly
R12480 T15525 T15524 arg1Of analysis,Jaspar-based
R12481 T15525 T15526 arg1Of analysis,(
R12482 T15525 T15531 arg1Of analysis,predicted
R12483 T15527 T15526 arg2Of http,(
R12484 T15528 T15526 arg3Of :,(
R12485 T15529 T15530 arg1Of //jaspar.genereg.net/,)
R12486 T15531 T15529 arg1Of predicted,//jaspar.genereg.net/
R12487 T15535 T15531 arg2Of enhancers,predicted
R12488 T15535 T15532 arg1Of enhancers,three
R12489 T15535 T15533 arg1Of enhancers,putative
R12490 T15535 T15534 arg1Of enhancers,NF-κB
R12491 T15535 T15536 arg1Of enhancers,in
R12492 T15535 T15545 arg1Of enhancers,:
R12493 T15540 T15536 arg2Of region,in
R12494 T15540 T15537 arg1Of region,the
R12495 T15540 T15538 arg1Of region,proximal
R12496 T15540 T15539 arg1Of region,promoter
R12497 T15540 T15541 arg1Of region,of
R12498 T15544 T15541 arg2Of gene,of
R12499 T15544 T15542 arg1Of gene,the
R12500 T15544 T15543 arg1Of gene,MIP-1α
R12501 T15546 T15545 arg2Of NF-κB1,:
R12502 T15546 T15547 arg1Of NF-κB1,","
R12503 T15546 T15550 arg1Of NF-κB1,;
R12504 T15549 T15547 arg2Of nucleotides,","
R12505 T15549 T15548 arg1Of nucleotides,−1023/−1014
R12506 T15551 T15550 arg2Of NF-κB2,;
R12507 T15551 T15552 arg1Of NF-κB2,","
R12508 T15551 T15555 arg1Of NF-κB2,;
R12509 T15554 T15552 arg2Of nucleotides,","
R12510 T15554 T15553 arg1Of nucleotides,−661/−652
R12511 T15556 T15555 arg2Of NF-κB3,;
R12512 T15556 T15557 arg1Of NF-κB3,","
R12513 T15559 T15557 arg2Of nucleotides,","
R12514 T15559 T15558 arg1Of nucleotides,+370/+379
R12515 T15559 T15560 arg1Of nucleotides,(
R12516 T15563 T15560 arg2Of S3A,(
R12517 T15563 T15561 arg1Of S3A,Supplementary
R12518 T15563 T15562 arg1Of S3A,Figure
R12519 T15564 T15560 arg3Of ),(
R12520 T15566 T15565 arg1Of validate,To
R12521 T15571 T15566 arg2Of sites,validate
R12522 T15571 T15567 arg1Of sites,the
R12523 T15571 T15568 arg2Of sites,predicted
R12524 T15571 T15569 arg1Of sites,NF-κB
R12525 T15571 T15570 arg1Of sites,binding
R12526 T15571 T15572 arg1Of sites,of
R12527 T15575 T15572 arg2Of promoter,of
R12528 T15575 T15573 arg1Of promoter,the
R12529 T15575 T15574 arg1Of promoter,MIP-1α
R12530 T15577 T15566 arg1Of we,validate
R12531 T15577 T15578 arg1Of we,stimulated
R12532 T15577 T15590 arg1Of we,measured
R12533 T15578 T15581 arg1Of stimulated,with
R12534 T15578 T15589 arg1Of stimulated,and
R12535 T15580 T15578 arg2Of cells,stimulated
R12536 T15580 T15579 arg1Of cells,HeLa
R12537 T15582 T15581 arg2Of TNF-α,with
R12538 T15582 T15583 arg1Of TNF-α,","
R12539 T15587 T15583 arg2Of inducer,","
R12540 T15587 T15584 arg1Of inducer,a
R12541 T15587 T15585 arg1Of inducer,well-known
R12542 T15587 T15586 arg1Of inducer,NF-κB
R12543 T15589 T15565 modOf and,To
R12544 T15589 T15576 arg1Of and,","
R12545 T15589 T15588 arg1Of and,","
R12546 T15590 T15589 arg2Of measured,and
R12547 T15593 T15591 arg1Of levels,the
R12548 T15593 T15592 arg1Of levels,expression
R12549 T15593 T15594 arg1Of levels,of
R12550 T15593 T15600 arg1Of levels,and
R12551 T15595 T15594 arg2Of MIP-1α,of
R12552 T15595 T15596 arg1Of MIP-1α,by
R12553 T15598 T15596 arg2Of PCR,by
R12554 T15598 T15597 arg1Of PCR,real-time
R12555 T15600 T15590 arg2Of and,measured
R12556 T15600 T15599 arg1Of and,","
R12557 T15603 T15600 arg2Of occupancy,and
R12558 T15603 T15601 arg1Of occupancy,the
R12559 T15603 T15602 arg1Of occupancy,p65
R12560 T15603 T15604 arg1Of occupancy,of
R12561 T15603 T15608 arg1Of occupancy,by
R12562 T15607 T15604 arg2Of sites,of
R12563 T15607 T15605 arg1Of sites,the
R12564 T15607 T15606 arg1Of sites,NF-κB
R12565 T15609 T15608 arg2Of ChIP,by
R12566 T15610 T15611 arg1Of TNF-α,activated
R12567 T15610 T15617 arg1Of TNF-α,induced
R12568 T15610 T15628 arg1Of TNF-α,affecting
R12569 T15611 T15616 arg1Of activated,and
R12570 T15613 T15611 arg2Of expression,activated
R12571 T15613 T15612 arg1Of expression,the
R12572 T15613 T15614 arg1Of expression,of
R12573 T15615 T15614 arg2Of MIP-1α,of
R12574 T15617 T15616 arg2Of induced,and
R12575 T15617 T15627 arg1Of induced,without
R12576 T15620 T15617 arg2Of recruitment,induced
R12577 T15620 T15618 arg1Of recruitment,the
R12578 T15620 T15619 arg1Of recruitment,p65
R12579 T15620 T15621 arg1Of recruitment,to
R12580 T15624 T15621 arg2Of site,to
R12581 T15624 T15622 arg1Of site,the
R12582 T15624 T15623 arg1Of site,NF-κB1
R12583 T15624 T15625 arg1Of site,of
R12584 T15626 T15625 arg2Of MIP-1α,of
R12585 T15628 T15627 arg2Of affecting,without
R12586 T15630 T15628 arg2Of occupancy,affecting
R12587 T15630 T15629 arg1Of occupancy,the
R12588 T15630 T15631 arg1Of occupancy,of
R12589 T15634 T15635 arg1Of NF-κB2,and
R12590 T15636 T15635 arg2Of NF-κB3,and
R12591 T15637 T15631 arg2Of sites,of
R12592 T15637 T15632 arg1Of sites,the
R12593 T15637 T15633 arg1Of sites,putative
R12594 T15637 T15634 arg1Of sites,NF-κB2
R12595 T15637 T15636 arg1Of sites,NF-κB3
R12596 T15637 T15638 arg1Of sites,(
R12597 T15641 T15639 arg1Of S3B,Supplementary
R12598 T15641 T15640 arg1Of S3B,Figure
R12599 T15641 T15642 arg1Of S3B,and
R12600 T15642 T15638 arg2Of and,(
R12601 T15643 T15642 arg2Of S3C,and
R12602 T15644 T15638 arg3Of ),(
R12603 T15645 T15647 arg1Of Tat,promoted
R12604 T15647 T15646 arg1Of promoted,also
R12605 T15647 T15658 arg1Of promoted,","
R12606 T15647 T15659 arg1Of promoted,while
R12607 T15649 T15647 arg2Of recruitment,promoted
R12608 T15649 T15648 arg1Of recruitment,the
R12609 T15649 T15650 arg1Of recruitment,of
R12610 T15649 T15652 arg1Of recruitment,to
R12611 T15651 T15650 arg2Of p65,of
R12612 T15655 T15652 arg2Of site,to
R12613 T15655 T15653 arg1Of site,the
R12614 T15655 T15654 arg1Of site,NF-κB1
R12615 T15655 T15656 arg1Of site,of
R12616 T15657 T15656 arg2Of MIP-1α,of
R12617 T15660 T15661 arg1Of it,did
R12618 T15660 T15663 arg1Of it,affect
R12619 T15663 T15659 arg2Of affect,while
R12620 T15663 T15661 arg2Of affect,did
R12621 T15663 T15662 arg1Of affect,not
R12622 T15666 T15667 arg1Of NF-κB2,and
R12623 T15668 T15667 arg2Of NF-κB3,and
R12624 T15669 T15663 arg2Of sites,affect
R12625 T15669 T15664 arg1Of sites,the
R12626 T15669 T15665 arg1Of sites,putative
R12627 T15669 T15666 arg1Of sites,NF-κB2
R12628 T15669 T15668 arg1Of sites,NF-κB3
R12629 T15669 T15670 arg1Of sites,(
R12630 T15673 T15670 arg2Of S3D,(
R12631 T15673 T15671 arg1Of S3D,Supplementary
R12632 T15673 T15672 arg1Of S3D,Figure
R12633 T15674 T15670 arg3Of ),(
R12634 T15677 T15676 arg1Of results,these
R12635 T15677 T15678 arg1Of results,indicated
R12636 T15678 T15675 arg1Of indicated,Altogether
R12637 T15682 T15680 arg1Of site,the
R12638 T15682 T15681 arg1Of site,NF-κB1
R12639 T15682 T15683 arg1Of site,was
R12640 T15683 T15678 arg2Of was,indicated
R12641 T15683 T15679 arg1Of was,that
R12642 T15683 T15693 arg1Of was,in
R12643 T15688 T15683 arg2Of enhancer,was
R12644 T15688 T15684 arg1Of enhancer,the
R12645 T15688 T15685 arg1Of enhancer,only
R12646 T15688 T15686 arg1Of enhancer,effective
R12647 T15688 T15687 arg1Of enhancer,NF-κB
R12648 T15688 T15689 arg1Of enhancer,of
R12649 T15692 T15689 arg2Of promoter,of
R12650 T15692 T15690 arg1Of promoter,the
R12651 T15692 T15691 arg1Of promoter,MIP-1α
R12652 T15694 T15693 arg2Of response,in
R12653 T15694 T15695 arg1Of response,to
R12654 T15696 T15697 arg1Of TNF-α,and
R12655 T15697 T15695 arg2Of and,to
R12656 T15698 T15697 arg2Of Tat,and
R12657 T15699 T15700 arg1Of Similarly,to
R12658 T15701 T15700 arg2Of MIP-1α,to
R12659 T15703 T15704 arg1Of Tat,increased
R12660 T15704 T15699 arg1Of increased,Similarly
R12661 T15704 T15702 arg1Of increased,","
R12662 T15704 T15721 arg1Of increased,","
R12663 T15704 T15722 arg1Of increased,while
R12664 T15706 T15704 arg2Of recruitment,increased
R12665 T15706 T15705 arg1Of recruitment,the
R12666 T15706 T15707 arg1Of recruitment,of
R12667 T15706 T15709 arg1Of recruitment,to
R12668 T15706 T15713 arg1Of recruitment,of
R12669 T15708 T15707 arg2Of p65,of
R12670 T15712 T15709 arg2Of enhancers,to
R12671 T15712 T15710 arg1Of enhancers,the
R12672 T15712 T15711 arg1Of enhancers,NF-κB
R12673 T15714 T15715 arg1Of CSF3,","
R12674 T15715 T15717 arg1Of ",",","
R12675 T15716 T15715 arg2Of LTA,","
R12676 T15717 T15719 arg1Of ",",and
R12677 T15718 T15717 arg2Of NFKBIA,","
R12678 T15719 T15713 arg2Of and,of
R12679 T15720 T15719 arg2Of TLR2,and
R12680 T15723 T15724 arg1Of it,was
R12681 T15723 T15725 arg1Of it,ineffective
R12682 T15724 T15722 arg2Of was,while
R12683 T15724 T15726 arg1Of was,at
R12684 T15725 T15724 arg2Of ineffective,was
R12685 T15728 T15726 arg2Of promoters,at
R12686 T15728 T15727 arg1Of promoters,the
R12687 T15728 T15729 arg1Of promoters,of
R12688 T15730 T15731 arg1Of GAPDH,and
R12689 T15731 T15729 arg2Of and,of
R12690 T15731 T15733 arg1Of and,(
R12691 T15732 T15731 arg2Of ACTB,and
R12692 T15735 T15733 arg2Of 5H,(
R12693 T15735 T15734 arg1Of 5H,Figure
R12694 T15736 T15733 arg3Of ),(
R12695 T15738 T15737 arg2Of ChIP,By
R12696 T15740 T15741 arg1Of Tat,bound
R12697 T15741 T15737 arg1Of bound,By
R12698 T15741 T15739 arg1Of bound,","
R12699 T15741 T15742 arg1Of bound,to
R12700 T15741 T15749 arg1Of bound,to
R12701 T15741 T15755 arg1Of bound,","
R12702 T15741 T15756 arg1Of bound,with
R12703 T15741 T15768 arg1Of bound,","
R12704 T15741 T15769 modOf bound,suggesting
R12705 T15742 T15747 arg1Of to,and
R12706 T15745 T15742 arg2Of promoters,to
R12707 T15745 T15743 arg1Of promoters,the
R12708 T15745 T15744 arg1Of promoters,NF-κB-responsive
R12709 T15747 T15746 arg1Of and,","
R12710 T15749 T15747 arg2Of to,and
R12711 T15749 T15748 arg1Of to,not
R12712 T15751 T15752 arg1Of GAPDH,and
R12713 T15753 T15752 arg2Of ACTB,and
R12714 T15754 T15749 arg2Of promoters,to
R12715 T15754 T15750 arg1Of promoters,the
R12716 T15754 T15751 arg1Of promoters,GAPDH
R12717 T15754 T15753 arg1Of promoters,ACTB
R12718 T15757 T15756 arg2Of loss,with
R12719 T15757 T15758 arg1Of loss,of
R12720 T15757 T15760 arg1Of loss,following
R12721 T15759 T15758 arg2Of binding,of
R12722 T15763 T15760 arg2Of interference,following
R12723 T15763 T15761 arg1Of interference,p65
R12724 T15763 T15762 arg1Of interference,RNA
R12725 T15763 T15764 arg1Of interference,(
R12726 T15766 T15764 arg2Of 5I,(
R12727 T15766 T15765 arg1Of 5I,Figure
R12728 T15767 T15764 arg3Of ),(
R12729 T15772 T15771 arg1Of occupancy,Tat
R12730 T15772 T15773 arg1Of occupancy,occurred
R12731 T15773 T15769 arg2Of occurred,suggesting
R12732 T15773 T15770 arg1Of occurred,that
R12733 T15773 T15774 arg1Of occurred,via
R12734 T15776 T15774 arg2Of interaction,via
R12735 T15776 T15775 arg1Of interaction,p65
R12736 T15779 T15777 arg2Of findings,As
R12737 T15779 T15778 arg1Of findings,additional
R12738 T15781 T15782 arg1Of IκB-α,was
R12739 T15781 T15783 arg1Of IκB-α,chromatin-immunoprecipitated
R12740 T15782 T15784 arg1Of was,at
R12741 T15782 T15788 arg1Of was,in
R12742 T15782 T15793 arg1Of was,and
R12743 T15783 T15782 arg2Of chromatin-immunoprecipitated,was
R12744 T15787 T15784 arg2Of enhancers,at
R12745 T15787 T15785 arg1Of enhancers,the
R12746 T15787 T15786 arg1Of enhancers,NF-κB
R12747 T15788 T15790 arg1Of in,of
R12748 T15789 T15788 arg2Of absence,in
R12749 T15791 T15788 arg3Of Tat,in
R12750 T15793 T15777 arg1Of and,As
R12751 T15793 T15780 arg1Of and,","
R12752 T15793 T15792 arg1Of and,","
R12753 T15794 T15795 arg1Of it,was
R12754 T15794 T15797 arg2Of it,removed
R12755 T15797 T15793 arg2Of removed,and
R12756 T15797 T15795 arg2Of removed,was
R12757 T15797 T15796 arg1Of removed,significantly
R12758 T15797 T15798 arg1Of removed,in
R12759 T15797 T15812 arg1Of removed,","
R12760 T15797 T15813 modOf removed,indicating
R12761 T15798 T15800 arg1Of in,of
R12762 T15799 T15798 arg2Of presence,in
R12763 T15801 T15803 arg1Of Tat,or
R12764 T15803 T15798 arg3Of or,in
R12765 T15803 T15802 arg1Of or,","
R12766 T15804 T15803 arg2Of following,or
R12767 T15807 T15804 arg2Of interference,following
R12768 T15807 T15805 arg1Of interference,IκB-α
R12769 T15807 T15806 arg1Of interference,RNA
R12770 T15807 T15808 arg1Of interference,(
R12771 T15810 T15808 arg2Of 5J,(
R12772 T15810 T15809 arg1Of 5J,Figure
R12773 T15811 T15808 arg3Of ),(
R12774 T15815 T15816 arg1Of Tat,displaced
R12775 T15815 T15817 arg1Of Tat,IκB-α
R12776 T15816 T15813 arg2Of displaced,indicating
R12777 T15816 T15814 arg1Of displaced,that
R12778 T15817 T15816 arg2Of IκB-α,displaced
R12779 T15817 T15818 arg1Of IκB-α,from
R12780 T15819 T15818 arg2Of promoters,from
R14250 T17797 T17795 arg2Of monocytes,In
R14251 T17797 T17796 arg1Of monocytes,HIV-1-infected
R14252 T17798 T17799 arg1Of Tat,sustains
R14253 T17798 T17804 arg1Of Tat,promotes
R14254 T17798 T17811 arg1Of Tat,interacting
R14255 T17799 T17803 arg1Of sustains,and
R14256 T17802 T17799 arg2Of activity,sustains
R14257 T17802 T17800 arg1Of activity,the
R14258 T17802 T17801 arg1Of activity,NF-κB
R14259 T17803 T17795 arg1Of and,In
R14260 T17803 T17810 arg1Of and,by
R14261 T17804 T17803 arg2Of promotes,and
R14262 T17807 T17804 arg2Of activation,promotes
R14263 T17807 T17805 arg1Of activation,the
R14264 T17807 T17806 arg1Of activation,transcriptional
R14265 T17807 T17808 arg1Of activation,of
R14266 T17809 T17808 arg2Of MIP-1α,of
R14267 T17811 T17810 arg2Of interacting,by
R14268 T17811 T17812 arg1Of interacting,with
R14269 T17813 T17814 arg1Of IκB-α,and
R14270 T17814 T17812 arg2Of and,with
R14271 T17815 T17814 arg2Of p65,and
R14272 T17816 T17818 arg2Of We,analysed
R14273 T17818 T17817 arg1Of analysed,next
R14274 T17820 T17821 arg1Of Tat,affected
R14275 T17821 T17818 arg1Of affected,analysed
R14276 T17821 T17819 arg1Of affected,whether
R14277 T17821 T17830 arg1Of affected,in
R14278 T17824 T17822 arg1Of activity,the
R14279 T17824 T17823 arg1Of activity,NF-κB
R14280 T17824 T17825 arg1Of activity,and
R14281 T17825 T17821 arg2Of and,affected
R14282 T17827 T17825 arg2Of expression,and
R14283 T17827 T17826 arg1Of expression,the
R14284 T17827 T17828 arg1Of expression,of
R14285 T17829 T17828 arg2Of MIP-1α,of
R14286 T17832 T17830 arg2Of course,in
R14287 T17832 T17831 arg1Of course,the
R14288 T17832 T17833 arg1Of course,of
R14289 T17835 T17833 arg2Of infection,of
R14290 T17835 T17834 arg1Of infection,HIV-1
R14291 T17837 T17836 arg1Of detect,To
R14292 T17840 T17837 arg2Of protein,detect
R14293 T17840 T17838 arg1Of protein,the
R14294 T17840 T17839 arg1Of protein,Tat
R14295 T17842 T17837 arg1Of we,detect
R14296 T17842 T17843 arg1Of we,produced
R14297 T17843 T17836 modOf produced,To
R14298 T17843 T17841 arg1Of produced,","
R14299 T17847 T17843 arg2Of virions,produced
R14300 T17847 T17844 arg1Of virions,HXB2
R14301 T17847 T17845 arg1Of virions,Env-pseudotyped
R14302 T17847 T17846 arg1Of virions,NL4-3.FLAG-Tat.R−E−
R14303 T17847 T17848 arg1Of virions,","
R14304 T17847 T17849 arg1Of virions,which
R14305 T17847 T17850 arg1Of virions,were
R14306 T17847 T17851 arg2Of virions,used
R14307 T17851 T17850 arg2Of used,were
R14308 T17851 T17852 arg1Of used,in
R14309 T17854 T17852 arg2Of infection,in
R14310 T17854 T17853 arg1Of infection,single-round
R14311 T17854 T17855 arg1Of infection,of
R14312 T17856 T17855 arg2Of U937,of
R14313 T17856 T17857 arg1Of U937,","
R14314 T17862 T17857 arg2Of line,","
R14315 T17862 T17858 arg1Of line,a
R14316 T17862 T17859 arg1Of line,human
R14317 T17862 T17860 arg1Of line,monocytic
R14318 T17862 T17861 arg1Of line,cell
R14319 T17863 T17864 arg1Of Cells,were
R14320 T17863 T17865 arg2Of Cells,transfected
R14321 T17863 T17873 arg1Of Cells,left
R14322 T17863 T17876 arg1Of Cells,modulate
R14323 T17863 T17883 arg2Of Cells,analysed
R14324 T17865 T17866 arg1Of transfected,with
R14325 T17865 T17872 arg1Of transfected,or
R14326 T17868 T17867 arg1Of Tat,siRNA
R14327 T17868 T17869 arg1Of Tat,","
R14328 T17869 T17866 arg2Of ",",with
R14329 T17871 T17869 arg2Of control,","
R14330 T17871 T17870 arg1Of control,siRNA
R14331 T17872 T17881 arg1Of or,and
R14332 T17873 T17872 arg2Of left,or
R14333 T17874 T17873 arg2Of untransfected,left
R14334 T17876 T17873 arg3Of modulate,left
R14335 T17876 T17875 arg1Of modulate,to
R14336 T17879 T17876 arg2Of expression,modulate
R14337 T17879 T17877 arg1Of expression,the
R14338 T17879 T17878 arg1Of expression,Tat
R14339 T17881 T17864 arg2Of and,were
R14340 T17881 T17880 arg1Of and,","
R14341 T17883 T17881 arg2Of analysed,and
R14342 T17883 T17882 arg1Of analysed,then
R14343 T17883 T17884 arg1Of analysed,for
R14344 T17886 T17884 arg2Of kinetic,for
R14345 T17886 T17885 arg1Of kinetic,the
R14346 T17886 T17887 arg1Of kinetic,of
R14347 T17889 T17887 arg2Of activation,of
R14348 T17889 T17888 arg1Of activation,NF-κB
R14349 T17889 T17890 arg1Of activation,following
R14350 T17892 T17890 arg2Of infection,following
R14351 T17892 T17891 arg1Of infection,viral
R14352 T17894 T17893 arg1Of expression,The
R14353 T17894 T17895 arg1Of expression,of
R14354 T17894 T17899 arg1Of expression,was
R14355 T17894 T17900 arg2Of expression,detected
R14356 T17896 T17897 arg1Of Tat,and
R14357 T17897 T17895 arg2Of and,of
R14358 T17898 T17897 arg2Of p24,and
R14359 T17900 T17899 arg2Of detected,was
R14360 T17900 T17901 arg1Of detected,at
R14361 T17900 T17903 arg1Of detected,to
R14362 T17900 T17906 arg1Of detected,","
R14363 T17900 T17907 arg1Of detected,while
R14364 T17902 T17901 arg2Of 3-,at
R14365 T17905 T17903 arg2Of post-infection,to
R14366 T17905 T17904 arg1Of post-infection,12-h
R14367 T17908 T17909 arg1Of it,was
R14368 T17908 T17911 arg2Of it,detected
R14369 T17911 T17907 arg2Of detected,while
R14370 T17911 T17909 arg2Of detected,was
R14371 T17911 T17910 arg1Of detected,barely
R14372 T17911 T17912 arg1Of detected,in
R14373 T17915 T17912 arg2Of cells,in
R14374 T17915 T17913 arg1Of cells,siRNA
R14375 T17915 T17914 arg1Of cells,Tat-transfected
R14376 T17915 T17916 arg1Of cells,(
R14377 T17918 T17916 arg2Of 6A,(
R14378 T17918 T17917 arg1Of 6A,Figure
R14379 T17919 T17916 arg3Of ),(
R14380 T17922 T17920 arg1Of activity,The
R14381 T17922 T17921 arg1Of activity,NF-κB
R14382 T17922 T17931 arg1Of activity,was
R14383 T17922 T17932 arg2Of activity,induced
R14384 T17922 T17955 arg1Of activity,increased
R14385 T17925 T17924 arg2Of measured,as
R14386 T17925 T17926 arg1Of measured,by
R14387 T17929 T17926 arg2Of binding,by
R14388 T17929 T17927 arg1Of binding,p65
R14389 T17929 T17928 arg1Of binding,DNA
R14390 T17932 T17931 arg2Of induced,was
R14391 T17932 T17933 arg1Of induced,at
R14392 T17932 T17936 arg1Of induced,in
R14393 T17932 T17954 arg1Of induced,and
R14394 T17935 T17933 arg2Of post-infection,at
R14395 T17935 T17934 arg1Of post-infection,3-h
R14396 T17938 T17937 arg1Of Tat-positive,both
R14397 T17938 T17939 arg1Of Tat-positive,(
R14398 T17938 T17946 arg1Of Tat-positive,and
R14399 T17941 T17942 arg1Of siRNA,and
R14400 T17942 T17939 arg2Of and,(
R14401 T17942 T17940 arg1Of and,no
R14402 T17944 T17942 arg2Of control,and
R14403 T17944 T17943 arg1Of control,siRNA
R14404 T17945 T17939 arg3Of ),(
R14405 T17946 T17936 arg2Of and,in
R14406 T17948 T17946 arg2Of cells,and
R14407 T17948 T17947 arg1Of cells,Tat-negative
R14408 T17948 T17949 arg1Of cells,(
R14409 T17951 T17949 arg2Of Tat,(
R14410 T17951 T17950 arg1Of Tat,siRNA
R14411 T17952 T17949 arg3Of ),(
R14412 T17954 T17923 arg1Of and,","
R14413 T17954 T17924 arg1Of and,as
R14414 T17954 T17930 arg1Of and,","
R14415 T17954 T17953 arg1Of and,","
R14416 T17955 T17954 arg2Of increased,and
R14417 T17955 T17956 arg1Of increased,at
R14418 T17955 T17959 arg1Of increased,in
R14419 T17957 T17956 arg2Of 12 h,at
R14420 T17959 T17958 arg1Of in,only
R14421 T17961 T17959 arg2Of cells,in
R14422 T17961 T17960 arg1Of cells,Tat-positive
R14423 T17961 T17962 arg1Of cells,(
R14424 T17964 T17962 arg2Of 6B,(
R14425 T17964 T17963 arg1Of 6B,Figure
R14426 T17965 T17962 arg3Of ),(
R14427 T17966 T17967 arg1Of Degradation,of
R14428 T17966 T17969 arg1Of Degradation,was
R14429 T17966 T17970 arg2Of Degradation,observed
R14430 T17966 T17976 arg1Of Degradation,was
R14431 T17966 T17977 arg2Of Degradation,followed
R14432 T17968 T17967 arg2Of IκB-α,of
R14433 T17970 T17969 arg2Of observed,was
R14434 T17970 T17971 arg1Of observed,at
R14435 T17970 T17975 arg1Of observed,and
R14436 T17973 T17971 arg2Of post-infection,at
R14437 T17973 T17972 arg1Of post-infection,3-h
R14438 T17975 T17974 arg1Of and,","
R14439 T17977 T17975 arg2Of followed,and
R14440 T17977 T17976 arg2Of followed,was
R14441 T17977 T17984 arg1Of followed,at
R14442 T17980 T17979 arg1Of novo,de
R14443 T17981 T17977 arg1Of synthesis,followed
R14444 T17981 T17978 arg2Of synthesis,by
R14445 T17981 T17980 arg1Of synthesis,novo
R14446 T17981 T17982 arg1Of synthesis,of
R14447 T17983 T17982 arg2Of IκB-α,of
R14448 T17985 T17984 arg2Of 12 h,at
R14449 T17985 T17986 arg1Of 12 h,independently
R14450 T17986 T17987 arg1Of independently,of
R14451 T17990 T17987 arg2Of presence,of
R14452 T17990 T17988 arg1Of presence,the
R14453 T17990 T17989 arg1Of presence,Tat
R14454 T17990 T17991 arg1Of presence,(
R14455 T17993 T17991 arg2Of 6C,(
R14456 T17993 T17992 arg1Of 6C,Figure
R14457 T17994 T17991 arg3Of ),(
R14458 T17999 T17997 arg1Of activity,the
R14459 T17999 T17998 arg1Of activity,IKK
R14460 T17999 T18000 arg1Of activity,was
R14461 T17999 T18001 arg2Of activity,induced
R14462 T17999 T18006 arg1Of activity,turned
R14463 T18001 T18000 arg2Of induced,was
R14464 T18001 T18002 arg1Of induced,at
R14465 T18001 T18005 arg1Of induced,and
R14466 T18004 T18002 arg2Of post-infection,at
R14467 T18004 T18003 arg1Of post-infection,3-h
R14468 T18005 T17995 arg1Of and,Consistently
R14469 T18005 T17996 arg1Of and,","
R14470 T18006 T18005 arg2Of turned,and
R14471 T18006 T18007 arg1Of turned,off
R14472 T18006 T18008 arg1Of turned,at
R14473 T18006 T18010 arg1Of turned,independently
R14474 T18009 T18008 arg2Of 12 h,at
R14475 T18010 T18011 arg1Of independently,of
R14476 T18014 T18011 arg2Of presence,of
R14477 T18014 T18012 arg1Of presence,the
R14478 T18014 T18013 arg1Of presence,Tat
R14479 T18014 T18015 arg1Of presence,(
R14480 T18017 T18015 arg2Of 6D,(
R14481 T18017 T18016 arg1Of 6D,Figure
R14482 T18018 T18015 arg3Of ),(
R14483 T18020 T18019 arg1Of results,These
R14484 T18020 T18021 arg1Of results,agreed
R14485 T18020 T18042 arg1Of results,supported
R14486 T18021 T18022 arg1Of agreed,with
R14487 T18021 T18040 arg1Of agreed,and
R14488 T18024 T18022 arg2Of kinetic,with
R14489 T18024 T18023 arg1Of kinetic,the
R14490 T18024 T18025 arg1Of kinetic,of
R14491 T18027 T18025 arg2Of activation,of
R14492 T18027 T18026 arg1Of activation,NF-κB
R14493 T18027 T18028 arg1Of activation,in
R14494 T18031 T18028 arg2Of infection,in
R14495 T18031 T18029 arg1Of infection,single-round
R14496 T18031 T18030 arg1Of infection,HIV-1
R14497 T18031 T18032 arg1Of infection,of
R14498 T18034 T18032 arg2Of cells,of
R14499 T18034 T18033 arg1Of cells,Jurkat
R14500 T18034 T18035 arg1Of cells,(
R14501 T18036 T18035 arg2Of Figure,(
R14502 T18036 T18037 arg1Of Figure,1
R14503 T18038 T18035 arg3Of ),(
R14504 T18040 T18039 arg1Of and,","
R14505 T18042 T18040 arg2Of supported,and
R14506 T18042 T18041 arg1Of supported,further
R14507 T18044 T18042 arg2Of requirement,supported
R14508 T18044 T18043 arg1Of requirement,the
R14509 T18044 T18045 arg1Of requirement,of
R14510 T18044 T18048 modOf requirement,to
R14511 T18047 T18045 arg2Of expression,of
R14512 T18047 T18046 arg1Of expression,viral
R14513 T18049 T18048 arg1Of counteract,to
R14514 T18049 T18053 arg1Of counteract,off
R14515 T18052 T18049 arg2Of turn,counteract
R14516 T18052 T18050 arg1Of turn,the
R14517 T18052 T18051 arg1Of turn,post-activation
R14518 T18053 T18054 arg1Of off,of
R14519 T18055 T18054 arg2Of NF-κB,of
R14520 T18059 T18056 arg2Of cells,In
R14521 T18059 T18057 arg1Of cells,HIV-1-infected
R14522 T18059 T18058 arg1Of cells,U937
R14523 T18063 T18061 arg1Of Tat,the
R14524 T18063 T18062 arg1Of Tat,endogenous
R14525 T18063 T18064 arg1Of Tat,was
R14526 T18063 T18065 arg2Of Tat,coimmunoprecipitated
R14527 T18063 T18076 arg1Of Tat,activated
R14528 T18065 T18064 arg2Of coimmunoprecipitated,was
R14529 T18065 T18066 arg1Of coimmunoprecipitated,with
R14530 T18065 T18075 arg1Of coimmunoprecipitated,and
R14531 T18067 T18068 arg1Of IκB-α,and
R14532 T18068 T18066 arg2Of and,with
R14533 T18069 T18068 arg2Of p65,and
R14534 T18069 T18070 arg1Of p65,(
R14535 T18072 T18070 arg2Of 6E,(
R14536 T18072 T18071 arg1Of 6E,Figure
R14537 T18073 T18070 arg3Of ),(
R14538 T18075 T18056 arg1Of and,In
R14539 T18075 T18060 arg1Of and,","
R14540 T18075 T18074 arg1Of and,","
R14541 T18076 T18075 arg2Of activated,and
R14542 T18076 T18080 arg1Of activated,in
R14543 T18076 T18084 arg1Of activated,","
R14544 T18076 T18085 arg1Of activated,as
R14545 T18079 T18076 arg2Of expression,activated
R14546 T18079 T18077 arg1Of expression,the
R14547 T18079 T18078 arg1Of expression,MIP-1α
R14548 T18083 T18080 arg2Of manner,in
R14549 T18083 T18081 arg1Of manner,a
R14550 T18083 T18082 arg1Of manner,p65-dependent
R14551 T18086 T18085 arg2Of shown,as
R14552 T18086 T18092 arg1Of shown,following
R14553 T18089 T18086 arg1Of lack,shown
R14554 T18089 T18087 arg2Of lack,by
R14555 T18089 T18088 arg1Of lack,the
R14556 T18089 T18090 arg1Of lack,of
R14557 T18091 T18090 arg2Of effect,of
R14558 T18094 T18093 arg1Of interference,RNA
R14559 T18094 T18095 arg1Of interference,of
R14560 T18094 T18097 arg1Of interference,or
R14561 T18096 T18095 arg2Of Tat,of
R14562 T18097 T18092 arg2Of or,following
R14563 T18098 T18097 arg2Of p65,or
R14564 T18098 T18099 arg1Of p65,(
R14565 T18101 T18099 arg2Of 6F,(
R14566 T18101 T18100 arg1Of 6F,Figure
R14567 T18102 T18099 arg3Of ),(
R14568 T18105 T18106 arg1Of Tat,and
R14569 T18106 T18108 arg1Of and,were
R14570 T18106 T18110 arg2Of and,recruited
R14571 T18107 T18106 arg2Of p65,and
R14572 T18110 T18103 arg1Of recruited,Moreover
R14573 T18110 T18104 arg1Of recruited,","
R14574 T18110 T18108 arg2Of recruited,were
R14575 T18110 T18109 arg1Of recruited,both
R14576 T18110 T18111 arg1Of recruited,to
R14577 T18110 T18117 arg1Of recruited,","
R14578 T18110 T18118 arg1Of recruited,while
R14579 T18114 T18111 arg2Of enhancer,to
R14580 T18114 T18112 arg1Of enhancer,the
R14581 T18114 T18113 arg1Of enhancer,NF-κB
R14582 T18114 T18115 arg1Of enhancer,of
R14583 T18116 T18115 arg2Of MIP-1α,of
R14584 T18121 T18119 arg1Of occupancy,the
R14585 T18121 T18120 arg1Of occupancy,p65
R14586 T18121 T18122 arg1Of occupancy,was
R14587 T18121 T18123 arg2Of occupancy,abolished
R14588 T18123 T18118 arg2Of abolished,while
R14589 T18123 T18122 arg2Of abolished,was
R14590 T18126 T18123 arg1Of Tat,abolished
R14591 T18126 T18124 arg2Of Tat,by
R14592 T18126 T18125 arg1Of Tat,siRNA
R14593 T18126 T18127 arg1Of Tat,(
R14594 T18129 T18128 arg1Of 6G,Figure
R14595 T18129 T18130 arg1Of 6G,and
R14596 T18130 T18127 arg2Of and,(
R14597 T18131 T18130 arg2Of H,and
R14598 T18132 T18127 arg3Of ),(
R14599 T18135 T18134 arg1Of results,these
R14600 T18135 T18136 arg1Of results,indicated
R14601 T18136 T18133 arg1Of indicated,Altogether
R14602 T18142 T18138 arg2Of infection,in
R14603 T18142 T18139 arg1Of infection,single
R14604 T18142 T18140 arg1Of infection,round
R14605 T18142 T18141 arg1Of infection,HIV-1
R14606 T18143 T18144 arg1Of Tat,associated
R14607 T18143 T18151 arg1Of Tat,induced
R14608 T18144 T18145 arg1Of associated,with
R14609 T18144 T18150 arg1Of associated,and
R14610 T18146 T18147 arg1Of IκB-α,and
R14611 T18147 T18145 arg2Of and,with
R14612 T18148 T18147 arg2Of p65,and
R14613 T18150 T18136 arg2Of and,indicated
R14614 T18150 T18137 arg1Of and,that
R14615 T18150 T18138 arg1Of and,in
R14616 T18150 T18149 arg1Of and,","
R14617 T18151 T18150 arg2Of induced,and
R14618 T18151 T18158 arg1Of induced,through
R14619 T18154 T18151 arg2Of activation,induced
R14620 T18154 T18152 arg1Of activation,the
R14621 T18154 T18153 arg1Of activation,p65-dependent
R14622 T18154 T18155 arg1Of activation,of
R14623 T18157 T18155 arg2Of expression,of
R14624 T18157 T18156 arg1Of expression,MIP-1α
R14625 T18159 T18160 arg1Of occupancy,of
R14626 T18159 T18164 arg1Of occupancy,and
R14627 T18163 T18160 arg2Of promoter,of
R14628 T18163 T18161 arg1Of promoter,the
R14629 T18163 T18162 arg1Of promoter,MIP-1α
R14630 T18164 T18158 arg2Of and,through
R14631 T18166 T18164 arg2Of recruitment,and
R14632 T18166 T18165 arg2Of recruitment,increased
R14633 T18166 T18167 arg1Of recruitment,of
R14634 T18168 T18167 arg2Of p65,of
R15863 T19912 T19911 arg1Of study,This
R15864 T19912 T19913 arg1Of study,reports
R15865 T19916 T19913 arg2Of mechanism,reports
R15866 T19916 T19914 arg1Of mechanism,a
R15867 T19916 T19915 arg1Of mechanism,novel
R15868 T19916 T19917 arg1Of mechanism,of
R15869 T19916 T19920 arg1Of mechanism,by
R15870 T19919 T19917 arg2Of activation,of
R15871 T19919 T19918 arg1Of activation,NF-κB
R15872 T19924 T19920 arg2Of transactivator,by
R15873 T19924 T19921 arg1Of transactivator,the
R15874 T19924 T19922 arg1Of transactivator,HIV-1
R15875 T19924 T19923 arg1Of transactivator,Tat
R15876 T19926 T19925 arg2Of on,Based
R15877 T19928 T19926 arg2Of evidence,on
R15878 T19928 T19927 arg1Of evidence,the
R15879 T19930 T19931 arg1Of Tat,enhanced
R15880 T19930 T19947 arg1Of Tat,interacted
R15881 T19931 T19945 arg1Of enhanced,and
R15882 T19934 T19931 arg2Of activity,enhanced
R15883 T19934 T19932 arg1Of activity,the
R15884 T19934 T19933 arg1Of activity,transcriptional
R15885 T19934 T19935 arg1Of activity,of
R15886 T19938 T19935 arg2Of subunit,of
R15887 T19938 T19936 arg1Of subunit,the
R15888 T19938 T19937 arg1Of subunit,p65
R15889 T19938 T19939 arg1Of subunit,of
R15890 T19940 T19939 arg2Of NF-κB,of
R15891 T19940 T19941 arg1Of NF-κB,(
R15892 T19942 T19941 arg2Of "49,63,64",(
R15893 T19943 T19941 arg3Of ),(
R15894 T19945 T19928 arg2Of and,evidence
R15895 T19945 T19929 arg1Of and,that
R15896 T19945 T19944 arg1Of and,","
R15897 T19947 T19945 arg2Of interacted,and
R15898 T19947 T19946 arg1Of interacted,physically
R15899 T19947 T19948 arg1Of interacted,with
R15900 T19951 T19948 arg2Of repressor,with
R15901 T19951 T19949 arg1Of repressor,the
R15902 T19951 T19950 arg1Of repressor,IκB-α
R15903 T19951 T19952 arg1Of repressor,(
R15904 T19953 T19952 arg2Of "50,51",(
R15905 T19954 T19952 arg3Of ),(
R15906 T19956 T19957 arg1Of we,investigated
R15907 T19957 T19925 arg1Of investigated,Based
R15908 T19957 T19955 arg1Of investigated,","
R15909 T19959 T19957 arg2Of possibility,investigated
R15910 T19959 T19958 arg1Of possibility,the
R15911 T19961 T19962 arg1Of Tat,could
R15912 T19961 T19963 arg1Of Tat,activate
R15913 T19963 T19959 arg2Of activate,possibility
R15914 T19963 T19960 arg1Of activate,that
R15915 T19963 T19962 arg2Of activate,could
R15916 T19963 T19965 arg1Of activate,via
R15917 T19964 T19963 arg2Of NF-κB,activate
R15918 T19967 T19965 arg2Of interaction,via
R15919 T19967 T19966 arg1Of interaction,direct
R15920 T19967 T19968 arg1Of interaction,with
R15921 T19969 T19970 arg1Of IκB-α,and
R15922 T19970 T19968 arg2Of and,with
R15923 T19971 T19970 arg2Of p65,and
R15924 T19974 T19972 arg2Of end,To
R15925 T19974 T19973 arg1Of end,this
R15926 T19978 T19976 arg1Of activity,the
R15927 T19978 T19977 arg1Of activity,NF-κB
R15928 T19978 T19979 arg1Of activity,was
R15929 T19978 T19980 arg2Of activity,monitored
R15930 T19978 T19986 arg1Of activity,using
R15931 T19978 T19990 arg1Of activity,silence
R15932 T19980 T19972 arg1Of monitored,To
R15933 T19980 T19975 arg1Of monitored,","
R15934 T19980 T19979 arg2Of monitored,was
R15935 T19980 T19981 arg1Of monitored,in
R15936 T19985 T19981 arg2Of infection,in
R15937 T19985 T19982 arg1Of infection,single
R15938 T19985 T19983 arg1Of infection,round
R15939 T19985 T19984 arg1Of infection,HIV-1
R15940 T19986 T19980 arg3Of using,monitored
R15941 T19988 T19986 arg2Of interference,using
R15942 T19988 T19987 arg1Of interference,RNA
R15943 T19990 T19986 arg3Of silence,using
R15944 T19990 T19989 arg1Of silence,to
R15945 T19993 T19990 arg2Of expression,silence
R15946 T19993 T19991 arg1Of expression,the
R15947 T19993 T19992 arg1Of expression,Tat
R15948 T19996 T19994 arg2Of approach,By
R15949 T19996 T19995 arg1Of approach,this
R15950 T19998 T19999 arg1Of we,avoided
R15951 T19999 T19994 arg1Of avoided,By
R15952 T19999 T19997 arg1Of avoided,","
R15953 T19999 T20007 arg1Of avoided,to
R15954 T20001 T19999 arg2Of perpetuation,avoided
R15955 T20001 T20000 arg1Of perpetuation,the
R15956 T20001 T20002 arg1Of perpetuation,of
R15957 T20005 T20002 arg2Of signaling,of
R15958 T20005 T20003 arg1Of signaling,NF-κB
R15959 T20005 T20004 arg1Of signaling,activation
R15960 T20007 T20006 arg1Of to,due
R15961 T20009 T20007 arg2Of rounds,to
R15962 T20009 T20008 arg1Of rounds,subsequent
R15963 T20009 T20010 arg1Of rounds,of
R15964 T20012 T20010 arg2Of entry,of
R15965 T20012 T20011 arg1Of entry,viral
R15966 T20012 T20013 arg1Of entry,in
R15967 T20016 T20013 arg2Of propagation,in
R15968 T20016 T20014 arg1Of propagation,cell
R15969 T20016 T20015 arg1Of propagation,culture
R15970 T20016 T20017 arg1Of propagation,(
R15971 T20018 T20017 arg2Of "30,31",(
R15972 T20019 T20017 arg3Of ),(
R15973 T20022 T20020 arg2Of infection,Upon
R15974 T20022 T20021 arg1Of infection,HIV-1
R15975 T20027 T20024 arg1Of activation,the
R15976 T20027 T20025 arg1Of activation,early
R15977 T20027 T20026 arg1Of activation,NF-κB
R15978 T20027 T20028 arg1Of activation,occurred
R15979 T20028 T20020 arg1Of occurred,Upon
R15980 T20028 T20023 arg1Of occurred,","
R15981 T20028 T20029 arg1Of occurred,concomitantly
R15982 T20028 T20030 arg1Of occurred,with
R15983 T20028 T20036 arg1Of occurred,in
R15984 T20028 T20042 arg1Of occurred,after
R15985 T20032 T20031 arg1Of activation,IKK
R15986 T20032 T20033 arg1Of activation,and
R15987 T20033 T20030 arg2Of and,with
R15988 T20035 T20033 arg2Of degradation,and
R15989 T20035 T20034 arg1Of degradation,IκB-α
R15990 T20038 T20036 arg2Of absence,in
R15991 T20038 T20037 arg1Of absence,the
R15992 T20038 T20039 arg1Of absence,of
R15993 T20041 T20039 arg2Of Soon,of
R15994 T20041 T20040 arg1Of Soon,Tat.
R15995 T20044 T20043 arg1Of shut,the
R15996 T20044 T20046 arg1Of shut,of
R15997 T20044 T20052 arg1Of shut,of
R15998 T20044 T20058 arg1Of shut,was
R15999 T20044 T20059 arg2Of shut,kept
R16000 T20044 T20060 arg1Of shut,elevated
R16001 T20046 T20045 arg1Of of,off
R16002 T20048 T20047 arg1Of activity,IKK
R16003 T20048 T20049 arg1Of activity,and
R16004 T20049 T20046 arg2Of and,of
R16005 T20051 T20049 arg2Of synthesis,and
R16006 T20051 T20050 arg1Of synthesis,new
R16007 T20053 T20052 arg2Of IκB-α,of
R16008 T20053 T20054 arg1Of IκB-α,","
R16009 T20057 T20054 arg2Of activity,","
R16010 T20057 T20055 arg1Of activity,the
R16011 T20057 T20056 arg1Of activity,NF-κB
R16012 T20059 T20042 arg2Of kept,after
R16013 T20059 T20058 arg2Of kept,was
R16014 T20059 T20061 arg1Of kept,in
R16015 T20059 T20066 arg1Of kept,","
R16016 T20059 T20067 arg1Of kept,while
R16017 T20060 T20059 arg3Of elevated,kept
R16018 T20063 T20061 arg2Of presence,in
R16019 T20063 T20062 arg1Of presence,the
R16020 T20063 T20064 arg1Of presence,of
R16021 T20065 T20064 arg2Of Tat,of
R16022 T20068 T20069 arg1Of it,was
R16023 T20068 T20071 arg2Of it,regulated
R16024 T20071 T20067 arg2Of regulated,while
R16025 T20071 T20069 arg2Of regulated,was
R16026 T20071 T20070 arg1Of regulated,down
R16027 T20071 T20072 arg1Of regulated,upon
R16028 T20073 T20072 arg2Of silencing,upon
R16029 T20073 T20074 arg1Of silencing,of
R16030 T20077 T20074 arg2Of gene,of
R16031 T20077 T20075 arg1Of gene,the
R16032 T20077 T20076 arg1Of gene,Tat
R16033 T20079 T20078 arg1Of findings,These
R16034 T20079 T20080 arg1Of findings,indicate
R16035 T20086 T20082 arg2Of infection,in
R16036 T20086 T20083 arg1Of infection,single
R16037 T20086 T20084 arg1Of infection,round
R16038 T20086 T20085 arg1Of infection,HIV-1
R16039 T20088 T20089 arg1Of Tat,enhanced
R16040 T20089 T20080 arg2Of enhanced,indicate
R16041 T20089 T20081 arg1Of enhanced,that
R16042 T20089 T20082 arg1Of enhanced,in
R16043 T20089 T20087 arg1Of enhanced,","
R16044 T20089 T20093 arg1Of enhanced,without
R16045 T20092 T20089 arg2Of activity,enhanced
R16046 T20092 T20090 arg1Of activity,the
R16047 T20092 T20091 arg1Of activity,NF-κB
R16048 T20094 T20093 arg2Of affecting,without
R16049 T20097 T20095 arg1Of activity,the
R16050 T20097 T20096 arg1Of activity,IKK
R16051 T20097 T20098 arg1Of activity,and
R16052 T20098 T20094 arg2Of and,affecting
R16053 T20100 T20098 arg2Of half-life,and
R16054 T20100 T20099 arg1Of half-life,the
R16055 T20100 T20101 arg1Of half-life,of
R16056 T20102 T20101 arg2Of IκB-α,of
R16057 T20104 T20103 arg1Of kinetic,Similar
R16058 T20104 T20105 arg1Of kinetic,of
R16059 T20104 T20108 arg1Of kinetic,occurred
R16060 T20107 T20105 arg2Of activation,of
R16061 T20107 T20106 arg1Of activation,NF-κB
R16062 T20108 T20109 arg1Of occurred,upon
R16063 T20110 T20109 arg2Of short-pulse,upon
R16064 T20110 T20111 arg1Of short-pulse,of
R16065 T20110 T20113 arg1Of short-pulse,in
R16066 T20112 T20111 arg2Of PMA,of
R16067 T20116 T20113 arg2Of cells,in
R16068 T20116 T20114 arg1Of cells,Tat-transfected
R16069 T20116 T20115 arg1Of cells,HeLa
R16070 T20116 T20117 arg1Of cells,","
R16071 T20116 T20118 arg1Of cells,where
R16072 T20119 T20120 arg1Of Tat,inhibited
R16073 T20120 T20118 arg2Of inhibited,where
R16074 T20120 T20124 arg1Of inhibited,off
R16075 T20120 T20127 arg1Of inhibited,in
R16076 T20123 T20120 arg2Of turn,inhibited
R16077 T20123 T20121 arg1Of turn,the
R16078 T20123 T20122 arg1Of turn,post-activation
R16079 T20124 T20125 arg1Of off,of
R16080 T20126 T20125 arg2Of NF-κB,of
R16081 T20127 T20129 arg1Of in,of
R16082 T20128 T20127 arg2Of presence,in
R16083 T20132 T20127 arg3Of IκB-α,in
R16084 T20132 T20130 arg1Of IκB-α,newly
R16085 T20132 T20131 arg2Of IκB-α,synthesized
R16086 T20135 T20133 arg1Of activation,The
R16087 T20135 T20134 arg1Of activation,Tat-dependent
R16088 T20135 T20136 arg1Of activation,of
R16089 T20135 T20138 arg1Of activation,correlated
R16090 T20137 T20136 arg2Of NF-κB,of
R16091 T20138 T20139 arg1Of correlated,with
R16092 T20141 T20139 arg2Of association,with
R16093 T20141 T20140 arg1Of association,the
R16094 T20141 T20142 arg1Of association,of
R16095 T20141 T20146 arg1Of association,with
R16096 T20145 T20142 arg2Of protein,of
R16097 T20145 T20143 arg1Of protein,the
R16098 T20145 T20144 arg1Of protein,viral
R16099 T20147 T20146 arg2Of IκB-α,with
R16100 T20147 T20148 arg1Of IκB-α,","
R16101 T20147 T20149 arg1Of IκB-α,which
R16102 T20147 T20150 arg1Of IκB-α,interfered
R16103 T20150 T20151 arg1Of interfered,with
R16104 T20153 T20151 arg2Of generation,with
R16105 T20153 T20152 arg1Of generation,the
R16106 T20153 T20154 arg1Of generation,of
R16107 T20157 T20154 arg2Of complex,of
R16108 T20157 T20155 arg1Of complex,the
R16109 T20157 T20156 arg1Of complex,IκB-α/p65
R16110 T20159 T20158 arg1Of evidence,This
R16111 T20159 T20160 arg1Of evidence,demonstrated
R16112 T20162 T20163 arg1Of Tat,competed
R16113 T20162 T20172 arg1Of Tat,prevented
R16114 T20163 T20164 arg1Of competed,for
R16115 T20163 T20171 arg1Of competed,and
R16116 T20166 T20164 arg2Of binding,for
R16117 T20166 T20165 arg1Of binding,the
R16118 T20166 T20167 arg1Of binding,of
R16119 T20166 T20169 arg1Of binding,to
R16120 T20168 T20167 arg2Of IκB-α,of
R16121 T20170 T20169 arg2Of p65,to
R16122 T20171 T20160 arg2Of and,demonstrated
R16123 T20171 T20161 arg1Of and,that
R16124 T20172 T20171 arg2Of prevented,and
R16125 T20175 T20172 arg2Of repression,prevented
R16126 T20175 T20173 arg1Of repression,the
R16127 T20175 T20174 arg1Of repression,IκB-α
R16128 T20175 T20176 arg1Of repression,of
R16129 T20177 T20176 arg2Of p65,of
R16130 T20180 T20178 arg2Of mechanism,As
R16131 T20180 T20179 arg1Of mechanism,additional
R16132 T20180 T20181 arg1Of mechanism,of
R16133 T20183 T20181 arg2Of activation,of
R16134 T20183 T20182 arg1Of activation,NF-κB
R16135 T20185 T20186 arg1Of Tat,associated
R16136 T20185 T20190 arg1Of Tat,increased
R16137 T20186 T20187 arg1Of associated,with
R16138 T20186 T20189 arg1Of associated,and
R16139 T20188 T20187 arg2Of p65,with
R16140 T20189 T20178 arg1Of and,As
R16141 T20189 T20184 arg1Of and,","
R16142 T20189 T20199 arg1Of and,;
R16143 T20190 T20189 arg2Of increased,and
R16144 T20194 T20190 arg2Of affinity,increased
R16145 T20194 T20191 arg1Of affinity,the
R16146 T20194 T20192 arg1Of affinity,p65
R16147 T20194 T20193 arg1Of affinity,binding
R16148 T20194 T20195 arg1Of affinity,to
R16149 T20198 T20195 arg2Of enhancer,to
R16150 T20198 T20196 arg1Of enhancer,the
R16151 T20198 T20197 arg1Of enhancer,NF-κB
R16152 T20201 T20200 arg1Of evidence,this
R16153 T20201 T20202 arg1Of evidence,was
R16154 T20201 T20203 arg2Of evidence,obtained
R16155 T20203 T20199 arg2Of obtained,;
R16156 T20203 T20202 arg2Of obtained,was
R16157 T20203 T20204 arg1Of obtained,with
R16158 T20206 T20204 arg2Of proteins,with
R16159 T20206 T20205 arg1Of proteins,recombinant
R16160 T20206 T20207 arg1Of proteins,indicating
R16161 T20211 T20209 arg1Of binding,the
R16162 T20211 T20210 arg1Of binding,stronger
R16163 T20211 T20212 arg1Of binding,of
R16164 T20211 T20214 arg1Of binding,to
R16165 T20211 T20216 arg1Of binding,was
R16166 T20213 T20212 arg2Of p65,of
R16167 T20215 T20214 arg2Of DNA,to
R16168 T20216 T20207 arg2Of was,indicating
R16169 T20216 T20208 arg1Of was,that
R16170 T20218 T20216 arg2Of consequence,was
R16171 T20218 T20217 arg1Of consequence,a
R16172 T20218 T20219 arg1Of consequence,of
R16173 T20218 T20222 arg1Of consequence,with
R16174 T20221 T20219 arg2Of association,of
R16175 T20221 T20220 arg1Of association,direct
R16176 T20223 T20222 arg2Of Tat,with
R16177 T20223 T20224 arg1Of Tat,","
R16178 T20223 T20225 arg1Of Tat,which
R16179 T20223 T20227 arg1Of Tat,caused
R16180 T20227 T20226 arg1Of caused,likely
R16181 T20230 T20227 arg2Of change,caused
R16182 T20230 T20228 arg1Of change,a
R16183 T20230 T20229 arg1Of change,conformational
R16184 T20230 T20231 arg1Of change,of
R16185 T20232 T20231 arg2Of p65,of
R16186 T20233 T20235 arg1Of We,demonstrated
R16187 T20235 T20234 arg1Of demonstrated,also
R16188 T20240 T20237 arg1Of sequence,the
R16189 T20240 T20238 arg1Of sequence,Tat
R16190 T20240 T20239 arg1Of sequence,cysteine-rich
R16191 T20240 T20241 arg1Of sequence,(
R16192 T20240 T20244 arg1Of sequence,was
R16193 T20240 T20245 arg2Of sequence,involved
R16194 T20242 T20241 arg2Of "C22,25,27",(
R16195 T20243 T20241 arg3Of ),(
R16196 T20245 T20235 arg2Of involved,demonstrated
R16197 T20245 T20236 arg1Of involved,that
R16198 T20245 T20244 arg2Of involved,was
R16199 T20245 T20246 arg1Of involved,in
R16200 T20248 T20246 arg2Of binding,in
R16201 T20248 T20247 arg1Of binding,the
R16202 T20248 T20249 arg1Of binding,to
R16203 T20251 T20249 arg2Of RHD,to
R16204 T20251 T20250 arg1Of RHD,the
R16205 T20251 T20252 arg1Of RHD,of
R16206 T20253 T20254 arg1Of p65,and
R16207 T20255 T20254 arg2Of NF-κB,and
R16208 T20256 T20252 arg2Of activation,of
R16209 T20256 T20253 arg1Of activation,p65
R16210 T20256 T20255 arg1Of activation,NF-κB
R16211 T20262 T20259 arg1Of sequence,the
R16212 T20262 T20260 arg1Of sequence,Tat
R16213 T20262 T20261 arg1Of sequence,arginine-rich
R16214 T20262 T20263 arg1Of sequence,(
R16215 T20262 T20266 arg1Of sequence,was
R16216 T20262 T20267 arg2Of sequence,required
R16217 T20264 T20263 arg2Of "R49,52,53,55,56,57",(
R16218 T20265 T20263 arg3Of ),(
R16219 T20267 T20257 arg1Of required,Differently
R16220 T20267 T20258 arg1Of required,","
R16221 T20267 T20266 arg2Of required,was
R16222 T20267 T20268 arg1Of required,for
R16223 T20270 T20268 arg2Of binding,for
R16224 T20270 T20269 arg1Of binding,the
R16225 T20270 T20271 arg1Of binding,to
R16226 T20270 T20282 arg1Of binding,for
R16227 T20271 T20281 arg1Of to,and
R16228 T20274 T20271 arg2Of ankyrin,to
R16229 T20274 T20272 arg1Of ankyrin,the
R16230 T20274 T20273 arg1Of ankyrin,sixth
R16231 T20274 T20275 arg1Of ankyrin,of
R16232 T20276 T20275 arg2Of IκB-α,of
R16233 T20276 T20277 arg1Of IκB-α,(
R16234 T20278 T20277 arg2Of "50,51",(
R16235 T20279 T20277 arg3Of ),(
R16236 T20281 T20280 arg1Of and,","
R16237 T20282 T20281 arg2Of for,and
R16238 T20283 T20282 arg2Of releasing,for
R16239 T20283 T20285 arg1Of releasing,from
R16240 T20284 T20283 arg2Of p65,releasing
R16241 T20288 T20285 arg2Of inhibition,from
R16242 T20288 T20286 arg1Of inhibition,the
R16243 T20288 T20287 arg1Of inhibition,IκB-α
R16244 T20291 T20290 arg1Of results,these
R16245 T20291 T20292 arg1Of results,demonstrated
R16246 T20292 T20289 arg1Of demonstrated,Altogether
R16247 T20294 T20295 arg1Of Tat,abolished
R16248 T20294 T20303 arg1Of Tat,hijacking
R16249 T20294 T20308 arg1Of Tat,shielding
R16250 T20294 T20316 arg1Of Tat,enforcing
R16251 T20295 T20292 arg2Of abolished,demonstrated
R16252 T20295 T20293 arg1Of abolished,that
R16253 T20295 T20302 arg1Of abolished,by
R16254 T20299 T20295 arg2Of regulation,abolished
R16255 T20299 T20296 arg1Of regulation,the
R16256 T20299 T20297 arg1Of regulation,negative
R16257 T20299 T20298 arg1Of regulation,feedback
R16258 T20299 T20300 arg1Of regulation,of
R16259 T20301 T20300 arg2Of NF-κB,of
R16260 T20303 T20307 arg1Of hijacking,","
R16261 T20303 T20308 modOf hijacking,shielding
R16262 T20303 T20315 arg1Of hijacking,and
R16263 T20306 T20303 arg2Of repressor,hijacking
R16264 T20306 T20304 arg1Of repressor,the
R16265 T20306 T20305 arg1Of repressor,IκB-α
R16266 T20308 T20310 arg1Of shielding,from
R16267 T20309 T20308 arg2Of p65,shielding
R16268 T20313 T20310 arg2Of embrace,from
R16269 T20313 T20311 arg1Of embrace,the
R16270 T20313 T20312 arg1Of embrace,IκB-α
R16271 T20315 T20302 arg2Of and,by
R16272 T20315 T20314 arg1Of and,","
R16273 T20316 T20315 arg2Of enforcing,and
R16274 T20319 T20316 arg2Of binding,enforcing
R16275 T20319 T20317 arg1Of binding,the
R16276 T20319 T20318 arg1Of binding,p65
R16277 T20319 T20320 arg1Of binding,to
R16278 T20321 T20320 arg2Of DNA,to
R16279 T20323 T20322 arg1Of evidence,Further
R16280 T20323 T20324 arg1Of evidence,of
R16281 T20323 T20329 arg1Of evidence,showed
R16282 T20326 T20324 arg2Of activation,of
R16283 T20326 T20325 arg1Of activation,Tat
R16284 T20326 T20327 arg1Of activation,of
R16285 T20328 T20327 arg2Of NF-κB,of
R16286 T20332 T20331 arg1Of Tat,wild-type
R16287 T20332 T20334 arg1Of Tat,and
R16288 T20334 T20329 arg2Of and,showed
R16289 T20334 T20330 arg1Of and,that
R16290 T20334 T20333 arg1Of and,","
R16291 T20334 T20335 arg1Of and,not
R16292 T20338 T20334 arg2Of mutants,and
R16293 T20338 T20336 arg1Of mutants,the
R16294 T20338 T20337 arg1Of mutants,Tat
R16295 T20338 T20339 arg1Of mutants,lacking
R16296 T20341 T20340 arg1Of arginine-,the
R16297 T20341 T20342 arg1Of arginine-,or
R16298 T20343 T20342 arg2Of cysteine-rich,or
R16299 T20344 T20341 arg1Of domains,arginine-
R16300 T20344 T20343 arg1Of domains,cysteine-rich
R16301 T20344 T20345 arg1Of domains,","
R16302 T20344 T20346 arg2Of domains,up-regulated
R16303 T20346 T20348 arg1Of up-regulated,vivo
R16304 T20348 T20347 arg1Of vivo,in
R16305 T20350 T20339 arg2Of expression,lacking
R16306 T20350 T20344 arg1Of expression,domains
R16307 T20350 T20349 arg1Of expression,the
R16308 T20350 T20351 arg1Of expression,of
R16309 T20353 T20351 arg2Of number,of
R16310 T20353 T20352 arg1Of number,a
R16311 T20353 T20354 arg1Of number,of
R16312 T20356 T20354 arg2Of genes,of
R16313 T20356 T20355 arg1Of genes,NF-κB-responsive
R16314 T20356 T20357 arg1Of genes,","
R16315 T20356 T20358 arg1Of genes,including
R16316 T20359 T20360 arg1Of MIP-1α,","
R16317 T20360 T20362 arg1Of ",",","
R16318 T20361 T20360 arg2Of CSF3,","
R16319 T20362 T20364 arg1Of ",",","
R16320 T20363 T20362 arg2Of LTA,","
R16321 T20364 T20366 arg1Of ",",and
R16322 T20365 T20364 arg2Of NFKBIA,","
R16323 T20366 T20358 arg2Of and,including
R16324 T20367 T20366 arg2Of TLR2,and
R16325 T20370 T20368 arg2Of analysis,By
R16326 T20370 T20369 arg1Of analysis,ChIP
R16327 T20372 T20373 arg1Of we,observed
R16328 T20373 T20368 arg1Of observed,By
R16329 T20373 T20371 arg1Of observed,","
R16330 T20375 T20376 arg1Of Tat,increased
R16331 T20375 T20391 arg1Of Tat,was
R16332 T20375 T20392 arg2Of Tat,recovered
R16333 T20376 T20390 arg1Of increased,and
R16334 T20378 T20376 arg2Of recruitment,increased
R16335 T20378 T20377 arg1Of recruitment,the
R16336 T20378 T20379 arg1Of recruitment,of
R16337 T20378 T20381 arg1Of recruitment,to
R16338 T20380 T20379 arg2Of p65,of
R16339 T20384 T20381 arg2Of enhancers,to
R16340 T20384 T20382 arg1Of enhancers,the
R16341 T20384 T20383 arg1Of enhancers,NF-κB
R16342 T20384 T20385 arg1Of enhancers,of
R16343 T20388 T20385 arg2Of genes,of
R16344 T20388 T20386 arg1Of genes,the
R16345 T20388 T20387 arg2Of genes,activated
R16346 T20390 T20373 arg2Of and,observed
R16347 T20390 T20374 arg1Of and,that
R16348 T20390 T20389 arg1Of and,","
R16349 T20392 T20390 arg2Of recovered,and
R16350 T20392 T20391 arg2Of recovered,was
R16351 T20392 T20393 arg1Of recovered,at
R16352 T20396 T20393 arg2Of sites,at
R16353 T20396 T20394 arg1Of sites,the
R16354 T20396 T20395 arg1Of sites,same
R16355 T20398 T20397 arg1Of interference,RNA
R16356 T20398 T20399 arg1Of interference,of
R16357 T20398 T20401 arg1Of interference,abolished
R16358 T20400 T20399 arg2Of p65,of
R16359 T20404 T20401 arg2Of occupancy,abolished
R16360 T20404 T20402 arg1Of occupancy,the
R16361 T20404 T20403 arg1Of occupancy,Tat
R16362 T20404 T20405 arg1Of occupancy,of
R16363 T20408 T20405 arg2Of enhancers,of
R16364 T20408 T20406 arg1Of enhancers,the
R16365 T20408 T20407 arg1Of enhancers,NF-κB
R16366 T20408 T20409 arg1Of enhancers,indicating
R16367 T20413 T20411 arg1Of binding,the
R16368 T20413 T20412 arg1Of binding,Tat
R16369 T20413 T20414 arg1Of binding,to
R16370 T20413 T20418 arg1Of binding,was
R16371 T20413 T20419 arg2Of binding,mediated
R16372 T20417 T20414 arg2Of sites,to
R16373 T20417 T20415 arg1Of sites,the
R16374 T20417 T20416 arg1Of sites,NF-κB
R16375 T20419 T20409 arg2Of mediated,indicating
R16376 T20419 T20410 arg1Of mediated,that
R16377 T20419 T20418 arg2Of mediated,was
R16378 T20421 T20419 arg1Of p65,mediated
R16379 T20421 T20420 arg2Of p65,by
R16380 T20423 T20422 arg1Of results,These
R16381 T20423 T20424 arg1Of results,were
R16382 T20423 T20425 arg1Of results,consistent
R16383 T20425 T20424 arg2Of consistent,were
R16384 T20425 T20426 arg1Of consistent,with
R16385 T20428 T20426 arg2Of evidence,with
R16386 T20428 T20427 arg1Of evidence,the
R16387 T20430 T20431 arg1Of Tat,displaced
R16388 T20430 T20446 arg1Of Tat,increased
R16389 T20431 T20433 arg1Of displaced,from
R16390 T20431 T20445 arg1Of displaced,and
R16391 T20432 T20431 arg2Of p65,displaced
R16392 T20435 T20433 arg2Of binding,from
R16393 T20435 T20434 arg1Of binding,the
R16394 T20435 T20436 arg1Of binding,to
R16395 T20437 T20436 arg2Of IκB-α,to
R16396 T20437 T20438 arg1Of IκB-α,(
R16397 T20440 T20441 arg1Of 2D,and
R16398 T20441 T20438 arg2Of and,(
R16399 T20441 T20439 arg1Of and,Figures
R16400 T20442 T20441 arg2Of 3C,and
R16401 T20443 T20438 arg3Of ),(
R16402 T20445 T20428 arg2Of and,evidence
R16403 T20445 T20429 arg1Of and,that
R16404 T20445 T20444 arg1Of and,","
R16405 T20446 T20445 arg2Of increased,and
R16406 T20446 T20452 arg1Of increased,through
R16407 T20451 T20446 arg2Of affinity,increased
R16408 T20451 T20447 arg1Of affinity,the
R16409 T20451 T20448 arg1Of affinity,p65
R16410 T20451 T20449 arg1Of affinity,DNA
R16411 T20451 T20450 arg1Of affinity,binding
R16412 T20453 T20452 arg2Of association,through
R16413 T20453 T20454 arg1Of association,(
R16414 T20456 T20455 arg1Of 4E,Figure
R16415 T20456 T20457 arg1Of 4E,and
R16416 T20457 T20454 arg2Of and,(
R16417 T20458 T20457 arg2Of F,and
R16418 T20459 T20454 arg3Of ),(
R16419 T20462 T20464 arg1Of Tat,increased
R16420 T20462 T20474 arg1Of Tat,associating
R16421 T20462 T20479 arg1Of Tat,interfering
R16422 T20464 T20460 arg1Of increased,Thus
R16423 T20464 T20461 arg1Of increased,","
R16424 T20464 T20463 arg1Of increased,likely
R16425 T20464 T20473 arg1Of increased,by
R16426 T20464 T20478 arg1Of increased,by
R16427 T20466 T20464 arg2Of recruitment,increased
R16428 T20466 T20465 arg1Of recruitment,the
R16429 T20466 T20467 arg1Of recruitment,of
R16430 T20466 T20469 arg1Of recruitment,to
R16431 T20468 T20467 arg2Of p65,of
R16432 T20472 T20469 arg2Of promoters,to
R16433 T20472 T20470 arg1Of promoters,the
R16434 T20472 T20471 arg1Of promoters,NF-κB-dependent
R16435 T20473 T20477 arg1Of by,and
R16436 T20474 T20473 arg2Of associating,by
R16437 T20474 T20475 arg1Of associating,with
R16438 T20476 T20475 arg2Of p65,with
R16439 T20478 T20477 arg2Of by,and
R16440 T20479 T20478 arg2Of interfering,by
R16441 T20479 T20480 arg1Of interfering,with
R16442 T20482 T20480 arg2Of assembly,with
R16443 T20482 T20481 arg1Of assembly,the
R16444 T20482 T20483 arg1Of assembly,of
R16445 T20484 T20483 arg2Of p65,of
R16446 T20484 T20485 arg1Of p65,with
R16447 T20488 T20485 arg2Of IκB-α,with
R16448 T20488 T20486 arg1Of IκB-α,the
R16449 T20488 T20487 arg1Of IκB-α,repressor
R16450 T20490 T20489 arg2Of interest,Of
R16451 T20492 T20493 arg1Of IκB-α,was
R16452 T20492 T20494 arg2Of IκB-α,found
R16453 T20492 T20495 arg2Of IκB-α,associated
R16454 T20494 T20489 arg1Of found,Of
R16455 T20494 T20491 arg1Of found,","
R16456 T20494 T20493 arg2Of found,was
R16457 T20495 T20494 arg3Of associated,found
R16458 T20495 T20496 arg1Of associated,to
R16459 T20495 T20500 arg1Of associated,in
R16460 T20499 T20496 arg2Of enhancers,to
R16461 T20499 T20497 arg1Of enhancers,the
R16462 T20499 T20498 arg1Of enhancers,NF-κB
R16463 T20500 T20502 arg1Of in,of
R16464 T20501 T20500 arg2Of absence,in
R16465 T20503 T20500 arg3Of Tat,in
R16466 T20503 T20504 arg1Of Tat,","
R16467 T20503 T20505 arg1Of Tat,where
R16468 T20506 T20507 arg1Of it,was
R16469 T20506 T20508 arg2Of it,displaced
R16470 T20508 T20505 arg2Of displaced,where
R16471 T20508 T20507 arg2Of displaced,was
R16472 T20508 T20509 arg1Of displaced,in
R16473 T20510 T20509 arg2Of presence,in
R16474 T20510 T20511 arg1Of presence,of
R16475 T20512 T20511 arg2Of Tat.,of
R16476 T20514 T20513 arg1Of results,These
R16477 T20514 T20515 arg1Of results,suggest
R16478 T20515 T20508 arg3Of suggest,displaced
R16479 T20519 T20515 arg2Of role,suggest
R16480 T20519 T20516 arg1Of role,a
R16481 T20519 T20517 arg1Of role,negative
R16482 T20519 T20518 arg1Of role,regulatory
R16483 T20519 T20520 arg1Of role,of
R16484 T20519 T20522 arg1Of role,in
R16485 T20521 T20520 arg2Of IκB-α,of
R16486 T20524 T20522 arg2Of regulation,in
R16487 T20524 T20523 arg1Of regulation,gene
R16488 T20524 T20525 arg1Of regulation,through
R16489 T20526 T20525 arg2Of occupancy,through
R16490 T20526 T20527 arg1Of occupancy,of
R16491 T20529 T20527 arg2Of promoters,of
R16492 T20529 T20528 arg1Of promoters,specific
R16493 T20532 T20533 arg1Of IκB-α,was
R16494 T20532 T20534 arg2Of IκB-α,found
R16495 T20532 T20535 arg2Of IκB-α,associated
R16496 T20534 T20530 arg1Of found,Indeed
R16497 T20534 T20531 arg1Of found,","
R16498 T20534 T20533 arg2Of found,was
R16499 T20534 T20543 arg1Of found,","
R16500 T20534 T20544 arg1Of found,from
R16501 T20535 T20534 arg3Of associated,found
R16502 T20535 T20536 arg1Of associated,with
R16503 T20535 T20539 arg1Of associated,at
R16504 T20538 T20536 arg2Of deacetylases,with
R16505 T20538 T20537 arg1Of deacetylases,hystone
R16506 T20542 T20539 arg2Of promoter,at
R16507 T20542 T20540 arg1Of promoter,the
R16508 T20542 T20541 arg1Of promoter,hes1
R16509 T20545 T20544 arg2Of where,from
R16510 T20546 T20547 arg1Of it,was
R16511 T20546 T20548 arg2Of it,removed
R16512 T20548 T20545 arg1Of removed,where
R16513 T20548 T20547 arg2Of removed,was
R16514 T20548 T20549 arg1Of removed,following
R16515 T20551 T20549 arg2Of stimulation,following
R16516 T20551 T20550 arg1Of stimulation,TNF-α
R16517 T20551 T20552 arg1Of stimulation,causing
R16518 T20554 T20553 arg1Of acetylation,histone
R16519 T20554 T20555 arg1Of acetylation,and
R16520 T20555 T20552 arg2Of and,causing
R16521 T20558 T20555 arg2Of activation,and
R16522 T20558 T20556 arg1Of activation,hes1
R16523 T20558 T20557 arg1Of activation,transcriptional
R16524 T20558 T20559 arg1Of activation,(
R16525 T20560 T20559 arg2Of 65,(
R16526 T20561 T20559 arg3Of ),(
R16527 T20564 T20562 arg1Of mechanism,A
R16528 T20564 T20563 arg1Of mechanism,similar
R16529 T20564 T20565 arg1Of mechanism,of
R16530 T20564 T20568 arg1Of mechanism,could
R16531 T20564 T20569 arg1Of mechanism,apply
R16532 T20567 T20565 arg2Of regulation,of
R16533 T20567 T20566 arg1Of regulation,gene
R16534 T20569 T20568 arg2Of apply,could
R16535 T20569 T20570 arg1Of apply,to
R16536 T20573 T20570 arg2Of genes,to
R16537 T20573 T20571 arg1Of genes,the
R16538 T20573 T20572 arg1Of genes,NF-κB-dependent
R16539 T20573 T20574 arg2Of genes,analysed
R16540 T20573 T20578 arg1Of genes,","
R16541 T20573 T20579 arg1Of genes,where
R16542 T20574 T20575 arg1Of analysed,in
R16543 T20577 T20575 arg2Of study,in
R16544 T20577 T20576 arg1Of study,this
R16545 T20580 T20581 arg1Of Tat,could
R16546 T20580 T20582 arg1Of Tat,activate
R16547 T20580 T20587 arg1Of Tat,removing
R16548 T20580 T20590 arg1Of Tat,promoting
R16549 T20582 T20579 arg2Of activate,where
R16550 T20582 T20581 arg2Of activate,could
R16551 T20582 T20586 arg1Of activate,by
R16552 T20585 T20582 arg2Of expression,activate
R16553 T20585 T20583 arg1Of expression,the
R16554 T20585 T20584 arg1Of expression,gene
R16555 T20587 T20589 arg1Of removing,and
R16556 T20588 T20587 arg2Of IκB-α,removing
R16557 T20589 T20586 arg2Of and,by
R16558 T20590 T20589 arg2Of promoting,and
R16559 T20593 T20590 arg2Of loading,promoting
R16560 T20593 T20591 arg1Of loading,the
R16561 T20593 T20592 arg1Of loading,p65
R16562 T20593 T20594 arg1Of loading,(
R16563 T20595 T20594 arg2Of Figure,(
R16564 T20595 T20596 arg1Of Figure,7
R16565 T20597 T20594 arg3Of ),(
R16566 T20600 T20598 arg1Of relevance,The
R16567 T20600 T20599 arg1Of relevance,physiological
R16568 T20600 T20601 arg1Of relevance,of
R16569 T20600 T20607 arg1Of relevance,was
R16570 T20600 T20608 arg2Of relevance,demonstrated
R16571 T20604 T20601 arg2Of talk,of
R16572 T20604 T20602 arg1Of talk,Tat
R16573 T20604 T20603 arg1Of talk,cross
R16574 T20604 T20605 arg1Of talk,with
R16575 T20606 T20605 arg2Of NF-κB,with
R16576 T20608 T20607 arg2Of demonstrated,was
R16577 T20608 T20609 arg1Of demonstrated,in
R16578 T20612 T20609 arg2Of infection,in
R16579 T20612 T20610 arg1Of infection,the
R16580 T20612 T20611 arg1Of infection,HIV-1
R16581 T20612 T20613 arg1Of infection,of
R16582 T20612 T20616 arg1Of infection,","
R16583 T20612 T20617 arg1Of infection,where
R16584 T20615 T20613 arg2Of monocytes,of
R16585 T20615 T20614 arg1Of monocytes,human
R16586 T20620 T20618 arg1Of protein,HIV-1-encoded
R16587 T20620 T20619 arg1Of protein,Tat
R16588 T20620 T20621 arg2Of protein,counteracted
R16589 T20620 T20635 arg1Of protein,sustained
R16590 T20621 T20624 arg1Of counteracted,off
R16591 T20621 T20627 arg1Of counteracted,","
R16592 T20621 T20628 arg1Of counteracted,as
R16593 T20623 T20621 arg3Of turn,counteracted
R16594 T20623 T20622 arg1Of turn,post-activation
R16595 T20624 T20625 arg1Of off,of
R16596 T20626 T20625 arg2Of NF-κB,of
R16597 T20629 T20628 arg2Of shown,as
R16598 T20629 T20630 arg1Of shown,by
R16599 T20630 T20631 arg1Of by,:
R16600 T20633 T20632 arg1Of i,(
R16601 T20633 T20634 arg1Of i,)
R16602 T20635 T20617 arg2Of sustained,where
R16603 T20635 T20633 arg1Of sustained,i
R16604 T20637 T20636 arg1Of activity,NF-κB
R16605 T20637 T20638 arg1Of activity,by
R16606 T20637 T20640 arg1Of activity,in
R16607 T20637 T20646 arg1Of activity,;
R16608 T20639 T20638 arg2Of Tat,by
R16609 T20641 T20640 arg2Of presence,in
R16610 T20641 T20642 arg1Of presence,of
R16611 T20644 T20643 arg1Of synthesized,newly
R16612 T20645 T20642 arg2Of IκB-α,of
R16613 T20645 T20644 arg1Of IκB-α,synthesized
R16614 T20646 T20635 arg2Of ;,sustained
R16615 T20648 T20647 arg1Of ii,(
R16616 T20648 T20649 arg1Of ii,)
R16617 T20650 T20648 arg1Of coimmunoprecipitation,ii
R16618 T20650 T20651 arg1Of coimmunoprecipitation,of
R16619 T20650 T20653 arg1Of coimmunoprecipitation,with
R16620 T20650 T20657 arg1Of coimmunoprecipitation,;
R16621 T20652 T20651 arg2Of Tat,of
R16622 T20654 T20655 arg1Of IκB-α,and
R16623 T20655 T20653 arg2Of and,with
R16624 T20656 T20655 arg2Of p65,and
R16625 T20657 T20665 arg1Of ;,dependent
R16626 T20657 T20670 arg1Of ;,;
R16627 T20659 T20660 arg1Of iii,)
R16628 T20661 T20657 arg2Of induction,;
R16629 T20661 T20658 arg1Of induction,(
R16630 T20661 T20659 arg1Of induction,iii
R16631 T20661 T20662 arg1Of induction,of
R16632 T20664 T20662 arg2Of expression,of
R16633 T20664 T20663 arg1Of expression,MIP-1α
R16634 T20665 T20666 arg1Of dependent,on
R16635 T20667 T20668 arg1Of Tat,and
R16636 T20668 T20666 arg2Of and,on
R16637 T20669 T20668 arg2Of p65,and
R16638 T20670 T20646 arg2Of ;,;
R16639 T20672 T20673 arg1Of iv,)
R16640 T20675 T20670 arg2Of occupancy,;
R16641 T20675 T20671 arg1Of occupancy,(
R16642 T20675 T20672 arg1Of occupancy,iv
R16643 T20675 T20674 arg1Of occupancy,Tat
R16644 T20675 T20676 arg1Of occupancy,of
R16645 T20680 T20676 arg2Of enhancer,of
R16646 T20680 T20677 arg1Of enhancer,the
R16647 T20680 T20678 arg1Of enhancer,MIP-1α
R16648 T20680 T20679 arg1Of enhancer,NF-κB
R16649 T20680 T20681 arg2Of enhancer,associated
R16650 T20681 T20682 arg1Of associated,with
R16651 T20684 T20682 arg2Of recruitment,with
R16652 T20684 T20683 arg2Of recruitment,increased
R16653 T20684 T20685 arg1Of recruitment,of
R16654 T20686 T20685 arg2Of p65,of
R16655 T20688 T20687 arg1Of study,This
R16656 T20688 T20689 arg1Of study,supports
R16657 T20689 T20695 arg1Of supports,through
R16658 T20692 T20689 arg2Of action,supports
R16659 T20692 T20690 arg1Of action,the
R16660 T20692 T20691 arg1Of action,pro-inflammatory
R16661 T20692 T20693 arg1Of action,of
R16662 T20694 T20693 arg2Of Tat,of
R16663 T20697 T20695 arg2Of interaction,through
R16664 T20697 T20696 arg1Of interaction,physical
R16665 T20697 T20698 arg1Of interaction,with
R16666 T20699 T20700 arg1Of p65,and
R16667 T20700 T20698 arg2Of and,with
R16668 T20701 T20700 arg2Of IκB-α,and
R16669 T20704 T20702 arg1Of cytokines,Several
R16670 T20704 T20703 arg1Of cytokines,inflammatory
R16671 T20704 T20705 arg1Of cytokines,under
R16672 T20704 T20711 arg1Of cytokines,are
R16673 T20704 T20712 arg1Of cytokines,hyper-expressed
R16674 T20708 T20705 arg2Of control,under
R16675 T20708 T20706 arg1Of control,the
R16676 T20708 T20707 arg1Of control,transcriptional
R16677 T20708 T20709 arg1Of control,of
R16678 T20710 T20709 arg2Of NF-κB,of
R16679 T20712 T20711 arg2Of hyper-expressed,are
R16680 T20712 T20713 arg1Of hyper-expressed,in
R16681 T20716 T20713 arg2Of individuals,in
R16682 T20716 T20714 arg1Of individuals,HIV-1
R16683 T20716 T20715 arg1Of individuals,infected
R16684 T20716 T20717 arg1Of individuals,","
R16685 T20716 T20718 arg1Of individuals,including
R16686 T20719 T20720 arg1Of IL-6,(
R16687 T20719 T20723 arg1Of IL-6,","
R16688 T20721 T20720 arg2Of "66,67",(
R16689 T20722 T20720 arg3Of ),(
R16690 T20723 T20729 arg1Of ",",and
R16691 T20724 T20723 arg2Of TNF-α,","
R16692 T20724 T20725 arg1Of TNF-α,(
R16693 T20726 T20725 arg2Of 68,(
R16694 T20727 T20725 arg3Of ),(
R16695 T20729 T20718 arg2Of and,including
R16696 T20729 T20728 arg1Of and,","
R16697 T20730 T20729 arg2Of MIP-1α,and
R16698 T20730 T20731 arg1Of MIP-1α,(
R16699 T20732 T20731 arg2Of "57–62,69–71",(
R16700 T20733 T20731 arg3Of ),(
R16701 T20736 T20734 arg2Of case,In
R16702 T20736 T20735 arg1Of case,the
R16703 T20736 T20737 arg1Of case,of
R16704 T20738 T20739 arg1Of TNF-α,and
R16705 T20739 T20737 arg2Of and,of
R16706 T20740 T20739 arg2Of IL-6,and
R16707 T20742 T20743 arg1Of Tat,activated
R16708 T20742 T20748 arg1Of Tat,binding
R16709 T20742 T20761 arg1Of Tat,promoting
R16710 T20743 T20734 arg1Of activated,In
R16711 T20743 T20741 arg1Of activated,","
R16712 T20743 T20747 arg1Of activated,by
R16713 T20746 T20743 arg2Of expression,activated
R16714 T20746 T20744 arg1Of expression,the
R16715 T20746 T20745 arg1Of expression,cytokine
R16716 T20748 T20749 arg1Of binding,to
R16717 T20748 T20758 arg1Of binding,","
R16718 T20753 T20749 arg2Of loop,to
R16719 T20753 T20750 arg1Of loop,the
R16720 T20753 T20751 arg1Of loop,TAR-like
R16721 T20753 T20752 arg1Of loop,stem
R16722 T20753 T20754 arg1Of loop,of
R16723 T20757 T20754 arg2Of transcript,of
R16724 T20757 T20755 arg1Of transcript,the
R16725 T20757 T20756 arg1Of transcript,5′
R16726 T20758 T20747 arg2Of ",",by
R16727 T20761 T20758 arg2Of promoting,","
R16728 T20761 T20759 arg1Of promoting,thus
R16729 T20761 T20760 arg1Of promoting,likely
R16730 T20764 T20761 arg2Of elongation,promoting
R16731 T20764 T20762 arg1Of elongation,the
R16732 T20764 T20763 arg1Of elongation,transcriptional
R16733 T20764 T20765 arg1Of elongation,(
R16734 T20766 T20765 arg2Of "33,37,47",(
R16735 T20767 T20765 arg3Of ),(
R16736 T20770 T20771 arg1Of we,have
R16737 T20770 T20772 arg1Of we,shown
R16738 T20772 T20768 arg1Of shown,Here
R16739 T20772 T20769 arg1Of shown,","
R16740 T20772 T20771 arg2Of shown,have
R16741 T20777 T20774 arg1Of activation,the
R16742 T20777 T20775 arg1Of activation,Tat-dependent
R16743 T20777 T20776 arg1Of activation,transcriptional
R16744 T20777 T20778 arg1Of activation,of
R16745 T20777 T20784 arg1Of activation,required
R16746 T20780 T20778 arg2Of number,of
R16747 T20780 T20779 arg1Of number,a
R16748 T20780 T20781 arg1Of number,of
R16749 T20783 T20781 arg2Of genes,of
R16750 T20783 T20782 arg1Of genes,pro-inflammatory
R16751 T20784 T20772 arg2Of required,shown
R16752 T20784 T20773 arg1Of required,that
R16753 T20784 T20795 arg1Of required,together
R16754 T20786 T20784 arg2Of assembly,required
R16755 T20786 T20785 arg1Of assembly,the
R16756 T20786 T20787 arg1Of assembly,of
R16757 T20786 T20789 arg1Of assembly,with
R16758 T20786 T20791 arg1Of assembly,at
R16759 T20788 T20787 arg2Of Tat,of
R16760 T20790 T20789 arg2Of p65,with
R16761 T20794 T20791 arg2Of enhancer,at
R16762 T20794 T20792 arg1Of enhancer,the
R16763 T20794 T20793 arg1Of enhancer,NF-κB
R16764 T20795 T20796 arg1Of together,with
R16765 T20798 T20796 arg2Of displacement,with
R16766 T20798 T20797 arg1Of displacement,the
R16767 T20798 T20799 arg1Of displacement,of
R16768 T20800 T20799 arg2Of IκB-α,of
R16769 T20800 T20801 arg1Of IκB-α,(
R16770 T20802 T20801 arg2Of Figure,(
R16771 T20802 T20803 arg1Of Figure,5
R16772 T20804 T20801 arg3Of ),(
R16773 T20809 T20807 arg2Of set,in
R16774 T20809 T20808 arg1Of set,the
R16775 T20809 T20810 arg1Of set,of
R16776 T20813 T20810 arg2Of genes,of
R16777 T20813 T20811 arg1Of genes,distinct
R16778 T20813 T20812 arg1Of genes,NF-κB-responsive
R16779 T20815 T20816 arg1Of Tat,acted
R16780 T20816 T20805 arg1Of acted,Thus
R16781 T20816 T20806 arg1Of acted,","
R16782 T20816 T20807 arg1Of acted,in
R16783 T20816 T20814 arg1Of acted,","
R16784 T20816 T20817 arg1Of acted,as
R16785 T20819 T20817 arg2Of component,as
R16786 T20819 T20818 arg1Of component,a
R16787 T20819 T20820 arg1Of component,of
R16788 T20824 T20820 arg2Of complex,of
R16789 T20824 T20821 arg1Of complex,the
R16790 T20824 T20822 arg1Of complex,transcriptional
R16791 T20824 T20823 arg1Of complex,initiation
R16792 T20824 T20825 arg1Of complex,","
R16793 T20824 T20826 arg1Of complex,which
R16794 T20824 T20827 arg1Of complex,is
R16795 T20824 T20828 arg1Of complex,consistent
R16796 T20828 T20827 arg2Of consistent,is
R16797 T20828 T20829 arg1Of consistent,with
R16798 T20831 T20829 arg2Of reports,with
R16799 T20831 T20830 arg1Of reports,previous
R16800 T20831 T20832 arg1Of reports,on
R16801 T20831 T20834 arg1Of reports,promoting
R16802 T20833 T20832 arg2Of Tat,on
R16803 T20834 T20837 arg1Of promoting,via
R16804 T20836 T20834 arg2Of transcription,promoting
R16805 T20836 T20835 arg1Of transcription,the
R16806 T20839 T20837 arg2Of motifs,via
R16807 T20839 T20838 arg1Of motifs,DNA
R16808 T20839 T20840 arg1Of motifs,(
R16809 T20841 T20840 arg2Of "72,73",(
R16810 T20842 T20840 arg3Of ),(
R16811 T20843 T20844 arg1Of Overproduction,of
R16812 T20843 T20847 arg1Of Overproduction,is
R16813 T20843 T20848 arg2Of Overproduction,considered
R16814 T20846 T20844 arg2Of cytokines,of
R16815 T20846 T20845 arg1Of cytokines,pro-inflammatory
R16816 T20848 T20847 arg2Of considered,is
R16817 T20851 T20848 arg3Of mechanism,considered
R16818 T20851 T20849 arg1Of mechanism,a
R16819 T20851 T20850 arg1Of mechanism,major
R16820 T20851 T20852 arg1Of mechanism,of
R16821 T20854 T20853 arg1Of deregulation,immune
R16822 T20854 T20855 arg1Of deregulation,(
R16823 T20854 T20858 arg1Of deregulation,and
R16824 T20856 T20855 arg2Of 26,(
R16825 T20857 T20855 arg3Of ),(
R16826 T20858 T20852 arg2Of and,of
R16827 T20860 T20858 arg2Of dysfunction,and
R16828 T20860 T20859 arg1Of dysfunction,neuron
R16829 T20860 T20861 arg1Of dysfunction,in
R16830 T20862 T20861 arg2Of AIDS,in
R16831 T20862 T20863 arg1Of AIDS,(
R16832 T20864 T20863 arg2Of "74,75",(
R16833 T20865 T20863 arg3Of ),(
R16834 T20868 T20866 arg2Of scenario,In
R16835 T20868 T20867 arg1Of scenario,this
R16836 T20870 T20871 arg1Of inhibition,of
R16837 T20870 T20874 arg1Of inhibition,could
R16838 T20870 T20875 arg1Of inhibition,lead
R16839 T20873 T20871 arg2Of activity,of
R16840 T20873 T20872 arg1Of activity,NF-κB
R16841 T20875 T20866 arg1Of lead,In
R16842 T20875 T20869 arg1Of lead,","
R16843 T20875 T20874 arg2Of lead,could
R16844 T20875 T20876 arg1Of lead,to
R16845 T20879 T20876 arg2Of strategy,to
R16846 T20879 T20877 arg1Of strategy,a
R16847 T20879 T20878 arg1Of strategy,therapeutic
R16848 T20879 T20880 arg1Of strategy,for
R16849 T20881 T20880 arg2Of counteracting,for
R16850 T20884 T20881 arg2Of production,counteracting
R16851 T20884 T20882 arg1Of production,the
R16852 T20884 T20883 arg1Of production,abnormal
R16853 T20884 T20885 arg1Of production,of
R16854 T20884 T20890 arg1Of production,in
R16855 T20887 T20886 arg1Of cytokines,pro-inflammatory
R16856 T20887 T20888 arg1Of cytokines,and
R16857 T20888 T20885 arg2Of and,of
R16858 T20889 T20888 arg2Of chemokines,and
R16859 T20892 T20890 arg2Of infection,in
R16860 T20892 T20891 arg1Of infection,HIV-1
R16861 T20894 T20893 arg1Of inhibitors,NF-κB
R16862 T20894 T20895 arg1Of inhibitors,","
R16863 T20894 T20897 arg1Of inhibitors,as
R16864 T20894 T20906 arg1Of inhibitors,reduced
R16865 T20897 T20896 arg1Of as,such
R16866 T20898 T20899 arg1Of anti-oxidants,","
R16867 T20899 T20901 arg1Of ",",and
R16868 T20900 T20899 arg2Of proteasome,","
R16869 T20901 T20897 arg2Of and,as
R16870 T20903 T20901 arg2Of inhibitors,and
R16871 T20903 T20902 arg1Of inhibitors,IKK
R16872 T20906 T20904 arg1Of reduced,","
R16873 T20906 T20905 arg1Of reduced,significantly
R16874 T20906 T20918 arg1Of reduced,;
R16875 T20909 T20907 arg1Of replication,the
R16876 T20909 T20908 arg1Of replication,HIV-1
R16877 T20909 T20910 arg1Of replication,and
R16878 T20910 T20906 arg2Of and,reduced
R16879 T20914 T20910 arg2Of response,and
R16880 T20914 T20911 arg1Of response,the
R16881 T20914 T20912 arg2Of response,associated
R16882 T20914 T20913 arg1Of response,inflammatory
R16883 T20914 T20915 arg1Of response,(
R16884 T20916 T20915 arg2Of "76,77",(
R16885 T20917 T20915 arg3Of ),(
R16886 T20923 T20921 arg1Of inhibitors,these
R16887 T20923 T20922 arg1Of inhibitors,NF-κB
R16888 T20923 T20924 arg1Of inhibitors,acted
R16889 T20924 T20918 arg2Of acted,;
R16890 T20924 T20919 arg1Of acted,however
R16891 T20924 T20920 arg1Of acted,","
R16892 T20924 T20925 arg1Of acted,indiscriminately
R16893 T20924 T20926 arg1Of acted,in
R16894 T20928 T20929 arg1Of HIV-1-infected,and
R16895 T20929 T20927 arg1Of and,both
R16896 T20930 T20929 arg2Of uninfected,and
R16897 T20931 T20926 arg2Of cells,in
R16898 T20931 T20928 arg1Of cells,HIV-1-infected
R16899 T20931 T20930 arg1Of cells,uninfected
R16900 T20933 T20932 arg1Of evidence,The
R16901 T20933 T20945 arg1Of evidence,may
R16902 T20933 T20946 arg1Of evidence,lead
R16903 T20935 T20936 arg1Of Tat,activates
R16904 T20936 T20933 arg2Of activates,evidence
R16905 T20936 T20934 arg1Of activates,that
R16906 T20936 T20938 arg1Of activates,through
R16907 T20937 T20936 arg2Of NF-κB,activates
R16908 T20940 T20938 arg2Of interaction,through
R16909 T20940 T20939 arg1Of interaction,direct
R16910 T20940 T20941 arg1Of interaction,with
R16911 T20942 T20943 arg1Of IκB-α,and
R16912 T20943 T20941 arg2Of and,with
R16913 T20944 T20943 arg2Of p65,and
R16914 T20946 T20945 arg2Of lead,may
R16915 T20946 T20947 arg1Of lead,to
R16916 T20949 T20947 arg2Of inhibitors,to
R16917 T20949 T20948 arg1Of inhibitors,specific
R16918 T20949 T20950 modOf inhibitors,to
R16919 T20951 T20950 arg1Of counteract,to
R16920 T20955 T20951 arg2Of action,counteract
R16921 T20955 T20952 arg1Of action,the
R16922 T20955 T20953 arg1Of action,Tat
R16923 T20955 T20954 arg1Of action,pro-inflammatory
R19354 T24359 T24360 arg1Of Tat,enhances
R19355 T24359 T24368 arg1Of Tat,associating
R19356 T24359 T24372 arg1Of Tat,counteracting
R19357 T24360 T24367 arg1Of enhances,by
R19358 T24363 T24360 arg2Of activity,enhances
R19359 T24363 T24361 arg1Of activity,the
R19360 T24363 T24362 arg1Of activity,NF-κB
R19361 T24363 T24364 arg1Of activity,following
R19362 T24366 T24364 arg2Of stimulation,following
R19363 T24366 T24365 arg1Of stimulation,PMA
R19364 T24368 T24369 arg1Of associating,with
R19365 T24368 T24371 arg1Of associating,and
R19366 T24370 T24369 arg2Of IκB-α,with
R19367 T24371 T24367 arg2Of and,by
R19368 T24372 T24371 arg2Of counteracting,and
R19369 T24375 T24372 arg2Of repression,counteracting
R19370 T24375 T24373 arg1Of repression,the
R19371 T24375 T24374 arg1Of repression,NF-κB
R19372 T24377 T24376 arg1Of cells,HeLa
R19373 T24377 T24378 arg1Of cells,(
R19374 T24377 T24381 arg1Of cells,were
R19375 T24377 T24382 arg2Of cells,transfected
R19376 T24379 T24378 arg2Of 5 × 106,(
R19377 T24380 T24378 arg3Of ),(
R19378 T24382 T24381 arg2Of transfected,were
R19379 T24382 T24383 arg1Of transfected,with
R19380 T24382 T24393 arg1Of transfected,and
R19381 T24384 T24385 arg1Of p3xFLAG-Tat,or
R19382 T24385 T24383 arg2Of or,with
R19383 T24388 T24385 arg2Of vector,or
R19384 T24388 T24386 arg1Of vector,p3xFLAG
R19385 T24388 T24387 arg1Of vector,empty
R19386 T24388 T24389 arg1Of vector,(
R19387 T24390 T24389 arg2Of 5 µg,(
R19388 T24391 T24389 arg3Of ),(
R19389 T24393 T24392 arg1Of and,","
R19390 T24394 T24396 arg1Of 48 h,were
R19391 T24394 T24397 arg2Of 48 h,stimulated
R19392 T24394 T24406 arg1Of 48 h,left
R19393 T24394 T24409 arg1Of 48 h,washed
R19394 T24394 T24414 arg1Of 48 h,harvested
R19395 T24397 T24396 arg2Of stimulated,were
R19396 T24397 T24398 arg1Of stimulated,with
R19397 T24397 T24405 arg1Of stimulated,or
R19398 T24399 T24398 arg2Of PMA,with
R19399 T24399 T24400 arg1Of PMA,(
R19400 T24401 T24400 arg2Of 5 min,(
R19401 T24401 T24402 arg1Of 5 min,","
R19402 T24403 T24402 arg2Of 20 ng/ml,","
R19403 T24404 T24400 arg3Of ),(
R19404 T24405 T24408 arg1Of or,","
R19405 T24406 T24405 arg2Of left,or
R19406 T24407 T24406 arg2Of unstimulated,left
R19407 T24408 T24393 arg2Of ",",and
R19408 T24408 T24395 arg1Of ",",later
R19409 T24409 T24410 arg1Of washed,twice
R19410 T24409 T24411 arg1Of washed,with
R19411 T24409 T24413 arg1Of washed,and
R19412 T24412 T24411 arg2Of DMEM,with
R19413 T24413 T24408 arg2Of and,","
R19414 T24414 T24413 arg2Of harvested,and
R19415 T24414 T24415 arg1Of harvested,at
R19416 T24418 T24415 arg2Of times,at
R19417 T24418 T24416 arg1Of times,the
R19418 T24418 T24417 arg1Of times,indicated
R19419 T24419 T24420 arg1Of Nuclear,and
R19420 T24421 T24420 arg2Of cytosolic,and
R19421 T24422 T24419 arg1Of extracts,Nuclear
R19422 T24422 T24421 arg1Of extracts,cytosolic
R19423 T24422 T24423 arg1Of extracts,were
R19424 T24422 T24424 arg2Of extracts,prepared
R19425 T24424 T24423 arg2Of prepared,were
R19426 T24424 T24425 arg1Of prepared,for
R19427 T24427 T24425 arg2Of analysis.,for
R19428 T24427 T24426 arg1Of analysis.,further
R19429 T24427 T24433 modOf analysis.,were
R19430 T24429 T24428 arg2Of A,(
R19431 T24430 T24428 arg3Of ),(
R19432 T24432 T24428 arg1Of extracts,(
R19433 T24432 T24431 arg1Of extracts,Nuclear
R19434 T24432 T24433 arg1Of extracts,were
R19435 T24432 T24434 arg2Of extracts,analysed
R19436 T24434 T24433 arg2Of analysed,were
R19437 T24434 T24435 arg1Of analysed,for
R19438 T24437 T24438 arg1Of p65,","
R19439 T24438 T24440 arg1Of ",",and
R19440 T24439 T24438 arg2Of p50,","
R19441 T24441 T24440 arg2Of FLAG-Tat,and
R19442 T24442 T24435 arg2Of binding,for
R19443 T24442 T24436 arg1Of binding,the
R19444 T24442 T24437 arg1Of binding,p65
R19445 T24442 T24439 arg1Of binding,p50
R19446 T24442 T24441 arg1Of binding,FLAG-Tat
R19447 T24442 T24443 arg1Of binding,to
R19448 T24447 T24443 arg2Of oligonucleotide,to
R19449 T24447 T24444 arg1Of oligonucleotide,the
R19450 T24447 T24445 arg1Of oligonucleotide,NF-κB
R19451 T24447 T24446 arg1Of oligonucleotide,double-stranded
R19452 T24447 T24448 arg1Of oligonucleotide,using
R19453 T24455 T24449 arg1Of kit,the
R19454 T24455 T24450 arg1Of kit,NF-κB
R19455 T24455 T24451 arg1Of kit,Transcription
R19456 T24455 T24452 arg1Of kit,Factor
R19457 T24455 T24453 arg1Of kit,ELISA
R19458 T24455 T24454 arg1Of kit,assay
R19459 T24455 T24456 arg1Of kit,(
R19460 T24455 T24469 modOf kit,20 µ
R19461 T24455 T24480 arg1Of kit,ester
R19462 T24455 T24488 arg1Of kit,F
R19463 T24457 T24456 arg2Of Cayman,(
R19464 T24458 T24456 arg3Of ),(
R19465 T24460 T24459 arg2Of (,.
R19466 T24461 T24459 arg3Of B,.
R19467 T24462 T24463 arg1Of ) Nucle,ar
R19468 T24464 T24463 arg2Of and cytos,ar
R19469 T24465 T24459 arg1Of olic ext,.
R19470 T24465 T24462 arg1Of olic ext,) Nucle
R19471 T24465 T24464 arg1Of olic ext,and cytos
R19472 T24465 T24466 arg1Of olic ext,r
R19473 T24465 T24469 arg1Of olic ext,20 µ
R19474 T24465 T24470 arg2Of olic ext,g) were s
R19475 T24465 T24476 arg2Of olic ext,SDS–PAGE
R19476 T24467 T24466 arg2Of acts ,r
R19477 T24468 T24466 arg3Of (,r
R19478 T24470 T24475 arg1Of g) were s,2%
R19479 T24472 T24473 arg1Of ar,a
R19480 T24474 T24470 arg1Of ted by 1,g) were s
R19481 T24474 T24471 arg2Of ted by 1,ep
R19482 T24474 T24472 arg1Of ted by 1,ar
R19483 T24475 T24469 arg2Of 2% ,20 µ
R19484 T24476 T24475 arg2Of SDS–PAGE,2%
R19485 T24479 T24476 arg1Of sed by w,SDS–PAGE
R19486 T24479 T24477 arg2Of sed by w,an
R19487 T24479 T24478 arg1Of sed by w,d analy
R19488 T24482 T24483 arg1Of lotting ,u
R19489 T24483 T24485 arg1Of u,a
R19490 T24484 T24483 arg2Of sing the ,u
R19491 T24486 T24485 arg2Of "nti-p65, ant",a
R19492 T24487 T24480 arg2Of i-,ester
R19493 T24487 T24481 arg1Of i-,n b
R19494 T24487 T24482 arg1Of i-,lotting
R19495 T24487 T24484 arg1Of i-,sing the
R19496 T24487 T24486 arg1Of i-,"nti-p65, ant"
R19497 T24488 T24448 arg2Of F,using
R19498 T24489 T24490 arg1Of "LAG, anti-",His
R19499 T24491 T24490 arg2Of "tone H1, anti-IκB-",His
R19500 T24492 T24488 arg2Of α and anti,F
R19501 T24492 T24489 arg1Of α and anti,"LAG, anti-"
R19502 T24492 T24491 arg1Of α and anti,"tone H1, anti-IκB-"
R19503 T24494 T24493 arg1Of values,Densitometry
R19504 T24494 T24495 arg1Of values,(
R19505 T24494 T24498 arg1Of values,of
R19506 T24494 T24501 arg1Of values,were
R19507 T24494 T24502 arg2Of values,expressed
R19508 T24496 T24495 arg2Of D,(
R19509 T24497 T24495 arg3Of ),(
R19510 T24500 T24498 arg2Of bands,of
R19511 T24500 T24499 arg1Of bands,the
R19512 T24502 T24501 arg2Of expressed,were
R19513 T24502 T24503 arg1Of expressed,as
R19514 T24502 T24554 arg1Of expressed,t
R19515 T24505 T24503 arg2Of increase,as
R19516 T24505 T24504 arg1Of increase,fold
R19517 T24505 T24506 arg1Of increase,above
R19518 T24505 T24518 modOf increase,ity
R19519 T24508 T24506 arg2Of control,above
R19520 T24508 T24507 arg1Of control,the
R19521 T24510 T24509 arg2Of lane,(
R19522 T24510 T24511 arg1Of lane,1
R19523 T24512 T24509 arg3Of ),(
R19524 T24514 T24513 arg2Of (,.
R19525 T24515 T24513 arg3Of C,.
R19526 T24517 T24509 arg1Of KK activ,(
R19527 T24517 T24513 arg1Of KK activ,.
R19528 T24517 T24516 arg1Of KK activ,) I
R19529 T24517 T24518 arg1Of KK activ,ity
R19530 T24517 T24519 arg2Of KK activ,was meas
R19531 T24519 T24518 arg2Of was meas,ity
R19532 T24519 T24520 arg1Of was meas,ur
R19533 T24519 T24526 arg1Of was meas,10
R19534 T24522 T24520 arg2Of osolic e,ur
R19535 T24522 T24521 arg1Of osolic e,ed in cyt
R19536 T24522 T24523 arg1Of osolic e,x
R19537 T24524 T24523 arg2Of tracts,x
R19538 T24525 T24523 arg3Of (,x
R19539 T24527 T24526 arg2Of 0 µg),10
R19540 T24531 T24527 arg2Of IKK k,0 µg)
R19541 T24531 T24528 arg1Of IKK k,by usi
R19542 T24531 T24529 arg1Of IKK k,ng
R19543 T24531 T24530 arg1Of IKK k,HTScan
R19544 T24531 T24532 arg1Of IKK k,i
R19545 T24531 T24545 modOf IKK k,cell
R19546 T24535 T24532 arg2Of ll Signali,i
R19547 T24535 T24533 arg1Of ll Signali,nase
R19548 T24535 T24534 arg1Of ll Signali,assay (Ce
R19549 T24536 T24532 arg3Of n,i
R19550 T24538 T24537 arg2Of T,g
R19551 T24539 T24537 arg3Of e,g
R19552 T24541 T24537 arg1Of logy),g
R19553 T24541 T24540 arg1Of logy),chno
R19554 T24541 T24542 arg1Of logy),.
R19555 T24541 T24545 arg1Of logy),cell
R19556 T24541 T24546 arg2Of logy),s (5 × 106)
R19557 T24543 T24542 arg2Of (D) HeL,.
R19558 T24544 T24542 arg3Of a,.
R19559 T24546 T24545 arg2Of s (5 × 106),cell
R19560 T24546 T24547 arg1Of s (5 × 106),were
R19561 T24546 T24549 arg1Of s (5 × 106),ansfect
R19562 T24547 T24548 arg1Of were,tr
R19563 T24549 T24548 arg2Of ansfect,tr
R19564 T24550 T24547 arg2Of ed with or ,were
R19565 T24550 T24549 arg2Of ed with or ,ansfect
R19566 T24550 T24551 arg1Of ed with or ,w
R19567 T24552 T24551 arg2Of itho,w
R19568 T24553 T24551 arg3Of u,w
R19569 T24556 T24555 arg1Of LAG-T,p3xF
R19570 T24558 T24559 arg1Of t (5 ,µg);
R19571 T24558 T24560 arg2Of t (5 ,48 h later
R19572 T24558 T24569 arg1Of t (5 ,h PM
R19573 T24560 T24559 arg2Of 48 h later,µg);
R19574 T24560 T24561 arg1Of 48 h later,", ce"
R19575 T24560 T24568 arg1Of 48 h later,it
R19576 T24562 T24561 arg2Of lls,", ce"
R19577 T24562 T24563 arg1Of lls,w
R19578 T24564 T24563 arg2Of ere s,w
R19579 T24564 T24565 arg1Of ere s,t
R19580 T24566 T24565 arg2Of imulated,t
R19581 T24567 T24563 arg3Of w,w
R19582 T24568 T24554 arg2Of it,t
R19583 T24568 T24556 arg1Of it,LAG-T
R19584 T24568 T24557 arg1Of it,a
R19585 T24569 T24568 arg2Of h PM,it
R19586 T24569 T24571 arg1Of h PM, 
R19587 T24570 T24569 arg2Of "A (5 min, 20",h PM
R19588 T24570 T24572 arg2Of "A (5 min, 20",ng/ml)
R19589 T24570 T24578 arg2Of "A (5 min, 20","ted, wash"
R19590 T24572 T24573 arg1Of ng/ml),or le
R19591 T24572 T24574 arg1Of ng/ml),ft u
R19592 T24572 T24577 arg1Of ng/ml),ula
R19593 T24575 T24574 arg2Of nsti,ft u
R19594 T24577 T24569 arg3Of ula,h PM
R19595 T24577 T24576 arg1Of ula,m
R19596 T24578 T24577 arg2Of "ted, wash",ula
R19597 T24578 T24579 arg1Of "ted, wash",ed tw
R19598 T24580 T24579 arg2Of ice wit,ed tw
R19599 T24583 T24581 arg1Of extracts,Whole
R19600 T24583 T24582 arg1Of extracts,cell
R19601 T24583 T24584 arg1Of extracts,(
R19602 T24583 T24587 arg1Of extracts,were
R19603 T24583 T24588 arg2Of extracts,immunoprecipitated
R19604 T24585 T24584 arg2Of 1 mg,(
R19605 T24586 T24584 arg3Of ),(
R19606 T24588 T24587 arg2Of immunoprecipitated,were
R19607 T24588 T24589 arg1Of immunoprecipitated,with
R19608 T24593 T24589 arg2Of antibody,with
R19609 T24593 T24590 arg1Of antibody,protein
R19610 T24593 T24591 arg1Of antibody,G-Sepharose-coupled
R19611 T24593 T24592 arg1Of antibody,anti-IκB-α
R19612 T24594 T24595 arg1Of Immunocomplexes,were
R19613 T24594 T24596 arg2Of Immunocomplexes,separated
R19614 T24594 T24602 arg2Of Immunocomplexes,analysed
R19615 T24596 T24601 arg1Of separated,and
R19616 T24598 T24599 arg1Of 12,%
R19617 T24600 T24596 arg1Of SDS–PAGE,separated
R19618 T24600 T24597 arg2Of SDS–PAGE,by
R19619 T24600 T24598 arg1Of SDS–PAGE,12
R19620 T24601 T24595 arg2Of and,were
R19621 T24602 T24601 arg2Of analysed,and
R19622 T24605 T24602 arg1Of blotting,analysed
R19623 T24605 T24603 arg2Of blotting,by
R19624 T24605 T24604 arg1Of blotting,western
R19625 T24605 T24606 arg1Of blotting,with
R19626 T24607 T24608 arg1Of anti-p65,","
R19627 T24608 T24610 arg1Of ",",and
R19628 T24609 T24608 arg2Of anti-FLAG,","
R19629 T24611 T24610 arg2Of anti-IκB-α,and
R19630 T24612 T24606 arg2Of antibodies,with
R19631 T24612 T24607 arg1Of antibodies,anti-p65
R19632 T24612 T24609 arg1Of antibodies,anti-FLAG
R19633 T24612 T24611 arg1Of antibodies,anti-IκB-α
R19634 T24614 T24613 arg1Of values,Densitometry
R19635 T24614 T24615 arg1Of values,(
R19636 T24614 T24618 arg1Of values,of
R19637 T24614 T24621 arg1Of values,were
R19638 T24614 T24622 arg2Of values,expressed
R19639 T24616 T24615 arg2Of D,(
R19640 T24617 T24615 arg3Of ),(
R19641 T24620 T24618 arg2Of bands,of
R19642 T24620 T24619 arg1Of bands,the
R19643 T24622 T24621 arg2Of expressed,were
R19644 T24622 T24623 arg1Of expressed,as
R19645 T24625 T24623 arg2Of increase,as
R19646 T24625 T24624 arg1Of increase,fold
R19647 T24625 T24626 arg1Of increase,above
R19648 T24628 T24626 arg2Of control,above
R19649 T24628 T24627 arg1Of control,the
R19650 T24628 T24629 arg1Of control,(
R19651 T24630 T24629 arg2Of lane,(
R19652 T24630 T24631 arg1Of lane,1
R19653 T24632 T24629 arg3Of ),(
R19654 T24633 T24634 arg1Of Values,(
R19655 T24633 T24639 arg1Of Values,are
R19656 T24633 T24640 arg2Of Values,shown
R19657 T24635 T24634 arg2Of mean ± SE,(
R19658 T24635 T24636 arg1Of mean ± SE,","
R19659 T24637 T24636 arg2Of n = 3,","
R19660 T24638 T24634 arg3Of ),(
R19661 T24640 T24639 arg2Of shown,are
R20033 T25214 T25215 arg1Of Tat,relieves
R20034 T25214 T25280 arg1Of Tat,using
R20035 T25215 T25280 modOf relieves,using
R20036 T25216 T25217 arg1Of p65,from
R20037 T25216 T25226 arg1Of p65,of
R20038 T25216 T25263 arg1Of p65,","
R20039 T25222 T25221 arg2Of A,(
R20040 T25223 T25221 arg3Of ),(
R20041 T25225 T25217 arg2Of representation,from
R20042 T25225 T25218 arg1Of representation,the
R20043 T25225 T25219 arg1Of representation,IκB-α
R20044 T25225 T25220 arg1Of representation,inhibition.
R20045 T25225 T25221 arg1Of representation,(
R20046 T25225 T25224 arg1Of representation,Schematic
R20047 T25227 T25228 arg1Of wild-type,and
R20048 T25229 T25228 arg2Of mutant,and
R20049 T25231 T25227 arg1Of proteins.,wild-type
R20050 T25231 T25229 arg1Of proteins.,mutant
R20051 T25231 T25230 arg1Of proteins.,Tat
R20052 T25231 T25232 arg1Of proteins.,(
R20053 T25231 T25239 modOf proteins.,was
R20054 T25231 T25243 arg1Of proteins.,or
R20055 T25233 T25232 arg2Of B,(
R20056 T25234 T25232 arg3Of ),(
R20057 T25235 T25236 arg1Of HA-IκB-α,(
R20058 T25235 T25239 arg1Of HA-IκB-α,was
R20059 T25235 T25240 arg2Of HA-IκB-α,incubated
R20060 T25237 T25236 arg2Of 5 µl,(
R20061 T25238 T25236 arg3Of ),(
R20062 T25240 T25239 arg2Of incubated,was
R20063 T25240 T25241 arg1Of incubated,in
R20064 T25242 T25241 arg2Of presence,in
R20065 T25243 T25226 arg2Of or,of
R20066 T25244 T25245 arg1Of absence,of
R20067 T25244 T25256 arg1Of absence,","
R20068 T25246 T25245 arg2Of FLAG-Tat,of
R20069 T25246 T25247 arg1Of FLAG-Tat,","
R20070 T25246 T25250 arg1Of FLAG-Tat,","
R20071 T25249 T25247 arg2Of T,","
R20072 T25249 T25248 arg1Of T,FLAG-Tat
R20073 T25253 T25252 arg2Of "23,24",(
R20074 T25254 T25252 arg3Of ),(
R20075 T25255 T25250 arg2Of A,","
R20076 T25255 T25251 arg1Of A,N
R20077 T25255 T25252 arg1Of A,(
R20078 T25256 T25243 arg2Of ",",or
R20079 T25260 T25259 arg2Of "50,51",(
R20080 T25261 T25259 arg3Of ),(
R20081 T25262 T25256 arg2Of A,","
R20082 T25262 T25257 arg1Of A,FLAG-Tat
R20083 T25262 T25258 arg1Of A,K
R20084 T25262 T25259 arg1Of A,(
R20085 T25263 T25270 arg1Of ",",or
R20086 T25265 T25264 arg1Of R,FLAG-Tat
R20087 T25265 T25266 arg1Of R,(
R20088 T25267 T25266 arg2Of 49–57,(
R20089 T25268 T25266 arg3Of ),(
R20090 T25269 T25263 arg2Of A,","
R20091 T25269 T25265 arg1Of A,R
R20092 T25270 T25215 arg2Of or,relieves
R20093 T25274 T25273 arg2Of "22,25,27",(
R20094 T25275 T25273 arg3Of ),(
R20095 T25276 T25270 arg2Of A,or
R20096 T25276 T25271 arg1Of A,FLAG-Tat
R20097 T25276 T25272 arg1Of A,C
R20098 T25276 T25273 arg1Of A,(
R20099 T25276 T25277 arg1Of A,(
R20100 T25278 T25277 arg2Of 10 µl,(
R20101 T25279 T25277 arg3Of ),(
R20102 T25284 T25280 arg2Of proteins,using
R20103 T25284 T25281 arg1Of proteins,in
R20104 T25284 T25282 arg1Of proteins,vitro
R20105 T25284 T25283 arg2Of proteins,translated
R20106 T25285 T25286 arg1Of Wild-type,and
R20107 T25287 T25286 arg2Of mutant,and
R20108 T25289 T25285 arg1Of proteins,Wild-type
R20109 T25289 T25287 arg1Of proteins,mutant
R20110 T25289 T25288 arg1Of proteins,Tat
R20111 T25289 T25290 arg1Of proteins,were
R20112 T25289 T25291 arg2Of proteins,immunoprecipitated
R20113 T25291 T25290 arg2Of immunoprecipitated,were
R20114 T25291 T25292 arg1Of immunoprecipitated,with
R20115 T25291 T25295 arg1Of immunoprecipitated,;
R20116 T25294 T25292 arg2Of antibody,with
R20117 T25294 T25293 arg1Of antibody,anti-FLAG
R20118 T25296 T25297 arg1Of immunocomplexes,were
R20119 T25296 T25298 arg2Of immunocomplexes,separated
R20120 T25296 T25304 arg2Of immunocomplexes,analysed
R20121 T25298 T25303 arg1Of separated,and
R20122 T25300 T25301 arg1Of 12,%
R20123 T25302 T25298 arg1Of SDS–PAGE,separated
R20124 T25302 T25299 arg2Of SDS–PAGE,by
R20125 T25302 T25300 arg1Of SDS–PAGE,12
R20126 T25303 T25295 arg2Of and,;
R20127 T25303 T25297 arg2Of and,were
R20128 T25303 T25308 arg1Of and,with
R20129 T25304 T25303 arg2Of analysed,and
R20130 T25307 T25304 arg1Of blotting,analysed
R20131 T25307 T25305 arg2Of blotting,by
R20132 T25307 T25306 arg1Of blotting,western
R20133 T25309 T25310 arg1Of anti-HA,and
R20134 T25311 T25310 arg2Of anti-FLAG,and
R20135 T25312 T25308 arg2Of antibodies.,with
R20136 T25312 T25309 arg1Of antibodies.,anti-HA
R20137 T25312 T25311 arg1Of antibodies.,anti-FLAG
R20138 T25312 T25313 arg1Of antibodies.,(
R20139 T25312 T25321 modOf antibodies.,was
R20140 T25314 T25313 arg2Of C,(
R20141 T25315 T25313 arg3Of ),(
R20142 T25317 T25316 arg1Of p65,35S-methionine-labeled
R20143 T25317 T25318 arg1Of p65,(
R20144 T25317 T25321 arg1Of p65,was
R20145 T25317 T25322 arg2Of p65,incubated
R20146 T25319 T25318 arg2Of 5 µl,(
R20147 T25320 T25318 arg3Of ),(
R20148 T25322 T25321 arg2Of incubated,was
R20149 T25322 T25323 arg1Of incubated,with
R20150 T25325 T25324 arg1Of vitro,in
R20151 T25327 T25323 arg2Of HA-IκB-α,with
R20152 T25327 T25325 arg1Of HA-IκB-α,vitro
R20153 T25327 T25326 arg2Of HA-IκB-α,translated
R20154 T25327 T25328 arg1Of HA-IκB-α,(
R20155 T25327 T25331 arg1Of HA-IκB-α,in
R20156 T25327 T25335 arg1Of HA-IκB-α,of
R20157 T25329 T25328 arg2Of 5 µl,(
R20158 T25330 T25328 arg3Of ),(
R20159 T25332 T25333 arg1Of presence,or
R20160 T25333 T25331 arg2Of or,in
R20161 T25334 T25333 arg2Of absence,or
R20162 T25336 T25337 arg1Of FLAG-Tat,or
R20163 T25339 T25337 arg2Of R,or
R20164 T25339 T25338 arg1Of R,FLAG-Tat
R20165 T25339 T25340 arg1Of R,(
R20166 T25341 T25340 arg2Of 49–57,(
R20167 T25342 T25340 arg3Of ),(
R20168 T25343 T25335 arg2Of A,of
R20169 T25343 T25336 arg1Of A,FLAG-Tat
R20170 T25343 T25339 arg1Of A,R
R20171 T25343 T25344 arg1Of A,(
R20172 T25345 T25346 arg1Of 5,","
R20173 T25346 T25348 arg1Of ",",or
R20174 T25347 T25346 arg2Of 10,","
R20175 T25348 T25344 arg2Of or,(
R20176 T25349 T25348 arg2Of 20 µl,or
R20177 T25350 T25344 arg3Of ),(
R20178 T25351 T25352 arg1Of HA-IκB-α,was
R20179 T25351 T25353 arg2Of HA-IκB-α,immunoprecipitated
R20180 T25353 T25352 arg2Of immunoprecipitated,was
R20181 T25353 T25354 arg1Of immunoprecipitated,with
R20182 T25353 T25357 arg1Of immunoprecipitated,;
R20183 T25356 T25354 arg2Of antibody,with
R20184 T25356 T25355 arg1Of antibody,anti-HA
R20185 T25358 T25359 arg1Of immunocomplexes,were
R20186 T25358 T25360 arg2Of immunocomplexes,separated
R20187 T25358 T25366 arg2Of immunocomplexes,analysed
R20188 T25360 T25365 arg1Of separated,and
R20189 T25362 T25363 arg1Of 12,%
R20190 T25364 T25360 arg1Of SDS–PAGE,separated
R20191 T25364 T25361 arg2Of SDS–PAGE,by
R20192 T25364 T25362 arg1Of SDS–PAGE,12
R20193 T25365 T25357 arg2Of and,;
R20194 T25365 T25359 arg2Of and,were
R20195 T25366 T25365 arg2Of analysed,and
R20196 T25369 T25368 arg1Of blotting,western
R20197 T25369 T25370 arg1Of blotting,with
R20198 T25369 T25376 arg1Of blotting,or
R20199 T25371 T25372 arg1Of anti-HA,and
R20200 T25373 T25372 arg2Of anti-FLAG,and
R20201 T25374 T25370 arg2Of antibodies,with
R20202 T25374 T25371 arg1Of antibodies,anti-HA
R20203 T25374 T25373 arg1Of antibodies,anti-FLAG
R20204 T25376 T25366 arg1Of or,analysed
R20205 T25376 T25367 arg2Of or,by
R20206 T25376 T25375 arg1Of or,","
R20207 T25377 T25376 arg2Of autoradiography,or
R20208 T25377 T25378 arg1Of autoradiography,(
R20209 T25379 T25378 arg2Of 35S-Met-p65,(
R20210 T25380 T25378 arg3Of ),(
R20211 T25382 T25381 arg1Of values,Densitometry
R20212 T25382 T25383 arg1Of values,(
R20213 T25382 T25386 arg1Of values,of
R20214 T25382 T25389 arg1Of values,were
R20215 T25382 T25390 arg2Of values,expressed
R20216 T25384 T25383 arg2Of D,(
R20217 T25385 T25383 arg3Of ),(
R20218 T25388 T25386 arg2Of bands,of
R20219 T25388 T25387 arg1Of bands,the
R20220 T25390 T25389 arg2Of expressed,were
R20221 T25390 T25391 arg1Of expressed,as
R20222 T25393 T25391 arg2Of increase,as
R20223 T25393 T25392 arg1Of increase,fold
R20224 T25393 T25394 arg1Of increase,above
R20225 T25393 T25401 arg1Of increase,.
R20226 T25396 T25394 arg2Of control,above
R20227 T25396 T25395 arg1Of control,the
R20228 T25396 T25397 arg1Of control,(
R20229 T25398 T25397 arg2Of lane,(
R20230 T25398 T25399 arg1Of lane,1
R20231 T25400 T25397 arg3Of ),(
R20232 T25402 T25401 arg2Of (,.
R20233 T25403 T25401 arg3Of D,.
R20234 T25408 T25404 arg1Of ding act,) T
R20235 T25408 T25405 arg1Of ding act,he
R20236 T25408 T25406 arg1Of ding act,p65
R20237 T25408 T25407 arg1Of ding act,DNA bin
R20238 T25408 T25409 arg1Of ding act,ivi
R20239 T25408 T25410 arg2Of ding act,ty was a
R20240 T25410 T25389 modOf ty was a,were
R20241 T25410 T25409 arg2Of ty was a,ivi
R20242 T25412 T25410 arg1Of lyse,ty was a
R20243 T25412 T25411 arg2Of lyse,na
R20244 T25412 T25413 arg1Of lyse,d by
R20245 T25415 T25414 arg1Of SA us,EM
R20246 T25417 T25413 arg2Of ro trans,d by
R20247 T25417 T25415 arg1Of ro trans,SA us
R20248 T25417 T25416 arg2Of ro trans,ing in vit
R20249 T25420 T25418 arg1Of oligonucleotide,32P-labeled-NF-κB
R20250 T25420 T25419 arg1Of oligonucleotide,double-stranded
R20251 T25420 T25421 arg1Of oligonucleotide,was
R20252 T25420 T25422 arg2Of oligonucleotide,incubated
R20253 T25422 T25421 arg2Of incubated,was
R20254 T25422 T25423 arg1Of incubated,with
R20255 T25422 T25451 arg1Of incubated,;
R20256 T25424 T25423 arg2Of p65,with
R20257 T25424 T25425 arg1Of p65,(
R20258 T25424 T25428 arg1Of p65,in
R20259 T25424 T25432 arg1Of p65,of
R20260 T25426 T25425 arg2Of 0.5 µl,(
R20261 T25427 T25425 arg3Of ),(
R20262 T25429 T25430 arg1Of presence,or
R20263 T25430 T25428 arg2Of or,in
R20264 T25431 T25430 arg2Of absence,or
R20265 T25433 T25434 arg1Of HA-IκB-α,(
R20266 T25433 T25437 arg1Of HA-IκB-α,","
R20267 T25435 T25434 arg2Of 1 µl,(
R20268 T25436 T25434 arg3Of ),(
R20269 T25437 T25439 arg1Of ",",or
R20270 T25438 T25437 arg2Of FLAG-Tat,","
R20271 T25439 T25432 arg2Of or,of
R20272 T25441 T25440 arg1Of R,FLAG-Tat
R20273 T25441 T25442 arg1Of R,(
R20274 T25443 T25442 arg2Of 49–57,(
R20275 T25444 T25442 arg3Of ),(
R20276 T25445 T25439 arg2Of A,or
R20277 T25445 T25441 arg1Of A,R
R20278 T25445 T25446 arg1Of A,(
R20279 T25447 T25448 arg1Of 5,and
R20280 T25448 T25446 arg2Of and,(
R20281 T25449 T25448 arg2Of 10 µl,and
R20282 T25450 T25446 arg3Of ),(
R20283 T25452 T25453 arg1Of competition,of
R20284 T25452 T25456 arg1Of competition,was
R20285 T25452 T25457 arg2Of competition,performed
R20286 T25455 T25453 arg2Of binding,of
R20287 T25455 T25454 arg1Of binding,DNA
R20288 T25457 T25451 arg2Of performed,;
R20289 T25457 T25456 arg2Of performed,was
R20290 T25457 T25458 arg1Of performed,with
R20291 T25461 T25460 arg1Of to,up
R20292 T25464 T25458 arg2Of excess,with
R20293 T25464 T25459 arg1Of excess,10 -
R20294 T25464 T25461 arg1Of excess,to
R20295 T25464 T25462 arg1Of excess,100-fold
R20296 T25464 T25463 arg1Of excess,molar
R20297 T25464 T25465 arg1Of excess,of
R20298 T25469 T25465 arg2Of oligonucleotide,of
R20299 T25469 T25466 arg1Of oligonucleotide,unlabeled
R20300 T25469 T25467 arg1Of oligonucleotide,NF-κB
R20301 T25469 T25468 arg1Of oligonucleotide,double-stranded
R20302 T25471 T25470 arg1Of complexes,DNA/protein
R20303 T25471 T25472 arg1Of complexes,were
R20304 T25471 T25473 arg2Of complexes,run
R20305 T25471 T25479 arg2Of complexes,analysed
R20306 T25473 T25474 arg1Of run,on
R20307 T25473 T25478 arg1Of run,and
R20308 T25475 T25476 arg1Of 6,%
R20309 T25477 T25474 arg2Of PAGE–TBE,on
R20310 T25477 T25475 arg1Of PAGE–TBE,6
R20311 T25478 T25472 arg2Of and,were
R20312 T25479 T25478 arg2Of analysed,and
R20313 T25481 T25479 arg1Of autoradiography.,analysed
R20314 T25481 T25480 arg2Of autoradiography.,by
R20315 T25481 T25482 arg1Of autoradiography.,(
R20316 T25481 T25490 modOf autoradiography.,were
R20317 T25483 T25482 arg2Of E,(
R20318 T25484 T25482 arg3Of ),(
R20319 T25485 T25486 arg1Of p50−/−p65−/−MEFs,(
R20320 T25485 T25490 arg1Of p50−/−p65−/−MEFs,were
R20321 T25485 T25491 arg2Of p50−/−p65−/−MEFs,transfected
R20322 T25488 T25486 arg2Of cells,(
R20323 T25488 T25487 arg1Of cells,3 × 105
R20324 T25489 T25486 arg3Of ),(
R20325 T25491 T25490 arg2Of transfected,were
R20326 T25491 T25492 arg1Of transfected,with
R20327 T25493 T25494 arg1Of pκBLuc,(
R20328 T25493 T25497 arg1Of pκBLuc,and
R20329 T25495 T25494 arg2Of 0.5 µg,(
R20330 T25496 T25494 arg3Of ),(
R20331 T25497 T25492 arg2Of and,with
R20332 T25498 T25499 arg1Of pSV-β-Gal,(
R20333 T25498 T25502 arg1Of pSV-β-Gal,with
R20334 T25498 T25504 arg1Of pSV-β-Gal,without
R20335 T25500 T25499 arg2Of 0.1 µg,(
R20336 T25501 T25499 arg3Of ),(
R20337 T25502 T25503 arg1Of with,or
R20338 T25504 T25503 arg2Of without,or
R20339 T25505 T25506 arg1Of pRc/CMV-p65,(
R20340 T25505 T25509 arg1Of pRc/CMV-p65,","
R20341 T25507 T25506 arg2Of 0.5 µg,(
R20342 T25508 T25506 arg3Of ),(
R20343 T25509 T25514 arg1Of ",",","
R20344 T25510 T25509 arg2Of pCMV4-HA-IκB-α,","
R20345 T25510 T25511 arg1Of pCMV4-HA-IκB-α,(
R20346 T25512 T25511 arg2Of 0.5 µg,(
R20347 T25513 T25511 arg3Of ),(
R20348 T25514 T25516 arg1Of ",",or
R20349 T25515 T25514 arg2Of p3xFLAG-Tat,","
R20350 T25516 T25502 arg2Of or,with
R20351 T25516 T25504 arg2Of or,without
R20352 T25518 T25516 arg2Of R,or
R20353 T25518 T25517 arg1Of R,p3xFLAG-Tat
R20354 T25518 T25519 arg1Of R,(
R20355 T25520 T25519 arg2Of 49–57,(
R20356 T25521 T25519 arg3Of ),(
R20357 T25522 T25497 arg2Of A,and
R20358 T25522 T25498 arg1Of A,pSV-β-Gal
R20359 T25522 T25523 arg1Of A,(
R20360 T25524 T25525 arg1Of 0.5,","
R20361 T25525 T25527 arg1Of ",",and
R20362 T25526 T25525 arg2Of 1,","
R20363 T25527 T25523 arg2Of and,(
R20364 T25528 T25527 arg2Of 2 µg,and
R20365 T25529 T25523 arg3Of ),(
R20366 T25532 T25530 arg1Of activity,The
R20367 T25532 T25531 arg1Of activity,luciferase
R20368 T25532 T25533 arg1Of activity,was
R20369 T25532 T25534 arg2Of activity,measured
R20370 T25532 T25541 arg2Of activity,normalized
R20371 T25534 T25535 arg1Of measured,in
R20372 T25534 T25540 arg1Of measured,and
R20373 T25537 T25535 arg2Of extracts,in
R20374 T25537 T25536 arg1Of extracts,cell
R20375 T25537 T25539 arg1Of extracts,post-transfection
R20376 T25539 T25538 arg1Of post-transfection,48-h
R20377 T25540 T25533 arg2Of and,was
R20378 T25541 T25540 arg2Of normalized,and
R20379 T25541 T25542 arg1Of normalized,to
R20380 T25544 T25542 arg2Of activity,to
R20381 T25544 T25543 arg1Of activity,β-galactosidase
R20382 T25546 T25545 arg1Of activation,Fold
R20383 T25546 T25547 arg1Of activation,was
R20384 T25546 T25548 arg2Of activation,calculated
R20385 T25548 T25547 arg2Of calculated,was
R20386 T25548 T25550 arg1Of calculated,to
R20387 T25550 T25549 arg1Of to,relative
R20388 T25551 T25550 arg2Of transfection,to
R20389 T25551 T25552 arg1Of transfection,of
R20390 T25555 T25552 arg2Of plasmid,of
R20391 T25555 T25553 arg1Of plasmid,the
R20392 T25555 T25554 arg1Of plasmid,pκBLuc
R20393 T25555 T25556 arg1Of plasmid,alone
R20394 T25557 T25558 arg1Of Values,(
R20395 T25557 T25563 arg1Of Values,are
R20396 T25557 T25564 arg2Of Values,shown
R20397 T25559 T25558 arg2Of mean ± SE,(
R20398 T25559 T25560 arg1Of mean ± SE,","
R20399 T25561 T25560 arg2Of n = 3,","
R20400 T25562 T25558 arg3Of ),(
R20401 T25564 T25563 arg2Of shown,are
R20402 T25566 T25565 arg2Of control,As
R20403 T25566 T25567 arg1Of control,of
R20404 T25569 T25567 arg2Of expression,of
R20405 T25569 T25568 arg1Of expression,protein
R20406 T25571 T25572 arg1Of aliquots,of
R20407 T25571 T25578 arg1Of aliquots,were
R20408 T25571 T25579 arg2Of aliquots,analysed
R20409 T25574 T25572 arg2Of extracts,of
R20410 T25574 T25573 arg1Of extracts,cell
R20411 T25574 T25575 arg1Of extracts,(
R20412 T25576 T25575 arg2Of 20 µg,(
R20413 T25577 T25575 arg3Of ),(
R20414 T25579 T25565 arg1Of analysed,As
R20415 T25579 T25570 arg1Of analysed,","
R20416 T25579 T25578 arg2Of analysed,were
R20417 T25582 T25579 arg1Of blotting,analysed
R20418 T25582 T25580 arg2Of blotting,by
R20419 T25582 T25581 arg1Of blotting,western
R20420 T25582 T25583 arg1Of blotting,with
R20421 T25584 T25585 arg1Of anti-p65,","
R20422 T25585 T25587 arg1Of ",",","
R20423 T25586 T25585 arg2Of anti-HA,","
R20424 T25587 T25589 arg1Of ",",and
R20425 T25588 T25587 arg2Of anti-FLAG,","
R20426 T25590 T25589 arg2Of anti-γ-tubulin,and
R20427 T25591 T25583 arg2Of antibodies,with
R20428 T25591 T25584 arg1Of antibodies,anti-p65
R20429 T25591 T25586 arg1Of antibodies,anti-HA
R20430 T25591 T25588 arg1Of antibodies,anti-FLAG
R20431 T25591 T25590 arg1Of antibodies,anti-γ-tubulin
R21360 T27266 T27280 arg1Of Tat,promoting
R21368 T27275 T27279 arg1Of occupying,and
R21369 T27278 T27275 arg2Of enhancers,occupying
R21370 T27278 T27276 arg1Of enhancers,the
R21371 T27278 T27277 arg1Of enhancers,NF-κB
R21373 T27280 T27279 arg2Of promoting,and
R21374 T27283 T27280 arg2Of recruitment,promoting
R21375 T27283 T27281 arg1Of recruitment,the
R21376 T27283 T27282 arg1Of recruitment,p65
R21377 T27283 T27284 arg1Of recruitment,with
R21378 T27286 T27284 arg2Of displacement,with
R21379 T27286 T27285 arg1Of displacement,IκB-α
R21380 T27288 T27287 arg1Of cells,HeLa
R21381 T27288 T27289 arg1Of cells,(
R21382 T27288 T27292 arg1Of cells,were
R21383 T27288 T27293 arg2Of cells,transfected
R21384 T27290 T27289 arg2Of 5 × 106,(
R21385 T27291 T27289 arg3Of ),(
R21386 T27293 T27292 arg2Of transfected,were
R21387 T27293 T27294 arg1Of transfected,with
R21388 T27293 T27314 arg1Of transfected,;
R21389 T27295 T27296 arg1Of p3xFLAG-Tat,","
R21390 T27296 T27302 arg1Of ",",","
R21391 T27298 T27296 arg2Of C,","
R21392 T27298 T27297 arg1Of C,p3xFLAG-Tat
R21393 T27298 T27299 arg1Of C,(
R21394 T27300 T27299 arg2Of "22,25,27",(
R21395 T27301 T27299 arg3Of ),(
R21396 T27302 T27308 arg1Of ",",or
R21397 T27304 T27302 arg2Of R,","
R21398 T27304 T27303 arg1Of R,p3xFLAG-Tat
R21399 T27304 T27305 arg1Of R,(
R21400 T27306 T27305 arg2Of 49–57,(
R21401 T27307 T27305 arg3Of ),(
R21402 T27308 T27294 arg2Of or,with
R21403 T27310 T27308 arg2Of vector,or
R21404 T27310 T27309 arg1Of vector,empty
R21405 T27310 T27311 arg1Of vector,(
R21406 T27312 T27311 arg2Of 10 µg,(
R21407 T27313 T27311 arg3Of ),(
R21408 T27318 T27315 arg2Of interference,for
R21409 T27318 T27316 arg1Of interference,p65
R21410 T27318 T27317 arg1Of interference,RNA
R21411 T27320 T27321 arg1Of cells,(
R21412 T27320 T27324 arg1Of cells,were
R21413 T27320 T27325 arg2Of cells,transfected
R21414 T27322 T27321 arg2Of 5 × 106,(
R21415 T27323 T27321 arg3Of ),(
R21416 T27325 T27314 arg2Of transfected,;
R21417 T27325 T27315 arg1Of transfected,for
R21418 T27325 T27319 arg1Of transfected,","
R21419 T27325 T27324 arg2Of transfected,were
R21420 T27325 T27326 arg1Of transfected,with
R21421 T27327 T27328 arg1Of p3xFLAG-Tat,(
R21422 T27327 T27331 arg1Of p3xFLAG-Tat,and
R21423 T27329 T27328 arg2Of 10 µg,(
R21424 T27330 T27328 arg3Of ),(
R21425 T27331 T27334 arg1Of and,or
R21426 T27333 T27331 arg2Of p65,and
R21427 T27333 T27332 arg1Of p65,siRNA
R21428 T27334 T27326 arg2Of or,with
R21429 T27336 T27334 arg2Of control,or
R21430 T27336 T27335 arg1Of control,siRNA
R21431 T27336 T27337 arg1Of control,(
R21432 T27338 T27337 arg2Of 200 pmol,(
R21433 T27339 T27337 arg3Of ),(
R21434 T27341 T27342 arg1Of post-transfection,","
R21435 T27343 T27342 arg2Of total,","
R21436 T27344 T27340 arg1Of RNA,Twenty-four-hour
R21437 T27344 T27341 arg1Of RNA,post-transfection
R21438 T27344 T27343 arg1Of RNA,total
R21439 T27344 T27345 arg1Of RNA,was
R21440 T27344 T27346 arg2Of RNA,extracted
R21441 T27344 T27348 arg2Of RNA,analysed
R21442 T27346 T27347 arg1Of extracted,and
R21443 T27347 T27345 arg2Of and,was
R21444 T27347 T27352 modOf and,to
R21445 T27348 T27347 arg2Of analysed,and
R21446 T27351 T27346 arg1Of PCR,extracted
R21447 T27351 T27348 arg1Of PCR,analysed
R21448 T27351 T27349 arg2Of PCR,by
R21449 T27351 T27350 arg1Of PCR,real-time
R21450 T27353 T27352 arg1Of evaluate,to
R21451 T27355 T27354 arg1Of expression,the
R21452 T27355 T27356 arg1Of expression,of
R21453 T27355 T27415 arg1Of expression,was
R21454 T27355 T27416 arg2Of expression,performed
R21455 T27357 T27358 arg1Of MIP-1α,(
R21456 T27357 T27361 arg1Of MIP-1α,","
R21457 T27359 T27358 arg2Of A,(
R21458 T27360 T27358 arg3Of ),(
R21459 T27361 T27366 arg1Of ",",","
R21460 T27362 T27361 arg2Of CSF3,","
R21461 T27362 T27363 arg1Of CSF3,(
R21462 T27364 T27363 arg2Of B,(
R21463 T27365 T27363 arg3Of ),(
R21464 T27366 T27371 arg1Of ",",","
R21465 T27367 T27366 arg2Of LTA,","
R21466 T27367 T27368 arg1Of LTA,(
R21467 T27369 T27368 arg2Of C,(
R21468 T27370 T27368 arg3Of ),(
R21469 T27371 T27356 arg2Of ",",of
R21470 T27372 T27373 arg1Of NFKBIA,(
R21471 T27372 T27376 arg1Of NFKBIA,","
R21472 T27374 T27373 arg2Of D,(
R21473 T27375 T27373 arg3Of ),(
R21474 T27376 T27381 arg1Of ",",","
R21475 T27377 T27376 arg2Of TLR2,","
R21476 T27377 T27378 arg1Of TLR2,(
R21477 T27379 T27378 arg2Of E,(
R21478 T27380 T27378 arg3Of ),(
R21479 T27381 T27386 arg1Of ",",","
R21480 T27382 T27381 arg2Of GAPDH,","
R21481 T27382 T27383 arg1Of GAPDH,(
R21482 T27384 T27383 arg2Of F,(
R21483 T27385 T27383 arg3Of ),(
R21484 T27386 T27371 arg2Of ",",","
R21485 T27386 T27400 modOf ",",were
R21486 T27387 T27386 arg2Of ACTB,","
R21487 T27387 T27388 arg1Of ACTB,(
R21488 T27389 T27388 arg2Of G,(
R21489 T27390 T27388 arg3Of ),(
R21490 T27393 T27392 arg2Of H,(
R21491 T27394 T27392 arg3Of ),(
R21492 T27396 T27391 arg1Of cells,genes.
R21493 T27396 T27392 arg1Of cells,(
R21494 T27396 T27395 arg1Of cells,HeLa
R21495 T27396 T27397 arg1Of cells,(
R21496 T27396 T27400 arg1Of cells,were
R21497 T27396 T27401 arg2Of cells,transfected
R21498 T27398 T27397 arg2Of 5 × 106,(
R21499 T27399 T27397 arg3Of ),(
R21500 T27401 T27400 arg2Of transfected,were
R21501 T27401 T27402 arg1Of transfected,with
R21502 T27403 T27405 arg1Of p3xFLAG-Tat,or
R21503 T27405 T27402 arg2Of or,with
R21504 T27405 T27404 arg1Of or,","
R21505 T27407 T27406 arg1Of vector,empty
R21506 T27407 T27408 arg1Of vector,(
R21507 T27407 T27411 arg1Of vector,and
R21508 T27409 T27408 arg2Of 10 µg,(
R21509 T27410 T27408 arg3Of ),(
R21510 T27411 T27405 arg2Of and,or
R21511 T27414 T27411 arg2Of ChIP,and
R21512 T27414 T27412 arg1Of ChIP,48 h
R21513 T27414 T27413 arg1Of ChIP,later
R21514 T27416 T27353 arg2Of performed,evaluate
R21515 T27416 T27415 arg2Of performed,was
R21516 T27416 T27417 arg1Of performed,with
R21517 T27419 T27417 arg2Of antibody,with
R21518 T27419 T27418 arg1Of antibody,anti-p65
R21519 T27421 T27420 arg1Of PCR,Real-time
R21520 T27421 T27422 arg1Of PCR,was
R21521 T27421 T27423 arg2Of PCR,performed
R21522 T27423 T27422 arg2Of performed,was
R21523 T27423 T27424 arg1Of performed,with
R21524 T27423 T27464 arg1Of performed,;
R21525 T27425 T27424 arg2Of primers,with
R21526 T27425 T27426 arg1Of primers,specific
R21527 T27425 T27439 modOf primers,were
R21528 T27426 T27427 arg1Of specific,for
R21529 T27430 T27427 arg2Of promoters.,for
R21530 T27430 T27428 arg1Of promoters.,the
R21531 T27430 T27429 arg2Of promoters.,indicated
R21532 T27432 T27431 arg2Of I,(
R21533 T27433 T27431 arg3Of ),(
R21534 T27435 T27431 arg1Of cells,(
R21535 T27435 T27434 arg1Of cells,HeLa
R21536 T27435 T27436 arg1Of cells,(
R21537 T27435 T27439 arg1Of cells,were
R21538 T27435 T27440 arg2Of cells,transfected
R21539 T27437 T27436 arg2Of 5 × 106,(
R21540 T27438 T27436 arg3Of ),(
R21541 T27440 T27439 arg2Of transfected,were
R21542 T27440 T27441 arg1Of transfected,with
R21543 T27443 T27442 arg1Of vector,empty
R21544 T27443 T27445 arg1Of vector,or
R21545 T27445 T27444 arg1Of or,","
R21546 T27445 T27458 arg1Of or,or
R21547 T27446 T27445 arg2Of p3xFLAG-Tat,or
R21548 T27446 T27447 arg1Of p3xFLAG-Tat,(
R21549 T27446 T27450 arg1Of p3xFLAG-Tat,in
R21550 T27448 T27447 arg2Of 10 µg,(
R21551 T27449 T27447 arg3Of ),(
R21552 T27451 T27452 arg1Of presence,or
R21553 T27452 T27450 arg2Of or,in
R21554 T27452 T27454 arg1Of or,of
R21555 T27453 T27452 arg2Of absence,or
R21556 T27456 T27454 arg2Of p65,of
R21557 T27456 T27455 arg1Of p65,siRNA
R21558 T27458 T27441 arg2Of or,with
R21559 T27458 T27457 arg1Of or,","
R21560 T27460 T27458 arg2Of control,or
R21561 T27460 T27459 arg1Of control,siRNA
R21562 T27460 T27461 arg1Of control,(
R21563 T27462 T27461 arg2Of 200 pmol,(
R21564 T27463 T27461 arg3Of ),(
R21565 T27466 T27465 arg1Of later,48 h
R21566 T27468 T27469 arg1Of ChIP,was
R21567 T27468 T27470 arg2Of ChIP,performed
R21568 T27470 T27464 arg2Of performed,;
R21569 T27470 T27466 arg1Of performed,later
R21570 T27470 T27467 arg1Of performed,","
R21571 T27470 T27469 arg2Of performed,was
R21572 T27470 T27471 arg1Of performed,with
R21573 T27473 T27471 arg2Of antibody,with
R21574 T27473 T27472 arg1Of antibody,anti-FLAG
R21575 T27475 T27474 arg1Of PCR,Real-time
R21576 T27475 T27476 arg1Of PCR,was
R21577 T27475 T27477 arg2Of PCR,performed
R21578 T27477 T27476 arg2Of performed,was
R21579 T27477 T27478 arg1Of performed,with
R21580 T27479 T27478 arg2Of primers,with
R21581 T27479 T27480 arg1Of primers,specific
R21582 T27480 T27481 arg1Of specific,for
R21583 T27484 T27481 arg2Of promoters.,for
R21584 T27484 T27482 arg1Of promoters.,the
R21585 T27484 T27483 arg2Of promoters.,indicated
R21586 T27484 T27485 arg1Of promoters.,(
R21587 T27486 T27485 arg2Of J,(
R21588 T27487 T27485 arg3Of ),(
R21589 T27489 T27488 arg1Of cells,HeLa
R21590 T27489 T27490 arg1Of cells,(
R21591 T27489 T27493 arg1Of cells,were
R21592 T27489 T27494 arg2Of cells,transfected
R21593 T27491 T27490 arg2Of 5 × 106,(
R21594 T27492 T27490 arg3Of ),(
R21595 T27494 T27476 modOf transfected,was
R21596 T27494 T27493 arg2Of transfected,were
R21597 T27494 T27495 arg1Of transfected,with
R21598 T27494 T27516 arg1Of transfected,;
R21599 T27497 T27496 arg1Of vector,empty
R21600 T27497 T27498 arg1Of vector,","
R21601 T27498 T27504 arg1Of ",",or
R21602 T27499 T27498 arg2Of p3xFLAG-Tat,","
R21603 T27499 T27500 arg1Of p3xFLAG-Tat,(
R21604 T27501 T27500 arg2Of 10 µg,(
R21605 T27502 T27500 arg3Of ),(
R21606 T27504 T27503 arg1Of or,","
R21607 T27504 T27510 arg1Of or,or
R21608 T27506 T27505 arg1Of vector,empty
R21609 T27506 T27507 arg1Of vector,plus
R21610 T27507 T27504 arg2Of plus,or
R21611 T27509 T27507 arg2Of IκB-α,plus
R21612 T27509 T27508 arg1Of IκB-α,siRNA
R21613 T27510 T27495 arg2Of or,with
R21614 T27512 T27510 arg2Of control,or
R21615 T27512 T27511 arg1Of control,siRNA
R21616 T27512 T27513 arg1Of control,(
R21617 T27514 T27513 arg2Of 200 pmol,(
R21618 T27515 T27513 arg3Of ),(
R21619 T27518 T27517 arg1Of later,48 h
R21620 T27520 T27521 arg1Of ChIP,was
R21621 T27520 T27522 arg2Of ChIP,performed
R21622 T27522 T27516 arg2Of performed,;
R21623 T27522 T27518 arg1Of performed,later
R21624 T27522 T27519 arg1Of performed,","
R21625 T27522 T27521 arg2Of performed,was
R21626 T27522 T27523 arg1Of performed,with
R21627 T27525 T27523 arg2Of antibody,with
R21628 T27525 T27524 arg1Of antibody,anti-IκB-α
R21629 T27527 T27526 arg1Of PCR,Real-time
R21630 T27527 T27528 arg1Of PCR,was
R21631 T27527 T27529 arg2Of PCR,performed
R21632 T27529 T27528 arg2Of performed,was
R21633 T27529 T27530 arg1Of performed,with
R21634 T27531 T27530 arg2Of primers,with
R21635 T27531 T27532 arg1Of primers,specific
R21636 T27532 T27533 arg1Of specific,for
R21637 T27536 T27533 arg2Of promoters,for
R21638 T27536 T27534 arg1Of promoters,the
R21639 T27536 T27535 arg1Of promoters,indicated
R21640 T27537 T27538 arg1Of Values,(
R21641 T27537 T27543 arg1Of Values,are
R21642 T27537 T27544 arg2Of Values,shown
R21643 T27539 T27538 arg2Of mean ± SE,(
R21644 T27539 T27540 arg1Of mean ± SE,","
R21645 T27541 T27540 arg2Of n = 3,","
R21646 T27542 T27538 arg3Of ),(
R21647 T27544 T27543 arg2Of shown,are
R21648 T27546 T27545 arg1Of asterisks,The
R21649 T27546 T27547 arg1Of asterisks,indicate
R21650 T27547 T27559 arg1Of indicate,according
R21651 T27549 T27548 arg1Of significant,statistically
R21652 T27550 T27547 arg2Of differences,indicate
R21653 T27550 T27549 arg1Of differences,significant
R21654 T27550 T27551 arg1Of differences,compared
R21655 T27552 T27551 arg2Of to,compared
R21656 T27554 T27552 arg2Of control,to
R21657 T27554 T27553 arg1Of control,the
R21658 T27554 T27555 arg1Of control,(
R21659 T27557 T27555 arg2Of vector,(
R21660 T27557 T27556 arg1Of vector,empty
R21661 T27558 T27555 arg3Of ),(
R21662 T27560 T27559 arg2Of to,according
R21663 T27562 T27561 arg1Of Student,the
R21664 T27562 T27563 arg2Of Student,'s
R21665 T27564 T27560 arg2Of t-test,to
R21666 T27564 T27563 arg1Of t-test,'s
R21667 T27564 T27565 arg1Of t-test,(
R21668 T27566 T27565 arg2Of P ,(
R21669 T27566 T27567 arg1Of P ,<
R21670 T27567 T27568 arg1Of <, 0.05
R21671 T27569 T27565 arg3Of ),(
R22703 T29104 T29105 arg1Of Model,of
R22704 T29104 T29109 arg1Of Model,by
R22705 T29104 T29121 arg1Of Model,occupies
R22706 T29104 T29131 arg1Of Model,interacts
R22707 T29104 T29167 arg1Of Model,increasing
R22708 T29108 T29105 arg2Of activation,of
R22709 T29108 T29106 arg1Of activation,MIP-1α
R22710 T29108 T29107 arg1Of activation,transcriptional
R22711 T29111 T29109 arg2Of Tat.,by
R22712 T29111 T29110 arg1Of Tat.,HIV-1
R22713 T29111 T29112 arg1Of Tat.,(
R22714 T29111 T29115 arg1Of Tat.,In
R22715 T29113 T29112 arg2Of A,(
R22716 T29114 T29112 arg3Of ),(
R22717 T29116 T29115 arg2Of absence,In
R22718 T29116 T29117 arg1Of absence,of
R22719 T29116 T29119 arg1Of absence,","
R22720 T29118 T29117 arg2Of Tat,of
R22721 T29120 T29119 arg2Of IκB-α,","
R22722 T29121 T29129 arg1Of occupies,and
R22723 T29124 T29121 arg2Of enhancer,occupies
R22724 T29124 T29122 arg1Of enhancer,the
R22725 T29124 T29123 arg1Of enhancer,NF-κB
R22726 T29124 T29125 arg1Of enhancer,of
R22727 T29128 T29125 arg2Of promoter,of
R22728 T29128 T29126 arg1Of promoter,the
R22729 T29128 T29127 arg1Of promoter,MIP-1α
R22730 T29129 T29135 arg1Of and,","
R22731 T29129 T29137 arg1Of and,as
R22732 T29129 T29166 arg1Of and,by
R22733 T29131 T29129 arg2Of interacts,and
R22734 T29131 T29130 arg1Of interacts,likely
R22735 T29131 T29132 arg1Of interacts,with
R22736 T29134 T29132 arg2Of repressors,with
R22737 T29134 T29133 arg1Of repressors,transcriptional
R22738 T29137 T29165 arg1Of as,and
R22739 T29138 T29139 arg1Of HDACs,(
R22740 T29138 T29142 arg1Of HDACs,","
R22741 T29138 T29151 arg1Of HDACs,activates
R22742 T29138 T29156 arg1Of HDACs,removing
R22743 T29140 T29139 arg2Of 65,(
R22744 T29141 T29139 arg3Of ),(
R22745 T29144 T29142 arg2Of inhibit,","
R22746 T29144 T29143 arg1Of inhibit,to
R22747 T29148 T29147 arg2Of B,(
R22748 T29149 T29147 arg3Of ),(
R22749 T29150 T29144 arg2Of Tat,inhibit
R22750 T29150 T29145 arg1Of Tat,gene
R22751 T29150 T29146 arg1Of Tat,transcription.
R22752 T29150 T29147 arg1Of Tat,(
R22753 T29151 T29137 arg2Of activates,as
R22754 T29151 T29155 arg1Of activates,by
R22755 T29154 T29151 arg2Of expression,activates
R22756 T29154 T29152 arg1Of expression,the
R22757 T29154 T29153 arg1Of expression,MIP-1α
R22758 T29156 T29155 arg2Of removing,by
R22759 T29159 T29156 arg2Of repressor,removing
R22760 T29159 T29157 arg1Of repressor,the
R22761 T29159 T29158 arg1Of repressor,IκB-α
R22762 T29159 T29160 arg1Of repressor,from
R22763 T29163 T29160 arg2Of enhancer,from
R22764 T29163 T29161 arg1Of enhancer,the
R22765 T29163 T29162 arg1Of enhancer,NF-κB
R22766 T29165 T29136 arg1Of and,such
R22767 T29165 T29164 arg1Of and,","
R22768 T29166 T29165 arg2Of by,and
R22769 T29167 T29166 arg2Of increasing,by
R22770 T29169 T29167 arg2Of binding,increasing
R22771 T29169 T29168 arg1Of binding,the
R22772 T29169 T29170 arg1Of binding,of
R22773 T29169 T29174 arg1Of binding,to
R22774 T29173 T29170 arg2Of complex,of
R22775 T29173 T29171 arg1Of complex,p65
R22776 T29173 T29172 arg1Of complex,NF-κB
R22777 T29177 T29174 arg2Of enhancer,to
R22778 T29177 T29175 arg1Of enhancer,the
R22779 T29177 T29176 arg1Of enhancer,NF-κB
R1277 T1461 T1460 arg1Of factors,transcription
R1278 T1461 T1462 arg1Of factors,regulate
R1283 T1464 T1462 arg2Of transcription,regulate
R1284 T1464 T1463 arg1Of transcription,the
R10771 T13344 T13345 arg1Of association,with
R21358 T27266 T27267 arg1Of Tat,activates
R21359 T27266 T27275 arg1Of Tat,occupying
R21361 T27267 T27274 arg1Of activates,by
R21362 T27270 T27267 arg2Of expression,activates
R21363 T27270 T27268 arg1Of expression,the
R21364 T27270 T27269 arg1Of expression,p65-dependent
R21365 T27270 T27271 arg1Of expression,of
R21366 T27273 T27271 arg2Of genes,of
R21367 T27273 T27272 arg1Of genes,NF-κB-responsive
R21372 T27279 T27274 arg2Of and,by
R5852 T6908 T6907 arg2Of 50,(
R5853 T6909 T6907 arg3Of ),(
R5854 T6910 T6911 arg1Of Details,are
R5855 T6910 T6912 arg2Of Details,described
R5856 T6912 T6911 arg2Of described,are
R5857 T6912 T6913 arg1Of described,in
R5858 T6915 T6913 arg2Of Data,in
R5859 T6915 T6914 arg1Of Data,Supplementary

bionlp-st-ge-2016-coref

Id Subject Object Predicate Lexical cue
T13716 26840-26853 Antecedent denotes Tat R(49–57)A
T13717 27088-27099 Anaphor denotes the mutants
T13718 27100-27115 Antecedent denotes Tat T,N(23,24)A
T13719 27117-27130 Antecedent denotes Tat K(50,51)A
T13720 27135-27148 Antecedent denotes Tat R(49–57)A
T13721 27351-27367 Anaphor denotes such interaction
T13722 27236-27246 Antecedent denotes associated
T20956 40941-40958 Anaphor denotes the viral protein
T20957 40872-40875 Antecedent denotes Tat
T20958 40971-40976 Anaphor denotes which
T20959 40926-40937 Antecedent denotes association
T20960 41439-41444 Anaphor denotes which
T20961 41417-41428 Antecedent denotes association
T20962 43300-43302 Anaphor denotes it
T20963 43214-43219 Antecedent denotes IκB-α
T20964 44878-44890 Anaphor denotes the cytokine
T20965 44848-44853 Antecedent denotes TNF-α
T20966 44858-44862 Antecedent denotes IL-6
T20967 44942-44959 Anaphor denotes the 5′ transcript
T20968 44878-44890 Antecedent denotes the cytokine
T9360 15690-15692 Anaphor denotes it
T9361 15538-15548 Antecedent denotes expression
T9362 17677-17681 Anaphor denotes they
T9363 17579-17586 Antecedent denotes binding
T9364 17599-17602 Antecedent denotes p65
T9365 19438-19442 Anaphor denotes they
T9366 19366-19369 Antecedent denotes p65
T9367 19571-19574 Anaphor denotes its
T9368 19505-19508 Antecedent denotes Tat
T13713 26793-26804 Anaphor denotes the mutants
T13714 26805-26820 Antecedent denotes Tat T,N(23,24)A
T13715 26822-26835 Antecedent denotes Tat K(50,51)A
T26503 27414-27417 Anaphor denotes its
T26504 27399-27402 Antecedent denotes p65
T11963 22553-22566 Anaphor denotes the repressor
T11964 22516-22521 Antecedent denotes IκB-α
T11965 26428-26441 Anaphor denotes the repressor
T11966 26408-26413 Antecedent denotes IκB-α
T356 525-538 Anaphor denotes the repressor
T357 501-506 Antecedent denotes IκB-α
T18169 35804-35806 Anaphor denotes it
T18170 35729-35739 Antecedent denotes expression
T18171 39076-39082 Anaphor denotes effect
T18172 38993-39002 Antecedent denotes activated
T2231 4416-4449 Anaphor denotes transacting factors and cofactors
T2232 4459-4462 Antecedent denotes Sp1
T2233 4469-4474 Antecedent denotes TFIID
T2234 4481-4486 Antecedent denotes E2F-4
T2235 4493-4499 Antecedent denotes C/EBPβ
T2236 4506-4515 Antecedent denotes cyclin T1
T2237 4516-4520 Antecedent denotes CDK9
T2238 4533-4563 Anaphor denotes the histone acetyltransferases
T2239 4564-4568 Antecedent denotes p300
T2240 4569-4572 Antecedent denotes CBP
T2241 4577-4582 Antecedent denotes P/CAF
T2242 5603-5608 Anaphor denotes which
T2243 5571-5582 Antecedent denotes interaction
T15820 30671-30682 Anaphor denotes the mutants
T15821 30683-30699 Antecedent denotes Tat C(22,25,27)A
T15822 30704-30717 Antecedent denotes Tat R(49–57)A
T15823 31346-31363 Anaphor denotes the viral protein
T15824 31298-31301 Antecedent denotes Tat
T15825 32986-32991 Anaphor denotes which
T15826 32978-32984 Antecedent denotes MIP-1α
T15827 34205-34207 Anaphor denotes it
T15828 34128-34131 Antecedent denotes Tat
T15829 34553-34555 Anaphor denotes it
T15830 34456-34459 Antecedent denotes Tat
T15831 34728-34735 Anaphor denotes binding
T15832 34633-34638 Antecedent denotes bound
R16926 T20960 T20961 boundBy which,association
R16927 T20962 T20963 boundBy it,IκB-α
R16928 T20964 T20965 boundBy the cytokine,TNF-α
R16929 T20964 T20966 boundBy the cytokine,IL-6
R16930 T20967 T20964 boundBy the 5′ transcript,the cytokine
R7867 T9360 T9361 boundBy it,expression
R7868 T9362 T9363 boundBy they,binding
R7869 T9362 T9364 boundBy they,p65
R7870 T9365 T9366 boundBy they,p65
R7871 T9367 T9368 boundBy its,Tat
R11143 T13713 T13714 boundBy the mutants,"Tat T,N(23,24)A"
R11144 T13713 T13715 boundBy the mutants,"Tat K(50,51)A"
R11145 T13713 T13716 boundBy the mutants,Tat R(49–57)A
R11146 T13717 T13718 boundBy the mutants,"Tat T,N(23,24)A"
R11147 T13717 T13719 boundBy the mutants,"Tat K(50,51)A"
R11148 T13717 T13720 boundBy the mutants,Tat R(49–57)A
R11149 T13721 T13722 boundBy such interaction,associated
R16924 T20956 T20957 boundBy the viral protein,Tat
R16925 T20958 T20959 boundBy which,association
R20924 T26503 T26504 boundBy its,p65
R685 T356 T357 boundBy the repressor,IκB-α
R9815 T11963 T11964 boundBy the repressor,IκB-α
R9816 T11965 T11966 boundBy the repressor,IκB-α
R2022 T2231 T2232 boundBy transacting factors and cofactors,Sp1
R2023 T2231 T2233 boundBy transacting factors and cofactors,TFIID
R2024 T2231 T2234 boundBy transacting factors and cofactors,E2F-4
R2025 T2231 T2235 boundBy transacting factors and cofactors,C/EBPβ
R2026 T2231 T2236 boundBy transacting factors and cofactors,cyclin T1
R2027 T2231 T2237 boundBy transacting factors and cofactors,CDK9
R2030 T2238 T2239 boundBy the histone acetyltransferases,p300
R2031 T2238 T2240 boundBy the histone acetyltransferases,CBP
R2032 T2238 T2241 boundBy the histone acetyltransferases,P/CAF
R2034 T2242 T2243 boundBy which,interaction
R12781 T15820 T15821 boundBy the mutants,"Tat C(22,25,27)A"
R12782 T15820 T15822 boundBy the mutants,Tat R(49–57)A
R12783 T15823 T15824 boundBy the viral protein,Tat
R12784 T15825 T15826 boundBy which,MIP-1α
R12785 T15827 T15828 boundBy it,Tat
R12786 T15829 T15830 boundBy it,Tat
R12787 T15831 T15832 boundBy binding,bound
R14635 T18169 T18170 boundBy it,expression
R14636 T18171 T18172 boundBy effect,activated

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T402 0-5 JJ denotes Human
T403 6-22 NN denotes immunodeficiency
T404 23-30 JJ denotes virus-1
T405 31-34 NNP denotes Tat
T406 35-44 VBZ denotes activates
T407 45-50 NNP denotes NF-κB
T408 51-54 IN denotes via
T409 55-63 JJ denotes physical
T410 64-75 NN denotes interaction
T411 76-80 IN denotes with
T412 81-86 NNP denotes IκB-α
T413 87-90 CC denotes and
T414 91-94 CD denotes p65
T415 106-113 JJ denotes Nuclear
T416 114-120 NN denotes factor
T417 121-122 -LRB- denotes (
T418 122-124 NNP denotes NF
T419 124-125 -RRB- denotes )
T420 125-126 : denotes -
T421 126-128 NN denotes κB
T422 129-131 VBZ denotes is
T423 132-133 DT denotes a
T424 134-140 NN denotes master
T425 141-150 NN denotes regulator
T426 151-153 IN denotes of
T427 154-170 JJ denotes pro-inflammatory
T428 171-176 NNS denotes genes
T429 177-180 CC denotes and
T430 181-183 VBZ denotes is
T431 184-195 VBN denotes upregulated
T432 196-198 IN denotes in
T433 199-204 JJ denotes human
T434 205-221 NN denotes immunodeficiency
T435 222-227 NN denotes virus
T436 228-229 CD denotes 1
T437 230-231 -LRB- denotes (
T438 231-236 NN denotes HIV-1
T439 236-237 -RRB- denotes )
T440 238-247 NN denotes infection
T441 247-248 . denotes .
T442 249-259 NNPS denotes Mechanisms
T443 260-270 VBG denotes underlying
T444 271-274 DT denotes the
T445 275-280 JJ denotes NF-κB
T446 281-293 NN denotes deregulation
T447 294-296 IN denotes by
T448 297-302 NNP denotes HIV-1
T449 303-306 VBP denotes are
T450 307-315 JJ denotes relevant
T451 316-319 IN denotes for
T452 320-326 JJ denotes immune
T453 327-338 NN denotes dysfunction
T454 339-341 IN denotes in
T455 342-346 NNP denotes AIDS
T456 346-347 . denotes .
T457 348-350 PRP denotes We
T458 351-357 VBP denotes report
T459 358-362 IN denotes that
T460 363-365 IN denotes in
T461 366-372 JJ denotes single
T462 373-378 NN denotes round
T463 379-384 NN denotes HIV-1
T464 385-394 NN denotes infection
T465 394-395 , denotes ,
T466 396-398 CC denotes or
T467 399-411 JJ denotes single-pulse
T468 412-415 NNP denotes PMA
T469 416-427 NN denotes stimulation
T470 427-428 , denotes ,
T471 429-432 DT denotes the
T472 433-438 NNP denotes HIV-1
T473 439-442 NNP denotes Tat
T474 443-457 NN denotes transactivator
T475 458-467 VBD denotes activated
T476 468-473 JJ denotes NF-κB
T477 474-476 IN denotes by
T478 477-486 VBG denotes hijacking
T479 487-490 DT denotes the
T480 491-500 NN denotes inhibitor
T481 501-506 NN denotes IκB-α
T482 507-510 CC denotes and
T483 511-513 IN denotes by
T484 514-524 VBG denotes preventing
T485 525-528 DT denotes the
T486 529-538 NN denotes repressor
T487 539-546 JJ denotes binding
T488 547-549 TO denotes to
T489 550-553 DT denotes the
T490 554-559 JJ denotes NF-κB
T491 560-567 NN denotes complex
T492 567-568 . denotes .
T493 569-577 RB denotes Moreover
T494 577-578 , denotes ,
T495 579-582 NNP denotes Tat
T496 583-593 VBN denotes associated
T497 594-598 IN denotes with
T498 599-602 DT denotes the
T499 603-606 CD denotes p65
T500 607-614 NN denotes subunit
T501 615-617 IN denotes of
T502 618-623 NNP denotes NF-κB
T503 624-627 CC denotes and
T504 628-637 VBD denotes increased
T505 638-641 DT denotes the
T506 642-645 CD denotes p65
T507 646-657 JJ denotes DNA-binding
T508 658-666 NN denotes affinity
T509 667-670 CC denotes and
T510 671-686 JJ denotes transcriptional
T511 687-695 NN denotes activity
T512 695-696 . denotes .
T513 697-700 DT denotes The
T514 701-709 NN denotes arginine
T515 709-710 : denotes -
T516 711-714 CC denotes and
T517 715-728 JJ denotes cysteine-rich
T518 729-736 NNS denotes domains
T519 737-739 IN denotes of
T520 740-743 NNP denotes Tat
T521 744-748 VBD denotes were
T522 749-757 VBN denotes required
T523 758-761 IN denotes for
T524 762-767 NNP denotes IκB-α
T525 768-771 CC denotes and
T526 772-775 CD denotes p65
T527 776-787 NN denotes association
T528 787-788 , denotes ,
T529 789-801 RB denotes respectively
T530 801-802 , denotes ,
T531 803-806 CC denotes and
T532 807-810 IN denotes for
T533 811-821 VBG denotes sustaining
T534 822-825 DT denotes the
T535 826-831 NN denotes NF-κB
T536 832-840 NN denotes activity
T537 840-841 . denotes .
T538 842-847 IN denotes Among
T539 848-850 DT denotes an
T540 851-856 NN denotes array
T541 857-859 IN denotes of
T542 860-876 JJ denotes NF-κB-responsive
T543 877-882 NNS denotes genes
T544 882-883 , denotes ,
T545 884-887 NNP denotes Tat
T546 888-894 RB denotes mostly
T547 895-904 VBD denotes activated
T548 905-908 DT denotes the
T549 909-915 JJ denotes MIP-1α
T550 916-926 NN denotes expression
T551 927-929 IN denotes in
T552 930-931 DT denotes a
T553 932-945 JJ denotes p65-dependent
T554 946-952 NN denotes manner
T555 952-953 , denotes ,
T556 954-957 CC denotes and
T557 958-963 VBN denotes bound
T558 964-966 TO denotes to
T559 967-970 DT denotes the
T560 971-977 NNP denotes MIP-1α
T561 978-983 NNP denotes NF-κB
T562 984-992 NN denotes enhancer
T563 993-997 RB denotes thus
T564 998-1007 VBG denotes promoting
T565 1008-1011 DT denotes the
T566 1012-1023 NN denotes recruitment
T567 1024-1026 IN denotes of
T568 1027-1030 NNS denotes p65
T569 1031-1035 IN denotes with
T570 1036-1048 NN denotes displacement
T571 1049-1051 IN denotes of
T572 1052-1057 NNP denotes IκB-α
T573 1057-1058 : denotes ;
T574 1059-1066 JJ denotes similar
T575 1067-1075 NNS denotes findings
T576 1076-1080 VBD denotes were
T577 1081-1089 VBN denotes obtained
T578 1090-1093 IN denotes for
T579 1094-1097 DT denotes the
T580 1098-1114 JJ denotes NF-κB-responsive
T581 1115-1120 NNS denotes genes
T582 1121-1125 NNP denotes CSF3
T583 1125-1126 , denotes ,
T584 1127-1130 NNP denotes LTA
T585 1130-1131 , denotes ,
T586 1132-1138 NNP denotes NFKBIA
T587 1139-1142 CC denotes and
T588 1143-1147 NNP denotes TLR2
T589 1147-1148 . denotes .
T590 1149-1152 PRP$ denotes Our
T591 1153-1160 NNS denotes results
T592 1161-1168 VBP denotes support
T593 1169-1170 DT denotes a
T594 1171-1176 NN denotes novel
T595 1177-1186 NN denotes mechanism
T596 1187-1189 IN denotes of
T597 1190-1195 JJ denotes NF-κB
T598 1196-1206 NN denotes activation
T599 1207-1210 IN denotes via
T600 1211-1219 JJ denotes physical
T601 1220-1231 NN denotes interaction
T602 1232-1234 IN denotes of
T603 1235-1238 NNP denotes Tat
T604 1239-1243 IN denotes with
T605 1244-1249 NNP denotes IκB-α
T606 1250-1253 CC denotes and
T607 1254-1257 CD denotes p65
T608 1257-1258 , denotes ,
T609 1259-1262 CC denotes and
T610 1263-1266 MD denotes may
T611 1267-1277 VB denotes contribute
T612 1278-1280 TO denotes to
T613 1281-1288 JJ denotes further
T614 1289-1297 NNS denotes insights
T615 1298-1302 IN denotes into
T616 1303-1306 DT denotes the
T617 1307-1319 NN denotes deregulation
T618 1320-1322 IN denotes of
T619 1323-1326 DT denotes the
T620 1327-1339 JJ denotes inflammatory
T621 1340-1348 NN denotes response
T622 1349-1351 IN denotes by
T623 1352-1357 NNP denotes HIV-1
T624 1357-1358 . denotes .
T2329 1373-1380 NNP denotes Nuclear
T2330 1381-1387 NN denotes factor
T2331 1388-1389 -LRB- denotes (
T2332 1389-1391 NNP denotes NF
T2333 1391-1392 -RRB- denotes )
T2334 1392-1393 : denotes -
T2335 1393-1395 NN denotes κB
T2336 1396-1409 NN denotes transcription
T2337 1410-1417 NNS denotes factors
T2338 1418-1426 VB denotes regulate
T2339 1427-1430 DT denotes the
T2340 1431-1444 NN denotes transcription
T2341 1445-1447 IN denotes of
T2342 1448-1453 NNS denotes genes
T2343 1454-1458 WDT denotes that
T2344 1459-1462 VBP denotes are
T2345 1463-1471 VBN denotes involved
T2346 1472-1474 IN denotes in
T2347 1475-1478 DT denotes the
T2348 1479-1485 JJ denotes immune
T2349 1486-1489 CC denotes and
T2350 1490-1502 JJ denotes inflammatory
T2351 1503-1511 NN denotes response
T2352 1512-1513 -LRB- denotes (
T2353 1513-1514 CD denotes 1
T2354 1514-1515 -RRB- denotes )
T2355 1515-1516 . denotes .
T2356 1517-1520 DT denotes The
T2357 1521-1526 NNP denotes NF-κB
T2358 1527-1533 NN denotes family
T2359 1534-1542 VBZ denotes includes
T2360 1543-1551 NNS denotes RelA/p65
T2361 1551-1552 , denotes ,
T2362 1553-1558 NNP denotes c-Rel
T2363 1558-1559 , denotes ,
T2364 1560-1564 NNP denotes RelB
T2365 1564-1565 , denotes ,
T2366 1566-1569 CD denotes p50
T2367 1570-1573 CC denotes and
T2368 1574-1577 CD denotes p52
T2369 1578-1582 WDT denotes that
T2370 1583-1588 VBP denotes share
T2371 1589-1590 DT denotes a
T2372 1591-1597 RB denotes highly
T2373 1598-1607 VBN denotes conserved
T2374 1608-1617 JJ denotes 300-amino
T2375 1618-1622 NN denotes acid
T2376 1623-1626 NNP denotes Rel
T2377 1627-1635 NN denotes homology
T2378 1636-1642 NN denotes domain
T2379 1643-1644 -LRB- denotes (
T2380 1644-1647 NNP denotes RHD
T2381 1647-1648 -RRB- denotes )
T2382 1649-1652 IN denotes for
T2383 1653-1657 NN denotes homo
T2384 1657-1658 : denotes -
T2385 1659-1661 CC denotes or
T2386 1662-1681 NN denotes hetero-dimerization
T2387 1682-1685 CC denotes and
T2388 1686-1697 JJ denotes DNA-binding
T2389 1697-1698 . denotes .
T2390 1699-1702 DT denotes The
T2391 1703-1718 JJ denotes transcriptional
T2392 1719-1727 NN denotes activity
T2393 1728-1730 IN denotes of
T2394 1731-1734 DT denotes the
T2395 1735-1740 JJ denotes NF-κB
T2396 1741-1748 JJ denotes complex
T2397 1749-1756 VBZ denotes depends
T2398 1757-1759 IN denotes on
T2399 1760-1765 NN denotes dimer
T2400 1766-1777 NN denotes composition
T2401 1778-1783 IN denotes since
T2402 1784-1794 JJ denotes C-terminal
T2403 1795-1804 JJ denotes unrelated
T2404 1805-1820 JJ denotes transcriptional
T2405 1821-1831 NN denotes activation
T2406 1832-1839 NNS denotes domains
T2407 1840-1843 VBP denotes are
T2408 1844-1851 JJ denotes present
T2409 1852-1863 RB denotes exclusively
T2410 1864-1866 IN denotes in
T2411 1867-1870 CD denotes p65
T2412 1870-1871 , denotes ,
T2413 1872-1876 NNP denotes RelB
T2414 1877-1880 CC denotes and
T2415 1881-1886 NNP denotes c-Rel
T2416 1887-1888 -LRB- denotes (
T2417 1888-1889 LS denotes 2
T2418 1889-1890 -RRB- denotes )
T2419 1890-1891 . denotes .
T2420 1892-1902 NNS denotes Inhibitors
T2421 1903-1905 IN denotes of
T2422 1906-1911 NNP denotes NF-κB
T2423 1912-1913 -LRB- denotes (
T2424 1913-1916 NNP denotes IκB
T2425 1916-1917 -RRB- denotes )
T2426 1918-1927 NN denotes associate
T2427 1928-1932 IN denotes with
T2428 1933-1936 DT denotes the
T2429 1937-1942 NNP denotes NF-κB
T2430 1943-1950 NN denotes complex
T2431 1951-1954 CC denotes and
T2432 1955-1964 VB denotes interfere
T2433 1965-1969 IN denotes with
T2434 1970-1973 PRP$ denotes its
T2435 1974-1981 JJ denotes binding
T2436 1982-1984 TO denotes to
T2437 1985-1988 NNP denotes DNA
T2438 1989-1990 -LRB- denotes (
T2439 1990-1991 LS denotes 3
T2440 1991-1992 -RRB- denotes )
T2441 1992-1993 . denotes .
T2442 1994-1996 IN denotes In
T2443 1997-2000 DT denotes the
T2444 2001-2010 JJ denotes canonical
T2445 2011-2018 NN denotes pathway
T2446 2019-2021 IN denotes of
T2447 2022-2027 JJ denotes NF-κB
T2448 2028-2038 NN denotes activation
T2449 2038-2039 , denotes ,
T2450 2040-2043 DT denotes the
T2451 2044-2053 VBN denotes activated
T2452 2054-2057 NNP denotes IκB
T2453 2058-2064 NN denotes kinase
T2454 2065-2066 -LRB- denotes (
T2455 2066-2069 NNP denotes IKK
T2456 2069-2070 -RRB- denotes )
T2457 2071-2085 VBZ denotes phosphorylates
T2458 2086-2089 NNP denotes IκB
T2459 2090-2092 IN denotes at
T2460 2093-2101 JJ denotes specific
T2461 2102-2108 NN denotes serine
T2462 2109-2117 NNS denotes residues
T2463 2118-2122 WDT denotes that
T2464 2123-2129 VBP denotes target
T2465 2130-2133 DT denotes the
T2466 2134-2141 NN denotes protein
T2467 2142-2144 TO denotes to
T2468 2145-2159 NN denotes ubiquitination
T2469 2160-2163 CC denotes and
T2470 2164-2175 JJ denotes proteasomal
T2471 2176-2187 NN denotes degradation
T2472 2187-2188 , denotes ,
T2473 2189-2194 WDT denotes which
T2474 2195-2203 VBZ denotes releases
T2475 2204-2207 DT denotes the
T2476 2208-2218 JJ denotes functional
T2477 2219-2224 NN denotes NF-κB
T2478 2225-2232 NN denotes complex
T2479 2233-2235 IN denotes in
T2480 2236-2239 DT denotes the
T2481 2240-2247 NN denotes nucleus
T2482 2247-2248 . denotes .
T2483 2249-2254 NNP denotes IκB-α
T2484 2254-2255 , denotes ,
T2485 2256-2259 DT denotes the
T2486 2260-2264 RBS denotes most
T2487 2265-2273 JJ denotes abundant
T2488 2274-2283 NN denotes inhibitor
T2489 2284-2286 IN denotes of
T2490 2287-2292 NNP denotes NF-κB
T2491 2293-2294 -LRB- denotes (
T2492 2294-2295 LS denotes 4
T2493 2295-2296 -RRB- denotes )
T2494 2296-2297 , denotes ,
T2495 2298-2300 VBZ denotes is
T2496 2301-2315 VBN denotes phosphorylated
T2497 2316-2318 IN denotes by
T2498 2319-2322 NNP denotes IKK
T2499 2323-2325 IN denotes at
T2500 2326-2331 NNP denotes Ser32
T2501 2332-2335 CC denotes and
T2502 2336-2341 NNP denotes Ser36
T2503 2342-2343 -LRB- denotes (
T2504 2343-2344 CD denotes 5
T2505 2344-2345 -RRB- denotes )
T2506 2345-2346 , denotes ,
T2507 2347-2350 CC denotes and
T2508 2351-2363 RB denotes subsequently
T2509 2364-2377 VBD denotes ubiquitylated
T2510 2378-2380 IN denotes at
T2511 2381-2386 NNP denotes Lys21
T2512 2387-2390 CC denotes and
T2513 2391-2396 NNP denotes Lys22
T2514 2397-2399 TO denotes to
T2515 2400-2402 VB denotes be
T2516 2403-2411 JJ denotes degraded
T2517 2412-2414 IN denotes by
T2518 2415-2418 DT denotes the
T2519 2419-2422 JJ denotes 26S
T2520 2423-2433 JJ denotes proteasome
T2521 2434-2435 -LRB- denotes (
T2522 2435-2436 CD denotes 6
T2523 2436-2437 -RRB- denotes )
T2524 2437-2438 . denotes .
T2525 2439-2442 DT denotes The
T2526 2443-2448 JJ denotes NF-κB
T2527 2449-2457 NN denotes activity
T2528 2458-2460 VBZ denotes is
T2529 2461-2469 VBN denotes enhanced
T2530 2470-2472 IN denotes by
T2531 2473-2488 NN denotes phosphorylation
T2532 2489-2491 IN denotes of
T2533 2492-2495 CD denotes p65
T2534 2496-2498 IN denotes at
T2535 2499-2505 CD denotes Ser276
T2536 2506-2508 IN denotes by
T2537 2509-2512 NNP denotes PKA
T2538 2513-2516 CC denotes and
T2539 2517-2521 NNP denotes MSK1
T2540 2522-2523 -LRB- denotes (
T2541 2523-2526 CD denotes 7,8
T2542 2526-2527 -RRB- denotes )
T2543 2527-2528 , denotes ,
T2544 2529-2535 NNP denotes Ser311
T2545 2536-2538 IN denotes by
T2546 2539-2543 NNP denotes PKCζ
T2547 2544-2545 -LRB- denotes (
T2548 2545-2546 CD denotes 9
T2549 2546-2547 -RRB- denotes )
T2550 2548-2551 CC denotes and
T2551 2552-2558 NNP denotes Ser536
T2552 2559-2561 IN denotes by
T2553 2562-2566 NNP denotes IKKα
T2554 2567-2568 -LRB- denotes (
T2555 2568-2573 CD denotes 10,11
T2556 2573-2574 -RRB- denotes )
T2557 2574-2575 . denotes .
T2558 2576-2587 NNP denotes Acetylation
T2559 2588-2590 IN denotes of
T2560 2591-2594 CD denotes p65
T2561 2595-2597 IN denotes at
T2562 2598-2604 NNP denotes Lys218
T2563 2605-2608 CC denotes and
T2564 2609-2615 NNP denotes Lys221
T2565 2616-2625 VBZ denotes increases
T2566 2626-2629 DT denotes the
T2567 2630-2633 NNP denotes DNA
T2568 2634-2641 JJ denotes binding
T2569 2642-2645 CC denotes and
T2570 2646-2653 VBZ denotes impairs
T2571 2654-2657 DT denotes the
T2572 2658-2669 NN denotes association
T2573 2670-2674 IN denotes with
T2574 2675-2680 NNP denotes IκB-α
T2575 2680-2681 , denotes ,
T2576 2682-2685 CC denotes and
T2577 2686-2697 NN denotes acetylation
T2578 2698-2700 IN denotes at
T2579 2701-2707 NNP denotes Lys310
T2580 2708-2716 VBZ denotes enhances
T2581 2717-2720 DT denotes the
T2582 2721-2724 CD denotes p65
T2583 2725-2740 JJ denotes transcriptional
T2584 2741-2749 NN denotes activity
T2585 2750-2751 -LRB- denotes (
T2586 2751-2756 CD denotes 12,13
T2587 2756-2757 -RRB- denotes )
T2588 2757-2758 . denotes .
T2589 2759-2774 NN denotes Post-activation
T2590 2775-2779 VB denotes turn
T2591 2780-2783 RB denotes off
T2592 2784-2786 IN denotes of
T2593 2787-2792 NN denotes NF-κB
T2594 2793-2795 VBZ denotes is
T2595 2796-2805 VBN denotes regulated
T2596 2806-2808 IN denotes by
T2597 2809-2817 JJ denotes negative
T2598 2818-2826 NN denotes feedback
T2599 2827-2831 NN denotes loop
T2600 2832-2839 IN denotes through
T2601 2840-2850 NNS denotes inhibitors
T2602 2851-2856 IN denotes under
T2603 2857-2860 DT denotes the
T2604 2861-2876 JJ denotes transcriptional
T2605 2877-2884 NN denotes control
T2606 2885-2887 IN denotes of
T2607 2888-2893 NNP denotes NF-κB
T2608 2893-2894 , denotes ,
T2609 2895-2899 JJ denotes such
T2610 2900-2902 IN denotes as
T2611 2903-2908 JJ denotes IκB-α
T2612 2909-2912 CC denotes and
T2613 2913-2930 JJ denotes ubiquitin-editing
T2614 2931-2938 NN denotes protein
T2615 2939-2942 NNP denotes A20
T2616 2943-2944 -LRB- denotes (
T2617 2944-2946 CD denotes 14
T2618 2947-2949 CD denotes 20
T2619 2949-2950 -RRB- denotes )
T2620 2950-2951 . denotes .
T2621 2952-2965 NN denotes Deacetylation
T2622 2966-2968 IN denotes of
T2623 2969-2972 CD denotes p65
T2624 2973-2975 IN denotes by
T2625 2976-2983 NN denotes histone
T2626 2984-2997 JJ denotes deacetylase-3
T2627 2998-3000 CC denotes or
T2628 3001-3006 CD denotes SIRT1
T2629 3006-3007 , denotes ,
T2630 3008-3010 CC denotes or
T2631 3011-3022 NN denotes acetylation
T2632 3023-3025 IN denotes of
T2633 3026-3029 NNS denotes p65
T2634 3030-3032 IN denotes at
T2635 3033-3039 NNP denotes Lys122
T2636 3040-3043 CC denotes and
T2637 3044-3050 NNP denotes Lys123
T2638 3051-3064 VBP denotes down-regulate
T2639 3065-3068 DT denotes the
T2640 3069-3074 NN denotes NF-κB
T2641 3075-3083 NN denotes activity
T2642 3084-3085 -LRB- denotes (
T2643 3085-3093 CD denotes 12,21,22
T2644 3093-3094 -RRB- denotes )
T2645 3094-3095 . denotes .
T2646 3096-3106 JJ denotes Persistent
T2647 3107-3117 NN denotes activation
T2648 3118-3120 IN denotes of
T2649 3121-3126 JJ denotes NF-κB
T2650 3127-3133 VBZ denotes occurs
T2651 3134-3136 IN denotes in
T2652 3137-3142 JJ denotes human
T2653 3143-3159 NN denotes immunodeficiency
T2654 3160-3167 JJ denotes virus-1
T2655 3168-3169 -LRB- denotes (
T2656 3169-3174 NNP denotes HIV-1
T2657 3174-3175 -RRB- denotes )
T2658 3175-3176 : denotes -
T2659 3176-3184 VBN denotes infected
T2660 3185-3194 NNS denotes monocytes
T2661 3194-3195 , denotes ,
T2662 3196-3207 NNS denotes macrophages
T2663 3208-3211 CC denotes and
T2664 3212-3221 NNS denotes microglia
T2665 3221-3222 , denotes ,
T2666 3223-3226 CC denotes and
T2667 3227-3235 VBZ denotes enhances
T2668 3236-3239 DT denotes the
T2669 3240-3250 NN denotes expression
T2670 3251-3253 IN denotes of
T2671 3254-3270 JJ denotes NF-κB-responsive
T2672 3271-3276 NNS denotes genes
T2673 3276-3277 , denotes ,
T2674 3278-3287 VBG denotes including
T2675 3288-3304 JJ denotes pro-inflammatory
T2676 3305-3314 NNS denotes cytokines
T2677 3314-3315 , denotes ,
T2678 3316-3320 NN denotes cell
T2679 3321-3329 NN denotes adhesion
T2680 3330-3339 NNS denotes molecules
T2681 3340-3343 CC denotes and
T2682 3344-3354 NNS denotes chemokines
T2683 3355-3356 -LRB- denotes (
T2684 3356-3358 CD denotes 23
T2685 3359-3361 CD denotes 25
T2686 3361-3362 -RRB- denotes )
T2687 3362-3363 . denotes .
T2688 3364-3371 JJ denotes Chronic
T2689 3372-3384 NN denotes inflammation
T2690 3385-3387 VBZ denotes is
T2691 3388-3389 DT denotes a
T2692 3390-3395 JJ denotes major
T2693 3396-3401 NN denotes cause
T2694 3402-3404 IN denotes of
T2695 3405-3411 JJ denotes immune
T2696 3412-3415 CC denotes and
T2697 3416-3422 JJ denotes neuron
T2698 3423-3434 NN denotes dysfunction
T2699 3435-3437 IN denotes in
T2700 3438-3442 NNP denotes AIDS
T2701 3443-3444 -LRB- denotes (
T2702 3444-3449 CD denotes 26,27
T2703 3449-3450 -RRB- denotes )
T2704 3450-3451 . denotes .
T2705 3452-3464 RB denotes Consistently
T2706 3464-3465 , denotes ,
T2707 3466-3475 JJ denotes non-human
T2708 3476-3483 NN denotes primate
T2709 3484-3489 NNS denotes hosts
T2710 3490-3493 IN denotes for
T2711 3494-3500 JJ denotes simian
T2712 3501-3517 NN denotes immunodeficiency
T2713 3518-3523 NN denotes virus
T2714 3523-3524 , denotes ,
T2715 3525-3529 JJ denotes such
T2716 3530-3532 IN denotes as
T2717 3533-3540 JJ denotes African
T2718 3541-3546 JJ denotes green
T2719 3547-3554 NNS denotes monkeys
T2720 3555-3558 CC denotes and
T2721 3559-3564 JJ denotes sooty
T2722 3565-3573 NN denotes mangabey
T2723 3573-3574 , denotes ,
T2724 3575-3579 VBP denotes lack
T2725 3580-3588 JJ denotes aberrant
T2726 3589-3595 JJ denotes immune
T2727 3596-3606 NN denotes activation
T2728 3607-3610 CC denotes and
T2729 3611-3613 VB denotes do
T2730 3614-3617 RB denotes not
T2731 3618-3625 VB denotes develop
T2732 3626-3630 NNP denotes AIDS
T2733 3631-3638 IN denotes despite
T2734 3639-3643 JJ denotes high
T2735 3644-3649 NN denotes virus
T2736 3650-3661 NN denotes replication
T2737 3662-3663 -LRB- denotes (
T2738 3663-3668 CD denotes 28,29
T2739 3668-3669 -RRB- denotes )
T2740 3669-3670 . denotes .
T2741 3671-3675 RB denotes Thus
T2742 3675-3676 , denotes ,
T2743 3677-3690 VBG denotes understanding
T2744 3691-3694 DT denotes the
T2745 3695-3705 NNS denotes mechanisms
T2746 3706-3708 IN denotes of
T2747 3709-3714 JJ denotes NF-κB
T2748 3715-3727 NN denotes deregulation
T2749 3728-3730 IN denotes by
T2750 3731-3736 NNP denotes HIV-1
T2751 3737-3740 MD denotes may
T2752 3741-3748 VB denotes provide
T2753 3749-3756 JJ denotes further
T2754 3757-3765 NNS denotes insights
T2755 3766-3770 IN denotes into
T2756 3771-3775 NNP denotes AIDS
T2757 3776-3788 NN denotes pathogenesis
T2758 3788-3789 . denotes .
T2759 3790-3792 IN denotes In
T2760 3793-3798 JJ denotes HIV-1
T2761 3799-3804 NN denotes entry
T2762 3804-3805 , denotes ,
T2763 3806-3809 DT denotes the
T2764 3810-3817 JJ denotes binding
T2765 3818-3820 IN denotes of
T2766 3821-3824 DT denotes the
T2767 3825-3830 NNS denotes gp120
T2768 3831-3836 JJ denotes viral
T2769 3837-3845 NN denotes envelope
T2770 3846-3848 TO denotes to
T2771 3849-3852 CD denotes CD4
T2772 3853-3860 VBZ denotes induces
T2773 3861-3864 DT denotes the
T2774 3865-3870 JJ denotes NF-κB
T2775 3871-3879 NN denotes activity
T2776 3880-3882 IN denotes by
T2777 3883-3893 NN denotes activation
T2778 3894-3896 IN denotes of
T2779 3897-3900 NNP denotes IKK
T2780 3901-3902 -LRB- denotes (
T2781 3902-3904 CD denotes 30
T2782 3904-3905 -RRB- denotes )
T2783 3906-3909 CC denotes and
T2784 3910-3920 NN denotes procaspase
T2785 3921-3922 CD denotes 8
T2786 3923-3924 -LRB- denotes (
T2787 3924-3926 CD denotes 31
T2788 3926-3927 -RRB- denotes )
T2789 3927-3928 . denotes .
T2790 3929-3938 VBG denotes Following
T2791 3939-3944 JJ denotes viral
T2792 3945-3956 NN denotes integration
T2793 3956-3957 , denotes ,
T2794 3958-3961 DT denotes the
T2795 3962-3967 JJ denotes early
T2796 3968-3975 JJ denotes encoded
T2797 3976-3981 NNP denotes HIV-1
T2798 3982-3985 NNP denotes Tat
T2799 3986-3993 NN denotes protein
T2800 3994-4003 NNS denotes interacts
T2801 4004-4008 IN denotes with
T2802 4009-4012 DT denotes the
T2803 4013-4018 NNP denotes HIV-1
T2804 4019-4022 NNP denotes RNA
T2805 4023-4026 CC denotes and
T2806 4027-4031 NN denotes host
T2807 4032-4036 NN denotes cell
T2808 4037-4044 NNS denotes factors
T2809 4045-4047 TO denotes to
T2810 4048-4055 VB denotes sustain
T2811 4056-4059 DT denotes the
T2812 4060-4065 JJ denotes viral
T2813 4066-4077 NN denotes replication
T2814 4077-4078 . denotes .
T2815 4079-4082 NNP denotes Tat
T2816 4083-4088 VBZ denotes binds
T2817 4089-4091 TO denotes to
T2818 4092-4095 NNP denotes RNA
T2819 4096-4105 JJ denotes stem-loop
T2820 4106-4116 NNS denotes structures
T2821 4117-4126 VBN denotes generated
T2822 4127-4129 IN denotes by
T2823 4130-4133 DT denotes the
T2824 4134-4135 CD denotes 5
T2825 4135-4136 NN denotes ′
T2826 4137-4140 NN denotes end
T2827 4141-4143 IN denotes of
T2828 4144-4150 NN denotes target
T2829 4151-4162 NNS denotes transcripts
T2830 4162-4163 , denotes ,
T2831 4164-4173 VBG denotes including
T2832 4174-4177 DT denotes the
T2833 4178-4183 NNP denotes HIV-1
T2834 4184-4210 JJ denotes transactivation-responsive
T2835 4211-4218 NN denotes element
T2836 4219-4220 -LRB- denotes (
T2837 4220-4223 NNP denotes TAR
T2838 4223-4224 -RRB- denotes )
T2839 4225-4226 -LRB- denotes (
T2840 4226-4228 CD denotes 32
T2841 4228-4229 -RRB- denotes )
T2842 4229-4230 , denotes ,
T2843 4231-4236 NN denotes tumor
T2844 4237-4245 NN denotes necrosis
T2845 4246-4252 NN denotes factor
T2846 4253-4254 NN denotes β
T2847 4255-4256 -LRB- denotes (
T2848 4256-4260 NNP denotes TNFβ
T2849 4260-4261 -RRB- denotes )
T2850 4262-4263 -LRB- denotes (
T2851 4263-4265 CD denotes 33
T2852 4265-4266 -RRB- denotes )
T2853 4267-4270 CC denotes and
T2854 4271-4284 JJ denotes interleukin-6
T2855 4285-4286 -LRB- denotes (
T2856 4286-4290 NN denotes IL-6
T2857 4290-4291 -RRB- denotes )
T2858 4292-4293 -LRB- denotes (
T2859 4293-4295 CD denotes 34
T2860 4295-4296 -RRB- denotes )
T2861 4297-4299 TO denotes to
T2862 4300-4308 VB denotes activate
T2863 4309-4313 NN denotes gene
T2864 4314-4327 NN denotes transcription
T2865 4327-4328 . denotes .
T2866 4329-4335 RB denotes Indeed
T2867 4335-4336 , denotes ,
T2868 4337-4340 NNP denotes Tat
T2869 4341-4349 VBZ denotes promotes
T2870 4350-4353 DT denotes the
T2871 4354-4369 JJ denotes transcriptional
T2872 4370-4380 NN denotes initiation
T2873 4381-4384 CC denotes and
T2874 4385-4395 NN denotes elongation
T2875 4396-4398 IN denotes by
T2876 4399-4410 VBG denotes interacting
T2877 4411-4415 IN denotes with
T2878 4416-4427 VBG denotes transacting
T2879 4428-4435 NNS denotes factors
T2880 4436-4439 CC denotes and
T2881 4440-4449 NNS denotes cofactors
T2882 4449-4450 , denotes ,
T2883 4451-4455 JJ denotes such
T2884 4456-4458 IN denotes as
T2885 4459-4462 NNP denotes Sp1
T2886 4463-4464 -LRB- denotes (
T2887 4464-4466 CD denotes 35
T2888 4466-4467 -RRB- denotes )
T2889 4467-4468 , denotes ,
T2890 4469-4474 NNP denotes TFIID
T2891 4475-4476 -LRB- denotes (
T2892 4476-4478 CD denotes 36
T2893 4478-4479 -RRB- denotes )
T2894 4479-4480 , denotes ,
T2895 4481-4486 NNP denotes E2F-4
T2896 4487-4488 -LRB- denotes (
T2897 4488-4490 CD denotes 37
T2898 4490-4491 -RRB- denotes )
T2899 4491-4492 , denotes ,
T2900 4493-4498 NNP denotes C/EBP
T2901 4498-4499 NNP denotes β
T2902 4500-4501 -LRB- denotes (
T2903 4501-4503 CD denotes 38
T2904 4503-4504 -RRB- denotes )
T2905 4504-4505 , denotes ,
T2906 4506-4512 NN denotes cyclin
T2907 4513-4520 CD denotes T1/CDK9
T2908 4521-4522 -LRB- denotes (
T2909 4522-4527 CD denotes 39,40
T2910 4527-4528 -RRB- denotes )
T2911 4529-4532 CC denotes and
T2912 4533-4536 DT denotes the
T2913 4537-4544 NN denotes histone
T2914 4545-4563 VBZ denotes acetyltransferases
T2915 4564-4572 NNP denotes p300/CBP
T2916 4573-4576 CC denotes and
T2917 4577-4582 NNP denotes P/CAF
T2918 4583-4584 -LRB- denotes (
T2919 4584-4586 CD denotes 41
T2920 4587-4589 CD denotes 43
T2921 4589-4590 -RRB- denotes )
T2922 4590-4591 . denotes .
T2923 4592-4596 WRB denotes When
T2924 4597-4605 VBN denotes released
T2925 4606-4610 IN denotes from
T2926 4611-4625 JJ denotes HIV-1-infected
T2927 4626-4631 NNS denotes cells
T2928 4631-4632 , denotes ,
T2929 4633-4636 NNP denotes Tat
T2930 4637-4648 VBZ denotes deregulates
T2931 4649-4652 DT denotes the
T2932 4653-4657 NN denotes cell
T2933 4658-4667 VBG denotes signaling
T2934 4668-4670 IN denotes by
T2935 4671-4678 JJ denotes binding
T2936 4679-4681 TO denotes to
T2937 4682-4686 NN denotes cell
T2938 4687-4696 NNS denotes receptors
T2939 4696-4697 , denotes ,
T2940 4698-4702 JJ denotes such
T2941 4703-4705 IN denotes as
T2942 4706-4715 NNS denotes integrins
T2943 4716-4717 -LRB- denotes (
T2944 4717-4719 CD denotes 44
T2945 4719-4720 -RRB- denotes )
T2946 4720-4721 , denotes ,
T2947 4722-4730 NN denotes Flk1/KDR
T2948 4731-4739 NN denotes receptor
T2949 4740-4741 -LRB- denotes (
T2950 4741-4743 CD denotes 45
T2951 4743-4744 -RRB- denotes )
T2952 4745-4748 CC denotes and
T2953 4749-4758 JJ denotes chemokine
T2954 4759-4768 NNS denotes receptors
T2955 4769-4770 -LRB- denotes (
T2956 4770-4772 CD denotes 46
T2957 4772-4773 -RRB- denotes )
T2958 4773-4774 . denotes .
T2959 4775-4777 PRP denotes We
T2960 4778-4783 RB denotes first
T2961 4784-4792 VBD denotes reported
T2962 4793-4797 IN denotes that
T2963 4798-4803 NNP denotes NF-κB
T2964 4804-4807 VBD denotes was
T2965 4808-4822 RB denotes constitutively
T2966 4823-4829 JJ denotes active
T2967 4830-4832 IN denotes in
T2968 4833-4839 NNP denotes Jurkat
T2969 4840-4845 NNS denotes cells
T2970 4846-4850 WDT denotes that
T2971 4851-4857 RB denotes stably
T2972 4858-4867 VBD denotes expressed
T2973 4868-4871 DT denotes the
T2974 4872-4875 NNP denotes Tat
T2975 4876-4880 NN denotes gene
T2976 4881-4882 -LRB- denotes (
T2977 4882-4884 CD denotes 47
T2978 4884-4885 -RRB- denotes )
T2979 4885-4886 . denotes .
T2980 4887-4896 VBG denotes Following
T2981 4897-4901 NN denotes gene
T2982 4902-4914 NN denotes transfection
T2983 4915-4917 CC denotes or
T2984 4918-4925 NN denotes protein
T2985 4926-4938 NN denotes transduction
T2986 4938-4939 , denotes ,
T2987 4940-4943 NNP denotes Tat
T2988 4944-4951 VBD denotes induced
T2989 4952-4955 DT denotes the
T2990 4956-4959 NNP denotes IKK
T2991 4960-4968 NN denotes activity
T2992 4969-4972 CC denotes and
T2993 4973-4984 JJ denotes proteasomal
T2994 4985-4996 NN denotes degradation
T2995 4997-4999 IN denotes of
T2996 5000-5005 NNP denotes IκB-α
T2997 5006-5007 -LRB- denotes (
T2998 5007-5009 CD denotes 48
T2999 5009-5010 -RRB- denotes )
T3000 5010-5011 , denotes ,
T3001 5012-5015 CC denotes and
T3002 5016-5025 VBD denotes increased
T3003 5026-5029 DT denotes the
T3004 5030-5033 NNS denotes p65
T3005 5034-5049 JJ denotes transcriptional
T3006 5050-5058 NN denotes activity
T3007 5059-5061 IN denotes by
T3008 5062-5072 VBG denotes inhibiting
T3009 5073-5076 DT denotes the
T3010 5077-5092 JJ denotes SIRT-1-mediated
T3011 5093-5106 NN denotes deacetylation
T3012 5107-5109 IN denotes of
T3013 5110-5113 CD denotes p65
T3014 5114-5120 NNP denotes Lys310
T3015 5121-5122 -LRB- denotes (
T3016 5122-5124 CD denotes 49
T3017 5124-5125 -RRB- denotes )
T3018 5125-5126 . denotes .
T3019 5127-5132 DT denotes These
T3020 5133-5141 NNS denotes findings
T3021 5142-5151 VBD denotes suggested
T3022 5152-5156 IN denotes that
T3023 5157-5160 NNP denotes Tat
T3024 5161-5170 VBZ denotes modulates
T3025 5171-5178 JJ denotes crucial
T3026 5179-5186 NNS denotes enzymes
T3027 5187-5195 VBN denotes involved
T3028 5196-5198 IN denotes in
T3029 5199-5204 JJ denotes NF-κB
T3030 5205-5214 VBG denotes signaling
T3031 5214-5215 : denotes ;
T3032 5216-5223 RB denotes however
T3033 5223-5224 , denotes ,
T3034 5225-5227 PRP denotes it
T3035 5228-5231 VBD denotes was
T3036 5232-5239 JJ denotes unclear
T3037 5240-5243 WRB denotes how
T3038 5244-5247 NNP denotes Tat
T3039 5248-5253 MD denotes could
T3040 5254-5261 VB denotes subvert
T3041 5262-5265 DT denotes the
T3042 5266-5274 JJ denotes negative
T3043 5275-5283 NN denotes feedback
T3044 5284-5286 IN denotes of
T3045 5287-5292 NNP denotes NF-κB
T3046 5292-5293 , denotes ,
T3047 5294-5299 WDT denotes which
T3048 5300-5302 VBZ denotes is
T3049 5303-5309 RB denotes mainly
T3050 5310-5319 JJ denotes dependent
T3051 5320-5322 IN denotes on
T3052 5323-5325 FW denotes de
T3053 5326-5330 FW denotes novo
T3054 5331-5340 NN denotes synthesis
T3055 5341-5343 IN denotes of
T3056 5344-5349 NNP denotes IκB-α
T3057 5350-5351 -LRB- denotes (
T3058 5351-5356 CD denotes 15,17
T3059 5356-5357 -RRB- denotes )
T3060 5357-5358 . denotes .
T3061 5359-5361 PRP denotes We
T3062 5362-5372 RB denotes previously
T3063 5373-5378 VBD denotes found
T3064 5379-5383 IN denotes that
T3065 5384-5389 JJ denotes IκB-α
T3066 5390-5395 NNS denotes binds
T3067 5396-5398 TO denotes to
T3068 5399-5402 NNP denotes Tat
T3069 5403-5406 CC denotes and
T3070 5407-5415 VBZ denotes promotes
T3071 5416-5419 DT denotes the
T3072 5420-5427 JJ denotes nuclear
T3073 5428-5434 NN denotes export
T3074 5435-5437 IN denotes of
T3075 5438-5441 DT denotes the
T3076 5442-5447 JJ denotes viral
T3077 5448-5462 NN denotes transactivator
T3078 5463-5464 -LRB- denotes (
T3079 5464-5469 CD denotes 50,51
T3080 5469-5470 -RRB- denotes )
T3081 5470-5471 . denotes .
T3082 5472-5474 IN denotes In
T3083 5475-5479 DT denotes this
T3084 5480-5485 NN denotes study
T3085 5485-5486 , denotes ,
T3086 5487-5489 PRP denotes we
T3087 5490-5496 VBP denotes report
T3088 5497-5501 IN denotes that
T3089 5502-5505 NNP denotes Tat
T3090 5506-5517 VBZ denotes counteracts
T3091 5518-5521 DT denotes the
T3092 5522-5537 JJ denotes post-activation
T3093 5538-5542 NN denotes turn
T3094 5543-5546 IN denotes off
T3095 5547-5549 IN denotes of
T3096 5550-5555 NN denotes NF-κB
T3097 5556-5563 IN denotes through
T3098 5564-5570 JJ denotes direct
T3099 5571-5582 NN denotes interaction
T3100 5583-5587 IN denotes with
T3101 5588-5593 NNP denotes IκB-α
T3102 5594-5597 CC denotes and
T3103 5598-5601 CD denotes p65
T3104 5601-5602 , denotes ,
T3105 5603-5608 WDT denotes which
T3106 5609-5617 VBZ denotes enhances
T3107 5618-5621 DT denotes the
T3108 5622-5625 NNP denotes DNA
T3109 5626-5633 JJ denotes binding
T3110 5634-5637 CC denotes and
T3111 5638-5653 JJ denotes transcriptional
T3112 5654-5662 NN denotes activity
T3113 5663-5665 IN denotes of
T3114 5666-5669 DT denotes the
T3115 5670-5675 NNP denotes NF-κB
T3116 5676-5683 NN denotes complex
T3117 5683-5684 . denotes .
T3118 5685-5688 DT denotes The
T3119 5689-5692 JJ denotes new
T3120 5693-5702 NN denotes mechanism
T3121 5703-5705 IN denotes of
T3122 5706-5711 JJ denotes NF-κB
T3123 5712-5724 NN denotes deregulation
T3124 5725-5729 RB denotes here
T3125 5730-5739 VBD denotes described
T3126 5740-5743 MD denotes may
T3127 5744-5751 VB denotes provide
T3128 5752-5759 JJ denotes further
T3129 5760-5768 NNS denotes insights
T3130 5769-5773 IN denotes into
T3131 5774-5777 DT denotes the
T3132 5778-5785 JJ denotes chronic
T3133 5786-5792 JJ denotes immune
T3134 5793-5803 NN denotes activation
T3135 5804-5806 IN denotes of
T3136 5807-5812 JJ denotes HIV-1
T3137 5813-5822 NN denotes infection
T3138 5822-5823 . denotes .
T4596 5848-5856 NNP denotes Plasmids
T4597 5857-5860 DT denotes The
T4598 5861-5869 NNS denotes plasmids
T4599 5870-5886 NN denotes pcDNA-3xHA-IκB-α
T4600 5886-5887 , denotes ,
T4601 5888-5903 NN denotes p3xFLAG-CMV-Tat
T4602 5903-5904 , denotes ,
T4603 5905-5920 NN denotes p3xFLAG-CMV-Tat
T4604 5921-5922 NNP denotes C
T4605 5922-5923 -LRB- denotes (
T4606 5923-5931 CD denotes 22,25,27
T4607 5931-5932 -RRB- denotes )
T4608 5932-5933 DT denotes A
T4609 5933-5934 , denotes ,
T4610 5935-5950 JJ denotes p3xFLAG-CMV-Tat
T4611 5951-5952 NN denotes R
T4612 5952-5953 -LRB- denotes (
T4613 5953-5970 CD denotes 49,52,53,55,56,57
T4614 5970-5971 -RRB- denotes )
T4615 5971-5972 DT denotes A
T4616 5972-5973 , denotes ,
T4617 5974-5985 NN denotes pGEX-2T-Tat
T4618 5985-5986 , denotes ,
T4619 5987-5998 NN denotes pGEX-2T-Tat
T4620 5999-6000 NNP denotes C
T4621 6000-6001 -LRB- denotes (
T4622 6001-6009 CD denotes 22,25,27
T4623 6009-6010 -RRB- denotes )
T4624 6010-6011 DT denotes A
T4625 6012-6015 CC denotes and
T4626 6016-6027 JJ denotes pGEX-2T-Tat
T4627 6028-6029 NN denotes R
T4628 6029-6030 -LRB- denotes (
T4629 6030-6047 CD denotes 49,52,53,55,56,57
T4630 6047-6048 -RRB- denotes )
T4631 6048-6049 DT denotes A
T4632 6050-6054 VBD denotes were
T4633 6055-6065 RB denotes previously
T4634 6066-6075 VBN denotes described
T4635 6076-6077 -LRB- denotes (
T4636 6077-6079 CD denotes 50
T4637 6079-6080 -RRB- denotes )
T4638 6080-6081 . denotes .
T4639 6082-6085 DT denotes The
T4640 6086-6094 NNS denotes plasmids
T4641 6095-6101 JJ denotes pNL4-3
T4642 6101-6102 . denotes .
T4643 6102-6109 SYM denotes Luc.R-E
T4644 6109-6110 : denotes -
T4645 6111-6114 CC denotes and
T4646 6115-6124 JJ denotes pHXB2-env
T4647 6125-6129 VBD denotes were
T4648 6130-6138 VBN denotes obtained
T4649 6139-6143 IN denotes from
T4650 6144-6147 DT denotes the
T4651 6148-6152 NNP denotes AIDS
T4652 6153-6161 NNP denotes Research
T4653 6162-6163 CC denotes &
T4654 6164-6173 NNP denotes Reference
T4655 6174-6181 NNP denotes Reagent
T4656 6182-6189 NNP denotes Program
T4657 6189-6190 , denotes ,
T4658 6191-6199 NNP denotes Division
T4659 6200-6202 IN denotes of
T4660 6203-6207 NNP denotes AIDS
T4661 6207-6208 , denotes ,
T4662 6209-6214 NNP denotes NIAID
T4663 6214-6215 , denotes ,
T4664 6216-6219 NNP denotes NIH
T4665 6219-6220 , denotes ,
T4666 6221-6224 NNP denotes USA
T4667 6224-6225 : denotes ;
T4668 6226-6232 NNP denotes pκBluc
T4669 6233-6236 CC denotes and
T4670 6237-6246 JJ denotes pSV-β-Gal
T4671 6247-6251 VBD denotes were
T4672 6252-6261 VBN denotes purchased
T4673 6262-6266 IN denotes from
T4674 6267-6274 NNP denotes Promega
T4675 6275-6276 -LRB- denotes (
T4676 6276-6283 NNP denotes Madison
T4677 6283-6284 , denotes ,
T4678 6285-6287 NNP denotes WI
T4679 6287-6288 , denotes ,
T4680 6289-6292 NNP denotes USA
T4681 6292-6293 -RRB- denotes )
T4682 6293-6294 . denotes .
T4683 6295-6298 DT denotes The
T4684 6299-6307 NNS denotes plasmids
T4685 6308-6315 NNP denotes pRc/CMV
T4686 6315-6317 CD denotes -3
T4687 6317-6324 NNP denotes xHA-p65
T4688 6324-6325 , denotes ,
T4689 6326-6333 NNP denotes pRc/CMV
T4690 6333-6335 CD denotes -3
T4691 6335-6344 NN denotes xHA-p65ΔC
T4692 6344-6345 -LRB- denotes (
T4693 6345-6346 CD denotes 1
T4694 6347-6350 CD denotes 318
T4695 6350-6351 -RRB- denotes )
T4696 6351-6352 , denotes ,
T4697 6353-6360 NNP denotes pRc/CMV
T4698 6360-6362 CD denotes -3
T4699 6362-6371 NNP denotes xHA-p65ΔN
T4700 6371-6372 -LRB- denotes (
T4701 6372-6375 CD denotes 122
T4702 6376-6379 CD denotes 551
T4703 6379-6380 -RRB- denotes )
T4704 6380-6381 , denotes ,
T4705 6382-6397 JJ denotes p3xFLAG-CMV-Tat
T4706 6398-6399 NNP denotes T
T4707 6399-6400 , denotes ,
T4708 6400-6401 NNP denotes N
T4709 6401-6402 -LRB- denotes (
T4710 6402-6407 CD denotes 23,24
T4711 6407-6408 -RRB- denotes )
T4712 6408-6409 DT denotes A
T4713 6409-6410 , denotes ,
T4714 6411-6426 JJ denotes p3xFLAG-CMV-Tat
T4715 6427-6428 NNP denotes K
T4716 6428-6429 -LRB- denotes (
T4717 6429-6434 CD denotes 50,51
T4718 6434-6435 -RRB- denotes )
T4719 6435-6436 DT denotes A
T4720 6436-6437 , denotes ,
T4721 6438-6449 JJ denotes pGEX-2T-Tat
T4722 6450-6451 NNP denotes T
T4723 6451-6452 , denotes ,
T4724 6452-6453 NNP denotes N
T4725 6453-6454 -LRB- denotes (
T4726 6454-6459 CD denotes 23,24
T4727 6459-6460 -RRB- denotes )
T4728 6460-6461 DT denotes A
T4729 6461-6462 , denotes ,
T4730 6463-6474 JJ denotes pGEX-2T-Tat
T4731 6475-6476 NNP denotes K
T4732 6476-6477 -LRB- denotes (
T4733 6477-6482 CD denotes 50,51
T4734 6482-6483 -RRB- denotes )
T4735 6483-6484 DT denotes A
T4736 6485-6488 CC denotes and
T4737 6489-6495 JJ denotes pNL4-3
T4738 6495-6496 . denotes .
T4739 6496-6504 NN denotes FLAG-Tat
T4740 6504-6505 . denotes .
T4741 6505-6508 SYM denotes R-E
T4742 6508-6509 : denotes -
T4743 6510-6514 VBD denotes were
T4744 6515-6524 VBN denotes generated
T4745 6525-6527 IN denotes as
T4746 6528-6537 VBN denotes described
T4747 6538-6540 IN denotes in
T4748 6541-6554 NNP denotes Supplementary
T4749 6555-6559 NNP denotes Data
T4750 6559-6560 . denotes .
T5199 6562-6567 NNS denotes Cells
T5200 6567-6568 , denotes ,
T5201 6569-6581 NN denotes transfection
T5202 6581-6582 , denotes ,
T5203 6583-6593 NNS denotes treatments
T5204 6594-6597 CC denotes and
T5205 6598-6608 NN denotes luciferase
T5206 6609-6614 NN denotes assay
T5207 6615-6619 NNP denotes HeLa
T5208 6619-6620 , denotes ,
T5209 6621-6624 CD denotes p50
T5210 6624-6625 FW denotes −
T5211 6625-6626 FW denotes /
T5212 6626-6627 FW denotes −
T5213 6627-6630 FW denotes p65
T5214 6630-6631 FW denotes −
T5215 6631-6632 FW denotes /
T5216 6632-6633 FW denotes −
T5217 6634-6639 NN denotes mouse
T5218 6640-6649 JJ denotes embryonic
T5219 6650-6661 NNS denotes fibroblasts
T5220 6662-6663 -LRB- denotes (
T5221 6663-6667 NNS denotes MEFs
T5222 6667-6668 -RRB- denotes )
T5223 6669-6670 -LRB- denotes (
T5224 6670-6672 CD denotes 52
T5225 6672-6673 -RRB- denotes )
T5226 6674-6677 CC denotes and
T5227 6678-6682 JJ denotes 293T
T5228 6683-6688 NNS denotes cells
T5229 6689-6693 VBD denotes were
T5230 6694-6702 VBN denotes cultured
T5231 6703-6705 IN denotes in
T5232 6706-6714 NNP denotes Dulbecco
T5233 6714-6716 POS denotes 's
T5234 6717-6725 VBN denotes modified
T5235 6726-6731 NNP denotes Eagle
T5236 6731-6733 POS denotes 's
T5237 6734-6740 NN denotes medium
T5238 6740-6741 : denotes ;
T5239 6742-6748 NNP denotes Jurkat
T5240 6748-6749 , denotes ,
T5241 6750-6754 NNP denotes U937
T5242 6755-6760 NNS denotes cells
T5243 6761-6764 CC denotes and
T5244 6765-6770 JJ denotes human
T5245 6771-6781 JJ denotes peripheral
T5246 6782-6787 NN denotes blood
T5247 6788-6799 NN denotes mononuclear
T5248 6800-6805 NNS denotes cells
T5249 6806-6807 -LRB- denotes (
T5250 6807-6812 NNS denotes PBMCs
T5251 6812-6813 -RRB- denotes )
T5252 6814-6818 VBD denotes were
T5253 6819-6827 VBN denotes cultured
T5254 6828-6830 IN denotes in
T5255 6831-6835 NNP denotes RPMI
T5256 6836-6840 CD denotes 1640
T5257 6840-6841 . denotes .
T5258 6842-6847 NNS denotes PBMCs
T5259 6848-6852 VBD denotes were
T5260 6853-6861 VBN denotes isolated
T5261 6862-6864 IN denotes as
T5262 6865-6875 RB denotes previously
T5263 6876-6885 VBN denotes described
T5264 6886-6887 -LRB- denotes (
T5265 6887-6889 CD denotes 53
T5266 6889-6890 -RRB- denotes )
T5267 6890-6891 . denotes .
T5268 6892-6897 NNP denotes Media
T5269 6898-6902 VBD denotes were
T5270 6903-6915 VBN denotes supplemented
T5271 6916-6920 IN denotes with
T5272 6921-6923 CD denotes 10
T5273 6923-6924 NN denotes %
T5274 6925-6941 JJ denotes heat-inactivated
T5275 6942-6947 JJ denotes fetal
T5276 6948-6952 NN denotes calf
T5277 6953-6958 NN denotes serum
T5278 6959-6962 CC denotes and
T5279 6963-6964 CD denotes 2
T5280 6965-6967 NNP denotes mM
T5281 6968-6979 NN denotes l-glutamine
T5282 6980-6981 -LRB- denotes (
T5283 6981-6986 NNP denotes Lonza
T5284 6987-6994 NNP denotes Cologne
T5285 6995-6997 NNP denotes AG
T5286 6997-6998 , denotes ,
T5287 6999-7006 NNP denotes Germany
T5288 7006-7007 -RRB- denotes )
T5289 7007-7008 . denotes .
T5290 7009-7013 NNP denotes HeLa
T5291 7013-7014 , denotes ,
T5292 7015-7018 CD denotes p50
T5293 7018-7019 FW denotes −
T5294 7019-7020 FW denotes /
T5295 7020-7021 FW denotes −
T5296 7021-7024 FW denotes p65
T5297 7024-7025 FW denotes −
T5298 7025-7026 FW denotes /
T5299 7026-7027 FW denotes −
T5300 7028-7032 NNPS denotes MEFs
T5301 7033-7036 CC denotes and
T5302 7037-7041 NNP denotes 293T
T5303 7042-7046 VBD denotes were
T5304 7047-7058 VBN denotes transfected
T5305 7059-7063 IN denotes with
T5306 7064-7067 NN denotes DNA
T5307 7068-7070 IN denotes by
T5308 7071-7076 VBG denotes using
T5309 7077-7083 NNP denotes FuGENE
T5310 7084-7086 NNP denotes HD
T5311 7087-7088 -LRB- denotes (
T5312 7088-7093 NNP denotes Roche
T5313 7094-7104 NNP denotes Diagnostic
T5314 7105-7109 NNP denotes GmbH
T5315 7109-7110 , denotes ,
T5316 7111-7119 NNP denotes Mannheim
T5317 7119-7120 , denotes ,
T5318 7121-7128 NNP denotes Germany
T5319 7128-7129 -RRB- denotes )
T5320 7129-7130 , denotes ,
T5321 7131-7140 VBG denotes according
T5322 7141-7143 TO denotes to
T5323 7144-7147 DT denotes the
T5324 7148-7160 NN denotes manufacturer
T5325 7160-7162 POS denotes 's
T5326 7163-7171 NN denotes protocol
T5327 7171-7172 : denotes ;
T5328 7173-7178 JJ denotes total
T5329 7179-7182 NNP denotes DNA
T5330 7183-7190 NNS denotes amounts
T5331 7191-7195 VBD denotes were
T5332 7196-7205 VBN denotes equalized
T5333 7206-7208 IN denotes by
T5334 7209-7221 NN denotes transfection
T5335 7222-7224 IN denotes of
T5336 7225-7232 NNP denotes pRc/CMV
T5337 7233-7238 JJ denotes empty
T5338 7239-7245 NN denotes vector
T5339 7246-7247 -LRB- denotes (
T5340 7247-7257 NNP denotes Invitrogen
T5341 7257-7258 , denotes ,
T5342 7259-7267 NNP denotes Carlsbad
T5343 7267-7268 , denotes ,
T5344 7269-7271 NNP denotes CA
T5345 7271-7272 , denotes ,
T5346 7273-7276 NNP denotes USA
T5347 7276-7277 -RRB- denotes )
T5348 7277-7278 . denotes .
T5349 7279-7282 IN denotes For
T5350 7283-7300 NN denotes pulse-stimulation
T5351 7300-7301 , denotes ,
T5352 7302-7306 NNP denotes HeLa
T5353 7307-7312 NNS denotes cells
T5354 7313-7317 VBD denotes were
T5355 7318-7325 VBN denotes treated
T5356 7326-7330 IN denotes with
T5357 7331-7338 NN denotes phorbol
T5358 7339-7351 JJ denotes 12-myristate
T5359 7352-7362 JJ denotes 13-acetate
T5360 7363-7364 -LRB- denotes (
T5361 7364-7367 NNP denotes PMA
T5362 7367-7368 : denotes ;
T5363 7369-7382 NNP denotes Sigma-Aldrich
T5364 7382-7383 , denotes ,
T5365 7384-7386 NNP denotes St
T5366 7387-7392 NNP denotes Louis
T5367 7392-7393 , denotes ,
T5368 7394-7396 NNP denotes MO
T5369 7396-7397 , denotes ,
T5370 7398-7401 NNP denotes USA
T5371 7401-7402 -RRB- denotes )
T5372 7403-7404 -LRB- denotes (
T5373 7404-7406 CD denotes 20
T5374 7407-7412 NN denotes ng/ml
T5375 7412-7413 -RRB- denotes )
T5376 7414-7417 IN denotes for
T5377 7418-7419 CD denotes 5
T5378 7420-7423 NN denotes min
T5379 7423-7424 , denotes ,
T5380 7425-7427 CC denotes or
T5381 7428-7433 NN denotes tumor
T5382 7434-7442 NN denotes necrosis
T5383 7443-7451 NN denotes factor-α
T5384 7452-7453 -LRB- denotes (
T5385 7453-7458 JJ denotes TNF-α
T5386 7458-7459 : denotes ;
T5387 7460-7473 NNP denotes Sigma-Aldrich
T5388 7473-7474 -RRB- denotes )
T5389 7475-7476 -LRB- denotes (
T5390 7476-7478 CD denotes 20
T5391 7479-7484 NN denotes ng/ml
T5392 7484-7485 -RRB- denotes )
T5393 7486-7489 IN denotes for
T5394 7490-7492 CD denotes 30
T5395 7493-7496 NN denotes min
T5396 7496-7497 , denotes ,
T5397 7498-7504 VBD denotes washed
T5398 7505-7510 RB denotes twice
T5399 7511-7513 IN denotes in
T5400 7514-7522 JJ denotes complete
T5401 7523-7530 NN denotes culture
T5402 7531-7537 NN denotes medium
T5403 7538-7541 CC denotes and
T5404 7542-7546 RB denotes then
T5405 7547-7555 VBD denotes returned
T5406 7556-7558 TO denotes to
T5407 7559-7566 NN denotes culture
T5408 7566-7567 . denotes .
T5409 7568-7571 IN denotes For
T5410 7572-7582 NN denotes luciferase
T5411 7583-7589 NNS denotes assays
T5412 7589-7590 , denotes ,
T5413 7591-7600 JJ denotes pSV-β-Gal
T5414 7601-7604 VBD denotes was
T5415 7605-7619 VBN denotes co-transfected
T5416 7620-7624 IN denotes with
T5417 7625-7631 NNP denotes pκBluc
T5418 7632-7634 TO denotes to
T5419 7635-7642 VB denotes monitor
T5420 7643-7646 DT denotes the
T5421 7647-7659 NN denotes transfection
T5422 7660-7670 NN denotes efficiency
T5423 7670-7671 . denotes .
T5424 7672-7688 JJ denotes Forty-eight-hour
T5425 7689-7706 NN denotes post-transfection
T5426 7706-7707 , denotes ,
T5427 7708-7713 NNS denotes cells
T5428 7714-7718 VBD denotes were
T5429 7719-7724 VBN denotes lysed
T5430 7725-7727 IN denotes in
T5431 7728-7733 NN denotes lysis
T5432 7734-7740 NN denotes buffer
T5433 7741-7743 IN denotes of
T5434 7744-7748 NNP denotes Dual
T5435 7749-7754 NNP denotes Light
T5436 7755-7765 NNP denotes Luciferase
T5437 7766-7772 NNP denotes System
T5438 7773-7774 -LRB- denotes (
T5439 7774-7780 NNP denotes Tropix
T5440 7780-7781 , denotes ,
T5441 7782-7789 NNP denotes Bedford
T5442 7789-7790 , denotes ,
T5443 7791-7793 NNP denotes MA
T5444 7793-7794 , denotes ,
T5445 7795-7798 NNP denotes USA
T5446 7798-7799 -RRB- denotes )
T5447 7800-7803 CC denotes and
T5448 7804-7807 DT denotes the
T5449 7808-7818 NN denotes luciferase
T5450 7819-7822 CC denotes and
T5451 7823-7838 JJ denotes β-galactosidase
T5452 7839-7849 NNS denotes activities
T5453 7850-7854 VBD denotes were
T5454 7855-7864 VBN denotes evaluated
T5455 7865-7867 IN denotes by
T5456 7868-7873 VBG denotes using
T5457 7874-7878 NNP denotes Dual
T5458 7879-7884 NNP denotes Light
T5459 7885-7895 NNP denotes Luciferase
T5460 7896-7902 NNP denotes System
T5461 7903-7904 -LRB- denotes (
T5462 7904-7910 NNP denotes Tropix
T5463 7910-7911 -RRB- denotes )
T5464 7912-7914 IN denotes in
T5465 7915-7916 DT denotes a
T5466 7917-7931 NN denotes bioluminometer
T5467 7932-7933 -LRB- denotes (
T5468 7933-7939 NNP denotes Turner
T5469 7940-7949 NNP denotes Biosystem
T5470 7949-7950 , denotes ,
T5471 7951-7960 NNP denotes Sunnyvale
T5472 7960-7961 , denotes ,
T5473 7962-7964 NNP denotes CA
T5474 7964-7965 , denotes ,
T5475 7966-7969 NNP denotes USA
T5476 7969-7970 -RRB- denotes )
T5477 7970-7971 . denotes .
T5478 7972-7975 DT denotes The
T5479 7976-7981 NN denotes ratio
T5480 7982-7984 IN denotes of
T5481 7985-7992 RB denotes firefly
T5482 7993-8003 JJ denotes luciferase
T5483 8004-8012 NN denotes activity
T5484 8013-8015 TO denotes to
T5485 8016-8031 JJ denotes β-galactosidase
T5486 8032-8040 NN denotes activity
T5487 8041-8044 VBD denotes was
T5488 8045-8054 VBN denotes expressed
T5489 8055-8057 IN denotes as
T5490 8058-8066 JJ denotes relative
T5491 8067-8072 JJ denotes light
T5492 8073-8078 NNS denotes units
T5493 8078-8079 . denotes .
T5824 8081-8084 NNP denotes RNA
T5825 8085-8097 NN denotes interference
T5826 8098-8104 NNP denotes Jurkat
T5827 8105-8107 CC denotes or
T5828 8108-8112 NNP denotes U937
T5829 8113-8118 NNS denotes cells
T5830 8119-8123 VBD denotes were
T5831 8124-8135 VBN denotes transfected
T5832 8136-8138 IN denotes by
T5833 8139-8154 NN denotes electroporation
T5834 8155-8160 VBG denotes using
T5835 8161-8162 DT denotes a
T5836 8163-8170 NNP denotes Bio-Rad
T5837 8171-8180 NN denotes apparatus
T5838 8181-8182 -LRB- denotes (
T5839 8182-8189 NNP denotes Bio-Rad
T5840 8190-8202 NNPS denotes Laboratories
T5841 8202-8203 , denotes ,
T5842 8204-8212 NNP denotes Hercules
T5843 8212-8213 , denotes ,
T5844 8214-8216 NNP denotes CA
T5845 8216-8217 , denotes ,
T5846 8218-8221 NNP denotes USA
T5847 8221-8222 -RRB- denotes )
T5848 8222-8223 . denotes .
T5849 8224-8231 RB denotes Briefly
T5850 8231-8232 , denotes ,
T5851 8233-8241 NNS denotes aliquots
T5852 8242-8243 -LRB- denotes (
T5853 8243-8244 CD denotes 5
T5854 8245-8246 CD denotes ×
T5855 8247-8250 CD denotes 106
T5856 8251-8256 NNS denotes cells
T5857 8256-8257 -RRB- denotes )
T5858 8258-8262 VBD denotes were
T5859 8263-8272 VBN denotes suspended
T5860 8273-8275 IN denotes in
T5861 8276-8279 CD denotes 0.3
T5862 8280-8282 NN denotes ml
T5863 8283-8285 IN denotes of
T5864 8286-8290 NNP denotes RPMI
T5865 8291-8295 CD denotes 1640
T5866 8296-8308 VBN denotes supplemented
T5867 8309-8313 IN denotes with
T5868 8314-8316 CD denotes 20
T5869 8316-8317 NN denotes %
T5870 8318-8323 JJ denotes fetal
T5871 8324-8328 NN denotes calf
T5872 8329-8334 NN denotes serum
T5873 8335-8338 CC denotes and
T5874 8339-8348 VBN denotes subjected
T5875 8349-8351 TO denotes to
T5876 8352-8353 DT denotes a
T5877 8354-8360 JJ denotes double
T5878 8361-8371 JJ denotes electrical
T5879 8372-8377 NN denotes pulse
T5880 8378-8379 -LRB- denotes (
T5881 8379-8383 CD denotes 0.22
T5882 8384-8385 NNP denotes V
T5883 8385-8386 , denotes ,
T5884 8387-8390 CD denotes 960
T5885 8391-8393 NN denotes µF
T5886 8393-8394 -RRB- denotes )
T5887 8395-8397 IN denotes in
T5888 8398-8401 DT denotes the
T5889 8402-8410 NN denotes presence
T5890 8411-8413 IN denotes of
T5891 8414-8422 JJ denotes annealed
T5892 8423-8428 NNP denotes siRNA
T5893 8429-8430 -LRB- denotes (
T5894 8430-8433 CD denotes 200
T5895 8434-8438 NN denotes pmol
T5896 8438-8439 -RRB- denotes )
T5897 8439-8440 : denotes ;
T5898 8441-8455 VBD denotes electroporated
T5899 8456-8461 NNS denotes cells
T5900 8462-8466 VBD denotes were
T5901 8467-8473 VBN denotes washed
T5902 8474-8477 CC denotes and
T5903 8478-8486 VBN denotes cultured
T5904 8487-8489 IN denotes in
T5905 8490-8498 JJ denotes complete
T5906 8499-8505 NN denotes medium
T5907 8505-8506 . denotes .
T5908 8507-8510 NNP denotes RNA
T5909 8511-8523 NN denotes interference
T5910 8524-8527 VBD denotes was
T5911 8528-8537 VBN denotes performed
T5912 8538-8542 IN denotes with
T5913 8542-8543 : denotes :
T5914 8544-8549 NNP denotes siRNA
T5915 8550-8553 NNP denotes Tat
T5916 8554-8559 NN denotes sense
T5917 8559-8560 , denotes ,
T5918 8561-8582 NNP denotes CUGCUUGUACCAAUUGCUAUU
T5919 8583-8586 CC denotes and
T5920 8587-8592 NNP denotes siRNA
T5921 8593-8596 NNP denotes Tat
T5922 8597-8606 NN denotes antisense
T5923 8606-8607 , denotes ,
T5924 8608-8629 NNP denotes UAGCAAUUGGUACAAGCAGUU
T5925 8629-8630 : denotes ;
T5926 8631-8636 NNP denotes siRNA
T5927 8637-8644 NN denotes control
T5928 8645-8650 NN denotes sense
T5929 8650-8651 , denotes ,
T5930 8652-8664 NNP denotes CUGCUUGUCACA
T5931 8665-8674 NNP denotes AUUGCUAUU
T5932 8675-8678 CC denotes and
T5933 8679-8684 NNP denotes siRNA
T5934 8685-8692 NN denotes control
T5935 8693-8702 NN denotes antisense
T5936 8702-8703 , denotes ,
T5937 8704-8725 NNP denotes UAGCAAUUGUGACAAGCAGUU
T5938 8725-8726 . denotes .
T5939 8727-8730 NNP denotes RNA
T5940 8731-8743 NN denotes interference
T5941 8744-8746 IN denotes of
T5942 8747-8750 CD denotes p65
T5943 8751-8754 CC denotes and
T5944 8755-8760 NNP denotes IκB-α
T5945 8761-8764 VBD denotes was
T5946 8765-8774 VBN denotes performed
T5947 8775-8779 IN denotes with
T5948 8780-8785 NNP denotes SMART
T5949 8786-8790 NN denotes pool
T5950 8791-8796 NNP denotes siRNA
T5951 8797-8800 CD denotes p65
T5952 8801-8804 CC denotes and
T5953 8805-8810 NNP denotes IκB-α
T5954 8811-8812 -LRB- denotes (
T5955 8812-8821 NNP denotes Dharmacon
T5956 8821-8822 , denotes ,
T5957 8823-8830 NNP denotes Chicago
T5958 8830-8831 , denotes ,
T5959 8832-8834 NNP denotes IL
T5960 8834-8835 , denotes ,
T5961 8836-8839 NNP denotes USA
T5962 8839-8840 -RRB- denotes )
T5963 8840-8841 . denotes .
T6139 8843-8854 NNP denotes Pseudotyped
T6140 8855-8862 NNS denotes virions
T6141 8863-8866 CC denotes and
T6142 8867-8873 JJ denotes single
T6143 8874-8879 NN denotes round
T6144 8880-8889 NN denotes infection
T6145 8890-8894 JJ denotes 293T
T6146 8895-8900 NNS denotes cells
T6147 8901-8902 -LRB- denotes (
T6148 8902-8903 CD denotes 1
T6149 8904-8905 CD denotes ×
T6150 8906-8909 CD denotes 107
T6151 8909-8910 -RRB- denotes )
T6152 8911-8915 VBD denotes were
T6153 8916-8927 VBN denotes transfected
T6154 8928-8932 IN denotes with
T6155 8933-8939 JJ denotes pNL4-3
T6156 8939-8940 . denotes .
T6157 8940-8947 SYM denotes Luc.R-E
T6158 8947-8948 : denotes -
T6159 8949-8951 CC denotes or
T6160 8952-8958 JJ denotes pNL4-3
T6161 8958-8959 . denotes .
T6162 8959-8967 NN denotes FLAG-Tat
T6163 8967-8968 . denotes .
T6164 8968-8971 SYM denotes R-E
T6165 8971-8972 : denotes -
T6166 8973-8974 -LRB- denotes (
T6167 8974-8976 CD denotes 10
T6168 8977-8979 NN denotes µg
T6169 8979-8980 -RRB- denotes )
T6170 8981-8989 RB denotes together
T6171 8990-8994 IN denotes with
T6172 8995-9000 NNP denotes pHXB2
T6173 9001-9004 NNP denotes Env
T6174 9005-9006 -LRB- denotes (
T6175 9006-9008 CD denotes 10
T6176 9009-9011 NN denotes µg
T6177 9011-9012 -RRB- denotes )
T6178 9012-9013 , denotes ,
T6179 9014-9017 CC denotes and
T6180 9018-9022 JJ denotes 48-h
T6181 9023-9040 JJ denotes post-transfection
T6182 9041-9045 NN denotes cell
T6183 9046-9057 NN denotes supernatant
T6184 9058-9061 VBD denotes was
T6185 9062-9071 VBN denotes collected
T6186 9071-9072 . denotes .
T6187 9073-9086 JJ denotes Enzyme-linked
T6188 9087-9100 JJ denotes immunosorbent
T6189 9101-9106 NN denotes assay
T6190 9107-9108 -LRB- denotes (
T6191 9108-9113 NNP denotes ELISA
T6192 9113-9114 -RRB- denotes )
T6193 9115-9120 VBG denotes using
T6194 9121-9129 JJ denotes anti-p24
T6195 9130-9138 NN denotes antibody
T6196 9139-9147 VBN denotes measured
T6197 9148-9154 NN denotes virion
T6198 9155-9168 NN denotes concentration
T6199 9168-9169 . denotes .
T6200 9170-9175 NNS denotes PBMCs
T6201 9175-9176 , denotes ,
T6202 9177-9183 NNP denotes Jurkat
T6203 9184-9186 CC denotes or
T6204 9187-9191 NNP denotes U937
T6205 9192-9197 NNS denotes cells
T6206 9198-9199 -LRB- denotes (
T6207 9199-9200 CD denotes 5
T6208 9201-9202 RB denotes ×
T6209 9203-9206 CD denotes 107
T6210 9206-9207 -RRB- denotes )
T6211 9208-9212 VBD denotes were
T6212 9213-9221 VBN denotes infected
T6213 9222-9226 IN denotes with
T6214 9227-9231 NNP denotes HXB2
T6215 9232-9247 JJ denotes Env-pseudotyped
T6216 9248-9255 NNS denotes virions
T6217 9256-9257 -LRB- denotes (
T6218 9257-9260 CD denotes 500
T6219 9261-9263 NN denotes ng
T6220 9264-9266 IN denotes of
T6221 9267-9270 CD denotes p24
T6222 9270-9271 -RRB- denotes )
T6223 9272-9274 IN denotes by
T6224 9275-9288 NN denotes spinoculation
T6225 9288-9289 , denotes ,
T6226 9290-9292 IN denotes as
T6227 9293-9303 RB denotes previously
T6228 9304-9313 VBN denotes described
T6229 9314-9315 -LRB- denotes (
T6230 9315-9317 CD denotes 50
T6231 9317-9318 -RRB- denotes )
T6232 9318-9319 . denotes .
T6307 9321-9325 NN denotes Cell
T6308 9326-9334 NNS denotes extracts
T6309 9334-9335 , denotes ,
T6310 9336-9343 JJ denotes western
T6311 9344-9352 VBG denotes blotting
T6312 9352-9353 , denotes ,
T6313 9354-9357 NNP denotes IKK
T6314 9358-9366 NN denotes activity
T6315 9367-9370 CC denotes and
T6316 9371-9376 NNP denotes NF-κB
T6317 9377-9380 NNP denotes DNA
T6318 9381-9388 JJ denotes binding
T6319 9389-9394 NNP denotes Total
T6320 9394-9395 , denotes ,
T6321 9396-9403 JJ denotes nuclear
T6322 9404-9407 CC denotes and
T6323 9408-9417 JJ denotes cytosolic
T6324 9418-9426 NNS denotes extracts
T6325 9427-9431 VBD denotes were
T6326 9432-9441 VBN denotes performed
T6327 9442-9444 IN denotes as
T6328 9445-9455 RB denotes previously
T6329 9456-9465 VBN denotes described
T6330 9466-9467 -LRB- denotes (
T6331 9467-9469 CD denotes 54
T6332 9469-9470 -RRB- denotes )
T6333 9470-9471 : denotes ;
T6334 9472-9479 NNS denotes details
T6335 9480-9483 VBP denotes are
T6336 9484-9492 VBN denotes reported
T6337 9493-9495 IN denotes in
T6338 9496-9509 NNP denotes Supplementary
T6339 9510-9514 NNP denotes Data
T6340 9514-9515 . denotes .
T6341 9516-9523 JJ denotes Western
T6342 9524-9532 VBG denotes blotting
T6343 9533-9541 NN denotes analysis
T6344 9542-9545 VBD denotes was
T6345 9546-9555 VBN denotes performed
T6346 9556-9558 IN denotes by
T6347 9559-9571 VBG denotes resuspending
T6348 9572-9579 NN denotes protein
T6349 9580-9588 NNS denotes aliquots
T6350 9589-9591 IN denotes in
T6351 9592-9599 VBG denotes loading
T6352 9600-9606 NN denotes buffer
T6353 9607-9608 -LRB- denotes (
T6354 9608-9611 CD denotes 125
T6355 9612-9614 NNP denotes mM
T6356 9615-9619 NNP denotes Tris
T6357 9620-9623 NNP denotes HCl
T6358 9623-9624 , denotes ,
T6359 9625-9627 NNP denotes pH
T6360 9628-9631 CD denotes 6.8
T6361 9631-9632 , denotes ,
T6362 9633-9634 CD denotes 5
T6363 9634-9635 NN denotes %
T6364 9636-9639 NNP denotes SDS
T6365 9639-9640 , denotes ,
T6366 9641-9642 CD denotes 1
T6367 9642-9643 NN denotes %
T6368 9644-9655 NN denotes bromophenol
T6369 9656-9660 JJ denotes blue
T6370 9660-9661 , denotes ,
T6371 9662-9664 CD denotes 10
T6372 9664-9665 NN denotes %
T6373 9666-9683 NN denotes β-mercaptoethanol
T6374 9683-9684 , denotes ,
T6375 9685-9687 CD denotes 25
T6376 9687-9688 NN denotes %
T6377 9689-9697 NN denotes glycerol
T6378 9697-9698 -RRB- denotes )
T6379 9698-9699 , denotes ,
T6380 9700-9708 VBN denotes resolved
T6381 9709-9711 IN denotes on
T6382 9712-9714 CD denotes 12
T6383 9714-9715 NN denotes %
T6384 9716-9719 NNP denotes SDS
T6385 9720-9724 NNP denotes PAGE
T6386 9724-9725 , denotes ,
T6387 9726-9737 VBD denotes transferred
T6388 9738-9740 TO denotes to
T6389 9741-9755 VB denotes polyvinylidene
T6390 9756-9766 NN denotes difluoride
T6391 9767-9775 NN denotes membrane
T6392 9776-9777 -LRB- denotes (
T6393 9777-9786 NNP denotes Millipore
T6394 9786-9787 , denotes ,
T6395 9788-9795 NNP denotes Bedford
T6396 9795-9796 , denotes ,
T6397 9797-9799 NNP denotes MA
T6398 9799-9800 , denotes ,
T6399 9801-9804 NNP denotes USA
T6400 9804-9805 -RRB- denotes )
T6401 9806-9809 CC denotes and
T6402 9810-9819 VBN denotes incubated
T6403 9820-9824 IN denotes with
T6404 9825-9832 JJ denotes primary
T6405 9833-9843 NNS denotes antibodies
T6406 9844-9845 -LRB- denotes (
T6407 9845-9851 CD denotes 1:1000
T6408 9851-9852 -RRB- denotes )
T6409 9853-9861 VBN denotes followed
T6410 9862-9864 IN denotes by
T6411 9865-9875 NN denotes incubation
T6412 9876-9880 IN denotes with
T6413 9881-9910 JJ denotes horseradish-peroxidase-linked
T6414 9911-9916 NN denotes mouse
T6415 9917-9919 CC denotes or
T6416 9920-9926 NN denotes rabbit
T6417 9927-9930 NNP denotes IgG
T6418 9931-9932 -LRB- denotes (
T6419 9932-9938 CD denotes 1:2000
T6420 9938-9939 -RRB- denotes )
T6421 9940-9941 -LRB- denotes (
T6422 9941-9943 NNP denotes GE
T6423 9944-9954 NNP denotes Healthcare
T6424 9955-9963 NNP denotes Amersham
T6425 9963-9964 , denotes ,
T6426 9965-9971 NNP denotes Little
T6427 9972-9980 NNP denotes Chalfont
T6428 9980-9981 , denotes ,
T6429 9982-9997 NNP denotes Buckinghamshire
T6430 9997-9998 , denotes ,
T6431 9999-10001 NNP denotes UK
T6432 10001-10002 -RRB- denotes )
T6433 10003-10005 IN denotes in
T6434 10006-10009 NNP denotes PBS
T6435 10010-10020 VBG denotes containing
T6436 10021-10022 CD denotes 5
T6437 10022-10023 NN denotes %
T6438 10024-10031 JJ denotes non-fat
T6439 10032-10035 JJ denotes dry
T6440 10036-10040 NN denotes milk
T6441 10041-10042 -LRB- denotes (
T6442 10042-10049 NNP denotes Bio-Rad
T6443 10050-10062 NNPS denotes Laboratories
T6444 10062-10063 -RRB- denotes )
T6445 10063-10064 . denotes .
T6446 10065-10073 NNPS denotes Proteins
T6447 10074-10078 VBD denotes were
T6448 10079-10087 VBN denotes detected
T6449 10088-10090 IN denotes by
T6450 10091-10108 NN denotes chemiluminescence
T6451 10109-10114 VBG denotes using
T6452 10115-10118 DT denotes the
T6453 10119-10122 NNP denotes ECL
T6454 10123-10129 NNP denotes System
T6455 10130-10131 -LRB- denotes (
T6456 10131-10133 NNP denotes GE
T6457 10134-10144 NNP denotes Healthcare
T6458 10145-10153 NNP denotes Amersham
T6459 10153-10154 -RRB- denotes )
T6460 10154-10155 . denotes .
T6461 10156-10163 JJ denotes Primary
T6462 10164-10174 NNS denotes antibodies
T6463 10175-10179 VBD denotes were
T6464 10180-10189 VBN denotes purchased
T6465 10190-10194 IN denotes from
T6466 10194-10195 : denotes :
T6467 10196-10201 NNP denotes Santa
T6468 10202-10206 NNP denotes Cruz
T6469 10207-10220 NNP denotes Biotechnology
T6470 10220-10221 , denotes ,
T6471 10222-10227 NNP denotes Santa
T6472 10228-10232 NNP denotes Cruz
T6473 10232-10233 , denotes ,
T6474 10234-10236 NNP denotes CA
T6475 10236-10237 , denotes ,
T6476 10238-10241 NNP denotes USA
T6477 10242-10243 -LRB- denotes (
T6478 10243-10250 JJ denotes anti-HA
T6479 10251-10253 NNP denotes F7
T6480 10253-10254 , denotes ,
T6481 10255-10265 NNP denotes anti-IκB-α
T6482 10266-10269 NNP denotes C15
T6483 10269-10270 , denotes ,
T6484 10271-10283 JJ denotes anti-Histone
T6485 10284-10286 NNP denotes H1
T6486 10286-10287 , denotes ,
T6487 10288-10306 NNP denotes anti-Hexokinase-II
T6488 10306-10307 -RRB- denotes )
T6489 10307-10308 : denotes ;
T6490 10309-10322 NNP denotes Sigma-Aldrich
T6491 10323-10324 -LRB- denotes (
T6492 10324-10333 JJ denotes anti-FLAG
T6493 10334-10336 NN denotes M2
T6494 10336-10337 , denotes ,
T6495 10338-10352 JJ denotes anti-γ-Tubulin
T6496 10352-10353 -RRB- denotes )
T6497 10353-10354 : denotes ;
T6498 10355-10362 NNP denotes Upstate
T6499 10362-10363 , denotes ,
T6500 10364-10368 NNP denotes Lake
T6501 10369-10375 NNP denotes Placid
T6502 10375-10376 , denotes ,
T6503 10377-10379 NNP denotes NY
T6504 10379-10380 , denotes ,
T6505 10381-10384 NNP denotes USA
T6506 10385-10386 -LRB- denotes (
T6507 10386-10394 JJ denotes anti-p65
T6508 10394-10395 -RRB- denotes )
T6509 10395-10396 . denotes .
T6510 10397-10409 NNP denotes Densitometry
T6511 10410-10412 IN denotes of
T6512 10413-10419 JJ denotes single
T6513 10420-10425 NNS denotes bands
T6514 10426-10429 VBD denotes was
T6515 10430-10438 VBN denotes analysed
T6516 10439-10441 IN denotes by
T6517 10442-10448 NNP denotes ImageJ
T6518 10449-10457 NN denotes software
T6519 10458-10465 NN denotes package
T6520 10466-10467 -LRB- denotes (
T6521 10467-10470 NNP denotes NIH
T6522 10470-10471 , denotes ,
T6523 10472-10475 NNP denotes USA
T6524 10475-10476 -RRB- denotes )
T6525 10476-10477 . denotes .
T6526 10478-10481 NNP denotes IKK
T6527 10482-10490 NN denotes activity
T6528 10491-10494 VBD denotes was
T6529 10495-10504 VBN denotes evaluated
T6530 10505-10507 IN denotes in
T6531 10508-10517 JJ denotes cytosolic
T6532 10518-10526 NNS denotes extracts
T6533 10527-10532 VBG denotes using
T6534 10533-10536 DT denotes the
T6535 10537-10543 NNP denotes HTScan
T6536 10544-10547 NNP denotes IKK
T6537 10548-10554 NN denotes kinase
T6538 10555-10560 NN denotes assay
T6539 10561-10564 NN denotes kit
T6540 10565-10566 -LRB- denotes (
T6541 10566-10570 NNP denotes Cell
T6542 10571-10580 NNP denotes Signaling
T6543 10581-10591 NNP denotes Technology
T6544 10591-10592 , denotes ,
T6545 10593-10600 NNP denotes Danvers
T6546 10600-10601 , denotes ,
T6547 10602-10604 NNP denotes MA
T6548 10604-10605 , denotes ,
T6549 10606-10609 NNP denotes USA
T6550 10609-10610 -RRB- denotes )
T6551 10610-10611 . denotes .
T6552 10612-10619 VBG denotes Binding
T6553 10620-10622 IN denotes of
T6554 10623-10626 CD denotes p65
T6555 10626-10627 , denotes ,
T6556 10628-10631 CD denotes p50
T6557 10632-10635 CC denotes and
T6558 10636-10644 NNP denotes FLAG-Tat
T6559 10645-10647 TO denotes to
T6560 10648-10651 DT denotes the
T6561 10652-10667 JJ denotes double-stranded
T6562 10668-10673 NN denotes NF-κB
T6563 10674-10689 NN denotes oligonucleotide
T6564 10690-10693 VBD denotes was
T6565 10694-10702 VBN denotes measured
T6566 10703-10708 VBG denotes using
T6567 10709-10714 NNP denotes NF-κB
T6568 10715-10720 NNP denotes Combo
T6569 10721-10734 NNP denotes Transcription
T6570 10735-10741 NNP denotes Factor
T6571 10742-10747 NNP denotes Assay
T6572 10748-10751 NN denotes kit
T6573 10752-10753 -LRB- denotes (
T6574 10753-10759 NNP denotes Cayman
T6575 10760-10768 NNP denotes Chemical
T6576 10769-10776 NNP denotes Company
T6577 10776-10777 , denotes ,
T6578 10778-10781 NNP denotes Ann
T6579 10782-10787 NNP denotes Arbor
T6580 10787-10788 , denotes ,
T6581 10789-10791 NNP denotes MI
T6582 10791-10792 , denotes ,
T6583 10793-10796 NNP denotes USA
T6584 10796-10797 -RRB- denotes )
T6585 10797-10798 . denotes .
T6586 10799-10814 NNP denotes Electrophoretic
T6587 10815-10823 NNP denotes Mobility
T6588 10824-10829 NNP denotes Shift
T6589 10830-10835 NNP denotes Assay
T6590 10836-10837 -LRB- denotes (
T6591 10837-10841 NNP denotes EMSA
T6592 10841-10842 -RRB- denotes )
T6593 10843-10846 VBD denotes was
T6594 10847-10856 VBN denotes performed
T6595 10857-10859 IN denotes as
T6596 10860-10870 RB denotes previously
T6597 10871-10880 VBN denotes described
T6598 10881-10882 -LRB- denotes (
T6599 10882-10884 CD denotes 55
T6600 10884-10885 -RRB- denotes )
T6601 10885-10886 : denotes ;
T6602 10887-10894 NNS denotes details
T6603 10895-10898 VBP denotes are
T6604 10899-10908 VBN denotes described
T6605 10909-10911 IN denotes in
T6606 10912-10925 NNP denotes Supplementary
T6607 10926-10930 NNP denotes Data
T6608 10930-10931 . denotes .
T6765 10933-10935 IN denotes In
T6766 10936-10941 NN denotes vitro
T6767 10942-10953 NN denotes translation
T6768 10954-10962 NNP denotes HA-IκB-α
T6769 10962-10963 , denotes ,
T6770 10964-10967 CD denotes p65
T6771 10968-10971 CC denotes and
T6772 10972-10975 NNP denotes Tat
T6773 10976-10980 VBD denotes were
T6774 10981-10990 VBN denotes expressed
T6775 10991-10996 IN denotes under
T6776 10997-11000 DT denotes the
T6777 11001-11003 CD denotes T7
T6778 11004-11012 NN denotes promoter
T6779 11013-11016 CC denotes and
T6780 11017-11019 IN denotes in
T6781 11020-11025 NN denotes vitro
T6782 11026-11036 VBN denotes translated
T6783 11037-11042 VBG denotes using
T6784 11043-11046 DT denotes the
T6785 11047-11050 NNP denotes TnT
T6786 11051-11056 JJ denotes quick
T6787 11057-11064 VBN denotes coupled
T6788 11065-11090 NN denotes transcription/translation
T6789 11091-11097 NN denotes system
T6790 11098-11099 -LRB- denotes (
T6791 11099-11106 NNP denotes Promega
T6792 11106-11107 -RRB- denotes )
T6793 11107-11108 , denotes ,
T6794 11109-11111 IN denotes as
T6795 11112-11122 RB denotes previously
T6796 11123-11131 VBN denotes reported
T6797 11132-11133 -LRB- denotes (
T6798 11133-11135 CD denotes 50
T6799 11135-11136 -RRB- denotes )
T6800 11136-11137 . denotes .
T6801 11138-11145 NNS denotes Details
T6802 11146-11149 VBP denotes are
T6803 11150-11159 VBN denotes described
T6804 11160-11162 IN denotes in
T6805 11163-11176 NNP denotes Supplementary
T6806 11177-11181 NNP denotes Data
T6807 11181-11182 . denotes .
T6916 11184-11203 NNP denotes Immunoprecipitation
T6917 11204-11209 NN denotes assay
T6918 11210-11213 CC denotes and
T6919 11214-11222 NNP denotes GST-pull
T6920 11223-11227 IN denotes down
T6921 11228-11247 NNP denotes Immunoprecipitation
T6922 11247-11248 , denotes ,
T6923 11249-11257 NNP denotes GST-pull
T6924 11258-11262 RB denotes down
T6925 11262-11263 , denotes ,
T6926 11264-11267 CC denotes and
T6927 11268-11278 NN denotes production
T6928 11279-11281 IN denotes of
T6929 11282-11285 NNP denotes GST
T6930 11286-11294 NNS denotes proteins
T6931 11295-11297 IN denotes in
T6932 11298-11309 NNP denotes Escherichia
T6933 11310-11314 NNS denotes coli
T6934 11315-11321 VBP denotes strain
T6935 11322-11326 CD denotes BL21
T6936 11327-11331 VBD denotes were
T6937 11332-11341 VBN denotes performed
T6938 11342-11344 IN denotes as
T6939 11345-11355 RB denotes previously
T6940 11356-11364 VBN denotes reported
T6941 11365-11366 -LRB- denotes (
T6942 11366-11368 CD denotes 50
T6943 11368-11369 -RRB- denotes )
T6944 11369-11370 . denotes .
T6945 11371-11378 NNS denotes Details
T6946 11379-11382 VBP denotes are
T6947 11383-11392 VBN denotes described
T6948 11393-11395 IN denotes in
T6949 11396-11409 NNP denotes Supplementary
T6950 11410-11414 NNP denotes Data
T6951 11414-11415 . denotes .
T7201 11417-11426 JJ denotes Real-time
T7202 11427-11430 NNP denotes PCR
T7203 11431-11436 NNP denotes Total
T7204 11437-11440 NNP denotes RNA
T7205 11441-11444 VBD denotes was
T7206 11445-11454 VBN denotes extracted
T7207 11455-11459 IN denotes from
T7208 11460-11465 NNS denotes cells
T7209 11466-11468 IN denotes by
T7210 11469-11474 VBG denotes using
T7211 11475-11478 DT denotes the
T7212 11479-11485 NNP denotes TRIzol
T7213 11486-11493 NN denotes reagent
T7214 11494-11495 -LRB- denotes (
T7215 11495-11505 NNP denotes Invitrogen
T7216 11505-11506 -RRB- denotes )
T7217 11506-11507 : denotes ;
T7218 11508-11511 NNP denotes RNA
T7219 11512-11520 NNS denotes aliquots
T7220 11521-11522 -LRB- denotes (
T7221 11522-11525 CD denotes 200
T7222 11526-11528 NN denotes ng
T7223 11528-11529 -RRB- denotes )
T7224 11530-11534 VBD denotes were
T7225 11535-11542 RB denotes reverse
T7226 11543-11554 VBN denotes transcribed
T7227 11555-11560 VBG denotes using
T7228 11561-11567 NNP denotes Random
T7229 11568-11575 NNP denotes Examers
T7230 11576-11577 -LRB- denotes (
T7231 11577-11582 NNP denotes Roche
T7232 11582-11583 -RRB- denotes )
T7233 11584-11587 CC denotes and
T7234 11588-11599 NNP denotes Superscript
T7235 11600-11603 NNP denotes III
T7236 11604-11611 VB denotes Reverse
T7237 11612-11625 NNP denotes Transcriptase
T7238 11626-11627 -LRB- denotes (
T7239 11627-11637 NNP denotes Invitrogen
T7240 11637-11638 -RRB- denotes )
T7241 11638-11639 , denotes ,
T7242 11640-11649 VBG denotes according
T7243 11650-11652 TO denotes to
T7244 11653-11656 DT denotes the
T7245 11657-11669 NN denotes manufacturer
T7246 11669-11671 POS denotes 's
T7247 11672-11680 NN denotes protocol
T7248 11680-11681 . denotes .
T7249 11682-11691 JJ denotes Real-time
T7250 11692-11695 NNP denotes PCR
T7251 11696-11699 VBD denotes was
T7252 11700-11709 VBN denotes performed
T7253 11710-11714 IN denotes with
T7254 11715-11718 DT denotes the
T7255 11719-11721 NNP denotes iQ
T7256 11722-11727 NNP denotes Green
T7257 11728-11733 NNP denotes Super
T7258 11734-11737 NN denotes mix
T7259 11738-11739 -LRB- denotes (
T7260 11739-11746 NNP denotes Bio-Rad
T7261 11747-11759 NNPS denotes Laboratories
T7262 11759-11760 -RRB- denotes )
T7263 11761-11764 CC denotes and
T7264 11765-11772 VBD denotes carried
T7265 11773-11776 RP denotes out
T7266 11777-11781 IN denotes with
T7267 11782-11785 DT denotes the
T7268 11786-11793 NNP denotes iCycler
T7269 11794-11796 NNP denotes iQ
T7270 11797-11806 NNP denotes Real-Time
T7271 11807-11816 NN denotes detection
T7272 11817-11823 NN denotes system
T7273 11824-11825 -LRB- denotes (
T7274 11825-11832 NNP denotes Bio-Rad
T7275 11833-11845 NNPS denotes Laboratories
T7276 11845-11846 -RRB- denotes )
T7277 11847-11852 IN denotes under
T7278 11853-11856 DT denotes the
T7279 11857-11866 JJ denotes following
T7280 11867-11877 NNS denotes conditions
T7281 11877-11878 : denotes :
T7282 11879-11881 CD denotes 95
T7283 11881-11882 NN denotes °
T7284 11882-11883 NNP denotes C
T7285 11883-11884 , denotes ,
T7286 11885-11886 CD denotes 1
T7287 11887-11890 NN denotes min
T7288 11890-11891 : denotes ;
T7289 11892-11893 -LRB- denotes (
T7290 11893-11895 CD denotes 94
T7291 11895-11896 NN denotes °
T7292 11896-11897 NNP denotes C
T7293 11897-11898 , denotes ,
T7294 11899-11901 CD denotes 10
T7295 11902-11903 PRP denotes s
T7296 11903-11904 : denotes ;
T7297 11905-11907 CD denotes 60
T7298 11907-11908 NN denotes °
T7299 11908-11909 NNP denotes C
T7300 11909-11910 , denotes ,
T7301 11911-11913 CD denotes 30
T7302 11914-11915 PRP denotes s
T7303 11915-11916 -RRB- denotes )
T7304 11917-11918 RB denotes ×
T7305 11918-11920 CD denotes 40
T7306 11920-11921 . denotes .
T7307 11922-11929 NNS denotes Primers
T7308 11930-11933 IN denotes for
T7309 11934-11937 NNP denotes Tat
T7310 11938-11941 CC denotes and
T7311 11942-11948 NNP denotes MIP-1α
T7312 11949-11952 VBP denotes are
T7313 11953-11959 VBN denotes listed
T7314 11960-11962 IN denotes in
T7315 11963-11976 NNP denotes Supplementary
T7316 11977-11981 NNP denotes Data
T7317 11981-11982 . denotes .
T7318 11983-11992 JJ denotes Real-time
T7319 11993-11996 NNP denotes PCR
T7320 11997-11999 IN denotes of
T7321 12000-12004 NNP denotes CSF3
T7322 12004-12005 , denotes ,
T7323 12006-12009 NNP denotes LTA
T7324 12009-12010 , denotes ,
T7325 12011-12017 NNP denotes NFKBIA
T7326 12017-12018 , denotes ,
T7327 12019-12023 NNP denotes TLR2
T7328 12023-12024 , denotes ,
T7329 12025-12030 NNP denotes GAPDH
T7330 12031-12034 CC denotes and
T7331 12035-12039 NNP denotes ACTB
T7332 12040-12043 VBD denotes was
T7333 12044-12053 VBN denotes performed
T7334 12054-12059 VBG denotes using
T7335 12060-12063 DT denotes the
T7336 12064-12067 NNP denotes RT2
T7337 12068-12076 NN denotes profiler
T7338 12077-12080 NNP denotes PCR
T7339 12081-12092 NNP denotes Array-Human
T7340 12093-12098 NNP denotes NF-κB
T7341 12099-12108 VBG denotes signaling
T7342 12109-12116 NN denotes pathway
T7343 12117-12118 -LRB- denotes (
T7344 12118-12124 NNP denotes QIAGEN
T7345 12125-12133 NNPS denotes Sciences
T7346 12133-12134 , denotes ,
T7347 12135-12137 NNP denotes MD
T7348 12137-12138 , denotes ,
T7349 12139-12142 NNP denotes USA
T7350 12142-12143 -RRB- denotes )
T7351 12143-12144 . denotes .
T7352 12145-12154 NNS denotes Reactions
T7353 12155-12159 VBD denotes were
T7354 12160-12167 VBN denotes carried
T7355 12168-12171 RP denotes out
T7356 12172-12174 IN denotes in
T7357 12175-12185 NN denotes triplicate
T7358 12185-12186 , denotes ,
T7359 12187-12190 CC denotes and
T7360 12191-12195 NN denotes gene
T7361 12196-12206 NN denotes expression
T7362 12207-12213 NNS denotes levels
T7363 12214-12218 VBD denotes were
T7364 12219-12229 VBN denotes calculated
T7365 12230-12238 JJ denotes relative
T7366 12239-12241 TO denotes to
T7367 12242-12247 NNP denotes GAPDH
T7368 12248-12252 NNP denotes mRNA
T7369 12253-12259 NNS denotes levels
T7370 12260-12262 IN denotes as
T7371 12263-12273 JJ denotes endogenous
T7372 12274-12281 NN denotes control
T7373 12281-12282 . denotes .
T7374 12283-12291 JJ denotes Relative
T7375 12292-12302 NN denotes expression
T7376 12303-12306 VBD denotes was
T7377 12307-12317 VBN denotes calculated
T7378 12318-12320 IN denotes as
T7379 12321-12322 CD denotes 2
T7380 12322-12323 -LRB- denotes (
T7381 12323-12325 NN denotes Ct
T7382 12326-12330 NN denotes gene
T7383 12331-12336 IN denotes under
T7384 12337-12350 NN denotes investigation
T7385 12351-12352 NN denotes −
T7386 12353-12355 NNP denotes Ct
T7387 12356-12361 NNP denotes GAPDH
T7388 12361-12362 -RRB- denotes )
T7389 12362-12363 . denotes .
T7546 12365-12374 NNP denotes Chromatin
T7547 12375-12394 NN denotes immunoprecipitation
T7548 12395-12400 NN denotes assay
T7549 12401-12406 NNS denotes Cells
T7550 12407-12411 VBD denotes were
T7551 12412-12417 VBN denotes fixed
T7552 12418-12420 IN denotes by
T7553 12421-12427 VBG denotes adding
T7554 12428-12440 NN denotes formaldehyde
T7555 12441-12442 -LRB- denotes (
T7556 12442-12455 NNP denotes Sigma-Aldrich
T7589 12610-12613 NNP denotes PBS
T7590 12613-12614 , denotes ,
T7591 12615-12618 CC denotes and
T7592 12619-12626 VBD denotes scraped
T7593 12626-12627 . denotes .
T7594 12628-12633 IN denotes After
T7595 12634-12648 NN denotes centrifugation
T7596 12648-12649 , denotes ,
T7597 12650-12655 NNS denotes cells
T7598 12656-12660 VBD denotes were
T7599 12661-12663 CD denotes 10
T7600 12664-12667 NN denotes min
T7601 12668-12673 VBN denotes lysed
T7602 12674-12676 IN denotes in
T7603 12677-12682 NN denotes lysis
T7604 12683-12689 NN denotes buffer
T7605 12690-12691 -LRB- denotes (
T7606 12691-12692 CD denotes 5
T7607 12693-12695 NNP denotes mM
T7608 12696-12701 NNP denotes PIPES
T7609 12702-12704 NNP denotes pH
T7610 12705-12708 CD denotes 8.0
T7611 12708-12709 , denotes ,
T7612 12710-12712 CD denotes 85
T7613 12713-12715 NNP denotes mM
T7614 12716-12719 NNP denotes KCl
T7615 12719-12720 , denotes ,
T7616 12721-12724 CD denotes 0.5
T7617 12724-12725 NN denotes %
T7618 12726-12731 NN denotes NP-40
T7619 12731-12732 -RRB- denotes )
T7620 12733-12745 VBN denotes supplemented
T7621 12746-12750 IN denotes with
T7622 12751-12752 CD denotes 1
T7623 12752-12753 CD denotes ×
T7624 12754-12762 JJ denotes Complete
T7625 12763-12771 NNP denotes Protease
T7626 12772-12781 NNP denotes Inhibitor
T7627 12782-12783 -LRB- denotes (
T7628 12783-12788 NNP denotes Roche
T7629 12789-12799 NNP denotes Diagnostic
T7630 12800-12804 NNP denotes GmbH
T7631 12804-12805 -RRB- denotes )
T7632 12805-12806 . denotes .
T7633 12807-12813 NNP denotes Nuclei
T7634 12814-12818 VBD denotes were
T7635 12819-12828 VBN denotes pelletted
T7636 12829-12830 -LRB- denotes (
T7637 12830-12834 CD denotes 1000
T7638 12835-12836 NN denotes ×
T7639 12837-12838 NN denotes g
T7640 12838-12839 , denotes ,
T7641 12840-12841 CD denotes 5
T7642 12842-12845 NN denotes min
T7643 12845-12846 -RRB- denotes )
T7644 12846-12847 , denotes ,
T7645 12848-12851 CC denotes and
T7646 12852-12863 VBD denotes resuspended
T7647 12864-12866 IN denotes in
T7648 12867-12877 NN denotes sonication
T7649 12878-12884 NN denotes buffer
T7650 12885-12886 -LRB- denotes (
T7651 12886-12888 CD denotes 50
T7652 12889-12891 NNP denotes mM
T7653 12892-12896 NNP denotes Tris
T7654 12897-12900 NNP denotes HCl
T7655 12901-12903 NNP denotes pH
T7656 12904-12907 CD denotes 8.0
T7657 12907-12908 , denotes ,
T7658 12909-12910 CD denotes 1
T7659 12910-12911 NN denotes %
T7660 12912-12915 NNP denotes SDS
T7661 12915-12916 , denotes ,
T7662 12917-12919 CD denotes 10
T7663 12920-12922 NNP denotes mM
T7664 12923-12927 NNP denotes EDTA
T7665 12927-12928 -RRB- denotes )
T7666 12928-12929 . denotes .
T7667 12930-12939 NNP denotes Chromatin
T7668 12940-12943 VBD denotes was
T7669 12944-12953 VBN denotes sonicated
T7670 12954-12959 VBG denotes using
T7671 12960-12968 NNP denotes Bandelin
T7672 12969-12977 NNPS denotes Sonoplus
T7673 12978-12982 NNP denotes GM70
T7674 12983-12984 -LRB- denotes (
T7675 12984-12992 NNP denotes Bandelin
T7676 12993-13003 NNP denotes Electronic
T7677 13003-13004 , denotes ,
T7678 13005-13011 NNP denotes Berlin
T7679 13011-13012 , denotes ,
T7680 13013-13020 NNP denotes Germany
T7681 13020-13021 -RRB- denotes )
T7682 13021-13022 , denotes ,
T7683 13023-13034 VBN denotes centrifuged
T7684 13035-13036 -LRB- denotes (
T7685 13036-13038 CD denotes 14
T7686 13039-13042 CD denotes 000
T7687 13043-13044 NN denotes ×
T7688 13045-13046 NN denotes g
T7689 13046-13047 , denotes ,
T7690 13048-13050 CD denotes 15
T7691 13051-13054 NN denotes min
T7692 13054-13055 -RRB- denotes )
T7693 13055-13056 , denotes ,
T7694 13057-13060 CC denotes and
T7695 13061-13072 NN denotes supernatant
T7696 13073-13076 VBD denotes was
T7697 13077-13084 JJ denotes 10-fold
T7698 13085-13092 VBN denotes diluted
T7699 13093-13095 IN denotes in
T7700 13096-13104 NN denotes dilution
T7701 13105-13111 NN denotes buffer
T7702 13112-13113 -LRB- denotes (
T7703 13113-13117 CD denotes 0.01
T7704 13117-13118 NN denotes %
T7705 13119-13122 NNP denotes SDS
T7706 13122-13123 , denotes ,
T7707 13124-13128 CD denotes 16.7
T7708 13129-13131 NNP denotes mM
T7709 13132-13136 NNP denotes Tris
T7710 13137-13140 NNP denotes HCl
T7711 13141-13143 NNP denotes pH
T7712 13144-13147 CD denotes 8.0
T7713 13147-13148 , denotes ,
T7714 13149-13152 CD denotes 1.1
T7715 13152-13153 NN denotes %
T7716 13154-13160 NNP denotes Triton
T7717 13161-13166 NNP denotes X-100
T7718 13166-13167 , denotes ,
T7719 13168-13171 CD denotes 167
T7720 13172-13174 NNP denotes mM
T7721 13175-13179 NNP denotes NaCl
T7722 13179-13180 , denotes ,
T7723 13181-13184 CD denotes 1.2
T7724 13185-13187 NNP denotes mM
T7725 13188-13192 NNP denotes EDTA
T7726 13192-13193 -RRB- denotes )
T7727 13193-13194 . denotes .
T7728 13195-13202 NNS denotes Samples
T7729 13203-13207 VBD denotes were
T7730 13208-13219 JJ denotes pre-cleared
T7731 13220-13222 IN denotes by
T7732 13223-13226 JJ denotes 3-h
T7733 13227-13237 NN denotes incubation
T7734 13238-13242 IN denotes with
T7735 13243-13245 CD denotes 20
T7736 13246-13248 NN denotes µl
T7737 13249-13251 IN denotes of
T7738 13252-13259 NN denotes protein
T7739 13260-13261 NNP denotes G
T7740 13262-13269 JJ denotes agarose
T7741 13270-13275 NNS denotes beads
T7742 13276-13284 VBN denotes followed
T7743 13285-13287 IN denotes by
T7744 13288-13298 NN denotes incubation
T7745 13299-13303 IN denotes with
T7746 13304-13314 NNS denotes antibodies
T7747 13315-13322 IN denotes against
T7748 13323-13326 DT denotes the
T7749 13327-13335 JJ denotes analysed
T7750 13336-13344 NNS denotes proteins
T7751 13344-13345 . denotes .
T7752 13346-13353 JJ denotes Primary
T7753 13354-13364 NNS denotes antibodies
T7754 13365-13369 VBD denotes were
T7755 13369-13370 : denotes :
T7756 13371-13379 JJ denotes anti-p65
T7757 13380-13381 -LRB- denotes (
T7758 13381-13387 JJ denotes sc-372
T7759 13387-13388 -RRB- denotes )
T7760 13388-13389 , denotes ,
T7761 13390-13399 JJ denotes anti-IκBα
T7762 13400-13401 -LRB- denotes (
T7763 13401-13407 JJ denotes sc-203
T7764 13407-13408 -RRB- denotes )
T7765 13409-13412 CC denotes and
T7766 13413-13419 NN denotes rabbit
T7767 13420-13423 NNP denotes IgG
T7768 13424-13425 -LRB- denotes (
T7769 13425-13432 JJ denotes sc-2027
T7770 13432-13433 -RRB- denotes )
T7771 13434-13438 IN denotes from
T7772 13439-13444 NNP denotes Santa
T7773 13445-13449 NNP denotes Cruz
T7774 13450-13463 NNP denotes Biotechnology
T7775 13463-13464 : denotes ;
T7776 13465-13474 NNP denotes anti-FLAG
T7777 13475-13477 NNP denotes M2
T7778 13478-13482 IN denotes from
T7779 13483-13488 NNP denotes Sigma
T7780 13489-13496 NNP denotes Aldrich
T7781 13496-13497 . denotes .
T7782 13498-13518 NNS denotes Immunoprecipitations
T7783 13519-13523 VBD denotes were
T7784 13524-13531 VBN denotes carried
T7785 13532-13535 RP denotes out
T7786 13536-13538 IN denotes at
T7787 13539-13540 CD denotes 4
T7788 13540-13541 CD denotes °
T7789 13541-13542 NNP denotes C
T7790 13543-13552 JJ denotes overnight
T7791 13553-13556 CC denotes and
T7792 13557-13563 JJ denotes immune
T7793 13564-13573 NNS denotes complexes
T7794 13574-13578 VBD denotes were
T7795 13579-13588 VBN denotes collected
T7796 13589-13593 IN denotes with
T7797 13594-13601 NN denotes protein
T7798 13602-13603 NNP denotes G
T7799 13604-13611 JJ denotes agarose
T7800 13612-13617 NNS denotes beads
T7801 13617-13618 , denotes ,
T7802 13619-13625 VBD denotes washed
T7803 13626-13630 CD denotes five
T7804 13631-13636 NNS denotes times
T7805 13637-13641 IN denotes with
T7806 13642-13645 JJ denotes low
T7807 13646-13650 NN denotes salt
T7808 13651-13657 NN denotes buffer
T7809 13658-13659 -LRB- denotes (
T7810 13659-13661 CD denotes 20
T7811 13662-13664 NNP denotes mM
T7812 13665-13669 NNP denotes Tris
T7813 13670-13673 NNP denotes HCl
T7814 13674-13676 NNP denotes pH
T7815 13677-13680 CD denotes 8.0
T7816 13680-13681 , denotes ,
T7817 13682-13685 CD denotes 0.1
T7818 13685-13686 NN denotes %
T7819 13687-13690 NNP denotes SDS
T7820 13690-13691 , denotes ,
T7821 13692-13693 CD denotes 1
T7822 13693-13694 NN denotes %
T7823 13695-13701 NNP denotes Triton
T7824 13702-13707 NNP denotes X-100
T7825 13707-13708 , denotes ,
T7826 13709-13710 CD denotes 2
T7827 13711-13713 NNP denotes mM
T7828 13714-13718 NNP denotes EDTA
T7829 13718-13719 , denotes ,
T7830 13720-13723 CD denotes 150
T7831 13724-13726 NNP denotes mM
T7832 13727-13731 NNP denotes NaCl
T7833 13731-13732 -RRB- denotes )
T7834 13732-13733 , denotes ,
T7835 13734-13738 CD denotes four
T7836 13739-13744 NNS denotes times
T7837 13745-13749 IN denotes with
T7838 13750-13754 JJ denotes high
T7839 13755-13759 NN denotes salt
T7840 13760-13766 NN denotes buffer
T7841 13767-13768 -LRB- denotes (
T7842 13768-13770 CD denotes 20
T7843 13771-13773 NNP denotes mM
T7844 13774-13778 NNP denotes Tris
T7845 13779-13782 NNP denotes HCl
T7846 13783-13785 NNP denotes pH
T7847 13786-13789 CD denotes 8.0
T7848 13789-13790 , denotes ,
T7849 13791-13794 CD denotes 0.1
T7850 13794-13795 NN denotes %
T7851 13796-13799 NNP denotes SDS
T7852 13799-13800 , denotes ,
T7853 13801-13802 CD denotes 1
T7854 13802-13803 NN denotes %
T7855 13804-13810 NNP denotes Triton
T7856 13811-13816 NNP denotes X-100
T7857 13816-13817 , denotes ,
T7858 13818-13819 CD denotes 2
T7859 13820-13822 NNP denotes mM
T7860 13823-13827 NNP denotes EDTA
T7861 13827-13828 , denotes ,
T7862 13829-13832 CD denotes 500
T7863 13833-13835 NNP denotes mM
T7864 13836-13840 NNP denotes NaCl
T7865 13840-13841 -RRB- denotes )
T7866 13841-13842 , denotes ,
T7867 13843-13847 RB denotes once
T7868 13848-13852 IN denotes with
T7869 13853-13855 NNP denotes TE
T7870 13856-13862 NN denotes buffer
T7871 13863-13864 -LRB- denotes (
T7872 13864-13866 CD denotes 10
T7873 13867-13869 NNP denotes mM
T7874 13870-13874 NNP denotes Tris
T7875 13875-13878 NNP denotes HCl
T7876 13879-13881 NNP denotes pH
T7877 13882-13885 CD denotes 8.0
T7878 13885-13886 , denotes ,
T7879 13887-13888 CD denotes 1
T7915 14067-14070 NN denotes kit
T7916 14071-14072 -LRB- denotes (
T7917 14072-14078 NNP denotes QIAGEN
T7918 14078-14079 -RRB- denotes )
T7919 14080-14083 CC denotes and
T7920 14084-14090 VBD denotes eluted
T7921 14091-14093 IN denotes in
T7922 14094-14096 CD denotes 50
T7923 14097-14099 NN denotes µl
T7924 14100-14107 JJ denotes sterile
T7925 14108-14117 JJ denotes distilled
T7926 14118-14123 NN denotes water
T7927 14123-14124 . denotes .
T7928 14125-14133 JJ denotes Specific
T7929 14134-14144 NN denotes enrichment
T7930 14145-14147 IN denotes in
T7931 14148-14153 JJ denotes NF-κB
T7932 14154-14162 NN denotes enhancer
T7933 14163-14172 NNS denotes sequences
T7934 14173-14176 VBD denotes was
T7935 14177-14185 VBN denotes measured
T7936 14186-14188 IN denotes by
T7937 14189-14198 JJ denotes real-time
T7938 14199-14202 NNP denotes PCR
T7939 14203-14205 IN denotes of
T7940 14206-14215 NN denotes chromatin
T7941 14216-14235 NN denotes immunoprecipitation
T7942 14236-14237 -LRB- denotes (
T7943 14237-14241 NNP denotes ChIP
T7944 14241-14242 -RRB- denotes )
T7956 14305-14309 VBD denotes were
T7957 14310-14317 VBN denotes carried
T7958 14318-14321 RP denotes out
T7959 14322-14326 IN denotes with
T7960 14327-14330 DT denotes the
T7961 14331-14338 NNP denotes iCycler
T7962 14339-14341 NNP denotes iQ
T7963 14342-14351 NNP denotes Real-Time
T7964 14352-14361 NN denotes detection
T7965 14362-14368 NN denotes system
T7966 14369-14370 -LRB- denotes (
T7967 14370-14377 NNP denotes Bio-Rad
T7968 14378-14390 NNPS denotes Laboratories
T7969 14390-14391 -RRB- denotes )
T7970 14392-14397 VBG denotes using
T7971 14398-14401 DT denotes the
T7972 14402-14411 JJ denotes following
T7973 14412-14422 NNS denotes conditions
T7974 14422-14423 : denotes :
T7975 14424-14426 CD denotes 95
T7976 14426-14427 NN denotes °
T7977 14427-14428 NNP denotes C
T7978 14428-14429 , denotes ,
T7979 14430-14431 CD denotes 1
T7980 14432-14435 NN denotes min
T7981 14435-14436 : denotes ;
T7982 14437-14438 -LRB- denotes (
T7983 14438-14440 CD denotes 94
T7984 14440-14441 NN denotes °
T7985 14441-14442 NNP denotes C
T7986 14442-14443 , denotes ,
T7987 14444-14446 CD denotes 10
T7988 14447-14448 PRP denotes s
T7989 14448-14449 : denotes ;
T7990 14450-14452 CD denotes 60
T7991 14452-14453 NN denotes °
T7992 14453-14454 NNP denotes C
T7993 14454-14455 , denotes ,
T7994 14456-14458 CD denotes 30
T7995 14459-14460 PRP denotes s
T7996 14460-14461 -RRB- denotes )
T7997 14462-14463 RB denotes ×
T7998 14463-14465 CD denotes 40
T7999 14465-14466 . denotes .
T8000 14467-14474 NNS denotes Primers
T8001 14475-14479 VBD denotes used
T8002 14480-14483 IN denotes for
T8003 14484-14490 NNP denotes MIP-1α
T8004 14490-14491 , denotes ,
T8005 14492-14497 NNP denotes GAPDH
T8006 14498-14501 CC denotes and
T8007 14502-14506 NNP denotes ACTB
T8008 14507-14510 VBP denotes are
T8009 14511-14517 VBN denotes listed
T8010 14518-14520 IN denotes in
T8011 14521-14534 NNP denotes Supplementary
T8012 14535-14539 NNP denotes Data
T8013 14539-14540 . denotes .
T8014 14541-14550 JJ denotes Real-time
T8015 14551-14554 NNP denotes PCR
T8016 14555-14557 IN denotes of
T8017 14558-14562 NNP denotes CSF3
T8018 14562-14563 , denotes ,
T8019 14564-14567 NNP denotes LTA
T8020 14567-14568 , denotes ,
T8021 14569-14575 NNP denotes NFKBIA
T8022 14576-14579 CC denotes and
T8023 14580-14584 CD denotes TLR2
T8024 14585-14589 VBD denotes were
T8025 14590-14599 VBN denotes performed
T8026 14600-14605 VBG denotes using
T8027 14606-14609 DT denotes the
T8028 14610-14616 NNP denotes Custom
T8029 14617-14621 NNP denotes ChIP
T8030 14622-14627 NN denotes array
T8031 14628-14629 -LRB- denotes (
T8032 14629-14635 NNP denotes QIAGEN
T8033 14635-14636 -RRB- denotes )
T8034 14636-14637 . denotes .
T8035 14638-14641 IN denotes For
T8036 14642-14646 DT denotes each
T8037 14647-14653 NN denotes sample
T8038 14653-14654 , denotes ,
T8039 14655-14661 NNS denotes values
T8040 14662-14666 VBD denotes were
T8041 14667-14677 VBN denotes normalized
T8042 14678-14680 TO denotes to
T8043 14681-14686 NN denotes input
T8044 14687-14690 NN denotes DNA
T8045 14691-14694 CC denotes and
T8046 14695-14703 VBD denotes reported
T8047 14704-14706 IN denotes as
T8048 14707-14708 NN denotes %
T8049 14709-14711 IN denotes of
T8050 14712-14717 NN denotes input
T8051 14718-14722 IN denotes over
T8052 14723-14726 DT denotes the
T8053 14727-14733 NN denotes rabbit
T8054 14734-14737 NNP denotes IgG
T8055 14738-14745 NN denotes control
T8056 14745-14746 . denotes .
T8195 14748-14759 NNP denotes Statistical
T8196 14760-14768 NN denotes analysis
T8197 14769-14780 NNP denotes Statistical
T8198 14781-14789 NN denotes analysis
T8199 14790-14793 VBD denotes was
T8200 14794-14803 VBN denotes performed
T8201 14804-14806 IN denotes by
T8202 14807-14815 JJ denotes two-tail
T8203 14816-14824 JJ denotes unpaired
T8204 14825-14832 NN denotes Student
T8205 14832-14834 POS denotes 's
T8206 14835-14841 JJS denotes t-test
T8207 14841-14842 . denotes .
T8208 14843-14847 NNS denotes Data
T8209 14848-14852 VBD denotes were
T8210 14853-14861 VBN denotes reported
T8211 14862-14864 IN denotes as
T8212 14865-14870 NNS denotes means
T8213 14871-14872 VBP denotes ±
T8214 14873-14875 NNP denotes SE
T8215 14875-14876 . denotes .
T8216 14877-14888 NNS denotes Differences
T8217 14889-14896 IN denotes between
T8218 14897-14900 DT denotes the
T8219 14901-14906 NNS denotes means
T8220 14907-14911 VBD denotes were
T8221 14912-14922 VBN denotes considered
T8222 14923-14925 IN denotes as
T8223 14926-14939 RB denotes statistically
T8224 14940-14951 JJ denotes significant
T8225 14952-14954 IN denotes at
T8226 14955-14958 DT denotes the
T8227 14959-14961 CD denotes 95
T8228 14961-14962 NN denotes %
T8229 14963-14968 NN denotes level
T8230 14969-14970 -LRB- denotes (
T8231 14970-14971 NNP denotes P
T8232 14972-14973 CD denotes <
T8233 14974-14978 CD denotes 0.05
T8234 14978-14979 -RRB- denotes )
T8235 14979-14980 . denotes .
T9532 14991-14994 NNP denotes Tat
T9533 14995-15003 VBZ denotes enhances
T9534 15004-15007 DT denotes the
T9535 15008-15013 JJ denotes NF-κB
T9536 15014-15022 NN denotes activity
T9537 15023-15025 IN denotes by
T9538 15026-15035 VBG denotes hijacking
T9539 15036-15041 NNP denotes IκB-α
T9540 15042-15045 CC denotes and
T9541 15046-15056 VBG denotes inhibiting
T9542 15057-15060 DT denotes the
T9543 15061-15076 NN denotes post-activation
T9544 15077-15081 VB denotes turn
T9545 15082-15085 RB denotes off
T9546 15086-15088 IN denotes of
T9547 15089-15094 NNP denotes NF-κB
T9548 15095-15097 PRP denotes We
T9549 15098-15106 VBD denotes analysed
T9550 15107-15110 DT denotes the
T9551 15111-15118 NN denotes kinetic
T9552 15119-15121 IN denotes of
T9553 15122-15127 JJ denotes NF-κB
T9554 15128-15138 NN denotes activation
T9555 15139-15141 IN denotes in
T9556 15142-15148 JJ denotes single
T9557 15149-15154 NN denotes round
T9558 15155-15160 NN denotes HIV-1
T9559 15161-15170 NN denotes infection
T9560 15171-15173 IN denotes by
T9561 15174-15184 VBG denotes modulating
T9562 15185-15188 DT denotes the
T9563 15189-15199 NN denotes expression
T9564 15200-15202 IN denotes of
T9565 15203-15206 NNP denotes Tat
T9566 15207-15211 IN denotes with
T9567 15212-15215 NNP denotes RNA
T9568 15216-15228 NN denotes interference
T9569 15228-15229 . denotes .
T9570 15230-15236 NNP denotes Jurkat
T9571 15237-15242 NNS denotes cells
T9572 15243-15247 VBD denotes were
T9573 15248-15259 VBN denotes transfected
T9574 15260-15264 IN denotes with
T9575 15265-15270 NNP denotes siRNA
T9576 15271-15274 NNP denotes Tat
T9577 15274-15275 , denotes ,
T9578 15276-15281 NNP denotes siRNA
T9579 15282-15289 NN denotes control
T9580 15289-15290 , denotes ,
T9581 15291-15293 CC denotes or
T9582 15294-15298 VBD denotes left
T9583 15299-15312 JJ denotes untransfected
T9584 15312-15313 , denotes ,
T9585 15314-15317 CC denotes and
T9586 15318-15320 CD denotes 24
T9587 15321-15322 NN denotes h
T9588 15323-15328 RB denotes later
T9589 15329-15334 NNS denotes cells
T9590 15335-15339 VBD denotes were
T9591 15340-15348 VBN denotes infected
T9592 15349-15353 IN denotes with
T9593 15354-15358 CD denotes HXB2
T9594 15359-15374 JJ denotes Env-pseudotyped
T9595 15375-15380 NN denotes NL4-3
T9596 15380-15381 . denotes .
T9597 15381-15386 NNP denotes Luc.R
T9598 15386-15387 NNP denotes −
T9599 15387-15388 NNP denotes E
T9600 15388-15389 VBD denotes −
T9601 15390-15397 NNS denotes virions
T9602 15397-15398 . denotes .
T9603 15399-15401 IN denotes By
T9604 15402-15418 JJ denotes cytofluorimetric
T9605 15419-15427 NN denotes analysis
T9606 15427-15428 , denotes ,
T9607 15429-15430 RB denotes ∼
T9608 15430-15432 CD denotes 40
T9609 15432-15433 NN denotes %
T9610 15434-15436 IN denotes of
T9611 15437-15442 NNS denotes cells
T9612 15443-15446 VBD denotes was
T9613 15447-15464 JJ denotes siRNA-transfected
T9614 15465-15468 CC denotes and
T9615 15469-15483 JJ denotes HIV-1-infected
T9616 15484-15486 IN denotes at
T9617 15487-15491 JJ denotes 12-h
T9618 15492-15506 NN denotes post-infection
T9619 15507-15508 -LRB- denotes (
T9620 15508-15521 NNP denotes Supplementary
T9621 15522-15528 NNP denotes Figure
T9622 15529-15531 NNP denotes S1
T9623 15531-15532 -RRB- denotes )
T9624 15532-15533 . denotes .
T9625 15534-15537 DT denotes The
T9626 15538-15548 NN denotes expression
T9627 15549-15551 IN denotes of
T9628 15552-15555 NNP denotes Tat
T9629 15556-15559 VBD denotes was
T9630 15560-15568 VBN denotes detected
T9631 15569-15571 IN denotes at
T9632 15572-15575 JJ denotes 1-h
T9633 15576-15590 NN denotes post-infection
T9634 15591-15594 CC denotes and
T9635 15595-15608 RB denotes progressively
T9636 15609-15618 VBD denotes increased
T9637 15619-15621 RB denotes up
T9638 15622-15624 TO denotes to
T9639 15625-15627 CD denotes 12
T9640 15628-15629 NN denotes h
T9641 15630-15632 IN denotes in
T9642 15633-15646 JJ denotes untransfected
T9643 15647-15650 CC denotes and
T9644 15651-15656 JJ denotes siRNA
T9645 15657-15676 JJ denotes control-transfected
T9646 15677-15682 NNS denotes cells
T9647 15682-15683 , denotes ,
T9648 15684-15689 IN denotes while
T9649 15690-15692 PRP denotes it
T9650 15693-15696 VBD denotes was
T9651 15697-15703 RB denotes barely
T9652 15704-15712 VBN denotes detected
T9653 15713-15715 IN denotes in
T9654 15716-15721 NNP denotes siRNA
T9655 15722-15737 VBD denotes Tat-transfected
T9656 15738-15743 NNS denotes cells
T9657 15744-15745 -LRB- denotes (
T9658 15745-15751 NN denotes Figure
T9659 15752-15754 CD denotes 1A
T9660 15754-15755 -RRB- denotes )
T9661 15755-15756 . denotes .
T9662 15757-15760 DT denotes The
T9663 15761-15774 JJ denotes LTR-dependent
T9664 15775-15785 NN denotes luciferase
T9665 15786-15796 NN denotes expression
T9666 15797-15800 VBD denotes was
T9667 15801-15805 RB denotes also
T9668 15806-15819 RB denotes progressively
T9669 15820-15827 VBD denotes induced
T9670 15828-15830 IN denotes at
T9671 15831-15832 LS denotes 1
T9672 15832-15833 : denotes -
T9673 15834-15836 TO denotes to
T9674 15837-15841 JJ denotes 12-h
T9675 15842-15856 NN denotes post-infection
T9676 15857-15859 IN denotes in
T9677 15860-15873 JJ denotes untransfected
T9678 15874-15877 CC denotes and
T9679 15878-15883 JJ denotes siRNA
T9680 15884-15903 JJ denotes control-transfected
T9681 15904-15909 NNS denotes cells
T9682 15909-15910 , denotes ,
T9683 15911-15916 IN denotes while
T9684 15917-15919 PRP denotes it
T9685 15920-15923 VBD denotes was
T9686 15924-15930 RB denotes barely
T9687 15931-15939 VBN denotes observed
T9688 15940-15942 IN denotes in
T9689 15943-15948 NNP denotes siRNA
T9690 15949-15964 VBD denotes Tat-transfected
T9691 15965-15970 NNS denotes cells
T9692 15970-15971 , denotes ,
T9693 15972-15974 IN denotes as
T9694 15975-15983 VBN denotes expected
T9695 15984-15987 IN denotes for
T9696 15988-15991 DT denotes the
T9697 15992-16005 JJ denotes Tat-dependent
T9698 16006-16021 NN denotes transactivation
T9699 16022-16024 IN denotes of
T9700 16025-16028 DT denotes the
T9701 16029-16034 NNP denotes HIV-1
T9702 16035-16038 NNP denotes LTR
T9703 16039-16040 -LRB- denotes (
T9704 16040-16046 NNP denotes Figure
T9705 16047-16049 NNP denotes 1A
T9706 16049-16050 -RRB- denotes )
T9707 16050-16051 . denotes .
T9708 17245-17248 DT denotes The
T9709 17249-17260 JJ denotes progressive
T9710 17261-17269 NN denotes increase
T9711 17270-17272 IN denotes in
T9712 17273-17278 JJ denotes NF-κB
T9713 17279-17287 NN denotes activity
T9714 17287-17288 , denotes ,
T9715 17289-17291 IN denotes as
T9716 17292-17300 VBN denotes measured
T9717 17301-17303 IN denotes by
T9718 17304-17307 NNS denotes p65
T9719 17308-17311 JJ denotes p50
T9720 17312-17319 JJ denotes binding
T9721 17320-17322 TO denotes to
T9722 17323-17325 DT denotes an
T9723 17326-17331 JJ denotes NF-κB
T9724 17332-17341 NN denotes consensus
T9725 17342-17357 NN denotes oligonucleotide
T9726 17358-17359 -LRB- denotes (
T9727 17359-17365 NN denotes Figure
T9728 17366-17368 NN denotes 1B
T9729 17368-17369 -RRB- denotes )
T9730 17370-17373 CC denotes and
T9731 17374-17381 JJ denotes nuclear
T9732 17382-17385 NNS denotes p65
T9733 17386-17387 -LRB- denotes (
T9734 17387-17393 NN denotes Figure
T9735 17394-17396 CD denotes 1C
T9736 17396-17397 , denotes ,
T9737 17398-17405 NN denotes nucleus
T9738 17405-17406 -RRB- denotes )
T9739 17406-17407 , denotes ,
T9740 17408-17411 VBD denotes was
T9741 17412-17420 VBN denotes observed
T9742 17421-17423 IN denotes at
T9743 17424-17425 LS denotes 1
T9744 17425-17426 : denotes -
T9745 17427-17429 TO denotes to
T9746 17430-17433 JJ denotes 3-h
T9747 17434-17448 NN denotes post-infection
T9748 17449-17451 IN denotes in
T9749 17452-17456 DT denotes both
T9750 17457-17469 JJ denotes Tat-positive
T9751 17470-17471 -LRB- denotes (
T9752 17471-17473 DT denotes no
T9753 17474-17479 NN denotes siRNA
T9754 17480-17482 CC denotes or
T9755 17483-17488 NN denotes siRNA
T9756 17489-17496 NN denotes control
T9757 17496-17497 -RRB- denotes )
T9758 17498-17501 CC denotes and
T9759 17502-17514 JJ denotes Tat-negative
T9760 17515-17516 -LRB- denotes (
T9761 17516-17521 NNP denotes siRNA
T9762 17522-17525 NNP denotes Tat
T9763 17525-17526 -RRB- denotes )
T9764 17527-17532 NNS denotes cells
T9765 17532-17533 : denotes ;
T9766 17534-17541 RB denotes however
T9767 17541-17542 , denotes ,
T9768 17543-17545 IN denotes at
T9769 17546-17550 JJ denotes 12-h
T9770 17551-17565 NN denotes post-infection
T9771 17565-17566 , denotes ,
T9772 17567-17570 DT denotes the
T9773 17571-17574 CD denotes p65
T9774 17575-17578 NNP denotes DNA
T9775 17579-17586 JJ denotes binding
T9776 17587-17590 CC denotes and
T9777 17591-17598 JJ denotes nuclear
T9778 17599-17602 NNS denotes p65
T9779 17603-17612 VBD denotes persisted
T9780 17613-17621 VBN denotes elevated
T9781 17622-17624 IN denotes in
T9782 17625-17633 NN denotes presence
T9783 17634-17636 IN denotes of
T9784 17637-17640 NNP denotes Tat
T9785 17641-17642 -LRB- denotes (
T9786 17642-17644 DT denotes no
T9787 17645-17650 NN denotes siRNA
T9788 17651-17654 CC denotes and
T9789 17655-17660 NN denotes siRNA
T9790 17661-17668 NN denotes control
T9791 17668-17669 -RRB- denotes )
T9792 17669-17670 , denotes ,
T9793 17671-17676 IN denotes while
T9794 17677-17681 PRP denotes they
T9795 17682-17689 VBD denotes dropped
T9796 17690-17692 IN denotes in
T9797 17693-17700 NN denotes absence
T9798 17701-17703 IN denotes of
T9799 17704-17707 NNP denotes Tat
T9800 17708-17709 -LRB- denotes (
T9801 17709-17714 NNP denotes siRNA
T9802 17715-17718 NNP denotes Tat
T9803 17718-17719 -RRB- denotes )
T9804 17720-17721 -LRB- denotes (
T9805 17721-17727 NN denotes Figure
T9806 17728-17730 CD denotes 1B
T9807 17731-17734 CC denotes and
T9808 17735-17736 NNP denotes C
T9809 17736-17737 -RRB- denotes )
T9810 17737-17738 . denotes .
T9811 17739-17744 NN denotes IκB-α
T9812 17745-17748 VBD denotes was
T9813 17749-17757 JJ denotes degraded
T9814 17758-17760 IN denotes in
T9815 17761-17764 DT denotes the
T9816 17765-17772 NN denotes cytosol
T9817 17773-17779 IN denotes within
T9818 17780-17783 JJ denotes 3-h
T9819 17784-17798 NN denotes post-infection
T9820 17799-17802 CC denotes and
T9821 17803-17805 IN denotes de
T9822 17806-17810 JJ denotes novo
T9823 17811-17822 VBN denotes synthesized
T9824 17823-17825 IN denotes at
T9825 17826-17827 CD denotes 6
T9826 17828-17829 NN denotes h
T9827 17830-17834 IN denotes with
T9828 17835-17839 JJ denotes full
T9829 17840-17853 NN denotes replenishment
T9830 17854-17856 IN denotes at
T9831 17857-17861 JJ denotes 12-h
T9832 17862-17876 NN denotes post-infection
T9833 17877-17879 IN denotes in
T9834 17880-17884 DT denotes both
T9835 17885-17897 JJ denotes Tat-positive
T9836 17898-17901 CC denotes and
T9837 17902-17914 JJ denotes Tat-negative
T9838 17915-17920 NNS denotes cells
T9839 17921-17922 -LRB- denotes (
T9840 17922-17928 NN denotes Figure
T9841 17929-17931 CD denotes 1C
T9842 17931-17932 , denotes ,
T9843 17933-17940 NN denotes cytosol
T9844 17940-17941 -RRB- denotes )
T9845 17941-17942 . denotes .
T9846 17943-17955 RB denotes Consistently
T9847 17955-17956 , denotes ,
T9848 17957-17960 DT denotes the
T9849 17961-17964 NNP denotes IKK
T9850 17965-17973 NN denotes activity
T9851 17974-17977 VBD denotes was
T9852 17978-17985 VBN denotes induced
T9853 17986-17988 IN denotes at
T9854 17989-17992 JJ denotes 1-h
T9855 17993-18007 NN denotes post-infection
T9856 18007-18008 , denotes ,
T9857 18009-18012 CC denotes and
T9858 18013-18022 VBD denotes decreased
T9859 18023-18025 IN denotes at
T9860 18026-18029 JJ denotes 3-h
T9861 18030-18044 JJ denotes post-infection
T9862 18045-18058 RB denotes independently
T9863 18059-18061 IN denotes of
T9864 18062-18065 DT denotes the
T9865 18066-18074 NN denotes presence
T9866 18075-18077 IN denotes of
T9867 18078-18081 NNP denotes Tat
T9868 18082-18083 -LRB- denotes (
T9869 18083-18089 NNP denotes Figure
T9870 18090-18092 NNP denotes 1D
T9871 18092-18093 -RRB- denotes )
T9872 18093-18094 . denotes .
T9873 18095-18102 JJ denotes Similar
T9874 18103-18111 NNS denotes kinetics
T9875 18112-18114 IN denotes of
T9876 18115-18120 JJ denotes NF-κB
T9877 18121-18129 NN denotes activity
T9878 18129-18130 , denotes ,
T9879 18131-18134 NNP denotes IKK
T9880 18135-18145 NN denotes activation
T9881 18146-18149 CC denotes and
T9882 18150-18155 JJ denotes IκB-α
T9883 18156-18180 NN denotes degradation/re-synthesis
T9884 18181-18185 VBD denotes were
T9885 18186-18194 VBN denotes observed
T9886 18195-18197 IN denotes in
T9887 18198-18210 JJ denotes single-round
T9888 18211-18216 JJ denotes HIV-1
T9889 18217-18226 NN denotes infection
T9890 18227-18229 IN denotes of
T9891 18230-18235 NNP denotes PBMCs
T9892 18236-18241 VBG denotes using
T9893 18242-18243 DT denotes a
T9894 18244-18252 NN denotes cocktail
T9895 18253-18255 IN denotes of
T9896 18256-18270 NNP denotes Azidothymidine
T9897 18271-18272 -LRB- denotes (
T9898 18272-18275 NNP denotes AZT
T9899 18275-18276 -RRB- denotes )
T9900 18277-18280 CC denotes and
T9901 18281-18291 NNP denotes Lamivudine
T9902 18292-18293 -LRB- denotes (
T9903 18293-18296 NNP denotes 3TC
T9904 18296-18297 -RRB- denotes )
T9905 18298-18300 IN denotes as
T9906 18301-18308 NN denotes reverse
T9907 18309-18322 NN denotes transcriptase
T9908 18323-18333 NNS denotes inhibitors
T9909 18334-18335 -LRB- denotes (
T9910 18335-18348 NNP denotes Supplementary
T9911 18349-18355 NNP denotes Figure
T9912 18356-18358 NNP denotes S2
T9913 18358-18359 -RRB- denotes )
T9914 18359-18360 . denotes .
T9915 18361-18366 DT denotes These
T9916 18367-18374 NNS denotes results
T9917 18375-18384 VBD denotes indicated
T9918 18385-18389 IN denotes that
T9919 18390-18392 IN denotes in
T9920 18393-18405 JJ denotes single-round
T9921 18406-18411 JJ denotes HIV-1
T9922 18412-18421 NN denotes infection
T9923 18422-18425 DT denotes the
T9924 18426-18431 NNP denotes NF-κB
T9925 18432-18442 NN denotes activation
T9926 18443-18452 RB denotes initially
T9927 18453-18463 VBD denotes correlated
T9928 18464-18468 IN denotes with
T9929 18469-18472 DT denotes the
T9930 18473-18476 NNP denotes IKK
T9931 18477-18487 NN denotes activation
T9932 18488-18491 CC denotes and
T9933 18492-18497 JJ denotes IκB-α
T9934 18498-18509 NN denotes degradation
T9935 18510-18523 RB denotes independently
T9936 18524-18526 IN denotes of
T9937 18527-18530 DT denotes the
T9938 18531-18539 NN denotes presence
T9939 18540-18542 IN denotes of
T9940 18543-18546 NNP denotes Tat
T9941 18546-18547 , denotes ,
T9942 18548-18551 CC denotes and
T9943 18552-18554 PRP denotes it
T9944 18555-18558 VBD denotes was
T9945 18559-18563 VBN denotes kept
T9946 18564-18572 VBN denotes elevated
T9947 18573-18575 IN denotes in
T9948 18576-18584 NN denotes presence
T9949 18585-18587 IN denotes of
T9950 18588-18591 NNP denotes Tat
T9951 18592-18601 VBG denotes following
T9952 18602-18605 DT denotes the
T9953 18606-18611 NN denotes decay
T9954 18612-18614 IN denotes of
T9955 18615-18618 DT denotes the
T9956 18619-18622 NNP denotes IKK
T9957 18623-18631 NN denotes activity
T9958 18632-18635 CC denotes and
T9959 18636-18639 JJ denotes new
T9960 18640-18649 NN denotes synthesis
T9961 18650-18652 IN denotes of
T9962 18653-18658 NNP denotes IκB-α
T9963 18658-18659 . denotes .
T9964 18660-18664 JJ denotes Next
T9965 18664-18665 , denotes ,
T9966 18666-18668 PRP denotes we
T9967 18669-18675 VBD denotes tested
T9968 18676-18679 DT denotes the
T9969 18680-18686 JJ denotes single
T9970 18687-18693 NN denotes action
T9971 18694-18696 IN denotes of
T9972 18697-18700 NNP denotes Tat
T9973 18701-18703 IN denotes on
T9974 18704-18707 DT denotes the
T9975 18708-18715 NN denotes kinetic
T9976 18716-18718 IN denotes of
T9977 18719-18724 JJ denotes NF-κB
T9978 18725-18733 NN denotes activity
T9979 18734-18741 VBN denotes induced
T9980 18742-18744 IN denotes by
T9981 18745-18748 NNP denotes PMA
T9982 18748-18749 . denotes .
T9983 18750-18752 TO denotes To
T9984 18753-18757 DT denotes this
T9985 18758-18761 NN denotes end
T9986 18761-18762 , denotes ,
T9987 18763-18767 NNP denotes HeLa
T9988 18768-18773 NNS denotes cells
T9989 18774-18778 VBD denotes were
T9990 18779-18790 VBN denotes transfected
T9991 18791-18795 IN denotes with
T9992 18796-18808 NN denotes p3x-FLAG-Tat
T9993 18808-18809 , denotes ,
T9994 18810-18812 CC denotes or
T9995 18813-18818 JJ denotes empty
T9996 18819-18825 NN denotes vector
T9997 18825-18826 , denotes ,
T9998 18827-18837 VBN denotes stimulated
T9999 18838-18842 IN denotes with
T10000 18843-18846 NNP denotes PMA
T10001 18847-18850 IN denotes for
T10002 18851-18852 CD denotes 5
T10003 18853-18856 NN denotes min
T10004 18856-18857 , denotes ,
T10005 18858-18861 CC denotes and
T10006 18862-18873 RB denotes extensively
T10007 18874-18880 VBD denotes washed
T10008 18881-18883 TO denotes to
T10009 18884-18889 VB denotes avoid
T10010 18890-18893 DT denotes the
T10011 18894-18905 JJ denotes oscillatory
T10012 18906-18913 NN denotes kinetic
T10013 18914-18916 IN denotes of
T10014 18917-18922 JJ denotes NF-κB
T10015 18923-18933 NN denotes activation
T10016 18934-18935 -LRB- denotes (
T10017 18935-18940 CD denotes 17,18
T10018 18940-18941 -RRB- denotes )
T10019 18941-18942 . denotes .
T10020 18943-18945 IN denotes In
T10021 18946-18959 JJ denotes un-stimulated
T10022 18960-18965 NNS denotes cells
T10023 18965-18966 , denotes ,
T10024 18967-18970 DT denotes the
T10025 18971-18974 CD denotes p65
T10026 18975-18978 NNP denotes DNA
T10027 18979-18986 JJ denotes binding
T10028 18987-18988 -LRB- denotes (
T10029 18988-18994 NN denotes Figure
T10030 18995-18997 NN denotes 2A
T10031 18997-18998 -RRB- denotes )
T10032 18999-19002 CC denotes and
T10033 19003-19010 JJ denotes nuclear
T10034 19011-19014 NNS denotes p65
T10035 19015-19016 -LRB- denotes (
T10036 19016-19022 NN denotes Figure
T10037 19023-19025 NN denotes 2B
T10038 19025-19026 , denotes ,
T10039 19027-19034 NN denotes nucleus
T10040 19034-19035 -RRB- denotes )
T10041 19036-19040 VBD denotes were
T10042 19041-19049 RB denotes slightly
T10043 19050-19058 VBN denotes enhanced
T10044 19059-19061 IN denotes by
T10045 19062-19065 NNP denotes Tat
T10046 19065-19066 , denotes ,
T10047 19067-19072 IN denotes while
T10048 19073-19076 DT denotes the
T10049 19077-19082 JJ denotes IκB-α
T10050 19083-19090 NN denotes content
T10051 19091-19094 VBD denotes was
T10052 19095-19098 RB denotes not
T10053 19099-19112 RB denotes significantly
T10054 19113-19121 JJ denotes affected
T10055 19122-19123 -LRB- denotes (
T10056 19123-19129 NN denotes Figure
T10057 19130-19132 NN denotes 2B
T10058 19132-19133 , denotes ,
T10059 19134-19141 NN denotes cytosol
T10060 19141-19142 -RRB- denotes )
T10061 19142-19143 . denotes .
T10062 19144-19153 JJ denotes Transient
T10063 19154-19165 NN denotes stimulation
T10064 19166-19170 IN denotes with
T10065 19171-19174 NNP denotes PMA
T10066 19175-19184 VBD denotes increased
T10067 19185-19188 DT denotes the
T10068 19189-19194 NNP denotes NF-κB
T10069 19195-19198 NNP denotes DNA
T10070 19199-19206 JJ denotes binding
T10071 19207-19215 NN denotes activity
T10072 19216-19219 CC denotes and
T10073 19220-19227 JJ denotes nuclear
T10074 19228-19231 NNS denotes p65
T10075 19232-19234 IN denotes at
T10076 19235-19236 CD denotes 5
T10077 19237-19240 NN denotes min
T10078 19241-19248 VBG denotes peaking
T10079 19249-19251 IN denotes at
T10080 19252-19254 CD denotes 60
T10081 19255-19258 CD denotes 120
T10082 19259-19262 NN denotes min
T10083 19263-19276 RB denotes independently
T10084 19277-19279 IN denotes of
T10085 19280-19283 DT denotes the
T10086 19284-19292 NN denotes presence
T10087 19293-19295 IN denotes of
T10088 19296-19299 NNP denotes Tat
T10089 19300-19301 -LRB- denotes (
T10090 19301-19307 NNP denotes Figure
T10091 19308-19310 NNP denotes 2A
T10092 19311-19314 CC denotes and
T10093 19315-19316 NNP denotes B
T10094 19316-19317 -RRB- denotes )
T10095 19317-19318 : denotes ;
T10096 19319-19326 RB denotes however
T10097 19326-19327 , denotes ,
T10098 19328-19333 IN denotes while
T10099 19334-19337 DT denotes the
T10100 19338-19341 CD denotes p65
T10101 19342-19345 NNP denotes DNA
T10102 19346-19353 JJ denotes binding
T10103 19354-19357 CC denotes and
T10104 19358-19365 JJ denotes nuclear
T10105 19366-19369 NNS denotes p65
T10106 19370-19379 VBD denotes persisted
T10107 19380-19388 VBN denotes elevated
T10108 19389-19391 IN denotes at
T10109 19392-19399 JJ denotes 240-min
T10110 19400-19414 NN denotes post-treatment
T10111 19415-19417 IN denotes in
T10112 19418-19430 JJ denotes Tat-positive
T10113 19431-19436 NNS denotes cells
T10114 19436-19437 , denotes ,
T10115 19438-19442 PRP denotes they
T10116 19443-19450 VBD denotes dropped
T10117 19451-19453 IN denotes in
T10118 19454-19466 JJ denotes Tat-negative
T10119 19467-19472 NNS denotes cells
T10120 19473-19474 -LRB- denotes (
T10121 19474-19480 NN denotes Figure
T10122 19481-19483 CD denotes 2A
T10123 19484-19487 CC denotes and
T10124 19488-19489 NNP denotes B
T10125 19489-19490 -RRB- denotes )
T10126 19490-19491 . denotes .
T10127 19492-19494 IN denotes In
T10128 19495-19503 NN denotes addition
T10129 19503-19504 , denotes ,
T10130 19505-19508 NNP denotes Tat
T10131 19509-19514 VBD denotes bound
T10132 19515-19517 TO denotes to
T10133 19518-19521 DT denotes the
T10134 19522-19527 JJ denotes NF-κB
T10135 19528-19543 NN denotes oligonucleotide
T10136 19544-19546 IN denotes in
T10137 19547-19560 JJ denotes un-stimulated
T10138 19561-19566 NNS denotes cells
T10139 19567-19570 CC denotes and
T10140 19571-19574 PRP$ denotes its
T10141 19575-19582 JJ denotes binding
T10142 19583-19592 VBN denotes increased
T10143 19593-19602 VBG denotes following
T10144 19603-19606 NNP denotes PMA
T10145 19607-19618 NN denotes stimulation
T10146 19619-19620 -LRB- denotes (
T10147 19620-19626 NN denotes Figure
T10148 19627-19629 NN denotes 2A
T10149 19629-19630 -RRB- denotes )
T10150 19630-19631 , denotes ,
T10151 19632-19642 VBG denotes suggesting
T10152 19643-19647 IN denotes that
T10153 19648-19651 DT denotes the
T10154 19652-19657 JJ denotes viral
T10155 19658-19665 NN denotes protein
T10156 19666-19669 VBD denotes was
T10157 19670-19671 DT denotes a
T10158 19672-19681 NN denotes component
T10159 19682-19684 IN denotes of
T10160 19685-19688 DT denotes the
T10161 19689-19694 JJ denotes NF-κB
T10162 19695-19702 JJ denotes complex
T10163 19703-19708 VBN denotes bound
T10164 19709-19711 TO denotes to
T10165 19712-19715 NNP denotes DNA
T10166 19715-19716 . denotes .
T10167 19717-19728 NN denotes Degradation
T10168 19729-19731 IN denotes of
T10169 19732-19737 NNP denotes IκB-α
T10170 19738-19741 VBD denotes was
T10171 19742-19755 RB denotes progressively
T10172 19756-19763 VBN denotes induced
T10173 19764-19766 IN denotes at
T10174 19767-19768 CD denotes 5
T10175 19769-19771 CD denotes 30
T10176 19772-19775 NN denotes min
T10177 19775-19776 , denotes ,
T10178 19777-19785 VBN denotes followed
T10179 19786-19788 IN denotes by
T10180 19789-19791 FW denotes de
T10181 19792-19796 FW denotes novo
T10182 19797-19806 NN denotes synthesis
T10183 19807-19809 IN denotes at
T10184 19810-19812 CD denotes 60
T10185 19813-19816 NN denotes min
T10186 19817-19821 IN denotes with
T10187 19822-19826 JJ denotes full
T10188 19827-19840 NN denotes replenishment
T10189 19841-19843 IN denotes at
T10190 19844-19847 CD denotes 240
T10191 19848-19851 NN denotes min
T10192 19852-19854 IN denotes in
T10193 19855-19859 DT denotes both
T10194 19860-19872 JJ denotes Tat-positive
T10195 19873-19876 CC denotes and
T10196 19877-19885 JJ denotes negative
T10197 19886-19891 NNS denotes cells
T10198 19892-19893 -LRB- denotes (
T10199 19893-19899 NN denotes Figure
T10200 19900-19902 NN denotes 2B
T10201 19902-19903 , denotes ,
T10202 19904-19911 NN denotes cytosol
T10203 19911-19912 -RRB- denotes )
T10204 19912-19913 . denotes .
T10205 19914-19926 RB denotes Consistently
T10206 19926-19927 , denotes ,
T10207 19928-19931 DT denotes the
T10208 19932-19935 NNP denotes IKK
T10209 19936-19946 NN denotes activation
T10210 19947-19954 VBD denotes started
T10211 19955-19957 IN denotes at
T10212 19958-19959 CD denotes 5
T10213 19960-19963 NN denotes min
T10214 19963-19964 , denotes ,
T10215 19965-19968 CC denotes and
T10216 19969-19975 VBD denotes turned
T10217 19976-19979 RP denotes off
T10218 19980-19982 IN denotes at
T10219 19983-19985 CD denotes 30
T10220 19986-19989 NN denotes min
T10221 19990-20003 RB denotes independently
T10222 20004-20006 IN denotes of
T10223 20007-20010 DT denotes the
T10224 20011-20019 NN denotes presence
T10225 20020-20022 IN denotes of
T10226 20023-20026 NNP denotes Tat
T10227 20027-20028 -LRB- denotes (
T10228 20028-20034 NNP denotes Figure
T10229 20035-20037 NNP denotes 2C
T10230 20037-20038 -RRB- denotes )
T10231 20038-20039 . denotes .
T10232 20040-20045 DT denotes These
T10233 20046-20053 NNS denotes results
T10234 20054-20063 VBD denotes indicated
T10235 20064-20068 IN denotes that
T10236 20069-20072 NNP denotes Tat
T10237 20073-20081 VBD denotes enhanced
T10238 20082-20085 DT denotes the
T10239 20086-20091 JJ denotes NF-κB
T10240 20092-20100 NN denotes activity
T10241 20101-20103 IN denotes in
T10242 20104-20117 JJ denotes un-stimulated
T10243 20118-20121 CC denotes and
T10244 20122-20136 JJ denotes PMA-stimulated
T10245 20137-20142 NNS denotes cells
T10246 20143-20150 IN denotes without
T10247 20151-20160 VBG denotes affecting
T10248 20161-20164 DT denotes the
T10249 20165-20168 NNP denotes IKK
T10250 20169-20177 NN denotes activity
T10251 20178-20181 CC denotes and
T10252 20182-20187 JJ denotes IκB-α
T10253 20188-20195 NN denotes content
T10254 20195-20196 . denotes .
T10255 21813-21815 IN denotes As
T10256 21816-21818 PRP denotes we
T10257 21819-21829 RB denotes previously
T10258 21830-21835 VBD denotes found
T10259 21836-21840 IN denotes that
T10260 21841-21844 NNP denotes Tat
T10261 21845-21850 VBZ denotes binds
T10262 21851-21853 TO denotes to
T10263 21854-21857 DT denotes the
T10264 21858-21863 JJ denotes sixth
T10265 21864-21871 NN denotes ankyrin
T10266 21872-21874 IN denotes of
T10267 21875-21880 NNP denotes IκB-α
T10268 21881-21882 -LRB- denotes (
T10269 21882-21887 CD denotes 50,51
T10270 21887-21888 -RRB- denotes )
T10271 21888-21889 , denotes ,
T10272 21890-21892 PRP denotes we
T10273 21893-21899 VBD denotes tested
T10274 21900-21907 IN denotes whether
T10275 21908-21911 NNP denotes Tat
T10276 21912-21924 VBD denotes counteracted
T10277 21925-21928 DT denotes the
T10278 21929-21939 NN denotes generation
T10279 21940-21942 IN denotes of
T10280 21943-21946 DT denotes the
T10281 21947-21952 NNP denotes IκB-α
T10282 21952-21953 NNP denotes /
T10283 21953-21958 NNP denotes NF-κB
T10284 21959-21966 NN denotes complex
T10285 21966-21967 . denotes .
T10286 21968-21970 TO denotes To
T10287 21971-21975 DT denotes this
T10288 21976-21979 NN denotes end
T10289 21979-21980 , denotes ,
T10290 21981-21984 DT denotes the
T10291 21985-21996 NN denotes association
T10292 21997-21999 IN denotes of
T10293 22000-22005 JJ denotes IκB-α
T10294 22006-22010 IN denotes with
T10295 22011-22014 CD denotes p65
T10296 22015-22018 VBD denotes was
T10297 22019-22027 VBN denotes analysed
T10298 22028-22030 IN denotes in
T10299 22031-22035 NN denotes vivo
T10300 22036-22038 IN denotes at
T10301 22039-22040 CD denotes 0
T10302 22041-22044 CC denotes and
T10303 22045-22048 CD denotes 240
T10304 22049-22052 NN denotes min
T10305 22053-22058 IN denotes after
T10306 22059-22070 JJ denotes short-pulse
T10307 22071-22074 NNP denotes PMA
T10308 22074-22075 , denotes ,
T10309 22076-22081 WDT denotes which
T10310 22082-22094 VBD denotes corresponded
T10311 22095-22097 TO denotes to
T10312 22098-22101 DT denotes the
T10313 22102-22106 NN denotes time
T10314 22107-22109 IN denotes of
T10315 22110-22123 JJ denotes un-stimulated
T10316 22124-22133 NN denotes condition
T10317 22134-22137 CC denotes and
T10318 22138-22153 NN denotes post-activation
T10319 22154-22156 IN denotes de
T10320 22157-22161 NN denotes novo
T10321 22162-22171 NN denotes synthesis
T10322 22172-22174 IN denotes of
T10323 22175-22180 NNP denotes IκB-α
T10324 22180-22181 , denotes ,
T10325 22182-22194 RB denotes respectively
T10326 22194-22195 . denotes .
T10327 22196-22217 NNP denotes Coimmunoprecipitation
T10328 22218-22220 IN denotes of
T10329 22221-22226 NNP denotes IκB-α
T10330 22227-22231 IN denotes with
T10331 22232-22235 CD denotes p65
T10332 22236-22239 VBD denotes was
T10333 22240-22248 VBN denotes detected
T10334 22249-22251 IN denotes at
T10335 22252-22253 CD denotes 0
T10336 22253-22254 : denotes -
T10337 22255-22258 CC denotes and
T10338 22259-22266 JJ denotes 240-min
T10339 22267-22281 NN denotes post-treatment
T10340 22282-22284 IN denotes in
T10341 22285-22297 JJ denotes Tat-negative
T10342 22298-22303 NNS denotes cells
T10343 22304-22305 -LRB- denotes (
T10344 22305-22311 NN denotes Figure
T10345 22312-22314 CD denotes 2D
T10346 22314-22315 , denotes ,
T10347 22316-22321 NNS denotes lanes
T10348 22322-22323 CD denotes 1
T10349 22324-22327 CC denotes and
T10350 22328-22329 CD denotes 3
T10351 22329-22330 -RRB- denotes )
T10352 22330-22331 , denotes ,
T10353 22332-22335 CC denotes and
T10354 22336-22339 VBD denotes was
T10355 22340-22346 VBN denotes halved
T10356 22347-22349 IN denotes in
T10357 22350-22362 JJ denotes Tat-positive
T10358 22363-22368 NNS denotes cells
T10359 22368-22369 , denotes ,
T10360 22370-22375 WRB denotes where
T10361 22376-22379 NNP denotes Tat
T10362 22380-22400 VBD denotes coimmunoprecipitated
T10363 22401-22405 IN denotes with
T10364 22406-22411 NNP denotes IκB-α
T10365 22412-22413 -LRB- denotes (
T10366 22413-22419 NNP denotes Figure
T10367 22420-22422 NNP denotes 2D
T10368 22422-22423 , denotes ,
T10369 22424-22429 NNS denotes lanes
T10370 22430-22431 CD denotes 2
T10371 22432-22435 CC denotes and
T10372 22436-22437 CD denotes 4
T10373 22437-22438 -RRB- denotes )
T10374 22438-22439 , denotes ,
T10375 22440-22450 VBG denotes indicating
T10376 22451-22455 IN denotes that
T10377 22456-22459 NNP denotes Tat
T10378 22460-22468 VBD denotes competed
T10379 22469-22472 DT denotes the
T10380 22473-22478 JJ denotes IκB-α
T10381 22479-22486 JJ denotes binding
T10382 22487-22489 TO denotes to
T10383 22490-22493 NNS denotes p65
T10384 22493-22494 . denotes .
T12077 22496-22499 NNP denotes Tat
T12078 22500-22511 VBZ denotes counteracts
T12079 22512-22515 DT denotes the
T12080 22516-22521 JJ denotes IκB-α
T12081 22522-22532 NN denotes inhibition
T12082 22533-22535 IN denotes of
T12083 22536-22539 CD denotes p65
T12084 22540-22542 IN denotes by
T12085 22543-22552 VBG denotes competing
T12086 22553-22556 DT denotes the
T12087 22557-22566 NN denotes repressor
T12088 22567-22574 JJ denotes binding
T12089 22575-22577 PRP denotes We
T12090 22578-22585 RB denotes further
T12091 22586-22598 VBD denotes investigated
T12092 22599-22602 DT denotes the
T12093 22603-22611 JJ denotes physical
T12094 22612-22623 NN denotes interaction
T12095 22624-22626 IN denotes of
T12096 22627-22630 NNP denotes Tat
T12097 22631-22635 IN denotes with
T12098 22636-22641 NNP denotes IκB-α
T12099 22642-22647 VBG denotes using
T12100 22648-22650 IN denotes in
T12101 22651-22656 NN denotes vitro
T12102 22657-22667 VBN denotes translated
T12103 22668-22676 NNS denotes proteins
T12104 22677-22679 IN denotes in
T12105 22680-22701 NN denotes coimmunoprecipitation
T12106 22702-22708 NNS denotes assays
T12107 22708-22709 . denotes .
T12108 22710-22713 IN denotes For
T12109 22714-22721 VBG denotes mapping
T12110 22722-22725 DT denotes the
T12111 22726-22737 NN denotes interaction
T12112 22738-22745 NNS denotes domains
T12113 22745-22746 , denotes ,
T12114 22747-22749 PRP denotes we
T12115 22750-22754 VBD denotes used
T12116 22755-22758 DT denotes the
T12117 22759-22768 JJ denotes following
T12118 22769-22772 NNP denotes Tat
T12119 22773-22780 NNS denotes mutants
T12120 22780-22781 : denotes :
T12121 22782-22785 NNP denotes Tat
T12122 22786-22787 NNP denotes T
T12123 22787-22788 , denotes ,
T12124 22788-22789 NNP denotes N
T12125 22789-22790 -LRB- denotes (
T12126 22790-22795 CD denotes 23,24
T12127 22795-22796 -RRB- denotes )
T12128 22796-22797 DT denotes A
T12129 22797-22798 , denotes ,
T12130 22799-22802 NNP denotes Tat
T12131 22803-22804 NNP denotes C
T12132 22804-22805 -LRB- denotes (
T12133 22805-22813 CD denotes 22,25,27
T12134 22813-22814 -RRB- denotes )
T12135 22814-22815 DT denotes A
T12136 22815-22816 , denotes ,
T12137 22817-22820 NNP denotes Tat
T12138 22821-22822 NNP denotes K
T12139 22822-22823 -LRB- denotes (
T12140 22823-22828 CD denotes 50,51
T12141 22828-22829 -RRB- denotes )
T12142 22829-22830 DT denotes A
T12143 22831-22834 CC denotes and
T12144 22835-22838 NNP denotes Tat
T12145 22839-22840 NNP denotes R
T12146 22840-22841 -LRB- denotes (
T12147 22841-22843 CD denotes 49
T12148 22844-22846 CD denotes 57
T12149 22846-22847 -RRB- denotes )
T12150 22847-22848 DT denotes A
T12151 22849-22850 -LRB- denotes (
T12152 22850-22856 NN denotes Figure
T12153 22857-22859 NN denotes 3A
T12154 22859-22860 -RRB- denotes )
T12155 22860-22861 . denotes .
T12156 22862-22867 JJ denotes IκB-α
T12157 22868-22888 VBN denotes coimmunoprecipitated
T12158 22889-22893 IN denotes with
T12159 22894-22897 DT denotes all
T12160 22898-22901 NNP denotes Tat
T12161 22902-22910 NNS denotes proteins
T12162 22910-22911 , denotes ,
T12163 22912-22918 IN denotes except
T12164 22919-22922 NNP denotes Tat
T12165 22923-22924 NNP denotes R
T12166 22924-22925 -LRB- denotes (
T12167 22925-22927 CD denotes 49
T12168 22928-22930 CD denotes 57
T12169 22930-22931 -RRB- denotes )
T12170 22931-22932 DT denotes A
T12171 22933-22934 -LRB- denotes (
T12172 22934-22940 NN denotes Figure
T12173 22941-22943 NN denotes 3B
T12174 22943-22944 -RRB- denotes )
T12175 22944-22945 . denotes .
T12176 22946-22951 DT denotes These
T12177 22952-22959 NNS denotes results
T12178 22960-22969 VBD denotes indicated
T12179 22970-22974 IN denotes that
T12180 22975-22978 DT denotes the
T12181 22979-22992 JJ denotes arginine-rich
T12182 22993-22999 NN denotes domain
T12183 23000-23002 IN denotes of
T12184 23003-23006 NNP denotes Tat
T12185 23007-23010 VBD denotes was
T12186 23011-23019 VBN denotes involved
T12187 23020-23022 IN denotes in
T12188 23023-23026 DT denotes the
T12189 23027-23034 JJ denotes binding
T12190 23035-23037 TO denotes to
T12191 23038-23043 NNP denotes IκB-α
T12192 23043-23044 , denotes ,
T12193 23045-23050 WDT denotes which
T12194 23051-23054 VBD denotes was
T12195 23055-23065 JJ denotes consistent
T12196 23066-23070 IN denotes with
T12197 23071-23079 JJ denotes previous
T12198 23080-23092 NNS denotes observations
T12199 23093-23094 -LRB- denotes (
T12200 23094-23099 CD denotes 50,51
T12201 23099-23100 -RRB- denotes )
T12202 23100-23101 . denotes .
T12203 23102-23110 RB denotes Moreover
T12204 23110-23111 , denotes ,
T12205 23112-23115 NNP denotes Tat
T12206 23116-23127 VBG denotes associating
T12207 23128-23132 IN denotes with
T12208 23133-23138 JJ denotes IκB-α
T12209 23139-23147 VBN denotes competed
T12210 23148-23151 DT denotes the
T12211 23152-23159 JJ denotes binding
T12212 23160-23162 IN denotes of
T12213 23163-23168 NNP denotes IκB-α
T12214 23169-23171 TO denotes to
T12215 23172-23175 VB denotes p65
T12216 23176-23178 IN denotes in
T12217 23179-23180 DT denotes a
T12218 23181-23195 JJ denotes dose-dependent
T12219 23196-23202 NN denotes manner
T12220 23203-23204 -LRB- denotes (
T12221 23204-23210 NN denotes Figure
T12222 23211-23213 NN denotes 3C
T12223 23213-23214 , denotes ,
T12224 23215-23220 NNS denotes lanes
T12225 23221-23222 CD denotes 3
T12226 23223-23224 LS denotes 5
T12227 23224-23225 -RRB- denotes )
T12228 23225-23226 , denotes ,
T12229 23227-23232 IN denotes while
T12230 23233-23236 NNP denotes Tat
T12231 23237-23238 NNP denotes R
T12232 23238-23239 -LRB- denotes (
T12233 23239-23241 CD denotes 49
T12234 23242-23244 CD denotes 57
T12235 23244-23245 -RRB- denotes )
T12236 23245-23246 DT denotes A
T12237 23246-23247 , denotes ,
T12238 23248-23253 WDT denotes which
T12239 23254-23260 VBD denotes lacked
T12240 23261-23264 DT denotes the
T12241 23265-23272 JJ denotes binding
T12242 23273-23277 NN denotes site
T12243 23278-23281 IN denotes for
T12244 23282-23287 NNP denotes IκB-α
T12245 23287-23288 , denotes ,
T12246 23289-23292 VBD denotes did
T12247 23293-23296 RB denotes not
T12248 23297-23306 JJ denotes associate
T12249 23307-23311 IN denotes with
T12250 23312-23317 NNP denotes IκB-α
T12251 23318-23321 CC denotes and
T12252 23322-23325 VBD denotes did
T12253 23326-23329 RB denotes not
T12254 23330-23337 VB denotes compete
T12255 23338-23341 DT denotes the
T12256 23342-23349 JJ denotes binding
T12257 23350-23352 IN denotes of
T12258 23353-23358 NNP denotes IκB-α
T12259 23359-23361 TO denotes to
T12260 23362-23365 VB denotes p65
T12261 23366-23367 -LRB- denotes (
T12262 23367-23373 NN denotes Figure
T12263 23374-23376 NN denotes 3C
T12264 23376-23377 , denotes ,
T12265 23378-23383 NNS denotes lanes
T12266 23384-23385 CD denotes 6
T12267 23386-23387 CD denotes 8
T12268 23387-23388 -RRB- denotes )
T12269 23388-23389 . denotes .
T12270 25484-25488 JJ denotes Next
T12271 25488-25489 , denotes ,
T12272 25490-25492 PRP denotes we
T12273 25493-25502 VBD denotes evaluated
T12274 25503-25510 IN denotes whether
T12275 25511-25514 NNP denotes Tat
T12276 25515-25527 VBD denotes counteracted
T12277 25528-25531 DT denotes the
T12278 25532-25546 NNP denotes IκB-α-mediated
T12279 25547-25557 NN denotes inhibition
T12280 25558-25560 IN denotes of
T12281 25561-25564 CD denotes p65
T12282 25565-25572 JJ denotes binding
T12283 25573-25575 TO denotes to
T12284 25576-25579 NNP denotes DNA
T12285 25580-25582 IN denotes by
T12286 25583-25593 VBG denotes incubating
T12287 25594-25596 IN denotes in
T12288 25597-25602 NN denotes vitro
T12289 25603-25613 VBN denotes translated
T12290 25614-25617 NNS denotes p65
T12291 25618-25621 CC denotes and
T12292 25622-25627 JJ denotes IκB-α
T12293 25628-25636 NNS denotes proteins
T12294 25637-25641 IN denotes with
T12295 25642-25645 DT denotes the
T12296 25646-25651 NNP denotes NF-κB
T12297 25652-25657 NN denotes probe
T12298 25658-25660 IN denotes in
T12299 25661-25669 NN denotes presence
T12300 25670-25672 CC denotes or
T12301 25673-25680 NN denotes absence
T12302 25681-25683 IN denotes of
T12303 25684-25687 NNP denotes Tat
T12304 25688-25696 VBD denotes followed
T12305 25697-25699 IN denotes by
T12306 25700-25704 NNP denotes EMSA
T12307 25704-25705 . denotes .
T12308 25706-25709 DT denotes The
T12309 25710-25713 CD denotes p65
T12310 25714-25717 NNP denotes DNA
T12311 25718-25725 JJ denotes binding
T12312 25726-25734 NN denotes activity
T12313 25735-25738 VBD denotes was
T12314 25739-25748 VBN denotes inhibited
T12315 25749-25751 IN denotes by
T12316 25752-25757 NNP denotes IκB-α
T12317 25758-25761 CC denotes and
T12318 25762-25770 VBN denotes restored
T12319 25771-25773 IN denotes in
T12320 25774-25775 DT denotes a
T12321 25776-25790 JJ denotes dose-dependent
T12322 25791-25797 NN denotes manner
T12323 25798-25800 IN denotes by
T12324 25801-25810 JJ denotes wild-type
T12325 25811-25814 NNP denotes Tat
T12326 25814-25815 , denotes ,
T12327 25816-25819 CC denotes and
T12328 25820-25823 RB denotes not
T12329 25824-25826 IN denotes by
T12330 25827-25830 NNP denotes Tat
T12331 25831-25832 NNP denotes R
T12332 25832-25833 -LRB- denotes (
T12333 25833-25835 CD denotes 49
T12334 25836-25838 CD denotes 57
T12335 25838-25839 -RRB- denotes )
T12336 25840-25841 -LRB- denotes (
T12337 25841-25847 NNP denotes Figure
T12338 25848-25850 NNP denotes 3D
T12339 25850-25851 -RRB- denotes )
T12340 25851-25852 . denotes .
T12341 25853-25860 RB denotes Further
T12342 25860-25861 , denotes ,
T12343 25862-25864 PRP denotes we
T12344 25865-25873 VBD denotes analysed
T12345 25874-25877 DT denotes the
T12346 25878-25881 NNP denotes Tat
T12347 25882-25888 NN denotes effect
T12348 25889-25891 IN denotes on
T12349 25892-25895 DT denotes the
T12350 25896-25901 JJ denotes IκB-α
T12351 25902-25912 NN denotes repression
T12352 25913-25915 IN denotes of
T12353 25916-25919 CD denotes p65
T12354 25920-25935 JJ denotes transcriptional
T12355 25936-25944 NN denotes activity
T12356 25945-25947 IN denotes by
T12357 25948-25960 VBG denotes transfecting
T12358 25961-25964 CD denotes p50
T12359 25964-25965 FW denotes −
T12360 25965-25966 FW denotes /
T12361 25966-25967 FW denotes −
T12362 25967-25970 FW denotes p65
T12363 25970-25971 FW denotes −
T12364 25971-25972 FW denotes /
T12365 25972-25973 FW denotes −
T12366 25973-25977 FW denotes MEFs
T12367 25978-25982 IN denotes with
T12368 25983-25986 DT denotes the
T12369 25987-25996 JJ denotes NF-κB-Luc
T12370 25997-26005 NN denotes reporter
T12371 26006-26014 RB denotes together
T12372 26015-26019 IN denotes with
T12373 26020-26030 NN denotes expression
T12374 26031-26038 NNS denotes vectors
T12375 26039-26041 IN denotes of
T12376 26042-26045 CD denotes p65
T12377 26046-26049 CC denotes and
T12378 26050-26055 NNP denotes IκB-α
T12379 26055-26056 , denotes ,
T12380 26057-26059 IN denotes in
T12381 26060-26068 NN denotes presence
T12382 26069-26071 CC denotes or
T12383 26072-26079 NN denotes absence
T12384 26080-26082 IN denotes of
T12385 26083-26086 NNP denotes Tat
T12386 26086-26087 . denotes .
T12387 26088-26093 JJ denotes IκB-α
T12388 26094-26103 VBD denotes inhibited
T12389 26104-26107 DT denotes the
T12390 26108-26121 JJ denotes p65-dependent
T12391 26122-26132 NN denotes expression
T12392 26133-26135 IN denotes of
T12393 26136-26139 DT denotes the
T12394 26140-26150 NN denotes luciferase
T12395 26151-26155 NN denotes gene
T12396 26155-26156 , denotes ,
T12397 26157-26162 WDT denotes which
T12398 26163-26166 VBD denotes was
T12399 26167-26175 VBN denotes restored
T12400 26176-26178 IN denotes in
T12401 26179-26180 DT denotes a
T12402 26181-26195 JJ denotes dose-dependent
T12403 26196-26202 NN denotes manner
T12404 26203-26205 IN denotes by
T12405 26206-26215 JJ denotes wild-type
T12406 26216-26219 NNP denotes Tat
T12407 26219-26220 , denotes ,
T12408 26221-26224 CC denotes and
T12409 26225-26228 RB denotes not
T12410 26229-26231 IN denotes by
T12411 26232-26235 NNP denotes Tat
T12412 26236-26237 NNP denotes R
T12413 26237-26238 -LRB- denotes (
T12414 26238-26240 CD denotes 49
T12415 26241-26243 CD denotes 57
T12416 26243-26244 -RRB- denotes )
T12417 26244-26245 DT denotes A
T12418 26246-26247 -LRB- denotes (
T12419 26247-26253 NN denotes Figure
T12420 26254-26256 CD denotes 3E
T12421 26256-26257 -RRB- denotes )
T12422 26257-26258 . denotes .
T12423 26259-26269 RB denotes Altogether
T12424 26270-26275 DT denotes these
T12425 26276-26283 NNS denotes results
T12426 26284-26293 VBD denotes indicated
T12427 26294-26298 IN denotes that
T12428 26299-26302 NNP denotes Tat
T12429 26303-26314 VBZ denotes counteracts
T12430 26315-26318 DT denotes the
T12431 26319-26324 JJ denotes IκB-α
T12432 26325-26335 NN denotes repression
T12433 26336-26338 IN denotes of
T12434 26339-26342 DT denotes the
T12435 26343-26346 CD denotes p65
T12436 26347-26358 JJ denotes DNA-binding
T12437 26359-26362 CC denotes and
T12438 26363-26378 JJ denotes transcriptional
T12439 26379-26387 NN denotes activity
T12440 26388-26390 IN denotes by
T12441 26391-26402 VBG denotes associating
T12442 26403-26407 IN denotes with
T12443 26408-26413 NNP denotes IκB-α
T12444 26414-26417 CC denotes and
T12445 26418-26427 VBG denotes competing
T12446 26428-26431 DT denotes the
T12447 26432-26441 NN denotes repressor
T12448 26442-26449 JJ denotes binding
T12449 26450-26452 TO denotes to
T12450 26453-26456 NNS denotes p65
T12451 26456-26457 . denotes .
T13857 26459-26462 NNP denotes Tat
T13858 26463-26472 VBZ denotes increases
T13859 26473-26476 DT denotes the
T13860 26477-26480 CD denotes p65
T13861 26481-26489 NN denotes affinity
T13862 26490-26497 JJ denotes binding
T13863 26498-26500 TO denotes to
T13864 26501-26504 NNP denotes DNA
T13865 26505-26512 IN denotes through
T13866 26513-26524 NN denotes association
T13867 26525-26529 IN denotes with
T13868 26530-26533 CD denotes p65
T13869 26534-26536 PRP denotes We
T13870 26537-26543 VBD denotes tested
T13871 26544-26551 IN denotes whether
T13872 26552-26555 NNP denotes Tat
T13873 26556-26566 RB denotes physically
T13874 26567-26577 VBD denotes interacted
T13875 26578-26582 IN denotes with
T13876 26583-26586 NNS denotes p65
T13877 26586-26587 . denotes .
T13878 26588-26592 NNP denotes HeLa
T13879 26593-26598 NNS denotes cells
T13880 26599-26603 VBD denotes were
T13881 26604-26615 VBN denotes transfected
T13882 26616-26620 IN denotes with
T13883 26621-26624 DT denotes the
T13884 26625-26635 NN denotes expression
T13885 26636-26643 NNS denotes vectors
T13886 26644-26646 IN denotes of
T13887 26647-26653 NNP denotes HA-p65
T13888 26654-26657 CC denotes and
T13889 26658-26666 NNP denotes FLAG-Tat
T13890 26666-26667 , denotes ,
T13891 26668-26671 CC denotes and
T13892 26672-26674 CD denotes 24
T13893 26675-26676 NN denotes h
T13894 26677-26682 RB denotes later
T13895 26683-26686 NNP denotes Tat
T13896 26687-26690 VBD denotes was
T13897 26691-26709 VBN denotes immunoprecipitated
T13898 26710-26714 IN denotes from
T13899 26715-26719 NN denotes cell
T13900 26720-26728 NNS denotes extracts
T13901 26728-26729 . denotes .
T13902 26730-26733 DT denotes The
T13903 26734-26737 CD denotes p65
T13904 26738-26745 NN denotes protein
T13905 26746-26749 VBD denotes was
T13906 26750-26770 VBN denotes coimmunoprecipitated
T13907 26771-26775 IN denotes with
T13908 26776-26785 JJ denotes wild-type
T13909 26786-26789 NNP denotes Tat
T13910 26790-26792 CC denotes or
T13911 26793-26796 DT denotes the
T13912 26797-26804 NNS denotes mutants
T13913 26805-26808 NNP denotes Tat
T13914 26809-26810 NNP denotes T
T13915 26810-26811 , denotes ,
T13916 26811-26812 NNP denotes N
T13917 26812-26813 -LRB- denotes (
T13918 26813-26818 CD denotes 23,24
T13919 26818-26819 -RRB- denotes )
T13920 26819-26820 DT denotes A
T13921 26820-26821 , denotes ,
T13922 26822-26825 NNP denotes Tat
T13923 26826-26827 NNP denotes K
T13924 26827-26828 -LRB- denotes (
T13925 26828-26833 CD denotes 50,51
T13926 26833-26834 -RRB- denotes )
T13927 26834-26835 DT denotes A
T13928 26836-26839 CC denotes and
T13929 26840-26843 NNP denotes Tat
T13930 26844-26845 NNP denotes R
T13942 26845-26846 -LRB- denotes (
T13943 26846-26848 CD denotes 49
T13944 26849-26851 CD denotes 57
T13945 26851-26852 -RRB- denotes )
T13946 26852-26853 DT denotes A
T13947 26854-26856 IN denotes at
T13948 26857-26864 JJ denotes similar
T13949 26865-26871 NNS denotes levels
T13950 26871-26872 , denotes ,
T13951 26873-26878 IN denotes while
T13952 26879-26880 DT denotes a
T13953 26881-26892 JJ denotes significant
T13954 26893-26901 NN denotes decrease
T13955 26902-26904 IN denotes in
T13956 26905-26926 NN denotes coimmunoprecipitation
T13957 26927-26930 VBD denotes was
T13958 26931-26939 VBN denotes observed
T13959 26940-26943 IN denotes for
T13960 26944-26947 NNP denotes Tat
T13961 26948-26949 NNP denotes C
T13962 26949-26950 -LRB- denotes (
T13963 26950-26958 CD denotes 22,25,27
T13964 26958-26959 -RRB- denotes )
T13965 26959-26960 DT denotes A
T13966 26961-26962 -LRB- denotes (
T13967 26962-26968 NN denotes Figure
T13968 26969-26971 NN denotes 4A
T13969 26971-26972 -RRB- denotes )
T13970 26972-26973 . denotes .
T13971 26974-26986 RB denotes Consistently
T13972 26986-26987 , denotes ,
T13973 26988-26996 NNP denotes GST-pull
T13974 26997-27001 IN denotes down
T13975 27002-27004 IN denotes of
T13976 27005-27007 IN denotes in
T13977 27008-27013 NN denotes vitro
T13978 27014-27024 VBN denotes translated
T13979 27025-27033 NNS denotes proteins
T13980 27034-27040 VBD denotes showed
T13981 27041-27044 DT denotes the
T13982 27045-27051 JJ denotes direct
T13983 27052-27059 JJ denotes binding
T13984 27060-27062 IN denotes of
T13985 27063-27066 CD denotes p65
T13986 27067-27069 TO denotes to
T13987 27070-27079 JJ denotes wild-type
T13988 27080-27083 NNP denotes Tat
T13989 27083-27084 , denotes ,
T13990 27085-27087 CC denotes or
T13991 27088-27091 DT denotes the
T13992 27092-27099 NNS denotes mutants
T13993 27100-27103 NNP denotes Tat
T13994 27104-27105 NNP denotes T
T13995 27105-27106 , denotes ,
T13996 27106-27107 NNP denotes N
T13997 27107-27108 -LRB- denotes (
T13998 27108-27113 CD denotes 23,24
T13999 27113-27114 -RRB- denotes )
T14000 27114-27115 DT denotes A
T14001 27115-27116 , denotes ,
T14002 27117-27120 NNP denotes Tat
T14003 27121-27122 NNP denotes K
T14004 27122-27123 -LRB- denotes (
T14005 27123-27128 CD denotes 50,51
T14006 27128-27129 -RRB- denotes )
T14007 27129-27130 DT denotes A
T14008 27131-27134 CC denotes and
T14009 27135-27138 NNP denotes Tat
T14010 27139-27140 NNP denotes R
T14011 27140-27141 -LRB- denotes (
T14012 27141-27143 CD denotes 49
T14013 27144-27146 CD denotes 57
T14014 27146-27147 -RRB- denotes )
T14015 27147-27148 DT denotes A
T14016 27148-27149 , denotes ,
T14017 27150-27153 CC denotes and
T14018 27154-27158 NN denotes lack
T14019 27159-27161 IN denotes of
T14020 27162-27169 JJ denotes binding
T14021 27170-27172 TO denotes to
T14022 27173-27176 NNP denotes Tat
T14023 27177-27178 NNP denotes C
T14024 27178-27179 -LRB- denotes (
T14025 27179-27187 CD denotes 22,25,27
T14026 27187-27188 -RRB- denotes )
T14027 27188-27189 DT denotes A
T14028 27190-27191 -LRB- denotes (
T14029 27191-27197 NN denotes Figure
T14030 27198-27200 NN denotes 4B
T14031 27200-27201 -RRB- denotes )
T14032 27201-27202 . denotes .
T14033 27203-27208 DT denotes These
T14034 27209-27216 NNS denotes results
T14035 27217-27226 VBD denotes indicated
T14036 27227-27231 IN denotes that
T14037 27232-27235 NNP denotes Tat
T14038 27236-27246 VBN denotes associated
T14039 27247-27251 IN denotes with
T14040 27252-27255 CD denotes p65
T14041 27256-27263 IN denotes through
T14042 27264-27267 DT denotes the
T14043 27268-27281 JJ denotes cysteine-rich
T14044 27282-27288 NN denotes domain
T14045 27289-27292 CC denotes and
T14046 27293-27302 NN denotes ruled-out
T14047 27303-27306 DT denotes the
T14048 27307-27318 NN denotes requirement
T14049 27319-27321 IN denotes of
T14050 27322-27330 VBG denotes bridging
T14051 27331-27339 NNS denotes proteins
T14052 27340-27342 TO denotes to
T14053 27343-27350 VB denotes mediate
T14054 27351-27355 JJ denotes such
T14055 27356-27367 NN denotes interaction
T14056 27367-27368 . denotes .
T14057 29093-29095 TO denotes To
T14058 29096-29104 VB denotes identify
T14059 29105-29108 DT denotes the
T14060 29109-29112 NNS denotes p65
T14061 29113-29119 NN denotes domain
T14062 29120-29128 VBN denotes required
T14063 29129-29132 IN denotes for
T14064 29133-29140 JJ denotes binding
T14065 29141-29143 TO denotes to
T14066 29144-29147 NNP denotes Tat
T14067 29147-29148 , denotes ,
T14068 29149-29153 NNP denotes HeLa
T14069 29154-29159 NNS denotes cells
T14070 29160-29164 VBD denotes were
T14071 29165-29176 VBN denotes transfected
T14072 29177-29181 IN denotes with
T14073 29182-29190 JJ denotes FLAG-Tat
T14074 29191-29199 RB denotes together
T14075 29200-29204 IN denotes with
T14076 29205-29211 JJ denotes HA-p65
T14077 29212-29219 NNS denotes mutants
T14078 29219-29220 , denotes ,
T14079 29221-29226 WDT denotes which
T14080 29227-29231 VBD denotes were
T14081 29232-29239 VBN denotes deleted
T14082 29240-29242 IN denotes of
T14083 29243-29246 DT denotes the
T14084 29247-29262 NN denotes transactivation
T14085 29263-29269 NN denotes domain
T14086 29270-29271 NNP denotes [
T14087 29271-29276 NNP denotes p65ΔC
T14088 29277-29278 -LRB- denotes (
T14089 29278-29279 CD denotes 1
T14090 29280-29283 CD denotes 318
T14091 29283-29284 -RRB- denotes )
T14092 29284-29285 NNP denotes ]
T14093 29285-29286 , denotes ,
T14094 29287-29289 CC denotes or
T14095 29290-29293 DT denotes the
T14096 29294-29297 NNP denotes RHD
T14097 29298-29299 NNP denotes [
T14098 29299-29304 NNP denotes p65ΔN
T14099 29305-29306 -LRB- denotes (
T14100 29306-29309 CD denotes 122
T14101 29310-29313 CD denotes 551
T14102 29313-29314 -RRB- denotes )
T14103 29314-29315 NNP denotes ]
T14104 29316-29317 -LRB- denotes (
T14105 29317-29323 NNP denotes Figure
T14106 29324-29326 NNP denotes 4C
T14107 29326-29327 -RRB- denotes )
T14108 29327-29328 . denotes .
T14109 29329-29332 NNP denotes Tat
T14110 29333-29353 VBD denotes coimmunoprecipitated
T14111 29354-29358 IN denotes with
T14112 29359-29364 NNP denotes p65ΔC
T14113 29365-29366 -LRB- denotes (
T14114 29366-29367 CD denotes 1
T14115 29368-29371 CD denotes 318
T14116 29371-29372 -RRB- denotes )
T14117 29372-29373 , denotes ,
T14118 29374-29377 CC denotes and
T14119 29378-29381 RB denotes not
T14120 29382-29386 IN denotes with
T14121 29387-29392 NNP denotes p65ΔN
T14122 29393-29394 -LRB- denotes (
T14123 29394-29397 CD denotes 122
T14124 29398-29401 CD denotes 551
T14125 29401-29402 -RRB- denotes )
T14126 29403-29404 -LRB- denotes (
T14127 29404-29410 NN denotes Figure
T14128 29411-29413 CD denotes 4D
T14129 29413-29414 -RRB- denotes )
T14130 29414-29415 , denotes ,
T14131 29416-29426 VBG denotes indicating
T14132 29427-29431 IN denotes that
T14133 29432-29435 DT denotes the
T14134 29436-29439 NNP denotes RHD
T14135 29440-29442 IN denotes of
T14136 29443-29446 CD denotes p65
T14137 29447-29450 VBD denotes was
T14138 29451-29459 VBN denotes involved
T14139 29460-29462 IN denotes in
T14140 29463-29466 DT denotes the
T14141 29467-29475 JJ denotes physical
T14142 29476-29487 NN denotes interaction
T14143 29488-29492 IN denotes with
T14144 29493-29496 NNP denotes Tat
T14145 29496-29497 . denotes .
T14146 29498-29500 TO denotes To
T14147 29501-29508 VB denotes address
T14148 29509-29512 DT denotes the
T14149 29513-29519 NN denotes effect
T14150 29520-29522 IN denotes of
T14151 29523-29526 NNP denotes Tat
T14152 29527-29529 IN denotes on
T14153 29530-29533 DT denotes the
T14154 29534-29537 CD denotes p65
T14155 29538-29549 JJ denotes DNA-binding
T14156 29550-29558 NN denotes affinity
T14157 29558-29559 , denotes ,
T14158 29560-29568 VBN denotes purified
T14159 29569-29580 JJ denotes recombinant
T14160 29581-29584 NNS denotes p65
T14161 29585-29592 NN denotes protein
T14162 29593-29596 VBD denotes was
T14163 29597-29606 VBN denotes incubated
T14164 29607-29611 IN denotes with
T14165 29612-29629 JJ denotes 32P-labeled-NF-κB
T14166 29630-29645 JJ denotes double-stranded
T14167 29646-29661 NN denotes oligonucleotide
T14168 29662-29664 IN denotes in
T14169 29665-29673 NN denotes presence
T14170 29674-29676 CC denotes or
T14171 29677-29684 NN denotes absence
T14172 29685-29687 IN denotes of
T14173 29688-29697 JJ denotes wild-type
T14174 29698-29701 NNP denotes Tat
T14175 29702-29704 CC denotes or
T14176 29705-29708 NNP denotes Tat
T14177 29709-29710 NNP denotes C
T14178 29710-29711 -LRB- denotes (
T14179 29711-29719 CD denotes 22,25,27
T14180 29719-29720 -RRB- denotes )
T14181 29720-29721 DT denotes A
T14182 29721-29722 , denotes ,
T14183 29723-29726 CC denotes and
T14184 29727-29730 CD denotes p65
T14185 29731-29742 JJ denotes DNA-binding
T14186 29743-29746 VBD denotes was
T14187 29747-29755 VBN denotes analysed
T14188 29756-29758 IN denotes by
T14189 29759-29763 NNP denotes EMSA
T14190 29763-29764 . denotes .
T14191 29765-29772 IN denotes Whereas
T14192 29773-29782 JJ denotes wild-type
T14193 29783-29786 NNP denotes Tat
T14194 29787-29800 RB denotes significantly
T14195 29801-29810 VBD denotes increased
T14196 29811-29814 DT denotes the
T14197 29815-29822 JJ denotes binding
T14198 29823-29825 IN denotes of
T14199 29826-29829 CD denotes p65
T14200 29830-29832 TO denotes to
T14201 29833-29836 NNP denotes DNA
T14202 29836-29837 , denotes ,
T14203 29838-29841 DT denotes the
T14204 29842-29848 JJ denotes mutant
T14205 29849-29852 NNP denotes Tat
T14206 29853-29854 NNP denotes C
T14207 29854-29855 -LRB- denotes (
T14208 29855-29863 CD denotes 22,25,27
T14209 29863-29864 -RRB- denotes )
T14210 29864-29865 DT denotes A
T14211 29865-29866 , denotes ,
T14212 29867-29874 VBG denotes lacking
T14213 29875-29878 DT denotes the
T14214 29879-29886 JJ denotes binding
T14215 29887-29891 NN denotes site
T14216 29892-29895 IN denotes for
T14217 29896-29899 NNS denotes p65
T14218 29899-29900 , denotes ,
T14219 29901-29904 VBD denotes was
T14220 29905-29916 JJ denotes ineffective
T14221 29917-29918 -LRB- denotes (
T14222 29918-29924 NN denotes Figure
T14223 29925-29927 CD denotes 4E
T14224 29927-29928 -RRB- denotes )
T14225 29928-29929 . denotes .
T14226 29930-29933 DT denotes The
T14227 29934-29937 CD denotes p65
T14228 29938-29945 JJ denotes binding
T14229 29946-29948 TO denotes to
T14230 29949-29952 NNP denotes DNA
T14231 29953-29956 VBD denotes was
T14232 29957-29966 VBN denotes evaluated
T14233 29967-29969 IN denotes by
T14234 29970-29981 NN denotes competition
T14235 29982-29986 IN denotes with
T14236 29987-29997 VBG denotes increasing
T14237 29998-30005 NNS denotes amounts
T14238 30006-30008 IN denotes of
T14239 30009-30013 JJ denotes cold
T14240 30014-30024 NN denotes competitor
T14241 30025-30030 NN denotes NF-κB
T14242 30031-30046 NN denotes oligonucleotide
T14243 30046-30047 , denotes ,
T14244 30048-30053 WDT denotes which
T14245 30054-30060 VBD denotes showed
T14246 30061-30065 IN denotes that
T14247 30066-30069 NNP denotes Tat
T14248 30070-30083 RB denotes significantly
T14249 30084-30092 VBD denotes enhanced
T14250 30093-30096 DT denotes the
T14251 30097-30100 CD denotes p65
T14252 30101-30109 NN denotes affinity
T14253 30110-30117 JJ denotes binding
T14254 30118-30120 TO denotes to
T14255 30121-30124 NNP denotes DNA
T14256 30125-30126 -LRB- denotes (
T14257 30126-30132 NNP denotes Figure
T14258 30133-30135 NNP denotes 4E
T14259 30136-30139 CC denotes and
T14260 30140-30141 NN denotes F
T14261 30141-30142 -RRB- denotes )
T14262 30142-30143 . denotes .
T15998 30145-30148 NNP denotes Tat
T15999 30149-30158 VBZ denotes activates
T16000 30159-30162 DT denotes the
T16001 30163-30176 JJ denotes p65-dependent
T16002 30177-30187 NN denotes expression
T16003 30188-30190 IN denotes of
T16004 30191-30207 JJ denotes NF-κB-responsive
T16005 30208-30213 NNS denotes genes
T16006 30213-30214 , denotes ,
T16007 30215-30223 VBZ denotes occupies
T16008 30224-30227 DT denotes the
T16009 30228-30233 JJ denotes NF-κB
T16010 30234-30243 NNS denotes enhancers
T16011 30244-30247 CC denotes and
T16012 30248-30256 VBZ denotes promotes
T16013 30257-30260 DT denotes the
T16014 30261-30264 CD denotes p65
T16015 30265-30276 NN denotes recruitment
T16016 30277-30281 IN denotes with
T16017 30282-30287 JJ denotes IκB-α
T16018 30288-30300 NN denotes displacement
T16019 30301-30303 PRP denotes We
T16020 30304-30312 VBD denotes analysed
T16021 30313-30316 DT denotes the
T16022 30317-30323 NN denotes action
T16023 30324-30326 IN denotes of
T16024 30327-30330 NNP denotes Tat
T16025 30331-30333 IN denotes on
T16026 30334-30337 DT denotes the
T16027 30338-30348 NN denotes expression
T16028 30349-30351 IN denotes of
T16029 30352-30368 JJ denotes NF-κB-responsive
T16030 30369-30374 NNS denotes genes
T16031 30375-30377 IN denotes in
T16032 30378-30382 NN denotes vivo
T16033 30382-30383 . denotes .
T16034 30384-30386 TO denotes To
T16035 30387-30391 DT denotes this
T16036 30392-30395 NN denotes end
T16037 30395-30396 , denotes ,
T16038 30397-30401 NNP denotes HeLa
T16039 30402-30407 NNS denotes cells
T16040 30408-30412 VBD denotes were
T16041 30413-30424 VBN denotes transfected
T16042 30425-30429 IN denotes with
T16043 30430-30438 NNP denotes FLAG-Tat
T16044 30438-30439 , denotes ,
T16045 30440-30448 NNP denotes FLAG-Tat
T16046 30449-30450 NNP denotes C
T16047 30450-30451 -LRB- denotes (
T16048 30451-30459 CD denotes 22,25,27
T16049 30459-30460 -RRB- denotes )
T16050 30460-30461 DT denotes A
T16051 30462-30464 CC denotes or
T16052 30465-30473 JJ denotes FLAG-Tat
T16053 30474-30475 NN denotes R
T16054 30475-30476 -LRB- denotes (
T16055 30476-30478 CD denotes 49
T16056 30479-30481 CD denotes 57
T16057 30481-30482 -RRB- denotes )
T16058 30482-30483 DT denotes A
T16059 30483-30484 , denotes ,
T16060 30485-30488 CC denotes and
T16061 30489-30491 CD denotes 48
T16062 30492-30493 NN denotes h
T16063 30494-30499 RB denotes later
T16064 30500-30503 DT denotes the
T16065 30504-30514 NN denotes expression
T16066 30515-30517 IN denotes of
T16067 30518-30519 DT denotes a
T16068 30520-30526 NN denotes number
T16069 30527-30529 IN denotes of
T16070 30530-30545 JJ denotes NF-κB-dependent
T16071 30546-30551 NNS denotes genes
T16072 30552-30555 VBD denotes was
T16073 30556-30564 VBN denotes analysed
T16074 30565-30567 IN denotes by
T16075 30568-30577 JJ denotes real-time
T16076 30578-30581 NNP denotes PCR
T16077 30581-30582 . denotes .
T16078 30583-30586 NNP denotes Tat
T16079 30587-30600 RB denotes significantly
T16080 30601-30610 VBD denotes increased
T16081 30611-30614 DT denotes the
T16082 30615-30625 NN denotes expression
T16083 30626-30628 IN denotes of
T16084 30629-30635 NNP denotes MIP-1α
T16085 30635-30636 , denotes ,
T16086 30637-30641 NNP denotes CSF3
T16087 30641-30642 , denotes ,
T16088 30643-30646 NNP denotes LTA
T16089 30646-30647 , denotes ,
T16090 30648-30654 NNP denotes NFKBIA
T16091 30655-30658 CC denotes and
T16092 30659-30663 NNP denotes TLR2
T16093 30663-30664 , denotes ,
T16094 30665-30670 IN denotes while
T16095 30671-30674 DT denotes the
T16096 30675-30682 NNS denotes mutants
T16097 30683-30686 NNP denotes Tat
T16098 30687-30688 NNP denotes C
T16099 30688-30689 -LRB- denotes (
T16100 30689-30697 CD denotes 22,25,27
T16101 30697-30698 -RRB- denotes )
T16102 30698-30699 DT denotes A
T16103 30700-30703 CC denotes and
T16104 30704-30707 NNP denotes Tat
T16105 30708-30709 NNP denotes R
T16106 30709-30710 -LRB- denotes (
T16107 30710-30712 CD denotes 49
T16108 30713-30715 CD denotes 57
T16109 30715-30716 -RRB- denotes )
T16110 30716-30717 DT denotes A
T16111 30718-30722 VBD denotes were
T16112 30723-30734 JJ denotes ineffective
T16113 30735-30736 -LRB- denotes (
T16114 30736-30742 NN denotes Figure
T16115 30743-30745 CD denotes 5A
T16116 30746-30747 NNP denotes E
T16117 30747-30748 -RRB- denotes )
T16118 30748-30749 . denotes .
T16119 30750-30753 DT denotes The
T16120 30754-30767 JJ denotes Tat-dependent
T16121 30768-30783 NN denotes transactivation
T16122 30784-30786 IN denotes of
T16123 30787-30790 DT denotes the
T16124 30791-30806 JJ denotes NF-κB-dependent
T16125 30807-30812 NNS denotes genes
T16126 30813-30816 VBD denotes was
T16127 30817-30826 VBN denotes abolished
T16128 30827-30831 WRB denotes when
T16129 30832-30837 NNS denotes cells
T16130 30838-30842 VBD denotes were
T16131 30843-30854 VBN denotes transfected
T16132 30855-30859 IN denotes with
T16133 30860-30865 NNP denotes siRNA
T16134 30866-30869 CD denotes p65
T16135 30869-30870 , denotes ,
T16136 30871-30881 VBG denotes indicating
T16137 30882-30886 IN denotes that
T16138 30887-30890 DT denotes the
T16139 30891-30894 NNP denotes Tat
T16140 30895-30910 JJ denotes transcriptional
T16141 30911-30921 NN denotes activation
T16142 30922-30925 VBD denotes was
T16143 30926-30934 VBN denotes mediated
T16144 30935-30937 IN denotes by
T16145 30938-30941 NNS denotes p65
T16146 30942-30943 -LRB- denotes (
T16147 30943-30949 NN denotes Figure
T16148 30950-30952 CD denotes 5A
T16149 30953-30954 NNP denotes E
T16150 30954-30955 -RRB- denotes )
T16151 30955-30956 . denotes .
T16152 30957-30968 RB denotes Differently
T16153 30968-30969 , denotes ,
T16154 30970-30973 DT denotes the
T16155 30974-30984 NN denotes expression
T16156 30985-30987 IN denotes of
T16157 30988-30991 DT denotes the
T16158 30992-31009 JJ denotes NF-κB-independent
T16159 31010-31015 NNS denotes genes
T16160 31016-31021 NNP denotes GAPDH
T16161 31022-31025 CC denotes and
T16162 31026-31030 NNP denotes ACTB
T16163 31031-31034 VBD denotes was
T16164 31035-31045 JJ denotes unaffected
T16165 31046-31048 IN denotes by
T16166 31049-31058 JJ denotes wild-type
T16167 31059-31062 CC denotes and
T16168 31063-31066 NNP denotes Tat
T16169 31067-31074 NNS denotes mutants
T16170 31075-31076 -LRB- denotes (
T16171 31076-31082 NN denotes Figure
T16172 31083-31085 CD denotes 5F
T16173 31086-31089 CC denotes and
T16174 31090-31091 NNP denotes G
T16175 31091-31092 -RRB- denotes )
T16176 31092-31093 . denotes .
T16177 31094-31099 DT denotes These
T16178 31100-31107 NNS denotes results
T16179 31108-31112 VBD denotes were
T16180 31113-31123 JJ denotes consistent
T16181 31124-31128 IN denotes with
T16182 31129-31132 DT denotes the
T16183 31133-31144 NN denotes requirement
T16184 31145-31147 IN denotes of
T16185 31148-31152 DT denotes both
T16186 31153-31156 DT denotes the
T16187 31157-31170 NN denotes cysteine-rich
T16188 31171-31174 CC denotes and
T16189 31175-31188 JJ denotes arginine-rich
T16190 31189-31196 NNS denotes domains
T16191 31197-31199 IN denotes of
T16192 31200-31203 NNP denotes Tat
T16193 31204-31206 TO denotes to
T16194 31207-31214 VB denotes enhance
T16195 31215-31218 DT denotes the
T16196 31219-31224 NN denotes NF-κB
T16197 31225-31233 NN denotes activity
T16198 31233-31234 , denotes ,
T16199 31235-31245 VBG denotes suggesting
T16200 31246-31250 IN denotes that
T16201 31251-31254 DT denotes the
T16202 31255-31268 NN denotes up-regulation
T16203 31269-31271 IN denotes of
T16204 31272-31288 JJ denotes NF-κB-responsive
T16205 31289-31294 NNS denotes genes
T16206 31295-31297 IN denotes by
T16207 31298-31301 NNP denotes Tat
T16208 31302-31307 MD denotes might
T16209 31308-31313 VB denotes occur
T16210 31314-31321 IN denotes through
T16211 31322-31330 JJ denotes physical
T16212 31331-31342 NN denotes interaction
T16213 31343-31345 IN denotes of
T16214 31346-31349 DT denotes the
T16215 31350-31355 JJ denotes viral
T16216 31356-31363 NN denotes protein
T16217 31364-31368 IN denotes with
T16218 31369-31372 CD denotes p65
T16219 31373-31376 CC denotes and
T16220 31377-31382 NNP denotes IκB-α
T16221 31382-31383 . denotes .
T16222 32978-32984 NN denotes MIP-1α
T16223 32984-32985 , denotes ,
T16224 32986-32991 WDT denotes which
T16225 32992-32995 VBD denotes was
T16226 32996-32999 DT denotes the
T16227 33000-33006 RB denotes mostly
T16228 33007-33016 VBN denotes activated
T16229 33017-33021 NN denotes gene
T16230 33022-33024 IN denotes by
T16231 33025-33028 NNP denotes Tat
T16232 33028-33029 , denotes ,
T16233 33030-33037 VBZ denotes encodes
T16234 33038-33041 IN denotes for
T16235 33042-33043 DT denotes a
T16236 33044-33053 NN denotes chemokine
T16237 33054-33058 WDT denotes that
T16238 33059-33067 VBZ denotes promotes
T16239 33068-33071 DT denotes the
T16240 33072-33083 NN denotes recruitment
T16241 33084-33086 IN denotes of
T16242 33087-33103 JJ denotes pro-inflammatory
T16243 33104-33109 NNS denotes cells
T16244 33110-33111 -LRB- denotes (
T16245 33111-33113 CD denotes 56
T16246 33113-33114 -RRB- denotes )
T16247 33114-33115 . denotes .
T16248 33116-33128 RB denotes Consistently
T16249 33129-33133 IN denotes with
T16250 33134-33137 PRP$ denotes our
T16251 33138-33146 NNS denotes findings
T16252 33146-33147 , denotes ,
T16253 33148-33154 JJ denotes MIP-1α
T16254 33155-33165 NN denotes expression
T16255 33166-33169 VBD denotes was
T16256 33170-33179 VBN denotes increased
T16257 33180-33182 IN denotes in
T16258 33183-33188 JJ denotes glial
T16259 33189-33194 NNS denotes cells
T16260 33195-33198 CC denotes and
T16261 33199-33204 JJ denotes lymph
T16262 33205-33210 NNS denotes nodes
T16263 33211-33213 IN denotes of
T16264 33214-33218 NNP denotes AIDS
T16265 33219-33227 NNS denotes patients
T16266 33228-33229 -LRB- denotes (
T16267 33229-33234 CD denotes 57,58
T16268 33234-33235 -RRB- denotes )
T16269 33235-33236 : denotes ;
T16270 33237-33245 RB denotes moreover
T16271 33245-33246 , denotes ,
T16272 33247-33253 JJ denotes MIP-1α
T16273 33254-33264 NN denotes production
T16274 33265-33268 VBD denotes was
T16275 33269-33276 VBN denotes induced
T16276 33277-33279 IN denotes by
T16277 33280-33285 NNP denotes HIV-1
T16278 33286-33295 NN denotes infection
T16279 33296-33297 -LRB- denotes (
T16280 33297-33302 CD denotes 59,60
T16281 33302-33303 -RRB- denotes )
T16282 33304-33307 CC denotes and
T16283 33308-33311 NNP denotes Tat
T16284 33312-33319 NN denotes protein
T16285 33320-33321 -LRB- denotes (
T16286 33321-33329 CD denotes 57,61,62
T16287 33329-33330 -RRB- denotes )
T16288 33330-33331 . denotes .
T16289 33332-33335 DT denotes The
T16290 33336-33351 JJ denotes transcriptional
T16291 33352-33362 NN denotes regulation
T16292 33363-33365 IN denotes of
T16293 33366-33372 NN denotes MIP-1α
T16294 33373-33376 VBZ denotes has
T16295 33377-33381 VBN denotes been
T16296 33382-33388 RB denotes poorly
T16297 33389-33402 VBN denotes characterized
T16298 33402-33403 . denotes .
T16299 33404-33416 JJ denotes Jaspar-based
T16300 33417-33425 NN denotes analysis
T16301 33426-33427 -LRB- denotes (
T16302 33427-33453 NN denotes http://jaspar.genereg.net/
T16303 33453-33454 -RRB- denotes )
T16304 33455-33464 VBD denotes predicted
T16305 33465-33470 CD denotes three
T16306 33471-33479 JJ denotes putative
T16307 33480-33485 NN denotes NF-κB
T16308 33486-33495 NNS denotes enhancers
T16309 33496-33498 IN denotes in
T16310 33499-33502 DT denotes the
T16311 33503-33511 JJ denotes proximal
T16312 33512-33520 NN denotes promoter
T16313 33521-33527 NN denotes region
T16314 33528-33530 IN denotes of
T16315 33531-33534 DT denotes the
T16316 33535-33541 JJ denotes MIP-1α
T16317 33542-33546 NN denotes gene
T16318 33546-33547 : denotes :
T16319 33548-33554 NN denotes NF-κB1
T16320 33554-33555 , denotes ,
T16321 33556-33557 VBP denotes −
T16322 33557-33561 CD denotes 1023
T16323 33561-33562 CD denotes /
T16324 33562-33563 NN denotes −
T16325 33563-33567 CD denotes 1014
T16326 33568-33579 NNS denotes nucleotides
T16327 33579-33580 : denotes ;
T16328 33581-33587 NNP denotes NF-κB2
T16329 33587-33588 , denotes ,
T16330 33589-33590 CD denotes −
T16331 33590-33593 CD denotes 661
T16332 33593-33594 NN denotes /
T16333 33594-33595 NN denotes −
T16334 33595-33598 CD denotes 652
T16335 33599-33610 NNS denotes nucleotides
T16336 33610-33611 : denotes ;
T16337 33612-33618 NNP denotes NF-κB3
T16338 33618-33619 , denotes ,
T16339 33620-33624 CD denotes +370
T16340 33624-33625 NN denotes /
T16341 33625-33629 CD denotes +379
T16342 33630-33641 NNS denotes nucleotides
T16343 33642-33643 -LRB- denotes (
T16344 33643-33656 NNP denotes Supplementary
T16345 33657-33663 NNP denotes Figure
T16346 33664-33667 NNP denotes S3A
T16347 33667-33668 -RRB- denotes )
T16348 33668-33669 . denotes .
T16349 33670-33672 TO denotes To
T16350 33673-33681 VB denotes validate
T16351 33682-33685 DT denotes the
T16352 33686-33695 VBN denotes predicted
T16353 33696-33701 NN denotes NF-κB
T16354 33702-33709 JJ denotes binding
T16355 33710-33715 NNS denotes sites
T16356 33716-33718 IN denotes of
T16357 33719-33722 DT denotes the
T16358 33723-33729 JJ denotes MIP-1α
T16359 33730-33738 NN denotes promoter
T16360 33738-33739 , denotes ,
T16361 33740-33742 PRP denotes we
T16362 33743-33753 VBD denotes stimulated
T16363 33754-33758 NNP denotes HeLa
T16364 33759-33764 NNS denotes cells
T16365 33765-33769 IN denotes with
T16366 33770-33775 NNP denotes TNF-α
T16367 33775-33776 , denotes ,
T16368 33777-33778 DT denotes a
T16369 33779-33789 JJ denotes well-known
T16370 33790-33795 NN denotes NF-κB
T16371 33796-33803 NN denotes inducer
T16372 33803-33804 , denotes ,
T16373 33805-33808 CC denotes and
T16374 33809-33817 VBD denotes measured
T16375 33818-33821 DT denotes the
T16376 33822-33832 NN denotes expression
T16377 33833-33839 NNS denotes levels
T16378 33840-33842 IN denotes of
T16379 33843-33849 NN denotes MIP-1α
T16380 33850-33852 IN denotes by
T16381 33853-33862 JJ denotes real-time
T16382 33863-33866 NNP denotes PCR
T16383 33866-33867 , denotes ,
T16384 33868-33871 CC denotes and
T16385 33872-33875 DT denotes the
T16386 33876-33879 NNS denotes p65
T16387 33880-33889 NN denotes occupancy
T16388 33890-33892 IN denotes of
T16389 33893-33896 DT denotes the
T16390 33897-33902 NNP denotes NF-κB
T16391 33903-33908 NNS denotes sites
T16392 33909-33911 IN denotes by
T16393 33912-33916 NNP denotes ChIP
T16394 33916-33917 . denotes .
T16395 33918-33923 JJ denotes TNF-α
T16396 33924-33933 VBN denotes activated
T16397 33934-33937 DT denotes the
T16398 33938-33948 NN denotes expression
T16399 33949-33951 IN denotes of
T16400 33952-33958 NN denotes MIP-1α
T16401 33959-33962 CC denotes and
T16402 33963-33970 VBD denotes induced
T16403 33971-33974 DT denotes the
T16404 33975-33978 CD denotes p65
T16405 33979-33990 NN denotes recruitment
T16406 33991-33993 TO denotes to
T16407 33994-33997 DT denotes the
T16408 33998-34004 JJ denotes NF-κB1
T16409 34005-34009 NN denotes site
T16410 34010-34012 IN denotes of
T16411 34013-34019 NN denotes MIP-1α
T16412 34020-34027 IN denotes without
T16413 34028-34037 VBG denotes affecting
T16414 34038-34041 DT denotes the
T16415 34042-34051 NN denotes occupancy
T16416 34052-34054 IN denotes of
T16417 34055-34058 DT denotes the
T16418 34059-34067 JJ denotes putative
T16419 34068-34074 NN denotes NF-κB2
T16420 34075-34078 CC denotes and
T16421 34079-34085 JJ denotes NF-κB3
T16422 34086-34091 NNS denotes sites
T16423 34092-34093 -LRB- denotes (
T16424 34093-34106 NNP denotes Supplementary
T16425 34107-34113 NNP denotes Figure
T16426 34114-34117 NNP denotes S3B
T16427 34118-34121 CC denotes and
T16428 34122-34125 NNP denotes S3C
T16429 34125-34126 -RRB- denotes )
T16430 34126-34127 . denotes .
T16431 34128-34131 NNP denotes Tat
T16432 34132-34136 RB denotes also
T16433 34137-34145 VBD denotes promoted
T16434 34146-34149 DT denotes the
T16435 34150-34161 NN denotes recruitment
T16436 34162-34164 IN denotes of
T16437 34165-34168 CD denotes p65
T16438 34169-34171 TO denotes to
T16439 34172-34175 DT denotes the
T16440 34176-34182 JJ denotes NF-κB1
T16441 34183-34187 NN denotes site
T16442 34188-34190 IN denotes of
T16443 34191-34197 NNP denotes MIP-1α
T16444 34197-34198 , denotes ,
T16445 34199-34204 IN denotes while
T16446 34205-34207 PRP denotes it
T16447 34208-34211 VBD denotes did
T16448 34212-34215 RB denotes not
T16449 34216-34222 VB denotes affect
T16450 34223-34226 DT denotes the
T16451 34227-34235 JJ denotes putative
T16452 34236-34242 NN denotes NF-κB2
T16453 34243-34246 CC denotes and
T16454 34247-34253 JJ denotes NF-κB3
T16455 34254-34259 NNS denotes sites
T16456 34260-34261 -LRB- denotes (
T16457 34261-34274 NNP denotes Supplementary
T16458 34275-34281 NNP denotes Figure
T16459 34282-34285 NNP denotes S3D
T16460 34285-34286 -RRB- denotes )
T16461 34286-34287 . denotes .
T16462 34288-34298 RB denotes Altogether
T16463 34299-34304 DT denotes these
T16464 34305-34312 NNS denotes results
T16465 34313-34322 VBD denotes indicated
T16466 34323-34327 IN denotes that
T16467 34328-34331 DT denotes the
T16468 34332-34338 JJ denotes NF-κB1
T16469 34339-34343 NN denotes site
T16470 34344-34347 VBD denotes was
T16471 34348-34351 DT denotes the
T16472 34352-34356 JJ denotes only
T16473 34357-34366 JJ denotes effective
T16474 34367-34372 NN denotes NF-κB
T16475 34373-34381 NN denotes enhancer
T16476 34382-34384 IN denotes of
T16477 34385-34388 DT denotes the
T16478 34389-34395 JJ denotes MIP-1α
T16479 34396-34404 NN denotes promoter
T16480 34405-34407 IN denotes in
T16481 34408-34416 NN denotes response
T16482 34417-34419 TO denotes to
T16483 34420-34425 NNP denotes TNF-α
T16484 34426-34429 CC denotes and
T16485 34430-34433 NNP denotes Tat
T16486 34433-34434 . denotes .
T16487 34435-34444 RB denotes Similarly
T16488 34445-34447 TO denotes to
T16489 34448-34454 NNP denotes MIP-1α
T16490 34454-34455 , denotes ,
T16491 34456-34459 NNP denotes Tat
T16492 34460-34469 VBD denotes increased
T16493 34470-34473 DT denotes the
T16494 34474-34485 NN denotes recruitment
T16495 34486-34488 IN denotes of
T16496 34489-34492 CD denotes p65
T16497 34493-34495 TO denotes to
T16498 34496-34499 DT denotes the
T16499 34500-34505 JJ denotes NF-κB
T16500 34506-34515 NNS denotes enhancers
T16501 34516-34518 IN denotes of
T16502 34519-34523 NNP denotes CSF3
T16503 34523-34524 , denotes ,
T16504 34525-34528 NNP denotes LTA
T16505 34528-34529 , denotes ,
T16506 34530-34536 NNP denotes NFKBIA
T16507 34537-34540 CC denotes and
T16508 34541-34545 NNP denotes TLR2
T16509 34545-34546 , denotes ,
T16510 34547-34552 IN denotes while
T16511 34553-34555 PRP denotes it
T16512 34556-34559 VBD denotes was
T16513 34560-34571 JJ denotes ineffective
T16514 34572-34574 IN denotes at
T16515 34575-34578 DT denotes the
T16516 34579-34588 NNS denotes promoters
T16517 34589-34591 IN denotes of
T16518 34592-34597 NNP denotes GAPDH
T16519 34598-34601 CC denotes and
T16520 34602-34606 NNP denotes ACTB
T16521 34607-34608 -LRB- denotes (
T16522 34608-34614 NNP denotes Figure
T16523 34615-34617 NNP denotes 5H
T16524 34617-34618 -RRB- denotes )
T16525 34618-34619 . denotes .
T16526 34620-34622 IN denotes By
T16527 34623-34627 NNP denotes ChIP
T16528 34627-34628 , denotes ,
T16529 34629-34632 NNP denotes Tat
T16530 34633-34638 VBD denotes bound
T16531 34639-34641 TO denotes to
T16532 34642-34645 DT denotes the
T16533 34646-34662 JJ denotes NF-κB-responsive
T16534 34663-34672 NNS denotes promoters
T16535 34672-34673 , denotes ,
T16536 34674-34677 CC denotes and
T16537 34678-34681 RB denotes not
T16538 34682-34684 TO denotes to
T16539 34685-34688 DT denotes the
T16540 34689-34694 NNP denotes GAPDH
T16541 35067-35076 VBD denotes displaced
T16542 34695-34698 CC denotes and
T16543 34699-34703 NNP denotes ACTB
T16544 34704-34713 NNS denotes promoters
T16545 34713-34714 , denotes ,
T16546 34715-34719 IN denotes with
T16547 34720-34724 NN denotes loss
T16548 34725-34727 IN denotes of
T16549 34728-34735 JJ denotes binding
T16550 34736-34745 VBG denotes following
T16551 34746-34749 CD denotes p65
T16552 34750-34753 NNP denotes RNA
T16553 34754-34766 NN denotes interference
T16554 34767-34768 -LRB- denotes (
T16555 34768-34774 NNP denotes Figure
T16556 34775-34777 NNP denotes 5I
T16557 34777-34778 -RRB- denotes )
T16558 34778-34779 , denotes ,
T16559 34780-34790 VBG denotes suggesting
T16560 34791-34795 IN denotes that
T16561 34796-34799 NNP denotes Tat
T16562 34800-34809 NN denotes occupancy
T16563 34810-34818 VBD denotes occurred
T16564 34819-34822 IN denotes via
T16565 34823-34826 CD denotes p65
T16566 34827-34838 NN denotes interaction
T16567 34838-34839 . denotes .
T16568 34840-34842 IN denotes As
T16569 34843-34853 JJ denotes additional
T16570 34854-34862 NNS denotes findings
T16571 34862-34863 , denotes ,
T16572 34864-34869 NNP denotes IκB-α
T16573 34870-34873 VBD denotes was
T16574 34874-34902 VBN denotes chromatin-immunoprecipitated
T16575 34903-34905 IN denotes at
T16576 34906-34909 DT denotes the
T16577 34910-34915 JJ denotes NF-κB
T16578 34916-34925 NNS denotes enhancers
T16579 34926-34928 IN denotes in
T16580 34929-34936 NN denotes absence
T16581 34937-34939 IN denotes of
T16582 34940-34943 NNP denotes Tat
T16583 34943-34944 , denotes ,
T16584 34945-34948 CC denotes and
T16585 34949-34951 PRP denotes it
T16586 34952-34955 VBD denotes was
T16587 34956-34969 RB denotes significantly
T16588 34970-34977 VBN denotes removed
T16589 34978-34980 IN denotes in
T16590 34981-34989 NN denotes presence
T16591 34990-34992 IN denotes of
T16592 34993-34996 NNP denotes Tat
T16593 34996-34997 , denotes ,
T16594 34998-35000 CC denotes or
T16595 35001-35010 VBG denotes following
T16596 35011-35016 NNP denotes IκB-α
T16597 35017-35020 NNP denotes RNA
T16598 35021-35033 NN denotes interference
T16599 35034-35035 -LRB- denotes (
T16600 35035-35041 NN denotes Figure
T16601 35042-35044 CD denotes 5J
T16602 35044-35045 -RRB- denotes )
T16603 35045-35046 , denotes ,
T16604 35047-35057 VBG denotes indicating
T16605 35058-35062 IN denotes that
T16606 35063-35066 NNP denotes Tat
T16607 35077-35082 NNP denotes IκB-α
T16608 35083-35087 IN denotes from
T16609 35088-35097 NNS denotes promoters
T16610 35097-35098 . denotes .
T18292 35100-35102 IN denotes In
T18293 35103-35117 JJ denotes HIV-1-infected
T18294 35118-35127 NNS denotes monocytes
T18295 35128-35131 NNP denotes Tat
T18296 35132-35140 VBZ denotes sustains
T18297 35141-35144 DT denotes the
T18298 35145-35150 JJ denotes NF-κB
T18299 35151-35159 NN denotes activity
T18300 35160-35163 CC denotes and
T18301 35164-35172 VBZ denotes promotes
T18302 35173-35176 DT denotes the
T18303 35177-35192 JJ denotes transcriptional
T18304 35193-35203 NN denotes activation
T18305 35204-35206 IN denotes of
T18306 35207-35213 NN denotes MIP-1α
T18307 35214-35216 IN denotes by
T18308 35217-35228 VBG denotes interacting
T18309 35229-35233 IN denotes with
T18310 35234-35239 NNP denotes IκB-α
T18311 35240-35243 CC denotes and
T18312 35244-35247 CD denotes p65
T18313 35248-35250 PRP denotes We
T18314 35251-35255 JJ denotes next
T18315 35256-35264 JJ denotes analysed
T18316 35265-35272 IN denotes whether
T18317 35273-35276 NNP denotes Tat
T18318 35277-35285 VBD denotes affected
T18319 35286-35289 DT denotes the
T18320 35290-35295 JJ denotes NF-κB
T18321 35296-35304 NN denotes activity
T18322 35305-35308 CC denotes and
T18323 35309-35312 DT denotes the
T18324 35313-35323 NN denotes expression
T18325 35324-35326 IN denotes of
T18326 35327-35333 NN denotes MIP-1α
T18327 35334-35336 IN denotes in
T18328 35337-35340 DT denotes the
T18329 35341-35347 NN denotes course
T18330 35348-35350 IN denotes of
T18331 35351-35356 JJ denotes HIV-1
T18332 35357-35366 NN denotes infection
T18333 35366-35367 . denotes .
T18334 35368-35370 TO denotes To
T18335 35371-35377 VB denotes detect
T18336 35378-35381 DT denotes the
T18337 35382-35385 NNP denotes Tat
T18338 35386-35393 NN denotes protein
T18339 35393-35394 , denotes ,
T18340 35395-35397 PRP denotes we
T18341 35398-35406 VBD denotes produced
T18342 35407-35411 NNP denotes HXB2
T18343 35412-35427 NNP denotes Env-pseudotyped
T18344 35428-35433 NNP denotes NL4-3
T18345 35433-35434 . denotes .
T18346 35434-35442 NN denotes FLAG-Tat
T18347 35442-35443 . denotes .
T18348 35443-35444 NN denotes R
T18349 35444-35445 NN denotes −
T18350 35445-35446 NNP denotes E
T18351 35446-35447 CD denotes −
T18352 35448-35455 NNS denotes virions
T18353 35455-35456 , denotes ,
T18354 35457-35462 WDT denotes which
T18355 35463-35467 VBD denotes were
T18356 35468-35472 VBN denotes used
T18357 35473-35475 IN denotes in
T18358 35476-35488 JJ denotes single-round
T18359 35489-35498 NN denotes infection
T18360 35499-35501 IN denotes of
T18361 35502-35506 NNP denotes U937
T18362 35506-35507 , denotes ,
T18363 35508-35509 DT denotes a
T18364 35510-35515 JJ denotes human
T18365 35516-35525 JJ denotes monocytic
T18366 35526-35530 NN denotes cell
T18367 35531-35535 NN denotes line
T18368 35535-35536 . denotes .
T18369 35537-35542 NNS denotes Cells
T18370 35543-35547 VBD denotes were
T18371 35548-35559 VBN denotes transfected
T18372 35560-35564 IN denotes with
T18373 35565-35570 NNP denotes siRNA
T18374 35571-35574 NNP denotes Tat
T18375 35574-35575 , denotes ,
T18376 35576-35581 NNP denotes siRNA
T18377 35582-35589 NN denotes control
T18378 35590-35592 CC denotes or
T18379 35593-35597 VBD denotes left
T18380 35598-35611 JJ denotes untransfected
T18381 35612-35614 TO denotes to
T18382 35615-35623 VB denotes modulate
T18383 35624-35627 DT denotes the
T18384 35628-35631 NNP denotes Tat
T18385 35632-35642 NN denotes expression
T18386 35642-35643 , denotes ,
T18387 35644-35647 CC denotes and
T18388 35648-35652 RB denotes then
T18389 35653-35661 VBD denotes analysed
T18390 35662-35665 IN denotes for
T18391 35666-35669 DT denotes the
T18392 35670-35677 NN denotes kinetic
T18393 35678-35680 IN denotes of
T18394 35681-35686 JJ denotes NF-κB
T18395 35687-35697 NN denotes activation
T18396 35698-35707 VBG denotes following
T18397 35708-35713 JJ denotes viral
T18398 35714-35723 NN denotes infection
T18399 35723-35724 . denotes .
T18400 35725-35728 DT denotes The
T18401 35729-35739 NN denotes expression
T18402 35740-35742 IN denotes of
T18403 35743-35746 NNP denotes Tat
T18404 35747-35750 CC denotes and
T18405 35751-35754 CD denotes p24
T18406 35755-35758 VBD denotes was
T18407 35759-35767 VBN denotes detected
T18408 35768-35770 IN denotes at
T18409 35771-35772 LS denotes 3
T18410 35772-35773 : denotes -
T18411 35774-35776 TO denotes to
T18412 35777-35781 JJ denotes 12-h
T18413 35782-35796 NN denotes post-infection
T18414 35796-35797 , denotes ,
T18415 35798-35803 IN denotes while
T18416 35804-35806 PRP denotes it
T18417 35807-35810 VBD denotes was
T18418 35811-35817 RB denotes barely
T18419 35818-35826 VBN denotes detected
T18420 35827-35829 IN denotes in
T18421 35830-35835 NNP denotes siRNA
T18422 35836-35851 VBD denotes Tat-transfected
T18423 35852-35857 NNS denotes cells
T18424 35858-35859 -LRB- denotes (
T18425 35859-35865 NN denotes Figure
T18426 35866-35868 NN denotes 6A
T18427 35868-35869 -RRB- denotes )
T18428 35869-35870 . denotes .
T18429 38126-38129 DT denotes The
T18430 38130-38135 JJ denotes NF-κB
T18431 38136-38144 NN denotes activity
T18432 38144-38145 , denotes ,
T18433 38146-38148 IN denotes as
T18434 38149-38157 VBN denotes measured
T18435 38158-38160 IN denotes by
T18436 38161-38164 CD denotes p65
T18437 38165-38168 NNP denotes DNA
T18438 38169-38176 JJ denotes binding
T18439 38176-38177 , denotes ,
T18440 38178-38181 VBD denotes was
T18441 38182-38189 VBN denotes induced
T18442 38190-38192 IN denotes at
T18443 38193-38196 JJ denotes 3-h
T18444 38197-38211 NN denotes post-infection
T18445 38212-38214 IN denotes in
T18446 38215-38219 DT denotes both
T18447 38220-38232 JJ denotes Tat-positive
T18448 38233-38234 -LRB- denotes (
T18449 38234-38236 DT denotes no
T18450 38237-38242 NN denotes siRNA
T18451 38243-38246 CC denotes and
T18452 38247-38252 NN denotes siRNA
T18453 38253-38260 NN denotes control
T18454 38260-38261 -RRB- denotes )
T18455 38262-38265 CC denotes and
T18456 38266-38278 JJ denotes Tat-negative
T18457 38279-38284 NNS denotes cells
T18458 38285-38286 -LRB- denotes (
T18459 38286-38291 NNP denotes siRNA
T18460 38292-38295 NNP denotes Tat
T18461 38295-38296 -RRB- denotes )
T18462 38296-38297 , denotes ,
T18463 38298-38301 CC denotes and
T18464 38302-38311 VBD denotes increased
T18465 38312-38314 IN denotes at
T18466 38315-38317 CD denotes 12
T18467 38318-38319 NN denotes h
T18468 38320-38324 RB denotes only
T18469 38325-38327 IN denotes in
T18470 38328-38340 JJ denotes Tat-positive
T18471 38341-38346 NNS denotes cells
T18472 38347-38348 -LRB- denotes (
T18473 38348-38354 NN denotes Figure
T18474 38355-38357 NN denotes 6B
T18475 38357-38358 -RRB- denotes )
T18476 38358-38359 . denotes .
T18477 38360-38371 NN denotes Degradation
T18478 38372-38374 IN denotes of
T18479 38375-38380 NNP denotes IκB-α
T18480 38381-38384 VBD denotes was
T18481 38385-38393 VBN denotes observed
T18482 38394-38396 IN denotes at
T18483 38397-38400 JJ denotes 3-h
T18484 38401-38415 NN denotes post-infection
T18485 38415-38416 , denotes ,
T18486 38417-38420 CC denotes and
T18487 38421-38424 VBD denotes was
T18488 38425-38433 VBN denotes followed
T18489 38434-38436 IN denotes by
T18490 38437-38439 FW denotes de
T18491 38440-38444 FW denotes novo
T18492 38445-38454 NN denotes synthesis
T18493 38455-38457 IN denotes of
T18494 38458-38463 NNP denotes IκB-α
T18495 38464-38466 IN denotes at
T18496 38467-38469 CD denotes 12
T18497 38470-38471 NN denotes h
T18498 38472-38485 RB denotes independently
T18499 38486-38488 IN denotes of
T18500 38489-38492 DT denotes the
T18501 38493-38496 NNP denotes Tat
T18502 38497-38505 NN denotes presence
T18503 38506-38507 -LRB- denotes (
T18504 38507-38513 NN denotes Figure
T18505 38514-38516 NN denotes 6C
T18506 38516-38517 -RRB- denotes )
T18507 38517-38518 . denotes .
T18508 38519-38531 RB denotes Consistently
T18509 38531-38532 , denotes ,
T18510 38533-38536 DT denotes the
T18511 38537-38540 NNP denotes IKK
T18512 38541-38549 NN denotes activity
T18513 38550-38553 VBD denotes was
T18514 38554-38561 VBN denotes induced
T18515 38562-38564 IN denotes at
T18516 38565-38568 JJ denotes 3-h
T18517 38569-38583 NN denotes post-infection
T18518 38584-38587 CC denotes and
T18519 38588-38594 VBD denotes turned
T18520 38595-38598 RP denotes off
T18521 38599-38601 IN denotes at
T18522 38602-38604 CD denotes 12
T18523 38605-38606 NN denotes h
T18524 38607-38620 RB denotes independently
T18525 38621-38623 IN denotes of
T18526 38624-38627 DT denotes the
T18527 38628-38631 NNP denotes Tat
T18528 38632-38640 NN denotes presence
T18529 38641-38642 -LRB- denotes (
T18530 38642-38648 NN denotes Figure
T18531 38649-38651 CD denotes 6D
T18532 38651-38652 -RRB- denotes )
T18533 38652-38653 . denotes .
T18534 38654-38659 DT denotes These
T18535 38660-38667 NNS denotes results
T18536 38668-38674 VBD denotes agreed
T18537 38675-38679 IN denotes with
T18538 38680-38683 DT denotes the
T18539 38684-38691 NN denotes kinetic
T18540 38692-38694 IN denotes of
T18541 38695-38700 JJ denotes NF-κB
T18542 38701-38711 NN denotes activation
T18543 38712-38714 IN denotes in
T18544 38715-38727 JJ denotes single-round
T18545 38728-38733 JJ denotes HIV-1
T18546 38734-38743 NN denotes infection
T18547 38744-38746 IN denotes of
T18548 38747-38753 NNP denotes Jurkat
T18549 38754-38759 NNS denotes cells
T18550 38760-38761 -LRB- denotes (
T18551 38761-38767 NN denotes Figure
T18552 38768-38769 CD denotes 1
T18553 38769-38770 -RRB- denotes )
T18554 38770-38771 , denotes ,
T18555 38772-38775 CC denotes and
T18556 38776-38783 JJ denotes further
T18557 38784-38793 VBD denotes supported
T18558 38794-38797 DT denotes the
T18559 38798-38809 NN denotes requirement
T18560 38810-38812 IN denotes of
T18561 38813-38818 JJ denotes viral
T18562 38819-38829 NN denotes expression
T18563 38830-38832 TO denotes to
T18564 38833-38843 VB denotes counteract
T18565 38844-38847 DT denotes the
T18566 38848-38863 NN denotes post-activation
T18567 38864-38868 VB denotes turn
T18568 38869-38872 RB denotes off
T18569 38873-38875 IN denotes of
T18570 38876-38881 NN denotes NF-κB
T18571 38881-38882 . denotes .
T18572 38883-38885 IN denotes In
T18573 38886-38900 JJ denotes HIV-1-infected
T18574 38901-38905 NNP denotes U937
T18575 38906-38911 NNS denotes cells
T18576 38911-38912 , denotes ,
T18577 38913-38916 DT denotes the
T18578 38917-38927 JJ denotes endogenous
T18579 38928-38931 NNP denotes Tat
T18580 38932-38935 VBD denotes was
T18581 38936-38956 VBN denotes coimmunoprecipitated
T18582 38957-38961 IN denotes with
T18583 38962-38967 NNP denotes IκB-α
T18584 38968-38971 CC denotes and
T18585 38972-38975 NNS denotes p65
T18586 38976-38977 -LRB- denotes (
T18587 38977-38983 NN denotes Figure
T18588 38984-38986 CD denotes 6E
T18589 38986-38987 -RRB- denotes )
T18590 38987-38988 , denotes ,
T18591 38989-38992 CC denotes and
T18592 38993-39002 VBD denotes activated
T18593 39003-39006 DT denotes the
T18594 39007-39013 JJ denotes MIP-1α
T18595 39014-39024 NN denotes expression
T18596 39025-39027 IN denotes in
T18597 39028-39029 DT denotes a
T18598 39030-39043 JJ denotes p65-dependent
T18599 39044-39050 NN denotes manner
T18600 39050-39051 , denotes ,
T18601 39052-39054 IN denotes as
T18602 39055-39060 VBN denotes shown
T18603 39061-39063 IN denotes by
T18604 39064-39067 DT denotes the
T18605 39068-39072 NN denotes lack
T18606 39073-39075 IN denotes of
T18607 39076-39082 NN denotes effect
T18608 39083-39092 VBG denotes following
T18609 39093-39096 NNP denotes RNA
T18610 39097-39109 NN denotes interference
T18611 39110-39112 IN denotes of
T18612 39113-39116 NNP denotes Tat
T18613 39117-39119 CC denotes or
T18614 39120-39123 CD denotes p65
T18615 39124-39125 -LRB- denotes (
T18616 39125-39131 NN denotes Figure
T18617 39132-39134 CD denotes 6F
T18618 39134-39135 -RRB- denotes )
T18619 39135-39136 . denotes .
T18620 39137-39145 RB denotes Moreover
T18621 39145-39146 , denotes ,
T18622 39147-39150 NNP denotes Tat
T18623 39151-39154 CC denotes and
T18624 39155-39158 NNS denotes p65
T18625 39159-39163 VBD denotes were
T18626 39164-39168 DT denotes both
T18627 39169-39178 VBN denotes recruited
T18628 39179-39181 TO denotes to
T18629 39182-39185 DT denotes the
T18630 39186-39191 JJ denotes NF-κB
T18631 39192-39200 NN denotes enhancer
T18632 39201-39203 IN denotes of
T18633 39204-39210 NNP denotes MIP-1α
T18634 39210-39211 , denotes ,
T18635 39212-39217 IN denotes while
T18636 39218-39221 DT denotes the
T18637 39222-39225 CD denotes p65
T18638 39226-39235 NN denotes occupancy
T18639 39236-39239 VBD denotes was
T18640 39240-39249 VBN denotes abolished
T18641 39250-39252 IN denotes by
T18642 39253-39258 NNP denotes siRNA
T18643 39259-39262 NNP denotes Tat
T18644 39263-39264 -LRB- denotes (
T18645 39264-39270 NNP denotes Figure
T18646 39271-39273 NNP denotes 6G
T18647 39274-39277 CC denotes and
T18648 39278-39279 NNP denotes H
T18649 39279-39280 -RRB- denotes )
T18650 39280-39281 . denotes .
T18651 39282-39292 RB denotes Altogether
T18652 39293-39298 DT denotes these
T18653 39299-39306 NNS denotes results
T18654 39307-39316 VBD denotes indicated
T18655 39317-39321 IN denotes that
T18656 39322-39324 IN denotes in
T18657 39325-39331 JJ denotes single
T18658 39332-39337 NN denotes round
T18659 39338-39343 NN denotes HIV-1
T18660 39344-39353 NN denotes infection
T18661 39354-39357 NNP denotes Tat
T18662 39358-39368 VBN denotes associated
T18663 39369-39373 IN denotes with
T18664 39374-39379 NNP denotes IκB-α
T18665 39380-39383 CC denotes and
T18666 39384-39387 CD denotes p65
T18667 39387-39388 , denotes ,
T18668 39389-39392 CC denotes and
T18669 39393-39400 VBD denotes induced
T18670 39401-39404 DT denotes the
T18671 39405-39418 JJ denotes p65-dependent
T18672 39419-39429 NN denotes activation
T18673 39430-39432 IN denotes of
T18674 39433-39439 JJ denotes MIP-1α
T18675 39440-39450 NN denotes expression
T18676 39451-39458 IN denotes through
T18677 39459-39468 NN denotes occupancy
T18678 39469-39471 IN denotes of
T18679 39472-39475 DT denotes the
T18680 39476-39482 JJ denotes MIP-1α
T18681 39483-39491 NN denotes promoter
T18682 39492-39495 CC denotes and
T18683 39496-39505 VBD denotes increased
T18684 39506-39517 NN denotes recruitment
T18685 39518-39520 IN denotes of
T18686 39521-39524 NNS denotes p65
T18687 39524-39525 . denotes .
T21240 39538-39542 DT denotes This
T21241 39543-39548 NN denotes study
T21242 39549-39556 VBZ denotes reports
T21243 39557-39558 DT denotes a
T21244 39559-39564 NN denotes novel
T21245 39565-39574 NN denotes mechanism
T21246 39575-39577 IN denotes of
T21247 39578-39583 JJ denotes NF-κB
T21248 39584-39594 NN denotes activation
T21249 39595-39597 IN denotes by
T21250 39598-39601 DT denotes the
T21251 39602-39607 NNP denotes HIV-1
T21252 39608-39611 NNP denotes Tat
T21253 39612-39626 NN denotes transactivator
T21254 39626-39627 . denotes .
T21255 39628-39633 VBN denotes Based
T21256 39634-39636 IN denotes on
T21257 39637-39640 DT denotes the
T21258 39641-39649 NN denotes evidence
T21259 39650-39654 IN denotes that
T21260 39655-39658 NNP denotes Tat
T21261 39659-39667 VBD denotes enhanced
T21262 39668-39671 DT denotes the
T21263 39672-39687 JJ denotes transcriptional
T21264 39688-39696 NN denotes activity
T21265 39697-39699 IN denotes of
T21266 39700-39703 DT denotes the
T21267 39704-39707 CD denotes p65
T21268 39708-39715 NN denotes subunit
T21269 39716-39718 IN denotes of
T21270 39719-39724 NNP denotes NF-κB
T21271 39725-39726 -LRB- denotes (
T21272 39726-39734 CD denotes 49,63,64
T21273 39734-39735 -RRB- denotes )
T21274 39735-39736 , denotes ,
T21275 39737-39740 CC denotes and
T21276 39741-39751 RB denotes physically
T21277 39752-39762 VBN denotes interacted
T21278 39763-39767 IN denotes with
T21279 39768-39771 DT denotes the
T21280 39772-39777 JJ denotes IκB-α
T21281 39778-39787 NN denotes repressor
T21282 39788-39789 -LRB- denotes (
T21283 39789-39794 CD denotes 50,51
T21284 39794-39795 -RRB- denotes )
T21285 39795-39796 , denotes ,
T21286 39797-39799 PRP denotes we
T21287 39800-39812 VBD denotes investigated
T21288 39813-39816 DT denotes the
T21289 39817-39828 NN denotes possibility
T21290 39829-39833 WDT denotes that
T21291 39834-39837 NNP denotes Tat
T21292 39838-39843 MD denotes could
T21293 39844-39852 VB denotes activate
T21294 39853-39858 NNP denotes NF-κB
T21295 39859-39862 IN denotes via
T21296 39863-39869 JJ denotes direct
T21297 39870-39881 NN denotes interaction
T21298 39882-39886 IN denotes with
T21299 39887-39892 NNP denotes IκB-α
T21300 39893-39896 CC denotes and
T21301 39897-39900 NNS denotes p65
T21302 39900-39901 . denotes .
T21303 39902-39904 TO denotes To
T21304 39905-39909 DT denotes this
T21305 39910-39913 NN denotes end
T21306 39913-39914 , denotes ,
T21307 39915-39918 DT denotes the
T21308 39919-39924 NN denotes NF-κB
T21309 39925-39933 NN denotes activity
T21310 39934-39937 VBD denotes was
T21311 39938-39947 VBN denotes monitored
T21312 39948-39950 IN denotes in
T21313 39951-39957 JJ denotes single
T21314 39958-39963 NN denotes round
T21315 39964-39969 NN denotes HIV-1
T21316 39970-39979 NN denotes infection
T21317 39980-39985 VBG denotes using
T21318 39986-39989 NNP denotes RNA
T21319 39990-40002 NN denotes interference
T21320 40003-40005 TO denotes to
T21321 40006-40013 NN denotes silence
T21322 40014-40017 DT denotes the
T21323 40018-40021 NNP denotes Tat
T21324 40022-40032 NN denotes expression
T21325 40032-40033 . denotes .
T21326 40034-40036 IN denotes By
T21327 40037-40041 DT denotes this
T21328 40042-40050 NN denotes approach
T21329 40050-40051 , denotes ,
T21330 40052-40054 PRP denotes we
T21331 40055-40062 VBD denotes avoided
T21332 40063-40066 DT denotes the
T21333 40067-40079 NN denotes perpetuation
T21334 40080-40082 IN denotes of
T21335 40083-40088 JJ denotes NF-κB
T21336 40089-40099 NN denotes activation
T21337 40100-40109 VBG denotes signaling
T21338 40110-40113 JJ denotes due
T21339 40114-40116 TO denotes to
T21340 40117-40127 JJ denotes subsequent
T21341 40128-40134 NNS denotes rounds
T21342 40135-40137 IN denotes of
T21343 40138-40143 JJ denotes viral
T21344 40144-40149 NN denotes entry
T21345 40150-40152 IN denotes in
T21346 40153-40157 NN denotes cell
T21347 40158-40165 NN denotes culture
T21348 40166-40177 NN denotes propagation
T21349 40178-40179 -LRB- denotes (
T21350 40179-40184 CD denotes 30,31
T21351 40184-40185 -RRB- denotes )
T21352 40185-40186 . denotes .
T21353 40187-40191 IN denotes Upon
T21354 40192-40197 JJ denotes HIV-1
T21355 40198-40207 NN denotes infection
T21356 40207-40208 , denotes ,
T21357 40209-40212 DT denotes the
T21358 40213-40218 JJ denotes early
T21359 40219-40224 NN denotes NF-κB
T21360 40225-40235 NN denotes activation
T21361 40236-40244 VBD denotes occurred
T21362 40245-40258 RB denotes concomitantly
T21363 40259-40263 IN denotes with
T21364 40264-40267 NNP denotes IKK
T21365 40268-40278 NN denotes activation
T21366 40279-40282 CC denotes and
T21367 40283-40288 JJ denotes IκB-α
T21368 40289-40300 NN denotes degradation
T21369 40301-40303 IN denotes in
T21370 40304-40307 DT denotes the
T21371 40308-40315 NN denotes absence
T21372 40316-40318 IN denotes of
T21373 40319-40322 NNP denotes Tat
T21374 40322-40323 . denotes .
T21375 40324-40328 RB denotes Soon
T21376 40329-40334 IN denotes after
T21377 40335-40338 DT denotes the
T21378 40339-40343 VBN denotes shut
T21379 40344-40347 IN denotes off
T21380 40348-40350 IN denotes of
T21381 40351-40354 NNP denotes IKK
T21382 40355-40363 NN denotes activity
T21383 40364-40367 CC denotes and
T21384 40368-40371 JJ denotes new
T21385 40372-40381 NN denotes synthesis
T21386 40382-40384 IN denotes of
T21387 40385-40390 NNP denotes IκB-α
T21388 40390-40391 , denotes ,
T21389 40392-40395 DT denotes the
T21390 40396-40401 NN denotes NF-κB
T21391 40402-40410 NN denotes activity
T21392 40411-40414 VBD denotes was
T21393 40415-40419 VBN denotes kept
T21394 40420-40428 VBN denotes elevated
T21395 40429-40431 IN denotes in
T21396 40432-40435 DT denotes the
T21397 40436-40444 NN denotes presence
T21398 40445-40447 IN denotes of
T21399 40448-40451 NNP denotes Tat
T21400 40451-40452 , denotes ,
T21401 40453-40458 IN denotes while
T21402 40459-40461 PRP denotes it
T21403 40462-40465 VBD denotes was
T21404 40466-40470 RB denotes down
T21405 40471-40480 VBN denotes regulated
T21406 40481-40485 IN denotes upon
T21407 40486-40495 VBG denotes silencing
T21408 40496-40498 IN denotes of
T21409 40499-40502 DT denotes the
T21410 40503-40506 NNP denotes Tat
T21411 40507-40511 NN denotes gene
T21412 40511-40512 . denotes .
T21413 40513-40518 DT denotes These
T21414 40519-40527 NNS denotes findings
T21415 40528-40536 VBP denotes indicate
T21416 40537-40541 IN denotes that
T21417 40542-40544 IN denotes in
T21418 40545-40551 JJ denotes single
T21419 40552-40557 NN denotes round
T21420 40558-40563 NN denotes HIV-1
T21421 40564-40573 NN denotes infection
T21422 40573-40574 , denotes ,
T21423 40575-40578 NNP denotes Tat
T21424 40579-40587 VBD denotes enhanced
T21425 40588-40591 DT denotes the
T21426 40592-40597 JJ denotes NF-κB
T21427 40598-40606 NN denotes activity
T21428 40607-40614 IN denotes without
T21429 40615-40624 VBG denotes affecting
T21430 40625-40628 DT denotes the
T21431 40629-40632 NNP denotes IKK
T21432 40633-40641 NN denotes activity
T21433 40642-40645 CC denotes and
T21434 40646-40649 DT denotes the
T21435 40650-40659 NN denotes half-life
T21436 40660-40662 IN denotes of
T21437 40663-40668 NNP denotes IκB-α
T21438 40668-40669 . denotes .
T21439 40670-40677 JJ denotes Similar
T21440 40678-40685 NN denotes kinetic
T21441 40686-40688 IN denotes of
T21442 40689-40694 JJ denotes NF-κB
T21443 40695-40705 NN denotes activation
T21444 40706-40714 VBD denotes occurred
T21445 40715-40719 IN denotes upon
T21446 40720-40731 NN denotes short-pulse
T21447 40732-40734 IN denotes of
T21448 40735-40738 NNP denotes PMA
T21449 40739-40741 IN denotes in
T21450 40742-40757 NNP denotes Tat-transfected
T21451 40758-40762 NNP denotes HeLa
T21452 40763-40768 NNS denotes cells
T21453 40768-40769 , denotes ,
T21454 40770-40775 WRB denotes where
T21455 40776-40779 NNP denotes Tat
T21456 40780-40789 VBD denotes inhibited
T21457 40790-40793 DT denotes the
T21458 40794-40809 JJ denotes post-activation
T21459 40810-40814 NN denotes turn
T21460 40815-40818 IN denotes off
T21461 40819-40821 IN denotes of
T21462 40822-40827 NN denotes NF-κB
T21463 40828-40830 IN denotes in
T21464 40831-40839 NN denotes presence
T21465 40840-40842 IN denotes of
T21466 40843-40848 RB denotes newly
T21467 40849-40860 VBN denotes synthesized
T21468 40861-40866 NNP denotes IκB-α
T21469 40866-40867 . denotes .
T21470 40868-40871 DT denotes The
T21471 40872-40885 JJ denotes Tat-dependent
T21472 40886-40896 NN denotes activation
T21473 40897-40899 IN denotes of
T21474 40900-40905 JJ denotes NF-κB
T21475 40906-40916 VBN denotes correlated
T21476 40917-40921 IN denotes with
T21477 40922-40925 DT denotes the
T21478 40926-40937 NN denotes association
T21479 40938-40940 IN denotes of
T21480 40941-40944 DT denotes the
T21481 40945-40950 JJ denotes viral
T21482 40951-40958 NN denotes protein
T21483 40959-40963 IN denotes with
T21484 40964-40969 NNP denotes IκB-α
T21485 40969-40970 , denotes ,
T21486 40971-40976 WDT denotes which
T21487 40977-40987 VBD denotes interfered
T21488 40988-40992 IN denotes with
T21489 40993-40996 DT denotes the
T21490 40997-41007 NN denotes generation
T21491 41008-41010 IN denotes of
T21492 41011-41014 DT denotes the
T21493 41015-41020 NNP denotes IκB-α
T21494 41020-41021 NNP denotes /
T21495 41021-41024 CD denotes p65
T21496 41025-41032 NN denotes complex
T21497 41032-41033 . denotes .
T21498 41034-41038 DT denotes This
T21499 41039-41047 NN denotes evidence
T21500 41048-41060 VBD denotes demonstrated
T21501 41061-41065 IN denotes that
T21502 41066-41069 NNP denotes Tat
T21503 41070-41078 VBD denotes competed
T21504 41079-41082 IN denotes for
T21505 41083-41086 DT denotes the
T21506 41087-41094 JJ denotes binding
T21507 41095-41097 IN denotes of
T21508 41098-41103 NNP denotes IκB-α
T21509 41104-41106 TO denotes to
T21510 41107-41110 VB denotes p65
T21511 41111-41114 CC denotes and
T21512 41115-41124 VBD denotes prevented
T21513 41125-41128 DT denotes the
T21514 41129-41134 JJ denotes IκB-α
T21515 41135-41145 NN denotes repression
T21516 41146-41148 IN denotes of
T21517 41149-41152 NNS denotes p65
T21518 41152-41153 . denotes .
T21519 41154-41156 IN denotes As
T21520 41157-41167 JJ denotes additional
T21521 41168-41177 NN denotes mechanism
T21522 41178-41180 IN denotes of
T21523 41181-41186 JJ denotes NF-κB
T21524 41187-41197 NN denotes activation
T21525 41197-41198 , denotes ,
T21526 41199-41202 NNP denotes Tat
T21527 41203-41213 VBN denotes associated
T21528 41214-41218 IN denotes with
T21529 41219-41222 NNS denotes p65
T21530 41223-41226 CC denotes and
T21531 41227-41236 VBD denotes increased
T21532 41237-41240 DT denotes the
T21533 41241-41244 CD denotes p65
T21534 41245-41252 JJ denotes binding
T21535 41253-41261 NN denotes affinity
T21536 41262-41264 TO denotes to
T21537 41265-41268 DT denotes the
T21538 41269-41274 JJ denotes NF-κB
T21539 41275-41283 NN denotes enhancer
T21540 41283-41284 : denotes ;
T21541 41285-41289 DT denotes this
T21542 41290-41298 NN denotes evidence
T21543 41299-41302 VBD denotes was
T21544 41303-41311 VBN denotes obtained
T21545 41312-41316 IN denotes with
T21546 41317-41328 JJ denotes recombinant
T21547 41329-41337 NNS denotes proteins
T21548 41338-41348 VBG denotes indicating
T21549 41349-41353 IN denotes that
T21550 41354-41357 DT denotes the
T21551 41358-41366 JJR denotes stronger
T21552 41367-41374 JJ denotes binding
T21553 41375-41377 IN denotes of
T21554 41378-41381 CD denotes p65
T21555 41382-41384 TO denotes to
T21556 41385-41388 NNP denotes DNA
T21557 41389-41392 VBD denotes was
T21558 41393-41394 DT denotes a
T21559 41395-41406 NN denotes consequence
T21560 41407-41409 IN denotes of
T21561 41410-41416 JJ denotes direct
T21562 41417-41428 NN denotes association
T21563 41429-41433 IN denotes with
T21564 41434-41437 NNP denotes Tat
T21565 41437-41438 , denotes ,
T21566 41439-41444 WDT denotes which
T21567 41445-41451 RB denotes likely
T21568 41452-41458 VBD denotes caused
T21569 41459-41460 DT denotes a
T21570 41461-41475 JJ denotes conformational
T21571 41476-41482 NN denotes change
T21572 41483-41485 IN denotes of
T21573 41486-41489 NNS denotes p65
T21574 41489-41490 . denotes .
T21575 41491-41493 PRP denotes We
T21576 41494-41498 RB denotes also
T21577 41499-41511 VBD denotes demonstrated
T21578 41512-41516 IN denotes that
T21579 41517-41520 DT denotes the
T21580 41521-41524 NNP denotes Tat
T21581 41525-41538 NN denotes cysteine-rich
T21582 41539-41547 NN denotes sequence
T21583 41548-41549 -LRB- denotes (
T21584 41549-41552 CD denotes C22
T21585 41552-41558 CD denotes ,25,27
T21586 41558-41559 -RRB- denotes )
T21587 41560-41563 VBD denotes was
T21588 41564-41572 VBN denotes involved
T21589 41573-41575 IN denotes in
T21590 41576-41579 DT denotes the
T21591 41580-41587 JJ denotes binding
T21592 41588-41590 TO denotes to
T21593 41591-41594 DT denotes the
T21594 41595-41598 NNP denotes RHD
T21595 41599-41601 IN denotes of
T21596 41602-41605 CD denotes p65
T21597 41606-41609 CC denotes and
T21598 41610-41615 NNP denotes NF-κB
T21599 41616-41626 NN denotes activation
T21600 41626-41627 . denotes .
T21601 41628-41639 RB denotes Differently
T21602 41639-41640 , denotes ,
T21603 41641-41644 DT denotes the
T21604 41645-41648 NNP denotes Tat
T21605 41649-41662 JJ denotes arginine-rich
T21606 41663-41671 NN denotes sequence
T21607 41672-41673 -LRB- denotes (
T21608 41673-41676 CD denotes R49
T21609 41676-41691 CD denotes ,52,53,55,56,57
T21610 41691-41692 -RRB- denotes )
T21611 41693-41696 VBD denotes was
T21612 41697-41705 VBN denotes required
T21613 41706-41709 IN denotes for
T21614 41710-41713 DT denotes the
T21615 41714-41721 JJ denotes binding
T21616 41722-41724 TO denotes to
T21617 41725-41728 DT denotes the
T21618 41729-41734 JJ denotes sixth
T21619 41735-41742 NN denotes ankyrin
T21620 41743-41745 IN denotes of
T21621 41746-41751 NNP denotes IκB-α
T21622 41752-41753 -LRB- denotes (
T21623 41753-41758 CD denotes 50,51
T21624 41758-41759 -RRB- denotes )
T21625 41759-41760 , denotes ,
T21626 41761-41764 CC denotes and
T21627 41765-41768 IN denotes for
T21628 41769-41778 VBG denotes releasing
T21673 42043-42053 NN denotes activation
T21674 42054-42056 IN denotes of
T21675 42057-42062 JJ denotes NF-κB
T21676 42063-42069 VBD denotes showed
T21677 42070-42074 IN denotes that
T21678 42075-42084 JJ denotes wild-type
T21679 42085-42088 NNP denotes Tat
T21680 42088-42089 , denotes ,
T21681 42090-42093 CC denotes and
T21682 42094-42097 RB denotes not
T21683 42098-42101 DT denotes the
T21684 42102-42105 NNP denotes Tat
T21685 42106-42113 NNS denotes mutants
T21686 42114-42121 VBG denotes lacking
T21687 42122-42125 DT denotes the
T21688 42126-42134 NN denotes arginine
T21689 42134-42135 : denotes -
T21690 42136-42138 CC denotes or
T21691 42139-42152 JJ denotes cysteine-rich
T21692 42153-42160 NNS denotes domains
T21693 42160-42161 , denotes ,
T21694 42162-42174 JJ denotes up-regulated
T21695 42175-42177 IN denotes in
T21696 42178-42182 NN denotes vivo
T21697 42183-42186 DT denotes the
T21698 42187-42197 NN denotes expression
T21699 42198-42200 IN denotes of
T21700 42201-42202 DT denotes a
T21701 42203-42209 NN denotes number
T21702 42210-42212 IN denotes of
T21703 42213-42229 JJ denotes NF-κB-responsive
T21704 42230-42235 NNS denotes genes
T21705 42235-42236 , denotes ,
T21706 42237-42246 VBG denotes including
T21707 42247-42253 NNP denotes MIP-1α
T21708 42253-42254 , denotes ,
T21709 42255-42259 NNP denotes CSF3
T21710 42259-42260 , denotes ,
T21711 42261-42264 NNP denotes LTA
T21712 42264-42265 , denotes ,
T21713 42266-42272 NNP denotes NFKBIA
T21714 42273-42276 CC denotes and
T21715 42277-42281 NNP denotes TLR2
T21716 42281-42282 . denotes .
T21717 42283-42285 IN denotes By
T21718 42286-42290 NNP denotes ChIP
T21719 42291-42299 NN denotes analysis
T21720 42299-42300 , denotes ,
T21721 42301-42303 PRP denotes we
T21722 42304-42312 VBD denotes observed
T21723 42313-42317 IN denotes that
T21724 42318-42321 NNP denotes Tat
T21725 42322-42331 VBD denotes increased
T21726 42332-42335 DT denotes the
T21727 42336-42347 NN denotes recruitment
T21728 42348-42350 IN denotes of
T21729 42351-42354 CD denotes p65
T21730 42355-42357 TO denotes to
T21731 42358-42361 DT denotes the
T21732 42362-42367 JJ denotes NF-κB
T21733 42368-42377 NNS denotes enhancers
T21734 42378-42380 IN denotes of
T21735 42381-42384 DT denotes the
T21736 42385-42394 VBN denotes activated
T21737 42395-42400 NNS denotes genes
T21738 42400-42401 , denotes ,
T21739 42402-42405 CC denotes and
T21740 42406-42409 VBD denotes was
T21741 42410-42419 VBN denotes recovered
T21742 42420-42422 IN denotes at
T21743 42423-42426 DT denotes the
T21744 42427-42431 JJ denotes same
T21745 42432-42437 NNS denotes sites
T21746 42437-42438 . denotes .
T21747 42439-42442 NNP denotes RNA
T21748 42443-42455 NN denotes interference
T21749 42456-42458 IN denotes of
T21750 42459-42462 CD denotes p65
T21751 42463-42472 VBD denotes abolished
T21752 42473-42476 DT denotes the
T21753 42477-42480 NNP denotes Tat
T21754 42481-42490 NN denotes occupancy
T21755 42491-42493 IN denotes of
T21756 42494-42497 DT denotes the
T21757 42498-42503 JJ denotes NF-κB
T21758 42504-42513 NNS denotes enhancers
T21759 42514-42524 VBG denotes indicating
T21760 42525-42529 IN denotes that
T21761 42530-42533 DT denotes the
T21762 42534-42537 NNP denotes Tat
T21763 42538-42545 JJ denotes binding
T21764 42546-42548 TO denotes to
T21765 42549-42552 DT denotes the
T21766 42553-42558 JJ denotes NF-κB
T21767 42559-42564 NNS denotes sites
T21768 42565-42568 VBD denotes was
T21769 42569-42577 VBN denotes mediated
T21770 42578-42580 IN denotes by
T21771 42581-42584 NNS denotes p65
T21772 42584-42585 . denotes .
T21773 42586-42591 DT denotes These
T21774 42592-42599 NNS denotes results
T21775 42600-42604 VBD denotes were
T21776 42605-42615 JJ denotes consistent
T21777 42616-42620 IN denotes with
T21778 42621-42624 DT denotes the
T21779 42625-42633 NN denotes evidence
T21780 42634-42638 IN denotes that
T21781 42639-42642 NNP denotes Tat
T21782 42643-42652 VBD denotes displaced
T21783 42653-42656 CD denotes p65
T21784 42657-42661 IN denotes from
T21785 42662-42665 DT denotes the
T21786 42666-42673 JJ denotes binding
T21787 42674-42676 TO denotes to
T21788 42677-42682 NNP denotes IκB-α
T21789 42683-42684 -LRB- denotes (
T21790 42684-42691 NNS denotes Figures
T21791 42692-42694 JJ denotes 2D
T21792 42695-42698 CC denotes and
T21793 42699-42701 NNP denotes 3C
T21794 42701-42702 -RRB- denotes )
T21795 42702-42703 , denotes ,
T21796 42704-42707 CC denotes and
T21797 42708-42717 VBD denotes increased
T21798 42718-42721 DT denotes the
T21799 42722-42725 CD denotes p65
T21800 42726-42729 NNP denotes DNA
T21801 42730-42737 JJ denotes binding
T21802 42738-42746 NN denotes affinity
T21803 42747-42754 IN denotes through
T21804 42755-42766 NN denotes association
T21805 42767-42768 -LRB- denotes (
T21806 42768-42774 NN denotes Figure
T21807 42775-42777 CD denotes 4E
T21808 42778-42781 CC denotes and
T21809 42782-42783 NN denotes F
T21810 42783-42784 -RRB- denotes )
T21811 42784-42785 . denotes .
T21812 42786-42790 RB denotes Thus
T21813 42790-42791 , denotes ,
T21814 42792-42795 NNP denotes Tat
T21815 42796-42802 JJ denotes likely
T21816 42803-42812 VBD denotes increased
T21817 42813-42816 DT denotes the
T21818 42817-42828 NN denotes recruitment
T21819 42829-42831 IN denotes of
T21820 42832-42835 CD denotes p65
T21821 42836-42838 TO denotes to
T21822 42839-42842 DT denotes the
T21823 42843-42858 JJ denotes NF-κB-dependent
T21824 42859-42868 NNS denotes promoters
T21825 42869-42871 IN denotes by
T21826 42872-42883 VBG denotes associating
T21827 42884-42888 IN denotes with
T21828 42889-42892 NNS denotes p65
T21829 42893-42896 CC denotes and
T21830 42897-42899 IN denotes by
T21831 42900-42911 VBG denotes interfering
T21832 42912-42916 IN denotes with
T21833 42917-42920 DT denotes the
T21834 42921-42929 NN denotes assembly
T21835 42930-42932 IN denotes of
T21836 42933-42936 NNS denotes p65
T21837 42937-42941 IN denotes with
T21838 42942-42945 DT denotes the
T21839 42946-42955 NN denotes repressor
T21840 42956-42961 NN denotes IκB-α
T21841 42961-42962 . denotes .
T21842 42963-42965 IN denotes Of
T21843 42966-42974 NN denotes interest
T21844 42974-42975 , denotes ,
T21845 42976-42981 NNP denotes IκB-α
T21846 42982-42985 VBD denotes was
T21847 42986-42991 VBN denotes found
T21848 42992-43002 VBN denotes associated
T21849 43003-43005 TO denotes to
T21850 43006-43009 DT denotes the
T21851 43010-43015 JJ denotes NF-κB
T21852 43016-43025 NNS denotes enhancers
T21853 43026-43028 IN denotes in
T21854 43029-43036 NN denotes absence
T21855 43037-43039 IN denotes of
T21856 43040-43043 NNP denotes Tat
T21857 43043-43044 , denotes ,
T21858 43045-43050 WRB denotes where
T21859 43051-43053 PRP denotes it
T21860 43054-43057 VBD denotes was
T21861 43058-43067 VBN denotes displaced
T21862 43068-43070 IN denotes in
T21863 43071-43079 NN denotes presence
T21864 43080-43082 IN denotes of
T21865 43083-43086 NNP denotes Tat
T21866 43086-43087 . denotes .
T21867 43088-43093 DT denotes These
T21868 43094-43101 NNS denotes results
T21869 43102-43109 VBP denotes suggest
T21870 43110-43111 DT denotes a
T21871 43112-43120 JJ denotes negative
T21872 43121-43131 JJ denotes regulatory
T21873 43132-43136 NN denotes role
T21874 43137-43139 IN denotes of
T21875 43140-43145 NNP denotes IκB-α
T21876 43146-43148 IN denotes in
T21877 43149-43153 NN denotes gene
T21878 43154-43164 NN denotes regulation
T21879 43165-43172 IN denotes through
T21880 43173-43182 NN denotes occupancy
T21881 43183-43185 IN denotes of
T21882 43186-43194 JJ denotes specific
T21883 43195-43204 NNS denotes promoters
T21884 43204-43205 . denotes .
T21885 43206-43212 RB denotes Indeed
T21886 43212-43213 , denotes ,
T21887 43214-43219 NNP denotes IκB-α
T21888 43220-43223 VBD denotes was
T21889 43224-43229 VBN denotes found
T21890 43230-43240 VBN denotes associated
T21891 43241-43245 IN denotes with
T21892 43246-43253 NN denotes hystone
T21893 43254-43266 NNS denotes deacetylases
T21894 43267-43269 IN denotes at
T21895 43270-43273 DT denotes the
T21896 43274-43278 CD denotes hes1
T21897 43279-43287 NN denotes promoter
T21898 43287-43288 , denotes ,
T21899 43289-43293 IN denotes from
T21900 43294-43299 WRB denotes where
T21901 43300-43302 PRP denotes it
T21902 43303-43306 VBD denotes was
T21903 43307-43314 VBN denotes removed
T21904 43315-43324 VBG denotes following
T21905 43325-43330 JJ denotes TNF-α
T21906 43331-43342 NN denotes stimulation
T21907 43343-43350 VBG denotes causing
T21908 43351-43358 NN denotes histone
T21909 43359-43370 NN denotes acetylation
T21910 43371-43374 CC denotes and
T21911 43375-43379 CD denotes hes1
T21912 43380-43395 JJ denotes transcriptional
T21913 43396-43406 NN denotes activation
T21914 43407-43408 -LRB- denotes (
T21915 43408-43410 CD denotes 65
T21916 43410-43411 -RRB- denotes )
T21917 43411-43412 . denotes .
T21918 43413-43414 DT denotes A
T21919 43415-43422 JJ denotes similar
T21920 43423-43432 NN denotes mechanism
T21921 43433-43435 IN denotes of
T21922 43436-43440 NN denotes gene
T21923 43441-43451 NN denotes regulation
T21924 43452-43457 MD denotes could
T21925 43458-43463 VB denotes apply
T21926 43464-43466 TO denotes to
T21927 43467-43470 DT denotes the
T21928 43471-43486 JJ denotes NF-κB-dependent
T21929 43487-43492 NNS denotes genes
T21930 43493-43501 VBN denotes analysed
T21931 43502-43504 IN denotes in
T21932 43505-43509 DT denotes this
T21933 43510-43515 NN denotes study
T21934 43515-43516 , denotes ,
T21935 43517-43522 WRB denotes where
T21936 43523-43526 NNP denotes Tat
T21937 43527-43532 MD denotes could
T21938 43533-43541 VB denotes activate
T21939 43542-43545 DT denotes the
T21940 43546-43550 NN denotes gene
T21941 43551-43561 NN denotes expression
T21942 43562-43564 IN denotes by
T21943 43565-43573 VBG denotes removing
T21944 43574-43579 NNP denotes IκB-α
T21945 43580-43583 CC denotes and
T21946 43584-43593 VBG denotes promoting
T21947 43594-43597 DT denotes the
T21948 43598-43601 CD denotes p65
T21949 43602-43609 VBG denotes loading
T21950 43610-43611 -LRB- denotes (
T21951 43611-43617 NN denotes Figure
T21952 43618-43619 CD denotes 7
T21953 43619-43620 -RRB- denotes )
T21954 43620-43621 . denotes .
T21955 44045-44048 DT denotes The
T21956 44049-44062 JJ denotes physiological
T21957 44063-44072 NN denotes relevance
T21958 44073-44075 IN denotes of
T21959 44076-44079 NNP denotes Tat
T21960 44080-44085 VBP denotes cross
T21961 44086-44090 NN denotes talk
T21962 44091-44095 IN denotes with
T21963 44096-44101 NN denotes NF-κB
T21964 44102-44105 VBD denotes was
T21965 44106-44118 VBN denotes demonstrated
T21966 44119-44121 IN denotes in
T21967 44122-44125 DT denotes the
T21968 44126-44131 NNP denotes HIV-1
T21969 44132-44141 NN denotes infection
T21970 44142-44144 IN denotes of
T21971 44145-44150 JJ denotes human
T21972 44151-44160 NNS denotes monocytes
T21973 44160-44161 , denotes ,
T21974 44162-44167 WRB denotes where
T21975 44168-44181 JJ denotes HIV-1-encoded
T21976 44182-44185 NNP denotes Tat
T21977 44186-44193 NN denotes protein
T21978 44194-44206 VBD denotes counteracted
T21979 44207-44222 JJ denotes post-activation
T21980 44223-44227 NN denotes turn
T21981 44228-44231 IN denotes off
T21982 44232-44234 IN denotes of
T21983 44235-44240 NNP denotes NF-κB
T21984 44240-44241 , denotes ,
T21985 44242-44244 IN denotes as
T21986 44245-44250 VBN denotes shown
T21987 44251-44253 IN denotes by
T21988 44253-44254 : denotes :
T21989 44255-44256 -LRB- denotes (
T21990 44256-44257 FW denotes i
T21991 44257-44258 -RRB- denotes )
T21992 44259-44268 VBD denotes sustained
T21993 44269-44274 JJ denotes NF-κB
T21994 44275-44283 NN denotes activity
T21995 44284-44286 IN denotes by
T21996 44287-44290 NNP denotes Tat
T21997 44291-44293 IN denotes in
T21998 44294-44302 NN denotes presence
T21999 44303-44305 IN denotes of
T22000 44306-44311 RB denotes newly
T22001 44312-44323 VBN denotes synthesized
T22002 44324-44329 NNP denotes IκB-α
T22003 44329-44330 : denotes ;
T22004 44331-44332 -LRB- denotes (
T22005 44332-44334 FW denotes ii
T22006 44334-44335 -RRB- denotes )
T22007 44336-44357 NN denotes coimmunoprecipitation
T22008 44358-44360 IN denotes of
T22009 44361-44364 NNP denotes Tat
T22010 44365-44369 IN denotes with
T22011 44370-44375 NNP denotes IκB-α
T22012 44376-44379 CC denotes and
T22013 44380-44383 CD denotes p65
T22014 44383-44384 : denotes ;
T22015 44385-44386 -LRB- denotes (
T22016 44386-44389 FW denotes iii
T22017 44389-44390 -RRB- denotes )
T22018 44391-44400 NN denotes induction
T22019 44401-44403 IN denotes of
T22020 44404-44410 JJ denotes MIP-1α
T22021 44411-44421 NN denotes expression
T22022 44422-44431 JJ denotes dependent
T22023 44432-44434 IN denotes on
T22024 44435-44438 NNP denotes Tat
T22025 44439-44442 CC denotes and
T22026 44443-44446 CD denotes p65
T22027 44446-44447 : denotes ;
T22028 44448-44449 -LRB- denotes (
T22029 44449-44451 NN denotes iv
T22030 44451-44452 -RRB- denotes )
T22031 44453-44456 NN denotes Tat
T22032 44457-44466 NN denotes occupancy
T22033 44467-44469 IN denotes of
T22034 44470-44473 DT denotes the
T22035 44474-44480 NNP denotes MIP-1α
T22036 44481-44486 NNP denotes NF-κB
T22037 44487-44495 NN denotes enhancer
T22038 44496-44506 VBN denotes associated
T22039 44507-44511 IN denotes with
T22040 44512-44521 VBN denotes increased
T22041 44522-44533 NN denotes recruitment
T22042 44534-44536 IN denotes of
T22043 44537-44540 NNS denotes p65
T22044 44540-44541 . denotes .
T22045 44542-44546 DT denotes This
T22046 44547-44552 NN denotes study
T22047 44553-44561 VBZ denotes supports
T22048 44562-44565 DT denotes the
T22049 44566-44582 JJ denotes pro-inflammatory
T22050 44583-44589 NN denotes action
T22051 44590-44592 IN denotes of
T22052 44593-44596 NNP denotes Tat
T22053 44597-44604 IN denotes through
T22054 44605-44613 JJ denotes physical
T22055 44614-44625 NN denotes interaction
T22056 44626-44630 IN denotes with
T22057 44631-44634 CD denotes p65
T22058 44635-44638 CC denotes and
T22059 44639-44644 NNP denotes IκB-α
T22060 44644-44645 . denotes .
T22061 44646-44653 JJ denotes Several
T22062 44654-44666 JJ denotes inflammatory
T22063 44667-44676 NNS denotes cytokines
T22064 44677-44682 IN denotes under
T22065 44683-44686 DT denotes the
T22066 44687-44702 JJ denotes transcriptional
T22067 44703-44710 NN denotes control
T22068 44711-44713 IN denotes of
T22069 44714-44719 NNP denotes NF-κB
T22070 44720-44723 VBP denotes are
T22071 44724-44739 JJ denotes hyper-expressed
T22072 44740-44742 IN denotes in
T22073 44743-44748 JJ denotes HIV-1
T22074 44749-44757 JJ denotes infected
T22075 44758-44769 NNS denotes individuals
T22076 44769-44770 , denotes ,
T22077 44771-44780 VBG denotes including
T22078 44781-44785 NNP denotes IL-6
T22079 44786-44787 -LRB- denotes (
T22080 44787-44792 CD denotes 66,67
T22081 44792-44793 -RRB- denotes )
T22082 44793-44794 , denotes ,
T22083 44795-44800 NNP denotes TNF-α
T22084 44801-44802 -LRB- denotes (
T22085 44802-44804 CD denotes 68
T22086 44804-44805 -RRB- denotes )
T22087 44805-44806 , denotes ,
T22088 44807-44810 CC denotes and
T22089 44811-44817 NNP denotes MIP-1α
T22090 44818-44819 -LRB- denotes (
T22091 44819-44821 CD denotes 57
T22092 44822-44827 CD denotes 62,69
T22093 44828-44830 CD denotes 71
T22094 44830-44831 -RRB- denotes )
T22095 44831-44832 . denotes .
T22096 44833-44835 IN denotes In
T22097 44836-44839 DT denotes the
T22098 44840-44844 NN denotes case
T22099 44845-44847 IN denotes of
T22100 44848-44853 NNP denotes TNF-α
T22101 44854-44857 CC denotes and
T22102 44858-44862 NNP denotes IL-6
T22103 44862-44863 , denotes ,
T22104 44864-44867 NNP denotes Tat
T22105 44868-44877 VBD denotes activated
T22106 44878-44881 DT denotes the
T22107 44882-44890 NN denotes cytokine
T22108 44891-44901 NN denotes expression
T22109 44902-44904 IN denotes by
T22110 44905-44912 JJ denotes binding
T22111 44913-44915 TO denotes to
T22112 44916-44919 DT denotes the
T22113 44920-44928 JJ denotes TAR-like
T22114 44929-44933 NN denotes stem
T22115 44934-44938 NN denotes loop
T22116 44939-44941 IN denotes of
T22117 44942-44945 DT denotes the
T22118 44946-44947 CD denotes 5
T22119 44947-44948 NN denotes ′
T22120 44949-44959 NN denotes transcript
T22121 44959-44960 , denotes ,
T22122 44961-44965 RB denotes thus
T22123 44966-44972 JJ denotes likely
T22124 44973-44982 VBG denotes promoting
T22125 44983-44986 DT denotes the
T22126 44987-45002 JJ denotes transcriptional
T22127 45003-45013 NN denotes elongation
T22128 45014-45015 -LRB- denotes (
T22129 45015-45023 CD denotes 33,37,47
T22130 45023-45024 -RRB- denotes )
T22131 45024-45025 . denotes .
T22132 45026-45030 RB denotes Here
T22133 45030-45031 , denotes ,
T22134 45032-45034 PRP denotes we
T22135 45035-45039 VBP denotes have
T22136 45040-45045 VBN denotes shown
T22137 45046-45050 IN denotes that
T22138 45051-45054 DT denotes the
T22139 45055-45068 JJ denotes Tat-dependent
T22140 45069-45084 JJ denotes transcriptional
T22141 45085-45095 NN denotes activation
T22142 45096-45098 IN denotes of
T22143 45099-45100 DT denotes a
T22144 45101-45107 NN denotes number
T22145 45108-45110 IN denotes of
T22146 45111-45127 JJ denotes pro-inflammatory
T22147 45128-45133 NNS denotes genes
T22148 45134-45142 VBD denotes required
T22149 45143-45146 DT denotes the
T22150 45147-45155 NN denotes assembly
T22151 45156-45158 IN denotes of
T22152 45159-45162 NNP denotes Tat
T22153 45163-45167 IN denotes with
T22154 45168-45171 CD denotes p65
T22155 45172-45174 IN denotes at
T22156 45175-45178 DT denotes the
T22157 45179-45184 NNP denotes NF-κB
T22158 45185-45193 NN denotes enhancer
T22159 45194-45202 RB denotes together
T22160 45203-45207 IN denotes with
T22161 45208-45211 DT denotes the
T22162 45212-45224 NN denotes displacement
T22163 45225-45227 IN denotes of
T22164 45228-45233 NNP denotes IκB-α
T22165 45234-45235 -LRB- denotes (
T22166 45235-45241 NNP denotes Figure
T22167 45242-45243 CD denotes 5
T22168 45243-45244 -RRB- denotes )
T22169 45244-45245 . denotes .
T22170 45246-45250 RB denotes Thus
T22171 45250-45251 , denotes ,
T22172 45252-45254 IN denotes in
T22173 45255-45258 DT denotes the
T22174 45259-45262 NN denotes set
T22175 45263-45265 IN denotes of
T22176 45266-45274 JJ denotes distinct
T22177 45275-45291 JJ denotes NF-κB-responsive
T22178 45292-45297 NNS denotes genes
T22179 45297-45298 , denotes ,
T22180 45299-45302 NNP denotes Tat
T22181 45303-45308 VBD denotes acted
T22182 45309-45311 IN denotes as
T22183 45312-45313 DT denotes a
T22184 45314-45323 NN denotes component
T22185 45324-45326 IN denotes of
T22186 45327-45330 DT denotes the
T22187 45331-45346 JJ denotes transcriptional
T22188 45347-45357 NN denotes initiation
T22189 45358-45365 NN denotes complex
T22190 45365-45366 , denotes ,
T22191 45367-45372 WDT denotes which
T22192 45373-45375 VBZ denotes is
T22193 45376-45386 JJ denotes consistent
T22194 45387-45391 IN denotes with
T22195 45392-45400 JJ denotes previous
T22196 45401-45408 NNS denotes reports
T22197 45409-45411 IN denotes on
T22198 45412-45415 NNP denotes Tat
T22199 45416-45425 VBG denotes promoting
T22200 45426-45429 DT denotes the
T22201 45430-45443 NN denotes transcription
T22202 45444-45447 IN denotes via
T22203 45448-45451 NNP denotes DNA
T22204 45452-45458 NNS denotes motifs
T22205 45459-45460 -LRB- denotes (
T22206 45460-45465 CD denotes 72,73
T22207 45465-45466 -RRB- denotes )
T22208 45466-45467 . denotes .
T22209 45468-45482 NN denotes Overproduction
T22210 45483-45485 IN denotes of
T22211 45486-45502 JJ denotes pro-inflammatory
T22212 45503-45512 NNS denotes cytokines
T22213 45513-45515 VBZ denotes is
T22214 45516-45526 VBN denotes considered
T22215 45527-45528 DT denotes a
T22216 45529-45534 JJ denotes major
T22217 45535-45544 NN denotes mechanism
T22218 45545-45547 IN denotes of
T22219 45548-45554 JJ denotes immune
T22220 45555-45567 NN denotes deregulation
T22221 45568-45569 -LRB- denotes (
T22222 45569-45571 CD denotes 26
T22223 45571-45572 -RRB- denotes )
T22224 45573-45576 CC denotes and
T22225 45577-45583 NN denotes neuron
T22226 45584-45595 NN denotes dysfunction
T22227 45596-45598 IN denotes in
T22228 45599-45603 NNP denotes AIDS
T22229 45604-45605 -LRB- denotes (
T22230 45605-45610 CD denotes 74,75
T22231 45610-45611 -RRB- denotes )
T22232 45611-45612 . denotes .
T22233 45613-45615 IN denotes In
T22234 45616-45620 DT denotes this
T22235 45621-45629 NN denotes scenario
T22236 45629-45630 , denotes ,
T22237 45631-45641 NN denotes inhibition
T22238 45642-45644 IN denotes of
T22239 45645-45650 JJ denotes NF-κB
T22240 45651-45659 NN denotes activity
T22241 45660-45665 MD denotes could
T22242 45666-45670 VB denotes lead
T22243 45671-45673 TO denotes to
T22244 45674-45675 DT denotes a
T22245 45676-45687 JJ denotes therapeutic
T22246 45688-45696 NN denotes strategy
T22247 45697-45700 IN denotes for
T22248 45701-45714 VBG denotes counteracting
T22249 45715-45718 DT denotes the
T22250 45719-45727 JJ denotes abnormal
T22251 45728-45738 NN denotes production
T22252 45739-45741 IN denotes of
T22253 45742-45758 JJ denotes pro-inflammatory
T22254 45759-45768 NNS denotes cytokines
T22255 45769-45772 CC denotes and
T22256 45773-45783 NNS denotes chemokines
T22257 45784-45786 IN denotes in
T22258 45787-45792 JJ denotes HIV-1
T22259 45793-45802 NN denotes infection
T22260 45802-45803 . denotes .
T22261 45804-45809 JJ denotes NF-κB
T22262 45810-45820 NNS denotes inhibitors
T22263 45820-45821 , denotes ,
T22264 45822-45826 JJ denotes such
T22265 45827-45829 IN denotes as
T22266 45830-45843 NNS denotes anti-oxidants
T22267 45843-45844 , denotes ,
T22268 45845-45855 JJ denotes proteasome
T22269 45856-45859 CC denotes and
T22270 45860-45863 NNP denotes IKK
T22271 45864-45874 NNS denotes inhibitors
T22272 45874-45875 , denotes ,
T22273 45876-45889 RB denotes significantly
T22274 45890-45897 VBD denotes reduced
T22275 45898-45901 DT denotes the
T22276 45902-45907 NNP denotes HIV-1
T22277 45908-45919 NN denotes replication
T22278 45920-45923 CC denotes and
T22279 45924-45927 DT denotes the
T22280 45928-45938 VBN denotes associated
T22281 45939-45951 JJ denotes inflammatory
T22282 45952-45960 NN denotes response
T22283 45961-45962 -LRB- denotes (
T22284 45962-45967 CD denotes 76,77
T22285 45967-45968 -RRB- denotes )
T22286 45968-45969 : denotes ;
T22287 45970-45977 RB denotes however
T22288 45977-45978 , denotes ,
T22289 45979-45984 DT denotes these
T22290 45985-45990 JJ denotes NF-κB
T22291 45991-46001 NNS denotes inhibitors
T22292 46002-46007 VBD denotes acted
T22293 46008-46024 RB denotes indiscriminately
T22294 46025-46027 IN denotes in
T22295 46028-46032 DT denotes both
T22296 46033-46047 JJ denotes HIV-1-infected
T22297 46048-46051 CC denotes and
T22298 46052-46062 JJ denotes uninfected
T22299 46063-46068 NNS denotes cells
T22300 46068-46069 . denotes .
T22301 46070-46073 DT denotes The
T22302 46074-46082 NN denotes evidence
T22303 46083-46087 IN denotes that
T22304 46088-46091 NNP denotes Tat
T22305 46092-46101 VBZ denotes activates
T22306 46102-46107 NN denotes NF-κB
T22307 46108-46115 IN denotes through
T22308 46116-46122 JJ denotes direct
T22309 46123-46134 NN denotes interaction
T22310 46135-46139 IN denotes with
T22311 46140-46145 NNP denotes IκB-α
T22312 46146-46149 CC denotes and
T22313 46150-46153 NNS denotes p65
T22314 46154-46157 MD denotes may
T22315 46158-46162 VB denotes lead
T22316 46163-46165 TO denotes to
T22317 46166-46174 JJ denotes specific
T22318 46175-46185 NNS denotes inhibitors
T22319 46186-46188 TO denotes to
T22320 46189-46199 VB denotes counteract
T22321 46200-46203 DT denotes the
T22322 46204-46207 NNP denotes Tat
T22323 46208-46224 JJ denotes pro-inflammatory
T22324 46225-46231 NN denotes action
T22325 46231-46232 . denotes .
T23945 16062-16065 NNP denotes Tat
T23946 16066-16077 VBZ denotes counteracts
T23947 16078-16081 DT denotes the
T23948 16082-16097 JJ denotes post-activation
T23949 16098-16102 NN denotes turn
T23950 16103-16106 IN denotes off
T23951 16107-16109 IN denotes of
T23952 16110-16115 NN denotes NF-κB
T23953 16116-16118 IN denotes in
T23954 16119-16125 JJ denotes single
T23955 16126-16131 NN denotes round
T23956 16132-16147 NN denotes HIV-1-infection
T23957 16147-16148 . denotes .
T23958 16149-16155 NNP denotes Jurkat
T23959 16156-16161 NNS denotes cells
T23960 16162-16163 -LRB- denotes (
T23961 16163-16164 CD denotes 5
T23962 16165-16166 RB denotes ×
T23963 16167-16170 CD denotes 107
T23964 16170-16171 -RRB- denotes )
T23965 16172-16176 VBD denotes were
T23966 16177-16188 VBN denotes transfected
T23967 16189-16193 IN denotes with
T23968 16194-16199 NNP denotes siRNA
T23969 16200-16203 NNP denotes Tat
T23970 16204-16206 CC denotes or
T23971 16207-16212 NNP denotes siRNA
T23972 16213-16220 NN denotes control
T23973 16221-16222 -LRB- denotes (
T23974 16222-16223 CD denotes 2
T23975 16224-16228 NN denotes nmol
T23976 16228-16229 -RRB- denotes )
T23977 16229-16230 , denotes ,
T23978 16231-16233 CC denotes or
T23979 16234-16238 VBD denotes left
T23980 16239-16252 JJ denotes untransfected
T23981 16252-16253 : denotes ;
T23982 16254-16256 CD denotes 24
T23983 16257-16258 NN denotes h
T23984 16259-16264 RB denotes later
T23985 16264-16265 , denotes ,
T23986 16266-16271 NNS denotes cells
T23987 16272-16276 VBD denotes were
T23988 16277-16285 VBN denotes infected
T23989 16286-16290 IN denotes with
T23990 16291-16307 JJ denotes HXB2-pseudotyped
T23991 16308-16313 NN denotes NL4-3
T23992 16313-16314 . denotes .
T23993 16314-16319 NNP denotes Luc.R
T23994 16319-16320 NNP denotes −
T23995 16320-16321 NNP denotes E
T23996 16321-16322 VBD denotes −
T23997 16323-16330 NNS denotes virions
T23998 16331-16332 -LRB- denotes (
T23999 16332-16335 CD denotes 500
T24000 16336-16338 NN denotes ng
T24001 16339-16341 IN denotes of
T24002 16342-16345 CD denotes p24
T24003 16345-16346 -RRB- denotes )
T24004 16347-16350 CC denotes and
T24005 16351-16360 VBD denotes harvested
T24006 16361-16363 IN denotes at
T24007 16364-16367 DT denotes the
T24008 16368-16377 JJ denotes indicated
T24009 16378-16382 NN denotes time
T24010 16382-16383 . denotes .
T24011 16384-16385 -LRB- denotes (
T24012 16385-16386 NNP denotes A
T24013 16386-16387 -RRB- denotes )
T24014 16388-16391 NNP denotes Tat
T24015 16392-16402 NN denotes expression
T24016 16403-16406 VBD denotes was
T24017 16407-16415 VBN denotes measured
T24018 16416-16418 IN denotes in
T24019 16419-16424 JJ denotes total
T24020 16425-16428 NNP denotes RNA
T24021 16429-16431 IN denotes by
T24022 16432-16441 JJ denotes real-time
T24023 16442-16445 NNP denotes PCR
T24024 16445-16446 , denotes ,
T24025 16447-16452 IN denotes while
T24026 16453-16456 DT denotes the
T24027 16457-16467 NN denotes luciferase
T24028 16468-16476 NN denotes activity
T24029 16477-16480 VBD denotes was
T24030 16481-16489 VBN denotes measured
T24031 16490-16492 IN denotes in
T24032 16493-16498 JJ denotes whole
T24033 16499-16503 NN denotes cell
T24034 16504-16512 NNS denotes extracts
T24035 16512-16513 . denotes .
T24036 16514-16515 -LRB- denotes (
T24037 16515-16516 NNP denotes B
T24038 16516-16517 -RRB- denotes )
T24039 16518-16525 NNP denotes Nuclear
T24040 16526-16534 NNS denotes extracts
T24041 16535-16536 -LRB- denotes (
T24042 16536-16538 CD denotes 10
T24043 16539-16541 NN denotes µg
T24044 16541-16542 -RRB- denotes )
T24045 16543-16547 VBD denotes were
T24046 16548-16556 VBN denotes analysed
T24047 16557-16560 IN denotes for
T24048 16561-16564 DT denotes the
T24049 16565-16568 NNS denotes p65
T24050 16569-16572 CC denotes and
T24051 16573-16576 JJ denotes p50
T24052 16577-16584 JJ denotes binding
T24053 16585-16587 TO denotes to
T24054 16588-16591 DT denotes the
T24055 16592-16597 NNP denotes NF-κB
T24056 16598-16613 JJ denotes double-stranded
T24057 16614-16629 NN denotes oligonucleotide
T24058 16630-16635 VBG denotes using
T24059 16636-16639 DT denotes the
T24060 16640-16645 NNP denotes NF-κB
T24061 16646-16659 NNP denotes Transcription
T24062 16660-16666 NNP denotes Factor
T24063 16667-16672 NNP denotes ELISA
T24064 16673-16678 NNP denotes Assay
T24065 16679-16682 NN denotes kit
T24066 16683-16684 -LRB- denotes (
T24067 16684-16690 NNP denotes Cayman
T24068 16690-16691 -RRB- denotes )
T24069 16691-16692 . denotes .
T24070 16693-16694 -LRB- denotes (
T24071 16694-16695 $ denotes C
T24072 16695-16696 -RRB- denotes )
T24073 16697-16700 DT denotes The
T24074 16701-16711 NN denotes expression
T24075 16712-16714 IN denotes of
T24076 16715-16718 CD denotes p65
T24077 16719-16722 CC denotes and
T24078 16723-16728 NNP denotes IκB-α
T24079 16729-16732 VBD denotes was
T24080 16733-16741 VBN denotes analysed
T24081 16742-16744 IN denotes by
T24082 16745-16747 CD denotes 12
T24083 16747-16748 NN denotes %
T24084 16749-16752 NNP denotes SDS
T24085 16753-16757 NNP denotes PAGE
T24086 16758-16761 CC denotes and
T24087 16762-16769 JJ denotes western
T24088 16770-16778 VBG denotes blotting
T24089 16779-16781 IN denotes of
T24090 16782-16789 JJ denotes nuclear
T24091 16790-16792 CC denotes or
T24092 16793-16802 JJ denotes cytosolic
T24093 16803-16811 NNS denotes extracts
T24094 16812-16813 -LRB- denotes (
T24095 16813-16815 CD denotes 20
T24096 16816-16818 NN denotes µg
T24097 16818-16819 -RRB- denotes )
T24098 16820-16825 VBG denotes using
T24099 16826-16834 JJ denotes anti-p65
T24100 16835-16838 CC denotes and
T24101 16839-16849 JJ denotes anti-IκB-α
T24102 16850-16860 NNS denotes antibodies
T24103 16860-16861 . denotes .
T24104 16862-16869 NNP denotes Histone
T24105 16870-16872 NNP denotes H1
T24114 16930-16932 IN denotes as
T24115 16933-16940 NNS denotes markers
T24116 16941-16943 IN denotes of
T24117 16944-16951 JJ denotes nuclear
T24118 16952-16955 CC denotes and
T24119 16956-16965 JJ denotes cytosolic
T24120 16966-16974 NNS denotes extracts
T24121 16974-16975 , denotes ,
T24122 16976-16988 RB denotes respectively
T24123 16988-16989 . denotes .
T24124 16990-17002 NNP denotes Densitometry
T24125 17003-17009 NNS denotes values
T24126 17010-17011 -LRB- denotes (
T24127 17011-17012 NNP denotes D
T24128 17012-17013 -RRB- denotes )
T24129 17014-17016 IN denotes of
T24130 17017-17020 DT denotes the
T24131 17021-17026 NNS denotes bands
T24132 17027-17031 VBD denotes were
T24133 17032-17041 VBN denotes expressed
T24134 17042-17044 IN denotes as
T24135 17045-17049 VBP denotes fold
T24136 17050-17058 NN denotes increase
T24137 17059-17064 IN denotes above
T24138 17065-17068 DT denotes the
T24139 17069-17076 NN denotes control
T24140 17077-17078 -LRB- denotes (
T24141 17078-17082 JJ denotes mock
T24142 17082-17083 -RRB- denotes )
T24143 17083-17084 . denotes .
T24144 17085-17086 -LRB- denotes (
T24145 17086-17087 NNP denotes D
T24146 17087-17088 -RRB- denotes )
T24147 17089-17092 NNP denotes IKK
T24148 17093-17101 NN denotes activity
T24149 17102-17105 VBD denotes was
T24150 17106-17114 VBN denotes measured
T24151 17115-17117 IN denotes in
T24152 17118-17127 JJ denotes cytosolic
T24153 17128-17136 NNS denotes extracts
T24154 17137-17138 -LRB- denotes (
T24155 17138-17141 CD denotes 100
T24156 17142-17144 NN denotes µg
T24157 17144-17145 -RRB- denotes )
T24158 17146-17148 IN denotes by
T24159 17149-17154 VBG denotes using
T24160 17155-17161 NNP denotes HTScan
T24161 17162-17165 NNP denotes IKK
T24162 17166-17172 NNP denotes Kinase
T24163 17173-17178 NNP denotes Assay
T24164 17179-17180 -LRB- denotes (
T24165 17180-17184 NNP denotes Cell
T24166 17185-17194 NNP denotes Signaling
T24167 17195-17205 NNP denotes Technology
T24168 17205-17206 -RRB- denotes )
T24169 17206-17207 . denotes .
T24170 17208-17214 NNS denotes Values
T24171 17215-17216 -LRB- denotes (
T24172 17216-17220 JJ denotes mean
T24173 17221-17222 NN denotes ±
T24174 17223-17225 NNP denotes SE
T24175 17225-17226 , denotes ,
T24176 17227-17228 JJ denotes n
T24177 17229-17230 SYM denotes =
T24178 17231-17232 LS denotes 3
T24179 17232-17233 -RRB- denotes )
T24180 17234-17237 VBP denotes are
T24181 17238-17243 VBN denotes shown
T24182 17243-17244 . denotes .
T24672 20207-20210 NNP denotes Tat
T24673 20211-20219 VBZ denotes enhances
T24674 20220-20223 DT denotes the
T24675 20224-20229 JJ denotes NF-κB
T24676 20230-20238 NN denotes activity
T24677 20239-20248 VBG denotes following
T24678 20249-20252 NNP denotes PMA
T24679 20253-20264 NN denotes stimulation
T24680 20265-20267 IN denotes by
T24681 20268-20279 VBG denotes associating
T24682 20280-20284 IN denotes with
T24683 20285-20290 NNP denotes IκB-α
T24684 20291-20294 CC denotes and
T24685 20295-20308 VBG denotes counteracting
T24686 20309-20312 DT denotes the
T24687 20313-20318 JJ denotes NF-κB
T24688 20319-20329 NN denotes repression
T24689 20329-20330 . denotes .
T24690 20331-20335 NNP denotes HeLa
T24691 20336-20341 NNS denotes cells
T24692 20342-20343 -LRB- denotes (
T24693 20343-20344 CD denotes 5
T24694 20345-20346 CD denotes ×
T24695 20347-20350 CD denotes 106
T24696 20350-20351 -RRB- denotes )
T24697 20352-20356 VBD denotes were
T24698 20357-20368 VBN denotes transfected
T24699 20369-20373 IN denotes with
T24700 20374-20385 NN denotes p3xFLAG-Tat
T24701 20386-20388 CC denotes or
T24702 20389-20396 JJ denotes p3xFLAG
T24703 20397-20402 JJ denotes empty
T24704 20403-20409 NN denotes vector
T24705 20410-20411 -LRB- denotes (
T24706 20411-20412 CD denotes 5
T24707 20413-20415 NN denotes µg
T24708 20415-20416 -RRB- denotes )
T24709 20416-20417 , denotes ,
T24710 20418-20421 CC denotes and
T24711 20422-20424 CD denotes 48
T24712 20425-20426 NN denotes h
T24713 20427-20432 RB denotes later
T24714 20433-20437 VBD denotes were
T24715 20438-20448 VBN denotes stimulated
T24716 20449-20453 IN denotes with
T24717 20454-20457 NNP denotes PMA
T24718 20458-20459 -LRB- denotes (
T24719 20459-20460 CD denotes 5
T24720 20461-20464 NN denotes min
T24721 20464-20465 , denotes ,
T24722 20466-20468 CD denotes 20
T24723 20469-20474 NN denotes ng/ml
T24724 20474-20475 -RRB- denotes )
T24725 20476-20478 CC denotes or
T24726 20479-20483 VBD denotes left
T24727 20484-20496 JJ denotes unstimulated
T24728 20496-20497 , denotes ,
T24729 20498-20504 VBD denotes washed
T24730 20505-20510 RB denotes twice
T24731 20511-20515 IN denotes with
T24732 20516-20520 NNP denotes DMEM
T24733 20521-20524 CC denotes and
T24734 20525-20534 VBN denotes harvested
T24735 20535-20537 IN denotes at
T24736 20538-20541 DT denotes the
T24737 20542-20551 JJ denotes indicated
T24738 20552-20557 NNS denotes times
T24739 20557-20558 . denotes .
T24740 20559-20566 NNP denotes Nuclear
T24741 20567-20570 CC denotes and
T24742 20571-20580 JJ denotes cytosolic
T24743 20581-20589 NNS denotes extracts
T24744 20590-20594 VBD denotes were
T24745 20595-20603 VBN denotes prepared
T24746 20604-20607 IN denotes for
T24747 20608-20615 JJ denotes further
T24748 20616-20624 NN denotes analysis
T24749 20624-20625 . denotes .
T24750 20626-20627 -LRB- denotes (
T24751 20627-20628 NNP denotes A
T24752 20628-20629 -RRB- denotes )
T24753 20630-20637 NNP denotes Nuclear
T24754 20638-20646 NNS denotes extracts
T24755 20647-20651 VBD denotes were
T24756 20652-20660 VBN denotes analysed
T24757 20661-20664 IN denotes for
T24758 20665-20668 DT denotes the
T24759 20669-20672 NNS denotes p65
T24760 20672-20673 , denotes ,
T24761 20674-20677 JJ denotes p50
T24762 20678-20681 CC denotes and
T24763 20682-20690 JJ denotes FLAG-Tat
T24764 20691-20698 JJ denotes binding
T24765 20699-20701 TO denotes to
T24766 20702-20705 DT denotes the
T24767 20706-20711 NNP denotes NF-κB
T24768 20712-20727 JJ denotes double-stranded
T24769 20728-20743 NN denotes oligonucleotide
T24770 20744-20749 VBG denotes using
T24771 20750-20753 DT denotes the
T24772 20754-20759 NNP denotes NF-κB
T24773 20760-20773 NNP denotes Transcription
T24774 20774-20780 NNP denotes Factor
T24775 20781-20786 NNP denotes ELISA
T24776 20787-20792 NN denotes assay
T24777 20793-20796 NN denotes kit
T24778 20797-20798 -LRB- denotes (
T24779 20798-20804 NNP denotes Cayman
T24780 20804-20805 -RRB- denotes )
T24781 20805-20806 . denotes .
T24782 20807-20808 -LRB- denotes (
T24783 20808-20809 NNP denotes B
T24784 20809-20810 -RRB- denotes )
T24785 20811-20818 NNP denotes Nuclear
T24786 20819-20822 CC denotes and
T24787 20823-20832 JJ denotes cytosolic
T24788 20833-20841 NNS denotes extracts
T24789 20842-20843 -LRB- denotes (
T24790 20843-20845 CD denotes 20
T24791 20846-20848 NN denotes µg
T24792 20848-20849 -RRB- denotes )
T24793 20850-20854 VBD denotes were
T24794 20855-20864 VBN denotes separated
T24795 20865-20867 IN denotes by
T24796 20868-20870 CD denotes 12
T24797 20870-20871 NN denotes %
T24798 20872-20875 NNP denotes SDS
T24799 20876-20880 NNP denotes PAGE
T24800 20881-20884 CC denotes and
T24801 20885-20893 VBN denotes analysed
T24802 20894-20896 IN denotes by
T24803 20897-20904 JJ denotes western
T24804 20905-20913 VBG denotes blotting
T24805 20914-20919 VBG denotes using
T24806 20920-20923 DT denotes the
T24807 20924-20932 JJ denotes anti-p65
T24808 20932-20933 , denotes ,
T24809 20934-20943 JJ denotes anti-FLAG
T24810 20943-20944 , denotes ,
T24811 20945-20957 JJ denotes anti-Histone
T24812 20958-20960 NN denotes H1
T24813 20960-20961 , denotes ,
T24814 20962-20972 JJ denotes anti-IκB-α
T24815 20973-20976 CC denotes and
T24816 20977-20995 JJ denotes anti-Hexokinase-II
T24817 20996-21006 NNS denotes antibodies
T24818 21006-21007 . denotes .
T24819 21008-21020 NNP denotes Densitometry
T24820 21021-21027 NNS denotes values
T24821 21028-21029 -LRB- denotes (
T24822 21029-21030 NNP denotes D
T24823 21030-21031 -RRB- denotes )
T24824 21032-21034 IN denotes of
T24825 21035-21038 DT denotes the
T24826 21039-21044 NNS denotes bands
T24827 21045-21049 VBD denotes were
T24828 21050-21059 VBN denotes expressed
T24829 21060-21062 IN denotes as
T24830 21063-21067 VBP denotes fold
T24831 21068-21076 NN denotes increase
T24832 21077-21082 IN denotes above
T24833 21083-21086 DT denotes the
T24834 21087-21094 NN denotes control
T24835 21095-21096 -LRB- denotes (
T24836 21096-21100 NN denotes lane
T24837 21101-21102 CD denotes 1
T24838 21102-21103 -RRB- denotes )
T24839 21103-21104 . denotes .
T24840 21105-21106 -LRB- denotes (
T24841 21106-21107 NNP denotes C
T24842 21107-21108 -RRB- denotes )
T24843 21109-21112 NNP denotes IKK
T24844 21113-21121 NN denotes activity
T24845 21122-21125 VBD denotes was
T24846 21126-21134 VBN denotes measured
T24847 21135-21137 IN denotes in
T24848 21138-21147 JJ denotes cytosolic
T24849 21148-21156 NNS denotes extracts
T24850 21157-21158 -LRB- denotes (
T24851 21158-21161 CD denotes 100
T24852 21162-21164 NN denotes µg
T24853 21164-21165 -RRB- denotes )
T24854 21166-21168 IN denotes by
T24855 21169-21174 VBG denotes using
T24856 21175-21181 NNP denotes HTScan
T24857 21182-21185 NNP denotes IKK
T24858 21186-21192 NN denotes kinase
T24859 21193-21198 NN denotes assay
T24860 21199-21200 -LRB- denotes (
T24861 21200-21204 NNP denotes Cell
T24862 21205-21214 NNP denotes Signaling
T24863 21215-21225 NNP denotes Technology
T24864 21225-21226 -RRB- denotes )
T24865 21226-21227 . denotes .
T24866 21228-21229 -LRB- denotes (
T24867 21229-21230 NNP denotes D
T24868 21230-21231 -RRB- denotes )
T24869 21232-21236 NNP denotes HeLa
T24870 21237-21242 NNS denotes cells
T24871 21243-21244 -LRB- denotes (
T24872 21244-21245 CD denotes 5
T24873 21246-21247 CD denotes ×
T24874 21248-21251 CD denotes 106
T24875 21251-21252 -RRB- denotes )
T24876 21253-21257 VBD denotes were
T24877 21258-21269 VBN denotes transfected
T24878 21270-21274 IN denotes with
T24879 21275-21277 CC denotes or
T24880 21278-21285 IN denotes without
T24881 21286-21297 NN denotes p3xFLAG-Tat
T24882 21298-21299 -LRB- denotes (
T24883 21299-21300 CD denotes 5
T24884 21301-21303 NN denotes µg
T24885 21303-21304 -RRB- denotes )
T24886 21304-21305 : denotes ;
T24887 21306-21308 CD denotes 48
T24888 21309-21310 NN denotes h
T24889 21311-21316 RB denotes later
T24890 21316-21317 , denotes ,
T24891 21318-21323 NNS denotes cells
T24892 21324-21328 VBD denotes were
T24893 21329-21339 VBN denotes stimulated
T24894 21340-21344 IN denotes with
T24895 21345-21348 NNP denotes PMA
T24896 21349-21350 -LRB- denotes (
T24897 21350-21351 CD denotes 5
T24898 21352-21355 NN denotes min
T24899 21355-21356 , denotes ,
T24900 21357-21359 CD denotes 20
T24901 21360-21365 NN denotes ng/ml
T24902 21365-21366 -RRB- denotes )
T24903 21367-21369 CC denotes or
T24904 21370-21374 VBD denotes left
T24905 21375-21387 JJ denotes unstimulated
T24906 21387-21388 , denotes ,
T24907 21389-21395 VBD denotes washed
T24908 21396-21401 RB denotes twice
T24909 21402-21406 IN denotes with
T24910 21407-21411 NNP denotes DMEM
T24911 21411-21412 , denotes ,
T24912 21413-21416 CC denotes and
T24913 21417-21426 VBN denotes harvested
T24914 21427-21432 IN denotes after
T24915 21433-21436 CD denotes 240
T24916 21437-21440 NN denotes min
T24917 21440-21441 . denotes .
T24918 21442-21447 JJ denotes Whole
T24919 21448-21452 NN denotes cell
T24920 21453-21461 NNS denotes extracts
T24921 21462-21463 -LRB- denotes (
T24922 21463-21464 CD denotes 1
T24923 21465-21467 NN denotes mg
T24924 21467-21468 -RRB- denotes )
T24925 21469-21473 VBD denotes were
T24926 21474-21492 VBN denotes immunoprecipitated
T24927 21493-21497 IN denotes with
T24928 21498-21505 NN denotes protein
T24929 21506-21525 JJ denotes G-Sepharose-coupled
T24930 21526-21536 JJ denotes anti-IκB-α
T24931 21537-21545 NN denotes antibody
T24932 21545-21546 . denotes .
T24933 21547-21562 NNS denotes Immunocomplexes
T24934 21563-21567 VBD denotes were
T24935 21568-21577 VBN denotes separated
T24936 21578-21580 IN denotes by
T24937 21581-21583 CD denotes 12
T24938 21583-21584 NN denotes %
T24939 21585-21588 NNP denotes SDS
T24940 21589-21593 NNP denotes PAGE
T24941 21594-21597 CC denotes and
T24942 21598-21606 VBN denotes analysed
T24943 21607-21609 IN denotes by
T24944 21610-21617 JJ denotes western
T24945 21618-21626 VBG denotes blotting
T24946 21627-21631 IN denotes with
T24947 21632-21640 JJ denotes anti-p65
T24948 21640-21641 , denotes ,
T24949 21642-21651 JJ denotes anti-FLAG
T24950 21652-21655 CC denotes and
T24951 21656-21666 JJ denotes anti-IκB-α
T24952 21667-21677 NNS denotes antibodies
T24953 21677-21678 . denotes .
T24954 21679-21691 NNP denotes Densitometry
T24955 21692-21698 NNS denotes values
T24956 21699-21700 -LRB- denotes (
T24957 21700-21701 NNP denotes D
T24958 21701-21702 -RRB- denotes )
T24959 21703-21705 IN denotes of
T24960 21706-21709 DT denotes the
T24961 21710-21715 NNS denotes bands
T24962 21716-21720 VBD denotes were
T24963 21721-21730 VBN denotes expressed
T24964 21731-21733 IN denotes as
T24965 21734-21738 VBP denotes fold
T24966 21739-21747 NN denotes increase
T24967 21748-21753 IN denotes above
T24968 21754-21757 DT denotes the
T24969 21758-21765 NN denotes control
T24970 21766-21767 -LRB- denotes (
T24971 21767-21771 NN denotes lane
T24972 21772-21773 CD denotes 1
T24973 21773-21774 -RRB- denotes )
T24974 21774-21775 . denotes .
T24975 21776-21782 NNS denotes Values
T24976 21783-21784 -LRB- denotes (
T24977 21784-21788 JJ denotes mean
T24978 21789-21790 NN denotes ±
T24979 21791-21793 NNP denotes SE
T24980 21793-21794 , denotes ,
T24981 21795-21796 JJ denotes n
T24982 21797-21798 SYM denotes =
T24983 21799-21800 LS denotes 3
T24984 21800-21801 -RRB- denotes )
T24985 21802-21805 VBP denotes are
T24986 21806-21811 VBN denotes shown
T24987 21811-21812 . denotes .
T25677 23400-23403 NNP denotes Tat
T25678 23404-23412 VBZ denotes relieves
T25679 23413-23416 CD denotes p65
T25680 23417-23421 IN denotes from
T25681 23422-23425 DT denotes the
T25682 23426-23431 JJ denotes IκB-α
T25683 23432-23442 NN denotes inhibition
T25684 23442-23443 . denotes .
T25685 23444-23445 -LRB- denotes (
T25686 23445-23446 NN denotes A
T25687 23446-23447 -RRB- denotes )
T25688 23448-23457 JJ denotes Schematic
T25689 23458-23472 NN denotes representation
T25690 23473-23475 IN denotes of
T25691 23476-23485 JJ denotes wild-type
T25692 23486-23489 CC denotes and
T25693 23490-23496 JJ denotes mutant
T25694 23497-23500 NNP denotes Tat
T25695 23501-23509 NNS denotes proteins
T25696 23509-23510 . denotes .
T25697 23511-23512 -LRB- denotes (
T25698 23512-23513 NNP denotes B
T25699 23513-23514 -RRB- denotes )
T25700 23515-23523 NNP denotes HA-IκB-α
T25701 23524-23525 -LRB- denotes (
T25702 23525-23526 CD denotes 5
T25703 23527-23529 NN denotes µl
T25704 23529-23530 -RRB- denotes )
T25705 23531-23534 VBD denotes was
T25706 23535-23544 VBN denotes incubated
T25707 23545-23547 IN denotes in
T25708 23548-23556 NN denotes presence
T25709 23557-23559 CC denotes or
T25710 23560-23567 NN denotes absence
T25711 23568-23570 IN denotes of
T25712 23571-23579 NNP denotes FLAG-Tat
T25713 23579-23580 , denotes ,
T25714 23581-23589 NNP denotes FLAG-Tat
T25715 23590-23591 NNP denotes T
T25716 23591-23592 , denotes ,
T25717 23792-23793 : denotes ;
T25718 23592-23593 NNP denotes N
T25719 23593-23594 -LRB- denotes (
T25720 23594-23599 CD denotes 23,24
T25721 23599-23600 -RRB- denotes )
T25722 23600-23601 DT denotes A
T25723 23601-23602 , denotes ,
T25724 23603-23611 JJ denotes FLAG-Tat
T25725 23612-23613 NNP denotes K
T25726 23613-23614 -LRB- denotes (
T25727 23614-23619 CD denotes 50,51
T25728 23619-23620 -RRB- denotes )
T25729 23620-23621 DT denotes A
T25730 23621-23622 , denotes ,
T25731 23623-23631 JJ denotes FLAG-Tat
T25732 23632-23633 NN denotes R
T25733 23633-23634 -LRB- denotes (
T25734 23634-23636 CD denotes 49
T25735 23637-23639 CD denotes 57
T25736 23639-23640 -RRB- denotes )
T25737 23640-23641 DT denotes A
T25738 23642-23644 CC denotes or
T25739 23645-23653 JJ denotes FLAG-Tat
T25740 23654-23655 NNP denotes C
T25741 23655-23656 -LRB- denotes (
T25742 23656-23664 CD denotes 22,25,27
T25743 23664-23665 -RRB- denotes )
T25744 23665-23666 DT denotes A
T25745 23667-23668 -LRB- denotes (
T25746 23668-23670 CD denotes 10
T25747 23671-23673 NN denotes µl
T25748 23673-23674 -RRB- denotes )
T25749 23675-23680 VBG denotes using
T25750 23681-23683 IN denotes in
T25751 23684-23689 NN denotes vitro
T25752 23690-23700 VBN denotes translated
T25753 23701-23709 NNS denotes proteins
T25754 23709-23710 . denotes .
T25755 23711-23720 JJ denotes Wild-type
T25756 23721-23724 CC denotes and
T25757 23725-23731 JJ denotes mutant
T25758 23732-23735 NNP denotes Tat
T25759 23736-23744 NNS denotes proteins
T25760 23745-23749 VBD denotes were
T25761 23750-23768 VBN denotes immunoprecipitated
T25762 23769-23773 IN denotes with
T25763 23774-23783 JJ denotes anti-FLAG
T25764 23784-23792 NN denotes antibody
T25765 23794-23809 NNS denotes immunocomplexes
T25766 23810-23814 VBD denotes were
T25767 23815-23824 VBN denotes separated
T25768 23825-23827 IN denotes by
T25769 23828-23830 CD denotes 12
T25770 23830-23831 NN denotes %
T25771 23832-23835 NNP denotes SDS
T25772 23836-23840 NNP denotes PAGE
T25773 23841-23844 CC denotes and
T25774 23845-23853 VBN denotes analysed
T25775 23854-23856 IN denotes by
T25776 23857-23864 JJ denotes western
T25777 23865-23873 VBG denotes blotting
T25778 23874-23878 IN denotes with
T25779 23879-23886 JJ denotes anti-HA
T25780 23887-23890 CC denotes and
T25781 23891-23900 JJ denotes anti-FLAG
T25782 23901-23911 NNS denotes antibodies
T25783 23911-23912 . denotes .
T25784 23913-23914 -LRB- denotes (
T25785 23914-23915 $ denotes C
T25786 23915-23916 -RRB- denotes )
T25787 23917-23939 JJ denotes 35S-methionine-labeled
T25788 23940-23943 NNS denotes p65
T25789 23944-23945 -LRB- denotes (
T25790 23945-23946 CD denotes 5
T25791 23947-23949 NN denotes µl
T25792 23949-23950 -RRB- denotes )
T25793 23951-23954 VBD denotes was
T25794 23955-23964 VBN denotes incubated
T25795 23965-23969 IN denotes with
T25796 23970-23972 IN denotes in
T25797 23973-23978 NN denotes vitro
T25798 23979-23989 VBN denotes translated
T25799 23990-23998 NNP denotes HA-IκB-α
T25800 23999-24000 -LRB- denotes (
T25801 24000-24001 CD denotes 5
T25802 24002-24004 NN denotes µl
T25803 24004-24005 -RRB- denotes )
T25804 24006-24008 IN denotes in
T25805 24009-24017 NN denotes presence
T25806 24018-24020 CC denotes or
T25807 24021-24028 NN denotes absence
T25808 24029-24031 IN denotes of
T25809 24032-24040 NN denotes FLAG-Tat
T25810 24041-24043 CC denotes or
T25811 24044-24052 NN denotes FLAG-Tat
T25812 24053-24054 NN denotes R
T25813 24054-24055 -LRB- denotes (
T25814 24055-24057 CD denotes 49
T25815 24058-24060 CD denotes 57
T25816 24060-24061 -RRB- denotes )
T25817 24061-24062 DT denotes A
T25818 24063-24064 -LRB- denotes (
T25819 24064-24065 CD denotes 5
T25820 24065-24066 , denotes ,
T25821 24067-24069 CD denotes 10
T25822 24070-24072 CC denotes or
T25823 24073-24075 CD denotes 20
T25824 24076-24078 NN denotes µl
T25825 24078-24079 -RRB- denotes )
T25826 24079-24080 . denotes .
T25827 24081-24089 NNP denotes HA-IκB-α
T25828 24090-24093 VBD denotes was
T25829 24094-24112 VBN denotes immunoprecipitated
T25830 24113-24117 IN denotes with
T25831 24118-24125 JJ denotes anti-HA
T25832 24126-24134 NN denotes antibody
T25833 24134-24135 : denotes ;
T25834 24136-24151 NNS denotes immunocomplexes
T25835 24152-24156 VBD denotes were
T25836 24157-24166 VBN denotes separated
T25837 24167-24169 IN denotes by
T25838 24170-24172 CD denotes 12
T25839 24172-24173 NN denotes %
T25840 24174-24177 NNP denotes SDS
T25841 24178-24182 NNP denotes PAGE
T25842 24183-24186 CC denotes and
T25843 24187-24195 VBN denotes analysed
T25844 24196-24198 IN denotes by
T25845 24199-24206 JJ denotes western
T25846 24207-24215 VBG denotes blotting
T25847 24216-24220 IN denotes with
T25848 24221-24228 JJ denotes anti-HA
T25849 24229-24232 CC denotes and
T25850 24233-24242 JJ denotes anti-FLAG
T25851 24243-24253 NNS denotes antibodies
T25852 24253-24254 , denotes ,
T25853 24255-24257 CC denotes or
T25854 24258-24273 NN denotes autoradiography
T25855 24274-24275 -LRB- denotes (
T25856 24275-24286 NNP denotes 35S-Met-p65
T25857 24286-24287 -RRB- denotes )
T25858 24287-24288 . denotes .
T25859 24289-24301 NNP denotes Densitometry
T25860 24302-24308 NNS denotes values
T25861 24309-24310 -LRB- denotes (
T25862 24310-24311 NNP denotes D
T25863 24311-24312 -RRB- denotes )
T25864 24313-24315 IN denotes of
T25865 24316-24319 DT denotes the
T25866 24320-24325 NNS denotes bands
T25867 24326-24330 VBD denotes were
T25868 24331-24340 VBN denotes expressed
T25869 24341-24343 IN denotes as
T25870 24344-24348 VBP denotes fold
T25871 24349-24357 NN denotes increase
T25872 24358-24363 IN denotes above
T25873 24364-24367 DT denotes the
T25874 24368-24375 NN denotes control
T25875 24376-24377 -LRB- denotes (
T25876 24377-24381 NN denotes lane
T25877 24382-24383 CD denotes 1
T25878 24383-24384 -RRB- denotes )
T25879 24384-24385 . denotes .
T25880 24386-24387 -LRB- denotes (
T25881 24387-24388 NNP denotes D
T25882 24388-24389 -RRB- denotes )
T25883 24390-24393 DT denotes The
T25884 24394-24397 CD denotes p65
T25885 24398-24401 NNP denotes DNA
T25886 24402-24409 JJ denotes binding
T25887 24410-24418 NN denotes activity
T25888 24419-24422 VBD denotes was
T25889 24423-24431 VBN denotes analysed
T25890 24432-24434 IN denotes by
T25891 24435-24439 NNP denotes EMSA
T25892 24440-24445 VBG denotes using
T25893 24446-24448 IN denotes in
T25894 24449-24454 NN denotes vitro
T25895 24455-24465 VBN denotes translated
T25896 24466-24474 NNS denotes proteins
T25897 24474-24475 . denotes .
T25898 24476-24493 JJ denotes 32P-labeled-NF-κB
T25899 24494-24509 JJ denotes double-stranded
T25900 24510-24525 NN denotes oligonucleotide
T25901 24526-24529 VBD denotes was
T25902 24530-24539 VBN denotes incubated
T25903 24540-24544 IN denotes with
T25904 24545-24548 NNS denotes p65
T25905 24549-24550 -LRB- denotes (
T25906 24550-24553 CD denotes 0.5
T25907 24554-24556 NN denotes µl
T25908 24556-24557 -RRB- denotes )
T25909 24558-24560 IN denotes in
T25910 24561-24569 NN denotes presence
T25911 24570-24572 CC denotes or
T25912 24573-24580 NN denotes absence
T25913 24581-24583 IN denotes of
T25914 24584-24592 NNP denotes HA-IκB-α
T25915 24593-24594 -LRB- denotes (
T25916 24594-24595 CD denotes 1
T25917 24596-24598 NN denotes µl
T25918 24598-24599 -RRB- denotes )
T25919 24599-24600 , denotes ,
T25920 24601-24609 JJ denotes FLAG-Tat
T25921 24610-24612 CC denotes or
T25922 24613-24621 JJ denotes FLAG-Tat
T25923 24622-24623 NN denotes R
T25924 24623-24624 -LRB- denotes (
T25925 24624-24626 CD denotes 49
T25926 24627-24629 CD denotes 57
T25927 24629-24630 -RRB- denotes )
T25928 24630-24631 DT denotes A
T25929 24632-24633 -LRB- denotes (
T25930 24633-24634 CD denotes 5
T25931 24635-24638 CC denotes and
T25932 24639-24641 CD denotes 10
T25933 24642-24644 NN denotes µl
T25934 24644-24645 -RRB- denotes )
T25935 24645-24646 : denotes ;
T25936 24647-24658 NN denotes competition
T25937 24659-24661 IN denotes of
T25938 24662-24665 NNP denotes DNA
T25939 24666-24673 JJ denotes binding
T25940 24674-24677 VBD denotes was
T25941 24678-24687 VBN denotes performed
T25942 24688-24692 IN denotes with
T25943 24693-24695 CD denotes 10
T25944 24696-24697 : denotes -
T25945 24698-24700 RP denotes up
T25946 24701-24703 TO denotes to
T25947 24704-24712 JJ denotes 100-fold
T25948 24713-24718 NN denotes molar
T25949 24719-24725 NN denotes excess
T25950 24726-24728 IN denotes of
T25951 24729-24738 JJ denotes unlabeled
T25952 24739-24744 JJ denotes NF-κB
T25953 24745-24760 JJ denotes double-stranded
T25954 24761-24776 NN denotes oligonucleotide
T25955 24776-24777 . denotes .
T25956 24778-24789 NNP denotes DNA/protein
T25957 24790-24799 NNS denotes complexes
T25958 24800-24804 VBD denotes were
T25959 24805-24808 VBN denotes run
T25960 24809-24811 IN denotes on
T25961 24812-24813 CD denotes 6
T25962 24813-24814 NN denotes %
T25963 24815-24819 NN denotes PAGE
T25964 24820-24823 NNP denotes TBE
T25965 24824-24827 CC denotes and
T25966 24828-24836 VBN denotes analysed
T25967 24837-24839 IN denotes by
T25968 24840-24855 NN denotes autoradiography
T25969 24855-24856 . denotes .
T25970 24857-24858 -LRB- denotes (
T25971 24858-24859 NNP denotes E
T25972 24859-24860 -RRB- denotes )
T25973 24861-24864 FW denotes p50
T25974 24864-24865 FW denotes −
T25975 24865-24866 FW denotes /
T25976 24866-24867 FW denotes −
T25977 24867-24870 FW denotes p65
T25978 24870-24871 FW denotes −
T25979 24871-24872 FW denotes /
T25980 24872-24873 FW denotes −
T25981 24873-24877 NNS denotes MEFs
T25982 24878-24879 -LRB- denotes (
T25983 24879-24880 CD denotes 3
T25984 24881-24882 CD denotes ×
T25985 24883-24886 CD denotes 105
T25986 24887-24892 NNS denotes cells
T25987 24892-24893 -RRB- denotes )
T25988 24894-24898 VBD denotes were
T25989 24899-24910 VBN denotes transfected
T25990 24911-24915 IN denotes with
T25991 24916-24922 NNP denotes pκBLuc
T25992 24923-24924 -LRB- denotes (
T25993 24924-24927 CD denotes 0.5
T25994 24928-24930 NN denotes µg
T25995 24930-24931 -RRB- denotes )
T25996 24932-24935 CC denotes and
T25997 24936-24945 JJ denotes pSV-β-Gal
T25998 24946-24947 -LRB- denotes (
T25999 24947-24950 CD denotes 0.1
T26000 24951-24953 NN denotes µg
T26001 24953-24954 -RRB- denotes )
T26002 24955-24959 IN denotes with
T26003 24960-24962 CC denotes or
T26004 24963-24970 IN denotes without
T26005 24971-24980 NNP denotes pRc/CMV-p
T26006 24980-24982 CD denotes 65
T26007 24983-24984 -LRB- denotes (
T26008 24984-24987 CD denotes 0.5
T26009 24988-24990 NN denotes µg
T26010 24990-24991 -RRB- denotes )
T26011 24991-24992 , denotes ,
T26012 24993-25007 NN denotes pCMV4-HA-IκB-α
T26013 25008-25009 -LRB- denotes (
T26014 25009-25012 CD denotes 0.5
T26015 25013-25015 NN denotes µg
T26016 25015-25016 -RRB- denotes )
T26017 25016-25017 , denotes ,
T26018 25018-25029 NN denotes p3xFLAG-Tat
T26019 25030-25032 CC denotes or
T26020 25033-25044 NN denotes p3xFLAG-Tat
T26021 25045-25046 NN denotes R
T26022 25046-25047 -LRB- denotes (
T26023 25047-25049 CD denotes 49
T26024 25050-25052 CD denotes 57
T26025 25052-25053 -RRB- denotes )
T26026 25053-25054 DT denotes A
T26027 25055-25056 -LRB- denotes (
T26028 25056-25059 CD denotes 0.5
T26029 25059-25060 , denotes ,
T26030 25061-25062 CD denotes 1
T26031 25063-25066 CC denotes and
T26032 25067-25068 CD denotes 2
T26033 25069-25071 NN denotes µg
T26034 25071-25072 -RRB- denotes )
T26035 25072-25073 . denotes .
T26036 25074-25077 DT denotes The
T26037 25078-25088 NN denotes luciferase
T26038 25089-25097 NN denotes activity
T26039 25098-25101 VBD denotes was
T26040 25102-25110 VBN denotes measured
T26041 25111-25113 IN denotes in
T26042 25114-25118 NN denotes cell
T26043 25119-25127 NNS denotes extracts
T26044 25128-25132 JJ denotes 48-h
T26045 25133-25150 NN denotes post-transfection
T26046 25151-25154 CC denotes and
T26047 25155-25165 VBN denotes normalized
T26048 25166-25168 TO denotes to
T26049 25169-25184 JJ denotes β-galactosidase
T26050 25185-25193 NN denotes activity
T26051 25193-25194 . denotes .
T26052 25195-25199 VB denotes Fold
T26053 25200-25210 NN denotes activation
T26054 25211-25214 VBD denotes was
T26055 25215-25225 VBN denotes calculated
T26056 25226-25234 JJ denotes relative
T26057 25235-25237 TO denotes to
T26058 25238-25250 NN denotes transfection
T26059 25251-25253 IN denotes of
T26060 25254-25257 DT denotes the
T26061 25258-25264 NNP denotes pκBLuc
T26062 25265-25272 NN denotes plasmid
T26063 25273-25278 RB denotes alone
T26064 25278-25279 . denotes .
T26065 25280-25286 NNS denotes Values
T26066 25287-25288 -LRB- denotes (
T26067 25288-25292 JJ denotes mean
T26068 25293-25294 NN denotes ±
T26069 25295-25297 NNP denotes SE
T26070 25297-25298 , denotes ,
T26071 25299-25300 JJ denotes n
T26072 25301-25302 SYM denotes =
T26073 25303-25304 LS denotes 3
T26074 25304-25305 -RRB- denotes )
T26075 25306-25309 VBP denotes are
T26076 25310-25315 VBN denotes shown
T26077 25315-25316 . denotes .
T26078 25317-25319 IN denotes As
T26079 25320-25327 NN denotes control
T26080 25328-25330 IN denotes of
T26081 25331-25338 NN denotes protein
T26082 25339-25349 NN denotes expression
T26083 25349-25350 , denotes ,
T26084 25351-25359 NNS denotes aliquots
T26085 25360-25362 IN denotes of
T26086 25363-25367 NN denotes cell
T26087 25368-25376 NNS denotes extracts
T26088 25377-25378 -LRB- denotes (
T26089 25378-25380 CD denotes 20
T26090 25381-25383 NN denotes µg
T26091 25383-25384 -RRB- denotes )
T26092 25385-25389 VBD denotes were
T26093 25390-25398 VBN denotes analysed
T26094 25399-25401 IN denotes by
T26095 25402-25409 JJ denotes western
T26096 25410-25418 VBG denotes blotting
T26097 25419-25423 IN denotes with
T26098 25424-25432 JJ denotes anti-p65
T26099 25432-25433 , denotes ,
T26100 25434-25441 JJ denotes anti-HA
T26101 25441-25442 , denotes ,
T26102 25443-25452 JJ denotes anti-FLAG
T26103 25453-25456 CC denotes and
T26104 25457-25471 JJ denotes anti-γ-tubulin
T26105 25472-25482 NNS denotes antibodies
T26106 25482-25483 . denotes .
T26585 27379-27382 NNP denotes Tat
T26586 27383-27393 NNS denotes associates
T26587 27394-27398 IN denotes with
T26588 27399-27402 CD denotes p65
T26589 27403-27413 VBG denotes increasing
T26590 27414-27417 PRP$ denotes its
T26591 27418-27430 JJ denotes DNA-affinity
T26592 27431-27438 JJ denotes binding
T26593 27438-27439 . denotes .
T26594 27440-27441 -LRB- denotes (
T26595 27441-27442 NNP denotes A
T26596 27442-27443 -RRB- denotes )
T26597 27444-27448 NNP denotes HeLa
T26598 27449-27454 NNS denotes cells
T26599 27455-27459 VBD denotes were
T26600 27460-27471 VBN denotes transfected
T26601 27472-27476 IN denotes with
T26602 27477-27484 NNP denotes pRc/CMV
T26603 27484-27486 CD denotes -3
T26604 27486-27493 NNP denotes xHA-p65
T26605 27494-27495 -LRB- denotes (
T26606 27495-27496 CD denotes 5
T26607 27497-27499 NN denotes µg
T26608 27499-27500 -RRB- denotes )
T26609 27501-27503 IN denotes in
T26610 27504-27512 NN denotes presence
T26611 27513-27515 CC denotes or
T26612 27516-27523 NN denotes absence
T26613 27524-27526 IN denotes of
T26614 27527-27538 NN denotes p3xFLAG-Tat
T26615 27538-27539 , denotes ,
T26616 27540-27551 NN denotes p3xFLAG-Tat
T26617 27552-27553 NNP denotes T
T26618 27553-27554 , denotes ,
T26619 27554-27555 NNP denotes N
T26620 27555-27556 -LRB- denotes (
T26621 27556-27561 CD denotes 23,24
T26622 27561-27562 -RRB- denotes )
T26623 27562-27563 DT denotes A
T26624 27563-27564 , denotes ,
T26625 27565-27576 JJ denotes p3xFLAG-Tat
T26626 27577-27578 NNP denotes K
T26627 27578-27579 -LRB- denotes (
T26628 27579-27584 CD denotes 50,51
T26629 27584-27585 -RRB- denotes )
T26630 27585-27586 DT denotes A
T26631 27586-27587 , denotes ,
T26632 27588-27599 JJ denotes p3xFLAG-Tat
T26633 27600-27601 NN denotes R
T26634 27601-27602 -LRB- denotes (
T26635 27602-27604 CD denotes 49
T26636 27605-27607 CD denotes 57
T26637 27607-27608 -RRB- denotes )
T26638 27608-27609 DT denotes A
T26639 27609-27610 , denotes ,
T26640 27611-27613 CC denotes or
T26641 27614-27625 NN denotes p3xFLAG-Tat
T26642 27626-27627 NNP denotes C
T26643 27627-27628 -LRB- denotes (
T26644 27628-27636 CD denotes 22,25,27
T26645 27636-27637 -RRB- denotes )
T26646 27637-27638 DT denotes A
T26647 27639-27640 -LRB- denotes (
T26648 27640-27641 CD denotes 5
T26649 27642-27644 NN denotes µg
T26650 27644-27645 -RRB- denotes )
T26651 27645-27646 . denotes .
T26652 27647-27655 JJ denotes FLAG-Tat
T26653 27656-27664 NNS denotes proteins
T26654 27665-27669 VBD denotes were
T26655 27670-27688 VBN denotes immunoprecipitated
T26656 27689-27693 IN denotes with
T26657 27694-27703 JJ denotes anti-FLAG
T26658 27704-27712 NN denotes antibody
T26659 27712-27713 : denotes ;
T26660 27714-27729 NNS denotes immunocomplexes
T26661 27730-27734 VBD denotes were
T26662 27735-27744 VBN denotes separated
T26663 27745-27747 IN denotes by
T26664 27748-27750 CD denotes 12
T26665 27750-27751 NN denotes %
T26666 27752-27755 NNP denotes SDS
T26667 27756-27760 NNP denotes PAGE
T26668 27761-27764 CC denotes and
T26669 27765-27773 VBN denotes analysed
T26670 27774-27776 IN denotes by
T26671 27777-27784 JJ denotes western
T26672 27785-27793 VBG denotes blotting
T26673 27794-27798 IN denotes with
T26674 27799-27808 JJ denotes anti-FLAG
T26675 27809-27811 CC denotes or
T26676 27812-27819 JJ denotes anti-HA
T26677 27820-27830 NNS denotes antibodies
T26678 27830-27831 . denotes .
T26679 27832-27833 -LRB- denotes (
T26680 27833-27834 NNP denotes B
T26681 27834-27835 -RRB- denotes )
T26682 27836-27838 IN denotes In
T26683 27839-27844 NN denotes vitro
T26684 27845-27855 VBN denotes translated
T26685 27856-27859 NNS denotes p65
T26686 27860-27861 -LRB- denotes (
T26687 27861-27862 CD denotes 5
T26688 27863-27865 NN denotes µl
T26689 27865-27866 -RRB- denotes )
T26690 27867-27870 VBD denotes was
T26691 27871-27880 VBN denotes incubated
T26692 27881-27885 IN denotes with
T26693 27886-27893 NNP denotes GST-Tat
T26694 27893-27894 , denotes ,
T26695 27895-27902 NNP denotes GST-Tat
T26696 27903-27904 NNP denotes T
T26697 27904-27905 , denotes ,
T26698 27905-27906 NNP denotes N
T26699 27906-27907 -LRB- denotes (
T26700 27907-27912 CD denotes 23,24
T26701 27912-27913 -RRB- denotes )
T26702 27913-27914 DT denotes A
T26703 27914-27915 , denotes ,
T26704 27916-27923 NNP denotes GST-Tat
T26705 27924-27925 NNP denotes K
T26706 27925-27926 -LRB- denotes (
T26707 27926-27931 CD denotes 50,51
T26708 27931-27932 -RRB- denotes )
T26709 27932-27933 DT denotes A
T26710 27933-27934 , denotes ,
T26711 27935-27942 NNP denotes GST-Tat
T26712 27943-27944 NNP denotes R
T26713 27944-27945 -LRB- denotes (
T26714 27945-27947 CD denotes 49
T26715 27948-27950 CD denotes 57
T26716 27950-27951 -RRB- denotes )
T26717 27951-27952 DT denotes A
T26718 27952-27953 , denotes ,
T26719 27954-27961 NNP denotes GST-Tat
T26720 27962-27963 NNP denotes C
T26721 27963-27964 -LRB- denotes (
T26722 27964-27972 CD denotes 22,25,27
T26723 27972-27973 -RRB- denotes )
T26724 27973-27974 DT denotes A
T26725 27974-27975 , denotes ,
T26726 27976-27978 CC denotes or
T26727 27979-27982 NNP denotes GST
T26728 27983-27984 -LRB- denotes (
T26729 27984-27985 CD denotes 5
T26730 27986-27988 NN denotes µg
T26731 27988-27989 -RRB- denotes )
T26732 27990-28000 VBN denotes conjugated
T26733 28001-28005 IN denotes with
T26734 28006-28027 NNP denotes Glutathione-Sepharose
T26735 28027-28028 . denotes .
T26736 28029-28036 NN denotes Protein
T26737 28037-28046 NNS denotes complexes
T26738 28047-28051 VBD denotes were
T26739 28052-28061 VBN denotes recovered
T26740 28062-28064 IN denotes by
T26741 28065-28073 NNP denotes GST-pull
T26742 28074-28078 RB denotes down
T26743 28078-28079 , denotes ,
T26744 28080-28089 VBN denotes separated
T26745 28090-28092 IN denotes by
T26746 28093-28095 CD denotes 12
T26747 28095-28096 NN denotes %
T26748 28097-28100 NNP denotes SDS
T26749 28101-28105 NNP denotes PAGE
T26750 28105-28106 , denotes ,
T26751 28107-28110 CC denotes and
T26752 28111-28119 VBN denotes analysed
T26753 28120-28122 IN denotes by
T26754 28123-28130 JJ denotes western
T26755 28131-28139 VBG denotes blotting
T26756 28140-28144 IN denotes with
T26757 28145-28153 JJ denotes anti-p65
T26758 28154-28156 CC denotes or
T26759 28157-28165 JJ denotes anti-GST
T26760 28166-28176 NNS denotes antibodies
T26761 28176-28177 . denotes .
T26762 28178-28179 -LRB- denotes (
T26763 28179-28180 $ denotes C
T26764 28180-28181 -RRB- denotes )
T26765 28182-28191 JJ denotes Schematic
T26766 28192-28206 NN denotes representation
T26767 28207-28209 IN denotes of
T26768 28210-28219 JJ denotes wild-type
T26769 28220-28223 CC denotes and
T26770 28224-28230 JJ denotes mutant
T26771 28231-28234 NNS denotes p65
T26772 28235-28243 NNS denotes proteins
T26773 28243-28244 . denotes .
T26774 28245-28246 -LRB- denotes (
T26775 28246-28247 NNP denotes D
T26776 28247-28248 -RRB- denotes )
T26777 28249-28253 NNP denotes HeLa
T26778 28254-28259 NNS denotes cells
T26779 28260-28264 VBD denotes were
T26780 28265-28276 VBN denotes transfected
T26781 28277-28281 IN denotes with
T26782 28282-28293 NN denotes p3xFLAG-Tat
T26783 28294-28295 -LRB- denotes (
T26784 28295-28296 CD denotes 5
T26785 28297-28299 NN denotes µg
T26786 28299-28300 -RRB- denotes )
T26787 28301-28303 IN denotes in
T26788 28304-28307 DT denotes the
T26789 28308-28316 NN denotes presence
T26790 28317-28319 CC denotes or
T26791 28320-28327 NN denotes absence
T26792 28328-28330 IN denotes of
T26793 28331-28338 NNP denotes pRc/CMV
T26794 28338-28340 CD denotes -3
T26795 28340-28347 NNP denotes xHA-p65
T26796 28347-28348 , denotes ,
T26797 28349-28356 NNP denotes pRc/CMV
T26798 28356-28358 CD denotes -3
T26799 28358-28367 NN denotes xHA-p65ΔC
T26800 28368-28369 -LRB- denotes (
T26801 28369-28370 CD denotes 1
T26802 28371-28374 CD denotes 318
T26803 28374-28375 -RRB- denotes )
T26804 28375-28376 , denotes ,
T26805 28377-28379 CC denotes or
T26806 28380-28387 NNP denotes pRc/CMV
T26807 28387-28389 CD denotes -3
T26808 28389-28398 NNP denotes xHA-p65ΔN
T26809 28399-28400 -LRB- denotes (
T26810 28400-28403 CD denotes 122
T26811 28404-28407 CD denotes 551
T26812 28407-28408 -RRB- denotes )
T26813 28409-28410 -LRB- denotes (
T26814 28410-28411 CD denotes 5
T26815 28412-28414 NN denotes µg
T26816 28414-28415 -RRB- denotes )
T26817 28415-28416 . denotes .
T26818 28417-28426 JJ denotes Wild-type
T26819 28427-28430 CC denotes and
T26820 28431-28437 JJ denotes mutant
T26821 28438-28444 NN denotes HA-p65
T26822 28445-28453 NNS denotes proteins
T26823 28454-28458 VBD denotes were
T26824 28459-28477 VBN denotes immunoprecipitated
T26825 28478-28482 IN denotes with
T26826 28483-28490 JJ denotes anti-HA
T26827 28491-28499 NN denotes antibody
T26828 28499-28500 : denotes ;
T26829 28501-28516 NNS denotes immunocomplexes
T26830 28517-28521 VBD denotes were
T26831 28522-28531 VBN denotes separated
T26832 28532-28534 IN denotes by
T26833 28535-28537 CD denotes 12
T26834 28537-28538 NN denotes %
T26835 28539-28542 NNP denotes SDS
T26836 28543-28547 NNP denotes PAGE
T26837 28548-28551 CC denotes and
T26838 28552-28560 VBN denotes analysed
T26839 28561-28563 IN denotes by
T26840 28564-28571 JJ denotes western
T26841 28572-28580 VBG denotes blotting
T26842 28581-28585 IN denotes with
T26843 28586-28595 JJ denotes anti-FLAG
T26844 28596-28598 CC denotes or
T26845 28599-28606 JJ denotes anti-HA
T26846 28607-28617 NNS denotes antibodies
T26847 28617-28618 . denotes .
T26848 28619-28620 -LRB- denotes (
T26849 28620-28621 NNP denotes E
T26850 28621-28622 -RRB- denotes )
T26851 28623-28634 JJ denotes Recombinant
T26852 28635-28638 NNS denotes p65
T26853 28639-28646 NN denotes protein
T26854 28647-28648 -LRB- denotes (
T26855 28648-28651 CD denotes 100
T26856 28652-28654 NN denotes ng
T26857 28654-28655 : denotes ;
T26858 28656-28662 NNP denotes Active
T26859 28663-28668 NNP denotes Motif
T26860 28669-28677 NNP denotes Carlsbad
T26861 28677-28678 , denotes ,
T26862 28679-28681 NNP denotes CA
T26863 28681-28682 , denotes ,
T26864 28683-28686 NNP denotes USA
T26865 28686-28687 -RRB- denotes )
T26866 28688-28691 VBD denotes was
T26867 28692-28694 CD denotes 20
T26868 28695-28698 NN denotes min
T26869 28699-28708 VBN denotes incubated
T26870 28709-28713 IN denotes with
T26871 28714-28725 JJ denotes 32P-labeled
T26872 28726-28731 JJ denotes NF-κB
T26873 28732-28747 JJ denotes double-stranded
T26874 28748-28763 NN denotes oligonucleotide
T26875 28764-28766 IN denotes in
T26876 28767-28775 NN denotes presence
T26877 28776-28778 CC denotes or
T26878 28779-28786 NN denotes absence
T26879 28787-28789 IN denotes of
T26880 28790-28792 IN denotes in
T26881 28793-28798 NN denotes vitro
T26882 28799-28809 VBN denotes translated
T26883 28810-28818 NNP denotes FLAG-Tat
T26884 28819-28821 CC denotes or
T26885 28822-28830 NNP denotes FLAG-Tat
T26886 28831-28832 NNP denotes C
T26887 28832-28833 -LRB- denotes (
T26888 28833-28841 CD denotes 22,25,27
T26889 28841-28842 -RRB- denotes )
T26890 28842-28843 DT denotes A
T26891 28844-28845 -LRB- denotes (
T26892 28845-28846 CD denotes 5
T26893 28847-28849 NN denotes µl
T26894 28849-28850 -RRB- denotes )
T26895 28850-28851 : denotes ;
T26896 28852-28864 NNS denotes competitions
T26897 28865-28869 VBD denotes were
T26898 28870-28879 VBN denotes performed
T26899 28880-28884 IN denotes with
T26900 28885-28889 CD denotes 1.25
T26901 28889-28890 : denotes -
T26902 28891-28893 RP denotes up
T26903 28894-28896 TO denotes to
T26904 28897-28904 JJ denotes 40-fold
T26905 28905-28910 NN denotes molar
T26906 28911-28917 NN denotes excess
T26907 28918-28920 IN denotes of
T26908 28921-28930 JJ denotes unlabeled
T26909 28931-28946 NN denotes oligonucleotide
T26910 28946-28947 . denotes .
T26911 28948-28959 NNP denotes DNA/protein
T26912 28960-28969 NNS denotes complexes
T26913 28970-28974 VBD denotes were
T26914 28975-28984 VBN denotes separated
T26915 28985-28987 IN denotes by
T26916 28988-28989 CD denotes 6
T26917 28989-28990 NN denotes %
T26918 28991-28995 NN denotes PAGE
T26919 28996-28998 IN denotes in
T26920 28999-29002 CD denotes 0.5
T26921 29003-29004 CD denotes ×
T26922 29005-29008 NNP denotes TBE
T26923 29009-29015 NN denotes buffer
T26924 29016-29019 CC denotes and
T26925 29020-29028 VBN denotes analysed
T26926 29029-29031 IN denotes by
T26927 29032-29047 NN denotes autoradiography
T26928 29047-29048 . denotes .
T26929 29049-29050 -LRB- denotes (
T26930 29050-29051 NN denotes F
T26931 29051-29052 -RRB- denotes )
T26932 29053-29065 NN denotes Densitometry
T26933 29066-29068 IN denotes of
T26934 29069-29080 NNS denotes band-shifts
T26935 29081-29086 VBN denotes shown
T26936 29087-29089 IN denotes in
T26937 29090-29092 NNP denotes E.
T27629 31394-31397 NNP denotes Tat
T27630 31398-31407 VBZ denotes activates
T27631 31408-31411 DT denotes the
T27632 31412-31425 JJ denotes p65-dependent
T27633 31426-31436 NN denotes expression
T27634 31437-31439 IN denotes of
T27635 31440-31456 JJ denotes NF-κB-responsive
T27636 31457-31462 NNS denotes genes
T27637 31463-31465 IN denotes by
T27638 31466-31475 VBG denotes occupying
T27639 31476-31479 DT denotes the
T27640 31480-31485 JJ denotes NF-κB
T27641 31486-31495 NNS denotes enhancers
T27642 31496-31499 CC denotes and
T27643 31500-31509 VBG denotes promoting
T27644 31510-31513 DT denotes the
T27645 31514-31517 CD denotes p65
T27646 31518-31529 NN denotes recruitment
T27647 31530-31534 IN denotes with
T27648 31535-31540 JJ denotes IκB-α
T27649 31541-31553 NN denotes displacement
T27650 31553-31554 . denotes .
T27651 31555-31559 NNP denotes HeLa
T27652 31560-31565 NNS denotes cells
T27653 31566-31567 -LRB- denotes (
T27654 31567-31568 CD denotes 5
T27655 31569-31570 CD denotes ×
T27656 31571-31574 CD denotes 106
T27657 31574-31575 -RRB- denotes )
T27658 31576-31580 VBD denotes were
T27659 31581-31592 VBN denotes transfected
T27660 31593-31597 IN denotes with
T27661 31598-31609 NN denotes p3xFLAG-Tat
T27662 31609-31610 , denotes ,
T27663 31611-31622 NN denotes p3xFLAG-Tat
T27664 31623-31624 NNP denotes C
T27665 31624-31625 -LRB- denotes (
T27666 31625-31633 CD denotes 22,25,27
T27667 31633-31634 -RRB- denotes )
T27668 31634-31635 , denotes ,
T27669 31636-31647 JJ denotes p3xFLAG-Tat
T27670 31648-31649 NN denotes R
T27671 31649-31650 -LRB- denotes (
T27672 31650-31652 CD denotes 49
T27673 31653-31655 CD denotes 57
T27674 31655-31656 -RRB- denotes )
T27675 31657-31659 CC denotes or
T27676 31660-31665 JJ denotes empty
T27677 31666-31672 NN denotes vector
T27678 31673-31674 -LRB- denotes (
T27679 31674-31676 CD denotes 10
T27680 31677-31679 NN denotes µg
T27681 31679-31680 -RRB- denotes )
T27682 31680-31681 : denotes ;
T27683 31682-31685 IN denotes for
T27684 31686-31689 CD denotes p65
T27685 31690-31693 NNP denotes RNA
T27686 31694-31706 NN denotes interference
T27687 31706-31707 , denotes ,
T27688 31708-31713 NNS denotes cells
T27689 31714-31715 -LRB- denotes (
T27690 31715-31716 CD denotes 5
T27691 31717-31718 CD denotes ×
T27692 31719-31722 CD denotes 106
T27693 31722-31723 -RRB- denotes )
T27694 31724-31728 VBD denotes were
T27695 31729-31740 VBN denotes transfected
T27696 31741-31745 IN denotes with
T27697 31746-31757 NN denotes p3xFLAG-Tat
T27698 31758-31759 -LRB- denotes (
T27699 31759-31761 CD denotes 10
T27700 31762-31764 NN denotes µg
T27701 31764-31765 -RRB- denotes )
T27702 31766-31769 CC denotes and
T27703 31770-31775 NNP denotes siRNA
T27704 31776-31779 CD denotes p65
T27705 31780-31782 CC denotes or
T27706 31783-31788 JJ denotes siRNA
T27707 31789-31796 NN denotes control
T27708 31797-31798 -LRB- denotes (
T27709 31798-31801 CD denotes 200
T27710 31802-31806 NN denotes pmol
T27711 31806-31807 -RRB- denotes )
T27712 31807-31808 . denotes .
T27713 31809-31825 CD denotes Twenty-four-hour
T27714 31826-31843 JJ denotes post-transfection
T27715 31843-31844 , denotes ,
T27716 31845-31850 JJ denotes total
T27717 31851-31854 NNP denotes RNA
T27718 31855-31858 VBD denotes was
T27719 31859-31868 VBN denotes extracted
T27720 31869-31872 CC denotes and
T27721 31873-31881 VBN denotes analysed
T27722 31882-31884 IN denotes by
T27723 31885-31894 JJ denotes real-time
T27724 31895-31898 NNP denotes PCR
T27725 31899-31901 TO denotes to
T27726 31902-31910 VB denotes evaluate
T27727 31911-31914 DT denotes the
T27728 31915-31925 NN denotes expression
T27729 31926-31928 IN denotes of
T27730 31929-31935 NNP denotes MIP-1α
T27731 31936-31937 -LRB- denotes (
T27732 31937-31938 NNP denotes A
T27733 31938-31939 -RRB- denotes )
T27734 31939-31940 , denotes ,
T27735 31941-31945 NNP denotes CSF3
T27736 31946-31947 -LRB- denotes (
T27737 31947-31948 NNP denotes B
T27738 31948-31949 -RRB- denotes )
T27739 31949-31950 , denotes ,
T27740 31951-31954 NNP denotes LTA
T27741 31955-31956 -LRB- denotes (
T27742 31956-31957 NNP denotes C
T27743 31957-31958 -RRB- denotes )
T27744 31958-31959 , denotes ,
T27745 31960-31966 NNP denotes NFKBIA
T27746 31967-31968 -LRB- denotes (
T27747 31968-31969 NNP denotes D
T27748 31969-31970 -RRB- denotes )
T27749 31970-31971 , denotes ,
T27750 31972-31976 NNP denotes TLR2
T27751 31977-31978 -LRB- denotes (
T27752 31978-31979 NNP denotes E
T27753 31979-31980 -RRB- denotes )
T27754 31980-31981 , denotes ,
T27755 31982-31987 NNP denotes GAPDH
T27756 31988-31989 -LRB- denotes (
T27757 31989-31990 NN denotes F
T27758 31990-31991 -RRB- denotes )
T27759 31991-31992 , denotes ,
T27760 31993-31997 NNP denotes ACTB
T27761 31998-31999 -LRB- denotes (
T27762 31999-32000 NNP denotes G
T27763 32000-32001 -RRB- denotes )
T27764 32002-32007 NNS denotes genes
T27765 32007-32008 . denotes .
T27766 32009-32010 -LRB- denotes (
T27767 32010-32011 NNP denotes H
T27768 32011-32012 -RRB- denotes )
T27769 32013-32017 NNP denotes HeLa
T27770 32018-32023 NNS denotes cells
T27771 32024-32025 -LRB- denotes (
T27772 32025-32026 CD denotes 5
T27773 32027-32028 CD denotes ×
T27774 32029-32032 CD denotes 106
T27775 32032-32033 -RRB- denotes )
T27776 32034-32038 VBD denotes were
T27777 32039-32050 VBN denotes transfected
T27778 32051-32055 IN denotes with
T27779 32056-32067 NN denotes p3xFLAG-Tat
T27780 32067-32068 , denotes ,
T27781 32069-32071 CC denotes or
T27782 32072-32077 JJ denotes empty
T27783 32078-32084 NN denotes vector
T27784 32085-32086 -LRB- denotes (
T27785 32086-32088 CD denotes 10
T27786 32089-32091 NN denotes µg
T27787 32091-32092 -RRB- denotes )
T27788 32093-32096 CC denotes and
T27789 32097-32099 CD denotes 48
T27790 32100-32101 NN denotes h
T27791 32102-32107 RB denotes later
T27792 32108-32112 NNP denotes ChIP
T27793 32113-32116 VBD denotes was
T27794 32117-32126 VBN denotes performed
T27795 32127-32131 IN denotes with
T27796 32132-32140 JJ denotes anti-p65
T27797 32141-32149 NN denotes antibody
T27798 32149-32150 . denotes .
T27799 32151-32160 JJ denotes Real-time
T27800 32161-32164 NNP denotes PCR
T27801 32165-32168 VBD denotes was
T27802 32169-32178 VBN denotes performed
T27803 32179-32183 IN denotes with
T27804 32184-32191 NNS denotes primers
T27805 32192-32200 JJ denotes specific
T27806 32201-32204 IN denotes for
T27807 32205-32208 DT denotes the
T27808 32209-32218 VBN denotes indicated
T27809 32219-32228 NNS denotes promoters
T27810 32228-32229 . denotes .
T27811 32230-32231 -LRB- denotes (
T27812 32231-32232 PRP denotes I
T27813 32232-32233 -RRB- denotes )
T27814 32234-32238 NNP denotes HeLa
T27815 32239-32244 NNS denotes cells
T27816 32245-32246 -LRB- denotes (
T27817 32246-32247 CD denotes 5
T27818 32248-32249 CD denotes ×
T27819 32250-32253 CD denotes 106
T27820 32253-32254 -RRB- denotes )
T27821 32255-32259 VBD denotes were
T27822 32260-32271 VBN denotes transfected
T27823 32272-32276 IN denotes with
T27824 32277-32282 JJ denotes empty
T27825 32283-32289 NN denotes vector
T27826 32289-32290 , denotes ,
T27827 32291-32293 CC denotes or
T27828 32294-32305 NN denotes p3xFLAG-Tat
T27829 32306-32307 -LRB- denotes (
T27830 32307-32309 CD denotes 10
T27831 32310-32312 NN denotes µg
T27832 32312-32313 -RRB- denotes )
T27833 32314-32316 IN denotes in
T27834 32317-32325 NN denotes presence
T27835 32326-32328 CC denotes or
T27836 32329-32336 NN denotes absence
T27837 32337-32339 IN denotes of
T27838 32340-32345 NNP denotes siRNA
T27839 32346-32349 CD denotes p65
T27840 32349-32350 , denotes ,
T27841 32351-32353 CC denotes or
T27842 32354-32359 NN denotes siRNA
T27843 32360-32367 NN denotes control
T27844 32368-32369 -LRB- denotes (
T27845 32369-32372 CD denotes 200
T27846 32373-32377 NN denotes pmol
T27847 32377-32378 -RRB- denotes )
T27848 32378-32379 : denotes ;
T27849 32380-32382 CD denotes 48
T27850 32383-32384 NN denotes h
T27851 32385-32390 RB denotes later
T27852 32390-32391 , denotes ,
T27853 32392-32396 NNP denotes ChIP
T27854 32397-32400 VBD denotes was
T27855 32401-32410 VBN denotes performed
T27856 32411-32415 IN denotes with
T27857 32416-32425 JJ denotes anti-FLAG
T27858 32426-32434 NN denotes antibody
T27859 32434-32435 . denotes .
T27860 32436-32445 JJ denotes Real-time
T27861 32446-32449 NNP denotes PCR
T27862 32450-32453 VBD denotes was
T27863 32454-32463 VBN denotes performed
T27864 32464-32468 IN denotes with
T27865 32469-32476 NNS denotes primers
T27866 32477-32485 JJ denotes specific
T27867 32486-32489 IN denotes for
T27868 32490-32493 DT denotes the
T27869 32494-32503 VBN denotes indicated
T27870 32504-32513 NNS denotes promoters
T27871 32513-32514 . denotes .
T27872 32515-32516 -LRB- denotes (
T27873 32516-32517 NNP denotes J
T27874 32517-32518 -RRB- denotes )
T27875 32519-32523 NNP denotes HeLa
T27876 32524-32529 NNS denotes cells
T27877 32530-32531 -LRB- denotes (
T27878 32531-32532 CD denotes 5
T27879 32533-32534 CD denotes ×
T27880 32535-32538 CD denotes 106
T27881 32538-32539 -RRB- denotes )
T27882 32540-32544 VBD denotes were
T27883 32545-32556 VBN denotes transfected
T27884 32557-32561 IN denotes with
T27885 32562-32567 JJ denotes empty
T27886 32568-32574 NN denotes vector
T27887 32574-32575 , denotes ,
T27888 32576-32587 NN denotes p3xFLAG-Tat
T27889 32588-32589 -LRB- denotes (
T27890 32589-32591 CD denotes 10
T27891 32592-32594 NN denotes µg
T27892 32594-32595 -RRB- denotes )
T27893 32595-32596 , denotes ,
T27894 32597-32599 CC denotes or
T27895 32600-32605 JJ denotes empty
T27896 32606-32612 NN denotes vector
T27897 32613-32617 CC denotes plus
T27898 32618-32623 NNP denotes siRNA
T27899 32624-32629 NNP denotes IκB-α
T27900 32630-32632 CC denotes or
T27901 32633-32638 NNP denotes siRNA
T27902 32639-32646 NN denotes control
T27903 32647-32648 -LRB- denotes (
T27904 32648-32651 CD denotes 200
T27905 32652-32656 NN denotes pmol
T27906 32656-32657 -RRB- denotes )
T27907 32657-32658 : denotes ;
T27908 32659-32661 CD denotes 48
T27909 32662-32663 NN denotes h
T27910 32664-32669 RB denotes later
T27911 32669-32670 , denotes ,
T27912 32671-32675 NNP denotes ChIP
T27913 32676-32679 VBD denotes was
T27914 32680-32689 VBN denotes performed
T27915 32690-32694 IN denotes with
T27916 32695-32705 JJ denotes anti-IκB-α
T27917 32706-32714 NN denotes antibody
T27918 32714-32715 . denotes .
T27919 32716-32725 JJ denotes Real-time
T27920 32726-32729 NNP denotes PCR
T27921 32730-32733 VBD denotes was
T27922 32734-32743 VBN denotes performed
T27923 32744-32748 IN denotes with
T27924 32749-32756 NNS denotes primers
T27925 32757-32765 JJ denotes specific
T27926 32766-32769 IN denotes for
T27927 32770-32773 DT denotes the
T27928 32774-32783 VBN denotes indicated
T27929 32784-32793 NNS denotes promoters
T27930 32793-32794 . denotes .
T27931 32795-32801 NNS denotes Values
T27932 32802-32803 -LRB- denotes (
T27933 32803-32807 JJ denotes mean
T27934 32808-32809 NN denotes ±
T27935 32810-32812 NNP denotes SE
T27936 32812-32813 , denotes ,
T27937 32814-32815 JJ denotes n
T27938 32816-32817 SYM denotes =
T27939 32818-32819 LS denotes 3
T27940 32819-32820 -RRB- denotes )
T27941 32821-32824 VBP denotes are
T27942 32825-32830 VBN denotes shown
T27943 32830-32831 . denotes .
T27944 32832-32835 DT denotes The
T27945 32836-32845 NNS denotes asterisks
T27946 32846-32854 VBP denotes indicate
T27947 32855-32868 RB denotes statistically
T27948 32869-32880 JJ denotes significant
T27949 32881-32892 NNS denotes differences
T27950 32893-32901 VBN denotes compared
T27951 32902-32904 TO denotes to
T27952 32905-32908 DT denotes the
T27953 32909-32916 NN denotes control
T27954 32917-32918 -LRB- denotes (
T27955 32918-32923 JJ denotes empty
T27956 32924-32930 NN denotes vector
T27957 32930-32931 -RRB- denotes )
T27958 32932-32941 VBG denotes according
T27959 32942-32944 TO denotes to
T27960 32945-32948 DT denotes the
T27961 32949-32956 NN denotes Student
T27962 32956-32958 POS denotes 's
T27963 32959-32965 JJS denotes t-test
T27964 32966-32967 -LRB- denotes (
T27965 32967-32968 NNP denotes P
T27966 32969-32970 CD denotes <
T27967 32971-32975 CD denotes 0.05
T27968 32975-32976 -RRB- denotes )
T27969 32976-32977 . denotes .
T28367 35881-35883 IN denotes In
T28368 35884-35889 JJ denotes HIV-1
T28369 35890-35899 NN denotes infection
T28370 35900-35903 NNP denotes Tat
T28371 35904-35912 VBZ denotes sustains
T28372 35913-35916 DT denotes the
T28373 35917-35922 JJ denotes NF-κB
T28374 35923-35931 NN denotes activity
T28375 35932-35935 CC denotes and
T28376 35936-35944 VBZ denotes enhances
T28377 35945-35948 DT denotes the
T28378 35949-35955 JJ denotes MIP-1α
T28379 35956-35966 NN denotes expression
T28380 35967-35970 IN denotes via
T28381 35971-35982 NN denotes interaction
T28382 35983-35987 IN denotes with
T28383 35988-35993 NNP denotes IκB-α
T28384 35994-35997 CC denotes and
T28385 35998-36001 NNS denotes p65
T28386 36001-36002 . denotes .
T28387 36003-36007 CD denotes U937
T28388 36008-36013 NNS denotes cells
T28389 36014-36015 -LRB- denotes (
T28390 36015-36016 CD denotes 5
T28391 36017-36018 RB denotes ×
T28392 36019-36022 CD denotes 107
T28393 36022-36023 -RRB- denotes )
T28394 36024-36028 VBD denotes were
T28395 36029-36040 VBN denotes transfected
T28396 36041-36045 IN denotes with
T28397 36046-36051 NNP denotes siRNA
T28398 36052-36055 NNP denotes Tat
T28399 36055-36056 , denotes ,
T28400 36057-36062 NNP denotes siRNA
T28401 36063-36070 NN denotes control
T28402 36071-36072 -LRB- denotes (
T28403 36072-36073 CD denotes 2
T28404 36074-36078 NN denotes nmol
T28405 36078-36079 -RRB- denotes )
T28406 36079-36080 , denotes ,
T28407 36081-36083 CC denotes or
T28408 36084-36088 VBD denotes left
T28409 36089-36102 JJ denotes untransfected
T28410 36102-36103 : denotes ;
T28411 36104-36106 CD denotes 24
T28412 36107-36108 NN denotes h
T28413 36109-36114 RB denotes later
T28414 36115-36120 NNS denotes cells
T28415 36121-36125 VBD denotes were
T28416 36126-36134 VBN denotes infected
T28417 36135-36139 IN denotes with
T28418 36140-36156 JJ denotes HXB2-pseudotyped
T28419 36157-36162 NN denotes NL4-3
T28420 36162-36163 . denotes .
T28421 36163-36171 NN denotes FLAG-Tat
T28422 36171-36172 . denotes .
T28423 36172-36173 NN denotes R
T28424 36173-36174 NN denotes −
T28425 36174-36175 NNP denotes E
T28426 36175-36176 CD denotes −
T28427 36177-36184 NNS denotes virions
T28428 36185-36186 -LRB- denotes (
T28429 36186-36189 CD denotes 500
T28430 36190-36192 NN denotes ng
T28431 36193-36195 IN denotes of
T28432 36196-36199 CD denotes p24
T28433 36199-36200 -RRB- denotes )
T28434 36201-36204 CC denotes and
T28435 36205-36214 VBD denotes harvested
T28436 36215-36217 IN denotes at
T28437 36218-36221 DT denotes the
T28438 36222-36231 JJ denotes indicated
T28439 36232-36236 NN denotes time
T28440 36236-36237 . denotes .
T28441 36238-36239 -LRB- denotes (
T28442 36239-36240 NNP denotes A
T28443 36240-36241 -RRB- denotes )
T28444 36242-36251 JJ denotes Real-time
T28445 36252-36255 NNP denotes PCR
T28446 36256-36258 IN denotes of
T28447 36259-36264 JJ denotes total
T28448 36265-36268 NNP denotes RNA
T28449 36269-36277 VBD denotes measured
T28450 36278-36281 DT denotes the
T28451 36282-36285 NNP denotes Tat
T28452 36286-36296 NN denotes expression
T28453 36296-36297 : denotes ;
T28454 36298-36303 NNP denotes ELISA
T28455 36304-36312 VBD denotes measured
T28456 36313-36316 DT denotes the
T28457 36317-36323 NN denotes amount
T28458 36324-36326 IN denotes of
T28459 36327-36330 CD denotes p24
T28460 36331-36333 IN denotes in
T28461 36334-36339 JJ denotes whole
T28462 36340-36344 NN denotes cell
T28463 36345-36353 NNS denotes extracts
T28464 36353-36354 . denotes .
T28465 36355-36356 -LRB- denotes (
T28466 36356-36357 NNP denotes B
T28467 36357-36358 -RRB- denotes )
T28468 36359-36362 DT denotes The
T28469 36363-36370 JJ denotes binding
T28470 36371-36373 IN denotes of
T28471 36374-36377 CD denotes p65
T28472 36378-36380 TO denotes to
T28473 36381-36384 DT denotes the
T28474 36385-36390 NNP denotes NF-κB
T28475 36391-36406 JJ denotes double-stranded
T28476 36407-36422 NN denotes oligonucleotide
T28477 36423-36426 VBD denotes was
T28478 36427-36435 VBN denotes measured
T28479 36436-36438 IN denotes in
T28480 36439-36446 JJ denotes nuclear
T28481 36447-36455 NNS denotes extracts
T28482 36456-36457 -LRB- denotes (
T28483 36457-36459 CD denotes 10
T28484 36460-36462 NN denotes µg
T28485 36462-36463 -RRB- denotes )
T28486 36464-36469 VBG denotes using
T28487 36470-36473 DT denotes the
T28488 36474-36479 NNP denotes NF-κB
T28489 36480-36493 NNP denotes Transcription
T28490 36494-36500 NNP denotes Factor
T28491 36501-36506 NNP denotes ELISA
T28492 36507-36512 NN denotes assay
T28493 36513-36516 NN denotes kit
T28494 36517-36518 -LRB- denotes (
T28495 36518-36524 NNP denotes Cayman
T28496 36524-36525 -RRB- denotes )
T28497 36525-36526 . denotes .
T28498 36527-36528 -LRB- denotes (
T28499 36528-36529 $ denotes C
T28500 36529-36530 -RRB- denotes )
T28501 36531-36534 DT denotes The
T28502 36535-36540 JJ denotes IκB-α
T28503 36541-36548 NN denotes content
T28504 36549-36552 VBD denotes was
T28505 36553-36561 VBN denotes analysed
T28506 36562-36564 IN denotes by
T28507 36565-36567 CD denotes 12
T28508 36567-36568 NN denotes %
T28509 36569-36572 NNP denotes SDS
T28510 36573-36577 NNP denotes PAGE
T28511 36578-36581 CC denotes and
T28512 36582-36589 JJ denotes western
T28513 36590-36598 VBG denotes blotting
T28514 36599-36601 IN denotes of
T28515 36602-36611 JJ denotes cytosolic
T28516 36612-36620 NNS denotes extracts
T28517 36621-36622 -LRB- denotes (
T28518 36622-36624 CD denotes 20
T28519 36625-36627 NN denotes µg
T28520 36627-36628 -RRB- denotes )
T28521 36629-36634 VBG denotes using
T28522 36635-36645 JJ denotes anti-IκB-α
T28523 36646-36654 NN denotes antibody
T28524 36654-36655 . denotes .
T28525 36656-36668 NNP denotes Densitometry
T28526 36669-36675 NNS denotes values
T28527 36676-36677 -LRB- denotes (
T28528 36677-36678 NNP denotes D
T28529 36678-36679 -RRB- denotes )
T28530 36680-36682 IN denotes of
T28531 36683-36686 DT denotes the
T28532 36687-36692 NNS denotes bands
T28533 36693-36697 VBD denotes were
T28534 36698-36707 VBN denotes expressed
T28535 36708-36710 IN denotes as
T28536 36711-36715 VBP denotes fold
T28537 36716-36724 NN denotes increase
T28538 36725-36730 IN denotes above
T28539 36731-36734 DT denotes the
T28540 36735-36742 NN denotes control
T28541 36743-36744 -LRB- denotes (
T28542 36744-36748 JJ denotes mock
T28543 36748-36749 -RRB- denotes )
T28544 36749-36750 . denotes .
T28545 36751-36752 -LRB- denotes (
T28546 36752-36753 NNP denotes D
T28547 36753-36754 -RRB- denotes )
T28548 36755-36758 NNP denotes IKK
T28549 36759-36767 NN denotes activity
T28550 36768-36771 VBD denotes was
T28551 36772-36780 VBN denotes measured
T28552 36781-36783 IN denotes in
T28553 36784-36793 JJ denotes cytosolic
T28554 36794-36798 NN denotes cell
T28555 36799-36807 NNS denotes extracts
T28556 36808-36809 -LRB- denotes (
T28557 36809-36812 CD denotes 100
T28558 36813-36815 NN denotes µg
T28559 36815-36816 -RRB- denotes )
T28560 36817-36822 VBG denotes using
T28561 36823-36829 NNP denotes HTScan
T28562 36830-36833 NNP denotes IKK
T28563 36834-36840 NNP denotes Kinase
T28564 36841-36846 NNP denotes Assay
T28565 36847-36848 -LRB- denotes (
T28566 36848-36852 NNP denotes Cell
T28567 36853-36862 NNP denotes Signaling
T28568 36863-36873 NNP denotes Technology
T28569 36873-36874 -RRB- denotes )
T28570 36874-36875 . denotes .
T28571 36876-36877 -LRB- denotes (
T28572 36877-36878 NNP denotes E
T28573 36878-36879 -RRB- denotes )
T28574 36880-36884 NNP denotes U937
T28575 36885-36890 NNS denotes cells
T28576 36891-36892 -LRB- denotes (
T28577 36892-36893 CD denotes 5
T28578 36894-36895 RB denotes ×
T28579 36896-36899 CD denotes 107
T28580 36899-36900 -RRB- denotes )
T28581 36901-36905 VBD denotes were
T28582 36906-36914 VBN denotes infected
T28583 36915-36919 IN denotes with
T28584 36920-36936 JJ denotes HXB2-pseudotyped
T28585 36937-36942 NN denotes NL4-3
T28586 36942-36943 . denotes .
T28587 36943-36951 NN denotes FLAG-Tat
T28588 36951-36952 . denotes .
T28589 36952-36953 NN denotes R
T28590 36953-36954 NN denotes −
T28591 36954-36955 NNP denotes E
T28592 36955-36956 CD denotes −
T28593 36957-36964 NNS denotes virions
T28594 36964-36965 , denotes ,
T28595 36966-36968 CC denotes or
T28596 36969-36973 VBD denotes left
T28597 36974-36984 JJ denotes uninfected
T28598 36984-36985 . denotes .
T28599 36986-37002 CD denotes Twenty-four-hour
T28600 37003-37017 NN denotes post-infection
T28601 37017-37018 , denotes ,
T28602 37019-37023 NN denotes cell
T28603 37024-37032 NNS denotes extracts
T28604 37033-37034 -LRB- denotes (
T28605 37034-37035 CD denotes 1
T28606 37036-37038 NN denotes mg
T28607 37038-37039 -RRB- denotes )
T28608 37040-37044 VBD denotes were
T28609 37045-37063 VBN denotes immunoprecipitated
T28610 37064-37068 IN denotes with
T28611 37069-37076 NN denotes protein
T28612 37077-37096 JJ denotes G-Sepharose-coupled
T28613 37097-37106 JJ denotes anti-FLAG
T28614 37107-37115 NN denotes antibody
T28615 37115-37116 . denotes .
T28616 37117-37132 NNS denotes Immunocomplexes
T28617 37133-37137 VBD denotes were
T28618 37138-37147 VBN denotes separated
T28619 37148-37150 IN denotes by
T28620 37151-37153 CD denotes 12
T28621 37153-37154 NN denotes %
T28622 37155-37158 NNP denotes SDS
T28623 37159-37163 NNP denotes PAGE
T28624 37164-37167 CC denotes and
T28625 37168-37176 VBN denotes analysed
T28626 37177-37179 IN denotes by
T28627 37180-37187 JJ denotes western
T28628 37188-37196 VBG denotes blotting
T28629 37197-37201 IN denotes with
T28630 37202-37210 JJ denotes anti-p65
T28631 37210-37211 , denotes ,
T28632 37212-37221 JJ denotes anti-FLAG
T28633 37222-37225 CC denotes and
T28634 37226-37236 JJ denotes anti-IκB-α
T28635 37237-37247 NNS denotes antibodies
T28636 37247-37248 . denotes .
T28637 37249-37250 -LRB- denotes (
T28638 37250-37251 NN denotes F
T28639 37251-37252 -RRB- denotes )
T28640 37253-37257 NNP denotes U937
T28641 37258-37263 NNS denotes cells
T28642 37264-37265 -LRB- denotes (
T28643 37265-37266 CD denotes 5
T28644 37267-37268 RB denotes ×
T28645 37269-37272 CD denotes 107
T28646 37272-37273 -RRB- denotes )
T28647 37274-37278 VBD denotes were
T28648 37279-37290 VBN denotes transfected
T28649 37291-37295 IN denotes with
T28650 37296-37301 NNP denotes siRNA
T28651 37302-37305 NNP denotes Tat
T28652 37305-37306 , denotes ,
T28653 37307-37312 NNP denotes siRNA
T28654 37313-37316 CD denotes p65
T28655 37316-37317 , denotes ,
T28656 37318-37323 NNP denotes siRNA
T28657 37324-37331 NN denotes control
T28658 37332-37333 -LRB- denotes (
T28659 37333-37334 CD denotes 2
T28660 37335-37339 NN denotes nmol
T28661 37339-37340 -RRB- denotes )
T28662 37340-37341 , denotes ,
T28663 37342-37344 CC denotes or
T28664 37345-37349 VBD denotes left
T28665 37350-37363 JJ denotes untransfected
T28666 37363-37364 : denotes ;
T28667 37365-37367 CD denotes 24
T28668 37368-37369 NN denotes h
T28669 37370-37375 RB denotes later
T28670 37375-37376 , denotes ,
T28671 37377-37382 NNS denotes cells
T28672 37383-37387 VBD denotes were
T28673 37388-37396 VBN denotes infected
T28674 37397-37401 IN denotes with
T28675 37402-37418 JJ denotes HXB2-pseudotyped
T28676 37419-37424 NN denotes NL4-3
T28677 37424-37425 . denotes .
T28678 37425-37433 NN denotes FLAG-Tat
T28679 37433-37434 . denotes .
T28680 37434-37435 NN denotes R
T28681 37435-37436 NN denotes −
T28682 37436-37437 NNP denotes E
T28683 37437-37438 CD denotes −
T28684 37439-37446 NNS denotes virions
T28685 37446-37447 , denotes ,
T28686 37448-37450 CC denotes or
T28687 37451-37455 VBD denotes left
T28688 37456-37466 JJ denotes uninfected
T28689 37466-37467 . denotes .
T28690 37468-37484 CD denotes Twenty-four-hour
T28691 37485-37499 JJ denotes post-infection
T28692 37499-37500 , denotes ,
T28693 37501-37506 JJ denotes total
T28694 37507-37510 NNP denotes RNA
T28695 37511-37514 VBD denotes was
T28696 37515-37523 VBN denotes analysed
T28697 37524-37527 IN denotes for
T28698 37528-37534 JJ denotes MIP-1α
T28699 37535-37545 NN denotes expression
T28700 37546-37548 IN denotes by
T28701 37549-37558 JJ denotes real-time
T28702 37559-37562 NNP denotes PCR
T28703 37562-37563 . denotes .
T28704 37564-37565 -LRB- denotes (
T28705 37565-37566 NNP denotes G
T28706 37567-37570 CC denotes and
T28707 37571-37572 NNP denotes H
T28708 37572-37573 -RRB- denotes )
T28709 37574-37578 NNP denotes U937
T28710 37579-37584 NNS denotes cells
T28711 37585-37586 -LRB- denotes (
T28712 37586-37587 CD denotes 5
T28713 37588-37589 RB denotes ×
T28714 37590-37593 CD denotes 107
T28715 37593-37594 -RRB- denotes )
T28716 37595-37599 VBD denotes were
T28717 37600-37611 VBN denotes transfected
T28718 37612-37616 IN denotes with
T28719 37617-37622 NNP denotes siRNA
T28720 37623-37626 NNP denotes Tat
T28721 37627-37629 CC denotes or
T28722 37630-37635 NNP denotes siRNA
T28723 37636-37643 NN denotes control
T28724 37644-37645 -LRB- denotes (
T28725 37645-37646 CD denotes 2
T28726 37647-37651 NN denotes nmol
T28727 37651-37652 -RRB- denotes )
T28728 37652-37653 , denotes ,
T28729 37654-37656 CC denotes or
T28730 37657-37661 VBD denotes left
T28731 37662-37675 JJ denotes untransfected
T28732 37675-37676 : denotes ;
T28733 37677-37679 CD denotes 24
T28734 37680-37681 NN denotes h
T28735 37682-37687 RB denotes later
T28736 37687-37688 , denotes ,
T28737 37689-37694 NNS denotes cells
T28738 37695-37699 VBD denotes were
T28739 37700-37708 VBN denotes infected
T28740 37709-37713 IN denotes with
T28741 37714-37730 JJ denotes HXB2-pseudotyped
T28742 37731-37736 NN denotes NL4-3
T28743 37736-37737 . denotes .
T28744 37737-37745 NN denotes FLAG-Tat
T28745 37745-37746 . denotes .
T28746 37746-37747 NN denotes R
T28747 37747-37748 NN denotes −
T28748 37748-37749 NNP denotes E
T28749 37749-37750 CD denotes −
T28750 37751-37758 NNS denotes virions
T28751 37758-37759 , denotes ,
T28752 37760-37762 CC denotes or
T28753 37763-37767 VBD denotes left
T28754 37768-37778 JJ denotes uninfected
T28755 37778-37779 . denotes .
T28756 37780-37796 CD denotes Twenty-four-hour
T28757 37797-37811 NN denotes post-infection
T28758 37811-37812 , denotes ,
T28759 37813-37817 NNP denotes ChIP
T28760 37818-37821 VBD denotes was
T28761 37822-37831 VBN denotes performed
T28762 37832-37836 IN denotes with
T28763 37837-37845 JJ denotes anti-p65
T28764 37846-37847 -LRB- denotes (
T28765 37847-37848 NNP denotes G
T28766 37848-37849 -RRB- denotes )
T28767 37850-37852 CC denotes or
T28768 37853-37862 JJ denotes anti-FLAG
T28769 37863-37864 -LRB- denotes (
T28770 37864-37865 NNP denotes H
T28771 37865-37866 -RRB- denotes )
T28772 37866-37867 . denotes .
T28773 37868-37877 JJ denotes Real-time
T28774 37878-37881 NNP denotes PCR
T28775 37882-37885 VBD denotes was
T28776 37886-37895 VBN denotes performed
T28777 37896-37900 IN denotes with
T28778 37901-37908 NNS denotes primers
T28779 37909-37917 JJ denotes specific
T28780 37918-37921 IN denotes for
T28781 37922-37928 NNP denotes MIP-1α
T28782 37929-37932 CC denotes and
T28783 37933-37938 NNP denotes GAPDH
T28784 37939-37948 NNS denotes promoters
T28785 37948-37949 . denotes .
T28786 37950-37956 NNS denotes Values
T28787 37957-37958 -LRB- denotes (
T28788 37958-37962 JJ denotes mean
T28789 37963-37964 NN denotes ±
T28790 37965-37967 NNP denotes SE
T28791 37967-37968 , denotes ,
T28792 37969-37970 JJ denotes n
T28793 37971-37972 SYM denotes =
T28794 37973-37974 LS denotes 3
T28795 37974-37975 -RRB- denotes )
T28796 37976-37979 VBP denotes are
T28797 37980-37985 VBN denotes shown
T28798 37985-37986 . denotes .
T28799 37987-37990 DT denotes The
T28800 37991-38000 NNS denotes asterisks
T28801 38001-38009 VBP denotes indicate
T28802 38010-38023 RB denotes statistically
T28803 38024-38035 JJ denotes significant
T28804 38036-38047 NNS denotes differences
T28805 38048-38056 VBN denotes compared
T28806 38057-38059 TO denotes to
T28807 38060-38063 DT denotes the
T28808 38064-38071 NN denotes control
T28809 38072-38073 -LRB- denotes (
T28810 38073-38077 JJ denotes mock
T28811 38077-38078 -RRB- denotes )
T28812 38078-38079 , denotes ,
T28813 38080-38089 VBG denotes according
T28814 38090-38092 TO denotes to
T28815 38093-38096 DT denotes the
T28816 38097-38104 NN denotes Student
T28817 38104-38106 POS denotes 's
T28818 38107-38113 JJS denotes t-test
T28819 38114-38115 -LRB- denotes (
T28820 38115-38116 NNP denotes P
T28821 38117-38118 CD denotes <
T28822 38119-38123 CD denotes 0.05
T28823 38123-38124 -RRB- denotes )
T28824 38124-38125 . denotes .
T29196 43632-43637 NNP denotes Model
T29197 43638-43640 IN denotes of
T29198 43641-43647 NNP denotes MIP-1α
T29199 43648-43663 JJ denotes transcriptional
T29200 43664-43674 NN denotes activation
T29201 43675-43677 IN denotes by
T29202 43678-43683 NNP denotes HIV-1
T29203 43684-43687 NNP denotes Tat
T29204 43687-43688 . denotes .
T29205 43689-43690 -LRB- denotes (
T29206 43690-43691 NNP denotes A
T29207 43691-43692 -RRB- denotes )
T29208 43693-43695 IN denotes In
T29209 43696-43703 NN denotes absence
T29210 43704-43706 IN denotes of
T29211 43707-43710 NNP denotes Tat
T29212 43710-43711 , denotes ,
T29213 43712-43717 NNP denotes IκB-α
T29214 43718-43726 VBZ denotes occupies
T29215 43727-43730 DT denotes the
T29216 43731-43736 JJ denotes NF-κB
T29217 43737-43745 NN denotes enhancer
T29218 43746-43748 IN denotes of
T29219 43749-43752 DT denotes the
T29245 43882-43891 VBZ denotes activates
T29246 43892-43895 DT denotes the
T29247 43896-43902 JJ denotes MIP-1α
T29248 43903-43913 NN denotes expression
T29249 43914-43916 IN denotes by
T29250 43917-43925 VBG denotes removing
T29251 43926-43929 DT denotes the
T29252 43930-43935 JJ denotes IκB-α
T29253 43936-43945 NN denotes repressor
T29254 43946-43950 IN denotes from
T29255 43951-43954 DT denotes the
T29256 43955-43960 NNP denotes NF-κB
T29257 43961-43969 NN denotes enhancer
T29258 43969-43970 , denotes ,
T29259 43971-43974 CC denotes and
T29260 43975-43977 IN denotes by
T29261 43978-43988 VBG denotes increasing
T29262 43989-43992 DT denotes the
T29263 43993-44000 JJ denotes binding
T29264 44001-44003 IN denotes of
T29265 44004-44007 CD denotes p65
T29266 44008-44013 JJ denotes NF-κB
T29267 44014-44021 NN denotes complex
T29268 44022-44024 TO denotes to
T29269 44025-44028 DT denotes the
T29270 44029-44034 JJ denotes NF-κB
T29271 44035-44043 NN denotes enhancer
T29272 44043-44044 . denotes .
T7557 12455-12456 -RRB- denotes )
T7558 12457-12459 IN denotes at
T7559 12460-12463 DT denotes the
T7560 12464-12469 JJ denotes final
T7561 12470-12483 NN denotes concentration
T7562 12484-12486 IN denotes of
T7563 12487-12488 CD denotes 1
T7564 12488-12489 NN denotes %
T7565 12489-12490 . denotes .
T7566 12491-12496 IN denotes After
T7567 12497-12499 CD denotes 10
T7568 12500-12503 NN denotes min
T7569 12503-12504 , denotes ,
T7570 12505-12513 JJ denotes ice-cold
T7571 12514-12517 NNP denotes PBS
T7572 12518-12522 CC denotes plus
T7573 12523-12528 CD denotes 0.125
T7574 12529-12530 NNP denotes M
T7575 12531-12538 NN denotes glycine
T7576 12539-12542 VBD denotes was
T7577 12543-12548 VBN denotes added
T7578 12548-12549 , denotes ,
T7579 12550-12553 CC denotes and
T7580 12554-12560 NNS denotes plates
T7581 12561-12565 VBD denotes were
T7582 12566-12577 VBN denotes transferred
T7583 12578-12580 IN denotes on
T7584 12581-12584 NN denotes ice
T7585 12584-12585 , denotes ,
T7586 12586-12592 VBD denotes washed
T7587 12593-12604 RB denotes extensively
T7588 12605-12609 IN denotes with
T7880 13889-13891 NNP denotes mM
T7881 13892-13896 NNP denotes EDTA
T7882 13896-13897 -RRB- denotes )
T7883 13897-13898 , denotes ,
T7884 13899-13902 CC denotes and
T7885 13903-13912 VBN denotes extracted
T7886 13913-13915 IN denotes in
T7887 13916-13918 NNP denotes TE
T7888 13919-13925 NN denotes buffer
T7889 13926-13936 VBG denotes containing
T7890 13937-13938 CD denotes 2
T7891 13938-13939 NN denotes %
T7892 13940-13943 NNP denotes SDS
T7893 13943-13944 . denotes .
T7894 13945-13952 NN denotes Protein
T7895 13953-13956 NNP denotes DNA
T7896 13957-13968 NNS denotes cross-links
T7897 13969-13973 VBD denotes were
T7898 13974-13982 VBN denotes reverted
T7899 13983-13985 IN denotes by
T7900 13986-13993 NN denotes heating
T7901 13994-13996 IN denotes at
T7902 13997-13999 CD denotes 65
T7903 13999-14000 CD denotes °
T7904 14000-14001 NNP denotes C
T7905 14002-14011 JJ denotes overnight
T7906 14011-14012 . denotes .
T7907 14013-14016 NNP denotes DNA
T7908 14017-14020 VBD denotes was
T7909 14021-14028 JJ denotes further
T7910 14029-14037 VBN denotes purified
T7911 14038-14040 IN denotes by
T7912 14041-14049 NNP denotes QIAquick
T7913 14050-14053 NNP denotes PCR
T7914 14054-14066 NN denotes purification
T7945 14243-14250 VBZ denotes eluates
T7946 14251-14256 VBG denotes using
T7947 14257-14261 NNP denotes SYBR
T7948 14262-14269 NNP denotes GreenER
T7949 14270-14276 NNP denotes Master
T7950 14277-14280 NNP denotes Mix
T7951 14281-14282 -LRB- denotes (
T7952 14282-14292 NNP denotes Invitrogen
T7953 14292-14293 -RRB- denotes )
T7954 14293-14294 . denotes .
T7955 14295-14304 NNS denotes Reactions
T21629 41779-41782 NNS denotes p65
T21630 41783-41787 IN denotes from
T21631 41788-41791 DT denotes the
T21632 41792-41797 JJ denotes IκB-α
T21633 41798-41808 NN denotes inhibition
T21634 41808-41809 . denotes .
T21635 41810-41820 RB denotes Altogether
T21636 41821-41826 DT denotes these
T21637 41827-41834 NNS denotes results
T21638 41835-41847 VBD denotes demonstrated
T21639 41848-41852 IN denotes that
T21640 41853-41856 NNP denotes Tat
T21641 41857-41866 VBD denotes abolished
T21642 41867-41870 DT denotes the
T21643 41871-41879 JJ denotes negative
T21644 41880-41888 NN denotes feedback
T21645 41889-41899 NN denotes regulation
T21646 41900-41902 IN denotes of
T21647 41903-41908 NN denotes NF-κB
T21648 41909-41911 IN denotes by
T21649 41912-41921 VBG denotes hijacking
T21650 41922-41925 DT denotes the
T21651 41926-41931 JJ denotes IκB-α
T21652 41932-41941 NN denotes repressor
T21653 41941-41942 , denotes ,
T21654 41943-41952 VBG denotes shielding
T21655 41953-41956 NNS denotes p65
T21656 41957-41961 IN denotes from
T21657 41962-41965 DT denotes the
T21658 41966-41971 JJ denotes IκB-α
T21659 41972-41979 VBP denotes embrace
T21660 41979-41980 , denotes ,
T21661 41981-41984 CC denotes and
T21662 41985-41994 VBG denotes enforcing
T21663 41995-41998 DT denotes the
T21664 41999-42002 CD denotes p65
T21665 42003-42010 JJ denotes binding
T21666 42011-42013 TO denotes to
T21667 42014-42017 NNP denotes DNA
T21668 42017-42018 . denotes .
T21669 42019-42026 JJ denotes Further
T21670 42027-42035 NN denotes evidence
T21671 42036-42038 IN denotes of
T21672 42039-42042 NNP denotes Tat
T24106 16873-16876 CC denotes and
T24107 16877-16887 NNP denotes Hexokinase
T24108 16888-16890 NNP denotes II
T24109 16891-16895 VBD denotes were
T24110 16896-16904 VBN denotes detected
T24111 16905-16909 IN denotes with
T24112 16910-16918 JJ denotes specific
T24113 16919-16929 NNS denotes antibodies
T29220 43753-43759 JJ denotes MIP-1α
T29221 43760-43768 NN denotes promoter
T29222 43769-43772 CC denotes and
T29223 43773-43779 JJ denotes likely
T29224 43780-43789 NNS denotes interacts
T29225 43790-43794 IN denotes with
T29226 43795-43810 JJ denotes transcriptional
T29227 43811-43821 NNS denotes repressors
T29228 43821-43822 , denotes ,
T29229 43823-43827 JJ denotes such
T29230 43828-43830 IN denotes as
T29231 43831-43836 NNS denotes HDACs
T29232 43837-43838 -LRB- denotes (
T29233 43838-43840 CD denotes 65
T29234 43840-43841 -RRB- denotes )
T29235 43841-43842 , denotes ,
T29236 43843-43845 TO denotes to
T29237 43846-43853 VB denotes inhibit
T29238 43854-43858 NN denotes gene
T29239 43859-43872 NN denotes transcription
T29240 43872-43873 . denotes .
T29241 43874-43875 -LRB- denotes (
T29242 43875-43876 NNP denotes B
T29243 43876-43877 -RRB- denotes )
T29244 43878-43881 NNP denotes Tat
R293 T402 T403 amod Human,immunodeficiency
R294 T403 T405 compound immunodeficiency,Tat
R295 T404 T405 compound virus-1,Tat
R296 T405 T406 nsubj Tat,activates
R297 T406 T422 ccomp activates,is
R298 T407 T406 dobj NF-κB,activates
R299 T408 T406 prep via,activates
R300 T409 T410 amod physical,interaction
R301 T410 T408 pobj interaction,via
R302 T411 T410 prep with,interaction
R303 T412 T411 pobj IκB-α,with
R304 T413 T412 cc and,IκB-α
R305 T414 T416 nummod p65,factor
R306 T415 T416 amod Nuclear,factor
R307 T416 T410 conj factor,interaction
R308 T417 T410 punct (,interaction
R309 T418 T406 npadvmod NF,activates
R310 T419 T418 punct ),NF
R311 T420 T422 punct -,is
R312 T421 T422 nsubj κB,is
R313 T422 T422 ROOT is,is
R314 T423 T425 det a,regulator
R315 T424 T425 compound master,regulator
R316 T425 T422 attr regulator,is
R317 T426 T425 prep of,regulator
R318 T427 T428 amod pro-inflammatory,genes
R319 T428 T426 pobj genes,of
R320 T429 T422 cc and,is
R321 T430 T431 auxpass is,upregulated
R322 T431 T422 conj upregulated,is
R323 T432 T431 prep in,upregulated
R324 T433 T434 amod human,immunodeficiency
R325 T434 T435 compound immunodeficiency,virus
R326 T435 T432 pobj virus,in
R327 T436 T435 nummod 1,virus
R328 T437 T440 punct (,infection
R329 T438 T440 nmod HIV-1,infection
R330 T439 T440 punct ),infection
R331 T440 T435 appos infection,virus
R332 T441 T422 punct .,is
R333 T442 T449 nsubj Mechanisms,are
R334 T443 T442 acl underlying,Mechanisms
R335 T444 T446 det the,deregulation
R336 T445 T446 amod NF-κB,deregulation
R337 T446 T443 dobj deregulation,underlying
R338 T447 T446 prep by,deregulation
R339 T448 T447 pobj HIV-1,by
R340 T449 T449 ROOT are,are
R341 T450 T449 acomp relevant,are
R342 T451 T450 prep for,relevant
R343 T452 T453 amod immune,dysfunction
R344 T453 T451 pobj dysfunction,for
R345 T454 T453 prep in,dysfunction
R346 T455 T454 pobj AIDS,in
R347 T456 T449 punct .,are
R348 T457 T458 nsubj We,report
R349 T458 T458 ROOT report,report
R350 T459 T475 mark that,activated
R351 T460 T475 prep in,activated
R352 T461 T464 amod single,infection
R353 T462 T464 compound round,infection
R354 T463 T464 compound HIV-1,infection
R355 T464 T460 pobj infection,in
R356 T465 T460 punct ",",in
R357 T466 T460 cc or,in
R358 T467 T469 amod single-pulse,stimulation
R359 T468 T469 compound PMA,stimulation
R360 T469 T475 dep stimulation,activated
R361 T470 T475 punct ",",activated
R362 T471 T474 det the,transactivator
R363 T472 T474 compound HIV-1,transactivator
R364 T473 T474 compound Tat,transactivator
R365 T474 T475 nsubj transactivator,activated
R366 T475 T458 ccomp activated,report
R367 T476 T475 dobj NF-κB,activated
R368 T477 T475 prep by,activated
R369 T478 T477 pcomp hijacking,by
R370 T479 T481 det the,IκB-α
R371 T480 T481 compound inhibitor,IκB-α
R372 T481 T478 dobj IκB-α,hijacking
R373 T482 T477 cc and,by
R374 T483 T477 conj by,by
R375 T484 T483 pcomp preventing,by
R376 T485 T486 det the,repressor
R377 T486 T484 dobj repressor,preventing
R378 T487 T484 oprd binding,preventing
R379 T488 T487 prep to,binding
R380 T489 T491 det the,complex
R381 T490 T491 amod NF-κB,complex
R382 T491 T488 pobj complex,to
R383 T492 T458 punct .,report
R384 T493 T496 advmod Moreover,associated
R385 T494 T496 punct ",",associated
R386 T495 T496 npadvmod Tat,associated
R387 T496 T496 ROOT associated,associated
R388 T497 T496 prep with,associated
R389 T498 T500 det the,subunit
R390 T499 T500 nummod p65,subunit
R391 T500 T497 pobj subunit,with
R392 T501 T500 prep of,subunit
R393 T502 T501 pobj NF-κB,of
R394 T503 T496 cc and,associated
R395 T504 T496 conj increased,associated
R396 T505 T508 det the,affinity
R397 T506 T508 nummod p65,affinity
R398 T507 T508 amod DNA-binding,affinity
R399 T508 T504 dobj affinity,increased
R400 T509 T508 cc and,affinity
R401 T510 T511 compound transcriptional,activity
R402 T511 T508 conj activity,affinity
R403 T512 T496 punct .,associated
R404 T513 T518 det The,domains
R405 T514 T518 nmod arginine,domains
R406 T515 T514 punct -,arginine
R407 T516 T514 cc and,arginine
R408 T517 T518 amod cysteine-rich,domains
R409 T518 T522 nsubjpass domains,required
R410 T519 T518 prep of,domains
R411 T520 T519 pobj Tat,of
R412 T521 T522 auxpass were,required
R413 T522 T522 ROOT required,required
R414 T523 T522 prep for,required
R415 T524 T523 pobj IκB-α,for
R416 T525 T524 cc and,IκB-α
R417 T526 T527 nummod p65,association
R418 T527 T524 conj association,IκB-α
R419 T528 T527 punct ",",association
R420 T529 T527 advmod respectively,association
R421 T530 T527 punct ",",association
R422 T531 T523 cc and,for
R423 T532 T523 conj for,for
R424 T533 T532 pcomp sustaining,for
R425 T534 T536 det the,activity
R426 T535 T536 compound NF-κB,activity
R427 T536 T533 dobj activity,sustaining
R428 T537 T522 punct .,required
R429 T538 T547 prep Among,activated
R430 T539 T540 det an,array
R431 T540 T538 pobj array,Among
R432 T541 T540 prep of,array
R433 T542 T543 amod NF-κB-responsive,genes
R434 T543 T541 pobj genes,of
R435 T544 T547 punct ",",activated
R436 T545 T547 nsubj Tat,activated
R437 T546 T547 advmod mostly,activated
R438 T547 T547 ROOT activated,activated
R439 T548 T550 det the,expression
R440 T549 T550 amod MIP-1α,expression
R441 T550 T547 dobj expression,activated
R442 T551 T547 prep in,activated
R443 T552 T554 det a,manner
R444 T553 T554 amod p65-dependent,manner
R445 T554 T551 pobj manner,in
R446 T555 T547 punct ",",activated
R447 T556 T547 cc and,activated
R448 T557 T547 conj bound,activated
R449 T558 T557 prep to,bound
R450 T559 T562 det the,enhancer
R451 T560 T562 compound MIP-1α,enhancer
R452 T561 T562 compound NF-κB,enhancer
R453 T562 T558 pobj enhancer,to
R454 T563 T564 advmod thus,promoting
R455 T564 T557 conj promoting,bound
R456 T565 T566 det the,recruitment
R465 T574 T575 amod similar,findings
R466 T575 T577 nsubjpass findings,obtained
R467 T576 T577 auxpass were,obtained
R468 T577 T547 conj obtained,activated
R469 T578 T577 prep for,obtained
R470 T579 T581 det the,genes
R471 T580 T581 amod NF-κB-responsive,genes
R472 T581 T578 pobj genes,for
R473 T582 T581 appos CSF3,genes
R474 T583 T582 punct ",",CSF3
R475 T584 T582 conj LTA,CSF3
R476 T585 T584 punct ",",LTA
R477 T586 T584 conj NFKBIA,LTA
R478 T587 T586 cc and,NFKBIA
R479 T588 T586 conj TLR2,NFKBIA
R480 T589 T577 punct .,obtained
R481 T590 T591 poss Our,results
R482 T591 T592 nsubj results,support
R483 T592 T592 ROOT support,support
R484 T593 T595 det a,mechanism
R485 T594 T595 amod novel,mechanism
R486 T595 T592 dobj mechanism,support
R487 T596 T595 prep of,mechanism
R488 T597 T598 amod NF-κB,activation
R489 T598 T596 pobj activation,of
R490 T599 T592 prep via,support
R491 T600 T601 amod physical,interaction
R492 T601 T599 pobj interaction,via
R493 T602 T601 prep of,interaction
R494 T603 T602 pobj Tat,of
R495 T604 T601 prep with,interaction
R496 T605 T604 pobj IκB-α,with
R497 T606 T605 cc and,IκB-α
R498 T607 T605 conj p65,IκB-α
R499 T608 T592 punct ",",support
R500 T609 T592 cc and,support
R501 T610 T611 aux may,contribute
R502 T611 T592 conj contribute,support
R503 T612 T611 prep to,contribute
R504 T613 T614 amod further,insights
R505 T614 T612 pobj insights,to
R506 T615 T614 prep into,insights
R507 T616 T617 det the,deregulation
R508 T617 T615 pobj deregulation,into
R509 T618 T617 prep of,deregulation
R510 T619 T621 det the,response
R511 T620 T621 amod inflammatory,response
R512 T621 T618 pobj response,of
R513 T622 T621 prep by,response
R514 T623 T622 pobj HIV-1,by
R515 T624 T592 punct .,support
R2065 T2329 T2330 compound Nuclear,factor
R2066 T2330 T2337 nmod factor,factors
R2067 T2331 T2332 punct (,NF
R2068 T2332 T2330 appos NF,factor
R2069 T2333 T2332 punct ),NF
R2070 T2334 T2335 punct -,κB
R2071 T2335 T2337 amod κB,factors
R2072 T2336 T2337 compound transcription,factors
R2073 T2337 T2338 nsubj factors,regulate
R2074 T2338 T2338 ROOT regulate,regulate
R2075 T2339 T2340 det the,transcription
R2076 T2340 T2338 dobj transcription,regulate
R2077 T2341 T2340 prep of,transcription
R2078 T2342 T2341 pobj genes,of
R2079 T2343 T2345 nsubjpass that,involved
R2080 T2344 T2345 auxpass are,involved
R2081 T2377 T2378 compound homology,domain
R2082 T2345 T2342 relcl involved,genes
R2083 T2346 T2345 prep in,involved
R2084 T2378 T2370 dobj domain,share
R2085 T2347 T2351 det the,response
R2086 T2348 T2351 amod immune,response
R2087 T2379 T2380 punct (,RHD
R2088 T2380 T2378 appos RHD,domain
R2089 T2349 T2348 cc and,immune
R2090 T2381 T2360 punct ),RelA/p65
R2091 T2350 T2348 conj inflammatory,immune
R2092 T2351 T2346 pobj response,in
R2093 T2352 T2353 punct (,1
R2094 T2353 T2342 appos 1,genes
R2095 T2382 T2359 prep for,includes
R2096 T2354 T2353 punct ),1
R2097 T2355 T2338 punct .,regulate
R2098 T2356 T2358 det The,family
R2099 T2357 T2358 compound NF-κB,family
R2100 T2358 T2359 nsubj family,includes
R2101 T2359 T2359 ROOT includes,includes
R2102 T2383 T2382 pobj homo,for
R2103 T2360 T2359 dobj RelA/p65,includes
R2104 T2361 T2360 punct ",",RelA/p65
R2105 T2362 T2360 conj c-Rel,RelA/p65
R2106 T2363 T2362 punct ",",c-Rel
R2107 T2384 T2383 punct -,homo
R2108 T2364 T2362 conj RelB,c-Rel
R2109 T2365 T2364 punct ",",RelB
R2110 T2366 T2364 conj p50,RelB
R2111 T2385 T2383 cc or,homo
R2112 T2367 T2366 cc and,p50
R2113 T2368 T2366 conj p52,p50
R2114 T2369 T2370 nsubj that,share
R2115 T2370 T2368 relcl share,p52
R2116 T2386 T2383 conj hetero-dimerization,homo
R2117 T2371 T2378 det a,domain
R2118 T2372 T2373 advmod highly,conserved
R2119 T2373 T2378 amod conserved,domain
R2120 T2374 T2375 amod 300-amino,acid
R2121 T2387 T2386 cc and,hetero-dimerization
R2122 T2375 T2378 compound acid,domain
R2123 T2376 T2378 compound Rel,domain
R2124 T2388 T2386 conj DNA-binding,hetero-dimerization
R2125 T2389 T2359 punct .,includes
R2126 T2390 T2392 det The,activity
R2127 T2391 T2392 amod transcriptional,activity
R2128 T2392 T2397 nsubj activity,depends
R2129 T2474 T2471 relcl releases,degradation
R2130 T2475 T2478 det the,complex
R2131 T2476 T2478 amod functional,complex
R2132 T2393 T2392 prep of,activity
R2133 T2477 T2478 compound NF-κB,complex
R2134 T2478 T2474 dobj complex,releases
R2135 T2394 T2397 det the,depends
R2136 T2479 T2478 prep in,complex
R2137 T2480 T2481 det the,nucleus
R2138 T2481 T2479 pobj nucleus,in
R2139 T2395 T2397 nsubj NF-κB,depends
R2140 T2482 T2457 punct .,phosphorylates
R2141 T2483 T2496 nsubjpass IκB-α,phosphorylated
R2142 T2484 T2483 punct ",",IκB-α
R2143 T2396 T2397 nsubj complex,depends
R2144 T2485 T2488 det the,inhibitor
R2145 T2486 T2487 advmod most,abundant
R2146 T2397 T2397 ROOT depends,depends
R2147 T2487 T2488 amod abundant,inhibitor
R2148 T2488 T2483 appos inhibitor,IκB-α
R2149 T2489 T2488 prep of,inhibitor
R2150 T2490 T2489 pobj NF-κB,of
R2151 T2491 T2492 punct (,4
R2152 T2398 T2397 prep on,depends
R2153 T2492 T2490 appos 4,NF-κB
R2154 T2399 T2400 amod dimer,composition
R2155 T2493 T2492 punct ),4
R2156 T2494 T2496 punct ",",phosphorylated
R2157 T2400 T2398 pobj composition,on
R2158 T2495 T2496 auxpass is,phosphorylated
R2159 T2496 T2496 ROOT phosphorylated,phosphorylated
R2160 T2497 T2496 agent by,phosphorylated
R2161 T2401 T2407 mark since,are
R2162 T2498 T2497 pobj IKK,by
R2163 T2499 T2496 prep at,phosphorylated
R2164 T2402 T2406 amod C-terminal,domains
R2165 T2500 T2499 pobj Ser32,at
R2166 T2501 T2500 cc and,Ser32
R2167 T2502 T2500 conj Ser36,Ser32
R2168 T2403 T2406 amod unrelated,domains
R2169 T2503 T2504 punct (,5
R2170 T2504 T2502 parataxis 5,Ser36
R2171 T2404 T2406 amod transcriptional,domains
R2172 T2405 T2406 compound activation,domains
R2173 T2505 T2504 punct ),5
R2174 T2506 T2502 punct ",",Ser36
R2175 T2406 T2407 nsubj domains,are
R2176 T2507 T2502 cc and,Ser36
R2177 T2508 T2509 advmod subsequently,ubiquitylated
R2178 T2509 T2509 ROOT ubiquitylated,ubiquitylated
R2179 T2407 T2397 advcl are,depends
R2180 T2510 T2509 prep at,ubiquitylated
R2181 T2511 T2510 pobj Lys21,at
R2182 T2512 T2511 cc and,Lys21
R2183 T2408 T2407 acomp present,are
R2184 T2513 T2511 conj Lys22,Lys21
R2185 T2514 T2516 aux to,degraded
R2186 T2515 T2516 auxpass be,degraded
R2187 T2409 T2408 advmod exclusively,present
R2188 T2516 T2509 xcomp degraded,ubiquitylated
R2189 T2517 T2516 agent by,degraded
R2190 T2518 T2520 det the,proteasome
R2191 T2410 T2407 prep in,are
R2192 T2519 T2520 amod 26S,proteasome
R2193 T2520 T2517 pobj proteasome,by
R2194 T2521 T2522 punct (,6
R2195 T2411 T2410 pobj p65,in
R2196 T2522 T2520 appos 6,proteasome
R2198 T2523 T2520 punct ),proteasome
R2199 T2524 T2496 punct .,phosphorylated
R2200 T2525 T2527 det The,activity
R2201 T2526 T2527 amod NF-κB,activity
R2202 T2527 T2529 nsubjpass activity,enhanced
R2203 T2528 T2529 auxpass is,enhanced
R2204 T2529 T2529 ROOT enhanced,enhanced
R2205 T2530 T2529 agent by,enhanced
R2206 T2531 T2530 pobj phosphorylation,by
R2207 T2532 T2531 prep of,phosphorylation
R2208 T2533 T2532 pobj p65,of
R2210 T2534 T2529 prep at,enhanced
R2211 T2535 T2534 pobj Ser276,at
R2212 T2536 T2529 agent by,enhanced
R2213 T2537 T2536 pobj PKA,by
R2215 T2538 T2537 cc and,PKA
R2216 T2539 T2537 conj MSK1,PKA
R2217 T2540 T2539 punct (,MSK1
R2219 T2541 T2539 parataxis "7,8",MSK1
R2220 T2542 T2539 punct ),MSK1
R2221 T2543 T2537 punct ",",PKA
R2223 T2544 T2537 conj Ser311,PKA
R2224 T2545 T2529 agent by,enhanced
R2225 T2546 T2545 pobj PKCζ,by
R2227 T2547 T2548 punct (,9
R2228 T2548 T2546 parataxis 9,PKCζ
R2229 T2549 T2548 punct ),9
R2231 T2550 T2546 cc and,PKCζ
R2232 T2551 T2546 conj Ser536,PKCζ
R2233 T2552 T2529 agent by,enhanced
R2234 T2553 T2552 pobj IKKα,by
R2236 T2554 T2555 punct (,"10,11"
R2237 T2555 T2553 parataxis "10,11",IKKα
R2238 T2556 T2529 punct ),enhanced
R2240 T2557 T2529 punct .,enhanced
R2241 T2558 T2565 nsubj Acetylation,increases
R2242 T2559 T2558 prep of,Acetylation
R2243 T2560 T2559 pobj p65,of
R2245 T2561 T2558 prep at,Acetylation
R2246 T2562 T2561 pobj Lys218,at
R2248 T2563 T2562 cc and,Lys218
R2249 T2564 T2562 conj Lys221,Lys218
R2250 T2565 T2565 ROOT increases,increases
R2251 T2566 T2567 det the,DNA
R2252 T2567 T2565 dobj DNA,increases
R2253 T2568 T2565 advcl binding,increases
R2255 T2569 T2565 cc and,increases
R2256 T2570 T2565 conj impairs,increases
R2260 T2427 T2426 prep with,associate
R2261 T2571 T2572 det the,association
R2262 T2572 T2570 dobj association,impairs
R2263 T2573 T2572 prep with,association
R2264 T2574 T2573 pobj IκB-α,with
R2265 T2428 T2430 det the,complex
R2266 T2575 T2574 punct ",",IκB-α
R2267 T2576 T2572 cc and,association
R2268 T2577 T2572 conj acetylation,association
R2269 T2429 T2430 compound NF-κB,complex
R2270 T2578 T2570 prep at,impairs
R2271 T2579 T2578 pobj Lys310,at
R2272 T2430 T2427 pobj complex,with
R2273 T2580 T2565 conj enhances,increases
R2274 T2581 T2584 det the,activity
R2275 T2582 T2584 nummod p65,activity
R2276 T2431 T2420 cc and,Inhibitors
R2277 T2583 T2584 amod transcriptional,activity
R2278 T2584 T2580 dobj activity,enhances
R2279 T2585 T2584 punct (,activity
R2280 T2432 T2432 ROOT interfere,interfere
R2281 T2586 T2584 appos "12,13",activity
R2282 T2587 T2584 punct ),activity
R2283 T2588 T2565 punct .,increases
R2284 T2433 T2432 prep with,interfere
R2285 T2589 T2590 nsubj Post-activation,turn
R2286 T2590 T2595 nsubjpass turn,regulated
R2287 T2591 T2590 prt off,turn
R2288 T2434 T2435 poss its,binding
R2289 T2592 T2591 prep of,off
R2290 T2593 T2592 pobj NF-κB,of
R2291 T2594 T2595 auxpass is,regulated
R2292 T2435 T2433 pobj binding,with
R2293 T2595 T2595 ROOT regulated,regulated
R2294 T2596 T2595 agent by,regulated
R2295 T2597 T2599 amod negative,loop
R2296 T2436 T2435 prep to,binding
R2297 T2598 T2599 compound feedback,loop
R2298 T2599 T2596 pobj loop,by
R2299 T2600 T2595 prep through,regulated
R2300 T2601 T2600 pobj inhibitors,through
R2301 T2602 T2601 prep under,inhibitors
R2302 T2603 T2605 det the,control
R2303 T2437 T2436 pobj DNA,to
R2304 T2604 T2605 amod transcriptional,control
R2305 T2605 T2602 pobj control,under
R2306 T2606 T2605 prep of,control
R2307 T2607 T2606 pobj NF-κB,of
R2308 T2438 T2439 punct (,3
R2309 T2608 T2601 punct ",",inhibitors
R2310 T2609 T2610 amod such,as
R2311 T2610 T2601 prep as,inhibitors
R2312 T2439 T2437 appos 3,DNA
R2313 T2440 T2439 punct ),3
R2314 T2611 T2615 amod IκB-α,A20
R2315 T2441 T2432 punct .,interfere
R2316 T2612 T2611 cc and,IκB-α
R2317 T2613 T2611 conj ubiquitin-editing,IκB-α
R2318 T2614 T2615 compound protein,A20
R2319 T2442 T2457 prep In,phosphorylates
R2320 T2615 T2610 pobj A20,as
R2321 T2616 T2615 punct (,A20
R2322 T2617 T2615 appos 14,A20
R2323 T2443 T2445 det the,pathway
R2324 T2618 T2617 prep 20,14
R2325 T2619 T2617 punct ),14
R2326 T2620 T2595 punct .,regulated
R2327 T2444 T2445 amod canonical,pathway
R2328 T2621 T2638 nsubj Deacetylation,down-regulate
R2329 T2622 T2621 prep of,Deacetylation
R2330 T2623 T2622 pobj p65,of
R2331 T2445 T2442 pobj pathway,In
R2332 T2624 T2621 prep by,Deacetylation
R2333 T2625 T2624 pobj histone,by
R2334 T2626 T2621 conj deacetylase-3,Deacetylation
R2335 T2446 T2445 prep of,pathway
R2336 T2627 T2626 cc or,deacetylase-3
R2337 T2628 T2626 conj SIRT1,deacetylase-3
R2338 T2629 T2628 punct ",",SIRT1
R2339 T2447 T2448 amod NF-κB,activation
R2340 T2630 T2628 cc or,SIRT1
R2341 T2631 T2628 conj acetylation,SIRT1
R2342 T2632 T2631 prep of,acetylation
R2343 T2633 T2632 pobj p65,of
R2344 T2448 T2446 pobj activation,of
R2345 T2634 T2631 prep at,acetylation
R2346 T2635 T2634 pobj Lys122,at
R2347 T2636 T2635 cc and,Lys122
R2348 T2449 T2457 punct ",",phosphorylates
R2349 T2637 T2635 conj Lys123,Lys122
R2350 T2638 T2638 ROOT down-regulate,down-regulate
R2351 T2639 T2641 det the,activity
R2352 T2640 T2641 compound NF-κB,activity
R2353 T2641 T2638 dobj activity,down-regulate
R2354 T2450 T2453 det the,kinase
R2355 T2642 T2641 punct (,activity
R2356 T2643 T2641 appos "12,21,22",activity
R2357 T2644 T2641 punct ),activity
R2358 T2451 T2453 amod activated,kinase
R2359 T2645 T2638 punct .,down-regulate
R2360 T2646 T2647 amod Persistent,activation
R2361 T2647 T2650 nsubj activation,occurs
R2362 T2452 T2453 compound IκB,kinase
R2363 T2648 T2647 prep of,activation
R2364 T2649 T2648 pobj NF-κB,of
R2365 T2453 T2457 nsubj kinase,phosphorylates
R2366 T2650 T2650 ROOT occurs,occurs
R2367 T2454 T2455 punct (,IKK
R2368 T2651 T2650 prep in,occurs
R2369 T2652 T2653 amod human,immunodeficiency
R2370 T2653 T2651 pobj immunodeficiency,in
R2371 T2455 T2453 appos IKK,kinase
R2372 T2654 T2656 amod virus-1,HIV-1
R2373 T2655 T2656 punct (,HIV-1
R2374 T2656 T2650 npadvmod HIV-1,occurs
R2375 T2456 T2453 punct ),kinase
R2376 T2657 T2656 punct ),HIV-1
R2377 T2658 T2659 punct -,infected
R2378 T2659 T2660 amod infected,monocytes
R2379 T2457 T2457 ROOT phosphorylates,phosphorylates
R2380 T2660 T2650 conj monocytes,occurs
R2381 T2661 T2660 punct ",",monocytes
R2382 T2662 T2660 conj macrophages,monocytes
R2383 T2458 T2457 dobj IκB,phosphorylates
R2384 T2663 T2662 cc and,macrophages
R2385 T2664 T2662 conj microglia,macrophages
R2386 T2665 T2650 punct ",",occurs
R2387 T2459 T2457 prep at,phosphorylates
R2388 T2666 T2650 cc and,occurs
R2389 T2667 T2650 conj enhances,occurs
R2390 T2460 T2462 amod specific,residues
R2391 T2461 T2462 compound serine,residues
R2392 T2462 T2459 pobj residues,at
R2393 T2668 T2669 det the,expression
R2394 T2463 T2464 nsubj that,target
R2395 T2669 T2667 dobj expression,enhances
R2396 T2670 T2669 prep of,expression
R2397 T2671 T2672 amod NF-κB-responsive,genes
R2398 T2464 T2462 relcl target,residues
R2399 T2672 T2670 pobj genes,of
R2400 T2673 T2672 punct ",",genes
R2401 T2674 T2672 prep including,genes
R2402 T2675 T2676 amod pro-inflammatory,cytokines
R2403 T2676 T2674 pobj cytokines,including
R2404 T2677 T2676 punct ",",cytokines
R2405 T2465 T2466 det the,protein
R2406 T2678 T2679 compound cell,adhesion
R2407 T2679 T2680 compound adhesion,molecules
R2408 T2680 T2676 conj molecules,cytokines
R2409 T2681 T2680 cc and,molecules
R2410 T2466 T2464 dobj protein,target
R2411 T2682 T2680 conj chemokines,molecules
R2412 T2683 T2682 punct (,chemokines
R2413 T2467 T2468 aux to,ubiquitination
R2414 T2684 T2685 nummod 23,25
R2415 T2685 T2682 appos 25,chemokines
R2416 T2686 T2682 punct ),chemokines
R2417 T2468 T2464 advcl ubiquitination,target
R2418 T2687 T2650 punct .,occurs
R2419 T2688 T2689 amod Chronic,inflammation
R2420 T2689 T2690 nsubj inflammation,is
R2421 T2469 T2468 cc and,ubiquitination
R2422 T2690 T2690 ROOT is,is
R2423 T2691 T2693 det a,cause
R2424 T2692 T2693 amod major,cause
R2425 T2470 T2471 amod proteasomal,degradation
R2426 T2693 T2690 attr cause,is
R2427 T2694 T2693 prep of,cause
R2428 T2695 T2698 amod immune,dysfunction
R2429 T2471 T2468 conj degradation,ubiquitination
R2430 T2696 T2695 cc and,immune
R2431 T2697 T2695 conj neuron,immune
R2432 T2698 T2694 pobj dysfunction,of
R2433 T2472 T2471 punct ",",degradation
R2434 T2699 T2698 prep in,dysfunction
R2435 T2700 T2699 pobj AIDS,in
R2436 T2701 T2702 punct (,"26,27"
R2437 T2473 T2474 nsubj which,releases
R2438 T2702 T2698 appos "26,27",dysfunction
R2439 T2703 T2690 punct ),is
R2440 T2765 T2764 prep of,binding
R2441 T2704 T2690 punct .,is
R2442 T2705 T2709 advmod Consistently,hosts
R2443 T2706 T2709 punct ",",hosts
R2444 T2766 T2769 det the,envelope
R2445 T2707 T2709 amod non-human,hosts
R2446 T2708 T2709 compound primate,hosts
R2447 T2709 T2709 ROOT hosts,hosts
R2448 T2767 T2769 nmod gp120,envelope
R2449 T2710 T2709 prep for,hosts
R2450 T2711 T2713 amod simian,virus
R2451 T2712 T2713 compound immunodeficiency,virus
R2452 T2713 T2710 pobj virus,for
R2453 T2768 T2769 amod viral,envelope
R2454 T2714 T2709 punct ",",hosts
R2455 T2715 T2716 amod such,as
R2456 T2716 T2709 prep as,hosts
R2457 T2717 T2719 amod African,monkeys
R2458 T2769 T2765 pobj envelope,of
R2459 T2718 T2719 amod green,monkeys
R2460 T2719 T2716 pobj monkeys,as
R2461 T2720 T2719 cc and,monkeys
R2462 T2721 T2722 amod sooty,mangabey
R2463 T2770 T2772 advmod to,induces
R2464 T2722 T2719 conj mangabey,monkeys
R2465 T2723 T2709 punct ",",hosts
R2466 T2724 T2709 conj lack,hosts
R2467 T2771 T2772 nsubj CD4,induces
R2468 T2725 T2727 amod aberrant,activation
R2469 T2726 T2727 amod immune,activation
R2470 T2727 T2724 dobj activation,lack
R2471 T2728 T2724 cc and,lack
R2472 T2772 T2772 ROOT induces,induces
R2473 T2773 T2775 det the,activity
R2475 T2774 T2775 amod NF-κB,activity
R2479 T2775 T2772 dobj activity,induces
R2483 T2776 T2775 prep by,activity
R2486 T2777 T2776 pobj activation,by
R2489 T2778 T2777 prep of,activation
R2490 T2779 T2778 pobj IKK,of
R2492 T2741 T2752 advmod Thus,provide
R2493 T2780 T2779 punct (,IKK
R2494 T2742 T2752 punct ",",provide
R2495 T2743 T2752 csubj understanding,provide
R2496 T2781 T2779 appos 30,IKK
R2497 T2744 T2745 det the,mechanisms
R2498 T2745 T2743 dobj mechanisms,understanding
R2499 T2746 T2745 prep of,mechanisms
R2500 T2782 T2779 punct ),IKK
R2501 T2747 T2748 amod NF-κB,deregulation
R2502 T2748 T2746 pobj deregulation,of
R2503 T2749 T2745 prep by,mechanisms
R2504 T2750 T2749 pobj HIV-1,by
R2505 T2751 T2752 aux may,provide
R2506 T2752 T2752 ROOT provide,provide
R2507 T2783 T2777 cc and,activation
R2508 T2753 T2754 amod further,insights
R2509 T2754 T2752 dobj insights,provide
R2510 T2755 T2752 prep into,provide
R2511 T2784 T2777 conj procaspase,activation
R2512 T2756 T2757 compound AIDS,pathogenesis
R2513 T2757 T2755 pobj pathogenesis,into
R2514 T2758 T2752 punct .,provide
R2515 T2785 T2784 nummod 8,procaspase
R2516 T2759 T2772 prep In,induces
R2517 T2760 T2761 compound HIV-1,entry
R2518 T2761 T2759 pobj entry,In
R2519 T2762 T2772 punct ",",induces
R2520 T2786 T2787 punct (,31
R2521 T2763 T2764 det the,binding
R2522 T2764 T2772 nsubj binding,induces
R2523 T2787 T2784 npadvmod 31,procaspase
R2524 T2788 T2772 punct ),induces
R2525 T2789 T2772 punct .,induces
R2526 T2790 T2800 prep Following,interacts
R2527 T2830 T2829 punct ",",transcripts
R2528 T2831 T2829 prep including,transcripts
R2529 T2791 T2792 amod viral,integration
R2530 T2832 T2835 det the,element
R2531 T2833 T2835 nmod HIV-1,element
R2532 T2792 T2790 pobj integration,Following
R2533 T2834 T2835 amod transactivation-responsive,element
R2534 T2835 T2831 pobj element,including
R2535 T2836 T2835 punct (,element
R2536 T2837 T2835 appos TAR,element
R2537 T2793 T2800 punct ",",interacts
R2538 T2838 T2835 punct ),element
R2539 T2839 T2835 punct (,element
R2540 T2794 T2799 det the,protein
R2541 T2840 T2835 appos 32,element
R2542 T2841 T2835 punct ),element
R2543 T2842 T2835 punct ",",element
R2544 T2795 T2799 amod early,protein
R2545 T2843 T2844 compound tumor,necrosis
R2546 T2844 T2845 compound necrosis,factor
R2547 T2796 T2799 amod encoded,protein
R2548 T2845 T2846 compound factor,β
R2549 T2846 T2835 appos β,element
R2550 T2847 T2846 punct (,β
R2551 T2797 T2798 compound HIV-1,Tat
R2552 T2848 T2846 appos TNFβ,β
R2553 T2849 T2846 punct ),β
R2554 T2850 T2846 punct (,β
R2555 T2851 T2846 appos 33,β
R2556 T2852 T2846 punct ),β
R2557 T2798 T2799 compound Tat,protein
R2558 T2853 T2846 cc and,β
R2559 T2854 T2846 conj interleukin-6,β
R2560 T2799 T2800 nsubj protein,interacts
R2561 T2855 T2856 punct (,IL-6
R2562 T2856 T2854 appos IL-6,interleukin-6
R2563 T2857 T2854 punct ),interleukin-6
R2564 T2800 T2800 ROOT interacts,interacts
R2565 T2858 T2854 punct (,interleukin-6
R2566 T2859 T2854 appos 34,interleukin-6
R2567 T2860 T2854 punct ),interleukin-6
R2568 T2801 T2800 prep with,interacts
R2569 T2861 T2862 aux to,activate
R2570 T2802 T2804 det the,RNA
R2571 T2803 T2804 compound HIV-1,RNA
R2572 T2862 T2835 relcl activate,element
R2573 T2804 T2801 pobj RNA,with
R2574 T2863 T2864 compound gene,transcription
R2575 T2864 T2862 dobj transcription,activate
R2576 T2865 T2816 punct .,binds
R2577 T2805 T2804 cc and,RNA
R2578 T2866 T2869 advmod Indeed,promotes
R2579 T2867 T2869 punct ",",promotes
R2580 T2868 T2869 nsubj Tat,promotes
R2581 T2806 T2807 compound host,cell
R2582 T2869 T2869 ROOT promotes,promotes
R2583 T2870 T2872 det the,initiation
R2584 T2871 T2872 amod transcriptional,initiation
R2585 T2807 T2808 compound cell,factors
R2586 T2872 T2869 dobj initiation,promotes
R2587 T2873 T2872 cc and,initiation
R2588 T2874 T2872 conj elongation,initiation
R2589 T2808 T2804 conj factors,RNA
R2590 T2875 T2869 prep by,promotes
R2591 T2876 T2875 pcomp interacting,by
R2592 T2877 T2876 prep with,interacting
R2593 T2878 T2879 amod transacting,factors
R2594 T2809 T2810 aux to,sustain
R2595 T2879 T2877 pobj factors,with
R2596 T2880 T2879 cc and,factors
R2597 T2881 T2879 conj cofactors,factors
R2598 T2810 T2800 xcomp sustain,interacts
R2599 T2882 T2881 punct ",",cofactors
R2600 T2883 T2884 amod such,as
R2601 T2884 T2879 prep as,factors
R2602 T2885 T2884 pobj Sp1,as
R2603 T2886 T2885 punct (,Sp1
R2604 T2811 T2813 det the,replication
R2605 T2812 T2813 amod viral,replication
R2609 T2813 T2810 dobj replication,sustain
R2613 T2814 T2800 punct .,interacts
R2616 T2815 T2816 nsubj Tat,binds
R2619 T2816 T2816 ROOT binds,binds
R2621 T2817 T2816 prep to,binds
R2625 T2818 T2817 pobj RNA,to
R2629 T2819 T2820 amod stem-loop,structures
R2633 T2820 T2818 dobj structures,RNA
R2634 T2907 T2906 nummod T1/CDK9,cyclin
R2635 T2908 T2909 punct (,"39,40"
R2636 T2909 T2906 appos "39,40",cyclin
R2637 T2821 T2820 acl generated,structures
R2638 T2910 T2906 punct ),cyclin
R2639 T2911 T2906 cc and,cyclin
R2640 T2912 T2913 det the,histone
R2641 T2822 T2821 agent by,generated
R2642 T2913 T2906 conj histone,cyclin
R2643 T2914 T2869 conj acetyltransferases,promotes
R2644 T2915 T2914 appos p300/CBP,acetyltransferases
R2645 T2916 T2915 cc and,p300/CBP
R2646 T2823 T2826 det the,end
R2647 T2917 T2915 conj P/CAF,p300/CBP
R2648 T2918 T2917 punct (,P/CAF
R2649 T2919 T2917 appos 41,P/CAF
R2650 T2920 T2917 appos 43,P/CAF
R2651 T2824 T2825 nummod 5,′
R2652 T2921 T2917 punct ),P/CAF
R2653 T2922 T2869 punct .,promotes
R2654 T2923 T2924 advmod When,released
R2655 T2924 T2930 advcl released,deregulates
R2656 T2925 T2924 prep from,released
R2657 T2926 T2927 amod HIV-1-infected,cells
R2658 T2825 T2826 compound ′,end
R2659 T2927 T2925 pobj cells,from
R2660 T2928 T2930 punct ",",deregulates
R2661 T2929 T2930 nsubj Tat,deregulates
R2662 T2826 T2822 pobj end,by
R2663 T2930 T2930 ROOT deregulates,deregulates
R2664 T2931 T2932 det the,cell
R2665 T2932 T2930 dobj cell,deregulates
R2666 T2827 T2826 prep of,end
R2667 T2933 T2932 acl signaling,cell
R2668 T2934 T2933 prep by,signaling
R2669 T2935 T2934 pcomp binding,by
R2670 T2936 T2935 prep to,binding
R2671 T2828 T2829 compound target,transcripts
R2672 T2937 T2938 compound cell,receptors
R2673 T2938 T2936 pobj receptors,to
R2674 T2939 T2938 punct ",",receptors
R2675 T2829 T2827 pobj transcripts,of
R2676 T2940 T2941 amod such,as
R2677 T2941 T2938 prep as,receptors
R2678 T2942 T2941 pobj integrins,as
R2679 T2943 T2942 punct (,integrins
R2680 T2959 T2961 nsubj We,reported
R2681 T2944 T2942 appos 44,integrins
R2682 T2945 T2942 punct ),integrins
R2683 T2946 T2938 punct ",",receptors
R2684 T2947 T2948 compound Flk1/KDR,receptor
R2685 T2960 T2961 advmod first,reported
R2686 T2948 T2938 appos receptor,receptors
R2687 T2949 T2948 punct (,receptor
R2688 T2950 T2948 appos 45,receptor
R2689 T2951 T2948 punct ),receptor
R2690 T2961 T2961 ROOT reported,reported
R2691 T2952 T2948 cc and,receptor
R2692 T2953 T2954 amod chemokine,receptors
R2693 T2954 T2948 conj receptors,receptor
R2694 T2962 T2964 mark that,was
R2695 T2955 T2954 punct (,receptors
R2696 T2956 T2954 appos 46,receptors
R2697 T2957 T2954 punct ),receptors
R2698 T2958 T2930 punct .,deregulates
R2699 T2963 T2964 nsubj NF-κB,was
R2700 T2964 T2961 ccomp was,reported
R2701 T2965 T2966 advmod constitutively,active
R2702 T2966 T2964 acomp active,was
R2703 T3056 T3055 pobj IκB-α,of
R2704 T3057 T3058 punct (,"15,17"
R2705 T3058 T3056 parataxis "15,17",IκB-α
R2706 T2967 T2966 prep in,active
R2707 T3059 T3040 punct ),subvert
R2708 T3060 T3035 punct .,was
R2709 T3061 T3063 nsubj We,found
R2710 T2968 T2969 compound Jurkat,cells
R2711 T3062 T3063 advmod previously,found
R2712 T3063 T3063 ROOT found,found
R2713 T3064 T3070 mark that,promotes
R2714 T2969 T2967 pobj cells,in
R2715 T3065 T3066 amod IκB-α,binds
R2716 T3066 T3070 nsubj binds,promotes
R2717 T3067 T3066 prep to,binds
R2718 T2970 T2972 nsubj that,expressed
R2719 T3068 T3067 pobj Tat,to
R2720 T3069 T3066 cc and,binds
R2721 T3070 T3063 ccomp promotes,found
R2722 T2971 T2972 advmod stably,expressed
R2723 T3071 T3073 det the,export
R2724 T3072 T3073 amod nuclear,export
R2725 T2972 T2961 ccomp expressed,reported
R2726 T3073 T3070 dobj export,promotes
R2727 T3074 T3073 prep of,export
R2728 T3075 T3077 det the,transactivator
R2729 T3076 T3077 amod viral,transactivator
R2730 T2973 T2975 det the,gene
R2731 T3077 T3074 pobj transactivator,of
R2732 T3078 T3077 punct (,transactivator
R2733 T3079 T3077 appos "50,51",transactivator
R2734 T2974 T2975 compound Tat,gene
R2735 T3080 T3077 punct ),transactivator
R2736 T3081 T3063 punct .,found
R2737 T3082 T3087 prep In,report
R2738 T3083 T3084 det this,study
R2739 T3084 T3082 pobj study,In
R2740 T3085 T3087 punct ",",report
R2741 T3086 T3087 nsubj we,report
R2742 T3087 T3087 ROOT report,report
R2743 T2975 T2972 dobj gene,expressed
R2744 T3088 T3090 mark that,counteracts
R2745 T3089 T3090 nsubj Tat,counteracts
R2746 T3090 T3087 ccomp counteracts,report
R2747 T2976 T2975 punct (,gene
R2748 T3091 T3093 det the,turn
R2749 T3092 T3093 amod post-activation,turn
R2750 T3093 T3090 dobj turn,counteracts
R2751 T2977 T2975 appos 47,gene
R2752 T3094 T3093 prt off,turn
R2753 T3095 T3093 prep of,turn
R2754 T3096 T3095 pobj NF-κB,of
R2755 T3097 T3090 prep through,counteracts
R2756 T3098 T3099 amod direct,interaction
R2757 T2978 T2975 punct ),gene
R2758 T3099 T3097 pobj interaction,through
R2759 T3100 T3099 prep with,interaction
R2760 T3101 T3100 pobj IκB-α,with
R2761 T3102 T3101 cc and,IκB-α
R2762 T2979 T2961 punct .,reported
R2763 T3103 T3101 conj p65,IκB-α
R2764 T3104 T3101 punct ",",IκB-α
R2765 T3105 T3106 nsubj which,enhances
R2766 T2980 T2988 prep Following,induced
R2767 T3106 T3101 relcl enhances,IκB-α
R2768 T3107 T3108 det the,DNA
R2769 T3108 T3106 dobj DNA,enhances
R2770 T2981 T2982 compound gene,transfection
R2771 T2982 T2980 pobj transfection,Following
R2772 T3109 T3112 amod binding,activity
R2773 T2983 T2982 cc or,transfection
R2774 T3110 T3109 cc and,binding
R2775 T3111 T3109 conj transcriptional,binding
R2776 T3112 T3106 dobj activity,enhances
R2777 T2984 T2985 compound protein,transduction
R2778 T3113 T3112 prep of,activity
R2779 T3114 T3116 det the,complex
R2780 T3115 T3116 compound NF-κB,complex
R2781 T3116 T3113 pobj complex,of
R2782 T2985 T2982 conj transduction,transfection
R2783 T3117 T3087 punct .,report
R2784 T3118 T3120 det The,mechanism
R2785 T3119 T3120 amod new,mechanism
R2786 T2986 T2988 punct ",",induced
R2787 T3120 T3125 nsubj mechanism,described
R2788 T3121 T3120 prep of,mechanism
R2789 T2987 T2988 nsubj Tat,induced
R2790 T3122 T3123 amod NF-κB,deregulation
R2791 T2988 T2988 ROOT induced,induced
R2792 T3123 T3121 pobj deregulation,of
R2793 T3124 T3120 advmod here,mechanism
R2794 T3125 T3125 ROOT described,described
R2795 T2989 T2991 det the,activity
R2796 T3126 T3127 aux may,provide
R2797 T3127 T3125 ccomp provide,described
R2798 T2990 T2991 compound IKK,activity
R2799 T3128 T3129 amod further,insights
R2800 T3129 T3127 dobj insights,provide
R2801 T3130 T3129 prep into,insights
R2802 T2991 T2988 dobj activity,induced
R2803 T3131 T3134 det the,activation
R2804 T3132 T3134 amod chronic,activation
R2805 T3133 T3134 amod immune,activation
R2806 T3134 T3130 pobj activation,into
R2807 T3135 T3134 prep of,activation
R2808 T3136 T3137 amod HIV-1,infection
R2809 T2992 T2991 cc and,activity
R2810 T3137 T3135 pobj infection,of
R2811 T3138 T3125 punct .,described
R2812 T2993 T2994 amod proteasomal,degradation
R2813 T2994 T2991 conj degradation,activity
R2814 T2995 T2994 prep of,degradation
R2815 T2996 T2995 pobj IκB-α,of
R2816 T2997 T2996 punct (,IκB-α
R2817 T2998 T2996 appos 48,IκB-α
R2818 T2999 T2996 punct ),IκB-α
R2819 T3000 T2988 punct ",",induced
R2820 T3001 T2988 cc and,induced
R2821 T3002 T2988 conj increased,induced
R2822 T3003 T3006 det the,activity
R2823 T3004 T3006 nmod p65,activity
R2824 T3005 T3006 compound transcriptional,activity
R2825 T3006 T3002 dobj activity,increased
R2826 T3007 T3002 prep by,increased
R2827 T3008 T3007 pcomp inhibiting,by
R2828 T3009 T3011 det the,deacetylation
R2829 T3010 T3011 amod SIRT-1-mediated,deacetylation
R2830 T3011 T3008 dobj deacetylation,inhibiting
R2831 T3012 T3011 prep of,deacetylation
R2832 T3013 T3014 compound p65,Lys310
R2833 T3014 T3012 pobj Lys310,of
R2834 T3015 T3014 punct (,Lys310
R2835 T3016 T3014 appos 49,Lys310
R2836 T3017 T3014 punct ),Lys310
R2837 T3018 T2988 punct .,induced
R2838 T3019 T3020 det These,findings
R2839 T3020 T3021 nsubj findings,suggested
R2840 T3021 T3035 ccomp suggested,was
R2841 T3022 T3024 mark that,modulates
R2842 T3023 T3024 nsubj Tat,modulates
R2843 T3024 T3021 ccomp modulates,suggested
R2844 T3025 T3026 amod crucial,enzymes
R2845 T3026 T3024 dobj enzymes,modulates
R2846 T3027 T3026 acl involved,enzymes
R2847 T3028 T3027 prep in,involved
R2848 T3029 T3030 amod NF-κB,signaling
R2849 T3030 T3024 prep signaling,modulates
R2850 T3031 T3035 punct ;,was
R2851 T3032 T3035 advmod however,was
R2852 T3033 T3035 punct ",",was
R2853 T3034 T3035 nsubj it,was
R2854 T3035 T3035 ROOT was,was
R2855 T3036 T3035 acomp unclear,was
R2856 T3037 T3040 advmod how,subvert
R2857 T3038 T3040 nsubj Tat,subvert
R2858 T3039 T3040 aux could,subvert
R2859 T3040 T3035 ccomp subvert,was
R2860 T3041 T3043 det the,feedback
R2861 T3042 T3043 amod negative,feedback
R2871 T3052 T3054 nmod de,synthesis
R2872 T3053 T3054 amod novo,synthesis
R2873 T3054 T3051 pobj synthesis,on
R2874 T3055 T3054 prep of,synthesis
R4150 T4596 T4596 ROOT Plasmids,Plasmids
R4151 T4597 T4599 det The,pcDNA-3xHA-IκB-α
R4152 T4598 T4599 compound plasmids,pcDNA-3xHA-IκB-α
R4153 T4599 T4596 appos pcDNA-3xHA-IκB-α,Plasmids
R4154 T4600 T4599 punct ",",pcDNA-3xHA-IκB-α
R4155 T4601 T4599 conj p3xFLAG-CMV-Tat,pcDNA-3xHA-IκB-α
R4156 T4602 T4601 punct ",",p3xFLAG-CMV-Tat
R4157 T4603 T4604 compound p3xFLAG-CMV-Tat,C
R4158 T4604 T4599 appos C,pcDNA-3xHA-IκB-α
R4159 T4605 T4604 punct (,C
R4160 T4606 T4604 appos "22,25,27",C
R4161 T4607 T4604 punct ),C
R4162 T4608 T4604 appos A,C
R4163 T4609 T4611 punct ",",R
R4164 T4610 T4611 amod p3xFLAG-CMV-Tat,R
R4165 T4611 T4604 appos R,C
R4166 T4612 T4611 punct (,R
R4167 T4613 T4611 appos "49,52,53,55,56,57",R
R4168 T4614 T4611 punct ),R
R4169 T4615 T4620 det A,C
R4170 T4616 T4617 punct ",",pGEX-2T-Tat
R4171 T4617 T4620 nmod pGEX-2T-Tat,C
R4172 T4618 T4620 punct ",",C
R4173 T4619 T4620 compound pGEX-2T-Tat,C
R4174 T4620 T4620 ROOT C,C
R4175 T4621 T4620 punct (,C
R4176 T4622 T4620 appos "22,25,27",C
R4177 T4623 T4620 punct ),C
R4178 T4624 T4624 ROOT A,A
R4179 T4625 T4624 cc and,A
R4180 T4626 T4627 amod pGEX-2T-Tat,R
R4181 T4627 T4624 conj R,A
R4182 T4628 T4627 punct (,R
R4183 T4629 T4627 appos "49,52,53,55,56,57",R
R4184 T4630 T4627 punct ),R
R4185 T4631 T4634 nsubjpass A,described
R4186 T4632 T4634 auxpass were,described
R4187 T4633 T4634 advmod previously,described
R4188 T4634 T4634 ROOT described,described
R4189 T4635 T4634 punct (,described
R4190 T4636 T4634 npadvmod 50,described
R4191 T4637 T4634 punct ),described
R4192 T4638 T4634 punct .,described
R4193 T4639 T4641 det The,pNL4-3
R4194 T4640 T4641 compound plasmids,pNL4-3
R4195 T4641 T4648 nsubjpass pNL4-3,obtained
R4196 T4642 T4641 punct .,pNL4-3
R4197 T4643 T4648 punct Luc.R-E,obtained
R4198 T4644 T4643 punct -,Luc.R-E
R4199 T4645 T4643 cc and,Luc.R-E
R4200 T4646 T4643 conj pHXB2-env,Luc.R-E
R4201 T4647 T4648 auxpass were,obtained
R4202 T4648 T4672 ccomp obtained,purchased
R4203 T4649 T4648 prep from,obtained
R4204 T4650 T4656 det the,Program
R4205 T4651 T4652 compound AIDS,Research
R4206 T4652 T4656 nmod Research,Program
R4207 T4653 T4652 cc &,Research
R4208 T4654 T4652 conj Reference,Research
R4209 T4655 T4656 compound Reagent,Program
R4210 T4656 T4649 pobj Program,from
R4212 T4658 T4656 conj Division,Program
R4213 T4659 T4658 prep of,Division
R4214 T4660 T4659 pobj AIDS,of
R4215 T4661 T4658 punct ",",Division
R4216 T4662 T4658 conj NIAID,Division
R4217 T4663 T4662 punct ",",NIAID
R4224 T4670 T4668 conj pSV-β-Gal,pκBluc
R4225 T4671 T4672 auxpass were,purchased
R4226 T4672 T4672 ROOT purchased,purchased
R4227 T4673 T4672 prep from,purchased
R4228 T4674 T4673 pobj Promega,from
R4229 T4675 T4676 punct (,Madison
R4230 T4676 T4674 appos Madison,Promega
R4231 T4677 T4676 punct ",",Madison
R4232 T4678 T4676 conj WI,Madison
R4233 T4679 T4678 punct ",",WI
R4234 T4680 T4678 npadvmod USA,WI
R4235 T4681 T4678 punct ),WI
R4236 T4682 T4672 punct .,purchased
R4237 T4683 T4687 det The,xHA-p65
R4238 T4684 T4685 compound plasmids,pRc/CMV
R4239 T4685 T4687 nmod pRc/CMV,xHA-p65
R4240 T4686 T4687 nummod -3,xHA-p65
R4241 T4687 T4687 ROOT xHA-p65,xHA-p65
R4242 T4688 T4687 punct ",",xHA-p65
R4243 T4689 T4687 appos pRc/CMV,xHA-p65
R4244 T4690 T4691 nummod -3,xHA-p65ΔC
R4245 T4691 T4687 appos xHA-p65ΔC,xHA-p65
R4246 T4692 T4693 punct (,1
R4247 T4693 T4699 nummod 1,xHA-p65ΔN
R4248 T4694 T4693 appos 318,1
R4249 T4695 T4693 punct ),1
R4250 T4696 T4693 punct ",",1
R4251 T4697 T4699 nmod pRc/CMV,xHA-p65ΔN
R4252 T4698 T4699 nummod -3,xHA-p65ΔN
R4253 T4699 T4691 appos xHA-p65ΔN,xHA-p65ΔC
R4254 T4700 T4699 punct (,xHA-p65ΔN
R4255 T4701 T4699 parataxis 122,xHA-p65ΔN
R4256 T4702 T4701 prep 551,122
R4257 T4703 T4701 punct ),122
R4258 T4704 T4706 punct ",",T
R4259 T4705 T4706 compound p3xFLAG-CMV-Tat,T
R4260 T4706 T4699 conj T,xHA-p65ΔN
R4261 T4707 T4706 punct ",",T
R4262 T4708 T4706 npadvmod N,T
R4263 T4709 T4710 punct (,"23,24"
R4264 T4710 T4708 parataxis "23,24",N
R4265 T4711 T4710 punct ),"23,24"
R4266 T4712 T4715 det A,K
R4267 T4713 T4715 punct ",",K
R4268 T4714 T4715 compound p3xFLAG-CMV-Tat,K
R4269 T4715 T4715 ROOT K,K
R4270 T4716 T4715 punct (,K
R4271 T4717 T4715 appos "50,51",K
R4272 T4718 T4715 punct ),K
R4273 T4719 T4722 det A,T
R4274 T4720 T4722 punct ",",T
R4275 T4721 T4722 compound pGEX-2T-Tat,T
R4276 T4722 T4722 ROOT T,T
R4277 T4723 T4722 punct ",",T
R4278 T4724 T4722 conj N,T
R4279 T4725 T4724 punct (,N
R4280 T4726 T4724 appos "23,24",N
R4281 T4727 T4724 punct ),N
R4282 T4728 T4728 ROOT A,A
R4283 T4729 T4735 punct ",",A
R4284 T4730 T4731 amod pGEX-2T-Tat,K
R4285 T4731 T4735 nmod K,A
R4286 T4732 T4731 punct (,K
R4287 T4733 T4731 appos "50,51",K
R4288 T4734 T4735 punct ),A
R4289 T4735 T4728 det A,A
R4290 T4736 T4735 cc and,A
R4291 T4737 T4735 conj pNL4-3,A
R4292 T4738 T4737 punct .,pNL4-3
R4293 T4739 T4739 ROOT FLAG-Tat,FLAG-Tat
R4294 T4740 T4739 punct .,FLAG-Tat
R4295 T4741 T4744 nsubjpass R-E,generated
R4296 T4742 T4744 punct -,generated
R4297 T4743 T4744 auxpass were,generated
R4298 T4744 T4744 ROOT generated,generated
R4299 T4745 T4746 mark as,described
R4300 T4746 T4744 advcl described,generated
R4301 T4747 T4746 prep in,described
R4302 T4748 T4749 compound Supplementary,Data
R4303 T4749 T4747 pobj Data,in
R4304 T4750 T4744 punct .,generated
R4581 T5199 T5207 nmod Cells,HeLa
R4582 T5200 T5199 punct ",",Cells
R4583 T5201 T5199 conj transfection,Cells
R4584 T5202 T5201 punct ",",transfection
R4585 T5203 T5201 conj treatments,transfection
R4586 T5204 T5203 cc and,treatments
R4587 T5205 T5206 compound luciferase,assay
R4588 T5206 T5203 conj assay,treatments
R4589 T5207 T5230 nsubjpass HeLa,cultured
R4590 T5208 T5207 punct ",",HeLa
R4591 T5209 T5219 nummod p50,fibroblasts
R4592 T5210 T5219 nmod −,fibroblasts
R4593 T5211 T5219 nmod /,fibroblasts
R4594 T5212 T5219 nmod −,fibroblasts
R4595 T5213 T5219 nmod p65,fibroblasts
R4596 T5214 T5219 nmod −,fibroblasts
R4597 T5215 T5219 nmod /,fibroblasts
R4598 T5216 T5219 nmod −,fibroblasts
R4599 T5217 T5219 nmod mouse,fibroblasts
R4600 T5218 T5219 amod embryonic,fibroblasts
R4601 T5219 T5207 appos fibroblasts,HeLa
R4602 T5220 T5219 punct (,fibroblasts
R4603 T5221 T5219 appos MEFs,fibroblasts
R4604 T5222 T5219 punct ),fibroblasts
R4605 T5223 T5219 punct (,fibroblasts
R4606 T5224 T5219 appos 52,fibroblasts
R4607 T5225 T5219 punct ),fibroblasts
R4608 T5226 T5219 cc and,fibroblasts
R4609 T5227 T5228 amod 293T,cells
R4610 T5228 T5219 conj cells,fibroblasts
R4611 T5229 T5230 auxpass were,cultured
R4612 T5230 T5253 ccomp cultured,cultured
R4613 T5231 T5230 prep in,cultured
R4614 T5232 T5237 poss Dulbecco,medium
R4615 T5233 T5232 case 's,Dulbecco
R4616 T5234 T5237 amod modified,medium
R4617 T5235 T5237 poss Eagle,medium
R4618 T5236 T5235 case 's,Eagle
R4619 T5237 T5231 pobj medium,in
R4620 T5238 T5253 punct ;,cultured
R4621 T5239 T5253 nsubjpass Jurkat,cultured
R4622 T5240 T5239 punct ",",Jurkat
R4623 T5241 T5242 compound U937,cells
R4624 T5242 T5239 appos cells,Jurkat
R4625 T5243 T5242 cc and,cells
R4626 T5244 T5246 amod human,blood
R4627 T5245 T5246 compound peripheral,blood
R4628 T5246 T5248 compound blood,cells
R4629 T5247 T5248 compound mononuclear,cells
R4630 T5248 T5242 conj cells,cells
R4631 T5249 T5250 punct (,PBMCs
R4632 T5250 T5248 appos PBMCs,cells
R4633 T5251 T5248 punct ),cells
R4634 T5252 T5253 auxpass were,cultured
R4635 T5253 T5253 ROOT cultured,cultured
R4636 T5254 T5253 prep in,cultured
R4637 T5255 T5254 pobj RPMI,in
R4638 T5256 T5255 nummod 1640,RPMI
R4639 T5257 T5253 punct .,cultured
R4640 T5258 T5260 nsubjpass PBMCs,isolated
R4641 T5259 T5260 auxpass were,isolated
R4642 T5260 T5260 ROOT isolated,isolated
R4643 T5261 T5263 mark as,described
R4644 T5262 T5263 advmod previously,described
R4645 T5263 T5260 advcl described,isolated
R4646 T5264 T5263 punct (,described
R4647 T5265 T5263 npadvmod 53,described
R4648 T5266 T5263 punct ),described
R4649 T5267 T5260 punct .,isolated
R4650 T5268 T5270 nsubjpass Media,supplemented
R4651 T5269 T5270 auxpass were,supplemented
R4652 T5270 T5270 ROOT supplemented,supplemented
R4653 T5271 T5270 prep with,supplemented
R4654 T5272 T5273 nummod 10,%
R4655 T5273 T5277 nmod %,serum
R4656 T5274 T5277 amod heat-inactivated,serum
R4657 T5275 T5276 amod fetal,calf
R4658 T5276 T5277 compound calf,serum
R4659 T5277 T5271 pobj serum,with
R4660 T5278 T5277 cc and,serum
R4661 T5279 T5280 nummod 2,mM
R4662 T5280 T5281 compound mM,l-glutamine
R4663 T5281 T5277 conj l-glutamine,serum
R4664 T5282 T5285 punct (,AG
R4665 T5283 T5285 compound Lonza,AG
R4666 T5284 T5285 compound Cologne,AG
R4667 T5285 T5277 appos AG,serum
R4668 T5286 T5285 punct ",",AG
R4669 T5287 T5285 npadvmod Germany,AG
R4670 T5288 T5285 punct ),AG
R4671 T5289 T5270 punct .,supplemented
R4672 T5290 T5304 nsubjpass HeLa,transfected
R4673 T5291 T5290 punct ",",HeLa
R4674 T5292 T5300 nummod p50,MEFs
R4675 T5293 T5299 nmod −,−
R4676 T5294 T5299 nmod /,−
R4677 T5295 T5299 nmod −,−
R4678 T5296 T5299 nmod p65,−
R4679 T5297 T5299 nmod −,−
R4680 T5298 T5299 nmod /,−
R4681 T5299 T5300 nmod −,MEFs
R4682 T5300 T5290 conj MEFs,HeLa
R4683 T5301 T5300 cc and,MEFs
R4684 T5302 T5300 conj 293T,MEFs
R4685 T5303 T5304 auxpass were,transfected
R4686 T5304 T5332 ccomp transfected,equalized
R4687 T5305 T5304 prep with,transfected
R4688 T5306 T5305 pobj DNA,with
R4689 T5307 T5304 prep by,transfected
R4690 T5308 T5307 pcomp using,by
R4691 T5309 T5310 compound FuGENE,HD
R4692 T5310 T5308 dobj HD,using
R4693 T5311 T5314 punct (,GmbH
R4694 T5312 T5314 compound Roche,GmbH
R4695 T5313 T5314 compound Diagnostic,GmbH
R4696 T5314 T5308 dobj GmbH,using
R4697 T5315 T5314 punct ",",GmbH
R4698 T5316 T5314 conj Mannheim,GmbH
R4699 T5317 T5316 punct ",",Mannheim
R4700 T5318 T5314 npadvmod Germany,GmbH
R4701 T5319 T5314 punct ),GmbH
R4702 T5320 T5304 punct ",",transfected
R4703 T5321 T5304 prep according,transfected
R4704 T5322 T5321 prep to,according
R4705 T5323 T5324 det the,manufacturer
R4706 T5324 T5326 poss manufacturer,protocol
R4707 T5325 T5324 case 's,manufacturer
R4708 T5326 T5322 pobj protocol,to
R4709 T5327 T5332 punct ;,equalized
R4710 T5328 T5330 amod total,amounts
R4711 T5329 T5330 compound DNA,amounts
R4712 T5330 T5332 nsubjpass amounts,equalized
R4713 T5331 T5332 auxpass were,equalized
R4714 T5332 T5332 ROOT equalized,equalized
R4715 T5333 T5332 agent by,equalized
R4716 T5334 T5333 pobj transfection,by
R4717 T5335 T5334 prep of,transfection
R4718 T5336 T5338 nmod pRc/CMV,vector
R4719 T5337 T5338 amod empty,vector
R4720 T5338 T5335 pobj vector,of
R4721 T5339 T5340 punct (,Invitrogen
R4722 T5340 T5338 appos Invitrogen,vector
R4723 T5341 T5340 punct ",",Invitrogen
R4724 T5342 T5340 npadvmod Carlsbad,Invitrogen
R4725 T5343 T5342 punct ",",Carlsbad
R4726 T5344 T5342 conj CA,Carlsbad
R4727 T5345 T5344 punct ",",CA
R4728 T5346 T5344 conj USA,CA
R4729 T5347 T5340 punct ),Invitrogen
R4730 T5348 T5332 punct .,equalized
R4731 T5349 T5355 prep For,treated
R4732 T5350 T5349 pobj pulse-stimulation,For
R4733 T5351 T5355 punct ",",treated
R4734 T5352 T5353 compound HeLa,cells
R4735 T5353 T5355 nsubjpass cells,treated
R4736 T5354 T5355 auxpass were,treated
R4737 T5355 T5397 ccomp treated,washed
R4738 T5356 T5355 prep with,treated
R4739 T5357 T5359 nmod phorbol,13-acetate
R4740 T5358 T5359 amod 12-myristate,13-acetate
R4741 T5359 T5356 pobj 13-acetate,with
R4742 T5360 T5359 punct (,13-acetate
R4743 T5361 T5359 appos PMA,13-acetate
R4744 T5362 T5397 punct ;,washed
R4745 T5363 T5397 nsubj Sigma-Aldrich,washed
R4746 T5364 T5363 punct ",",Sigma-Aldrich
R4747 T5365 T5366 compound St,Louis
R4748 T5366 T5363 conj Louis,Sigma-Aldrich
R4749 T5367 T5366 punct ",",Louis
R4750 T5368 T5366 conj MO,Louis
R4751 T5369 T5368 punct ",",MO
R4752 T5370 T5368 conj USA,MO
R4753 T5371 T5363 punct ),Sigma-Aldrich
R4754 T5372 T5374 punct (,ng/ml
R4755 T5373 T5374 nummod 20,ng/ml
R4756 T5374 T5363 appos ng/ml,Sigma-Aldrich
R4757 T5375 T5363 punct ),Sigma-Aldrich
R4758 T5376 T5363 prep for,Sigma-Aldrich
R4759 T5377 T5378 nummod 5,min
R4760 T5378 T5376 pobj min,for
R4761 T5379 T5378 punct ",",min
R4762 T5380 T5378 cc or,min
R4763 T5381 T5382 compound tumor,necrosis
R4764 T5382 T5383 compound necrosis,factor-α
R4765 T5383 T5378 conj factor-α,min
R4766 T5384 T5385 punct (,TNF-α
R4767 T5385 T5383 appos TNF-α,factor-α
R4768 T5386 T5363 punct ;,Sigma-Aldrich
R4769 T5387 T5363 conj Sigma-Aldrich,Sigma-Aldrich
R4770 T5388 T5363 punct ),Sigma-Aldrich
R4771 T5389 T5391 punct (,ng/ml
R4772 T5390 T5391 nummod 20,ng/ml
R4773 T5391 T5363 appos ng/ml,Sigma-Aldrich
R4774 T5392 T5363 punct ),Sigma-Aldrich
R4775 T5393 T5363 prep for,Sigma-Aldrich
R4776 T5394 T5395 nummod 30,min
R4777 T5395 T5393 pobj min,for
R4778 T5396 T5397 punct ",",washed
R4779 T5397 T5397 ROOT washed,washed
R4780 T5398 T5397 advmod twice,washed
R4781 T5399 T5397 prep in,washed
R4782 T5400 T5402 amod complete,medium
R4783 T5401 T5402 compound culture,medium
R4784 T5402 T5399 pobj medium,in
R4785 T5403 T5397 cc and,washed
R4786 T5404 T5405 advmod then,returned
R4787 T5405 T5397 conj returned,washed
R4788 T5406 T5405 prep to,returned
R4789 T5407 T5406 pobj culture,to
R4790 T5408 T5397 punct .,washed
R4791 T5409 T5415 prep For,co-transfected
R4792 T5410 T5411 compound luciferase,assays
R4793 T5411 T5409 pobj assays,For
R4794 T5412 T5415 punct ",",co-transfected
R4795 T5413 T5414 nsubj pSV-β-Gal,was
R4796 T5414 T5415 auxpass was,co-transfected
R4797 T5415 T5415 ROOT co-transfected,co-transfected
R4798 T5416 T5415 prep with,co-transfected
R4799 T5417 T5416 pobj pκBluc,with
R4800 T5418 T5419 aux to,monitor
R4801 T5419 T5415 advcl monitor,co-transfected
R4802 T5420 T5422 det the,efficiency
R4803 T5421 T5422 compound transfection,efficiency
R4804 T5422 T5419 dobj efficiency,monitor
R4805 T5423 T5415 punct .,co-transfected
R4806 T5424 T5425 amod Forty-eight-hour,post-transfection
R4807 T5425 T5429 intj post-transfection,lysed
R4808 T5426 T5429 punct ",",lysed
R4809 T5427 T5429 nsubjpass cells,lysed
R4810 T5428 T5429 auxpass were,lysed
R4811 T5429 T5429 ROOT lysed,lysed
R4812 T5430 T5429 prep in,lysed
R4813 T5431 T5432 compound lysis,buffer
R4814 T5432 T5430 pobj buffer,in
R4815 T5433 T5432 prep of,buffer
R4816 T5434 T5435 compound Dual,Light
R4817 T5435 T5437 compound Light,System
R4818 T5436 T5437 compound Luciferase,System
R4819 T5437 T5433 pobj System,of
R4820 T5438 T5437 punct (,System
R4821 T5439 T5437 appos Tropix,System
R4822 T5440 T5439 punct ",",Tropix
R4823 T5441 T5439 conj Bedford,Tropix
R4824 T5442 T5441 punct ",",Bedford
R4825 T5443 T5441 conj MA,Bedford
R4826 T5444 T5443 punct ",",MA
R4827 T5445 T5443 conj USA,MA
R4828 T5446 T5443 punct ),MA
R4829 T5447 T5437 cc and,System
R4830 T5448 T5449 det the,luciferase
R4831 T5449 T5452 nmod luciferase,activities
R4832 T5450 T5449 cc and,luciferase
R4833 T5451 T5449 conj β-galactosidase,luciferase
R4834 T5452 T5454 nsubjpass activities,evaluated
R4835 T5453 T5454 auxpass were,evaluated
R4836 T5454 T5429 conj evaluated,lysed
R4837 T5455 T5454 prep by,evaluated
R4838 T5456 T5455 pcomp using,by
R4839 T5457 T5458 compound Dual,Light
R4840 T5458 T5460 compound Light,System
R4841 T5459 T5460 compound Luciferase,System
R4842 T5460 T5456 dobj System,using
R4843 T5461 T5460 punct (,System
R4844 T5462 T5460 appos Tropix,System
R4845 T5463 T5460 punct ),System
R4846 T5464 T5456 prep in,using
R4847 T5465 T5466 det a,bioluminometer
R4848 T5466 T5464 pobj bioluminometer,in
R4849 T5467 T5469 punct (,Biosystem
R4850 T5468 T5469 compound Turner,Biosystem
R4851 T5469 T5454 npadvmod Biosystem,evaluated
R4852 T5470 T5469 punct ",",Biosystem
R4853 T5471 T5469 npadvmod Sunnyvale,Biosystem
R4854 T5472 T5471 punct ",",Sunnyvale
R4855 T5473 T5471 conj CA,Sunnyvale
R4856 T5474 T5473 punct ",",CA
R4857 T5475 T5473 conj USA,CA
R4858 T5476 T5473 punct ),CA
R4859 T5477 T5454 punct .,evaluated
R4860 T5478 T5479 det The,ratio
R4861 T5479 T5488 nsubjpass ratio,expressed
R4862 T5480 T5479 prep of,ratio
R4863 T5481 T5483 amod firefly,activity
R4864 T5482 T5483 amod luciferase,activity
R4865 T5483 T5480 pobj activity,of
R4866 T5484 T5483 prep to,activity
R4867 T5485 T5486 amod β-galactosidase,activity
R4868 T5486 T5484 pobj activity,to
R4869 T5487 T5488 auxpass was,expressed
R4870 T5488 T5488 ROOT expressed,expressed
R4871 T5489 T5488 prep as,expressed
R4872 T5490 T5492 amod relative,units
R4873 T5491 T5492 amod light,units
R4874 T5492 T5489 pobj units,as
R4875 T5493 T5488 punct .,expressed
R5028 T5824 T5825 compound RNA,interference
R5029 T5825 T5826 compound interference,Jurkat
R5030 T5826 T5829 nmod Jurkat,cells
R5031 T5827 T5826 cc or,Jurkat
R5032 T5828 T5826 conj U937,Jurkat
R5033 T5829 T5831 nsubjpass cells,transfected
R5034 T5830 T5831 auxpass were,transfected
R5035 T5831 T5831 ROOT transfected,transfected
R5036 T5832 T5831 agent by,transfected
R5037 T5833 T5832 pobj electroporation,by
R5038 T5834 T5831 advcl using,transfected
R5039 T5835 T5837 det a,apparatus
R5040 T5836 T5837 compound Bio-Rad,apparatus
R5041 T5837 T5834 dobj apparatus,using
R5042 T5838 T5837 punct (,apparatus
R5043 T5839 T5840 compound Bio-Rad,Laboratories
R5044 T5840 T5837 appos Laboratories,apparatus
R5045 T5841 T5840 punct ",",Laboratories
R5046 T5842 T5840 conj Hercules,Laboratories
R5047 T5843 T5842 punct ",",Hercules
R5048 T5844 T5842 conj CA,Hercules
R5049 T5845 T5844 punct ",",CA
R5050 T5846 T5844 conj USA,CA
R5051 T5847 T5837 punct ),apparatus
R5052 T5848 T5831 punct .,transfected
R5053 T5849 T5859 advmod Briefly,suspended
R5054 T5850 T5859 punct ",",suspended
R5055 T5851 T5859 nsubjpass aliquots,suspended
R5056 T5852 T5851 punct (,aliquots
R5057 T5853 T5856 nummod 5,cells
R5058 T5854 T5856 nummod ×,cells
R5059 T5855 T5856 nummod 106,cells
R5060 T5856 T5851 appos cells,aliquots
R5061 T5857 T5851 punct ),aliquots
R5062 T5858 T5859 auxpass were,suspended
R5063 T5859 T5859 ROOT suspended,suspended
R5064 T5860 T5859 prep in,suspended
R5065 T5861 T5862 nummod 0.3,ml
R5066 T5862 T5860 pobj ml,in
R5067 T5863 T5862 prep of,ml
R5068 T5864 T5865 compound RPMI,1640
R5069 T5865 T5863 pobj 1640,of
R5070 T5866 T5859 conj supplemented,suspended
R5071 T5867 T5866 prep with,supplemented
R5072 T5868 T5869 nummod 20,%
R5073 T5869 T5872 compound %,serum
R5074 T5870 T5871 amod fetal,calf
R5075 T5871 T5872 compound calf,serum
R5076 T5872 T5867 pobj serum,with
R5077 T5873 T5872 cc and,serum
R5078 T5874 T5859 conj subjected,suspended
R5079 T5875 T5874 prep to,subjected
R5080 T5876 T5879 det a,pulse
R5081 T5877 T5879 amod double,pulse
R5082 T5878 T5879 amod electrical,pulse
R5083 T5879 T5875 pobj pulse,to
R5084 T5880 T5882 punct (,V
R5085 T5881 T5882 nummod 0.22,V
R5086 T5882 T5879 appos V,pulse
R5087 T5883 T5882 punct ",",V
R5088 T5884 T5885 nummod 960,µF
R5089 T5885 T5882 appos µF,V
R5090 T5886 T5885 punct ),µF
R5091 T5887 T5882 prep in,V
R5092 T5888 T5889 det the,presence
R5093 T5889 T5887 pobj presence,in
R5094 T5890 T5889 prep of,presence
R5095 T5891 T5892 compound annealed,siRNA
R5096 T5892 T5890 pobj siRNA,of
R5097 T5893 T5892 punct (,siRNA
R5098 T5894 T5895 nummod 200,pmol
R5099 T5895 T5892 appos pmol,siRNA
R5100 T5896 T5892 punct ),siRNA
R5101 T5897 T5882 punct ;,V
R5102 T5898 T5899 amod electroporated,cells
R5103 T5899 T5901 nsubjpass cells,washed
R5104 T5900 T5901 auxpass were,washed
R5105 T5901 T5859 conj washed,suspended
R5106 T5902 T5901 cc and,washed
R5107 T5903 T5901 conj cultured,washed
R5108 T5904 T5903 prep in,cultured
R5109 T5905 T5906 amod complete,medium
R5110 T5906 T5904 pobj medium,in
R5111 T5907 T5901 punct .,washed
R5112 T5908 T5909 compound RNA,interference
R5113 T5909 T5911 nsubjpass interference,performed
R5114 T5910 T5911 auxpass was,performed
R5115 T5911 T5911 ROOT performed,performed
R5116 T5912 T5911 prep with,performed
R5117 T5913 T5912 punct :,with
R5118 T5914 T5915 compound siRNA,Tat
R5119 T5915 T5916 compound Tat,sense
R5120 T5916 T5912 pobj sense,with
R5121 T5917 T5916 punct ",",sense
R5122 T5918 T5916 conj CUGCUUGUACCAAUUGCUAUU,sense
R5123 T5919 T5918 cc and,CUGCUUGUACCAAUUGCUAUU
R5124 T5920 T5921 compound siRNA,Tat
R5125 T5921 T5918 conj Tat,CUGCUUGUACCAAUUGCUAUU
R5126 T5922 T5918 conj antisense,CUGCUUGUACCAAUUGCUAUU
R5127 T5923 T5922 punct ",",antisense
R5128 T5924 T5922 conj UAGCAAUUGGUACAAGCAGUU,antisense
R5129 T5925 T5928 punct ;,sense
R5130 T5926 T5928 compound siRNA,sense
R5131 T5927 T5928 compound control,sense
R5132 T5928 T5911 npadvmod sense,performed
R5133 T5929 T5928 punct ",",sense
R5135 T5931 T5928 appos AUUGCUAUU,sense
R5136 T5932 T5931 cc and,AUUGCUAUU
R5137 T5933 T5931 conj siRNA,AUUGCUAUU
R5138 T5934 T5935 compound control,antisense
R5139 T5935 T5928 conj antisense,sense
R5140 T5936 T5935 punct ",",antisense
R5141 T5937 T5928 appos UAGCAAUUGUGACAAGCAGUU,sense
R5142 T5938 T5911 punct .,performed
R5143 T5939 T5940 compound RNA,interference
R5144 T5940 T5946 nsubjpass interference,performed
R5145 T5941 T5940 prep of,interference
R5146 T5942 T5941 pobj p65,of
R5147 T5943 T5940 cc and,interference
R5148 T5944 T5940 conj IκB-α,interference
R5149 T5945 T5946 auxpass was,performed
R5150 T5946 T5946 ROOT performed,performed
R5151 T5947 T5946 prep with,performed
R5152 T5948 T5949 compound SMART,pool
R5153 T5949 T5950 compound pool,siRNA
R5154 T5950 T5947 pobj siRNA,with
R5155 T5951 T5950 nummod p65,siRNA
R5156 T5952 T5950 cc and,siRNA
R5157 T5953 T5950 conj IκB-α,siRNA
R5158 T5954 T5955 punct (,Dharmacon
R5159 T5955 T5950 conj Dharmacon,siRNA
R5160 T5956 T5955 punct ",",Dharmacon
R5161 T5957 T5955 npadvmod Chicago,Dharmacon
R5162 T5958 T5955 punct ",",Dharmacon
R5163 T5959 T5955 conj IL,Dharmacon
R5164 T5960 T5959 punct ",",IL
R5165 T5961 T5959 conj USA,IL
R5166 T5962 T5946 punct ),performed
R5167 T5963 T5946 punct .,performed
R5255 T6139 T6140 compound Pseudotyped,virions
R5256 T6140 T6153 nsubjpass virions,transfected
R5257 T6141 T6140 cc and,virions
R5258 T6142 T6146 amod single,cells
R5259 T6143 T6146 amod round,cells
R5260 T6144 T6146 nmod infection,cells
R5261 T6145 T6146 amod 293T,cells
R5262 T6146 T6140 conj cells,virions
R5263 T6147 T6148 punct (,1
R5264 T6148 T6150 nummod 1,107
R5265 T6149 T6150 nummod ×,107
R5266 T6150 T6146 appos 107,cells
R5267 T6151 T6146 punct ),cells
R5268 T6152 T6153 auxpass were,transfected
R5269 T6153 T6153 ROOT transfected,transfected
R5270 T6154 T6153 prep with,transfected
R5271 T6155 T6154 pobj pNL4-3,with
R5272 T6156 T6153 punct .,transfected
R5273 T6157 T6153 punct Luc.R-E,transfected
R5274 T6158 T6157 punct -,Luc.R-E
R5275 T6159 T6157 cc or,Luc.R-E
R5276 T6160 T6157 conj pNL4-3,Luc.R-E
R5277 T6161 T6153 punct .,transfected
R5278 T6162 T6162 ROOT FLAG-Tat,FLAG-Tat
R5279 T6163 T6162 punct .,FLAG-Tat
R5280 T6164 T6162 punct R-E,FLAG-Tat
R5281 T6165 T6164 punct -,R-E
R5282 T6166 T6164 punct (,R-E
R5283 T6167 T6168 nummod 10,µg
R5284 T6168 T6164 appos µg,R-E
R5285 T6169 T6164 punct ),R-E
R5286 T6170 T6171 advmod together,with
R5287 T6171 T6185 prep with,collected
R5288 T6172 T6173 compound pHXB2,Env
R5289 T6173 T6171 pobj Env,with
R5290 T6174 T6176 punct (,µg
R5291 T6175 T6176 nummod 10,µg
R5292 T6176 T6173 appos µg,Env
R5293 T6177 T6176 punct ),µg
R5294 T6178 T6173 punct ",",Env
R5295 T6179 T6173 cc and,Env
R5296 T6180 T6183 amod 48-h,supernatant
R5297 T6181 T6182 amod post-transfection,cell
R5298 T6182 T6183 compound cell,supernatant
R5299 T6183 T6185 nsubjpass supernatant,collected
R5300 T6184 T6185 auxpass was,collected
R5301 T6185 T6185 ROOT collected,collected
R5302 T6186 T6185 punct .,collected
R5303 T6187 T6189 amod Enzyme-linked,assay
R5304 T6188 T6189 compound immunosorbent,assay
R5305 T6189 T6189 ROOT assay,assay
R5306 T6190 T6189 punct (,assay
R5307 T6191 T6189 appos ELISA,assay
R5308 T6192 T6189 punct ),assay
R5309 T6193 T6189 xcomp using,assay
R5310 T6194 T6195 amod anti-p24,antibody
R5311 T6195 T6193 dobj antibody,using
R5312 T6196 T6198 amod measured,concentration
R5313 T6197 T6198 compound virion,concentration
R5314 T6198 T6193 dobj concentration,using
R5315 T6199 T6189 punct .,assay
R5316 T6200 T6212 nsubjpass PBMCs,infected
R5317 T6201 T6200 punct ",",PBMCs
R5318 T6202 T6200 conj Jurkat,PBMCs
R5319 T6203 T6202 cc or,Jurkat
R5320 T6204 T6202 conj U937,Jurkat
R5321 T6205 T6202 conj cells,Jurkat
R5322 T6206 T6205 punct (,cells
R5323 T6207 T6209 quantmod 5,107
R5324 T6208 T6209 quantmod ×,107
R5325 T6209 T6205 appos 107,cells
R5326 T6210 T6205 punct ),cells
R5327 T6211 T6212 auxpass were,infected
R5328 T6212 T6212 ROOT infected,infected
R5329 T6213 T6212 prep with,infected
R5330 T6214 T6216 nmod HXB2,virions
R5331 T6215 T6216 compound Env-pseudotyped,virions
R5332 T6216 T6213 pobj virions,with
R5333 T6217 T6219 punct (,ng
R5334 T6218 T6219 nummod 500,ng
R5335 T6219 T6216 appos ng,virions
R5336 T6220 T6219 prep of,ng
R5337 T6221 T6220 pobj p24,of
R5338 T6222 T6219 punct ),ng
R5339 T6223 T6219 prep by,ng
R5340 T6224 T6223 pobj spinoculation,by
R5341 T6225 T6219 punct ",",ng
R5342 T6226 T6228 mark as,described
R5343 T6227 T6228 advmod previously,described
R5344 T6228 T6219 advcl described,ng
R5345 T6229 T6228 punct (,described
R5346 T6230 T6228 npadvmod 50,described
R5347 T6231 T6219 punct ),ng
R5348 T6232 T6212 punct .,infected
R5358 T6307 T6308 compound Cell,extracts
R5359 T6308 T6326 nsubjpass extracts,performed
R5360 T6309 T6308 punct ",",extracts
R5361 T6310 T6311 amod western,blotting
R5362 T6311 T6326 nsubjpass blotting,performed
R5363 T6312 T6311 punct ",",blotting
R5364 T6313 T6314 compound IKK,activity
R5365 T6314 T6311 conj activity,blotting
R5366 T6315 T6314 cc and,activity
R5367 T6316 T6317 compound NF-κB,DNA
R5368 T6317 T6314 conj DNA,activity
R5369 T6318 T6319 amod binding,Total
R5370 T6319 T6314 conj Total,activity
R5371 T6320 T6319 punct ",",Total
R5372 T6321 T6324 amod nuclear,extracts
R5373 T6322 T6321 cc and,nuclear
R5374 T6323 T6321 conj cytosolic,nuclear
R5375 T6324 T6314 conj extracts,activity
R5376 T6325 T6326 auxpass were,performed
R5377 T6326 T6336 ccomp performed,reported
R5378 T6327 T6329 mark as,described
R5379 T6328 T6329 advmod previously,described
R5380 T6329 T6326 advcl described,performed
R5381 T6330 T6329 punct (,described
R5382 T6331 T6329 npadvmod 54,described
R5383 T6332 T6329 punct ),described
R5384 T6333 T6336 punct ;,reported
R5385 T6334 T6336 nsubjpass details,reported
R5386 T6335 T6336 auxpass are,reported
R5387 T6336 T6336 ROOT reported,reported
R5388 T6337 T6336 prep in,reported
R5389 T6338 T6339 compound Supplementary,Data
R5390 T6339 T6337 pobj Data,in
R5391 T6340 T6336 punct .,reported
R5392 T6341 T6343 amod Western,analysis
R5393 T6342 T6343 amod blotting,analysis
R5394 T6343 T6345 nsubjpass analysis,performed
R5395 T6344 T6345 auxpass was,performed
R5396 T6345 T6345 ROOT performed,performed
R5397 T6346 T6345 agent by,performed
R5398 T6347 T6380 advcl resuspending,resolved
R5399 T6348 T6349 compound protein,aliquots
R5400 T6349 T6347 dobj aliquots,resuspending
R5401 T6350 T6347 prep in,resuspending
R5402 T6351 T6350 pcomp loading,in
R5403 T6352 T6351 dobj buffer,loading
R5404 T6353 T6352 punct (,buffer
R5405 T6354 T6356 nummod 125,Tris
R5406 T6355 T6356 compound mM,Tris
R5407 T6356 T6352 appos Tris,buffer
R5408 T6357 T6380 nsubj HCl,resolved
R5409 T6358 T6357 punct ",",HCl
R5410 T6359 T6357 appos pH,HCl
R5411 T6360 T6359 nummod 6.8,pH
R5412 T6361 T6359 punct ",",pH
R5413 T6362 T6363 nummod 5,%
R5414 T6363 T6364 npadvmod %,SDS
R5415 T6364 T6357 conj SDS,HCl
R5416 T6365 T6364 punct ",",SDS
R5417 T6366 T6367 nummod 1,%
R5418 T6367 T6369 npadvmod %,blue
R5419 T6368 T6369 compound bromophenol,blue
R5420 T6369 T6373 amod blue,β-mercaptoethanol
R5421 T6370 T6373 punct ",",β-mercaptoethanol
R5422 T6371 T6372 nummod 10,%
R5423 T6372 T6373 compound %,β-mercaptoethanol
R5424 T6373 T6364 appos β-mercaptoethanol,SDS
R5425 T6374 T6364 punct ",",SDS
R5426 T6375 T6376 nummod 25,%
R5427 T6376 T6377 compound %,glycerol
R5428 T6377 T6364 appos glycerol,SDS
R5429 T6378 T6364 punct ),SDS
R5430 T6379 T6364 punct ",",SDS
R5431 T6380 T6346 pcomp resolved,by
R5432 T6381 T6380 prep on,resolved
R5433 T6382 T6383 nummod 12,%
R5434 T6383 T6384 compound %,SDS
R5435 T6384 T6381 pobj SDS,on
R5436 T6385 T6384 appos PAGE,SDS
R5437 T6386 T6384 punct ",",SDS
R5438 T6387 T6345 advcl transferred,performed
R5439 T6388 T6389 aux to,polyvinylidene
R5440 T6389 T6387 xcomp polyvinylidene,transferred
R5441 T6390 T6391 compound difluoride,membrane
R5442 T6391 T6389 dobj membrane,polyvinylidene
R5443 T6392 T6393 punct (,Millipore
R5444 T6393 T6391 appos Millipore,membrane
R5445 T6394 T6393 punct ",",Millipore
R5446 T6395 T6393 conj Bedford,Millipore
R5447 T6396 T6395 punct ",",Bedford
R5448 T6397 T6395 conj MA,Bedford
R5449 T6398 T6397 punct ",",MA
R5450 T6399 T6397 conj USA,MA
R5451 T6400 T6397 punct ),MA
R5452 T6401 T6387 cc and,transferred
R5453 T6402 T6387 conj incubated,transferred
R5454 T6403 T6402 prep with,incubated
R5455 T6404 T6405 amod primary,antibodies
R5456 T6405 T6403 pobj antibodies,with
R5457 T6406 T6405 punct (,antibodies
R5458 T6407 T6405 appos 1:1000,antibodies
R5459 T6408 T6405 punct ),antibodies
R5460 T6409 T6387 conj followed,transferred
R5461 T6410 T6409 agent by,followed
R5462 T6411 T6410 pobj incubation,by
R5463 T6412 T6409 prep with,followed
R5464 T6413 T6414 amod horseradish-peroxidase-linked,mouse
R5465 T6414 T6417 nmod mouse,IgG
R5466 T6415 T6414 cc or,mouse
R5467 T6416 T6414 conj rabbit,mouse
R5468 T6417 T6412 pobj IgG,with
R5469 T6418 T6417 punct (,IgG
R5470 T6419 T6417 appos 1:2000,IgG
R5471 T6420 T6417 punct ),IgG
R5472 T6421 T6424 punct (,Amersham
R5473 T6422 T6424 compound GE,Amersham
R5474 T6423 T6424 compound Healthcare,Amersham
R5475 T6424 T6417 appos Amersham,IgG
R5476 T6425 T6424 punct ",",Amersham
R5477 T6426 T6427 compound Little,Chalfont
R5478 T6427 T6424 npadvmod Chalfont,Amersham
R5479 T6428 T6427 punct ",",Chalfont
R5480 T6429 T6427 conj Buckinghamshire,Chalfont
R5481 T6430 T6429 punct ",",Buckinghamshire
R5482 T6431 T6429 appos UK,Buckinghamshire
R5483 T6432 T6429 punct ),Buckinghamshire
R5484 T6433 T6424 prep in,Amersham
R5485 T6434 T6433 pobj PBS,in
R5486 T6435 T6417 acl containing,IgG
R5487 T6436 T6437 nummod 5,%
R5488 T6437 T6440 nmod %,milk
R5489 T6438 T6440 amod non-fat,milk
R5490 T6439 T6440 amod dry,milk
R5491 T6440 T6435 dobj milk,containing
R5492 T6441 T6443 punct (,Laboratories
R5493 T6442 T6443 compound Bio-Rad,Laboratories
R5494 T6443 T6440 appos Laboratories,milk
R5495 T6444 T6440 punct ),milk
R5496 T6445 T6345 punct .,performed
R5497 T6446 T6448 nsubjpass Proteins,detected
R5498 T6447 T6448 auxpass were,detected
R5499 T6448 T6448 ROOT detected,detected
R5500 T6449 T6448 agent by,detected
R5501 T6450 T6449 pobj chemiluminescence,by
R5502 T6451 T6448 advcl using,detected
R5503 T6452 T6454 det the,System
R5504 T6453 T6454 compound ECL,System
R5505 T6454 T6451 dobj System,using
R5506 T6455 T6454 punct (,System
R5507 T6456 T6458 compound GE,Amersham
R5508 T6457 T6458 compound Healthcare,Amersham
R5509 T6458 T6454 appos Amersham,System
R5510 T6459 T6454 punct ),System
R5511 T6460 T6448 punct .,detected
R5512 T6461 T6462 amod Primary,antibodies
R5513 T6462 T6464 nsubjpass antibodies,purchased
R5514 T6463 T6464 auxpass were,purchased
R5515 T6464 T6464 ROOT purchased,purchased
R5516 T6465 T6464 prep from,purchased
R5517 T6466 T6465 punct :,from
R5518 T6467 T6469 compound Santa,Biotechnology
R5519 T6468 T6469 compound Cruz,Biotechnology
R5520 T6469 T6465 pobj Biotechnology,from
R5521 T6470 T6469 punct ",",Biotechnology
R5522 T6471 T6472 compound Santa,Cruz
R5523 T6472 T6469 conj Cruz,Biotechnology
R5524 T6473 T6472 punct ",",Cruz
R5525 T6474 T6472 conj CA,Cruz
R5526 T6475 T6474 punct ",",CA
R5527 T6476 T6474 conj USA,CA
R5528 T6477 T6479 punct (,F7
R5529 T6478 T6479 compound anti-HA,F7
R5530 T6479 T6474 conj F7,CA
R5531 T6480 T6479 punct ",",F7
R5532 T6481 T6482 compound anti-IκB-α,C15
R5533 T6482 T6479 conj C15,F7
R5534 T6483 T6482 punct ",",C15
R5535 T6484 T6485 compound anti-Histone,H1
R5536 T6485 T6482 conj H1,C15
R5537 T6486 T6485 punct ",",H1
R5538 T6487 T6485 conj anti-Hexokinase-II,H1
R5539 T6488 T6479 punct ),F7
R5540 T6489 T6464 punct ;,purchased
R5541 T6490 T6490 ROOT Sigma-Aldrich,Sigma-Aldrich
R5542 T6491 T6493 punct (,M2
R5543 T6492 T6493 amod anti-FLAG,M2
R5544 T6493 T6490 appos M2,Sigma-Aldrich
R5545 T6494 T6493 punct ",",M2
R5546 T6495 T6493 amod anti-γ-Tubulin,M2
R5547 T6496 T6490 punct ),Sigma-Aldrich
R5548 T6497 T6490 punct ;,Sigma-Aldrich
R5549 T6498 T6490 conj Upstate,Sigma-Aldrich
R5550 T6499 T6498 punct ",",Upstate
R5551 T6500 T6501 compound Lake,Placid
R5552 T6501 T6498 conj Placid,Upstate
R5553 T6502 T6501 punct ",",Placid
R5554 T6503 T6501 conj NY,Placid
R5555 T6504 T6503 punct ",",NY
R5556 T6505 T6503 conj USA,NY
R5557 T6506 T6507 punct (,anti-p65
R5558 T6507 T6490 appos anti-p65,Sigma-Aldrich
R5559 T6508 T6507 punct ),anti-p65
R5560 T6509 T6490 punct .,Sigma-Aldrich
R5561 T6510 T6515 nsubjpass Densitometry,analysed
R5562 T6511 T6510 prep of,Densitometry
R5563 T6512 T6513 amod single,bands
R5564 T6513 T6511 pobj bands,of
R5565 T6514 T6515 auxpass was,analysed
R5566 T6515 T6515 ROOT analysed,analysed
R5567 T6516 T6515 agent by,analysed
R5568 T6517 T6519 compound ImageJ,package
R5569 T6518 T6519 compound software,package
R5570 T6519 T6516 pobj package,by
R5571 T6520 T6521 punct (,NIH
R5572 T6521 T6519 amod NIH,package
R5573 T6522 T6521 punct ",",NIH
R5574 T6523 T6521 appos USA,NIH
R5575 T6524 T6521 punct ),NIH
R5576 T6525 T6515 punct .,analysed
R5577 T6526 T6527 compound IKK,activity
R5578 T6527 T6529 nsubjpass activity,evaluated
R5579 T6528 T6529 auxpass was,evaluated
R5580 T6529 T6529 ROOT evaluated,evaluated
R5581 T6530 T6529 prep in,evaluated
R5582 T6531 T6532 amod cytosolic,extracts
R5583 T6532 T6530 pobj extracts,in
R5584 T6533 T6529 advcl using,evaluated
R5585 T6534 T6539 det the,kit
R5586 T6535 T6539 compound HTScan,kit
R5587 T6536 T6539 compound IKK,kit
R5588 T6537 T6538 compound kinase,assay
R5589 T6538 T6539 compound assay,kit
R5590 T6539 T6533 dobj kit,using
R5591 T6540 T6539 punct (,kit
R5592 T6541 T6543 compound Cell,Technology
R5593 T6542 T6543 compound Signaling,Technology
R5594 T6543 T6539 appos Technology,kit
R5595 T6544 T6543 punct ",",Technology
R5597 T6546 T6545 punct ",",Danvers
R5598 T6547 T6545 conj MA,Danvers
R5599 T6548 T6547 punct ",",MA
R5600 T6549 T6547 conj USA,MA
R5601 T6550 T6543 punct ),Technology
R5602 T6551 T6529 punct .,evaluated
R5603 T6552 T6565 nsubjpass Binding,measured
R5604 T6553 T6552 prep of,Binding
R5605 T6554 T6553 pobj p65,of
R5606 T6555 T6552 punct ",",Binding
R5607 T6556 T6552 appos p50,Binding
R5608 T6557 T6556 cc and,p50
R5609 T6558 T6556 conj FLAG-Tat,p50
R5610 T6559 T6552 prep to,Binding
R5611 T6560 T6563 det the,oligonucleotide
R5612 T6561 T6563 amod double-stranded,oligonucleotide
R5613 T6562 T6563 compound NF-κB,oligonucleotide
R5614 T6563 T6559 pobj oligonucleotide,to
R5615 T6564 T6565 auxpass was,measured
R5616 T6565 T6565 ROOT measured,measured
R5617 T6566 T6565 advcl using,measured
R5618 T6567 T6568 compound NF-κB,Combo
R5619 T6568 T6572 compound Combo,kit
R5620 T6569 T6572 compound Transcription,kit
R5621 T6570 T6572 compound Factor,kit
R5622 T6571 T6572 compound Assay,kit
R5623 T6572 T6566 dobj kit,using
R5624 T6573 T6576 punct (,Company
R5625 T6574 T6576 compound Cayman,Company
R5626 T6575 T6576 compound Chemical,Company
R5627 T6576 T6566 parataxis Company,using
R5628 T6577 T6576 punct ",",Company
R5629 T6578 T6579 compound Ann,Arbor
R5630 T6579 T6576 conj Arbor,Company
R5631 T6580 T6579 punct ",",Arbor
R5632 T6581 T6579 conj MI,Arbor
R5633 T6582 T6581 punct ",",MI
R5634 T6583 T6581 conj USA,MI
R5635 T6584 T6576 punct ),Company
R5636 T6585 T6565 punct .,measured
R5637 T6586 T6589 compound Electrophoretic,Assay
R5638 T6587 T6588 compound Mobility,Shift
R5639 T6588 T6589 compound Shift,Assay
R5640 T6589 T6594 nsubjpass Assay,performed
R5641 T6590 T6591 punct (,EMSA
R5642 T6591 T6589 appos EMSA,Assay
R5643 T6592 T6589 punct ),Assay
R5644 T6593 T6594 auxpass was,performed
R5645 T6594 T6604 ccomp performed,described
R5646 T6595 T6597 mark as,described
R5647 T6596 T6597 advmod previously,described
R5648 T6597 T6594 advcl described,performed
R5649 T6598 T6597 punct (,described
R5650 T6599 T6597 npadvmod 55,described
R5651 T6600 T6597 punct ),described
R5652 T6601 T6604 punct ;,described
R5653 T6602 T6604 nsubjpass details,described
R5654 T6603 T6604 auxpass are,described
R5655 T6604 T6604 ROOT described,described
R5656 T6605 T6604 prep in,described
R5657 T6606 T6607 compound Supplementary,Data
R5658 T6607 T6605 pobj Data,in
R5659 T6608 T6604 punct .,described
R5748 T6765 T6774 prep In,expressed
R5749 T6766 T6767 amod vitro,translation
R5750 T6767 T6765 pobj translation,In
R5751 T6768 T6774 nsubjpass HA-IκB-α,expressed
R5752 T6769 T6768 punct ",",HA-IκB-α
R5753 T6770 T6768 conj p65,HA-IκB-α
R5754 T6771 T6770 cc and,p65
R5755 T6772 T6770 conj Tat,p65
R5756 T6773 T6774 auxpass were,expressed
R5757 T6774 T6774 ROOT expressed,expressed
R5758 T6775 T6774 prep under,expressed
R5759 T6776 T6778 det the,promoter
R5760 T6777 T6778 nummod T7,promoter
R5761 T6778 T6775 pobj promoter,under
R5762 T6779 T6775 cc and,under
R5763 T6780 T6775 conj in,under
R5764 T6781 T6782 amod vitro,translated
R5765 T6782 T6774 conj translated,expressed
R5766 T6783 T6782 advcl using,translated
R5767 T6784 T6789 det the,system
R5768 T6785 T6789 nmod TnT,system
R5769 T6786 T6789 amod quick,system
R5770 T6787 T6789 amod coupled,system
R5771 T6788 T6789 compound transcription/translation,system
R5772 T6789 T6783 dobj system,using
R5773 T6790 T6789 punct (,system
R5774 T6791 T6789 appos Promega,system
R5775 T6792 T6789 punct ),system
R5776 T6793 T6783 punct ",",using
R5777 T6794 T6796 mark as,reported
R5778 T6795 T6796 advmod previously,reported
R5779 T6796 T6783 advcl reported,using
R5780 T6797 T6783 punct (,using
R5781 T6798 T6783 npadvmod 50,using
R5782 T6799 T6783 punct ),using
R5783 T6800 T6774 punct .,expressed
R5784 T6801 T6803 nsubjpass Details,described
R5785 T6802 T6803 auxpass are,described
R5786 T6803 T6803 ROOT described,described
R5787 T6804 T6803 prep in,described
R5788 T6805 T6806 compound Supplementary,Data
R5789 T6806 T6804 pobj Data,in
R5790 T6807 T6803 punct .,described
R5860 T6916 T6917 compound Immunoprecipitation,assay
R5861 T6917 T6934 nsubj assay,strain
R5862 T6918 T6917 cc and,assay
R5863 T6919 T6917 conj GST-pull,assay
R5864 T6920 T6919 prt down,GST-pull
R5865 T6921 T6919 conj Immunoprecipitation,GST-pull
R5866 T6922 T6921 punct ",",Immunoprecipitation
R5867 T6923 T6921 conj GST-pull,Immunoprecipitation
R5868 T6924 T6917 advmod down,assay
R5869 T6925 T6917 punct ",",assay
R5870 T6926 T6917 cc and,assay
R5871 T6927 T6917 conj production,assay
R5872 T6928 T6917 prep of,assay
R5873 T6929 T6930 compound GST,proteins
R5874 T6930 T6928 pobj proteins,of
R5875 T6931 T6917 prep in,assay
R5876 T6932 T6933 compound Escherichia,coli
R5877 T6933 T6931 pobj coli,in
R5878 T6934 T6934 ROOT strain,strain
R5879 T6935 T6937 nsubjpass BL21,performed
R5880 T6936 T6937 auxpass were,performed
R5881 T6937 T6934 ccomp performed,strain
R5882 T6938 T6940 mark as,reported
R5883 T6939 T6940 advmod previously,reported
R5884 T6940 T6937 advcl reported,performed
R5885 T6941 T6940 punct (,reported
R5886 T6942 T6940 npadvmod 50,reported
R5887 T6943 T6940 punct ),reported
R5888 T6944 T6934 punct .,strain
R5889 T6945 T6947 nsubjpass Details,described
R5890 T6946 T6947 auxpass are,described
R5891 T6947 T6947 ROOT described,described
R5892 T6948 T6947 prep in,described
R5893 T6949 T6950 compound Supplementary,Data
R5894 T6950 T6948 pobj Data,in
R5895 T6951 T6947 punct .,described
R6071 T7201 T7204 amod Real-time,RNA
R6072 T7202 T7204 compound PCR,RNA
R6073 T7203 T7204 compound Total,RNA
R6074 T7204 T7206 nsubjpass RNA,extracted
R6075 T7205 T7206 auxpass was,extracted
R6076 T7206 T7226 ccomp extracted,transcribed
R6077 T7207 T7206 prep from,extracted
R6078 T7208 T7207 pobj cells,from
R6079 T7209 T7206 prep by,extracted
R6080 T7210 T7209 pcomp using,by
R6081 T7211 T7213 det the,reagent
R6082 T7212 T7213 compound TRIzol,reagent
R6083 T7213 T7210 dobj reagent,using
R6084 T7214 T7213 punct (,reagent
R6085 T7215 T7213 appos Invitrogen,reagent
R6086 T7216 T7213 punct ),reagent
R6087 T7217 T7226 punct ;,transcribed
R6088 T7218 T7219 compound RNA,aliquots
R6089 T7219 T7226 nsubjpass aliquots,transcribed
R6090 T7220 T7219 punct (,aliquots
R6091 T7221 T7222 nummod 200,ng
R6092 T7222 T7219 appos ng,aliquots
R6093 T7223 T7219 punct ),aliquots
R6094 T7224 T7226 auxpass were,transcribed
R6095 T7225 T7226 advmod reverse,transcribed
R6096 T7226 T7226 ROOT transcribed,transcribed
R6097 T7227 T7226 advcl using,transcribed
R6098 T7228 T7229 compound Random,Examers
R6099 T7229 T7227 dobj Examers,using
R6100 T7230 T7229 punct (,Examers
R6101 T7231 T7229 appos Roche,Examers
R6102 T7232 T7229 punct ),Examers
R6103 T7233 T7229 cc and,Examers
R6104 T7234 T7235 compound Superscript,III
R6105 T7235 T7229 conj III,Examers
R6106 T7236 T7227 xcomp Reverse,using
R6107 T7237 T7236 npadvmod Transcriptase,Reverse
R6108 T7238 T7237 punct (,Transcriptase
R6109 T7239 T7237 appos Invitrogen,Transcriptase
R6110 T7240 T7237 punct ),Transcriptase
R6111 T7241 T7236 punct ",",Reverse
R6112 T7242 T7226 prep according,transcribed
R6113 T7243 T7242 prep to,according
R6114 T7244 T7245 det the,manufacturer
R6115 T7245 T7247 poss manufacturer,protocol
R6116 T7246 T7245 case 's,manufacturer
R6117 T7247 T7243 pobj protocol,to
R6118 T7248 T7226 punct .,transcribed
R6119 T7249 T7250 compound Real-time,PCR
R6120 T7250 T7252 nsubjpass PCR,performed
R6121 T7251 T7252 auxpass was,performed
R6122 T7252 T7252 ROOT performed,performed
R6123 T7253 T7252 prep with,performed
R6124 T7254 T7258 det the,mix
R6125 T7255 T7257 compound iQ,Super
R6126 T7256 T7257 compound Green,Super
R6127 T7257 T7258 compound Super,mix
R6128 T7258 T7253 pobj mix,with
R6129 T7259 T7261 punct (,Laboratories
R6161 T7291 T7292 compound °,C
R6162 T7292 T7284 appos C,C
R6163 T7293 T7292 punct ",",C
R6164 T7294 T7295 nsubj 10,s
R6165 T7295 T7292 appos s,C
R6166 T7296 T7292 punct ;,C
R6167 T7297 T7298 nummod 60,°
R6168 T7298 T7299 compound °,C
R6169 T7299 T7292 conj C,C
R6170 T7300 T7299 punct ",",C
R6171 T7301 T7302 nummod 30,s
R6172 T7302 T7299 appos s,C
R6173 T7303 T7299 punct ),C
R6174 T7304 T7305 advmod ×,40
R6175 T7305 T7292 appos 40,C
R6176 T7306 T7252 punct .,performed
R6177 T7307 T7313 nsubjpass Primers,listed
R6178 T7308 T7307 prep for,Primers
R6179 T7309 T7308 pobj Tat,for
R6180 T7310 T7309 cc and,Tat
R6181 T7311 T7309 conj MIP-1α,Tat
R6182 T7312 T7313 auxpass are,listed
R6183 T7313 T7313 ROOT listed,listed
R6184 T7314 T7313 prep in,listed
R6185 T7315 T7316 compound Supplementary,Data
R6186 T7316 T7314 pobj Data,in
R6187 T7317 T7313 punct .,listed
R6188 T7318 T7319 amod Real-time,PCR
R6189 T7319 T7333 nsubjpass PCR,performed
R6190 T7320 T7319 prep of,PCR
R6191 T7321 T7320 pobj CSF3,of
R6192 T7322 T7321 punct ",",CSF3
R6193 T7323 T7321 conj LTA,CSF3
R6194 T7324 T7323 punct ",",LTA
R6195 T7325 T7323 conj NFKBIA,LTA
R6196 T7326 T7325 punct ",",NFKBIA
R6197 T7327 T7325 conj TLR2,NFKBIA
R6198 T7328 T7327 punct ",",TLR2
R6199 T7329 T7327 conj GAPDH,TLR2
R6200 T7330 T7329 cc and,GAPDH
R6201 T7331 T7329 conj ACTB,GAPDH
R6202 T7332 T7333 auxpass was,performed
R6203 T7333 T7333 ROOT performed,performed
R6204 T7334 T7333 advcl using,performed
R6205 T7335 T7337 det the,profiler
R6206 T7336 T7337 compound RT2,profiler
R6207 T7337 T7342 nmod profiler,pathway
R6208 T7338 T7340 compound PCR,NF-κB
R6209 T7339 T7340 compound Array-Human,NF-κB
R6210 T7340 T7337 appos NF-κB,profiler
R6211 T7341 T7342 compound signaling,pathway
R6212 T7342 T7334 dobj pathway,using
R6213 T7343 T7342 punct (,pathway
R6214 T7344 T7345 compound QIAGEN,Sciences
R6215 T7345 T7342 appos Sciences,pathway
R6216 T7346 T7345 punct ",",Sciences
R6217 T7347 T7345 conj MD,Sciences
R6218 T7348 T7345 punct ",",Sciences
R6219 T7349 T7345 appos USA,Sciences
R6220 T7350 T7342 punct ),pathway
R6221 T7351 T7333 punct .,performed
R6222 T7352 T7354 nsubjpass Reactions,carried
R6223 T7353 T7354 auxpass were,carried
R6224 T7354 T7354 ROOT carried,carried
R6225 T7355 T7354 prt out,carried
R6226 T7356 T7354 prep in,carried
R6227 T7357 T7356 pobj triplicate,in
R6228 T7358 T7354 punct ",",carried
R6229 T7359 T7354 cc and,carried
R6230 T7360 T7361 compound gene,expression
R6231 T7361 T7362 compound expression,levels
R6232 T7362 T7364 nsubjpass levels,calculated
R6233 T7363 T7364 auxpass were,calculated
R6234 T7364 T7354 conj calculated,carried
R6235 T7365 T7364 oprd relative,calculated
R6236 T7366 T7365 prep to,relative
R6237 T7367 T7369 compound GAPDH,levels
R6238 T7368 T7369 compound mRNA,levels
R6239 T7369 T7366 pobj levels,to
R6240 T7370 T7365 prep as,relative
R6241 T7371 T7372 amod endogenous,control
R6242 T7372 T7370 pobj control,as
R6243 T7373 T7364 punct .,calculated
R6244 T7374 T7375 amod Relative,expression
R6245 T7375 T7377 nsubjpass expression,calculated
R6246 T7376 T7377 auxpass was,calculated
R6247 T7377 T7377 ROOT calculated,calculated
R6248 T7378 T7377 prep as,calculated
R6249 T7379 T7382 nummod 2,gene
R6250 T7380 T7382 punct (,gene
R6251 T7381 T7382 compound Ct,gene
R6252 T7382 T7378 pobj gene,as
R6253 T7383 T7382 prep under,gene
R6254 T7384 T7383 pobj investigation,under
R6255 T7385 T7387 compound −,GAPDH
R6256 T7386 T7387 compound Ct,GAPDH
R6257 T7387 T7382 appos GAPDH,gene
R6258 T7388 T7382 punct ),gene
R6259 T7389 T7377 punct .,calculated
R6267 T7546 T7549 amod Chromatin,Cells
R6268 T7547 T7549 compound immunoprecipitation,Cells
R6269 T7548 T7549 compound assay,Cells
R6270 T7549 T7551 nsubjpass Cells,fixed
R6271 T7550 T7551 auxpass were,fixed
R6272 T7551 T7551 ROOT fixed,fixed
R6273 T7552 T7551 prep by,fixed
R6274 T7553 T7552 pcomp adding,by
R6275 T7554 T7553 dobj formaldehyde,adding
R6276 T7555 T7556 punct (,Sigma-Aldrich
R6277 T7556 T7554 appos Sigma-Aldrich,formaldehyde
R6278 T7557 T7556 punct ),Sigma-Aldrich
R6279 T7558 T7553 prep at,adding
R6280 T7559 T7561 det the,concentration
R6281 T7560 T7561 amod final,concentration
R6282 T7561 T7558 pobj concentration,at
R6283 T7562 T7561 prep of,concentration
R6284 T7563 T7564 nummod 1,%
R6285 T7564 T7562 pobj %,of
R6286 T7565 T7551 punct .,fixed
R6287 T7566 T7577 prep After,added
R6288 T7567 T7568 nummod 10,min
R6289 T7568 T7566 pobj min,After
R6290 T7569 T7577 punct ",",added
R6291 T7570 T7571 amod ice-cold,PBS
R6292 T7571 T7577 nsubjpass PBS,added
R6293 T7572 T7571 cc plus,PBS
R6294 T7573 T7575 nummod 0.125,glycine
R6295 T7574 T7575 compound M,glycine
R6296 T7575 T7571 conj glycine,PBS
R6297 T7576 T7577 auxpass was,added
R6298 T7577 T7577 ROOT added,added
R6299 T7578 T7577 punct ",",added
R6300 T7579 T7577 cc and,added
R6301 T7580 T7582 nsubjpass plates,transferred
R6302 T7581 T7582 auxpass were,transferred
R6303 T7582 T7577 conj transferred,added
R6304 T7583 T7582 prep on,transferred
R6305 T7584 T7583 pobj ice,on
R6306 T7585 T7582 punct ",",transferred
R6307 T7586 T7582 conj washed,transferred
R6308 T7587 T7586 advmod extensively,washed
R6309 T7588 T7586 prep with,washed
R6310 T7589 T7588 pobj PBS,with
R6311 T7590 T7586 punct ",",washed
R6312 T7591 T7586 cc and,washed
R6313 T7592 T7586 conj scraped,washed
R6314 T7593 T7577 punct .,added
R6315 T7594 T7598 prep After,were
R6316 T7595 T7594 pobj centrifugation,After
R6317 T7596 T7598 punct ",",were
R6318 T7597 T7598 nsubj cells,were
R6319 T7598 T7620 ccomp were,supplemented
R6320 T7599 T7600 nummod 10,min
R6321 T7600 T7598 attr min,were
R6322 T7601 T7600 amod lysed,min
R6323 T7602 T7601 prep in,lysed
R6324 T7603 T7604 compound lysis,buffer
R6325 T7604 T7602 pobj buffer,in
R6326 T7605 T7620 punct (,supplemented
R6327 T7606 T7620 punct 5,supplemented
R6328 T7607 T7609 compound mM,pH
R6329 T7608 T7609 compound PIPES,pH
R6330 T7609 T7620 nsubj pH,supplemented
R6331 T7610 T7609 nummod 8.0,pH
R6332 T7611 T7609 punct ",",pH
R6333 T7612 T7614 nummod 85,KCl
R6334 T7613 T7614 compound mM,KCl
R6335 T7614 T7609 conj KCl,pH
R6336 T7615 T7614 punct ",",KCl
R6337 T7616 T7617 nummod 0.5,%
R6338 T7617 T7618 compound %,NP-40
R6339 T7618 T7614 appos NP-40,KCl
R6340 T7619 T7620 punct ),supplemented
R6341 T7620 T7620 ROOT supplemented,supplemented
R6342 T7621 T7620 prep with,supplemented
R6343 T7622 T7623 nummod 1,×
R6344 T7623 T7626 nummod ×,Inhibitor
R6345 T7624 T7626 amod Complete,Inhibitor
R6346 T7625 T7626 compound Protease,Inhibitor
R6347 T7626 T7621 pobj Inhibitor,with
R6348 T7627 T7630 punct (,GmbH
R6349 T7628 T7630 compound Roche,GmbH
R6350 T7629 T7630 compound Diagnostic,GmbH
R6351 T7630 T7626 appos GmbH,Inhibitor
R6352 T7631 T7630 punct ),GmbH
R6353 T7632 T7620 punct .,supplemented
R6354 T7633 T7635 nsubjpass Nuclei,pelletted
R6355 T7634 T7635 auxpass were,pelletted
R6356 T7635 T7635 ROOT pelletted,pelletted
R6357 T7636 T7635 punct (,pelletted
R6358 T7637 T7638 nummod 1000,×
R6359 T7638 T7639 compound ×,g
R6360 T7639 T7644 dep g,","
R6361 T7640 T7642 punct ",",min
R6362 T7641 T7642 nummod 5,min
R6363 T7642 T7639 appos min,g
R6364 T7643 T7639 punct ),g
R6365 T7644 T7635 punct ",",pelletted
R6366 T7645 T7635 cc and,pelletted
R6367 T7646 T7635 conj resuspended,pelletted
R6368 T7647 T7646 prep in,resuspended
R6369 T7648 T7649 compound sonication,buffer
R6370 T7649 T7647 pobj buffer,in
R6371 T7650 T7653 punct (,Tris
R6372 T7651 T7653 nummod 50,Tris
R6373 T7652 T7653 compound mM,Tris
R6374 T7653 T7646 dep Tris,resuspended
R6375 T7654 T7655 compound HCl,pH
R6376 T7655 T7653 appos pH,Tris
R6377 T7656 T7655 nummod 8.0,pH
R6378 T7657 T7655 punct ",",pH
R6379 T7658 T7659 nummod 1,%
R6380 T7659 T7660 compound %,SDS
R6381 T7660 T7655 appos SDS,pH
R6382 T7661 T7660 punct ",",SDS
R6383 T7662 T7664 nummod 10,EDTA
R6384 T7663 T7664 compound mM,EDTA
R6385 T7664 T7660 appos EDTA,SDS
R6386 T7665 T7660 punct ),SDS
R6387 T7666 T7653 punct .,Tris
R6388 T7667 T7669 nsubjpass Chromatin,sonicated
R6389 T7668 T7669 auxpass was,sonicated
R6390 T7669 T7669 ROOT sonicated,sonicated
R6391 T7670 T7669 advcl using,sonicated
R6392 T7671 T7673 compound Bandelin,GM70
R6393 T7672 T7673 compound Sonoplus,GM70
R6394 T7673 T7670 dobj GM70,using
R6395 T7674 T7673 punct (,GM70
R6396 T7675 T7676 compound Bandelin,Electronic
R6397 T7676 T7673 appos Electronic,GM70
R6398 T7677 T7676 punct ",",Electronic
R6399 T7678 T7676 conj Berlin,Electronic
R6400 T7679 T7678 punct ",",Berlin
R6401 T7680 T7678 conj Germany,Berlin
R6402 T7681 T7673 punct ),GM70
R6403 T7682 T7673 punct ",",GM70
R6404 T7683 T7673 amod centrifuged,GM70
R6405 T7684 T7696 punct (,was
R6406 T7685 T7686 nummod 14,000
R6407 T7686 T7688 nummod 000,g
R6408 T7687 T7688 compound ×,g
R6409 T7688 T7696 acomp g,was
R6410 T7689 T7691 punct ",",min
R6411 T7690 T7691 nummod 15,min
R6412 T7691 T7688 appos min,g
R6413 T7692 T7688 punct ),g
R6414 T7693 T7688 punct ",",g
R6415 T7694 T7688 cc and,g
R6416 T7695 T7696 nsubj supernatant,was
R6417 T7696 T7696 ROOT was,was
R6418 T7697 T7698 advmod 10-fold,diluted
R6419 T7698 T7696 acomp diluted,was
R6420 T7699 T7698 prep in,diluted
R6421 T7700 T7701 compound dilution,buffer
R6422 T7701 T7699 pobj buffer,in
R6423 T7702 T7705 punct (,SDS
R6424 T7703 T7704 nummod 0.01,%
R6425 T7704 T7705 npadvmod %,SDS
R6426 T7705 T7696 parataxis SDS,was
R6427 T7706 T7705 punct ",",SDS
R6428 T7707 T7709 nummod 16.7,Tris
R6429 T7708 T7709 compound mM,Tris
R6430 T7709 T7705 conj Tris,SDS
R6431 T7710 T7711 compound HCl,pH
R6432 T7711 T7705 npadvmod pH,SDS
R6433 T7712 T7711 nummod 8.0,pH
R6434 T7713 T7711 punct ",",pH
R6435 T7714 T7715 nummod 1.1,%
R6436 T7715 T7717 compound %,X-100
R6437 T7716 T7717 compound Triton,X-100
R6438 T7717 T7711 conj X-100,pH
R6439 T7718 T7717 punct ",",X-100
R6440 T7719 T7721 nummod 167,NaCl
R6441 T7720 T7721 compound mM,NaCl
R6442 T7721 T7717 conj NaCl,X-100
R6443 T7722 T7721 punct ",",NaCl
R6444 T7723 T7725 nummod 1.2,EDTA
R6445 T7724 T7725 compound mM,EDTA
R6446 T7725 T7721 appos EDTA,NaCl
R6447 T7726 T7721 punct ),NaCl
R6448 T7727 T7705 punct .,SDS
R6449 T7728 T7730 nsubjpass Samples,pre-cleared
R6450 T7729 T7730 auxpass were,pre-cleared
R6451 T7730 T7730 ROOT pre-cleared,pre-cleared
R6452 T7731 T7730 agent by,pre-cleared
R6453 T7732 T7733 amod 3-h,incubation
R6454 T7733 T7731 pobj incubation,by
R6455 T7734 T7730 prep with,pre-cleared
R6456 T7735 T7736 nummod 20,µl
R6457 T7736 T7734 pobj µl,with
R6458 T7737 T7736 prep of,µl
R6459 T7738 T7741 nmod protein,beads
R6460 T7739 T7741 nmod G,beads
R6461 T7740 T7741 amod agarose,beads
R6462 T7741 T7737 pobj beads,of
R6463 T7742 T7741 acl followed,beads
R6464 T7743 T7742 agent by,followed
R6465 T7744 T7743 pobj incubation,by
R6466 T7745 T7742 prep with,followed
R6467 T7746 T7745 pobj antibodies,with
R6468 T7747 T7746 prep against,antibodies
R6469 T7748 T7750 det the,proteins
R6470 T7749 T7750 amod analysed,proteins
R6471 T7750 T7747 pobj proteins,against
R6472 T7751 T7730 punct .,pre-cleared
R6473 T7752 T7753 amod Primary,antibodies
R6474 T7753 T7754 nsubj antibodies,were
R6475 T7754 T7754 ROOT were,were
R6476 T7755 T7754 punct :,were
R6477 T7756 T7767 amod anti-p65,IgG
R6478 T7757 T7767 punct (,IgG
R6479 T7758 T7767 amod sc-372,IgG
R6480 T7759 T7758 punct ),sc-372
R6481 T7760 T7758 punct ",",sc-372
R6482 T7761 T7758 conj anti-IκBα,sc-372
R6483 T7762 T7763 punct (,sc-203
R6484 T7763 T7767 amod sc-203,IgG
R6485 T7764 T7763 punct ),sc-203
R6486 T7765 T7763 cc and,sc-203
R6487 T7766 T7763 conj rabbit,sc-203
R6488 T7767 T7754 attr IgG,were
R6489 T7768 T7769 punct (,sc-2027
R6490 T7769 T7767 appos sc-2027,IgG
R6491 T7770 T7769 punct ),sc-2027
R6492 T7771 T7769 prep from,sc-2027
R6493 T7772 T7773 compound Santa,Cruz
R6494 T7773 T7774 compound Cruz,Biotechnology
R6495 T7774 T7771 pobj Biotechnology,from
R6496 T7775 T7767 punct ;,IgG
R6497 T7776 T7777 compound anti-FLAG,M2
R6498 T7777 T7767 conj M2,IgG
R6499 T7778 T7767 prep from,IgG
R6500 T7779 T7778 pobj Sigma,from
R6501 T7780 T7767 conj Aldrich,IgG
R6502 T7781 T7767 punct .,IgG
R6503 T7782 T7784 nsubjpass Immunoprecipitations,carried
R6504 T7783 T7784 auxpass were,carried
R6505 T7784 T7784 ROOT carried,carried
R6506 T7785 T7784 prt out,carried
R6507 T7786 T7784 prep at,carried
R6508 T7787 T7788 nummod 4,°
R6509 T7788 T7790 nummod °,overnight
R6510 T7789 T7790 compound C,overnight
R6511 T7790 T7786 pobj overnight,at
R6512 T7791 T7790 cc and,overnight
R6513 T7792 T7790 conj immune,overnight
R6514 T7793 T7795 nsubjpass complexes,collected
R6515 T7794 T7795 auxpass were,collected
R6516 T7795 T7784 conj collected,carried
R6517 T7796 T7795 prep with,collected
R6518 T7797 T7800 nmod protein,beads
R6519 T7798 T7800 nmod G,beads
R6520 T7799 T7800 amod agarose,beads
R6521 T7800 T7796 pobj beads,with
R6522 T7801 T7802 punct ",",washed
R6523 T7802 T7784 conj washed,carried
R6524 T7803 T7804 nummod five,times
R6525 T7804 T7802 npadvmod times,washed
R6526 T7805 T7802 prep with,washed
R6527 T7806 T7808 amod low,buffer
R6528 T7807 T7808 compound salt,buffer
R6529 T7808 T7805 pobj buffer,with
R6530 T7809 T7808 punct (,buffer
R6531 T7810 T7812 nummod 20,Tris
R6532 T7811 T7812 compound mM,Tris
R6533 T7812 T7808 appos Tris,buffer
R6534 T7813 T7814 compound HCl,pH
R6535 T7814 T7808 appos pH,buffer
R6536 T7815 T7814 nummod 8.0,pH
R6537 T7816 T7814 punct ",",pH
R6538 T7817 T7818 nummod 0.1,%
R6539 T7818 T7819 npadvmod %,SDS
R6540 T7819 T7814 appos SDS,pH
R6541 T7820 T7819 punct ",",SDS
R6542 T7821 T7822 nummod 1,%
R6543 T7822 T7824 compound %,X-100
R6544 T7823 T7824 compound Triton,X-100
R6545 T7824 T7819 conj X-100,SDS
R6546 T7825 T7824 punct ",",X-100
R6547 T7826 T7828 nummod 2,EDTA
R6548 T7827 T7828 compound mM,EDTA
R6549 T7828 T7824 conj EDTA,X-100
R6550 T7829 T7828 punct ",",EDTA
R6551 T7830 T7832 nummod 150,NaCl
R6552 T7831 T7832 compound mM,NaCl
R6553 T7832 T7828 appos NaCl,EDTA
R6554 T7833 T7828 punct ),EDTA
R6555 T7834 T7819 punct ",",SDS
R6556 T7835 T7836 nummod four,times
R6557 T7836 T7819 npadvmod times,SDS
R6558 T7837 T7819 prep with,SDS
R6559 T7838 T7840 amod high,buffer
R6560 T7839 T7840 compound salt,buffer
R6561 T7840 T7837 pobj buffer,with
R6562 T7841 T7844 punct (,Tris
R6563 T7842 T7844 nummod 20,Tris
R6564 T7843 T7844 compound mM,Tris
R6565 T7844 T7840 appos Tris,buffer
R6566 T7845 T7846 compound HCl,pH
R6567 T7846 T7885 nsubj pH,extracted
R6568 T7847 T7846 nummod 8.0,pH
R6569 T7848 T7846 punct ",",pH
R6570 T7849 T7850 nummod 0.1,%
R6571 T7850 T7851 npadvmod %,SDS
R6572 T7851 T7846 npadvmod SDS,pH
R6573 T7852 T7851 punct ",",SDS
R6574 T7853 T7854 nummod 1,%
R6575 T7854 T7856 compound %,X-100
R6576 T7855 T7856 compound Triton,X-100
R6577 T7856 T7851 appos X-100,SDS
R6578 T7857 T7856 punct ",",X-100
R6579 T7858 T7860 nummod 2,EDTA
R6580 T7859 T7860 compound mM,EDTA
R6581 T7860 T7856 conj EDTA,X-100
R6582 T7861 T7860 punct ",",EDTA
R6583 T7862 T7864 nummod 500,NaCl
R6584 T7863 T7864 compound mM,NaCl
R6585 T7864 T7860 appos NaCl,EDTA
R6586 T7865 T7860 punct ),EDTA
R6587 T7866 T7851 punct ",",SDS
R6588 T7867 T7868 advmod once,with
R6589 T7868 T7851 prep with,SDS
R6590 T7869 T7870 compound TE,buffer
R6591 T7870 T7868 pobj buffer,with
R6592 T7871 T7851 punct (,SDS
R6593 T7872 T7874 nummod 10,Tris
R6594 T7873 T7874 compound mM,Tris
R6595 T7874 T7851 appos Tris,SDS
R6596 T7875 T7876 compound HCl,pH
R6597 T7876 T7851 appos pH,SDS
R6598 T7877 T7876 nummod 8.0,pH
R6599 T7878 T7876 punct ",",pH
R6600 T7879 T7881 nummod 1,EDTA
R6601 T7880 T7881 compound mM,EDTA
R6602 T7881 T7876 appos EDTA,pH
R6603 T7882 T7876 punct ),pH
R6604 T7883 T7851 punct ",",SDS
R6605 T7884 T7846 cc and,pH
R6606 T7885 T7885 ROOT extracted,extracted
R6607 T7886 T7885 prep in,extracted
R6608 T7887 T7888 compound TE,buffer
R6609 T7888 T7886 pobj buffer,in
R6610 T7889 T7888 acl containing,buffer
R6611 T7890 T7891 nummod 2,%
R6612 T7891 T7889 dobj %,containing
R6613 T7892 T7889 npadvmod SDS,containing
R6614 T7893 T7885 punct .,extracted
R6615 T7894 T7894 ROOT Protein,Protein
R6616 T7895 T7896 compound DNA,cross-links
R6617 T7896 T7898 nsubjpass cross-links,reverted
R6618 T7897 T7898 auxpass were,reverted
R6619 T7898 T7898 ROOT reverted,reverted
R6620 T7899 T7898 agent by,reverted
R6621 T7900 T7899 pobj heating,by
R6622 T7901 T7898 prep at,reverted
R6623 T7902 T7904 nummod 65,C
R6624 T7903 T7904 nummod °,C
R6625 T7904 T7905 compound C,overnight
R6626 T7905 T7901 pobj overnight,at
R6627 T7906 T7898 punct .,reverted
R6628 T7907 T7910 nsubjpass DNA,purified
R6629 T7908 T7910 auxpass was,purified
R6630 T7909 T7910 advmod further,purified
R6631 T7910 T7910 ROOT purified,purified
R6650 T7929 T7935 nsubjpass enrichment,measured
R6651 T7930 T7929 prep in,enrichment
R6652 T7931 T7933 amod NF-κB,sequences
R6653 T7932 T7933 compound enhancer,sequences
R6654 T7933 T7930 pobj sequences,in
R6655 T7934 T7935 auxpass was,measured
R6656 T7935 T7935 ROOT measured,measured
R6657 T7936 T7935 agent by,measured
R6658 T7937 T7938 amod real-time,PCR
R6659 T7938 T7936 pobj PCR,by
R6660 T7939 T7938 prep of,PCR
R6661 T7940 T7941 compound chromatin,immunoprecipitation
R6662 T7941 T7939 pobj immunoprecipitation,of
R6663 T7942 T7943 punct (,ChIP
R6664 T7943 T7941 appos ChIP,immunoprecipitation
R6665 T7944 T7941 punct ),immunoprecipitation
R6666 T7945 T7935 oprd eluates,measured
R6667 T7946 T7945 advcl using,eluates
R6668 T7947 T7950 compound SYBR,Mix
R6669 T7948 T7950 compound GreenER,Mix
R6670 T7949 T7950 compound Master,Mix
R6671 T7950 T7946 dobj Mix,using
R6672 T7951 T7950 punct (,Mix
R6673 T7952 T7950 appos Invitrogen,Mix
R6674 T7953 T7950 punct ),Mix
R6675 T7954 T7935 punct .,measured
R6676 T7955 T7957 nsubjpass Reactions,carried
R6677 T7956 T7957 auxpass were,carried
R6678 T7957 T7957 ROOT carried,carried
R6679 T7958 T7957 prt out,carried
R6680 T7959 T7957 prep with,carried
R6681 T7960 T7965 det the,system
R6682 T7961 T7963 compound iCycler,Real-Time
R6683 T7962 T7963 compound iQ,Real-Time
R6684 T7963 T7965 compound Real-Time,system
R6685 T7964 T7965 compound detection,system
R6686 T7965 T7959 pobj system,with
R6687 T7966 T7965 punct (,system
R6688 T7967 T7968 compound Bio-Rad,Laboratories
R6689 T7968 T7965 appos Laboratories,system
R6690 T7969 T7965 punct ),system
R6691 T7970 T7957 advcl using,carried
R6692 T7971 T7973 det the,conditions
R6693 T7972 T7973 amod following,conditions
R6694 T7973 T7970 dobj conditions,using
R6695 T7974 T7973 punct :,conditions
R6696 T7975 T7976 nummod 95,°
R6697 T7976 T7977 compound °,C
R6698 T7977 T7973 appos C,conditions
R6699 T7978 T7977 punct ",",C
R6700 T7979 T7980 nummod 1,min
R6701 T7980 T7977 appos min,C
R6702 T7981 T7977 punct ;,C
R6703 T7982 T7985 punct (,C
R6704 T7983 T7984 nummod 94,°
R6705 T7984 T7985 compound °,C
R6706 T7985 T7977 appos C,C
R6707 T7986 T7985 punct ",",C
R6708 T7987 T7988 nsubj 10,s
R6709 T7988 T7977 appos s,C
R6710 T7989 T7977 punct ;,C
R6711 T7990 T7991 nummod 60,°
R6712 T7991 T7992 compound °,C
R6713 T7992 T7977 conj C,C
R6714 T7993 T7992 punct ",",C
R6715 T7994 T7995 nummod 30,s
R6716 T7995 T7992 appos s,C
R6717 T7996 T7992 punct ),C
R6718 T7997 T7998 advmod ×,40
R6719 T7998 T7977 appos 40,C
R6720 T7999 T7957 punct .,carried
R6721 T8000 T8009 nsubjpass Primers,listed
R6722 T8001 T8000 acl used,Primers
R6723 T8002 T8001 prep for,used
R6724 T8003 T8002 pobj MIP-1α,for
R6725 T8004 T8003 punct ",",MIP-1α
R6726 T8005 T8003 conj GAPDH,MIP-1α
R6727 T8006 T8005 cc and,GAPDH
R6728 T8007 T8005 conj ACTB,GAPDH
R6729 T8008 T8009 auxpass are,listed
R6730 T8009 T8009 ROOT listed,listed
R6731 T8010 T8009 prep in,listed
R6732 T8011 T8012 compound Supplementary,Data
R6733 T8012 T8010 pobj Data,in
R6734 T8013 T8009 punct .,listed
R6735 T8014 T8015 amod Real-time,PCR
R6736 T8015 T8025 nsubjpass PCR,performed
R6737 T8016 T8015 prep of,PCR
R6738 T8017 T8016 pobj CSF3,of
R6739 T8018 T8017 punct ",",CSF3
R6740 T8019 T8017 conj LTA,CSF3
R6741 T8020 T8019 punct ",",LTA
R6742 T8021 T8019 conj NFKBIA,LTA
R6743 T8022 T8021 cc and,NFKBIA
R6744 T8023 T8021 conj TLR2,NFKBIA
R6745 T8024 T8025 auxpass were,performed
R6746 T8025 T8025 ROOT performed,performed
R6747 T8026 T8025 advcl using,performed
R6748 T8027 T8030 det the,array
R6749 T8028 T8030 compound Custom,array
R6750 T8029 T8030 compound ChIP,array
R6751 T8030 T8026 dobj array,using
R6752 T8031 T8030 punct (,array
R6753 T8032 T8030 appos QIAGEN,array
R6754 T8033 T8030 punct ),array
R6755 T8034 T8025 punct .,performed
R6756 T8035 T8040 prep For,were
R6757 T8036 T8037 det each,sample
R6758 T8037 T8035 pobj sample,For
R6759 T8038 T8040 punct ",",were
R6760 T8039 T8040 nsubj values,were
R6761 T8040 T8040 ROOT were,were
R6762 T8041 T8040 acomp normalized,were
R6763 T8042 T8041 prep to,normalized
R6764 T8043 T8046 dep input,reported
R6765 T8044 T8043 dobj DNA,input
R6766 T8045 T8043 cc and,input
R6767 T8046 T8040 conj reported,were
R6768 T8047 T8048 mark as,%
R6769 T8048 T8046 advcl %,reported
R6770 T8049 T8048 prep of,%
R6771 T8050 T8049 pobj input,of
R6772 T8051 T8048 prep over,%
R6773 T8052 T8053 det the,rabbit
R6774 T8053 T8051 pobj rabbit,over
R6775 T8054 T8055 compound IgG,control
R6776 T8055 T8048 conj control,%
R6777 T8056 T8046 punct .,reported
R6815 T8195 T8196 compound Statistical,analysis
R6816 T8196 T8198 compound analysis,analysis
R6817 T8197 T8198 compound Statistical,analysis
R6818 T8198 T8200 nsubjpass analysis,performed
R6819 T8199 T8200 auxpass was,performed
R6820 T8200 T8200 ROOT performed,performed
R6821 T8201 T8200 agent by,performed
R6822 T8202 T8204 compound two-tail,Student
R6823 T8203 T8204 compound unpaired,Student
R6824 T8204 T8201 pobj Student,by
R6825 T8205 T8204 case 's,Student
R6826 T8206 T8204 amod t-test,Student
R6827 T8207 T8200 punct .,performed
R6828 T8208 T8210 nsubjpass Data,reported
R6829 T8209 T8210 auxpass were,reported
R6830 T8210 T8210 ROOT reported,reported
R6831 T8211 T8210 prep as,reported
R6832 T8212 T8211 pobj means,as
R6833 T8213 T8214 compound ±,SE
R6834 T8214 T8212 dobj SE,means
R6835 T8215 T8210 punct .,reported
R6836 T8216 T8221 nsubjpass Differences,considered
R6837 T8217 T8216 prep between,Differences
R6838 T8218 T8219 det the,means
R6839 T8219 T8217 pobj means,between
R6840 T8220 T8221 auxpass were,considered
R6841 T8221 T8221 ROOT considered,considered
R6842 T8222 T8221 prep as,considered
R6843 T8223 T8224 advmod statistically,significant
R6844 T8224 T8222 amod significant,as
R6845 T8225 T8224 prep at,significant
R6846 T8226 T8229 det the,level
R6847 T8227 T8228 nummod 95,%
R6848 T8228 T8229 compound %,level
R6849 T8229 T8225 pobj level,at
R6850 T8230 T8229 punct (,level
R6851 T8231 T8234 nmod P,)
R6852 T8232 T8233 compound <,0.05
R6853 T8233 T8231 nummod 0.05,P
R6854 T8234 T8229 punct ),level
R6855 T8235 T8221 punct .,considered
R7872 T9532 T9533 nsubj Tat,enhances
R7873 T9533 T9533 ROOT enhances,enhances
R7874 T9534 T9536 det the,activity
R7875 T9535 T9536 amod NF-κB,activity
R7876 T9536 T9533 dobj activity,enhances
R7877 T9537 T9536 prep by,activity
R7878 T9538 T9537 pcomp hijacking,by
R7879 T9539 T9538 dobj IκB-α,hijacking
R7880 T9540 T9538 cc and,hijacking
R7881 T9541 T9538 conj inhibiting,hijacking
R7882 T9542 T9544 det the,turn
R7883 T9543 T9544 nsubj post-activation,turn
R7884 T9544 T9541 dobj turn,inhibiting
R7885 T9545 T9544 prt off,turn
R7886 T9546 T9545 prep of,off
R7887 T9547 T9546 pobj NF-κB,of
R7888 T9548 T9549 nsubj We,analysed
R7889 T9549 T9536 relcl analysed,activity
R7890 T9550 T9551 det the,kinetic
R7891 T9551 T9549 dobj kinetic,analysed
R7892 T9552 T9551 prep of,kinetic
R7893 T9553 T9554 amod NF-κB,activation
R7894 T9554 T9552 pobj activation,of
R7895 T9555 T9554 prep in,activation
R7896 T9556 T9559 amod single,infection
R7897 T9557 T9559 compound round,infection
R7898 T9558 T9559 compound HIV-1,infection
R7899 T9559 T9555 pobj infection,in
R7900 T9560 T9549 prep by,analysed
R7901 T9561 T9560 pcomp modulating,by
R7902 T9562 T9563 det the,expression
R7903 T9563 T9561 dobj expression,modulating
R7904 T9564 T9563 prep of,expression
R7905 T9565 T9564 pobj Tat,of
R7906 T9566 T9561 prep with,modulating
R7907 T9567 T9568 compound RNA,interference
R7908 T9568 T9566 pobj interference,with
R7909 T9569 T9533 punct .,enhances
R7910 T9570 T9571 compound Jurkat,cells
R7911 T9571 T9573 nsubjpass cells,transfected
R7912 T9572 T9573 auxpass were,transfected
R7913 T9573 T9573 ROOT transfected,transfected
R7914 T9574 T9573 prep with,transfected
R7915 T9575 T9576 compound siRNA,Tat
R7916 T9576 T9574 pobj Tat,with
R7917 T9577 T9573 punct ",",transfected
R7918 T9578 T9579 compound siRNA,control
R7919 T9579 T9573 conj control,transfected
R7920 T9580 T9579 punct ",",control
R7921 T9581 T9579 cc or,control
R7922 T9582 T9573 conj left,transfected
R7923 T9583 T9582 oprd untransfected,left
R7924 T9584 T9582 punct ",",left
R7925 T9585 T9582 cc and,left
R7926 T9586 T9589 nummod 24,cells
R7927 T9587 T9589 nmod h,cells
R7928 T9588 T9589 amod later,cells
R7929 T9589 T9591 nsubjpass cells,infected
R7930 T9590 T9591 auxpass were,infected
R7931 T9591 T9582 conj infected,left
R7932 T9592 T9591 prep with,infected
R7933 T9593 T9595 nummod HXB2,NL4-3
R7934 T9594 T9595 amod Env-pseudotyped,NL4-3
R7935 T9595 T9592 pobj NL4-3,with
R7936 T9596 T9591 punct .,infected
R7937 T9597 T9601 compound Luc.R,virions
R7938 T9598 T9601 compound −,virions
R7939 T9599 T9600 compound E,−
R7940 T9600 T9601 compound −,virions
R7941 T9601 T9601 ROOT virions,virions
R7942 T9602 T9601 punct .,virions
R7943 T9603 T9612 prep By,was
R7944 T9604 T9605 amod cytofluorimetric,analysis
R7945 T9605 T9603 pobj analysis,By
R7946 T9606 T9612 punct ",",was
R7947 T9607 T9612 advmod ∼,was
R7948 T9608 T9609 nummod 40,%
R7949 T9609 T9612 nsubj %,was
R7950 T9610 T9609 prep of,%
R7951 T9611 T9610 pobj cells,of
R7952 T9612 T9612 ROOT was,was
R7953 T9613 T9612 acomp siRNA-transfected,was
R7954 T9614 T9613 cc and,siRNA-transfected
R7955 T9615 T9613 conj HIV-1-infected,siRNA-transfected
R7956 T9616 T9612 prep at,was
R7957 T9617 T9618 amod 12-h,post-infection
R7958 T9618 T9616 pobj post-infection,at
R7959 T9619 T9622 punct (,S1
R7960 T9620 T9622 compound Supplementary,S1
R7961 T9621 T9622 compound Figure,S1
R7962 T9622 T9618 appos S1,post-infection
R7963 T9623 T9622 punct ),S1
R7964 T9624 T9612 punct .,was
R7965 T9625 T9626 det The,expression
R7966 T9626 T9630 nsubjpass expression,detected
R7967 T9627 T9626 prep of,expression
R7968 T9628 T9627 pobj Tat,of
R7969 T9629 T9630 auxpass was,detected
R7970 T9630 T9630 ROOT detected,detected
R7971 T9631 T9630 prep at,detected
R7972 T9632 T9633 compound 1-h,post-infection
R7973 T9633 T9631 pobj post-infection,at
R7974 T9634 T9630 cc and,detected
R7975 T9635 T9636 advmod progressively,increased
R7976 T9636 T9630 conj increased,detected
R7977 T9637 T9636 prt up,increased
R7978 T9638 T9636 prep to,increased
R7979 T9639 T9640 nummod 12,h
R7980 T9640 T9638 pobj h,to
R7981 T9641 T9640 prep in,h
R7982 T9642 T9646 amod untransfected,cells
R7983 T9643 T9642 cc and,untransfected
R7984 T9644 T9642 conj siRNA,untransfected
R7985 T9645 T9646 amod control-transfected,cells
R7986 T9646 T9641 pobj cells,in
R7987 T9647 T9636 punct ",",increased
R7988 T9648 T9652 mark while,detected
R7989 T9649 T9652 nsubjpass it,detected
R7990 T9650 T9652 auxpass was,detected
R7991 T9651 T9652 advmod barely,detected
R7992 T9652 T9636 advcl detected,increased
R7993 T9653 T9652 prep in,detected
R7994 T9654 T9653 pobj siRNA,in
R7995 T9655 T9656 amod Tat-transfected,cells
R7996 T9656 T9652 dobj cells,detected
R7997 T9657 T9658 punct (,Figure
R7998 T9658 T9656 parataxis Figure,cells
R7999 T9659 T9658 nummod 1A,Figure
R8000 T9660 T9658 punct ),Figure
R8001 T9661 T9630 punct .,detected
R8002 T9662 T9665 det The,expression
R8003 T9663 T9665 amod LTR-dependent,expression
R8004 T9664 T9665 compound luciferase,expression
R8005 T9665 T9669 nsubjpass expression,induced
R8006 T9666 T9669 auxpass was,induced
R8007 T9667 T9666 advmod also,was
R8008 T9668 T9669 advmod progressively,induced
R8009 T9669 T9669 ROOT induced,induced
R8010 T9670 T9669 prep at,induced
R8011 T9671 T9670 pobj 1,at
R8012 T9672 T9669 punct -,induced
R8013 T9673 T9669 prep to,induced
R8014 T9674 T9675 amod 12-h,post-infection
R8015 T9675 T9673 pobj post-infection,to
R8016 T9676 T9675 prep in,post-infection
R8017 T9677 T9681 amod untransfected,cells
R8018 T9678 T9677 cc and,untransfected
R8019 T9679 T9677 conj siRNA,untransfected
R8020 T9680 T9681 amod control-transfected,cells
R8021 T9681 T9676 pobj cells,in
R8022 T9682 T9669 punct ",",induced
R8023 T9683 T9687 mark while,observed
R8024 T9684 T9687 nsubjpass it,observed
R8025 T9685 T9687 auxpass was,observed
R8026 T9686 T9687 advmod barely,observed
R8027 T9687 T9669 advcl observed,induced
R8028 T9688 T9687 prep in,observed
R8029 T9689 T9688 pobj siRNA,in
R8030 T9690 T9691 amod Tat-transfected,cells
R8031 T9691 T9687 dobj cells,observed
R8032 T9692 T9687 punct ",",observed
R8033 T9693 T9694 mark as,expected
R8034 T9694 T9687 advcl expected,observed
R8035 T9695 T9694 prep for,expected
R8036 T9696 T9698 det the,transactivation
R8037 T9697 T9698 amod Tat-dependent,transactivation
R8038 T9698 T9695 pobj transactivation,for
R8039 T9699 T9698 prep of,transactivation
R8040 T9700 T9702 det the,LTR
R8041 T9701 T9702 compound HIV-1,LTR
R8042 T9702 T9699 pobj LTR,of
R8043 T9703 T9705 punct (,1A
R8044 T9704 T9705 compound Figure,1A
R8045 T9705 T9702 appos 1A,LTR
R8046 T9706 T9702 punct ),LTR
R8047 T9707 T9669 punct .,induced
R8048 T9708 T9710 det The,increase
R8049 T9709 T9710 amod progressive,increase
R8050 T9710 T9741 nsubjpass increase,observed
R8051 T9711 T9710 prep in,increase
R8052 T9712 T9713 amod NF-κB,activity
R8053 T9713 T9711 pobj activity,in
R8054 T9714 T9710 punct ",",increase
R8055 T9715 T9716 mark as,measured
R8056 T9716 T9710 advcl measured,increase
R8057 T9717 T9716 agent by,measured
R8058 T9718 T9717 pobj p65,by
R8059 T9719 T9718 amod p50,p65
R8060 T9720 T9718 amod binding,p65
R8061 T9721 T9720 prep to,binding
R8062 T9722 T9724 det an,consensus
R8063 T9723 T9724 amod NF-κB,consensus
R8064 T9724 T9721 pobj consensus,to
R8065 T9725 T9724 appos oligonucleotide,consensus
R8066 T9726 T9727 punct (,Figure
R8067 T9727 T9728 nmod Figure,1B
R8068 T9728 T9725 appos 1B,oligonucleotide
R8069 T9729 T9728 punct ),1B
R8070 T9730 T9728 cc and,1B
R8071 T9731 T9732 amod nuclear,p65
R8072 T9732 T9728 conj p65,1B
R8073 T9733 T9734 punct (,Figure
R8074 T9734 T9724 appos Figure,consensus
R8075 T9735 T9734 nummod 1C,Figure
R8076 T9736 T9734 punct ",",Figure
R8077 T9737 T9734 appos nucleus,Figure
R8078 T9738 T9734 punct ),Figure
R8079 T9739 T9710 punct ",",increase
R8080 T9740 T9741 auxpass was,observed
R8081 T9741 T9775 ccomp observed,binding
R8082 T9742 T9741 prep at,observed
R8083 T9743 T9745 meta 1,to
R8084 T9744 T9745 punct -,to
R8085 T9745 T9741 prep to,observed
R8086 T9746 T9747 amod 3-h,post-infection
R8087 T9747 T9745 pobj post-infection,to
R8088 T9748 T9747 prep in,post-infection
R8089 T9749 T9750 det both,Tat-positive
R8090 T9750 T9748 pobj Tat-positive,in
R8091 T9751 T9750 punct (,Tat-positive
R8092 T9752 T9753 det no,siRNA
R8093 T9753 T9750 appos siRNA,Tat-positive
R8094 T9754 T9753 cc or,siRNA
R8095 T9755 T9756 compound siRNA,control
R8096 T9756 T9753 conj control,siRNA
R8097 T9757 T9753 punct ),siRNA
R8098 T9758 T9750 cc and,Tat-positive
R8099 T9759 T9750 conj Tat-negative,Tat-positive
R8100 T9760 T9762 punct (,Tat
R8101 T9761 T9762 compound siRNA,Tat
R8102 T9762 T9750 appos Tat,Tat-positive
R8103 T9763 T9762 punct ),Tat
R8104 T9764 T9748 pobj cells,in
R8105 T9765 T9775 punct ;,binding
R8106 T9766 T9775 advmod however,binding
R8107 T9767 T9775 punct ",",binding
R8108 T9768 T9775 prep at,binding
R8109 T9769 T9770 amod 12-h,post-infection
R8110 T9770 T9768 pobj post-infection,at
R8111 T9771 T9775 punct ",",binding
R8112 T9772 T9774 det the,DNA
R8113 T9773 T9774 nummod p65,DNA
R8114 T9774 T9775 nsubj DNA,binding
R8115 T9775 T9778 amod binding,p65
R8116 T9776 T9775 cc and,binding
R8117 T9777 T9775 conj nuclear,binding
R8118 T9778 T9779 nsubj p65,persisted
R8119 T9779 T9779 ROOT persisted,persisted
R8120 T9780 T9779 conj elevated,persisted
R8121 T9781 T9780 prep in,elevated
R8122 T9782 T9781 pobj presence,in
R8123 T9783 T9782 prep of,presence
R8124 T9784 T9783 pobj Tat,of
R8125 T9785 T9782 punct (,presence
R8126 T9786 T9787 det no,siRNA
R8127 T9787 T9782 appos siRNA,presence
R8128 T9788 T9787 cc and,siRNA
R8129 T9789 T9790 compound siRNA,control
R8130 T9790 T9787 conj control,siRNA
R8131 T9791 T9787 punct ),siRNA
R8132 T9792 T9780 punct ",",elevated
R8133 T9793 T9795 mark while,dropped
R8134 T9794 T9795 nsubj they,dropped
R8135 T9795 T9780 advcl dropped,elevated
R8136 T9796 T9795 prep in,dropped
R8137 T9797 T9796 pobj absence,in
R8138 T9798 T9797 prep of,absence
R8139 T9799 T9798 pobj Tat,of
R8140 T9800 T9799 punct (,Tat
R8141 T9801 T9802 compound siRNA,Tat
R8142 T9802 T9799 appos Tat,Tat
R8143 T9803 T9799 punct ),Tat
R8144 T9804 T9805 punct (,Figure
R8145 T9805 T9795 parataxis Figure,dropped
R8146 T9806 T9805 nummod 1B,Figure
R8147 T9807 T9805 cc and,Figure
R8148 T9808 T9805 conj C,Figure
R8149 T9809 T9805 punct ),Figure
R8150 T9810 T9779 punct .,persisted
R8151 T9811 T9813 nsubjpass IκB-α,degraded
R8152 T9812 T9813 auxpass was,degraded
R8153 T9813 T9813 ROOT degraded,degraded
R8154 T9814 T9813 prep in,degraded
R8155 T9815 T9816 det the,cytosol
R8156 T9816 T9814 pobj cytosol,in
R8157 T9817 T9816 prep within,cytosol
R8158 T9818 T9819 compound 3-h,post-infection
R8159 T9819 T9817 pobj post-infection,within
R8160 T9820 T9814 cc and,in
R8161 T9821 T9823 mark de,synthesized
R8162 T9822 T9823 nsubj novo,synthesized
R8163 T9823 T9813 advcl synthesized,degraded
R8164 T9824 T9823 prep at,synthesized
R8165 T9825 T9826 nummod 6,h
R8166 T9826 T9824 pobj h,at
R8167 T9827 T9823 prep with,synthesized
R8168 T9828 T9829 amod full,replenishment
R8169 T9829 T9827 pobj replenishment,with
R8170 T9830 T9829 prep at,replenishment
R8171 T9831 T9832 amod 12-h,post-infection
R8172 T9832 T9830 pobj post-infection,at
R8173 T9833 T9823 prep in,synthesized
R8174 T9834 T9835 preconj both,Tat-positive
R8175 T9835 T9838 amod Tat-positive,cells
R8176 T9836 T9835 cc and,Tat-positive
R8177 T9837 T9835 conj Tat-negative,Tat-positive
R8178 T9838 T9833 pobj cells,in
R8179 T9839 T9840 punct (,Figure
R8180 T9840 T9840 ROOT Figure,Figure
R8181 T9841 T9840 nummod 1C,Figure
R8182 T9842 T9840 punct ",",Figure
R8183 T9843 T9840 dep cytosol,Figure
R8184 T9844 T9840 punct ),Figure
R8185 T9845 T9813 punct .,degraded
R8186 T9846 T9852 advmod Consistently,induced
R8187 T9847 T9852 punct ",",induced
R8188 T9848 T9850 det the,activity
R8189 T9849 T9850 compound IKK,activity
R8190 T9850 T9852 nsubjpass activity,induced
R8191 T9851 T9852 auxpass was,induced
R8192 T9852 T9852 ROOT induced,induced
R8193 T9853 T9852 prep at,induced
R8194 T9854 T9855 amod 1-h,post-infection
R8195 T9855 T9853 pobj post-infection,at
R8196 T9856 T9852 punct ",",induced
R8197 T9857 T9852 cc and,induced
R8198 T9858 T9852 conj decreased,induced
R8199 T9859 T9858 prep at,decreased
R8200 T9860 T9861 compound 3-h,post-infection
R8201 T9861 T9859 pobj post-infection,at
R8202 T9862 T9858 advmod independently,decreased
R8203 T9863 T9858 prep of,decreased
R8204 T9864 T9865 det the,presence
R8205 T9865 T9863 pobj presence,of
R8206 T9866 T9865 prep of,presence
R8207 T9867 T9866 pobj Tat,of
R8208 T9868 T9870 punct (,1D
R8209 T9869 T9870 compound Figure,1D
R8210 T9870 T9867 appos 1D,Tat
R8211 T9871 T9870 punct ),1D
R8212 T9872 T9852 punct .,induced
R8213 T9873 T9874 amod Similar,kinetics
R8214 T9874 T9885 nsubjpass kinetics,observed
R8215 T9875 T9874 prep of,kinetics
R8216 T9876 T9877 amod NF-κB,activity
R8217 T9877 T9875 pobj activity,of
R8218 T9878 T9874 punct ",",kinetics
R8219 T9879 T9880 compound IKK,activation
R8220 T9880 T9874 conj activation,kinetics
R8221 T9881 T9880 cc and,activation
R8222 T9882 T9883 amod IκB-α,degradation/re-synthesis
R8223 T9883 T9880 conj degradation/re-synthesis,activation
R8224 T9884 T9885 auxpass were,observed
R8225 T9885 T9885 ROOT observed,observed
R8226 T9886 T9885 prep in,observed
R8227 T9887 T9889 amod single-round,infection
R8228 T9888 T9889 amod HIV-1,infection
R8229 T9889 T9886 pobj infection,in
R8230 T9890 T9889 prep of,infection
R8251 T9911 T9912 compound Figure,S2
R8252 T9912 T9908 appos S2,inhibitors
R8253 T9913 T9908 punct ),inhibitors
R8254 T9914 T9885 punct .,observed
R8255 T9915 T9916 det These,results
R8256 T9916 T9917 nsubj results,indicated
R8257 T9917 T9917 ROOT indicated,indicated
R8258 T9918 T9927 mark that,correlated
R8259 T9919 T9927 prep in,correlated
R8260 T9920 T9922 amod single-round,infection
R8261 T9921 T9922 compound HIV-1,infection
R8262 T9922 T9919 pobj infection,in
R8263 T9923 T9925 det the,activation
R8264 T9924 T9925 compound NF-κB,activation
R8265 T9925 T9927 nsubj activation,correlated
R8266 T9926 T9927 advmod initially,correlated
R8267 T9927 T9917 ccomp correlated,indicated
R8268 T9928 T9927 prep with,correlated
R8269 T9929 T9931 det the,activation
R8270 T9930 T9931 compound IKK,activation
R8271 T9931 T9928 pobj activation,with
R8272 T9932 T9931 cc and,activation
R8273 T9933 T9934 amod IκB-α,degradation
R8274 T9934 T9931 conj degradation,activation
R8275 T9935 T9934 advmod independently,degradation
R8276 T9936 T9931 prep of,activation
R8277 T9937 T9938 det the,presence
R8278 T9938 T9936 pobj presence,of
R8279 T9939 T9938 prep of,presence
R8280 T9940 T9939 pobj Tat,of
R8281 T9941 T9927 punct ",",correlated
R8282 T9942 T9927 cc and,correlated
R8283 T9943 T9945 nsubjpass it,kept
R8284 T9944 T9945 auxpass was,kept
R8285 T9945 T9927 conj kept,correlated
R8286 T9946 T9945 xcomp elevated,kept
R8287 T9947 T9946 prep in,elevated
R8288 T9948 T9947 pobj presence,in
R8289 T9949 T9948 prep of,presence
R8290 T9950 T9949 pobj Tat,of
R8291 T9951 T9948 prep following,presence
R8292 T9952 T9953 det the,decay
R8293 T9953 T9951 pobj decay,following
R8294 T9954 T9953 prep of,decay
R8295 T9955 T9957 det the,activity
R8296 T9956 T9957 compound IKK,activity
R8297 T9957 T9954 pobj activity,of
R8298 T9958 T9957 cc and,activity
R8299 T9959 T9960 amod new,synthesis
R8300 T9960 T9957 conj synthesis,activity
R8301 T9961 T9960 prep of,synthesis
R8302 T9962 T9961 pobj IκB-α,of
R8303 T9963 T9917 punct .,indicated
R8304 T9964 T9967 advmod Next,tested
R8305 T9965 T9967 punct ",",tested
R8306 T9966 T9967 nsubj we,tested
R8307 T9967 T9967 ROOT tested,tested
R8308 T9968 T9970 det the,action
R8309 T9969 T9970 amod single,action
R8310 T9970 T9967 dobj action,tested
R8311 T9971 T9970 prep of,action
R8312 T9972 T9971 pobj Tat,of
R8313 T9973 T9970 prep on,action
R8314 T9974 T9975 det the,kinetic
R8315 T9975 T9973 pobj kinetic,on
R8316 T9976 T9975 prep of,kinetic
R8317 T9977 T9978 amod NF-κB,activity
R8318 T9978 T9976 pobj activity,of
R8319 T9979 T9978 acl induced,activity
R8320 T9980 T9979 agent by,induced
R8321 T9981 T9980 pobj PMA,by
R8322 T9982 T9967 punct .,tested
R8323 T9983 T9990 prep To,transfected
R8324 T9984 T9985 det this,end
R8325 T9985 T9983 pobj end,To
R8326 T9986 T9990 punct ",",transfected
R8327 T9987 T9988 compound HeLa,cells
R8328 T9988 T9990 nsubjpass cells,transfected
R8329 T9989 T9990 auxpass were,transfected
R8330 T9990 T9990 ROOT transfected,transfected
R8331 T9991 T9990 prep with,transfected
R8332 T9992 T9991 pobj p3x-FLAG-Tat,with
R8333 T9993 T9992 punct ",",p3x-FLAG-Tat
R8334 T9994 T9992 cc or,p3x-FLAG-Tat
R8335 T9995 T9996 amod empty,vector
R8336 T9996 T9992 conj vector,p3x-FLAG-Tat
R8337 T9997 T9990 punct ",",transfected
R8338 T9998 T9990 dep stimulated,transfected
R8339 T9999 T9998 prep with,stimulated
R8340 T10000 T9999 pobj PMA,with
R8341 T10001 T9998 prep for,stimulated
R8342 T10002 T10003 nummod 5,min
R8343 T10003 T10001 pobj min,for
R8344 T10004 T9998 punct ",",stimulated
R8345 T10005 T9990 cc and,transfected
R8346 T10006 T10007 advmod extensively,washed
R8347 T10007 T9990 conj washed,transfected
R8348 T10008 T10009 aux to,avoid
R8349 T10009 T10007 xcomp avoid,washed
R8350 T10010 T10012 det the,kinetic
R8351 T10011 T10012 amod oscillatory,kinetic
R8352 T10012 T10009 dobj kinetic,avoid
R8353 T10013 T10012 prep of,kinetic
R8354 T10014 T10015 amod NF-κB,activation
R8355 T10015 T10013 pobj activation,of
R8356 T10016 T10015 punct (,activation
R8357 T10017 T10015 appos "17,18",activation
R8358 T10018 T10015 punct ),activation
R8359 T10019 T9990 punct .,transfected
R8360 T10020 T10043 prep In,enhanced
R8361 T10021 T10022 amod un-stimulated,cells
R8362 T10022 T10020 pobj cells,In
R8363 T10023 T10043 punct ",",enhanced
R8364 T10024 T10026 det the,DNA
R8365 T10025 T10026 nummod p65,DNA
R8366 T10026 T10043 nsubjpass DNA,enhanced
R8367 T10027 T10043 amod binding,enhanced
R8368 T10028 T10030 punct (,2A
R8369 T10029 T10030 nmod Figure,2A
R8370 T10030 T10027 appos 2A,binding
R8371 T10031 T10030 punct ),2A
R8372 T10032 T10030 cc and,2A
R8373 T10033 T10034 amod nuclear,p65
R8374 T10034 T10030 conj p65,2A
R8375 T10035 T10037 punct (,2B
R8376 T10036 T10037 compound Figure,2B
R8377 T10037 T10043 nsubjpass 2B,enhanced
R8378 T10038 T10037 punct ",",2B
R8379 T10039 T10037 appos nucleus,2B
R8380 T10040 T10037 punct ),2B
R8381 T10041 T10043 auxpass were,enhanced
R8382 T10042 T10043 advmod slightly,enhanced
R8383 T10043 T10043 ROOT enhanced,enhanced
R8384 T10044 T10043 agent by,enhanced
R8385 T10045 T10044 pobj Tat,by
R8386 T10046 T10043 punct ",",enhanced
R8387 T10047 T10051 mark while,was
R8388 T10048 T10050 det the,content
R8389 T10049 T10050 amod IκB-α,content
R8390 T10050 T10051 nsubj content,was
R8391 T10051 T10043 advcl was,enhanced
R8392 T10052 T10051 neg not,was
R8393 T10053 T10054 advmod significantly,affected
R8394 T10054 T10051 acomp affected,was
R8395 T10055 T10057 punct (,2B
R8396 T10056 T10057 compound Figure,2B
R8397 T10057 T10051 advmod 2B,was
R8398 T10058 T10057 punct ",",2B
R8399 T10059 T10057 appos cytosol,2B
R8400 T10060 T10057 punct ),2B
R8401 T10061 T10043 punct .,enhanced
R8402 T10062 T10063 amod Transient,stimulation
R8403 T10063 T10066 nsubj stimulation,increased
R8404 T10064 T10063 prep with,stimulation
R8405 T10065 T10064 pobj PMA,with
R8406 T10066 T10106 ccomp increased,persisted
R8407 T10067 T10071 det the,activity
R8408 T10068 T10069 compound NF-κB,DNA
R8409 T10069 T10071 nmod DNA,activity
R8410 T10070 T10071 amod binding,activity
R8411 T10071 T10066 dobj activity,increased
R8412 T10072 T10071 cc and,activity
R8413 T10073 T10074 amod nuclear,p65
R8414 T10074 T10071 conj p65,activity
R8415 T10075 T10066 prep at,increased
R8416 T10076 T10077 nummod 5,min
R8417 T10077 T10075 pobj min,at
R8418 T10078 T10066 advcl peaking,increased
R8419 T10079 T10078 prep at,peaking
R8420 T10080 T10079 pobj 60,at
R8421 T10081 T10082 nummod 120,min
R8422 T10082 T10066 npadvmod min,increased
R8423 T10083 T10082 advmod independently,min
R8424 T10084 T10083 prep of,independently
R8425 T10085 T10086 det the,presence
R8426 T10086 T10084 pobj presence,of
R8427 T10087 T10086 prep of,presence
R8428 T10088 T10087 pobj Tat,of
R8429 T10089 T10091 punct (,2A
R8430 T10090 T10091 compound Figure,2A
R8431 T10091 T10086 appos 2A,presence
R8432 T10092 T10091 cc and,2A
R8433 T10093 T10091 conj B,2A
R8434 T10094 T10082 punct ),min
R8435 T10095 T10106 punct ;,persisted
R8436 T10096 T10106 advmod however,persisted
R8437 T10097 T10106 punct ",",persisted
R8438 T10098 T10102 mark while,binding
R8439 T10099 T10101 det the,DNA
R8440 T10100 T10101 nummod p65,DNA
R8441 T10101 T10102 nsubj DNA,binding
R8442 T10102 T10105 amod binding,p65
R8443 T10103 T10102 cc and,binding
R8444 T10104 T10102 conj nuclear,binding
R8445 T10105 T10106 nsubj p65,persisted
R8446 T10106 T10106 ROOT persisted,persisted
R8447 T10107 T10116 advcl elevated,dropped
R8448 T10108 T10107 prep at,elevated
R8449 T10109 T10110 amod 240-min,post-treatment
R8450 T10110 T10108 pobj post-treatment,at
R8451 T10111 T10110 prep in,post-treatment
R8452 T10112 T10113 amod Tat-positive,cells
R8453 T10113 T10111 pobj cells,in
R8454 T10114 T10116 punct ",",dropped
R8455 T10115 T10116 nsubj they,dropped
R8456 T10116 T10106 conj dropped,persisted
R8457 T10117 T10116 prep in,dropped
R8458 T10118 T10119 amod Tat-negative,cells
R8459 T10119 T10117 pobj cells,in
R8460 T10120 T10121 punct (,Figure
R8461 T10121 T10116 npadvmod Figure,dropped
R8462 T10122 T10121 nummod 2A,Figure
R8463 T10123 T10121 cc and,Figure
R8464 T10124 T10121 conj B,Figure
R8465 T10125 T10121 punct ),Figure
R8466 T10126 T10116 punct .,dropped
R8467 T10127 T10131 prep In,bound
R8468 T10128 T10127 pobj addition,In
R8469 T10129 T10131 punct ",",bound
R8470 T10130 T10131 nsubj Tat,bound
R8480 T10140 T10142 poss its,increased
R8481 T10141 T10142 advmod binding,increased
R8482 T10142 T10131 dep increased,bound
R8483 T10143 T10142 prep following,increased
R8484 T10144 T10145 compound PMA,stimulation
R8485 T10145 T10143 pobj stimulation,following
R8486 T10146 T10148 punct (,2A
R8487 T10147 T10148 compound Figure,2A
R8488 T10148 T10145 appos 2A,stimulation
R8489 T10149 T10142 punct ),increased
R8490 T10150 T10131 punct ",",bound
R8491 T10151 T10131 advcl suggesting,bound
R8492 T10152 T10156 mark that,was
R8493 T10153 T10155 det the,protein
R8494 T10154 T10155 amod viral,protein
R8495 T10155 T10156 nsubj protein,was
R8496 T10156 T10151 ccomp was,suggesting
R8497 T10157 T10158 det a,component
R8498 T10158 T10156 attr component,was
R8499 T10159 T10158 prep of,component
R8500 T10160 T10163 det the,bound
R8501 T10161 T10163 amod NF-κB,bound
R8502 T10162 T10163 amod complex,bound
R8503 T10163 T10156 conj bound,was
R8504 T10164 T10163 prep to,bound
R8505 T10165 T10164 pobj DNA,to
R8506 T10166 T10131 punct .,bound
R8507 T10167 T10172 nsubjpass Degradation,induced
R8508 T10168 T10167 prep of,Degradation
R8509 T10169 T10168 pobj IκB-α,of
R8510 T10170 T10172 auxpass was,induced
R8511 T10171 T10172 advmod progressively,induced
R8512 T10172 T10172 ROOT induced,induced
R8513 T10173 T10172 prep at,induced
R8514 T10174 T10173 pobj 5,at
R8515 T10175 T10176 nummod 30,min
R8516 T10176 T10176 ROOT min,min
R8517 T10177 T10176 punct ",",min
R8518 T10178 T10176 acl followed,min
R8519 T10179 T10178 agent by,followed
R8520 T10180 T10182 nmod de,synthesis
R8521 T10181 T10182 amod novo,synthesis
R8522 T10182 T10179 pobj synthesis,by
R8523 T10183 T10182 prep at,synthesis
R8524 T10184 T10185 nummod 60,min
R8525 T10185 T10183 pobj min,at
R8526 T10186 T10178 prep with,followed
R8527 T10187 T10188 amod full,replenishment
R8528 T10188 T10186 pobj replenishment,with
R8529 T10189 T10178 prep at,followed
R8530 T10190 T10191 nummod 240,min
R8531 T10191 T10189 pobj min,at
R8532 T10192 T10191 prep in,min
R8533 T10193 T10194 preconj both,Tat-positive
R8534 T10194 T10197 amod Tat-positive,cells
R8535 T10195 T10194 cc and,Tat-positive
R8536 T10196 T10194 conj negative,Tat-positive
R8537 T10197 T10192 pobj cells,in
R8538 T10198 T10200 punct (,2B
R8539 T10199 T10200 compound Figure,2B
R8540 T10200 T10191 appos 2B,min
R8541 T10201 T10200 punct ",",2B
R8542 T10202 T10200 appos cytosol,2B
R8543 T10203 T10200 punct ),2B
R8545 T10284 T10279 pobj complex,of
R8547 T10285 T10273 punct .,tested
R8549 T10286 T10297 prep To,analysed
R8550 T10287 T10288 det this,end
R8552 T10288 T10286 pobj end,To
R8553 T10289 T10297 punct ",",analysed
R8554 T10290 T10291 det the,association
R8556 T10291 T10297 nsubjpass association,analysed
R8557 T10292 T10291 prep of,association
R8558 T10293 T10292 pobj IκB-α,of
R8560 T10294 T10291 prep with,association
R8561 T10295 T10294 pobj p65,with
R8562 T10296 T10297 auxpass was,analysed
R8564 T10297 T10297 ROOT analysed,analysed
R8565 T10298 T10297 prep in,analysed
R8566 T10299 T10298 pobj vivo,in
R8568 T10300 T10297 prep at,analysed
R8569 T10301 T10304 nummod 0,min
R8571 T10302 T10301 cc and,0
R8572 T10303 T10301 conj 240,0
R8574 T10304 T10300 pobj min,at
R8576 T10305 T10304 prep after,min
R8577 T10306 T10307 amod short-pulse,PMA
R8579 T10307 T10305 pobj PMA,after
R8580 T10308 T10307 punct ",",PMA
R8581 T10309 T10310 nsubj which,corresponded
R8582 T10310 T10307 relcl corresponded,PMA
R8583 T10311 T10310 prep to,corresponded
R8584 T10312 T10313 det the,time
R8586 T10313 T10311 pobj time,to
R8587 T10314 T10313 prep of,time
R8588 T10315 T10316 amod un-stimulated,condition
R8590 T10316 T10314 pobj condition,of
R8591 T10317 T10316 cc and,condition
R8592 T10318 T10316 conj post-activation,condition
R8594 T10319 T10321 nmod de,synthesis
R8595 T10320 T10321 amod novo,synthesis
R8597 T10321 T10316 conj synthesis,condition
R8599 T10322 T10321 prep of,synthesis
R8600 T10323 T10322 pobj IκB-α,of
R8602 T10324 T10307 punct ",",PMA
R8603 T10325 T10297 advmod respectively,analysed
R8605 T10326 T10297 punct .,analysed
R8606 T10327 T10333 nsubjpass Coimmunoprecipitation,detected
R8607 T10328 T10327 prep of,Coimmunoprecipitation
R8609 T10329 T10328 pobj IκB-α,of
R8610 T10330 T10327 prep with,Coimmunoprecipitation
R8611 T10331 T10330 pobj p65,with
R8613 T10332 T10333 auxpass was,detected
R8614 T10333 T10333 ROOT detected,detected
R8615 T10334 T10333 prep at,detected
R8616 T10335 T10334 pobj 0,at
R8617 T10225 T10224 prep of,presence
R8618 T10336 T10333 punct -,detected
R8619 T10337 T10333 cc and,detected
R8620 T10338 T10339 amod 240-min,post-treatment
R8621 T10226 T10225 pobj Tat,of
R8622 T10339 T10347 nsubj post-treatment,lanes
R8623 T10340 T10339 prep in,post-treatment
R8624 T10227 T10228 punct (,Figure
R8625 T10341 T10342 amod Tat-negative,cells
R8626 T10342 T10340 pobj cells,in
R8627 T10343 T10344 punct (,Figure
R8628 T10228 T10226 appos Figure,Tat
R8629 T10344 T10339 appos Figure,post-treatment
R8630 T10345 T10344 nummod 2D,Figure
R8631 T10346 T10344 punct ",",Figure
R8632 T10347 T10347 ROOT lanes,lanes
R8633 T10348 T10347 nummod 1,lanes
R8634 T10349 T10347 cc and,lanes
R8635 T10350 T10347 conj 3,lanes
R8636 T10229 T10224 npadvmod 2C,presence
R8637 T10351 T10350 punct ),3
R8638 T10352 T10347 punct ",",lanes
R8639 T10353 T10333 cc and,detected
R8640 T10230 T10221 punct ),independently
R8641 T10354 T10355 auxpass was,halved
R8642 T10355 T10333 conj halved,detected
R8643 T10231 T10210 punct .,started
R8644 T10356 T10355 prep in,halved
R8645 T10357 T10358 amod Tat-positive,cells
R8646 T10358 T10356 pobj cells,in
R8647 T10232 T10233 det These,results
R8648 T10359 T10355 punct ",",halved
R8649 T10360 T10362 advmod where,coimmunoprecipitated
R8650 T10361 T10362 nsubj Tat,coimmunoprecipitated
R8651 T10233 T10234 nsubj results,indicated
R8652 T10362 T10355 advcl coimmunoprecipitated,halved
R8653 T10363 T10362 prep with,coimmunoprecipitated
R8654 T10364 T10369 nmod IκB-α,lanes
R8655 T10365 T10367 punct (,2D
R8656 T10234 T10234 ROOT indicated,indicated
R8657 T10366 T10367 compound Figure,2D
R8658 T10367 T10364 appos 2D,IκB-α
R8659 T10235 T10237 mark that,enhanced
R8660 T10368 T10367 punct ",",2D
R8661 T10369 T10363 pobj lanes,with
R8662 T10370 T10369 nummod 2,lanes
R8663 T10236 T10237 nsubj Tat,enhanced
R8664 T10371 T10370 cc and,2
R8665 T10372 T10370 conj 4,2
R8666 T10373 T10355 punct ),halved
R8667 T10237 T10234 ccomp enhanced,indicated
R8668 T10374 T10333 punct ",",detected
R8669 T10375 T10333 advcl indicating,detected
R8670 T10376 T10378 mark that,competed
R8671 T10238 T10240 det the,activity
R8672 T10377 T10378 nsubj Tat,competed
R8673 T10378 T10375 ccomp competed,indicating
R8674 T10379 T10381 det the,binding
R8675 T10239 T10240 amod NF-κB,activity
R8676 T10380 T10381 amod IκB-α,binding
R8677 T10240 T10237 dobj activity,enhanced
R8678 T10241 T10240 prep in,activity
R8679 T10381 T10378 dobj binding,competed
R8680 T10382 T10381 prep to,binding
R8681 T10242 T10245 amod un-stimulated,cells
R8682 T10383 T10382 pobj p65,to
R8683 T10243 T10242 cc and,un-stimulated
R8684 T10384 T10333 punct .,detected
R8685 T10244 T10242 conj PMA-stimulated,un-stimulated
R8686 T10245 T10241 pobj cells,in
R8687 T10246 T10237 prep without,enhanced
R8688 T10247 T10246 pcomp affecting,without
R8689 T10248 T10250 det the,activity
R8690 T10249 T10250 compound IKK,activity
R8691 T10250 T10247 dobj activity,affecting
R8692 T10251 T10250 cc and,activity
R8693 T10252 T10253 amod IκB-α,content
R8694 T10253 T10250 conj content,activity
R8695 T10254 T10234 punct .,indicated
R8696 T10255 T10258 mark As,found
R8697 T10256 T10258 nsubj we,found
R8698 T10257 T10258 advmod previously,found
R8699 T10258 T10273 advcl found,tested
R8700 T10259 T10261 mark that,binds
R8701 T10260 T10261 nsubj Tat,binds
R8702 T10261 T10258 ccomp binds,found
R8703 T10262 T10261 prep to,binds
R8704 T10263 T10265 det the,ankyrin
R8705 T10264 T10265 amod sixth,ankyrin
R8706 T10265 T10262 pobj ankyrin,to
R8707 T10266 T10265 prep of,ankyrin
R8708 T10267 T10266 pobj IκB-α,of
R8709 T10268 T10267 punct (,IκB-α
R8710 T10269 T10267 parataxis "50,51",IκB-α
R8711 T10270 T10267 punct ),IκB-α
R8712 T10271 T10273 punct ",",tested
R8713 T10272 T10273 nsubj we,tested
R8714 T10273 T10273 ROOT tested,tested
R8715 T10274 T10276 mark whether,counteracted
R8716 T10275 T10276 nsubj Tat,counteracted
R8717 T10276 T10273 ccomp counteracted,tested
R8718 T10277 T10278 det the,generation
R8719 T10278 T10276 dobj generation,counteracted
R8720 T10279 T10278 prep of,generation
R8721 T10280 T10284 det the,complex
R8722 T10281 T10283 compound IκB-α,NF-κB
R8723 T10282 T10283 compound /,NF-κB
R8724 T10283 T10284 compound NF-κB,complex
R9817 T12077 T12078 nsubj Tat,counteracts
R9818 T12078 T12078 ROOT counteracts,counteracts
R9819 T12079 T12081 det the,inhibition
R9820 T12080 T12081 amod IκB-α,inhibition
R9821 T12081 T12078 dobj inhibition,counteracts
R9822 T12082 T12081 prep of,inhibition
R9823 T12083 T12082 pobj p65,of
R9824 T12084 T12078 prep by,counteracts
R9825 T12085 T12084 pcomp competing,by
R9826 T12086 T12087 det the,repressor
R9827 T12087 T12088 compound repressor,binding
R9828 T12088 T12091 advmod binding,investigated
R9829 T12089 T12091 nsubj We,investigated
R9830 T12090 T12091 advmod further,investigated
R9831 T12091 T12078 conj investigated,counteracts
R9832 T12092 T12094 det the,interaction
R9833 T12093 T12094 amod physical,interaction
R9834 T12094 T12091 dobj interaction,investigated
R9835 T12095 T12094 prep of,interaction
R9836 T12096 T12095 pobj Tat,of
R9837 T12097 T12094 prep with,interaction
R9838 T12098 T12097 pobj IκB-α,with
R9839 T12099 T12097 pcomp using,with
R9840 T12100 T12099 prep in,using
R9841 T12101 T12103 amod vitro,proteins
R9842 T12102 T12103 amod translated,proteins
R9843 T12103 T12100 pobj proteins,in
R9844 T12104 T12099 prep in,using
R9845 T12105 T12106 compound coimmunoprecipitation,assays
R9846 T12106 T12104 pobj assays,in
R9847 T12107 T12078 punct .,counteracts
R9848 T12108 T12115 prep For,used
R9849 T12109 T12108 pcomp mapping,For
R9850 T12110 T12112 det the,domains
R9851 T12111 T12112 compound interaction,domains
R9852 T12112 T12109 dobj domains,mapping
R9853 T12113 T12115 punct ",",used
R9854 T12114 T12115 nsubj we,used
R9855 T12115 T12115 ROOT used,used
R9856 T12116 T12119 det the,mutants
R9857 T12117 T12119 amod following,mutants
R9858 T12118 T12119 compound Tat,mutants
R9859 T12119 T12115 dobj mutants,used
R9860 T12120 T12119 punct :,mutants
R9861 T12121 T12122 compound Tat,T
R9862 T12122 T12119 appos T,mutants
R9863 T12123 T12122 punct ",",T
R9864 T12124 T12122 conj N,T
R9865 T12125 T12124 punct (,N
R9866 T12126 T12124 appos "23,24",N
R9867 T12127 T12124 punct ),N
R9868 T12128 T12131 det A,C
R9869 T12129 T12131 punct ",",C
R9870 T12130 T12131 compound Tat,C
R9871 T12131 T12131 ROOT C,C
R9872 T12132 T12131 punct (,C
R9873 T12133 T12131 appos "22,25,27",C
R9874 T12134 T12131 punct ),C
R9875 T12135 T12142 det A,A
R9876 T12136 T12142 punct ",",A
R9877 T12137 T12138 compound Tat,K
R9878 T12138 T12142 nmod K,A
R9879 T12139 T12138 punct (,K
R9880 T12140 T12138 appos "50,51",K
R9881 T12141 T12142 punct ),A
R9882 T12142 T12142 ROOT A,A
R9883 T12143 T12142 cc and,A
R9884 T12144 T12145 compound Tat,R
R9885 T12145 T12142 conj R,A
R9886 T12146 T12145 punct (,R
R9887 T12147 T12145 appos 49,R
R9888 T12148 T12145 appos 57,R
R9889 T12149 T12145 punct ),R
R9890 T12150 T12153 det A,3A
R9891 T12151 T12153 punct (,3A
R9892 T12152 T12153 compound Figure,3A
R9893 T12153 T12153 ROOT 3A,3A
R9894 T12154 T12153 punct ),3A
R9895 T12155 T12153 punct .,3A
R9896 T12156 T12157 amod IκB-α,coimmunoprecipitated
R9897 T12157 T12157 ROOT coimmunoprecipitated,coimmunoprecipitated
R9898 T12158 T12157 prep with,coimmunoprecipitated
R9899 T12159 T12161 det all,proteins
R9900 T12160 T12161 compound Tat,proteins
R9901 T12161 T12158 pobj proteins,with
R9902 T12162 T12157 punct ",",coimmunoprecipitated
R9903 T12163 T12157 prep except,coimmunoprecipitated
R9904 T12164 T12165 compound Tat,R
R9905 T12165 T12163 pobj R,except
R9906 T12166 T12165 punct (,R
R9907 T12167 T12165 appos 49,R
R9908 T12168 T12165 appos 57,R
R9909 T12169 T12165 punct ),R
R9910 T12170 T12173 det A,3B
R9911 T12171 T12173 punct (,3B
R9912 T12172 T12173 compound Figure,3B
R9913 T12173 T12173 ROOT 3B,3B
R9914 T12174 T12173 punct ),3B
R9915 T12175 T12173 punct .,3B
R9916 T12176 T12177 det These,results
R9917 T12177 T12178 nsubj results,indicated
R9918 T12178 T12178 ROOT indicated,indicated
R9919 T12179 T12186 mark that,involved
R9920 T12180 T12182 det the,domain
R9921 T12181 T12182 amod arginine-rich,domain
R9922 T12182 T12186 nsubjpass domain,involved
R9923 T12183 T12182 prep of,domain
R9924 T12184 T12183 pobj Tat,of
R9925 T12185 T12186 auxpass was,involved
R9926 T12186 T12178 ccomp involved,indicated
R9927 T12187 T12186 prep in,involved
R9928 T12188 T12189 det the,binding
R9929 T12189 T12187 pobj binding,in
R9930 T12190 T12189 prep to,binding
R9931 T12191 T12190 pobj IκB-α,to
R9932 T12192 T12191 punct ",",IκB-α
R9933 T12193 T12194 nsubj which,was
R9934 T12194 T12191 relcl was,IκB-α
R9935 T12195 T12194 acomp consistent,was
R9936 T12196 T12195 prep with,consistent
R9937 T12197 T12198 amod previous,observations
R9938 T12198 T12196 pobj observations,with
R9939 T12199 T12198 punct (,observations
R9940 T12200 T12198 appos "50,51",observations
R9941 T12201 T12198 punct ),observations
R9942 T12202 T12178 punct .,indicated
R9943 T12203 T12209 advmod Moreover,competed
R9944 T12204 T12209 punct ",",competed
R9945 T12205 T12206 nsubj Tat,associating
R9946 T12206 T12209 advcl associating,competed
R9947 T12207 T12206 prep with,associating
R9948 T12208 T12209 nsubj IκB-α,competed
R9949 T12209 T12209 ROOT competed,competed
R9950 T12210 T12211 det the,binding
R9951 T12211 T12209 dobj binding,competed
R9952 T12212 T12211 prep of,binding
R9953 T12213 T12212 pobj IκB-α,of
R9954 T12214 T12215 aux to,p65
R9955 T12215 T12211 advcl p65,binding
R9956 T12216 T12215 prep in,p65
R9957 T12217 T12219 det a,manner
R9958 T12218 T12219 amod dose-dependent,manner
R9959 T12219 T12216 pobj manner,in
R9960 T12220 T12222 punct (,3C
R9961 T12221 T12222 compound Figure,3C
R9962 T12222 T12215 dep 3C,p65
R9963 T12223 T12222 punct ",",3C
R9964 T12224 T12215 dobj lanes,p65
R9965 T12225 T12224 nummod 3,lanes
R9966 T12226 T12224 appos 5,lanes
R9967 T12227 T12209 punct ),competed
R9968 T12228 T12209 punct ",",competed
R9969 T12229 T12231 mark while,R
R9970 T12230 T12231 compound Tat,R
R9971 T12231 T12209 advcl R,competed
R9972 T12232 T12231 punct (,R
R9973 T12233 T12231 nummod 49,R
R9974 T12234 T12233 prep 57,49
R9975 T12235 T12233 punct ),49
R9976 T12236 T12236 ROOT A,A
R9977 T12237 T12236 punct ",",A
R9978 T12238 T12239 nsubj which,lacked
R9979 T12239 T12236 relcl lacked,A
R9980 T12240 T12242 det the,site
R9981 T12241 T12242 amod binding,site
R9982 T12242 T12239 dobj site,lacked
R9983 T12243 T12242 prep for,site
R9984 T12244 T12243 pobj IκB-α,for
R9985 T12245 T12248 punct ",",associate
R9986 T12246 T12248 aux did,associate
R9987 T12247 T12248 neg not,associate
R9988 T12248 T12236 appos associate,A
R9989 T12249 T12248 prep with,associate
R9990 T12250 T12249 pobj IκB-α,with
R9991 T12251 T12248 cc and,associate
R9992 T12252 T12254 aux did,compete
R9993 T12253 T12254 neg not,compete
R9994 T12254 T12248 conj compete,associate
R9995 T12255 T12256 det the,binding
R9996 T12256 T12254 dobj binding,compete
R9997 T12257 T12256 prep of,binding
R9998 T12258 T12257 pobj IκB-α,of
R9999 T12259 T12260 aux to,p65
R10000 T12260 T12256 relcl p65,binding
R10001 T12261 T12263 punct (,3C
R10002 T12262 T12263 compound Figure,3C
R10003 T12263 T12260 appos 3C,p65
R10004 T12264 T12263 punct ",",3C
R10005 T12265 T12263 appos lanes,3C
R10006 T12266 T12265 appos 6,lanes
R10007 T12267 T12265 appos 8,lanes
R10008 T12268 T12265 punct ),lanes
R10009 T12269 T12248 punct .,associate
R10010 T12270 T12273 advmod Next,evaluated
R10011 T12271 T12273 punct ",",evaluated
R10012 T12272 T12273 nsubj we,evaluated
R10013 T12273 T12273 ROOT evaluated,evaluated
R10014 T12274 T12276 mark whether,counteracted
R10015 T12275 T12276 nsubj Tat,counteracted
R10016 T12276 T12273 ccomp counteracted,evaluated
R10017 T12277 T12279 det the,inhibition
R10018 T12278 T12279 compound IκB-α-mediated,inhibition
R10019 T12279 T12276 dobj inhibition,counteracted
R10020 T12280 T12279 prep of,inhibition
R10021 T12281 T12280 pobj p65,of
R10022 T12282 T12276 oprd binding,counteracted
R10023 T12283 T12282 prep to,binding
R10024 T12284 T12283 pobj DNA,to
R10025 T12285 T12276 prep by,counteracted
R10026 T12286 T12285 pcomp incubating,by
R10027 T12287 T12286 prep in,incubating
R10028 T12288 T12290 amod vitro,p65
R10029 T12289 T12290 amod translated,p65
R10030 T12290 T12287 pobj p65,in
R10031 T12291 T12290 cc and,p65
R10032 T12292 T12293 amod IκB-α,proteins
R10033 T12293 T12290 conj proteins,p65
R10034 T12294 T12290 prep with,p65
R10035 T12295 T12297 det the,probe
R10036 T12296 T12297 compound NF-κB,probe
R10037 T12297 T12294 pobj probe,with
R10038 T12298 T12297 prep in,probe
R10039 T12299 T12298 pobj presence,in
R10040 T12300 T12299 cc or,presence
R10041 T12301 T12299 conj absence,presence
R10042 T12302 T12301 prep of,absence
R10043 T12303 T12302 pobj Tat,of
R10044 T12304 T12285 acl followed,by
R10045 T12305 T12304 agent by,followed
R10046 T12306 T12305 pobj EMSA,by
R10047 T12307 T12273 punct .,evaluated
R10048 T12308 T12312 det The,activity
R10049 T12309 T12310 nummod p65,DNA
R10050 T12310 T12312 nmod DNA,activity
R10051 T12311 T12312 amod binding,activity
R10052 T12312 T12314 nsubjpass activity,inhibited
R10053 T12313 T12314 auxpass was,inhibited
R10054 T12314 T12314 ROOT inhibited,inhibited
R10055 T12315 T12314 agent by,inhibited
R10056 T12316 T12315 pobj IκB-α,by
R10057 T12317 T12314 cc and,inhibited
R10058 T12318 T12314 conj restored,inhibited
R10059 T12319 T12318 prep in,restored
R10060 T12320 T12322 det a,manner
R10061 T12321 T12322 amod dose-dependent,manner
R10062 T12322 T12319 pobj manner,in
R10063 T12323 T12318 agent by,restored
R10064 T12324 T12325 amod wild-type,Tat
R10065 T12325 T12323 pobj Tat,by
R10066 T12326 T12318 punct ",",restored
R10067 T12327 T12314 cc and,inhibited
R10068 T12328 T12329 neg not,by
R10069 T12329 T12314 conj by,inhibited
R10070 T12330 T12331 compound Tat,R
R10071 T12331 T12329 pobj R,by
R10072 T12332 T12331 punct (,R
R10073 T12333 T12331 appos 49,R
R10074 T12334 T12331 appos 57,R
R10075 T12335 T12331 punct ),R
R10076 T12336 T12338 punct (,3D
R10077 T12337 T12338 compound Figure,3D
R10078 T12338 T12331 appos 3D,R
R10079 T12339 T12329 punct ),by
R10080 T12340 T12314 punct .,inhibited
R10081 T12341 T12344 advmod Further,analysed
R10082 T12342 T12344 punct ",",analysed
R10083 T12343 T12344 nsubj we,analysed
R10084 T12344 T12344 ROOT analysed,analysed
R10085 T12345 T12347 det the,effect
R10086 T12346 T12347 compound Tat,effect
R10087 T12347 T12344 dobj effect,analysed
R10088 T12348 T12347 prep on,effect
R10089 T12349 T12351 det the,repression
R10090 T12350 T12351 amod IκB-α,repression
R10091 T12351 T12348 pobj repression,on
R10092 T12352 T12351 prep of,repression
R10093 T12353 T12355 nummod p65,activity
R10094 T12354 T12355 amod transcriptional,activity
R10095 T12355 T12352 pobj activity,of
R10096 T12356 T12344 prep by,analysed
R10097 T12357 T12356 pcomp transfecting,by
R10098 T12358 T12359 nummod p50,−
R10099 T12359 T12366 nmod −,MEFs
R10100 T12360 T12366 nmod /,MEFs
R10101 T12361 T12366 nmod −,MEFs
R10102 T12362 T12366 nmod p65,MEFs
R10103 T12363 T12366 nmod −,MEFs
R10104 T12364 T12366 nmod /,MEFs
R10105 T12365 T12366 nmod −,MEFs
R10106 T12366 T12357 dobj MEFs,transfecting
R10107 T12367 T12357 prep with,transfecting
R10108 T12368 T12370 det the,reporter
R10109 T12369 T12370 amod NF-κB-Luc,reporter
R10110 T12370 T12367 pobj reporter,with
R10111 T12371 T12357 advmod together,transfecting
R10112 T12372 T12357 prep with,transfecting
R10113 T12373 T12374 compound expression,vectors
R10114 T12374 T12372 pobj vectors,with
R10115 T12375 T12374 prep of,vectors
R10116 T12376 T12375 pobj p65,of
R10117 T12377 T12376 cc and,p65
R10118 T12378 T12376 conj IκB-α,p65
R10119 T12379 T12344 punct ",",analysed
R10120 T12380 T12344 prep in,analysed
R10121 T12381 T12380 pobj presence,in
R10122 T12382 T12381 cc or,presence
R10123 T12383 T12381 conj absence,presence
R10124 T12384 T12383 prep of,absence
R10125 T12385 T12384 pobj Tat,of
R10126 T12386 T12344 punct .,analysed
R10127 T12387 T12388 nsubj IκB-α,inhibited
R10128 T12388 T12388 ROOT inhibited,inhibited
R10129 T12389 T12391 det the,expression
R10130 T12390 T12391 amod p65-dependent,expression
R10131 T12391 T12388 dobj expression,inhibited
R10132 T12392 T12391 prep of,expression
R10133 T12393 T12395 det the,gene
R10134 T12394 T12395 compound luciferase,gene
R10135 T12395 T12392 pobj gene,of
R10136 T12396 T12395 punct ",",gene
R10137 T12397 T12399 nsubjpass which,restored
R10138 T12398 T12399 auxpass was,restored
R10139 T12399 T12395 relcl restored,gene
R10140 T12400 T12399 prep in,restored
R10141 T12401 T12403 det a,manner
R10142 T12402 T12403 amod dose-dependent,manner
R10143 T12403 T12400 pobj manner,in
R10144 T12404 T12399 agent by,restored
R10145 T12405 T12406 amod wild-type,Tat
R10146 T12406 T12404 pobj Tat,by
R10147 T12407 T12399 punct ",",restored
R10148 T12408 T12399 cc and,restored
R10149 T12409 T12410 neg not,by
R10150 T12410 T12399 conj by,restored
R10151 T12411 T12412 compound Tat,R
R10152 T12412 T12410 pobj R,by
R10153 T12413 T12412 punct (,R
R10154 T12414 T12412 appos 49,R
R10155 T12415 T12412 appos 57,R
R10156 T12416 T12412 punct ),R
R10157 T12417 T12419 det A,Figure
R10158 T12418 T12419 punct (,Figure
R10159 T12419 T12419 ROOT Figure,Figure
R10160 T12420 T12419 nummod 3E,Figure
R10161 T12421 T12419 punct ),Figure
R10162 T12422 T12419 punct .,Figure
R10163 T12423 T12426 advmod Altogether,indicated
R10164 T12424 T12425 det these,results
R10165 T12425 T12426 nsubj results,indicated
R10166 T12426 T12426 ROOT indicated,indicated
R10167 T12427 T12429 mark that,counteracts
R10168 T12428 T12429 nsubj Tat,counteracts
R10169 T12429 T12426 ccomp counteracts,indicated
R10170 T12430 T12432 det the,repression
R10171 T12431 T12432 amod IκB-α,repression
R10172 T12432 T12429 dobj repression,counteracts
R10173 T12433 T12432 prep of,repression
R10174 T12434 T12436 det the,DNA-binding
R10175 T12435 T12436 nummod p65,DNA-binding
R10176 T12436 T12433 pobj DNA-binding,of
R10177 T12437 T12436 cc and,DNA-binding
R10178 T12438 T12436 conj transcriptional,DNA-binding
R10179 T12439 T12436 conj activity,DNA-binding
R10180 T12440 T12429 prep by,counteracts
R10181 T12441 T12440 pcomp associating,by
R10182 T12442 T12441 prep with,associating
R10183 T12443 T12442 pobj IκB-α,with
R10184 T12444 T12441 cc and,associating
R10185 T12445 T12441 conj competing,associating
R10186 T12446 T12447 det the,repressor
R10187 T12447 T12448 nsubj repressor,binding
R10188 T12448 T12445 ccomp binding,competing
R10189 T12449 T12448 prep to,binding
R10190 T12450 T12449 pobj p65,to
R10191 T12451 T12426 punct .,indicated
R11150 T13857 T13858 nsubj Tat,increases
R11151 T13858 T13858 ROOT increases,increases
R11152 T13859 T13861 det the,affinity
R11153 T13860 T13861 nummod p65,affinity
R11154 T13861 T13858 dobj affinity,increases
R11155 T13862 T13861 amod binding,affinity
R11156 T13863 T13862 prep to,binding
R11157 T13864 T13863 pobj DNA,to
R11158 T13865 T13858 prep through,increases
R11159 T13866 T13865 pobj association,through
R11160 T13867 T13858 prep with,increases
R11161 T13868 T13867 pobj p65,with
R11162 T13869 T13870 nsubj We,tested
R11163 T13870 T13858 conj tested,increases
R11164 T13871 T13874 mark whether,interacted
R11165 T13872 T13874 nsubj Tat,interacted
R11166 T13873 T13874 advmod physically,interacted
R11167 T13874 T13870 ccomp interacted,tested
R11168 T13875 T13874 prep with,interacted
R11169 T13876 T13875 pobj p65,with
R11170 T13877 T13870 punct .,tested
R11171 T13878 T13879 compound HeLa,cells
R11172 T13879 T13881 nsubjpass cells,transfected
R11173 T13880 T13881 auxpass were,transfected
R11174 T13881 T13881 ROOT transfected,transfected
R11175 T13882 T13881 prep with,transfected
R11176 T13883 T13885 det the,vectors
R11177 T13884 T13885 compound expression,vectors
R11178 T13885 T13882 pobj vectors,with
R11179 T13886 T13885 prep of,vectors
R11180 T13887 T13886 pobj HA-p65,of
R11181 T13888 T13887 cc and,HA-p65
R11182 T13889 T13887 conj FLAG-Tat,HA-p65
R11183 T13890 T13889 punct ",",FLAG-Tat
R11184 T13891 T13885 cc and,vectors
R11185 T13892 T13893 nummod 24,h
R11186 T13893 T13895 compound h,Tat
R11187 T13894 T13895 amod later,Tat
R11188 T13895 T13885 conj Tat,vectors
R11189 T13896 T13897 auxpass was,immunoprecipitated
R11190 T13897 T13881 conj immunoprecipitated,transfected
R11191 T13898 T13897 prep from,immunoprecipitated
R11192 T13899 T13900 compound cell,extracts
R11193 T13900 T13898 pobj extracts,from
R11194 T13901 T13881 punct .,transfected
R11195 T13902 T13904 det The,protein
R11196 T13903 T13904 nummod p65,protein
R11197 T13904 T13906 nsubjpass protein,coimmunoprecipitated
R11198 T13905 T13906 auxpass was,coimmunoprecipitated
R11199 T13906 T13906 ROOT coimmunoprecipitated,coimmunoprecipitated
R11200 T13907 T13906 prep with,coimmunoprecipitated
R11201 T13908 T13909 amod wild-type,Tat
R11202 T13909 T13907 pobj Tat,with
R11203 T13910 T13909 cc or,Tat
R11204 T13911 T13912 det the,mutants
R11205 T13912 T13909 conj mutants,Tat
R11206 T13913 T13914 compound Tat,T
R11207 T13914 T13914 ROOT T,T
R11208 T13915 T13914 punct ",",T
R11209 T13916 T13914 conj N,T
R11210 T13917 T13916 punct (,N
R11211 T13918 T13916 parataxis "23,24",N
R11212 T13919 T13916 punct ),N
R11213 T13920 T13927 det A,A
R11214 T13921 T13927 punct ",",A
R11215 T13922 T13923 compound Tat,K
R11216 T13923 T13927 nmod K,A
R11217 T13924 T13923 punct (,K
R11218 T13925 T13923 appos "50,51",K
R11219 T13926 T13927 punct ),A
R11278 T13996 T13994 conj N,T
R11279 T13997 T13996 punct (,N
R11280 T13998 T13996 appos "23,24",N
R11281 T13999 T13996 punct ),N
R11282 T14000 T14007 det A,A
R11283 T14001 T14007 punct ",",A
R11284 T14002 T14003 compound Tat,K
R11285 T14003 T14007 nmod K,A
R11286 T14004 T14003 punct (,K
R11287 T14005 T14003 appos "50,51",K
R11288 T14006 T14007 punct ),A
R11289 T14007 T14007 ROOT A,A
R11290 T14008 T14007 cc and,A
R11291 T14009 T14010 compound Tat,R
R11292 T14010 T14007 conj R,A
R11293 T14011 T14010 punct (,R
R11294 T14012 T14010 appos 49,R
R11295 T14013 T14010 appos 57,R
R11296 T14014 T14010 punct ),R
R11297 T14015 T14015 ROOT A,A
R11298 T14016 T14015 punct ",",A
R11299 T14017 T14015 cc and,A
R11300 T14018 T14020 nsubj lack,binding
R11301 T14019 T14020 advmod of,binding
R11302 T14020 T14015 conj binding,A
R11303 T14021 T14020 prep to,binding
R11304 T14022 T14023 compound Tat,C
R11305 T14023 T14021 pobj C,to
R11306 T14024 T14023 punct (,C
R11307 T14025 T14023 appos "22,25,27",C
R11308 T14026 T14023 punct ),C
R11309 T14027 T14030 det A,4B
R11310 T14028 T14030 punct (,4B
R11311 T14029 T14030 compound Figure,4B
R11312 T14030 T14030 ROOT 4B,4B
R11313 T14031 T14030 punct ),4B
R11314 T14032 T14030 punct .,4B
R11315 T14033 T14034 det These,results
R11316 T14034 T14035 nsubj results,indicated
R11317 T14035 T14035 ROOT indicated,indicated
R11318 T14036 T14038 mark that,associated
R11339 T14057 T14058 aux To,identify
R11340 T14058 T14071 advcl identify,transfected
R11341 T14059 T14061 det the,domain
R11342 T14060 T14061 compound p65,domain
R11343 T14061 T14058 dobj domain,identify
R11344 T14062 T14061 acl required,domain
R11345 T14063 T14062 prep for,required
R11346 T14064 T14071 advcl binding,transfected
R11347 T14065 T14064 prep to,binding
R11348 T14066 T14065 pobj Tat,to
R11349 T14067 T14071 punct ",",transfected
R11350 T14068 T14069 compound HeLa,cells
R11351 T14069 T14071 nsubjpass cells,transfected
R11352 T14070 T14071 auxpass were,transfected
R11353 T14071 T14071 ROOT transfected,transfected
R11354 T14072 T14071 prep with,transfected
R11355 T14073 T14072 pobj FLAG-Tat,with
R11356 T14074 T14075 advmod together,with
R11357 T14075 T14073 prep with,FLAG-Tat
R11358 T14076 T14077 amod HA-p65,mutants
R11359 T14077 T14075 pobj mutants,with
R11360 T14078 T14077 punct ",",mutants
R11361 T14079 T14081 nsubjpass which,deleted
R11362 T14080 T14081 auxpass were,deleted
R11363 T14081 T14077 relcl deleted,mutants
R11364 T14082 T14081 prep of,deleted
R11365 T14083 T14085 det the,domain
R11366 T14084 T14085 compound transactivation,domain
R11367 T14085 T14082 pobj domain,of
R11368 T14086 T14087 compound [,p65ΔC
R11369 T14087 T14085 appos p65ΔC,domain
R11370 T14088 T14089 punct (,1
R11371 T14089 T14087 parataxis 1,p65ΔC
R11372 T14090 T14085 appos 318,domain
R11373 T14091 T14071 punct ),transfected
R11374 T14092 T14092 ROOT ],]
R11375 T14093 T14092 punct ",",]
R11376 T14094 T14092 cc or,]
R11377 T14095 T14098 det the,p65ΔN
R11378 T14096 T14098 compound RHD,p65ΔN
R11379 T14097 T14098 compound [,p65ΔN
R11380 T14098 T14092 conj p65ΔN,]
R11381 T14099 T14098 punct (,p65ΔN
R11382 T14100 T14101 dep 122,551
R11383 T14101 T14098 appos 551,p65ΔN
R11384 T14102 T14098 punct ),p65ΔN
R11385 T14103 T14103 ROOT ],]
R11386 T14104 T14106 punct (,4C
R11387 T14105 T14106 compound Figure,4C
R11388 T14106 T14103 appos 4C,]
R11389 T14107 T14106 punct ),4C
R11390 T14108 T14103 punct .,]
R11391 T14109 T14110 nsubj Tat,coimmunoprecipitated
R11392 T14110 T14110 ROOT coimmunoprecipitated,coimmunoprecipitated
R11393 T14111 T14110 prep with,coimmunoprecipitated
R11394 T14112 T14111 pobj p65ΔC,with
R11395 T14113 T14114 punct (,1
R11396 T14114 T14112 nummod 1,p65ΔC
R11405 T14123 T14124 dep 122,551
R11406 T14124 T14121 appos 551,p65ΔN
R11407 T14125 T14121 punct ),p65ΔN
R11408 T14126 T14127 punct (,Figure
R11409 T14127 T14120 appos Figure,with
R11410 T14128 T14127 nummod 4D,Figure
R11411 T14129 T14127 punct ),Figure
R11412 T14130 T14131 punct ",",indicating
R11413 T14131 T14110 conj indicating,coimmunoprecipitated
R11414 T14132 T14138 mark that,involved
R11415 T14133 T14134 det the,RHD
R11416 T14134 T14138 nsubjpass RHD,involved
R11417 T14135 T14134 prep of,RHD
R11418 T14136 T14135 pobj p65,of
R11419 T14137 T14138 auxpass was,involved
R11420 T14138 T14131 ccomp involved,indicating
R11421 T14139 T14138 prep in,involved
R11422 T14140 T14142 det the,interaction
R11423 T14141 T14142 amod physical,interaction
R11424 T14142 T14139 pobj interaction,in
R11425 T14143 T14142 prep with,interaction
R11426 T14144 T14143 pobj Tat,with
R11427 T14145 T14110 punct .,coimmunoprecipitated
R11428 T14146 T14147 aux To,address
R11429 T14147 T14158 advcl address,purified
R11430 T14148 T14149 det the,effect
R11431 T14149 T14147 dobj effect,address
R11432 T14150 T14149 prep of,effect
R11433 T14151 T14150 pobj Tat,of
R11441 T14159 T14161 amod recombinant,protein
R11442 T14160 T14161 compound p65,protein
R11443 T14161 T14163 nsubjpass protein,incubated
R11444 T14162 T14163 auxpass was,incubated
R11445 T14163 T14163 ROOT incubated,incubated
R11446 T14164 T14163 prep with,incubated
R11447 T14165 T14167 amod 32P-labeled-NF-κB,oligonucleotide
R11448 T14166 T14167 amod double-stranded,oligonucleotide
R11449 T14167 T14164 pobj oligonucleotide,with
R11450 T14168 T14167 prep in,oligonucleotide
R11451 T14169 T14168 pobj presence,in
R11452 T14170 T14169 cc or,presence
R11453 T14171 T14169 conj absence,presence
R11454 T14172 T14171 prep of,absence
R11455 T14173 T14174 amod wild-type,Tat
R11456 T14174 T14172 pobj Tat,of
R11457 T14175 T14174 cc or,Tat
R11458 T14176 T14177 compound Tat,C
R11459 T14177 T14174 conj C,Tat
R11460 T14178 T14177 punct (,C
R11461 T14179 T14177 appos "22,25,27",C
R11462 T14180 T14177 punct ),C
R11463 T14181 T14187 nsubjpass A,analysed
R11464 T14182 T14181 punct ",",A
R11465 T14183 T14181 cc and,A
R11466 T14184 T14185 nummod p65,DNA-binding
R11467 T14185 T14186 nsubj DNA-binding,was
R11491 T14209 T14206 punct ),C
R11492 T14210 T14219 intj A,was
R11493 T14211 T14219 punct ",",was
R11494 T14212 T14219 advcl lacking,was
R11495 T14213 T14215 det the,site
R11496 T14214 T14215 amod binding,site
R11497 T14215 T14212 dobj site,lacking
R11498 T14216 T14215 prep for,site
R11499 T14217 T14216 pobj p65,for
R11500 T14218 T14219 punct ",",was
R11501 T14219 T14219 ROOT was,was
R11502 T14220 T14219 acomp ineffective,was
R11503 T14221 T14222 punct (,Figure
R11504 T14222 T14219 npadvmod Figure,was
R11505 T14223 T14222 nummod 4E,Figure
R11506 T14224 T14222 punct ),Figure
R11507 T14225 T14219 punct .,was
R11508 T14226 T14227 det The,p65
R11509 T14227 T14228 nsubj p65,binding
R11510 T14228 T14232 nsubjpass binding,evaluated
R11511 T14229 T14228 prep to,binding
R11512 T14230 T14229 pobj DNA,to
R11513 T14231 T14232 auxpass was,evaluated
R11514 T14232 T14232 ROOT evaluated,evaluated
R11515 T14233 T14232 agent by,evaluated
R11516 T14234 T14233 pobj competition,by
R11517 T14235 T14234 prep with,competition
R11518 T14236 T14237 amod increasing,amounts
R11519 T14237 T14235 pobj amounts,with
R11520 T14238 T14237 prep of,amounts
R11521 T14239 T14240 amod cold,competitor
R11522 T14240 T14242 compound competitor,oligonucleotide
R11523 T14241 T14242 compound NF-κB,oligonucleotide
R11524 T14242 T14238 pobj oligonucleotide,of
R11525 T14243 T14242 punct ",",oligonucleotide
R11526 T14244 T14245 nsubj which,showed
R11527 T14245 T14242 relcl showed,oligonucleotide
R11528 T14246 T14249 mark that,enhanced
R11529 T14247 T14249 nsubj Tat,enhanced
R11530 T14248 T14249 advmod significantly,enhanced
R11531 T14249 T14245 ccomp enhanced,showed
R11532 T14250 T14253 det the,binding
R11533 T14251 T14252 nummod p65,affinity
R11544 T14262 T14232 punct .,evaluated
R12788 T15998 T15999 nsubj Tat,activates
R12789 T15999 T15999 ROOT activates,activates
R12790 T16000 T16002 det the,expression
R12791 T16001 T16002 amod p65-dependent,expression
R12792 T16002 T15999 dobj expression,activates
R12793 T16003 T16002 prep of,expression
R12794 T16004 T16005 amod NF-κB-responsive,genes
R12795 T16005 T16003 pobj genes,of
R12796 T16006 T15999 punct ",",activates
R12797 T16007 T15999 conj occupies,activates
R12798 T16008 T16010 det the,enhancers
R12799 T16009 T16010 amod NF-κB,enhancers
R12800 T16010 T16007 dobj enhancers,occupies
R12801 T16011 T16007 cc and,occupies
R12802 T16012 T16007 conj promotes,occupies
R12803 T16013 T16015 det the,recruitment
R12804 T16014 T16015 nummod p65,recruitment
R12805 T16015 T16012 dobj recruitment,promotes
R12806 T16016 T16012 prep with,promotes
R12807 T16017 T16018 amod IκB-α,displacement
R12808 T16018 T16016 pobj displacement,with
R12809 T16019 T16020 nsubj We,analysed
R12810 T16020 T16012 conj analysed,promotes
R12811 T16021 T16022 det the,action
R12812 T16022 T16020 dobj action,analysed
R12813 T16023 T16022 prep of,action
R12814 T16024 T16023 pobj Tat,of
R12815 T16025 T16022 prep on,action
R12816 T16026 T16027 det the,expression
R12817 T16027 T16025 pobj expression,on
R12818 T16028 T16027 prep of,expression
R12819 T16029 T16030 amod NF-κB-responsive,genes
R12820 T16030 T16028 pobj genes,of
R12821 T16031 T16020 prep in,analysed
R12822 T16032 T16031 pobj vivo,in
R12823 T16033 T15999 punct .,activates
R12824 T16034 T16041 prep To,transfected
R12825 T16035 T16036 det this,end
R12826 T16036 T16034 pobj end,To
R12827 T16037 T16041 punct ",",transfected
R12828 T16038 T16039 compound HeLa,cells
R12829 T16039 T16041 nsubjpass cells,transfected
R12830 T16040 T16041 auxpass were,transfected
R12831 T16041 T16041 ROOT transfected,transfected
R12832 T16042 T16041 prep with,transfected
R12833 T16043 T16042 pobj FLAG-Tat,with
R12834 T16044 T16043 punct ",",FLAG-Tat
R12835 T16045 T16046 compound FLAG-Tat,C
R12836 T16046 T16043 conj C,FLAG-Tat
R12837 T16047 T16046 punct (,C
R12838 T16048 T16046 appos "22,25,27",C
R12839 T16049 T16046 punct ),C
R12840 T16050 T16053 det A,R
R12841 T16051 T16052 cc or,FLAG-Tat
R12842 T16052 T16053 compound FLAG-Tat,R
R12843 T16053 T16053 ROOT R,R
R12844 T16054 T16053 punct (,R
R12845 T16055 T16053 appos 49,R
R12846 T16056 T16053 appos 57,R
R12847 T16057 T16053 punct ),R
R12848 T16058 T16062 det A,h
R12849 T16059 T16058 punct ",",A
R12850 T16060 T16058 cc and,A
R12851 T16061 T16062 nummod 48,h
R12852 T16062 T16063 npadvmod h,later
R12853 T16063 T16073 advmod later,analysed
R12854 T16064 T16065 det the,expression
R12855 T16065 T16073 nsubjpass expression,analysed
R12856 T16066 T16065 prep of,expression
R12857 T16067 T16068 det a,number
R12858 T16068 T16066 pobj number,of
R12859 T16069 T16068 prep of,number
R12860 T16070 T16071 amod NF-κB-dependent,genes
R12861 T16071 T16069 pobj genes,of
R12862 T16072 T16073 auxpass was,analysed
R12863 T16073 T16073 ROOT analysed,analysed
R12864 T16074 T16073 agent by,analysed
R12865 T16075 T16076 amod real-time,PCR
R12866 T16076 T16074 pobj PCR,by
R12867 T16077 T16073 punct .,analysed
R12868 T16078 T16080 nsubj Tat,increased
R12869 T16079 T16080 advmod significantly,increased
R12870 T16080 T16080 ROOT increased,increased
R12871 T16081 T16082 det the,expression
R12872 T16082 T16080 dobj expression,increased
R12873 T16083 T16082 prep of,expression
R12874 T16084 T16083 pobj MIP-1α,of
R12875 T16085 T16084 punct ",",MIP-1α
R12876 T16086 T16084 conj CSF3,MIP-1α
R12877 T16087 T16086 punct ",",CSF3
R12878 T16088 T16086 conj LTA,CSF3
R12879 T16089 T16088 punct ",",LTA
R12880 T16090 T16088 conj NFKBIA,LTA
R12881 T16091 T16090 cc and,NFKBIA
R12882 T16092 T16090 conj TLR2,NFKBIA
R12883 T16093 T16080 punct ",",increased
R12884 T16094 T16080 prep while,increased
R12885 T16095 T16096 det the,mutants
R12886 T16096 T16094 pobj mutants,while
R12887 T16097 T16098 compound Tat,C
R12888 T16098 T16096 appos C,mutants
R12889 T16099 T16100 punct (,"22,25,27"
R12890 T16100 T16098 parataxis "22,25,27",C
R12891 T16101 T16102 punct ),A
R12892 T16102 T16096 appos A,mutants
R12893 T16103 T16102 cc and,A
R12894 T16104 T16105 compound Tat,R
R12895 T16105 T16102 conj R,A
R12896 T16106 T16105 punct (,R
R12897 T16107 T16105 appos 49,R
R12898 T16108 T16105 appos 57,R
R12899 T16109 T16105 punct ),R
R12900 T16110 T16111 nsubj A,were
R12901 T16111 T16111 ROOT were,were
R12902 T16112 T16111 acomp ineffective,were
R12903 T16113 T16114 punct (,Figure
R12904 T16114 T16111 parataxis Figure,were
R12905 T16115 T16114 nummod 5A,Figure
R12906 T16116 T16114 appos E,Figure
R12907 T16117 T16114 punct ),Figure
R12908 T16118 T16111 punct .,were
R12909 T16119 T16121 det The,transactivation
R12910 T16120 T16121 amod Tat-dependent,transactivation
R12911 T16121 T16127 nsubjpass transactivation,abolished
R12912 T16122 T16121 prep of,transactivation
R12913 T16123 T16125 det the,genes
R12914 T16124 T16125 amod NF-κB-dependent,genes
R12915 T16125 T16122 pobj genes,of
R12916 T16126 T16127 auxpass was,abolished
R12917 T16127 T16127 ROOT abolished,abolished
R12918 T16128 T16131 advmod when,transfected
R12919 T16129 T16131 nsubjpass cells,transfected
R12920 T16130 T16131 auxpass were,transfected
R12921 T16131 T16127 advcl transfected,abolished
R12922 T16132 T16131 prep with,transfected
R12923 T16133 T16134 compound siRNA,p65
R12924 T16134 T16132 pobj p65,with
R12925 T16135 T16127 punct ",",abolished
R12926 T16136 T16127 advcl indicating,abolished
R12927 T16137 T16143 mark that,mediated
R12928 T16138 T16141 det the,activation
R12929 T16139 T16141 nmod Tat,activation
R12930 T16140 T16141 amod transcriptional,activation
R12931 T16141 T16143 nsubjpass activation,mediated
R12932 T16142 T16143 auxpass was,mediated
R12933 T16143 T16136 ccomp mediated,indicating
R12934 T16144 T16143 agent by,mediated
R12935 T16145 T16144 pobj p65,by
R12936 T16146 T16147 punct (,Figure
R12937 T16147 T16145 appos Figure,p65
R12938 T16148 T16147 nummod 5A,Figure
R12939 T16149 T16147 appos E,Figure
R12940 T16150 T16147 punct ),Figure
R12941 T16151 T16127 punct .,abolished
R12942 T16152 T16164 advmod Differently,unaffected
R12943 T16153 T16164 punct ",",unaffected
R12944 T16154 T16155 det the,expression
R12945 T16155 T16164 nsubjpass expression,unaffected
R12946 T16156 T16155 prep of,expression
R12947 T16157 T16159 det the,genes
R12948 T16158 T16159 amod NF-κB-independent,genes
R12949 T16159 T16156 pobj genes,of
R12950 T16160 T16155 appos GAPDH,expression
R12951 T16161 T16160 cc and,GAPDH
R12952 T16162 T16160 conj ACTB,GAPDH
R12953 T16163 T16164 auxpass was,unaffected
R12954 T16164 T16164 ROOT unaffected,unaffected
R12955 T16165 T16164 agent by,unaffected
R12956 T16166 T16165 pobj wild-type,by
R12957 T16167 T16166 cc and,wild-type
R12958 T16168 T16166 conj Tat,wild-type
R12959 T16169 T16166 conj mutants,wild-type
R12960 T16170 T16171 punct (,Figure
R12961 T16171 T16169 appos Figure,mutants
R12962 T16172 T16171 nummod 5F,Figure
R12963 T16173 T16171 cc and,Figure
R12964 T16174 T16171 conj G,Figure
R12965 T16175 T16169 punct ),mutants
R12966 T16176 T16164 punct .,unaffected
R12967 T16177 T16178 det These,results
R12968 T16178 T16179 nsubj results,were
R12969 T16179 T16179 ROOT were,were
R12970 T16180 T16179 acomp consistent,were
R12971 T16181 T16180 prep with,consistent
R12972 T16182 T16183 det the,requirement
R12973 T16183 T16181 pobj requirement,with
R12974 T16184 T16183 prep of,requirement
R12975 T16185 T16187 preconj both,cysteine-rich
R12976 T16186 T16187 det the,cysteine-rich
R12977 T16187 T16184 pobj cysteine-rich,of
R12978 T16188 T16187 cc and,cysteine-rich
R12979 T16189 T16190 amod arginine-rich,domains
R12980 T16190 T16187 conj domains,cysteine-rich
R12981 T16191 T16190 prep of,domains
R12982 T16192 T16191 pobj Tat,of
R12983 T16193 T16194 aux to,enhance
R12984 T16194 T16179 xcomp enhance,were
R12985 T16195 T16197 det the,activity
R12986 T16196 T16197 compound NF-κB,activity
R12987 T16197 T16194 dobj activity,enhance
R12988 T16198 T16179 punct ",",were
R12989 T16199 T16179 advcl suggesting,were
R12990 T16200 T16209 mark that,occur
R12991 T16201 T16202 det the,up-regulation
R12992 T16202 T16209 nsubj up-regulation,occur
R12993 T16203 T16202 prep of,up-regulation
R12994 T16204 T16205 amod NF-κB-responsive,genes
R12995 T16205 T16203 pobj genes,of
R12996 T16206 T16202 prep by,up-regulation
R12997 T16207 T16206 pobj Tat,by
R12998 T16208 T16209 aux might,occur
R12999 T16209 T16199 ccomp occur,suggesting
R13000 T16210 T16209 prep through,occur
R13001 T16211 T16212 amod physical,interaction
R13002 T16212 T16210 pobj interaction,through
R13003 T16213 T16212 prep of,interaction
R13004 T16214 T16216 det the,protein
R13005 T16215 T16216 amod viral,protein
R13006 T16216 T16213 pobj protein,of
R13007 T16217 T16212 prep with,interaction
R13008 T16218 T16217 pobj p65,with
R13009 T16219 T16218 cc and,p65
R13010 T16220 T16218 conj IκB-α,p65
R13011 T16221 T16179 punct .,were
R13012 T16222 T16233 nsubj MIP-1α,encodes
R13013 T16223 T16222 punct ",",MIP-1α
R13014 T16224 T16225 nsubj which,was
R13015 T16225 T16222 relcl was,MIP-1α
R13016 T16226 T16229 det the,gene
R13017 T16227 T16228 advmod mostly,activated
R13018 T16228 T16229 amod activated,gene
R13019 T16229 T16225 attr gene,was
R13020 T16230 T16229 prep by,gene
R13021 T16231 T16230 pobj Tat,by
R13022 T16232 T16222 punct ",",MIP-1α
R13023 T16233 T16233 ROOT encodes,encodes
R13024 T16234 T16233 prep for,encodes
R13025 T16235 T16236 det a,chemokine
R13026 T16236 T16234 pobj chemokine,for
R13027 T16237 T16238 nsubj that,promotes
R13028 T16238 T16236 relcl promotes,chemokine
R13029 T16239 T16240 det the,recruitment
R13030 T16240 T16238 dobj recruitment,promotes
R13031 T16241 T16240 prep of,recruitment
R13032 T16242 T16243 amod pro-inflammatory,cells
R13033 T16243 T16241 pobj cells,of
R13034 T16244 T16245 punct (,56
R13035 T16245 T16238 npadvmod 56,promotes
R13036 T16246 T16236 punct ),chemokine
R13037 T16247 T16233 punct .,encodes
R13038 T16248 T16256 advmod Consistently,increased
R13039 T16249 T16248 prep with,Consistently
R13040 T16250 T16251 poss our,findings
R13041 T16251 T16249 pobj findings,with
R13042 T16252 T16256 punct ",",increased
R13043 T16253 T16254 amod MIP-1α,expression
R13044 T16254 T16256 nsubjpass expression,increased
R13045 T16255 T16256 auxpass was,increased
R13046 T16256 T16275 ccomp increased,induced
R13047 T16257 T16256 prep in,increased
R13048 T16258 T16259 amod glial,cells
R13049 T16259 T16257 pobj cells,in
R13050 T16260 T16259 cc and,cells
R13051 T16261 T16262 amod lymph,nodes
R13052 T16262 T16259 conj nodes,cells
R13053 T16263 T16262 prep of,nodes
R13054 T16264 T16265 compound AIDS,patients
R13055 T16265 T16263 pobj patients,of
R13056 T16266 T16265 punct (,patients
R13057 T16267 T16265 appos "57,58",patients
R13058 T16268 T16265 punct ),patients
R13059 T16269 T16275 punct ;,induced
R13060 T16270 T16275 advmod moreover,induced
R13061 T16271 T16275 punct ",",induced
R13062 T16272 T16273 compound MIP-1α,production
R13063 T16273 T16275 nsubjpass production,induced
R13064 T16274 T16275 auxpass was,induced
R13065 T16275 T16275 ROOT induced,induced
R13066 T16276 T16275 agent by,induced
R13067 T16277 T16278 compound HIV-1,infection
R13068 T16278 T16276 pobj infection,by
R13069 T16279 T16280 punct (,"59,60"
R13070 T16280 T16278 appos "59,60",infection
R13071 T16281 T16275 punct ),induced
R13072 T16282 T16275 cc and,induced
R13073 T16283 T16284 compound Tat,protein
R13074 T16284 T16275 conj protein,induced
R13075 T16285 T16286 punct (,"57,61,62"
R13076 T16286 T16284 appos "57,61,62",protein
R13077 T16287 T16284 punct ),protein
R13078 T16288 T16275 punct .,induced
R13079 T16289 T16291 det The,regulation
R13080 T16290 T16291 amod transcriptional,regulation
R13081 T16291 T16297 nsubjpass regulation,characterized
R13082 T16292 T16291 prep of,regulation
R13083 T16293 T16292 pobj MIP-1α,of
R13084 T16294 T16297 aux has,characterized
R13085 T16295 T16297 auxpass been,characterized
R13086 T16296 T16297 advmod poorly,characterized
R13087 T16297 T16297 ROOT characterized,characterized
R13088 T16298 T16297 punct .,characterized
R13089 T16299 T16300 amod Jaspar-based,analysis
R13090 T16300 T16304 nsubj analysis,predicted
R13091 T16301 T16300 punct (,analysis
R13092 T16302 T16300 appos http://jaspar.genereg.net/,analysis
R13093 T16303 T16300 punct ),analysis
R13094 T16304 T16304 ROOT predicted,predicted
R13095 T16305 T16308 nummod three,enhancers
R13096 T16306 T16308 amod putative,enhancers
R13097 T16307 T16308 compound NF-κB,enhancers
R13098 T16308 T16304 dobj enhancers,predicted
R13099 T16309 T16308 prep in,enhancers
R13100 T16310 T16313 det the,region
R13101 T16311 T16313 amod proximal,region
R13102 T16312 T16313 compound promoter,region
R13103 T16313 T16309 pobj region,in
R13104 T16314 T16313 prep of,region
R13105 T16315 T16317 det the,gene
R13106 T16316 T16317 compound MIP-1α,gene
R13107 T16317 T16314 pobj gene,of
R13108 T16318 T16308 punct :,enhancers
R13109 T16319 T16308 appos NF-κB1,enhancers
R13110 T16320 T16304 punct ",",predicted
R13111 T16321 T16324 meta −,−
R13112 T16322 T16323 nummod 1023,/
R13113 T16323 T16324 dep /,−
R13114 T16324 T16304 dep −,predicted
R13115 T16325 T16326 nummod 1014,nucleotides
R13116 T16326 T16324 dobj nucleotides,−
R13117 T16327 T16324 punct ;,−
R13118 T16328 T16324 conj NF-κB2,−
R13119 T16329 T16328 punct ",",NF-κB2
R13120 T16330 T16333 nummod −,−
R13121 T16331 T16333 nummod 661,−
R13122 T16332 T16333 compound /,−
R13123 T16333 T16328 appos −,NF-κB2
R13124 T16334 T16335 nummod 652,nucleotides
R13125 T16335 T16333 appos nucleotides,−
R13126 T16336 T16333 punct ;,−
R13127 T16337 T16333 conj NF-κB3,−
R13128 T16338 T16337 punct ",",NF-κB3
R13129 T16339 T16340 nummod +370,/
R13130 T16340 T16333 appos /,−
R13131 T16341 T16342 nummod +379,nucleotides
R13132 T16342 T16340 appos nucleotides,/
R13133 T16343 T16346 punct (,S3A
R13134 T16344 T16346 compound Supplementary,S3A
R13135 T16345 T16346 compound Figure,S3A
R13136 T16346 T16342 appos S3A,nucleotides
R13137 T16347 T16333 punct ),−
R13138 T16348 T16304 punct .,predicted
R13139 T16349 T16350 aux To,validate
R13140 T16350 T16362 advcl validate,stimulated
R13141 T16351 T16355 det the,sites
R13142 T16352 T16355 amod predicted,sites
R13143 T16353 T16355 amod NF-κB,sites
R13144 T16354 T16355 amod binding,sites
R13145 T16355 T16350 dobj sites,validate
R13146 T16356 T16355 prep of,sites
R13147 T16357 T16359 det the,promoter
R13148 T16358 T16359 amod MIP-1α,promoter
R13149 T16359 T16356 pobj promoter,of
R13150 T16360 T16362 punct ",",stimulated
R13151 T16361 T16362 nsubj we,stimulated
R13152 T16362 T16362 ROOT stimulated,stimulated
R13153 T16363 T16364 compound HeLa,cells
R13154 T16364 T16362 dobj cells,stimulated
R13155 T16365 T16362 prep with,stimulated
R13156 T16366 T16365 pobj TNF-α,with
R13157 T16367 T16366 punct ",",TNF-α
R13158 T16368 T16371 det a,inducer
R13159 T16369 T16371 amod well-known,inducer
R13160 T16370 T16371 compound NF-κB,inducer
R13161 T16371 T16366 appos inducer,TNF-α
R13162 T16372 T16362 punct ",",stimulated
R13163 T16373 T16362 cc and,stimulated
R13164 T16374 T16362 conj measured,stimulated
R13165 T16375 T16377 det the,levels
R13166 T16376 T16377 compound expression,levels
R13167 T16377 T16374 dobj levels,measured
R13168 T16378 T16377 prep of,levels
R13169 T16379 T16378 pobj MIP-1α,of
R13170 T16380 T16374 prep by,measured
R13171 T16381 T16382 amod real-time,PCR
R13172 T16382 T16380 pobj PCR,by
R13173 T16383 T16374 punct ",",measured
R13174 T16384 T16374 cc and,measured
R13175 T16385 T16387 det the,occupancy
R13176 T16386 T16387 amod p65,occupancy
R13177 T16387 T16374 conj occupancy,measured
R13178 T16388 T16387 prep of,occupancy
R13179 T16389 T16391 det the,sites
R13180 T16390 T16391 compound NF-κB,sites
R13181 T16391 T16388 pobj sites,of
R13182 T16392 T16387 prep by,occupancy
R13183 T16393 T16392 pobj ChIP,by
R13184 T16394 T16362 punct .,stimulated
R13185 T16395 T16396 nsubj TNF-α,activated
R13186 T16396 T16396 ROOT activated,activated
R13187 T16397 T16398 det the,expression
R13188 T16398 T16396 dobj expression,activated
R13189 T16399 T16398 prep of,expression
R13190 T16400 T16399 pobj MIP-1α,of
R13191 T16401 T16396 cc and,activated
R13192 T16402 T16396 conj induced,activated
R13193 T16403 T16405 det the,recruitment
R13194 T16404 T16405 nummod p65,recruitment
R13195 T16405 T16402 dobj recruitment,induced
R13196 T16406 T16402 prep to,induced
R13197 T16407 T16409 det the,site
R13198 T16408 T16409 amod NF-κB1,site
R13199 T16409 T16406 pobj site,to
R13200 T16410 T16409 prep of,site
R13201 T16411 T16410 pobj MIP-1α,of
R13202 T16412 T16402 prep without,induced
R13203 T16413 T16412 pcomp affecting,without
R13204 T16414 T16415 det the,occupancy
R13205 T16415 T16413 dobj occupancy,affecting
R13206 T16416 T16415 prep of,occupancy
R13207 T16417 T16419 det the,NF-κB2
R13208 T16418 T16419 amod putative,NF-κB2
R13209 T16419 T16416 pobj NF-κB2,of
R13210 T16420 T16419 cc and,NF-κB2
R13211 T16421 T16422 amod NF-κB3,sites
R13212 T16422 T16419 conj sites,NF-κB2
R13213 T16423 T16419 punct (,NF-κB2
R13214 T16424 T16426 compound Supplementary,S3B
R13215 T16425 T16426 compound Figure,S3B
R13216 T16426 T16419 appos S3B,NF-κB2
R13217 T16427 T16426 cc and,S3B
R13218 T16428 T16426 conj S3C,S3B
R13219 T16429 T16419 punct ),NF-κB2
R13220 T16430 T16396 punct .,activated
R13221 T16431 T16433 nsubj Tat,promoted
R13222 T16432 T16433 advmod also,promoted
R13223 T16433 T16433 ROOT promoted,promoted
R13224 T16434 T16435 det the,recruitment
R13225 T16435 T16433 dobj recruitment,promoted
R13226 T16436 T16435 prep of,recruitment
R13227 T16437 T16436 pobj p65,of
R13228 T16438 T16433 prep to,promoted
R13229 T16439 T16441 det the,site
R13230 T16440 T16441 amod NF-κB1,site
R13231 T16441 T16438 pobj site,to
R13232 T16442 T16441 prep of,site
R13233 T16443 T16442 pobj MIP-1α,of
R13234 T16444 T16433 punct ",",promoted
R13235 T16445 T16449 mark while,affect
R13236 T16446 T16449 nsubj it,affect
R13237 T16447 T16449 aux did,affect
R13238 T16448 T16449 neg not,affect
R13239 T16449 T16433 advcl affect,promoted
R13240 T16450 T16452 det the,NF-κB2
R13241 T16451 T16452 amod putative,NF-κB2
R13242 T16452 T16449 dobj NF-κB2,affect
R13243 T16453 T16452 cc and,NF-κB2
R13244 T16454 T16455 amod NF-κB3,sites
R13245 T16455 T16452 conj sites,NF-κB2
R13246 T16456 T16459 punct (,S3D
R13247 T16457 T16459 compound Supplementary,S3D
R13248 T16458 T16459 compound Figure,S3D
R13249 T16459 T16455 appos S3D,sites
R13250 T16460 T16455 punct ),sites
R13251 T16461 T16433 punct .,promoted
R13252 T16462 T16465 advmod Altogether,indicated
R13253 T16463 T16464 det these,results
R13254 T16464 T16465 nsubj results,indicated
R13255 T16465 T16465 ROOT indicated,indicated
R13256 T16466 T16470 mark that,was
R13257 T16467 T16469 det the,site
R13258 T16468 T16469 amod NF-κB1,site
R13259 T16469 T16470 nsubj site,was
R13260 T16470 T16465 ccomp was,indicated
R13261 T16471 T16475 det the,enhancer
R13262 T16472 T16475 amod only,enhancer
R13263 T16473 T16475 amod effective,enhancer
R13264 T16474 T16475 compound NF-κB,enhancer
R13265 T16475 T16470 attr enhancer,was
R13266 T16476 T16475 prep of,enhancer
R13267 T16477 T16479 det the,promoter
R13268 T16478 T16479 amod MIP-1α,promoter
R13269 T16479 T16476 pobj promoter,of
R13270 T16480 T16470 prep in,was
R13271 T16481 T16480 pobj response,in
R13272 T16482 T16481 prep to,response
R13273 T16483 T16482 pobj TNF-α,to
R13274 T16484 T16483 cc and,TNF-α
R13275 T16485 T16483 conj Tat,TNF-α
R13276 T16486 T16465 punct .,indicated
R13277 T16487 T16492 advmod Similarly,increased
R13278 T16488 T16487 prep to,Similarly
R13279 T16489 T16488 pobj MIP-1α,to
R13280 T16490 T16492 punct ",",increased
R13281 T16491 T16492 nsubj Tat,increased
R13282 T16492 T16492 ROOT increased,increased
R13283 T16493 T16494 det the,recruitment
R13284 T16494 T16492 dobj recruitment,increased
R13285 T16495 T16494 prep of,recruitment
R13286 T16496 T16495 pobj p65,of
R13287 T16497 T16492 prep to,increased
R13288 T16498 T16500 det the,enhancers
R13289 T16499 T16500 amod NF-κB,enhancers
R13290 T16500 T16497 pobj enhancers,to
R13291 T16501 T16500 prep of,enhancers
R13292 T16502 T16501 pobj CSF3,of
R13293 T16503 T16502 punct ",",CSF3
R13294 T16504 T16502 conj LTA,CSF3
R13295 T16505 T16504 punct ",",LTA
R13296 T16506 T16504 conj NFKBIA,LTA
R13297 T16507 T16506 cc and,NFKBIA
R13298 T16508 T16506 conj TLR2,NFKBIA
R13299 T16509 T16492 punct ",",increased
R13300 T16510 T16512 mark while,was
R13301 T16511 T16512 nsubj it,was
R13302 T16512 T16492 advcl was,increased
R13303 T16513 T16512 acomp ineffective,was
R13304 T16514 T16512 prep at,was
R13305 T16515 T16516 det the,promoters
R13306 T16516 T16514 pobj promoters,at
R13307 T16517 T16516 prep of,promoters
R13308 T16518 T16517 pobj GAPDH,of
R13309 T16519 T16518 cc and,GAPDH
R13310 T16520 T16518 conj ACTB,GAPDH
R13311 T16521 T16523 punct (,5H
R13312 T16522 T16523 compound Figure,5H
R13313 T16523 T16520 appos 5H,ACTB
R13314 T16524 T16523 punct ),5H
R13315 T16525 T16492 punct .,increased
R13316 T16526 T16530 prep By,bound
R13317 T16527 T16526 pobj ChIP,By
R13318 T16528 T16530 punct ",",bound
R13319 T16529 T16530 nsubj Tat,bound
R13320 T16530 T16530 ROOT bound,bound
R13321 T16531 T16530 prep to,bound
R13322 T16532 T16534 det the,promoters
R13323 T16533 T16534 amod NF-κB-responsive,promoters
R13324 T16534 T16531 pobj promoters,to
R13325 T16535 T16530 punct ",",bound
R13326 T16536 T16530 cc and,bound
R13327 T16537 T16538 neg not,to
R13328 T16538 T16530 conj to,bound
R13329 T16539 T16540 det the,GAPDH
R13330 T16540 T16538 pobj GAPDH,to
R13331 T16541 T16604 ccomp displaced,indicating
R13332 T16542 T16540 cc and,GAPDH
R13333 T16543 T16540 conj ACTB,GAPDH
R13334 T16544 T16540 conj promoters,GAPDH
R13335 T16545 T16530 punct ",",bound
R13336 T16546 T16530 prep with,bound
R13337 T16547 T16546 pobj loss,with
R13338 T16548 T16547 prep of,loss
R13339 T16549 T16550 amod binding,following
R13340 T16550 T16548 pobj following,of
R13341 T16551 T16553 nummod p65,interference
R13342 T16552 T16553 compound RNA,interference
R13343 T16553 T16550 dobj interference,following
R13344 T16554 T16556 punct (,5I
R13345 T16555 T16556 compound Figure,5I
R13346 T16556 T16553 appos 5I,interference
R13347 T16557 T16556 punct ),5I
R13348 T16558 T16530 punct ",",bound
R13349 T16559 T16530 advcl suggesting,bound
R13350 T16560 T16563 mark that,occurred
R13351 T16561 T16562 compound Tat,occupancy
R13352 T16562 T16563 nsubj occupancy,occurred
R13353 T16563 T16559 ccomp occurred,suggesting
R13354 T16564 T16563 prep via,occurred
R13355 T16565 T16566 nummod p65,interaction
R13356 T16566 T16564 pobj interaction,via
R13357 T16567 T16530 punct .,bound
R13358 T16568 T16574 prep As,chromatin-immunoprecipitated
R13359 T16569 T16570 amod additional,findings
R13360 T16570 T16568 pobj findings,As
R13361 T16571 T16574 punct ",",chromatin-immunoprecipitated
R13362 T16572 T16574 nsubjpass IκB-α,chromatin-immunoprecipitated
R13363 T16573 T16574 auxpass was,chromatin-immunoprecipitated
R13364 T16574 T16574 ROOT chromatin-immunoprecipitated,chromatin-immunoprecipitated
R13365 T16575 T16574 prep at,chromatin-immunoprecipitated
R13366 T16576 T16578 det the,enhancers
R13367 T16577 T16578 amod NF-κB,enhancers
R13368 T16578 T16575 pobj enhancers,at
R13369 T16579 T16578 prep in,enhancers
R13370 T16580 T16579 pobj absence,in
R13371 T16581 T16580 prep of,absence
R13372 T16582 T16581 pobj Tat,of
R13373 T16583 T16574 punct ",",chromatin-immunoprecipitated
R13374 T16584 T16574 cc and,chromatin-immunoprecipitated
R13375 T16585 T16588 nsubjpass it,removed
R13376 T16586 T16588 auxpass was,removed
R13377 T16587 T16588 advmod significantly,removed
R13378 T16588 T16574 conj removed,chromatin-immunoprecipitated
R13379 T16589 T16588 prep in,removed
R13380 T16590 T16589 pobj presence,in
R13381 T16591 T16590 prep of,presence
R13382 T16592 T16591 pobj Tat,of
R13383 T16593 T16588 punct ",",removed
R13384 T16594 T16588 cc or,removed
R13385 T16595 T16588 conj following,removed
R13386 T16596 T16598 compound IκB-α,interference
R13387 T16597 T16598 compound RNA,interference
R13388 T16598 T16595 dobj interference,following
R13389 T16599 T16600 punct (,Figure
R13390 T16600 T16598 appos Figure,interference
R13391 T16601 T16600 nummod 5J,Figure
R13392 T16602 T16600 punct ),Figure
R13393 T16603 T16595 punct ",",following
R13394 T16604 T16595 dep indicating,following
R13395 T16605 T16541 mark that,displaced
R13396 T16606 T16541 nsubj Tat,displaced
R13397 T16607 T16541 dobj IκB-α,displaced
R13398 T16608 T16541 prep from,displaced
R13399 T16609 T16608 pobj promoters,from
R13400 T16610 T16588 punct .,removed
R14637 T18292 T18296 prep In,sustains
R14638 T18293 T18295 amod HIV-1-infected,Tat
R14639 T18294 T18295 compound monocytes,Tat
R14640 T18295 T18292 pobj Tat,In
R14641 T18296 T18296 ROOT sustains,sustains
R14642 T18297 T18299 det the,activity
R14643 T18298 T18299 amod NF-κB,activity
R14644 T18299 T18296 dobj activity,sustains
R14645 T18300 T18296 cc and,sustains
R14646 T18301 T18296 conj promotes,sustains
R14647 T18302 T18304 det the,activation
R14648 T18303 T18304 amod transcriptional,activation
R14649 T18304 T18301 dobj activation,promotes
R14650 T18305 T18304 prep of,activation
R14651 T18306 T18305 pobj MIP-1α,of
R14652 T18307 T18301 prep by,promotes
R14653 T18308 T18307 pcomp interacting,by
R14654 T18309 T18308 prep with,interacting
R14655 T18310 T18309 pobj IκB-α,with
R14656 T18311 T18301 cc and,promotes
R14657 T18312 T18301 conj p65,promotes
R14658 T18313 T18315 nsubj We,analysed
R14659 T18314 T18315 advmod next,analysed
R14660 T18315 T18315 ROOT analysed,analysed
R14661 T18316 T18318 mark whether,affected
R14662 T18317 T18318 nsubj Tat,affected
R14663 T18318 T18315 ccomp affected,analysed
R14664 T18319 T18321 det the,activity
R14665 T18320 T18321 amod NF-κB,activity
R14666 T18321 T18318 dobj activity,affected
R14667 T18322 T18321 cc and,activity
R14668 T18323 T18324 det the,expression
R14669 T18324 T18321 conj expression,activity
R14670 T18325 T18324 prep of,expression
R14671 T18326 T18325 pobj MIP-1α,of
R14672 T18327 T18318 prep in,affected
R14673 T18328 T18329 det the,course
R14674 T18329 T18327 pobj course,in
R14675 T18330 T18329 prep of,course
R14676 T18331 T18332 compound HIV-1,infection
R14677 T18332 T18330 pobj infection,of
R14678 T18333 T18315 punct .,analysed
R14679 T18334 T18335 aux To,detect
R14680 T18335 T18341 advcl detect,produced
R14681 T18336 T18338 det the,protein
R14682 T18337 T18338 compound Tat,protein
R14683 T18338 T18335 dobj protein,detect
R14684 T18339 T18341 punct ",",produced
R14685 T18340 T18341 nsubj we,produced
R14686 T18341 T18341 ROOT produced,produced
R14687 T18342 T18344 compound HXB2,NL4-3
R14688 T18343 T18344 compound Env-pseudotyped,NL4-3
R14689 T18344 T18341 dobj NL4-3,produced
R14690 T18345 T18341 punct .,produced
R14691 T18346 T18346 ROOT FLAG-Tat,FLAG-Tat
R14692 T18347 T18346 punct .,FLAG-Tat
R14693 T18348 T18349 compound R,−
R14694 T18349 T18349 ROOT −,−
R14734 T18389 T18379 conj analysed,left
R14735 T18390 T18389 prep for,analysed
R14736 T18391 T18392 det the,kinetic
R14737 T18392 T18390 pobj kinetic,for
R14738 T18393 T18392 prep of,kinetic
R14739 T18394 T18395 amod NF-κB,activation
R14740 T18395 T18393 pobj activation,of
R14741 T18396 T18392 prep following,kinetic
R14742 T18397 T18398 amod viral,infection
R14743 T18398 T18396 pobj infection,following
R14744 T18399 T18379 punct .,left
R14745 T18400 T18401 det The,expression
R14746 T18401 T18407 nsubjpass expression,detected
R14747 T18402 T18401 prep of,expression
R14748 T18403 T18402 pobj Tat,of
R14749 T18404 T18401 cc and,expression
R14750 T18405 T18407 nsubjpass p24,detected
R14751 T18406 T18407 auxpass was,detected
R14752 T18407 T18407 ROOT detected,detected
R14753 T18408 T18407 prep at,detected
R14754 T18409 T18408 pobj 3,at
R14755 T18410 T18412 punct -,12-h
R14756 T18411 T18412 aux to,12-h
R14757 T18412 T18409 dep 12-h,3
R14758 T18413 T18412 prep post-infection,12-h
R14759 T18414 T18407 punct ",",detected
R14760 T18415 T18419 mark while,detected
R14761 T18416 T18419 nsubjpass it,detected
R14762 T18417 T18419 auxpass was,detected
R14763 T18418 T18419 advmod barely,detected
R14764 T18419 T18407 advcl detected,detected
R14765 T18420 T18419 prep in,detected
R14766 T18421 T18420 pobj siRNA,in
R14767 T18422 T18423 compound Tat-transfected,cells
R14768 T18423 T18407 oprd cells,detected
R14769 T18424 T18426 punct (,6A
R14770 T18425 T18426 compound Figure,6A
R14771 T18426 T18423 appos 6A,cells
R14772 T18427 T18423 punct ),cells
R14773 T18428 T18407 punct .,detected
R14774 T18429 T18431 det The,activity
R14793 T18448 T18450 punct (,siRNA
R14794 T18449 T18450 det no,siRNA
R14795 T18450 T18447 appos siRNA,Tat-positive
R14796 T18451 T18450 cc and,siRNA
R14797 T18452 T18453 compound siRNA,control
R14798 T18453 T18450 conj control,siRNA
R14799 T18454 T18450 punct ),siRNA
R14800 T18455 T18447 cc and,Tat-positive
R14801 T18456 T18457 amod Tat-negative,cells
R14802 T18457 T18445 pobj cells,in
R14803 T18458 T18460 punct (,Tat
R14804 T18459 T18460 compound siRNA,Tat
R14805 T18460 T18441 npadvmod Tat,induced
R14806 T18461 T18460 punct ),Tat
R14807 T18462 T18441 punct ",",induced
R14808 T18463 T18441 cc and,induced
R14809 T18464 T18441 conj increased,induced
R14810 T18465 T18464 prep at,increased
R14811 T18466 T18467 nummod 12,h
R14812 T18467 T18465 pobj h,at
R14813 T18468 T18469 advmod only,in
R14814 T18469 T18467 prep in,h
R14815 T18470 T18471 amod Tat-positive,cells
R14816 T18471 T18469 pobj cells,in
R14817 T18472 T18474 punct (,6B
R14818 T18473 T18474 compound Figure,6B
R14819 T18474 T18467 appos 6B,h
R14820 T18475 T18474 punct ),6B
R14821 T18476 T18441 punct .,induced
R14822 T18477 T18481 nsubjpass Degradation,observed
R14823 T18478 T18477 prep of,Degradation
R14824 T18479 T18478 pobj IκB-α,of
R14825 T18480 T18481 auxpass was,observed
R14826 T18481 T18481 ROOT observed,observed
R14827 T18482 T18481 prep at,observed
R14828 T18483 T18484 amod 3-h,post-infection
R14829 T18484 T18482 pobj post-infection,at
R14830 T18485 T18481 punct ",",observed
R14831 T18486 T18481 cc and,observed
R14832 T18487 T18488 auxpass was,followed
R14833 T18488 T18481 conj followed,observed
R14834 T18489 T18488 agent by,followed
R14835 T18490 T18492 nmod de,synthesis
R14836 T18491 T18492 amod novo,synthesis
R14837 T18492 T18489 pobj synthesis,by
R14838 T18493 T18492 prep of,synthesis
R14839 T18494 T18493 pobj IκB-α,of
R14840 T18495 T18492 prep at,synthesis
R14841 T18496 T18497 nummod 12,h
R14842 T18497 T18495 pobj h,at
R14843 T18498 T18492 advmod independently,synthesis
R14844 T18499 T18498 prep of,independently
R14845 T18500 T18502 det the,presence
R14846 T18501 T18502 compound Tat,presence
R14847 T18502 T18499 pobj presence,of
R14848 T18503 T18505 punct (,6C
R14849 T18504 T18505 compound Figure,6C
R14850 T18505 T18502 appos 6C,presence
R14851 T18506 T18505 punct ),6C
R14852 T18507 T18481 punct .,observed
R14853 T18508 T18514 advmod Consistently,induced
R14854 T18509 T18514 punct ",",induced
R14855 T18510 T18512 det the,activity
R14856 T18511 T18512 compound IKK,activity
R14857 T18512 T18514 nsubjpass activity,induced
R14858 T18513 T18514 auxpass was,induced
R14859 T18514 T18514 ROOT induced,induced
R14860 T18515 T18514 prep at,induced
R14861 T18516 T18517 amod 3-h,post-infection
R14862 T18517 T18515 pobj post-infection,at
R14863 T18518 T18514 cc and,induced
R14864 T18519 T18514 conj turned,induced
R14865 T18520 T18519 prt off,turned
R14866 T18521 T18519 prep at,turned
R14867 T18522 T18523 nummod 12,h
R14868 T18523 T18521 pobj h,at
R14869 T18524 T18523 advmod independently,h
R14870 T18525 T18524 prep of,independently
R14871 T18526 T18528 det the,presence
R14872 T18527 T18528 compound Tat,presence
R14873 T18528 T18525 pobj presence,of
R14874 T18529 T18530 punct (,Figure
R14875 T18530 T18528 appos Figure,presence
R14876 T18531 T18530 nummod 6D,Figure
R14877 T18532 T18530 punct ),Figure
R14878 T18533 T18514 punct .,induced
R14879 T18534 T18535 det These,results
R14880 T18535 T18536 nsubj results,agreed
R14881 T18536 T18536 ROOT agreed,agreed
R14882 T18537 T18536 prep with,agreed
R14883 T18538 T18539 det the,kinetic
R14884 T18539 T18537 pobj kinetic,with
R14885 T18540 T18539 prep of,kinetic
R14886 T18541 T18542 amod NF-κB,activation
R14887 T18542 T18540 pobj activation,of
R14888 T18543 T18542 prep in,activation
R14889 T18544 T18546 amod single-round,infection
R14890 T18545 T18546 amod HIV-1,infection
R14891 T18546 T18543 pobj infection,in
R14892 T18547 T18546 prep of,infection
R14893 T18548 T18549 compound Jurkat,cells
R14894 T18549 T18547 pobj cells,of
R14895 T18550 T18551 punct (,Figure
R14896 T18551 T18546 appos Figure,infection
R14897 T18552 T18551 nummod 1,Figure
R14898 T18553 T18551 punct ),Figure
R14899 T18554 T18551 punct ",",Figure
R14900 T18555 T18536 cc and,agreed
R14901 T18556 T18557 advmod further,supported
R14902 T18557 T18536 conj supported,agreed
R14903 T18558 T18559 det the,requirement
R14904 T18559 T18557 dobj requirement,supported
R14905 T18560 T18559 prep of,requirement
R14906 T18561 T18562 amod viral,expression
R14907 T18562 T18560 pobj expression,of
R14908 T18563 T18564 aux to,counteract
R14909 T18564 T18559 acl counteract,requirement
R14910 T18565 T18567 det the,turn
R14911 T18566 T18567 compound post-activation,turn
R14912 T18567 T18564 dobj turn,counteract
R14913 T18568 T18564 advmod off,counteract
R14914 T18569 T18568 prep of,off
R14915 T18570 T18569 pobj NF-κB,of
R14916 T18571 T18536 punct .,agreed
R14917 T18572 T18581 prep In,coimmunoprecipitated
R14918 T18573 T18575 amod HIV-1-infected,cells
R14919 T18574 T18575 compound U937,cells
R14920 T18575 T18572 pobj cells,In
R14921 T18576 T18581 punct ",",coimmunoprecipitated
R14922 T18577 T18579 det the,Tat
R14923 T18578 T18579 compound endogenous,Tat
R14924 T18579 T18581 nsubjpass Tat,coimmunoprecipitated
R14925 T18580 T18581 auxpass was,coimmunoprecipitated
R14926 T18581 T18581 ROOT coimmunoprecipitated,coimmunoprecipitated
R14927 T18582 T18581 prep with,coimmunoprecipitated
R14928 T18583 T18582 pobj IκB-α,with
R14929 T18584 T18583 cc and,IκB-α
R14930 T18585 T18583 conj p65,IκB-α
R14931 T18586 T18587 punct (,Figure
R14969 T18624 T18622 conj p65,Tat
R14970 T18625 T18627 auxpass were,recruited
R14971 T18626 T18627 dep both,recruited
R14972 T18627 T18627 ROOT recruited,recruited
R14973 T18628 T18627 prep to,recruited
R14974 T18629 T18631 det the,enhancer
R14975 T18630 T18631 amod NF-κB,enhancer
R14976 T18631 T18628 pobj enhancer,to
R14977 T18632 T18631 prep of,enhancer
R14978 T18633 T18632 pobj MIP-1α,of
R14979 T18634 T18627 punct ",",recruited
R14980 T18635 T18640 mark while,abolished
R14981 T18636 T18638 det the,occupancy
R14982 T18637 T18638 nummod p65,occupancy
R14983 T18638 T18640 nsubjpass occupancy,abolished
R14984 T18639 T18640 auxpass was,abolished
R14985 T18640 T18627 advcl abolished,recruited
R14986 T18641 T18640 agent by,abolished
R14987 T18642 T18643 compound siRNA,Tat
R14988 T18643 T18641 pobj Tat,by
R14989 T18644 T18646 punct (,6G
R14990 T18645 T18646 compound Figure,6G
R14991 T18646 T18643 appos 6G,Tat
R14992 T18647 T18646 cc and,6G
R14993 T18648 T18646 conj H,6G
R14994 T18649 T18646 punct ),6G
R14995 T18650 T18627 punct .,recruited
R14996 T18651 T18654 advmod Altogether,indicated
R14997 T18652 T18653 det these,results
R14998 T18653 T18654 nsubj results,indicated
R14999 T18654 T18654 ROOT indicated,indicated
R15000 T18655 T18662 mark that,associated
R15001 T18656 T18662 prep in,associated
R15002 T18657 T18661 amod single,Tat
R15003 T18658 T18661 compound round,Tat
R15004 T18659 T18661 compound HIV-1,Tat
R15005 T18660 T18661 compound infection,Tat
R15006 T18661 T18656 pobj Tat,in
R15007 T18662 T18654 ccomp associated,indicated
R15008 T18663 T18662 prep with,associated
R15009 T18664 T18663 pobj IκB-α,with
R16946 T21255 T21287 prep Based,investigated
R16947 T21256 T21255 prep on,Based
R16948 T21257 T21258 det the,evidence
R16949 T21258 T21256 pobj evidence,on
R16950 T21259 T21261 mark that,enhanced
R16951 T21260 T21261 nsubj Tat,enhanced
R16952 T21261 T21258 acl enhanced,evidence
R16953 T21262 T21264 det the,activity
R16954 T21263 T21264 amod transcriptional,activity
R16955 T21264 T21261 dobj activity,enhanced
R16956 T21265 T21264 prep of,activity
R16957 T21266 T21268 det the,subunit
R16958 T21267 T21268 nummod p65,subunit
R16959 T21268 T21265 pobj subunit,of
R16960 T21269 T21268 prep of,subunit
R16961 T21270 T21269 pobj NF-κB,of
R16962 T21271 T21270 punct (,NF-κB
R16963 T21272 T21270 appos "49,63,64",NF-κB
R16964 T21273 T21270 punct ),NF-κB
R16965 T21274 T21261 punct ",",enhanced
R16966 T21275 T21261 cc and,enhanced
R16967 T21276 T21277 advmod physically,interacted
R16968 T21277 T21261 conj interacted,enhanced
R16969 T21278 T21277 prep with,interacted
R16970 T21279 T21281 det the,repressor
R16971 T21280 T21281 amod IκB-α,repressor
R16972 T21281 T21278 pobj repressor,with
R16973 T21282 T21281 punct (,repressor
R16974 T21283 T21281 appos "50,51",repressor
R16975 T21284 T21281 punct ),repressor
R16976 T21285 T21287 punct ",",investigated
R16977 T21286 T21287 nsubj we,investigated
R16978 T21287 T21287 ROOT investigated,investigated
R16979 T21288 T21289 det the,possibility
R16980 T21289 T21287 dobj possibility,investigated
R16981 T21290 T21293 mark that,activate
R16982 T21291 T21293 nsubj Tat,activate
R16983 T21292 T21293 aux could,activate
R16984 T21293 T21289 acl activate,possibility
R16985 T21294 T21293 dobj NF-κB,activate
R16986 T21295 T21293 prep via,activate
R16987 T21296 T21297 amod direct,interaction
R17006 T21315 T21316 compound HIV-1,infection
R17007 T21316 T21312 pobj infection,in
R17008 T21317 T21311 advcl using,monitored
R17009 T21318 T21319 compound RNA,interference
R17010 T21319 T21317 dobj interference,using
R17011 T21320 T21321 aux to,silence
R17012 T21321 T21317 xcomp silence,using
R17013 T21322 T21324 det the,expression
R17014 T21323 T21324 compound Tat,expression
R17015 T21324 T21321 dobj expression,silence
R17016 T21325 T21311 punct .,monitored
R17017 T21326 T21331 prep By,avoided
R17018 T21327 T21328 det this,approach
R17019 T21328 T21326 pobj approach,By
R17020 T21329 T21331 punct ",",avoided
R17021 T21330 T21331 nsubj we,avoided
R17022 T21331 T21331 ROOT avoided,avoided
R17023 T21332 T21333 det the,perpetuation
R17024 T21333 T21331 dobj perpetuation,avoided
R17025 T21334 T21333 prep of,perpetuation
R17026 T21335 T21336 amod NF-κB,activation
R17027 T21336 T21334 pobj activation,of
R17028 T21337 T21333 acl signaling,perpetuation
R17029 T21338 T21337 prep due,signaling
R17030 T21339 T21338 pcomp to,due
R17031 T21340 T21341 amod subsequent,rounds
R17032 T21341 T21338 pobj rounds,due
R17033 T21342 T21341 prep of,rounds
R17034 T21343 T21344 amod viral,entry
R17035 T21344 T21342 pobj entry,of
R17036 T21345 T21341 prep in,rounds
R17037 T21346 T21347 compound cell,culture
R17038 T21347 T21348 compound culture,propagation
R17039 T21348 T21345 pobj propagation,in
R17040 T21349 T21348 punct (,propagation
R17041 T21350 T21348 appos "30,31",propagation
R17042 T21351 T21348 punct ),propagation
R17043 T21352 T21331 punct .,avoided
R17044 T21353 T21361 prep Upon,occurred
R17045 T21354 T21355 compound HIV-1,infection
R17046 T21355 T21353 pobj infection,Upon
R17047 T21356 T21361 punct ",",occurred
R17048 T21357 T21360 det the,activation
R17049 T21358 T21360 amod early,activation
R17050 T21359 T21360 compound NF-κB,activation
R17051 T21360 T21361 nsubj activation,occurred
R17052 T21361 T21361 ROOT occurred,occurred
R17053 T21362 T21361 advmod concomitantly,occurred
R17054 T21363 T21361 prep with,occurred
R17055 T21364 T21365 compound IKK,activation
R17056 T21365 T21363 pobj activation,with
R17057 T21366 T21365 cc and,activation
R17058 T21367 T21368 amod IκB-α,degradation
R17059 T21368 T21365 conj degradation,activation
R17060 T21369 T21361 prep in,occurred
R17061 T21370 T21371 det the,absence
R17062 T21371 T21369 pobj absence,in
R17063 T21372 T21371 prep of,absence
R17064 T21373 T21372 pobj Tat,of
R17065 T21374 T21361 punct .,occurred
R17066 T21375 T21378 advmod Soon,shut
R17067 T21376 T21378 mark after,shut
R17068 T21377 T21378 det the,shut
R17069 T21378 T21393 advcl shut,kept
R17070 T21379 T21378 prt off,shut
R17071 T21380 T21379 prep of,off
R17072 T21381 T21382 compound IKK,activity
R17073 T21382 T21380 pobj activity,of
R17074 T21383 T21382 cc and,activity
R17075 T21384 T21385 amod new,synthesis
R17076 T21385 T21382 conj synthesis,activity
R17077 T21386 T21385 prep of,synthesis
R17078 T21387 T21386 pobj IκB-α,of
R17079 T21388 T21393 punct ",",kept
R17080 T21389 T21391 det the,activity
R17081 T21390 T21391 compound NF-κB,activity
R17082 T21391 T21393 nsubjpass activity,kept
R17083 T21392 T21393 auxpass was,kept
R17084 T21393 T21393 ROOT kept,kept
R17085 T21394 T21393 xcomp elevated,kept
R17086 T21395 T21394 prep in,elevated
R17087 T21396 T21397 det the,presence
R17088 T21397 T21395 pobj presence,in
R17089 T21398 T21397 prep of,presence
R17090 T21399 T21398 pobj Tat,of
R17091 T21400 T21393 punct ",",kept
R17092 T21401 T21403 mark while,was
R17093 T21402 T21403 nsubj it,was
R17094 T21403 T21405 auxpass was,regulated
R17095 T21404 T21405 advmod down,regulated
R17096 T21405 T21393 advcl regulated,kept
R17097 T21406 T21405 prep upon,regulated
R17098 T21407 T21406 pcomp silencing,upon
R17099 T21408 T21407 prep of,silencing
R17100 T21409 T21411 det the,gene
R17101 T21410 T21411 compound Tat,gene
R17102 T21411 T21408 pobj gene,of
R17103 T21412 T21393 punct .,kept
R17104 T21413 T21414 det These,findings
R17105 T21414 T21415 nsubj findings,indicate
R17106 T21415 T21415 ROOT indicate,indicate
R17107 T21416 T21424 mark that,enhanced
R17108 T21417 T21424 prep in,enhanced
R17109 T21418 T21421 amod single,infection
R17110 T21419 T21421 compound round,infection
R17111 T21420 T21421 compound HIV-1,infection
R17112 T21421 T21417 pobj infection,in
R17113 T21422 T21424 punct ",",enhanced
R17114 T21423 T21424 nsubj Tat,enhanced
R17115 T21424 T21415 ccomp enhanced,indicate
R17116 T21425 T21427 det the,activity
R17117 T21426 T21427 amod NF-κB,activity
R17118 T21427 T21424 dobj activity,enhanced
R17119 T21428 T21424 prep without,enhanced
R17120 T21429 T21428 pcomp affecting,without
R17121 T21430 T21432 det the,activity
R17122 T21431 T21432 compound IKK,activity
R17123 T21432 T21429 dobj activity,affecting
R17124 T21433 T21432 cc and,activity
R17125 T21434 T21435 det the,half-life
R17126 T21435 T21432 conj half-life,activity
R17127 T21436 T21435 prep of,half-life
R17128 T21437 T21436 pobj IκB-α,of
R17129 T21438 T21415 punct .,indicate
R17130 T21439 T21440 amod Similar,kinetic
R17131 T21440 T21444 nsubj kinetic,occurred
R17132 T21441 T21440 prep of,kinetic
R17133 T21442 T21443 amod NF-κB,activation
R17134 T21443 T21441 pobj activation,of
R17135 T21444 T21444 ROOT occurred,occurred
R17136 T21445 T21444 prep upon,occurred
R17137 T21446 T21445 pobj short-pulse,upon
R17138 T21447 T21446 prep of,short-pulse
R17139 T21448 T21447 pobj PMA,of
R17140 T21449 T21446 prep in,short-pulse
R17141 T21450 T21451 compound Tat-transfected,HeLa
R17142 T21451 T21452 compound HeLa,cells
R17143 T21452 T21449 pobj cells,in
R17144 T21453 T21446 punct ",",short-pulse
R17145 T21454 T21456 advmod where,inhibited
R17146 T21455 T21456 nsubj Tat,inhibited
R17147 T21456 T21444 advcl inhibited,occurred
R17148 T21457 T21459 det the,turn
R17149 T21458 T21459 amod post-activation,turn
R17150 T21459 T21456 dobj turn,inhibited
R17151 T21460 T21459 prt off,turn
R17152 T21461 T21459 prep of,turn
R17153 T21462 T21461 pobj NF-κB,of
R17154 T21463 T21459 prep in,turn
R17155 T21464 T21463 pobj presence,in
R17156 T21465 T21464 prep of,presence
R17157 T21466 T21467 advmod newly,synthesized
R17158 T21467 T21468 amod synthesized,IκB-α
R17159 T21468 T21465 pobj IκB-α,of
R17160 T21469 T21444 punct .,occurred
R17161 T21470 T21472 det The,activation
R17162 T21471 T21472 amod Tat-dependent,activation
R17163 T21472 T21472 ROOT activation,activation
R17164 T21473 T21472 prep of,activation
R17165 T21474 T21473 pobj NF-κB,of
R17166 T21475 T21472 acl correlated,activation
R17167 T21476 T21475 prep with,correlated
R17168 T21477 T21478 det the,association
R17169 T21478 T21476 pobj association,with
R17170 T21479 T21478 prep of,association
R17171 T21480 T21482 det the,protein
R17172 T21481 T21482 amod viral,protein
R17173 T21482 T21479 pobj protein,of
R17174 T21483 T21478 prep with,association
R17175 T21484 T21483 pobj IκB-α,with
R17176 T21485 T21484 punct ",",IκB-α
R17177 T21486 T21487 nsubj which,interfered
R17178 T21487 T21484 relcl interfered,IκB-α
R17179 T21488 T21487 prep with,interfered
R17180 T21489 T21490 det the,generation
R17181 T21490 T21488 pobj generation,with
R17182 T21491 T21490 prep of,generation
R17183 T21492 T21496 det the,complex
R17184 T21493 T21496 nmod IκB-α,complex
R17185 T21494 T21496 nmod /,complex
R17186 T21495 T21494 nummod p65,/
R17187 T21496 T21491 pobj complex,of
R17188 T21497 T21472 punct .,activation
R17189 T21498 T21499 det This,evidence
R17190 T21499 T21500 nsubj evidence,demonstrated
R17191 T21500 T21500 ROOT demonstrated,demonstrated
R17192 T21501 T21503 mark that,competed
R17193 T21502 T21503 nsubj Tat,competed
R17194 T21503 T21500 ccomp competed,demonstrated
R17195 T21504 T21503 prep for,competed
R17196 T21505 T21506 det the,binding
R17197 T21506 T21504 pobj binding,for
R17198 T21507 T21506 prep of,binding
R17199 T21508 T21507 pobj IκB-α,of
R17200 T21509 T21510 aux to,p65
R17201 T21510 T21503 advcl p65,competed
R17202 T21511 T21503 cc and,competed
R17203 T21512 T21503 conj prevented,competed
R17204 T21513 T21515 det the,repression
R17205 T21514 T21515 amod IκB-α,repression
R17206 T21515 T21512 dobj repression,prevented
R17207 T21516 T21515 prep of,repression
R17208 T21517 T21516 pobj p65,of
R17209 T21518 T21500 punct .,demonstrated
R17210 T21519 T21527 prep As,associated
R17211 T21520 T21521 amod additional,mechanism
R17212 T21521 T21519 pobj mechanism,As
R17213 T21522 T21521 prep of,mechanism
R17214 T21523 T21524 amod NF-κB,activation
R17215 T21524 T21522 pobj activation,of
R17216 T21525 T21527 punct ",",associated
R17217 T21526 T21527 npadvmod Tat,associated
R17218 T21527 T21527 ROOT associated,associated
R17219 T21528 T21527 prep with,associated
R17220 T21529 T21528 pobj p65,with
R17221 T21530 T21527 cc and,associated
R17222 T21531 T21527 conj increased,associated
R17223 T21532 T21535 det the,affinity
R17224 T21533 T21535 nummod p65,affinity
R17225 T21534 T21535 amod binding,affinity
R17226 T21535 T21531 dobj affinity,increased
R17227 T21536 T21531 prep to,increased
R17228 T21537 T21539 det the,enhancer
R17229 T21538 T21539 amod NF-κB,enhancer
R17230 T21539 T21536 pobj enhancer,to
R17231 T21540 T21544 punct ;,obtained
R17232 T21541 T21542 det this,evidence
R17233 T21542 T21544 nsubjpass evidence,obtained
R17234 T21543 T21544 auxpass was,obtained
R17235 T21544 T21527 conj obtained,associated
R17236 T21545 T21544 prep with,obtained
R17237 T21546 T21547 amod recombinant,proteins
R17238 T21547 T21545 pobj proteins,with
R17239 T21548 T21544 advcl indicating,obtained
R17240 T21549 T21557 mark that,was
R17241 T21550 T21552 det the,binding
R17242 T21551 T21552 amod stronger,binding
R17243 T21552 T21557 nsubj binding,was
R17244 T21553 T21552 prep of,binding
R17245 T21554 T21553 pobj p65,of
R17246 T21555 T21552 prep to,binding
R17247 T21556 T21555 pobj DNA,to
R17248 T21557 T21548 ccomp was,indicating
R17249 T21558 T21559 det a,consequence
R17250 T21559 T21557 attr consequence,was
R17251 T21560 T21559 prep of,consequence
R17252 T21561 T21562 amod direct,association
R17253 T21562 T21560 pobj association,of
R17254 T21563 T21562 prep with,association
R17255 T21564 T21563 pobj Tat,with
R17256 T21565 T21562 punct ",",association
R17257 T21566 T21568 nsubj which,caused
R17258 T21567 T21568 advmod likely,caused
R17259 T21568 T21559 relcl caused,consequence
R17260 T21569 T21571 det a,change
R17261 T21570 T21571 amod conformational,change
R17262 T21571 T21568 dobj change,caused
R17263 T21572 T21571 prep of,change
R17264 T21573 T21572 pobj p65,of
R17265 T21574 T21544 punct .,obtained
R17266 T21575 T21577 nsubj We,demonstrated
R17267 T21576 T21577 advmod also,demonstrated
R17268 T21577 T21577 ROOT demonstrated,demonstrated
R17269 T21578 T21588 mark that,involved
R17270 T21579 T21582 det the,sequence
R17271 T21580 T21582 compound Tat,sequence
R17272 T21581 T21582 compound cysteine-rich,sequence
R17273 T21582 T21588 nsubjpass sequence,involved
R17274 T21583 T21582 punct (,sequence
R17275 T21584 T21585 nummod C22,",25,27"
R17276 T21585 T21582 appos ",25,27",sequence
R17277 T21586 T21582 punct ),sequence
R17278 T21587 T21588 auxpass was,involved
R17279 T21588 T21577 ccomp involved,demonstrated
R17280 T21589 T21588 prep in,involved
R17281 T21590 T21591 det the,binding
R17282 T21591 T21589 pobj binding,in
R17283 T21592 T21591 prep to,binding
R17284 T21593 T21594 det the,RHD
R17285 T21594 T21592 pobj RHD,to
R17286 T21595 T21594 prep of,RHD
R17287 T21596 T21599 nummod p65,activation
R17288 T21597 T21596 cc and,p65
R17289 T21598 T21599 compound NF-κB,activation
R17290 T21599 T21595 pobj activation,of
R17291 T21600 T21577 punct .,demonstrated
R17292 T21601 T21612 advmod Differently,required
R17293 T21602 T21612 punct ",",required
R17294 T21603 T21606 det the,sequence
R17295 T21604 T21606 nmod Tat,sequence
R17296 T21605 T21606 amod arginine-rich,sequence
R17297 T21606 T21612 nsubjpass sequence,required
R17298 T21607 T21606 punct (,sequence
R17299 T21608 T21609 nummod R49,",52,53,55,56,57"
R17300 T21609 T21606 appos ",52,53,55,56,57",sequence
R17301 T21610 T21606 punct ),sequence
R17302 T21611 T21612 auxpass was,required
R17303 T21612 T21612 ROOT required,required
R17304 T21613 T21612 prep for,required
R17305 T21614 T21615 det the,binding
R17306 T21615 T21616 nsubj binding,to
R17307 T21616 T21612 prep to,required
R17308 T21617 T21619 det the,ankyrin
R17309 T21618 T21619 amod sixth,ankyrin
R17310 T21619 T21616 pobj ankyrin,to
R17311 T21620 T21619 prep of,ankyrin
R17312 T21621 T21620 pobj IκB-α,of
R17313 T21622 T21621 punct (,IκB-α
R17314 T21623 T21621 parataxis "50,51",IκB-α
R17315 T21624 T21621 punct ),IκB-α
R17316 T21625 T21612 punct ",",required
R17317 T21626 T21612 cc and,required
R17318 T21627 T21612 conj for,required
R17319 T21628 T21627 pcomp releasing,for
R17320 T21629 T21628 dobj p65,releasing
R17321 T21630 T21628 prep from,releasing
R17322 T21631 T21633 det the,inhibition
R17323 T21632 T21633 amod IκB-α,inhibition
R17324 T21633 T21630 pobj inhibition,from
R17325 T21634 T21612 punct .,required
R17326 T21635 T21638 advmod Altogether,demonstrated
R17327 T21636 T21637 det these,results
R17328 T21637 T21638 nsubj results,demonstrated
R17329 T21638 T21638 ROOT demonstrated,demonstrated
R17330 T21639 T21641 mark that,abolished
R17331 T21640 T21641 nsubj Tat,abolished
R17332 T21641 T21638 ccomp abolished,demonstrated
R17333 T21642 T21645 det the,regulation
R17334 T21643 T21645 amod negative,regulation
R17335 T21644 T21645 compound feedback,regulation
R17336 T21645 T21641 dobj regulation,abolished
R17337 T21646 T21645 prep of,regulation
R17338 T21647 T21646 pobj NF-κB,of
R17339 T21648 T21641 prep by,abolished
R17340 T21649 T21648 pcomp hijacking,by
R17341 T21650 T21652 det the,repressor
R17342 T21651 T21652 amod IκB-α,repressor
R17343 T21652 T21649 dobj repressor,hijacking
R17344 T21653 T21649 punct ",",hijacking
R17345 T21654 T21648 pcomp shielding,by
R17346 T21655 T21654 dobj p65,shielding
R17347 T21656 T21654 prep from,shielding
R17348 T21657 T21659 det the,embrace
R17349 T21658 T21659 amod IκB-α,embrace
R17350 T21659 T21656 pobj embrace,from
R17351 T21660 T21654 punct ",",shielding
R17352 T21661 T21654 cc and,shielding
R17353 T21662 T21654 conj enforcing,shielding
R17354 T21663 T21665 det the,binding
R17355 T21664 T21665 advmod p65,binding
R17356 T21665 T21662 dobj binding,enforcing
R17357 T21666 T21665 prep to,binding
R17358 T21667 T21666 pobj DNA,to
R17359 T21668 T21638 punct .,demonstrated
R17360 T21669 T21670 amod Further,evidence
R17361 T21670 T21676 nsubj evidence,showed
R17362 T21671 T21670 prep of,evidence
R17363 T21672 T21671 pobj Tat,of
R17364 T21673 T21670 conj activation,evidence
R17365 T21674 T21673 prep of,activation
R17366 T21675 T21674 pobj NF-κB,of
R17367 T21676 T21676 ROOT showed,showed
R17368 T21677 T21679 det that,Tat
R17369 T21678 T21679 compound wild-type,Tat
R17370 T21679 T21676 ccomp Tat,showed
R17371 T21680 T21679 punct ",",Tat
R17372 T21681 T21679 cc and,Tat
R17373 T21682 T21685 neg not,mutants
R17374 T21683 T21685 det the,mutants
R17375 T21684 T21685 compound Tat,mutants
R17376 T21685 T21679 conj mutants,Tat
R17377 T21686 T21685 acl lacking,mutants
R17378 T21687 T21688 det the,arginine
R17379 T21688 T21686 dobj arginine,lacking
R17380 T21689 T21688 punct -,arginine
R17381 T21690 T21688 cc or,arginine
R17382 T21691 T21692 amod cysteine-rich,domains
R17383 T21692 T21688 conj domains,arginine
R17384 T21693 T21692 punct ",",domains
R17385 T21694 T21679 conj up-regulated,Tat
R17386 T21695 T21694 prep in,up-regulated
R17387 T21696 T21695 pobj vivo,in
R17388 T21697 T21698 det the,expression
R17389 T21698 T21679 appos expression,Tat
R17390 T21699 T21698 prep of,expression
R17391 T21700 T21701 det a,number
R17392 T21701 T21699 pobj number,of
R17393 T21702 T21701 prep of,number
R17394 T21703 T21704 amod NF-κB-responsive,genes
R17395 T21704 T21702 pobj genes,of
R17396 T21705 T21704 punct ",",genes
R17397 T21706 T21704 prep including,genes
R17398 T21707 T21706 pobj MIP-1α,including
R17399 T21708 T21707 punct ",",MIP-1α
R17400 T21709 T21707 conj CSF3,MIP-1α
R17401 T21710 T21709 punct ",",CSF3
R17402 T21711 T21709 conj LTA,CSF3
R17403 T21712 T21711 punct ",",LTA
R17404 T21713 T21711 conj NFKBIA,LTA
R17405 T21714 T21713 cc and,NFKBIA
R17406 T21715 T21713 conj TLR2,NFKBIA
R17407 T21716 T21676 punct .,showed
R17408 T21717 T21722 prep By,observed
R17409 T21718 T21719 compound ChIP,analysis
R17410 T21719 T21717 pobj analysis,By
R17411 T21720 T21722 punct ",",observed
R17412 T21721 T21722 nsubj we,observed
R17413 T21722 T21722 ROOT observed,observed
R17414 T21723 T21725 mark that,increased
R17415 T21724 T21725 nsubj Tat,increased
R17416 T21725 T21722 ccomp increased,observed
R17417 T21726 T21727 det the,recruitment
R17418 T21727 T21725 dobj recruitment,increased
R17419 T21728 T21727 prep of,recruitment
R17420 T21729 T21728 pobj p65,of
R17421 T21730 T21725 prep to,increased
R17422 T21731 T21733 det the,enhancers
R17423 T21732 T21733 amod NF-κB,enhancers
R17424 T21733 T21730 pobj enhancers,to
R17425 T21734 T21733 prep of,enhancers
R17426 T21735 T21737 det the,genes
R17427 T21736 T21737 amod activated,genes
R17428 T21737 T21734 pobj genes,of
R17429 T21738 T21725 punct ",",increased
R17430 T21739 T21725 cc and,increased
R17431 T21740 T21741 auxpass was,recovered
R17432 T21741 T21725 conj recovered,increased
R17433 T21742 T21741 prep at,recovered
R17434 T21743 T21745 det the,sites
R17435 T21744 T21745 amod same,sites
R17436 T21745 T21742 pobj sites,at
R17437 T21746 T21722 punct .,observed
R17438 T21747 T21748 compound RNA,interference
R17439 T21748 T21751 nsubj interference,abolished
R17440 T21749 T21748 prep of,interference
R17441 T21750 T21749 pobj p65,of
R17442 T21751 T21751 ROOT abolished,abolished
R17443 T21752 T21754 det the,occupancy
R17444 T21753 T21754 compound Tat,occupancy
R17445 T21754 T21751 dobj occupancy,abolished
R17446 T21755 T21754 prep of,occupancy
R17447 T21756 T21758 det the,enhancers
R17448 T21757 T21758 amod NF-κB,enhancers
R17449 T21758 T21755 pobj enhancers,of
R17450 T21759 T21751 advcl indicating,abolished
R17451 T21760 T21763 mark that,binding
R17452 T21761 T21762 det the,Tat
R17453 T21762 T21763 nsubj Tat,binding
R17454 T21763 T21759 ccomp binding,indicating
R17455 T21764 T21763 prep to,binding
R17456 T21765 T21767 det the,sites
R17457 T21766 T21767 amod NF-κB,sites
R17458 T21767 T21764 pobj sites,to
R17459 T21768 T21769 auxpass was,mediated
R17460 T21769 T21751 conj mediated,abolished
R17461 T21770 T21769 agent by,mediated
R17462 T21771 T21770 pobj p65,by
R17463 T21772 T21751 punct .,abolished
R17464 T21773 T21774 det These,results
R17465 T21774 T21775 nsubj results,were
R17466 T21775 T21775 ROOT were,were
R17467 T21776 T21775 acomp consistent,were
R17468 T21777 T21776 prep with,consistent
R17469 T21778 T21779 det the,evidence
R17470 T21779 T21777 pobj evidence,with
R17471 T21780 T21782 mark that,displaced
R17472 T21781 T21782 nsubj Tat,displaced
R17473 T21782 T21779 acl displaced,evidence
R17474 T21783 T21782 dobj p65,displaced
R17475 T21784 T21782 prep from,displaced
R17476 T21785 T21786 det the,binding
R17477 T21786 T21784 pobj binding,from
R17478 T21787 T21784 prep to,from
R17479 T21788 T21787 pobj IκB-α,to
R17480 T21789 T21791 punct (,2D
R17481 T21790 T21791 compound Figures,2D
R17482 T21791 T21788 appos 2D,IκB-α
R17483 T21792 T21791 cc and,2D
R17484 T21793 T21791 conj 3C,2D
R17485 T21794 T21791 punct ),2D
R17486 T21795 T21782 punct ",",displaced
R17487 T21796 T21782 cc and,displaced
R17488 T21797 T21775 conj increased,were
R17489 T21798 T21802 det the,affinity
R17490 T21799 T21800 nummod p65,DNA
R17491 T21800 T21802 nmod DNA,affinity
R17492 T21801 T21802 amod binding,affinity
R17493 T21802 T21797 dobj affinity,increased
R17494 T21803 T21797 prep through,increased
R17495 T21804 T21803 pobj association,through
R17496 T21805 T21806 punct (,Figure
R17497 T21806 T21797 npadvmod Figure,increased
R17498 T21807 T21806 nummod 4E,Figure
R17499 T21808 T21806 cc and,Figure
R17500 T21809 T21806 conj F,Figure
R17501 T21810 T21806 punct ),Figure
R17502 T21811 T21775 punct .,were
R17503 T21812 T21816 advmod Thus,increased
R17504 T21813 T21816 punct ",",increased
R17505 T21814 T21815 compound Tat,likely
R17506 T21815 T21816 nsubj likely,increased
R17507 T21816 T21816 ROOT increased,increased
R17508 T21817 T21818 det the,recruitment
R17509 T21818 T21816 dobj recruitment,increased
R17510 T21819 T21818 prep of,recruitment
R17511 T21820 T21819 pobj p65,of
R17512 T21821 T21816 prep to,increased
R17513 T21822 T21824 det the,promoters
R17514 T21823 T21824 amod NF-κB-dependent,promoters
R17515 T21824 T21821 pobj promoters,to
R17516 T21825 T21816 prep by,increased
R17517 T21826 T21825 pcomp associating,by
R17518 T21827 T21826 prep with,associating
R17519 T21828 T21827 pobj p65,with
R17520 T21829 T21825 cc and,by
R17521 T21830 T21825 conj by,by
R17522 T21831 T21830 pcomp interfering,by
R17523 T21832 T21831 prep with,interfering
R17524 T21833 T21834 det the,assembly
R17525 T21834 T21832 pobj assembly,with
R17526 T21835 T21834 prep of,assembly
R17527 T21836 T21835 pobj p65,of
R17528 T21837 T21836 prep with,p65
R17529 T21838 T21840 det the,IκB-α
R17530 T21839 T21840 compound repressor,IκB-α
R17531 T21840 T21837 pobj IκB-α,with
R17532 T21841 T21816 punct .,increased
R17533 T21842 T21847 prep Of,found
R17534 T21843 T21842 pobj interest,Of
R17535 T21844 T21847 punct ",",found
R17536 T21845 T21847 nsubjpass IκB-α,found
R17537 T21846 T21847 auxpass was,found
R17538 T21847 T21847 ROOT found,found
R17539 T21848 T21847 xcomp associated,found
R17540 T21849 T21848 prep to,associated
R17541 T21850 T21852 det the,enhancers
R17542 T21851 T21852 amod NF-κB,enhancers
R17543 T21852 T21849 pobj enhancers,to
R17544 T21853 T21852 prep in,enhancers
R17545 T21854 T21853 pobj absence,in
R17546 T21855 T21854 prep of,absence
R17547 T21856 T21855 pobj Tat,of
R17548 T21857 T21854 punct ",",absence
R17549 T21858 T21861 advmod where,displaced
R17550 T21859 T21861 nsubjpass it,displaced
R17551 T21860 T21861 auxpass was,displaced
R17552 T21861 T21852 relcl displaced,enhancers
R17553 T21862 T21861 prep in,displaced
R17554 T21863 T21862 pobj presence,in
R17555 T21864 T21863 prep of,presence
R17556 T21865 T21864 pobj Tat,of
R17557 T21866 T21847 punct .,found
R17558 T21867 T21868 det These,results
R17559 T21868 T21869 nsubj results,suggest
R17560 T21869 T21869 ROOT suggest,suggest
R17561 T21870 T21873 det a,role
R17562 T21871 T21873 amod negative,role
R17563 T21872 T21873 amod regulatory,role
R17564 T21873 T21869 dobj role,suggest
R17565 T21874 T21873 prep of,role
R17566 T21875 T21874 pobj IκB-α,of
R17567 T21876 T21873 prep in,role
R17568 T21877 T21878 compound gene,regulation
R17569 T21878 T21876 pobj regulation,in
R17570 T21879 T21869 prep through,suggest
R17571 T21880 T21879 pobj occupancy,through
R17572 T21881 T21880 prep of,occupancy
R17573 T21882 T21883 amod specific,promoters
R17574 T21883 T21881 pobj promoters,of
R17575 T21884 T21869 punct .,suggest
R17576 T21885 T21889 advmod Indeed,found
R17577 T21886 T21889 punct ",",found
R17578 T21887 T21889 nsubjpass IκB-α,found
R17579 T21888 T21889 auxpass was,found
R17580 T21889 T21889 ROOT found,found
R17581 T21890 T21889 xcomp associated,found
R17582 T21891 T21890 prep with,associated
R17583 T21892 T21893 compound hystone,deacetylases
R17584 T21893 T21891 pobj deacetylases,with
R17585 T21894 T21890 prep at,associated
R17586 T21895 T21897 det the,promoter
R17587 T21896 T21897 nummod hes1,promoter
R17588 T21897 T21894 pobj promoter,at
R17589 T21898 T21897 punct ",",promoter
R17590 T21899 T21890 prep from,associated
R17591 T21900 T21903 advmod where,removed
R17592 T21901 T21903 nsubjpass it,removed
R17593 T21902 T21903 auxpass was,removed
R17594 T21903 T21890 advcl removed,associated
R17595 T21904 T21903 prep following,removed
R17596 T21905 T21906 amod TNF-α,stimulation
R17597 T21906 T21904 pobj stimulation,following
R17598 T21907 T21906 acl causing,stimulation
R17599 T21908 T21909 compound histone,acetylation
R17600 T21909 T21907 dobj acetylation,causing
R17601 T21910 T21909 cc and,acetylation
R17602 T21911 T21913 nummod hes1,activation
R17603 T21912 T21913 amod transcriptional,activation
R17604 T21913 T21909 conj activation,acetylation
R17605 T21914 T21913 punct (,activation
R17606 T21915 T21913 appos 65,activation
R17607 T21916 T21913 punct ),activation
R17608 T21917 T21889 punct .,found
R17609 T21918 T21920 det A,mechanism
R17610 T21919 T21920 amod similar,mechanism
R17611 T21920 T21925 nsubj mechanism,apply
R17612 T21921 T21920 prep of,mechanism
R17613 T21922 T21923 compound gene,regulation
R17614 T21923 T21921 pobj regulation,of
R17615 T21924 T21925 aux could,apply
R17616 T21925 T21925 ROOT apply,apply
R17617 T21926 T21925 prep to,apply
R17618 T21927 T21929 det the,genes
R17619 T21928 T21929 amod NF-κB-dependent,genes
R17620 T21929 T21926 pobj genes,to
R17621 T21930 T21929 acl analysed,genes
R17622 T21931 T21930 prep in,analysed
R17623 T21932 T21933 det this,study
R17624 T21933 T21931 pobj study,in
R17625 T21934 T21933 punct ",",study
R17626 T21935 T21938 advmod where,activate
R17627 T21936 T21938 nsubj Tat,activate
R17628 T21937 T21938 aux could,activate
R17629 T21938 T21925 advcl activate,apply
R17630 T21939 T21941 det the,expression
R17631 T21940 T21941 compound gene,expression
R17632 T21941 T21938 dobj expression,activate
R17633 T21942 T21938 prep by,activate
R17634 T21943 T21942 pcomp removing,by
R17635 T21944 T21943 dobj IκB-α,removing
R17636 T21945 T21943 cc and,removing
R17637 T21946 T21943 conj promoting,removing
R17638 T21947 T21949 det the,loading
R17639 T21948 T21949 nummod p65,loading
R17640 T21949 T21946 dobj loading,promoting
R17641 T21950 T21951 punct (,Figure
R17642 T21951 T21949 appos Figure,loading
R17643 T21952 T21951 nummod 7,Figure
R17644 T21953 T21951 punct ),Figure
R17645 T21954 T21925 punct .,apply
R17646 T21955 T21957 det The,relevance
R17647 T21956 T21957 amod physiological,relevance
R17648 T21957 T21965 nsubjpass relevance,demonstrated
R17649 T21958 T21957 prep of,relevance
R17650 T21959 T21958 pobj Tat,of
R17651 T21960 T21965 nsubjpass cross,demonstrated
R17652 T21961 T21960 dobj talk,cross
R17653 T21962 T21961 prep with,talk
R17654 T21963 T21962 pobj NF-κB,with
R17655 T21964 T21965 auxpass was,demonstrated
R17656 T21965 T21992 parataxis demonstrated,sustained
R17657 T21966 T21965 prep in,demonstrated
R17658 T21967 T21969 det the,infection
R17659 T21968 T21969 compound HIV-1,infection
R17660 T21969 T21966 pobj infection,in
R17661 T21970 T21969 prep of,infection
R17662 T21971 T21972 amod human,monocytes
R17663 T21972 T21970 pobj monocytes,of
R17664 T21973 T21972 punct ",",monocytes
R17665 T21974 T21978 advmod where,counteracted
R17666 T21975 T21977 amod HIV-1-encoded,protein
R17667 T21976 T21977 compound Tat,protein
R17668 T21977 T21978 nsubj protein,counteracted
R17669 T21978 T21969 relcl counteracted,infection
R17670 T21979 T21980 amod post-activation,turn
R17671 T21980 T21981 compound turn,off
R17672 T21981 T21978 prep off,counteracted
R17673 T21982 T21981 prep of,off
R17674 T21983 T21982 pobj NF-κB,of
R17675 T21984 T21965 punct ",",demonstrated
R17676 T21985 T21986 mark as,shown
R17677 T21986 T21965 advcl shown,demonstrated
R17678 T21987 T21986 agent by,shown
R17679 T21988 T21987 punct :,by
R17680 T21989 T21990 punct (,i
R17681 T21990 T21987 pobj i,by
R17682 T21991 T21965 punct ),demonstrated
R17683 T21992 T22005 ccomp sustained,ii
R17684 T21993 T21994 amod NF-κB,activity
R17685 T21994 T21992 dobj activity,sustained
R17686 T21995 T21992 prep by,sustained
R17687 T21996 T21995 pobj Tat,by
R17688 T21997 T21992 prep in,sustained
R17689 T21998 T21997 pobj presence,in
R17690 T21999 T21998 prep of,presence
R17691 T22000 T22001 advmod newly,synthesized
R17692 T22001 T22002 amod synthesized,IκB-α
R17693 T22002 T21999 pobj IκB-α,of
R17694 T22003 T22005 punct ;,ii
R17695 T22004 T22005 punct (,ii
R17696 T22005 T22005 ROOT ii,ii
R17697 T22006 T22005 punct ),ii
R17698 T22007 T22007 ROOT coimmunoprecipitation,coimmunoprecipitation
R17699 T22008 T22007 prep of,coimmunoprecipitation
R17700 T22009 T22008 pobj Tat,of
R17701 T22010 T22007 prep with,coimmunoprecipitation
R17702 T22011 T22010 pobj IκB-α,with
R17703 T22012 T22011 cc and,IκB-α
R17704 T22013 T22011 conj p65,IκB-α
R17705 T22014 T22007 punct ;,coimmunoprecipitation
R17706 T22015 T22016 punct (,iii
R17707 T22016 T22007 parataxis iii,coimmunoprecipitation
R17708 T22017 T22016 punct ),iii
R17709 T22018 T22007 conj induction,coimmunoprecipitation
R17710 T22019 T22018 prep of,induction
R17711 T22020 T22021 amod MIP-1α,expression
R17712 T22021 T22019 pobj expression,of
R17713 T22022 T22007 amod dependent,coimmunoprecipitation
R17714 T22023 T22022 prep on,dependent
R17715 T22024 T22023 pobj Tat,on
R17716 T22025 T22024 cc and,Tat
R17717 T22026 T22024 conj p65,Tat
R17718 T22027 T22007 punct ;,coimmunoprecipitation
R17719 T22028 T22029 punct (,iv
R17720 T22029 T22007 appos iv,coimmunoprecipitation
R17721 T22030 T22029 punct ),iv
R17722 T22031 T22032 compound Tat,occupancy
R17723 T22032 T22007 appos occupancy,coimmunoprecipitation
R17724 T22033 T22032 prep of,occupancy
R17725 T22034 T22037 det the,enhancer
R17726 T22035 T22037 compound MIP-1α,enhancer
R17727 T22036 T22037 compound NF-κB,enhancer
R17728 T22037 T22033 pobj enhancer,of
R17729 T22038 T22032 acl associated,occupancy
R17730 T22039 T22038 prep with,associated
R17731 T22040 T22041 amod increased,recruitment
R17732 T22041 T22039 pobj recruitment,with
R17733 T22042 T22041 prep of,recruitment
R17734 T22043 T22042 pobj p65,of
R17735 T22044 T22007 punct .,coimmunoprecipitation
R17736 T22045 T22046 det This,study
R17737 T22046 T22047 nsubj study,supports
R17738 T22047 T22047 ROOT supports,supports
R17739 T22048 T22050 det the,action
R17740 T22049 T22050 amod pro-inflammatory,action
R17741 T22050 T22047 dobj action,supports
R17742 T22051 T22050 prep of,action
R17743 T22052 T22051 pobj Tat,of
R17744 T22053 T22050 prep through,action
R17745 T22054 T22055 amod physical,interaction
R17746 T22055 T22053 pobj interaction,through
R17747 T22056 T22055 prep with,interaction
R17748 T22057 T22056 pobj p65,with
R17749 T22058 T22057 cc and,p65
R17750 T22059 T22057 conj IκB-α,p65
R17751 T22060 T22047 punct .,supports
R17752 T22061 T22063 amod Several,cytokines
R17753 T22062 T22063 amod inflammatory,cytokines
R17754 T22063 T22070 nsubj cytokines,are
R17755 T22064 T22063 prep under,cytokines
R17756 T22065 T22067 det the,control
R17757 T22066 T22067 amod transcriptional,control
R17758 T22067 T22064 pobj control,under
R17759 T22068 T22067 prep of,control
R17760 T22069 T22068 pobj NF-κB,of
R17761 T22070 T22070 ROOT are,are
R17762 T22071 T22070 acomp hyper-expressed,are
R17763 T22072 T22071 prep in,hyper-expressed
R17764 T22073 T22075 amod HIV-1,individuals
R17765 T22074 T22075 amod infected,individuals
R17766 T22075 T22072 pobj individuals,in
R17767 T22076 T22075 punct ",",individuals
R17768 T22077 T22075 prep including,individuals
R17769 T22078 T22077 pobj IL-6,including
R17770 T22079 T22078 punct (,IL-6
R17771 T22080 T22078 appos "66,67",IL-6
R17772 T22081 T22078 punct ),IL-6
R17773 T22082 T22078 punct ",",IL-6
R17774 T22083 T22078 conj TNF-α,IL-6
R17775 T22084 T22083 punct (,TNF-α
R17776 T22085 T22083 appos 68,TNF-α
R17777 T22086 T22083 punct ),TNF-α
R17778 T22087 T22070 punct ",",are
R17779 T22088 T22070 cc and,are
R17780 T22089 T22070 conj MIP-1α,are
R17781 T22090 T22089 punct (,MIP-1α
R17782 T22091 T22089 appos 57,MIP-1α
R17783 T22092 T22089 appos "62,69",MIP-1α
R17784 T22093 T22089 appos 71,MIP-1α
R17785 T22094 T22089 punct ),MIP-1α
R17786 T22095 T22070 punct .,are
R17787 T22096 T22105 prep In,activated
R17788 T22097 T22098 det the,case
R17789 T22098 T22096 pobj case,In
R17790 T22099 T22098 prep of,case
R17791 T22100 T22099 pobj TNF-α,of
R17792 T22101 T22100 cc and,TNF-α
R17793 T22102 T22100 conj IL-6,TNF-α
R17808 T22117 T22120 det the,transcript
R17809 T22118 T22119 nummod 5,′
R17810 T22119 T22120 compound ′,transcript
R17811 T22120 T22116 pobj transcript,of
R17812 T22121 T22105 punct ",",activated
R17813 T22122 T22123 advmod thus,likely
R17814 T22123 T22105 advcl likely,activated
R17815 T22124 T22123 xcomp promoting,likely
R17816 T22125 T22127 det the,elongation
R17817 T22126 T22127 amod transcriptional,elongation
R17818 T22127 T22124 dobj elongation,promoting
R17819 T22128 T22127 punct (,elongation
R17820 T22129 T22127 appos "33,37,47",elongation
R17821 T22130 T22127 punct ),elongation
R17822 T22131 T22105 punct .,activated
R17823 T22132 T22136 advmod Here,shown
R17824 T22133 T22136 punct ",",shown
R17825 T22134 T22136 nsubj we,shown
R17826 T22135 T22136 aux have,shown
R17827 T22136 T22136 ROOT shown,shown
R17828 T22137 T22148 mark that,required
R17829 T22138 T22141 det the,activation
R17830 T22139 T22141 amod Tat-dependent,activation
R17832 T22141 T22148 nsubj activation,required
R17833 T22142 T22141 prep of,activation
R17834 T22143 T22144 det a,number
R17835 T22144 T22142 pobj number,of
R17836 T22145 T22144 prep of,number
R17837 T22146 T22147 amod pro-inflammatory,genes
R17838 T22147 T22145 pobj genes,of
R17839 T22148 T22136 ccomp required,shown
R17840 T22149 T22150 det the,assembly
R17841 T22150 T22148 dobj assembly,required
R17842 T22151 T22150 prep of,assembly
R17843 T22152 T22151 pobj Tat,of
R17844 T22153 T22148 prep with,required
R17845 T22154 T22153 pobj p65,with
R17846 T22155 T22154 prep at,p65
R17847 T22156 T22158 det the,enhancer
R17848 T22157 T22158 compound NF-κB,enhancer
R17849 T22158 T22155 pobj enhancer,at
R17850 T22159 T22160 advmod together,with
R17851 T22160 T22148 prep with,required
R17852 T22161 T22162 det the,displacement
R17853 T22162 T22160 pobj displacement,with
R17854 T22163 T22162 prep of,displacement
R17855 T22164 T22163 pobj IκB-α,of
R17856 T22165 T22166 punct (,Figure
R17857 T22166 T22164 appos Figure,IκB-α
R17858 T22167 T22166 nummod 5,Figure
R17859 T22168 T22164 punct ),IκB-α
R17860 T22169 T22136 punct .,shown
R17861 T22170 T22181 advmod Thus,acted
R17862 T22171 T22181 punct ",",acted
R17863 T22172 T22181 prep in,acted
R17864 T22173 T22174 det the,set
R17865 T22174 T22172 pobj set,in
R17866 T22175 T22174 prep of,set
R17867 T22176 T22178 amod distinct,genes
R17868 T22177 T22178 amod NF-κB-responsive,genes
R17869 T22178 T22175 pobj genes,of
R17870 T22179 T22181 punct ",",acted
R17871 T22180 T22181 nsubj Tat,acted
R17872 T22181 T22181 ROOT acted,acted
R17873 T22182 T22181 prep as,acted
R17874 T22183 T22184 det a,component
R17875 T22184 T22182 pobj component,as
R17876 T22185 T22184 prep of,component
R17877 T22186 T22189 det the,complex
R17878 T22187 T22189 compound transcriptional,complex
R17879 T22188 T22189 compound initiation,complex
R17880 T22189 T22185 pobj complex,of
R17881 T22190 T22184 punct ",",component
R17882 T22191 T22192 nsubj which,is
R17883 T22192 T22184 relcl is,component
R17884 T22193 T22192 acomp consistent,is
R17885 T22194 T22193 prep with,consistent
R17886 T22195 T22196 amod previous,reports
R17887 T22196 T22194 pobj reports,with
R17888 T22197 T22196 prep on,reports
R17889 T22198 T22197 pobj Tat,on
R17890 T22199 T22196 acl promoting,reports
R17891 T22200 T22201 det the,transcription
R17892 T22201 T22199 dobj transcription,promoting
R17893 T22202 T22199 prep via,promoting
R17894 T22203 T22204 compound DNA,motifs
R17895 T22204 T22202 pobj motifs,via
R17896 T22205 T22204 punct (,motifs
R17897 T22206 T22204 appos "72,73",motifs
R17898 T22207 T22204 punct ),motifs
R17899 T22208 T22181 punct .,acted
R17900 T22209 T22214 nsubjpass Overproduction,considered
R17901 T22210 T22209 prep of,Overproduction
R17902 T22211 T22212 amod pro-inflammatory,cytokines
R17903 T22212 T22210 pobj cytokines,of
R17904 T22213 T22214 auxpass is,considered
R17905 T22214 T22214 ROOT considered,considered
R17906 T22215 T22217 det a,mechanism
R17907 T22216 T22217 amod major,mechanism
R17908 T22217 T22214 oprd mechanism,considered
R17909 T22218 T22217 prep of,mechanism
R17910 T22219 T22220 amod immune,deregulation
R17911 T22220 T22218 pobj deregulation,of
R17912 T22221 T22220 punct (,deregulation
R17913 T22222 T22220 appos 26,deregulation
R17914 T22223 T22220 punct ),deregulation
R17915 T22224 T22220 cc and,deregulation
R17916 T22225 T22226 compound neuron,dysfunction
R17917 T22226 T22217 conj dysfunction,mechanism
R17918 T22227 T22217 prep in,mechanism
R17919 T22228 T22227 pobj AIDS,in
R17920 T22229 T22230 punct (,"74,75"
R17921 T22230 T22217 appos "74,75",mechanism
R17922 T22231 T22214 punct ),considered
R17923 T22232 T22214 punct .,considered
R17924 T22233 T22242 prep In,lead
R17925 T22234 T22235 det this,scenario
R17926 T22235 T22233 pobj scenario,In
R17927 T22236 T22242 punct ",",lead
R17928 T22237 T22242 nsubj inhibition,lead
R17929 T22238 T22237 prep of,inhibition
R17930 T22239 T22240 amod NF-κB,activity
R17931 T22240 T22238 pobj activity,of
R17932 T22241 T22242 aux could,lead
R17933 T22242 T22242 ROOT lead,lead
R17934 T22243 T22242 prep to,lead
R17935 T22244 T22246 det a,strategy
R17936 T22245 T22246 amod therapeutic,strategy
R17937 T22246 T22243 pobj strategy,to
R17938 T22247 T22246 prep for,strategy
R17962 T22271 T22268 conj inhibitors,proteasome
R17963 T22272 T22262 punct ",",inhibitors
R17964 T22273 T22274 advmod significantly,reduced
R17965 T22274 T22292 ccomp reduced,acted
R17966 T22275 T22277 det the,replication
R17967 T22276 T22277 compound HIV-1,replication
R17968 T22277 T22274 dobj replication,reduced
R17969 T22278 T22277 cc and,replication
R17970 T22279 T22282 det the,response
R17971 T22280 T22282 amod associated,response
R17972 T22281 T22282 amod inflammatory,response
R17973 T22282 T22277 conj response,replication
R17974 T22283 T22282 punct (,response
R17975 T22284 T22282 appos "76,77",response
R17976 T22285 T22274 punct ),reduced
R17977 T22286 T22292 punct ;,acted
R17978 T22287 T22292 advmod however,acted
R17979 T22288 T22292 punct ",",acted
R17980 T22289 T22291 det these,inhibitors
R17981 T22290 T22291 amod NF-κB,inhibitors
R17982 T22291 T22292 nsubj inhibitors,acted
R17983 T22292 T22292 ROOT acted,acted
R17984 T22293 T22292 advmod indiscriminately,acted
R17985 T22294 T22292 prep in,acted
R17986 T22295 T22296 preconj both,HIV-1-infected
R17987 T22296 T22299 amod HIV-1-infected,cells
R17988 T22297 T22296 cc and,HIV-1-infected
R17989 T22298 T22296 conj uninfected,HIV-1-infected
R17990 T22299 T22294 pobj cells,in
R17991 T22300 T22292 punct .,acted
R17992 T22301 T22302 det The,evidence
R17993 T22302 T22302 ROOT evidence,evidence
R17994 T22303 T22305 mark that,activates
R17995 T22304 T22305 nsubj Tat,activates
R17996 T22305 T22302 acl activates,evidence
R17997 T22306 T22305 dobj NF-κB,activates
R17998 T22307 T22305 prep through,activates
R17999 T22308 T22309 amod direct,interaction
R18000 T22309 T22307 pobj interaction,through
R18001 T22310 T22309 prep with,interaction
R18002 T22311 T22310 pobj IκB-α,with
R18003 T22312 T22311 cc and,IκB-α
R18004 T22313 T22311 conj p65,IκB-α
R18005 T22314 T22315 aux may,lead
R18006 T22315 T22305 conj lead,activates
R18007 T22316 T22315 prep to,lead
R18008 T22317 T22318 amod specific,inhibitors
R18009 T22318 T22316 pobj inhibitors,to
R18010 T22319 T22320 aux to,counteract
R18011 T22320 T22315 xcomp counteract,lead
R18012 T22321 T22324 det the,action
R18013 T22322 T22324 nmod Tat,action
R18014 T22323 T22324 amod pro-inflammatory,action
R18015 T22324 T22320 dobj action,counteract
R18016 T22325 T22302 punct .,evidence
R19067 T23945 T23946 nsubj Tat,counteracts
R19068 T23946 T23946 ROOT counteracts,counteracts
R19069 T23947 T23949 det the,turn
R19070 T23948 T23949 amod post-activation,turn
R19071 T23949 T23946 dobj turn,counteracts
R19072 T23950 T23949 prt off,turn
R19073 T23951 T23949 prep of,turn
R19074 T23952 T23951 pobj NF-κB,of
R19075 T23953 T23949 prep in,turn
R19076 T23954 T23956 amod single,HIV-1-infection
R19077 T23955 T23956 compound round,HIV-1-infection
R19078 T23956 T23953 pobj HIV-1-infection,in
R19079 T23957 T23946 punct .,counteracts
R19080 T23958 T23959 compound Jurkat,cells
R19081 T23959 T23966 nsubjpass cells,transfected
R19082 T23960 T23959 punct (,cells
R19083 T23961 T23963 quantmod 5,107
R19084 T23962 T23963 quantmod ×,107
R19085 T23963 T23959 appos 107,cells
R19086 T23964 T23959 punct ),cells
R19087 T23965 T23966 auxpass were,transfected
R19088 T23966 T23988 ccomp transfected,infected
R19089 T23967 T23966 prep with,transfected
R19090 T23968 T23969 compound siRNA,Tat
R19091 T23969 T23967 pobj Tat,with
R19092 T23970 T23969 cc or,Tat
R19093 T23971 T23972 compound siRNA,control
R19094 T23972 T23969 conj control,Tat
R19095 T23973 T23972 punct (,control
R19096 T23974 T23975 nummod 2,nmol
R19097 T23975 T23972 appos nmol,control
R19098 T23976 T23972 punct ),control
R19099 T23977 T23972 punct ",",control
R19100 T23978 T23966 cc or,transfected
R19101 T23979 T23966 conj left,transfected
R19102 T23980 T23979 oprd untransfected,left
R19103 T23981 T23988 punct ;,infected
R19104 T23982 T23983 nummod 24,h
R19105 T23983 T23984 npadvmod h,later
R19106 T23984 T23988 advmod later,infected
R19107 T23985 T23988 punct ",",infected
R19108 T23986 T23988 nsubjpass cells,infected
R19109 T23987 T23988 auxpass were,infected
R19110 T23988 T23988 ROOT infected,infected
R19111 T23989 T23988 prep with,infected
R19112 T23990 T23991 amod HXB2-pseudotyped,NL4-3
R19113 T23991 T23989 pobj NL4-3,with
R19114 T23992 T23988 punct .,infected
R19115 T23993 T23997 compound Luc.R,virions
R19116 T23994 T23997 compound −,virions
R19117 T23995 T23996 compound E,−
R19118 T23996 T23997 compound −,virions
R19119 T23997 T24005 nsubj virions,harvested
R19120 T23998 T24000 punct (,ng
R19121 T23999 T24000 nummod 500,ng
R19122 T24000 T23997 appos ng,virions
R19123 T24001 T24000 prep of,ng
R19124 T24002 T24001 pobj p24,of
R19125 T24003 T24000 punct ),ng
R19126 T24004 T23997 cc and,virions
R19127 T24005 T24005 ROOT harvested,harvested
R19128 T24006 T24005 prep at,harvested
R19129 T24007 T24009 det the,time
R19130 T24008 T24009 amod indicated,time
R19131 T24009 T24006 pobj time,at
R19132 T24010 T24005 punct .,harvested
R19133 T24011 T24011 ROOT (,(
R19134 T24012 T24011 dep A,(
R19135 T24013 T24012 punct ),A
R19136 T24014 T24015 compound Tat,expression
R19137 T24015 T24017 nsubjpass expression,measured
R19138 T24016 T24017 auxpass was,measured
R19139 T24017 T24017 ROOT measured,measured
R19140 T24018 T24017 prep in,measured
R19141 T24019 T24020 amod total,RNA
R19142 T24020 T24018 pobj RNA,in
R19143 T24021 T24017 agent by,measured
R19144 T24022 T24023 amod real-time,PCR
R19145 T24023 T24021 pobj PCR,by
R19146 T24024 T24017 punct ",",measured
R19147 T24025 T24030 mark while,measured
R19148 T24026 T24028 det the,activity
R19149 T24027 T24028 compound luciferase,activity
R19150 T24028 T24030 nsubjpass activity,measured
R19151 T24029 T24030 auxpass was,measured
R19152 T24030 T24017 advcl measured,measured
R19153 T24031 T24030 prep in,measured
R19154 T24032 T24034 amod whole,extracts
R19155 T24033 T24034 compound cell,extracts
R19156 T24034 T24031 pobj extracts,in
R19157 T24035 T24017 punct .,measured
R19158 T24036 T24045 punct (,were
R19159 T24037 T24040 compound B,extracts
R19160 T24038 T24039 punct ),Nuclear
R19161 T24039 T24040 compound Nuclear,extracts
R19162 T24040 T24045 nsubj extracts,were
R19163 T24041 T24040 punct (,extracts
R19164 T24042 T24043 nummod 10,µg
R19165 T24043 T24040 appos µg,extracts
R19166 T24044 T24040 punct ),extracts
R19167 T24045 T24045 ROOT were,were
R19168 T24046 T24045 attr analysed,were
R19169 T24047 T24046 prep for,analysed
R19170 T24048 T24049 det the,p65
R19171 T24049 T24047 pobj p65,for
R19172 T24050 T24049 cc and,p65
R19173 T24051 T24052 amod p50,binding
R19174 T24052 T24045 acomp binding,were
R19175 T24053 T24052 prep to,binding
R19176 T24054 T24057 det the,oligonucleotide
R19177 T24055 T24057 nmod NF-κB,oligonucleotide
R19178 T24056 T24057 amod double-stranded,oligonucleotide
R19179 T24057 T24053 pobj oligonucleotide,to
R19180 T24058 T24045 advcl using,were
R19181 T24059 T24065 det the,kit
R19182 T24060 T24065 compound NF-κB,kit
R19183 T24061 T24065 compound Transcription,kit
R19184 T24062 T24064 compound Factor,Assay
R19185 T24063 T24064 compound ELISA,Assay
R19186 T24064 T24065 compound Assay,kit
R19187 T24065 T24058 dobj kit,using
R19188 T24066 T24065 punct (,kit
R19189 T24067 T24065 appos Cayman,kit
R19190 T24068 T24065 punct ),kit
R19191 T24069 T24045 punct .,were
R19192 T24070 T24071 punct (,C
R19193 T24071 T24071 ROOT C,C
R19194 T24072 T24071 punct ),C
R19195 T24073 T24074 det The,expression
R19196 T24074 T24080 nsubjpass expression,analysed
R19197 T24075 T24074 prep of,expression
R19198 T24076 T24075 pobj p65,of
R19199 T24077 T24076 cc and,p65
R19200 T24078 T24075 pobj IκB-α,of
R19201 T24079 T24080 auxpass was,analysed
R19202 T24080 T24080 ROOT analysed,analysed
R19203 T24081 T24080 agent by,analysed
R19204 T24082 T24083 nummod 12,%
R19205 T24083 T24084 compound %,SDS
R19206 T24084 T24081 pobj SDS,by
R19207 T24085 T24084 conj PAGE,SDS
R19208 T24086 T24085 cc and,PAGE
R19209 T24087 T24088 amod western,blotting
R19210 T24088 T24085 conj blotting,PAGE
R19211 T24089 T24088 prep of,blotting
R19212 T24090 T24093 amod nuclear,extracts
R19213 T24091 T24090 cc or,nuclear
R19214 T24092 T24090 conj cytosolic,nuclear
R19215 T24093 T24089 pobj extracts,of
R19216 T24094 T24093 punct (,extracts
R19217 T24095 T24096 nummod 20,µg
R19218 T24096 T24093 appos µg,extracts
R19219 T24097 T24096 punct ),µg
R19220 T24098 T24088 advcl using,blotting
R19221 T24099 T24102 amod anti-p65,antibodies
R19222 T24100 T24099 cc and,anti-p65
R19223 T24101 T24099 conj anti-IκB-α,anti-p65
R19224 T24102 T24098 dobj antibodies,using
R19225 T24103 T24080 punct .,analysed
R19226 T24104 T24105 compound Histone,H1
R19227 T24105 T24110 nsubjpass H1,detected
R19228 T24106 T24105 cc and,H1
R19229 T24107 T24108 compound Hexokinase,II
R19230 T24108 T24105 conj II,H1
R19231 T24109 T24110 auxpass were,detected
R19232 T24110 T24110 ROOT detected,detected
R19233 T24111 T24110 prep with,detected
R19234 T24112 T24113 amod specific,antibodies
R19235 T24113 T24111 pobj antibodies,with
R19236 T24114 T24113 prep as,antibodies
R19237 T24115 T24114 pobj markers,as
R19238 T24116 T24115 prep of,markers
R19239 T24117 T24120 amod nuclear,extracts
R19240 T24118 T24117 cc and,nuclear
R19241 T24119 T24117 conj cytosolic,nuclear
R19242 T24120 T24116 pobj extracts,of
R19243 T24121 T24120 punct ",",extracts
R19244 T24122 T24110 advmod respectively,detected
R19245 T24123 T24110 punct .,detected
R19246 T24124 T24125 compound Densitometry,values
R19247 T24125 T24133 nsubjpass values,expressed
R19248 T24126 T24127 punct (,D
R19249 T24127 T24125 appos D,values
R19250 T24128 T24125 punct ),values
R19251 T24129 T24125 prep of,values
R19252 T24130 T24131 det the,bands
R19253 T24131 T24129 pobj bands,of
R19254 T24132 T24133 auxpass were,expressed
R19255 T24133 T24133 ROOT expressed,expressed
R19256 T24134 T24133 prep as,expressed
R19257 T24135 T24136 compound fold,increase
R19258 T24136 T24134 pobj increase,as
R19259 T24137 T24136 prep above,increase
R19260 T24138 T24139 det the,control
R19261 T24139 T24137 pobj control,above
R19262 T24140 T24139 punct (,control
R19263 T24141 T24139 amod mock,control
R19264 T24142 T24139 punct ),control
R19265 T24143 T24133 punct .,expressed
R19266 T24144 T24150 punct (,measured
R19267 T24145 T24148 compound D,activity
R19268 T24146 T24147 punct ),IKK
R19269 T24147 T24148 compound IKK,activity
R19270 T24148 T24150 nsubjpass activity,measured
R19271 T24149 T24150 auxpass was,measured
R19272 T24150 T24150 ROOT measured,measured
R19273 T24151 T24150 prep in,measured
R19274 T24152 T24153 amod cytosolic,extracts
R19275 T24153 T24151 pobj extracts,in
R19276 T24154 T24153 punct (,extracts
R19277 T24155 T24156 nummod 100,µg
R19278 T24156 T24153 appos µg,extracts
R19279 T24157 T24153 punct ),extracts
R19280 T24158 T24150 prep by,measured
R19281 T24159 T24158 pcomp using,by
R19282 T24160 T24163 compound HTScan,Assay
R19283 T24161 T24163 compound IKK,Assay
R19284 T24162 T24163 compound Kinase,Assay
R19285 T24163 T24159 dobj Assay,using
R19286 T24164 T24167 punct (,Technology
R19287 T24165 T24167 compound Cell,Technology
R19288 T24166 T24167 compound Signaling,Technology
R19289 T24167 T24163 appos Technology,Assay
R19290 T24168 T24163 punct ),Assay
R19291 T24169 T24150 punct .,measured
R19292 T24170 T24181 nsubjpass Values,shown
R19293 T24171 T24170 punct (,Values
R19294 T24172 T24174 amod mean,SE
R19295 T24173 T24174 compound ±,SE
R19296 T24174 T24170 appos SE,Values
R19297 T24175 T24174 punct ",",SE
R19298 T24176 T24181 nsubjpass n,shown
R19299 T24177 T24178 punct =,3
R19300 T24178 T24176 advmod 3,n
R19301 T24179 T24181 punct ),shown
R19302 T24180 T24181 auxpass are,shown
R19303 T24181 T24181 ROOT shown,shown
R19304 T24182 T24181 punct .,shown
R19662 T24672 T24673 nsubj Tat,enhances
R19663 T24673 T24673 ROOT enhances,enhances
R19664 T24674 T24676 det the,activity
R19665 T24675 T24676 amod NF-κB,activity
R19666 T24676 T24673 dobj activity,enhances
R19667 T24677 T24676 prep following,activity
R19668 T24678 T24679 compound PMA,stimulation
R19669 T24679 T24677 pobj stimulation,following
R19670 T24680 T24673 prep by,enhances
R19671 T24681 T24680 pcomp associating,by
R19672 T24682 T24681 prep with,associating
R19673 T24683 T24682 pobj IκB-α,with
R19674 T24684 T24681 cc and,associating
R19675 T24685 T24681 conj counteracting,associating
R19676 T24686 T24688 det the,repression
R19677 T24687 T24688 amod NF-κB,repression
R19678 T24688 T24685 dobj repression,counteracting
R19679 T24689 T24673 punct .,enhances
R19680 T24690 T24691 compound HeLa,cells
R19681 T24691 T24698 nsubjpass cells,transfected
R19682 T24692 T24691 punct (,cells
R19683 T24693 T24695 nummod 5,106
R19684 T24694 T24695 nummod ×,106
R19685 T24695 T24691 appos 106,cells
R19686 T24696 T24691 punct ),cells
R19687 T24697 T24698 auxpass were,transfected
R19688 T24698 T24698 ROOT transfected,transfected
R19689 T24699 T24698 prep with,transfected
R19690 T24700 T24699 pobj p3xFLAG-Tat,with
R19691 T24701 T24700 cc or,p3xFLAG-Tat
R19692 T24702 T24700 conj p3xFLAG,p3xFLAG-Tat
R19693 T24703 T24704 amod empty,vector
R19694 T24704 T24702 appos vector,p3xFLAG
R19695 T24705 T24704 punct (,vector
R19696 T24706 T24707 nummod 5,µg
R19697 T24707 T24704 appos µg,vector
R19698 T24708 T24704 punct ),vector
R19699 T24709 T24702 punct ",",p3xFLAG
R19700 T24710 T24702 cc and,p3xFLAG
R19701 T24711 T24712 nummod 48,h
R19702 T24712 T24713 npadvmod h,later
R19703 T24713 T24715 advmod later,stimulated
R19704 T24714 T24715 auxpass were,stimulated
R19705 T24715 T24698 advcl stimulated,transfected
R19706 T24716 T24715 prep with,stimulated
R19707 T24717 T24716 pobj PMA,with
R19708 T24718 T24717 punct (,PMA
R19709 T24719 T24720 nummod 5,min
R19710 T24720 T24717 appos min,PMA
R19711 T24721 T24720 punct ",",min
R19712 T24722 T24723 nummod 20,ng/ml
R19713 T24723 T24720 appos ng/ml,min
R19714 T24724 T24720 punct ),min
R19715 T24725 T24720 cc or,min
R19716 T24726 T24698 conj left,transfected
R19717 T24727 T24726 oprd unstimulated,left
R19718 T24728 T24729 punct ",",washed
R19719 T24729 T24698 conj washed,transfected
R19720 T24730 T24729 advmod twice,washed
R19721 T24731 T24729 prep with,washed
R19722 T24732 T24731 pobj DMEM,with
R19723 T24733 T24729 cc and,washed
R19724 T24734 T24729 conj harvested,washed
R19725 T24735 T24734 prep at,harvested
R19726 T24736 T24738 det the,times
R19727 T24737 T24738 amod indicated,times
R19728 T24738 T24735 pobj times,at
R19729 T24739 T24729 punct .,washed
R19730 T24740 T24743 amod Nuclear,extracts
R19731 T24741 T24740 cc and,Nuclear
R19732 T24742 T24740 conj cytosolic,Nuclear
R19733 T24743 T24745 nsubjpass extracts,prepared
R19734 T24744 T24745 auxpass were,prepared
R19735 T24745 T24745 ROOT prepared,prepared
R19736 T24746 T24745 prep for,prepared
R19737 T24747 T24748 amod further,analysis
R19738 T24748 T24746 pobj analysis,for
R19739 T24749 T24745 punct .,prepared
R19740 T24750 T24756 punct (,analysed
R19741 T24751 T24754 nmod A,extracts
R19742 T24752 T24751 punct ),A
R19743 T24753 T24754 compound Nuclear,extracts
R19744 T24754 T24756 nsubjpass extracts,analysed
R19745 T24755 T24756 auxpass were,analysed
R19746 T24756 T24756 ROOT analysed,analysed
R19747 T24757 T24756 prep for,analysed
R19748 T24758 T24759 det the,p65
R19749 T24759 T24757 pobj p65,for
R19750 T24760 T24759 punct ",",p65
R19751 T24761 T24759 amod p50,p65
R19752 T24762 T24761 cc and,p50
R19753 T24763 T24761 conj FLAG-Tat,p50
R19754 T24764 T24756 oprd binding,analysed
R19755 T24765 T24764 prep to,binding
R19756 T24766 T24769 det the,oligonucleotide
R19757 T24767 T24769 nmod NF-κB,oligonucleotide
R19758 T24768 T24769 amod double-stranded,oligonucleotide
R19759 T24769 T24765 pobj oligonucleotide,to
R19760 T24770 T24756 advcl using,analysed
R19761 T24771 T24777 det the,kit
R19762 T24772 T24775 compound NF-κB,ELISA
R19763 T24773 T24775 compound Transcription,ELISA
R19764 T24774 T24775 compound Factor,ELISA
R19765 T24775 T24777 compound ELISA,kit
R19766 T24776 T24777 compound assay,kit
R19767 T24777 T24770 dobj kit,using
R19768 T24778 T24777 punct (,kit
R19769 T24779 T24777 appos Cayman,kit
R19770 T24780 T24777 punct ),kit
R19771 T24781 T24756 punct .,analysed
R19772 T24782 T24785 punct (,Nuclear
R19773 T24783 T24785 nmod B,Nuclear
R19774 T24784 T24785 punct ),Nuclear
R19775 T24785 T24788 nmod Nuclear,extracts
R19776 T24786 T24785 cc and,Nuclear
R19777 T24787 T24785 conj cytosolic,Nuclear
R19778 T24788 T24794 nsubjpass extracts,separated
R19779 T24789 T24788 punct (,extracts
R19780 T24790 T24791 nummod 20,µg
R19781 T24791 T24788 appos µg,extracts
R19782 T24792 T24788 punct ),extracts
R19783 T24793 T24794 auxpass were,separated
R19784 T24794 T24794 ROOT separated,separated
R19785 T24795 T24794 prep by,separated
R19786 T24796 T24797 nummod 12,%
R19787 T24797 T24798 compound %,SDS
R19788 T24798 T24795 pobj SDS,by
R19789 T24799 T24798 conj PAGE,SDS
R19790 T24800 T24794 cc and,separated
R19791 T24801 T24794 conj analysed,separated
R19792 T24802 T24801 agent by,analysed
R19793 T24803 T24804 amod western,blotting
R19794 T24804 T24802 pobj blotting,by
R19795 T24805 T24801 advcl using,analysed
R19796 T24806 T24812 det the,H1
R19797 T24807 T24812 amod anti-p65,H1
R19798 T24808 T24812 punct ",",H1
R19799 T24809 T24812 amod anti-FLAG,H1
R19800 T24810 T24812 punct ",",H1
R19801 T24811 T24812 amod anti-Histone,H1
R19802 T24812 T24805 dobj H1,using
R19803 T24813 T24812 punct ",",H1
R19804 T24814 T24812 conj anti-IκB-α,H1
R19805 T24815 T24814 cc and,anti-IκB-α
R19806 T24816 T24814 conj anti-Hexokinase-II,anti-IκB-α
R19807 T24817 T24812 conj antibodies,H1
R19808 T24818 T24794 punct .,separated
R19809 T24819 T24820 compound Densitometry,values
R19810 T24820 T24828 nsubjpass values,expressed
R19811 T24821 T24822 punct (,D
R19812 T24822 T24820 appos D,values
R19813 T24823 T24822 punct ),D
R19814 T24824 T24822 prep of,D
R19815 T24825 T24826 det the,bands
R19816 T24826 T24824 pobj bands,of
R19817 T24827 T24828 auxpass were,expressed
R19818 T24828 T24828 ROOT expressed,expressed
R19819 T24829 T24830 mark as,fold
R19820 T24830 T24828 advcl fold,expressed
R19821 T24831 T24830 dobj increase,fold
R19822 T24832 T24831 prep above,increase
R19823 T24833 T24834 det the,control
R19824 T24834 T24832 pobj control,above
R19825 T24835 T24834 punct (,control
R19826 T24836 T24834 appos lane,control
R19827 T24837 T24836 nummod 1,lane
R19828 T24838 T24834 punct ),control
R19829 T24839 T24828 punct .,expressed
R19830 T24840 T24846 punct (,measured
R19831 T24841 T24844 nmod C,activity
R19832 T24842 T24841 punct ),C
R19833 T24843 T24844 compound IKK,activity
R19834 T24844 T24846 nsubjpass activity,measured
R19835 T24845 T24846 auxpass was,measured
R19836 T24846 T24846 ROOT measured,measured
R19837 T24847 T24846 prep in,measured
R19838 T24848 T24849 amod cytosolic,extracts
R19839 T24849 T24847 pobj extracts,in
R19840 T24850 T24849 punct (,extracts
R19841 T24851 T24852 nummod 100,µg
R19842 T24852 T24849 appos µg,extracts
R19843 T24853 T24849 punct ),extracts
R19844 T24854 T24846 prep by,measured
R19845 T24855 T24854 pcomp using,by
R19846 T24856 T24859 nmod HTScan,assay
R19847 T24857 T24859 nmod IKK,assay
R19848 T24858 T24859 compound kinase,assay
R19849 T24859 T24855 dobj assay,using
R19850 T24860 T24859 punct (,assay
R19851 T24861 T24863 compound Cell,Technology
R19852 T24862 T24863 compound Signaling,Technology
R19853 T24863 T24859 appos Technology,assay
R19854 T24864 T24859 punct ),assay
R19855 T24865 T24846 punct .,measured
R19856 T24866 T24877 punct (,transfected
R19857 T24867 T24870 compound D,cells
R19858 T24868 T24869 punct ),HeLa
R19859 T24869 T24870 compound HeLa,cells
R19860 T24870 T24877 nsubjpass cells,transfected
R19861 T24871 T24870 punct (,cells
R19862 T24872 T24874 nummod 5,106
R19863 T24873 T24874 nummod ×,106
R19864 T24874 T24870 appos 106,cells
R19865 T24875 T24870 punct ),cells
R19866 T24876 T24877 auxpass were,transfected
R19867 T24877 T24893 ccomp transfected,stimulated
R19868 T24878 T24877 prep with,transfected
R19869 T24879 T24878 cc or,with
R19870 T24880 T24878 conj without,with
R19871 T24881 T24880 pobj p3xFLAG-Tat,without
R19872 T24882 T24881 punct (,p3xFLAG-Tat
R19873 T24883 T24884 nummod 5,µg
R19874 T24884 T24881 appos µg,p3xFLAG-Tat
R19875 T24885 T24881 punct ),p3xFLAG-Tat
R19876 T24886 T24893 punct ;,stimulated
R19877 T24887 T24888 nummod 48,h
R19878 T24888 T24889 npadvmod h,later
R19879 T24889 T24893 advmod later,stimulated
R19880 T24890 T24893 punct ",",stimulated
R19881 T24891 T24893 nsubjpass cells,stimulated
R19882 T24892 T24893 auxpass were,stimulated
R19883 T24893 T24893 ROOT stimulated,stimulated
R19884 T24894 T24893 prep with,stimulated
R19885 T24895 T24894 pobj PMA,with
R19886 T24896 T24895 punct (,PMA
R19887 T24897 T24898 nummod 5,min
R19888 T24898 T24895 appos min,PMA
R19889 T24899 T24898 punct ",",min
R19890 T24900 T24901 nummod 20,ng/ml
R19891 T24901 T24898 appos ng/ml,min
R19892 T24902 T24898 punct ),min
R19893 T24903 T24898 cc or,min
R19894 T24904 T24893 conj left,stimulated
R19895 T24905 T24904 oprd unstimulated,left
R19896 T24906 T24907 punct ",",washed
R19897 T24907 T24893 conj washed,stimulated
R19898 T24908 T24907 advmod twice,washed
R19899 T24909 T24907 prep with,washed
R19900 T24910 T24909 pobj DMEM,with
R19901 T24911 T24907 punct ",",washed
R19902 T24912 T24907 cc and,washed
R19903 T24913 T24907 conj harvested,washed
R19904 T24914 T24913 prep after,harvested
R19905 T24915 T24916 nummod 240,min
R19906 T24916 T24914 pobj min,after
R19907 T24917 T24893 punct .,stimulated
R19908 T24918 T24920 amod Whole,extracts
R19909 T24919 T24920 compound cell,extracts
R19910 T24920 T24926 nsubjpass extracts,immunoprecipitated
R19911 T24921 T24923 punct (,mg
R19912 T24922 T24923 nummod 1,mg
R19913 T24923 T24920 appos mg,extracts
R19914 T24924 T24920 punct ),extracts
R19915 T24925 T24926 auxpass were,immunoprecipitated
R19916 T24926 T24926 ROOT immunoprecipitated,immunoprecipitated
R19917 T24927 T24926 prep with,immunoprecipitated
R19918 T24928 T24931 nmod protein,antibody
R19919 T24929 T24931 amod G-Sepharose-coupled,antibody
R19920 T24930 T24931 amod anti-IκB-α,antibody
R19921 T24931 T24927 pobj antibody,with
R19922 T24932 T24926 punct .,immunoprecipitated
R19923 T24933 T24935 nsubjpass Immunocomplexes,separated
R19924 T24934 T24935 auxpass were,separated
R19925 T24935 T24935 ROOT separated,separated
R19926 T24936 T24935 prep by,separated
R19927 T24937 T24938 nummod 12,%
R19928 T24938 T24939 compound %,SDS
R19929 T24939 T24936 pobj SDS,by
R19930 T24940 T24939 conj PAGE,SDS
R19931 T24941 T24935 cc and,separated
R19932 T24942 T24935 conj analysed,separated
R19933 T24943 T24942 agent by,analysed
R19934 T24944 T24945 amod western,blotting
R19935 T24945 T24943 pobj blotting,by
R19936 T24946 T24945 prep with,blotting
R19937 T24947 T24952 amod anti-p65,antibodies
R19938 T24948 T24947 punct ",",anti-p65
R19939 T24949 T24947 conj anti-FLAG,anti-p65
R19940 T24950 T24949 cc and,anti-FLAG
R19941 T24951 T24949 conj anti-IκB-α,anti-FLAG
R19942 T24952 T24946 pobj antibodies,with
R19943 T24953 T24935 punct .,separated
R19944 T24954 T24955 compound Densitometry,values
R19945 T24955 T24963 nsubjpass values,expressed
R19946 T24956 T24957 punct (,D
R19947 T24957 T24955 appos D,values
R19948 T24958 T24957 punct ),D
R19949 T24959 T24957 prep of,D
R19950 T24960 T24961 det the,bands
R19951 T24961 T24959 pobj bands,of
R19952 T24962 T24963 auxpass were,expressed
R19953 T24963 T24963 ROOT expressed,expressed
R19954 T24964 T24963 prep as,expressed
R19955 T24965 T24966 compound fold,increase
R19956 T24966 T24964 pobj increase,as
R19957 T24967 T24966 prep above,increase
R19958 T24968 T24969 det the,control
R19959 T24969 T24967 pobj control,above
R19960 T24970 T24969 punct (,control
R19961 T24971 T24969 appos lane,control
R19962 T24972 T24971 nummod 1,lane
R19963 T24973 T24969 punct ),control
R19964 T24974 T24963 punct .,expressed
R19965 T24975 T24986 nsubjpass Values,shown
R19966 T24976 T24975 punct (,Values
R19967 T24977 T24979 amod mean,SE
R19968 T24978 T24979 compound ±,SE
R19969 T24979 T24975 appos SE,Values
R19970 T24980 T24986 punct ",",shown
R19971 T24981 T24986 nsubjpass n,shown
R19972 T24982 T24983 punct =,3
R19973 T24983 T24981 nummod 3,n
R19974 T24984 T24986 punct ),shown
R19975 T24985 T24986 auxpass are,shown
R19976 T24986 T24986 ROOT shown,shown
R19977 T24987 T24986 punct .,shown
R20432 T25677 T25678 nsubj Tat,relieves
R20433 T25678 T25678 ROOT relieves,relieves
R20434 T25679 T25678 dobj p65,relieves
R20435 T25680 T25678 prep from,relieves
R20436 T25681 T25683 det the,inhibition
R20437 T25682 T25683 amod IκB-α,inhibition
R20438 T25683 T25680 pobj inhibition,from
R20439 T25684 T25678 punct .,relieves
R20440 T25685 T25686 punct (,A
R20441 T25686 T25689 nmod A,representation
R20442 T25687 T25686 punct ),A
R20443 T25688 T25689 amod Schematic,representation
R20444 T25689 T25689 ROOT representation,representation
R20445 T25690 T25689 prep of,representation
R20446 T25691 T25695 amod wild-type,proteins
R20447 T25692 T25691 cc and,wild-type
R20448 T25693 T25691 conj mutant,wild-type
R20449 T25694 T25695 compound Tat,proteins
R20450 T25695 T25690 pobj proteins,of
R20451 T25696 T25689 punct .,representation
R20452 T25697 T25700 punct (,HA-IκB-α
R20453 T25698 T25700 nmod B,HA-IκB-α
R20454 T25699 T25700 punct ),HA-IκB-α
R20455 T25700 T25706 nsubjpass HA-IκB-α,incubated
R20456 T25701 T25703 punct (,µl
R20457 T25702 T25703 nummod 5,µl
R20458 T25703 T25700 appos µl,HA-IκB-α
R20459 T25704 T25703 punct ),µl
R20460 T25705 T25706 auxpass was,incubated
R20461 T25706 T25706 ROOT incubated,incubated
R20462 T25707 T25706 prep in,incubated
R20463 T25708 T25707 pobj presence,in
R20464 T25709 T25708 cc or,presence
R20465 T25710 T25708 conj absence,presence
R20466 T25711 T25710 prep of,absence
R20467 T25712 T25711 pobj FLAG-Tat,of
R20468 T25713 T25712 punct ",",FLAG-Tat
R20469 T25714 T25715 compound FLAG-Tat,T
R20470 T25715 T25712 conj T,FLAG-Tat
R20471 T25716 T25715 punct ",",T
R20472 T25717 T25767 punct ;,separated
R20473 T25718 T25715 conj N,T
R20474 T25719 T25720 punct (,"23,24"
R20475 T25720 T25718 parataxis "23,24",N
R20476 T25721 T25720 punct ),"23,24"
R20477 T25722 T25725 det A,K
R20478 T25723 T25725 punct ",",K
R20479 T25724 T25725 compound FLAG-Tat,K
R20480 T25725 T25725 ROOT K,K
R20481 T25726 T25725 punct (,K
R20482 T25727 T25725 appos "50,51",K
R20483 T25728 T25725 punct ),K
R20484 T25729 T25732 det A,R
R20485 T25730 T25732 punct ",",R
R20486 T25731 T25732 amod FLAG-Tat,R
R20487 T25732 T25732 ROOT R,R
R20488 T25733 T25732 punct (,R
R20489 T25734 T25732 appos 49,R
R20490 T25735 T25732 appos 57,R
R20491 T25736 T25732 punct ),R
R20492 T25737 T25740 det A,C
R20493 T25738 T25739 cc or,FLAG-Tat
R20494 T25739 T25740 compound FLAG-Tat,C
R20495 T25740 T25740 ROOT C,C
R20496 T25741 T25740 punct (,C
R20497 T25742 T25740 appos "22,25,27",C
R20498 T25743 T25740 punct ),C
R20499 T25744 T25747 det A,µl
R20500 T25745 T25747 punct (,µl
R20501 T25746 T25747 nummod 10,µl
R20502 T25747 T25747 ROOT µl,µl
R20503 T25748 T25747 punct ),µl
R20504 T25749 T25747 acl using,µl
R20505 T25750 T25749 prep in,using
R20506 T25751 T25753 amod vitro,proteins
R20507 T25752 T25753 amod translated,proteins
R20508 T25753 T25750 pobj proteins,in
R20509 T25754 T25747 punct .,µl
R20510 T25755 T25759 amod Wild-type,proteins
R20511 T25756 T25755 cc and,Wild-type
R20512 T25757 T25755 conj mutant,Wild-type
R20513 T25758 T25759 compound Tat,proteins
R20514 T25759 T25761 nsubjpass proteins,immunoprecipitated
R20515 T25760 T25761 auxpass were,immunoprecipitated
R20516 T25761 T25767 ccomp immunoprecipitated,separated
R20517 T25762 T25761 prep with,immunoprecipitated
R20518 T25763 T25764 amod anti-FLAG,antibody
R20519 T25764 T25762 pobj antibody,with
R20520 T25765 T25767 nsubjpass immunocomplexes,separated
R20521 T25766 T25767 auxpass were,separated
R20522 T25767 T25767 ROOT separated,separated
R20523 T25768 T25767 prep by,separated
R20524 T25769 T25770 nummod 12,%
R20525 T25770 T25768 pobj %,by
R20526 T25771 T25772 compound SDS,PAGE
R20527 T25772 T25767 dobj PAGE,separated
R20528 T25773 T25772 cc and,PAGE
R20529 T25774 T25772 conj analysed,PAGE
R20530 T25775 T25774 agent by,analysed
R20531 T25776 T25777 amod western,blotting
R20532 T25777 T25775 pobj blotting,by
R20533 T25778 T25777 prep with,blotting
R20534 T25779 T25782 amod anti-HA,antibodies
R20535 T25780 T25779 cc and,anti-HA
R20536 T25781 T25779 conj anti-FLAG,anti-HA
R20537 T25782 T25778 pobj antibodies,with
R20538 T25783 T25767 punct .,separated
R20539 T25784 T25785 punct (,C
R20540 T25785 T25788 nmod C,p65
R20541 T25786 T25785 punct ),C
R20542 T25787 T25788 amod 35S-methionine-labeled,p65
R20543 T25788 T25794 nsubjpass p65,incubated
R20544 T25789 T25788 punct (,p65
R20545 T25790 T25791 nummod 5,µl
R20546 T25791 T25788 appos µl,p65
R20547 T25792 T25791 punct ),µl
R20548 T25793 T25794 auxpass was,incubated
R20549 T25794 T25794 ROOT incubated,incubated
R20550 T25795 T25794 prep with,incubated
R20551 T25796 T25798 prep in,translated
R20552 T25797 T25798 nsubj vitro,translated
R20553 T25798 T25794 conj translated,incubated
R20554 T25799 T25798 dobj HA-IκB-α,translated
R20555 T25800 T25802 punct (,µl
R20556 T25801 T25802 nummod 5,µl
R20557 T25802 T25799 appos µl,HA-IκB-α
R20558 T25803 T25802 punct ),µl
R20559 T25804 T25798 prep in,translated
R20560 T25805 T25804 pobj presence,in
R20561 T25806 T25805 cc or,presence
R20562 T25807 T25805 conj absence,presence
R20563 T25808 T25807 prep of,absence
R20564 T25809 T25808 pobj FLAG-Tat,of
R20565 T25810 T25809 cc or,FLAG-Tat
R20566 T25811 T25812 compound FLAG-Tat,R
R20567 T25812 T25809 conj R,FLAG-Tat
R20568 T25813 T25809 punct (,FLAG-Tat
R20569 T25814 T25809 appos 49,FLAG-Tat
R20570 T25815 T25809 appos 57,FLAG-Tat
R20571 T25816 T25809 punct ),FLAG-Tat
R20572 T25817 T25824 det A,µl
R20573 T25818 T25824 punct (,µl
R20574 T25819 T25824 nummod 5,µl
R20575 T25820 T25824 punct ",",µl
R20576 T25821 T25824 nummod 10,µl
R20577 T25822 T25821 cc or,10
R20578 T25823 T25821 conj 20,10
R20579 T25824 T25824 ROOT µl,µl
R20580 T25825 T25824 punct ),µl
R20581 T25826 T25824 punct .,µl
R20582 T25827 T25829 nsubjpass HA-IκB-α,immunoprecipitated
R20583 T25828 T25829 auxpass was,immunoprecipitated
R20584 T25829 T25836 ccomp immunoprecipitated,separated
R20585 T25830 T25829 prep with,immunoprecipitated
R20586 T25831 T25832 amod anti-HA,antibody
R20587 T25832 T25830 pobj antibody,with
R20588 T25833 T25836 punct ;,separated
R20589 T25834 T25836 nsubjpass immunocomplexes,separated
R20590 T25835 T25836 auxpass were,separated
R20591 T25836 T25836 ROOT separated,separated
R20592 T25837 T25836 prep by,separated
R20593 T25838 T25839 nummod 12,%
R20594 T25839 T25840 compound %,SDS
R20595 T25840 T25837 pobj SDS,by
R20596 T25841 T25840 conj PAGE,SDS
R20597 T25842 T25836 cc and,separated
R20598 T25843 T25836 conj analysed,separated
R20599 T25844 T25843 agent by,analysed
R20600 T25845 T25846 amod western,blotting
R20601 T25846 T25844 pobj blotting,by
R20602 T25847 T25846 prep with,blotting
R20603 T25848 T25851 amod anti-HA,antibodies
R20604 T25849 T25848 cc and,anti-HA
R20605 T25850 T25848 conj anti-FLAG,anti-HA
R20606 T25851 T25847 pobj antibodies,with
R20607 T25852 T25851 punct ",",antibodies
R20608 T25853 T25851 cc or,antibodies
R20609 T25854 T25851 conj autoradiography,antibodies
R20610 T25855 T25856 punct (,35S-Met-p65
R20611 T25856 T25854 appos 35S-Met-p65,autoradiography
R20612 T25857 T25843 punct ),analysed
R20613 T25858 T25836 punct .,separated
R20614 T25859 T25860 compound Densitometry,values
R20615 T25860 T25868 nsubjpass values,expressed
R20616 T25861 T25862 punct (,D
R20617 T25862 T25860 appos D,values
R20618 T25863 T25860 punct ),values
R20619 T25864 T25860 prep of,values
R20620 T25865 T25866 det the,bands
R20621 T25866 T25864 pobj bands,of
R20622 T25867 T25868 auxpass were,expressed
R20623 T25868 T25868 ROOT expressed,expressed
R20624 T25869 T25870 mark as,fold
R20625 T25870 T25868 advcl fold,expressed
R20626 T25871 T25870 dobj increase,fold
R20627 T25872 T25870 prep above,fold
R20628 T25873 T25874 det the,control
R20629 T25874 T25872 pobj control,above
R20630 T25875 T25874 punct (,control
R20631 T25876 T25874 appos lane,control
R20632 T25877 T25876 nummod 1,lane
R20633 T25878 T25874 punct ),control
R20634 T25879 T25868 punct .,expressed
R20635 T25880 T25881 punct (,D
R20636 T25881 T25881 ROOT D,D
R20637 T25882 T25881 punct ),D
R20638 T25883 T25885 det The,DNA
R20639 T25884 T25885 nummod p65,DNA
R20640 T25885 T25887 compound DNA,activity
R20641 T25886 T25887 amod binding,activity
R20642 T25887 T25889 nsubjpass activity,analysed
R20643 T25888 T25889 auxpass was,analysed
R20644 T25889 T25889 ROOT analysed,analysed
R20645 T25890 T25889 agent by,analysed
R20646 T25891 T25890 pobj EMSA,by
R20647 T25892 T25889 advcl using,analysed
R20648 T25893 T25892 prt in,using
R20649 T25894 T25896 amod vitro,proteins
R20650 T25895 T25896 amod translated,proteins
R20651 T25896 T25893 pobj proteins,in
R20652 T25897 T25889 punct .,analysed
R20653 T25898 T25900 amod 32P-labeled-NF-κB,oligonucleotide
R20654 T25899 T25900 amod double-stranded,oligonucleotide
R20655 T25900 T25902 nsubjpass oligonucleotide,incubated
R20656 T25901 T25902 auxpass was,incubated
R20657 T25902 T25902 ROOT incubated,incubated
R20658 T25903 T25902 prep with,incubated
R20659 T25904 T25903 pobj p65,with
R20660 T25905 T25907 punct (,µl
R20661 T25906 T25907 nummod 0.5,µl
R20662 T25907 T25904 appos µl,p65
R20663 T25908 T25907 punct ),µl
R20664 T25909 T25907 prep in,µl
R20665 T25910 T25909 pobj presence,in
R20666 T25911 T25910 cc or,presence
R20667 T25912 T25910 conj absence,presence
R20668 T25913 T25912 prep of,absence
R20669 T25914 T25923 nmod HA-IκB-α,R
R20670 T25915 T25917 punct (,µl
R20671 T25916 T25917 nummod 1,µl
R20672 T25917 T25914 appos µl,HA-IκB-α
R20673 T25918 T25917 punct ),µl
R20674 T25919 T25917 punct ",",µl
R20675 T25920 T25923 amod FLAG-Tat,R
R20676 T25921 T25920 cc or,FLAG-Tat
R20677 T25922 T25920 conj FLAG-Tat,FLAG-Tat
R20678 T25923 T25913 pobj R,of
R20679 T25924 T25923 punct (,R
R20680 T25925 T25923 appos 49,R
R20681 T25926 T25923 appos 57,R
R20682 T25927 T25923 punct ),R
R20683 T25928 T25933 det A,µl
R20684 T25929 T25930 punct (,5
R20685 T25930 T25933 nummod 5,µl
R20686 T25931 T25930 cc and,5
R20687 T25932 T25930 conj 10,5
R20688 T25933 T25941 nsubjpass µl,performed
R20689 T25934 T25933 punct ),µl
R20690 T25935 T25936 punct ;,competition
R20691 T25936 T25941 nsubjpass competition,performed
R20692 T25937 T25936 prep of,competition
R20693 T25938 T25937 pobj DNA,of
R20694 T25939 T25941 nsubjpass binding,performed
R20695 T25940 T25941 auxpass was,performed
R20696 T25941 T25941 ROOT performed,performed
R20697 T25942 T25941 prep with,performed
R20698 T25943 T25949 nummod 10,excess
R20699 T25944 T25945 punct -,up
R20700 T25945 T25949 nmod up,excess
R20701 T25946 T25947 quantmod to,100-fold
R20702 T25947 T25949 nmod 100-fold,excess
R20703 T25948 T25949 compound molar,excess
R20704 T25949 T25942 pobj excess,with
R20705 T25950 T25949 prep of,excess
R20706 T25951 T25954 amod unlabeled,oligonucleotide
R20707 T25952 T25954 amod NF-κB,oligonucleotide
R20708 T25953 T25954 amod double-stranded,oligonucleotide
R20709 T25954 T25950 pobj oligonucleotide,of
R20710 T25955 T25941 punct .,performed
R20711 T25956 T25957 compound DNA/protein,complexes
R20712 T25957 T25959 nsubjpass complexes,run
R20713 T25958 T25959 auxpass were,run
R20714 T25959 T25959 ROOT run,run
R20715 T25960 T25959 prep on,run
R20716 T25961 T25962 nummod 6,%
R20717 T25962 T25963 compound %,PAGE
R20718 T25963 T25960 pobj PAGE,on
R20719 T25964 T25963 appos TBE,PAGE
R20720 T25965 T25959 cc and,run
R20721 T25966 T25959 conj analysed,run
R20722 T25967 T25966 agent by,analysed
R20723 T25968 T25967 pobj autoradiography,by
R20724 T25969 T25959 punct .,run
R20725 T25970 T25989 punct (,transfected
R20726 T25971 T25980 dep E,−
R20727 T25972 T25973 punct ),p50
R20728 T25973 T25980 dep p50,−
R20729 T25974 T25980 dep −,−
R20730 T25975 T25980 dep /,−
R20731 T25976 T25980 dep −,−
R20732 T25977 T25980 dep p65,−
R20733 T25978 T25980 dep −,−
R20734 T25979 T25980 dep /,−
R20735 T25980 T25981 nmod −,MEFs
R20736 T25981 T25989 nsubjpass MEFs,transfected
R20737 T25982 T25981 punct (,MEFs
R20738 T25983 T25986 nummod 3,cells
R20739 T25984 T25986 nummod ×,cells
R20740 T25985 T25986 nummod 105,cells
R20741 T25986 T25981 appos cells,MEFs
R20742 T25987 T25981 punct ),MEFs
R20743 T25988 T25989 auxpass were,transfected
R20744 T25989 T25989 ROOT transfected,transfected
R20745 T25990 T25989 prep with,transfected
R20746 T25991 T25990 pobj pκBLuc,with
R20747 T25992 T25994 punct (,µg
R20748 T25993 T25994 nummod 0.5,µg
R20749 T25994 T25991 appos µg,pκBLuc
R20750 T25995 T25994 punct ),µg
R20751 T25996 T25991 cc and,pκBLuc
R20752 T25997 T25991 conj pSV-β-Gal,pκBLuc
R20753 T25998 T26000 punct (,µg
R20754 T25999 T26000 nummod 0.1,µg
R20755 T26000 T25997 appos µg,pSV-β-Gal
R20756 T26001 T26000 punct ),µg
R20757 T26002 T25997 prep with,pSV-β-Gal
R20758 T26003 T26002 cc or,with
R20759 T26004 T26002 conj without,with
R20760 T26005 T26004 pobj pRc/CMV-p,without
R20761 T26006 T26005 nummod 65,pRc/CMV-p
R20762 T26007 T26009 punct (,µg
R20763 T26008 T26009 nummod 0.5,µg
R20764 T26009 T26005 appos µg,pRc/CMV-p
R20765 T26010 T26009 punct ),µg
R20766 T26011 T26005 punct ",",pRc/CMV-p
R20767 T26012 T26005 appos pCMV4-HA-IκB-α,pRc/CMV-p
R20768 T26013 T26015 punct (,µg
R20769 T26014 T26015 nummod 0.5,µg
R20770 T26015 T26012 appos µg,pCMV4-HA-IκB-α
R20771 T26016 T26015 punct ),µg
R20772 T26017 T26015 punct ",",µg
R20773 T26018 T26015 conj p3xFLAG-Tat,µg
R20774 T26019 T26018 cc or,p3xFLAG-Tat
R20775 T26020 T26018 conj p3xFLAG-Tat,p3xFLAG-Tat
R20776 T26021 T26004 pobj R,without
R20777 T26022 T26024 punct (,57
R20778 T26023 T26024 nummod 49,57
R20779 T26024 T26021 appos 57,R
R20780 T26025 T26021 punct ),R
R20781 T26026 T26033 det A,µg
R20782 T26027 T26033 punct (,µg
R20783 T26028 T26033 nummod 0.5,µg
R20784 T26029 T26030 punct ",",1
R20785 T26030 T26028 prep 1,0.5
R20786 T26031 T26028 cc and,0.5
R20787 T26032 T26028 conj 2,0.5
R20788 T26033 T26033 ROOT µg,µg
R20789 T26034 T26033 punct ),µg
R20790 T26035 T26033 punct .,µg
R20791 T26036 T26038 det The,activity
R20792 T26037 T26038 compound luciferase,activity
R20793 T26038 T26040 nsubjpass activity,measured
R20794 T26039 T26040 auxpass was,measured
R20795 T26040 T26040 ROOT measured,measured
R20796 T26041 T26040 prep in,measured
R20797 T26042 T26043 compound cell,extracts
R20798 T26043 T26041 pobj extracts,in
R20799 T26044 T26045 compound 48-h,post-transfection
R20800 T26045 T26043 appos post-transfection,extracts
R20801 T26046 T26045 cc and,post-transfection
R20802 T26047 T26045 conj normalized,post-transfection
R20803 T26048 T26047 prep to,normalized
R20804 T26049 T26050 amod β-galactosidase,activity
R20805 T26050 T26048 pobj activity,to
R20806 T26051 T26040 punct .,measured
R20807 T26052 T26053 compound Fold,activation
R20808 T26053 T26055 nsubjpass activation,calculated
R20809 T26054 T26055 auxpass was,calculated
R20810 T26055 T26055 ROOT calculated,calculated
R20811 T26056 T26055 oprd relative,calculated
R20812 T26057 T26056 prep to,relative
R20813 T26058 T26057 pobj transfection,to
R20814 T26059 T26058 prep of,transfection
R20815 T26060 T26062 det the,plasmid
R20816 T26061 T26062 compound pκBLuc,plasmid
R20817 T26062 T26059 pobj plasmid,of
R20818 T26063 T26058 advmod alone,transfection
R20819 T26064 T26055 punct .,calculated
R20820 T26065 T26076 nsubjpass Values,shown
R20821 T26066 T26069 punct (,SE
R20822 T26067 T26069 amod mean,SE
R20823 T26068 T26069 compound ±,SE
R20824 T26069 T26065 appos SE,Values
R20825 T26070 T26069 punct ",",SE
R20826 T26071 T26073 nmod n,3
R20827 T26072 T26073 punct =,3
R20828 T26073 T26069 appos 3,SE
R20829 T26074 T26069 punct ),SE
R20830 T26075 T26076 auxpass are,shown
R20831 T26076 T26076 ROOT shown,shown
R20832 T26077 T26076 punct .,shown
R20833 T26078 T26093 prep As,analysed
R20834 T26079 T26078 pobj control,As
R20835 T26080 T26079 prep of,control
R20836 T26081 T26082 compound protein,expression
R20837 T26082 T26080 pobj expression,of
R20838 T26083 T26093 punct ",",analysed
R20839 T26084 T26093 nsubjpass aliquots,analysed
R20840 T26085 T26084 prep of,aliquots
R20841 T26086 T26087 compound cell,extracts
R20842 T26087 T26085 pobj extracts,of
R20843 T26088 T26087 punct (,extracts
R20844 T26089 T26090 nummod 20,µg
R20845 T26090 T26087 appos µg,extracts
R20846 T26091 T26087 punct ),extracts
R20847 T26092 T26093 auxpass were,analysed
R20848 T26093 T26093 ROOT analysed,analysed
R20849 T26094 T26093 agent by,analysed
R20850 T26095 T26096 amod western,blotting
R20851 T26096 T26094 pobj blotting,by
R20852 T26097 T26096 prep with,blotting
R20853 T26098 T26105 amod anti-p65,antibodies
R20854 T26099 T26098 punct ",",anti-p65
R20855 T26100 T26105 amod anti-HA,antibodies
R20856 T26101 T26100 punct ",",anti-HA
R20857 T26102 T26100 conj anti-FLAG,anti-HA
R20858 T26103 T26102 cc and,anti-FLAG
R20859 T26104 T26102 conj anti-γ-tubulin,anti-FLAG
R20860 T26105 T26097 pobj antibodies,with
R20861 T26106 T26093 punct .,analysed
R20925 T26585 T26586 compound Tat,associates
R20926 T26586 T26586 ROOT associates,associates
R20927 T26587 T26586 prep with,associates
R20928 T26588 T26589 nsubj p65,increasing
R20929 T26589 T26587 pcomp increasing,with
R20930 T26590 T26592 poss its,binding
R20931 T26591 T26592 advmod DNA-affinity,binding
R20932 T26592 T26589 dobj binding,increasing
R20933 T26593 T26586 punct .,associates
R20934 T26594 T26600 punct (,transfected
R20935 T26595 T26598 nmod A,cells
R20936 T26596 T26595 punct ),A
R20937 T26597 T26598 compound HeLa,cells
R20938 T26598 T26600 nsubjpass cells,transfected
R20939 T26599 T26600 auxpass were,transfected
R20940 T26600 T26600 ROOT transfected,transfected
R20941 T26601 T26600 prep with,transfected
R20942 T26602 T26601 pobj pRc/CMV,with
R20943 T26603 T26604 nummod -3,xHA-p65
R20944 T26604 T26600 npadvmod xHA-p65,transfected
R20945 T26605 T26607 punct (,µg
R20946 T26606 T26607 nummod 5,µg
R20947 T26607 T26604 appos µg,xHA-p65
R20948 T26608 T26607 punct ),µg
R20949 T26609 T26604 prep in,xHA-p65
R20950 T26610 T26609 pobj presence,in
R20951 T26611 T26610 cc or,presence
R20952 T26612 T26610 conj absence,presence
R20953 T26613 T26612 prep of,absence
R20954 T26614 T26613 pobj p3xFLAG-Tat,of
R20955 T26615 T26612 punct ",",absence
R20956 T26616 T26617 compound p3xFLAG-Tat,T
R20957 T26617 T26604 conj T,xHA-p65
R20958 T26618 T26617 punct ",",T
R20959 T26619 T26617 conj N,T
R20960 T26620 T26621 punct (,"23,24"
R20961 T26621 T26619 parataxis "23,24",N
R20962 T26622 T26621 punct ),"23,24"
R20963 T26623 T26626 det A,K
R20964 T26624 T26626 punct ",",K
R20965 T26625 T26626 compound p3xFLAG-Tat,K
R20966 T26626 T26604 npadvmod K,xHA-p65
R20967 T26627 T26626 punct (,K
R20968 T26628 T26626 appos "50,51",K
R20969 T26629 T26626 punct ),K
R20970 T26630 T26633 det A,R
R20971 T26631 T26633 punct ",",R
R20972 T26632 T26633 amod p3xFLAG-Tat,R
R20973 T26633 T26633 ROOT R,R
R20974 T26634 T26633 punct (,R
R20975 T26635 T26633 appos 49,R
R20976 T26636 T26633 appos 57,R
R20977 T26637 T26633 punct ),R
R20978 T26638 T26638 ROOT A,A
R20979 T26639 T26638 punct ",",A
R20980 T26640 T26638 cc or,A
R20981 T26641 T26642 compound p3xFLAG-Tat,C
R20982 T26642 T26638 conj C,A
R20983 T26643 T26642 punct (,C
R20984 T26644 T26642 appos "22,25,27",C
R20985 T26645 T26642 punct ),C
R20986 T26646 T26649 det A,µg
R20987 T26647 T26649 punct (,µg
R20988 T26648 T26649 nummod 5,µg
R20989 T26649 T26649 ROOT µg,µg
R20990 T26650 T26649 punct ),µg
R20991 T26651 T26649 punct .,µg
R20992 T26652 T26653 amod FLAG-Tat,proteins
R20993 T26653 T26655 nsubjpass proteins,immunoprecipitated
R20994 T26654 T26655 auxpass were,immunoprecipitated
R20995 T26655 T26662 ccomp immunoprecipitated,separated
R20996 T26656 T26655 prep with,immunoprecipitated
R20997 T26657 T26658 amod anti-FLAG,antibody
R20998 T26658 T26656 pobj antibody,with
R20999 T26659 T26662 punct ;,separated
R21000 T26660 T26662 nsubjpass immunocomplexes,separated
R21001 T26661 T26662 auxpass were,separated
R21002 T26662 T26662 ROOT separated,separated
R21003 T26663 T26662 prep by,separated
R21004 T26664 T26665 nummod 12,%
R21005 T26665 T26666 compound %,SDS
R21006 T26666 T26663 pobj SDS,by
R21007 T26667 T26666 conj PAGE,SDS
R21008 T26668 T26662 cc and,separated
R21009 T26669 T26662 conj analysed,separated
R21010 T26670 T26669 agent by,analysed
R21011 T26671 T26672 amod western,blotting
R21012 T26672 T26670 pobj blotting,by
R21013 T26673 T26672 prep with,blotting
R21014 T26674 T26677 amod anti-FLAG,antibodies
R21015 T26675 T26674 cc or,anti-FLAG
R21016 T26676 T26674 conj anti-HA,anti-FLAG
R21017 T26677 T26673 pobj antibodies,with
R21018 T26678 T26662 punct .,separated
R21019 T26679 T26680 punct (,B
R21020 T26680 T26680 ROOT B,B
R21021 T26681 T26680 punct ),B
R21022 T26682 T26691 prep In,incubated
R21023 T26683 T26685 amod vitro,p65
R21024 T26684 T26685 amod translated,p65
R21025 T26685 T26682 pobj p65,In
R21026 T26686 T26685 punct (,p65
R21027 T26687 T26688 nummod 5,µl
R21028 T26688 T26685 appos µl,p65
R21029 T26689 T26688 punct ),µl
R21030 T26690 T26691 auxpass was,incubated
R21031 T26691 T26691 ROOT incubated,incubated
R21032 T26692 T26691 prep with,incubated
R21033 T26693 T26692 pobj GST-Tat,with
R21034 T26694 T26693 punct ",",GST-Tat
R21035 T26695 T26696 compound GST-Tat,T
R21036 T26696 T26693 conj T,GST-Tat
R21037 T26697 T26696 punct ",",T
R21038 T26698 T26696 conj N,T
R21039 T26699 T26700 punct (,"23,24"
R21040 T26700 T26698 parataxis "23,24",N
R21041 T26701 T26700 punct ),"23,24"
R21042 T26702 T26705 det A,K
R21043 T26703 T26705 punct ",",K
R21044 T26704 T26705 compound GST-Tat,K
R21045 T26705 T26705 ROOT K,K
R21046 T26706 T26705 punct (,K
R21047 T26707 T26705 appos "50,51",K
R21048 T26708 T26705 punct ),K
R21049 T26709 T26712 det A,R
R21050 T26710 T26712 punct ",",R
R21051 T26711 T26712 compound GST-Tat,R
R21052 T26712 T26712 ROOT R,R
R21053 T26713 T26712 punct (,R
R21054 T26714 T26712 appos 49,R
R21055 T26715 T26712 appos 57,R
R21056 T26716 T26712 punct ),R
R21057 T26717 T26720 det A,C
R21058 T26718 T26720 punct ",",C
R21059 T26719 T26720 compound GST-Tat,C
R21060 T26720 T26720 ROOT C,C
R21061 T26721 T26720 punct (,C
R21062 T26722 T26720 appos "22,25,27",C
R21063 T26723 T26720 punct ),C
R21064 T26724 T26724 ROOT A,A
R21065 T26725 T26724 punct ",",A
R21066 T26726 T26724 cc or,A
R21067 T26727 T26724 conj GST,A
R21068 T26728 T26730 punct (,µg
R21069 T26729 T26730 nummod 5,µg
R21070 T26730 T26727 appos µg,GST
R21071 T26731 T26730 punct ),µg
R21072 T26732 T26727 amod conjugated,GST
R21073 T26733 T26732 prep with,conjugated
R21074 T26734 T26733 pobj Glutathione-Sepharose,with
R21075 T26735 T26727 punct .,GST
R21076 T26736 T26737 compound Protein,complexes
R21077 T26737 T26739 nsubjpass complexes,recovered
R21078 T26738 T26739 auxpass were,recovered
R21079 T26739 T26739 ROOT recovered,recovered
R21080 T26740 T26739 agent by,recovered
R21081 T26741 T26740 pobj GST-pull,by
R21082 T26742 T26739 advmod down,recovered
R21083 T26743 T26739 punct ",",recovered
R21084 T26744 T26739 conj separated,recovered
R21085 T26745 T26744 prep by,separated
R21086 T26746 T26747 nummod 12,%
R21087 T26747 T26748 compound %,SDS
R21088 T26748 T26745 pobj SDS,by
R21089 T26749 T26748 conj PAGE,SDS
R21090 T26750 T26748 punct ",",SDS
R21091 T26751 T26744 cc and,separated
R21092 T26752 T26744 conj analysed,separated
R21093 T26753 T26752 agent by,analysed
R21094 T26754 T26755 amod western,blotting
R21095 T26755 T26753 pobj blotting,by
R21096 T26756 T26755 prep with,blotting
R21097 T26757 T26760 amod anti-p65,antibodies
R21098 T26758 T26757 cc or,anti-p65
R21099 T26759 T26757 conj anti-GST,anti-p65
R21100 T26760 T26756 pobj antibodies,with
R21101 T26761 T26739 punct .,recovered
R21102 T26762 T26763 punct (,C
R21103 T26763 T26766 nmod C,representation
R21104 T26764 T26763 punct ),C
R21105 T26765 T26766 amod Schematic,representation
R21106 T26766 T26766 ROOT representation,representation
R21107 T26767 T26766 prep of,representation
R21108 T26768 T26772 amod wild-type,proteins
R21109 T26769 T26768 cc and,wild-type
R21110 T26770 T26768 conj mutant,wild-type
R21111 T26771 T26772 compound p65,proteins
R21112 T26772 T26767 pobj proteins,of
R21113 T26773 T26766 punct .,representation
R21114 T26774 T26780 punct (,transfected
R21115 T26775 T26778 compound D,cells
R21116 T26776 T26777 punct ),HeLa
R21117 T26777 T26778 compound HeLa,cells
R21118 T26778 T26780 nsubjpass cells,transfected
R21119 T26779 T26780 auxpass were,transfected
R21120 T26780 T26780 ROOT transfected,transfected
R21121 T26781 T26780 prep with,transfected
R21122 T26782 T26781 pobj p3xFLAG-Tat,with
R21123 T26783 T26785 punct (,µg
R21124 T26784 T26785 nummod 5,µg
R21125 T26785 T26782 appos µg,p3xFLAG-Tat
R21126 T26786 T26785 punct ),µg
R21127 T26787 T26780 prep in,transfected
R21128 T26788 T26789 det the,presence
R21129 T26789 T26787 pobj presence,in
R21130 T26790 T26789 cc or,presence
R21131 T26791 T26789 conj absence,presence
R21132 T26792 T26791 prep of,absence
R21133 T26793 T26795 nmod pRc/CMV,xHA-p65
R21134 T26794 T26795 nummod -3,xHA-p65
R21135 T26795 T26792 pobj xHA-p65,of
R21136 T26796 T26795 punct ",",xHA-p65
R21137 T26797 T26799 nmod pRc/CMV,xHA-p65ΔC
R21138 T26798 T26799 nummod -3,xHA-p65ΔC
R21139 T26799 T26795 appos xHA-p65ΔC,xHA-p65
R21140 T26800 T26801 punct (,1
R21141 T26801 T26808 nummod 1,xHA-p65ΔN
R21142 T26802 T26801 appos 318,1
R21143 T26803 T26801 punct ),1
R21144 T26804 T26801 punct ",",1
R21145 T26805 T26801 cc or,1
R21146 T26806 T26808 nmod pRc/CMV,xHA-p65ΔN
R21147 T26807 T26808 nummod -3,xHA-p65ΔN
R21148 T26808 T26799 appos xHA-p65ΔN,xHA-p65ΔC
R21149 T26809 T26808 punct (,xHA-p65ΔN
R21150 T26810 T26811 dep 122,551
R21151 T26811 T26808 appos 551,xHA-p65ΔN
R21152 T26812 T26808 punct ),xHA-p65ΔN
R21153 T26813 T26815 punct (,µg
R21154 T26814 T26815 nummod 5,µg
R21155 T26815 T26808 appos µg,xHA-p65ΔN
R21156 T26816 T26815 punct ),µg
R21157 T26817 T26780 punct .,transfected
R21158 T26818 T26822 amod Wild-type,proteins
R21159 T26819 T26818 cc and,Wild-type
R21160 T26820 T26818 conj mutant,Wild-type
R21161 T26821 T26822 compound HA-p65,proteins
R21162 T26822 T26824 nsubjpass proteins,immunoprecipitated
R21163 T26823 T26824 auxpass were,immunoprecipitated
R21164 T26824 T26831 ccomp immunoprecipitated,separated
R21165 T26825 T26824 prep with,immunoprecipitated
R21166 T26826 T26827 amod anti-HA,antibody
R21167 T26827 T26825 pobj antibody,with
R21168 T26828 T26831 punct ;,separated
R21169 T26829 T26831 nsubjpass immunocomplexes,separated
R21170 T26830 T26831 auxpass were,separated
R21171 T26831 T26831 ROOT separated,separated
R21172 T26832 T26831 prep by,separated
R21173 T26833 T26834 nummod 12,%
R21174 T26834 T26832 pobj %,by
R21175 T26835 T26836 compound SDS,PAGE
R21176 T26836 T26831 npadvmod PAGE,separated
R21177 T26837 T26836 cc and,PAGE
R21178 T26838 T26836 conj analysed,PAGE
R21179 T26839 T26838 agent by,analysed
R21180 T26840 T26841 amod western,blotting
R21181 T26841 T26839 pobj blotting,by
R21182 T26842 T26841 prep with,blotting
R21183 T26843 T26846 amod anti-FLAG,antibodies
R21184 T26844 T26843 cc or,anti-FLAG
R21185 T26845 T26843 conj anti-HA,anti-FLAG
R21186 T26846 T26842 pobj antibodies,with
R21187 T26847 T26831 punct .,separated
R21188 T26848 T26866 punct (,was
R21189 T26849 T26853 nmod E,protein
R21190 T26850 T26849 punct ),E
R21191 T26851 T26852 amod Recombinant,p65
R21192 T26852 T26853 compound p65,protein
R21193 T26853 T26866 ccomp protein,was
R21194 T26854 T26856 punct (,ng
R21195 T26855 T26856 nummod 100,ng
R21196 T26856 T26853 appos ng,protein
R21197 T26857 T26866 punct ;,was
R21198 T26858 T26860 compound Active,Carlsbad
R21199 T26859 T26860 compound Motif,Carlsbad
R21200 T26860 T26866 nsubj Carlsbad,was
R21201 T26861 T26860 punct ",",Carlsbad
R21202 T26862 T26860 conj CA,Carlsbad
R21203 T26863 T26862 punct ",",CA
R21204 T26864 T26862 conj USA,CA
R21205 T26865 T26862 punct ),CA
R21206 T26866 T26866 ROOT was,was
R21207 T26867 T26868 nummod 20,min
R21208 T26868 T26866 attr min,was
R21209 T26869 T26868 acl incubated,min
R21210 T26870 T26869 prep with,incubated
R21211 T26871 T26874 amod 32P-labeled,oligonucleotide
R21212 T26872 T26874 amod NF-κB,oligonucleotide
R21213 T26873 T26874 amod double-stranded,oligonucleotide
R21214 T26874 T26870 pobj oligonucleotide,with
R21215 T26875 T26874 prep in,oligonucleotide
R21216 T26876 T26875 pobj presence,in
R21217 T26877 T26876 cc or,presence
R21218 T26878 T26876 conj absence,presence
R21219 T26879 T26876 prep of,presence
R21220 T26880 T26882 mark in,translated
R21221 T26881 T26882 nsubj vitro,translated
R21222 T26882 T26869 advcl translated,incubated
R21223 T26883 T26882 dobj FLAG-Tat,translated
R21224 T26884 T26883 cc or,FLAG-Tat
R21225 T26885 T26886 compound FLAG-Tat,C
R21226 T26886 T26883 conj C,FLAG-Tat
R21227 T26887 T26886 punct (,C
R21228 T26888 T26886 appos "22,25,27",C
R21229 T26889 T26886 punct ),C
R21230 T26890 T26893 det A,µl
R21231 T26891 T26893 punct (,µl
R21232 T26892 T26893 nummod 5,µl
R21233 T26893 T26893 ROOT µl,µl
R21234 T26894 T26893 punct ),µl
R21235 T26895 T26898 punct ;,performed
R21236 T26896 T26898 nsubjpass competitions,performed
R21237 T26897 T26898 auxpass were,performed
R21238 T26898 T26898 ROOT performed,performed
R21239 T26899 T26898 prep with,performed
R21240 T26900 T26906 nummod 1.25,excess
R21241 T26901 T26902 punct -,up
R21242 T26902 T26906 advmod up,excess
R21243 T26903 T26906 quantmod to,excess
R21244 T26904 T26903 pobj 40-fold,to
R21245 T26905 T26906 compound molar,excess
R21246 T26906 T26899 pobj excess,with
R21247 T26907 T26906 prep of,excess
R21248 T26908 T26909 amod unlabeled,oligonucleotide
R21249 T26909 T26907 pobj oligonucleotide,of
R21250 T26910 T26898 punct .,performed
R21251 T26911 T26912 compound DNA/protein,complexes
R21252 T26912 T26914 nsubjpass complexes,separated
R21253 T26913 T26914 auxpass were,separated
R21254 T26914 T26914 ROOT separated,separated
R21255 T26915 T26914 prep by,separated
R21256 T26916 T26917 nummod 6,%
R21257 T26917 T26918 compound %,PAGE
R21258 T26918 T26915 pobj PAGE,by
R21259 T26919 T26914 prep in,separated
R21260 T26920 T26923 nummod 0.5,buffer
R21261 T26921 T26923 nummod ×,buffer
R21262 T26922 T26923 compound TBE,buffer
R21263 T26923 T26919 pobj buffer,in
R21264 T26924 T26923 cc and,buffer
R21265 T26925 T26914 advcl analysed,separated
R21266 T26926 T26925 agent by,analysed
R21267 T26927 T26926 pobj autoradiography,by
R21268 T26928 T26914 punct .,separated
R21269 T26929 T26932 punct (,Densitometry
R21270 T26930 T26932 nmod F,Densitometry
R21271 T26931 T26932 punct ),Densitometry
R21272 T26932 T26932 ROOT Densitometry,Densitometry
R21273 T26933 T26932 prep of,Densitometry
R21274 T26934 T26933 pobj band-shifts,of
R21275 T26935 T26932 acl shown,Densitometry
R21276 T26936 T26935 prep in,shown
R21277 T26937 T26936 pobj E.,in
R21767 T27724 T27722 pobj PCR,by
R21768 T27725 T27726 aux to,evaluate
R21769 T27726 T27721 xcomp evaluate,analysed
R21770 T27727 T27728 det the,expression
R21771 T27728 T27726 dobj expression,evaluate
R21806 T27763 T27760 punct ),ACTB
R21807 T27764 T27729 pobj genes,of
R21808 T27765 T27719 punct .,extracted
R21809 T27766 T27777 punct (,transfected
R21810 T27767 T27770 compound H,cells
R21811 T27768 T27769 punct ),HeLa
R21812 T27769 T27770 compound HeLa,cells
R21813 T27770 T27777 nsubjpass cells,transfected
R21814 T27771 T27770 punct (,cells
R21815 T27772 T27774 nummod 5,106
R21849 T27806 T27805 prep for,specific
R21850 T27807 T27809 det the,promoters
R21851 T27808 T27809 amod indicated,promoters
R21852 T27809 T27806 pobj promoters,for
R21853 T27810 T27802 punct .,performed
R21854 T27811 T27814 punct (,HeLa
R21855 T27812 T27814 nsubj I,HeLa
R21856 T27813 T27814 punct ),HeLa
R21857 T27814 T27822 nsubjpass HeLa,transfected
R21858 T27815 T27814 dobj cells,HeLa
R21859 T27816 T27815 punct (,cells
R21860 T27817 T27819 nummod 5,106
R21861 T27818 T27819 nummod ×,106
R21862 T27819 T27815 appos 106,cells
R21863 T27820 T27815 punct ),cells
R21864 T27821 T27822 auxpass were,transfected
R21865 T27822 T27855 ccomp transfected,performed
R21866 T27823 T27822 prep with,transfected
R21867 T27824 T27825 amod empty,vector
R21868 T27825 T27823 pobj vector,with
R21869 T27826 T27825 punct ",",vector
R21870 T27827 T27825 cc or,vector
R21871 T27828 T27825 conj p3xFLAG-Tat,vector
R21872 T27829 T27828 punct (,p3xFLAG-Tat
R21873 T27830 T27831 nummod 10,µg
R21874 T27831 T27828 appos µg,p3xFLAG-Tat
R21875 T27832 T27828 punct ),p3xFLAG-Tat
R21876 T27833 T27825 prep in,vector
R21877 T27834 T27833 pobj presence,in
R21878 T27835 T27834 cc or,presence
R21879 T27836 T27834 conj absence,presence
R21880 T27837 T27836 prep of,absence
R21881 T27838 T27839 compound siRNA,p65
R21882 T27839 T27837 pobj p65,of
R21883 T27840 T27839 punct ",",p65
R21884 T27841 T27839 cc or,p65
R21885 T27842 T27843 compound siRNA,control
R21886 T27843 T27839 conj control,p65
R21887 T27844 T27846 punct (,pmol
R21888 T27845 T27846 nummod 200,pmol
R21889 T27846 T27843 appos pmol,control
R21890 T27847 T27822 punct ),transfected
R21891 T27848 T27855 punct ;,performed
R21892 T27849 T27850 nummod 48,h
R21893 T27850 T27851 npadvmod h,later
R21894 T27851 T27855 advmod later,performed
R21895 T27852 T27855 punct ",",performed
R21896 T27853 T27855 nsubjpass ChIP,performed
R21897 T27854 T27855 auxpass was,performed
R21898 T27855 T27855 ROOT performed,performed
R21899 T27856 T27855 prep with,performed
R21900 T27857 T27858 amod anti-FLAG,antibody
R21901 T27858 T27856 pobj antibody,with
R21902 T27859 T27855 punct .,performed
R21903 T27860 T27861 compound Real-time,PCR
R21904 T27861 T27863 nsubjpass PCR,performed
R21905 T27862 T27863 auxpass was,performed
R21906 T27863 T27863 ROOT performed,performed
R21907 T27864 T27863 prep with,performed
R21908 T27865 T27864 pobj primers,with
R21909 T27866 T27865 amod specific,primers
R21910 T27867 T27866 prep for,specific
R21911 T27868 T27870 det the,promoters
R21912 T27869 T27870 amod indicated,promoters
R21913 T27870 T27867 pobj promoters,for
R21914 T27871 T27863 punct .,performed
R21915 T27872 T27883 punct (,transfected
R21916 T27873 T27876 compound J,cells
R21917 T27874 T27875 punct ),HeLa
R21918 T27875 T27876 compound HeLa,cells
R21919 T27876 T27883 nsubjpass cells,transfected
R21920 T27877 T27876 punct (,cells
R21921 T27878 T27880 nummod 5,106
R21922 T27879 T27880 nummod ×,106
R21923 T27880 T27876 appos 106,cells
R21924 T27881 T27876 punct ),cells
R21925 T27882 T27883 auxpass were,transfected
R21926 T27883 T27914 advcl transfected,performed
R21927 T27884 T27883 prep with,transfected
R21928 T27885 T27886 amod empty,vector
R21929 T27886 T27884 pobj vector,with
R21930 T27887 T27886 punct ",",vector
R21931 T27888 T27886 conj p3xFLAG-Tat,vector
R21932 T27889 T27888 punct (,p3xFLAG-Tat
R21933 T27890 T27891 nummod 10,µg
R21934 T27891 T27888 appos µg,p3xFLAG-Tat
R21935 T27892 T27888 punct ),p3xFLAG-Tat
R21936 T27893 T27888 punct ",",p3xFLAG-Tat
R21937 T27894 T27888 cc or,p3xFLAG-Tat
R21938 T27895 T27896 amod empty,vector
R21939 T27896 T27888 conj vector,p3xFLAG-Tat
R21940 T27897 T27896 cc plus,vector
R21941 T27898 T27899 compound siRNA,IκB-α
R21942 T27899 T27896 conj IκB-α,vector
R21943 T27900 T27899 cc or,IκB-α
R21944 T27901 T27902 compound siRNA,control
R21945 T27902 T27899 conj control,IκB-α
R21946 T27903 T27902 punct (,control
R21947 T27904 T27905 nummod 200,pmol
R21948 T27905 T27902 appos pmol,control
R21949 T27906 T27902 punct ),control
R21950 T27907 T27899 punct ;,IκB-α
R21951 T27908 T27909 nummod 48,h
R21952 T27909 T27910 npadvmod h,later
R21953 T27910 T27899 conj later,IκB-α
R21954 T27911 T27914 punct ",",performed
R21955 T27912 T27914 nsubjpass ChIP,performed
R21956 T27913 T27914 auxpass was,performed
R21957 T27914 T27914 ROOT performed,performed
R21958 T27915 T27914 prep with,performed
R21959 T27916 T27917 amod anti-IκB-α,antibody
R21960 T27917 T27915 pobj antibody,with
R21961 T27918 T27914 punct .,performed
R21962 T27919 T27920 compound Real-time,PCR
R21963 T27920 T27922 nsubjpass PCR,performed
R21964 T27921 T27922 auxpass was,performed
R21965 T27922 T27922 ROOT performed,performed
R21966 T27923 T27922 prep with,performed
R21967 T27924 T27923 pobj primers,with
R21968 T27925 T27924 amod specific,primers
R21969 T27926 T27925 prep for,specific
R21970 T27927 T27929 det the,promoters
R21971 T27928 T27929 amod indicated,promoters
R21972 T27929 T27926 pobj promoters,for
R21973 T27930 T27922 punct .,performed
R21974 T27931 T27942 nsubjpass Values,shown
R21975 T27932 T27935 punct (,SE
R21976 T27933 T27935 amod mean,SE
R21977 T27934 T27935 compound ±,SE
R21978 T27935 T27931 appos SE,Values
R21979 T27936 T27935 punct ",",SE
R21980 T27937 T27935 appos n,SE
R21981 T27938 T27939 punct =,3
R21982 T27939 T27937 nummod 3,n
R21983 T27940 T27935 punct ),SE
R21984 T27941 T27942 auxpass are,shown
R21985 T27942 T27942 ROOT shown,shown
R21986 T27943 T27942 punct .,shown
R21987 T27944 T27945 det The,asterisks
R21988 T27945 T27946 nsubj asterisks,indicate
R21989 T27946 T27946 ROOT indicate,indicate
R21990 T27947 T27948 advmod statistically,significant
R21991 T27948 T27949 amod significant,differences
R21992 T27949 T27946 dobj differences,indicate
R21993 T27950 T27949 acl compared,differences
R21994 T27951 T27950 prep to,compared
R21995 T27952 T27953 det the,control
R21996 T27953 T27951 pobj control,to
R21997 T27954 T27953 punct (,control
R21998 T27955 T27956 amod empty,vector
R21999 T27956 T27953 appos vector,control
R22000 T27957 T27953 punct ),control
R22001 T27958 T27946 prep according,indicate
R22002 T27959 T27958 prep to,according
R22003 T27960 T27961 det the,Student
R22004 T27961 T27963 poss Student,t-test
R22005 T27962 T27961 case 's,Student
R22006 T27963 T27959 pobj t-test,to
R22007 T27964 T27963 punct (,t-test
R22008 T27965 T27968 nmod P,)
R22009 T27966 T27965 nummod <,P
R22010 T27967 T27965 nummod 0.05,P
R22011 T27968 T27963 punct ),t-test
R22012 T27969 T27946 punct .,indicate
R22137 T28367 T28371 prep In,sustains
R22138 T28368 T28369 compound HIV-1,infection
R22139 T28369 T28367 pobj infection,In
R22140 T28370 T28371 nsubj Tat,sustains
R22141 T28371 T28371 ROOT sustains,sustains
R22142 T28372 T28374 det the,activity
R22143 T28373 T28374 amod NF-κB,activity
R22144 T28374 T28371 dobj activity,sustains
R22145 T28375 T28371 cc and,sustains
R22146 T28376 T28371 conj enhances,sustains
R22147 T28377 T28379 det the,expression
R22148 T28378 T28379 amod MIP-1α,expression
R22149 T28379 T28376 dobj expression,enhances
R22150 T28380 T28376 prep via,enhances
R22151 T28381 T28380 pobj interaction,via
R22152 T28382 T28381 prep with,interaction
R22153 T28383 T28382 pobj IκB-α,with
R22154 T28384 T28383 cc and,IκB-α
R22155 T28385 T28383 conj p65,IκB-α
R22156 T28386 T28371 punct .,sustains
R22157 T28387 T28388 nummod U937,cells
R22158 T28388 T28395 nsubjpass cells,transfected
R22159 T28389 T28388 punct (,cells
R22160 T28390 T28392 quantmod 5,107
R22161 T28391 T28392 quantmod ×,107
R22162 T28392 T28388 appos 107,cells
R22163 T28393 T28388 punct ),cells
R22164 T28394 T28395 auxpass were,transfected
R22165 T28395 T28416 ccomp transfected,infected
R22166 T28396 T28395 prep with,transfected
R22167 T28397 T28398 compound siRNA,Tat
R22168 T28398 T28396 pobj Tat,with
R22169 T28399 T28395 punct ",",transfected
R22170 T28400 T28401 compound siRNA,control
R22171 T28401 T28395 appos control,transfected
R22172 T28402 T28404 punct (,nmol
R22173 T28403 T28404 nummod 2,nmol
R22174 T28404 T28401 appos nmol,control
R22175 T28405 T28401 punct ),control
R22176 T28406 T28401 punct ",",control
R22177 T28407 T28395 cc or,transfected
R22178 T28408 T28395 conj left,transfected
R22179 T28409 T28408 oprd untransfected,left
R22180 T28410 T28416 punct ;,infected
R22181 T28411 T28412 nummod 24,h
R22182 T28412 T28416 npadvmod h,infected
R22183 T28413 T28414 amod later,cells
R22184 T28414 T28416 nsubjpass cells,infected
R22185 T28415 T28416 auxpass were,infected
R22186 T28416 T28416 ROOT infected,infected
R22187 T28417 T28416 prep with,infected
R22188 T28418 T28419 amod HXB2-pseudotyped,NL4-3
R22189 T28419 T28417 pobj NL4-3,with
R22190 T28420 T28416 punct .,infected
R22191 T28421 T28421 ROOT FLAG-Tat,FLAG-Tat
R22192 T28422 T28421 punct .,FLAG-Tat
R22193 T28423 T28423 ROOT R,R
R22194 T28424 T28435 nsubj −,harvested
R22195 T28425 T28426 compound E,−
R22196 T28426 T28427 nummod −,virions
R22197 T28427 T28424 appos virions,−
R22198 T28428 T28430 punct (,ng
R22199 T28429 T28430 nummod 500,ng
R22200 T28430 T28427 parataxis ng,virions
R22201 T28431 T28430 prep of,ng
R22202 T28432 T28431 pobj p24,of
R22203 T28433 T28430 punct ),ng
R22204 T28434 T28424 cc and,−
R22205 T28435 T28423 acl harvested,R
R22206 T28436 T28435 prep at,harvested
R22207 T28437 T28439 det the,time
R22208 T28438 T28439 amod indicated,time
R22209 T28439 T28436 pobj time,at
R22210 T28440 T28423 punct .,R
R22211 T28441 T28442 punct (,A
R22212 T28442 T28442 ROOT A,A
R22213 T28443 T28442 punct ),A
R22214 T28444 T28445 amod Real-time,PCR
R22215 T28445 T28449 nsubj PCR,measured
R22216 T28446 T28445 prep of,PCR
R22217 T28447 T28448 amod total,RNA
R22218 T28448 T28446 pobj RNA,of
R22219 T28449 T28455 ccomp measured,measured
R22220 T28450 T28452 det the,expression
R22221 T28451 T28452 compound Tat,expression
R22222 T28452 T28449 dobj expression,measured
R22223 T28453 T28455 punct ;,measured
R22224 T28454 T28455 nsubj ELISA,measured
R22225 T28455 T28455 ROOT measured,measured
R22226 T28456 T28457 det the,amount
R22227 T28457 T28455 dobj amount,measured
R22228 T28458 T28457 prep of,amount
R22229 T28459 T28458 pobj p24,of
R22230 T28460 T28459 prep in,p24
R22231 T28461 T28463 amod whole,extracts
R22232 T28462 T28463 compound cell,extracts
R22233 T28463 T28460 pobj extracts,in
R22234 T28464 T28455 punct .,measured
R22235 T28465 T28466 punct (,B
R22236 T28466 T28466 ROOT B,B
R22237 T28467 T28466 punct ),B
R22238 T28468 T28469 det The,binding
R22239 T28469 T28478 nsubjpass binding,measured
R22240 T28470 T28469 prep of,binding
R22241 T28471 T28470 pobj p65,of
R22242 T28472 T28469 prep to,binding
R22243 T28473 T28476 det the,oligonucleotide
R22244 T28474 T28476 nmod NF-κB,oligonucleotide
R22245 T28475 T28476 amod double-stranded,oligonucleotide
R22246 T28476 T28472 pobj oligonucleotide,to
R22247 T28477 T28478 auxpass was,measured
R22248 T28478 T28478 ROOT measured,measured
R22249 T28479 T28478 prep in,measured
R22250 T28480 T28481 amod nuclear,extracts
R22251 T28481 T28479 pobj extracts,in
R22252 T28482 T28481 punct (,extracts
R22253 T28483 T28484 nummod 10,µg
R22254 T28484 T28481 appos µg,extracts
R22255 T28485 T28481 punct ),extracts
R22256 T28486 T28478 advcl using,measured
R22257 T28487 T28493 det the,kit
R22258 T28488 T28491 compound NF-κB,ELISA
R22259 T28489 T28491 compound Transcription,ELISA
R22260 T28490 T28491 compound Factor,ELISA
R22261 T28491 T28493 compound ELISA,kit
R22262 T28492 T28493 compound assay,kit
R22263 T28493 T28486 dobj kit,using
R22264 T28494 T28493 punct (,kit
R22265 T28495 T28493 appos Cayman,kit
R22266 T28496 T28493 punct ),kit
R22267 T28497 T28478 punct .,measured
R22268 T28498 T28499 punct (,C
R22269 T28499 T28499 ROOT C,C
R22270 T28500 T28499 punct ),C
R22271 T28501 T28503 det The,content
R22272 T28502 T28503 amod IκB-α,content
R22273 T28503 T28505 nsubjpass content,analysed
R22274 T28504 T28505 auxpass was,analysed
R22275 T28505 T28505 ROOT analysed,analysed
R22276 T28506 T28505 prep by,analysed
R22277 T28507 T28508 nummod 12,%
R22278 T28508 T28509 compound %,SDS
R22279 T28509 T28506 pobj SDS,by
R22280 T28510 T28509 conj PAGE,SDS
R22281 T28511 T28510 cc and,PAGE
R22282 T28512 T28513 amod western,blotting
R22283 T28513 T28510 conj blotting,PAGE
R22284 T28514 T28513 prep of,blotting
R22285 T28515 T28516 amod cytosolic,extracts
R22286 T28516 T28514 pobj extracts,of
R22287 T28517 T28516 punct (,extracts
R22288 T28518 T28519 nummod 20,µg
R22289 T28519 T28516 appos µg,extracts
R22290 T28520 T28516 punct ),extracts
R22291 T28521 T28505 advcl using,analysed
R22292 T28522 T28523 amod anti-IκB-α,antibody
R22293 T28523 T28521 dobj antibody,using
R22294 T28524 T28505 punct .,analysed
R22295 T28525 T28526 compound Densitometry,values
R22296 T28526 T28534 nsubjpass values,expressed
R22297 T28527 T28528 punct (,D
R22298 T28528 T28526 appos D,values
R22299 T28529 T28528 punct ),D
R22300 T28530 T28528 prep of,D
R22301 T28531 T28532 det the,bands
R22302 T28532 T28530 pobj bands,of
R22303 T28533 T28534 auxpass were,expressed
R22304 T28534 T28534 ROOT expressed,expressed
R22305 T28535 T28536 mark as,fold
R22306 T28536 T28534 advcl fold,expressed
R22307 T28537 T28536 dobj increase,fold
R22308 T28538 T28536 prep above,fold
R22309 T28539 T28540 det the,control
R22310 T28540 T28538 pobj control,above
R22311 T28541 T28540 punct (,control
R22312 T28542 T28540 amod mock,control
R22313 T28543 T28540 punct ),control
R22314 T28544 T28534 punct .,expressed
R22315 T28545 T28551 punct (,measured
R22316 T28546 T28549 compound D,activity
R22317 T28547 T28548 punct ),IKK
R22318 T28548 T28549 compound IKK,activity
R22319 T28549 T28551 nsubjpass activity,measured
R22320 T28550 T28551 auxpass was,measured
R22321 T28551 T28551 ROOT measured,measured
R22322 T28552 T28551 prep in,measured
R22323 T28553 T28554 amod cytosolic,cell
R22324 T28554 T28555 compound cell,extracts
R22325 T28555 T28552 pobj extracts,in
R22326 T28556 T28555 punct (,extracts
R22327 T28557 T28558 nummod 100,µg
R22328 T28558 T28555 appos µg,extracts
R22329 T28559 T28555 punct ),extracts
R22330 T28560 T28551 advcl using,measured
R22331 T28561 T28564 compound HTScan,Assay
R22332 T28562 T28564 compound IKK,Assay
R22333 T28563 T28564 compound Kinase,Assay
R22334 T28564 T28560 dobj Assay,using
R22335 T28565 T28568 punct (,Technology
R22336 T28566 T28568 compound Cell,Technology
R22337 T28567 T28568 compound Signaling,Technology
R22338 T28568 T28564 appos Technology,Assay
R22339 T28569 T28564 punct ),Assay
R22340 T28570 T28551 punct .,measured
R22341 T28571 T28582 punct (,infected
R22342 T28572 T28575 nmod E,cells
R22343 T28573 T28572 punct ),E
R22344 T28574 T28575 compound U937,cells
R22345 T28575 T28582 nsubjpass cells,infected
R22346 T28576 T28575 punct (,cells
R22347 T28577 T28579 nummod 5,107
R22348 T28578 T28579 quantmod ×,107
R22349 T28579 T28575 appos 107,cells
R22350 T28580 T28575 punct ),cells
R22351 T28581 T28582 auxpass were,infected
R22352 T28582 T28582 ROOT infected,infected
R22353 T28583 T28582 prep with,infected
R22354 T28584 T28585 amod HXB2-pseudotyped,NL4-3
R22355 T28585 T28583 pobj NL4-3,with
R22356 T28586 T28582 punct .,infected
R22357 T28587 T28587 ROOT FLAG-Tat,FLAG-Tat
R22358 T28588 T28587 punct .,FLAG-Tat
R22359 T28589 T28593 nmod R,virions
R22360 T28590 T28593 nummod −,virions
R22361 T28591 T28592 compound E,−
R22362 T28592 T28593 nummod −,virions
R22363 T28593 T28596 nsubj virions,left
R22364 T28594 T28593 punct ",",virions
R22365 T28595 T28593 cc or,virions
R22366 T28596 T28596 ROOT left,left
R22367 T28597 T28596 oprd uninfected,left
R22368 T28598 T28596 punct .,left
R22369 T28599 T28600 nummod Twenty-four-hour,post-infection
R22370 T28600 T28609 nsubjpass post-infection,immunoprecipitated
R22371 T28601 T28603 punct ",",extracts
R22372 T28602 T28603 compound cell,extracts
R22373 T28603 T28600 appos extracts,post-infection
R22374 T28604 T28603 punct (,extracts
R22375 T28605 T28606 nummod 1,mg
R22376 T28606 T28603 appos mg,extracts
R22377 T28607 T28603 punct ),extracts
R22378 T28608 T28609 auxpass were,immunoprecipitated
R22379 T28609 T28609 ROOT immunoprecipitated,immunoprecipitated
R22380 T28610 T28609 prep with,immunoprecipitated
R22381 T28611 T28614 nmod protein,antibody
R22382 T28612 T28614 amod G-Sepharose-coupled,antibody
R22383 T28613 T28614 amod anti-FLAG,antibody
R22384 T28614 T28610 pobj antibody,with
R22385 T28615 T28609 punct .,immunoprecipitated
R22386 T28616 T28618 nsubjpass Immunocomplexes,separated
R22387 T28617 T28618 auxpass were,separated
R22388 T28618 T28618 ROOT separated,separated
R22389 T28619 T28618 prep by,separated
R22390 T28620 T28621 nummod 12,%
R22391 T28621 T28619 pobj %,by
R22392 T28622 T28623 compound SDS,PAGE
R22393 T28623 T28618 npadvmod PAGE,separated
R22394 T28624 T28623 cc and,PAGE
R22395 T28625 T28623 conj analysed,PAGE
R22396 T28626 T28625 agent by,analysed
R22397 T28627 T28628 amod western,blotting
R22398 T28628 T28626 pobj blotting,by
R22399 T28629 T28628 prep with,blotting
R22400 T28630 T28635 amod anti-p65,antibodies
R22401 T28631 T28630 punct ",",anti-p65
R22402 T28632 T28630 conj anti-FLAG,anti-p65
R22403 T28633 T28632 cc and,anti-FLAG
R22404 T28634 T28632 conj anti-IκB-α,anti-FLAG
R22405 T28635 T28629 pobj antibodies,with
R22406 T28636 T28618 punct .,separated
R22407 T28637 T28648 punct (,transfected
R22408 T28638 T28641 compound F,cells
R22409 T28639 T28640 punct ),U937
R22410 T28640 T28641 compound U937,cells
R22411 T28641 T28648 nsubjpass cells,transfected
R22412 T28642 T28641 punct (,cells
R22413 T28643 T28645 quantmod 5,107
R22414 T28644 T28645 quantmod ×,107
R22415 T28645 T28641 appos 107,cells
R22416 T28646 T28641 punct ),cells
R22417 T28647 T28648 auxpass were,transfected
R22418 T28648 T28673 ccomp transfected,infected
R22419 T28649 T28648 prep with,transfected
R22420 T28650 T28651 compound siRNA,Tat
R22421 T28651 T28649 pobj Tat,with
R22422 T28652 T28648 punct ",",transfected
R22423 T28653 T28648 dep siRNA,transfected
R22424 T28654 T28653 appos p65,siRNA
R22425 T28655 T28653 punct ",",siRNA
R22426 T28656 T28657 compound siRNA,control
R22427 T28657 T28653 appos control,siRNA
R22428 T28658 T28660 punct (,nmol
R22429 T28659 T28660 nummod 2,nmol
R22430 T28660 T28657 appos nmol,control
R22431 T28661 T28657 punct ),control
R22432 T28662 T28653 punct ",",siRNA
R22433 T28663 T28648 cc or,transfected
R22434 T28664 T28648 conj left,transfected
R22435 T28665 T28664 oprd untransfected,left
R22436 T28666 T28673 punct ;,infected
R22437 T28667 T28668 nummod 24,h
R22438 T28668 T28669 npadvmod h,later
R22439 T28669 T28673 advmod later,infected
R22440 T28670 T28673 punct ",",infected
R22441 T28671 T28673 nsubjpass cells,infected
R22442 T28672 T28673 auxpass were,infected
R22443 T28673 T28673 ROOT infected,infected
R22444 T28674 T28673 prep with,infected
R22445 T28675 T28676 amod HXB2-pseudotyped,NL4-3
R22446 T28676 T28674 pobj NL4-3,with
R22447 T28677 T28673 punct .,infected
R22448 T28678 T28678 ROOT FLAG-Tat,FLAG-Tat
R22449 T28679 T28678 punct .,FLAG-Tat
R22450 T28680 T28684 nmod R,virions
R22451 T28681 T28684 nummod −,virions
R22452 T28682 T28683 compound E,−
R22453 T28683 T28684 nummod −,virions
R22454 T28684 T28687 nsubj virions,left
R22455 T28685 T28684 punct ",",virions
R22456 T28686 T28684 cc or,virions
R22457 T28687 T28687 ROOT left,left
R22458 T28688 T28687 oprd uninfected,left
R22459 T28689 T28687 punct .,left
R22460 T28690 T28691 nummod Twenty-four-hour,post-infection
R22461 T28691 T28695 nsubj post-infection,was
R22462 T28692 T28691 punct ",",post-infection
R22463 T28693 T28694 amod total,RNA
R22464 T28694 T28691 appos RNA,post-infection
R22465 T28695 T28695 ROOT was,was
R22466 T28696 T28695 attr analysed,was
R22467 T28697 T28696 prep for,analysed
R22468 T28698 T28699 amod MIP-1α,expression
R22469 T28699 T28697 pobj expression,for
R22470 T28700 T28699 prep by,expression
R22471 T28701 T28702 amod real-time,PCR
R22472 T28702 T28700 pobj PCR,by
R22473 T28703 T28695 punct .,was
R22474 T28704 T28709 punct (,U937
R22475 T28705 T28709 nmod G,U937
R22476 T28706 T28705 cc and,G
R22477 T28707 T28705 conj H,G
R22478 T28708 T28709 punct ),U937
R22479 T28709 T28710 compound U937,cells
R22480 T28710 T28717 nsubjpass cells,transfected
R22481 T28711 T28710 punct (,cells
R22482 T28712 T28714 quantmod 5,107
R22483 T28713 T28714 quantmod ×,107
R22484 T28714 T28710 appos 107,cells
R22485 T28715 T28710 punct ),cells
R22486 T28716 T28717 auxpass were,transfected
R22487 T28717 T28739 ccomp transfected,infected
R22488 T28718 T28717 prep with,transfected
R22489 T28719 T28720 compound siRNA,Tat
R22490 T28720 T28718 pobj Tat,with
R22491 T28721 T28720 cc or,Tat
R22492 T28722 T28723 compound siRNA,control
R22493 T28723 T28720 conj control,Tat
R22494 T28724 T28726 punct (,nmol
R22495 T28725 T28726 nummod 2,nmol
R22496 T28726 T28723 appos nmol,control
R22497 T28727 T28726 punct ),nmol
R22498 T28728 T28723 punct ",",control
R22499 T28729 T28723 cc or,control
R22500 T28730 T28717 advcl left,transfected
R22501 T28731 T28730 oprd untransfected,left
R22502 T28732 T28739 punct ;,infected
R22503 T28733 T28734 nummod 24,h
R22504 T28734 T28735 npadvmod h,later
R22505 T28735 T28739 advmod later,infected
R22506 T28736 T28739 punct ",",infected
R22507 T28737 T28739 nsubjpass cells,infected
R22508 T28738 T28739 auxpass were,infected
R22509 T28739 T28739 ROOT infected,infected
R22510 T28740 T28739 prep with,infected
R22511 T28741 T28742 amod HXB2-pseudotyped,NL4-3
R22512 T28742 T28740 pobj NL4-3,with
R22513 T28743 T28739 punct .,infected
R22514 T28744 T28744 ROOT FLAG-Tat,FLAG-Tat
R22515 T28745 T28744 punct .,FLAG-Tat
R22516 T28746 T28750 nmod R,virions
R22517 T28747 T28750 nummod −,virions
R22518 T28748 T28749 compound E,−
R22519 T28749 T28750 nummod −,virions
R22520 T28750 T28753 nsubj virions,left
R22521 T28751 T28750 punct ",",virions
R22522 T28752 T28750 cc or,virions
R22523 T28753 T28753 ROOT left,left
R22524 T28754 T28753 oprd uninfected,left
R22525 T28755 T28753 punct .,left
R22526 T28756 T28757 nummod Twenty-four-hour,post-infection
R22527 T28757 T28761 npadvmod post-infection,performed
R22528 T28758 T28761 punct ",",performed
R22529 T28759 T28761 nsubjpass ChIP,performed
R22530 T28760 T28761 auxpass was,performed
R22531 T28761 T28761 ROOT performed,performed
R22532 T28762 T28761 prep with,performed
R22533 T28763 T28762 pobj anti-p65,with
R22534 T28764 T28765 punct (,G
R22535 T28765 T28763 appos G,anti-p65
R22536 T28766 T28761 punct ),performed
R22537 T28767 T28761 cc or,performed
R22538 T28768 T28761 conj anti-FLAG,performed
R22539 T28769 T28770 punct (,H
R22540 T28770 T28768 appos H,anti-FLAG
R22541 T28771 T28768 punct ),anti-FLAG
R22542 T28772 T28761 punct .,performed
R22543 T28773 T28774 compound Real-time,PCR
R22544 T28774 T28776 nsubjpass PCR,performed
R22545 T28775 T28776 auxpass was,performed
R22546 T28776 T28776 ROOT performed,performed
R22547 T28777 T28776 prep with,performed
R22548 T28778 T28777 pobj primers,with
R22549 T28779 T28778 amod specific,primers
R22550 T28780 T28779 prep for,specific
R22551 T28781 T28780 pobj MIP-1α,for
R22552 T28782 T28781 cc and,MIP-1α
R22553 T28783 T28781 conj GAPDH,MIP-1α
R22554 T28784 T28778 conj promoters,primers
R22555 T28785 T28776 punct .,performed
R22556 T28786 T28797 nsubjpass Values,shown
R22557 T28787 T28790 punct (,SE
R22558 T28788 T28790 amod mean,SE
R22559 T28789 T28790 compound ±,SE
R22560 T28790 T28786 appos SE,Values
R22561 T28791 T28790 punct ",",SE
R22562 T28792 T28797 nsubjpass n,shown
R22563 T28793 T28794 punct =,3
R22564 T28794 T28792 advmod 3,n
R22565 T28795 T28797 punct ),shown
R22566 T28796 T28797 auxpass are,shown
R22567 T28797 T28797 ROOT shown,shown
R22568 T28798 T28797 punct .,shown
R22569 T28799 T28800 det The,asterisks
R22570 T28800 T28801 nsubj asterisks,indicate
R22571 T28801 T28801 ROOT indicate,indicate
R22572 T28802 T28803 advmod statistically,significant
R22573 T28803 T28804 amod significant,differences
R22574 T28804 T28801 dobj differences,indicate
R22575 T28805 T28804 acl compared,differences
R22576 T28806 T28805 prep to,compared
R22577 T28807 T28808 det the,control
R22578 T28808 T28806 pobj control,to
R22579 T28809 T28808 punct (,control
R22580 T28810 T28808 amod mock,control
R22581 T28811 T28808 punct ),control
R22582 T28812 T28801 punct ",",indicate
R22583 T28813 T28801 prep according,indicate
R22584 T28814 T28813 prep to,according
R22585 T28815 T28816 det the,Student
R22586 T28816 T28818 poss Student,t-test
R22587 T28817 T28816 case 's,Student
R22588 T28818 T28814 pobj t-test,to
R22589 T28819 T28818 punct (,t-test
R22590 T28820 T28823 nmod P,)
R22591 T28821 T28820 nummod <,P
R22592 T28822 T28820 nummod 0.05,P
R22593 T28823 T28818 punct ),t-test
R22594 T28824 T28801 punct .,indicate
R22780 T29196 T29196 ROOT Model,Model
R22781 T29197 T29196 prep of,Model
R22782 T29198 T29200 nmod MIP-1α,activation
R22783 T29199 T29200 amod transcriptional,activation
R22784 T29200 T29197 pobj activation,of
R22785 T29201 T29200 prep by,activation
R22786 T29202 T29203 compound HIV-1,Tat
R22787 T29203 T29201 pobj Tat,by
R22788 T29204 T29196 punct .,Model
R22789 T29205 T29206 punct (,A
R22790 T29206 T29206 ROOT A,A
R22791 T29207 T29206 punct ),A
R22792 T29208 T29214 prep In,occupies
R22793 T29209 T29208 pobj absence,In
R22794 T29210 T29209 prep of,absence
R22795 T29211 T29210 pobj Tat,of
R22796 T29212 T29214 punct ",",occupies
R22797 T29213 T29214 nsubj IκB-α,occupies
R22798 T29214 T29214 ROOT occupies,occupies
R22799 T29215 T29217 det the,enhancer
R22800 T29216 T29217 amod NF-κB,enhancer
R22801 T29217 T29214 dobj enhancer,occupies
R22802 T29218 T29217 prep of,enhancer
R22803 T29219 T29221 det the,promoter
R22804 T29220 T29221 amod MIP-1α,promoter
R22805 T29221 T29218 pobj promoter,of
R22806 T29222 T29221 cc and,promoter
R22807 T29223 T29224 amod likely,interacts
R22808 T29224 T29214 conj interacts,occupies
R22809 T29225 T29224 prep with,interacts
R22810 T29226 T29227 amod transcriptional,repressors
R22811 T29227 T29225 pobj repressors,with
R22812 T29228 T29227 punct ",",repressors
R22813 T29229 T29230 amod such,as
R22814 T29230 T29227 prep as,repressors
R22815 T29231 T29230 pobj HDACs,as
R22816 T29232 T29231 punct (,HDACs
R22817 T29233 T29231 appos 65,HDACs
R22818 T29234 T29231 punct ),HDACs
R22819 T29235 T29214 punct ",",occupies
R22820 T29236 T29237 aux to,inhibit
R22821 T29237 T29214 advcl inhibit,occupies
R22822 T29238 T29239 compound gene,transcription
R22823 T29239 T29237 dobj transcription,inhibit
R22824 T29240 T29214 punct .,occupies
R22825 T29241 T29244 punct (,Tat
R22826 T29242 T29244 nmod B,Tat
R22827 T29243 T29244 punct ),Tat
R22828 T29244 T29245 nsubj Tat,activates
R22829 T29245 T29245 ROOT activates,activates
R22830 T29246 T29248 det the,expression
R22831 T29247 T29248 amod MIP-1α,expression
R22832 T29248 T29245 dobj expression,activates
R22833 T29249 T29245 prep by,activates
R22834 T29250 T29249 pcomp removing,by
R22835 T29251 T29253 det the,repressor
R22836 T29252 T29253 amod IκB-α,repressor
R22837 T29253 T29250 dobj repressor,removing
R22838 T29254 T29250 prep from,removing
R22839 T29255 T29257 det the,enhancer
R22840 T29256 T29257 compound NF-κB,enhancer
R22841 T29257 T29254 pobj enhancer,from
R22842 T29258 T29250 punct ",",removing
R22843 T29259 T29249 cc and,by
R22844 T29260 T29249 conj by,by
R22845 T29261 T29260 pcomp increasing,by
R22846 T29262 T29263 det the,binding
R22847 T29263 T29261 dobj binding,increasing
R22848 T29264 T29263 prep of,binding
R22849 T29265 T29267 nummod p65,complex
R22850 T29266 T29267 amod NF-κB,complex
R22851 T29267 T29264 pobj complex,of
R22852 T29268 T29267 prep to,complex
R22853 T29269 T29271 det the,enhancer
R22854 T29270 T29271 amod NF-κB,enhancer
R22855 T29271 T29268 pobj enhancer,to
R22856 T29272 T29245 punct .,activates
R4218 T4664 T4662 conj NIH,NIAID
R21694 T27651 T27652 compound HeLa,cells
R21780 T27737 T27735 appos B,CSF3
R21781 T27738 T27735 punct ),CSF3
R21782 T27739 T27735 punct ",",CSF3
R21783 T27740 T27735 conj LTA,CSF3
R21784 T27741 T27742 punct (,C
R4219 T4665 T4662 punct ",",NIAID
R4220 T4666 T4662 conj USA,NIAID
R4221 T4667 T4672 punct ;,purchased
R4222 T4668 T4672 nsubjpass pκBluc,purchased
R4223 T4669 T4668 cc and,pκBluc
R5134 T5930 T5931 compound CUGCUUGUCACA,AUUGCUAUU
R5596 T6545 T6543 appos Danvers,Technology
R6130 T7260 T7261 compound Bio-Rad,Laboratories
R6131 T7261 T7258 appos Laboratories,mix
R6132 T7262 T7252 punct ),performed
R6133 T7263 T7252 cc and,performed
R6134 T7264 T7252 conj carried,performed
R6135 T7265 T7264 prt out,carried
R6136 T7266 T7264 prep with,carried
R6137 T7267 T7272 det the,system
R6138 T7268 T7270 compound iCycler,Real-Time
R6139 T7269 T7270 compound iQ,Real-Time
R6140 T7270 T7272 compound Real-Time,system
R6141 T7271 T7272 compound detection,system
R6142 T7272 T7266 pobj system,with
R6143 T7273 T7272 punct (,system
R6144 T7274 T7275 compound Bio-Rad,Laboratories
R6145 T7275 T7272 appos Laboratories,system
R6146 T7276 T7272 punct ),system
R6147 T7277 T7264 prep under,carried
R6148 T7278 T7280 det the,conditions
R6149 T7279 T7280 amod following,conditions
R6150 T7280 T7277 pobj conditions,under
R6151 T7281 T7280 punct :,conditions
R6152 T7282 T7283 nummod 95,°
R6153 T7283 T7284 compound °,C
R6154 T7284 T7280 appos C,conditions
R6155 T7285 T7284 punct ",",C
R6156 T7286 T7287 nummod 1,min
R6157 T7287 T7284 appos min,C
R6158 T7288 T7284 punct ;,C
R6159 T7289 T7284 punct (,C
R6160 T7290 T7291 nummod 94,°
R21672 T27629 T27630 nsubj Tat,activates
R21673 T27630 T27630 ROOT activates,activates
R21674 T27631 T27633 det the,expression
R21675 T27632 T27633 amod p65-dependent,expression
R21676 T27633 T27630 dobj expression,activates
R21677 T27634 T27633 prep of,expression
R21678 T27635 T27636 amod NF-κB-responsive,genes
R21679 T27636 T27634 pobj genes,of
R21680 T27637 T27630 prep by,activates
R21681 T27638 T27637 pcomp occupying,by
R21682 T27639 T27641 det the,enhancers
R21683 T27640 T27641 amod NF-κB,enhancers
R21684 T27641 T27638 dobj enhancers,occupying
R21685 T27642 T27638 cc and,occupying
R21686 T27643 T27638 conj promoting,occupying
R21687 T27644 T27646 det the,recruitment
R21688 T27645 T27646 nummod p65,recruitment
R21689 T27646 T27643 dobj recruitment,promoting
R21690 T27647 T27643 prep with,promoting
R21691 T27648 T27649 amod IκB-α,displacement
R21692 T27649 T27647 pobj displacement,with
R21693 T27650 T27630 punct .,activates
R21695 T27652 T27659 nsubjpass cells,transfected
R21696 T27653 T27652 punct (,cells
R21697 T27654 T27656 nummod 5,106
R21698 T27655 T27656 nummod ×,106
R21699 T27656 T27652 appos 106,cells
R21700 T27657 T27652 punct ),cells
R21701 T27658 T27659 auxpass were,transfected
R21702 T27659 T27659 ROOT transfected,transfected
R21703 T27660 T27659 prep with,transfected
R21704 T27661 T27660 pobj p3xFLAG-Tat,with
R21705 T27662 T27659 punct ",",transfected
R21706 T27663 T27664 compound p3xFLAG-Tat,C
R21707 T27664 T27659 npadvmod C,transfected
R21708 T27665 T27664 punct (,C
R21709 T27666 T27664 appos "22,25,27",C
R21710 T27667 T27664 punct ),C
R21711 T27668 T27664 punct ",",C
R21712 T27669 T27670 amod p3xFLAG-Tat,R
R21713 T27670 T27664 appos R,C
R21714 T27671 T27673 punct (,57
R21715 T27672 T27673 nummod 49,57
R21716 T27673 T27670 appos 57,R
R21717 T27674 T27673 punct ),57
R21718 T27675 T27673 cc or,57
R21719 T27676 T27677 amod empty,vector
R21720 T27677 T27673 conj vector,57
R21721 T27678 T27677 punct (,vector
R21722 T27679 T27680 nummod 10,µg
R21723 T27680 T27677 appos µg,vector
R21724 T27681 T27677 punct ),vector
R21725 T27682 T27659 punct ;,transfected
R21726 T27683 T27659 prep for,transfected
R21727 T27684 T27686 nummod p65,interference
R21728 T27685 T27686 compound RNA,interference
R21729 T27686 T27683 pobj interference,for
R21730 T27687 T27686 punct ",",interference
R21731 T27688 T27686 appos cells,interference
R21732 T27689 T27688 punct (,cells
R21733 T27690 T27692 nummod 5,106
R21734 T27691 T27692 nummod ×,106
R21735 T27692 T27688 appos 106,cells
R21736 T27693 T27688 punct ),cells
R21737 T27694 T27695 auxpass were,transfected
R21738 T27695 T27659 conj transfected,transfected
R21739 T27696 T27695 prep with,transfected
R21740 T27697 T27696 pobj p3xFLAG-Tat,with
R21741 T27698 T27697 punct (,p3xFLAG-Tat
R21742 T27699 T27700 nummod 10,µg
R21743 T27700 T27697 appos µg,p3xFLAG-Tat
R21744 T27701 T27697 punct ),p3xFLAG-Tat
R21745 T27702 T27695 cc and,transfected
R21746 T27703 T27695 conj siRNA,transfected
R21747 T27704 T27707 nummod p65,control
R21748 T27705 T27704 cc or,p65
R21749 T27706 T27707 amod siRNA,control
R21750 T27707 T27707 ROOT control,control
R21751 T27708 T27710 punct (,pmol
R21752 T27709 T27710 nummod 200,pmol
R21753 T27710 T27707 appos pmol,control
R21754 T27711 T27710 punct ),pmol
R21755 T27712 T27659 punct .,transfected
R21756 T27713 T27714 nummod Twenty-four-hour,post-transfection
R21757 T27714 T27714 ROOT post-transfection,post-transfection
R21758 T27715 T27714 punct ",",post-transfection
R21759 T27716 T27717 amod total,RNA
R21760 T27717 T27719 nsubjpass RNA,extracted
R21761 T27718 T27719 auxpass was,extracted
R21762 T27719 T27714 conj extracted,post-transfection
R21763 T27720 T27719 cc and,extracted
R21764 T27721 T27719 conj analysed,extracted
R21765 T27722 T27721 agent by,analysed
R21766 T27723 T27724 amod real-time,PCR
R21772 T27729 T27728 prep of,expression
R21773 T27730 T27729 pobj MIP-1α,of
R21774 T27731 T27730 punct (,MIP-1α
R21775 T27732 T27730 appos A,MIP-1α
R21776 T27733 T27730 punct ),MIP-1α
R21777 T27734 T27730 punct ",",MIP-1α
R21778 T27735 T27730 conj CSF3,MIP-1α
R21779 T27736 T27737 punct (,B
R21785 T27742 T27740 parataxis C,LTA
R21786 T27743 T27742 punct ),C
R21787 T27744 T27740 punct ",",LTA
R21788 T27745 T27740 conj NFKBIA,LTA
R21789 T27746 T27747 punct (,D
R21790 T27747 T27745 appos D,NFKBIA
R21791 T27748 T27745 punct ),NFKBIA
R21792 T27749 T27745 punct ",",NFKBIA
R21793 T27750 T27745 conj TLR2,NFKBIA
R21794 T27751 T27752 punct (,E
R21795 T27752 T27750 appos E,TLR2
R21796 T27753 T27750 punct ),TLR2
R21797 T27754 T27750 punct ",",TLR2
R21798 T27755 T27750 conj GAPDH,TLR2
R21799 T27756 T27757 punct (,F
R21800 T27757 T27755 appos F,GAPDH
R21801 T27758 T27755 punct ),GAPDH
R21802 T27759 T27755 punct ",",GAPDH
R21803 T27760 T27755 conj ACTB,GAPDH
R21804 T27761 T27762 punct (,G
R21805 T27762 T27760 appos G,ACTB
R21816 T27773 T27774 nummod ×,106
R21817 T27774 T27770 appos 106,cells
R21818 T27775 T27770 punct ),cells
R21819 T27776 T27777 auxpass were,transfected
R21820 T27777 T27777 ROOT transfected,transfected
R21821 T27778 T27777 prep with,transfected
R21822 T27779 T27778 pobj p3xFLAG-Tat,with
R21823 T27780 T27779 punct ",",p3xFLAG-Tat
R21824 T27781 T27779 cc or,p3xFLAG-Tat
R21825 T27782 T27783 amod empty,vector
R21826 T27783 T27779 conj vector,p3xFLAG-Tat
R21827 T27784 T27786 punct (,µg
R21828 T27785 T27786 nummod 10,µg
R21829 T27786 T27779 appos µg,p3xFLAG-Tat
R21830 T27787 T27786 punct ),µg
R21831 T27788 T27779 cc and,p3xFLAG-Tat
R21832 T27789 T27790 nummod 48,h
R21833 T27790 T27791 npadvmod h,later
R21834 T27791 T27794 advmod later,performed
R21835 T27792 T27794 nsubjpass ChIP,performed
R21836 T27793 T27794 auxpass was,performed
R21837 T27794 T27777 conj performed,transfected
R21838 T27795 T27794 prep with,performed
R21839 T27796 T27797 amod anti-p65,antibody
R21840 T27797 T27795 pobj antibody,with
R21841 T27798 T27794 punct .,performed
R21842 T27799 T27800 compound Real-time,PCR
R21843 T27800 T27802 nsubjpass PCR,performed
R21844 T27801 T27802 auxpass was,performed
R21845 T27802 T27802 ROOT performed,performed
R21846 T27803 T27802 prep with,performed
R21847 T27804 T27803 pobj primers,with
R21848 T27805 T27804 amod specific,primers
R6632 T7911 T7910 agent by,purified
R6633 T7912 T7915 compound QIAquick,kit
R6634 T7913 T7915 compound PCR,kit
R6635 T7914 T7915 compound purification,kit
R6636 T7915 T7911 pobj kit,by
R6637 T7916 T7915 punct (,kit
R6638 T7917 T7915 appos QIAGEN,kit
R6639 T7918 T7915 punct ),kit
R6640 T7919 T7910 cc and,purified
R6641 T7920 T7910 conj eluted,purified
R6642 T7921 T7920 prep in,eluted
R6643 T7922 T7923 nummod 50,µl
R6644 T7923 T7924 npadvmod µl,sterile
R6645 T7924 T7926 amod sterile,water
R6646 T7925 T7926 compound distilled,water
R6647 T7926 T7921 pobj water,in
R6648 T7927 T7910 punct .,purified
R6649 T7928 T7929 amod Specific,enrichment
R8231 T9891 T9890 pobj PBMCs,of
R8232 T9892 T9885 advcl using,observed
R8233 T9893 T9894 det a,cocktail
R8234 T9894 T9892 dobj cocktail,using
R8235 T9895 T9894 prep of,cocktail
R8236 T9896 T9895 pobj Azidothymidine,of
R8237 T9897 T9896 punct (,Azidothymidine
R8238 T9898 T9896 appos AZT,Azidothymidine
R8239 T9899 T9896 punct ),Azidothymidine
R8240 T9900 T9896 cc and,Azidothymidine
R8241 T9901 T9896 conj Lamivudine,Azidothymidine
R8242 T9902 T9901 punct (,Lamivudine
R8243 T9903 T9901 appos 3TC,Lamivudine
R8244 T9904 T9901 punct ),Lamivudine
R8245 T9905 T9892 prep as,using
R8246 T9906 T9908 compound reverse,inhibitors
R8247 T9907 T9908 compound transcriptase,inhibitors
R8248 T9908 T9905 pobj inhibitors,as
R8249 T9909 T9912 punct (,S2
R8250 T9910 T9912 compound Supplementary,S2
R8471 T10131 T10131 ROOT bound,bound
R8472 T10132 T10131 prep to,bound
R8473 T10133 T10135 det the,oligonucleotide
R8474 T10134 T10135 amod NF-κB,oligonucleotide
R8475 T10135 T10132 pobj oligonucleotide,to
R8476 T10136 T10135 prep in,oligonucleotide
R8477 T10137 T10138 amod un-stimulated,cells
R8478 T10138 T10136 pobj cells,in
R8479 T10139 T10135 cc and,oligonucleotide
R8544 T10204 T10178 punct .,followed
R8546 T10205 T10210 advmod Consistently,started
R8548 T10206 T10210 punct ",",started
R8551 T10207 T10209 det the,activation
R8555 T10208 T10209 compound IKK,activation
R8559 T10209 T10210 nsubj activation,started
R8563 T10210 T10210 ROOT started,started
R8567 T10211 T10210 prep at,started
R8570 T10212 T10213 nummod 5,min
R8573 T10213 T10211 pobj min,at
R8575 T10214 T10210 punct ",",started
R8578 T10215 T10210 cc and,started
R8585 T10216 T10210 conj turned,started
R8589 T10217 T10216 prt off,turned
R8593 T10218 T10216 prep at,turned
R8596 T10219 T10220 nummod 30,min
R8598 T10220 T10218 pobj min,at
R8601 T10221 T10216 advmod independently,turned
R8604 T10222 T10221 prep of,independently
R8608 T10223 T10224 det the,presence
R8612 T10224 T10222 pobj presence,of
R11220 T13927 T13927 ROOT A,A
R11221 T13928 T13927 cc and,A
R11222 T13929 T13930 compound Tat,R
R11223 T13930 T13927 conj R,A
R11224 T13942 T13930 punct (,R
R11225 T13943 T13930 appos 49,R
R11226 T13944 T13930 appos 57,R
R11227 T13945 T13930 punct ),R
R11228 T13946 T13946 ROOT A,A
R11229 T13947 T13946 prep at,A
R11230 T13948 T13949 amod similar,levels
R11231 T13949 T13947 pobj levels,at
R11232 T13950 T13946 punct ",",A
R11233 T13951 T13958 mark while,observed
R11234 T13952 T13954 det a,decrease
R11235 T13953 T13954 amod significant,decrease
R11236 T13954 T13958 nsubjpass decrease,observed
R11237 T13955 T13954 prep in,decrease
R11238 T13956 T13955 pobj coimmunoprecipitation,in
R11239 T13957 T13958 auxpass was,observed
R11240 T13958 T13946 advcl observed,A
R11241 T13959 T13958 prep for,observed
R11242 T13960 T13961 compound Tat,C
R11243 T13961 T13959 pobj C,for
R11244 T13962 T13961 punct (,C
R11245 T13963 T13961 appos "22,25,27",C
R11246 T13964 T13961 punct ),C
R11247 T13965 T13968 det A,4A
R11248 T13966 T13968 punct (,4A
R11249 T13967 T13968 nmod Figure,4A
R11250 T13968 T13968 ROOT 4A,4A
R11251 T13969 T13968 punct ),4A
R11252 T13970 T13968 punct .,4A
R11253 T13971 T13980 advmod Consistently,showed
R11254 T13972 T13980 punct ",",showed
R11255 T13973 T13980 nsubj GST-pull,showed
R11256 T13974 T13973 prt down,GST-pull
R11257 T13975 T13973 prep of,GST-pull
R11258 T13976 T13980 prep in,showed
R11259 T13977 T13979 amod vitro,proteins
R11260 T13978 T13979 amod translated,proteins
R11261 T13979 T13976 pobj proteins,in
R11262 T13980 T13980 ROOT showed,showed
R11263 T13981 T13983 det the,binding
R11264 T13982 T13983 amod direct,binding
R11265 T13983 T13980 dobj binding,showed
R11266 T13984 T13983 prep of,binding
R11267 T13985 T13984 pobj p65,of
R11268 T13986 T13987 aux to,wild-type
R11269 T13987 T13983 relcl wild-type,binding
R11270 T13988 T13987 dobj Tat,wild-type
R11271 T13989 T13987 punct ",",wild-type
R11272 T13990 T13983 cc or,binding
R11273 T13991 T13992 det the,mutants
R11274 T13992 T13994 nsubj mutants,T
R11275 T13993 T13994 compound Tat,T
R11276 T13994 T13983 conj T,binding
R11277 T13995 T13994 punct ",",T
R11319 T14037 T14038 nsubj Tat,associated
R11320 T14038 T14035 ccomp associated,indicated
R11321 T14039 T14038 prep with,associated
R11322 T14040 T14039 pobj p65,with
R11323 T14041 T14040 prep through,p65
R11324 T14042 T14044 det the,domain
R11325 T14043 T14044 compound cysteine-rich,domain
R11326 T14044 T14041 pobj domain,through
R11327 T14045 T14044 cc and,domain
R11328 T14046 T14044 conj ruled-out,domain
R11329 T14047 T14048 det the,requirement
R11330 T14048 T14044 conj requirement,domain
R11331 T14049 T14048 prep of,requirement
R11332 T14050 T14051 amod bridging,proteins
R11333 T14051 T14049 pobj proteins,of
R11334 T14052 T14053 aux to,mediate
R11335 T14053 T14048 acl mediate,requirement
R11336 T14054 T14055 amod such,interaction
R11337 T14055 T14053 dobj interaction,mediate
R11338 T14056 T14035 punct .,indicated
R11397 T14115 T14112 appos 318,p65ΔC
R11398 T14116 T14112 punct ),p65ΔC
R11399 T14117 T14110 punct ",",coimmunoprecipitated
R11400 T14118 T14110 cc and,coimmunoprecipitated
R11401 T14119 T14120 neg not,with
R11402 T14120 T14131 prep with,indicating
R11403 T14121 T14120 pobj p65ΔN,with
R11404 T14122 T14121 punct (,p65ΔN
R11434 T14152 T14149 prep on,effect
R11435 T14153 T14156 det the,affinity
R11436 T14154 T14156 nummod p65,affinity
R11437 T14155 T14156 amod DNA-binding,affinity
R11438 T14156 T14152 pobj affinity,on
R11439 T14157 T14158 punct ",",purified
R11440 T14158 T14161 amod purified,protein
R11468 T14186 T14187 auxpass was,analysed
R11469 T14187 T14187 ROOT analysed,analysed
R11470 T14188 T14187 agent by,analysed
R11471 T14189 T14188 pobj EMSA,by
R11472 T14190 T14187 punct .,analysed
R11473 T14191 T14195 mark Whereas,increased
R11474 T14192 T14193 compound wild-type,Tat
R11475 T14193 T14195 nsubj Tat,increased
R11476 T14194 T14195 advmod significantly,increased
R11477 T14195 T14195 ROOT increased,increased
R11478 T14196 T14197 det the,binding
R11479 T14197 T14195 dobj binding,increased
R11480 T14198 T14197 prep of,binding
R11481 T14199 T14198 pobj p65,of
R11482 T14200 T14195 prep to,increased
R11483 T14201 T14200 pobj DNA,to
R11484 T14202 T14201 punct ",",DNA
R11485 T14203 T14206 det the,C
R11486 T14204 T14206 amod mutant,C
R11487 T14205 T14206 compound Tat,C
R11488 T14206 T14201 appos C,DNA
R11489 T14207 T14206 punct (,C
R11490 T14208 T14206 appos "22,25,27",C
R11534 T14252 T14253 nsubj affinity,binding
R11535 T14253 T14249 ccomp binding,enhanced
R11536 T14254 T14253 prep to,binding
R11537 T14255 T14254 pobj DNA,to
R11538 T14256 T14255 punct (,DNA
R11539 T14257 T14258 compound Figure,4E
R11540 T14258 T14255 appos 4E,DNA
R11541 T14259 T14258 cc and,4E
R11542 T14260 T14258 conj F,4E
R11543 T14261 T14255 punct ),DNA
R14695 T18350 T18351 compound E,−
R14696 T18351 T18352 nummod −,virions
R14697 T18352 T18349 appos virions,−
R14698 T18353 T18352 punct ",",virions
R14699 T18354 T18356 nsubjpass which,used
R14700 T18355 T18356 auxpass were,used
R14701 T18356 T18352 relcl used,virions
R14702 T18357 T18356 prep in,used
R14703 T18358 T18359 amod single-round,infection
R14704 T18359 T18357 pobj infection,in
R14705 T18360 T18359 prep of,infection
R14706 T18361 T18360 pobj U937,of
R14707 T18362 T18361 punct ",",U937
R14708 T18363 T18367 det a,line
R14709 T18364 T18366 amod human,cell
R14710 T18365 T18366 compound monocytic,cell
R14711 T18366 T18367 compound cell,line
R14712 T18367 T18361 appos line,U937
R14713 T18368 T18349 punct .,−
R14714 T18369 T18371 nsubjpass Cells,transfected
R14715 T18370 T18371 auxpass were,transfected
R14716 T18371 T18371 ROOT transfected,transfected
R14717 T18372 T18371 prep with,transfected
R14718 T18373 T18374 compound siRNA,Tat
R14719 T18374 T18372 pobj Tat,with
R14720 T18375 T18371 punct ",",transfected
R14721 T18376 T18377 compound siRNA,control
R14722 T18377 T18379 nsubj control,left
R14723 T18378 T18377 cc or,control
R14724 T18379 T18371 advcl left,transfected
R14725 T18380 T18379 oprd untransfected,left
R14726 T18381 T18382 aux to,modulate
R14727 T18382 T18379 advcl modulate,left
R14728 T18383 T18385 det the,expression
R14729 T18384 T18385 compound Tat,expression
R14730 T18385 T18382 dobj expression,modulate
R14731 T18386 T18379 punct ",",left
R14732 T18387 T18379 cc and,left
R14733 T18388 T18389 advmod then,analysed
R14775 T18430 T18431 amod NF-κB,activity
R14776 T18431 T18441 nsubjpass activity,induced
R14777 T18432 T18431 punct ",",activity
R14778 T18433 T18434 mark as,measured
R14779 T18434 T18431 advcl measured,activity
R14780 T18435 T18434 agent by,measured
R14781 T18436 T18437 nummod p65,DNA
R14782 T18437 T18435 pobj DNA,by
R14783 T18438 T18437 amod binding,DNA
R14784 T18439 T18441 punct ",",induced
R14785 T18440 T18441 auxpass was,induced
R14786 T18441 T18441 ROOT induced,induced
R14787 T18442 T18441 prep at,induced
R14788 T18443 T18444 amod 3-h,post-infection
R14789 T18444 T18442 pobj post-infection,at
R14790 T18445 T18444 prep in,post-infection
R14791 T18446 T18447 det both,Tat-positive
R14792 T18447 T18457 nmod Tat-positive,cells
R14932 T18587 T18585 appos Figure,p65
R14933 T18588 T18587 nummod 6E,Figure
R14934 T18589 T18587 punct ),Figure
R14935 T18590 T18581 punct ",",coimmunoprecipitated
R14936 T18591 T18581 cc and,coimmunoprecipitated
R14937 T18592 T18581 conj activated,coimmunoprecipitated
R14938 T18593 T18595 det the,expression
R14939 T18594 T18595 amod MIP-1α,expression
R14940 T18595 T18592 dobj expression,activated
R14941 T18596 T18592 prep in,activated
R14942 T18597 T18599 det a,manner
R14943 T18598 T18599 amod p65-dependent,manner
R14944 T18599 T18596 pobj manner,in
R14945 T18600 T18592 punct ",",activated
R14946 T18601 T18602 mark as,shown
R14947 T18602 T18592 advcl shown,activated
R14948 T18603 T18602 agent by,shown
R14949 T18604 T18605 det the,lack
R14950 T18605 T18603 pobj lack,by
R14951 T18606 T18605 prep of,lack
R14952 T18607 T18606 pobj effect,of
R14953 T18608 T18605 prep following,lack
R14954 T18609 T18610 compound RNA,interference
R14955 T18610 T18608 pobj interference,following
R14956 T18611 T18610 prep of,interference
R14957 T18612 T18611 pobj Tat,of
R14958 T18613 T18610 cc or,interference
R14959 T18614 T18610 conj p65,interference
R14960 T18615 T18616 punct (,Figure
R14961 T18616 T18605 appos Figure,lack
R14962 T18617 T18616 nummod 6F,Figure
R14963 T18618 T18616 punct ),Figure
R14964 T18619 T18581 punct .,coimmunoprecipitated
R14965 T18620 T18627 advmod Moreover,recruited
R14966 T18621 T18627 punct ",",recruited
R14967 T18622 T18627 nsubjpass Tat,recruited
R14968 T18623 T18622 cc and,Tat
R15010 T18665 T18664 cc and,IκB-α
R15011 T18666 T18664 conj p65,IκB-α
R15012 T18667 T18662 punct ",",associated
R15013 T18668 T18662 cc and,associated
R15014 T18669 T18662 conj induced,associated
R15015 T18670 T18672 det the,activation
R15016 T18671 T18672 amod p65-dependent,activation
R15017 T18672 T18669 dobj activation,induced
R15018 T18673 T18672 prep of,activation
R15019 T18674 T18675 amod MIP-1α,expression
R15020 T18675 T18673 pobj expression,of
R15021 T18676 T18669 prep through,induced
R15022 T18677 T18676 pobj occupancy,through
R15023 T18678 T18677 prep of,occupancy
R15024 T18679 T18681 det the,promoter
R15025 T18680 T18681 amod MIP-1α,promoter
R15026 T18681 T18678 pobj promoter,of
R15027 T18682 T18669 cc and,induced
R15028 T18683 T18669 conj increased,induced
R15029 T18684 T18683 dobj recruitment,increased
R15030 T18685 T18684 prep of,recruitment
R15031 T18686 T18685 pobj p65,of
R15032 T18687 T18654 punct .,indicated
R16931 T21240 T21241 det This,study
R16932 T21241 T21242 nsubj study,reports
R16933 T21242 T21242 ROOT reports,reports
R16934 T21243 T21245 det a,mechanism
R16935 T21244 T21245 amod novel,mechanism
R16936 T21245 T21242 dobj mechanism,reports
R16937 T21246 T21245 prep of,mechanism
R16938 T21247 T21248 amod NF-κB,activation
R16939 T21248 T21246 pobj activation,of
R16940 T21249 T21245 prep by,mechanism
R16941 T21250 T21253 det the,transactivator
R16942 T21251 T21252 compound HIV-1,Tat
R16943 T21252 T21253 compound Tat,transactivator
R16944 T21253 T21249 pobj transactivator,by
R16945 T21254 T21242 punct .,reports
R16988 T21297 T21295 pobj interaction,via
R16989 T21298 T21297 prep with,interaction
R16990 T21299 T21298 pobj IκB-α,with
R16991 T21300 T21299 cc and,IκB-α
R16992 T21301 T21299 conj p65,IκB-α
R16993 T21302 T21287 punct .,investigated
R16994 T21303 T21311 prep To,monitored
R16995 T21304 T21305 det this,end
R16996 T21305 T21303 pobj end,To
R16997 T21306 T21311 punct ",",monitored
R16998 T21307 T21309 det the,activity
R16999 T21308 T21309 compound NF-κB,activity
R17000 T21309 T21311 nsubjpass activity,monitored
R17001 T21310 T21311 auxpass was,monitored
R17002 T21311 T21311 ROOT monitored,monitored
R17003 T21312 T21311 prep in,monitored
R17004 T21313 T21316 amod single,infection
R17005 T21314 T21316 compound round,infection
R17831 T22140 T22141 amod transcriptional,activation
R17794 T22103 T22105 punct ",",activated
R17795 T22104 T22105 nsubj Tat,activated
R17796 T22105 T22105 ROOT activated,activated
R17797 T22106 T22108 det the,expression
R17798 T22107 T22108 compound cytokine,expression
R17799 T22108 T22105 dobj expression,activated
R17800 T22109 T22108 prep by,expression
R17801 T22110 T22109 pcomp binding,by
R17802 T22111 T22110 prep to,binding
R17803 T22112 T22115 det the,loop
R17804 T22113 T22115 amod TAR-like,loop
R17805 T22114 T22115 compound stem,loop
R17806 T22115 T22111 pobj loop,to
R17807 T22116 T22115 prep of,loop
R17939 T22248 T22247 pcomp counteracting,for
R17940 T22249 T22251 det the,production
R17941 T22250 T22251 amod abnormal,production
R17942 T22251 T22248 dobj production,counteracting
R17943 T22252 T22251 prep of,production
R17944 T22253 T22254 amod pro-inflammatory,cytokines
R17945 T22254 T22252 pobj cytokines,of
R17946 T22255 T22254 cc and,cytokines
R17947 T22256 T22254 conj chemokines,cytokines
R17948 T22257 T22254 prep in,cytokines
R17949 T22258 T22259 amod HIV-1,infection
R17950 T22259 T22257 pobj infection,in
R17951 T22260 T22242 punct .,lead
R17952 T22261 T22262 amod NF-κB,inhibitors
R17953 T22262 T22274 nsubj inhibitors,reduced
R17954 T22263 T22262 punct ",",inhibitors
R17955 T22264 T22265 amod such,as
R17956 T22265 T22262 prep as,inhibitors
R17957 T22266 T22265 pobj anti-oxidants,as
R17958 T22267 T22266 punct ",",anti-oxidants
R17959 T22268 T22266 conj proteasome,anti-oxidants
R17960 T22269 T22268 cc and,proteasome
R17961 T22270 T22268 conj IKK,proteasome
R457 T566 T564 dobj recruitment,promoting
R458 T567 T566 prep of,recruitment
R459 T568 T567 pobj p65,of
R460 T569 T564 prep with,promoting
R461 T570 T569 pobj displacement,with
R462 T571 T570 prep of,displacement
R463 T572 T571 pobj IκB-α,of
R464 T573 T577 punct ;,obtained
R2197 T2412 T2411 punct ",",p65
R2209 T2413 T2407 npadvmod RelB,are
R2214 T2414 T2413 cc and,RelB
R2218 T2415 T2413 conj c-Rel,RelB
R2222 T2416 T2417 punct (,2
R2226 T2417 T2413 appos 2,RelB
R2230 T2418 T2417 punct ),2
R2235 T2419 T2397 punct .,depends
R2239 T2420 T2432 nsubj Inhibitors,interfere
R2244 T2421 T2420 prep of,Inhibitors
R2247 T2422 T2421 pobj NF-κB,of
R2254 T2423 T2422 punct (,NF-κB
R2257 T2424 T2422 appos IκB,NF-κB
R2258 T2425 T2422 punct ),NF-κB
R2259 T2426 T2420 appos associate,Inhibitors
R2474 T2729 T2731 aux do,develop
R2476 T2730 T2731 neg not,develop
R2477 T2731 T2724 conj develop,lack
R2478 T2732 T2731 dobj AIDS,develop
R2480 T2733 T2731 prep despite,develop
R2481 T2734 T2736 amod high,replication
R2482 T2735 T2736 compound virus,replication
R2484 T2736 T2733 pobj replication,despite
R2485 T2737 T2736 punct (,replication
R2487 T2738 T2736 appos "28,29",replication
R2488 T2739 T2736 punct ),replication
R2491 T2740 T2709 punct .,hosts
R2606 T2887 T2885 appos 35,Sp1
R2607 T2888 T2885 punct ),Sp1
R2608 T2889 T2885 punct ",",Sp1
R2610 T2890 T2885 conj TFIID,Sp1
R2611 T2891 T2890 punct (,TFIID
R2612 T2892 T2890 appos 36,TFIID
R2614 T2893 T2890 punct ),TFIID
R2615 T2894 T2890 punct ",",TFIID
R2617 T2895 T2890 conj E2F-4,TFIID
R2618 T2896 T2895 punct (,E2F-4
R2620 T2897 T2895 appos 37,E2F-4
R2622 T2898 T2895 punct ),E2F-4
R2623 T2899 T2895 punct ",",E2F-4
R2624 T2900 T2901 compound C/EBP,β
R2626 T2901 T2895 conj β,E2F-4
R2627 T2902 T2901 punct (,β
R2628 T2903 T2901 appos 38,β
R2630 T2904 T2901 punct ),β
R2631 T2905 T2901 punct ",",β
R2632 T2906 T2914 nmod cyclin,acetyltransferases
R2862 T3043 T3040 dobj feedback,subvert
R2863 T3044 T3043 prep of,feedback
R2864 T3045 T3044 pobj NF-κB,of
R2865 T3046 T3045 punct ",",NF-κB
R2866 T3047 T3048 nsubj which,is
R2867 T3048 T3045 relcl is,NF-κB
R2868 T3049 T3050 advmod mainly,dependent
R2869 T3050 T3048 acomp dependent,is
R2870 T3051 T3050 prep on,dependent
R4211 T4657 T4656 punct ",",Program

UBERON-AE

Id Subject Object Predicate Lexical cue
T4890 6782-6787 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T4891 6953-6958 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T5668 8329-8334 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
T6281 10036-10040 http://purl.obolibrary.org/obo/UBERON_0001913 denotes milk
T7505 12593-12604 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensively
T8154 14811-14815 http://purl.obolibrary.org/obo/UBERON_0002415 denotes tail
T8411 18862-18873 http://purl.obolibrary.org/obo/UBERON_2000106 denotes extensively
T15077 33199-33204 http://purl.obolibrary.org/obo/UBERON_0002391 denotes lymph
T15078 33199-33210 http://purl.obolibrary.org/obo/UBERON_0000029 denotes lymph nodes

GO-BP

Id Subject Object Predicate Lexical cue
T633 35-50 http://purl.obolibrary.org/obo/GO_0051092 denotes activates NF-κB
T634 458-473 http://purl.obolibrary.org/obo/GO_0051092 denotes activated NF-κB
T635 1190-1206 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T636 671-686 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T637 1327-1348 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T3164 1396-1409 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3165 1431-1444 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3166 4314-4327 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T3167 4354-4369 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T3168 5034-5049 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T3169 5638-5653 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T3170 1490-1511 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T3171 3372-3384 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T3172 2022-2038 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T3173 3107-3126 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T3174 3865-3893 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activity by activation
T3175 2066-2069 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T3176 2319-2322 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T3177 3897-3900 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T3178 4956-4959 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T3179 2134-2159 http://purl.obolibrary.org/obo/GO_0016567 denotes protein to ubiquitination
T3180 2176-2187 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T3181 4985-4996 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T3182 2274-2292 http://purl.obolibrary.org/obo/GO_0032088 denotes inhibitor of NF-κB
T3183 2274-2292 http://purl.obolibrary.org/obo/GO_0007252 denotes inhibitor of NF-κB
T3184 2473-2488 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T3185 2509-2512 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T3186 2539-2543 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCζ
T3187 2861-2884 http://purl.obolibrary.org/obo/GO_0006355 denotes transcriptional control
T3188 3316-3329 http://purl.obolibrary.org/obo/GO_0007155 denotes cell adhesion
T3189 3316-3339 http://purl.obolibrary.org/obo/GO_0060352 denotes cell adhesion molecules
T3190 3776-3788 http://purl.obolibrary.org/obo/GO_0009405 denotes pathogenesis
T3191 4060-4077 http://purl.obolibrary.org/obo/GO_0019058 denotes viral replication
T3192 4060-4077 http://purl.obolibrary.org/obo/GO_0019079 denotes viral replication
T3193 4184-4199 http://purl.obolibrary.org/obo/GO_2000144 denotes transactivation
T3194 4237-4245 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T3195 4237-4245 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T3196 4237-4245 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T3197 4237-4245 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T3198 4506-4512 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T3199 4658-4667 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T3200 5205-5214 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T3201 4926-4938 http://purl.obolibrary.org/obo/GO_0009293 denotes transduction
T3202 5199-5214 http://purl.obolibrary.org/obo/GO_0038061 denotes NF-κB signaling
T3203 5331-5340 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T3204 5420-5434 http://purl.obolibrary.org/obo/GO_0051168 denotes nuclear export
T5503 7269-7271 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T5504 7962-7964 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T5505 7434-7442 http://purl.obolibrary.org/obo/GO_0001906 denotes necrosis
T5506 7434-7442 http://purl.obolibrary.org/obo/GO_0008219 denotes necrosis
T5507 7434-7442 http://purl.obolibrary.org/obo/GO_0019835 denotes necrosis
T5508 7728-7733 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T5509 7434-7442 http://purl.obolibrary.org/obo/GO_0070265 denotes necrosis
T5510 7823-7849 http://purl.obolibrary.org/obo/GO_0004565 denotes β-galactosidase activities
T5511 8004-8031 http://purl.obolibrary.org/obo/GO_0004565 denotes activity to β-galactosidase
T5512 7823-7849 http://purl.obolibrary.org/obo/GO_0004336 denotes β-galactosidase activities
T5513 8004-8031 http://purl.obolibrary.org/obo/GO_0004336 denotes activity to β-galactosidase
T5514 7823-7849 http://purl.obolibrary.org/obo/GO_1903771 denotes β-galactosidase activities
T5515 8004-8031 http://purl.obolibrary.org/obo/GO_1903771 denotes activity to β-galactosidase
T5516 7823-7849 http://purl.obolibrary.org/obo/GO_1903770 denotes β-galactosidase activities
T5517 8004-8031 http://purl.obolibrary.org/obo/GO_1903770 denotes activity to β-galactosidase
T5518 7823-7849 http://purl.obolibrary.org/obo/GO_0033920 denotes β-galactosidase activities
T5519 8004-8031 http://purl.obolibrary.org/obo/GO_0033920 denotes activity to β-galactosidase
T5520 7823-7849 http://purl.obolibrary.org/obo/GO_0033929 denotes β-galactosidase activities
T5521 8004-8031 http://purl.obolibrary.org/obo/GO_0033929 denotes activity to β-galactosidase
T5522 7823-7849 http://purl.obolibrary.org/obo/GO_0033930 denotes β-galactosidase activities
T5523 8004-8031 http://purl.obolibrary.org/obo/GO_0033930 denotes activity to β-galactosidase
T5524 7993-8012 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T5525 7993-8012 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T5526 7993-8012 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T5527 7993-8012 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T5528 7993-8012 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T5972 8081-8097 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T5973 8507-8523 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T5974 8727-8743 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T5975 8214-8216 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T6618 9354-9357 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T6619 10478-10481 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T6620 10544-10547 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T6621 10234-10236 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T6622 10721-10734 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T6811 10942-10953 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T6812 11079-11090 http://purl.obolibrary.org/obo/GO_0006412 denotes translation
T6813 11065-11078 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T7397 11612-11625 http://purl.obolibrary.org/obo/GO_0003899 denotes Transcriptase
T7398 11612-11625 http://purl.obolibrary.org/obo/GO_0003968 denotes Transcriptase
T7399 11612-11625 http://purl.obolibrary.org/obo/GO_0034062 denotes Transcriptase
T7400 12099-12108 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T7401 12099-12116 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling pathway
T7402 12191-12206 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T8080 12677-12682 http://purl.obolibrary.org/obo/GO_0019835 denotes lysis
T10407 15122-15138 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10408 18426-18442 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10409 18917-18933 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T10410 15212-15228 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T10411 16006-16021 http://purl.obolibrary.org/obo/GO_2000144 denotes transactivation
T10412 17749-17757 http://purl.obolibrary.org/obo/GO_0009056 denotes degraded
T10413 18156-18167 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T10414 18498-18509 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T10415 17961-17964 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10416 18131-18134 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10417 18473-18476 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10418 18619-18622 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10419 19932-19935 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10420 20165-20168 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10421 18171-18180 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T10422 18640-18649 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T10423 19797-19806 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T10424 22162-22171 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T10425 18309-18322 http://purl.obolibrary.org/obo/GO_0003899 denotes transcriptase
T10426 18309-18322 http://purl.obolibrary.org/obo/GO_0003968 denotes transcriptase
T10427 18309-18322 http://purl.obolibrary.org/obo/GO_0034062 denotes transcriptase
T10428 18719-18741 http://purl.obolibrary.org/obo/GO_0004704 denotes NF-κB activity induced
T10429 19789-19806 http://purl.obolibrary.org/obo/GO_0006189 denotes de novo synthesis
T10430 22154-22171 http://purl.obolibrary.org/obo/GO_0006189 denotes de novo synthesis
T10431 19789-19806 http://purl.obolibrary.org/obo/GO_0097294 denotes de novo synthesis
T10432 22154-22171 http://purl.obolibrary.org/obo/GO_0097294 denotes de novo synthesis
T12463 22657-22667 http://purl.obolibrary.org/obo/GO_0006412 denotes translated
T12464 22657-22676 http://purl.obolibrary.org/obo/GO_0006412 denotes translated proteins
T12465 25920-25935 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T12466 26363-26378 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T14263 27014-27033 http://purl.obolibrary.org/obo/GO_0006412 denotes translated proteins
T14264 29247-29262 http://purl.obolibrary.org/obo/GO_2000144 denotes transactivation
T16611 30768-30783 http://purl.obolibrary.org/obo/GO_2000144 denotes transactivation
T16612 30895-30910 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T16613 33336-33351 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T16614 30895-30934 http://purl.obolibrary.org/obo/GO_1900622 denotes transcriptional activation was mediated
T16615 31258-31268 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T16616 33352-33362 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T16617 33918-33933 http://purl.obolibrary.org/obo/GO_1904469 denotes TNF-α activated
T16618 34408-34423 http://purl.obolibrary.org/obo/GO_0034612 denotes response to TNF
T16619 34750-34766 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T16620 35017-35033 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T18688 35177-35192 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T18689 35681-35697 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T18690 38695-38711 http://purl.obolibrary.org/obo/GO_0051092 denotes NF-κB activation
T18691 35708-35723 http://purl.obolibrary.org/obo/GO_0016032 denotes viral infection
T18692 38445-38454 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T18693 38537-38540 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T18694 39093-39109 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T22326 39672-39687 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T22327 43380-43395 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T22328 44687-44702 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T22329 44987-45002 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T22330 45069-45084 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T22331 45331-45346 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T22332 45430-45443 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T22333 39844-39858 http://purl.obolibrary.org/obo/GO_0051092 denotes activate NF-κB
T22334 40886-40905 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T22335 42043-42062 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T22336 46092-46107 http://purl.obolibrary.org/obo/GO_0051092 denotes activates NF-κB
T22337 39986-40002 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T22338 42439-42455 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T22339 40083-40109 http://purl.obolibrary.org/obo/GO_1901224 denotes NF-κB activation signaling
T22340 40100-40109 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T22341 40264-40267 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T22342 40351-40354 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T22343 40629-40632 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T22344 45860-45863 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T22345 40289-40300 http://purl.obolibrary.org/obo/GO_0009056 denotes degradation
T22346 40372-40381 http://purl.obolibrary.org/obo/GO_0009058 denotes synthesis
T22347 41889-41899 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T22348 43154-43164 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T22349 43441-43451 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T22350 43351-43370 http://purl.obolibrary.org/obo/GO_0016573 denotes histone acetylation
T22351 43546-43561 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T22352 44687-44710 http://purl.obolibrary.org/obo/GO_0006355 denotes transcriptional control
T22353 45059-45095 http://purl.obolibrary.org/obo/GO_1900622 denotes dependent transcriptional activation
T22354 45059-45095 http://purl.obolibrary.org/obo/GO_0045893 denotes dependent transcriptional activation
T22355 45804-45820 http://purl.obolibrary.org/obo/GO_0032088 denotes NF-κB inhibitors
T22356 45985-46001 http://purl.obolibrary.org/obo/GO_0032088 denotes NF-κB inhibitors
T22357 45804-45820 http://purl.obolibrary.org/obo/GO_0007252 denotes NF-κB inhibitors
T22358 45985-46001 http://purl.obolibrary.org/obo/GO_0007252 denotes NF-κB inhibitors
T22359 45939-45960 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammatory response
T24183 16457-16476 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T24184 16457-16476 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T24185 16457-16476 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T24186 16457-16476 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T24187 16457-16476 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T24188 16646-16659 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T24189 17089-17092 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T24190 17162-17165 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T24996 20760-20773 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T24997 21109-21112 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T24998 21182-21185 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T26107 23690-23700 http://purl.obolibrary.org/obo/GO_0006412 denotes translated
T26108 23979-23989 http://purl.obolibrary.org/obo/GO_0006412 denotes translated
T26109 23690-23709 http://purl.obolibrary.org/obo/GO_0006412 denotes translated proteins
T26110 24455-24474 http://purl.obolibrary.org/obo/GO_0006412 denotes translated proteins
T26111 25078-25097 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T26112 25078-25097 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T26113 25078-25097 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T26114 25078-25097 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T26115 25078-25097 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T26116 25169-25193 http://purl.obolibrary.org/obo/GO_0004565 denotes β-galactosidase activity
T26117 25169-25193 http://purl.obolibrary.org/obo/GO_0004336 denotes β-galactosidase activity
T26118 25169-25193 http://purl.obolibrary.org/obo/GO_1903771 denotes β-galactosidase activity
T26119 25169-25193 http://purl.obolibrary.org/obo/GO_1903770 denotes β-galactosidase activity
T26120 25169-25193 http://purl.obolibrary.org/obo/GO_0033920 denotes β-galactosidase activity
T26121 25169-25193 http://purl.obolibrary.org/obo/GO_0033929 denotes β-galactosidase activity
T26122 25169-25193 http://purl.obolibrary.org/obo/GO_0033930 denotes β-galactosidase activity
T26938 27845-27855 http://purl.obolibrary.org/obo/GO_0006412 denotes translated
T26939 28799-28809 http://purl.obolibrary.org/obo/GO_0006412 denotes translated
T26940 28679-28681 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T27981 31690-31706 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T28825 36480-36493 http://purl.obolibrary.org/obo/GO_0006351 denotes Transcription
T28826 36755-36758 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T28827 36830-36833 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T29273 43648-43663 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T29274 43795-43810 http://purl.obolibrary.org/obo/GO_0006351 denotes transcriptional
T29275 43859-43872 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription

GO-MF

Id Subject Object Predicate Lexical cue
T640 539-546 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T641 650-657 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T642 539-559 http://purl.obolibrary.org/obo/GO_0051059 denotes binding to the NF-κB
T643 646-657 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA-binding
T3224 1686-1697 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA-binding
T3225 1974-1988 http://purl.obolibrary.org/obo/GO_0003677 denotes binding to DNA
T3226 2630-2641 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T3227 5622-5633 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T3228 1690-1697 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T3229 1974-1981 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T3230 2634-2641 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T3231 3810-3817 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T3232 4671-4678 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T3233 5626-5633 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T3234 2066-2069 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T3235 2319-2322 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T3236 3897-3900 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T3237 4956-4959 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T3238 2509-2512 http://purl.obolibrary.org/obo/GO_0004691 denotes PKA
T3239 2539-2543 http://purl.obolibrary.org/obo/GO_0004697 denotes PKCζ
T3240 2913-2922 http://purl.obolibrary.org/obo/GO_0031386 denotes ubiquitin
T3241 4283-4288 http://purl.obolibrary.org/obo/GO_0005138 denotes 6 (IL
T3242 4506-4512 http://purl.obolibrary.org/obo/GO_0016538 denotes cyclin
T3243 4569-4572 http://purl.obolibrary.org/obo/GO_0008140 denotes CBP
T5529 7269-7271 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T5530 7962-7964 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T5531 7823-7849 http://purl.obolibrary.org/obo/GO_0004565 denotes β-galactosidase activities
T5532 8004-8031 http://purl.obolibrary.org/obo/GO_0004565 denotes activity to β-galactosidase
T5533 7823-7849 http://purl.obolibrary.org/obo/GO_0004336 denotes β-galactosidase activities
T5534 8004-8031 http://purl.obolibrary.org/obo/GO_0004336 denotes activity to β-galactosidase
T5535 7823-7849 http://purl.obolibrary.org/obo/GO_0033920 denotes β-galactosidase activities
T5536 8004-8031 http://purl.obolibrary.org/obo/GO_0033920 denotes activity to β-galactosidase
T5537 7823-7849 http://purl.obolibrary.org/obo/GO_0033929 denotes β-galactosidase activities
T5538 8004-8031 http://purl.obolibrary.org/obo/GO_0033929 denotes activity to β-galactosidase
T5539 7823-7849 http://purl.obolibrary.org/obo/GO_0033930 denotes β-galactosidase activities
T5540 8004-8031 http://purl.obolibrary.org/obo/GO_0033930 denotes activity to β-galactosidase
T5541 7993-8012 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T5542 7993-8012 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T5543 7993-8012 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T5544 7993-8012 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T5545 7993-8012 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T5976 8214-8216 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T6238 9130-9138 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T6623 9354-9357 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T6624 10478-10481 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T6625 10544-10547 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T6626 9377-9388 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T6627 9381-9388 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T6628 10612-10619 http://purl.obolibrary.org/obo/GO_0005488 denotes Binding
T6629 9833-9843 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T6630 10164-10174 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T6631 10234-10236 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T7403 11612-11625 http://purl.obolibrary.org/obo/GO_0003899 denotes Transcriptase
T7404 11612-11625 http://purl.obolibrary.org/obo/GO_0003968 denotes Transcriptase
T7405 11612-11625 http://purl.obolibrary.org/obo/GO_0034062 denotes Transcriptase
T8081 13304-13314 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T8082 13354-13364 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T10460 17312-17319 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10461 17579-17586 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10462 18979-18986 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10463 19199-19206 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10464 19346-19353 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10465 19575-19582 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10466 22479-22486 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T10467 17312-17331 http://purl.obolibrary.org/obo/GO_0051059 denotes binding to an NF-κB
T10468 17575-17586 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T10469 18975-18986 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T10470 19195-19206 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T10471 19342-19353 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T10472 17961-17964 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10473 18131-18134 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10474 18473-18476 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10475 18619-18622 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10476 19932-19935 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10477 20165-20168 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T10478 18309-18322 http://purl.obolibrary.org/obo/GO_0003899 denotes transcriptase
T10479 18309-18322 http://purl.obolibrary.org/obo/GO_0003968 denotes transcriptase
T10480 18309-18322 http://purl.obolibrary.org/obo/GO_0034062 denotes transcriptase
T10481 18719-18741 http://purl.obolibrary.org/obo/GO_0004704 denotes NF-κB activity induced
T12467 22567-22574 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12468 23027-23034 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12469 23152-23159 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12470 23265-23272 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12471 23342-23349 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12472 25565-25572 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12473 25718-25725 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12474 26351-26358 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12475 26442-26449 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T12476 25565-25579 http://purl.obolibrary.org/obo/GO_0003677 denotes binding to DNA
T12477 25714-25725 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T12478 26347-26358 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA-binding
T14265 26490-26497 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14266 27052-27059 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14267 27162-27169 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14268 29133-29140 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14269 29542-29549 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14270 29735-29742 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14271 29815-29822 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14272 29879-29886 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14273 29938-29945 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14274 30110-30117 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T14275 26490-26504 http://purl.obolibrary.org/obo/GO_0003677 denotes binding to DNA
T14276 29938-29952 http://purl.obolibrary.org/obo/GO_0003677 denotes binding to DNA
T14277 30110-30124 http://purl.obolibrary.org/obo/GO_0003677 denotes binding to DNA
T16621 33696-33709 http://purl.obolibrary.org/obo/GO_0051059 denotes NF-κB binding
T16622 33702-33709 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T16623 34728-34735 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18696 38165-38176 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T18697 38169-38176 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T18698 38537-38540 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T22364 40264-40267 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T22365 40351-40354 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T22366 40629-40632 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T22367 45860-45863 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T22368 41087-41094 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22369 41245-41252 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22370 41367-41374 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22371 41580-41587 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22372 41714-41721 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22373 42003-42010 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22374 42538-42545 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22375 42666-42673 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22376 42730-42737 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22377 44905-44912 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22378 41580-41598 http://purl.obolibrary.org/obo/GO_0044197 denotes binding to the RHD
T22379 42003-42017 http://purl.obolibrary.org/obo/GO_0003677 denotes binding to DNA
T22380 42726-42737 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T22381 42538-42558 http://purl.obolibrary.org/obo/GO_0051059 denotes binding to the NF-κB
T22382 44781-44785 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T22383 44858-44862 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6
T24191 16457-16476 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T24192 16457-16476 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T24193 16457-16476 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T24194 16457-16476 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T24195 16457-16476 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T24196 16577-16584 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T24197 16577-16597 http://purl.obolibrary.org/obo/GO_0051059 denotes binding to the NF-κB
T24198 16850-16860 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T24199 16919-16929 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T24200 17089-17092 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T24201 17162-17165 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T24999 20691-20698 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T25000 20691-20711 http://purl.obolibrary.org/obo/GO_0051059 denotes binding to the NF-κB
T25001 20996-21006 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T25002 21667-21677 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T25003 21109-21112 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T25004 21182-21185 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T26123 23784-23792 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T26124 24126-24134 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T26125 24243-24253 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T26126 25472-25482 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T26127 24398-24409 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T26128 24662-24673 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA binding
T26129 24402-24409 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T26130 24666-24673 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T26131 25078-25097 http://purl.obolibrary.org/obo/GO_0045289 denotes luciferase activity
T26132 25078-25097 http://purl.obolibrary.org/obo/GO_0047077 denotes luciferase activity
T26133 25078-25097 http://purl.obolibrary.org/obo/GO_0047712 denotes luciferase activity
T26134 25078-25097 http://purl.obolibrary.org/obo/GO_0050248 denotes luciferase activity
T26135 25078-25097 http://purl.obolibrary.org/obo/GO_0050397 denotes luciferase activity
T26136 25169-25193 http://purl.obolibrary.org/obo/GO_0004565 denotes β-galactosidase activity
T26137 25169-25193 http://purl.obolibrary.org/obo/GO_0004336 denotes β-galactosidase activity
T26138 25169-25193 http://purl.obolibrary.org/obo/GO_0033920 denotes β-galactosidase activity
T26139 25169-25193 http://purl.obolibrary.org/obo/GO_0033929 denotes β-galactosidase activity
T26140 25169-25193 http://purl.obolibrary.org/obo/GO_0033930 denotes β-galactosidase activity
T26941 27431-27438 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T26942 27704-27712 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T26943 28491-28499 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T26944 28607-28617 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T26945 28679-28681 http://purl.obolibrary.org/obo/GO_0033968 denotes CA
T27982 32141-32149 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T27983 32426-32434 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T27984 32706-32714 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T28828 36363-36370 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T28829 36646-36654 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T28830 37107-37115 http://purl.obolibrary.org/obo/GO_0003823 denotes antibody
T28831 37237-37247 http://purl.obolibrary.org/obo/GO_0003823 denotes antibodies
T28832 36755-36758 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T28833 36830-36833 http://purl.obolibrary.org/obo/GO_0008384 denotes IKK
T29277 43993-44000 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T644 554-567 http://purl.obolibrary.org/obo/GO_0071159 denotes NF-κB complex
T3205 1735-1748 http://purl.obolibrary.org/obo/GO_0071159 denotes NF-κB complex
T3206 1937-1950 http://purl.obolibrary.org/obo/GO_0071159 denotes NF-κB complex
T3207 2219-2232 http://purl.obolibrary.org/obo/GO_0071159 denotes NF-κB complex
T3208 5670-5683 http://purl.obolibrary.org/obo/GO_0071159 denotes NF-κB complex
T3209 2240-2247 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T3210 2423-2433 http://purl.obolibrary.org/obo/GO_0000502 denotes proteasome
T3211 2509-2512 http://purl.obolibrary.org/obo/GO_0005952 denotes PKA
T3212 3316-3320 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3213 4032-4036 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3214 4653-4657 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3215 4682-4686 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T3216 4840-4845 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T3217 3484-3489 http://purl.obolibrary.org/obo/GO_0018995 denotes hosts
T3218 4027-4031 http://purl.obolibrary.org/obo/GO_0018995 denotes host
T3219 3831-3845 http://purl.obolibrary.org/obo/GO_0019031 denotes viral envelope
T3220 3837-3845 http://purl.obolibrary.org/obo/GO_0009274 denotes envelope
T3221 4027-4036 http://purl.obolibrary.org/obo/GO_0043657 denotes host cell
T5546 6683-6688 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5547 6755-6760 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5548 6800-6805 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5549 7307-7312 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5550 7708-7713 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6239 8855-8862 http://purl.obolibrary.org/obo/GO_0019012 denotes virions
T6240 9248-9255 http://purl.obolibrary.org/obo/GO_0019012 denotes virions
T6241 8895-8900 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6242 9192-9197 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6243 9130-9138 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T6632 9321-9325 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T6633 10566-10570 http://purl.obolibrary.org/obo/GO_0005623 denotes Cell
T6634 9767-9775 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane
T6635 9833-9843 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T6636 10164-10174 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T6637 9833-9843 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T6638 10164-10174 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T7406 11460-11465 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10433 15237-15242 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10434 15329-15334 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10435 15437-15442 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10436 15677-15682 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10437 15738-15743 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10438 15904-15909 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10439 15965-15970 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10440 17527-17532 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10441 17915-17920 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10442 18768-18773 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10443 18960-18965 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10444 19431-19436 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10445 19467-19472 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10446 19561-19566 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10447 19886-19891 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10448 20137-20142 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10449 22298-22303 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10450 22363-22368 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T10451 15390-15397 http://purl.obolibrary.org/obo/GO_0019012 denotes virions
T10452 17398-17405 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T10453 19027-19034 http://purl.obolibrary.org/obo/GO_0005634 denotes nucleus
T10454 17765-17772 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosol
T10455 17933-17940 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosol
T10456 19134-19141 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosol
T10457 19904-19911 http://purl.obolibrary.org/obo/GO_0005829 denotes cytosol
T10458 19689-19702 http://purl.obolibrary.org/obo/GO_0071159 denotes NF-κB complex
T10459 21953-21966 http://purl.obolibrary.org/obo/GO_0071159 denotes NF-κB complex
T14278 26593-26598 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T14279 29154-29159 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16624 30402-30407 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16625 30832-30837 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16626 33104-33109 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16627 33189-33194 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16628 33759-33764 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T16629 34874-34883 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T18699 35448-35455 http://purl.obolibrary.org/obo/GO_0019012 denotes virions
T18700 35526-35530 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T18701 35852-35857 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18702 38279-38284 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18703 38341-38346 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18704 38754-38759 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T18705 38906-38911 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22360 40153-40157 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T22361 40763-40768 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22362 46063-46068 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T22363 45845-45855 http://purl.obolibrary.org/obo/GO_0000502 denotes proteasome
T24202 16156-16161 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24203 16266-16271 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24204 16499-16503 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T24205 16323-16330 http://purl.obolibrary.org/obo/GO_0019012 denotes virions
T24206 16850-16860 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T24207 16919-16929 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T24208 16850-16860 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T24209 16919-16929 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T26141 23784-23792 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T26142 24126-24134 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T26143 24243-24253 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T26144 25472-25482 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T26145 23784-23792 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T26146 24126-24134 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T26147 24243-24253 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T26148 25472-25482 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T26149 24778-24799 http://purl.obolibrary.org/obo/GO_0001114 denotes DNA/protein complexes
T26150 24778-24799 http://purl.obolibrary.org/obo/GO_0032993 denotes DNA/protein complexes
T26151 24778-24799 http://purl.obolibrary.org/obo/GO_0097522 denotes DNA/protein complexes
T26152 24782-24799 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complexes
T26153 24887-24892 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T26154 25114-25118 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T26155 25363-25367 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T26946 27449-27454 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T26947 28254-28259 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T26948 27704-27712 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T26949 28491-28499 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T26950 28607-28617 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T26951 27704-27712 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T26952 28491-28499 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T26953 28607-28617 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T26954 28029-28046 http://purl.obolibrary.org/obo/GO_0043234 denotes Protein complexes
T26955 28952-28969 http://purl.obolibrary.org/obo/GO_0043234 denotes protein complexes
T26956 28948-28969 http://purl.obolibrary.org/obo/GO_0001114 denotes DNA/protein complexes
T26957 28948-28969 http://purl.obolibrary.org/obo/GO_0032993 denotes DNA/protein complexes
T26958 28948-28969 http://purl.obolibrary.org/obo/GO_0097522 denotes DNA/protein complexes
T27972 32018-32023 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T27973 32239-32244 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T27974 32524-32529 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T27975 32141-32149 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T27976 32426-32434 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T27977 32706-32714 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T27978 32141-32149 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T27979 32426-32434 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T27980 32706-32714 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T28834 36008-36013 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T28835 36115-36120 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T28836 36885-36890 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T28837 37258-37263 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T28838 37377-37382 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T28839 37579-37584 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T28840 37689-37694 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T28841 36177-36184 http://purl.obolibrary.org/obo/GO_0019012 denotes virions
T28842 36957-36964 http://purl.obolibrary.org/obo/GO_0019012 denotes virions
T28843 37439-37446 http://purl.obolibrary.org/obo/GO_0019012 denotes virions
T28844 37751-37758 http://purl.obolibrary.org/obo/GO_0019012 denotes virions
T28845 36646-36654 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T28846 37107-37115 http://purl.obolibrary.org/obo/GO_0019815 denotes antibody
T28847 37237-37247 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T28848 36646-36654 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T28849 37107-37115 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T28850 37237-37247 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T29276 44008-44021 http://purl.obolibrary.org/obo/GO_0071159 denotes NF-κB complex
T5969 8113-8118 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5970 8251-8256 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T5971 8456-8461 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T6237 9130-9138 http://purl.obolibrary.org/obo/GO_0042571 denotes antibody
T8072 12365-12374 http://purl.obolibrary.org/obo/GO_0000785 denotes Chromatin
T8073 12930-12939 http://purl.obolibrary.org/obo/GO_0000785 denotes Chromatin
T8074 14206-14215 http://purl.obolibrary.org/obo/GO_0000785 denotes chromatin
T8075 12650-12655 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T8076 13304-13314 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T8077 13354-13364 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T8078 13304-13314 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T8079 13354-13364 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T24988 20336-20341 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24989 21237-21242 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24990 21318-21323 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T24991 21448-21452 http://purl.obolibrary.org/obo/GO_0005623 denotes cell
T24992 20996-21006 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T24993 21667-21677 http://purl.obolibrary.org/obo/GO_0019815 denotes antibodies
T24994 20996-21006 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T24995 21667-21677 http://purl.obolibrary.org/obo/GO_0042571 denotes antibodies
T27970 31560-31565 http://purl.obolibrary.org/obo/GO_0005623 denotes cells
T27971 31708-31713 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T89 0-94 Sentence denotes Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65
T90 106-248 Sentence denotes Nuclear factor (NF)-κB is a master regulator of pro-inflammatory genes and is upregulated in human immunodeficiency virus 1 (HIV-1) infection.
T91 249-347 Sentence denotes Mechanisms underlying the NF-κB deregulation by HIV-1 are relevant for immune dysfunction in AIDS.
T92 348-568 Sentence denotes We report that in single round HIV-1 infection, or single-pulse PMA stimulation, the HIV-1 Tat transactivator activated NF-κB by hijacking the inhibitor IκB-α and by preventing the repressor binding to the NF-κB complex.
T93 569-696 Sentence denotes Moreover, Tat associated with the p65 subunit of NF-κB and increased the p65 DNA-binding affinity and transcriptional activity.
T94 697-841 Sentence denotes The arginine- and cysteine-rich domains of Tat were required for IκB-α and p65 association, respectively, and for sustaining the NF-κB activity.
T95 842-1148 Sentence denotes Among an array of NF-κB-responsive genes, Tat mostly activated the MIP-1α expression in a p65-dependent manner, and bound to the MIP-1α NF-κB enhancer thus promoting the recruitment of p65 with displacement of IκB-α; similar findings were obtained for the NF-κB-responsive genes CSF3, LTA, NFKBIA and TLR2.
T96 1149-1358 Sentence denotes Our results support a novel mechanism of NF-κB activation via physical interaction of Tat with IκB-α and p65, and may contribute to further insights into the deregulation of the inflammatory response by HIV-1.
T1429 1373-1516 Sentence denotes Nuclear factor (NF)-κB transcription factors regulate the transcription of genes that are involved in the immune and inflammatory response (1).
T1430 1517-1698 Sentence denotes The NF-κB family includes RelA/p65, c-Rel, RelB, p50 and p52 that share a highly conserved 300-amino acid Rel homology domain (RHD) for homo- or hetero-dimerization and DNA-binding.
T1431 1699-1891 Sentence denotes The transcriptional activity of the NF-κB complex depends on dimer composition since C-terminal unrelated transcriptional activation domains are present exclusively in p65, RelB and c-Rel (2).
T1432 1892-1993 Sentence denotes Inhibitors of NF-κB (IκB) associate with the NF-κB complex and interfere with its binding to DNA (3).
T1433 1994-2248 Sentence denotes In the canonical pathway of NF-κB activation, the activated IκB kinase (IKK) phosphorylates IκB at specific serine residues that target the protein to ubiquitination and proteasomal degradation, which releases the functional NF-κB complex in the nucleus.
T1434 2249-2438 Sentence denotes IκB-α, the most abundant inhibitor of NF-κB (4), is phosphorylated by IKK at Ser32 and Ser36 (5), and subsequently ubiquitylated at Lys21 and Lys22 to be degraded by the 26S proteasome (6).
T1435 2439-2575 Sentence denotes The NF-κB activity is enhanced by phosphorylation of p65 at Ser276 by PKA and MSK1 (7,8), Ser311 by PKCζ (9) and Ser536 by IKKα (10,11).
T1436 2576-2758 Sentence denotes Acetylation of p65 at Lys218 and Lys221 increases the DNA binding and impairs the association with IκB-α, and acetylation at Lys310 enhances the p65 transcriptional activity (12,13).
T1437 2759-2951 Sentence denotes Post-activation turn off of NF-κB is regulated by negative feedback loop through inhibitors under the transcriptional control of NF-κB, such as IκB-α and ubiquitin-editing protein A20 (14–20).
T1438 2952-3095 Sentence denotes Deacetylation of p65 by histone deacetylase-3 or SIRT1, or acetylation of p65 at Lys122 and Lys123 down-regulate the NF-κB activity (12,21,22).
T1439 3096-3363 Sentence denotes Persistent activation of NF-κB occurs in human immunodeficiency virus-1 (HIV-1)-infected monocytes, macrophages and microglia, and enhances the expression of NF-κB-responsive genes, including pro-inflammatory cytokines, cell adhesion molecules and chemokines (23–25).
T1440 3364-3451 Sentence denotes Chronic inflammation is a major cause of immune and neuron dysfunction in AIDS (26,27).
T1441 3452-3670 Sentence denotes Consistently, non-human primate hosts for simian immunodeficiency virus, such as African green monkeys and sooty mangabey, lack aberrant immune activation and do not develop AIDS despite high virus replication (28,29).
T1442 3671-3789 Sentence denotes Thus, understanding the mechanisms of NF-κB deregulation by HIV-1 may provide further insights into AIDS pathogenesis.
T1443 3790-3928 Sentence denotes In HIV-1 entry, the binding of the gp120 viral envelope to CD4 induces the NF-κB activity by activation of IKK (30) and procaspase 8 (31).
T1444 3929-4078 Sentence denotes Following viral integration, the early encoded HIV-1 Tat protein interacts with the HIV-1 RNA and host cell factors to sustain the viral replication.
T1445 4079-4328 Sentence denotes Tat binds to RNA stem-loop structures generated by the 5′ end of target transcripts, including the HIV-1 transactivation-responsive element (TAR) (32), tumor necrosis factor β (TNFβ) (33) and interleukin-6 (IL-6) (34) to activate gene transcription.
T1446 4329-4591 Sentence denotes Indeed, Tat promotes the transcriptional initiation and elongation by interacting with transacting factors and cofactors, such as Sp1 (35), TFIID (36), E2F-4 (37), C/EBPβ (38), cyclin T1/CDK9 (39,40) and the histone acetyltransferases p300/CBP and P/CAF (41–43).
T1447 4592-4774 Sentence denotes When released from HIV-1-infected cells, Tat deregulates the cell signaling by binding to cell receptors, such as integrins (44), Flk1/KDR receptor (45) and chemokine receptors (46).
T1448 4775-4886 Sentence denotes We first reported that NF-κB was constitutively active in Jurkat cells that stably expressed the Tat gene (47).
T1449 4887-5126 Sentence denotes Following gene transfection or protein transduction, Tat induced the IKK activity and proteasomal degradation of IκB-α (48), and increased the p65 transcriptional activity by inhibiting the SIRT-1-mediated deacetylation of p65 Lys310 (49).
T1450 5127-5358 Sentence denotes These findings suggested that Tat modulates crucial enzymes involved in NF-κB signaling; however, it was unclear how Tat could subvert the negative feedback of NF-κB, which is mainly dependent on de novo synthesis of IκB-α (15,17).
T1451 5359-5471 Sentence denotes We previously found that IκB-α binds to Tat and promotes the nuclear export of the viral transactivator (50,51).
T1452 5472-5684 Sentence denotes In this study, we report that Tat counteracts the post-activation turn off of NF-κB through direct interaction with IκB-α and p65, which enhances the DNA binding and transcriptional activity of the NF-κB complex.
T1453 5685-5823 Sentence denotes The new mechanism of NF-κB deregulation here described may provide further insights into the chronic immune activation of HIV-1 infection.
T4409 5848-5856 Sentence denotes Plasmids
T4410 5857-6081 Sentence denotes The plasmids pcDNA-3xHA-IκB-α, p3xFLAG-CMV-Tat, p3xFLAG-CMV-Tat C(22,25,27)A, p3xFLAG-CMV-Tat R(49,52,53,55,56,57)A, pGEX-2T-Tat, pGEX-2T-Tat C(22,25,27)A and pGEX-2T-Tat R(49,52,53,55,56,57)A were previously described (50).
T4411 6082-6294 Sentence denotes The plasmids pNL4-3.Luc.R-E- and pHXB2-env were obtained from the AIDS Research & Reference Reagent Program, Division of AIDS, NIAID, NIH, USA; pκBluc and pSV-β-Gal were purchased from Promega (Madison, WI, USA).
T4412 6295-6560 Sentence denotes The plasmids pRc/CMV-3xHA-p65, pRc/CMV-3xHA-p65ΔC(1–318), pRc/CMV-3xHA-p65ΔN(122–551), p3xFLAG-CMV-Tat T,N(23,24)A, p3xFLAG-CMV-Tat K(50,51)A, pGEX-2T-Tat T,N(23,24)A, pGEX-2T-Tat K(50,51)A and pNL4-3.FLAG-Tat.R-E- were generated as described in Supplementary Data.
T4906 6562-6614 Sentence denotes Cells, transfection, treatments and luciferase assay
T4907 6615-6841 Sentence denotes HeLa, p50−/−p65−/− mouse embryonic fibroblasts (MEFs) (52) and 293T cells were cultured in Dulbecco's modified Eagle's medium; Jurkat, U937 cells and human peripheral blood mononuclear cells (PBMCs) were cultured in RPMI 1640.
T4908 6842-6891 Sentence denotes PBMCs were isolated as previously described (53).
T4909 6892-7008 Sentence denotes Media were supplemented with 10% heat-inactivated fetal calf serum and 2 mM l-glutamine (Lonza Cologne AG, Germany).
T4910 7009-7278 Sentence denotes HeLa, p50−/−p65−/− MEFs and 293T were transfected with DNA by using FuGENE HD (Roche Diagnostic GmbH, Mannheim, Germany), according to the manufacturer's protocol; total DNA amounts were equalized by transfection of pRc/CMV empty vector (Invitrogen, Carlsbad, CA, USA).
T4911 7279-7567 Sentence denotes For pulse-stimulation, HeLa cells were treated with phorbol 12-myristate 13-acetate (PMA; Sigma-Aldrich, St Louis, MO, USA) (20 ng/ml) for 5 min, or tumor necrosis factor-α (TNF-α; Sigma-Aldrich) (20 ng/ml) for 30 min, washed twice in complete culture medium and then returned to culture.
T4912 7568-7671 Sentence denotes For luciferase assays, pSV-β-Gal was co-transfected with pκBluc to monitor the transfection efficiency.
T4913 7672-7971 Sentence denotes Forty-eight-hour post-transfection, cells were lysed in lysis buffer of Dual Light Luciferase System (Tropix, Bedford, MA, USA) and the luciferase and β-galactosidase activities were evaluated by using Dual Light Luciferase System (Tropix) in a bioluminometer (Turner Biosystem, Sunnyvale, CA, USA).
T4914 7972-8079 Sentence denotes The ratio of firefly luciferase activity to β-galactosidase activity was expressed as relative light units.
T5677 8081-8097 Sentence denotes RNA interference
T5678 8098-8223 Sentence denotes Jurkat or U937 cells were transfected by electroporation using a Bio-Rad apparatus (Bio-Rad Laboratories, Hercules, CA, USA).
T5679 8224-8506 Sentence denotes Briefly, aliquots (5 × 106 cells) were suspended in 0.3 ml of RPMI 1640 supplemented with 20% fetal calf serum and subjected to a double electrical pulse (0.22 V, 960 µF) in the presence of annealed siRNA (200 pmol); electroporated cells were washed and cultured in complete medium.
T5680 8507-8726 Sentence denotes RNA interference was performed with: siRNA Tat sense, CUGCUUGUACCAAUUGCUAUU and siRNA Tat antisense, UAGCAAUUGGUACAAGCAGUU; siRNA control sense, CUGCUUGUCACA AUUGCUAUU and siRNA control antisense, UAGCAAUUGUGACAAGCAGUU.
T5681 8727-8841 Sentence denotes RNA interference of p65 and IκB-α was performed with SMART pool siRNA p65 and IκB-α (Dharmacon, Chicago, IL, USA).
T6045 8843-8889 Sentence denotes Pseudotyped virions and single round infection
T6046 8890-9072 Sentence denotes 293T cells (1 × 107) were transfected with pNL4-3.Luc.R-E- or pNL4-3.FLAG-Tat.R-E- (10 µg) together with pHXB2 Env (10 µg), and 48-h post-transfection cell supernatant was collected.
T6047 9073-9169 Sentence denotes Enzyme-linked immunosorbent assay (ELISA) using anti-p24 antibody measured virion concentration.
T6048 9170-9319 Sentence denotes PBMCs, Jurkat or U937 cells (5 × 107) were infected with HXB2 Env-pseudotyped virions (500 ng of p24) by spinoculation, as previously described (50).
T6288 9321-9388 Sentence denotes Cell extracts, western blotting, IKK activity and NF-κB DNA binding
T6289 9389-10064 Sentence denotes Total, nuclear and cytosolic extracts were performed as previously described (54); details are reported in Supplementary Data. Western blotting analysis was performed by resuspending protein aliquots in loading buffer (125 mM Tris–HCl, pH 6.8, 5% SDS, 1% bromophenol blue, 10% β-mercaptoethanol, 25% glycerol), resolved on 12% SDS–PAGE, transferred to polyvinylidene difluoride membrane (Millipore, Bedford, MA, USA) and incubated with primary antibodies (1:1000) followed by incubation with horseradish-peroxidase-linked mouse or rabbit IgG (1:2000) (GE Healthcare Amersham, Little Chalfont, Buckinghamshire, UK) in PBS containing 5% non-fat dry milk (Bio-Rad Laboratories).
T6290 10065-10155 Sentence denotes Proteins were detected by chemiluminescence using the ECL System (GE Healthcare Amersham).
T6291 10156-10195 Sentence denotes Primary antibodies were purchased from:
T6292 10196-10396 Sentence denotes Santa Cruz Biotechnology, Santa Cruz, CA, USA (anti-HA F7, anti-IκB-α C15, anti-Histone H1, anti-Hexokinase-II); Sigma-Aldrich (anti-FLAG M2, anti-γ-Tubulin); Upstate, Lake Placid, NY, USA (anti-p65).
T6293 10397-10477 Sentence denotes Densitometry of single bands was analysed by ImageJ software package (NIH, USA).
T6294 10478-10611 Sentence denotes IKK activity was evaluated in cytosolic extracts using the HTScan IKK kinase assay kit (Cell Signaling Technology, Danvers, MA, USA).
T6295 10612-10798 Sentence denotes Binding of p65, p50 and FLAG-Tat to the double-stranded NF-κB oligonucleotide was measured using NF-κB Combo Transcription Factor Assay kit (Cayman Chemical Company, Ann Arbor, MI, USA).
T6296 10799-10931 Sentence denotes Electrophoretic Mobility Shift Assay (EMSA) was performed as previously described (55); details are described in Supplementary Data.
T6715 10933-10953 Sentence denotes In vitro translation
T6716 10954-11137 Sentence denotes HA-IκB-α, p65 and Tat were expressed under the T7 promoter and in vitro translated using the TnT quick coupled transcription/translation system (Promega), as previously reported (50).
T6717 11138-11182 Sentence denotes Details are described in Supplementary Data.
T6879 11184-11227 Sentence denotes Immunoprecipitation assay and GST-pull down
T6880 11228-11370 Sentence denotes Immunoprecipitation, GST-pull down, and production of GST proteins in Escherichia coli strain BL21 were performed as previously reported (50).
T6881 11371-11415 Sentence denotes Details are described in Supplementary Data.
T7009 11417-11430 Sentence denotes Real-time PCR
T7010 11431-11681 Sentence denotes Total RNA was extracted from cells by using the TRIzol reagent (Invitrogen); RNA aliquots (200 ng) were reverse transcribed using Random Examers (Roche) and Superscript III Reverse Transcriptase (Invitrogen), according to the manufacturer's protocol.
T7011 11682-11878 Sentence denotes Real-time PCR was performed with the iQ Green Super mix (Bio-Rad Laboratories) and carried out with the iCycler iQ Real-Time detection system (Bio-Rad Laboratories) under the following conditions:
T7012 11879-11921 Sentence denotes 95°C, 1 min; (94°C, 10 s; 60°C, 30 s) ×40.
T7013 11922-12144 Sentence denotes Primers for Tat and MIP-1α are listed in Supplementary Data. Real-time PCR of CSF3, LTA, NFKBIA, TLR2, GAPDH and ACTB was performed using the RT2 profiler PCR Array-Human NF-κB signaling pathway (QIAGEN Sciences, MD, USA).
T7014 12145-12282 Sentence denotes Reactions were carried out in triplicate, and gene expression levels were calculated relative to GAPDH mRNA levels as endogenous control.
T7015 12283-12363 Sentence denotes Relative expression was calculated as 2(Ct gene under investigation − Ct GAPDH).
T7515 12365-12400 Sentence denotes Chromatin immunoprecipitation assay
T7516 12401-12490 Sentence denotes Cells were fixed by adding formaldehyde (Sigma-Aldrich) at the final concentration of 1%.
T7517 12491-12627 Sentence denotes After 10 min, ice-cold PBS plus 0.125 M glycine was added, and plates were transferred on ice, washed extensively with PBS, and scraped.
T7518 12628-12806 Sentence denotes After centrifugation, cells were 10 min lysed in lysis buffer (5 mM PIPES pH 8.0, 85 mM KCl, 0.5% NP-40) supplemented with 1× Complete Protease Inhibitor (Roche Diagnostic GmbH).
T7519 12807-12929 Sentence denotes Nuclei were pelletted (1000 × g, 5 min), and resuspended in sonication buffer (50 mM Tris–HCl pH 8.0, 1% SDS, 10 mM EDTA).
T7520 12930-13194 Sentence denotes Chromatin was sonicated using Bandelin Sonoplus GM70 (Bandelin Electronic, Berlin, Germany), centrifuged (14 000 × g, 15 min), and supernatant was 10-fold diluted in dilution buffer (0.01% SDS, 16.7 mM Tris–HCl pH 8.0, 1.1% Triton X-100, 167 mM NaCl, 1.2 mM EDTA).
T7521 13195-13345 Sentence denotes Samples were pre-cleared by 3-h incubation with 20 µl of protein G agarose beads followed by incubation with antibodies against the analysed proteins.
T7522 13346-13944 Sentence denotes Primary antibodies were: anti-p65 (sc-372), anti-IκBα (sc-203) and rabbit IgG (sc-2027) from Santa Cruz Biotechnology; anti-FLAG M2 from Sigma–Aldrich. Immunoprecipitations were carried out at 4°C overnight and immune complexes were collected with protein G agarose beads, washed five times with low salt buffer (20 mM Tris–HCl pH 8.0, 0.1% SDS, 1% Triton X-100, 2 mM EDTA, 150 mM NaCl), four times with high salt buffer (20 mM Tris–HCl pH 8.0, 0.1% SDS, 1% Triton X-100, 2 mM EDTA, 500 mM NaCl), once with TE buffer (10 mM Tris–HCl pH 8.0, 1 mM EDTA), and extracted in TE buffer containing 2% SDS.
T7523 13945-14012 Sentence denotes Protein–DNA cross-links were reverted by heating at 65°C overnight.
T7524 14013-14124 Sentence denotes DNA was further purified by QIAquick PCR purification kit (QIAGEN) and eluted in 50 µl sterile distilled water.
T7525 14125-14294 Sentence denotes Specific enrichment in NF-κB enhancer sequences was measured by real-time PCR of chromatin immunoprecipitation (ChIP) eluates using SYBR GreenER Master Mix (Invitrogen).
T7526 14295-14423 Sentence denotes Reactions were carried out with the iCycler iQ Real-Time detection system (Bio-Rad Laboratories) using the following conditions:
T7527 14424-14466 Sentence denotes 95°C, 1 min; (94°C, 10 s; 60°C, 30 s) ×40.
T7528 14467-14637 Sentence denotes Primers used for MIP-1α, GAPDH and ACTB are listed in Supplementary Data. Real-time PCR of CSF3, LTA, NFKBIA and TLR2 were performed using the Custom ChIP array (QIAGEN).
T7529 14638-14746 Sentence denotes For each sample, values were normalized to input DNA and reported as % of input over the rabbit IgG control.
T8155 14748-14768 Sentence denotes Statistical analysis
T8156 14769-14842 Sentence denotes Statistical analysis was performed by two-tail unpaired Student's t-test.
T8157 14843-14876 Sentence denotes Data were reported as means ± SE.
T8158 14877-14980 Sentence denotes Differences between the means were considered as statistically significant at the 95% level (P < 0.05).
T8532 14991-15094 Sentence denotes Tat enhances the NF-κB activity by hijacking IκB-α and inhibiting the post-activation turn off of NF-κB
T8533 15095-15229 Sentence denotes We analysed the kinetic of NF-κB activation in single round HIV-1 infection by modulating the expression of Tat with RNA interference.
T8534 15230-15398 Sentence denotes Jurkat cells were transfected with siRNA Tat, siRNA control, or left untransfected, and 24 h later cells were infected with HXB2 Env-pseudotyped NL4-3.Luc.R−E− virions.
T8535 15399-15533 Sentence denotes By cytofluorimetric analysis, ∼40% of cells was siRNA-transfected and HIV-1-infected at 12-h post-infection (Supplementary Figure S1).
T8536 15534-15756 Sentence denotes The expression of Tat was detected at 1-h post-infection and progressively increased up to 12 h in untransfected and siRNA control-transfected cells, while it was barely detected in siRNA Tat-transfected cells (Figure 1A).
T8537 15757-16051 Sentence denotes The LTR-dependent luciferase expression was also progressively induced at 1- to 12-h post-infection in untransfected and siRNA control-transfected cells, while it was barely observed in siRNA Tat-transfected cells, as expected for the Tat-dependent transactivation of the HIV-1 LTR (Figure 1A).
T8538 17245-17738 Sentence denotes The progressive increase in NF-κB activity, as measured by p65–p50 binding to an NF-κB consensus oligonucleotide (Figure 1B) and nuclear p65 (Figure 1C, nucleus), was observed at 1- to 3-h post-infection in both Tat-positive (no siRNA or siRNA control) and Tat-negative (siRNA Tat) cells; however, at 12-h post-infection, the p65 DNA binding and nuclear p65 persisted elevated in presence of Tat (no siRNA and siRNA control), while they dropped in absence of Tat (siRNA Tat) (Figure 1B and C).
T8539 17739-17942 Sentence denotes IκB-α was degraded in the cytosol within 3-h post-infection and de novo synthesized at 6 h with full replenishment at 12-h post-infection in both Tat-positive and Tat-negative cells (Figure 1C, cytosol).
T8540 17943-18094 Sentence denotes Consistently, the IKK activity was induced at 1-h post-infection, and decreased at 3-h post-infection independently of the presence of Tat (Figure 1D).
T8541 18095-18360 Sentence denotes Similar kinetics of NF-κB activity, IKK activation and IκB-α degradation/re-synthesis were observed in single-round HIV-1 infection of PBMCs using a cocktail of Azidothymidine (AZT) and Lamivudine (3TC) as reverse transcriptase inhibitors (Supplementary Figure S2).
T8542 18361-18659 Sentence denotes These results indicated that in single-round HIV-1 infection the NF-κB activation initially correlated with the IKK activation and IκB-α degradation independently of the presence of Tat, and it was kept elevated in presence of Tat following the decay of the IKK activity and new synthesis of IκB-α.
T8543 18660-18749 Sentence denotes Next, we tested the single action of Tat on the kinetic of NF-κB activity induced by PMA.
T8544 18750-18942 Sentence denotes To this end, HeLa cells were transfected with p3x-FLAG-Tat, or empty vector, stimulated with PMA for 5 min, and extensively washed to avoid the oscillatory kinetic of NF-κB activation (17,18).
T8545 18943-19143 Sentence denotes In un-stimulated cells, the p65 DNA binding (Figure 2A) and nuclear p65 (Figure 2B, nucleus) were slightly enhanced by Tat, while the IκB-α content was not significantly affected (Figure 2B, cytosol).
T8546 19144-19491 Sentence denotes Transient stimulation with PMA increased the NF-κB DNA binding activity and nuclear p65 at 5 min peaking at 60–120 min independently of the presence of Tat (Figure 2A and B); however, while the p65 DNA binding and nuclear p65 persisted elevated at 240-min post-treatment in Tat-positive cells, they dropped in Tat-negative cells (Figure 2A and B).
T8547 19492-19716 Sentence denotes In addition, Tat bound to the NF-κB oligonucleotide in un-stimulated cells and its binding increased following PMA stimulation (Figure 2A), suggesting that the viral protein was a component of the NF-κB complex bound to DNA.
T8548 19717-19913 Sentence denotes Degradation of IκB-α was progressively induced at 5–30 min, followed by de novo synthesis at 60 min with full replenishment at 240 min in both Tat-positive and negative cells (Figure 2B, cytosol).
T8549 19914-20039 Sentence denotes Consistently, the IKK activation started at 5 min, and turned off at 30 min independently of the presence of Tat (Figure 2C).
T8550 20040-20196 Sentence denotes These results indicated that Tat enhanced the NF-κB activity in un-stimulated and PMA-stimulated cells without affecting the IKK activity and IκB-α content.
T8551 21813-21967 Sentence denotes As we previously found that Tat binds to the sixth ankyrin of IκB-α (50,51), we tested whether Tat counteracted the generation of the IκB-α/NF-κB complex.
T8552 21968-22195 Sentence denotes To this end, the association of IκB-α with p65 was analysed in vivo at 0 and 240 min after short-pulse PMA, which corresponded to the time of un-stimulated condition and post-activation de novo synthesis of IκB-α, respectively.
T8553 22196-22494 Sentence denotes Coimmunoprecipitation of IκB-α with p65 was detected at 0- and 240-min post-treatment in Tat-negative cells (Figure 2D, lanes 1 and 3), and was halved in Tat-positive cells, where Tat coimmunoprecipitated with IκB-α (Figure 2D, lanes 2 and 4), indicating that Tat competed the IκB-α binding to p65.
T11602 22496-22574 Sentence denotes Tat counteracts the IκB-α inhibition of p65 by competing the repressor binding
T11603 22575-22709 Sentence denotes We further investigated the physical interaction of Tat with IκB-α using in vitro translated proteins in coimmunoprecipitation assays.
T11604 22710-22781 Sentence denotes For mapping the interaction domains, we used the following Tat mutants:
T11605 22782-22861 Sentence denotes Tat T,N(23,24)A, Tat C(22,25,27)A, Tat K(50,51)A and Tat R(49–57)A (Figure 3A).
T11606 22862-22945 Sentence denotes IκB-α coimmunoprecipitated with all Tat proteins, except Tat R(49–57)A (Figure 3B).
T11607 22946-23101 Sentence denotes These results indicated that the arginine-rich domain of Tat was involved in the binding to IκB-α, which was consistent with previous observations (50,51).
T11608 23102-23389 Sentence denotes Moreover, Tat associating with IκB-α competed the binding of IκB-α to p65 in a dose-dependent manner (Figure 3C, lanes 3–5), while Tat R(49–57)A, which lacked the binding site for IκB-α, did not associate with IκB-α and did not compete the binding of IκB-α to p65 (Figure 3C, lanes 6–8).
T11609 25484-25705 Sentence denotes Next, we evaluated whether Tat counteracted the IκB-α-mediated inhibition of p65 binding to DNA by incubating in vitro translated p65 and IκB-α proteins with the NF-κB probe in presence or absence of Tat followed by EMSA.
T11610 25706-25852 Sentence denotes The p65 DNA binding activity was inhibited by IκB-α and restored in a dose-dependent manner by wild-type Tat, and not by Tat R(49–57) (Figure 3D).
T11611 25853-26258 Sentence denotes Further, we analysed the Tat effect on the IκB-α repression of p65 transcriptional activity by transfecting p50−/−p65−/−MEFs with the NF-κB-Luc reporter together with expression vectors of p65 and IκB-α, in presence or absence of Tat. IκB-α inhibited the p65-dependent expression of the luciferase gene, which was restored in a dose-dependent manner by wild-type Tat, and not by Tat R(49–57)A (Figure 3E).
T11612 26259-26457 Sentence denotes Altogether these results indicated that Tat counteracts the IκB-α repression of the p65 DNA-binding and transcriptional activity by associating with IκB-α and competing the repressor binding to p65.
T13324 26459-26533 Sentence denotes Tat increases the p65 affinity binding to DNA through association with p65
T13325 26534-26587 Sentence denotes We tested whether Tat physically interacted with p65.
T13326 26588-26729 Sentence denotes HeLa cells were transfected with the expression vectors of HA-p65 and FLAG-Tat, and 24 h later Tat was immunoprecipitated from cell extracts.
T13327 26730-26973 Sentence denotes The p65 protein was coimmunoprecipitated with wild-type Tat or the mutants Tat T,N(23,24)A, Tat K(50,51)A and Tat R(49–57)A at similar levels, while a significant decrease in coimmunoprecipitation was observed for Tat C(22,25,27)A (Figure 4A).
T13328 26974-27202 Sentence denotes Consistently, GST-pull down of in vitro translated proteins showed the direct binding of p65 to wild-type Tat, or the mutants Tat T,N(23,24)A, Tat K(50,51)A and Tat R(49–57)A, and lack of binding to Tat C(22,25,27)A (Figure 4B).
T13329 27203-27368 Sentence denotes These results indicated that Tat associated with p65 through the cysteine-rich domain and ruled-out the requirement of bridging proteins to mediate such interaction.
T13330 29093-29328 Sentence denotes To identify the p65 domain required for binding to Tat, HeLa cells were transfected with FLAG-Tat together with HA-p65 mutants, which were deleted of the transactivation domain [p65ΔC (1–318)], or the RHD [p65ΔN (122–551)] (Figure 4C).
T13331 29329-29497 Sentence denotes Tat coimmunoprecipitated with p65ΔC (1–318), and not with p65ΔN (122–551) (Figure 4D), indicating that the RHD of p65 was involved in the physical interaction with Tat.
T13332 29498-29764 Sentence denotes To address the effect of Tat on the p65 DNA-binding affinity, purified recombinant p65 protein was incubated with 32P-labeled-NF-κB double-stranded oligonucleotide in presence or absence of wild-type Tat or Tat C(22,25,27)A, and p65 DNA-binding was analysed by EMSA.
T13333 29765-29929 Sentence denotes Whereas wild-type Tat significantly increased the binding of p65 to DNA, the mutant Tat C(22,25,27)A, lacking the binding site for p65, was ineffective (Figure 4E).
T13334 29930-30143 Sentence denotes The p65 binding to DNA was evaluated by competition with increasing amounts of cold competitor NF-κB oligonucleotide, which showed that Tat significantly enhanced the p65 affinity binding to DNA (Figure 4E and F).
T15219 30145-30300 Sentence denotes Tat activates the p65-dependent expression of NF-κB-responsive genes, occupies the NF-κB enhancers and promotes the p65 recruitment with IκB-α displacement
T15220 30301-30383 Sentence denotes We analysed the action of Tat on the expression of NF-κB-responsive genes in vivo.
T15221 30384-30582 Sentence denotes To this end, HeLa cells were transfected with FLAG-Tat, FLAG-Tat C(22,25,27)A or FLAG-Tat R(49–57)A, and 48 h later the expression of a number of NF-κB-dependent genes was analysed by real-time PCR.
T15222 30583-30749 Sentence denotes Tat significantly increased the expression of MIP-1α, CSF3, LTA, NFKBIA and TLR2, while the mutants Tat C(22,25,27)A and Tat R(49–57)A were ineffective (Figure 5A–E).
T15223 30750-30956 Sentence denotes The Tat-dependent transactivation of the NF-κB-dependent genes was abolished when cells were transfected with siRNA p65, indicating that the Tat transcriptional activation was mediated by p65 (Figure 5A–E).
T15224 30957-31093 Sentence denotes Differently, the expression of the NF-κB-independent genes GAPDH and ACTB was unaffected by wild-type and Tat mutants (Figure 5F and G).
T15225 31094-31383 Sentence denotes These results were consistent with the requirement of both the cysteine-rich and arginine-rich domains of Tat to enhance the NF-κB activity, suggesting that the up-regulation of NF-κB-responsive genes by Tat might occur through physical interaction of the viral protein with p65 and IκB-α.
T15226 32978-33115 Sentence denotes MIP-1α, which was the mostly activated gene by Tat, encodes for a chemokine that promotes the recruitment of pro-inflammatory cells (56).
T15227 33116-33331 Sentence denotes Consistently with our findings, MIP-1α expression was increased in glial cells and lymph nodes of AIDS patients (57,58); moreover, MIP-1α production was induced by HIV-1 infection (59,60) and Tat protein (57,61,62).
T15228 33332-33403 Sentence denotes The transcriptional regulation of MIP-1α has been poorly characterized.
T15229 33404-33669 Sentence denotes Jaspar-based analysis (http://jaspar.genereg.net/) predicted three putative NF-κB enhancers in the proximal promoter region of the MIP-1α gene: NF-κB1, −1023/−1014 nucleotides; NF-κB2, −661/−652 nucleotides; NF-κB3, +370/+379 nucleotides (Supplementary Figure S3A).
T15230 33670-33917 Sentence denotes To validate the predicted NF-κB binding sites of the MIP-1α promoter, we stimulated HeLa cells with TNF-α, a well-known NF-κB inducer, and measured the expression levels of MIP-1α by real-time PCR, and the p65 occupancy of the NF-κB sites by ChIP.
T15231 33918-34127 Sentence denotes TNF-α activated the expression of MIP-1α and induced the p65 recruitment to the NF-κB1 site of MIP-1α without affecting the occupancy of the putative NF-κB2 and NF-κB3 sites (Supplementary Figure S3B and S3C).
T15232 34128-34287 Sentence denotes Tat also promoted the recruitment of p65 to the NF-κB1 site of MIP-1α, while it did not affect the putative NF-κB2 and NF-κB3 sites (Supplementary Figure S3D).
T15233 34288-34434 Sentence denotes Altogether these results indicated that the NF-κB1 site was the only effective NF-κB enhancer of the MIP-1α promoter in response to TNF-α and Tat.
T15234 34435-34619 Sentence denotes Similarly to MIP-1α, Tat increased the recruitment of p65 to the NF-κB enhancers of CSF3, LTA, NFKBIA and TLR2, while it was ineffective at the promoters of GAPDH and ACTB (Figure 5H).
T15235 34620-34839 Sentence denotes By ChIP, Tat bound to the NF-κB-responsive promoters, and not to the GAPDH and ACTB promoters, with loss of binding following p65 RNA interference (Figure 5I), suggesting that Tat occupancy occurred via p65 interaction.
T15236 34840-35098 Sentence denotes As additional findings, IκB-α was chromatin-immunoprecipitated at the NF-κB enhancers in absence of Tat, and it was significantly removed in presence of Tat, or following IκB-α RNA interference (Figure 5J), indicating that Tat displaced IκB-α from promoters.
T17783 35100-35247 Sentence denotes In HIV-1-infected monocytes Tat sustains the NF-κB activity and promotes the transcriptional activation of MIP-1α by interacting with IκB-α and p65
T17784 35248-35367 Sentence denotes We next analysed whether Tat affected the NF-κB activity and the expression of MIP-1α in the course of HIV-1 infection.
T17785 35368-35536 Sentence denotes To detect the Tat protein, we produced HXB2 Env-pseudotyped NL4-3.FLAG-Tat.R−E− virions, which were used in single-round infection of U937, a human monocytic cell line.
T17786 35537-35724 Sentence denotes Cells were transfected with siRNA Tat, siRNA control or left untransfected to modulate the Tat expression, and then analysed for the kinetic of NF-κB activation following viral infection.
T17787 35725-35870 Sentence denotes The expression of Tat and p24 was detected at 3- to 12-h post-infection, while it was barely detected in siRNA Tat-transfected cells (Figure 6A).
T17788 38126-38359 Sentence denotes The NF-κB activity, as measured by p65 DNA binding, was induced at 3-h post-infection in both Tat-positive (no siRNA and siRNA control) and Tat-negative cells (siRNA Tat), and increased at 12 h only in Tat-positive cells (Figure 6B).
T17789 38360-38518 Sentence denotes Degradation of IκB-α was observed at 3-h post-infection, and was followed by de novo synthesis of IκB-α at 12 h independently of the Tat presence (Figure 6C).
T17790 38519-38653 Sentence denotes Consistently, the IKK activity was induced at 3-h post-infection and turned off at 12 h independently of the Tat presence (Figure 6D).
T17791 38654-38882 Sentence denotes These results agreed with the kinetic of NF-κB activation in single-round HIV-1 infection of Jurkat cells (Figure 1), and further supported the requirement of viral expression to counteract the post-activation turn off of NF-κB.
T17792 38883-39136 Sentence denotes In HIV-1-infected U937 cells, the endogenous Tat was coimmunoprecipitated with IκB-α and p65 (Figure 6E), and activated the MIP-1α expression in a p65-dependent manner, as shown by the lack of effect following RNA interference of Tat or p65 (Figure 6F).
T17793 39137-39281 Sentence denotes Moreover, Tat and p65 were both recruited to the NF-κB enhancer of MIP-1α, while the p65 occupancy was abolished by siRNA Tat (Figure 6G and H).
T17794 39282-39525 Sentence denotes Altogether these results indicated that in single round HIV-1 infection Tat associated with IκB-α and p65, and induced the p65-dependent activation of MIP-1α expression through occupancy of the MIP-1α promoter and increased recruitment of p65.
T19880 39538-39627 Sentence denotes This study reports a novel mechanism of NF-κB activation by the HIV-1 Tat transactivator.
T19881 39628-39901 Sentence denotes Based on the evidence that Tat enhanced the transcriptional activity of the p65 subunit of NF-κB (49,63,64), and physically interacted with the IκB-α repressor (50,51), we investigated the possibility that Tat could activate NF-κB via direct interaction with IκB-α and p65.
T19882 39902-40033 Sentence denotes To this end, the NF-κB activity was monitored in single round HIV-1 infection using RNA interference to silence the Tat expression.
T19883 40034-40186 Sentence denotes By this approach, we avoided the perpetuation of NF-κB activation signaling due to subsequent rounds of viral entry in cell culture propagation (30,31).
T19884 40187-40512 Sentence denotes Upon HIV-1 infection, the early NF-κB activation occurred concomitantly with IKK activation and IκB-α degradation in the absence of Tat. Soon after the shut off of IKK activity and new synthesis of IκB-α, the NF-κB activity was kept elevated in the presence of Tat, while it was down regulated upon silencing of the Tat gene.
T19885 40513-40669 Sentence denotes These findings indicate that in single round HIV-1 infection, Tat enhanced the NF-κB activity without affecting the IKK activity and the half-life of IκB-α.
T19886 40670-40867 Sentence denotes Similar kinetic of NF-κB activation occurred upon short-pulse of PMA in Tat-transfected HeLa cells, where Tat inhibited the post-activation turn off of NF-κB in presence of newly synthesized IκB-α.
T19887 40868-41033 Sentence denotes The Tat-dependent activation of NF-κB correlated with the association of the viral protein with IκB-α, which interfered with the generation of the IκB-α/p65 complex.
T19888 41034-41153 Sentence denotes This evidence demonstrated that Tat competed for the binding of IκB-α to p65 and prevented the IκB-α repression of p65.
T19889 41154-41490 Sentence denotes As additional mechanism of NF-κB activation, Tat associated with p65 and increased the p65 binding affinity to the NF-κB enhancer; this evidence was obtained with recombinant proteins indicating that the stronger binding of p65 to DNA was a consequence of direct association with Tat, which likely caused a conformational change of p65.
T19890 41491-41627 Sentence denotes We also demonstrated that the Tat cysteine-rich sequence (C22,25,27) was involved in the binding to the RHD of p65 and NF-κB activation.
T19891 41628-41809 Sentence denotes Differently, the Tat arginine-rich sequence (R49,52,53,55,56,57) was required for the binding to the sixth ankyrin of IκB-α (50,51), and for releasing p65 from the IκB-α inhibition.
T19892 41810-42018 Sentence denotes Altogether these results demonstrated that Tat abolished the negative feedback regulation of NF-κB by hijacking the IκB-α repressor, shielding p65 from the IκB-α embrace, and enforcing the p65 binding to DNA.
T19893 42019-42282 Sentence denotes Further evidence of Tat activation of NF-κB showed that wild-type Tat, and not the Tat mutants lacking the arginine- or cysteine-rich domains, up-regulated in vivo the expression of a number of NF-κB-responsive genes, including MIP-1α, CSF3, LTA, NFKBIA and TLR2.
T19894 42283-42438 Sentence denotes By ChIP analysis, we observed that Tat increased the recruitment of p65 to the NF-κB enhancers of the activated genes, and was recovered at the same sites.
T19895 42439-42585 Sentence denotes RNA interference of p65 abolished the Tat occupancy of the NF-κB enhancers indicating that the Tat binding to the NF-κB sites was mediated by p65.
T19896 42586-42785 Sentence denotes These results were consistent with the evidence that Tat displaced p65 from the binding to IκB-α (Figures 2D and 3C), and increased the p65 DNA binding affinity through association (Figure 4E and F).
T19897 42786-42962 Sentence denotes Thus, Tat likely increased the recruitment of p65 to the NF-κB-dependent promoters by associating with p65 and by interfering with the assembly of p65 with the repressor IκB-α.
T19898 42963-43205 Sentence denotes Of interest, IκB-α was found associated to the NF-κB enhancers in absence of Tat, where it was displaced in presence of Tat. These results suggest a negative regulatory role of IκB-α in gene regulation through occupancy of specific promoters.
T19899 43206-43412 Sentence denotes Indeed, IκB-α was found associated with hystone deacetylases at the hes1 promoter, from where it was removed following TNF-α stimulation causing histone acetylation and hes1 transcriptional activation (65).
T19900 43413-43621 Sentence denotes A similar mechanism of gene regulation could apply to the NF-κB-dependent genes analysed in this study, where Tat could activate the gene expression by removing IκB-α and promoting the p65 loading (Figure 7).
T19901 44045-44541 Sentence denotes The physiological relevance of Tat cross talk with NF-κB was demonstrated in the HIV-1 infection of human monocytes, where HIV-1-encoded Tat protein counteracted post-activation turn off of NF-κB, as shown by: (i) sustained NF-κB activity by Tat in presence of newly synthesized IκB-α; (ii) coimmunoprecipitation of Tat with IκB-α and p65; (iii) induction of MIP-1α expression dependent on Tat and p65; (iv) Tat occupancy of the MIP-1α NF-κB enhancer associated with increased recruitment of p65.
T19902 44542-44645 Sentence denotes This study supports the pro-inflammatory action of Tat through physical interaction with p65 and IκB-α.
T19903 44646-44832 Sentence denotes Several inflammatory cytokines under the transcriptional control of NF-κB are hyper-expressed in HIV-1 infected individuals, including IL-6 (66,67), TNF-α (68), and MIP-1α (57–62,69–71).
T19904 44833-45025 Sentence denotes In the case of TNF-α and IL-6, Tat activated the cytokine expression by binding to the TAR-like stem loop of the 5′ transcript, thus likely promoting the transcriptional elongation (33,37,47).
T19905 45026-45245 Sentence denotes Here, we have shown that the Tat-dependent transcriptional activation of a number of pro-inflammatory genes required the assembly of Tat with p65 at the NF-κB enhancer together with the displacement of IκB-α (Figure 5).
T19906 45246-45467 Sentence denotes Thus, in the set of distinct NF-κB-responsive genes, Tat acted as a component of the transcriptional initiation complex, which is consistent with previous reports on Tat promoting the transcription via DNA motifs (72,73).
T19907 45468-45612 Sentence denotes Overproduction of pro-inflammatory cytokines is considered a major mechanism of immune deregulation (26) and neuron dysfunction in AIDS (74,75).
T19908 45613-45803 Sentence denotes In this scenario, inhibition of NF-κB activity could lead to a therapeutic strategy for counteracting the abnormal production of pro-inflammatory cytokines and chemokines in HIV-1 infection.
T19909 45804-46069 Sentence denotes NF-κB inhibitors, such as anti-oxidants, proteasome and IKK inhibitors, significantly reduced the HIV-1 replication and the associated inflammatory response (76,77); however, these NF-κB inhibitors acted indiscriminately in both HIV-1-infected and uninfected cells.
T19910 46070-46232 Sentence denotes The evidence that Tat activates NF-κB through direct interaction with IκB-α and p65 may lead to specific inhibitors to counteract the Tat pro-inflammatory action.
T23911 16062-16148 Sentence denotes Tat counteracts the post-activation turn off of NF-κB in single round HIV-1-infection.
T23912 16149-16861 Sentence denotes Jurkat cells (5 × 107) were transfected with siRNA Tat or siRNA control (2 nmol), or left untransfected; 24 h later, cells were infected with HXB2-pseudotyped NL4-3.Luc.R−E− virions (500 ng of p24) and harvested at the indicated time. (A) Tat expression was measured in total RNA by real-time PCR, while the luciferase activity was measured in whole cell extracts. (B) Nuclear extracts (10 µg) were analysed for the p65 and p50 binding to the NF-κB double-stranded oligonucleotide using the NF-κB Transcription Factor ELISA Assay kit (Cayman). (C) The expression of p65 and IκB-α was analysed by 12% SDS–PAGE and western blotting of nuclear or cytosolic extracts (20 µg) using anti-p65 and anti-IκB-α antibodies.
T23913 16862-16989 Sentence denotes Histone H1 and Hexokinase II were detected with specific antibodies as markers of nuclear and cytosolic extracts, respectively.
T23914 16990-17207 Sentence denotes Densitometry values (D) of the bands were expressed as fold increase above the control (mock). (D) IKK activity was measured in cytosolic extracts (100 µg) by using HTScan IKK Kinase Assay (Cell Signaling Technology).
T23915 17208-17244 Sentence denotes Values (mean ± SE, n = 3) are shown.
T24351 20207-20330 Sentence denotes Tat enhances the NF-κB activity following PMA stimulation by associating with IκB-α and counteracting the NF-κB repression.
T24352 20331-20558 Sentence denotes HeLa cells (5 × 106) were transfected with p3xFLAG-Tat or p3xFLAG empty vector (5 µg), and 48 h later were stimulated with PMA (5 min, 20 ng/ml) or left unstimulated, washed twice with DMEM and harvested at the indicated times.
T24353 20559-21007 Sentence denotes Nuclear and cytosolic extracts were prepared for further analysis. (A) Nuclear extracts were analysed for the p65, p50 and FLAG-Tat binding to the NF-κB double-stranded oligonucleotide using the NF-κB Transcription Factor ELISA assay kit (Cayman). (B) Nuclear and cytosolic extracts (20 µg) were separated by 12% SDS–PAGE and analysed by western blotting using the anti-p65, anti-FLAG, anti-Histone H1, anti-IκB-α and anti-Hexokinase-II antibodies.
T24354 21008-21441 Sentence denotes Densitometry values (D) of the bands were expressed as fold increase above the control (lane 1). (C) IKK activity was measured in cytosolic extracts (100 µg) by using HTScan IKK kinase assay (Cell Signaling Technology). (D) HeLa cells (5 × 106) were transfected with or without p3xFLAG-Tat (5 µg); 48 h later, cells were stimulated with PMA (5 min, 20 ng/ml) or left unstimulated, washed twice with DMEM, and harvested after 240 min.
T24355 21442-21546 Sentence denotes Whole cell extracts (1 mg) were immunoprecipitated with protein G-Sepharose-coupled anti-IκB-α antibody.
T24356 21547-21678 Sentence denotes Immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-p65, anti-FLAG and anti-IκB-α antibodies.
T24357 21679-21775 Sentence denotes Densitometry values (D) of the bands were expressed as fold increase above the control (lane 1).
T24358 21776-21812 Sentence denotes Values (mean ± SE, n = 3) are shown.
T25204 23400-23710 Sentence denotes Tat relieves p65 from the IκB-α inhibition. (A) Schematic representation of wild-type and mutant Tat proteins. (B) HA-IκB-α (5 µl) was incubated in presence or absence of FLAG-Tat, FLAG-Tat T,N(23,24)A, FLAG-Tat K(50,51)A, FLAG-Tat R(49–57)A or FLAG-Tat C(22,25,27)A (10 µl) using in vitro translated proteins.
T25205 23711-24080 Sentence denotes Wild-type and mutant Tat proteins were immunoprecipitated with anti-FLAG antibody; immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-HA and anti-FLAG antibodies. (C) 35S-methionine-labeled p65 (5 µl) was incubated with in vitro translated HA-IκB-α (5 µl) in presence or absence of FLAG-Tat or FLAG-Tat R(49–57)A (5, 10 or 20 µl).
T25206 24081-24288 Sentence denotes HA-IκB-α was immunoprecipitated with anti-HA antibody; immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-HA and anti-FLAG antibodies, or autoradiography (35S-Met-p65).
T25207 24289-24475 Sentence denotes Densitometry values (D) of the bands were expressed as fold increase above the control (lane 1). (D) The p65 DNA binding activity was analysed by EMSA using in vitro translated proteins.
T25208 24476-24777 Sentence denotes 32P-labeled-NF-κB double-stranded oligonucleotide was incubated with p65 (0.5 µl) in presence or absence of HA-IκB-α (1 µl), FLAG-Tat or FLAG-Tat R(49–57)A (5 and 10 µl); competition of DNA binding was performed with 10 - up to 100-fold molar excess of unlabeled NF-κB double-stranded oligonucleotide.
T25209 24778-25073 Sentence denotes DNA/protein complexes were run on 6% PAGE–TBE and analysed by autoradiography. (E) p50−/−p65−/−MEFs (3 × 105 cells) were transfected with pκBLuc (0.5 µg) and pSV-β-Gal (0.1 µg) with or without pRc/CMV-p65 (0.5 µg), pCMV4-HA-IκB-α (0.5 µg), p3xFLAG-Tat or p3xFLAG-Tat R(49–57)A (0.5, 1 and 2 µg).
T25210 25074-25194 Sentence denotes The luciferase activity was measured in cell extracts 48-h post-transfection and normalized to β-galactosidase activity.
T25211 25195-25279 Sentence denotes Fold activation was calculated relative to transfection of the pκBLuc plasmid alone.
T25212 25280-25316 Sentence denotes Values (mean ± SE, n = 3) are shown.
T25213 25317-25483 Sentence denotes As control of protein expression, aliquots of cell extracts (20 µg) were analysed by western blotting with anti-p65, anti-HA, anti-FLAG and anti-γ-tubulin antibodies.
T26499 27379-27646 Sentence denotes Tat associates with p65 increasing its DNA-affinity binding. (A) HeLa cells were transfected with pRc/CMV-3xHA-p65 (5 µg) in presence or absence of p3xFLAG-Tat, p3xFLAG-Tat T,N(23,24)A, p3xFLAG-Tat K(50,51)A, p3xFLAG-Tat R(49–57)A, or p3xFLAG-Tat C(22,25,27)A (5 µg).
T26500 27647-28416 Sentence denotes FLAG-Tat proteins were immunoprecipitated with anti-FLAG antibody; immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-FLAG or anti-HA antibodies. (B) In vitro translated p65 (5 µl) was incubated with GST-Tat, GST-Tat T,N(23,24)A, GST-Tat K(50,51)A, GST-Tat R(49–57)A, GST-Tat C(22,25,27)A, or GST (5 µg) conjugated with Glutathione-Sepharose. Protein complexes were recovered by GST-pull down, separated by 12% SDS–PAGE, and analysed by western blotting with anti-p65 or anti-GST antibodies. (C) Schematic representation of wild-type and mutant p65 proteins. (D) HeLa cells were transfected with p3xFLAG-Tat (5 µg) in the presence or absence of pRc/CMV-3xHA-p65, pRc/CMV-3xHA-p65ΔC (1–318), or pRc/CMV-3xHA-p65ΔN (122–551) (5 µg).
T26501 28417-28947 Sentence denotes Wild-type and mutant HA-p65 proteins were immunoprecipitated with anti-HA antibody; immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-FLAG or anti-HA antibodies. (E) Recombinant p65 protein (100 ng; Active Motif Carlsbad, CA, USA) was 20 min incubated with 32P-labeled NF-κB double-stranded oligonucleotide in presence or absence of in vitro translated FLAG-Tat or FLAG-Tat C(22,25,27)A (5 µl); competitions were performed with 1.25- up to 40-fold molar excess of unlabeled oligonucleotide.
T26502 28948-29092 Sentence denotes DNA/protein complexes were separated by 6% PAGE in 0.5 × TBE buffer and analysed by autoradiography. (F) Densitometry of band-shifts shown in E.
T27258 31394-31554 Sentence denotes Tat activates the p65-dependent expression of NF-κB-responsive genes by occupying the NF-κB enhancers and promoting the p65 recruitment with IκB-α displacement.
T27259 31555-31808 Sentence denotes HeLa cells (5 × 106) were transfected with p3xFLAG-Tat, p3xFLAG-Tat C(22,25,27), p3xFLAG-Tat R(49–57) or empty vector (10 µg); for p65 RNA interference, cells (5 × 106) were transfected with p3xFLAG-Tat (10 µg) and siRNA p65 or siRNA control (200 pmol).
T27260 31809-32150 Sentence denotes Twenty-four-hour post-transfection, total RNA was extracted and analysed by real-time PCR to evaluate the expression of MIP-1α (A), CSF3 (B), LTA (C), NFKBIA (D), TLR2 (E), GAPDH (F), ACTB (G) genes. (H) HeLa cells (5 × 106) were transfected with p3xFLAG-Tat, or empty vector (10 µg) and 48 h later ChIP was performed with anti-p65 antibody.
T27261 32151-32435 Sentence denotes Real-time PCR was performed with primers specific for the indicated promoters. (I) HeLa cells (5 × 106) were transfected with empty vector, or p3xFLAG-Tat (10 µg) in presence or absence of siRNA p65, or siRNA control (200 pmol); 48 h later, ChIP was performed with anti-FLAG antibody.
T27262 32436-32715 Sentence denotes Real-time PCR was performed with primers specific for the indicated promoters. (J) HeLa cells (5 × 106) were transfected with empty vector, p3xFLAG-Tat (10 µg), or empty vector plus siRNA IκB-α or siRNA control (200 pmol); 48 h later, ChIP was performed with anti-IκB-α antibody.
T27263 32716-32794 Sentence denotes Real-time PCR was performed with primers specific for the indicated promoters.
T27264 32795-32831 Sentence denotes Values (mean ± SE, n = 3) are shown.
T27265 32832-32977 Sentence denotes The asterisks indicate statistically significant differences compared to the control (empty vector) according to the Student's t-test (P < 0.05).
T28289 35881-36002 Sentence denotes In HIV-1 infection Tat sustains the NF-κB activity and enhances the MIP-1α expression via interaction with IκB-α and p65.
T28290 36003-36655 Sentence denotes U937 cells (5 × 107) were transfected with siRNA Tat, siRNA control (2 nmol), or left untransfected; 24 h later cells were infected with HXB2-pseudotyped NL4-3.FLAG-Tat.R−E− virions (500 ng of p24) and harvested at the indicated time. (A) Real-time PCR of total RNA measured the Tat expression; ELISA measured the amount of p24 in whole cell extracts. (B) The binding of p65 to the NF-κB double-stranded oligonucleotide was measured in nuclear extracts (10 µg) using the NF-κB Transcription Factor ELISA assay kit (Cayman). (C) The IκB-α content was analysed by 12% SDS–PAGE and western blotting of cytosolic extracts (20 µg) using anti-IκB-α antibody.
T28291 36656-36985 Sentence denotes Densitometry values (D) of the bands were expressed as fold increase above the control (mock). (D) IKK activity was measured in cytosolic cell extracts (100 µg) using HTScan IKK Kinase Assay (Cell Signaling Technology). (E) U937 cells (5 × 107) were infected with HXB2-pseudotyped NL4-3.FLAG-Tat.R−E− virions, or left uninfected.
T28292 36986-37116 Sentence denotes Twenty-four-hour post-infection, cell extracts (1 mg) were immunoprecipitated with protein G-Sepharose-coupled anti-FLAG antibody.
T28293 37117-37467 Sentence denotes Immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-p65, anti-FLAG and anti-IκB-α antibodies. (F) U937 cells (5 × 107) were transfected with siRNA Tat, siRNA p65, siRNA control (2 nmol), or left untransfected; 24 h later, cells were infected with HXB2-pseudotyped NL4-3.FLAG-Tat.R−E− virions, or left uninfected.
T28294 37468-37779 Sentence denotes Twenty-four-hour post-infection, total RNA was analysed for MIP-1α expression by real-time PCR. (G and H) U937 cells (5 × 107) were transfected with siRNA Tat or siRNA control (2 nmol), or left untransfected; 24 h later, cells were infected with HXB2-pseudotyped NL4-3.FLAG-Tat.R−E− virions, or left uninfected.
T28295 37780-37867 Sentence denotes Twenty-four-hour post-infection, ChIP was performed with anti-p65 (G) or anti-FLAG (H).
T28296 37868-37949 Sentence denotes Real-time PCR was performed with primers specific for MIP-1α and GAPDH promoters.
T28297 37950-37986 Sentence denotes Values (mean ± SE, n = 3) are shown.
T28298 37987-38125 Sentence denotes The asterisks indicate statistically significant differences compared to the control (mock), according to the Student's t-test (P < 0.05).
T29103 43632-44044 Sentence denotes Model of MIP-1α transcriptional activation by HIV-1 Tat. (A) In absence of Tat, IκB-α occupies the NF-κB enhancer of the MIP-1α promoter and likely interacts with transcriptional repressors, such as HDACs (65), to inhibit gene transcription. (B) Tat activates the MIP-1α expression by removing the IκB-α repressor from the NF-κB enhancer, and by increasing the binding of p65 NF-κB complex to the NF-κB enhancer.
T1 0-94 Sentence denotes Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65
T2 97-105 Sentence denotes Abstract
T3 106-248 Sentence denotes Nuclear factor (NF)-κB is a master regulator of pro-inflammatory genes and is upregulated in human immunodeficiency virus 1 (HIV-1) infection.
T4 249-347 Sentence denotes Mechanisms underlying the NF-κB deregulation by HIV-1 are relevant for immune dysfunction in AIDS.
T5 348-568 Sentence denotes We report that in single round HIV-1 infection, or single-pulse PMA stimulation, the HIV-1 Tat transactivator activated NF-κB by hijacking the inhibitor IκB-α and by preventing the repressor binding to the NF-κB complex.
T6 569-696 Sentence denotes Moreover, Tat associated with the p65 subunit of NF-κB and increased the p65 DNA-binding affinity and transcriptional activity.
T7 697-841 Sentence denotes The arginine- and cysteine-rich domains of Tat were required for IκB-α and p65 association, respectively, and for sustaining the NF-κB activity.
T8 842-1148 Sentence denotes Among an array of NF-κB-responsive genes, Tat mostly activated the MIP-1α expression in a p65-dependent manner, and bound to the MIP-1α NF-κB enhancer thus promoting the recruitment of p65 with displacement of IκB-α; similar findings were obtained for the NF-κB-responsive genes CSF3, LTA, NFKBIA and TLR2.
T9 1149-1358 Sentence denotes Our results support a novel mechanism of NF-κB activation via physical interaction of Tat with IκB-α and p65, and may contribute to further insights into the deregulation of the inflammatory response by HIV-1.
T10 1360-1372 Sentence denotes INTRODUCTION
T11 1373-1516 Sentence denotes Nuclear factor (NF)-κB transcription factors regulate the transcription of genes that are involved in the immune and inflammatory response (1).
T12 1517-1698 Sentence denotes The NF-κB family includes RelA/p65, c-Rel, RelB, p50 and p52 that share a highly conserved 300-amino acid Rel homology domain (RHD) for homo- or hetero-dimerization and DNA-binding.
T13 1699-1891 Sentence denotes The transcriptional activity of the NF-κB complex depends on dimer composition since C-terminal unrelated transcriptional activation domains are present exclusively in p65, RelB and c-Rel (2).
T14 1892-1993 Sentence denotes Inhibitors of NF-κB (IκB) associate with the NF-κB complex and interfere with its binding to DNA (3).
T15 1994-2248 Sentence denotes In the canonical pathway of NF-κB activation, the activated IκB kinase (IKK) phosphorylates IκB at specific serine residues that target the protein to ubiquitination and proteasomal degradation, which releases the functional NF-κB complex in the nucleus.
T16 2249-2438 Sentence denotes IκB-α, the most abundant inhibitor of NF-κB (4), is phosphorylated by IKK at Ser32 and Ser36 (5), and subsequently ubiquitylated at Lys21 and Lys22 to be degraded by the 26S proteasome (6).
T17 2439-2575 Sentence denotes The NF-κB activity is enhanced by phosphorylation of p65 at Ser276 by PKA and MSK1 (7,8), Ser311 by PKCζ (9) and Ser536 by IKKα (10,11).
T18 2576-2758 Sentence denotes Acetylation of p65 at Lys218 and Lys221 increases the DNA binding and impairs the association with IκB-α, and acetylation at Lys310 enhances the p65 transcriptional activity (12,13).
T19 2759-2951 Sentence denotes Post-activation turn off of NF-κB is regulated by negative feedback loop through inhibitors under the transcriptional control of NF-κB, such as IκB-α and ubiquitin-editing protein A20 (14–20).
T20 2952-3095 Sentence denotes Deacetylation of p65 by histone deacetylase-3 or SIRT1, or acetylation of p65 at Lys122 and Lys123 down-regulate the NF-κB activity (12,21,22).
T21 3096-3363 Sentence denotes Persistent activation of NF-κB occurs in human immunodeficiency virus-1 (HIV-1)-infected monocytes, macrophages and microglia, and enhances the expression of NF-κB-responsive genes, including pro-inflammatory cytokines, cell adhesion molecules and chemokines (23–25).
T22 3364-3451 Sentence denotes Chronic inflammation is a major cause of immune and neuron dysfunction in AIDS (26,27).
T23 3452-3670 Sentence denotes Consistently, non-human primate hosts for simian immunodeficiency virus, such as African green monkeys and sooty mangabey, lack aberrant immune activation and do not develop AIDS despite high virus replication (28,29).
T24 3671-3789 Sentence denotes Thus, understanding the mechanisms of NF-κB deregulation by HIV-1 may provide further insights into AIDS pathogenesis.
T25 3790-3928 Sentence denotes In HIV-1 entry, the binding of the gp120 viral envelope to CD4 induces the NF-κB activity by activation of IKK (30) and procaspase 8 (31).
T26 3929-4078 Sentence denotes Following viral integration, the early encoded HIV-1 Tat protein interacts with the HIV-1 RNA and host cell factors to sustain the viral replication.
T27 4079-4328 Sentence denotes Tat binds to RNA stem-loop structures generated by the 5′ end of target transcripts, including the HIV-1 transactivation-responsive element (TAR) (32), tumor necrosis factor β (TNFβ) (33) and interleukin-6 (IL-6) (34) to activate gene transcription.
T28 4329-4591 Sentence denotes Indeed, Tat promotes the transcriptional initiation and elongation by interacting with transacting factors and cofactors, such as Sp1 (35), TFIID (36), E2F-4 (37), C/EBPβ (38), cyclin T1/CDK9 (39,40) and the histone acetyltransferases p300/CBP and P/CAF (41–43).
T29 4592-4774 Sentence denotes When released from HIV-1-infected cells, Tat deregulates the cell signaling by binding to cell receptors, such as integrins (44), Flk1/KDR receptor (45) and chemokine receptors (46).
T30 4775-4886 Sentence denotes We first reported that NF-κB was constitutively active in Jurkat cells that stably expressed the Tat gene (47).
T31 4887-5126 Sentence denotes Following gene transfection or protein transduction, Tat induced the IKK activity and proteasomal degradation of IκB-α (48), and increased the p65 transcriptional activity by inhibiting the SIRT-1-mediated deacetylation of p65 Lys310 (49).
T32 5127-5358 Sentence denotes These findings suggested that Tat modulates crucial enzymes involved in NF-κB signaling; however, it was unclear how Tat could subvert the negative feedback of NF-κB, which is mainly dependent on de novo synthesis of IκB-α (15,17).
T33 5359-5471 Sentence denotes We previously found that IκB-α binds to Tat and promotes the nuclear export of the viral transactivator (50,51).
T34 5472-5684 Sentence denotes In this study, we report that Tat counteracts the post-activation turn off of NF-κB through direct interaction with IκB-α and p65, which enhances the DNA binding and transcriptional activity of the NF-κB complex.
T35 5685-5823 Sentence denotes The new mechanism of NF-κB deregulation here described may provide further insights into the chronic immune activation of HIV-1 infection.
T36 5825-5846 Sentence denotes MATERIALS AND METHODS
T37 5848-5856 Sentence denotes Plasmids
T38 5857-6081 Sentence denotes The plasmids pcDNA-3xHA-IκB-α, p3xFLAG-CMV-Tat, p3xFLAG-CMV-Tat C(22,25,27)A, p3xFLAG-CMV-Tat R(49,52,53,55,56,57)A, pGEX-2T-Tat, pGEX-2T-Tat C(22,25,27)A and pGEX-2T-Tat R(49,52,53,55,56,57)A were previously described (50).
T39 6082-6294 Sentence denotes The plasmids pNL4-3.Luc.R-E- and pHXB2-env were obtained from the AIDS Research & Reference Reagent Program, Division of AIDS, NIAID, NIH, USA; pκBluc and pSV-β-Gal were purchased from Promega (Madison, WI, USA).
T40 6295-6560 Sentence denotes The plasmids pRc/CMV-3xHA-p65, pRc/CMV-3xHA-p65ΔC(1–318), pRc/CMV-3xHA-p65ΔN(122–551), p3xFLAG-CMV-Tat T,N(23,24)A, p3xFLAG-CMV-Tat K(50,51)A, pGEX-2T-Tat T,N(23,24)A, pGEX-2T-Tat K(50,51)A and pNL4-3.FLAG-Tat.R-E- were generated as described in Supplementary Data.
T41 6562-6614 Sentence denotes Cells, transfection, treatments and luciferase assay
T42 6615-6841 Sentence denotes HeLa, p50−/−p65−/− mouse embryonic fibroblasts (MEFs) (52) and 293T cells were cultured in Dulbecco's modified Eagle's medium; Jurkat, U937 cells and human peripheral blood mononuclear cells (PBMCs) were cultured in RPMI 1640.
T43 6842-6891 Sentence denotes PBMCs were isolated as previously described (53).
T44 6892-7008 Sentence denotes Media were supplemented with 10% heat-inactivated fetal calf serum and 2 mM l-glutamine (Lonza Cologne AG, Germany).
T45 7009-7278 Sentence denotes HeLa, p50−/−p65−/− MEFs and 293T were transfected with DNA by using FuGENE HD (Roche Diagnostic GmbH, Mannheim, Germany), according to the manufacturer's protocol; total DNA amounts were equalized by transfection of pRc/CMV empty vector (Invitrogen, Carlsbad, CA, USA).
T46 7279-7567 Sentence denotes For pulse-stimulation, HeLa cells were treated with phorbol 12-myristate 13-acetate (PMA; Sigma-Aldrich, St Louis, MO, USA) (20 ng/ml) for 5 min, or tumor necrosis factor-α (TNF-α; Sigma-Aldrich) (20 ng/ml) for 30 min, washed twice in complete culture medium and then returned to culture.
T47 7568-7671 Sentence denotes For luciferase assays, pSV-β-Gal was co-transfected with pκBluc to monitor the transfection efficiency.
T48 7672-7971 Sentence denotes Forty-eight-hour post-transfection, cells were lysed in lysis buffer of Dual Light Luciferase System (Tropix, Bedford, MA, USA) and the luciferase and β-galactosidase activities were evaluated by using Dual Light Luciferase System (Tropix) in a bioluminometer (Turner Biosystem, Sunnyvale, CA, USA).
T49 7972-8079 Sentence denotes The ratio of firefly luciferase activity to β-galactosidase activity was expressed as relative light units.
T50 8081-8097 Sentence denotes RNA interference
T51 8098-8223 Sentence denotes Jurkat or U937 cells were transfected by electroporation using a Bio-Rad apparatus (Bio-Rad Laboratories, Hercules, CA, USA).
T52 8224-8506 Sentence denotes Briefly, aliquots (5 × 106 cells) were suspended in 0.3 ml of RPMI 1640 supplemented with 20% fetal calf serum and subjected to a double electrical pulse (0.22 V, 960 µF) in the presence of annealed siRNA (200 pmol); electroporated cells were washed and cultured in complete medium.
T53 8507-8726 Sentence denotes RNA interference was performed with: siRNA Tat sense, CUGCUUGUACCAAUUGCUAUU and siRNA Tat antisense, UAGCAAUUGGUACAAGCAGUU; siRNA control sense, CUGCUUGUCACA AUUGCUAUU and siRNA control antisense, UAGCAAUUGUGACAAGCAGUU.
T54 8727-8841 Sentence denotes RNA interference of p65 and IκB-α was performed with SMART pool siRNA p65 and IκB-α (Dharmacon, Chicago, IL, USA).
T55 8843-8889 Sentence denotes Pseudotyped virions and single round infection
T56 8890-9072 Sentence denotes 293T cells (1 × 107) were transfected with pNL4-3.Luc.R-E- or pNL4-3.FLAG-Tat.R-E- (10 µg) together with pHXB2 Env (10 µg), and 48-h post-transfection cell supernatant was collected.
T57 9073-9169 Sentence denotes Enzyme-linked immunosorbent assay (ELISA) using anti-p24 antibody measured virion concentration.
T58 9170-9319 Sentence denotes PBMCs, Jurkat or U937 cells (5 × 107) were infected with HXB2 Env-pseudotyped virions (500 ng of p24) by spinoculation, as previously described (50).
T59 9321-9388 Sentence denotes Cell extracts, western blotting, IKK activity and NF-κB DNA binding
T60 9389-9515 Sentence denotes Total, nuclear and cytosolic extracts were performed as previously described (54); details are reported in Supplementary Data.
T61 9516-10064 Sentence denotes Western blotting analysis was performed by resuspending protein aliquots in loading buffer (125 mM Tris–HCl, pH 6.8, 5% SDS, 1% bromophenol blue, 10% β-mercaptoethanol, 25% glycerol), resolved on 12% SDS–PAGE, transferred to polyvinylidene difluoride membrane (Millipore, Bedford, MA, USA) and incubated with primary antibodies (1:1000) followed by incubation with horseradish-peroxidase-linked mouse or rabbit IgG (1:2000) (GE Healthcare Amersham, Little Chalfont, Buckinghamshire, UK) in PBS containing 5% non-fat dry milk (Bio-Rad Laboratories).
T62 10065-10155 Sentence denotes Proteins were detected by chemiluminescence using the ECL System (GE Healthcare Amersham).
T63 10156-10195 Sentence denotes Primary antibodies were purchased from:
T64 10196-10396 Sentence denotes Santa Cruz Biotechnology, Santa Cruz, CA, USA (anti-HA F7, anti-IκB-α C15, anti-Histone H1, anti-Hexokinase-II); Sigma-Aldrich (anti-FLAG M2, anti-γ-Tubulin); Upstate, Lake Placid, NY, USA (anti-p65).
T65 10397-10477 Sentence denotes Densitometry of single bands was analysed by ImageJ software package (NIH, USA).
T66 10478-10611 Sentence denotes IKK activity was evaluated in cytosolic extracts using the HTScan IKK kinase assay kit (Cell Signaling Technology, Danvers, MA, USA).
T67 10612-10798 Sentence denotes Binding of p65, p50 and FLAG-Tat to the double-stranded NF-κB oligonucleotide was measured using NF-κB Combo Transcription Factor Assay kit (Cayman Chemical Company, Ann Arbor, MI, USA).
T68 10799-10931 Sentence denotes Electrophoretic Mobility Shift Assay (EMSA) was performed as previously described (55); details are described in Supplementary Data.
T69 10933-10953 Sentence denotes In vitro translation
T70 10954-11137 Sentence denotes HA-IκB-α, p65 and Tat were expressed under the T7 promoter and in vitro translated using the TnT quick coupled transcription/translation system (Promega), as previously reported (50).
T71 11138-11182 Sentence denotes Details are described in Supplementary Data.
T72 11184-11227 Sentence denotes Immunoprecipitation assay and GST-pull down
T73 11228-11370 Sentence denotes Immunoprecipitation, GST-pull down, and production of GST proteins in Escherichia coli strain BL21 were performed as previously reported (50).
T74 11371-11415 Sentence denotes Details are described in Supplementary Data.
T75 11417-11430 Sentence denotes Real-time PCR
T76 11431-11681 Sentence denotes Total RNA was extracted from cells by using the TRIzol reagent (Invitrogen); RNA aliquots (200 ng) were reverse transcribed using Random Examers (Roche) and Superscript III Reverse Transcriptase (Invitrogen), according to the manufacturer's protocol.
T77 11682-11878 Sentence denotes Real-time PCR was performed with the iQ Green Super mix (Bio-Rad Laboratories) and carried out with the iCycler iQ Real-Time detection system (Bio-Rad Laboratories) under the following conditions:
T78 11879-11921 Sentence denotes 95°C, 1 min; (94°C, 10 s; 60°C, 30 s) ×40.
T79 11922-11982 Sentence denotes Primers for Tat and MIP-1α are listed in Supplementary Data.
T80 11983-12144 Sentence denotes Real-time PCR of CSF3, LTA, NFKBIA, TLR2, GAPDH and ACTB was performed using the RT2 profiler PCR Array-Human NF-κB signaling pathway (QIAGEN Sciences, MD, USA).
T81 12145-12282 Sentence denotes Reactions were carried out in triplicate, and gene expression levels were calculated relative to GAPDH mRNA levels as endogenous control.
T82 12283-12363 Sentence denotes Relative expression was calculated as 2(Ct gene under investigation − Ct GAPDH).
T83 12365-12400 Sentence denotes Chromatin immunoprecipitation assay
T84 12401-12490 Sentence denotes Cells were fixed by adding formaldehyde (Sigma-Aldrich) at the final concentration of 1%.
T85 12491-12627 Sentence denotes After 10 min, ice-cold PBS plus 0.125 M glycine was added, and plates were transferred on ice, washed extensively with PBS, and scraped.
T86 12628-12806 Sentence denotes After centrifugation, cells were 10 min lysed in lysis buffer (5 mM PIPES pH 8.0, 85 mM KCl, 0.5% NP-40) supplemented with 1× Complete Protease Inhibitor (Roche Diagnostic GmbH).
T87 12807-12929 Sentence denotes Nuclei were pelletted (1000 × g, 5 min), and resuspended in sonication buffer (50 mM Tris–HCl pH 8.0, 1% SDS, 10 mM EDTA).
T88 12930-13194 Sentence denotes Chromatin was sonicated using Bandelin Sonoplus GM70 (Bandelin Electronic, Berlin, Germany), centrifuged (14 000 × g, 15 min), and supernatant was 10-fold diluted in dilution buffer (0.01% SDS, 16.7 mM Tris–HCl pH 8.0, 1.1% Triton X-100, 167 mM NaCl, 1.2 mM EDTA).
T89 13195-13345 Sentence denotes Samples were pre-cleared by 3-h incubation with 20 µl of protein G agarose beads followed by incubation with antibodies against the analysed proteins.
T90 13346-13497 Sentence denotes Primary antibodies were: anti-p65 (sc-372), anti-IκBα (sc-203) and rabbit IgG (sc-2027) from Santa Cruz Biotechnology; anti-FLAG M2 from Sigma–Aldrich.
T91 13498-13944 Sentence denotes Immunoprecipitations were carried out at 4°C overnight and immune complexes were collected with protein G agarose beads, washed five times with low salt buffer (20 mM Tris–HCl pH 8.0, 0.1% SDS, 1% Triton X-100, 2 mM EDTA, 150 mM NaCl), four times with high salt buffer (20 mM Tris–HCl pH 8.0, 0.1% SDS, 1% Triton X-100, 2 mM EDTA, 500 mM NaCl), once with TE buffer (10 mM Tris–HCl pH 8.0, 1 mM EDTA), and extracted in TE buffer containing 2% SDS.
T92 13945-14012 Sentence denotes Protein–DNA cross-links were reverted by heating at 65°C overnight.
T93 14013-14124 Sentence denotes DNA was further purified by QIAquick PCR purification kit (QIAGEN) and eluted in 50 µl sterile distilled water.
T94 14125-14294 Sentence denotes Specific enrichment in NF-κB enhancer sequences was measured by real-time PCR of chromatin immunoprecipitation (ChIP) eluates using SYBR GreenER Master Mix (Invitrogen).
T95 14295-14423 Sentence denotes Reactions were carried out with the iCycler iQ Real-Time detection system (Bio-Rad Laboratories) using the following conditions:
T96 14424-14466 Sentence denotes 95°C, 1 min; (94°C, 10 s; 60°C, 30 s) ×40.
T97 14467-14540 Sentence denotes Primers used for MIP-1α, GAPDH and ACTB are listed in Supplementary Data.
T98 14541-14637 Sentence denotes Real-time PCR of CSF3, LTA, NFKBIA and TLR2 were performed using the Custom ChIP array (QIAGEN).
T99 14638-14746 Sentence denotes For each sample, values were normalized to input DNA and reported as % of input over the rabbit IgG control.
T100 14748-14768 Sentence denotes Statistical analysis
T101 14769-14842 Sentence denotes Statistical analysis was performed by two-tail unpaired Student's t-test.
T102 14843-14876 Sentence denotes Data were reported as means ± SE.
T103 14877-14980 Sentence denotes Differences between the means were considered as statistically significant at the 95% level (P < 0.05).
T104 14982-14989 Sentence denotes RESULTS
T105 14991-15094 Sentence denotes Tat enhances the NF-κB activity by hijacking IκB-α and inhibiting the post-activation turn off of NF-κB
T106 15095-15229 Sentence denotes We analysed the kinetic of NF-κB activation in single round HIV-1 infection by modulating the expression of Tat with RNA interference.
T107 15230-15398 Sentence denotes Jurkat cells were transfected with siRNA Tat, siRNA control, or left untransfected, and 24 h later cells were infected with HXB2 Env-pseudotyped NL4-3.Luc.R−E− virions.
T108 15399-15533 Sentence denotes By cytofluorimetric analysis, ∼40% of cells was siRNA-transfected and HIV-1-infected at 12-h post-infection (Supplementary Figure S1).
T109 15534-15756 Sentence denotes The expression of Tat was detected at 1-h post-infection and progressively increased up to 12 h in untransfected and siRNA control-transfected cells, while it was barely detected in siRNA Tat-transfected cells (Figure 1A).
T110 15757-16051 Sentence denotes The LTR-dependent luciferase expression was also progressively induced at 1- to 12-h post-infection in untransfected and siRNA control-transfected cells, while it was barely observed in siRNA Tat-transfected cells, as expected for the Tat-dependent transactivation of the HIV-1 LTR (Figure 1A).
T111 16052-16061 Sentence denotes Figure 1.
T112 16062-16148 Sentence denotes Tat counteracts the post-activation turn off of NF-κB in single round HIV-1-infection.
T113 16149-16861 Sentence denotes Jurkat cells (5 × 107) were transfected with siRNA Tat or siRNA control (2 nmol), or left untransfected; 24 h later, cells were infected with HXB2-pseudotyped NL4-3.Luc.R−E− virions (500 ng of p24) and harvested at the indicated time. (A) Tat expression was measured in total RNA by real-time PCR, while the luciferase activity was measured in whole cell extracts. (B) Nuclear extracts (10 µg) were analysed for the p65 and p50 binding to the NF-κB double-stranded oligonucleotide using the NF-κB Transcription Factor ELISA Assay kit (Cayman). (C) The expression of p65 and IκB-α was analysed by 12% SDS–PAGE and western blotting of nuclear or cytosolic extracts (20 µg) using anti-p65 and anti-IκB-α antibodies.
T114 16862-16989 Sentence denotes Histone H1 and Hexokinase II were detected with specific antibodies as markers of nuclear and cytosolic extracts, respectively.
T115 16990-17207 Sentence denotes Densitometry values (D) of the bands were expressed as fold increase above the control (mock). (D) IKK activity was measured in cytosolic extracts (100 µg) by using HTScan IKK Kinase Assay (Cell Signaling Technology).
T116 17208-17244 Sentence denotes Values (mean ± SE, n = 3) are shown.
T117 17245-17738 Sentence denotes The progressive increase in NF-κB activity, as measured by p65–p50 binding to an NF-κB consensus oligonucleotide (Figure 1B) and nuclear p65 (Figure 1C, nucleus), was observed at 1- to 3-h post-infection in both Tat-positive (no siRNA or siRNA control) and Tat-negative (siRNA Tat) cells; however, at 12-h post-infection, the p65 DNA binding and nuclear p65 persisted elevated in presence of Tat (no siRNA and siRNA control), while they dropped in absence of Tat (siRNA Tat) (Figure 1B and C).
T118 17739-17942 Sentence denotes IκB-α was degraded in the cytosol within 3-h post-infection and de novo synthesized at 6 h with full replenishment at 12-h post-infection in both Tat-positive and Tat-negative cells (Figure 1C, cytosol).
T119 17943-18094 Sentence denotes Consistently, the IKK activity was induced at 1-h post-infection, and decreased at 3-h post-infection independently of the presence of Tat (Figure 1D).
T120 18095-18360 Sentence denotes Similar kinetics of NF-κB activity, IKK activation and IκB-α degradation/re-synthesis were observed in single-round HIV-1 infection of PBMCs using a cocktail of Azidothymidine (AZT) and Lamivudine (3TC) as reverse transcriptase inhibitors (Supplementary Figure S2).
T121 18361-18659 Sentence denotes These results indicated that in single-round HIV-1 infection the NF-κB activation initially correlated with the IKK activation and IκB-α degradation independently of the presence of Tat, and it was kept elevated in presence of Tat following the decay of the IKK activity and new synthesis of IκB-α.
T122 18660-18749 Sentence denotes Next, we tested the single action of Tat on the kinetic of NF-κB activity induced by PMA.
T123 18750-18942 Sentence denotes To this end, HeLa cells were transfected with p3x-FLAG-Tat, or empty vector, stimulated with PMA for 5 min, and extensively washed to avoid the oscillatory kinetic of NF-κB activation (17,18).
T124 18943-19143 Sentence denotes In un-stimulated cells, the p65 DNA binding (Figure 2A) and nuclear p65 (Figure 2B, nucleus) were slightly enhanced by Tat, while the IκB-α content was not significantly affected (Figure 2B, cytosol).
T125 19144-19491 Sentence denotes Transient stimulation with PMA increased the NF-κB DNA binding activity and nuclear p65 at 5 min peaking at 60–120 min independently of the presence of Tat (Figure 2A and B); however, while the p65 DNA binding and nuclear p65 persisted elevated at 240-min post-treatment in Tat-positive cells, they dropped in Tat-negative cells (Figure 2A and B).
T126 19492-19716 Sentence denotes In addition, Tat bound to the NF-κB oligonucleotide in un-stimulated cells and its binding increased following PMA stimulation (Figure 2A), suggesting that the viral protein was a component of the NF-κB complex bound to DNA.
T127 19717-19913 Sentence denotes Degradation of IκB-α was progressively induced at 5–30 min, followed by de novo synthesis at 60 min with full replenishment at 240 min in both Tat-positive and negative cells (Figure 2B, cytosol).
T128 19914-20039 Sentence denotes Consistently, the IKK activation started at 5 min, and turned off at 30 min independently of the presence of Tat (Figure 2C).
T129 20040-20196 Sentence denotes These results indicated that Tat enhanced the NF-κB activity in un-stimulated and PMA-stimulated cells without affecting the IKK activity and IκB-α content.
T130 20197-20206 Sentence denotes Figure 2.
T131 20207-20330 Sentence denotes Tat enhances the NF-κB activity following PMA stimulation by associating with IκB-α and counteracting the NF-κB repression.
T132 20331-20558 Sentence denotes HeLa cells (5 × 106) were transfected with p3xFLAG-Tat or p3xFLAG empty vector (5 µg), and 48 h later were stimulated with PMA (5 min, 20 ng/ml) or left unstimulated, washed twice with DMEM and harvested at the indicated times.
T133 20559-21007 Sentence denotes Nuclear and cytosolic extracts were prepared for further analysis. (A) Nuclear extracts were analysed for the p65, p50 and FLAG-Tat binding to the NF-κB double-stranded oligonucleotide using the NF-κB Transcription Factor ELISA assay kit (Cayman). (B) Nuclear and cytosolic extracts (20 µg) were separated by 12% SDS–PAGE and analysed by western blotting using the anti-p65, anti-FLAG, anti-Histone H1, anti-IκB-α and anti-Hexokinase-II antibodies.
T134 21008-21441 Sentence denotes Densitometry values (D) of the bands were expressed as fold increase above the control (lane 1). (C) IKK activity was measured in cytosolic extracts (100 µg) by using HTScan IKK kinase assay (Cell Signaling Technology). (D) HeLa cells (5 × 106) were transfected with or without p3xFLAG-Tat (5 µg); 48 h later, cells were stimulated with PMA (5 min, 20 ng/ml) or left unstimulated, washed twice with DMEM, and harvested after 240 min.
T135 21442-21546 Sentence denotes Whole cell extracts (1 mg) were immunoprecipitated with protein G-Sepharose-coupled anti-IκB-α antibody.
T136 21547-21678 Sentence denotes Immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-p65, anti-FLAG and anti-IκB-α antibodies.
T137 21679-21775 Sentence denotes Densitometry values (D) of the bands were expressed as fold increase above the control (lane 1).
T138 21776-21812 Sentence denotes Values (mean ± SE, n = 3) are shown.
T139 21813-21967 Sentence denotes As we previously found that Tat binds to the sixth ankyrin of IκB-α (50,51), we tested whether Tat counteracted the generation of the IκB-α/NF-κB complex.
T140 21968-22195 Sentence denotes To this end, the association of IκB-α with p65 was analysed in vivo at 0 and 240 min after short-pulse PMA, which corresponded to the time of un-stimulated condition and post-activation de novo synthesis of IκB-α, respectively.
T141 22196-22494 Sentence denotes Coimmunoprecipitation of IκB-α with p65 was detected at 0- and 240-min post-treatment in Tat-negative cells (Figure 2D, lanes 1 and 3), and was halved in Tat-positive cells, where Tat coimmunoprecipitated with IκB-α (Figure 2D, lanes 2 and 4), indicating that Tat competed the IκB-α binding to p65.
T142 22496-22574 Sentence denotes Tat counteracts the IκB-α inhibition of p65 by competing the repressor binding
T143 22575-22709 Sentence denotes We further investigated the physical interaction of Tat with IκB-α using in vitro translated proteins in coimmunoprecipitation assays.
T144 22710-22781 Sentence denotes For mapping the interaction domains, we used the following Tat mutants:
T145 22782-22861 Sentence denotes Tat T,N(23,24)A, Tat C(22,25,27)A, Tat K(50,51)A and Tat R(49–57)A (Figure 3A).
T146 22862-22945 Sentence denotes IκB-α coimmunoprecipitated with all Tat proteins, except Tat R(49–57)A (Figure 3B).
T147 22946-23101 Sentence denotes These results indicated that the arginine-rich domain of Tat was involved in the binding to IκB-α, which was consistent with previous observations (50,51).
T148 23102-23389 Sentence denotes Moreover, Tat associating with IκB-α competed the binding of IκB-α to p65 in a dose-dependent manner (Figure 3C, lanes 3–5), while Tat R(49–57)A, which lacked the binding site for IκB-α, did not associate with IκB-α and did not compete the binding of IκB-α to p65 (Figure 3C, lanes 6–8).
T149 23390-23399 Sentence denotes Figure 3.
T150 23400-23710 Sentence denotes Tat relieves p65 from the IκB-α inhibition. (A) Schematic representation of wild-type and mutant Tat proteins. (B) HA-IκB-α (5 µl) was incubated in presence or absence of FLAG-Tat, FLAG-Tat T,N(23,24)A, FLAG-Tat K(50,51)A, FLAG-Tat R(49–57)A or FLAG-Tat C(22,25,27)A (10 µl) using in vitro translated proteins.
T151 23711-24080 Sentence denotes Wild-type and mutant Tat proteins were immunoprecipitated with anti-FLAG antibody; immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-HA and anti-FLAG antibodies. (C) 35S-methionine-labeled p65 (5 µl) was incubated with in vitro translated HA-IκB-α (5 µl) in presence or absence of FLAG-Tat or FLAG-Tat R(49–57)A (5, 10 or 20 µl).
T152 24081-24288 Sentence denotes HA-IκB-α was immunoprecipitated with anti-HA antibody; immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-HA and anti-FLAG antibodies, or autoradiography (35S-Met-p65).
T153 24289-24475 Sentence denotes Densitometry values (D) of the bands were expressed as fold increase above the control (lane 1). (D) The p65 DNA binding activity was analysed by EMSA using in vitro translated proteins.
T154 24476-24777 Sentence denotes 32P-labeled-NF-κB double-stranded oligonucleotide was incubated with p65 (0.5 µl) in presence or absence of HA-IκB-α (1 µl), FLAG-Tat or FLAG-Tat R(49–57)A (5 and 10 µl); competition of DNA binding was performed with 10 - up to 100-fold molar excess of unlabeled NF-κB double-stranded oligonucleotide.
T155 24778-25073 Sentence denotes DNA/protein complexes were run on 6% PAGE–TBE and analysed by autoradiography. (E) p50−/−p65−/−MEFs (3 × 105 cells) were transfected with pκBLuc (0.5 µg) and pSV-β-Gal (0.1 µg) with or without pRc/CMV-p65 (0.5 µg), pCMV4-HA-IκB-α (0.5 µg), p3xFLAG-Tat or p3xFLAG-Tat R(49–57)A (0.5, 1 and 2 µg).
T156 25074-25194 Sentence denotes The luciferase activity was measured in cell extracts 48-h post-transfection and normalized to β-galactosidase activity.
T157 25195-25279 Sentence denotes Fold activation was calculated relative to transfection of the pκBLuc plasmid alone.
T158 25280-25316 Sentence denotes Values (mean ± SE, n = 3) are shown.
T159 25317-25483 Sentence denotes As control of protein expression, aliquots of cell extracts (20 µg) were analysed by western blotting with anti-p65, anti-HA, anti-FLAG and anti-γ-tubulin antibodies.
T160 25484-25705 Sentence denotes Next, we evaluated whether Tat counteracted the IκB-α-mediated inhibition of p65 binding to DNA by incubating in vitro translated p65 and IκB-α proteins with the NF-κB probe in presence or absence of Tat followed by EMSA.
T161 25706-25852 Sentence denotes The p65 DNA binding activity was inhibited by IκB-α and restored in a dose-dependent manner by wild-type Tat, and not by Tat R(49–57) (Figure 3D).
T162 25853-26087 Sentence denotes Further, we analysed the Tat effect on the IκB-α repression of p65 transcriptional activity by transfecting p50−/−p65−/−MEFs with the NF-κB-Luc reporter together with expression vectors of p65 and IκB-α, in presence or absence of Tat.
T163 26088-26258 Sentence denotes IκB-α inhibited the p65-dependent expression of the luciferase gene, which was restored in a dose-dependent manner by wild-type Tat, and not by Tat R(49–57)A (Figure 3E).
T164 26259-26457 Sentence denotes Altogether these results indicated that Tat counteracts the IκB-α repression of the p65 DNA-binding and transcriptional activity by associating with IκB-α and competing the repressor binding to p65.
T165 26459-26533 Sentence denotes Tat increases the p65 affinity binding to DNA through association with p65
T166 26534-26587 Sentence denotes We tested whether Tat physically interacted with p65.
T167 26588-26729 Sentence denotes HeLa cells were transfected with the expression vectors of HA-p65 and FLAG-Tat, and 24 h later Tat was immunoprecipitated from cell extracts.
T168 26730-26973 Sentence denotes The p65 protein was coimmunoprecipitated with wild-type Tat or the mutants Tat T,N(23,24)A, Tat K(50,51)A and Tat R(49–57)A at similar levels, while a significant decrease in coimmunoprecipitation was observed for Tat C(22,25,27)A (Figure 4A).
T169 26974-27202 Sentence denotes Consistently, GST-pull down of in vitro translated proteins showed the direct binding of p65 to wild-type Tat, or the mutants Tat T,N(23,24)A, Tat K(50,51)A and Tat R(49–57)A, and lack of binding to Tat C(22,25,27)A (Figure 4B).
T170 27203-27368 Sentence denotes These results indicated that Tat associated with p65 through the cysteine-rich domain and ruled-out the requirement of bridging proteins to mediate such interaction.
T171 27369-27378 Sentence denotes Figure 4.
T172 27379-27646 Sentence denotes Tat associates with p65 increasing its DNA-affinity binding. (A) HeLa cells were transfected with pRc/CMV-3xHA-p65 (5 µg) in presence or absence of p3xFLAG-Tat, p3xFLAG-Tat T,N(23,24)A, p3xFLAG-Tat K(50,51)A, p3xFLAG-Tat R(49–57)A, or p3xFLAG-Tat C(22,25,27)A (5 µg).
T173 27647-28028 Sentence denotes FLAG-Tat proteins were immunoprecipitated with anti-FLAG antibody; immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-FLAG or anti-HA antibodies. (B) In vitro translated p65 (5 µl) was incubated with GST-Tat, GST-Tat T,N(23,24)A, GST-Tat K(50,51)A, GST-Tat R(49–57)A, GST-Tat C(22,25,27)A, or GST (5 µg) conjugated with Glutathione-Sepharose.
T174 28029-28416 Sentence denotes Protein complexes were recovered by GST-pull down, separated by 12% SDS–PAGE, and analysed by western blotting with anti-p65 or anti-GST antibodies. (C) Schematic representation of wild-type and mutant p65 proteins. (D) HeLa cells were transfected with p3xFLAG-Tat (5 µg) in the presence or absence of pRc/CMV-3xHA-p65, pRc/CMV-3xHA-p65ΔC (1–318), or pRc/CMV-3xHA-p65ΔN (122–551) (5 µg).
T175 28417-28947 Sentence denotes Wild-type and mutant HA-p65 proteins were immunoprecipitated with anti-HA antibody; immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-FLAG or anti-HA antibodies. (E) Recombinant p65 protein (100 ng; Active Motif Carlsbad, CA, USA) was 20 min incubated with 32P-labeled NF-κB double-stranded oligonucleotide in presence or absence of in vitro translated FLAG-Tat or FLAG-Tat C(22,25,27)A (5 µl); competitions were performed with 1.25- up to 40-fold molar excess of unlabeled oligonucleotide.
T176 28948-29092 Sentence denotes DNA/protein complexes were separated by 6% PAGE in 0.5 × TBE buffer and analysed by autoradiography. (F) Densitometry of band-shifts shown in E.
T177 29093-29328 Sentence denotes To identify the p65 domain required for binding to Tat, HeLa cells were transfected with FLAG-Tat together with HA-p65 mutants, which were deleted of the transactivation domain [p65ΔC (1–318)], or the RHD [p65ΔN (122–551)] (Figure 4C).
T178 29329-29497 Sentence denotes Tat coimmunoprecipitated with p65ΔC (1–318), and not with p65ΔN (122–551) (Figure 4D), indicating that the RHD of p65 was involved in the physical interaction with Tat.
T179 29498-29764 Sentence denotes To address the effect of Tat on the p65 DNA-binding affinity, purified recombinant p65 protein was incubated with 32P-labeled-NF-κB double-stranded oligonucleotide in presence or absence of wild-type Tat or Tat C(22,25,27)A, and p65 DNA-binding was analysed by EMSA.
T180 29765-29929 Sentence denotes Whereas wild-type Tat significantly increased the binding of p65 to DNA, the mutant Tat C(22,25,27)A, lacking the binding site for p65, was ineffective (Figure 4E).
T181 29930-30143 Sentence denotes The p65 binding to DNA was evaluated by competition with increasing amounts of cold competitor NF-κB oligonucleotide, which showed that Tat significantly enhanced the p65 affinity binding to DNA (Figure 4E and F).
T182 30145-30300 Sentence denotes Tat activates the p65-dependent expression of NF-κB-responsive genes, occupies the NF-κB enhancers and promotes the p65 recruitment with IκB-α displacement
T183 30301-30383 Sentence denotes We analysed the action of Tat on the expression of NF-κB-responsive genes in vivo.
T184 30384-30582 Sentence denotes To this end, HeLa cells were transfected with FLAG-Tat, FLAG-Tat C(22,25,27)A or FLAG-Tat R(49–57)A, and 48 h later the expression of a number of NF-κB-dependent genes was analysed by real-time PCR.
T185 30583-30749 Sentence denotes Tat significantly increased the expression of MIP-1α, CSF3, LTA, NFKBIA and TLR2, while the mutants Tat C(22,25,27)A and Tat R(49–57)A were ineffective (Figure 5A–E).
T186 30750-30956 Sentence denotes The Tat-dependent transactivation of the NF-κB-dependent genes was abolished when cells were transfected with siRNA p65, indicating that the Tat transcriptional activation was mediated by p65 (Figure 5A–E).
T187 30957-31093 Sentence denotes Differently, the expression of the NF-κB-independent genes GAPDH and ACTB was unaffected by wild-type and Tat mutants (Figure 5F and G).
T188 31094-31383 Sentence denotes These results were consistent with the requirement of both the cysteine-rich and arginine-rich domains of Tat to enhance the NF-κB activity, suggesting that the up-regulation of NF-κB-responsive genes by Tat might occur through physical interaction of the viral protein with p65 and IκB-α.
T189 31384-31393 Sentence denotes Figure 5.
T190 31394-31554 Sentence denotes Tat activates the p65-dependent expression of NF-κB-responsive genes by occupying the NF-κB enhancers and promoting the p65 recruitment with IκB-α displacement.
T191 31555-31808 Sentence denotes HeLa cells (5 × 106) were transfected with p3xFLAG-Tat, p3xFLAG-Tat C(22,25,27), p3xFLAG-Tat R(49–57) or empty vector (10 µg); for p65 RNA interference, cells (5 × 106) were transfected with p3xFLAG-Tat (10 µg) and siRNA p65 or siRNA control (200 pmol).
T192 31809-32150 Sentence denotes Twenty-four-hour post-transfection, total RNA was extracted and analysed by real-time PCR to evaluate the expression of MIP-1α (A), CSF3 (B), LTA (C), NFKBIA (D), TLR2 (E), GAPDH (F), ACTB (G) genes. (H) HeLa cells (5 × 106) were transfected with p3xFLAG-Tat, or empty vector (10 µg) and 48 h later ChIP was performed with anti-p65 antibody.
T193 32151-32435 Sentence denotes Real-time PCR was performed with primers specific for the indicated promoters. (I) HeLa cells (5 × 106) were transfected with empty vector, or p3xFLAG-Tat (10 µg) in presence or absence of siRNA p65, or siRNA control (200 pmol); 48 h later, ChIP was performed with anti-FLAG antibody.
T194 32436-32715 Sentence denotes Real-time PCR was performed with primers specific for the indicated promoters. (J) HeLa cells (5 × 106) were transfected with empty vector, p3xFLAG-Tat (10 µg), or empty vector plus siRNA IκB-α or siRNA control (200 pmol); 48 h later, ChIP was performed with anti-IκB-α antibody.
T195 32716-32794 Sentence denotes Real-time PCR was performed with primers specific for the indicated promoters.
T196 32795-32831 Sentence denotes Values (mean ± SE, n = 3) are shown.
T197 32832-32977 Sentence denotes The asterisks indicate statistically significant differences compared to the control (empty vector) according to the Student's t-test (P < 0.05).
T198 32978-33115 Sentence denotes MIP-1α, which was the mostly activated gene by Tat, encodes for a chemokine that promotes the recruitment of pro-inflammatory cells (56).
T199 33116-33331 Sentence denotes Consistently with our findings, MIP-1α expression was increased in glial cells and lymph nodes of AIDS patients (57,58); moreover, MIP-1α production was induced by HIV-1 infection (59,60) and Tat protein (57,61,62).
T200 33332-33403 Sentence denotes The transcriptional regulation of MIP-1α has been poorly characterized.
T201 33404-33669 Sentence denotes Jaspar-based analysis (http://jaspar.genereg.net/) predicted three putative NF-κB enhancers in the proximal promoter region of the MIP-1α gene: NF-κB1, −1023/−1014 nucleotides; NF-κB2, −661/−652 nucleotides; NF-κB3, +370/+379 nucleotides (Supplementary Figure S3A).
T202 33670-33917 Sentence denotes To validate the predicted NF-κB binding sites of the MIP-1α promoter, we stimulated HeLa cells with TNF-α, a well-known NF-κB inducer, and measured the expression levels of MIP-1α by real-time PCR, and the p65 occupancy of the NF-κB sites by ChIP.
T203 33918-34127 Sentence denotes TNF-α activated the expression of MIP-1α and induced the p65 recruitment to the NF-κB1 site of MIP-1α without affecting the occupancy of the putative NF-κB2 and NF-κB3 sites (Supplementary Figure S3B and S3C).
T204 34128-34287 Sentence denotes Tat also promoted the recruitment of p65 to the NF-κB1 site of MIP-1α, while it did not affect the putative NF-κB2 and NF-κB3 sites (Supplementary Figure S3D).
T205 34288-34434 Sentence denotes Altogether these results indicated that the NF-κB1 site was the only effective NF-κB enhancer of the MIP-1α promoter in response to TNF-α and Tat.
T206 34435-34619 Sentence denotes Similarly to MIP-1α, Tat increased the recruitment of p65 to the NF-κB enhancers of CSF3, LTA, NFKBIA and TLR2, while it was ineffective at the promoters of GAPDH and ACTB (Figure 5H).
T207 34620-34839 Sentence denotes By ChIP, Tat bound to the NF-κB-responsive promoters, and not to the GAPDH and ACTB promoters, with loss of binding following p65 RNA interference (Figure 5I), suggesting that Tat occupancy occurred via p65 interaction.
T208 34840-35098 Sentence denotes As additional findings, IκB-α was chromatin-immunoprecipitated at the NF-κB enhancers in absence of Tat, and it was significantly removed in presence of Tat, or following IκB-α RNA interference (Figure 5J), indicating that Tat displaced IκB-α from promoters.
T209 35100-35247 Sentence denotes In HIV-1-infected monocytes Tat sustains the NF-κB activity and promotes the transcriptional activation of MIP-1α by interacting with IκB-α and p65
T210 35248-35367 Sentence denotes We next analysed whether Tat affected the NF-κB activity and the expression of MIP-1α in the course of HIV-1 infection.
T211 35368-35536 Sentence denotes To detect the Tat protein, we produced HXB2 Env-pseudotyped NL4-3.FLAG-Tat.R−E− virions, which were used in single-round infection of U937, a human monocytic cell line.
T212 35537-35724 Sentence denotes Cells were transfected with siRNA Tat, siRNA control or left untransfected to modulate the Tat expression, and then analysed for the kinetic of NF-κB activation following viral infection.
T213 35725-35870 Sentence denotes The expression of Tat and p24 was detected at 3- to 12-h post-infection, while it was barely detected in siRNA Tat-transfected cells (Figure 6A).
T214 35871-35880 Sentence denotes Figure 6.
T215 35881-36002 Sentence denotes In HIV-1 infection Tat sustains the NF-κB activity and enhances the MIP-1α expression via interaction with IκB-α and p65.
T216 36003-36655 Sentence denotes U937 cells (5 × 107) were transfected with siRNA Tat, siRNA control (2 nmol), or left untransfected; 24 h later cells were infected with HXB2-pseudotyped NL4-3.FLAG-Tat.R−E− virions (500 ng of p24) and harvested at the indicated time. (A) Real-time PCR of total RNA measured the Tat expression; ELISA measured the amount of p24 in whole cell extracts. (B) The binding of p65 to the NF-κB double-stranded oligonucleotide was measured in nuclear extracts (10 µg) using the NF-κB Transcription Factor ELISA assay kit (Cayman). (C) The IκB-α content was analysed by 12% SDS–PAGE and western blotting of cytosolic extracts (20 µg) using anti-IκB-α antibody.
T217 36656-36985 Sentence denotes Densitometry values (D) of the bands were expressed as fold increase above the control (mock). (D) IKK activity was measured in cytosolic cell extracts (100 µg) using HTScan IKK Kinase Assay (Cell Signaling Technology). (E) U937 cells (5 × 107) were infected with HXB2-pseudotyped NL4-3.FLAG-Tat.R−E− virions, or left uninfected.
T218 36986-37116 Sentence denotes Twenty-four-hour post-infection, cell extracts (1 mg) were immunoprecipitated with protein G-Sepharose-coupled anti-FLAG antibody.
T219 37117-37467 Sentence denotes Immunocomplexes were separated by 12% SDS–PAGE and analysed by western blotting with anti-p65, anti-FLAG and anti-IκB-α antibodies. (F) U937 cells (5 × 107) were transfected with siRNA Tat, siRNA p65, siRNA control (2 nmol), or left untransfected; 24 h later, cells were infected with HXB2-pseudotyped NL4-3.FLAG-Tat.R−E− virions, or left uninfected.
T220 37468-37779 Sentence denotes Twenty-four-hour post-infection, total RNA was analysed for MIP-1α expression by real-time PCR. (G and H) U937 cells (5 × 107) were transfected with siRNA Tat or siRNA control (2 nmol), or left untransfected; 24 h later, cells were infected with HXB2-pseudotyped NL4-3.FLAG-Tat.R−E− virions, or left uninfected.
T221 37780-37867 Sentence denotes Twenty-four-hour post-infection, ChIP was performed with anti-p65 (G) or anti-FLAG (H).
T222 37868-37949 Sentence denotes Real-time PCR was performed with primers specific for MIP-1α and GAPDH promoters.
T223 37950-37986 Sentence denotes Values (mean ± SE, n = 3) are shown.
T224 37987-38125 Sentence denotes The asterisks indicate statistically significant differences compared to the control (mock), according to the Student's t-test (P < 0.05).
T225 38126-38359 Sentence denotes The NF-κB activity, as measured by p65 DNA binding, was induced at 3-h post-infection in both Tat-positive (no siRNA and siRNA control) and Tat-negative cells (siRNA Tat), and increased at 12 h only in Tat-positive cells (Figure 6B).
T226 38360-38518 Sentence denotes Degradation of IκB-α was observed at 3-h post-infection, and was followed by de novo synthesis of IκB-α at 12 h independently of the Tat presence (Figure 6C).
T227 38519-38653 Sentence denotes Consistently, the IKK activity was induced at 3-h post-infection and turned off at 12 h independently of the Tat presence (Figure 6D).
T228 38654-38882 Sentence denotes These results agreed with the kinetic of NF-κB activation in single-round HIV-1 infection of Jurkat cells (Figure 1), and further supported the requirement of viral expression to counteract the post-activation turn off of NF-κB.
T229 38883-39136 Sentence denotes In HIV-1-infected U937 cells, the endogenous Tat was coimmunoprecipitated with IκB-α and p65 (Figure 6E), and activated the MIP-1α expression in a p65-dependent manner, as shown by the lack of effect following RNA interference of Tat or p65 (Figure 6F).
T230 39137-39281 Sentence denotes Moreover, Tat and p65 were both recruited to the NF-κB enhancer of MIP-1α, while the p65 occupancy was abolished by siRNA Tat (Figure 6G and H).
T231 39282-39525 Sentence denotes Altogether these results indicated that in single round HIV-1 infection Tat associated with IκB-α and p65, and induced the p65-dependent activation of MIP-1α expression through occupancy of the MIP-1α promoter and increased recruitment of p65.
T232 39527-39537 Sentence denotes DISCUSSION
T233 39538-39627 Sentence denotes This study reports a novel mechanism of NF-κB activation by the HIV-1 Tat transactivator.
T234 39628-39901 Sentence denotes Based on the evidence that Tat enhanced the transcriptional activity of the p65 subunit of NF-κB (49,63,64), and physically interacted with the IκB-α repressor (50,51), we investigated the possibility that Tat could activate NF-κB via direct interaction with IκB-α and p65.
T235 39902-40033 Sentence denotes To this end, the NF-κB activity was monitored in single round HIV-1 infection using RNA interference to silence the Tat expression.
T236 40034-40186 Sentence denotes By this approach, we avoided the perpetuation of NF-κB activation signaling due to subsequent rounds of viral entry in cell culture propagation (30,31).
T237 40187-40323 Sentence denotes Upon HIV-1 infection, the early NF-κB activation occurred concomitantly with IKK activation and IκB-α degradation in the absence of Tat.
T238 40324-40512 Sentence denotes Soon after the shut off of IKK activity and new synthesis of IκB-α, the NF-κB activity was kept elevated in the presence of Tat, while it was down regulated upon silencing of the Tat gene.
T239 40513-40669 Sentence denotes These findings indicate that in single round HIV-1 infection, Tat enhanced the NF-κB activity without affecting the IKK activity and the half-life of IκB-α.
T240 40670-40867 Sentence denotes Similar kinetic of NF-κB activation occurred upon short-pulse of PMA in Tat-transfected HeLa cells, where Tat inhibited the post-activation turn off of NF-κB in presence of newly synthesized IκB-α.
T241 40868-41033 Sentence denotes The Tat-dependent activation of NF-κB correlated with the association of the viral protein with IκB-α, which interfered with the generation of the IκB-α/p65 complex.
T242 41034-41153 Sentence denotes This evidence demonstrated that Tat competed for the binding of IκB-α to p65 and prevented the IκB-α repression of p65.
T243 41154-41490 Sentence denotes As additional mechanism of NF-κB activation, Tat associated with p65 and increased the p65 binding affinity to the NF-κB enhancer; this evidence was obtained with recombinant proteins indicating that the stronger binding of p65 to DNA was a consequence of direct association with Tat, which likely caused a conformational change of p65.
T244 41491-41627 Sentence denotes We also demonstrated that the Tat cysteine-rich sequence (C22,25,27) was involved in the binding to the RHD of p65 and NF-κB activation.
T245 41628-41809 Sentence denotes Differently, the Tat arginine-rich sequence (R49,52,53,55,56,57) was required for the binding to the sixth ankyrin of IκB-α (50,51), and for releasing p65 from the IκB-α inhibition.
T246 41810-42018 Sentence denotes Altogether these results demonstrated that Tat abolished the negative feedback regulation of NF-κB by hijacking the IκB-α repressor, shielding p65 from the IκB-α embrace, and enforcing the p65 binding to DNA.
T247 42019-42282 Sentence denotes Further evidence of Tat activation of NF-κB showed that wild-type Tat, and not the Tat mutants lacking the arginine- or cysteine-rich domains, up-regulated in vivo the expression of a number of NF-κB-responsive genes, including MIP-1α, CSF3, LTA, NFKBIA and TLR2.
T248 42283-42438 Sentence denotes By ChIP analysis, we observed that Tat increased the recruitment of p65 to the NF-κB enhancers of the activated genes, and was recovered at the same sites.
T249 42439-42585 Sentence denotes RNA interference of p65 abolished the Tat occupancy of the NF-κB enhancers indicating that the Tat binding to the NF-κB sites was mediated by p65.
T250 42586-42785 Sentence denotes These results were consistent with the evidence that Tat displaced p65 from the binding to IκB-α (Figures 2D and 3C), and increased the p65 DNA binding affinity through association (Figure 4E and F).
T251 42786-42962 Sentence denotes Thus, Tat likely increased the recruitment of p65 to the NF-κB-dependent promoters by associating with p65 and by interfering with the assembly of p65 with the repressor IκB-α.
T252 42963-43087 Sentence denotes Of interest, IκB-α was found associated to the NF-κB enhancers in absence of Tat, where it was displaced in presence of Tat.
T253 43088-43205 Sentence denotes These results suggest a negative regulatory role of IκB-α in gene regulation through occupancy of specific promoters.
T254 43206-43412 Sentence denotes Indeed, IκB-α was found associated with hystone deacetylases at the hes1 promoter, from where it was removed following TNF-α stimulation causing histone acetylation and hes1 transcriptional activation (65).
T255 43413-43621 Sentence denotes A similar mechanism of gene regulation could apply to the NF-κB-dependent genes analysed in this study, where Tat could activate the gene expression by removing IκB-α and promoting the p65 loading (Figure 7).
T256 43622-43631 Sentence denotes Figure 7.
T257 43632-44044 Sentence denotes Model of MIP-1α transcriptional activation by HIV-1 Tat. (A) In absence of Tat, IκB-α occupies the NF-κB enhancer of the MIP-1α promoter and likely interacts with transcriptional repressors, such as HDACs (65), to inhibit gene transcription. (B) Tat activates the MIP-1α expression by removing the IκB-α repressor from the NF-κB enhancer, and by increasing the binding of p65 NF-κB complex to the NF-κB enhancer.
T258 44045-44541 Sentence denotes The physiological relevance of Tat cross talk with NF-κB was demonstrated in the HIV-1 infection of human monocytes, where HIV-1-encoded Tat protein counteracted post-activation turn off of NF-κB, as shown by: (i) sustained NF-κB activity by Tat in presence of newly synthesized IκB-α; (ii) coimmunoprecipitation of Tat with IκB-α and p65; (iii) induction of MIP-1α expression dependent on Tat and p65; (iv) Tat occupancy of the MIP-1α NF-κB enhancer associated with increased recruitment of p65.
T259 44542-44645 Sentence denotes This study supports the pro-inflammatory action of Tat through physical interaction with p65 and IκB-α.
T260 44646-44832 Sentence denotes Several inflammatory cytokines under the transcriptional control of NF-κB are hyper-expressed in HIV-1 infected individuals, including IL-6 (66,67), TNF-α (68), and MIP-1α (57–62,69–71).
T261 44833-45025 Sentence denotes In the case of TNF-α and IL-6, Tat activated the cytokine expression by binding to the TAR-like stem loop of the 5′ transcript, thus likely promoting the transcriptional elongation (33,37,47).
T262 45026-45245 Sentence denotes Here, we have shown that the Tat-dependent transcriptional activation of a number of pro-inflammatory genes required the assembly of Tat with p65 at the NF-κB enhancer together with the displacement of IκB-α (Figure 5).
T263 45246-45467 Sentence denotes Thus, in the set of distinct NF-κB-responsive genes, Tat acted as a component of the transcriptional initiation complex, which is consistent with previous reports on Tat promoting the transcription via DNA motifs (72,73).
T264 45468-45612 Sentence denotes Overproduction of pro-inflammatory cytokines is considered a major mechanism of immune deregulation (26) and neuron dysfunction in AIDS (74,75).
T265 45613-45803 Sentence denotes In this scenario, inhibition of NF-κB activity could lead to a therapeutic strategy for counteracting the abnormal production of pro-inflammatory cytokines and chemokines in HIV-1 infection.
T266 45804-46069 Sentence denotes NF-κB inhibitors, such as anti-oxidants, proteasome and IKK inhibitors, significantly reduced the HIV-1 replication and the associated inflammatory response (76,77); however, these NF-κB inhibitors acted indiscriminately in both HIV-1-infected and uninfected cells.
T267 46070-46232 Sentence denotes The evidence that Tat activates NF-κB through direct interaction with IκB-α and p65 may lead to specific inhibitors to counteract the Tat pro-inflammatory action.
T268 46234-46252 Sentence denotes SUPPLEMENTARY DATA
T269 46253-46300 Sentence denotes Supplementary Data are available at NAR Online:
T270 46301-46367 Sentence denotes Supplementary Figures 1–3 and Supplementary Materials and Methods.
T271 46369-46376 Sentence denotes FUNDING
T272 46377-46654 Sentence denotes Istituto Superiore di Sanità-National Research Program on AIDS (Grant number 40C.77 to I.Q.); Ministero dell'Istruzione, dell'Università e della Ricerca (Grant number FIRB RBLA033WJX_006 to I.Q.); EUROPRISE (Grant number LSHP-CT-2006-037611 to G.S.); FIRC fellowship (to A.R.).
T273 46655-46732 Sentence denotes Funding for open access charge: EUROPRISE (grant number LSHP-CT-2006-037611).
T274 46733-46764 Sentence denotes Conflict of interest statement.
T275 46765-46779 Sentence denotes None declared.
T276 46781-46803 Sentence denotes Supplementary Material
T277 46804-46822 Sentence denotes Supplementary Data

ICD10

Id Subject Object Predicate Lexical cue
T638 6-22 http://purl.bioontology.org/ontology/ICD10/D84.9 denotes immunodeficiency
T639 205-221 http://purl.bioontology.org/ontology/ICD10/D84.9 denotes immunodeficiency
T3222 3143-3159 http://purl.bioontology.org/ontology/ICD10/D84.9 denotes immunodeficiency
T3223 3501-3517 http://purl.bioontology.org/ontology/ICD10/D84.9 denotes immunodeficiency
T18695 35708-35723 http://purl.bioontology.org/ontology/ICD10/B34.9 denotes viral infection

events-check-again

Id Subject Object Predicate Lexical cue Negation Speculation
T881 895-904 Positive_regulation denotes activated
T883 916-926 Gene_expression denotes expression
T884 932-935 Protein denotes p65
T885 936-945 Positive_regulation denotes dependent
T886 958-963 Binding denotes bound
T887 971-977 Protein denotes MIP-1α
T888 978-992 Entity denotes NF-κB enhancer
T889 998-1007 Positive_regulation denotes promoting
T890 998-1007 Positive_regulation denotes promoting
T891 1012-1023 Binding denotes recruitment
T892 1027-1030 Protein denotes p65
T893 1036-1048 Binding denotes displacement true
T894 1052-1057 Protein denotes IκB-α
T895 1121-1125 Protein denotes CSF3
T896 1127-1130 Protein denotes LTA
T897 1132-1138 Protein denotes NFKBIA
T898 1143-1147 Protein denotes TLR2
T899 1220-1231 Binding denotes interaction
T900 1235-1238 Protein denotes Tat
T901 1244-1249 Protein denotes IκB-α
T902 1254-1257 Protein denotes p65
T3998 1543-1547 Protein denotes RelA
T3999 1548-1551 Protein denotes p65
T4000 1553-1558 Protein denotes c-Rel
T4001 1560-1564 Protein denotes RelB
T4002 1566-1569 Protein denotes p50
T4003 1574-1577 Protein denotes p52
T4004 1623-1642 Entity denotes Rel homology domain
T4005 1649-1652 Positive_regulation denotes for
T4006 1649-1652 Positive_regulation denotes for
T4007 1649-1652 Positive_regulation denotes for
T4008 1649-1652 Positive_regulation denotes for
T4009 1649-1652 Positive_regulation denotes for
T4010 1649-1652 Positive_regulation denotes for
T4011 1649-1652 Positive_regulation denotes for
T4012 1649-1652 Positive_regulation denotes for
T4013 1649-1652 Positive_regulation denotes for
T4014 1649-1652 Positive_regulation denotes for
T4015 1649-1652 Positive_regulation denotes for
T4016 1649-1652 Positive_regulation denotes for
T4017 1649-1652 Positive_regulation denotes for
T4018 1649-1652 Positive_regulation denotes for
T4019 1649-1652 Positive_regulation denotes for
T4020 1649-1652 Positive_regulation denotes for
T4021 1649-1652 Positive_regulation denotes for
T4022 1649-1652 Positive_regulation denotes for
T4023 1649-1652 Positive_regulation denotes for
T4024 1649-1652 Positive_regulation denotes for
T4025 1649-1652 Positive_regulation denotes for
T4026 1649-1652 Positive_regulation denotes for
T4027 1649-1652 Positive_regulation denotes for
T4028 1649-1652 Positive_regulation denotes for
T4029 1649-1652 Positive_regulation denotes for
T4030 1649-1652 Positive_regulation denotes for
T4031 1649-1652 Positive_regulation denotes for
T4032 1649-1652 Positive_regulation denotes for
T4033 1649-1652 Positive_regulation denotes for
T4034 1649-1652 Positive_regulation denotes for
T4035 1649-1652 Positive_regulation denotes for
T4036 1649-1652 Positive_regulation denotes for
T4037 1649-1652 Positive_regulation denotes for
T4038 1649-1652 Positive_regulation denotes for
T4039 1649-1652 Positive_regulation denotes for
T4040 1649-1652 Positive_regulation denotes for
T4041 1649-1652 Positive_regulation denotes for
T4042 1649-1652 Positive_regulation denotes for
T4043 1649-1652 Positive_regulation denotes for
T4044 1649-1652 Positive_regulation denotes for
T4045 1649-1652 Positive_regulation denotes for
T4046 1649-1652 Positive_regulation denotes for
T4047 1649-1652 Positive_regulation denotes for
T4048 1649-1652 Positive_regulation denotes for
T4049 1649-1652 Positive_regulation denotes for
T4050 1649-1652 Positive_regulation denotes for
T4051 1649-1652 Positive_regulation denotes for
T4052 1649-1652 Positive_regulation denotes for
T4053 1649-1652 Positive_regulation denotes for
T4054 1649-1652 Positive_regulation denotes for
T4055 1669-1681 Binding denotes dimerization
T4056 1669-1681 Binding denotes dimerization
T4057 1669-1681 Binding denotes dimerization
T4058 1669-1681 Binding denotes dimerization
T4059 1669-1681 Binding denotes dimerization
T4060 1690-1697 Binding denotes binding
T4061 1690-1697 Binding denotes binding
T4062 1690-1697 Binding denotes binding
T4063 1690-1697 Binding denotes binding
T4064 1690-1697 Binding denotes binding
T4065 1867-1870 Protein denotes p65
T4066 1872-1876 Protein denotes RelB
T4067 1881-1886 Protein denotes c-Rel
T4068 2249-2254 Protein denotes IκB-α
T4069 2301-2315 Phosphorylation denotes phosphorylated
T4070 2301-2315 Phosphorylation denotes phosphorylated
T4071 2326-2331 Entity denotes Ser32
T4072 2336-2341 Entity denotes Ser36
T4073 2364-2377 Ubiquitination denotes ubiquitylated
T4074 2364-2377 Ubiquitination denotes ubiquitylated
T4075 2381-2386 Entity denotes Lys21
T4076 2391-2396 Entity denotes Lys22
T4077 2403-2411 Protein_catabolism denotes degraded
T4078 2412-2414 Positive_regulation denotes by
T4079 2473-2488 Phosphorylation denotes phosphorylation
T4080 2473-2488 Phosphorylation denotes phosphorylation
T4081 2473-2488 Phosphorylation denotes phosphorylation
T4082 2492-2495 Protein denotes p65
T4083 2499-2505 Entity denotes Ser276
T4084 2506-2508 Positive_regulation denotes by
T4085 2517-2521 Protein denotes MSK1
T4086 2529-2535 Entity denotes Ser311
T4087 2536-2538 Positive_regulation denotes by
T4088 2539-2543 Protein denotes PKCζ
T4089 2552-2558 Entity denotes Ser536
T4090 2559-2561 Positive_regulation denotes by
T4091 2562-2566 Protein denotes IKKα
T4092 2576-2587 Acetylation denotes Acetylation
T4093 2576-2587 Acetylation denotes Acetylation
T4094 2591-2594 Protein denotes p65
T4095 2598-2604 Entity denotes Lys218
T4096 2609-2615 Entity denotes Lys221
T4097 2616-2625 Positive_regulation denotes increases
T4098 2616-2625 Positive_regulation denotes increases
T4099 2634-2641 Binding denotes binding
T4100 2646-2653 Negative_regulation denotes impairs
T4101 2646-2653 Negative_regulation denotes impairs
T4102 2658-2669 Binding denotes association
T4103 2675-2680 Protein denotes IκB-α
T4104 2686-2697 Acetylation denotes acetylation
T4105 2701-2707 Entity denotes Lys310
T4106 2721-2724 Protein denotes p65
T4107 2903-2908 Protein denotes IκB-α
T4108 2939-2942 Protein denotes A20
T4109 2952-2965 Deacetylation denotes Deacetylation
T4110 2952-2965 Deacetylation denotes Deacetylation
T4111 2969-2972 Protein denotes p65
T4112 2976-2997 Protein denotes histone deacetylase-3
T4113 3001-3006 Protein denotes SIRT1
T4114 3011-3022 Deacetylation denotes acetylation
T4115 3011-3022 Deacetylation denotes acetylation
T4116 3026-3029 Protein denotes p65
T4117 3033-3039 Entity denotes Lys122
T4118 3044-3050 Entity denotes Lys123
T4119 3810-3817 Binding denotes binding
T4120 3825-3830 Protein denotes gp120
T4121 3849-3852 Protein denotes CD4
T4122 3853-3860 Positive_regulation denotes induces
T4123 3883-3893 Positive_regulation denotes activation
T4124 3910-3922 Protein denotes procaspase 8
T4125 3982-3985 Protein denotes Tat
T4126 3994-4003 Binding denotes interacts
T4127 4079-4082 Protein denotes Tat
T4128 4083-4088 Binding denotes binds
T4129 4231-4254 Protein denotes tumor necrosis factor β
T4130 4256-4260 Protein denotes TNFβ
T4131 4271-4284 Protein denotes interleukin-6
T4132 4286-4290 Protein denotes IL-6
T4133 4300-4308 Positive_regulation denotes activate
T4134 4300-4308 Positive_regulation denotes activate
T4135 4314-4327 Transcription denotes transcription
T4136 4314-4327 Transcription denotes transcription
T4137 4337-4340 Protein denotes Tat
T4138 4399-4410 Binding denotes interacting
T4139 4399-4410 Binding denotes interacting
T4140 4399-4410 Binding denotes interacting
T4141 4399-4410 Binding denotes interacting
T4142 4399-4410 Binding denotes interacting
T4143 4399-4410 Binding denotes interacting
T4144 4399-4410 Binding denotes interacting
T4145 4399-4410 Binding denotes interacting
T4146 4399-4410 Binding denotes interacting
T4147 4459-4462 Protein denotes Sp1
T4148 4469-4474 Protein denotes TFIID
T4149 4481-4486 Protein denotes E2F-4
T4150 4493-4499 Protein denotes C/EBPβ
T4151 4506-4515 Protein denotes cyclin T1
T4152 4516-4520 Protein denotes CDK9
T4153 4564-4568 Protein denotes p300
T4154 4569-4572 Protein denotes CBP
T4155 4577-4582 Protein denotes P/CAF
T4156 4597-4605 Localization denotes released
T4157 4633-4636 Protein denotes Tat
T4158 4671-4678 Binding denotes binding
T4159 4722-4739 Protein denotes Flk1/KDR receptor
T4160 4858-4867 Gene_expression denotes expressed
T4161 4872-4875 Protein denotes Tat
T4162 4940-4943 Protein denotes Tat
T4163 4944-4951 Positive_regulation denotes induced
T4164 4985-4996 Protein_catabolism denotes degradation
T4165 5000-5005 Protein denotes IκB-α
T4166 5030-5033 Protein denotes p65
T4167 5062-5072 Negative_regulation denotes inhibiting
T4168 5077-5083 Protein denotes SIRT-1
T4169 5084-5092 Positive_regulation denotes mediated
T4170 5093-5106 Deacetylation denotes deacetylation
T4171 5110-5113 Protein denotes p65
T4172 5114-5120 Entity denotes Lys310
T4173 5157-5160 Protein denotes Tat
T4174 5244-5247 Protein denotes Tat
T4175 5331-5340 Gene_expression denotes synthesis
T4176 5344-5349 Protein denotes IκB-α
T4177 5384-5389 Protein denotes IκB-α
T4178 5390-5395 Binding denotes binds
T4179 5399-5402 Protein denotes Tat
T4180 5502-5505 Protein denotes Tat
T4181 5571-5582 Binding denotes interaction
T4182 5588-5593 Protein denotes IκB-α
T4183 5598-5601 Protein denotes p65
T4840 5876-5886 Protein denotes 3xHA-IκB-α
T4841 5900-5903 Protein denotes Tat
T4842 5917-5933 Protein denotes Tat C(22,25,27)A
T4843 5947-5972 Protein denotes Tat R(49,52,53,55,56,57)A
T4844 5982-5985 Protein denotes Tat
T4845 5995-6011 Protein denotes Tat C(22,25,27)A
T4846 6024-6049 Protein denotes Tat R(49,52,53,55,56,57)A
T4847 6121-6124 Protein denotes env
T4848 6241-6246 Protein denotes β-Gal
T4849 6316-6324 Protein denotes 3xHA-p65
T4850 6334-6344 Protein denotes 3xHA-p65ΔC
T4851 6361-6371 Protein denotes 3xHA-p65ΔN
T4852 6394-6409 Protein denotes Tat T,N(23,24)A
T4853 6423-6436 Protein denotes Tat K(50,51)A
T4854 6446-6461 Protein denotes Tat T,N(23,24)A
T4855 6471-6484 Protein denotes Tat K(50,51)A
T4856 6501-6504 Protein denotes Tat
T5622 6598-6608 Protein denotes luciferase
T5623 6621-6624 Protein denotes p50
T5624 6627-6630 Protein denotes p65
T5625 7015-7018 Protein denotes p50
T5626 7021-7024 Protein denotes p65
T5627 7428-7451 Protein denotes tumor necrosis factor-α
T5628 7453-7458 Protein denotes TNF-α
T5629 7572-7582 Protein denotes luciferase
T5630 7595-7600 Protein denotes β-Gal
T5631 7755-7765 Protein denotes Luciferase
T5632 7808-7818 Protein denotes luciferase
T5633 7823-7838 Protein denotes β-galactosidase
T8128 13252-13261 Protein denotes protein G
T8129 13594-13603 Protein denotes protein G
T8130 14484-14490 Protein denotes MIP-1α
T8131 14492-14497 Protein denotes GAPDH
T8132 14502-14506 Protein denotes ACTB
T8133 14558-14562 Protein denotes CSF3
T8134 14564-14567 Protein denotes LTA
T8135 14569-14575 Protein denotes NFKBIA
T8136 14580-14584 Protein denotes TLR2
T11057 14991-14994 Protein denotes Tat
T11058 15026-15035 Binding denotes hijacking
T11059 15036-15041 Protein denotes IκB-α
T11060 15174-15184 Regulation denotes modulating
T11061 15189-15199 Gene_expression denotes expression
T11062 15203-15206 Protein denotes Tat
T11063 15265-15274 Protein denotes siRNA Tat
T11073 15820-15827 Positive_regulation denotes induced
T11074 15943-15952 Protein denotes siRNA Tat
T11075 15992-15995 Protein denotes Tat
T11076 17304-17307 Protein denotes p65
T11077 17308-17311 Protein denotes p50
T11078 17312-17319 Binding denotes binding true
T11079 17312-17319 Binding denotes binding true
T11080 17382-17385 Protein denotes p65
T11081 17457-17460 Protein denotes Tat
T11082 17502-17505 Protein denotes Tat
T11083 17516-17525 Protein denotes siRNA Tat
T11084 17571-17574 Protein denotes p65
T11085 17579-17586 Binding denotes binding
T11086 17599-17602 Protein denotes p65
T11087 17613-17621 Positive_regulation denotes elevated
T11088 17613-17621 Positive_regulation denotes elevated
T11089 17637-17640 Protein denotes Tat
T11090 17682-17689 Negative_regulation denotes dropped
T11091 17682-17689 Negative_regulation denotes dropped
T11092 17693-17700 Negative_regulation denotes absence
T11093 17704-17707 Protein denotes Tat
T11094 17709-17718 Protein denotes siRNA Tat
T11095 17739-17744 Protein denotes IκB-α
T11096 17749-17757 Protein_catabolism denotes degraded
T11097 17811-17822 Gene_expression denotes synthesized
T11098 17885-17888 Protein denotes Tat
T11099 17902-17905 Protein denotes Tat
T11100 18078-18081 Protein denotes Tat
T11101 18150-18155 Protein denotes IκB-α
T11102 18156-18167 Protein_catabolism denotes degradation
T11103 18168-18180 Gene_expression denotes re-synthesis
T11104 18186-18194 Positive_regulation denotes observed
T11105 18186-18194 Positive_regulation denotes observed
T11106 18492-18497 Protein denotes IκB-α
T11107 18498-18509 Protein_catabolism denotes degradation
T11108 18543-18546 Protein denotes Tat
T11109 18588-18591 Protein denotes Tat
T11110 18640-18649 Gene_expression denotes synthesis
T11111 18653-18658 Protein denotes IκB-α
T11112 18697-18700 Protein denotes Tat
T11113 18805-18808 Protein denotes Tat
T11114 18971-18974 Protein denotes p65
T11115 18979-18986 Binding denotes binding
T11116 19011-19014 Protein denotes p65
T11117 19050-19058 Positive_regulation denotes enhanced
T11118 19050-19058 Positive_regulation denotes enhanced
T11119 19062-19065 Protein denotes Tat
T11120 19077-19082 Protein denotes IκB-α
T11121 19113-19121 Regulation denotes affected true
T11122 19175-19184 Positive_regulation denotes increased
T11123 19228-19231 Protein denotes p65
T11124 19263-19276 Regulation denotes independently true
T11125 19296-19299 Protein denotes Tat
T11126 19338-19341 Protein denotes p65
T11127 19346-19353 Binding denotes binding
T11128 19366-19369 Protein denotes p65
T11129 19380-19388 Positive_regulation denotes elevated
T11130 19380-19388 Positive_regulation denotes elevated
T11131 19418-19421 Protein denotes Tat
T11132 19443-19450 Negative_regulation denotes dropped
T11133 19443-19450 Negative_regulation denotes dropped
T11134 19454-19457 Protein denotes Tat
T11135 19458-19466 Negative_regulation denotes negative
T11136 19505-19508 Protein denotes Tat
T11137 19509-19514 Binding denotes bound
T11138 19575-19582 Binding denotes binding
T11139 19583-19592 Positive_regulation denotes increased
T11140 19717-19728 Protein_catabolism denotes Degradation
T11141 19732-19737 Protein denotes IκB-α
T11142 19756-19763 Positive_regulation denotes induced
T11143 19777-19785 Positive_regulation denotes followed
T11144 19797-19806 Gene_expression denotes synthesis
T11145 19860-19863 Protein denotes Tat
T11146 20023-20026 Protein denotes Tat
T11147 20069-20072 Protein denotes Tat
T11148 20151-20160 Regulation denotes affecting true
T11149 20182-20187 Protein denotes IκB-α
T11150 21841-21844 Protein denotes Tat
T11151 21845-21850 Binding denotes binds
T11152 21858-21871 Entity denotes sixth ankyrin
T11153 21875-21880 Protein denotes IκB-α
T11154 21908-21911 Protein denotes Tat
T11155 21912-21924 Negative_regulation denotes counteracted true
T11156 21929-21939 Binding denotes generation
T11157 21947-21952 Protein denotes IκB-α
T11158 21985-21996 Binding denotes association true
T11159 22000-22005 Protein denotes IκB-α
T11160 22011-22014 Protein denotes p65
T11161 22162-22171 Gene_expression denotes synthesis
T11162 22175-22180 Protein denotes IκB-α
T11163 22196-22217 Binding denotes Coimmunoprecipitation
T11164 22221-22226 Protein denotes IκB-α
T11165 22232-22235 Protein denotes p65
T11166 22285-22288 Protein denotes Tat
T11167 22340-22346 Negative_regulation denotes halved
T11168 22350-22353 Protein denotes Tat
T11169 22376-22379 Protein denotes Tat
T11170 22380-22400 Binding denotes coimmunoprecipitated
T11171 22406-22411 Protein denotes IκB-α
T11172 22456-22459 Protein denotes Tat
T11173 22460-22468 Negative_regulation denotes competed
T11174 22473-22478 Protein denotes IκB-α
T11175 22479-22486 Binding denotes binding
T11176 22490-22493 Protein denotes p65
T12909 22496-22499 Protein denotes Tat
T12910 22500-22511 Negative_regulation denotes counteracts
T12911 22516-22521 Protein denotes IκB-α
T12912 22522-22532 Negative_regulation denotes inhibition
T12913 22536-22539 Protein denotes p65
T12914 22543-22552 Negative_regulation denotes competing
T12915 22567-22574 Binding denotes binding
T12916 22612-22623 Binding denotes interaction
T12917 22627-22630 Protein denotes Tat
T12918 22636-22641 Protein denotes IκB-α
T12919 22769-22772 Protein denotes Tat
T12920 22782-22797 Protein denotes Tat T,N(23,24)A
T12921 22799-22815 Protein denotes Tat C(22,25,27)A
T12922 22817-22830 Protein denotes Tat K(50,51)A
T12923 22835-22848 Protein denotes Tat R(49–57)A
T12924 22862-22867 Protein denotes IκB-α
T12925 22868-22888 Binding denotes coimmunoprecipitated true
T12926 22868-22888 Binding denotes coimmunoprecipitated true
T12927 22898-22901 Protein denotes Tat
T12928 22919-22932 Protein denotes Tat R(49–57)A
T12929 22979-22999 Entity denotes arginine-rich domain
T12930 23003-23006 Protein denotes Tat
T12931 23011-23019 Positive_regulation denotes involved
T12932 23027-23034 Binding denotes binding
T12933 23038-23043 Protein denotes IκB-α
T12934 23112-23115 Protein denotes Tat
T12935 23116-23127 Binding denotes associating
T12936 23133-23138 Protein denotes IκB-α
T12937 23139-23147 Negative_regulation denotes competed
T12938 23152-23159 Binding denotes binding
T12939 23163-23168 Protein denotes IκB-α
T12940 23172-23175 Protein denotes p65
T12941 23233-23246 Protein denotes Tat R(49–57)A
T12942 23254-23260 Negative_regulation denotes lacked
T12943 23265-23272 Binding denotes binding
T12944 23273-23277 Entity denotes site
T12945 23282-23287 Protein denotes IκB-α
T12946 23297-23306 Binding denotes associate true
T12947 23312-23317 Protein denotes IκB-α
T12948 23330-23337 Negative_regulation denotes compete true
T12949 23342-23349 Binding denotes binding
T12950 23353-23358 Protein denotes IκB-α
T12951 23362-23365 Protein denotes p65
T12952 25511-25514 Protein denotes Tat
T12953 25515-25527 Negative_regulation denotes counteracted true
T12954 25532-25537 Protein denotes IκB-α
T12955 25547-25557 Negative_regulation denotes inhibition
T12956 25561-25564 Protein denotes p65
T12957 25565-25572 Binding denotes binding
T12958 25614-25617 Protein denotes p65
T12959 25622-25627 Protein denotes IκB-α
T12960 25684-25687 Protein denotes Tat
T12961 25710-25713 Protein denotes p65
T12962 25718-25725 Binding denotes binding
T12963 25739-25748 Negative_regulation denotes inhibited
T12964 25752-25757 Protein denotes IκB-α
T12965 25762-25770 Negative_regulation denotes restored true
T12966 25762-25770 Negative_regulation denotes restored true
T12967 25811-25814 Protein denotes Tat
T12968 25827-25839 Protein denotes Tat R(49–57)
T12969 25878-25881 Protein denotes Tat
T12970 25896-25901 Protein denotes IκB-α
T12971 25916-25919 Protein denotes p65
T12972 25961-25964 Protein denotes p50
T12973 25967-25970 Protein denotes p65
T12974 25993-25996 Protein denotes Luc
T12975 26042-26045 Protein denotes p65
T12976 26050-26055 Protein denotes IκB-α
T12977 26083-26086 Protein denotes Tat
T12978 26088-26093 Protein denotes IκB-α
T12979 26094-26103 Negative_regulation denotes inhibited
T12980 26108-26111 Protein denotes p65
T12981 26112-26121 Positive_regulation denotes dependent
T12982 26122-26132 Gene_expression denotes expression
T12983 26140-26150 Protein denotes luciferase
T12984 26167-26175 Negative_regulation denotes restored true
T12985 26167-26175 Negative_regulation denotes restored true
T12986 26216-26219 Protein denotes Tat
T12987 26232-26245 Protein denotes Tat R(49–57)A
T12988 26299-26302 Protein denotes Tat
T12989 26303-26314 Negative_regulation denotes counteracts
T12990 26303-26314 Negative_regulation denotes counteracts
T12991 26319-26324 Protein denotes IκB-α
T12992 26325-26335 Negative_regulation denotes repression
T12993 26343-26346 Protein denotes p65
T12994 26351-26358 Binding denotes binding
T12995 26391-26402 Binding denotes associating
T12996 26408-26413 Protein denotes IκB-α
T12997 26418-26427 Negative_regulation denotes competing
T12998 26442-26449 Binding denotes binding
T12999 26453-26456 Protein denotes p65
T14678 26459-26462 Protein denotes Tat
T14679 26463-26472 Positive_regulation denotes increases
T14680 26477-26480 Protein denotes p65
T14681 26490-26497 Binding denotes binding
T14682 26513-26524 Binding denotes association
T14683 26530-26533 Protein denotes p65
T14684 26552-26555 Protein denotes Tat
T14685 26567-26577 Binding denotes interacted true
T14686 26583-26586 Protein denotes p65
T14687 26647-26653 Protein denotes HA-p65
T14688 26658-26666 Protein denotes FLAG-Tat
T14689 26683-26686 Protein denotes Tat
T14690 26691-26709 Gene_expression denotes immunoprecipitated
T14691 26734-26737 Protein denotes p65
T14692 26750-26770 Binding denotes coimmunoprecipitated
T14693 26786-26789 Protein denotes Tat
T14694 26805-26820 Protein denotes Tat T,N(23,24)A
T14695 26822-26835 Protein denotes Tat K(50,51)A
T14696 26840-26853 Protein denotes Tat R(49–57)A
T14697 26893-26901 Negative_regulation denotes decrease
T14698 26905-26926 Binding denotes coimmunoprecipitation
T14699 26944-26960 Protein denotes Tat C(22,25,27)A
T14700 26988-26991 Protein denotes GST
T14701 27052-27059 Binding denotes binding
T14702 27063-27066 Protein denotes p65
T14703 27080-27083 Protein denotes Tat
T14704 27100-27115 Protein denotes Tat T,N(23,24)A
T14705 27117-27130 Protein denotes Tat K(50,51)A
T14706 27135-27148 Protein denotes Tat R(49–57)A
T14707 27162-27169 Binding denotes binding true
T14708 27173-27189 Protein denotes Tat C(22,25,27)A
T14709 27232-27235 Protein denotes Tat
T14710 27236-27246 Binding denotes associated
T14711 27252-27255 Protein denotes p65
T14712 27268-27288 Entity denotes cysteine-rich domain
T14713 27343-27350 Positive_regulation denotes mediate true
T14714 29109-29112 Protein denotes p65
T14715 29113-29119 Entity denotes domain
T14716 29120-29128 Positive_regulation denotes required true
T14717 29133-29140 Binding denotes binding
T14718 29144-29147 Protein denotes Tat
T14719 29182-29190 Protein denotes FLAG-Tat
T14720 29205-29211 Protein denotes HA-p65
T14721 29232-29239 Negative_regulation denotes deleted
T14722 29232-29239 Negative_regulation denotes deleted
T14723 29247-29269 Entity denotes transactivation domain
T14724 29271-29284 Protein denotes p65ΔC (1–318)
T14725 29294-29297 Entity denotes RHD
T14726 29299-29314 Protein denotes p65ΔN (122–551)
T14727 29329-29332 Protein denotes Tat
T14728 29333-29353 Binding denotes coimmunoprecipitated true
T14729 29359-29372 Protein denotes p65ΔC (1–318)
T14730 29387-29402 Protein denotes p65ΔN (122–551)
T14731 29436-29439 Entity denotes RHD
T14732 29443-29446 Protein denotes p65
T14733 29476-29487 Binding denotes interaction
T14734 29493-29496 Protein denotes Tat
T14735 29513-29519 Regulation denotes effect true
T14736 29523-29526 Protein denotes Tat
T14737 29534-29537 Protein denotes p65
T14738 29542-29549 Binding denotes binding
T14739 29581-29584 Protein denotes p65
T14740 29698-29701 Protein denotes Tat
T14741 29705-29721 Protein denotes Tat C(22,25,27)A
T14742 29727-29730 Protein denotes p65
T14743 29735-29742 Binding denotes binding true
T14744 29783-29786 Protein denotes Tat
T14745 29801-29810 Positive_regulation denotes increased
T14746 29815-29822 Binding denotes binding
T14747 29826-29829 Protein denotes p65
T14748 29849-29865 Protein denotes Tat C(22,25,27)A
T14749 29867-29874 Negative_regulation denotes lacking
T14750 29879-29886 Binding denotes binding
T14751 29887-29891 Entity denotes site
T14752 29896-29899 Protein denotes p65
T14753 29905-29916 Positive_regulation denotes ineffective true
T14754 29934-29937 Protein denotes p65
T14755 29938-29945 Binding denotes binding true
T14756 30066-30069 Protein denotes Tat
T14757 30084-30092 Positive_regulation denotes enhanced
T14758 30097-30100 Protein denotes p65
T14759 30110-30117 Binding denotes binding
T17262 30145-30148 Protein denotes Tat
T17263 30163-30166 Protein denotes p65
T17264 30215-30223 Binding denotes occupies
T17265 30248-30256 Positive_regulation denotes promotes
T17266 30248-30256 Positive_regulation denotes promotes
T17267 30261-30264 Protein denotes p65
T17268 30265-30276 Binding denotes recruitment
T17269 30282-30287 Protein denotes IκB-α
T17270 30288-30300 Binding denotes displacement true
T17271 30327-30330 Protein denotes Tat
T17272 30430-30438 Protein denotes FLAG-Tat
T17273 30440-30461 Protein denotes FLAG-Tat C(22,25,27)A
T17274 30465-30483 Protein denotes FLAG-Tat R(49–57)A
T17275 30583-30586 Protein denotes Tat
T17276 30601-30610 Positive_regulation denotes increased
T17277 30601-30610 Positive_regulation denotes increased
T17278 30601-30610 Positive_regulation denotes increased
T17279 30601-30610 Positive_regulation denotes increased
T17280 30601-30610 Positive_regulation denotes increased
T17281 30615-30625 Gene_expression denotes expression
T17282 30615-30625 Gene_expression denotes expression
T17283 30615-30625 Gene_expression denotes expression
T17284 30615-30625 Gene_expression denotes expression
T17285 30615-30625 Gene_expression denotes expression
T17287 30637-30641 Protein denotes CSF3
T17288 30643-30646 Protein denotes LTA
T17289 30648-30654 Protein denotes NFKBIA
T17290 30659-30663 Protein denotes TLR2
T17291 30683-30699 Protein denotes Tat C(22,25,27)A
T17292 30704-30717 Protein denotes Tat R(49–57)A
T17293 30723-30734 Positive_regulation denotes ineffective true
T17294 30723-30734 Positive_regulation denotes ineffective true
T17295 30723-30734 Positive_regulation denotes ineffective true
T17296 30723-30734 Positive_regulation denotes ineffective true
T17297 30723-30734 Positive_regulation denotes ineffective true
T17298 30723-30734 Positive_regulation denotes ineffective true
T17299 30723-30734 Positive_regulation denotes ineffective true
T17300 30723-30734 Positive_regulation denotes ineffective true
T17301 30723-30734 Positive_regulation denotes ineffective true
T17302 30723-30734 Positive_regulation denotes ineffective true
T17303 30754-30757 Protein denotes Tat
T17304 30860-30869 Protein denotes siRNA p65
T17305 30891-30894 Protein denotes Tat
T17306 30938-30941 Protein denotes p65
T17307 31016-31021 Protein denotes GAPDH
T17308 31026-31030 Protein denotes ACTB
T17309 31063-31066 Protein denotes Tat
T17310 31200-31203 Protein denotes Tat
T17311 31298-31301 Protein denotes Tat
T17312 31331-31342 Binding denotes interaction
T17313 31369-31372 Protein denotes p65
T17314 31377-31382 Protein denotes IκB-α
T17315 32978-32984 Protein denotes MIP-1α
T17316 33007-33016 Positive_regulation denotes activated
T17317 33025-33028 Protein denotes Tat
T17318 33148-33154 Protein denotes MIP-1α
T17319 33155-33165 Gene_expression denotes expression
T17320 33170-33179 Positive_regulation denotes increased
T17321 33247-33253 Protein denotes MIP-1α
T17322 33254-33264 Gene_expression denotes production
T17323 33269-33276 Positive_regulation denotes induced
T17324 33308-33311 Protein denotes Tat
T17325 33336-33351 Transcription denotes transcriptional
T17326 33352-33362 Regulation denotes regulation
T17327 33366-33372 Protein denotes MIP-1α
T17328 33535-33541 Protein denotes MIP-1α
T17329 33723-33729 Protein denotes MIP-1α
T17330 33770-33775 Protein denotes TNF-α
T17331 33822-33832 Gene_expression denotes expression true
T17332 33843-33849 Protein denotes MIP-1α
T17333 33876-33879 Protein denotes p65
T17334 33880-33889 Binding denotes occupancy true
T17335 33897-33908 Entity denotes NF-κB sites
T17336 33918-33923 Protein denotes TNF-α
T17337 33924-33933 Positive_regulation denotes activated
T17338 33938-33948 Gene_expression denotes expression
T17339 33952-33958 Protein denotes MIP-1α
T17340 33963-33970 Positive_regulation denotes induced
T17341 33975-33978 Protein denotes p65
T17342 33979-33990 Binding denotes recruitment
T17343 33998-34009 Entity denotes NF-κB1 site
T17344 34013-34019 Protein denotes MIP-1α
T17345 34028-34037 Positive_regulation denotes affecting true
T17346 34042-34051 Binding denotes occupancy
T17347 34128-34131 Protein denotes Tat
T17348 34137-34145 Positive_regulation denotes promoted
T17349 34150-34161 Binding denotes recruitment
T17350 34165-34168 Protein denotes p65
T17351 34176-34187 Entity denotes NF-κB1 site
T17352 34191-34197 Protein denotes MIP-1α
T17353 34389-34395 Protein denotes MIP-1α
T17354 34420-34425 Protein denotes TNF-α
T17355 34430-34433 Protein denotes Tat
T17356 34448-34454 Protein denotes MIP-1α
T17357 34456-34459 Protein denotes Tat
T17358 34460-34469 Positive_regulation denotes increased
T17359 34460-34469 Positive_regulation denotes increased
T17360 34460-34469 Positive_regulation denotes increased
T17361 34460-34469 Positive_regulation denotes increased
T17362 34474-34485 Binding denotes recruitment
T17363 34474-34485 Binding denotes recruitment
T17364 34474-34485 Binding denotes recruitment
T17365 34474-34485 Binding denotes recruitment
T17366 34489-34492 Protein denotes p65
T17367 34500-34515 Entity denotes NF-κB enhancers
T17368 34519-34523 Protein denotes CSF3
T17369 34525-34528 Protein denotes LTA
T17370 34530-34536 Protein denotes NFKBIA
T17371 34541-34545 Protein denotes TLR2
T17372 34560-34571 Positive_regulation denotes ineffective true
T17373 34560-34571 Positive_regulation denotes ineffective true
T17374 34579-34588 Entity denotes promoters
T17375 34592-34597 Protein denotes GAPDH
T17376 34602-34606 Protein denotes ACTB
T17377 34629-34632 Protein denotes Tat
T17378 34633-34638 Binding denotes bound true
T17379 34689-34694 Protein denotes GAPDH
T17380 34699-34703 Protein denotes ACTB
T17381 34704-34713 Entity denotes promoters
T17382 34720-34724 Negative_regulation denotes loss
T17383 34746-34749 Protein denotes p65
T17384 34754-34766 Negative_regulation denotes interference
T17385 34796-34799 Protein denotes Tat
T17386 34800-34809 Binding denotes occupancy
T17387 34819-34822 Positive_regulation denotes via true
T17388 34823-34826 Protein denotes p65
T17389 34827-34838 Binding denotes interaction true
T17390 34864-34869 Protein denotes IκB-α
T17391 34874-34902 Binding denotes chromatin-immunoprecipitated
T17392 34940-34943 Protein denotes Tat
T17393 34970-34977 Negative_regulation denotes removed
T17394 34970-34977 Negative_regulation denotes removed
T17395 34993-34996 Protein denotes Tat
T17396 35011-35016 Protein denotes IκB-α
T17397 35021-35033 Negative_regulation denotes interference
T17398 35063-35066 Protein denotes Tat
T17399 35067-35076 Negative_regulation denotes displaced
T17400 35077-35082 Protein denotes IκB-α
T17401 35083-35087 Binding denotes from
T19087 35128-35131 Protein denotes Tat
T19088 35164-35172 Positive_regulation denotes promotes
T19089 35177-35192 Transcription denotes transcriptional
T19090 35193-35203 Positive_regulation denotes activation
T19091 35207-35213 Protein denotes MIP-1α
T19092 35214-35216 Positive_regulation denotes by
T19093 35217-35228 Binding denotes interacting
T19094 35234-35239 Protein denotes IκB-α
T19095 35244-35247 Protein denotes p65
T19096 35273-35276 Protein denotes Tat
T19097 35277-35285 Regulation denotes affected true
T19098 35313-35323 Gene_expression denotes expression
T19099 35327-35333 Protein denotes MIP-1α
T19100 35382-35385 Protein denotes Tat
T19101 35412-35415 Protein denotes Env
T19102 35434-35442 Protein denotes FLAG-Tat
T19103 35565-35574 Protein denotes siRNA Tat
T19104 35615-35623 Regulation denotes modulate
T19105 35628-35631 Protein denotes Tat
T19106 35632-35642 Gene_expression denotes expression
T19107 35729-35739 Gene_expression denotes expression
T19108 35729-35739 Gene_expression denotes expression
T19109 35743-35746 Protein denotes Tat
T19110 35751-35754 Protein denotes p24
T19111 35818-35826 Negative_regulation denotes detected
T19112 35818-35826 Negative_regulation denotes detected
T19113 35830-35839 Protein denotes siRNA Tat
T19114 38161-38164 Protein denotes p65
T19115 38169-38176 Binding denotes binding
T19116 38182-38189 Positive_regulation denotes induced
T19117 38220-38223 Protein denotes Tat
T19118 38266-38269 Protein denotes Tat
T19119 38286-38295 Protein denotes siRNA Tat
T19120 38302-38311 Positive_regulation denotes increased
T19121 38328-38331 Protein denotes Tat
T19122 38360-38371 Protein_catabolism denotes Degradation
T19123 38375-38380 Protein denotes IκB-α
T19124 38425-38433 Positive_regulation denotes followed
T19125 38445-38454 Gene_expression denotes synthesis
T19126 38458-38463 Protein denotes IκB-α
T19127 38472-38485 Regulation denotes independently true
T19128 38493-38496 Protein denotes Tat
T19129 38628-38631 Protein denotes Tat
T19130 38928-38931 Protein denotes Tat
T19131 38936-38956 Binding denotes coimmunoprecipitated
T19132 38962-38967 Protein denotes IκB-α
T19133 38972-38975 Protein denotes p65
T19134 38993-39002 Positive_regulation denotes activated
T19135 39007-39013 Protein denotes MIP-1α
T19136 39014-39024 Gene_expression denotes expression
T19137 39030-39033 Protein denotes p65
T19138 39034-39043 Positive_regulation denotes dependent
T19139 39068-39072 Negative_regulation denotes lack
T19140 39083-39092 Positive_regulation denotes following
T19141 39113-39116 Protein denotes Tat
T19142 39120-39123 Protein denotes p65
T19143 39147-39150 Protein denotes Tat
T19144 39155-39158 Protein denotes p65
T19145 39169-39178 Binding denotes recruited
T19146 39186-39200 Entity denotes NF-κB enhancer
T19147 39204-39210 Protein denotes MIP-1α
T19148 39222-39225 Protein denotes p65
T19149 39226-39235 Binding denotes occupancy
T19150 39240-39249 Negative_regulation denotes abolished
T19151 39253-39262 Protein denotes siRNA Tat
T19152 39354-39357 Protein denotes Tat
T19153 39358-39368 Binding denotes associated
T19154 39374-39379 Protein denotes IκB-α
T19155 39384-39387 Protein denotes p65
T19156 39393-39400 Positive_regulation denotes induced
T19157 39405-39408 Protein denotes p65
T19158 39419-39429 Positive_regulation denotes activation
T19159 39433-39439 Protein denotes MIP-1α
T19160 39440-39450 Gene_expression denotes expression
T19161 39459-39468 Binding denotes occupancy
T19162 39476-39482 Protein denotes MIP-1α
T19163 39483-39491 Entity denotes promoter
T19164 39496-39505 Positive_regulation denotes increased
T19165 39506-39517 Binding denotes recruitment
T19166 39521-39524 Protein denotes p65
T23389 39608-39611 Protein denotes Tat
T23390 39655-39658 Protein denotes Tat
T23391 39704-39707 Protein denotes p65
T23392 39752-39762 Binding denotes interacted
T23393 39772-39777 Protein denotes IκB-α
T23394 39834-39837 Protein denotes Tat
T23395 39870-39881 Binding denotes interaction true
T23396 39887-39892 Protein denotes IκB-α
T23397 39897-39900 Protein denotes p65
T23398 40006-40013 Negative_regulation denotes silence true
T23399 40018-40021 Protein denotes Tat
T23400 40022-40032 Gene_expression denotes expression
T23401 40283-40288 Protein denotes IκB-α
T23402 40289-40300 Protein_catabolism denotes degradation
T23403 40308-40315 Negative_regulation denotes absence
T23404 40319-40322 Protein denotes Tat
T23405 40372-40381 Gene_expression denotes synthesis
T23406 40385-40390 Protein denotes IκB-α
T23407 40448-40451 Protein denotes Tat
T23408 40486-40495 Negative_regulation denotes silencing
T23409 40503-40506 Protein denotes Tat
T23410 40575-40578 Protein denotes Tat
T23411 40615-40624 Regulation denotes affecting true
T23412 40663-40668 Protein denotes IκB-α
T23413 40742-40745 Protein denotes Tat
T23414 40776-40779 Protein denotes Tat
T23415 40849-40860 Gene_expression denotes synthesized
T23416 40861-40866 Protein denotes IκB-α
T23417 40872-40875 Protein denotes Tat
T23418 40926-40937 Binding denotes association
T23419 40964-40969 Protein denotes IκB-α
T23420 40977-40987 Negative_regulation denotes interfered
T23421 40997-41007 Binding denotes generation
T23422 41015-41020 Protein denotes IκB-α
T23423 41021-41024 Protein denotes p65
T23424 41066-41069 Protein denotes Tat
T23425 41070-41078 Negative_regulation denotes competed
T23426 41087-41094 Binding denotes binding
T23427 41098-41103 Protein denotes IκB-α
T23428 41107-41110 Protein denotes p65
T23429 41115-41124 Negative_regulation denotes prevented
T23430 41129-41134 Protein denotes IκB-α
T23431 41135-41145 Negative_regulation denotes repression
T23432 41149-41152 Protein denotes p65
T23433 41199-41202 Protein denotes Tat
T23434 41203-41213 Binding denotes associated
T23435 41219-41222 Protein denotes p65
T23436 41227-41236 Positive_regulation denotes increased
T23437 41241-41244 Protein denotes p65
T23438 41245-41252 Binding denotes binding
T23439 41358-41366 Positive_regulation denotes stronger
T23440 41367-41374 Binding denotes binding
T23441 41378-41381 Protein denotes p65
T23442 41395-41406 Positive_regulation denotes consequence
T23443 41417-41428 Binding denotes association
T23444 41434-41437 Protein denotes Tat
T23445 41452-41458 Positive_regulation denotes caused true
T23446 41476-41482 Regulation denotes change
T23447 41486-41489 Protein denotes p65
T23448 41521-41524 Protein denotes Tat
T23449 41525-41547 Entity denotes cysteine-rich sequence
T23450 41564-41572 Positive_regulation denotes involved
T23451 41580-41587 Binding denotes binding
T23452 41595-41598 Entity denotes RHD
T23453 41602-41605 Protein denotes p65
T23454 41645-41648 Protein denotes Tat
T23455 41649-41671 Entity denotes arginine-rich sequence
T23456 41697-41705 Positive_regulation denotes required
T23457 41697-41705 Positive_regulation denotes required
T23458 41714-41721 Binding denotes binding
T23459 41729-41742 Entity denotes sixth ankyrin
T23460 41746-41751 Protein denotes IκB-α
T23461 41769-41778 Negative_regulation denotes releasing
T23462 41779-41782 Protein denotes p65
T23463 41792-41797 Protein denotes IκB-α
T23464 41798-41808 Negative_regulation denotes inhibition
T23465 41853-41856 Protein denotes Tat
T23466 41912-41921 Binding denotes hijacking
T23467 41926-41931 Protein denotes IκB-α
T23468 41943-41952 Negative_regulation denotes shielding
T23469 41953-41956 Protein denotes p65
T23470 41966-41971 Protein denotes IκB-α
T23471 41972-41979 Binding denotes embrace
T23472 41985-41994 Positive_regulation denotes enforcing
T23473 41999-42002 Protein denotes p65
T23474 42003-42010 Binding denotes binding
T23475 42039-42042 Protein denotes Tat
T23476 42085-42088 Protein denotes Tat
T23477 42102-42113 Protein denotes Tat mutants
T23478 42247-42253 Protein denotes MIP-1α
T23479 42255-42259 Protein denotes CSF3
T23480 42261-42264 Protein denotes LTA
T23481 42266-42272 Protein denotes NFKBIA
T23482 42277-42281 Protein denotes TLR2
T23483 42318-42321 Protein denotes Tat
T23484 42322-42331 Positive_regulation denotes increased
T23485 42336-42347 Binding denotes recruitment
T23486 42351-42354 Protein denotes p65
T23487 42410-42419 Binding denotes recovered
T23488 42443-42455 Negative_regulation denotes interference
T23489 42459-42462 Protein denotes p65
T23490 42463-42472 Negative_regulation denotes abolished
T23491 42477-42480 Protein denotes Tat
T23492 42481-42490 Binding denotes occupancy
T23493 42534-42537 Protein denotes Tat
T23494 42538-42545 Binding denotes binding
T23495 42569-42577 Positive_regulation denotes mediated
T23496 42581-42584 Protein denotes p65
T23497 42639-42642 Protein denotes Tat
T23498 42643-42652 Negative_regulation denotes displaced
T23499 42653-42656 Protein denotes p65
T23500 42666-42673 Binding denotes binding
T23501 42677-42682 Protein denotes IκB-α
T23502 42708-42717 Positive_regulation denotes increased
T23503 42722-42725 Protein denotes p65
T23504 42730-42737 Binding denotes binding
T23505 42755-42766 Binding denotes association
T23506 42792-42795 Protein denotes Tat
T23507 42803-42812 Positive_regulation denotes increased true
T23508 42803-42812 Positive_regulation denotes increased true
T23509 42817-42828 Binding denotes recruitment
T23510 42832-42835 Protein denotes p65
T23511 42872-42883 Binding denotes associating
T23512 42889-42892 Protein denotes p65
T23513 42900-42911 Negative_regulation denotes interfering
T23514 42921-42929 Binding denotes assembly
T23515 42933-42936 Protein denotes p65
T23516 42956-42961 Protein denotes IκB-α
T23517 42976-42981 Protein denotes IκB-α
T23518 42986-42991 Negative_regulation denotes found true
T23519 42992-43002 Binding denotes associated
T23520 43029-43036 Negative_regulation denotes absence
T23521 43040-43043 Protein denotes Tat
T23522 43083-43086 Protein denotes Tat
T23523 43140-43145 Protein denotes IκB-α
T23524 43173-43182 Binding denotes occupancy
T23525 43214-43219 Protein denotes IκB-α
T23526 43230-43240 Binding denotes associated
T23527 43267-43269 Binding denotes at
T23528 43274-43278 Protein denotes hes1
T23529 43279-43287 Entity denotes promoter
T23530 43307-43314 Binding denotes removed true
T23531 43315-43324 Positive_regulation denotes following
T23532 43325-43330 Protein denotes TNF-α
T23533 43343-43350 Positive_regulation denotes causing
T23534 43375-43379 Protein denotes hes1
T23535 43380-43406 Positive_regulation denotes transcriptional activation
T23536 43523-43526 Protein denotes Tat
T23537 43562-43564 Positive_regulation denotes by
T23538 43562-43564 Positive_regulation denotes by
T23539 43565-43573 Binding denotes removing true
T23540 43574-43579 Protein denotes IκB-α
T23541 43584-43593 Positive_regulation denotes promoting
T23542 43598-43601 Protein denotes p65
T23543 43602-43609 Binding denotes loading
T23544 44076-44079 Protein denotes Tat
T23545 44080-44090 Regulation denotes cross talk
T23546 44182-44185 Protein denotes Tat
T23547 44287-44290 Protein denotes Tat
T23548 44324-44329 Protein denotes IκB-α
T23549 44336-44357 Binding denotes coimmunoprecipitation
T23550 44361-44364 Protein denotes Tat
T23551 44370-44375 Protein denotes IκB-α
T23552 44380-44383 Protein denotes p65
T23553 44391-44400 Positive_regulation denotes induction
T23554 44404-44410 Protein denotes MIP-1α
T23555 44411-44421 Gene_expression denotes expression
T23556 44422-44431 Positive_regulation denotes dependent
T23557 44422-44431 Positive_regulation denotes dependent
T23558 44435-44438 Protein denotes Tat
T23559 44443-44446 Protein denotes p65
T23560 44453-44456 Protein denotes Tat
T23561 44457-44466 Binding denotes occupancy
T23562 44474-44480 Protein denotes MIP-1α
T23563 44481-44495 Entity denotes NF-κB enhancer
T23564 44512-44521 Positive_regulation denotes increased
T23565 44522-44533 Binding denotes recruitment
T23566 44537-44540 Protein denotes p65
T23567 44593-44596 Protein denotes Tat
T23568 44614-44625 Binding denotes interaction
T23569 44631-44634 Protein denotes p65
T23570 44639-44644 Protein denotes IκB-α
T23571 44781-44785 Protein denotes IL-6
T23572 44795-44800 Protein denotes TNF-α
T23573 44811-44817 Protein denotes MIP-1α
T23574 44848-44853 Protein denotes TNF-α
T23575 44858-44862 Protein denotes IL-6
T23576 44864-44867 Protein denotes Tat
T23577 44868-44877 Positive_regulation denotes activated
T23578 44868-44877 Positive_regulation denotes activated
T23579 44868-44877 Positive_regulation denotes activated
T23580 44868-44877 Positive_regulation denotes activated
T23581 44868-44877 Positive_regulation denotes activated
T23582 44868-44877 Positive_regulation denotes activated
T23583 44891-44901 Gene_expression denotes expression
T23584 44891-44901 Gene_expression denotes expression
T23585 44905-44912 Binding denotes binding
T23586 44973-44982 Positive_regulation denotes promoting true
T23587 44973-44982 Positive_regulation denotes promoting true
T23588 44987-45013 Transcription denotes transcriptional elongation
T23589 44987-45013 Transcription denotes transcriptional elongation
T23590 45055-45058 Protein denotes Tat
T23591 45147-45155 Binding denotes assembly
T23592 45159-45162 Protein denotes Tat
T23593 45168-45171 Protein denotes p65
T23594 45212-45224 Binding denotes displacement true
T23595 45228-45233 Protein denotes IκB-α
T23596 45299-45302 Protein denotes Tat
T23597 45412-45415 Protein denotes Tat
T23598 46088-46091 Protein denotes Tat
T23599 46123-46134 Binding denotes interaction
T23600 46123-46134 Binding denotes interaction
T23601 46140-46145 Protein denotes IκB-α
T23602 46150-46153 Protein denotes p65
T23603 46175-46185 Negative_regulation denotes inhibitors
T23604 46189-46199 Negative_regulation denotes counteract
T23605 46204-46207 Protein denotes Tat
T24282 16062-16065 Protein denotes Tat
T24283 16194-16203 Protein denotes siRNA Tat
T24284 16342-16345 Protein denotes p24
T24285 16388-16391 Protein denotes Tat
T24286 16392-16402 Gene_expression denotes expression true
T24287 16457-16467 Protein denotes luciferase
T24288 16565-16568 Protein denotes p65
T24289 16573-16576 Protein denotes p50
T24290 16577-16584 Binding denotes binding true
T24291 16577-16584 Binding denotes binding true
T24292 16701-16711 Gene_expression denotes expression true
T24293 16701-16711 Gene_expression denotes expression true
T24294 16715-16718 Protein denotes p65
T24295 16723-16728 Protein denotes IκB-α
T24296 16877-16890 Protein denotes Hexokinase II
T25060 20207-20210 Protein denotes Tat
T25061 20268-20279 Binding denotes associating
T25062 20285-20290 Protein denotes IκB-α
T25063 20382-20385 Protein denotes Tat
T25064 20669-20672 Protein denotes p65
T25065 20674-20677 Protein denotes p50
T25066 20682-20690 Protein denotes FLAG-Tat
T25067 20691-20698 Binding denotes binding true
T25068 20691-20698 Binding denotes binding true
T25069 20691-20698 Binding denotes binding true
T25070 21294-21297 Protein denotes Tat
T25071 21498-21507 Protein denotes protein G
T26333 23400-23403 Protein denotes Tat
T26334 23404-23412 Negative_regulation denotes relieves
T26335 23413-23416 Protein denotes p65
T26336 23426-23431 Protein denotes IκB-α
T26337 23432-23442 Negative_regulation denotes inhibition
T26338 23497-23500 Protein denotes Tat
T26339 23515-23523 Protein denotes HA-IκB-α
T26340 23571-23579 Protein denotes FLAG-Tat
T26341 23581-23601 Protein denotes FLAG-Tat T,N(23,24)A
T26342 23603-23621 Protein denotes FLAG-Tat K(50,51)A
T26343 23623-23641 Protein denotes FLAG-Tat R(49–57)A
T26344 23645-23666 Protein denotes FLAG-Tat C(22,25,27)A
T26345 23732-23735 Protein denotes Tat
T26346 23940-23943 Protein denotes p65
T26347 23990-23998 Protein denotes HA-IκB-α
T26348 24032-24040 Protein denotes FLAG-Tat
T26349 24044-24062 Protein denotes FLAG-Tat R(49–57)A
T26350 24081-24089 Protein denotes HA-IκB-α
T26351 24283-24286 Protein denotes p65
T26352 24394-24397 Protein denotes p65
T26353 24402-24409 Binding denotes binding true
T26354 24545-24548 Protein denotes p65
T26355 24584-24592 Protein denotes HA-IκB-α
T26356 24601-24609 Protein denotes FLAG-Tat
T26357 24613-24631 Protein denotes FLAG-Tat R(49–57)A
T26358 24647-24658 Negative_regulation denotes competition true
T26359 24666-24673 Binding denotes binding
T26360 24861-24864 Protein denotes p50
T26361 24867-24870 Protein denotes p65
T26362 24940-24945 Protein denotes β-Gal
T26363 24979-24982 Protein denotes p65
T26364 24999-25007 Protein denotes HA-IκB-α
T26365 25026-25029 Protein denotes Tat
T26366 25041-25044 Protein denotes Tat
T26367 25078-25088 Protein denotes luciferase
T26368 25169-25184 Protein denotes β-galactosidase
T27104 27379-27382 Protein denotes Tat
T27105 27383-27393 Binding denotes associates
T27106 27399-27402 Protein denotes p65
T27107 27403-27413 Positive_regulation denotes increasing
T27108 27431-27438 Binding denotes binding
T27109 27485-27493 Protein denotes 3xHA-p65
T27110 27535-27538 Protein denotes Tat
T27111 27548-27563 Protein denotes Tat T,N(23,24)A
T27112 27573-27586 Protein denotes Tat K(50,51)A
T27113 27596-27609 Protein denotes Tat R(49–57)A
T27114 27622-27638 Protein denotes Tat C(22,25,27)A
T27115 27647-27655 Protein denotes FLAG-Tat
T27116 27856-27859 Protein denotes p65
T27117 27886-27893 Protein denotes GST-Tat
T27118 27895-27914 Protein denotes GST-Tat T,N(23,24)A
T27119 27916-27933 Protein denotes GST-Tat K(50,51)A
T27120 27935-27952 Protein denotes GST-Tat R(49–57)A
T27121 27954-27974 Protein denotes GST-Tat C(22,25,27)A
T27122 27979-27982 Protein denotes GST
T27123 28065-28068 Protein denotes GST
T27124 28231-28234 Protein denotes p65
T27125 28290-28293 Protein denotes Tat
T27126 28339-28347 Protein denotes 3xHA-p65
T27127 28357-28367 Protein denotes 3xHA-p65ΔC
T27128 28388-28398 Protein denotes 3xHA-p65ΔN
T27129 28438-28444 Protein denotes HA-p65
T27130 28635-28638 Protein denotes p65
T27131 28810-28818 Protein denotes FLAG-Tat
T27132 28822-28843 Protein denotes FLAG-Tat C(22,25,27)A
T28144 31394-31397 Protein denotes Tat
T28145 31412-31415 Protein denotes p65
T28146 31466-31475 Binding denotes occupying
T28147 31500-31509 Positive_regulation denotes promoting
T28148 31500-31509 Positive_regulation denotes promoting
T28149 31514-31517 Protein denotes p65
T28150 31518-31529 Binding denotes recruitment
T28151 31535-31540 Protein denotes IκB-α
T28152 31541-31553 Binding denotes displacement true
T28153 31606-31609 Protein denotes Tat
T28154 31619-31634 Protein denotes Tat C(22,25,27)
T28155 31644-31656 Protein denotes Tat R(49–57)
T28156 31686-31689 Protein denotes p65
T28157 31694-31706 Negative_regulation denotes interference
T28158 31754-31757 Protein denotes Tat
T28159 31770-31779 Protein denotes siRNA p65
T28160 31915-31925 Gene_expression denotes expression true
T28161 31915-31925 Gene_expression denotes expression true
T28162 31915-31925 Gene_expression denotes expression true
T28163 31915-31925 Gene_expression denotes expression true
T28164 31915-31925 Gene_expression denotes expression true
T28165 31915-31925 Gene_expression denotes expression true
T28166 31915-31925 Gene_expression denotes expression true
T28167 31929-31935 Protein denotes MIP-1α
T28168 31941-31945 Protein denotes CSF3
T28169 31951-31954 Protein denotes LTA
T28170 31960-31966 Protein denotes NFKBIA
T28171 31972-31976 Protein denotes TLR2
T28172 31982-31987 Protein denotes GAPDH
T28173 31993-31997 Protein denotes ACTB
T28174 32064-32067 Protein denotes Tat
T28175 32302-32305 Protein denotes Tat
T28176 32340-32349 Protein denotes siRNA p65
T28177 32584-32587 Protein denotes Tat
T28178 32618-32629 Protein denotes siRNA IκB-α
T28984 35900-35903 Protein denotes Tat
T28985 35936-35944 Positive_regulation denotes enhances
T28986 35949-35955 Protein denotes MIP-1α
T28987 35956-35966 Gene_expression denotes expression
T28988 35971-35982 Binding denotes interaction
T28989 35988-35993 Protein denotes IκB-α
T28990 35998-36001 Protein denotes p65
T28991 36046-36055 Protein denotes siRNA Tat
T28992 36163-36171 Protein denotes FLAG-Tat
T28993 36196-36199 Protein denotes p24
T28994 36282-36285 Protein denotes Tat
T28995 36286-36296 Gene_expression denotes expression true
T28996 36327-36330 Protein denotes p24
T28997 36363-36370 Binding denotes binding true
T28998 36374-36377 Protein denotes p65
T28999 36535-36540 Protein denotes IκB-α
T29000 36943-36951 Protein denotes FLAG-Tat
T29001 37069-37078 Protein denotes protein G
T29002 37296-37305 Protein denotes siRNA Tat
T29003 37307-37316 Protein denotes siRNA p65
T29004 37425-37433 Protein denotes FLAG-Tat
T29005 37528-37534 Protein denotes MIP-1α
T29006 37535-37545 Gene_expression denotes expression true
T29007 37617-37626 Protein denotes siRNA Tat
T29008 37737-37745 Protein denotes FLAG-Tat
T29009 37922-37928 Protein denotes MIP-1α
T29010 37933-37938 Protein denotes GAPDH
T29372 43641-43647 Protein denotes MIP-1α
T29373 43648-43663 Transcription denotes transcriptional
T29374 43664-43674 Positive_regulation denotes activation
T29375 43684-43687 Protein denotes Tat
T29376 43696-43703 Negative_regulation denotes absence
T29377 43707-43710 Protein denotes Tat
T29378 43712-43717 Protein denotes IκB-α
T29379 43718-43726 Binding denotes occupies
T29380 43731-43745 Entity denotes NF-κB enhancer
T29381 43753-43759 Protein denotes MIP-1α
T29382 43780-43789 Binding denotes interacts true
T29383 43878-43881 Protein denotes Tat
T29384 43882-43891 Positive_regulation denotes activates
T29385 43896-43902 Protein denotes MIP-1α
T29386 43903-43913 Gene_expression denotes expression
T29387 43917-43925 Negative_regulation denotes removing
T29388 43930-43935 Protein denotes IκB-α
T29389 43978-43988 Positive_regulation denotes increasing
T29390 43993-44000 Binding denotes binding
T29391 44029-44043 Entity denotes NF-κB enhancer
T858 31-34 Protein denotes Tat
T859 64-75 Binding denotes interaction
T860 81-86 Protein denotes IκB-α
T861 91-94 Protein denotes p65
T862 439-442 Protein denotes Tat
T863 477-486 Binding denotes hijacking
T864 501-506 Protein denotes IκB-α
T865 514-524 Negative_regulation denotes preventing
T866 539-546 Binding denotes binding
T867 579-582 Protein denotes Tat
T868 583-593 Binding denotes associated
T869 603-606 Protein denotes p65
T870 628-637 Positive_regulation denotes increased
T871 642-645 Protein denotes p65
T872 650-657 Binding denotes binding
T873 740-743 Protein denotes Tat
T874 749-757 Positive_regulation denotes required
T875 749-757 Positive_regulation denotes required
T876 762-767 Protein denotes IκB-α
T877 772-775 Protein denotes p65
T878 776-787 Binding denotes association
T879 866-876 Positive_regulation denotes responsive
T880 884-887 Protein denotes Tat
T882 909-915 Protein denotes MIP-1α
T11064 15359-15362 Protein denotes Env
T11065 15538-15548 Gene_expression denotes expression
T11066 15552-15555 Protein denotes Tat
T11067 15609-15618 Positive_regulation denotes increased
T11068 15697-15712 Negative_regulation denotes barely detected
T11069 15716-15725 Protein denotes siRNA Tat
T11070 15765-15774 Positive_regulation denotes dependent
T11071 15775-15785 Protein denotes luciferase
T11072 15786-15796 Gene_expression denotes expression
T6014 8544-8559 Protein denotes siRNA Tat sense
T17286 30629-30635 Protein denotes MIP-1α
T6015 8587-8606 Protein denotes siRNA Tat antisense
T5634 7993-8003 Protein denotes luciferase
T5635 8016-8031 Protein denotes β-galactosidase
T6016 8731-8743 Negative_regulation denotes interference
T6017 8731-8743 Negative_regulation denotes interference
T6018 8747-8750 Protein denotes p65
T6019 8755-8760 Protein denotes IκB-α
T6020 8791-8800 Protein denotes siRNA p65
T6021 8805-8810 Protein denotes IκB-α
T6264 8964-8967 Protein denotes Tat
T6265 9001-9004 Protein denotes Env
T6266 9232-9235 Protein denotes Env
T6267 9267-9270 Protein denotes p24
T6665 10612-10619 Binding denotes Binding true
T6666 10612-10619 Binding denotes Binding true
T6667 10612-10619 Binding denotes Binding true
T6668 10623-10626 Protein denotes p65
T6669 10628-10631 Protein denotes p50
T6670 10636-10644 Protein denotes FLAG-Tat
T6850 10954-10962 Protein denotes HA-IκB-α
T6851 10964-10967 Protein denotes p65
T6852 10972-10975 Protein denotes Tat
T6853 10981-10990 Gene_expression denotes expressed
T6854 10981-10990 Gene_expression denotes expressed
T6855 10981-10990 Gene_expression denotes expressed
T6856 10991-10996 Positive_regulation denotes under
T6857 10991-10996 Positive_regulation denotes under
T6858 10991-10996 Positive_regulation denotes under
T6971 11214-11217 Protein denotes GST
T6972 11249-11252 Protein denotes GST
T6973 11282-11285 Protein denotes GST
T7461 11934-11937 Protein denotes Tat
T7462 11942-11948 Protein denotes MIP-1α
T7463 12000-12004 Protein denotes CSF3
T7464 12006-12009 Protein denotes LTA
T7465 12011-12017 Protein denotes NFKBIA
T7466 12019-12023 Protein denotes TLR2
T7467 12025-12030 Protein denotes GAPDH
T7468 12035-12039 Protein denotes ACTB
T7469 12242-12247 Protein denotes GAPDH
T7470 12253-12259 Transcription denotes levels
T7471 12356-12361 Protein denotes GAPDH
R3990 T4127 T4128 themeOf Tat,binds
R616 T883 T885 themeOf expression,dependent
R617 T884 T885 causeOf p65,dependent
R618 T885 T881 themeOf dependent,activated
R619 T886 T889 causeOf bound,promoting
R620 T886 T890 causeOf bound,promoting
R621 T888 T886 themeOf NF-κB enhancer,bound
R622 T888 T887 partOf NF-κB enhancer,MIP-1α
R623 T888 T891 themeOf NF-κB enhancer,recruitment
R624 T891 T889 themeOf recruitment,promoting
R625 T892 T891 themeOf p65,recruitment
R626 T892 T893 themeOf p65,displacement
R627 T893 T890 themeOf displacement,promoting
R628 T894 T893 themeOf IκB-α,displacement
R629 T900 T899 themeOf Tat,interaction
R630 T901 T899 themeOf IκB-α,interaction
R741 T858 T859 themeOf Tat,interaction
R742 T860 T859 themeOf IκB-α,interaction
R743 T862 T863 themeOf Tat,hijacking
R744 T862 T865 causeOf Tat,preventing
R745 T864 T863 themeOf IκB-α,hijacking
R746 T864 T866 themeOf IκB-α,binding
R747 T866 T865 themeOf binding,preventing
R748 T867 T868 themeOf Tat,associated
R749 T867 T870 causeOf Tat,increased
R750 T869 T868 themeOf p65,associated
R751 T871 T872 themeOf p65,binding
R752 T872 T870 themeOf binding,increased
R753 T873 T878 themeOf Tat,association
R754 T876 T874 themeOf IκB-α,required
R755 T876 T878 themeOf IκB-α,association
R756 T877 T875 themeOf p65,required
R757 T880 T881 causeOf Tat,activated
R758 T880 T886 themeOf Tat,bound
R759 T882 T879 themeOf MIP-1α,responsive
R760 T882 T883 themeOf MIP-1α,expression
R3633 T3998 T4057 themeOf RelA,dimerization
R3636 T3998 T4062 themeOf RelA,binding
R3639 T3999 T3998 equivalentTo p65,RelA
R3640 T4000 T4056 themeOf c-Rel,dimerization
R3641 T4000 T4060 themeOf c-Rel,binding
R3643 T4001 T4059 themeOf RelB,dimerization
R3644 T4001 T4061 themeOf RelB,binding
R3646 T4002 T4063 themeOf p50,binding
R3647 T4002 T4058 themeOf p50,dimerization
R3648 T4003 T4064 themeOf p52,binding
R3649 T4003 T4055 themeOf p52,dimerization
R3652 T4004 T4032 causeOf Rel homology domain,for
R3653 T4004 T4031 causeOf Rel homology domain,for
R3654 T4004 T4030 causeOf Rel homology domain,for
R3655 T4004 T4029 causeOf Rel homology domain,for
R3656 T4004 T4028 causeOf Rel homology domain,for
R3657 T4004 T4005 causeOf Rel homology domain,for
R3658 T4004 T4025 causeOf Rel homology domain,for
R3659 T4004 T4024 causeOf Rel homology domain,for
R3660 T4004 T4023 causeOf Rel homology domain,for
R3661 T4004 T4022 causeOf Rel homology domain,for
R3662 T4004 T4020 causeOf Rel homology domain,for
R3663 T4004 T4019 causeOf Rel homology domain,for
R3664 T4004 T4018 causeOf Rel homology domain,for
R3665 T4004 T4017 causeOf Rel homology domain,for
R3666 T4004 T4012 causeOf Rel homology domain,for
R3667 T4004 T3998 partOf Rel homology domain,RelA
R3668 T4004 T4011 causeOf Rel homology domain,for
R3669 T4004 T4000 partOf Rel homology domain,c-Rel
R3670 T4004 T4010 causeOf Rel homology domain,for
R3671 T4004 T4001 partOf Rel homology domain,RelB
R3672 T4004 T4008 causeOf Rel homology domain,for
R3673 T4004 T4002 partOf Rel homology domain,p50
R3674 T4004 T4007 causeOf Rel homology domain,for
R3675 T4004 T4003 partOf Rel homology domain,p52
R3676 T4004 T4006 causeOf Rel homology domain,for
R3677 T4004 T4026 causeOf Rel homology domain,for
R3678 T4004 T4045 causeOf Rel homology domain,for
R3679 T4004 T4054 causeOf Rel homology domain,for
R3680 T4004 T4009 causeOf Rel homology domain,for
R3681 T4004 T4013 causeOf Rel homology domain,for
R3682 T4004 T4014 causeOf Rel homology domain,for
R3683 T4004 T4015 causeOf Rel homology domain,for
R3684 T4004 T4016 causeOf Rel homology domain,for
R3685 T4004 T4021 causeOf Rel homology domain,for
R3686 T4004 T4027 causeOf Rel homology domain,for
R3687 T4004 T4033 causeOf Rel homology domain,for
R3688 T4004 T4051 causeOf Rel homology domain,for
R3689 T4004 T4039 causeOf Rel homology domain,for
R3690 T4004 T4053 causeOf Rel homology domain,for
R3691 T4004 T4052 causeOf Rel homology domain,for
R3692 T4004 T4050 causeOf Rel homology domain,for
R3693 T4004 T4049 causeOf Rel homology domain,for
R3694 T4004 T4048 causeOf Rel homology domain,for
R3695 T4004 T4047 causeOf Rel homology domain,for
R3696 T4004 T4046 causeOf Rel homology domain,for
R3697 T4004 T4044 causeOf Rel homology domain,for
R3698 T4004 T4043 causeOf Rel homology domain,for
R3699 T4004 T4042 causeOf Rel homology domain,for
R3700 T4004 T4041 causeOf Rel homology domain,for
R3701 T4004 T4040 causeOf Rel homology domain,for
R3702 T4004 T4038 causeOf Rel homology domain,for
R3703 T4004 T4037 causeOf Rel homology domain,for
R3704 T4004 T4036 causeOf Rel homology domain,for
R3705 T4004 T4035 causeOf Rel homology domain,for
R3706 T4004 T4034 causeOf Rel homology domain,for
R3707 T4055 T4052 themeOf dimerization,for
R3708 T4055 T4050 themeOf dimerization,for
R3709 T4055 T4049 themeOf dimerization,for
R3710 T4055 T4048 themeOf dimerization,for
R3711 T4055 T4047 themeOf dimerization,for
R3712 T4056 T4006 themeOf dimerization,for
R3713 T4056 T4026 themeOf dimerization,for
R3714 T4056 T4045 themeOf dimerization,for
R3715 T4056 T4054 themeOf dimerization,for
R3716 T4056 T4009 themeOf dimerization,for
R3717 T4057 T4012 themeOf dimerization,for
R3718 T4057 T4011 themeOf dimerization,for
R3719 T4057 T4010 themeOf dimerization,for
R3720 T4057 T4008 themeOf dimerization,for
R3721 T4057 T4007 themeOf dimerization,for
R3722 T4058 T4027 themeOf dimerization,for
R3723 T4058 T4033 themeOf dimerization,for
R3724 T4058 T4051 themeOf dimerization,for
R3725 T4152 T4143 themeOf CDK9,interacting
R3726 T4058 T4039 themeOf dimerization,for
R3727 T4153 T4144 themeOf p300,interacting
R3728 T4058 T4053 themeOf dimerization,for
R3729 T4154 T4146 themeOf CBP,interacting
R3730 T4059 T4013 themeOf dimerization,for
R3731 T4155 T4145 themeOf P/CAF,interacting
R3732 T4157 T4156 themeOf Tat,released
R3733 T4157 T4158 themeOf Tat,binding
R3734 T4059 T4014 themeOf dimerization,for
R3735 T4161 T4160 themeOf Tat,expressed
R3736 T4059 T4015 themeOf dimerization,for
R3737 T4162 T4163 causeOf Tat,induced
R3738 T4162 T4167 causeOf Tat,inhibiting
R3739 T4059 T4016 themeOf dimerization,for
R3740 T4164 T4163 themeOf degradation,induced
R3741 T4059 T4021 themeOf dimerization,for
R3742 T4165 T4164 themeOf IκB-α,degradation
R3743 T4060 T4040 themeOf binding,for
R3744 T4168 T4169 causeOf SIRT-1,mediated
R3745 T4060 T4038 themeOf binding,for
R3746 T4169 T4167 themeOf mediated,inhibiting
R3747 T4170 T4169 themeOf deacetylation,mediated
R3748 T4060 T4037 themeOf binding,for
R3749 T4060 T4036 themeOf binding,for
R3750 T4172 T4170 themeOf Lys310,deacetylation
R3751 T4172 T4171 partOf Lys310,p65
R3752 T4060 T4035 themeOf binding,for
R3753 T4061 T4032 themeOf binding,for
R3754 T4176 T4175 themeOf IκB-α,synthesis
R3755 T4061 T4031 themeOf binding,for
R3756 T4177 T4178 themeOf IκB-α,binds
R3757 T4061 T4030 themeOf binding,for
R3758 T4179 T4178 themeOf Tat,binds
R3759 T4061 T4029 themeOf binding,for
R3760 T4180 T4181 themeOf Tat,interaction
R3761 T4061 T4034 themeOf binding,for
R3762 T4182 T4181 themeOf IκB-α,interaction
R3763 T4062 T4046 themeOf binding,for
R3764 T4062 T4044 themeOf binding,for
R3765 T4062 T4043 themeOf binding,for
R3766 T4062 T4042 themeOf binding,for
R3767 T4062 T4041 themeOf binding,for
R3768 T4063 T4028 themeOf binding,for
R3769 T4063 T4005 themeOf binding,for
R3770 T4063 T4025 themeOf binding,for
R3771 T4063 T4024 themeOf binding,for
R3772 T4063 T4023 themeOf binding,for
R3773 T4064 T4022 themeOf binding,for
R3774 T4064 T4020 themeOf binding,for
R3775 T4064 T4019 themeOf binding,for
R3777 T4064 T4018 themeOf binding,for
R3778 T4064 T4017 themeOf binding,for
R3779 T4068 T4077 themeOf IκB-α,degraded
R3780 T4071 T4070 themeOf Ser32,phosphorylated
R3787 T4071 T4068 partOf Ser32,IκB-α
R3788 T4072 T4069 themeOf Ser36,phosphorylated
R3790 T4072 T4068 partOf Ser36,IκB-α
R3796 T4075 T4073 themeOf Lys21,ubiquitylated
R3799 T4075 T4068 partOf Lys21,IκB-α
R3801 T4076 T4074 themeOf Lys22,ubiquitylated
R3802 T4076 T4068 partOf Lys22,IκB-α
R3803 T4077 T4078 themeOf degraded,by
R3806 T4079 T4084 themeOf phosphorylation,by
R3809 T4079 T4087 themeOf phosphorylation,by
R3810 T4079 T4090 themeOf phosphorylation,by
R3814 T4083 T4079 themeOf Ser276,phosphorylation
R3819 T4083 T4082 partOf Ser276,p65
R3822 T4085 T4084 causeOf MSK1,by
R3826 T4086 T4081 themeOf Ser311,phosphorylation
R3829 T4086 T4082 partOf Ser311,p65
R3831 T4088 T4087 causeOf PKCζ,by
R3833 T4089 T4080 themeOf Ser536,phosphorylation
R3840 T4089 T4082 partOf Ser536,p65
R3841 T4091 T4090 causeOf IKKα,by
R3844 T4092 T4098 causeOf Acetylation,increases
R3846 T4092 T4100 causeOf Acetylation,impairs
R3847 T4093 T4097 causeOf Acetylation,increases
R3848 T4093 T4101 causeOf Acetylation,impairs
R3849 T4094 T4099 themeOf p65,binding
R3852 T4094 T4102 themeOf p65,association
R3853 T4095 T4092 themeOf Lys218,Acetylation
R3857 T4095 T4094 partOf Lys218,p65
R3859 T4096 T4093 themeOf Lys221,Acetylation
R3862 T4096 T4094 partOf Lys221,p65
R3864 T4099 T4098 themeOf binding,increases
R3881 T4099 T4097 themeOf binding,increases
R3882 T4102 T4100 themeOf association,impairs
R3884 T4102 T4101 themeOf association,impairs
R3885 T4103 T4102 themeOf IκB-α,association
R3886 T4105 T4104 themeOf Lys310,acetylation
R3947 T4105 T4094 partOf Lys310,p65
R3948 T4111 T4110 themeOf p65,Deacetylation
R3949 T4111 T4109 themeOf p65,Deacetylation
R3950 T4112 T4110 causeOf histone deacetylase-3,Deacetylation
R3951 T4113 T4109 causeOf SIRT1,Deacetylation
R3957 T4117 T4114 themeOf Lys122,acetylation
R3959 T4117 T4116 partOf Lys122,p65
R3967 T4118 T4115 themeOf Lys123,acetylation
R3969 T4118 T4116 partOf Lys123,p65
R3970 T4119 T4122 causeOf binding,induces
R3973 T4120 T4119 themeOf gp120,binding
R3974 T4121 T4119 themeOf CD4,binding
R3975 T4123 T4122 themeOf activation,induces
R3979 T4124 T4123 themeOf procaspase 8,activation
R3987 T4125 T4126 themeOf Tat,interacts
R3992 T4128 T4134 causeOf binds,activate
R3993 T4128 T4133 causeOf binds,activate
R3994 T4129 T4135 themeOf tumor necrosis factor β,transcription
R3995 T4130 T4129 equivalentTo TNFβ,tumor necrosis factor β
R3996 T4131 T4136 themeOf interleukin-6,transcription
R3997 T4132 T4131 equivalentTo IL-6,interleukin-6
R3998 T4135 T4134 themeOf transcription,activate
R3999 T4136 T4133 themeOf transcription,activate
R4000 T4137 T4139 themeOf Tat,interacting
R4001 T4137 T4141 themeOf Tat,interacting
R4002 T4137 T4140 themeOf Tat,interacting
R4003 T4137 T4138 themeOf Tat,interacting
R4004 T4137 T4142 themeOf Tat,interacting
R4005 T4137 T4143 themeOf Tat,interacting
R4006 T4137 T4144 themeOf Tat,interacting
R4007 T4137 T4146 themeOf Tat,interacting
R4008 T4137 T4145 themeOf Tat,interacting
R4009 T4147 T4139 themeOf Sp1,interacting
R4010 T4148 T4141 themeOf TFIID,interacting
R4011 T4149 T4140 themeOf E2F-4,interacting
R4012 T4150 T4138 themeOf C/EBPβ,interacting
R4013 T4151 T4142 themeOf cyclin T1,interacting
R9042 T11057 T11058 themeOf Tat,hijacking
R9044 T11059 T11058 themeOf IκB-α,hijacking
R9046 T11061 T11060 themeOf expression,modulating
R9047 T11062 T11061 themeOf Tat,expression
R9050 T11065 T11067 themeOf expression,increased
R9051 T11065 T11068 themeOf expression,barely detected
R9052 T11066 T11065 themeOf Tat,expression
R9056 T11069 T11068 causeOf siRNA Tat,barely detected
R9058 T11070 T11073 themeOf dependent,induced
R9059 T11071 T11072 themeOf luciferase,expression
R9060 T11072 T11070 themeOf expression,dependent
R9065 T11076 T11079 themeOf p65,binding
R9067 T11077 T11078 themeOf p50,binding
R9071 T11084 T11085 themeOf p65,binding
R9072 T11085 T11088 themeOf binding,elevated
R9073 T11085 T11090 themeOf binding,dropped
R9074 T11086 T11087 themeOf p65,elevated
R9075 T11086 T11091 themeOf p65,dropped
R9078 T11089 T11088 causeOf Tat,elevated
R9079 T11089 T11087 causeOf Tat,elevated
R9080 T11092 T11090 causeOf absence,dropped
R9081 T11092 T11091 causeOf absence,dropped
R9082 T11093 T11092 themeOf Tat,absence
R9084 T11095 T11096 themeOf IκB-α,degraded
R9085 T11095 T11097 themeOf IκB-α,synthesized
R9090 T11101 T11102 themeOf IκB-α,degradation
R9091 T11101 T11103 themeOf IκB-α,re-synthesis
R9092 T11102 T11105 themeOf degradation,observed
R9093 T11103 T11104 themeOf re-synthesis,observed
R9095 T11106 T11107 themeOf IκB-α,degradation
R9096 T11111 T11110 themeOf IκB-α,synthesis
R9098 T11114 T11115 themeOf p65,binding
R9100 T11115 T11117 themeOf binding,enhanced
R9102 T11116 T11118 themeOf p65,enhanced
R9104 T11119 T11117 causeOf Tat,enhanced
R9105 T11119 T11118 causeOf Tat,enhanced
R9106 T11119 T11121 causeOf Tat,affected
R9107 T11120 T11121 themeOf IκB-α,affected
R9108 T11122 T11124 themeOf increased,independently
R9110 T11123 T11122 themeOf p65,increased
R9111 T11125 T11124 causeOf Tat,independently
R9112 T11126 T11127 themeOf p65,binding
R9113 T11127 T11129 themeOf binding,elevated
R9114 T11127 T11132 themeOf binding,dropped
R9116 T11128 T11130 themeOf p65,elevated
R9117 T11128 T11133 themeOf p65,dropped
R9118 T11131 T11129 causeOf Tat,elevated
R9119 T11131 T11130 causeOf Tat,elevated
R9121 T11134 T11135 themeOf Tat,negative
R9123 T11135 T11132 causeOf negative,dropped
R9124 T11135 T11133 causeOf negative,dropped
R9125 T11136 T11137 themeOf Tat,bound
R9126 T11136 T11138 themeOf Tat,binding
R9127 T11138 T11139 themeOf binding,increased
R9129 T11140 T11142 themeOf Degradation,induced
R9131 T11141 T11140 themeOf IκB-α,Degradation
R9132 T11141 T11144 themeOf IκB-α,synthesis
R9133 T11142 T11143 causeOf induced,followed
R9134 T11144 T11143 themeOf synthesis,followed
R9136 T11147 T11148 causeOf Tat,affecting
R9138 T11149 T11148 themeOf IκB-α,affecting
R9139 T11150 T11151 themeOf Tat,binds
R9141 T11152 T11151 themeOf sixth ankyrin,binds
R9142 T11152 T11153 partOf sixth ankyrin,IκB-α
R9143 T11154 T11155 causeOf Tat,counteracted
R9145 T11156 T11155 themeOf generation,counteracted
R9146 T11157 T11156 themeOf IκB-α,generation
R9147 T11159 T11158 themeOf IκB-α,association
R9148 T11160 T11158 themeOf p65,association
R9150 T11162 T11161 themeOf IκB-α,synthesis
R9151 T11163 T11167 themeOf Coimmunoprecipitation,halved
R9152 T11164 T11163 themeOf IκB-α,Coimmunoprecipitation
R9153 T11165 T11163 themeOf p65,Coimmunoprecipitation
R9157 T11168 T11167 causeOf Tat,halved
R9158 T11169 T11170 themeOf Tat,coimmunoprecipitated
R9160 T11171 T11170 themeOf IκB-α,coimmunoprecipitated
R9161 T11172 T11173 causeOf Tat,competed
R9162 T11174 T11175 themeOf IκB-α,binding
R9164 T11175 T11173 themeOf binding,competed
R9165 T11176 T11175 themeOf p65,binding
R10487 T12909 T12914 causeOf Tat,competing
R10488 T12911 T12915 themeOf IκB-α,binding
R10489 T12911 T12912 causeOf IκB-α,inhibition
R10490 T12912 T12910 themeOf inhibition,counteracts
R10491 T12913 T12912 themeOf p65,inhibition
R10492 T12914 T12910 causeOf competing,counteracts
R10493 T12915 T12914 themeOf binding,competing
R10494 T12917 T12916 themeOf Tat,interaction
R10495 T12918 T12916 themeOf IκB-α,interaction
R10496 T12924 T12926 themeOf IκB-α,coimmunoprecipitated
R10497 T12924 T12925 themeOf IκB-α,coimmunoprecipitated
R10498 T12927 T12926 themeOf Tat,coimmunoprecipitated
R10499 T12928 T12925 themeOf Tat R(49–57)A,coimmunoprecipitated
R10500 T12929 T12931 causeOf arginine-rich domain,involved
R10501 T12929 T12930 partOf arginine-rich domain,Tat
R10502 T12930 T12932 themeOf Tat,binding
R10503 T12932 T12931 themeOf binding,involved
R10504 T12933 T12932 themeOf IκB-α,binding
R10505 T12934 T12935 themeOf Tat,associating
R10506 T12935 T12937 causeOf associating,competed
R10507 T12936 T12935 themeOf IκB-α,associating
R10508 T12938 T12937 themeOf binding,competed
R10509 T12939 T12938 themeOf IκB-α,binding
R10510 T12940 T12938 themeOf p65,binding
R10511 T12941 T12946 themeOf Tat R(49–57)A,associate
R10512 T12941 T12948 causeOf Tat R(49–57)A,compete
R10513 T12944 T12942 themeOf site,lacked
R10514 T12944 T12934 partOf site,Tat
R10515 T12944 T12943 themeOf site,binding
R10516 T12945 T12943 themeOf IκB-α,binding
R10517 T12947 T12946 themeOf IκB-α,associate
R10518 T12949 T12948 themeOf binding,compete
R10519 T12950 T12949 themeOf IκB-α,binding
R10520 T12951 T12949 themeOf p65,binding
R10521 T12952 T12953 causeOf Tat,counteracted
R10522 T12954 T12955 causeOf IκB-α,inhibition
R10523 T12955 T12953 themeOf inhibition,counteracted
R10524 T12956 T12957 themeOf p65,binding
R10525 T12957 T12955 themeOf binding,inhibition
R10526 T12961 T12962 themeOf p65,binding
R10527 T12962 T12963 themeOf binding,inhibited
R10528 T12963 T12966 themeOf inhibited,restored
R10529 T12963 T12965 themeOf inhibited,restored
R10530 T12964 T12963 causeOf IκB-α,inhibited
R10531 T12967 T12966 causeOf Tat,restored
R10532 T12968 T12965 causeOf Tat R(49–57),restored
R10533 T12978 T12979 causeOf IκB-α,inhibited
R10534 T12979 T12984 themeOf inhibited,restored
R10535 T12979 T12985 themeOf inhibited,restored
R10536 T12980 T12981 causeOf p65,dependent
R10537 T12981 T12979 themeOf dependent,inhibited
R10538 T12982 T12981 themeOf expression,dependent
R10539 T12983 T12982 themeOf luciferase,expression
R10540 T12986 T12984 causeOf Tat,restored
R10541 T12987 T12985 causeOf Tat R(49–57)A,restored
R10542 T12988 T12995 themeOf Tat,associating
R10543 T12988 T12997 causeOf Tat,competing
R10544 T12991 T12992 causeOf IκB-α,repression
R10545 T12992 T12989 themeOf repression,counteracts
R10546 T12992 T12990 themeOf repression,counteracts
R10547 T12993 T12994 themeOf p65,binding
R10548 T12994 T12992 themeOf binding,repression
R10549 T12995 T12989 causeOf associating,counteracts
R10550 T12996 T12995 themeOf IκB-α,associating
R10551 T12996 T12998 themeOf IκB-α,binding
R10552 T12997 T12990 causeOf competing,counteracts
R10553 T12998 T12997 themeOf binding,competing
R10554 T12999 T12998 themeOf p65,binding
R11791 T14678 T14682 themeOf Tat,association
R11792 T14680 T14681 themeOf p65,binding
R11793 T14681 T14679 themeOf binding,increases
R11794 T14682 T14679 causeOf association,increases
R11795 T14683 T14682 themeOf p65,association
R11796 T14684 T14685 themeOf Tat,interacted
R11797 T14686 T14685 themeOf p65,interacted
R11798 T14689 T14690 themeOf Tat,immunoprecipitated
R11799 T14691 T14692 themeOf p65,coimmunoprecipitated
R11800 T14691 T14698 themeOf p65,coimmunoprecipitation
R11801 T14693 T14692 themeOf Tat,coimmunoprecipitated
R11802 T14698 T14697 themeOf coimmunoprecipitation,decrease
R11803 T14699 T14697 causeOf "Tat C(22,25,27)A",decrease
R11804 T14699 T14698 themeOf "Tat C(22,25,27)A",coimmunoprecipitation
R11805 T14702 T14701 themeOf p65,binding
R11806 T14702 T14707 themeOf p65,binding
R11807 T14703 T14701 themeOf Tat,binding
R11808 T14708 T14707 themeOf "Tat C(22,25,27)A",binding
R11809 T14710 T14713 themeOf associated,mediate
R11810 T14711 T14710 themeOf p65,associated
R11811 T14712 T14710 themeOf cysteine-rich domain,associated
R11812 T14712 T14709 partOf cysteine-rich domain,Tat
R11813 T14714 T14717 themeOf p65,binding
R11814 T14715 T14716 causeOf domain,required
R11815 T14715 T14714 partOf domain,p65
R11816 T14717 T14716 themeOf binding,required
R11817 T14718 T14717 themeOf Tat,binding
R11818 T14723 T14722 themeOf transactivation domain,deleted
R11819 T14723 T14714 partOf transactivation domain,p65
R11820 T14725 T14721 themeOf RHD,deleted
R11821 T14725 T14714 partOf RHD,p65
R11822 T14727 T14728 themeOf Tat,coimmunoprecipitated
R11823 T14729 T14728 themeOf p65ΔC (1–318),coimmunoprecipitated
R11824 T14731 T14733 themeOf RHD,interaction
R11825 T14731 T14732 partOf RHD,p65
R11826 T14734 T14733 themeOf Tat,interaction
R11827 T14736 T14735 causeOf Tat,effect
R11828 T14737 T14738 themeOf p65,binding
R11829 T14738 T14735 themeOf binding,effect
R11830 T14742 T14743 themeOf p65,binding
R11831 T14744 T14745 causeOf Tat,increased
R11832 T14746 T14745 themeOf binding,increased
R11833 T14746 T14753 themeOf binding,ineffective
R11834 T14747 T14746 themeOf p65,binding
R11835 T14748 T14753 causeOf "Tat C(22,25,27)A",ineffective
R11836 T14751 T14749 themeOf site,lacking
R11837 T14751 T14744 partOf site,Tat
R11838 T14751 T14750 themeOf site,binding
R11839 T14752 T14750 themeOf p65,binding
R11840 T14754 T14755 themeOf p65,binding
R11841 T14756 T14757 causeOf Tat,enhanced
R11842 T14758 T14759 themeOf p65,binding
R11843 T14759 T14757 themeOf binding,enhanced
R13884 T17262 T17266 causeOf Tat,promotes
R13885 T17262 T17265 causeOf Tat,promotes
R13886 T17262 T17264 themeOf Tat,occupies
R13887 T17267 T17268 themeOf p65,recruitment
R13888 T17267 T17270 themeOf p65,displacement
R13889 T17268 T17266 themeOf recruitment,promotes
R13890 T17269 T17270 themeOf IκB-α,displacement
R13891 T17270 T17265 themeOf displacement,promotes
R13892 T17275 T17280 causeOf Tat,increased
R13893 T17275 T17278 causeOf Tat,increased
R13894 T17275 T17277 causeOf Tat,increased
R13895 T17275 T17276 causeOf Tat,increased
R13896 T17275 T17279 causeOf Tat,increased
R13897 T17281 T17278 themeOf expression,increased
R13898 T17281 T17296 themeOf expression,ineffective
R13899 T17281 T17298 themeOf expression,ineffective
R13900 T17282 T17276 themeOf expression,increased
R13901 T17282 T17301 themeOf expression,ineffective
R13902 T17282 T17295 themeOf expression,ineffective
R13903 T17283 T17279 themeOf expression,increased
R13904 T17283 T17297 themeOf expression,ineffective
R13905 T17283 T17294 themeOf expression,ineffective
R13906 T17284 T17277 themeOf expression,increased
R13907 T17284 T17299 themeOf expression,ineffective
R13908 T17284 T17300 themeOf expression,ineffective
R13909 T17285 T17280 themeOf expression,increased
R13910 T17285 T17293 themeOf expression,ineffective
R13911 T17285 T17302 themeOf expression,ineffective
R13912 T17286 T17285 themeOf MIP-1α,expression
R13913 T17287 T17281 themeOf CSF3,expression
R13914 T17288 T17284 themeOf LTA,expression
R13915 T17289 T17282 themeOf NFKBIA,expression
R13916 T17290 T17283 themeOf TLR2,expression
R13917 T17291 T17293 causeOf "Tat C(22,25,27)A",ineffective
R13918 T17291 T17296 causeOf "Tat C(22,25,27)A",ineffective
R13919 T17291 T17299 causeOf "Tat C(22,25,27)A",ineffective
R13920 T17291 T17301 causeOf "Tat C(22,25,27)A",ineffective
R13921 T17291 T17297 causeOf "Tat C(22,25,27)A",ineffective
R13922 T17292 T17302 causeOf Tat R(49–57)A,ineffective
R13923 T17292 T17298 causeOf Tat R(49–57)A,ineffective
R13924 T17292 T17300 causeOf Tat R(49–57)A,ineffective
R13925 T17292 T17295 causeOf Tat R(49–57)A,ineffective
R13926 T17292 T17294 causeOf Tat R(49–57)A,ineffective
R13927 T17311 T17312 themeOf Tat,interaction
R13928 T17313 T17312 themeOf p65,interaction
R13929 T17315 T17316 themeOf MIP-1α,activated
R13930 T17317 T17316 causeOf Tat,activated
R13931 T17318 T17319 themeOf MIP-1α,expression
R13932 T17319 T17320 themeOf expression,increased
R13933 T17321 T17322 themeOf MIP-1α,production
R13934 T17322 T17323 themeOf production,induced
R13935 T17324 T17323 causeOf Tat,induced
R13936 T17325 T17326 themeOf transcriptional,regulation
R13937 T17327 T17325 themeOf MIP-1α,transcriptional
R13938 T17332 T17331 themeOf MIP-1α,expression
R13939 T17333 T17334 themeOf p65,occupancy
R13940 T17335 T17334 themeOf NF-κB sites,occupancy
R13941 T17335 T17332 partOf NF-κB sites,MIP-1α
R13942 T17336 T17337 causeOf TNF-α,activated
R13943 T17336 T17340 causeOf TNF-α,induced
R13944 T17336 T17345 causeOf TNF-α,affecting
R13945 T17338 T17337 themeOf expression,activated
R13946 T17339 T17338 themeOf MIP-1α,expression
R13947 T17341 T17342 themeOf p65,recruitment
R13948 T17341 T17346 themeOf p65,occupancy
R13949 T17342 T17340 themeOf recruitment,induced
R13950 T17343 T17342 themeOf NF-κB1 site,recruitment
R13951 T17343 T17344 partOf NF-κB1 site,MIP-1α
R13952 T17346 T17345 themeOf occupancy,affecting
R13953 T17347 T17348 causeOf Tat,promoted
R13954 T17349 T17348 themeOf recruitment,promoted
R13955 T17350 T17349 themeOf p65,recruitment
R13956 T17351 T17349 themeOf NF-κB1 site,recruitment
R13957 T17351 T17352 partOf NF-κB1 site,MIP-1α
R13958 T17357 T17373 causeOf Tat,ineffective
R13959 T17357 T17372 causeOf Tat,ineffective
R13960 T17357 T17358 causeOf Tat,increased
R13961 T17357 T17361 causeOf Tat,increased
R13962 T17357 T17359 causeOf Tat,increased
R13963 T17357 T17360 causeOf Tat,increased
R13964 T17362 T17359 themeOf recruitment,increased
R13965 T17363 T17358 themeOf recruitment,increased
R13966 T17364 T17360 themeOf recruitment,increased
R13967 T17365 T17361 themeOf recruitment,increased
R13968 T17366 T17364 themeOf p65,recruitment
R13969 T17366 T17363 themeOf p65,recruitment
R13970 T17366 T17365 themeOf p65,recruitment
R13971 T17366 T17362 themeOf p65,recruitment
R13972 T17367 T17364 themeOf NF-κB enhancers,recruitment
R13973 T17367 T17371 partOf NF-κB enhancers,TLR2
R13974 T17367 T17363 themeOf NF-κB enhancers,recruitment
R13975 T17367 T17368 partOf NF-κB enhancers,CSF3
R13976 T17367 T17365 themeOf NF-κB enhancers,recruitment
R13977 T17367 T17369 partOf NF-κB enhancers,LTA
R13978 T17367 T17362 themeOf NF-κB enhancers,recruitment
R13979 T17367 T17370 partOf NF-κB enhancers,NFKBIA
R13980 T17374 T17373 themeOf promoters,ineffective
R13981 T17374 T17375 partOf promoters,GAPDH
R13982 T17374 T17372 themeOf promoters,ineffective
R13983 T17374 T17376 partOf promoters,ACTB
R13984 T17377 T17378 themeOf Tat,bound
R13985 T17378 T17382 themeOf bound,loss
R13986 T17381 T17378 themeOf promoters,bound
R13987 T17381 T17379 partOf promoters,GAPDH
R13988 T17383 T17384 themeOf p65,interference
R13989 T17384 T17382 causeOf interference,loss
R13990 T17385 T17386 themeOf Tat,occupancy
R13991 T17385 T17389 themeOf Tat,interaction
R13992 T17386 T17387 themeOf occupancy,via
R13993 T17388 T17389 themeOf p65,interaction
R13994 T17389 T17387 causeOf interaction,via
R13995 T17390 T17391 themeOf IκB-α,chromatin-immunoprecipitated
R13996 T17391 T17393 themeOf chromatin-immunoprecipitated,removed
R13997 T17391 T17394 themeOf chromatin-immunoprecipitated,removed
R13998 T17395 T17393 causeOf Tat,removed
R13999 T17396 T17397 themeOf IκB-α,interference
R14000 T17397 T17394 causeOf interference,removed
R14001 T17398 T17399 causeOf Tat,displaced
R14002 T17400 T17401 themeOf IκB-α,from
R14003 T17401 T17399 themeOf from,displaced
R15286 T19087 T19093 themeOf Tat,interacting
R15287 T19088 T19092 themeOf promotes,by
R15288 T19089 T19090 themeOf transcriptional,activation
R15289 T19090 T19088 themeOf activation,promotes
R15290 T19091 T19089 themeOf MIP-1α,transcriptional
R15291 T19093 T19092 causeOf interacting,by
R15292 T19094 T19093 themeOf IκB-α,interacting
R15293 T19096 T19097 causeOf Tat,affected
R15294 T19098 T19097 themeOf expression,affected
R15295 T19099 T19098 themeOf MIP-1α,expression
R15296 T19105 T19106 themeOf Tat,expression
R15297 T19106 T19104 themeOf expression,modulate
R15298 T19107 T19111 themeOf expression,detected
R15299 T19108 T19112 themeOf expression,detected
R15300 T19109 T19108 themeOf Tat,expression
R15301 T19110 T19107 themeOf p24,expression
R15302 T19113 T19112 causeOf siRNA Tat,detected
R15303 T19113 T19111 causeOf siRNA Tat,detected
R15304 T19114 T19115 themeOf p65,binding
R15305 T19115 T19116 themeOf binding,induced
R15306 T19115 T19120 themeOf binding,increased
R15307 T19121 T19120 causeOf Tat,increased
R15308 T19122 T19124 causeOf Degradation,followed
R15309 T19123 T19122 themeOf IκB-α,Degradation
R15310 T19125 T19124 themeOf synthesis,followed
R15311 T19125 T19127 themeOf synthesis,independently
R15312 T19126 T19125 themeOf IκB-α,synthesis
R15313 T19128 T19127 causeOf Tat,independently
R15314 T19130 T19131 themeOf Tat,coimmunoprecipitated
R15315 T19130 T19134 causeOf Tat,activated
R15316 T19132 T19131 themeOf IκB-α,coimmunoprecipitated
R15317 T19134 T19138 causeOf activated,dependent
R15318 T19134 T19139 themeOf activated,lack
R15319 T19135 T19136 themeOf MIP-1α,expression
R15320 T19136 T19138 themeOf expression,dependent
R15321 T19137 T19134 themeOf p65,activated
R15322 T19139 T19140 themeOf lack,following
R15323 T19143 T19145 themeOf Tat,recruited
R15324 T19146 T19145 themeOf NF-κB enhancer,recruited
R15325 T19146 T19147 partOf NF-κB enhancer,MIP-1α
R15326 T19146 T19149 themeOf NF-κB enhancer,occupancy
R15327 T19148 T19149 themeOf p65,occupancy
R15328 T19149 T19150 themeOf occupancy,abolished
R15329 T19151 T19150 causeOf siRNA Tat,abolished
R15330 T19152 T19153 themeOf Tat,associated
R15331 T19152 T19161 themeOf Tat,occupancy
R15332 T19152 T19164 causeOf Tat,increased
R15333 T19154 T19153 themeOf IκB-α,associated
R15334 T19157 T19158 causeOf p65,activation
R15335 T19158 T19156 themeOf activation,induced
R15336 T19159 T19160 themeOf MIP-1α,expression
R15337 T19160 T19158 themeOf expression,activation
R15338 T19163 T19161 themeOf promoter,occupancy
R15339 T19163 T19162 partOf promoter,MIP-1α
R15340 T19163 T19165 themeOf promoter,recruitment
R15341 T19165 T19164 themeOf recruitment,increased
R15342 T19166 T19165 themeOf p65,recruitment
R18686 T23390 T23392 themeOf Tat,interacted
R18692 T23393 T23392 themeOf IκB-α,interacted
R18693 T23394 T23395 themeOf Tat,interaction
R18697 T23396 T23395 themeOf IκB-α,interaction
R18699 T23399 T23400 themeOf Tat,expression
R18701 T23400 T23398 themeOf expression,silence
R18702 T23401 T23402 themeOf IκB-α,degradation
R18704 T23404 T23403 themeOf Tat,absence
R18705 T23406 T23405 themeOf IκB-α,synthesis
R18707 T23409 T23408 themeOf Tat,silencing
R18708 T23410 T23411 causeOf Tat,affecting
R18709 T23412 T23411 themeOf IκB-α,affecting
R18711 T23416 T23415 themeOf IκB-α,synthesized
R18713 T23417 T23418 themeOf Tat,association
R18714 T23418 T23420 causeOf association,interfered
R18715 T23419 T23418 themeOf IκB-α,association
R18718 T23421 T23420 themeOf generation,interfered
R18719 T23422 T23421 themeOf IκB-α,generation
R18720 T23423 T23421 themeOf p65,generation
R18722 T23424 T23425 causeOf Tat,competed
R18723 T23424 T23429 causeOf Tat,prevented
R18724 T23426 T23425 themeOf binding,competed
R18725 T23427 T23426 themeOf IκB-α,binding
R18726 T23428 T23426 themeOf p65,binding
R18727 T23430 T23431 causeOf IκB-α,repression
R18728 T23431 T23429 themeOf repression,prevented
R18729 T23432 T23431 themeOf p65,repression
R18731 T23433 T23434 themeOf Tat,associated
R18732 T23433 T23436 causeOf Tat,increased
R18735 T23435 T23434 themeOf p65,associated
R18736 T23437 T23438 themeOf p65,binding
R18738 T23438 T23436 themeOf binding,increased
R18740 T23439 T23442 themeOf stronger,consequence
R18742 T23440 T23439 themeOf binding,stronger
R18743 T23441 T23440 themeOf p65,binding
R18744 T23441 T23443 themeOf p65,association
R18746 T23443 T23442 causeOf association,consequence
R18747 T23443 T23445 causeOf association,caused
R18749 T23444 T23443 themeOf Tat,association
R18750 T23446 T23445 themeOf change,caused
R18751 T23447 T23446 themeOf p65,change
R18753 T23448 T23451 themeOf Tat,binding
R18755 T23449 T23450 causeOf cysteine-rich sequence,involved
R18756 T23449 T23448 partOf cysteine-rich sequence,Tat
R18757 T23451 T23450 themeOf binding,involved
R18759 T23452 T23451 themeOf RHD,binding
R18760 T23452 T23453 partOf RHD,p65
R18762 T23454 T23458 themeOf Tat,binding
R18763 T23454 T23461 causeOf Tat,releasing
R18764 T23455 T23456 causeOf arginine-rich sequence,required
R18765 T23455 T23454 partOf arginine-rich sequence,Tat
R18766 T23455 T23457 causeOf arginine-rich sequence,required
R18768 T23458 T23456 themeOf binding,required
R18770 T23459 T23458 themeOf sixth ankyrin,binding
R18771 T23459 T23460 partOf sixth ankyrin,IκB-α
R18772 T23461 T23457 themeOf releasing,required
R18773 T23462 T23464 themeOf p65,inhibition
R18775 T23464 T23461 themeOf inhibition,releasing
R18777 T23465 T23466 themeOf Tat,hijacking
R18778 T23465 T23468 causeOf Tat,shielding
R18779 T23465 T23472 causeOf Tat,enforcing
R18780 T23467 T23466 themeOf IκB-α,hijacking
R18781 T23469 T23471 themeOf p65,embrace
R18782 T23470 T23471 themeOf IκB-α,embrace
R18783 T23471 T23468 themeOf embrace,shielding
R18785 T23473 T23474 themeOf p65,binding
R18786 T23474 T23472 themeOf binding,enforcing
R18790 T23483 T23484 causeOf Tat,increased
R18791 T23483 T23487 themeOf Tat,recovered
R18793 T23485 T23484 themeOf recruitment,increased
R18795 T23486 T23485 themeOf p65,recruitment
R18796 T23488 T23490 causeOf interference,abolished
R18797 T23489 T23488 themeOf p65,interference
R18799 T23491 T23492 themeOf Tat,occupancy
R18800 T23492 T23490 themeOf occupancy,abolished
R18801 T23493 T23494 themeOf Tat,binding
R18804 T23494 T23495 themeOf binding,mediated
R18805 T23592 T23591 themeOf Tat,assembly
R18806 T23496 T23495 causeOf p65,mediated
R18807 T23497 T23505 themeOf Tat,association
R18808 T23499 T23500 themeOf p65,binding
R18809 T23500 T23498 themeOf binding,displaced
R18810 T23501 T23500 themeOf IκB-α,binding
R18811 T23503 T23505 themeOf p65,association
R18812 T23503 T23504 themeOf p65,binding
R18813 T23504 T23502 themeOf binding,increased
R18814 T23593 T23591 themeOf p65,assembly
R18815 T23505 T23498 causeOf association,displaced
R18816 T23505 T23502 causeOf association,increased
R18817 T23506 T23513 causeOf Tat,interfering
R18818 T23506 T23511 themeOf Tat,associating
R18819 T23593 T23594 themeOf p65,displacement
R18820 T23595 T23594 themeOf IκB-α,displacement
R18821 T23509 T23507 themeOf recruitment,increased
R18822 T23509 T23508 themeOf recruitment,increased
R18823 T23510 T23509 themeOf p65,recruitment
R18824 T23598 T23599 themeOf Tat,interaction
R18825 T23511 T23508 causeOf associating,increased
R18826 T23512 T23511 themeOf p65,associating
R18827 T23513 T23507 causeOf interfering,increased
R18828 T23514 T23513 themeOf assembly,interfering
R18829 T23515 T23514 themeOf p65,assembly
R18830 T23516 T23514 themeOf IκB-α,assembly
R18831 T23598 T23600 themeOf Tat,interaction
R18832 T23517 T23519 themeOf IκB-α,associated
R18833 T23601 T23599 themeOf IκB-α,interaction
R18834 T23519 T23518 themeOf associated,found
R18835 T23520 T23518 causeOf absence,found
R18836 T23521 T23520 themeOf Tat,absence
R18837 T23602 T23600 themeOf p65,interaction
R18838 T23523 T23524 themeOf IκB-α,occupancy
R18839 T23604 T23603 themeOf counteract,inhibitors
R18840 T23525 T23526 themeOf IκB-α,associated
R18841 T23525 T23530 themeOf IκB-α,removed
R18842 T23605 T23604 themeOf Tat,counteract
R18843 T23529 T23527 themeOf promoter,at
R18844 T23529 T23528 partOf promoter,hes1
R18845 T23530 T23531 themeOf removed,following
R18846 T23530 T23533 causeOf removed,causing
R18848 T23532 T23531 causeOf TNF-α,following
R18849 T23534 T23535 themeOf hes1,transcriptional activation
R18850 T23535 T23533 themeOf transcriptional activation,causing
R18851 T23536 T23538 causeOf Tat,by
R18852 T23536 T23537 causeOf Tat,by
R18853 T23539 T23538 themeOf removing,by
R18854 T23540 T23539 themeOf IκB-α,removing
R18856 T23541 T23537 themeOf promoting,by
R18857 T23542 T23543 themeOf p65,loading
R18858 T23543 T23541 themeOf loading,promoting
R18859 T23544 T23545 themeOf Tat,cross talk
R18860 T23544 T23545 causeOf Tat,cross talk
R18864 T23550 T23549 themeOf Tat,coimmunoprecipitation
R18865 T23551 T23549 themeOf IκB-α,coimmunoprecipitation
R18867 T23553 T23556 themeOf induction,dependent
R18868 T23553 T23557 themeOf induction,dependent
R18869 T23554 T23555 themeOf MIP-1α,expression
R18871 T23555 T23553 themeOf expression,induction
R18873 T23558 T23556 causeOf Tat,dependent
R18874 T23559 T23557 causeOf p65,dependent
R18876 T23560 T23561 themeOf Tat,occupancy
R18878 T23563 T23561 themeOf NF-κB enhancer,occupancy
R18879 T23563 T23562 partOf NF-κB enhancer,MIP-1α
R18880 T23563 T23565 themeOf NF-κB enhancer,recruitment
R18882 T23565 T23564 themeOf recruitment,increased
R18883 T23566 T23565 themeOf p65,recruitment
R18885 T23567 T23568 themeOf Tat,interaction
R18886 T23569 T23568 themeOf p65,interaction
R18889 T23574 T23584 themeOf TNF-α,expression
R18890 T23574 T23588 themeOf TNF-α,transcriptional elongation
R18892 T23575 T23583 themeOf IL-6,expression
R18893 T23575 T23589 themeOf IL-6,transcriptional elongation
R18894 T23576 T23585 themeOf Tat,binding
R18897 T23583 T23580 themeOf expression,activated
R18898 T23583 T23577 themeOf expression,activated
R18899 T23583 T23581 themeOf expression,activated
R18900 T23584 T23582 themeOf expression,activated
R18901 T23584 T23578 themeOf expression,activated
R18902 T23584 T23579 themeOf expression,activated
R18903 T23585 T23582 causeOf binding,activated
R18904 T23585 T23587 causeOf binding,promoting
R18905 T23585 T23586 causeOf binding,promoting
R18906 T23585 T23580 causeOf binding,activated
R18907 T23586 T23579 causeOf promoting,activated
R18908 T23586 T23581 causeOf promoting,activated
R18909 T23587 T23578 causeOf promoting,activated
R18910 T23587 T23577 causeOf promoting,activated
R18912 T23588 T23587 themeOf transcriptional elongation,promoting
R18914 T23589 T23586 themeOf transcriptional elongation,promoting
R19331 T24285 T24286 themeOf Tat,expression
R19332 T24288 T24290 themeOf p65,binding
R19333 T24289 T24291 themeOf p50,binding
R19334 T24294 T24292 themeOf p65,expression
R19335 T24295 T24293 themeOf IκB-α,expression
R20000 T25060 T25061 themeOf Tat,associating
R20001 T25062 T25061 themeOf IκB-α,associating
R20002 T25064 T25068 themeOf p65,binding
R20003 T25065 T25067 themeOf p50,binding
R20004 T25066 T25069 themeOf FLAG-Tat,binding
R20896 T26333 T26334 causeOf Tat,relieves
R20897 T26335 T26337 themeOf p65,inhibition
R20898 T26336 T26337 causeOf IκB-α,inhibition
R20899 T26337 T26334 themeOf inhibition,relieves
R20900 T26352 T26353 themeOf p65,binding
R20901 T26354 T26359 themeOf p65,binding
R20902 T26355 T26358 causeOf HA-IκB-α,competition
R20903 T26359 T26358 themeOf binding,competition
R21302 T27104 T27105 themeOf Tat,associates
R21303 T27105 T27107 causeOf associates,increasing
R21304 T27106 T27105 themeOf p65,associates
R21305 T27106 T27108 themeOf p65,binding
R21306 T27108 T27107 themeOf binding,increasing
R22087 T28144 T28146 themeOf Tat,occupying
R22088 T28144 T28148 causeOf Tat,promoting
R22089 T28144 T28147 causeOf Tat,promoting
R22090 T28149 T28150 themeOf p65,recruitment
R22091 T28149 T28152 themeOf p65,displacement
R22092 T28150 T28148 themeOf recruitment,promoting
R22093 T28151 T28152 themeOf IκB-α,displacement
R22094 T28152 T28147 themeOf displacement,promoting
R22095 T28156 T28157 themeOf p65,interference
R22096 T28167 T28162 themeOf MIP-1α,expression
R22097 T28168 T28161 themeOf CSF3,expression
R22098 T28169 T28160 themeOf LTA,expression
R22099 T28170 T28163 themeOf NFKBIA,expression
R22100 T28171 T28165 themeOf TLR2,expression
R22101 T28172 T28164 themeOf GAPDH,expression
R22102 T28173 T28166 themeOf ACTB,expression
R22632 T28984 T28988 themeOf Tat,interaction
R22633 T28986 T28987 themeOf MIP-1α,expression
R22634 T28987 T28985 themeOf expression,enhances
R22635 T28988 T28985 causeOf interaction,enhances
R22636 T28989 T28988 themeOf IκB-α,interaction
R4882 T5628 T5627 equivalentTo TNF-α,tumor necrosis factor-α
R5176 T6018 T6016 themeOf p65,interference
R5177 T6019 T6017 themeOf IκB-α,interference
R5675 T6668 T6667 themeOf p65,Binding
R5676 T6669 T6666 themeOf p50,Binding
R5677 T6670 T6665 themeOf FLAG-Tat,Binding
R5816 T6850 T6853 themeOf HA-IκB-α,expressed
R5817 T6851 T6855 themeOf p65,expressed
R5818 T6852 T6854 themeOf Tat,expressed
R5819 T6853 T6856 themeOf expressed,under
R5820 T6854 T6858 themeOf expressed,under
R5821 T6855 T6857 themeOf expressed,under
R6264 T7469 T7470 themeOf GAPDH,levels
R22637 T28994 T28995 themeOf Tat,expression
R22638 T28998 T28997 themeOf p65,binding
R22639 T29005 T29006 themeOf MIP-1α,expression
R22929 T29372 T29373 themeOf MIP-1α,transcriptional
R22930 T29373 T29374 themeOf transcriptional,activation
R22931 T29375 T29374 causeOf Tat,activation
R22932 T29377 T29376 themeOf Tat,absence
R22933 T29378 T29379 themeOf IκB-α,occupies
R22934 T29378 T29382 themeOf IκB-α,interacts
R22935 T29380 T29379 themeOf NF-κB enhancer,occupies
R22936 T29380 T29381 partOf NF-κB enhancer,MIP-1α
R22937 T29383 T29384 causeOf Tat,activates
R22938 T29383 T29387 causeOf Tat,removing
R22939 T29383 T29389 causeOf Tat,increasing
R22940 T29385 T29386 themeOf MIP-1α,expression
R22941 T29386 T29384 themeOf expression,activates
R22942 T29388 T29387 themeOf IκB-α,removing
R22943 T29390 T29389 themeOf binding,increasing
R22944 T29391 T29390 themeOf NF-κB enhancer,binding
R22945 T29391 T29385 partOf NF-κB enhancer,MIP-1α

bionlp-st-ge-2016-reference-tees

Id Subject Object Predicate Lexical cue
T903 31-34 Protein denotes Tat
T904 45-50 Protein denotes NF-κB
T905 81-86 Protein denotes IκB-α
T906 35-44 Positive_regulation denotes activates
T907 64-75 Binding denotes interaction
T908 35-44 Positive_regulation denotes activates
T909 126-128 Protein denotes κB
T910 184-195 Positive_regulation denotes upregulated
T911 275-280 Protein denotes NF-κB
T912 281-293 Regulation denotes deregulation
T913 433-457 Protein denotes HIV-1 Tat transactivator
T914 468-473 Protein denotes NF-κB
T915 501-506 Protein denotes IκB-α
T916 554-567 Protein denotes NF-κB complex
T917 458-467 Positive_regulation denotes activated
T918 539-546 Binding denotes binding
T919 514-524 Negative_regulation denotes preventing
T920 579-582 Protein denotes Tat
T921 603-614 Protein denotes p65 subunit
T922 618-623 Protein denotes NF-κB
T923 642-645 Protein denotes p65
T924 583-593 Binding denotes associated
T925 740-743 Protein denotes Tat
T926 762-767 Protein denotes IκB-α
T927 772-775 Protein denotes p65
T928 826-831 Protein denotes NF-κB
T929 860-865 Protein denotes NF-κB
T930 884-887 Protein denotes Tat
T931 909-915 Protein denotes MIP-1α
T932 932-935 Protein denotes p65
T933 971-977 Protein denotes MIP-1α
T934 978-992 Protein denotes NF-κB enhancer
T935 1027-1030 Protein denotes p65
T936 1052-1057 Protein denotes IκB-α
T937 1098-1103 Protein denotes NF-κB
T938 1121-1125 Protein denotes CSF3
T939 1127-1130 Protein denotes LTA
T940 1132-1138 Protein denotes NFKBIA
T941 1143-1147 Protein denotes TLR2
T942 916-926 Gene_expression denotes expression
T943 958-963 Binding denotes bound
T944 1012-1023 Binding denotes recruitment
T945 895-904 Positive_regulation denotes activated
T946 1190-1195 Protein denotes NF-κB
T947 1235-1238 Protein denotes Tat
T948 1244-1249 Protein denotes IκB-α
T949 1254-1257 Protein denotes p65
T950 1196-1206 Positive_regulation denotes activation
T951 1220-1231 Binding denotes interaction
T4184 1393-1395 Protein denotes κB
T4185 1418-1426 Regulation denotes regulate
T4186 1521-1533 Protein denotes NF-κB family
T4187 1543-1547 Protein denotes RelA
T4188 1548-1551 Protein denotes p65
T4189 1553-1558 Protein denotes c-Rel
T4190 1560-1564 Protein denotes RelB
T4191 1566-1569 Protein denotes p50
T4192 1574-1577 Protein denotes p52
T4193 1735-1748 Protein denotes NF-κB complex
T4194 1867-1870 Protein denotes p65
T4195 1872-1876 Protein denotes RelB
T4196 1906-1911 Protein denotes NF-κB
T4197 1913-1916 Protein denotes IκB
T4198 1937-1942 Protein denotes NF-κB
T4199 1892-1902 Negative_regulation denotes Inhibitors
T4200 1892-1902 Negative_regulation denotes Inhibitors
T4201 1918-1927 Binding denotes associate
T4202 1974-1981 Binding denotes binding
T4203 1974-1981 Binding denotes binding
T4204 2022-2027 Protein denotes NF-κB
T4205 2054-2064 Protein denotes IκB kinase
T4206 2066-2069 Protein denotes IKK
T4207 2086-2089 Protein denotes IκB
T4208 2219-2224 Protein denotes NF-κB
T4209 2028-2038 Positive_regulation denotes activation
T4210 2044-2053 Positive_regulation denotes activated
T4211 2044-2053 Positive_regulation denotes activated
T4212 2071-2085 Phosphorylation denotes phosphorylates
T4213 2071-2085 Phosphorylation denotes phosphorylates
T4214 2071-2085 Phosphorylation denotes phosphorylates
T4215 2176-2187 Protein_catabolism denotes degradation
T4216 2176-2187 Protein_catabolism denotes degradation
T4217 2195-2203 Positive_regulation denotes releases
T4218 2195-2203 Positive_regulation denotes releases
T4219 2225-2232 Binding denotes complex
T4220 2123-2129 Regulation denotes target
T4221 2123-2129 Regulation denotes target
T4222 2249-2254 Protein denotes IκB-α
T4223 2287-2292 Protein denotes NF-κB
T4224 2319-2322 Protein denotes IKK
T4225 2274-2283 Negative_regulation denotes inhibitor
T4226 2274-2283 Negative_regulation denotes inhibitor
T4227 2336-2341 Entity denotes Ser36
T4228 2403-2411 Protein_catabolism denotes degraded
T4229 2301-2315 Phosphorylation denotes phosphorylated
T4230 2301-2315 Phosphorylation denotes phosphorylated
T4231 2443-2448 Protein denotes NF-κB
T4232 2492-2495 Protein denotes p65
T4233 2509-2512 Protein denotes PKA
T4234 2517-2521 Protein denotes MSK1
T4235 2461-2469 Positive_regulation denotes enhanced
T4236 2461-2469 Positive_regulation denotes enhanced
T4237 2473-2488 Phosphorylation denotes phosphorylation
T4238 2461-2469 Positive_regulation denotes enhanced
T4239 2591-2594 Protein denotes p65
T4240 2598-2604 Protein denotes Lys218
T4241 2609-2615 Protein denotes Lys221
T4242 2675-2680 Protein denotes IκB-α
T4243 2721-2724 Protein denotes p65
T4244 2576-2587 Negative_regulation denotes Acetylation
T4245 2576-2587 Negative_regulation denotes Acetylation
T4246 2576-2587 Negative_regulation denotes Acetylation
T4247 2658-2669 Binding denotes association
T4248 2708-2716 Positive_regulation denotes enhances
T4249 2787-2792 Protein denotes NF-κB
T4250 2888-2893 Protein denotes NF-κB
T4251 2903-2908 Protein denotes IκB-α
T4252 2913-2922 Protein denotes ubiquitin
T4253 2759-2774 Positive_regulation denotes Post-activation
T4254 2796-2805 Regulation denotes regulated
T4255 2877-2884 Regulation denotes control
T4256 2969-2972 Protein denotes p65
T4257 2976-2997 Protein denotes histone deacetylase-3
T4258 3001-3006 Protein denotes SIRT1
T4259 3026-3029 Protein denotes p65
T4260 3069-3074 Protein denotes NF-κB
T4261 3051-3064 Negative_regulation denotes down-regulate
T4262 3121-3126 Protein denotes NF-κB
T4263 3254-3259 Protein denotes NF-κB
T4264 3107-3117 Positive_regulation denotes activation
T4265 3240-3250 Gene_expression denotes expression
T4266 3227-3235 Positive_regulation denotes enhances
T4267 3709-3714 Protein denotes NF-κB
T4268 3825-3845 Protein denotes gp120 viral envelope
T4269 3849-3852 Protein denotes CD4
T4270 3865-3870 Protein denotes NF-κB
T4271 3810-3817 Binding denotes binding
T4272 3853-3860 Positive_regulation denotes induces
T4273 3962-3993 Protein denotes early encoded HIV-1 Tat protein
T4274 3994-4003 Binding denotes interacts
T4275 4079-4082 Protein denotes Tat
T4276 4231-4254 Protein denotes tumor necrosis factor β
T4277 4256-4260 Protein denotes TNFβ
T4278 4271-4284 Protein denotes interleukin-6
T4279 4286-4290 Protein denotes IL-6
T4280 4083-4088 Binding denotes binds
T4281 4083-4088 Binding denotes binds
T4282 4083-4088 Binding denotes binds
T4283 4083-4088 Binding denotes binds
T4284 4083-4088 Binding denotes binds
T4285 4083-4088 Binding denotes binds
T4286 4083-4088 Binding denotes binds
T4287 4337-4340 Protein denotes Tat
T4288 4459-4474 Protein denotes Sp1 (35), TFIID
T4289 4481-4486 Protein denotes E2F-4
T4290 4493-4499 Protein denotes C/EBPβ
T4291 4506-4520 Protein denotes cyclin T1/CDK9
T4292 4537-4563 Protein denotes histone acetyltransferases
T4293 4564-4568 Protein denotes p300
T4294 4569-4572 Protein denotes CBP
T4295 4399-4410 Binding denotes interacting
T4296 4399-4410 Binding denotes interacting
T4297 4399-4410 Binding denotes interacting
T4298 4399-4410 Binding denotes interacting
T4299 4399-4410 Binding denotes interacting
T4300 4399-4410 Binding denotes interacting
T4301 4399-4410 Binding denotes interacting
T4302 4399-4410 Binding denotes interacting
T4303 4399-4410 Binding denotes interacting
T4304 4399-4410 Binding denotes interacting
T4305 4399-4410 Binding denotes interacting
T4306 4399-4410 Binding denotes interacting
T4307 4399-4410 Binding denotes interacting
T4308 4399-4410 Binding denotes interacting
T4309 4399-4410 Binding denotes interacting
T4310 4399-4410 Binding denotes interacting
T4311 4399-4410 Binding denotes interacting
T4312 4399-4410 Binding denotes interacting
T4313 4399-4410 Binding denotes interacting
T4314 4399-4410 Binding denotes interacting
T4315 4399-4410 Binding denotes interacting
T4316 4633-4636 Protein denotes Tat
T4317 4722-4726 Protein denotes Flk1
T4318 4727-4730 Protein denotes KDR
T4319 4671-4678 Binding denotes binding
T4320 4671-4678 Binding denotes binding
T4321 4671-4678 Binding denotes binding
T4322 4798-4803 Protein denotes NF-κB
T4323 4872-4875 Protein denotes Tat
T4324 4858-4867 Gene_expression denotes expressed
T4325 4940-4943 Protein denotes Tat
T4326 4956-4959 Protein denotes IKK
T4327 5000-5005 Protein denotes IκB-α
T4328 5030-5033 Protein denotes p65
T4329 5077-5083 Protein denotes SIRT-1
T4330 5110-5120 Protein denotes p65 Lys310
T4331 4944-4951 Positive_regulation denotes induced
T4332 4985-4996 Protein_catabolism denotes degradation
T4333 4985-4996 Protein_catabolism denotes degradation
T4334 5016-5025 Positive_regulation denotes increased
T4335 4944-4951 Positive_regulation denotes induced
T4336 4944-4951 Positive_regulation denotes induced
T4337 5199-5204 Protein denotes NF-κB
T4338 5244-5247 Protein denotes Tat
T4339 5287-5292 Protein denotes NF-κB
T4340 5344-5349 Protein denotes IκB-α
T4341 5331-5340 Gene_expression denotes synthesis
T4342 5384-5389 Protein denotes IκB-α
T4343 5399-5402 Protein denotes Tat
T4344 5390-5395 Binding denotes binds
T4345 5502-5505 Protein denotes Tat
T4346 5550-5555 Protein denotes NF-κB
T4347 5588-5593 Protein denotes IκB-α
T4348 5598-5601 Protein denotes p65
T4349 5670-5683 Protein denotes NF-κB complex
T4350 5506-5517 Binding denotes counteracts
T4351 5571-5582 Binding denotes interaction
T4352 5571-5582 Binding denotes interaction
T4353 5626-5633 Binding denotes binding
T4354 5609-5617 Positive_regulation denotes enhances
T4355 5609-5617 Positive_regulation denotes enhances
T4356 5706-5711 Protein denotes NF-κB
T4357 5712-5724 Regulation denotes deregulation
T4857 5861-5886 Protein denotes plasmids pcDNA-3xHA-IκB-α
T4858 6115-6120 Protein denotes pHXB2
T4859 6121-6124 Protein denotes env
T4860 6226-6232 Protein denotes pκBluc
T5636 6598-6608 Protein denotes luciferase
T5637 7077-7086 Protein denotes FuGENE HD
T5638 7428-7451 Protein denotes tumor necrosis factor-α
T5639 7453-7458 Protein denotes TNF-α
T5640 7460-7473 Protein denotes Sigma-Aldrich
T5641 7572-7582 Protein denotes luciferase
T5642 7625-7631 Protein denotes pκBluc
T5643 7605-7619 Gene_expression denotes co-transfected
T5644 7605-7619 Gene_expression denotes co-transfected
T5645 7605-7619 Positive_regulation denotes co-transfected
T5646 7605-7619 Positive_regulation denotes co-transfected
T5647 7749-7765 Protein denotes Light Luciferase
T5648 7808-7818 Protein denotes luciferase
T5649 7823-7838 Protein denotes β-galactosidase
T5650 7879-7895 Protein denotes Light Luciferase
T5651 7993-8003 Protein denotes luciferase
T5652 8016-8031 Protein denotes β-galactosidase
T6268 9126-9129 Protein denotes p24
T6269 9227-9235 Protein denotes HXB2 Env
T6270 9267-9270 Protein denotes p24
T6671 9354-9357 Protein denotes IKK
T6672 9371-9380 Protein denotes NF-κB DNA
T6673 9381-9388 Binding denotes binding
T6674 9881-9892 Protein denotes horseradish
T6675 9893-9903 Protein denotes peroxidase
T6676 10260-10269 Protein denotes IκB-α C15
T6677 10271-10286 Protein denotes anti-Histone H1
T6678 10324-10336 Protein denotes anti-FLAG M2
T6679 10338-10352 Protein denotes anti-γ-Tubulin
T6680 10478-10481 Protein denotes IKK
T6681 10537-10547 Protein denotes HTScan IKK
T6682 10623-10626 Protein denotes p65
T6683 10628-10631 Protein denotes p50
T6684 10636-10640 Protein denotes FLAG
T6685 10641-10644 Protein denotes Tat
T6686 10668-10673 Protein denotes NF-κB
T6687 10709-10714 Protein denotes NF-κB
T6688 10674-10689 Entity denotes oligonucleotide
T6689 10612-10619 Binding denotes Binding
T6690 10612-10619 Binding denotes Binding
T6691 10612-10619 Binding denotes Binding
T6692 10612-10619 Binding denotes Binding
T6859 10954-10956 Protein denotes HA
T6860 10957-10962 Protein denotes IκB-α
T6861 10964-10967 Protein denotes p65
T6862 10972-10975 Protein denotes Tat
T6863 11001-11012 Protein denotes T7 promoter
T6864 11047-11050 Protein denotes TnT
T6865 10981-10990 Gene_expression denotes expressed
T6866 10981-10990 Gene_expression denotes expressed
T6867 10981-10990 Gene_expression denotes expressed
T6868 10981-10990 Gene_expression denotes expressed
T6869 10981-10990 Gene_expression denotes expressed
T6974 11214-11217 Protein denotes GST
T6975 11249-11252 Protein denotes GST
T6976 11282-11285 Protein denotes GST
T7472 11588-11625 Protein denotes Superscript III Reverse Transcriptase
T7473 11934-11937 Protein denotes Tat
T7474 11942-11948 Protein denotes MIP-1α
T7475 12000-12004 Protein denotes CSF3
T7476 12006-12009 Protein denotes LTA
T7477 12011-12017 Protein denotes NFKBIA
T7478 12019-12023 Protein denotes TLR2
T7479 12025-12030 Protein denotes GAPDH
T7480 12035-12039 Protein denotes ACTB
T7481 12064-12080 Protein denotes RT2 profiler PCR
T7482 12093-12098 Protein denotes NF-κB
T7483 12242-12252 Protein denotes GAPDH mRNA
T7484 12196-12206 Gene_expression denotes expression
T7485 12353-12361 Protein denotes Ct GAPDH
T7486 12292-12302 Gene_expression denotes expression
T8137 12365-12374 Protein denotes Chromatin
T8138 12751-12771 Protein denotes 1× Complete Protease
T8139 12772-12781 Negative_regulation denotes Inhibitor
T8140 12930-12939 Protein denotes Chromatin
T8141 13376-13379 Protein denotes p65
T8142 13390-13408 Protein denotes anti-IκBα (sc-203)
T8143 13420-13423 Protein denotes IgG
T8144 14148-14162 Protein denotes NF-κB enhancer
T8145 14257-14280 Protein denotes SYBR GreenER Master Mix
T8146 14484-14490 Protein denotes MIP-1α
T8147 14492-14497 Protein denotes GAPDH
T8148 14502-14506 Protein denotes ACTB
T8149 14558-14562 Protein denotes CSF3
T8150 14564-14567 Protein denotes LTA
T8151 14569-14575 Protein denotes NFKBIA
T8152 14580-14584 Protein denotes TLR2
T8153 14734-14737 Protein denotes IgG
T11177 14991-14994 Protein denotes Tat
T11178 15008-15013 Protein denotes NF-κB
T11179 15036-15041 Protein denotes IκB-α
T11180 15089-15094 Protein denotes NF-κB
T11181 14995-15003 Positive_regulation denotes enhances
T11182 15026-15035 Positive_regulation denotes hijacking
T11183 15122-15127 Protein denotes NF-κB
T11184 15203-15206 Protein denotes Tat
T11185 15128-15138 Positive_regulation denotes activation
T11186 15189-15199 Gene_expression denotes expression
T11187 15174-15184 Regulation denotes modulating
T11188 15265-15281 Protein denotes siRNA Tat, siRNA
T11189 15354-15362 Protein denotes HXB2 Env
T11190 15552-15555 Protein denotes Tat
T11191 15722-15725 Protein denotes Tat
T11192 15538-15548 Gene_expression denotes expression
T11193 15609-15618 Positive_regulation denotes increased
T11194 15726-15737 Gene_expression denotes transfected
T11195 15726-15737 Positive_regulation denotes transfected
T11196 15775-15785 Protein denotes luciferase
T11197 15949-15952 Protein denotes Tat
T11198 15992-15995 Protein denotes Tat
T11199 15786-15796 Gene_expression denotes expression
T11200 15820-15827 Positive_regulation denotes induced
T11201 15953-15964 Gene_expression denotes transfected
T11202 15953-15964 Positive_regulation denotes transfected
T11203 17273-17278 Protein denotes NF-κB
T11204 17304-17307 Protein denotes p65
T11205 17308-17311 Protein denotes p50
T11206 17457-17460 Protein denotes Tat
T11207 17571-17578 Protein denotes p65 DNA
T11208 17637-17640 Protein denotes Tat
T11209 17261-17269 Positive_regulation denotes increase
T11210 17312-17319 Binding denotes binding
T11211 17312-17319 Binding denotes binding
T11212 17434-17448 Localization denotes post-infection
T11213 17461-17469 Gene_expression denotes positive
T11214 17579-17586 Binding denotes binding
T11215 17613-17621 Positive_regulation denotes elevated
T11216 17625-17633 Localization denotes presence
T11217 17613-17621 Positive_regulation denotes elevated
T11218 17739-17744 Protein denotes IκB-α
T11219 17885-17888 Protein denotes Tat
T11220 17902-17905 Protein denotes Tat
T11221 17749-17757 Protein_catabolism denotes degraded
T11222 17889-17897 Gene_expression denotes positive
T11223 17906-17914 Gene_expression denotes negative
T11224 17906-17914 Gene_expression denotes negative
T11225 17961-17964 Protein denotes IKK
T11226 17978-17985 Positive_regulation denotes induced
T11227 18013-18022 Negative_regulation denotes decreased
T11228 18115-18120 Protein denotes NF-κB
T11229 18131-18134 Protein denotes IKK
T11230 18150-18155 Protein denotes IκB-α
T11231 18301-18322 Protein denotes reverse transcriptase
T11232 18135-18145 Positive_regulation denotes activation
T11233 18156-18180 Gene_expression denotes degradation/re-synthesis
T11234 18156-18180 Gene_expression denotes degradation/re-synthesis
T11235 18135-18145 Positive_regulation denotes activation
T11236 18135-18145 Positive_regulation denotes activation
T11237 18426-18431 Protein denotes NF-κB
T11238 18473-18476 Protein denotes IKK
T11239 18492-18497 Protein denotes IκB-α
T11240 18543-18546 Protein denotes Tat
T11241 18588-18591 Protein denotes Tat
T11242 18619-18622 Protein denotes IKK
T11243 18653-18658 Protein denotes IκB-α
T11244 18432-18442 Positive_regulation denotes activation
T11245 18477-18487 Positive_regulation denotes activation
T11246 18498-18509 Protein_catabolism denotes degradation
T11247 18640-18649 Gene_expression denotes synthesis
T11248 18477-18487 Positive_regulation denotes activation
T11249 18564-18572 Positive_regulation denotes elevated
T11250 18697-18700 Protein denotes Tat
T11251 18719-18724 Protein denotes NF-κB
T11252 18734-18741 Positive_regulation denotes induced
T11253 18796-18799 Protein denotes p3x
T11254 18800-18804 Protein denotes FLAG
T11255 18805-18808 Protein denotes Tat
T11256 18917-18922 Protein denotes NF-κB
T11257 18923-18933 Positive_regulation denotes activation
T11258 18971-18978 Protein denotes p65 DNA
T11259 19062-19065 Protein denotes Tat
T11260 19077-19082 Protein denotes IκB-α
T11261 18979-18986 Binding denotes binding
T11262 19050-19058 Positive_regulation denotes enhanced
T11263 19113-19121 Regulation denotes affected
T11264 19189-19194 Protein denotes NF-κB
T11265 19220-19240 Protein denotes nuclear p65 at 5 min
T11266 19338-19345 Protein denotes p65 DNA
T11267 19454-19457 Protein denotes Tat
T11268 19458-19466 Gene_expression denotes negative
T11269 19505-19508 Protein denotes Tat
T11270 19522-19543 Protein denotes NF-κB oligonucleotide
T11271 19689-19702 Protein denotes NF-κB complex
T11272 19509-19514 Binding denotes bound
T11273 19509-19514 Binding denotes bound
T11274 19575-19582 Binding denotes binding
T11275 19583-19592 Positive_regulation denotes increased
T11276 19672-19681 Gene_expression denotes component
T11277 19703-19708 Binding denotes bound
T11278 19732-19737 Protein denotes IκB-α
T11279 19860-19863 Protein denotes Tat
T11280 19717-19728 Protein_catabolism denotes Degradation
T11281 19756-19763 Positive_regulation denotes induced
T11282 19864-19872 Gene_expression denotes positive
T11283 19932-19935 Protein denotes IKK
T11284 19936-19946 Positive_regulation denotes activation
T11285 20069-20072 Protein denotes Tat
T11286 20086-20091 Protein denotes NF-κB
T11287 20165-20168 Protein denotes IKK
T11288 20182-20187 Protein denotes IκB-α
T11289 20073-20081 Positive_regulation denotes enhanced
T11290 20151-20160 Regulation denotes affecting
T11291 20151-20160 Regulation denotes affecting
T11292 21841-21844 Protein denotes Tat
T11293 21864-21871 Protein denotes ankyrin
T11294 21875-21880 Protein denotes IκB-α
T11295 21908-21911 Protein denotes Tat
T11296 21947-21952 Protein denotes IκB-α
T11297 21953-21966 Protein denotes NF-κB complex
T11298 21845-21850 Binding denotes binds
T11299 21845-21850 Binding denotes binds
T11300 21912-21924 Binding denotes counteracted
T11301 21912-21924 Binding denotes counteracted
T11302 21929-21939 Positive_regulation denotes generation
T11303 21929-21939 Positive_regulation denotes generation
T11304 22000-22005 Protein denotes IκB-α
T11305 22011-22014 Protein denotes p65
T11306 22175-22180 Protein denotes IκB-α
T11307 21985-21996 Binding denotes association
T11308 22162-22171 Gene_expression denotes synthesis
T11309 22221-22226 Protein denotes IκB-α
T11310 22232-22235 Protein denotes p65
T11311 22285-22288 Protein denotes Tat
T11312 22350-22353 Protein denotes Tat
T11313 22376-22379 Protein denotes Tat
T11314 22406-22411 Protein denotes IκB-α
T11315 22456-22459 Protein denotes Tat
T11316 22473-22478 Protein denotes IκB-α
T11317 22490-22493 Protein denotes p65
T11318 22196-22217 Binding denotes Coimmunoprecipitation
T11319 22289-22297 Gene_expression denotes negative
T11320 22354-22362 Gene_expression denotes positive
T11321 22380-22400 Binding denotes coimmunoprecipitated
T11322 22380-22400 Binding denotes coimmunoprecipitated
T11323 22460-22468 Binding denotes competed
T11324 22479-22486 Binding denotes binding
T13000 22496-22499 Protein denotes Tat
T13001 22516-22521 Protein denotes IκB-α
T13002 22536-22539 Protein denotes p65
T13003 22500-22511 Binding denotes counteracts
T13004 22522-22532 Negative_regulation denotes inhibition
T13005 22522-22532 Negative_regulation denotes inhibition
T13006 22627-22630 Protein denotes Tat
T13007 22636-22641 Protein denotes IκB-α
T13008 22612-22623 Binding denotes interaction
T13009 22769-22780 Protein denotes Tat mutants
T13010 22862-22867 Protein denotes IκB-α
T13011 22898-22910 Protein denotes Tat proteins
T13012 22919-22922 Protein denotes Tat
T13013 23003-23006 Protein denotes Tat
T13014 23038-23043 Protein denotes IκB-α
T13015 23027-23034 Binding denotes binding
T13016 23112-23115 Protein denotes Tat
T13017 23133-23138 Protein denotes IκB-α
T13018 23163-23168 Protein denotes IκB-α
T13019 23172-23175 Protein denotes p65
T13020 23233-23238 Protein denotes Tat R
T13021 23282-23287 Protein denotes IκB-α
T13022 23312-23317 Protein denotes IκB-α
T13023 23353-23358 Protein denotes IκB-α
T13024 23116-23127 Binding denotes associating
T13025 23152-23159 Binding denotes binding
T13026 23265-23272 Binding denotes binding
T13027 23297-23306 Binding denotes associate
T13028 23297-23306 Binding denotes associate
T13029 23342-23349 Binding denotes binding
T13030 23139-23147 Negative_regulation denotes competed
T13031 23254-23260 Negative_regulation denotes lacked
T13032 23330-23337 Negative_regulation denotes compete
T13033 25511-25514 Protein denotes Tat
T13034 25532-25537 Protein denotes IκB-α
T13035 25561-25564 Protein denotes p65
T13036 25614-25617 Protein denotes p65
T13037 25622-25636 Protein denotes IκB-α proteins
T13038 25646-25651 Protein denotes NF-κB
T13039 25684-25687 Protein denotes Tat
T13040 25515-25527 Binding denotes counteracted
T13041 25565-25572 Binding denotes binding
T13042 25547-25557 Negative_regulation denotes inhibition
T13043 25710-25717 Protein denotes p65 DNA
T13044 25752-25757 Protein denotes IκB-α
T13045 25827-25832 Protein denotes Tat R
T13046 25718-25725 Binding denotes binding
T13047 25739-25748 Negative_regulation denotes inhibited
T13048 25762-25770 Positive_regulation denotes restored
T13049 25762-25770 Positive_regulation denotes restored
T13050 25878-25881 Protein denotes Tat
T13051 25896-25901 Protein denotes IκB-α
T13052 25916-25919 Protein denotes p65
T13053 25987-25992 Protein denotes NF-κB
T13054 25993-25996 Protein denotes Luc
T13055 26042-26045 Protein denotes p65
T13056 26050-26055 Protein denotes IκB-α
T13057 26083-26086 Protein denotes Tat
T13058 25902-25912 Negative_regulation denotes repression
T13059 26020-26030 Gene_expression denotes expression
T13060 26020-26030 Gene_expression denotes expression
T13061 25882-25888 Regulation denotes effect
T13062 26088-26093 Protein denotes IκB-α
T13063 26108-26111 Protein denotes p65
T13064 26140-26155 Protein denotes luciferase gene
T13065 26232-26237 Protein denotes Tat R
T13066 26122-26132 Gene_expression denotes expression
T13067 26094-26103 Negative_regulation denotes inhibited
T13068 26112-26121 Positive_regulation denotes dependent
T13069 26299-26302 Protein denotes Tat
T13070 26319-26324 Protein denotes IκB-α
T13071 26343-26350 Protein denotes p65 DNA
T13072 26408-26413 Protein denotes IκB-α
T13073 26453-26456 Protein denotes p65
T13074 26303-26314 Binding denotes counteracts
T13075 26325-26335 Negative_regulation denotes repression
T13076 26351-26358 Binding denotes binding
T13077 26391-26402 Binding denotes associating
T13078 26442-26449 Binding denotes binding
T13079 26325-26335 Negative_regulation denotes repression
T14760 26459-26462 Protein denotes Tat
T14761 26477-26480 Protein denotes p65
T14762 26490-26497 Binding denotes binding
T14763 26463-26472 Positive_regulation denotes increases
T14764 26552-26555 Protein denotes Tat
T14765 26583-26586 Protein denotes p65
T14766 26567-26577 Binding denotes interacted
T14767 26647-26649 Protein denotes HA
T14768 26650-26653 Protein denotes p65
T14769 26658-26662 Protein denotes FLAG
T14770 26663-26666 Protein denotes Tat
T14771 26683-26686 Protein denotes Tat
T14772 26625-26635 Gene_expression denotes expression
T14773 26625-26635 Gene_expression denotes expression
T14774 26625-26635 Gene_expression denotes expression
T14775 26625-26635 Gene_expression denotes expression
T14776 26734-26745 Protein denotes p65 protein
T14777 26776-26789 Protein denotes wild-type Tat
T14778 26797-26810 Protein denotes mutants Tat T
T14779 26944-26949 Protein denotes Tat C
T14780 26750-26770 Binding denotes coimmunoprecipitated
T14781 26750-26770 Binding denotes coimmunoprecipitated
T14782 26893-26901 Negative_regulation denotes decrease
T14783 26893-26901 Negative_regulation denotes decrease
T14784 26988-26991 Protein denotes GST
T14785 27063-27066 Protein denotes p65
T14786 27092-27105 Protein denotes mutants Tat T
T14787 27173-27178 Protein denotes Tat C
T14788 27052-27059 Binding denotes binding
T14789 27052-27059 Binding denotes binding
T14790 27162-27169 Binding denotes binding
T14791 27162-27169 Binding denotes binding
T14792 27162-27169 Binding denotes binding
T14793 27232-27235 Protein denotes Tat
T14794 27252-27255 Protein denotes p65
T14795 27236-27246 Binding denotes associated
T14796 27356-27367 Binding denotes interaction
T14797 29109-29119 Protein denotes p65 domain
T14798 29144-29147 Protein denotes Tat
T14799 29205-29219 Protein denotes HA-p65 mutants
T14800 29133-29140 Binding denotes binding
T14801 29120-29128 Positive_regulation denotes required
T14802 29443-29446 Protein denotes p65
T14803 29493-29496 Protein denotes Tat
T14804 29476-29487 Binding denotes interaction
T14805 29523-29526 Protein denotes Tat
T14806 29534-29537 Protein denotes p65
T14807 29569-29592 Protein denotes recombinant p65 protein
T14808 29627-29629 Protein denotes κB
T14809 29705-29710 Protein denotes Tat C
T14810 29727-29730 Protein denotes p65
T14811 29826-29829 Protein denotes p65
T14812 29896-29899 Protein denotes p65
T14813 29815-29822 Binding denotes binding
T14814 29879-29886 Binding denotes binding
T14815 29801-29810 Positive_regulation denotes increased
T14816 29934-29937 Protein denotes p65
T14817 30009-30030 Protein denotes cold competitor NF-κB
T14818 30066-30069 Protein denotes Tat
T14819 30097-30100 Protein denotes p65
T14820 29938-29945 Binding denotes binding
T14821 30110-30117 Binding denotes binding
T14822 30084-30092 Positive_regulation denotes enhanced
T17402 30145-30148 Protein denotes Tat
T17403 30163-30166 Protein denotes p65
T17404 30191-30196 Protein denotes NF-κB
T17405 30228-30243 Protein denotes NF-κB enhancers
T17406 30261-30264 Protein denotes p65
T17407 30282-30300 Protein denotes IκB-α displacement
T17408 30265-30276 Binding denotes recruitment
T17409 30248-30256 Positive_regulation denotes promotes
T17410 30327-30330 Protein denotes Tat
T17411 30352-30357 Protein denotes NF-κB
T17412 30430-30438 Protein denotes FLAG-Tat
T17413 30440-30444 Protein denotes FLAG
T17414 30445-30448 Protein denotes Tat
T17415 30530-30535 Protein denotes NF-κB
T17416 30583-30586 Protein denotes Tat
T17417 30629-30635 Protein denotes MIP-1α
T17418 30637-30641 Protein denotes CSF3
T17419 30643-30646 Protein denotes LTA
T17420 30648-30654 Protein denotes NFKBIA
T17421 30659-30663 Protein denotes TLR2
T17422 30615-30625 Gene_expression denotes expression
T17423 30615-30625 Gene_expression denotes expression
T17424 30615-30625 Gene_expression denotes expression
T17425 30615-30625 Gene_expression denotes expression
T17426 30615-30625 Gene_expression denotes expression
T17427 30601-30610 Positive_regulation denotes increased
T17428 30601-30610 Positive_regulation denotes increased
T17429 30601-30610 Positive_regulation denotes increased
T17430 30601-30610 Positive_regulation denotes increased
T17431 30601-30610 Positive_regulation denotes increased
T17432 30754-30757 Protein denotes Tat
T17433 30791-30796 Protein denotes NF-κB
T17434 30860-30869 Protein denotes siRNA p65
T17435 30891-30894 Protein denotes Tat
T17436 30911-30921 Positive_regulation denotes activation
T17437 30992-30997 Protein denotes NF-κB
T17438 31016-31021 Protein denotes GAPDH
T17439 31026-31030 Protein denotes ACTB
T17440 31063-31074 Protein denotes Tat mutants
T17441 30974-30984 Gene_expression denotes expression
T17442 30974-30984 Gene_expression denotes expression
T17443 30974-30984 Gene_expression denotes expression
T17444 31035-31045 Regulation denotes unaffected
T17445 31035-31045 Regulation denotes unaffected
T17446 31035-31045 Regulation denotes unaffected
T17447 31200-31203 Protein denotes Tat
T17448 31219-31224 Protein denotes NF-κB
T17449 31272-31277 Protein denotes NF-κB
T17450 31298-31301 Protein denotes Tat
T17451 31369-31372 Protein denotes p65
T17452 31377-31382 Protein denotes IκB-α
T17453 31207-31214 Positive_regulation denotes enhance
T17454 31331-31342 Binding denotes interaction
T17455 31331-31342 Binding denotes interaction
T17456 32978-32984 Protein denotes MIP-1α
T17457 33025-33028 Protein denotes Tat
T17458 33148-33154 Protein denotes MIP-1α
T17459 33247-33253 Protein denotes MIP-1α
T17460 33308-33311 Protein denotes Tat
T17461 33155-33165 Gene_expression denotes expression
T17462 33170-33179 Positive_regulation denotes increased
T17463 33254-33264 Gene_expression denotes production
T17464 33269-33276 Positive_regulation denotes induced
T17465 33366-33372 Protein denotes MIP-1α
T17466 33352-33362 Regulation denotes regulation
T17467 33480-33495 Protein denotes NF-κB enhancers
T17468 33535-33546 Protein denotes MIP-1α gene
T17469 33548-33554 Protein denotes NF-κB1
T17470 33581-33587 Protein denotes NF-κB2
T17471 33612-33618 Protein denotes NF-κB3
T17472 33455-33464 Gene_expression denotes predicted
T17473 33455-33464 Gene_expression denotes predicted
T17474 33521-33527 Positive_regulation denotes region
T17475 33696-33701 Protein denotes NF-κB
T17476 33723-33738 Protein denotes MIP-1α promoter
T17477 33770-33775 Protein denotes TNF-α
T17478 33790-33795 Protein denotes NF-κB
T17479 33843-33849 Protein denotes MIP-1α
T17480 33876-33879 Protein denotes p65
T17481 33897-33908 Protein denotes NF-κB sites
T17482 33796-33803 Positive_regulation denotes inducer
T17483 33822-33832 Gene_expression denotes expression
T17484 33880-33889 Positive_regulation denotes occupancy
T17485 33880-33889 Positive_regulation denotes occupancy
T17486 33918-33923 Protein denotes TNF-α
T17487 33952-33958 Protein denotes MIP-1α
T17488 33975-33990 Protein denotes p65 recruitment
T17489 33998-34009 Protein denotes NF-κB1 site
T17490 34013-34019 Protein denotes MIP-1α
T17491 34068-34074 Protein denotes NF-κB2
T17492 34122-34125 Protein denotes S3C
T17493 33938-33948 Gene_expression denotes expression
T17494 33963-33970 Positive_regulation denotes induced
T17495 34042-34051 Gene_expression denotes occupancy
T17496 34042-34051 Gene_expression denotes occupancy
T17497 33924-33933 Positive_regulation denotes activated
T17498 34028-34037 Regulation denotes affecting
T17499 34028-34037 Regulation denotes affecting
T17500 34128-34131 Protein denotes Tat
T17501 34165-34168 Protein denotes p65
T17502 34176-34187 Protein denotes NF-κB1 site
T17503 34191-34197 Protein denotes MIP-1α
T17504 34236-34242 Protein denotes NF-κB2
T17505 34332-34343 Protein denotes NF-κB1 site
T17506 34367-34381 Protein denotes NF-κB enhancer
T17507 34389-34404 Protein denotes MIP-1α promoter
T17508 34420-34425 Protein denotes TNF-α
T17509 34430-34433 Protein denotes Tat
T17510 34357-34366 Positive_regulation denotes effective
T17511 34448-34454 Protein denotes MIP-1α
T17512 34456-34459 Protein denotes Tat
T17513 34489-34492 Protein denotes p65
T17514 34500-34505 Protein denotes NF-κB
T17515 34519-34523 Protein denotes CSF3
T17516 34525-34528 Protein denotes LTA
T17517 34530-34536 Protein denotes NFKBIA
T17518 34541-34545 Protein denotes TLR2
T17519 34592-34597 Protein denotes GAPDH
T17520 34602-34606 Protein denotes ACTB
T17521 34506-34515 Entity denotes enhancers
T17522 34474-34485 Binding denotes recruitment
T17523 34460-34469 Positive_regulation denotes increased
T17524 34623-34627 Protein denotes ChIP
T17525 34629-34632 Protein denotes Tat
T17526 34646-34651 Protein denotes NF-κB
T17527 34689-34694 Protein denotes GAPDH
T17528 34699-34713 Protein denotes ACTB promoters
T17529 34736-34753 Protein denotes following p65 RNA
T17530 34796-34799 Protein denotes Tat
T17531 34823-34826 Protein denotes p65
T17532 34728-34735 Binding denotes binding
T17533 34827-34838 Binding denotes interaction
T17534 34720-34724 Negative_regulation denotes loss
T17535 34864-34869 Protein denotes IκB-α
T17536 34910-34925 Protein denotes NF-κB enhancers
T17537 34940-34943 Protein denotes Tat
T17538 34993-34996 Protein denotes Tat
T17539 35011-35020 Protein denotes IκB-α RNA
T17540 35063-35066 Protein denotes Tat
T17541 35077-35082 Protein denotes IκB-α
T17542 34854-34862 Binding denotes findings
T17543 34854-34862 Binding denotes findings
T17544 34929-34936 Transcription denotes absence
T19167 35128-35131 Protein denotes Tat
T19168 35145-35150 Protein denotes NF-κB
T19169 35207-35213 Protein denotes MIP-1α
T19170 35234-35239 Protein denotes IκB-α
T19171 35193-35203 Positive_regulation denotes activation
T19172 35217-35228 Binding denotes interacting
T19173 35164-35172 Positive_regulation denotes promotes
T19174 35273-35276 Protein denotes Tat
T19175 35290-35295 Protein denotes NF-κB
T19176 35327-35333 Protein denotes MIP-1α
T19177 35313-35323 Gene_expression denotes expression
T19178 35277-35285 Regulation denotes affected
T19179 35382-35393 Protein denotes Tat protein
T19180 35407-35415 Protein denotes HXB2 Env
T19181 35371-35377 Gene_expression denotes detect
T19182 35565-35581 Protein denotes siRNA Tat, siRNA
T19183 35628-35631 Protein denotes Tat
T19184 35681-35686 Protein denotes NF-κB
T19185 35632-35642 Gene_expression denotes expression
T19186 35615-35623 Regulation denotes modulate
T19187 35743-35746 Protein denotes Tat
T19188 35751-35754 Protein denotes p24
T19189 35836-35839 Protein denotes Tat
T19190 35729-35739 Gene_expression denotes expression
T19191 35729-35739 Gene_expression denotes expression
T19192 35840-35851 Gene_expression denotes transfected
T19193 35840-35851 Positive_regulation denotes transfected
T19194 38130-38135 Protein denotes NF-κB
T19195 38220-38223 Protein denotes Tat
T19196 38266-38269 Protein denotes Tat
T19197 38292-38295 Protein denotes Tat
T19198 38328-38331 Protein denotes Tat
T19199 38182-38189 Positive_regulation denotes induced
T19200 38270-38278 Gene_expression denotes negative
T19201 38270-38278 Gene_expression denotes negative
T19202 38302-38311 Positive_regulation denotes increased
T19203 38332-38340 Gene_expression denotes positive
T19204 38375-38380 Protein denotes IκB-α
T19205 38458-38463 Protein denotes IκB-α
T19206 38493-38496 Protein denotes Tat
T19207 38360-38371 Protein_catabolism denotes Degradation
T19208 38537-38540 Protein denotes IKK
T19209 38628-38631 Protein denotes Tat
T19210 38554-38561 Positive_regulation denotes induced
T19211 38695-38700 Protein denotes NF-κB
T19212 38876-38881 Protein denotes NF-κB
T19213 38701-38711 Positive_regulation denotes activation
T19214 38928-38931 Protein denotes Tat
T19215 38962-38967 Protein denotes IκB-α
T19216 39007-39013 Protein denotes MIP-1α
T19217 39030-39033 Protein denotes p65
T19218 39113-39116 Protein denotes Tat
T19219 38936-38956 Binding denotes coimmunoprecipitated
T19220 39014-39024 Gene_expression denotes expression
T19221 39097-39109 Negative_regulation denotes interference
T19222 38993-39002 Positive_regulation denotes activated
T19223 39147-39150 Protein denotes Tat
T19224 39155-39158 Protein denotes p65
T19225 39186-39200 Protein denotes NF-κB enhancer
T19226 39204-39210 Protein denotes MIP-1α
T19227 39222-39225 Protein denotes p65
T19228 39226-39235 Positive_regulation denotes occupancy
T19229 39240-39249 Negative_regulation denotes abolished
T19230 39374-39379 Protein denotes IκB-α
T19231 39384-39387 Protein denotes p65
T19232 39405-39408 Protein denotes p65
T19233 39433-39439 Protein denotes MIP-1α
T19234 39476-39491 Protein denotes MIP-1α promoter
T19235 39521-39524 Protein denotes p65
T19236 39358-39368 Binding denotes associated
T19237 39358-39368 Binding denotes associated
T19238 39440-39450 Gene_expression denotes expression
T19239 39506-39517 Binding denotes recruitment
T19240 39419-39429 Positive_regulation denotes activation
T19241 39393-39400 Positive_regulation denotes induced
T23606 39578-39583 Protein denotes NF-κB
T23607 39602-39626 Protein denotes HIV-1 Tat transactivator
T23608 39584-39594 Positive_regulation denotes activation
T23609 39655-39658 Protein denotes Tat
T23610 39704-39715 Protein denotes p65 subunit
T23611 39719-39724 Protein denotes NF-κB
T23612 39772-39787 Protein denotes IκB-α repressor
T23613 39834-39837 Protein denotes Tat
T23614 39853-39858 Protein denotes NF-κB
T23615 39887-39892 Protein denotes IκB-α
T23616 39897-39900 Protein denotes p65
T23617 39688-39696 Transcription denotes activity
T23618 39688-39696 Transcription denotes activity
T23619 39752-39762 Binding denotes interacted
T23620 39752-39762 Binding denotes interacted
T23621 39844-39852 Positive_regulation denotes activate
T23622 39870-39881 Binding denotes interaction
T23623 39870-39881 Binding denotes interaction
T23624 39659-39667 Positive_regulation denotes enhanced
T23625 39659-39667 Positive_regulation denotes enhanced
T23626 39844-39852 Positive_regulation denotes activate
T23627 39844-39852 Positive_regulation denotes activate
T23628 39919-39924 Protein denotes NF-κB
T23629 40018-40021 Protein denotes Tat
T23630 40022-40032 Gene_expression denotes expression
T23631 40006-40013 Negative_regulation denotes silence
T23632 40083-40088 Protein denotes NF-κB
T23633 40219-40224 Protein denotes NF-κB
T23634 40264-40267 Protein denotes IKK
T23635 40283-40288 Protein denotes IκB-α
T23636 40319-40322 Protein denotes Tat
T23637 40225-40235 Positive_regulation denotes activation
T23638 40268-40278 Positive_regulation denotes activation
T23639 40289-40300 Protein_catabolism denotes degradation
T23640 40268-40278 Positive_regulation denotes activation
T23641 40351-40354 Protein denotes IKK
T23642 40385-40390 Protein denotes IκB-α
T23643 40396-40401 Protein denotes NF-κB
T23644 40448-40451 Protein denotes Tat
T23645 40503-40511 Protein denotes Tat gene
T23646 40372-40381 Gene_expression denotes synthesis
T23647 40372-40381 Gene_expression denotes synthesis
T23648 40420-40428 Positive_regulation denotes elevated
T23649 40486-40495 Negative_regulation denotes silencing
T23650 40575-40578 Protein denotes Tat
T23651 40592-40597 Protein denotes NF-κB
T23652 40629-40632 Protein denotes IKK
T23653 40663-40668 Protein denotes IκB-α
T23654 40579-40587 Positive_regulation denotes enhanced
T23655 40615-40624 Regulation denotes affecting
T23656 40615-40624 Regulation denotes affecting
T23657 40689-40694 Protein denotes NF-κB
T23658 40742-40745 Protein denotes Tat
T23659 40776-40779 Protein denotes Tat
T23660 40822-40827 Protein denotes NF-κB
T23661 40861-40866 Protein denotes IκB-α
T23662 40695-40705 Positive_regulation denotes activation
T23663 40746-40757 Gene_expression denotes transfected
T23664 40746-40757 Positive_regulation denotes transfected
T23665 40872-40875 Protein denotes Tat
T23666 40900-40905 Protein denotes NF-κB
T23667 40964-40969 Protein denotes IκB-α
T23668 41015-41032 Protein denotes IκB-α/p65 complex
T23669 40886-40896 Positive_regulation denotes activation
T23670 40926-40937 Binding denotes association
T23671 40997-41007 Gene_expression denotes generation
T23672 41066-41069 Protein denotes Tat
T23673 41098-41103 Protein denotes IκB-α
T23674 41107-41110 Protein denotes p65
T23675 41129-41134 Protein denotes IκB-α
T23676 41149-41152 Protein denotes p65
T23677 41070-41078 Binding denotes competed
T23678 41087-41094 Binding denotes binding
T23679 41135-41145 Negative_regulation denotes repression
T23680 41135-41145 Negative_regulation denotes repression
T23681 41115-41124 Negative_regulation denotes prevented
T23682 41115-41124 Negative_regulation denotes prevented
T23683 41181-41186 Protein denotes NF-κB
T23684 41199-41202 Protein denotes Tat
T23685 41219-41222 Protein denotes p65
T23686 41241-41244 Protein denotes p65
T23687 41269-41283 Protein denotes NF-κB enhancer
T23688 41378-41381 Protein denotes p65
T23689 41434-41437 Protein denotes Tat
T23690 41486-41489 Protein denotes p65
T23691 41187-41197 Positive_regulation denotes activation
T23692 41203-41213 Binding denotes associated
T23693 41367-41374 Binding denotes binding
T23694 41417-41428 Binding denotes association
T23695 41521-41524 Protein denotes Tat
T23696 41602-41605 Protein denotes p65
T23697 41610-41615 Protein denotes NF-κB
T23698 41580-41587 Binding denotes binding
T23699 41616-41626 Positive_regulation denotes activation
T23700 41645-41648 Protein denotes Tat
T23701 41735-41742 Protein denotes ankyrin
T23702 41746-41751 Protein denotes IκB-α
T23703 41792-41797 Protein denotes IκB-α
T23704 41714-41721 Binding denotes binding
T23705 41714-41721 Binding denotes binding
T23706 41714-41721 Binding denotes binding
T23707 41798-41808 Negative_regulation denotes inhibition
T23708 41697-41705 Positive_regulation denotes required
T23709 41697-41705 Positive_regulation denotes required
T23710 41697-41705 Positive_regulation denotes required
T23711 41853-41856 Protein denotes Tat
T23712 41903-41908 Protein denotes NF-κB
T23713 41926-41941 Protein denotes IκB-α repressor
T23714 41953-41956 Protein denotes p65
T23715 41966-41971 Protein denotes IκB-α
T23716 41999-42002 Protein denotes p65
T23717 41889-41899 Regulation denotes regulation
T23718 41912-41921 Negative_regulation denotes hijacking
T23719 41943-41952 Negative_regulation denotes shielding
T23720 41943-41952 Negative_regulation denotes shielding
T23721 42003-42010 Binding denotes binding
T23722 41857-41866 Negative_regulation denotes abolished
T23723 41857-41866 Negative_regulation denotes abolished
T23724 41985-41994 Negative_regulation denotes enforcing
T23725 42039-42042 Protein denotes Tat
T23726 42057-42062 Protein denotes NF-κB
T23727 42102-42113 Protein denotes Tat mutants
T23728 42213-42218 Protein denotes NF-κB
T23729 42247-42253 Protein denotes MIP-1α
T23730 42255-42259 Protein denotes CSF3
T23731 42261-42264 Protein denotes LTA
T23732 42266-42272 Protein denotes NFKBIA
T23733 42277-42281 Protein denotes TLR2
T23734 42043-42053 Positive_regulation denotes activation
T23735 42043-42053 Positive_regulation denotes activation
T23736 42187-42197 Gene_expression denotes expression
T23737 42187-42197 Gene_expression denotes expression
T23738 42187-42197 Gene_expression denotes expression
T23739 42187-42197 Gene_expression denotes expression
T23740 42187-42197 Gene_expression denotes expression
T23741 42162-42174 Positive_regulation denotes up-regulated
T23742 42162-42174 Positive_regulation denotes up-regulated
T23743 42162-42174 Positive_regulation denotes up-regulated
T23744 42162-42174 Positive_regulation denotes up-regulated
T23745 42162-42174 Positive_regulation denotes up-regulated
T23746 42318-42321 Protein denotes Tat
T23747 42351-42354 Protein denotes p65
T23748 42362-42377 Protein denotes NF-κB enhancers
T23749 42336-42347 Binding denotes recruitment
T23750 42410-42419 Localization denotes recovered
T23751 42322-42331 Positive_regulation denotes increased
T23752 42459-42462 Protein denotes p65
T23753 42477-42480 Protein denotes Tat
T23754 42498-42513 Protein denotes NF-κB enhancers
T23755 42534-42537 Protein denotes Tat
T23756 42553-42564 Protein denotes NF-κB sites
T23757 42581-42584 Protein denotes p65
T23758 42481-42490 Positive_regulation denotes occupancy
T23759 42538-42545 Binding denotes binding
T23760 42463-42472 Negative_regulation denotes abolished
T23761 42639-42642 Protein denotes Tat
T23762 42653-42656 Protein denotes p65
T23763 42677-42682 Protein denotes IκB-α
T23764 42722-42729 Protein denotes p65 DNA
T23765 42643-42652 Positive_regulation denotes displaced
T23766 42666-42673 Binding denotes binding
T23767 42708-42717 Positive_regulation denotes increased
T23768 42643-42652 Positive_regulation denotes displaced
T23769 42792-42795 Protein denotes Tat
T23770 42832-42835 Protein denotes p65
T23771 42843-42848 Protein denotes NF-κB
T23772 42889-42892 Protein denotes p65
T23773 42933-42936 Protein denotes p65
T23774 42956-42961 Protein denotes IκB-α
T23775 42817-42828 Binding denotes recruitment
T23776 42872-42883 Binding denotes associating
T23777 42921-42929 Binding denotes assembly
T23778 42803-42812 Positive_regulation denotes increased
T23779 42976-42981 Protein denotes IκB-α
T23780 43010-43025 Protein denotes NF-κB enhancers
T23781 43040-43043 Protein denotes Tat
T23782 43083-43086 Protein denotes Tat
T23783 42992-43002 Binding denotes associated
T23784 43071-43079 Binding denotes presence
T23785 43140-43145 Protein denotes IκB-α
T23786 43214-43219 Protein denotes IκB-α
T23787 43246-43266 Protein denotes hystone deacetylases
T23788 43274-43287 Protein denotes hes1 promoter
T23789 43325-43330 Protein denotes TNF-α
T23790 43351-43358 Protein denotes histone
T23791 43375-43379 Protein denotes hes1
T23792 43230-43240 Binding denotes associated
T23793 43230-43240 Binding denotes associated
T23794 43331-43342 Positive_regulation denotes stimulation
T23795 43359-43370 Binding denotes acetylation
T23796 43396-43406 Positive_regulation denotes activation
T23797 43343-43350 Positive_regulation denotes causing
T23798 43471-43476 Protein denotes NF-κB
T23799 43523-43526 Protein denotes Tat
T23800 43574-43579 Protein denotes IκB-α
T23801 43565-43573 Negative_regulation denotes removing
T23802 44076-44079 Protein denotes Tat
T23803 44096-44101 Protein denotes NF-κB
T23804 44182-44193 Protein denotes Tat protein
T23805 44235-44240 Protein denotes NF-κB
T23806 44269-44274 Protein denotes NF-κB
T23807 44287-44290 Protein denotes Tat
T23808 44324-44329 Protein denotes IκB-α
T23809 44361-44364 Protein denotes Tat
T23810 44370-44375 Protein denotes IκB-α
T23811 44380-44383 Protein denotes p65
T23812 44404-44410 Protein denotes MIP-1α
T23813 44435-44438 Protein denotes Tat
T23814 44443-44446 Protein denotes p65
T23815 44453-44456 Protein denotes Tat
T23816 44474-44480 Protein denotes MIP-1α
T23817 44481-44495 Protein denotes NF-κB enhancer
T23818 44537-44540 Protein denotes p65
T23819 44336-44357 Binding denotes coimmunoprecipitation
T23820 44336-44357 Binding denotes coimmunoprecipitation
T23821 44411-44421 Gene_expression denotes expression
T23822 44411-44421 Gene_expression denotes expression
T23823 44411-44421 Gene_expression denotes expression
T23824 44457-44466 Binding denotes occupancy
T23825 44522-44533 Binding denotes recruitment
T23826 44391-44400 Positive_regulation denotes induction
T23827 44391-44400 Positive_regulation denotes induction
T23828 44391-44400 Positive_regulation denotes induction
T23829 44593-44596 Protein denotes Tat
T23830 44631-44634 Protein denotes p65
T23831 44639-44644 Protein denotes IκB-α
T23832 44714-44719 Protein denotes NF-κB
T23833 44781-44785 Protein denotes IL-6
T23834 44795-44800 Protein denotes TNF-α
T23835 44811-44817 Protein denotes MIP-1α
T23836 44703-44710 Regulation denotes control
T23837 44724-44739 Gene_expression denotes hyper-expressed
T23838 44724-44739 Gene_expression denotes hyper-expressed
T23839 44724-44739 Gene_expression denotes hyper-expressed
T23840 44848-44853 Protein denotes TNF-α
T23841 44858-44862 Protein denotes IL-6
T23842 44864-44867 Protein denotes Tat
T23843 45055-45058 Protein denotes Tat
T23844 45159-45162 Protein denotes Tat
T23845 45168-45171 Protein denotes p65
T23846 45179-45193 Protein denotes NF-κB enhancer
T23847 45228-45233 Protein denotes IκB-α
T23848 45275-45280 Protein denotes NF-κB
T23849 45299-45302 Protein denotes Tat
T23850 45412-45415 Protein denotes Tat
T23851 45645-45650 Protein denotes NF-κB
T23852 45631-45641 Negative_regulation denotes inhibition
T23853 45804-45809 Protein denotes NF-κB
T23854 45860-45863 Protein denotes IKK
T23855 45985-45990 Protein denotes NF-κB
T23856 45810-45820 Negative_regulation denotes inhibitors
T23857 45810-45820 Negative_regulation denotes inhibitors
T23858 46088-46091 Protein denotes Tat
T23859 46102-46107 Protein denotes NF-κB
T23860 46140-46145 Protein denotes IκB-α
T23861 46150-46153 Protein denotes p65
T23862 46204-46207 Protein denotes Tat
T23863 46092-46101 Positive_regulation denotes activates
T23864 46123-46134 Binding denotes interaction
T23865 46123-46134 Binding denotes interaction
T23866 46092-46101 Positive_regulation denotes activates
T23867 46092-46101 Positive_regulation denotes activates
T24297 16062-16065 Protein denotes Tat
T24298 16110-16115 Protein denotes NF-κB
T24299 16194-16212 Protein denotes siRNA Tat or siRNA
T24300 16342-16345 Protein denotes p24
T24301 16388-16391 Protein denotes Tat
T24302 16457-16467 Protein denotes luciferase
T24303 16392-16402 Gene_expression denotes expression
T24304 16565-16568 Protein denotes p65
T24305 16573-16576 Protein denotes p50
T24306 16592-16597 Protein denotes NF-κB
T24307 16640-16645 Protein denotes NF-κB
T24308 16715-16718 Protein denotes p65
T24309 16723-16728 Protein denotes IκB-α
T24310 16831-16834 Protein denotes p65
T24311 16839-16860 Protein denotes anti-IκB-α antibodies
T24312 16701-16711 Gene_expression denotes expression
T24313 16701-16711 Gene_expression denotes expression
T24314 16862-16890 Protein denotes Histone H1 and Hexokinase II
T24315 17089-17092 Protein denotes IKK
T24316 17155-17165 Protein denotes HTScan IKK
T25072 20207-20210 Protein denotes Tat
T25073 20224-20229 Protein denotes NF-κB
T25074 20285-20290 Protein denotes IκB-α
T25075 20313-20318 Protein denotes NF-κB
T25076 20268-20279 Binding denotes associating
T25077 20319-20329 Negative_regulation denotes repression
T25078 20374-20385 Protein denotes p3xFLAG-Tat
T25079 20669-20672 Protein denotes p65
T25080 20674-20677 Protein denotes p50
T25081 20682-20686 Protein denotes FLAG
T25082 20687-20690 Protein denotes Tat
T25083 20706-20711 Protein denotes NF-κB
T25084 20754-20759 Protein denotes NF-κB
T25085 20929-20932 Protein denotes p65
T25086 20934-20943 Protein denotes anti-FLAG
T25087 20945-20972 Protein denotes anti-Histone H1, anti-IκB-α
T25088 20977-21006 Protein denotes anti-Hexokinase-II antibodies
T25089 21175-21185 Protein denotes HTScan IKK
T25090 21498-21545 Protein denotes protein G-Sepharose-coupled anti-IκB-α antibody
T25091 21637-21640 Protein denotes p65
T25092 21642-21651 Protein denotes anti-FLAG
T25093 21656-21677 Protein denotes anti-IκB-α antibodies
T26369 23413-23416 Protein denotes p65
T26370 23426-23431 Protein denotes IκB-α
T26371 23432-23442 Negative_regulation denotes inhibition
T26372 23404-23412 Negative_regulation denotes relieves
T26373 23490-23509 Protein denotes mutant Tat proteins
T26374 23515-23517 Protein denotes HA
T26375 23518-23523 Protein denotes IκB-α
T26376 23571-23579 Protein denotes FLAG-Tat
T26377 23581-23585 Protein denotes FLAG
T26378 23586-23589 Protein denotes Tat
T26379 23725-23744 Protein denotes mutant Tat proteins
T26380 23940-23943 Protein denotes p65
T26381 23990-23992 Protein denotes HA
T26382 23993-23998 Protein denotes IκB-α
T26383 24032-24036 Protein denotes FLAG
T26384 24037-24040 Protein denotes Tat
T26385 24044-24048 Protein denotes FLAG
T26386 24049-24052 Protein denotes Tat
T26387 24081-24083 Protein denotes HA
T26388 24084-24089 Protein denotes IκB-α
T26389 24118-24134 Protein denotes anti-HA antibody
T26390 24394-24401 Protein denotes p65 DNA
T26391 24402-24409 Binding denotes binding
T26392 24491-24493 Protein denotes κB
T26393 24584-24586 Protein denotes HA
T26394 24587-24590 Protein denotes IκB
T26395 24601-24609 Protein denotes FLAG-Tat
T26396 24613-24617 Protein denotes FLAG
T26397 24618-24621 Protein denotes Tat
T26398 24739-24744 Protein denotes NF-κB
T26399 24993-25007 Protein denotes pCMV4-HA-IκB-α
T26400 25018-25029 Protein denotes p3xFLAG-Tat
T26401 25033-25040 Protein denotes p3xFLAG
T26402 25041-25044 Protein denotes Tat
T26403 25078-25088 Protein denotes luciferase
T26404 25169-25184 Protein denotes β-galactosidase
T26405 25258-25278 Protein denotes pκBLuc plasmid alone
T26406 25238-25250 Gene_expression denotes transfection
T26407 25429-25432 Protein denotes p65
T26408 25434-25441 Protein denotes anti-HA
T26409 25443-25452 Protein denotes anti-FLAG
T26410 25457-25482 Protein denotes anti-γ-tubulin antibodies
T27133 27379-27382 Protein denotes Tat
T27134 27399-27402 Protein denotes p65
T27135 27383-27393 Binding denotes associates
T27136 27527-27538 Protein denotes p3xFLAG-Tat
T27137 27540-27547 Protein denotes p3xFLAG
T27138 27548-27551 Protein denotes Tat
T27139 27647-27664 Protein denotes FLAG-Tat proteins
T27140 27886-27889 Protein denotes GST
T27141 27890-27893 Protein denotes Tat
T27142 27895-27898 Protein denotes GST
T27143 27899-27902 Protein denotes Tat
T27144 27935-27938 Protein denotes GST
T27145 27939-27942 Protein denotes Tat
T27146 28065-28068 Protein denotes GST
T27147 28150-28153 Protein denotes p65
T27148 28157-28176 Protein denotes anti-GST antibodies
T27149 28224-28243 Protein denotes mutant p65 proteins
T27150 28431-28453 Protein denotes mutant HA-p65 proteins
T27151 28483-28499 Protein denotes anti-HA antibody
T27152 28459-28477 Binding denotes immunoprecipitated
T27153 28459-28477 Binding denotes immunoprecipitated
T27154 28623-28646 Protein denotes Recombinant p65 protein
T27155 28726-28731 Protein denotes NF-κB
T27156 28810-28814 Protein denotes FLAG
T27157 28815-28818 Protein denotes Tat
T27158 28822-28826 Protein denotes FLAG
T27159 28827-28830 Protein denotes Tat
T28179 31394-31397 Protein denotes Tat
T28180 31412-31415 Protein denotes p65
T28181 31440-31445 Protein denotes NF-κB
T28182 31480-31495 Protein denotes NF-κB enhancers
T28183 31514-31517 Protein denotes p65
T28184 31535-31540 Protein denotes IκB-α
T28185 31466-31475 Binding denotes occupying
T28186 31518-31529 Binding denotes recruitment
T28187 31500-31509 Positive_regulation denotes promoting
T28188 31598-31605 Protein denotes p3xFLAG
T28189 31606-31609 Protein denotes Tat
T28190 31636-31643 Protein denotes p3xFLAG
T28191 31644-31647 Protein denotes Tat
T28192 31686-31693 Protein denotes p65 RNA
T28193 31770-31788 Protein denotes siRNA p65 or siRNA
T28194 31694-31706 Negative_regulation denotes interference
T28195 31929-31935 Protein denotes MIP-1α
T28196 31982-31987 Protein denotes GAPDH
T28197 31915-31925 Gene_expression denotes expression
T28198 31915-31925 Gene_expression denotes expression
T28199 31902-31910 Positive_regulation denotes evaluate
T28200 31902-31910 Positive_regulation denotes evaluate
T28201 32056-32063 Protein denotes p3xFLAG
T28202 32064-32067 Protein denotes Tat
T28203 32132-32149 Protein denotes anti-p65 antibody
T28204 32340-32349 Protein denotes siRNA p65
T28205 32624-32629 Protein denotes IκB-α
T28206 32695-32714 Protein denotes anti-IκB-α antibody
T29011 35917-35922 Protein denotes NF-κB
T29012 35949-35955 Protein denotes MIP-1α
T29013 35988-35993 Protein denotes IκB-α
T29014 35998-36001 Protein denotes p65
T29015 35956-35966 Gene_expression denotes expression
T29016 35971-35982 Binding denotes interaction
T29017 35936-35944 Positive_regulation denotes enhances
T29018 36046-36055 Protein denotes siRNA Tat
T29019 36196-36199 Protein denotes p24
T29020 36282-36285 Protein denotes Tat
T29021 36327-36330 Protein denotes p24
T29022 36286-36296 Gene_expression denotes expression
T29023 36374-36377 Protein denotes p65
T29024 36385-36390 Protein denotes NF-κB
T29025 36474-36479 Protein denotes NF-κB
T29026 36407-36422 Entity denotes oligonucleotide
T29027 36363-36370 Binding denotes binding
T29028 36535-36540 Protein denotes IκB-α
T29029 36635-36654 Protein denotes anti-IκB-α antibody
T29030 36629-36634 Gene_expression denotes using
T29031 36755-36758 Protein denotes IKK
T29032 36823-36833 Protein denotes HTScan IKK
T29033 37069-37115 Protein denotes protein G-Sepharose-coupled anti-FLAG antibody
T29034 37207-37210 Protein denotes p65
T29035 37212-37221 Protein denotes anti-FLAG
T29036 37226-37247 Protein denotes anti-IκB-α antibodies
T29037 37296-37305 Protein denotes siRNA Tat
T29038 37307-37316 Protein denotes siRNA p65
T29039 37528-37534 Protein denotes MIP-1α
T29040 37535-37545 Gene_expression denotes expression
T29041 37617-37635 Protein denotes siRNA Tat or siRNA
T29042 37922-37928 Protein denotes MIP-1α
T29043 37933-37938 Protein denotes GAPDH
T29403 43896-43902 Protein denotes MIP-1α
T29404 43930-43945 Protein denotes IκB-α repressor
T29405 43955-43969 Protein denotes NF-κB enhancer
T29406 44004-44007 Protein denotes p65
T6022 8167-8170 Protein denotes Rad
T6023 8544-8559 Protein denotes siRNA Tat sense
T6024 8561-8582 Protein denotes CUGCUUGUACCAAUUGCUAUU
T6025 8587-8596 Protein denotes siRNA Tat
T6026 8747-8750 Protein denotes p65
T6027 8755-8760 Protein denotes IκB-α
T6028 8780-8796 Protein denotes SMART pool siRNA
T6029 8797-8800 Protein denotes p65
T6030 8805-8810 Protein denotes IκB-α
T6031 8731-8743 Negative_regulation denotes interference
T6032 8731-8743 Negative_regulation denotes interference
T29392 43641-43647 Protein denotes MIP-1α
T29393 43678-43687 Protein denotes HIV-1 Tat
T29394 43664-43674 Positive_regulation denotes activation
T29395 43707-43710 Protein denotes Tat
T29396 43712-43717 Protein denotes IκB-α
T29397 43731-43745 Protein denotes NF-κB enhancer
T29398 43753-43768 Protein denotes MIP-1α promoter
T29399 43696-43703 Negative_regulation denotes absence
T29400 43718-43726 Positive_regulation denotes occupies
T29401 43780-43789 Binding denotes interacts
T29402 43878-43881 Protein denotes Tat
T29407 44008-44013 Protein denotes NF-κB
T29408 44029-44043 Protein denotes NF-κB enhancer
T29409 43903-43913 Gene_expression denotes expression
T29410 43917-43925 Positive_regulation denotes removing
T29411 43993-44000 Binding denotes binding
T29412 44014-44021 Binding denotes complex
T29413 43882-43891 Positive_regulation denotes activates
T29414 43978-43988 Positive_regulation denotes increasing
R3988 T4353 T4354 themeOf binding,enhances
R3989 T4353 T4355 themeOf binding,enhances
R3991 T4356 T4357 themeOf NF-κB,deregulation
R631 T903 T906 causeOf Tat,activates
R632 T903 T908 causeOf Tat,activates
R633 T904 T906 themeOf NF-κB,activates
R634 T905 T907 themeOf IκB-α,interaction
R635 T907 T908 themeOf interaction,activates
R636 T909 T910 themeOf κB,upregulated
R637 T911 T912 themeOf NF-κB,deregulation
R638 T913 T917 causeOf HIV-1 Tat transactivator,activated
R639 T914 T917 themeOf NF-κB,activated
R640 T916 T918 themeOf NF-κB complex,binding
R641 T918 T919 themeOf binding,preventing
R642 T920 T924 themeOf Tat,associated
R643 T921 T924 themeOf p65 subunit,associated
R644 T930 T943 themeOf Tat,bound
R645 T930 T945 causeOf Tat,activated
R646 T931 T942 themeOf MIP-1α,expression
R647 T934 T943 themeOf NF-κB enhancer,bound
R648 T935 T944 themeOf p65,recruitment
R649 T936 T944 themeOf IκB-α,recruitment
R650 T942 T945 themeOf expression,activated
R651 T946 T950 themeOf NF-κB,activation
R652 T947 T951 themeOf Tat,interaction
R653 T948 T951 themeOf IκB-α,interaction
R3776 T4184 T4185 themeOf κB,regulate
R3781 T4196 T4199 themeOf NF-κB,Inhibitors
R3782 T4196 T4201 themeOf NF-κB,associate
R3783 T4196 T4202 themeOf NF-κB,binding
R3784 T4197 T4200 themeOf IκB,Inhibitors
R3785 T4197 T4203 themeOf IκB,binding
R3786 T4198 T4201 themeOf NF-κB,associate
R3789 T4204 T4209 themeOf NF-κB,activation
R3791 T4205 T4210 themeOf IκB kinase,activated
R3792 T4205 T4212 themeOf IκB kinase,phosphorylates
R3793 T4206 T4211 themeOf IKK,activated
R3794 T4206 T4213 themeOf IKK,phosphorylates
R3795 T4206 T4215 themeOf IKK,degradation
R3797 T4207 T4214 themeOf IκB,phosphorylates
R3798 T4207 T4216 themeOf IκB,degradation
R3800 T4208 T4219 themeOf NF-κB,complex
R3804 T4215 T4217 themeOf degradation,releases
R3805 T4215 T4220 themeOf degradation,target
R3807 T4216 T4218 themeOf degradation,releases
R3808 T4216 T4221 themeOf degradation,target
R3811 T4222 T4225 themeOf IκB-α,inhibitor
R3812 T4222 T4228 themeOf IκB-α,degraded
R3813 T4222 T4229 themeOf IκB-α,phosphorylated
R3815 T4222 T4227 partOf IκB-α,Ser36
R3816 T4223 T4226 themeOf NF-κB,inhibitor
R3817 T4224 T4230 themeOf IKK,phosphorylated
R3818 T4224 T4227 partOf IKK,Ser36
R3820 T4227 T4229 Site Ser36,phosphorylated
R3821 T4227 T4230 Site Ser36,phosphorylated
R3823 T4231 T4235 themeOf NF-κB,enhanced
R3824 T4231 T4236 themeOf NF-κB,enhanced
R3825 T4231 T4238 themeOf NF-κB,enhanced
R3827 T4232 T4237 themeOf p65,phosphorylation
R3828 T4233 T4235 causeOf PKA,enhanced
R3830 T4234 T4236 causeOf MSK1,enhanced
R3832 T4237 T4238 causeOf phosphorylation,enhanced
R3834 T4239 T4244 themeOf p65,Acetylation
R3835 T4239 T4247 themeOf p65,association
R3836 T4240 T4245 themeOf Lys218,Acetylation
R3837 T4241 T4246 themeOf Lys221,Acetylation
R3838 T4242 T4247 themeOf IκB-α,association
R3839 T4243 T4248 themeOf p65,enhances
R3842 T4249 T4253 themeOf NF-κB,Post-activation
R3843 T4250 T4255 themeOf NF-κB,control
R3845 T4253 T4254 themeOf Post-activation,regulated
R3850 T4259 T4261 causeOf p65,down-regulate
R3851 T4260 T4261 themeOf NF-κB,down-regulate
R3854 T4262 T4264 themeOf NF-κB,activation
R3855 T4263 T4265 themeOf NF-κB,expression
R3856 T4264 T4266 causeOf activation,enhances
R3858 T4265 T4266 themeOf expression,enhances
R3860 T4268 T4271 themeOf gp120 viral envelope,binding
R3861 T4269 T4271 themeOf CD4,binding
R3863 T4270 T4272 themeOf NF-κB,induces
R3865 T4271 T4272 causeOf binding,induces
R3866 T4273 T4274 themeOf early encoded HIV-1 Tat protein,interacts
R3867 T4275 T4280 themeOf Tat,binds
R3868 T4275 T4281 themeOf Tat,binds
R3869 T4275 T4282 themeOf Tat,binds
R3870 T4275 T4283 themeOf Tat,binds
R3871 T4275 T4284 themeOf Tat,binds
R3872 T4275 T4285 themeOf Tat,binds
R3873 T4275 T4286 themeOf Tat,binds
R3874 T4276 T4281 themeOf tumor necrosis factor β,binds
R3875 T4277 T4282 themeOf TNFβ,binds
R3876 T4277 T4285 themeOf TNFβ,binds
R3877 T4277 T4286 themeOf TNFβ,binds
R3878 T4278 T4283 themeOf interleukin-6,binds
R3879 T4278 T4285 themeOf interleukin-6,binds
R3880 T4279 T4284 themeOf IL-6,binds
R3883 T4279 T4286 themeOf IL-6,binds
R3887 T4287 T4295 themeOf Tat,interacting
R3888 T4287 T4296 themeOf Tat,interacting
R3889 T4287 T4297 themeOf Tat,interacting
R3890 T4287 T4298 themeOf Tat,interacting
R3891 T4287 T4299 themeOf Tat,interacting
R3892 T4287 T4300 themeOf Tat,interacting
R3893 T4287 T4301 themeOf Tat,interacting
R3894 T4287 T4302 themeOf Tat,interacting
R3895 T4287 T4303 themeOf Tat,interacting
R3896 T4287 T4304 themeOf Tat,interacting
R3897 T4287 T4305 themeOf Tat,interacting
R3898 T4287 T4306 themeOf Tat,interacting
R3899 T4287 T4307 themeOf Tat,interacting
R3900 T4287 T4308 themeOf Tat,interacting
R3901 T4287 T4309 themeOf Tat,interacting
R3902 T4287 T4310 themeOf Tat,interacting
R3903 T4287 T4311 themeOf Tat,interacting
R3904 T4287 T4312 themeOf Tat,interacting
R3905 T4287 T4313 themeOf Tat,interacting
R3906 T4287 T4314 themeOf Tat,interacting
R3907 T4287 T4315 themeOf Tat,interacting
R3908 T4289 T4295 themeOf E2F-4,interacting
R3909 T4289 T4301 themeOf E2F-4,interacting
R3910 T4289 T4302 themeOf E2F-4,interacting
R3911 T4289 T4303 themeOf E2F-4,interacting
R3912 T4290 T4296 themeOf C/EBPβ,interacting
R3913 T4290 T4304 themeOf C/EBPβ,interacting
R3914 T4290 T4305 themeOf C/EBPβ,interacting
R3915 T4290 T4306 themeOf C/EBPβ,interacting
R3916 T4290 T4313 themeOf C/EBPβ,interacting
R3917 T4291 T4297 themeOf cyclin T1/CDK9,interacting
R3918 T4291 T4307 themeOf cyclin T1/CDK9,interacting
R3919 T4291 T4308 themeOf cyclin T1/CDK9,interacting
R3920 T4291 T4309 themeOf cyclin T1/CDK9,interacting
R3921 T4291 T4314 themeOf cyclin T1/CDK9,interacting
R3922 T4292 T4298 themeOf histone acetyltransferases,interacting
R3923 T4292 T4301 themeOf histone acetyltransferases,interacting
R3924 T4292 T4304 themeOf histone acetyltransferases,interacting
R3925 T4292 T4307 themeOf histone acetyltransferases,interacting
R3926 T4292 T4310 themeOf histone acetyltransferases,interacting
R3927 T4292 T4311 themeOf histone acetyltransferases,interacting
R3928 T4292 T4313 themeOf histone acetyltransferases,interacting
R3929 T4292 T4314 themeOf histone acetyltransferases,interacting
R3930 T4292 T4315 themeOf histone acetyltransferases,interacting
R3931 T4293 T4299 themeOf p300,interacting
R3932 T4293 T4302 themeOf p300,interacting
R3933 T4293 T4305 themeOf p300,interacting
R3934 T4293 T4308 themeOf p300,interacting
R3935 T4293 T4310 themeOf p300,interacting
R3936 T4293 T4312 themeOf p300,interacting
R3937 T4293 T4313 themeOf p300,interacting
R3938 T4293 T4314 themeOf p300,interacting
R3939 T4293 T4315 themeOf p300,interacting
R3940 T4294 T4300 themeOf CBP,interacting
R3941 T4294 T4303 themeOf CBP,interacting
R3942 T4294 T4306 themeOf CBP,interacting
R3943 T4294 T4309 themeOf CBP,interacting
R3944 T4294 T4311 themeOf CBP,interacting
R3945 T4294 T4312 themeOf CBP,interacting
R3946 T4294 T4315 themeOf CBP,interacting
R3952 T4316 T4319 themeOf Tat,binding
R3953 T4316 T4320 themeOf Tat,binding
R3954 T4316 T4321 themeOf Tat,binding
R3955 T4317 T4320 themeOf Flk1,binding
R3956 T4318 T4321 themeOf KDR,binding
R3958 T4323 T4324 themeOf Tat,expressed
R3960 T4325 T4331 causeOf Tat,induced
R3961 T4325 T4334 causeOf Tat,increased
R3962 T4325 T4335 causeOf Tat,induced
R3963 T4325 T4336 causeOf Tat,induced
R3964 T4326 T4331 themeOf IKK,induced
R3965 T4326 T4332 themeOf IKK,degradation
R3966 T4327 T4333 themeOf IκB-α,degradation
R3968 T4328 T4334 themeOf p65,increased
R3971 T4332 T4335 themeOf degradation,induced
R3972 T4333 T4336 themeOf degradation,induced
R3976 T4340 T4341 themeOf IκB-α,synthesis
R3977 T4342 T4344 themeOf IκB-α,binds
R3978 T4343 T4344 themeOf Tat,binds
R3980 T4345 T4350 themeOf Tat,counteracts
R3981 T4346 T4350 themeOf NF-κB,counteracts
R3982 T4347 T4351 themeOf IκB-α,interaction
R3983 T4347 T4354 causeOf IκB-α,enhances
R3984 T4348 T4352 themeOf p65,interaction
R3985 T4348 T4355 causeOf p65,enhances
R3986 T4349 T4353 themeOf NF-κB complex,binding
R4883 T5641 T5643 themeOf luciferase,co-transfected
R4884 T5642 T5644 themeOf pκBluc,co-transfected
R4885 T5643 T5645 themeOf co-transfected,co-transfected
R4886 T5644 T5646 themeOf co-transfected,co-transfected
R5178 T6026 T6031 themeOf p65,interference
R5179 T6027 T6032 themeOf IκB-α,interference
R5678 T6672 T6673 themeOf NF-κB DNA,binding
R5679 T6682 T6689 themeOf p65,Binding
R5680 T6683 T6690 themeOf p50,Binding
R5681 T6684 T6691 themeOf FLAG,Binding
R5682 T6685 T6692 themeOf Tat,Binding
R5683 T6686 T6689 themeOf NF-κB,Binding
R5684 T6686 T6690 themeOf NF-κB,Binding
R5685 T6686 T6691 themeOf NF-κB,Binding
R5686 T6686 T6692 themeOf NF-κB,Binding
R5687 T6686 T6688 partOf NF-κB,oligonucleotide
R5688 T6688 T6689 Site oligonucleotide,Binding
R5689 T6688 T6690 Site oligonucleotide,Binding
R5690 T6688 T6691 Site oligonucleotide,Binding
R5691 T6688 T6692 Site oligonucleotide,Binding
R5822 T6859 T6865 themeOf HA,expressed
R5823 T6860 T6866 themeOf IκB-α,expressed
R5824 T6861 T6867 themeOf p65,expressed
R5825 T6862 T6868 themeOf Tat,expressed
R5826 T6863 T6869 themeOf T7 promoter,expressed
R6265 T7483 T7484 themeOf GAPDH mRNA,expression
R6266 T7485 T7486 themeOf Ct GAPDH,expression
R6778 T8138 T8139 themeOf 1× Complete Protease,Inhibitor
R9171 T11251 T11252 themeOf NF-κB,induced
R9172 T11177 T11181 causeOf Tat,enhances
R9173 T11178 T11181 themeOf NF-κB,enhances
R9174 T11179 T11182 themeOf IκB-α,hijacking
R9175 T11256 T11257 themeOf NF-κB,activation
R9176 T11183 T11185 themeOf NF-κB,activation
R9177 T11184 T11186 themeOf Tat,expression
R9178 T11186 T11187 themeOf expression,modulating
R9179 T11258 T11261 themeOf p65 DNA,binding
R9180 T11190 T11192 themeOf Tat,expression
R9181 T11259 T11262 causeOf Tat,enhanced
R9182 T11191 T11194 themeOf Tat,transfected
R9183 T11192 T11193 themeOf expression,increased
R9184 T11260 T11263 themeOf IκB-α,affected
R9185 T11194 T11195 themeOf transfected,transfected
R9186 T11261 T11262 themeOf binding,enhanced
R9187 T11196 T11199 themeOf luciferase,expression
R9188 T11197 T11201 themeOf Tat,transfected
R9189 T11267 T11268 themeOf Tat,negative
R9190 T11199 T11200 themeOf expression,induced
R9191 T11201 T11202 themeOf transfected,transfected
R9192 T11203 T11209 themeOf NF-κB,increase
R9193 T11203 T11212 themeOf NF-κB,post-infection
R9194 T11204 T11210 themeOf p65,binding
R9195 T11204 T11211 themeOf p65,binding
R9196 T11205 T11211 themeOf p50,binding
R9197 T11206 T11213 themeOf Tat,positive
R9198 T11207 T11214 themeOf p65 DNA,binding
R9199 T11208 T11216 themeOf Tat,presence
R9200 T11269 T11272 themeOf Tat,bound
R9201 T11214 T11215 themeOf binding,elevated
R9202 T11269 T11273 themeOf Tat,bound
R9203 T11269 T11274 themeOf Tat,binding
R9204 T11216 T11217 themeOf presence,elevated
R9205 T11270 T11273 themeOf NF-κB oligonucleotide,bound
R9206 T11218 T11221 themeOf IκB-α,degraded
R9207 T11219 T11222 themeOf Tat,positive
R9208 T11219 T11223 themeOf Tat,negative
R9209 T11271 T11276 themeOf NF-κB complex,component
R9210 T11220 T11224 themeOf Tat,negative
R9211 T11271 T11277 themeOf NF-κB complex,bound
R9212 T11274 T11275 themeOf binding,increased
R9213 T11225 T11226 themeOf IKK,induced
R9214 T11225 T11227 themeOf IKK,decreased
R9215 T11228 T11233 themeOf NF-κB,degradation/re-synthesis
R9216 T11229 T11232 themeOf IKK,activation
R9217 T11278 T11280 themeOf IκB-α,Degradation
R9218 T11230 T11234 themeOf IκB-α,degradation/re-synthesis
R9219 T11233 T11235 themeOf degradation/re-synthesis,activation
R9220 T11234 T11236 themeOf degradation/re-synthesis,activation
R9221 T11279 T11282 themeOf Tat,positive
R9222 T11237 T11244 themeOf NF-κB,activation
R9223 T11238 T11245 themeOf IKK,activation
R9224 T11280 T11281 themeOf Degradation,induced
R9225 T11239 T11246 themeOf IκB-α,degradation
R9226 T11283 T11284 themeOf IKK,activation
R9227 T11243 T11247 themeOf IκB-α,synthesis
R9228 T11246 T11248 themeOf degradation,activation
R9229 T11285 T11289 causeOf Tat,enhanced
R9230 T11247 T11249 themeOf synthesis,elevated
R9231 T11286 T11289 themeOf NF-κB,enhanced
R9232 T11287 T11290 themeOf IKK,affecting
R9233 T11288 T11291 themeOf IκB-α,affecting
R9234 T11292 T11298 themeOf Tat,binds
R9235 T11292 T11299 themeOf Tat,binds
R9236 T11293 T11298 themeOf ankyrin,binds
R9237 T11294 T11299 themeOf IκB-α,binds
R9238 T11295 T11300 themeOf Tat,counteracted
R9239 T11295 T11301 themeOf Tat,counteracted
R9240 T11296 T11302 themeOf IκB-α,generation
R9241 T11297 T11301 themeOf NF-κB complex,counteracted
R9242 T11297 T11303 themeOf NF-κB complex,generation
R9243 T11304 T11307 themeOf IκB-α,association
R9244 T11305 T11307 themeOf p65,association
R9245 T11306 T11308 themeOf IκB-α,synthesis
R9246 T11309 T11318 themeOf IκB-α,Coimmunoprecipitation
R9247 T11310 T11318 themeOf p65,Coimmunoprecipitation
R9248 T11311 T11319 themeOf Tat,negative
R9249 T11312 T11320 themeOf Tat,positive
R9250 T11313 T11321 themeOf Tat,coimmunoprecipitated
R9251 T11313 T11322 themeOf Tat,coimmunoprecipitated
R9252 T11314 T11322 themeOf IκB-α,coimmunoprecipitated
R9253 T11315 T11323 themeOf Tat,competed
R9254 T11316 T11324 themeOf IκB-α,binding
R9255 T11317 T11324 themeOf p65,binding
R10555 T13000 T13003 themeOf Tat,counteracts
R10556 T13001 T13004 themeOf IκB-α,inhibition
R10557 T13002 T13005 themeOf p65,inhibition
R10558 T13006 T13008 themeOf Tat,interaction
R10559 T13007 T13008 themeOf IκB-α,interaction
R10560 T13013 T13015 themeOf Tat,binding
R10561 T13014 T13015 themeOf IκB-α,binding
R10562 T13016 T13024 themeOf Tat,associating
R10563 T13016 T13030 causeOf Tat,competed
R10564 T13017 T13024 themeOf IκB-α,associating
R10565 T13018 T13025 themeOf IκB-α,binding
R10566 T13019 T13025 themeOf p65,binding
R10567 T13020 T13028 themeOf Tat R,associate
R10568 T13021 T13026 themeOf IκB-α,binding
R10569 T13022 T13027 themeOf IκB-α,associate
R10570 T13022 T13028 themeOf IκB-α,associate
R10571 T13023 T13029 themeOf IκB-α,binding
R10572 T13025 T13030 themeOf binding,competed
R10573 T13026 T13031 themeOf binding,lacked
R10574 T13029 T13032 themeOf binding,compete
R10575 T13033 T13040 themeOf Tat,counteracted
R10576 T13035 T13041 themeOf p65,binding
R10577 T13041 T13042 themeOf binding,inhibition
R10578 T13043 T13046 themeOf p65 DNA,binding
R10579 T13043 T13048 themeOf p65 DNA,restored
R10580 T13044 T13047 causeOf IκB-α,inhibited
R10581 T13045 T13048 causeOf Tat R,restored
R10582 T13045 T13049 causeOf Tat R,restored
R10583 T13046 T13047 themeOf binding,inhibited
R10584 T13046 T13049 themeOf binding,restored
R10585 T13050 T13061 causeOf Tat,effect
R10586 T13051 T13058 themeOf IκB-α,repression
R10587 T13055 T13059 themeOf p65,expression
R10588 T13056 T13060 themeOf IκB-α,expression
R10589 T13058 T13061 themeOf repression,effect
R10590 T13062 T13067 causeOf IκB-α,inhibited
R10591 T13063 T13068 causeOf p65,dependent
R10592 T13064 T13066 themeOf luciferase gene,expression
R10593 T13066 T13067 themeOf expression,inhibited
R10594 T13066 T13068 themeOf expression,dependent
R10595 T13069 T13074 themeOf Tat,counteracts
R10596 T13070 T13075 themeOf IκB-α,repression
R10597 T13070 T13076 themeOf IκB-α,binding
R10598 T13071 T13076 themeOf p65 DNA,binding
R10599 T13072 T13077 themeOf IκB-α,associating
R10600 T13073 T13078 themeOf p65,binding
R10601 T13076 T13079 themeOf binding,repression
R11844 T14760 T14763 causeOf Tat,increases
R11845 T14761 T14762 themeOf p65,binding
R11846 T14762 T14763 themeOf binding,increases
R11847 T14764 T14766 themeOf Tat,interacted
R11848 T14765 T14766 themeOf p65,interacted
R11849 T14767 T14772 themeOf HA,expression
R11850 T14768 T14773 themeOf p65,expression
R11851 T14769 T14774 themeOf FLAG,expression
R11852 T14770 T14775 themeOf Tat,expression
R11853 T14776 T14781 themeOf p65 protein,coimmunoprecipitated
R11854 T14777 T14780 themeOf wild-type Tat,coimmunoprecipitated
R11855 T14777 T14781 themeOf wild-type Tat,coimmunoprecipitated
R11856 T14780 T14782 themeOf coimmunoprecipitated,decrease
R11857 T14781 T14783 themeOf coimmunoprecipitated,decrease
R11858 T14785 T14788 themeOf p65,binding
R11859 T14785 T14789 themeOf p65,binding
R11860 T14786 T14789 themeOf mutants Tat T,binding
R11861 T14786 T14790 themeOf mutants Tat T,binding
R11862 T14786 T14792 themeOf mutants Tat T,binding
R11863 T14787 T14791 themeOf Tat C,binding
R11864 T14787 T14792 themeOf Tat C,binding
R11865 T14793 T14795 themeOf Tat,associated
R11866 T14793 T14796 themeOf Tat,interaction
R11867 T14794 T14795 themeOf p65,associated
R11868 T14797 T14800 themeOf p65 domain,binding
R11869 T14798 T14800 themeOf Tat,binding
R11870 T14800 T14801 themeOf binding,required
R11871 T14802 T14804 themeOf p65,interaction
R11872 T14803 T14804 themeOf Tat,interaction
R11873 T14811 T14813 themeOf p65,binding
R11874 T14812 T14814 themeOf p65,binding
R11875 T14813 T14815 themeOf binding,increased
R11876 T14816 T14820 themeOf p65,binding
R11877 T14818 T14822 causeOf Tat,enhanced
R11878 T14819 T14821 themeOf p65,binding
R11879 T14821 T14822 themeOf binding,enhanced
R14004 T17406 T17408 themeOf p65,recruitment
R14005 T17407 T17408 themeOf IκB-α displacement,recruitment
R14006 T17408 T17409 themeOf recruitment,promotes
R14007 T17416 T17427 causeOf Tat,increased
R14008 T17416 T17428 causeOf Tat,increased
R14009 T17416 T17429 causeOf Tat,increased
R14010 T17416 T17430 causeOf Tat,increased
R14011 T17416 T17431 causeOf Tat,increased
R14012 T17417 T17422 themeOf MIP-1α,expression
R14013 T17418 T17423 themeOf CSF3,expression
R14014 T17419 T17424 themeOf LTA,expression
R14015 T17420 T17425 themeOf NFKBIA,expression
R14016 T17421 T17426 themeOf TLR2,expression
R14017 T17422 T17427 themeOf expression,increased
R14018 T17423 T17428 themeOf expression,increased
R14019 T17424 T17429 themeOf expression,increased
R14020 T17425 T17430 themeOf expression,increased
R14021 T17426 T17431 themeOf expression,increased
R14022 T17435 T17436 themeOf Tat,activation
R14023 T17437 T17441 themeOf NF-κB,expression
R14024 T17438 T17442 themeOf GAPDH,expression
R14025 T17439 T17443 themeOf ACTB,expression
R14026 T17440 T17444 causeOf Tat mutants,unaffected
R14027 T17440 T17445 causeOf Tat mutants,unaffected
R14028 T17440 T17446 causeOf Tat mutants,unaffected
R14029 T17441 T17444 themeOf expression,unaffected
R14030 T17442 T17445 themeOf expression,unaffected
R14031 T17443 T17446 themeOf expression,unaffected
R14032 T17447 T17453 causeOf Tat,enhance
R14033 T17448 T17453 themeOf NF-κB,enhance
R14034 T17451 T17454 themeOf p65,interaction
R14035 T17452 T17455 themeOf IκB-α,interaction
R14036 T17458 T17461 themeOf MIP-1α,expression
R14037 T17459 T17463 themeOf MIP-1α,production
R14038 T17460 T17464 causeOf Tat,induced
R14039 T17461 T17462 themeOf expression,increased
R14040 T17463 T17464 themeOf production,induced
R14041 T17465 T17466 themeOf MIP-1α,regulation
R14042 T17467 T17472 themeOf NF-κB enhancers,predicted
R14043 T17468 T17474 themeOf MIP-1α gene,region
R14044 T17469 T17473 themeOf NF-κB1,predicted
R14045 T17478 T17482 themeOf NF-κB,inducer
R14046 T17479 T17483 themeOf MIP-1α,expression
R14047 T17480 T17484 themeOf p65,occupancy
R14048 T17481 T17485 themeOf NF-κB sites,occupancy
R14049 T17486 T17494 causeOf TNF-α,induced
R14050 T17486 T17497 causeOf TNF-α,activated
R14051 T17487 T17493 themeOf MIP-1α,expression
R14052 T17488 T17494 themeOf p65 recruitment,induced
R14053 T17491 T17495 themeOf NF-κB2,occupancy
R14054 T17492 T17496 themeOf S3C,occupancy
R14055 T17493 T17497 themeOf expression,activated
R14056 T17495 T17498 themeOf occupancy,affecting
R14057 T17496 T17499 themeOf occupancy,affecting
R14058 T17505 T17510 themeOf NF-κB1 site,effective
R14059 T17512 T17523 causeOf Tat,increased
R14060 T17513 T17522 themeOf p65,recruitment
R14061 T17514 T17522 themeOf NF-κB,recruitment
R14062 T17514 T17521 partOf NF-κB,enhancers
R14063 T17515 T17521 partOf CSF3,enhancers
R14064 T17516 T17521 partOf LTA,enhancers
R14065 T17517 T17521 partOf NFKBIA,enhancers
R14066 T17518 T17521 partOf TLR2,enhancers
R14067 T17521 T17522 Site enhancers,recruitment
R14068 T17522 T17523 themeOf recruitment,increased
R14069 T17529 T17532 themeOf following p65 RNA,binding
R14070 T17530 T17533 themeOf Tat,interaction
R14071 T17531 T17533 themeOf p65,interaction
R14072 T17532 T17534 themeOf binding,loss
R14073 T17535 T17542 themeOf IκB-α,findings
R14074 T17535 T17543 themeOf IκB-α,findings
R14075 T17536 T17543 themeOf NF-κB enhancers,findings
R14076 T17537 T17544 themeOf Tat,absence
R15343 T19169 T19171 themeOf MIP-1α,activation
R15344 T19170 T19172 themeOf IκB-α,interacting
R15345 T19171 T19173 themeOf activation,promotes
R15346 T19172 T19173 causeOf interacting,promotes
R15347 T19174 T19178 causeOf Tat,affected
R15348 T19176 T19177 themeOf MIP-1α,expression
R15349 T19177 T19178 themeOf expression,affected
R15350 T19179 T19181 themeOf Tat protein,detect
R15351 T19183 T19185 themeOf Tat,expression
R15352 T19185 T19186 themeOf expression,modulate
R15353 T19187 T19190 themeOf Tat,expression
R15354 T19188 T19191 themeOf p24,expression
R15355 T19189 T19192 themeOf Tat,transfected
R15356 T19192 T19193 themeOf transfected,transfected
R15357 T19194 T19199 themeOf NF-κB,induced
R15358 T19194 T19202 themeOf NF-κB,increased
R15359 T19196 T19200 themeOf Tat,negative
R15360 T19197 T19201 themeOf Tat,negative
R15361 T19198 T19203 themeOf Tat,positive
R15362 T19204 T19207 themeOf IκB-α,Degradation
R15363 T19208 T19210 themeOf IKK,induced
R15364 T19211 T19213 themeOf NF-κB,activation
R15365 T19214 T19219 themeOf Tat,coimmunoprecipitated
R15366 T19214 T19222 causeOf Tat,activated
R15367 T19215 T19219 themeOf IκB-α,coimmunoprecipitated
R15368 T19216 T19220 themeOf MIP-1α,expression
R15369 T19218 T19221 themeOf Tat,interference
R15370 T19220 T19222 themeOf expression,activated
R15371 T19227 T19228 themeOf p65,occupancy
R15372 T19228 T19229 themeOf occupancy,abolished
R15373 T19230 T19236 themeOf IκB-α,associated
R15374 T19231 T19237 themeOf p65,associated
R15375 T19233 T19238 themeOf MIP-1α,expression
R15376 T19235 T19239 themeOf p65,recruitment
R15377 T19238 T19240 themeOf expression,activation
R15378 T19240 T19241 themeOf activation,induced
R18847 T23606 T23608 themeOf NF-κB,activation
R18855 T23609 T23619 themeOf Tat,interacted
R18861 T23609 T23620 themeOf Tat,interacted
R18862 T23609 T23624 causeOf Tat,enhanced
R18863 T23609 T23625 causeOf Tat,enhanced
R18866 T23610 T23617 themeOf p65 subunit,activity
R18870 T23611 T23618 themeOf NF-κB,activity
R18872 T23612 T23620 themeOf IκB-α repressor,interacted
R18875 T23613 T23621 causeOf Tat,activate
R18877 T23613 T23626 causeOf Tat,activate
R18881 T23613 T23627 causeOf Tat,activate
R18884 T23614 T23621 themeOf NF-κB,activate
R18887 T23615 T23622 themeOf IκB-α,interaction
R18888 T23616 T23623 themeOf p65,interaction
R18891 T23617 T23624 themeOf activity,enhanced
R18895 T23618 T23625 themeOf activity,enhanced
R18896 T23622 T23626 themeOf interaction,activate
R18911 T23623 T23627 themeOf interaction,activate
R18913 T23629 T23630 themeOf Tat,expression
R18915 T23630 T23631 themeOf expression,silence
R18916 T23633 T23637 themeOf NF-κB,activation
R18917 T23634 T23638 themeOf IKK,activation
R18918 T23635 T23639 themeOf IκB-α,degradation
R18919 T23725 T23734 themeOf Tat,activation
R18920 T23726 T23735 themeOf NF-κB,activation
R18921 T23639 T23640 themeOf degradation,activation
R18922 T23727 T23741 causeOf Tat mutants,up-regulated
R18923 T23641 T23646 themeOf IKK,synthesis
R18924 T23642 T23647 themeOf IκB-α,synthesis
R18925 T23643 T23648 themeOf NF-κB,elevated
R18926 T23727 T23742 causeOf Tat mutants,up-regulated
R18927 T23727 T23743 causeOf Tat mutants,up-regulated
R18928 T23645 T23649 themeOf Tat gene,silencing
R18929 T23727 T23744 causeOf Tat mutants,up-regulated
R18930 T23727 T23745 causeOf Tat mutants,up-regulated
R18931 T23729 T23736 themeOf MIP-1α,expression
R18932 T23650 T23654 causeOf Tat,enhanced
R18933 T23651 T23654 themeOf NF-κB,enhanced
R18934 T23652 T23655 themeOf IKK,affecting
R18935 T23730 T23737 themeOf CSF3,expression
R18936 T23653 T23656 themeOf IκB-α,affecting
R18937 T23731 T23738 themeOf LTA,expression
R18938 T23657 T23662 themeOf NF-κB,activation
R18939 T23732 T23739 themeOf NFKBIA,expression
R18940 T23733 T23740 themeOf TLR2,expression
R18941 T23736 T23741 themeOf expression,up-regulated
R18942 T23658 T23663 themeOf Tat,transfected
R18943 T23737 T23742 themeOf expression,up-regulated
R18944 T23738 T23743 themeOf expression,up-regulated
R18945 T23663 T23664 themeOf transfected,transfected
R18946 T23739 T23744 themeOf expression,up-regulated
R18947 T23665 T23669 causeOf Tat,activation
R18948 T23666 T23669 themeOf NF-κB,activation
R18949 T23740 T23745 themeOf expression,up-regulated
R18950 T23667 T23670 themeOf IκB-α,association
R18951 T23668 T23671 themeOf IκB-α/p65 complex,generation
R18952 T23672 T23677 themeOf Tat,competed
R18953 T23746 T23750 themeOf Tat,recovered
R18954 T23672 T23681 causeOf Tat,prevented
R18955 T23672 T23682 causeOf Tat,prevented
R18956 T23673 T23678 themeOf IκB-α,binding
R18957 T23674 T23678 themeOf p65,binding
R18958 T23675 T23679 themeOf IκB-α,repression
R18959 T23676 T23680 themeOf p65,repression
R18960 T23679 T23681 themeOf repression,prevented
R18961 T23680 T23682 themeOf repression,prevented
R18962 T23746 T23751 causeOf Tat,increased
R18963 T23683 T23691 themeOf NF-κB,activation
R18964 T23747 T23749 themeOf p65,recruitment
R18965 T23684 T23692 themeOf Tat,associated
R18966 T23685 T23692 themeOf p65,associated
R18967 T23748 T23749 themeOf NF-κB enhancers,recruitment
R18968 T23688 T23693 themeOf p65,binding
R18969 T23749 T23751 themeOf recruitment,increased
R18970 T23689 T23694 themeOf Tat,association
R18971 T23752 T23760 causeOf p65,abolished
R18972 T23696 T23698 themeOf p65,binding
R18973 T23753 T23758 themeOf Tat,occupancy
R18974 T23697 T23699 themeOf NF-κB,activation
R18975 T23754 T23758 causeOf NF-κB enhancers,occupancy
R18976 T23701 T23704 themeOf ankyrin,binding
R18977 T23701 T23706 themeOf ankyrin,binding
R18978 T23702 T23705 themeOf IκB-α,binding
R18979 T23702 T23706 themeOf IκB-α,binding
R18980 T23755 T23759 themeOf Tat,binding
R18981 T23703 T23707 themeOf IκB-α,inhibition
R18982 T23704 T23708 themeOf binding,required
R18983 T23705 T23709 themeOf binding,required
R18984 T23756 T23759 themeOf NF-κB sites,binding
R18985 T23706 T23710 themeOf binding,required
R18986 T23758 T23760 themeOf occupancy,abolished
R18987 T23712 T23717 themeOf NF-κB,regulation
R18988 T23761 T23765 causeOf Tat,displaced
R18989 T23713 T23718 themeOf IκB-α repressor,hijacking
R18990 T23714 T23719 themeOf p65,shielding
R18991 T23715 T23720 themeOf IκB-α,shielding
R18992 T23716 T23721 themeOf p65,binding
R18993 T23717 T23722 themeOf regulation,abolished
R18994 T23761 T23767 causeOf Tat,increased
R18995 T23717 T23723 themeOf regulation,abolished
R18996 T23761 T23768 causeOf Tat,displaced
R18997 T23719 T23722 causeOf shielding,abolished
R18998 T23762 T23765 themeOf p65,displaced
R18999 T23720 T23723 causeOf shielding,abolished
R19000 T23721 T23724 themeOf binding,enforcing
R19001 T23762 T23766 themeOf p65,binding
R19002 T23763 T23766 themeOf IκB-α,binding
R19003 T23764 T23767 themeOf p65 DNA,increased
R19004 T23766 T23768 themeOf binding,displaced
R19005 T23809 T23819 themeOf Tat,coimmunoprecipitation
R19006 T23809 T23820 themeOf Tat,coimmunoprecipitation
R19007 T23810 T23819 themeOf IκB-α,coimmunoprecipitation
R19008 T23811 T23820 themeOf p65,coimmunoprecipitation
R19009 T23812 T23821 themeOf MIP-1α,expression
R19010 T23769 T23778 causeOf Tat,increased
R19011 T23813 T23822 themeOf Tat,expression
R19012 T23814 T23823 themeOf p65,expression
R19013 T23815 T23824 themeOf Tat,occupancy
R19014 T23816 T23824 themeOf MIP-1α,occupancy
R19015 T23770 T23775 themeOf p65,recruitment
R19016 T23818 T23825 themeOf p65,recruitment
R19017 T23772 T23776 themeOf p65,associating
R19018 T23821 T23826 themeOf expression,induction
R19019 T23822 T23827 themeOf expression,induction
R19020 T23823 T23828 themeOf expression,induction
R19021 T23773 T23777 themeOf p65,assembly
R19022 T23774 T23777 themeOf IκB-α,assembly
R19023 T23775 T23778 themeOf recruitment,increased
R19024 T23779 T23783 themeOf IκB-α,associated
R19025 T23832 T23836 themeOf NF-κB,control
R19026 T23833 T23837 themeOf IL-6,hyper-expressed
R19027 T23834 T23838 themeOf TNF-α,hyper-expressed
R19028 T23835 T23839 themeOf MIP-1α,hyper-expressed
R19029 T23781 T23783 themeOf Tat,associated
R19030 T23782 T23784 themeOf Tat,presence
R19031 T23786 T23792 themeOf IκB-α,associated
R19032 T23786 T23793 themeOf IκB-α,associated
R19033 T23787 T23792 themeOf hystone deacetylases,associated
R19034 T23851 T23852 themeOf NF-κB,inhibition
R19035 T23788 T23793 themeOf hes1 promoter,associated
R19036 T23853 T23856 themeOf NF-κB,inhibitors
R19037 T23854 T23857 themeOf IKK,inhibitors
R19038 T23789 T23794 themeOf TNF-α,stimulation
R19039 T23858 T23863 causeOf Tat,activates
R19040 T23858 T23866 causeOf Tat,activates
R19041 T23858 T23867 causeOf Tat,activates
R19042 T23790 T23795 themeOf histone,acetylation
R19043 T23859 T23863 themeOf NF-κB,activates
R19044 T23860 T23864 themeOf IκB-α,interaction
R19045 T23861 T23865 themeOf p65,interaction
R19046 T23795 T23796 themeOf acetylation,activation
R19047 T23864 T23866 themeOf interaction,activates
R19048 T23865 T23867 themeOf interaction,activates
R19049 T23796 T23797 themeOf activation,causing
R19050 T23799 T23801 causeOf Tat,removing
R19051 T23800 T23801 themeOf IκB-α,removing
R19336 T24301 T24303 themeOf Tat,expression
R19337 T24308 T24312 themeOf p65,expression
R19338 T24309 T24313 themeOf IκB-α,expression
R20005 T25074 T25076 themeOf IκB-α,associating
R20006 T25075 T25077 themeOf NF-κB,repression
R20904 T26369 T26372 themeOf p65,relieves
R20905 T26370 T26371 themeOf IκB-α,inhibition
R20906 T26371 T26372 causeOf inhibition,relieves
R20907 T26390 T26391 themeOf p65 DNA,binding
R20908 T26405 T26406 themeOf pκBLuc plasmid alone,transfection
R21307 T27133 T27135 themeOf Tat,associates
R21308 T27150 T27153 themeOf mutant HA-p65 proteins,immunoprecipitated
R21309 T27151 T27152 themeOf anti-HA antibody,immunoprecipitated
R21310 T27151 T27153 themeOf anti-HA antibody,immunoprecipitated
R22103 T28182 T28185 themeOf NF-κB enhancers,occupying
R22104 T28183 T28186 themeOf p65,recruitment
R22105 T28184 T28186 themeOf IκB-α,recruitment
R22106 T28186 T28187 themeOf recruitment,promoting
R22107 T28192 T28194 themeOf p65 RNA,interference
R22108 T28195 T28197 themeOf MIP-1α,expression
R22109 T28196 T28198 themeOf GAPDH,expression
R22110 T28197 T28199 themeOf expression,evaluate
R22111 T28198 T28200 themeOf expression,evaluate
R22640 T29012 T29015 themeOf MIP-1α,expression
R22641 T29013 T29016 themeOf IκB-α,interaction
R22642 T29015 T29017 themeOf expression,enhances
R22643 T29016 T29017 causeOf interaction,enhances
R22644 T29020 T29022 themeOf Tat,expression
R22645 T29023 T29027 themeOf p65,binding
R22646 T29024 T29027 themeOf NF-κB,binding
R22647 T29024 T29026 partOf NF-κB,oligonucleotide
R22648 T29026 T29027 Site oligonucleotide,binding
R22649 T29029 T29030 themeOf anti-IκB-α antibody,using
R22650 T29039 T29040 themeOf MIP-1α,expression
R22946 T29392 T29394 themeOf MIP-1α,activation
R22947 T29395 T29399 themeOf Tat,absence
R22948 T29396 T29400 causeOf IκB-α,occupies
R22949 T29396 T29401 themeOf IκB-α,interacts
R22950 T29397 T29400 themeOf NF-κB enhancer,occupies
R22951 T29402 T29413 causeOf Tat,activates
R22952 T29403 T29409 themeOf MIP-1α,expression
R22953 T29404 T29410 themeOf IκB-α repressor,removing
R22954 T29406 T29412 themeOf p65,complex
R22955 T29407 T29412 themeOf NF-κB,complex
R22956 T29408 T29411 themeOf NF-κB enhancer,binding
R22957 T29409 T29413 themeOf expression,activates
R22958 T29411 T29414 themeOf binding,increasing

test2

Id Subject Object Predicate Lexical cue Negation Speculation
T78 1027-1030 Protein denotes p65
T79 1036-1048 Binding denotes displacement
T80 1052-1057 Protein denotes IκB-α
T81 1121-1125 Protein denotes CSF3
T82 1127-1130 Protein denotes LTA
T83 1132-1138 Protein denotes NFKBIA
T84 1143-1147 Protein denotes TLR2
T85 1220-1231 Binding denotes interaction
T86 1235-1238 Protein denotes Tat
T87 1244-1249 Protein denotes IκB-α
T88 1254-1257 Protein denotes p65
T1138 1543-1547 Protein denotes RelA
T1139 1548-1551 Protein denotes p65
T1140 1553-1558 Protein denotes c-Rel
T1141 1560-1564 Protein denotes RelB
T1142 1566-1569 Protein denotes p50
T1143 1574-1577 Protein denotes p52
T1144 1623-1642 Entity denotes Rel homology domain
T1145 1690-1697 Binding denotes binding
T1146 1867-1870 Protein denotes p65
T1147 1872-1876 Protein denotes RelB
T1148 1881-1886 Protein denotes c-Rel
T1149 1974-1981 Binding denotes binding
T1150 2249-2254 Protein denotes IκB-α
T1151 2301-2315 Phosphorylation denotes phosphorylated
T1152 2326-2331 Entity denotes Ser32
T1153 2336-2341 Entity denotes Ser36
T1154 2364-2377 Positive_regulation denotes ubiquitylated
T1155 2381-2386 Entity denotes Lys21
T1156 2391-2396 Entity denotes Lys22
T1157 2403-2411 Protein_catabolism denotes degraded
T1158 2461-2469 Positive_regulation denotes enhanced
T1159 2473-2488 Phosphorylation denotes phosphorylation
T1160 2492-2495 Protein denotes p65
T1161 2499-2505 Entity denotes Ser276
T1162 2517-2521 Protein denotes MSK1
T1163 2539-2543 Protein denotes PKCζ
T1164 2552-2558 Entity denotes Ser536
T1165 2562-2566 Protein denotes IKKα
T1166 2576-2587 Phosphorylation denotes Acetylation
T1167 2591-2594 Protein denotes p65
T1168 2598-2604 Entity denotes Lys218
T1169 2616-2625 Positive_regulation denotes increases
T1170 2634-2641 Binding denotes binding
T1171 2646-2653 Negative_regulation denotes impairs
T1172 2658-2669 Binding denotes association
T1173 2675-2680 Protein denotes IκB-α
T1174 2708-2716 Positive_regulation denotes enhances
T1175 2721-2724 Protein denotes p65
T1176 2725-2740 Transcription denotes transcriptional
T1177 2903-2908 Protein denotes IκB-α
T1178 2939-2942 Protein denotes A20
T1179 2952-2965 Negative_regulation denotes Deacetylation
T1180 2969-2972 Protein denotes p65
T1181 2976-2997 Protein denotes histone deacetylase-3
T1182 3001-3006 Protein denotes SIRT1
T1183 3011-3022 Phosphorylation denotes acetylation
T1184 3026-3029 Protein denotes p65
T1185 3033-3039 Entity denotes Lys122
T1186 3044-3050 Entity denotes Lys123
T1187 3825-3830 Protein denotes gp120
T1188 3849-3852 Protein denotes CD4
T1189 3883-3893 Positive_regulation denotes activation
T1190 3910-3922 Protein denotes procaspase 8
T1191 3982-3985 Protein denotes Tat
T1192 3994-4003 Binding denotes interacts
T1193 4079-4082 Protein denotes Tat
T1194 4083-4088 Binding denotes binds
T1195 4231-4254 Protein denotes tumor necrosis factor β
T1196 4256-4260 Protein denotes TNFβ
T1197 4271-4284 Protein denotes interleukin-6
T1198 4286-4290 Protein denotes IL-6
T1199 4337-4340 Protein denotes Tat
T1200 4399-4410 Binding denotes interacting
T1201 4459-4462 Protein denotes Sp1
T1202 4469-4474 Protein denotes TFIID
T1203 4481-4486 Protein denotes E2F-4
T1204 4493-4499 Protein denotes C/EBPβ
T1205 4506-4515 Protein denotes cyclin T1
T1206 4516-4520 Protein denotes CDK9
T1207 4564-4568 Protein denotes p300
T1208 4569-4572 Protein denotes CBP
T1209 4577-4582 Protein denotes P/CAF
T1210 4633-4636 Protein denotes Tat
T1211 4671-4678 Binding denotes binding
T1212 4722-4739 Protein denotes Flk1/KDR receptor
T1213 4858-4867 Gene_expression denotes expressed
T1214 4872-4875 Protein denotes Tat
T1215 4940-4943 Protein denotes Tat
T1216 4944-4951 Positive_regulation denotes induced
T1217 4985-4996 Protein_catabolism denotes degradation
T1218 5000-5005 Protein denotes IκB-α
T1219 5016-5025 Positive_regulation denotes increased
T1220 5030-5033 Protein denotes p65
T1221 5034-5049 Transcription denotes transcriptional
T1222 5062-5072 Negative_regulation denotes inhibiting
T1223 5077-5083 Protein denotes SIRT-1
T1224 5084-5092 Positive_regulation denotes mediated
T1225 5093-5106 Negative_regulation denotes deacetylation
T1226 5110-5113 Protein denotes p65
T1227 5157-5160 Protein denotes Tat
T1228 5244-5247 Protein denotes Tat
T1229 5310-5319 Regulation denotes dependent
T1230 5331-5340 Gene_expression denotes synthesis
T1231 5344-5349 Protein denotes IκB-α
T1232 5384-5389 Protein denotes IκB-α
T1233 5390-5395 Binding denotes binds
T1234 5399-5402 Protein denotes Tat
T1235 5407-5415 Positive_regulation denotes promotes
T1236 5420-5427 Entity denotes nuclear
T1237 5428-5434 Localization denotes export
T1238 5502-5505 Protein denotes Tat
T1239 5571-5582 Binding denotes interaction
T1240 5588-5593 Protein denotes IκB-α
T1241 5598-5601 Protein denotes p65
T1242 5626-5633 Binding denotes binding
T4375 5876-5886 Protein denotes 3xHA-IκB-α
T4376 5900-5903 Protein denotes Tat
T4377 5917-5933 Protein denotes Tat C(22,25,27)A
T4378 5947-5972 Protein denotes Tat R(49,52,53,55,56,57)A
T4379 5982-5985 Protein denotes Tat
T4380 5995-6011 Protein denotes Tat C(22,25,27)A
T4381 6024-6049 Protein denotes Tat R(49,52,53,55,56,57)A
T4382 6121-6124 Protein denotes env
T4383 6241-6246 Protein denotes β-Gal
T4384 6316-6324 Protein denotes 3xHA-p65
T4385 6334-6344 Protein denotes 3xHA-p65ΔC
T4386 6361-6371 Protein denotes 3xHA-p65ΔN
T4387 6394-6409 Protein denotes Tat T,N(23,24)A
T4388 6423-6436 Protein denotes Tat K(50,51)A
T4389 6446-6461 Protein denotes Tat T,N(23,24)A
T4390 6471-6484 Protein denotes Tat K(50,51)A
T4391 6501-6504 Protein denotes Tat
T4875 6598-6608 Protein denotes luciferase
T4876 6621-6624 Protein denotes p50
T4877 6627-6630 Protein denotes p65
T4878 7015-7018 Protein denotes p50
T4879 7021-7024 Protein denotes p65
T4880 7428-7451 Protein denotes tumor necrosis factor-α
T4881 7453-7458 Protein denotes TNF-α
T4882 7572-7582 Protein denotes luciferase
T4883 7595-7600 Protein denotes β-Gal
T4884 7755-7765 Protein denotes Luciferase
T4885 7808-7818 Protein denotes luciferase
T4886 7823-7838 Protein denotes β-galactosidase
T4887 7993-8003 Protein denotes luciferase
T4888 8016-8031 Protein denotes β-galactosidase
T4889 8045-8054 Gene_expression denotes expressed
T5661 8544-8559 Protein denotes siRNA Tat sense
T5662 8587-8606 Protein denotes siRNA Tat antisense
T5663 8731-8743 Negative_regulation denotes interference
T5664 8747-8750 Protein denotes p65
T5665 8755-8760 Protein denotes IκB-α
T5666 8791-8800 Protein denotes siRNA p65
T5667 8805-8810 Protein denotes IκB-α
T6037 8964-8967 Protein denotes Tat
T6038 9001-9004 Protein denotes Env
T6039 9232-9235 Protein denotes Env
T6040 9267-9270 Protein denotes p24
T6277 10612-10619 Binding denotes Binding true
T6278 10623-10626 Protein denotes p65 true
T6279 10628-10631 Protein denotes p50 true
T6280 10636-10644 Protein denotes FLAG-Tat
T6702 10954-10962 Protein denotes HA-IκB-α
T6703 10964-10967 Protein denotes p65
T6704 10972-10975 Protein denotes Tat
T6705 10981-10990 Gene_expression denotes expressed
T6873 11214-11217 Protein denotes GST
T6874 11249-11252 Protein denotes GST
T7496 13252-13261 Protein denotes protein G
T7497 13594-13603 Protein denotes protein G
T7498 14484-14490 Protein denotes MIP-1α
T7499 14492-14497 Protein denotes GAPDH
T7500 14502-14506 Protein denotes ACTB
T7501 14558-14562 Protein denotes CSF3
T7502 14564-14567 Protein denotes LTA
T7503 14569-14575 Protein denotes NFKBIA
T7504 14580-14584 Protein denotes TLR2
T8360 14991-14994 Protein denotes Tat
T8361 15026-15035 Binding denotes hijacking
T8362 15036-15041 Protein denotes IκB-α
T8363 15174-15184 Regulation denotes modulating
T8364 15189-15199 Gene_expression denotes expression
T8365 15203-15206 Protein denotes Tat
T8366 15265-15274 Protein denotes siRNA Tat
T8367 15359-15362 Protein denotes Env
T8368 15538-15548 Gene_expression denotes expression
T8369 15552-15555 Protein denotes Tat
T8370 15609-15618 Positive_regulation denotes increased true
T8371 15716-15725 Protein denotes siRNA Tat true
T8372 15765-15774 Regulation denotes dependent
T8373 15775-15785 Protein denotes luciferase
T8374 15786-15796 Gene_expression denotes expression
T8375 15820-15827 Positive_regulation denotes induced
T8376 15943-15952 Protein denotes siRNA Tat
T8377 15992-15995 Protein denotes Tat
T8378 17304-17307 Protein denotes p65
T8379 17308-17311 Protein denotes p50
T8380 17312-17319 Binding denotes binding
T8381 17382-17385 Protein denotes p65
T8382 17457-17460 Protein denotes Tat
T8383 17502-17505 Protein denotes Tat
T8384 17506-17514 Negative_regulation denotes negative
T8385 17516-17525 Protein denotes siRNA Tat
T8386 17571-17574 Protein denotes p65
T8387 17579-17586 Binding denotes binding
T8388 17591-17598 Entity denotes nuclear
T8389 17599-17602 Protein denotes p65 true
T8390 17613-17621 Positive_regulation denotes elevated
T8391 17637-17640 Protein denotes Tat true
T8392 17693-17700 Negative_regulation denotes absence
T8393 17704-17707 Protein denotes Tat
T8394 17709-17718 Protein denotes siRNA Tat
T8395 17739-17744 Protein denotes IκB-α
T8396 17749-17757 Protein_catabolism denotes degraded
T8397 17885-17888 Protein denotes Tat
T8398 17902-17905 Protein denotes Tat
T8399 18078-18081 Protein denotes Tat
T8400 18150-18155 Protein denotes IκB-α
T8401 18156-18167 Protein_catabolism denotes degradation
T8402 18168-18180 Gene_expression denotes re-synthesis
T8403 18492-18497 Protein denotes IκB-α
T8404 18498-18509 Protein_catabolism denotes degradation true
T8405 18543-18546 Protein denotes Tat
T8406 18564-18572 Positive_regulation denotes elevated true
T8407 18588-18591 Protein denotes Tat
T8408 18592-18601 Positive_regulation denotes following true
T8409 18640-18649 Gene_expression denotes synthesis
T8410 18653-18658 Protein denotes IκB-α
T11416 22496-22499 Protein denotes Tat
T11417 22500-22511 Negative_regulation denotes counteracts
T11418 22516-22521 Protein denotes IκB-α
T11419 22522-22532 Negative_regulation denotes inhibition
T11420 22536-22539 Protein denotes p65
T11421 22567-22574 Binding denotes binding true
T11422 22612-22623 Binding denotes interaction true
T11423 22627-22630 Protein denotes Tat
T11424 22636-22641 Protein denotes IκB-α
T11425 22759-22768 Positive_regulation denotes following
T11426 22769-22772 Protein denotes Tat
T11427 22782-22797 Protein denotes Tat T,N(23,24)A
T11428 22799-22815 Protein denotes Tat C(22,25,27)A
T11429 22817-22830 Protein denotes Tat K(50,51)A
T11430 22835-22848 Protein denotes Tat R(49–57)A true
T11431 22862-22867 Protein denotes IκB-α true
T11432 22868-22888 Binding denotes coimmunoprecipitated
T11433 22898-22901 Protein denotes Tat true
T11434 22919-22932 Protein denotes Tat R(49–57)A
T11435 22979-22999 Entity denotes arginine-rich domain
T11436 23003-23006 Protein denotes Tat
T11437 23027-23034 Binding denotes binding
T11438 23038-23043 Protein denotes IκB-α true
T11439 23112-23115 Protein denotes Tat true
T11440 23116-23127 Binding denotes associating
T11441 23133-23138 Protein denotes IκB-α
T11442 23139-23147 Negative_regulation denotes competed
T11443 23152-23159 Binding denotes binding true
T11444 23163-23168 Protein denotes IκB-α true
T11445 23172-23175 Protein denotes p65
T11446 23233-23246 Protein denotes Tat R(49–57)A
T11447 23254-23260 Negative_regulation denotes lacked
T11448 23265-23272 Binding denotes binding
T11449 23282-23287 Protein denotes IκB-α
T11450 23297-23306 Binding denotes associate
T11451 23312-23317 Protein denotes IκB-α
T11452 23330-23337 Negative_regulation denotes compete
T11453 23342-23349 Binding denotes binding
T11454 23353-23358 Protein denotes IκB-α
T11455 23362-23365 Protein denotes p65
T11456 25511-25514 Protein denotes Tat
T11457 25515-25527 Negative_regulation denotes counteracted
T11458 25532-25537 Protein denotes IκB-α
T11459 25538-25546 Positive_regulation denotes mediated
T11460 25547-25557 Negative_regulation denotes inhibition
T11461 25561-25564 Protein denotes p65
T11462 25565-25572 Binding denotes binding
T11463 25614-25617 Protein denotes p65
T11464 25622-25627 Protein denotes IκB-α
T11465 25673-25680 Negative_regulation denotes absence
T11466 25684-25687 Protein denotes Tat
T11467 25710-25713 Protein denotes p65
T11468 25718-25725 Binding denotes binding
T11469 25739-25748 Negative_regulation denotes inhibited
T11470 25752-25757 Protein denotes IκB-α
T11471 25781-25790 Regulation denotes dependent
T11472 25811-25814 Protein denotes Tat
T11473 25827-25839 Protein denotes Tat R(49–57)
T11474 25878-25881 Protein denotes Tat
T11475 25882-25888 Regulation denotes effect
T11476 25896-25901 Protein denotes IκB-α
T11477 25902-25912 Negative_regulation denotes repression
T11478 25916-25919 Protein denotes p65
T11479 25920-25935 Transcription denotes transcriptional
T11480 25961-25964 Protein denotes p50
T11481 25964-25965 Gene_expression denotes −
T11482 25967-25970 Protein denotes p65
T11483 25970-25972 Gene_expression denotes −/
T11484 25993-25996 Protein denotes Luc
T11485 26020-26030 Gene_expression denotes expression
T11486 26042-26045 Protein denotes p65
T11487 26050-26055 Protein denotes IκB-α
T11488 26072-26079 Negative_regulation denotes absence
T11489 26083-26086 Protein denotes Tat
T11490 26088-26093 Protein denotes IκB-α
T11491 26094-26103 Negative_regulation denotes inhibited
T11492 26108-26111 Protein denotes p65
T11493 26112-26121 Positive_regulation denotes dependent
T11494 26122-26132 Gene_expression denotes expression
T11495 26140-26150 Protein denotes luciferase
T11496 26186-26195 Regulation denotes dependent
T11497 26216-26219 Protein denotes Tat
T11498 26232-26245 Protein denotes Tat R(49–57)A
T11499 26299-26302 Protein denotes Tat
T11500 26303-26314 Negative_regulation denotes counteracts
T11501 26319-26324 Protein denotes IκB-α
T11502 26325-26335 Negative_regulation denotes repression
T11503 26343-26346 Protein denotes p65
T11504 26351-26358 Binding denotes binding
T11505 26363-26378 Transcription denotes transcriptional
T11506 26391-26402 Binding denotes associating
T11507 26408-26413 Protein denotes IκB-α
T11508 26418-26427 Negative_regulation denotes competing
T11509 26442-26449 Binding denotes binding
T11510 26453-26456 Protein denotes p65
T13162 26459-26462 Protein denotes Tat
T13163 26463-26472 Positive_regulation denotes increases
T13164 26477-26480 Protein denotes p65
T13165 26490-26497 Binding denotes binding true
T13166 26513-26524 Binding denotes association
T13167 26530-26533 Protein denotes p65
T13168 26552-26555 Protein denotes Tat
T13169 26567-26577 Binding denotes interacted
T13170 26583-26586 Protein denotes p65
T13171 26625-26635 Gene_expression denotes expression true
T13172 26647-26653 Protein denotes HA-p65
T13173 26658-26666 Protein denotes FLAG-Tat true
T13174 26683-26686 Protein denotes Tat true
T13175 26734-26737 Protein denotes p65
T13176 26750-26770 Binding denotes coimmunoprecipitated
T13177 26786-26789 Protein denotes Tat
T13178 26805-26820 Protein denotes Tat T,N(23,24)A true
T13179 26822-26835 Protein denotes Tat K(50,51)A
T13180 26840-26853 Protein denotes Tat R(49–57)A true
T13181 26893-26901 Negative_regulation denotes decrease
T13182 26944-26960 Protein denotes Tat C(22,25,27)A true
T13183 26988-26991 Protein denotes GST
T13184 27052-27059 Binding denotes binding
T13185 27063-27066 Protein denotes p65
T13186 27080-27083 Protein denotes Tat
T13187 27100-27115 Protein denotes Tat T,N(23,24)A true
T13188 27117-27130 Protein denotes Tat K(50,51)A true
T13189 27135-27148 Protein denotes Tat R(49–57)A
T13190 27154-27158 Negative_regulation denotes lack
T13191 27162-27169 Binding denotes binding
T13192 27173-27189 Protein denotes Tat C(22,25,27)A
T13193 27232-27235 Protein denotes Tat
T13194 27236-27246 Binding denotes associated
T13195 27252-27255 Protein denotes p65
T13196 27268-27288 Entity denotes cysteine-rich domain
T13197 27356-27367 Binding denotes interaction
T13198 29109-29112 Protein denotes p65
T13199 29113-29119 Entity denotes domain
T13200 29120-29128 Positive_regulation denotes required
T13201 29133-29140 Binding denotes binding
T13202 29144-29147 Protein denotes Tat
T13203 29165-29176 Gene_expression denotes transfected
T13204 29182-29190 Protein denotes FLAG-Tat
T13205 29205-29211 Protein denotes HA-p65
T13206 29232-29239 Negative_regulation denotes deleted
T13207 29247-29269 Entity denotes transactivation domain
T13208 29271-29286 Protein denotes p65ΔC (1–318)],
T13209 29294-29297 Entity denotes RHD
T13210 29299-29315 Protein denotes p65ΔN (122–551)]
T13211 29329-29332 Protein denotes Tat
T13212 29333-29353 Binding denotes coimmunoprecipitated
T13213 29359-29373 Protein denotes p65ΔC (1–318),
T13214 29387-29402 Protein denotes p65ΔN (122–551)
T13215 29436-29439 Entity denotes RHD
T13216 29443-29446 Protein denotes p65
T13217 29476-29487 Binding denotes interaction
T13218 29493-29496 Protein denotes Tat
T13219 29513-29519 Regulation denotes effect
T13220 29523-29526 Protein denotes Tat
T13221 29534-29537 Protein denotes p65
T13222 29542-29549 Binding denotes binding
T13223 29581-29584 Protein denotes p65
T13224 29698-29701 Protein denotes Tat
T13225 29705-29721 Protein denotes Tat C(22,25,27)A
T13226 29727-29730 Protein denotes p65
T13227 29735-29742 Binding denotes binding
T13228 29783-29786 Protein denotes Tat
T13229 29801-29810 Positive_regulation denotes increased
T13230 29815-29822 Binding denotes binding
T13231 29826-29829 Protein denotes p65
T13232 29849-29865 Protein denotes Tat C(22,25,27)A
T13233 29867-29874 Negative_regulation denotes lacking
T13234 29879-29886 Binding denotes binding
T13235 29896-29899 Protein denotes p65
T13236 29934-29937 Protein denotes p65
T13237 29938-29945 Binding denotes binding
T13238 30066-30069 Protein denotes Tat
T13239 30084-30092 Positive_regulation denotes enhanced
T13240 30097-30100 Protein denotes p65
T13241 30110-30117 Binding denotes binding
T14963 30145-30148 Protein denotes Tat
T14964 30163-30166 Protein denotes p65
T14965 30215-30223 Binding denotes occupies
T14966 30248-30256 Positive_regulation denotes promotes
T14967 30261-30264 Protein denotes p65 true
T14968 30265-30276 Binding denotes recruitment
T14969 30282-30287 Protein denotes IκB-α
T14970 30288-30300 Binding denotes displacement
T14971 30327-30330 Protein denotes Tat
T14972 30430-30438 Protein denotes FLAG-Tat
T14973 30440-30461 Protein denotes FLAG-Tat C(22,25,27)A
T14974 30465-30483 Protein denotes FLAG-Tat R(49–57)A
T14975 30504-30514 Gene_expression denotes expression
T14976 30583-30586 Protein denotes Tat
T14977 30601-30610 Positive_regulation denotes increased
T14978 30615-30625 Gene_expression denotes expression true
T14979 30629-30635 Protein denotes MIP-1α true
T14980 30637-30641 Protein denotes CSF3 true
T14981 30643-30646 Protein denotes LTA true
T14982 30648-30654 Protein denotes NFKBIA true
T14983 30659-30663 Protein denotes TLR2 true
T14984 30683-30699 Protein denotes Tat C(22,25,27)A true
T14985 30704-30717 Protein denotes Tat R(49–57)A true
T14986 30754-30757 Protein denotes Tat true
T14987 30860-30869 Protein denotes siRNA p65 true
T14988 30891-30894 Protein denotes Tat
T14989 30926-30934 Positive_regulation denotes mediated
T14990 30938-30941 Protein denotes p65
T14991 31016-31021 Protein denotes GAPDH
T14992 31026-31030 Protein denotes ACTB
T14993 31063-31066 Protein denotes Tat
T14994 31200-31203 Protein denotes Tat
T14995 31298-31301 Protein denotes Tat
T14996 31331-31342 Binding denotes interaction true
T14997 31369-31372 Protein denotes p65 true
T14998 31377-31382 Protein denotes IκB-α
T14999 32978-32984 Protein denotes MIP-1α
T15000 33025-33028 Protein denotes Tat
T15001 33148-33154 Protein denotes MIP-1α
T15002 33155-33165 Gene_expression denotes expression true
T15003 33170-33179 Positive_regulation denotes increased
T15004 33247-33253 Protein denotes MIP-1α
T15005 33254-33264 Gene_expression denotes production
T15006 33269-33276 Positive_regulation denotes induced
T15007 33308-33311 Protein denotes Tat
T15008 33352-33362 Regulation denotes regulation
T15009 33366-33372 Protein denotes MIP-1α
T15010 33535-33541 Protein denotes MIP-1α
T15011 33723-33729 Protein denotes MIP-1α
T15012 33770-33775 Protein denotes TNF-α
T15013 33822-33832 Gene_expression denotes expression
T15014 33843-33849 Protein denotes MIP-1α true
T15015 33876-33879 Protein denotes p65 true
T15016 33880-33889 Binding denotes occupancy true
T15017 33897-33908 Entity denotes NF-κB sites
T15018 33918-33923 Protein denotes TNF-α
T15019 33924-33933 Positive_regulation denotes activated
T15020 33938-33948 Gene_expression denotes expression true
T15021 33952-33958 Protein denotes MIP-1α true
T15022 33963-33970 Positive_regulation denotes induced
T15023 33975-33978 Protein denotes p65
T15024 33979-33990 Binding denotes recruitment
T15025 33998-34009 Entity denotes NF-κB1 site
T15026 34013-34019 Protein denotes MIP-1α
T15027 34128-34131 Protein denotes Tat
T15028 34137-34145 Positive_regulation denotes promoted
T15029 34150-34161 Binding denotes recruitment
T15030 34165-34168 Protein denotes p65
T15031 34176-34187 Entity denotes NF-κB1 site
T15032 34191-34197 Protein denotes MIP-1α
T15033 34389-34395 Protein denotes MIP-1α
T15034 34408-34416 Positive_regulation denotes response
T15035 34420-34425 Protein denotes TNF-α
T15036 34430-34433 Protein denotes Tat
T15037 34448-34454 Protein denotes MIP-1α
T15038 34456-34459 Protein denotes Tat
T15039 34460-34469 Positive_regulation denotes increased
T15040 34474-34485 Binding denotes recruitment
T15041 34489-34492 Protein denotes p65
T15042 34500-34515 Entity denotes NF-κB enhancers
T15043 34519-34523 Protein denotes CSF3
T15044 34525-34528 Protein denotes LTA
T15045 34530-34536 Protein denotes NFKBIA
T15046 34541-34545 Protein denotes TLR2
T15047 34560-34571 Positive_regulation denotes ineffective
T15048 34579-34588 Entity denotes promoters
T15049 34592-34597 Protein denotes GAPDH
T15050 34602-34606 Protein denotes ACTB
T15051 34629-34632 Protein denotes Tat
T15052 34633-34638 Binding denotes bound
T15053 34689-34694 Protein denotes GAPDH
T15054 34699-34703 Protein denotes ACTB
T15055 34704-34713 Entity denotes promoters
T15056 34720-34724 Negative_regulation denotes loss
T15057 34728-34735 Binding denotes binding
T15058 34736-34745 Positive_regulation denotes following
T15059 34746-34749 Protein denotes p65
T15060 34754-34766 Negative_regulation denotes interference
T15061 34796-34799 Protein denotes Tat
T15062 34800-34809 Binding denotes occupancy
T15063 34823-34826 Protein denotes p65
T15064 34827-34838 Binding denotes interaction
T15065 34864-34869 Protein denotes IκB-α
T15066 34874-34884 Positive_regulation denotes chromatin-
T15067 34884-34902 Binding denotes immunoprecipitated
T15068 34929-34936 Negative_regulation denotes absence
T15069 34940-34943 Protein denotes Tat
T15070 34993-34996 Protein denotes Tat
T15071 35001-35010 Positive_regulation denotes following
T15072 35011-35016 Protein denotes IκB-α
T15073 35021-35033 Negative_regulation denotes interference
T15074 35063-35066 Protein denotes Tat
T15075 35067-35076 Negative_regulation denotes displaced
T15076 35077-35082 Protein denotes IκB-α
T17625 35128-35131 Protein denotes Tat
T17626 35164-35172 Positive_regulation denotes promotes
T17627 35193-35203 Positive_regulation denotes activation
T17628 35207-35213 Protein denotes MIP-1α
T17629 35217-35228 Binding denotes interacting
T17630 35234-35239 Protein denotes IκB-α true
T17631 35244-35247 Protein denotes p65
T17632 35273-35276 Protein denotes Tat
T17633 35313-35323 Gene_expression denotes expression
T17634 35327-35333 Protein denotes MIP-1α
T17635 35382-35385 Protein denotes Tat
T17636 35398-35406 Gene_expression denotes produced
T17637 35412-35415 Protein denotes Env
T17638 35434-35442 Protein denotes FLAG-Tat
T17639 35565-35574 Protein denotes siRNA Tat
T17640 35615-35623 Regulation denotes modulate
T17641 35628-35631 Protein denotes Tat
T17642 35632-35642 Gene_expression denotes expression
T17643 35729-35739 Gene_expression denotes expression
T17644 35743-35746 Protein denotes Tat true
T17645 35751-35754 Protein denotes p24
T17646 35830-35839 Protein denotes siRNA Tat
T17647 38161-38164 Protein denotes p65
T17648 38169-38176 Binding denotes binding
T17649 38182-38189 Positive_regulation denotes induced
T17650 38220-38223 Protein denotes Tat
T17651 38266-38269 Protein denotes Tat
T17652 38270-38278 Gene_expression denotes negative
T17653 38286-38295 Protein denotes siRNA Tat
T17654 38302-38311 Positive_regulation denotes increased
T17655 38328-38331 Protein denotes Tat
T17656 38332-38340 Gene_expression denotes positive
T17657 38360-38371 Protein_catabolism denotes Degradation
T17658 38375-38380 Protein denotes IκB-α
T17659 38425-38433 Positive_regulation denotes followed
T17660 38445-38454 Gene_expression denotes synthesis
T17661 38458-38463 Protein denotes IκB-α
T17662 38493-38496 Protein denotes Tat
T17663 38554-38561 Positive_regulation denotes induced
T17664 38628-38631 Protein denotes Tat
T17665 38928-38931 Protein denotes Tat
T17666 38936-38956 Binding denotes coimmunoprecipitated
T17667 38962-38967 Protein denotes IκB-α
T17668 38972-38975 Protein denotes p65
T17669 38993-39002 Positive_regulation denotes activated
T17670 39007-39013 Protein denotes MIP-1α
T17671 39014-39024 Gene_expression denotes expression
T17672 39030-39033 Protein denotes p65
T17673 39034-39043 Regulation denotes dependent
T17674 39068-39072 Negative_regulation denotes lack
T17675 39083-39092 Positive_regulation denotes following
T17676 39097-39109 Negative_regulation denotes interference
T17677 39113-39116 Protein denotes Tat
T17678 39120-39123 Protein denotes p65
T17679 39147-39150 Protein denotes Tat
T17680 39155-39158 Protein denotes p65
T17681 39169-39178 Binding denotes recruited
T17682 39186-39200 Entity denotes NF-κB enhancer
T17683 39204-39210 Protein denotes MIP-1α
T17684 39222-39225 Protein denotes p65
T17685 39226-39235 Binding denotes occupancy
T17686 39240-39249 Negative_regulation denotes abolished
T17687 39253-39262 Protein denotes siRNA Tat
T17688 39354-39357 Protein denotes Tat
T17689 39358-39368 Binding denotes associated
T17690 39374-39379 Protein denotes IκB-α
T17691 39384-39387 Protein denotes p65
T17692 39393-39400 Positive_regulation denotes induced
T17693 39405-39408 Protein denotes p65
T17694 39409-39418 Regulation denotes dependent
T17695 39419-39429 Positive_regulation denotes activation
T17696 39433-39439 Protein denotes MIP-1α
T17697 39440-39450 Gene_expression denotes expression
T17698 39459-39468 Binding denotes occupancy
T17699 39476-39482 Protein denotes MIP-1α
T17700 39496-39505 Positive_regulation denotes increased
T17701 39506-39517 Binding denotes recruitment
T17702 39521-39524 Protein denotes p65
T19459 39608-39611 Protein denotes Tat
T19460 39655-39658 Protein denotes Tat true
T19461 39659-39667 Positive_regulation denotes enhanced true
T19462 39672-39687 Transcription denotes transcriptional
T19463 39704-39707 Protein denotes p65
T19464 39752-39762 Binding denotes interacted
T19465 39772-39777 Protein denotes IκB-α
T19466 39834-39837 Protein denotes Tat
T19467 39870-39881 Binding denotes interaction true
T19468 39887-39892 Protein denotes IκB-α
T19469 39897-39900 Protein denotes p65
T19470 40006-40013 Negative_regulation denotes silence
T19471 40018-40021 Protein denotes Tat
T19472 40022-40032 Gene_expression denotes expression
T19473 40283-40288 Protein denotes IκB-α
T19474 40289-40300 Protein_catabolism denotes degradation
T19475 40308-40315 Negative_regulation denotes absence
T19476 40319-40322 Protein denotes Tat
T19477 40372-40381 Gene_expression denotes synthesis
T19478 40385-40390 Protein denotes IκB-α
T19479 40420-40428 Positive_regulation denotes elevated
T19480 40448-40451 Protein denotes Tat
T19481 40466-40480 Negative_regulation denotes down regulated
T19482 40486-40495 Negative_regulation denotes silencing
T19483 40503-40506 Protein denotes Tat true
T19484 40575-40578 Protein denotes Tat
T19485 40663-40668 Protein denotes IκB-α
T19486 40742-40745 Protein denotes Tat
T19487 40776-40779 Protein denotes Tat
T19488 40849-40860 Gene_expression denotes synthesized
T19489 40861-40866 Protein denotes IκB-α
T19490 40872-40875 Protein denotes Tat
T19491 40926-40937 Binding denotes association
T19492 40964-40969 Protein denotes IκB-α
T19493 40977-40987 Negative_regulation denotes interfered
T19494 40997-41007 Binding denotes generation
T19495 41015-41020 Protein denotes IκB-α
T19496 41021-41024 Protein denotes p65
T19497 41066-41069 Protein denotes Tat
T19498 41070-41078 Negative_regulation denotes competed
T19499 41087-41094 Binding denotes binding
T19500 41098-41103 Protein denotes IκB-α
T19501 41107-41110 Protein denotes p65
T19502 41115-41124 Negative_regulation denotes prevented
T19503 41129-41134 Protein denotes IκB-α
T19504 41135-41145 Negative_regulation denotes repression
T19505 41149-41152 Protein denotes p65
T19506 41199-41202 Protein denotes Tat
T19507 41203-41213 Binding denotes associated
T19508 41219-41222 Protein denotes p65
T19509 41227-41236 Positive_regulation denotes increased
T19510 41241-41244 Protein denotes p65 true
T19511 41245-41252 Binding denotes binding
T19512 41269-41283 Entity denotes NF-κB enhancer
T19513 41358-41366 Positive_regulation denotes stronger true
T19514 41367-41374 Binding denotes binding
T19515 41378-41381 Protein denotes p65
T19516 41417-41428 Binding denotes association true
T19517 41434-41437 Protein denotes Tat
T19518 41452-41458 Positive_regulation denotes caused
T19519 41476-41482 Regulation denotes change
T19520 41486-41489 Protein denotes p65
T19521 41521-41524 Protein denotes Tat
T19522 41525-41547 Entity denotes cysteine-rich sequence true
T19523 41580-41587 Binding denotes binding
T19524 41595-41598 Entity denotes RHD
T19525 41602-41605 Protein denotes p65
T19526 41645-41648 Protein denotes Tat
T19527 41649-41671 Entity denotes arginine-rich sequence true
T19528 41697-41705 Positive_regulation denotes required
T19529 41714-41721 Binding denotes binding
T19530 41729-41742 Entity denotes sixth ankyrin
T19531 41746-41751 Protein denotes IκB-α
T19532 41769-41778 Negative_regulation denotes releasing
T19533 41779-41782 Protein denotes p65
T19534 41792-41797 Protein denotes IκB-α
T19535 41798-41808 Negative_regulation denotes inhibition
T19536 41853-41856 Protein denotes Tat
T19537 41912-41921 Binding denotes hijacking
T19538 41926-41931 Protein denotes IκB-α
T19539 41943-41952 Negative_regulation denotes shielding
T19540 41953-41956 Protein denotes p65
T19541 41966-41971 Protein denotes IκB-α
T19542 41972-41979 Binding denotes embrace
T19543 41985-41994 Regulation denotes enforcing
T19544 41999-42002 Protein denotes p65
T19545 42003-42010 Binding denotes binding true
T19546 42039-42042 Protein denotes Tat
T19547 42085-42088 Protein denotes Tat true
T19548 42102-42113 Protein denotes Tat mutants
T19549 42114-42121 Negative_regulation denotes lacking
T19550 42247-42253 Protein denotes MIP-1α
T19551 42255-42259 Protein denotes CSF3
T19552 42261-42264 Protein denotes LTA
T19553 42266-42272 Protein denotes NFKBIA
T19554 42277-42281 Protein denotes TLR2
T19555 42318-42321 Protein denotes Tat true
T19556 42322-42331 Positive_regulation denotes increased
T19557 42336-42347 Binding denotes recruitment
T19558 42351-42354 Protein denotes p65
T19559 42362-42377 Entity denotes NF-κB enhancers
T19560 42443-42455 Negative_regulation denotes interference
T19561 42459-42462 Protein denotes p65
T19562 42463-42472 Negative_regulation denotes abolished
T19563 42477-42480 Protein denotes Tat
T19564 42481-42490 Binding denotes occupancy
T19565 42498-42501 Entity denotes NF-
T19566 42534-42537 Protein denotes Tat
T19567 42538-42545 Binding denotes binding
T19568 42553-42564 Entity denotes NF-κB sites
T19569 42569-42577 Positive_regulation denotes mediated
T19570 42581-42584 Protein denotes p65
T19571 42639-42642 Protein denotes Tat
T19572 42643-42652 Negative_regulation denotes displaced
T19573 42653-42656 Protein denotes p65
T19574 42666-42673 Binding denotes binding
T19575 42677-42682 Protein denotes IκB-α
T19576 42708-42717 Positive_regulation denotes increased
T19577 42722-42725 Protein denotes p65
T19578 42730-42737 Binding denotes binding
T19579 42755-42766 Binding denotes association
T19580 42792-42795 Protein denotes Tat
T19581 42803-42812 Positive_regulation denotes increased
T19582 42817-42828 Binding denotes recruitment
T19583 42832-42835 Protein denotes p65
T19584 42859-42868 Entity denotes promoters
T19585 42872-42883 Binding denotes associating
T19586 42889-42892 Protein denotes p65
T19587 42900-42911 Negative_regulation denotes interfering
T19588 42921-42929 Binding denotes assembly
T19589 42933-42936 Protein denotes p65
T19590 42956-42961 Protein denotes IκB-α
T19591 42976-42981 Protein denotes IκB-α
T19592 42992-43002 Binding denotes associated
T19593 43029-43036 Negative_regulation denotes absence
T19594 43040-43043 Protein denotes Tat
T19595 43083-43086 Protein denotes Tat
T19596 43140-43145 Protein denotes IκB-α
T19597 43173-43182 Binding denotes occupancy
T19598 43214-43219 Protein denotes IκB-α
T19599 43230-43240 Binding denotes associated
T19600 43274-43278 Protein denotes hes1
T19601 43279-43287 Entity denotes promoter
T19602 43315-43324 Positive_regulation denotes following
T19603 43325-43330 Protein denotes TNF-α
T19604 43375-43379 Protein denotes hes1
T19605 43380-43395 Transcription denotes transcriptional
T19606 43396-43406 Positive_regulation denotes activation
T19607 43523-43526 Protein denotes Tat
T19608 43565-43573 Negative_regulation denotes removing
T19609 43574-43579 Protein denotes IκB-α
T19610 43584-43593 Positive_regulation denotes promoting
T19611 43598-43601 Protein denotes p65
T19612 43602-43609 Binding denotes loading
T19613 44076-44079 Protein denotes Tat
T19614 44182-44185 Protein denotes Tat
T19615 44287-44290 Protein denotes Tat
T19616 44312-44323 Gene_expression denotes synthesized
T19617 44324-44329 Protein denotes IκB-α
T19618 44336-44357 Binding denotes coimmunoprecipitation
T19619 44361-44364 Protein denotes Tat
T19620 44370-44375 Protein denotes IκB-α
T19621 44380-44383 Protein denotes p65
T19622 44391-44400 Positive_regulation denotes induction
T19623 44404-44410 Protein denotes MIP-1α
T19624 44411-44421 Gene_expression denotes expression
T19625 44422-44431 Positive_regulation denotes dependent
T19626 44435-44438 Protein denotes Tat
T19627 44443-44446 Protein denotes p65
T19628 44453-44456 Protein denotes Tat
T19629 44457-44466 Binding denotes occupancy
T19630 44474-44480 Protein denotes MIP-1α
T19631 44481-44495 Entity denotes NF-κB enhancer
T19632 44512-44521 Positive_regulation denotes increased
T19633 44522-44533 Binding denotes recruitment
T19634 44537-44540 Protein denotes p65
T19635 44593-44596 Protein denotes Tat
T19636 44614-44625 Binding denotes interaction
T19637 44631-44634 Protein denotes p65
T19638 44639-44644 Protein denotes IκB-α
T19639 44781-44785 Protein denotes IL-6
T19640 44795-44800 Protein denotes TNF-α
T19641 44811-44817 Protein denotes MIP-1α
T19642 44848-44853 Protein denotes TNF-α
T19643 44858-44862 Protein denotes IL-6
T19644 44864-44867 Protein denotes Tat
T19645 44868-44877 Positive_regulation denotes activated
T19646 44905-44912 Binding denotes binding
T19647 45055-45058 Protein denotes Tat
T19648 45134-45142 Positive_regulation denotes required
T19649 45147-45155 Binding denotes assembly
T19650 45159-45162 Protein denotes Tat
T19651 45168-45171 Protein denotes p65
T19652 45179-45193 Entity denotes NF-κB enhancer
T19653 45212-45224 Binding denotes displacement
T19654 45228-45233 Protein denotes IκB-α
T19655 45299-45302 Protein denotes Tat
T19656 45412-45415 Protein denotes Tat
T19657 45416-45425 Positive_regulation denotes promoting
T19658 46088-46091 Protein denotes Tat
T19659 46123-46134 Binding denotes interaction
T19660 46140-46145 Protein denotes IκB-α
T19661 46150-46153 Protein denotes p65
T19662 46204-46207 Protein denotes Tat
T23883 16062-16065 Protein denotes Tat true
T23884 16194-16203 Protein denotes siRNA Tat true
T23885 16342-16345 Protein denotes p24 true
T23886 16388-16391 Protein denotes Tat true
T23887 16392-16402 Gene_expression denotes expression true
T23888 16457-16467 Protein denotes luciferase
T23889 16565-16568 Protein denotes p65
T23890 16573-16576 Protein denotes p50
T23891 16577-16584 Binding denotes binding
T23892 16701-16711 Gene_expression denotes expression
T23893 16715-16718 Protein denotes p65
T23894 16723-16728 Protein denotes IκB-α
T23895 16877-16890 Protein denotes Hexokinase II
T24329 20207-20210 Protein denotes Tat
T24330 20268-20279 Binding denotes associating true
T24331 20285-20290 Protein denotes IκB-α true
T24332 20382-20385 Protein denotes Tat true
T24333 20669-20672 Protein denotes p65
T24334 20674-20677 Protein denotes p50
T24335 20682-20690 Protein denotes FLAG-Tat
T24336 20691-20698 Binding denotes binding
T24337 21294-21297 Protein denotes Tat
T24338 21498-21507 Protein denotes protein G
T25130 23400-23403 Protein denotes Tat
T25131 23404-23412 Negative_regulation denotes relieves
T25132 23413-23416 Protein denotes p65 true
T25133 23426-23431 Protein denotes IκB-α true
T25134 23432-23442 Negative_regulation denotes inhibition
T25135 23497-23500 Protein denotes Tat
T25136 23515-23523 Protein denotes HA-IκB-α
T25137 23560-23567 Negative_regulation denotes absence
T25138 23571-23579 Protein denotes FLAG-Tat
T25139 23581-23601 Protein denotes FLAG-Tat T,N(23,24)A
T25140 23603-23621 Protein denotes FLAG-Tat K(50,51)A
T25141 23623-23641 Protein denotes FLAG-Tat R(49–57)A
T25142 23645-23666 Protein denotes FLAG-Tat C(22,25,27)A
T25143 23732-23735 Protein denotes Tat
T25144 23940-23943 Protein denotes p65
T25145 23990-23998 Protein denotes HA-IκB-α
T25146 24021-24028 Negative_regulation denotes absence
T25147 24032-24040 Protein denotes FLAG-Tat
T25148 24044-24062 Protein denotes FLAG-Tat R(49–57)A
T25149 24081-24089 Protein denotes HA-IκB-α
T25150 24283-24286 Protein denotes p65
T25151 24394-24397 Protein denotes p65
T25152 24402-24409 Binding denotes binding
T25153 24545-24548 Protein denotes p65
T25154 24573-24580 Negative_regulation denotes absence
T25155 24584-24592 Protein denotes HA-IκB-α
T25156 24601-24609 Protein denotes FLAG-Tat
T25157 24613-24631 Protein denotes FLAG-Tat R(49–57)A
T25158 24666-24673 Binding denotes binding
T25159 24861-24864 Protein denotes p50
T25160 24867-24870 Protein denotes p65
T25161 24940-24945 Protein denotes β-Gal
T25162 24979-24982 Protein denotes p65
T25163 24999-25007 Protein denotes HA-IκB-α
T25164 25026-25029 Protein denotes Tat
T25165 25041-25044 Protein denotes Tat
T25166 25078-25088 Protein denotes luciferase
T25167 25169-25184 Protein denotes β-galactosidase
T26440 27379-27382 Protein denotes Tat
T26441 27383-27393 Binding denotes associates
T26442 27399-27402 Protein denotes p65
T26443 27403-27413 Positive_regulation denotes increasing
T26444 27431-27438 Binding denotes binding
T26445 27485-27493 Protein denotes 3xHA-p65
T26446 27516-27523 Negative_regulation denotes absence
T26447 27535-27538 Protein denotes Tat
T26448 27548-27563 Protein denotes Tat T,N(23,24)A
T26449 27573-27586 Protein denotes Tat K(50,51)A
T26450 27596-27609 Protein denotes Tat R(49–57)A
T26451 27622-27638 Protein denotes Tat C(22,25,27)A
T26452 27647-27655 Protein denotes FLAG-Tat
T26453 27856-27859 Protein denotes p65
T26454 27886-27893 Protein denotes GST-Tat
T26455 27895-27914 Protein denotes GST-Tat T,N(23,24)A
T26456 27916-27933 Protein denotes GST-Tat K(50,51)A
T26457 27935-27952 Protein denotes GST-Tat R(49–57)A
T26458 27954-27974 Protein denotes GST-Tat C(22,25,27)A
T26459 27979-27982 Protein denotes GST
T26460 28065-28068 Protein denotes GST
T26461 28231-28234 Protein denotes p65
T26462 28290-28293 Protein denotes Tat
T26463 28339-28347 Protein denotes 3xHA-p65
T26464 28357-28367 Protein denotes 3xHA-p65ΔC
T26465 28388-28398 Protein denotes 3xHA-p65ΔN
T26466 28438-28444 Protein denotes HA-p65
T26467 28635-28638 Protein denotes p65
T26468 28810-28818 Protein denotes FLAG-Tat
T26469 28822-28843 Protein denotes FLAG-Tat C(22,25,27)A
T27195 31394-31397 Protein denotes Tat
T27196 31412-31415 Protein denotes p65
T27197 31466-31475 Binding denotes occupying
T27198 31500-31509 Positive_regulation denotes promoting
T27199 31514-31517 Protein denotes p65 true
T27200 31518-31529 Binding denotes recruitment
T27201 31535-31540 Protein denotes IκB-α true
T27202 31541-31553 Binding denotes displacement true
T27203 31606-31609 Protein denotes Tat true
T27204 31619-31635 Protein denotes Tat C(22,25,27), true
T27205 31644-31656 Protein denotes Tat R(49–57) true
T27206 31686-31689 Protein denotes p65 true
T27207 31694-31706 Negative_regulation denotes interference true
T27208 31754-31757 Protein denotes Tat
T27209 31770-31779 Protein denotes siRNA p65
T27210 31915-31925 Gene_expression denotes expression
T27211 31929-31935 Protein denotes MIP-1α
T27212 31941-31945 Protein denotes CSF3
T27213 31951-31954 Protein denotes LTA
T27214 31960-31966 Protein denotes NFKBIA
T27215 31972-31976 Protein denotes TLR2
T27216 31982-31987 Protein denotes GAPDH
T27217 31993-31997 Protein denotes ACTB
T27218 32064-32067 Protein denotes Tat
T27219 32302-32305 Protein denotes Tat
T27220 32340-32349 Protein denotes siRNA p65
T27221 32584-32587 Protein denotes Tat
T27222 32618-32629 Protein denotes siRNA IκB-α
T28234 35900-35903 Protein denotes Tat
T28235 35936-35944 Positive_regulation denotes enhances
T28236 35949-35955 Protein denotes MIP-1α
T28237 35956-35966 Gene_expression denotes expression true
T28238 35971-35982 Binding denotes interaction true
T28239 35988-35993 Protein denotes IκB-α true
T28240 35998-36001 Protein denotes p65
T28241 36046-36055 Protein denotes siRNA Tat
T28242 36163-36171 Protein denotes FLAG-Tat
T28243 36196-36199 Protein denotes p24
T28244 36282-36285 Protein denotes Tat
T28245 36286-36296 Gene_expression denotes expression
T28246 36327-36330 Protein denotes p24
T28247 36363-36370 Binding denotes binding
T28248 36374-36377 Protein denotes p65
T28249 36535-36540 Protein denotes IκB-α
T28250 36943-36951 Protein denotes FLAG-Tat
T28251 37069-37078 Protein denotes protein G
T28252 37296-37305 Protein denotes siRNA Tat
T28253 37307-37316 Protein denotes siRNA p65
T28254 37425-37433 Protein denotes FLAG-Tat
T28255 37528-37534 Protein denotes MIP-1α
T28256 37535-37545 Gene_expression denotes expression
T28257 37617-37626 Protein denotes siRNA Tat
T28258 37737-37745 Protein denotes FLAG-Tat
T28259 37922-37928 Protein denotes MIP-1α
T28260 37933-37938 Protein denotes GAPDH
T28261 37939-37948 Entity denotes promoters
T29064 43641-43647 Protein denotes MIP-1α
T29065 43664-43674 Positive_regulation denotes activation
T29066 43684-43687 Protein denotes Tat
T29067 43696-43703 Negative_regulation denotes absence
T29068 43707-43710 Protein denotes Tat true
T29069 43712-43717 Protein denotes IκB-α
T29070 43718-43726 Binding denotes occupies
T29071 43731-43745 Entity denotes NF-κB enhancer
T29072 43753-43759 Protein denotes MIP-1α
T29073 43780-43789 Binding denotes interacts
T29074 43878-43881 Protein denotes Tat
T29075 43882-43891 Positive_regulation denotes activates
T29076 43896-43902 Protein denotes MIP-1α
T29077 43903-43913 Gene_expression denotes expression
T29078 43917-43925 Negative_regulation denotes removing
T29079 43930-43935 Protein denotes IκB-α
T29080 43978-43988 Positive_regulation denotes increasing
T29081 43993-44000 Binding denotes binding
T29082 44029-44043 Entity denotes NF-κB enhancer
T46 31-34 Protein denotes Tat
T47 64-75 Binding denotes interaction
T48 81-86 Protein denotes IκB-α
T49 91-94 Protein denotes p65
T50 439-442 Protein denotes Tat
T51 477-486 Binding denotes hijacking
T52 491-500 Negative_regulation denotes inhibitor
T53 501-506 Protein denotes IκB-α
T54 539-546 Binding denotes binding
T55 579-582 Protein denotes Tat
T56 583-593 Binding denotes associated
T57 603-606 Protein denotes p65
T58 628-637 Positive_regulation denotes increased
T59 642-645 Protein denotes p65
T60 650-657 Binding denotes binding
T61 723-724 Entity denotes -
T62 740-743 Protein denotes Tat
T63 749-757 Positive_regulation denotes required
T64 762-767 Protein denotes IκB-α true
T65 772-775 Protein denotes p65
T66 776-787 Binding denotes association
T67 884-887 Protein denotes Tat
T68 895-904 Positive_regulation denotes activated
T69 909-915 Protein denotes MIP-1α
T70 916-926 Gene_expression denotes expression
T71 932-935 Protein denotes p65
T72 936-945 Regulation denotes dependent
T73 958-963 Binding denotes bound
T74 971-977 Protein denotes MIP-1α
T75 978-992 Entity denotes NF-κB enhancer
T76 998-1007 Positive_regulation denotes promoting
T77 1012-1023 Binding denotes recruitment
T6875 11282-11285 Protein denotes GST
T6988 11934-11937 Protein denotes Tat
T6989 11942-11948 Protein denotes MIP-1α
T6990 12000-12004 Protein denotes CSF3
T6991 12006-12009 Protein denotes LTA
T6992 12011-12017 Protein denotes NFKBIA
T6993 12019-12023 Protein denotes TLR2
T6994 12025-12030 Protein denotes GAPDH
T6995 12035-12039 Protein denotes ACTB
T6996 12242-12247 Protein denotes GAPDH
T6997 12356-12361 Protein denotes GAPDH
R36 T78 T79 themeOf p65,displacement
R37 T78 T77 themeOf p65,recruitment
R38 T79 T76 themeOf displacement,promoting
R39 T80 T79 themeOf IκB-α,displacement
R40 T86 T85 themeOf Tat,interaction
R41 T87 T85 themeOf IκB-α,interaction
R42 T88 T85 themeOf p65,interaction
R665 T62 T66 themeOf Tat,association
R666 T64 T66 themeOf IκB-α,association
R667 T64 T63 themeOf IκB-α,required
R669 T65 T63 themeOf p65,required
R670 T66 T63 themeOf association,required
R671 T67 T73 themeOf Tat,bound
R672 T67 T68 causeOf Tat,activated
R673 T69 T70 themeOf MIP-1α,expression
R674 T70 T68 themeOf expression,activated
R675 T72 T68 themeOf dependent,activated
R676 T73 T76 causeOf bound,promoting
R677 T75 T77 themeOf NF-κB enhancer,recruitment
R678 T75 T73 themeOf NF-κB enhancer,bound
R679 T75 T74 partOf NF-κB enhancer,MIP-1α
R680 T77 T76 themeOf recruitment,promoting
R974 T1138 T1145 themeOf RelA,binding
R975 T1139 T1145 themeOf p65,binding
R976 T1139 T1138 equivalentTo p65,RelA
R977 T1140 T1145 themeOf c-Rel,binding
R978 T1141 T1145 themeOf RelB,binding
R979 T1142 T1145 themeOf p50,binding
R980 T1143 T1145 themeOf p52,binding
R981 T1144 T1143 partOf Rel homology domain,p52
R982 T1144 T1142 partOf Rel homology domain,p50
R983 T1144 T1138 partOf Rel homology domain,RelA
R984 T1144 T1139 partOf Rel homology domain,p65
R985 T1144 T1140 partOf Rel homology domain,c-Rel
R986 T1144 T1141 partOf Rel homology domain,RelB
R987 T1150 T1157 themeOf IκB-α,degraded
R988 T1150 T1151 themeOf IκB-α,phosphorylated
R989 T1152 T1150 partOf Ser32,IκB-α
R990 T1152 T1151 themeOf Ser32,phosphorylated
R991 T1153 T1151 themeOf Ser36,phosphorylated
R992 T1153 T1150 partOf Ser36,IκB-α
R993 T1155 T1150 partOf Lys21,IκB-α
R994 T1155 T1154 themeOf Lys21,ubiquitylated
R995 T1156 T1154 themeOf Lys22,ubiquitylated
R996 T1156 T1150 partOf Lys22,IκB-α
R997 T1161 T1159 themeOf Ser276,phosphorylation
R998 T1161 T1160 partOf Ser276,p65
R999 T1164 T1160 partOf Ser536,p65
R1000 T1164 T1163 partOf Ser536,PKCζ
R1001 T1166 T1174 causeOf Acetylation,enhances
R1002 T1167 T1166 themeOf p65,Acetylation
R1003 T1167 T1170 themeOf p65,binding
R1004 T1168 T1167 partOf Lys218,p65
R1005 T1168 T1166 themeOf Lys218,Acetylation
R1006 T1172 T1171 themeOf association,impairs
R1007 T1173 T1172 themeOf IκB-α,association
R1008 T1175 T1176 themeOf p65,transcriptional
R1009 T1176 T1174 themeOf transcriptional,enhances
R1010 T1180 T1179 themeOf p65,Deacetylation
R1011 T1181 T1179 causeOf histone deacetylase-3,Deacetylation
R1012 T1182 T1179 causeOf SIRT1,Deacetylation
R1013 T1185 T1184 partOf Lys122,p65
R1014 T1185 T1183 themeOf Lys122,acetylation
R1015 T1186 T1183 themeOf Lys123,acetylation
R1016 T1186 T1184 partOf Lys123,p65
R1017 T1190 T1189 themeOf procaspase 8,activation
R1018 T1191 T1192 themeOf Tat,interacts
R1019 T1193 T1194 themeOf Tat,binds
R1020 T1196 T1195 equivalentTo TNFβ,tumor necrosis factor β
R1021 T1198 T1197 equivalentTo IL-6,interleukin-6
R1022 T1199 T1200 themeOf Tat,interacting
R1023 T1201 T1200 themeOf Sp1,interacting
R1024 T1202 T1200 themeOf TFIID,interacting
R1025 T1203 T1200 themeOf E2F-4,interacting
R1026 T1204 T1200 themeOf C/EBPβ,interacting
R1027 T1205 T1200 themeOf cyclin T1,interacting
R1028 T1206 T1200 themeOf CDK9,interacting
R1029 T1207 T1200 themeOf p300,interacting
R1030 T1208 T1200 themeOf CBP,interacting
R1031 T1209 T1200 themeOf P/CAF,interacting
R1032 T1210 T1211 themeOf Tat,binding
R1033 T1212 T1211 themeOf Flk1/KDR receptor,binding
R1034 T1214 T1213 themeOf Tat,expressed
R1035 T1215 T1219 causeOf Tat,increased
R1036 T1215 T1216 causeOf Tat,induced
R1037 T1215 T1222 causeOf Tat,inhibiting
R1038 T1217 T1216 themeOf degradation,induced
R1039 T1218 T1217 themeOf IκB-α,degradation
R1040 T1220 T1221 themeOf p65,transcriptional
R1041 T1221 T1219 themeOf transcriptional,increased
R1042 T1222 T1219 causeOf inhibiting,increased
R1043 T1223 T1224 causeOf SIRT-1,mediated
R1044 T1224 T1222 themeOf mediated,inhibiting
R1045 T1225 T1224 themeOf deacetylation,mediated
R1046 T1226 T1225 themeOf p65,deacetylation
R1047 T1227 T1229 causeOf Tat,dependent
R1048 T1228 T1229 causeOf Tat,dependent
R1049 T1230 T1229 themeOf synthesis,dependent
R1050 T1231 T1230 themeOf IκB-α,synthesis
R1051 T1232 T1237 themeOf IκB-α,export
R1052 T1232 T1233 themeOf IκB-α,binds
R1053 T1233 T1235 causeOf binds,promotes
R1054 T1234 T1233 themeOf Tat,binds
R1055 T1236 T1237 locationOf nuclear,export
R1056 T1237 T1235 themeOf export,promotes
R1057 T1238 T1242 themeOf Tat,binding
R1058 T1238 T1239 themeOf Tat,interaction
R1059 T1240 T1242 themeOf IκB-α,binding
R1060 T1240 T1239 themeOf IκB-α,interaction
R1061 T1241 T1239 themeOf p65,interaction
R6936 T8360 T8361 themeOf Tat,hijacking
R6937 T8362 T8361 themeOf IκB-α,hijacking
R6938 T8364 T8363 themeOf expression,modulating
R6939 T8365 T8364 themeOf Tat,expression
R6940 T8368 T8370 themeOf expression,increased
R6941 T8369 T8368 themeOf Tat,expression
R6942 T8372 T8375 themeOf dependent,induced
R6943 T8373 T8374 themeOf luciferase,expression
R6944 T8374 T8375 themeOf expression,induced
R6945 T8374 T8372 themeOf expression,dependent
R6946 T8376 T8375 causeOf siRNA Tat,induced
R6947 T8378 T8380 themeOf p65,binding
R6948 T8379 T8380 themeOf p50,binding
R6949 T8383 T8384 themeOf Tat,negative
R6950 T8386 T8387 themeOf p65,binding
R6951 T8387 T8390 themeOf binding,elevated
R6952 T8389 T8390 themeOf p65,elevated
R6953 T8391 T8390 causeOf Tat,elevated
R6954 T8392 T8390 causeOf absence,elevated
R6955 T8393 T8392 themeOf Tat,absence
R6956 T8395 T8396 themeOf IκB-α,degraded
R6957 T8400 T8401 themeOf IκB-α,degradation
R6958 T8400 T8402 themeOf IκB-α,re-synthesis
R6959 T8403 T8404 themeOf IκB-α,degradation
R6960 T8407 T8406 causeOf Tat,elevated
R6961 T8410 T8409 themeOf IκB-α,synthesis
R9324 T11416 T11417 causeOf Tat,counteracts
R9325 T11416 T11421 themeOf Tat,binding
R9326 T11418 T11419 causeOf IκB-α,inhibition
R9327 T11419 T11417 themeOf inhibition,counteracts
R9328 T11420 T11419 themeOf p65,inhibition
R9329 T11423 T11422 themeOf Tat,interaction
R9330 T11424 T11422 themeOf IκB-α,interaction
R9331 T11431 T11432 themeOf IκB-α,coimmunoprecipitated
R9332 T11433 T11432 themeOf Tat,coimmunoprecipitated
R9333 T11434 T11432 themeOf Tat R(49–57)A,coimmunoprecipitated
R9334 T11435 T11436 partOf arginine-rich domain,Tat
R9335 T11436 T11437 themeOf Tat,binding
R9336 T11438 T11437 themeOf IκB-α,binding
R9337 T11439 T11440 themeOf Tat,associating
R9338 T11440 T11442 causeOf associating,competed
R9339 T11441 T11440 themeOf IκB-α,associating
R9340 T11443 T11442 themeOf binding,competed
R9341 T11444 T11443 themeOf IκB-α,binding
R9342 T11445 T11443 themeOf p65,binding
R9343 T11446 T11450 themeOf Tat R(49–57)A,associate
R9344 T11448 T11447 themeOf binding,lacked
R9345 T11449 T11448 themeOf IκB-α,binding
R9346 T11451 T11450 themeOf IκB-α,associate
R9347 T11453 T11452 themeOf binding,compete
R9348 T11454 T11453 themeOf IκB-α,binding
R9349 T11455 T11453 themeOf p65,binding
R9350 T11456 T11457 causeOf Tat,counteracted
R9351 T11458 T11460 causeOf IκB-α,inhibition
R9352 T11458 T11459 causeOf IκB-α,mediated
R9353 T11459 T11457 themeOf mediated,counteracted
R9354 T11460 T11459 themeOf inhibition,mediated
R9355 T11461 T11462 themeOf p65,binding
R9356 T11462 T11460 themeOf binding,inhibition
R9357 T11466 T11465 themeOf Tat,absence
R9358 T11467 T11468 themeOf p65,binding
R9359 T11468 T11469 themeOf binding,inhibited
R9360 T11470 T11469 causeOf IκB-α,inhibited
R9361 T11472 T11469 causeOf Tat,inhibited
R9362 T11473 T11469 causeOf Tat R(49–57),inhibited
R9363 T11476 T11477 causeOf IκB-α,repression
R9364 T11477 T11475 themeOf repression,effect
R9365 T11478 T11479 themeOf p65,transcriptional
R9366 T11479 T11477 themeOf transcriptional,repression
R9367 T11486 T11485 themeOf p65,expression
R9368 T11487 T11485 themeOf IκB-α,expression
R9369 T11489 T11488 themeOf Tat,absence
R9370 T11490 T11491 causeOf IκB-α,inhibited
R9371 T11491 T11496 themeOf inhibited,dependent
R9372 T11492 T11493 causeOf p65,dependent
R9373 T11493 T11491 themeOf dependent,inhibited
R9374 T11493 T11496 themeOf dependent,dependent
R9375 T11494 T11493 themeOf expression,dependent
R9376 T11494 T11496 themeOf expression,dependent
R9377 T11495 T11494 themeOf luciferase,expression
R9378 T11499 T11506 themeOf Tat,associating
R9379 T11499 T11508 causeOf Tat,competing
R9380 T11501 T11502 causeOf IκB-α,repression
R9381 T11502 T11500 themeOf repression,counteracts
R9382 T11503 T11504 themeOf p65,binding
R9383 T11503 T11505 themeOf p65,transcriptional
R9384 T11504 T11502 themeOf binding,repression
R9385 T11505 T11502 themeOf transcriptional,repression
R9386 T11506 T11500 causeOf associating,counteracts
R9387 T11507 T11506 themeOf IκB-α,associating
R9388 T11508 T11502 causeOf competing,repression
R9389 T11508 T11500 causeOf competing,counteracts
R9390 T11509 T11508 themeOf binding,competing
R9391 T11510 T11509 themeOf p65,binding
R10655 T13162 T13163 causeOf Tat,increases
R10656 T13162 T13166 themeOf Tat,association
R10657 T13164 T13165 themeOf p65,binding
R10658 T13165 T13163 themeOf binding,increases
R10659 T13166 T13163 causeOf association,increases
R10660 T13167 T13166 themeOf p65,association
R10661 T13168 T13169 themeOf Tat,interacted
R10662 T13170 T13169 themeOf p65,interacted
R10663 T13172 T13171 themeOf HA-p65,expression
R10664 T13173 T13171 themeOf FLAG-Tat,expression
R10665 T13174 T13171 themeOf Tat,expression
R10666 T13175 T13176 themeOf p65,coimmunoprecipitated
R10667 T13177 T13176 themeOf Tat,coimmunoprecipitated
R10668 T13182 T13181 causeOf "Tat C(22,25,27)A",decrease
R10669 T13185 T13184 themeOf p65,binding
R10670 T13186 T13184 themeOf Tat,binding
R10671 T13187 T13184 themeOf "Tat T,N(23,24)A",binding
R10672 T13191 T13190 themeOf binding,lack
R10673 T13192 T13191 themeOf "Tat C(22,25,27)A",binding
R10674 T13193 T13197 themeOf Tat,interaction
R10675 T13193 T13194 themeOf Tat,associated
R10676 T13195 T13194 themeOf p65,associated
R10677 T13195 T13197 themeOf p65,interaction
R10678 T13196 T13193 partOf cysteine-rich domain,Tat
R10679 T13196 T13195 partOf cysteine-rich domain,p65
R10680 T13196 T13194 themeOf cysteine-rich domain,associated
R10681 T13198 T13201 themeOf p65,binding
R10682 T13198 T13203 themeOf p65,transfected
R10683 T13199 T13198 partOf domain,p65
R10684 T13199 T13200 causeOf domain,required
R10685 T13201 T13200 themeOf binding,required
R10686 T13202 T13203 themeOf Tat,transfected
R10687 T13202 T13201 themeOf Tat,binding
R10688 T13204 T13203 causeOf FLAG-Tat,transfected
R10689 T13207 T13206 themeOf transactivation domain,deleted
R10690 T13207 T13198 partOf transactivation domain,p65
R10691 T13209 T13198 partOf RHD,p65
R10692 T13209 T13206 themeOf RHD,deleted
R10693 T13211 T13212 themeOf Tat,coimmunoprecipitated
R10694 T13213 T13212 themeOf "p65ΔC (1–318),",coimmunoprecipitated
R10695 T13215 T13217 themeOf RHD,interaction
R10696 T13215 T13216 partOf RHD,p65
R10697 T13218 T13217 themeOf Tat,interaction
R10698 T13220 T13219 causeOf Tat,effect
R10699 T13221 T13222 themeOf p65,binding
R10700 T13222 T13219 themeOf binding,effect
R10701 T13226 T13227 themeOf p65,binding
R10702 T13228 T13229 causeOf Tat,increased
R10703 T13230 T13229 themeOf binding,increased
R10704 T13231 T13230 themeOf p65,binding
R10705 T13235 T13234 themeOf p65,binding
R10706 T13236 T13237 themeOf p65,binding
R10707 T13238 T13239 causeOf Tat,enhanced
R10708 T13240 T13241 themeOf p65,binding
R10709 T13241 T13239 themeOf binding,enhanced
R12000 T14963 T14965 themeOf Tat,occupies
R12001 T14963 T14966 causeOf Tat,promotes
R12002 T14967 T14970 themeOf p65,displacement
R12003 T14967 T14968 themeOf p65,recruitment
R12004 T14968 T14966 themeOf recruitment,promotes
R12005 T14969 T14970 themeOf IκB-α,displacement
R12006 T14970 T14966 themeOf displacement,promotes
R12007 T14976 T14977 causeOf Tat,increased
R12008 T14978 T14977 themeOf expression,increased
R12009 T14979 T14978 themeOf MIP-1α,expression
R12010 T14980 T14978 themeOf CSF3,expression
R12011 T14981 T14978 themeOf LTA,expression
R12012 T14982 T14978 themeOf NFKBIA,expression
R12013 T14983 T14978 themeOf TLR2,expression
R12014 T14990 T14989 causeOf p65,mediated
R12015 T14995 T14996 themeOf Tat,interaction
R12016 T14997 T14996 themeOf p65,interaction
R12017 T14998 T14996 themeOf IκB-α,interaction
R12018 T15001 T15002 themeOf MIP-1α,expression
R12019 T15002 T15003 themeOf expression,increased
R12020 T15004 T15005 themeOf MIP-1α,production
R12021 T15005 T15006 themeOf production,induced
R12022 T15007 T15006 causeOf Tat,induced
R12023 T15009 T15008 themeOf MIP-1α,regulation
R12024 T15014 T15013 themeOf MIP-1α,expression
R12025 T15015 T15016 themeOf p65,occupancy
R12026 T15017 T15015 partOf NF-κB sites,p65
R12027 T15017 T15014 partOf NF-κB sites,MIP-1α
R12028 T15017 T15013 themeOf NF-κB sites,expression
R12029 T15017 T15016 themeOf NF-κB sites,occupancy
R12030 T15018 T15019 causeOf TNF-α,activated
R12031 T15018 T15022 causeOf TNF-α,induced
R12032 T15020 T15019 themeOf expression,activated
R12033 T15021 T15020 themeOf MIP-1α,expression
R12034 T15023 T15024 themeOf p65,recruitment
R12035 T15024 T15022 themeOf recruitment,induced
R12036 T15025 T15024 themeOf NF-κB1 site,recruitment
R12037 T15025 T15026 partOf NF-κB1 site,MIP-1α
R12038 T15027 T15028 causeOf Tat,promoted
R12039 T15029 T15028 themeOf recruitment,promoted
R12040 T15030 T15029 themeOf p65,recruitment
R12041 T15031 T15032 partOf NF-κB1 site,MIP-1α
R12042 T15031 T15029 themeOf NF-κB1 site,recruitment
R12043 T15038 T15047 causeOf Tat,ineffective
R12044 T15038 T15039 causeOf Tat,increased
R12045 T15040 T15039 themeOf recruitment,increased
R12046 T15041 T15040 themeOf p65,recruitment
R12047 T15042 T15044 partOf NF-κB enhancers,LTA
R12048 T15042 T15046 partOf NF-κB enhancers,TLR2
R12049 T15042 T15040 themeOf NF-κB enhancers,recruitment
R12050 T15042 T15043 partOf NF-κB enhancers,CSF3
R12051 T15042 T15045 partOf NF-κB enhancers,NFKBIA
R12052 T15048 T15047 themeOf promoters,ineffective
R12053 T15048 T15050 partOf promoters,ACTB
R12054 T15048 T15049 partOf promoters,GAPDH
R12055 T15051 T15052 themeOf Tat,bound
R12056 T15052 T15056 themeOf bound,loss
R12057 T15055 T15053 partOf promoters,GAPDH
R12058 T15055 T15052 themeOf promoters,bound
R12059 T15059 T15060 themeOf p65,interference
R12060 T15060 T15056 causeOf interference,loss
R12061 T15061 T15062 themeOf Tat,occupancy
R12062 T15061 T15064 themeOf Tat,interaction
R12063 T15063 T15064 themeOf p65,interaction
R12064 T15069 T15068 themeOf Tat,absence
R12065 T15072 T15073 themeOf IκB-α,interference
R12066 T15074 T15075 causeOf Tat,displaced
R14134 T17625 T17629 themeOf Tat,interacting
R14135 T17625 T17626 causeOf Tat,promotes
R14136 T17627 T17626 themeOf activation,promotes
R14137 T17628 T17629 themeOf MIP-1α,interacting
R14138 T17628 T17627 themeOf MIP-1α,activation
R14139 T17630 T17629 themeOf IκB-α,interacting
R14140 T17634 T17633 themeOf MIP-1α,expression
R14141 T17641 T17642 themeOf Tat,expression
R14142 T17642 T17640 themeOf expression,modulate
R14143 T17644 T17643 themeOf Tat,expression
R14144 T17645 T17643 themeOf p24,expression
R14145 T17647 T17648 themeOf p65,binding
R14146 T17648 T17649 themeOf binding,induced
R14147 T17650 T17649 causeOf Tat,induced
R14148 T17651 T17649 causeOf Tat,induced
R14149 T17651 T17652 themeOf Tat,negative
R14150 T17652 T17649 causeOf negative,induced
R14151 T17653 T17649 causeOf siRNA Tat,induced
R14152 T17655 T17656 themeOf Tat,positive
R14153 T17656 T17649 causeOf positive,induced
R14154 T17658 T17657 themeOf IκB-α,Degradation
R14155 T17660 T17659 themeOf synthesis,followed
R14156 T17661 T17660 themeOf IκB-α,synthesis
R14157 T17664 T17663 causeOf Tat,induced
R14158 T17665 T17666 themeOf Tat,coimmunoprecipitated
R14159 T17665 T17669 causeOf Tat,activated
R14160 T17667 T17666 themeOf IκB-α,coimmunoprecipitated
R14161 T17668 T17666 themeOf p65,coimmunoprecipitated
R14162 T17669 T17673 causeOf activated,dependent
R14163 T17669 T17674 themeOf activated,lack
R14164 T17669 T17675 themeOf activated,following
R14165 T17670 T17671 themeOf MIP-1α,expression
R14166 T17671 T17669 themeOf expression,activated
R14167 T17671 T17673 themeOf expression,dependent
R14168 T17672 T17669 themeOf p65,activated
R14169 T17674 T17675 themeOf lack,following
R14170 T17676 T17675 causeOf interference,following
R14171 T17679 T17681 themeOf Tat,recruited
R14172 T17680 T17681 themeOf p65,recruited
R14173 T17682 T17681 themeOf NF-κB enhancer,recruited
R14174 T17682 T17685 themeOf NF-κB enhancer,occupancy
R14175 T17682 T17683 partOf NF-κB enhancer,MIP-1α
R14176 T17684 T17685 themeOf p65,occupancy
R14177 T17685 T17686 themeOf occupancy,abolished
R14178 T17687 T17686 causeOf siRNA Tat,abolished
R14179 T17688 T17698 themeOf Tat,occupancy
R14180 T17688 T17689 themeOf Tat,associated
R14181 T17690 T17689 themeOf IκB-α,associated
R14182 T17691 T17689 themeOf p65,associated
R14183 T17693 T17694 causeOf p65,dependent
R14184 T17693 T17695 causeOf p65,activation
R14185 T17694 T17692 themeOf dependent,induced
R14186 T17695 T17694 themeOf activation,dependent
R14187 T17696 T17697 themeOf MIP-1α,expression
R14188 T17697 T17695 themeOf expression,activation
R14189 T17698 T17695 causeOf occupancy,activation
R14190 T17698 T17692 causeOf occupancy,induced
R14191 T17701 T17700 themeOf recruitment,increased
R14192 T17702 T17701 themeOf p65,recruitment
R15547 T19460 T19464 themeOf Tat,interacted
R15548 T19460 T19461 causeOf Tat,enhanced
R15549 T19462 T19461 themeOf transcriptional,enhanced
R15550 T19463 T19462 themeOf p65,transcriptional
R15551 T19463 T19464 themeOf p65,interacted
R15552 T19465 T19464 themeOf IκB-α,interacted
R15553 T19466 T19467 themeOf Tat,interaction
R15554 T19468 T19467 themeOf IκB-α,interaction
R15555 T19469 T19467 themeOf p65,interaction
R15556 T19471 T19472 themeOf Tat,expression
R15557 T19472 T19470 themeOf expression,silence
R15558 T19473 T19474 themeOf IκB-α,degradation
R15559 T19476 T19475 themeOf Tat,absence
R15560 T19477 T19479 themeOf synthesis,elevated
R15561 T19478 T19477 themeOf IκB-α,synthesis
R15562 T19480 T19479 causeOf Tat,elevated
R15563 T19482 T19481 causeOf silencing,down regulated
R15564 T19483 T19482 themeOf Tat,silencing
R15565 T19489 T19488 themeOf IκB-α,synthesized
R15566 T19490 T19491 themeOf Tat,association
R15567 T19491 T19493 causeOf association,interfered
R15568 T19492 T19491 themeOf IκB-α,association
R15569 T19494 T19493 themeOf generation,interfered
R15570 T19495 T19494 themeOf IκB-α,generation
R15571 T19496 T19494 themeOf p65,generation
R15572 T19497 T19502 causeOf Tat,prevented
R15573 T19497 T19498 causeOf Tat,competed
R15574 T19499 T19498 themeOf binding,competed
R15575 T19500 T19499 themeOf IκB-α,binding
R15576 T19501 T19499 themeOf p65,binding
R15577 T19503 T19504 causeOf IκB-α,repression
R15578 T19504 T19502 themeOf repression,prevented
R15579 T19505 T19504 themeOf p65,repression
R15580 T19506 T19507 themeOf Tat,associated
R15581 T19506 T19509 causeOf Tat,increased
R15582 T19508 T19507 themeOf p65,associated
R15583 T19510 T19511 themeOf p65,binding
R15584 T19511 T19509 themeOf binding,increased
R15585 T19512 T19511 themeOf NF-κB enhancer,binding
R15586 T19514 T19513 themeOf binding,stronger
R15587 T19515 T19514 themeOf p65,binding
R15588 T19515 T19516 themeOf p65,association
R15589 T19516 T19518 causeOf association,caused
R15590 T19517 T19516 themeOf Tat,association
R15591 T19520 T19519 themeOf p65,change
R15592 T19521 T19523 themeOf Tat,binding
R15593 T19522 T19521 partOf cysteine-rich sequence,Tat
R15594 T19524 T19525 partOf RHD,p65
R15595 T19524 T19523 themeOf RHD,binding
R15596 T19526 T19532 causeOf Tat,releasing
R15597 T19526 T19529 themeOf Tat,binding
R15598 T19527 T19532 causeOf arginine-rich sequence,releasing
R15599 T19527 T19528 causeOf arginine-rich sequence,required
R15600 T19527 T19526 partOf arginine-rich sequence,Tat
R15601 T19529 T19528 themeOf binding,required
R15602 T19529 T19532 causeOf binding,releasing
R15603 T19530 T19531 partOf sixth ankyrin,IκB-α
R15604 T19530 T19529 themeOf sixth ankyrin,binding
R15605 T19533 T19535 themeOf p65,inhibition
R15606 T19534 T19535 themeOf IκB-α,inhibition
R15607 T19535 T19532 themeOf inhibition,releasing
R15608 T19536 T19543 causeOf Tat,enforcing
R15609 T19536 T19539 causeOf Tat,shielding
R15610 T19536 T19537 themeOf Tat,hijacking
R15611 T19538 T19537 themeOf IκB-α,hijacking
R15612 T19540 T19542 themeOf p65,embrace
R15613 T19541 T19542 themeOf IκB-α,embrace
R15614 T19542 T19539 themeOf embrace,shielding
R15615 T19544 T19545 themeOf p65,binding
R15616 T19545 T19543 themeOf binding,enforcing
R15617 T19555 T19556 causeOf Tat,increased
R15618 T19557 T19556 themeOf recruitment,increased
R15619 T19558 T19557 themeOf p65,recruitment
R15620 T19559 T19557 themeOf NF-κB enhancers,recruitment
R15621 T19559 T19558 partOf NF-κB enhancers,p65
R15622 T19563 T19564 themeOf Tat,occupancy
R15623 T19564 T19562 themeOf occupancy,abolished
R15624 T19566 T19567 themeOf Tat,binding
R15625 T19567 T19569 themeOf binding,mediated
R15626 T19568 T19567 themeOf NF-κB sites,binding
R15627 T19570 T19569 causeOf p65,mediated
R15628 T19571 T19579 themeOf Tat,association
R15629 T19571 T19576 causeOf Tat,increased
R15630 T19571 T19572 causeOf Tat,displaced
R15631 T19573 T19574 themeOf p65,binding
R15632 T19574 T19572 themeOf binding,displaced
R15633 T19575 T19574 themeOf IκB-α,binding
R15634 T19577 T19578 themeOf p65,binding
R15635 T19577 T19579 themeOf p65,association
R15636 T19578 T19576 themeOf binding,increased
R15637 T19579 T19576 causeOf association,increased
R15638 T19579 T19572 causeOf association,displaced
R15639 T19580 T19581 causeOf Tat,increased
R15640 T19580 T19585 themeOf Tat,associating
R15641 T19580 T19587 causeOf Tat,interfering
R15642 T19582 T19581 themeOf recruitment,increased
R15643 T19583 T19582 themeOf p65,recruitment
R15644 T19584 T19582 locationOf promoters,recruitment
R15645 T19585 T19581 causeOf associating,increased
R15646 T19586 T19585 themeOf p65,associating
R15647 T19587 T19581 causeOf interfering,increased
R15648 T19588 T19587 themeOf assembly,interfering
R15649 T19589 T19588 themeOf p65,assembly
R15650 T19590 T19588 themeOf IκB-α,assembly
R15651 T19591 T19592 themeOf IκB-α,associated
R15652 T19594 T19593 themeOf Tat,absence
R15653 T19596 T19597 themeOf IκB-α,occupancy
R15654 T19598 T19599 themeOf IκB-α,associated
R15655 T19601 T19599 themeOf promoter,associated
R15656 T19601 T19600 partOf promoter,hes1
R15657 T19603 T19602 causeOf TNF-α,following
R15658 T19604 T19606 themeOf hes1,activation
R15659 T19607 T19610 causeOf Tat,promoting
R15660 T19607 T19608 causeOf Tat,removing
R15661 T19609 T19608 themeOf IκB-α,removing
R15662 T19611 T19612 themeOf p65,loading
R15663 T19612 T19610 themeOf loading,promoting
R15664 T19617 T19616 themeOf IκB-α,synthesized
R15665 T19619 T19618 themeOf Tat,coimmunoprecipitation
R15666 T19620 T19618 themeOf IκB-α,coimmunoprecipitation
R15667 T19621 T19618 themeOf p65,coimmunoprecipitation
R15668 T19622 T19625 themeOf induction,dependent
R15669 T19623 T19624 themeOf MIP-1α,expression
R15670 T19624 T19622 themeOf expression,induction
R15671 T19626 T19622 causeOf Tat,induction
R15672 T19626 T19625 causeOf Tat,dependent
R15673 T19627 T19625 causeOf p65,dependent
R15674 T19628 T19625 causeOf Tat,dependent
R15675 T19628 T19629 themeOf Tat,occupancy
R15676 T19629 T19625 causeOf occupancy,dependent
R15677 T19631 T19629 themeOf NF-κB enhancer,occupancy
R15678 T19631 T19630 partOf NF-κB enhancer,MIP-1α
R15679 T19631 T19633 themeOf NF-κB enhancer,recruitment
R15680 T19633 T19632 themeOf recruitment,increased
R15681 T19634 T19633 themeOf p65,recruitment
R15682 T19635 T19636 themeOf Tat,interaction
R15683 T19637 T19636 themeOf p65,interaction
R15684 T19638 T19636 themeOf IκB-α,interaction
R15685 T19644 T19646 themeOf Tat,binding
R15686 T19649 T19648 themeOf assembly,required
R15687 T19650 T19649 themeOf Tat,assembly
R15688 T19651 T19649 themeOf p65,assembly
R15689 T19652 T19649 themeOf NF-κB enhancer,assembly
R15690 T19652 T19651 partOf NF-κB enhancer,p65
R15691 T19654 T19653 themeOf IκB-α,displacement
R15692 T19658 T19659 themeOf Tat,interaction
R15693 T19660 T19659 themeOf IκB-α,interaction
R15694 T19661 T19659 themeOf p65,interaction
R19057 T23886 T23887 themeOf Tat,expression
R19058 T23889 T23891 themeOf p65,binding
R19059 T23890 T23891 themeOf p50,binding
R19060 T23893 T23892 themeOf p65,expression
R19061 T23894 T23892 themeOf IκB-α,expression
R19344 T24329 T24330 themeOf Tat,associating
R19345 T24331 T24330 themeOf IκB-α,associating
R19346 T24333 T24336 themeOf p65,binding
R19347 T24334 T24336 themeOf p50,binding
R19348 T24335 T24336 themeOf FLAG-Tat,binding
R20015 T25130 T25131 causeOf Tat,relieves
R20016 T25132 T25134 themeOf p65,inhibition
R20017 T25133 T25134 causeOf IκB-α,inhibition
R20018 T25134 T25131 themeOf inhibition,relieves
R20019 T25147 T25146 themeOf FLAG-Tat,absence
R20020 T25151 T25152 themeOf p65,binding
R20021 T25155 T25158 themeOf HA-IκB-α,binding
R20022 T25155 T25154 themeOf HA-IκB-α,absence
R20023 T25156 T25158 themeOf FLAG-Tat,binding
R20024 T25157 T25158 themeOf FLAG-Tat R(49–57)A,binding
R20914 T26440 T26441 themeOf Tat,associates
R20915 T26440 T26444 themeOf Tat,binding
R20916 T26441 T26443 causeOf associates,increasing
R20917 T26442 T26441 themeOf p65,associates
R20918 T26444 T26443 themeOf binding,increasing
R21327 T27195 T27197 themeOf Tat,occupying
R21328 T27195 T27198 causeOf Tat,promoting
R21329 T27199 T27202 themeOf p65,displacement
R21330 T27199 T27200 themeOf p65,recruitment
R21331 T27200 T27198 themeOf recruitment,promoting
R21332 T27201 T27202 themeOf IκB-α,displacement
R21333 T27202 T27198 themeOf displacement,promoting
R21334 T27206 T27207 themeOf p65,interference
R21341 T27217 T27210 themeOf ACTB,expression
R22673 T29071 T29072 partOf NF-κB enhancer,MIP-1α
R22674 T29071 T29073 themeOf NF-κB enhancer,interacts
R22675 T29071 T29070 themeOf NF-κB enhancer,occupies
R22676 T29074 T29080 causeOf Tat,increasing
R22677 T29074 T29075 causeOf Tat,activates
R22678 T29074 T29078 causeOf Tat,removing
R22679 T29076 T29077 themeOf MIP-1α,expression
R22680 T29077 T29075 themeOf expression,activates
R22681 T29079 T29078 themeOf IκB-α,removing
R22682 T29081 T29080 themeOf binding,increasing
R22683 T29082 T29081 themeOf NF-κB enhancer,binding
R22684 T29082 T29076 partOf NF-κB enhancer,MIP-1α
R22685 T29082 T29079 partOf NF-κB enhancer,IκB-α
R22672 T29069 T29067 themeOf IκB-α,absence
R654 T46 T47 themeOf Tat,interaction
R655 T48 T47 themeOf IκB-α,interaction
R656 T50 T51 themeOf Tat,hijacking
R657 T53 T51 themeOf IκB-α,hijacking
R658 T53 T54 themeOf IκB-α,binding
R659 T53 T52 themeOf IκB-α,inhibitor
R660 T55 T58 causeOf Tat,increased
R661 T55 T56 themeOf Tat,associated
R662 T57 T56 themeOf p65,associated
R663 T59 T60 themeOf p65,binding
R664 T60 T58 themeOf binding,increased
R668 T65 T66 themeOf p65,association
R4306 T4881 T4880 equivalentTo TNF-α,tumor necrosis factor-α
R4889 T5664 T5663 themeOf p65,interference
R4890 T5665 T5663 themeOf IκB-α,interference
R5352 T6278 T6277 themeOf p65,Binding
R5353 T6279 T6277 themeOf p50,Binding
R5354 T6280 T6277 themeOf FLAG-Tat,Binding
R5698 T6702 T6705 themeOf HA-IκB-α,expressed
R5699 T6703 T6705 themeOf p65,expressed
R5700 T6704 T6705 themeOf Tat,expressed
R21335 T27211 T27210 themeOf MIP-1α,expression
R21336 T27212 T27210 themeOf CSF3,expression
R21337 T27213 T27210 themeOf LTA,expression
R21338 T27214 T27210 themeOf NFKBIA,expression
R21339 T27215 T27210 themeOf TLR2,expression
R21340 T27216 T27210 themeOf GAPDH,expression
R22120 T28234 T28235 causeOf Tat,enhances
R22121 T28234 T28238 themeOf Tat,interaction
R22122 T28236 T28237 themeOf MIP-1α,expression
R22123 T28237 T28235 themeOf expression,enhances
R22124 T28238 T28235 causeOf interaction,enhances
R22125 T28239 T28238 themeOf IκB-α,interaction
R22126 T28244 T28245 themeOf Tat,expression
R22127 T28248 T28247 themeOf p65,binding
R22128 T28255 T28256 themeOf MIP-1α,expression
R22668 T29064 T29065 themeOf MIP-1α,activation
R22669 T29066 T29065 causeOf Tat,activation
R22670 T29068 T29067 themeOf Tat,absence
R22671 T29069 T29070 themeOf IκB-α,occupies

bionlp-st-ge-2016-reference

Id Subject Object Predicate Lexical cue Negation Speculation
T97 64-75 Binding denotes interaction
T98 776-787 Binding denotes association
T99 866-876 Positive_regulation denotes responsive
T100 895-904 Positive_regulation denotes activated
T101 936-945 Positive_regulation denotes dependent
T102 916-926 Gene_expression denotes expression
T103 958-963 Binding denotes bound
T104 998-1007 Positive_regulation denotes promoting
T105 1012-1023 Binding denotes recruitment
T106 998-1007 Positive_regulation denotes promoting
T107 1036-1048 Binding denotes displacement true
T108 477-486 Binding denotes hijacking
T109 1220-1231 Binding denotes interaction
T110 514-524 Negative_regulation denotes preventing
T111 539-546 Binding denotes binding
T112 583-593 Binding denotes associated
T113 628-637 Positive_regulation denotes increased
T114 650-657 Binding denotes binding
T115 749-757 Positive_regulation denotes required
T116 749-757 Positive_regulation denotes required
T117 31-34 Protein denotes Tat
T118 762-767 Protein denotes IκB-α
T119 772-775 Protein denotes p65
T120 884-887 Protein denotes Tat
T121 932-935 Protein denotes p65
T122 971-977 Protein denotes MIP-1α
T123 1027-1030 Protein denotes p65
T124 1052-1057 Protein denotes IκB-α
T125 1121-1125 Protein denotes CSF3
T126 1127-1130 Protein denotes LTA
T127 81-86 Protein denotes IκB-α
T128 1132-1138 Protein denotes NFKBIA
T135 978-992 Entity denotes NF-κB enhancer
T136 501-506 Protein denotes IκB-α
T137 579-582 Protein denotes Tat
T138 603-606 Protein denotes p65
T139 642-645 Protein denotes p65
T140 740-743 Protein denotes Tat
T141 909-915 Protein denotes MIP-1α
T1250 1649-1652 Positive_regulation denotes for
T1251 1649-1652 Positive_regulation denotes for
T1252 1649-1652 Positive_regulation denotes for
T1253 1649-1652 Positive_regulation denotes for
T1254 1649-1652 Positive_regulation denotes for
T1255 1649-1652 Positive_regulation denotes for
T1256 1649-1652 Positive_regulation denotes for
T1257 1649-1652 Positive_regulation denotes for
T1258 1649-1652 Positive_regulation denotes for
T1259 1649-1652 Positive_regulation denotes for
T1260 1649-1652 Positive_regulation denotes for
T1261 1649-1652 Positive_regulation denotes for
T1262 1649-1652 Positive_regulation denotes for
T1263 1649-1652 Positive_regulation denotes for
T1264 1649-1652 Positive_regulation denotes for
T1265 1649-1652 Positive_regulation denotes for
T1266 1649-1652 Positive_regulation denotes for
T1267 1649-1652 Positive_regulation denotes for
T1268 1649-1652 Positive_regulation denotes for
T1269 1649-1652 Positive_regulation denotes for
T1270 1649-1652 Positive_regulation denotes for
T1271 1649-1652 Positive_regulation denotes for
T1272 1649-1652 Positive_regulation denotes for
T1273 1649-1652 Positive_regulation denotes for
T1274 1649-1652 Positive_regulation denotes for
T1275 1649-1652 Positive_regulation denotes for
T1276 1649-1652 Positive_regulation denotes for
T1277 1649-1652 Positive_regulation denotes for
T1278 1649-1652 Positive_regulation denotes for
T1279 1649-1652 Positive_regulation denotes for
T1280 1649-1652 Positive_regulation denotes for
T1281 1649-1652 Positive_regulation denotes for
T1282 1649-1652 Positive_regulation denotes for
T1283 1649-1652 Positive_regulation denotes for
T1284 1649-1652 Positive_regulation denotes for
T1285 1649-1652 Positive_regulation denotes for
T1286 1649-1652 Positive_regulation denotes for
T1287 1649-1652 Positive_regulation denotes for
T1288 1649-1652 Positive_regulation denotes for
T1289 1649-1652 Positive_regulation denotes for
T1290 1649-1652 Positive_regulation denotes for
T1291 1649-1652 Positive_regulation denotes for
T1292 1649-1652 Positive_regulation denotes for
T1293 1649-1652 Positive_regulation denotes for
T1294 1649-1652 Positive_regulation denotes for
T1295 1649-1652 Positive_regulation denotes for
T1296 1649-1652 Positive_regulation denotes for
T1297 1649-1652 Positive_regulation denotes for
T1298 1649-1652 Positive_regulation denotes for
T1299 1649-1652 Positive_regulation denotes for
T1300 1669-1681 Binding denotes dimerization
T1301 1669-1681 Binding denotes dimerization
T1302 1669-1681 Binding denotes dimerization
T1303 1669-1681 Binding denotes dimerization
T1304 1669-1681 Binding denotes dimerization
T1305 1690-1697 Binding denotes binding
T1306 1690-1697 Binding denotes binding
T1307 1690-1697 Binding denotes binding
T1308 1690-1697 Binding denotes binding
T1309 1690-1697 Binding denotes binding
T1310 1867-1870 Protein denotes p65
T1311 1872-1876 Protein denotes RelB
T1312 1881-1886 Protein denotes c-Rel
T1313 2249-2254 Protein denotes IκB-α
T1314 2301-2315 Phosphorylation denotes phosphorylated
T1315 2301-2315 Phosphorylation denotes phosphorylated
T1316 2326-2331 Entity denotes Ser32
T1317 2336-2341 Entity denotes Ser36
T1318 2364-2377 Ubiquitination denotes ubiquitylated
T1319 2364-2377 Ubiquitination denotes ubiquitylated
T1320 2381-2386 Entity denotes Lys21
T1321 2391-2396 Entity denotes Lys22
T1322 2403-2411 Protein_catabolism denotes degraded
T1323 2412-2414 Positive_regulation denotes by
T1324 2473-2488 Phosphorylation denotes phosphorylation
T1325 2473-2488 Phosphorylation denotes phosphorylation
T1326 2473-2488 Phosphorylation denotes phosphorylation
T1327 2492-2495 Protein denotes p65
T1328 2499-2505 Entity denotes Ser276
T1329 2506-2508 Positive_regulation denotes by
T1330 2517-2521 Protein denotes MSK1
T1331 2529-2535 Entity denotes Ser311
T1332 2536-2538 Positive_regulation denotes by
T1333 2539-2543 Protein denotes PKCζ
T1334 2552-2558 Entity denotes Ser536
T1335 2559-2561 Positive_regulation denotes by
T1336 2562-2566 Protein denotes IKKα
T1337 2576-2587 Acetylation denotes Acetylation
T1338 2576-2587 Acetylation denotes Acetylation
T1339 2591-2594 Protein denotes p65
T1340 2598-2604 Entity denotes Lys218
T1341 2609-2615 Entity denotes Lys221
T1342 2616-2625 Positive_regulation denotes increases
T1343 2616-2625 Positive_regulation denotes increases
T1359 3011-3022 Deacetylation denotes acetylation
T1360 3011-3022 Deacetylation denotes acetylation
T1361 3026-3029 Protein denotes p65
T1362 3033-3039 Entity denotes Lys122
T1363 3044-3050 Entity denotes Lys123
T1364 3810-3817 Binding denotes binding
T1365 3825-3830 Protein denotes gp120
T1366 3849-3852 Protein denotes CD4
T1367 3853-3860 Positive_regulation denotes induces
T1368 3883-3893 Positive_regulation denotes activation
T1369 3910-3922 Protein denotes procaspase 8
T1370 3982-3985 Protein denotes Tat
T1371 3994-4003 Binding denotes interacts
T1372 4079-4082 Protein denotes Tat
T1373 4083-4088 Binding denotes binds
T1374 4231-4254 Protein denotes tumor necrosis factor β
T1375 4256-4260 Protein denotes TNFβ
T1376 4271-4284 Protein denotes interleukin-6
T1377 4286-4290 Protein denotes IL-6
T1378 4300-4308 Positive_regulation denotes activate
T1379 4300-4308 Positive_regulation denotes activate
T1380 4314-4327 Transcription denotes transcription
T1381 4314-4327 Transcription denotes transcription
T1382 4337-4340 Protein denotes Tat
T1383 4399-4410 Binding denotes interacting
T1384 4399-4410 Binding denotes interacting
T1385 4399-4410 Binding denotes interacting
T1386 4399-4410 Binding denotes interacting
T1387 4399-4410 Binding denotes interacting
T1388 4399-4410 Binding denotes interacting
T1389 4399-4410 Binding denotes interacting
T1390 4399-4410 Binding denotes interacting
T1391 4399-4410 Binding denotes interacting
T1392 4459-4462 Protein denotes Sp1
T1393 4469-4474 Protein denotes TFIID
T1394 4481-4486 Protein denotes E2F-4
T1395 4493-4499 Protein denotes C/EBPβ
T1396 4506-4515 Protein denotes cyclin T1
T1397 4516-4520 Protein denotes CDK9
T1398 4564-4568 Protein denotes p300
T1399 4569-4572 Protein denotes CBP
T1400 4577-4582 Protein denotes P/CAF
T1401 4597-4605 Localization denotes released
T1402 4633-4636 Protein denotes Tat
T1403 4671-4678 Binding denotes binding
T1404 4722-4739 Protein denotes Flk1/KDR receptor
T1405 4858-4867 Gene_expression denotes expressed
T1406 4872-4875 Protein denotes Tat
T1407 4940-4943 Protein denotes Tat
T1408 4944-4951 Positive_regulation denotes induced
T1409 4985-4996 Protein_catabolism denotes degradation
T1410 5000-5005 Protein denotes IκB-α
T1411 5030-5033 Protein denotes p65
T1412 5062-5072 Negative_regulation denotes inhibiting
T1413 5077-5083 Protein denotes SIRT-1
T1414 5084-5092 Positive_regulation denotes mediated
T1415 5093-5106 Deacetylation denotes deacetylation
T1416 5110-5113 Protein denotes p65
T1417 5114-5120 Entity denotes Lys310
T1418 5157-5160 Protein denotes Tat
T1419 5244-5247 Protein denotes Tat
T1420 5331-5340 Gene_expression denotes synthesis
T1421 5344-5349 Protein denotes IκB-α
T1422 5384-5389 Protein denotes IκB-α
T1423 5390-5395 Binding denotes binds
T1424 5399-5402 Protein denotes Tat
T1425 5502-5505 Protein denotes Tat
T1426 5571-5582 Binding denotes interaction
T1427 5588-5593 Protein denotes IκB-α
T1428 5598-5601 Protein denotes p65
T6998 11934-11937 Protein denotes Tat
T6999 11942-11948 Protein denotes MIP-1α
T7000 12000-12004 Protein denotes CSF3
T7001 12006-12009 Protein denotes LTA
T7002 12011-12017 Protein denotes NFKBIA
T7003 12019-12023 Protein denotes TLR2
T7004 12025-12030 Protein denotes GAPDH
T7005 12035-12039 Protein denotes ACTB
T7006 12242-12247 Protein denotes GAPDH
T8422 15609-15618 Positive_regulation denotes increased
T8423 15697-15712 Negative_regulation denotes barely detected
T8424 15716-15725 Protein denotes siRNA Tat
T8425 15765-15774 Positive_regulation denotes dependent
T8426 15775-15785 Protein denotes luciferase
T8427 15786-15796 Gene_expression denotes expression
T8428 15820-15827 Positive_regulation denotes induced
T8429 15943-15952 Protein denotes siRNA Tat
T8430 15992-15995 Protein denotes Tat
T8431 17304-17307 Protein denotes p65
T8432 17308-17311 Protein denotes p50
T8433 17312-17319 Binding denotes binding true
T8434 17312-17319 Binding denotes binding true
T8435 17382-17385 Protein denotes p65
T8436 17457-17460 Protein denotes Tat
T8437 17502-17505 Protein denotes Tat
T8438 17516-17525 Protein denotes siRNA Tat
T8439 17571-17574 Protein denotes p65
T8440 17579-17586 Binding denotes binding
T8441 17599-17602 Protein denotes p65
T8442 17613-17621 Positive_regulation denotes elevated
T8443 17613-17621 Positive_regulation denotes elevated
T8444 17637-17640 Protein denotes Tat
T8445 17682-17689 Negative_regulation denotes dropped
T8446 17682-17689 Negative_regulation denotes dropped
T8447 17693-17700 Negative_regulation denotes absence
T8448 17704-17707 Protein denotes Tat
T8449 17709-17718 Protein denotes siRNA Tat
T8450 17739-17744 Protein denotes IκB-α
T8451 17749-17757 Protein_catabolism denotes degraded
T8452 17811-17822 Gene_expression denotes synthesized
T8453 17885-17888 Protein denotes Tat
T8454 17902-17905 Protein denotes Tat
T8455 18078-18081 Protein denotes Tat
T8456 18150-18155 Protein denotes IκB-α
T8457 18156-18167 Protein_catabolism denotes degradation
T8458 18168-18180 Gene_expression denotes re-synthesis
T8459 18186-18194 Positive_regulation denotes observed
T8485 19380-19388 Positive_regulation denotes elevated
T8486 19418-19421 Protein denotes Tat
T8487 19443-19450 Negative_regulation denotes dropped
T8488 19443-19450 Negative_regulation denotes dropped
T8489 19454-19457 Protein denotes Tat
T8490 19458-19466 Negative_regulation denotes negative
T8491 19505-19508 Protein denotes Tat
T8492 19509-19514 Binding denotes bound
T8493 19575-19582 Binding denotes binding
T8494 19583-19592 Positive_regulation denotes increased
T8495 19717-19728 Protein_catabolism denotes Degradation
T8496 19732-19737 Protein denotes IκB-α
T8497 19756-19763 Positive_regulation denotes induced
T8498 19777-19785 Positive_regulation denotes followed
T8499 19797-19806 Gene_expression denotes synthesis
T8500 19860-19863 Protein denotes Tat
T8501 20023-20026 Protein denotes Tat
T8502 20069-20072 Protein denotes Tat
T8503 20151-20160 Regulation denotes affecting true
T8504 20182-20187 Protein denotes IκB-α
T8505 21841-21844 Protein denotes Tat
T8506 21845-21850 Binding denotes binds
T8507 21858-21871 Entity denotes sixth ankyrin
T8508 21875-21880 Protein denotes IκB-α
T8509 21908-21911 Protein denotes Tat
T8510 21912-21924 Negative_regulation denotes counteracted true
T8511 21929-21939 Binding denotes generation
T8512 21947-21952 Protein denotes IκB-α
T8513 21985-21996 Binding denotes association true
T8514 22000-22005 Protein denotes IκB-α
T8515 22011-22014 Protein denotes p65
T8516 22162-22171 Gene_expression denotes synthesis
T8517 22175-22180 Protein denotes IκB-α
T8518 22196-22217 Binding denotes Coimmunoprecipitation
T8519 22221-22226 Protein denotes IκB-α
T8520 22232-22235 Protein denotes p65
T8521 22285-22288 Protein denotes Tat
T8522 22340-22346 Negative_regulation denotes halved
T8523 22350-22353 Protein denotes Tat
T8524 22376-22379 Protein denotes Tat
T8525 22380-22400 Binding denotes coimmunoprecipitated
T8526 22406-22411 Protein denotes IκB-α
T8527 22456-22459 Protein denotes Tat
T8528 22460-22468 Negative_regulation denotes competed
T8529 22473-22478 Protein denotes IκB-α
T8530 22479-22486 Binding denotes binding
T8531 22490-22493 Protein denotes p65
T11511 22496-22499 Protein denotes Tat
T11512 22500-22511 Negative_regulation denotes counteracts
T11513 22516-22521 Protein denotes IκB-α
T11514 22522-22532 Negative_regulation denotes inhibition
T11515 22536-22539 Protein denotes p65
T11516 22543-22552 Negative_regulation denotes competing
T11517 22567-22574 Binding denotes binding
T11518 22612-22623 Binding denotes interaction
T11519 22627-22630 Protein denotes Tat
T11520 22636-22641 Protein denotes IκB-α
T11521 22769-22772 Protein denotes Tat
T11522 22782-22797 Protein denotes Tat T,N(23,24)A
T11523 22799-22815 Protein denotes Tat C(22,25,27)A
T11524 22817-22830 Protein denotes Tat K(50,51)A
T11525 22835-22848 Protein denotes Tat R(49–57)A
T11533 23011-23019 Positive_regulation denotes involved
T11534 23027-23034 Binding denotes binding
T11535 23038-23043 Protein denotes IκB-α
T11536 23112-23115 Protein denotes Tat
T11537 23116-23127 Binding denotes associating
T11538 23133-23138 Protein denotes IκB-α
T11539 23139-23147 Negative_regulation denotes competed
T11540 23152-23159 Binding denotes binding
T11541 23163-23168 Protein denotes IκB-α
T11542 23172-23175 Protein denotes p65
T11543 23233-23246 Protein denotes Tat R(49–57)A
T11544 23254-23260 Negative_regulation denotes lacked
T11545 23265-23272 Binding denotes binding
T11546 23273-23277 Entity denotes site
T11547 23282-23287 Protein denotes IκB-α
T11548 23297-23306 Binding denotes associate true
T11549 23312-23317 Protein denotes IκB-α
T11550 23330-23337 Negative_regulation denotes compete true
T11551 23342-23349 Binding denotes binding
T11552 23353-23358 Protein denotes IκB-α
T11553 23362-23365 Protein denotes p65
T11554 25511-25514 Protein denotes Tat
T11555 25515-25527 Negative_regulation denotes counteracted true
T11556 25532-25537 Protein denotes IκB-α
T11557 25547-25557 Negative_regulation denotes inhibition
T11558 25561-25564 Protein denotes p65
T11559 25565-25572 Binding denotes binding
T11560 25614-25617 Protein denotes p65
T11561 25622-25627 Protein denotes IκB-α
T11562 25684-25687 Protein denotes Tat
T11563 25710-25713 Protein denotes p65
T11564 25718-25725 Binding denotes binding
T11565 25739-25748 Negative_regulation denotes inhibited
T11566 25752-25757 Protein denotes IκB-α
T11567 25762-25770 Negative_regulation denotes restored true
T11568 25762-25770 Negative_regulation denotes restored true
T11569 25811-25814 Protein denotes Tat
T11570 25827-25839 Protein denotes Tat R(49–57)
T11571 25878-25881 Protein denotes Tat
T11572 25896-25901 Protein denotes IκB-α
T11573 25916-25919 Protein denotes p65
T11574 25961-25964 Protein denotes p50
T11575 25967-25970 Protein denotes p65
T11576 25993-25996 Protein denotes Luc
T11577 26042-26045 Protein denotes p65
T11578 26050-26055 Protein denotes IκB-α
T11579 26083-26086 Protein denotes Tat
T11580 26088-26093 Protein denotes IκB-α
T11581 26094-26103 Negative_regulation denotes inhibited
T11582 26108-26111 Protein denotes p65
T11583 26112-26121 Positive_regulation denotes dependent
T11584 26122-26132 Gene_expression denotes expression
T11585 26140-26150 Protein denotes luciferase
T11586 26167-26175 Negative_regulation denotes restored true
T11587 26167-26175 Negative_regulation denotes restored true
T11588 26216-26219 Protein denotes Tat
T11589 26232-26245 Protein denotes Tat R(49–57)A
T11590 26299-26302 Protein denotes Tat
T11591 26303-26314 Negative_regulation denotes counteracts
T11592 26303-26314 Negative_regulation denotes counteracts
T11593 26319-26324 Protein denotes IκB-α
T11594 26325-26335 Negative_regulation denotes repression
T11595 26343-26346 Protein denotes p65
T11596 26351-26358 Binding denotes binding
T11597 26391-26402 Binding denotes associating
T11598 26408-26413 Protein denotes IκB-α
T11599 26418-26427 Negative_regulation denotes competing
T11600 26442-26449 Binding denotes binding
T11601 26453-26456 Protein denotes p65
T13251 26647-26653 Protein denotes HA-p65
T13252 26658-26666 Protein denotes FLAG-Tat
T13253 26683-26686 Protein denotes Tat
T13254 26691-26709 Gene_expression denotes immunoprecipitated
T13255 26734-26737 Protein denotes p65
T13256 26750-26770 Binding denotes coimmunoprecipitated
T13257 26786-26789 Protein denotes Tat
T13258 26805-26820 Protein denotes Tat T,N(23,24)A
T13259 26822-26835 Protein denotes Tat K(50,51)A
T13260 26840-26853 Protein denotes Tat R(49–57)A
T13261 26893-26901 Negative_regulation denotes decrease
T13262 26905-26926 Binding denotes coimmunoprecipitation
T13263 26944-26960 Protein denotes Tat C(22,25,27)A
T13264 26988-26991 Protein denotes GST
T13265 27052-27059 Binding denotes binding
T13266 27063-27066 Protein denotes p65
T13267 27080-27083 Protein denotes Tat
T13283 29182-29190 Protein denotes FLAG-Tat
T13284 29205-29211 Protein denotes HA-p65
T13285 29232-29239 Negative_regulation denotes deleted
T13286 29232-29239 Negative_regulation denotes deleted
T13287 29247-29269 Entity denotes transactivation domain
T13288 29271-29284 Protein denotes p65ΔC (1–318)
T13289 29294-29297 Entity denotes RHD
T13290 29299-29314 Protein denotes p65ΔN (122–551)
T13291 29329-29332 Protein denotes Tat
T13292 29333-29353 Binding denotes coimmunoprecipitated true
T13293 29359-29372 Protein denotes p65ΔC (1–318)
T13294 29387-29402 Protein denotes p65ΔN (122–551)
T13295 29436-29439 Entity denotes RHD
T13296 29443-29446 Protein denotes p65
T13297 29476-29487 Binding denotes interaction
T13298 29493-29496 Protein denotes Tat
T13299 29513-29519 Regulation denotes effect true
T13300 29523-29526 Protein denotes Tat
T13301 29534-29537 Protein denotes p65
T13302 29542-29549 Binding denotes binding
T13303 29581-29584 Protein denotes p65
T13304 29698-29701 Protein denotes Tat
T13305 29705-29721 Protein denotes Tat C(22,25,27)A
T13306 29727-29730 Protein denotes p65
T13307 29735-29742 Binding denotes binding true
T13308 29783-29786 Protein denotes Tat
T13309 29801-29810 Positive_regulation denotes increased
T13310 29815-29822 Binding denotes binding
T13311 29826-29829 Protein denotes p65
T13312 29849-29865 Protein denotes Tat C(22,25,27)A
T13313 29867-29874 Negative_regulation denotes lacking
T13314 29879-29886 Binding denotes binding
T13315 29887-29891 Entity denotes site
T13316 29896-29899 Protein denotes p65
T13317 29905-29916 Positive_regulation denotes ineffective true
T13318 29934-29937 Protein denotes p65
T13319 29938-29945 Binding denotes binding true
T13320 30066-30069 Protein denotes Tat
T13321 30084-30092 Positive_regulation denotes enhanced
T13322 30097-30100 Protein denotes p65
T13323 30110-30117 Binding denotes binding
T15079 30145-30148 Protein denotes Tat
T15080 30163-30166 Protein denotes p65
T15081 30215-30223 Binding denotes occupies
T15082 30248-30256 Positive_regulation denotes promotes
T15083 30248-30256 Positive_regulation denotes promotes
T15084 30261-30264 Protein denotes p65
T15085 30265-30276 Binding denotes recruitment
T15086 30282-30287 Protein denotes IκB-α
T15087 30288-30300 Binding denotes displacement true
T15088 30327-30330 Protein denotes Tat
T15089 30430-30438 Protein denotes FLAG-Tat
T15090 30440-30461 Protein denotes FLAG-Tat C(22,25,27)A
T15091 30465-30483 Protein denotes FLAG-Tat R(49–57)A
T15092 30583-30586 Protein denotes Tat
T15093 30601-30610 Positive_regulation denotes increased
T15094 30601-30610 Positive_regulation denotes increased
T15095 30601-30610 Positive_regulation denotes increased
T15096 30601-30610 Positive_regulation denotes increased
T15097 30601-30610 Positive_regulation denotes increased
T15098 30615-30625 Gene_expression denotes expression
T15099 30615-30625 Gene_expression denotes expression
T15100 30615-30625 Gene_expression denotes expression
T15101 30615-30625 Gene_expression denotes expression
T15102 30615-30625 Gene_expression denotes expression
T15103 30629-30635 Protein denotes MIP-1α
T15104 30637-30641 Protein denotes CSF3
T15105 30643-30646 Protein denotes LTA
T15106 30648-30654 Protein denotes NFKBIA
T15107 30659-30663 Protein denotes TLR2
T15108 30683-30699 Protein denotes Tat C(22,25,27)A
T15109 30704-30717 Protein denotes Tat R(49–57)A
T15110 30723-30734 Positive_regulation denotes ineffective true
T15111 30723-30734 Positive_regulation denotes ineffective true
T15112 30723-30734 Positive_regulation denotes ineffective true
T15113 30723-30734 Positive_regulation denotes ineffective true
T15114 30723-30734 Positive_regulation denotes ineffective true
T15115 30723-30734 Positive_regulation denotes ineffective true
T15116 30723-30734 Positive_regulation denotes ineffective true
T15117 30723-30734 Positive_regulation denotes ineffective true
T15118 30723-30734 Positive_regulation denotes ineffective true
T15119 30723-30734 Positive_regulation denotes ineffective true
T15120 30754-30757 Protein denotes Tat
T15121 30860-30869 Protein denotes siRNA p65
T15122 30891-30894 Protein denotes Tat
T15123 30938-30941 Protein denotes p65
T15124 31016-31021 Protein denotes GAPDH
T15125 31026-31030 Protein denotes ACTB
T15126 31063-31066 Protein denotes Tat
T15127 31200-31203 Protein denotes Tat
T15128 31298-31301 Protein denotes Tat
T15129 31331-31342 Binding denotes interaction
T15130 31369-31372 Protein denotes p65
T15131 31377-31382 Protein denotes IκB-α
T15132 32978-32984 Protein denotes MIP-1α
T15133 33007-33016 Positive_regulation denotes activated
T15134 33025-33028 Protein denotes Tat
T15135 33148-33154 Protein denotes MIP-1α
T15136 33155-33165 Gene_expression denotes expression
T15137 33170-33179 Positive_regulation denotes increased
T15138 33247-33253 Protein denotes MIP-1α
T15139 33254-33264 Gene_expression denotes production
T15140 33269-33276 Positive_regulation denotes induced
T15141 33308-33311 Protein denotes Tat
T15142 33336-33351 Transcription denotes transcriptional
T15145 33535-33541 Protein denotes MIP-1α
T15146 33723-33729 Protein denotes MIP-1α
T15147 33770-33775 Protein denotes TNF-α
T15148 33822-33832 Gene_expression denotes expression true
T15149 33843-33849 Protein denotes MIP-1α
T15150 33876-33879 Protein denotes p65
T15151 33880-33889 Binding denotes occupancy true
T15152 33897-33908 Entity denotes NF-κB sites
T15153 33918-33923 Protein denotes TNF-α
T15154 33924-33933 Positive_regulation denotes activated
T15155 33938-33948 Gene_expression denotes expression
T15156 33952-33958 Protein denotes MIP-1α
T15157 33963-33970 Positive_regulation denotes induced
T15158 33975-33978 Protein denotes p65
T15159 33979-33990 Binding denotes recruitment
T15160 33998-34009 Entity denotes NF-κB1 site
T15161 34013-34019 Protein denotes MIP-1α
T15162 34028-34037 Positive_regulation denotes affecting true
T15163 34042-34051 Binding denotes occupancy
T15164 34128-34131 Protein denotes Tat
T15165 34137-34145 Positive_regulation denotes promoted
T15166 34150-34161 Binding denotes recruitment
T15167 34165-34168 Protein denotes p65
T15168 34176-34187 Entity denotes NF-κB1 site
T15169 34191-34197 Protein denotes MIP-1α
T15170 34389-34395 Protein denotes MIP-1α
T15171 34420-34425 Protein denotes TNF-α
T15172 34430-34433 Protein denotes Tat
T15173 34448-34454 Protein denotes MIP-1α
T15174 34456-34459 Protein denotes Tat
T15175 34460-34469 Positive_regulation denotes increased
T15176 34460-34469 Positive_regulation denotes increased
T15177 34460-34469 Positive_regulation denotes increased
T15178 34460-34469 Positive_regulation denotes increased
T15179 34474-34485 Binding denotes recruitment
T15180 34474-34485 Binding denotes recruitment
T15181 34474-34485 Binding denotes recruitment
T15182 34474-34485 Binding denotes recruitment
T15183 34489-34492 Protein denotes p65
T15184 34500-34515 Entity denotes NF-κB enhancers
T15185 34519-34523 Protein denotes CSF3
T15186 34525-34528 Protein denotes LTA
T15187 34530-34536 Protein denotes NFKBIA
T15188 34541-34545 Protein denotes TLR2
T15189 34560-34571 Positive_regulation denotes ineffective true
T15190 34560-34571 Positive_regulation denotes ineffective true
T15191 34579-34588 Entity denotes promoters
T15192 34592-34597 Protein denotes GAPDH
T15193 34602-34606 Protein denotes ACTB
T15194 34629-34632 Protein denotes Tat
T15195 34633-34638 Binding denotes bound true
T15196 34689-34694 Protein denotes GAPDH
T15197 34699-34703 Protein denotes ACTB
T15198 34704-34713 Entity denotes promoters
T15199 34720-34724 Negative_regulation denotes loss
T15200 34746-34749 Protein denotes p65
T15201 34754-34766 Negative_regulation denotes interference
T15202 34796-34799 Protein denotes Tat
T15203 34800-34809 Binding denotes occupancy
T15204 34819-34822 Positive_regulation denotes via true
T15205 34823-34826 Protein denotes p65
T15206 34827-34838 Binding denotes interaction true
T15207 34864-34869 Protein denotes IκB-α
T15208 34874-34902 Binding denotes chromatin-immunoprecipitated
T15209 34940-34943 Protein denotes Tat
T15210 34970-34977 Negative_regulation denotes removed
T15211 34970-34977 Negative_regulation denotes removed
T15212 34993-34996 Protein denotes Tat
T15213 35011-35016 Protein denotes IκB-α
T15214 35021-35033 Negative_regulation denotes interference
T15215 35063-35066 Protein denotes Tat
T15216 35067-35076 Negative_regulation denotes displaced
T15217 35077-35082 Protein denotes IκB-α
T15218 35083-35087 Binding denotes from
T17708 35214-35216 Positive_regulation denotes by
T17709 35217-35228 Binding denotes interacting
T17710 35234-35239 Protein denotes IκB-α
T17711 35244-35247 Protein denotes p65
T17712 35273-35276 Protein denotes Tat
T17713 35277-35285 Regulation denotes affected true
T17714 35313-35323 Gene_expression denotes expression
T17715 35327-35333 Protein denotes MIP-1α
T17716 35382-35385 Protein denotes Tat
T17717 35412-35415 Protein denotes Env
T17718 35434-35442 Protein denotes FLAG-Tat
T17719 35565-35574 Protein denotes siRNA Tat
T17720 35615-35623 Regulation denotes modulate
T17721 35628-35631 Protein denotes Tat
T17722 35632-35642 Gene_expression denotes expression
T17723 35729-35739 Gene_expression denotes expression
T17724 35729-35739 Gene_expression denotes expression
T17725 35743-35746 Protein denotes Tat
T17726 35751-35754 Protein denotes p24
T17727 35818-35826 Negative_regulation denotes detected
T17728 35818-35826 Negative_regulation denotes detected
T17729 35830-35839 Protein denotes siRNA Tat
T17730 38161-38164 Protein denotes p65
T17731 38169-38176 Binding denotes binding
T17732 38182-38189 Positive_regulation denotes induced
T17733 38220-38223 Protein denotes Tat
T17734 38266-38269 Protein denotes Tat
T17735 38286-38295 Protein denotes siRNA Tat
T17736 38302-38311 Positive_regulation denotes increased
T17737 38328-38331 Protein denotes Tat
T17738 38360-38371 Protein_catabolism denotes Degradation
T17739 38375-38380 Protein denotes IκB-α
T17740 38425-38433 Positive_regulation denotes followed
T17741 38445-38454 Gene_expression denotes synthesis
T17742 38458-38463 Protein denotes IκB-α
T17743 38472-38485 Regulation denotes independently true
T17744 38493-38496 Protein denotes Tat
T17745 38628-38631 Protein denotes Tat
T17746 38928-38931 Protein denotes Tat
T17747 38936-38956 Binding denotes coimmunoprecipitated
T17748 38962-38967 Protein denotes IκB-α
T17749 38972-38975 Protein denotes p65
T17750 38993-39002 Positive_regulation denotes activated
T17751 39007-39013 Protein denotes MIP-1α
T17752 39014-39024 Gene_expression denotes expression
T17753 39030-39033 Protein denotes p65
T17754 39034-39043 Positive_regulation denotes dependent
T17755 39068-39072 Negative_regulation denotes lack
T17756 39083-39092 Positive_regulation denotes following
T17757 39113-39116 Protein denotes Tat
T17758 39120-39123 Protein denotes p65
T17759 39147-39150 Protein denotes Tat
T17760 39155-39158 Protein denotes p65
T17761 39169-39178 Binding denotes recruited
T17762 39186-39200 Entity denotes NF-κB enhancer
T17763 39204-39210 Protein denotes MIP-1α
T17764 39222-39225 Protein denotes p65
T17765 39226-39235 Binding denotes occupancy
T17766 39240-39249 Negative_regulation denotes abolished
T17767 39253-39262 Protein denotes siRNA Tat
T17768 39354-39357 Protein denotes Tat
T17769 39358-39368 Binding denotes associated
T17770 39374-39379 Protein denotes IκB-α
T17771 39384-39387 Protein denotes p65
T17772 39393-39400 Positive_regulation denotes induced
T17773 39405-39408 Protein denotes p65
T17774 39419-39429 Positive_regulation denotes activation
T17775 39433-39439 Protein denotes MIP-1α
T17776 39440-39450 Gene_expression denotes expression
T17777 39459-39468 Binding denotes occupancy
T17778 39476-39482 Protein denotes MIP-1α
T17779 39483-39491 Entity denotes promoter
T17780 39496-39505 Positive_regulation denotes increased
T17781 39506-39517 Binding denotes recruitment
T17782 39521-39524 Protein denotes p65
T19671 39897-39900 Protein denotes p65
T19672 40006-40013 Negative_regulation denotes silence true
T19673 40018-40021 Protein denotes Tat
T19674 40022-40032 Gene_expression denotes expression
T19675 40283-40288 Protein denotes IκB-α
T19676 40289-40300 Protein_catabolism denotes degradation
T19677 40308-40315 Negative_regulation denotes absence
T19678 40319-40322 Protein denotes Tat
T19679 40372-40381 Gene_expression denotes synthesis
T19680 40385-40390 Protein denotes IκB-α
T19681 40448-40451 Protein denotes Tat
T19682 40486-40495 Negative_regulation denotes silencing
T19683 40503-40506 Protein denotes Tat
T19684 40575-40578 Protein denotes Tat
T19685 40615-40624 Regulation denotes affecting true
T19686 40663-40668 Protein denotes IκB-α
T19687 40742-40745 Protein denotes Tat
T19688 40776-40779 Protein denotes Tat
T19689 40849-40860 Gene_expression denotes synthesized
T19690 40861-40866 Protein denotes IκB-α
T19691 40872-40875 Protein denotes Tat
T19692 40926-40937 Binding denotes association
T19693 40964-40969 Protein denotes IκB-α
T19694 40977-40987 Negative_regulation denotes interfered
T19695 40997-41007 Binding denotes generation
T19696 41015-41020 Protein denotes IκB-α
T19697 41021-41024 Protein denotes p65
T19698 41066-41069 Protein denotes Tat
T19699 41070-41078 Negative_regulation denotes competed
T19700 41087-41094 Binding denotes binding
T19701 41098-41103 Protein denotes IκB-α
T19702 41107-41110 Protein denotes p65
T19703 41115-41124 Negative_regulation denotes prevented
T19704 41129-41134 Protein denotes IκB-α
T19705 41135-41145 Negative_regulation denotes repression
T19706 41149-41152 Protein denotes p65
T19707 41199-41202 Protein denotes Tat
T19708 41203-41213 Binding denotes associated
T19709 41219-41222 Protein denotes p65
T19710 41227-41236 Positive_regulation denotes increased
T19711 41241-41244 Protein denotes p65
T19712 41245-41252 Binding denotes binding
T19713 41358-41366 Positive_regulation denotes stronger
T19714 41367-41374 Binding denotes binding
T19715 41378-41381 Protein denotes p65
T19716 41395-41406 Positive_regulation denotes consequence
T19717 41417-41428 Binding denotes association
T19718 41434-41437 Protein denotes Tat
T19719 41452-41458 Positive_regulation denotes caused true
T19720 41476-41482 Regulation denotes change
T19721 41486-41489 Protein denotes p65
T19722 41521-41524 Protein denotes Tat
T19723 41525-41547 Entity denotes cysteine-rich sequence
T19724 41564-41572 Positive_regulation denotes involved
T19725 41580-41587 Binding denotes binding
T19726 41595-41598 Entity denotes RHD
T19727 41602-41605 Protein denotes p65
T19728 41645-41648 Protein denotes Tat
T19729 41649-41671 Entity denotes arginine-rich sequence
T19730 41697-41705 Positive_regulation denotes required
T19731 41697-41705 Positive_regulation denotes required
T19732 41714-41721 Binding denotes binding
T19733 41729-41742 Entity denotes sixth ankyrin
T19734 41746-41751 Protein denotes IκB-α
T19735 41769-41778 Negative_regulation denotes releasing
T19736 41779-41782 Protein denotes p65
T19737 41792-41797 Protein denotes IκB-α
T19738 41798-41808 Negative_regulation denotes inhibition
T19739 41853-41856 Protein denotes Tat
T19740 41912-41921 Binding denotes hijacking
T19741 41926-41931 Protein denotes IκB-α
T19742 41943-41952 Negative_regulation denotes shielding
T19743 41953-41956 Protein denotes p65
T19744 41966-41971 Protein denotes IκB-α
T19745 41972-41979 Binding denotes embrace
T19746 41985-41994 Positive_regulation denotes enforcing
T19747 41999-42002 Protein denotes p65
T19748 42003-42010 Binding denotes binding
T19749 42039-42042 Protein denotes Tat
T19750 42085-42088 Protein denotes Tat
T19751 42102-42113 Protein denotes Tat mutants
T19752 42247-42253 Protein denotes MIP-1α
T19753 42255-42259 Protein denotes CSF3
T19754 42261-42264 Protein denotes LTA
T19755 42266-42272 Protein denotes NFKBIA
T19756 42277-42281 Protein denotes TLR2
T19757 42318-42321 Protein denotes Tat
T19758 42322-42331 Positive_regulation denotes increased
T19759 42336-42347 Binding denotes recruitment
T19760 42351-42354 Protein denotes p65
T19761 42410-42419 Binding denotes recovered
T19762 42443-42455 Negative_regulation denotes interference
T19763 42459-42462 Protein denotes p65
T19764 42463-42472 Negative_regulation denotes abolished
T19765 42477-42480 Protein denotes Tat
T19766 42481-42490 Binding denotes occupancy
T19767 42534-42537 Protein denotes Tat
T19768 42538-42545 Binding denotes binding
T19769 42569-42577 Positive_regulation denotes mediated
T19770 42581-42584 Protein denotes p65
T19771 42639-42642 Protein denotes Tat
T19772 42643-42652 Negative_regulation denotes displaced
T19773 42653-42656 Protein denotes p65
T19774 42666-42673 Binding denotes binding
T19775 42677-42682 Protein denotes IκB-α
T19776 42708-42717 Positive_regulation denotes increased
T19777 42722-42725 Protein denotes p65
T19778 42730-42737 Binding denotes binding
T19779 42755-42766 Binding denotes association
T19780 42792-42795 Protein denotes Tat
T19781 42803-42812 Positive_regulation denotes increased true
T19782 42803-42812 Positive_regulation denotes increased true
T19783 42817-42828 Binding denotes recruitment
T19784 42832-42835 Protein denotes p65
T19785 42872-42883 Binding denotes associating
T19786 42889-42892 Protein denotes p65
T19787 42900-42911 Negative_regulation denotes interfering
T19788 42921-42929 Binding denotes assembly
T19789 42933-42936 Protein denotes p65
T19790 42956-42961 Protein denotes IκB-α
T19791 42976-42981 Protein denotes IκB-α
T19792 42986-42991 Negative_regulation denotes found true
T19793 42992-43002 Binding denotes associated
T19794 43029-43036 Negative_regulation denotes absence
T19795 43040-43043 Protein denotes Tat
T19796 43083-43086 Protein denotes Tat
T19797 43140-43145 Protein denotes IκB-α
T19798 43173-43182 Binding denotes occupancy
T19799 43214-43219 Protein denotes IκB-α
T19800 43230-43240 Binding denotes associated
T19801 43267-43269 Binding denotes at
T19802 43274-43278 Protein denotes hes1
T19803 43279-43287 Entity denotes promoter
T19804 43307-43314 Binding denotes removed true
T19805 43315-43324 Positive_regulation denotes following
T19806 43325-43330 Protein denotes TNF-α
T19807 43343-43350 Positive_regulation denotes causing
T19808 43375-43379 Protein denotes hes1
T19809 43380-43406 Positive_regulation denotes transcriptional activation
T19810 43523-43526 Protein denotes Tat
T19811 43562-43564 Positive_regulation denotes by
T19812 43562-43564 Positive_regulation denotes by
T19813 43565-43573 Binding denotes removing true
T19814 43574-43579 Protein denotes IκB-α
T19815 43584-43593 Positive_regulation denotes promoting
T19816 43598-43601 Protein denotes p65
T19817 43602-43609 Binding denotes loading
T19818 44076-44079 Protein denotes Tat
T19819 44080-44090 Regulation denotes cross talk
T19820 44182-44185 Protein denotes Tat
T19821 44287-44290 Protein denotes Tat
T19822 44324-44329 Protein denotes IκB-α
T19823 44336-44357 Binding denotes coimmunoprecipitation
T19824 44361-44364 Protein denotes Tat
T19825 44370-44375 Protein denotes IκB-α
T19826 44380-44383 Protein denotes p65
T19827 44391-44400 Positive_regulation denotes induction
T19828 44404-44410 Protein denotes MIP-1α
T19829 44411-44421 Gene_expression denotes expression
T19830 44422-44431 Positive_regulation denotes dependent
T19831 44422-44431 Positive_regulation denotes dependent
T19832 44435-44438 Protein denotes Tat
T19833 44443-44446 Protein denotes p65
T19834 44453-44456 Protein denotes Tat
T19835 44457-44466 Binding denotes occupancy
T19836 44474-44480 Protein denotes MIP-1α
T19837 44481-44495 Entity denotes NF-κB enhancer
T19838 44512-44521 Positive_regulation denotes increased
T19839 44522-44533 Binding denotes recruitment
T19840 44537-44540 Protein denotes p65
T19841 44593-44596 Protein denotes Tat
T19842 44614-44625 Binding denotes interaction
T19843 44631-44634 Protein denotes p65
T19844 44639-44644 Protein denotes IκB-α
T19845 44781-44785 Protein denotes IL-6
T19846 44795-44800 Protein denotes TNF-α
T19847 44811-44817 Protein denotes MIP-1α
T19848 44848-44853 Protein denotes TNF-α
T19849 44858-44862 Protein denotes IL-6
T19850 44864-44867 Protein denotes Tat
T19851 44868-44877 Positive_regulation denotes activated
T19852 44868-44877 Positive_regulation denotes activated
T19853 44868-44877 Positive_regulation denotes activated
T19854 44868-44877 Positive_regulation denotes activated
T19855 44868-44877 Positive_regulation denotes activated
T19856 44868-44877 Positive_regulation denotes activated
T19857 44891-44901 Gene_expression denotes expression
T19858 44891-44901 Gene_expression denotes expression
T19859 44905-44912 Binding denotes binding
T19860 44973-44982 Positive_regulation denotes promoting true
T19861 44973-44982 Positive_regulation denotes promoting true
T19862 44987-45013 Transcription denotes transcriptional elongation
T19863 44987-45013 Transcription denotes transcriptional elongation
T19864 45055-45058 Protein denotes Tat
T19865 45147-45155 Binding denotes assembly
T19866 45159-45162 Protein denotes Tat
T19867 45168-45171 Protein denotes p65
T19868 45212-45224 Binding denotes displacement true
T19869 45228-45233 Protein denotes IκB-α
T19870 45299-45302 Protein denotes Tat
T19871 45412-45415 Protein denotes Tat
T19872 46088-46091 Protein denotes Tat
T19873 46123-46134 Binding denotes interaction
T19874 46123-46134 Binding denotes interaction
T19875 46140-46145 Protein denotes IκB-α
T19876 46150-46153 Protein denotes p65
T19877 46175-46185 Negative_regulation denotes inhibitors
T19878 46189-46199 Negative_regulation denotes counteract
T19879 46204-46207 Protein denotes Tat
T25194 24666-24673 Binding denotes binding
T25195 24861-24864 Protein denotes p50
T25196 24867-24870 Protein denotes p65
T25197 24940-24945 Protein denotes β-Gal
T25198 24979-24982 Protein denotes p65
T25199 24999-25007 Protein denotes HA-IκB-α
T25200 25026-25029 Protein denotes Tat
T25201 25041-25044 Protein denotes Tat
T25202 25078-25088 Protein denotes luciferase
T25203 25169-25184 Protein denotes β-galactosidase
T26497 28810-28818 Protein denotes FLAG-Tat
T26498 28822-28843 Protein denotes FLAG-Tat C(22,25,27)A
T27249 31960-31966 Protein denotes NFKBIA
T27250 31972-31976 Protein denotes TLR2
T27251 31982-31987 Protein denotes GAPDH
T27252 31993-31997 Protein denotes ACTB
T27253 32064-32067 Protein denotes Tat
T27254 32302-32305 Protein denotes Tat
T27255 32340-32349 Protein denotes siRNA p65
T27256 32584-32587 Protein denotes Tat
T27257 32618-32629 Protein denotes siRNA IκB-α
T29102 44029-44043 Entity denotes NF-κB enhancer
T6041 8964-8967 Protein denotes Tat
T6042 9001-9004 Protein denotes Env
T6043 9232-9235 Protein denotes Env
T6044 9267-9270 Protein denotes p24
T27223 31394-31397 Protein denotes Tat
T27224 31412-31415 Protein denotes p65
T27225 31466-31475 Binding denotes occupying
T27226 31500-31509 Positive_regulation denotes promoting
T27227 31500-31509 Positive_regulation denotes promoting
T27228 31514-31517 Protein denotes p65
T27229 31518-31529 Binding denotes recruitment
T27230 31535-31540 Protein denotes IκB-α
T27231 31541-31553 Binding denotes displacement true
T27232 31606-31609 Protein denotes Tat
T27233 31619-31634 Protein denotes Tat C(22,25,27)
T27234 31644-31656 Protein denotes Tat R(49–57)
T27235 31686-31689 Protein denotes p65
T27236 31694-31706 Negative_regulation denotes interference
T27237 31754-31757 Protein denotes Tat
T27238 31770-31779 Protein denotes siRNA p65
T27239 31915-31925 Gene_expression denotes expression true
T27240 31915-31925 Gene_expression denotes expression true
T27241 31915-31925 Gene_expression denotes expression true
T27242 31915-31925 Gene_expression denotes expression true
T27243 31915-31925 Gene_expression denotes expression true
T27244 31915-31925 Gene_expression denotes expression true
T27245 31915-31925 Gene_expression denotes expression true
T27246 31929-31935 Protein denotes MIP-1α
T27247 31941-31945 Protein denotes CSF3
T27248 31951-31954 Protein denotes LTA
T29083 43641-43647 Protein denotes MIP-1α
T29084 43648-43663 Transcription denotes transcriptional
T29085 43664-43674 Positive_regulation denotes activation
T29086 43684-43687 Protein denotes Tat
T29087 43696-43703 Negative_regulation denotes absence
T29088 43707-43710 Protein denotes Tat
T29089 43712-43717 Protein denotes IκB-α
T29090 43718-43726 Binding denotes occupies
T29091 43731-43745 Entity denotes NF-κB enhancer
T29092 43753-43759 Protein denotes MIP-1α
T29093 43780-43789 Binding denotes interacts true
T29094 43878-43881 Protein denotes Tat
T29095 43882-43891 Positive_regulation denotes activates
T29096 43896-43902 Protein denotes MIP-1α
T29097 43903-43913 Gene_expression denotes expression
T29098 43917-43925 Negative_regulation denotes removing
T29099 43930-43935 Protein denotes IκB-α
T29100 43978-43988 Positive_regulation denotes increasing
T29101 43993-44000 Binding denotes binding
T19663 39608-39611 Protein denotes Tat
T19664 39655-39658 Protein denotes Tat
T19665 39704-39707 Protein denotes p65
T19666 39752-39762 Binding denotes interacted
T19667 39772-39777 Protein denotes IκB-α
T19668 39834-39837 Protein denotes Tat
T19669 39870-39881 Binding denotes interaction true
T19670 39887-39892 Protein denotes IκB-α
T13242 26459-26462 Protein denotes Tat
T13243 26463-26472 Positive_regulation denotes increases
T13244 26477-26480 Protein denotes p65
T13245 26490-26497 Binding denotes binding
T13246 26513-26524 Binding denotes association
T13247 26530-26533 Protein denotes p65
T13248 26552-26555 Protein denotes Tat
T13249 26567-26577 Binding denotes interacted true
T13250 26583-26586 Protein denotes p65
T13268 27100-27115 Protein denotes Tat T,N(23,24)A
T13269 27117-27130 Protein denotes Tat K(50,51)A
T13270 27135-27148 Protein denotes Tat R(49–57)A
T13271 27162-27169 Binding denotes binding true
T13272 27173-27189 Protein denotes Tat C(22,25,27)A
T13273 27232-27235 Protein denotes Tat
T13274 27236-27246 Binding denotes associated
T13275 27252-27255 Protein denotes p65
T13276 27268-27288 Entity denotes cysteine-rich domain
T13277 27343-27350 Positive_regulation denotes mediate true
T13278 29109-29112 Protein denotes p65
T13279 29113-29119 Entity denotes domain
T13280 29120-29128 Positive_regulation denotes required true
T13281 29133-29140 Binding denotes binding
T13282 29144-29147 Protein denotes Tat
T23896 16062-16065 Protein denotes Tat
T23897 16194-16203 Protein denotes siRNA Tat
T23898 16342-16345 Protein denotes p24
T23899 16388-16391 Protein denotes Tat
T23900 16392-16402 Gene_expression denotes expression true
T23901 16457-16467 Protein denotes luciferase
T23902 16565-16568 Protein denotes p65
T23903 16573-16576 Protein denotes p50
T23904 16577-16584 Binding denotes binding true
T1243 1543-1547 Protein denotes RelA
T1244 1548-1551 Protein denotes p65
T1245 1553-1558 Protein denotes c-Rel
T1246 1560-1564 Protein denotes RelB
T1247 1566-1569 Protein denotes p50
T1248 1574-1577 Protein denotes p52
T1249 1623-1642 Entity denotes Rel homology domain
T23905 16577-16584 Binding denotes binding true
T23906 16701-16711 Gene_expression denotes expression true
T23907 16701-16711 Gene_expression denotes expression true
T23908 16715-16718 Protein denotes p65
T23909 16723-16728 Protein denotes IκB-α
T23910 16877-16890 Protein denotes Hexokinase II
T1344 2634-2641 Binding denotes binding
T1345 2646-2653 Negative_regulation denotes impairs
T1346 2646-2653 Negative_regulation denotes impairs
T1347 2658-2669 Binding denotes association
T1348 2675-2680 Protein denotes IκB-α
T1349 2686-2697 Acetylation denotes acetylation
T1350 2701-2707 Entity denotes Lys310
T1351 2721-2724 Protein denotes p65
T1352 2903-2908 Protein denotes IκB-α
T1353 2939-2942 Protein denotes A20
T1354 2952-2965 Deacetylation denotes Deacetylation
T1355 2952-2965 Deacetylation denotes Deacetylation
T1356 2969-2972 Protein denotes p65
T1357 2976-2997 Protein denotes histone deacetylase-3
T1358 3001-3006 Protein denotes SIRT1
T6282 10612-10619 Binding denotes Binding true
T6283 10612-10619 Binding denotes Binding true
T6284 10612-10619 Binding denotes Binding true
T6285 10623-10626 Protein denotes p65
T6286 10628-10631 Protein denotes p50
T6287 10636-10644 Protein denotes FLAG-Tat
T8412 14991-14994 Protein denotes Tat
T8413 15026-15035 Binding denotes hijacking
T8414 15036-15041 Protein denotes IκB-α
T8415 15174-15184 Regulation denotes modulating
T8416 15189-15199 Gene_expression denotes expression
T8417 15203-15206 Protein denotes Tat
T8418 15265-15274 Protein denotes siRNA Tat
T8419 15359-15362 Protein denotes Env
T8420 15538-15548 Gene_expression denotes expression
T8421 15552-15555 Protein denotes Tat
T8460 18186-18194 Positive_regulation denotes observed
T8461 18492-18497 Protein denotes IκB-α
T8462 18498-18509 Protein_catabolism denotes degradation
T8463 18543-18546 Protein denotes Tat
T8464 18588-18591 Protein denotes Tat
T8465 18640-18649 Gene_expression denotes synthesis
T8466 18653-18658 Protein denotes IκB-α
T8467 18697-18700 Protein denotes Tat
T8468 18805-18808 Protein denotes Tat
T8469 18971-18974 Protein denotes p65
T8470 18979-18986 Binding denotes binding
T8471 19011-19014 Protein denotes p65
T8472 19050-19058 Positive_regulation denotes enhanced
T8473 19050-19058 Positive_regulation denotes enhanced
T8474 19062-19065 Protein denotes Tat
T8475 19077-19082 Protein denotes IκB-α
T8476 19113-19121 Regulation denotes affected true
T8477 19175-19184 Positive_regulation denotes increased
T8478 19228-19231 Protein denotes p65
T8479 19263-19276 Regulation denotes independently true
T8480 19296-19299 Protein denotes Tat
T8481 19338-19341 Protein denotes p65
T8482 19346-19353 Binding denotes binding
T8483 19366-19369 Protein denotes p65
T8484 19380-19388 Positive_regulation denotes elevated
T7506 13252-13261 Protein denotes protein G
T7507 13594-13603 Protein denotes protein G
T7508 14484-14490 Protein denotes MIP-1α
T7509 14492-14497 Protein denotes GAPDH
T7510 14502-14506 Protein denotes ACTB
T7511 14558-14562 Protein denotes CSF3
T7512 14564-14567 Protein denotes LTA
T7513 14569-14575 Protein denotes NFKBIA
T7514 14580-14584 Protein denotes TLR2
T6876 11214-11217 Protein denotes GST
T6877 11249-11252 Protein denotes GST
T6878 11282-11285 Protein denotes GST
T26470 27379-27382 Protein denotes Tat
T26471 27383-27393 Binding denotes associates
T26472 27399-27402 Protein denotes p65
T26473 27403-27413 Positive_regulation denotes increasing
T26474 27431-27438 Binding denotes binding
T26475 27485-27493 Protein denotes 3xHA-p65
T26476 27535-27538 Protein denotes Tat
T26477 27548-27563 Protein denotes Tat T,N(23,24)A
T26478 27573-27586 Protein denotes Tat K(50,51)A
T26479 27596-27609 Protein denotes Tat R(49–57)A
T26480 27622-27638 Protein denotes Tat C(22,25,27)A
T26481 27647-27655 Protein denotes FLAG-Tat
T26482 27856-27859 Protein denotes p65
T26483 27886-27893 Protein denotes GST-Tat
T26484 27895-27914 Protein denotes GST-Tat T,N(23,24)A
T26485 27916-27933 Protein denotes GST-Tat K(50,51)A
T26486 27935-27952 Protein denotes GST-Tat R(49–57)A
T26487 27954-27974 Protein denotes GST-Tat C(22,25,27)A
T26488 27979-27982 Protein denotes GST
T26489 28065-28068 Protein denotes GST
T26490 28231-28234 Protein denotes p65
T26491 28290-28293 Protein denotes Tat
T26492 28339-28347 Protein denotes 3xHA-p65
T26493 28357-28367 Protein denotes 3xHA-p65ΔC
T26494 28388-28398 Protein denotes 3xHA-p65ΔN
T26495 28438-28444 Protein denotes HA-p65
T26496 28635-28638 Protein denotes p65
T4892 6598-6608 Protein denotes luciferase
T4893 6621-6624 Protein denotes p50
T4894 6627-6630 Protein denotes p65
T4895 7015-7018 Protein denotes p50
T4896 7021-7024 Protein denotes p65
T4897 7428-7451 Protein denotes tumor necrosis factor-α
T4898 7453-7458 Protein denotes TNF-α
T4899 7572-7582 Protein denotes luciferase
T4900 7595-7600 Protein denotes β-Gal
T4901 7755-7765 Protein denotes Luciferase
T4902 7808-7818 Protein denotes luciferase
T4903 7823-7838 Protein denotes β-galactosidase
T4904 7993-8003 Protein denotes luciferase
T4905 8016-8031 Protein denotes β-galactosidase
T5669 8544-8559 Protein denotes siRNA Tat sense
T5670 8587-8606 Protein denotes siRNA Tat antisense
T5671 8731-8743 Negative_regulation denotes interference
T5672 8731-8743 Negative_regulation denotes interference
T5673 8747-8750 Protein denotes p65
T5674 8755-8760 Protein denotes IκB-α
T5675 8791-8800 Protein denotes siRNA p65
T5676 8805-8810 Protein denotes IκB-α
T24339 20207-20210 Protein denotes Tat
T24340 20268-20279 Binding denotes associating
T24341 20285-20290 Protein denotes IκB-α
T24342 20382-20385 Protein denotes Tat
T24343 20669-20672 Protein denotes p65
T24344 20674-20677 Protein denotes p50
T24345 20682-20690 Protein denotes FLAG-Tat
T24346 20691-20698 Binding denotes binding true
T24347 20691-20698 Binding denotes binding true
T24348 20691-20698 Binding denotes binding true
T24349 21294-21297 Protein denotes Tat
T24350 21498-21507 Protein denotes protein G
T11526 22862-22867 Protein denotes IκB-α
T11527 22868-22888 Binding denotes coimmunoprecipitated true
T11528 22868-22888 Binding denotes coimmunoprecipitated true
T11529 22898-22901 Protein denotes Tat
T11530 22919-22932 Protein denotes Tat R(49–57)A
T11531 22979-22999 Entity denotes arginine-rich domain
T11532 23003-23006 Protein denotes Tat
T7007 12253-12259 Transcription denotes levels
T7008 12356-12361 Protein denotes GAPDH
T4392 5876-5886 Protein denotes 3xHA-IκB-α
T4393 5900-5903 Protein denotes Tat
T4394 5917-5933 Protein denotes Tat C(22,25,27)A
T4395 5947-5972 Protein denotes Tat R(49,52,53,55,56,57)A
T4396 5982-5985 Protein denotes Tat
T4397 5995-6011 Protein denotes Tat C(22,25,27)A
T4398 6024-6049 Protein denotes Tat R(49,52,53,55,56,57)A
T4399 6121-6124 Protein denotes env
T4400 6241-6246 Protein denotes β-Gal
T4401 6316-6324 Protein denotes 3xHA-p65
T4402 6334-6344 Protein denotes 3xHA-p65ΔC
T4403 6361-6371 Protein denotes 3xHA-p65ΔN
T4404 6394-6409 Protein denotes Tat T,N(23,24)A
T4405 6423-6436 Protein denotes Tat K(50,51)A
T4406 6446-6461 Protein denotes Tat T,N(23,24)A
T4407 6471-6484 Protein denotes Tat K(50,51)A
T4408 6501-6504 Protein denotes Tat
T6706 10954-10962 Protein denotes HA-IκB-α
T6707 10964-10967 Protein denotes p65
T6708 10972-10975 Protein denotes Tat
T6709 10981-10990 Gene_expression denotes expressed
T6710 10981-10990 Gene_expression denotes expressed
T6711 10981-10990 Gene_expression denotes expressed
T6712 10991-10996 Positive_regulation denotes under
T6713 10991-10996 Positive_regulation denotes under
T6714 10991-10996 Positive_regulation denotes under
T17703 35128-35131 Protein denotes Tat
T17704 35164-35172 Positive_regulation denotes promotes
T17705 35177-35192 Transcription denotes transcriptional
T17706 35193-35203 Positive_regulation denotes activation
T17707 35207-35213 Protein denotes MIP-1α
T28262 35900-35903 Protein denotes Tat
T28263 35936-35944 Positive_regulation denotes enhances
T28264 35949-35955 Protein denotes MIP-1α
T28265 35956-35966 Gene_expression denotes expression
T28266 35971-35982 Binding denotes interaction
T28267 35988-35993 Protein denotes IκB-α
T28268 35998-36001 Protein denotes p65
T28269 36046-36055 Protein denotes siRNA Tat
T28270 36163-36171 Protein denotes FLAG-Tat
T28271 36196-36199 Protein denotes p24
T28272 36282-36285 Protein denotes Tat
T28273 36286-36296 Gene_expression denotes expression true
T28274 36327-36330 Protein denotes p24
T28275 36363-36370 Binding denotes binding true
T28276 36374-36377 Protein denotes p65
T28277 36535-36540 Protein denotes IκB-α
T28278 36943-36951 Protein denotes FLAG-Tat
T28279 37069-37078 Protein denotes protein G
T28280 37296-37305 Protein denotes siRNA Tat
T28281 37307-37316 Protein denotes siRNA p65
T28282 37425-37433 Protein denotes FLAG-Tat
T28283 37528-37534 Protein denotes MIP-1α
T28284 37535-37545 Gene_expression denotes expression true
T28285 37617-37626 Protein denotes siRNA Tat
T28286 37737-37745 Protein denotes FLAG-Tat
T28287 37922-37928 Protein denotes MIP-1α
T28288 37933-37938 Protein denotes GAPDH
T15143 33352-33362 Regulation denotes regulation
T15144 33366-33372 Protein denotes MIP-1α
T25168 23400-23403 Protein denotes Tat
T25169 23404-23412 Negative_regulation denotes relieves
T25170 23413-23416 Protein denotes p65
T25171 23426-23431 Protein denotes IκB-α
T25172 23432-23442 Negative_regulation denotes inhibition
T25173 23497-23500 Protein denotes Tat
T25174 23515-23523 Protein denotes HA-IκB-α
T25175 23571-23579 Protein denotes FLAG-Tat
T25176 23581-23601 Protein denotes FLAG-Tat T,N(23,24)A
T25177 23603-23621 Protein denotes FLAG-Tat K(50,51)A
T25178 23623-23641 Protein denotes FLAG-Tat R(49–57)A
T25179 23645-23666 Protein denotes FLAG-Tat C(22,25,27)A
T25180 23732-23735 Protein denotes Tat
T25181 23940-23943 Protein denotes p65
T25182 23990-23998 Protein denotes HA-IκB-α
T25183 24032-24040 Protein denotes FLAG-Tat
T25184 24044-24062 Protein denotes FLAG-Tat R(49–57)A
T25185 24081-24089 Protein denotes HA-IκB-α
T25186 24283-24286 Protein denotes p65
T25187 24394-24397 Protein denotes p65
T25188 24402-24409 Binding denotes binding true
T25189 24545-24548 Protein denotes p65
T25190 24584-24592 Protein denotes HA-IκB-α
T25191 24601-24609 Protein denotes FLAG-Tat
T25192 24613-24631 Protein denotes FLAG-Tat R(49–57)A
T25193 24647-24658 Negative_regulation denotes competition true
T129 1143-1147 Protein denotes TLR2
T130 1235-1238 Protein denotes Tat
T131 1244-1249 Protein denotes IκB-α
T132 1254-1257 Protein denotes p65
T133 91-94 Protein denotes p65
T134 439-442 Protein denotes Tat
R72 T141 T99 themeOf MIP-1α,responsive
R73 T141 T102 themeOf MIP-1α,expression
R681 T130 T109 themeOf Tat,interaction
R682 T131 T109 themeOf IκB-α,interaction
R683 T134 T108 themeOf Tat,hijacking
R684 T134 T110 causeOf Tat,preventing
R1062 T1243 T1302 themeOf RelA,dimerization
R1065 T1245 T1301 themeOf c-Rel,dimerization
R1083 T1249 T1265 causeOf Rel homology domain,for
R1084 T1249 T1264 causeOf Rel homology domain,for
R1085 T1249 T1263 causeOf Rel homology domain,for
R1086 T1249 T1262 causeOf Rel homology domain,for
R1087 T1249 T1257 causeOf Rel homology domain,for
R1088 T1249 T1243 partOf Rel homology domain,RelA
R1089 T1249 T1256 causeOf Rel homology domain,for
R1090 T1249 T1245 partOf Rel homology domain,c-Rel
R1091 T1249 T1255 causeOf Rel homology domain,for
R1092 T1249 T1246 partOf Rel homology domain,RelB
R1093 T1249 T1253 causeOf Rel homology domain,for
R1094 T1249 T1247 partOf Rel homology domain,p50
R1095 T1249 T1252 causeOf Rel homology domain,for
R1096 T1249 T1248 partOf Rel homology domain,p52
R1097 T1249 T1251 causeOf Rel homology domain,for
R1098 T1249 T1271 causeOf Rel homology domain,for
R1110 T1249 T1284 causeOf Rel homology domain,for
R1111 T1249 T1298 causeOf Rel homology domain,for
R1112 T1249 T1297 causeOf Rel homology domain,for
R1113 T1249 T1295 causeOf Rel homology domain,for
R1114 T1249 T1294 causeOf Rel homology domain,for
R1115 T1249 T1293 causeOf Rel homology domain,for
R1116 T1249 T1292 causeOf Rel homology domain,for
R1117 T1249 T1291 causeOf Rel homology domain,for
R1118 T1249 T1289 causeOf Rel homology domain,for
R1119 T1249 T1288 causeOf Rel homology domain,for
R1120 T1249 T1287 causeOf Rel homology domain,for
R1121 T1249 T1286 causeOf Rel homology domain,for
R1122 T1249 T1285 causeOf Rel homology domain,for
R1123 T1249 T1283 causeOf Rel homology domain,for
R1124 T1249 T1282 causeOf Rel homology domain,for
R1125 T1249 T1281 causeOf Rel homology domain,for
R1126 T1249 T1280 causeOf Rel homology domain,for
R1127 T1249 T1279 causeOf Rel homology domain,for
R1128 T1300 T1297 themeOf dimerization,for
R1129 T1300 T1295 themeOf dimerization,for
R1130 T1300 T1294 themeOf dimerization,for
R1131 T1300 T1293 themeOf dimerization,for
R1132 T1300 T1292 themeOf dimerization,for
R1133 T1301 T1251 themeOf dimerization,for
R1134 T1301 T1271 themeOf dimerization,for
R1135 T1301 T1290 themeOf dimerization,for
R1136 T1301 T1299 themeOf dimerization,for
R1137 T1301 T1254 themeOf dimerization,for
R1138 T1302 T1257 themeOf dimerization,for
R1139 T1302 T1256 themeOf dimerization,for
R1140 T1302 T1255 themeOf dimerization,for
R1141 T1302 T1253 themeOf dimerization,for
R1142 T1302 T1252 themeOf dimerization,for
R1143 T1303 T1272 themeOf dimerization,for
R1144 T1303 T1278 themeOf dimerization,for
R1145 T1303 T1296 themeOf dimerization,for
R1146 T1303 T1284 themeOf dimerization,for
R1147 T1303 T1298 themeOf dimerization,for
R1148 T1304 T1258 themeOf dimerization,for
R1149 T1304 T1259 themeOf dimerization,for
R1150 T1304 T1260 themeOf dimerization,for
R1151 T1304 T1261 themeOf dimerization,for
R1152 T1304 T1266 themeOf dimerization,for
R1153 T1305 T1285 themeOf binding,for
R1154 T1305 T1283 themeOf binding,for
R1155 T1305 T1282 themeOf binding,for
R1156 T1305 T1281 themeOf binding,for
R1157 T1305 T1280 themeOf binding,for
R1158 T1306 T1277 themeOf binding,for
R1159 T1306 T1276 themeOf binding,for
R1160 T1306 T1275 themeOf binding,for
R1161 T1306 T1274 themeOf binding,for
R1162 T1306 T1279 themeOf binding,for
R1163 T1307 T1291 themeOf binding,for
R1164 T1307 T1289 themeOf binding,for
R1165 T1307 T1288 themeOf binding,for
R1166 T1307 T1287 themeOf binding,for
R1167 T1307 T1286 themeOf binding,for
R1168 T1308 T1273 themeOf binding,for
R1169 T1308 T1250 themeOf binding,for
R1170 T1308 T1270 themeOf binding,for
R1171 T1308 T1269 themeOf binding,for
R1172 T1308 T1268 themeOf binding,for
R1173 T1309 T1267 themeOf binding,for
R1174 T1309 T1265 themeOf binding,for
R1175 T1309 T1264 themeOf binding,for
R1176 T1309 T1263 themeOf binding,for
R1177 T1309 T1262 themeOf binding,for
R1178 T1313 T1322 themeOf IκB-α,degraded
R1179 T1316 T1315 themeOf Ser32,phosphorylated
R1180 T1316 T1313 partOf Ser32,IκB-α
R1181 T1317 T1314 themeOf Ser36,phosphorylated
R1182 T1317 T1313 partOf Ser36,IκB-α
R1183 T1320 T1318 themeOf Lys21,ubiquitylated
R1184 T1320 T1313 partOf Lys21,IκB-α
R1185 T1321 T1319 themeOf Lys22,ubiquitylated
R1186 T1321 T1313 partOf Lys22,IκB-α
R1187 T1322 T1323 themeOf degraded,by
R1188 T1324 T1329 themeOf phosphorylation,by
R1189 T1324 T1332 themeOf phosphorylation,by
R1190 T1324 T1335 themeOf phosphorylation,by
R1191 T1328 T1324 themeOf Ser276,phosphorylation
R1192 T1328 T1327 partOf Ser276,p65
R1193 T1330 T1329 causeOf MSK1,by
R1194 T1331 T1326 themeOf Ser311,phosphorylation
R1195 T1331 T1327 partOf Ser311,p65
R1196 T1333 T1332 causeOf PKCζ,by
R1197 T1334 T1325 themeOf Ser536,phosphorylation
R1198 T1334 T1327 partOf Ser536,p65
R1199 T1336 T1335 causeOf IKKα,by
R1200 T1337 T1343 causeOf Acetylation,increases
R1201 T1337 T1345 causeOf Acetylation,impairs
R1202 T1338 T1342 causeOf Acetylation,increases
R1203 T1338 T1346 causeOf Acetylation,impairs
R1204 T1339 T1344 themeOf p65,binding
R1205 T1339 T1347 themeOf p65,association
R1206 T1340 T1337 themeOf Lys218,Acetylation
R1207 T1340 T1339 partOf Lys218,p65
R1208 T1341 T1338 themeOf Lys221,Acetylation
R1209 T1341 T1339 partOf Lys221,p65
R1210 T1344 T1343 themeOf binding,increases
R1211 T1344 T1342 themeOf binding,increases
R1212 T1347 T1345 themeOf association,impairs
R1213 T1347 T1346 themeOf association,impairs
R1214 T1348 T1347 themeOf IκB-α,association
R1215 T1350 T1349 themeOf Lys310,acetylation
R1216 T1350 T1339 partOf Lys310,p65
R1217 T1356 T1355 themeOf p65,Deacetylation
R1218 T1356 T1354 themeOf p65,Deacetylation
R1219 T1357 T1355 causeOf histone deacetylase-3,Deacetylation
R1220 T1358 T1354 causeOf SIRT1,Deacetylation
R1221 T1362 T1359 themeOf Lys122,acetylation
R1222 T1362 T1361 partOf Lys122,p65
R1223 T1363 T1360 themeOf Lys123,acetylation
R1224 T1363 T1361 partOf Lys123,p65
R1225 T1364 T1367 causeOf binding,induces
R1226 T1365 T1364 themeOf gp120,binding
R1227 T1366 T1364 themeOf CD4,binding
R1228 T1368 T1367 themeOf activation,induces
R1229 T1369 T1368 themeOf procaspase 8,activation
R1230 T1370 T1371 themeOf Tat,interacts
R1231 T1372 T1373 themeOf Tat,binds
R1232 T1373 T1379 causeOf binds,activate
R1233 T1373 T1378 causeOf binds,activate
R1234 T1374 T1380 themeOf tumor necrosis factor β,transcription
R1235 T1375 T1374 equivalentTo TNFβ,tumor necrosis factor β
R1236 T1376 T1381 themeOf interleukin-6,transcription
R1237 T1377 T1376 equivalentTo IL-6,interleukin-6
R1238 T1380 T1379 themeOf transcription,activate
R1239 T1381 T1378 themeOf transcription,activate
R1240 T1382 T1384 themeOf Tat,interacting
R1241 T1382 T1386 themeOf Tat,interacting
R1242 T1382 T1385 themeOf Tat,interacting
R1243 T1382 T1383 themeOf Tat,interacting
R1244 T1382 T1387 themeOf Tat,interacting
R1245 T1382 T1388 themeOf Tat,interacting
R1246 T1382 T1389 themeOf Tat,interacting
R1247 T1382 T1391 themeOf Tat,interacting
R1248 T1382 T1390 themeOf Tat,interacting
R1249 T1392 T1384 themeOf Sp1,interacting
R1250 T1393 T1386 themeOf TFIID,interacting
R1251 T1394 T1385 themeOf E2F-4,interacting
R1252 T1395 T1383 themeOf C/EBPβ,interacting
R1253 T1396 T1387 themeOf cyclin T1,interacting
R1254 T1397 T1388 themeOf CDK9,interacting
R1255 T1398 T1389 themeOf p300,interacting
R1256 T1399 T1391 themeOf CBP,interacting
R1257 T1400 T1390 themeOf P/CAF,interacting
R1258 T1402 T1401 themeOf Tat,released
R1259 T1402 T1403 themeOf Tat,binding
R1260 T1406 T1405 themeOf Tat,expressed
R1261 T1407 T1408 causeOf Tat,induced
R1262 T1407 T1412 causeOf Tat,inhibiting
R1263 T1409 T1408 themeOf degradation,induced
R1264 T1410 T1409 themeOf IκB-α,degradation
R1265 T1413 T1414 causeOf SIRT-1,mediated
R1266 T1414 T1412 themeOf mediated,inhibiting
R1267 T1415 T1414 themeOf deacetylation,mediated
R1268 T1417 T1415 themeOf Lys310,deacetylation
R1269 T1417 T1416 partOf Lys310,p65
R1270 T1421 T1420 themeOf IκB-α,synthesis
R1271 T1422 T1423 themeOf IκB-α,binds
R1272 T1424 T1423 themeOf Tat,binds
R1273 T1425 T1426 themeOf Tat,interaction
R1274 T1427 T1426 themeOf IκB-α,interaction
R5357 T6287 T6282 themeOf FLAG-Tat,Binding
R6981 T8444 T8442 causeOf Tat,elevated
R6997 T8474 T8473 causeOf Tat,enhanced
R6998 T8474 T8476 causeOf Tat,affected
R6999 T8475 T8476 themeOf IκB-α,affected
R7000 T8477 T8479 themeOf increased,independently
R7001 T8478 T8477 themeOf p65,increased
R7002 T8480 T8479 causeOf Tat,independently
R7003 T8481 T8482 themeOf p65,binding
R7004 T8482 T8484 themeOf binding,elevated
R7005 T8482 T8487 themeOf binding,dropped
R7006 T8483 T8485 themeOf p65,elevated
R7007 T8483 T8488 themeOf p65,dropped
R7008 T8486 T8484 causeOf Tat,elevated
R7009 T8486 T8485 causeOf Tat,elevated
R7010 T8489 T8490 themeOf Tat,negative
R7011 T8490 T8487 causeOf negative,dropped
R7012 T8490 T8488 causeOf negative,dropped
R7013 T8491 T8492 themeOf Tat,bound
R7014 T8491 T8493 themeOf Tat,binding
R7015 T8493 T8494 themeOf binding,increased
R7016 T8495 T8497 themeOf Degradation,induced
R7017 T8496 T8495 themeOf IκB-α,Degradation
R7018 T8496 T8499 themeOf IκB-α,synthesis
R7019 T8497 T8498 causeOf induced,followed
R7020 T8499 T8498 themeOf synthesis,followed
R7021 T8502 T8503 causeOf Tat,affecting
R7022 T8504 T8503 themeOf IκB-α,affecting
R7023 T8505 T8506 themeOf Tat,binds
R7024 T8507 T8506 themeOf sixth ankyrin,binds
R7025 T8507 T8508 partOf sixth ankyrin,IκB-α
R7026 T8509 T8510 causeOf Tat,counteracted
R7027 T8511 T8510 themeOf generation,counteracted
R7028 T8512 T8511 themeOf IκB-α,generation
R7029 T8514 T8513 themeOf IκB-α,association
R7030 T8515 T8513 themeOf p65,association
R7031 T8517 T8516 themeOf IκB-α,synthesis
R7032 T8518 T8522 themeOf Coimmunoprecipitation,halved
R7033 T8519 T8518 themeOf IκB-α,Coimmunoprecipitation
R7034 T8520 T8518 themeOf p65,Coimmunoprecipitation
R7035 T8523 T8522 causeOf Tat,halved
R7036 T8524 T8525 themeOf Tat,coimmunoprecipitated
R7037 T8526 T8525 themeOf IκB-α,coimmunoprecipitated
R7038 T8527 T8528 causeOf Tat,competed
R7039 T8529 T8530 themeOf IκB-α,binding
R7040 T8530 T8528 themeOf binding,competed
R7041 T8531 T8530 themeOf p65,binding
R9393 T11513 T11517 themeOf IκB-α,binding
R9399 T11519 T11518 themeOf Tat,interaction
R9400 T11520 T11518 themeOf IκB-α,interaction
R9401 T11526 T11528 themeOf IκB-α,coimmunoprecipitated
R9402 T11526 T11527 themeOf IκB-α,coimmunoprecipitated
R9403 T11529 T11528 themeOf Tat,coimmunoprecipitated
R9404 T11530 T11527 themeOf Tat R(49–57)A,coimmunoprecipitated
R9405 T11531 T11533 causeOf arginine-rich domain,involved
R9406 T11531 T11532 partOf arginine-rich domain,Tat
R9407 T11532 T11534 themeOf Tat,binding
R9408 T11534 T11533 themeOf binding,involved
R9409 T11535 T11534 themeOf IκB-α,binding
R9410 T11536 T11537 themeOf Tat,associating
R9411 T11537 T11539 causeOf associating,competed
R9412 T11538 T11537 themeOf IκB-α,associating
R9413 T11540 T11539 themeOf binding,competed
R9414 T11541 T11540 themeOf IκB-α,binding
R9415 T11542 T11540 themeOf p65,binding
R9418 T11546 T11544 themeOf site,lacked
R9419 T11546 T11536 partOf site,Tat
R9445 T11588 T11586 causeOf Tat,restored
R9446 T11589 T11587 causeOf Tat R(49–57)A,restored
R9447 T11590 T11597 themeOf Tat,associating
R9448 T11590 T11599 causeOf Tat,competing
R9449 T11593 T11594 causeOf IκB-α,repression
R9450 T11594 T11591 themeOf repression,counteracts
R9451 T11594 T11592 themeOf repression,counteracts
R9452 T11595 T11596 themeOf p65,binding
R9453 T11596 T11594 themeOf binding,repression
R9454 T11597 T11591 causeOf associating,counteracts
R9455 T11598 T11597 themeOf IκB-α,associating
R9456 T11598 T11600 themeOf IκB-α,binding
R9457 T11599 T11592 causeOf competing,counteracts
R9458 T11600 T11599 themeOf binding,competing
R9459 T11601 T11600 themeOf p65,binding
R10718 T13255 T13256 themeOf p65,coimmunoprecipitated
R10719 T13255 T13262 themeOf p65,coimmunoprecipitation
R10720 T13257 T13256 themeOf Tat,coimmunoprecipitated
R10721 T13262 T13261 themeOf coimmunoprecipitation,decrease
R10722 T13263 T13261 causeOf "Tat C(22,25,27)A",decrease
R10723 T13263 T13262 themeOf "Tat C(22,25,27)A",coimmunoprecipitation
R10724 T13266 T13265 themeOf p65,binding
R10725 T13266 T13271 themeOf p65,binding
R10726 T13267 T13265 themeOf Tat,binding
R10727 T13272 T13271 themeOf "Tat C(22,25,27)A",binding
R10728 T13274 T13277 themeOf associated,mediate
R10729 T13275 T13274 themeOf p65,associated
R10730 T13276 T13274 themeOf cysteine-rich domain,associated
R10731 T13276 T13273 partOf cysteine-rich domain,Tat
R10732 T13278 T13281 themeOf p65,binding
R10733 T13279 T13280 causeOf domain,required
R10734 T13279 T13278 partOf domain,p65
R10735 T13281 T13280 themeOf binding,required
R10736 T13282 T13281 themeOf Tat,binding
R10737 T13287 T13286 themeOf transactivation domain,deleted
R10738 T13287 T13278 partOf transactivation domain,p65
R10739 T13289 T13285 themeOf RHD,deleted
R10740 T13289 T13278 partOf RHD,p65
R10741 T13291 T13292 themeOf Tat,coimmunoprecipitated
R10742 T13293 T13292 themeOf p65ΔC (1–318),coimmunoprecipitated
R10743 T13295 T13297 themeOf RHD,interaction
R10744 T13295 T13296 partOf RHD,p65
R10745 T13298 T13297 themeOf Tat,interaction
R10746 T13300 T13299 causeOf Tat,effect
R10747 T13301 T13302 themeOf p65,binding
R10748 T13302 T13299 themeOf binding,effect
R10749 T13306 T13307 themeOf p65,binding
R10750 T13308 T13309 causeOf Tat,increased
R10751 T13310 T13309 themeOf binding,increased
R10752 T13310 T13317 themeOf binding,ineffective
R10753 T13311 T13310 themeOf p65,binding
R10754 T13312 T13317 causeOf "Tat C(22,25,27)A",ineffective
R10755 T13315 T13313 themeOf site,lacking
R10756 T13315 T13308 partOf site,Tat
R10757 T13315 T13314 themeOf site,binding
R10758 T13316 T13314 themeOf p65,binding
R10759 T13318 T13319 themeOf p65,binding
R10760 T13320 T13321 causeOf Tat,enhanced
R10761 T13322 T13323 themeOf p65,binding
R10762 T13323 T13321 themeOf binding,enhanced
R12067 T15079 T15083 causeOf Tat,promotes
R12068 T15079 T15082 causeOf Tat,promotes
R12070 T15084 T15085 themeOf p65,recruitment
R12071 T15084 T15087 themeOf p65,displacement
R12072 T15085 T15083 themeOf recruitment,promotes
R12073 T15086 T15087 themeOf IκB-α,displacement
R12074 T15087 T15082 themeOf displacement,promotes
R12075 T15092 T15097 causeOf Tat,increased
R12076 T15092 T15095 causeOf Tat,increased
R12077 T15092 T15094 causeOf Tat,increased
R12078 T15092 T15093 causeOf Tat,increased
R12079 T15092 T15096 causeOf Tat,increased
R12080 T15098 T15095 themeOf expression,increased
R12081 T15098 T15113 themeOf expression,ineffective
R12082 T15098 T15115 themeOf expression,ineffective
R12083 T15099 T15093 themeOf expression,increased
R12084 T15099 T15118 themeOf expression,ineffective
R12085 T15099 T15112 themeOf expression,ineffective
R12086 T15100 T15096 themeOf expression,increased
R12087 T15100 T15114 themeOf expression,ineffective
R12088 T15100 T15111 themeOf expression,ineffective
R12089 T15101 T15094 themeOf expression,increased
R12090 T15101 T15116 themeOf expression,ineffective
R12091 T15101 T15117 themeOf expression,ineffective
R12092 T15102 T15097 themeOf expression,increased
R12093 T15102 T15110 themeOf expression,ineffective
R12094 T15102 T15119 themeOf expression,ineffective
R12095 T15103 T15102 themeOf MIP-1α,expression
R12096 T15104 T15098 themeOf CSF3,expression
R12097 T15105 T15101 themeOf LTA,expression
R12098 T15106 T15099 themeOf NFKBIA,expression
R12099 T15107 T15100 themeOf TLR2,expression
R12100 T15108 T15110 causeOf "Tat C(22,25,27)A",ineffective
R12101 T15108 T15113 causeOf "Tat C(22,25,27)A",ineffective
R12102 T15108 T15116 causeOf "Tat C(22,25,27)A",ineffective
R12103 T15108 T15118 causeOf "Tat C(22,25,27)A",ineffective
R12104 T15108 T15114 causeOf "Tat C(22,25,27)A",ineffective
R12105 T15109 T15119 causeOf Tat R(49–57)A,ineffective
R12106 T15109 T15115 causeOf Tat R(49–57)A,ineffective
R12107 T15109 T15117 causeOf Tat R(49–57)A,ineffective
R12108 T15109 T15112 causeOf Tat R(49–57)A,ineffective
R12109 T15109 T15111 causeOf Tat R(49–57)A,ineffective
R12110 T15128 T15129 themeOf Tat,interaction
R12111 T15130 T15129 themeOf p65,interaction
R12112 T15132 T15133 themeOf MIP-1α,activated
R12113 T15134 T15133 causeOf Tat,activated
R12114 T15135 T15136 themeOf MIP-1α,expression
R12115 T15136 T15137 themeOf expression,increased
R12116 T15138 T15139 themeOf MIP-1α,production
R12141 T15174 T15190 causeOf Tat,ineffective
R12142 T15174 T15189 causeOf Tat,ineffective
R12145 T15174 T15176 causeOf Tat,increased
R12146 T15174 T15177 causeOf Tat,increased
R12147 T15179 T15176 themeOf recruitment,increased
R12148 T15180 T15175 themeOf recruitment,increased
R12149 T15181 T15177 themeOf recruitment,increased
R12150 T15182 T15178 themeOf recruitment,increased
R12151 T15183 T15181 themeOf p65,recruitment
R12152 T15183 T15180 themeOf p65,recruitment
R12153 T15183 T15182 themeOf p65,recruitment
R12154 T15183 T15179 themeOf p65,recruitment
R12155 T15184 T15181 themeOf NF-κB enhancers,recruitment
R12156 T15184 T15188 partOf NF-κB enhancers,TLR2
R12157 T15184 T15180 themeOf NF-κB enhancers,recruitment
R12158 T15184 T15185 partOf NF-κB enhancers,CSF3
R12159 T15184 T15182 themeOf NF-κB enhancers,recruitment
R12160 T15184 T15186 partOf NF-κB enhancers,LTA
R12161 T15184 T15179 themeOf NF-κB enhancers,recruitment
R12162 T15184 T15187 partOf NF-κB enhancers,NFKBIA
R12163 T15191 T15190 themeOf promoters,ineffective
R12164 T15191 T15192 partOf promoters,GAPDH
R12165 T15191 T15189 themeOf promoters,ineffective
R12166 T15191 T15193 partOf promoters,ACTB
R12167 T15194 T15195 themeOf Tat,bound
R12168 T15195 T15199 themeOf bound,loss
R12169 T15198 T15195 themeOf promoters,bound
R12170 T15198 T15196 partOf promoters,GAPDH
R12171 T15200 T15201 themeOf p65,interference
R12172 T15201 T15199 causeOf interference,loss
R12173 T15202 T15203 themeOf Tat,occupancy
R12174 T15202 T15206 themeOf Tat,interaction
R12175 T15203 T15204 themeOf occupancy,via
R12176 T15205 T15206 themeOf p65,interaction
R12177 T15206 T15204 causeOf interaction,via
R12178 T15207 T15208 themeOf IκB-α,chromatin-immunoprecipitated
R12179 T15208 T15210 themeOf chromatin-immunoprecipitated,removed
R12180 T15208 T15211 themeOf chromatin-immunoprecipitated,removed
R12181 T15212 T15210 causeOf Tat,removed
R12182 T15213 T15214 themeOf IκB-α,interference
R12183 T15214 T15211 causeOf interference,removed
R12184 T15215 T15216 causeOf Tat,displaced
R12185 T15217 T15218 themeOf IκB-α,from
R12186 T15218 T15216 themeOf from,displaced
R14193 T17703 T17709 themeOf Tat,interacting
R14194 T17704 T17708 themeOf promotes,by
R14197 T17707 T17705 themeOf MIP-1α,transcriptional
R14198 T17709 T17708 causeOf interacting,by
R14205 T17723 T17727 themeOf expression,detected
R14206 T17724 T17728 themeOf expression,detected
R14207 T17725 T17724 themeOf Tat,expression
R14208 T17726 T17723 themeOf p24,expression
R14209 T17729 T17728 causeOf siRNA Tat,detected
R14210 T17729 T17727 causeOf siRNA Tat,detected
R14211 T17730 T17731 themeOf p65,binding
R14212 T17731 T17732 themeOf binding,induced
R14213 T17731 T17736 themeOf binding,increased
R14214 T17737 T17736 causeOf Tat,increased
R14215 T17738 T17740 causeOf Degradation,followed
R14216 T17739 T17738 themeOf IκB-α,Degradation
R14217 T17741 T17740 themeOf synthesis,followed
R14218 T17741 T17743 themeOf synthesis,independently
R14219 T17742 T17741 themeOf IκB-α,synthesis
R14220 T17744 T17743 causeOf Tat,independently
R14221 T17746 T17747 themeOf Tat,coimmunoprecipitated
R14222 T17746 T17750 causeOf Tat,activated
R14223 T17748 T17747 themeOf IκB-α,coimmunoprecipitated
R14224 T17750 T17754 causeOf activated,dependent
R14225 T17750 T17755 themeOf activated,lack
R14226 T17751 T17752 themeOf MIP-1α,expression
R14227 T17752 T17754 themeOf expression,dependent
R14228 T17753 T17750 themeOf p65,activated
R14229 T17755 T17756 themeOf lack,following
R14230 T17759 T17761 themeOf Tat,recruited
R14231 T17762 T17761 themeOf NF-κB enhancer,recruited
R14232 T17762 T17763 partOf NF-κB enhancer,MIP-1α
R14233 T17762 T17765 themeOf NF-κB enhancer,occupancy
R14234 T17764 T17765 themeOf p65,occupancy
R14235 T17765 T17766 themeOf occupancy,abolished
R14236 T17767 T17766 causeOf siRNA Tat,abolished
R14237 T17768 T17769 themeOf Tat,associated
R14238 T17768 T17777 themeOf Tat,occupancy
R14239 T17768 T17780 causeOf Tat,increased
R14240 T17770 T17769 themeOf IκB-α,associated
R14241 T17773 T17774 causeOf p65,activation
R14242 T17774 T17772 themeOf activation,induced
R14243 T17775 T17776 themeOf MIP-1α,expression
R14244 T17776 T17774 themeOf expression,activation
R14245 T17779 T17777 themeOf promoter,occupancy
R14246 T17779 T17778 partOf promoter,MIP-1α
R14247 T17779 T17781 themeOf promoter,recruitment
R14248 T17781 T17780 themeOf recruitment,increased
R14249 T17782 T17781 themeOf p65,recruitment
R15695 T19664 T19666 themeOf Tat,interacted
R15697 T19668 T19669 themeOf Tat,interaction
R15698 T19670 T19669 themeOf IκB-α,interaction
R15699 T19673 T19674 themeOf Tat,expression
R15700 T19674 T19672 themeOf expression,silence
R15701 T19675 T19676 themeOf IκB-α,degradation
R15702 T19678 T19677 themeOf Tat,absence
R15703 T19680 T19679 themeOf IκB-α,synthesis
R15704 T19683 T19682 themeOf Tat,silencing
R15705 T19684 T19685 causeOf Tat,affecting
R15706 T19686 T19685 themeOf IκB-α,affecting
R15707 T19690 T19689 themeOf IκB-α,synthesized
R15708 T19691 T19692 themeOf Tat,association
R15709 T19692 T19694 causeOf association,interfered
R15710 T19693 T19692 themeOf IκB-α,association
R15711 T19695 T19694 themeOf generation,interfered
R15712 T19696 T19695 themeOf IκB-α,generation
R15713 T19697 T19695 themeOf p65,generation
R15714 T19698 T19699 causeOf Tat,competed
R15715 T19698 T19703 causeOf Tat,prevented
R15716 T19700 T19699 themeOf binding,competed
R15717 T19701 T19700 themeOf IκB-α,binding
R15718 T19702 T19700 themeOf p65,binding
R15719 T19704 T19705 causeOf IκB-α,repression
R15720 T19705 T19703 themeOf repression,prevented
R15721 T19706 T19705 themeOf p65,repression
R15722 T19707 T19708 themeOf Tat,associated
R15723 T19707 T19710 causeOf Tat,increased
R15724 T19709 T19708 themeOf p65,associated
R15725 T19711 T19712 themeOf p65,binding
R15726 T19712 T19710 themeOf binding,increased
R15727 T19713 T19716 themeOf stronger,consequence
R15728 T19714 T19713 themeOf binding,stronger
R15729 T19715 T19714 themeOf p65,binding
R15730 T19715 T19717 themeOf p65,association
R15731 T19717 T19716 causeOf association,consequence
R15732 T19717 T19719 causeOf association,caused
R15733 T19718 T19717 themeOf Tat,association
R15734 T19720 T19719 themeOf change,caused
R15735 T19721 T19720 themeOf p65,change
R15736 T19722 T19725 themeOf Tat,binding
R15737 T19723 T19724 causeOf cysteine-rich sequence,involved
R15738 T19723 T19722 partOf cysteine-rich sequence,Tat
R15739 T19725 T19724 themeOf binding,involved
R15740 T19726 T19725 themeOf RHD,binding
R15741 T19726 T19727 partOf RHD,p65
R15742 T19728 T19732 themeOf Tat,binding
R15743 T19728 T19735 causeOf Tat,releasing
R15744 T19729 T19730 causeOf arginine-rich sequence,required
R15745 T19729 T19728 partOf arginine-rich sequence,Tat
R15746 T19729 T19731 causeOf arginine-rich sequence,required
R15747 T19732 T19730 themeOf binding,required
R15748 T19733 T19732 themeOf sixth ankyrin,binding
R15749 T19733 T19734 partOf sixth ankyrin,IκB-α
R15750 T19735 T19731 themeOf releasing,required
R15751 T19736 T19738 themeOf p65,inhibition
R15752 T19738 T19735 themeOf inhibition,releasing
R15753 T19739 T19740 themeOf Tat,hijacking
R15754 T19739 T19742 causeOf Tat,shielding
R15755 T19739 T19746 causeOf Tat,enforcing
R15756 T19741 T19740 themeOf IκB-α,hijacking
R15757 T19743 T19745 themeOf p65,embrace
R15758 T19744 T19745 themeOf IκB-α,embrace
R15759 T19745 T19742 themeOf embrace,shielding
R15760 T19747 T19748 themeOf p65,binding
R15761 T19748 T19746 themeOf binding,enforcing
R15762 T19757 T19758 causeOf Tat,increased
R15763 T19757 T19761 themeOf Tat,recovered
R15764 T19759 T19758 themeOf recruitment,increased
R15765 T19760 T19759 themeOf p65,recruitment
R15766 T19762 T19764 causeOf interference,abolished
R15767 T19763 T19762 themeOf p65,interference
R15768 T19765 T19766 themeOf Tat,occupancy
R15769 T19766 T19764 themeOf occupancy,abolished
R15770 T19767 T19768 themeOf Tat,binding
R15771 T19768 T19769 themeOf binding,mediated
R15772 T19770 T19769 causeOf p65,mediated
R15773 T19771 T19779 themeOf Tat,association
R15774 T19773 T19774 themeOf p65,binding
R15775 T19774 T19772 themeOf binding,displaced
R15776 T19775 T19774 themeOf IκB-α,binding
R15777 T19777 T19779 themeOf p65,association
R15778 T19777 T19778 themeOf p65,binding
R15779 T19778 T19776 themeOf binding,increased
R15780 T19779 T19772 causeOf association,displaced
R15781 T19779 T19776 causeOf association,increased
R15782 T19780 T19787 causeOf Tat,interfering
R15783 T19780 T19785 themeOf Tat,associating
R15785 T19783 T19782 themeOf recruitment,increased
R15786 T19784 T19783 themeOf p65,recruitment
R15787 T19785 T19782 causeOf associating,increased
R15791 T19789 T19788 themeOf p65,assembly
R15792 T19790 T19788 themeOf IκB-α,assembly
R15793 T19791 T19793 themeOf IκB-α,associated
R15794 T19793 T19792 themeOf associated,found
R15795 T19794 T19792 causeOf absence,found
R15796 T19795 T19794 themeOf Tat,absence
R15797 T19797 T19798 themeOf IκB-α,occupancy
R15798 T19799 T19800 themeOf IκB-α,associated
R15799 T19799 T19804 themeOf IκB-α,removed
R15800 T19803 T19801 themeOf promoter,at
R15801 T19803 T19802 partOf promoter,hes1
R15802 T19804 T19805 themeOf removed,following
R15803 T19804 T19807 causeOf removed,causing
R15804 T19806 T19805 causeOf TNF-α,following
R15805 T19808 T19809 themeOf hes1,transcriptional activation
R15806 T19809 T19807 themeOf transcriptional activation,causing
R15807 T19810 T19812 causeOf Tat,by
R15808 T19810 T19811 causeOf Tat,by
R15809 T19813 T19812 themeOf removing,by
R15810 T19814 T19813 themeOf IκB-α,removing
R15811 T19815 T19811 themeOf promoting,by
R15812 T19816 T19817 themeOf p65,loading
R15813 T19817 T19815 themeOf loading,promoting
R15814 T19818 T19819 themeOf Tat,cross talk
R15815 T19818 T19819 causeOf Tat,cross talk
R15816 T19824 T19823 themeOf Tat,coimmunoprecipitation
R15817 T19825 T19823 themeOf IκB-α,coimmunoprecipitation
R15818 T19827 T19830 themeOf induction,dependent
R15819 T19827 T19831 themeOf induction,dependent
R15820 T19828 T19829 themeOf MIP-1α,expression
R15821 T19829 T19827 themeOf expression,induction
R15822 T19832 T19830 causeOf Tat,dependent
R15823 T19833 T19831 causeOf p65,dependent
R15824 T19834 T19835 themeOf Tat,occupancy
R15825 T19837 T19835 themeOf NF-κB enhancer,occupancy
R15826 T19837 T19836 partOf NF-κB enhancer,MIP-1α
R15827 T19837 T19839 themeOf NF-κB enhancer,recruitment
R15828 T19839 T19838 themeOf recruitment,increased
R15829 T19840 T19839 themeOf p65,recruitment
R15830 T19841 T19842 themeOf Tat,interaction
R15831 T19843 T19842 themeOf p65,interaction
R15832 T19848 T19858 themeOf TNF-α,expression
R15833 T19848 T19862 themeOf TNF-α,transcriptional elongation
R15834 T19849 T19857 themeOf IL-6,expression
R15835 T19849 T19863 themeOf IL-6,transcriptional elongation
R15836 T19850 T19859 themeOf Tat,binding
R15837 T19857 T19854 themeOf expression,activated
R15838 T19857 T19851 themeOf expression,activated
R15839 T19857 T19855 themeOf expression,activated
R15840 T19858 T19856 themeOf expression,activated
R15841 T19858 T19852 themeOf expression,activated
R15842 T19858 T19853 themeOf expression,activated
R15843 T19859 T19856 causeOf binding,activated
R15844 T19859 T19861 causeOf binding,promoting
R15845 T19859 T19860 causeOf binding,promoting
R15846 T19859 T19854 causeOf binding,activated
R15847 T19860 T19853 causeOf promoting,activated
R15848 T19860 T19855 causeOf promoting,activated
R15849 T19861 T19852 causeOf promoting,activated
R15850 T19861 T19851 causeOf promoting,activated
R15851 T19862 T19861 themeOf transcriptional elongation,promoting
R15852 T19863 T19860 themeOf transcriptional elongation,promoting
R15853 T19866 T19865 themeOf Tat,assembly
R15854 T19867 T19865 themeOf p65,assembly
R15855 T19867 T19868 themeOf p65,displacement
R15856 T19869 T19868 themeOf IκB-α,displacement
R15857 T19872 T19873 themeOf Tat,interaction
R15858 T19872 T19874 themeOf Tat,interaction
R15859 T19875 T19873 themeOf IκB-α,interaction
R15860 T19876 T19874 themeOf p65,interaction
R15861 T19878 T19877 themeOf counteract,inhibitors
R15862 T19879 T19878 themeOf Tat,counteract
R22692 T29091 T29090 themeOf NF-κB enhancer,occupies
R22693 T29091 T29092 partOf NF-κB enhancer,MIP-1α
R22694 T29094 T29095 causeOf Tat,activates
R22695 T29094 T29098 causeOf Tat,removing
R22696 T29094 T29100 causeOf Tat,increasing
R22697 T29096 T29097 themeOf MIP-1α,expression
R22698 T29097 T29095 themeOf expression,activates
R22699 T29099 T29098 themeOf IκB-α,removing
R22700 T29101 T29100 themeOf binding,increasing
R22701 T29102 T29101 themeOf NF-κB enhancer,binding
R22702 T29102 T29096 partOf NF-κB enhancer,MIP-1α
R21342 T27223 T27225 themeOf Tat,occupying
R21343 T27223 T27227 causeOf Tat,promoting
R21344 T27223 T27226 causeOf Tat,promoting
R21345 T27228 T27229 themeOf p65,recruitment
R21346 T27228 T27231 themeOf p65,displacement
R21347 T27229 T27227 themeOf recruitment,promoting
R21348 T27230 T27231 themeOf IκB-α,displacement
R21349 T27231 T27226 themeOf displacement,promoting
R21350 T27235 T27236 themeOf p65,interference
R21351 T27246 T27241 themeOf MIP-1α,expression
R21352 T27247 T27240 themeOf CSF3,expression
R21353 T27248 T27239 themeOf LTA,expression
R21354 T27249 T27242 themeOf NFKBIA,expression
R21355 T27250 T27244 themeOf TLR2,expression
R21356 T27251 T27243 themeOf GAPDH,expression
R21357 T27252 T27245 themeOf ACTB,expression
R22686 T29083 T29084 themeOf MIP-1α,transcriptional
R22687 T29084 T29085 themeOf transcriptional,activation
R22688 T29086 T29085 causeOf Tat,activation
R22689 T29088 T29087 themeOf Tat,absence
R22690 T29089 T29090 themeOf IκB-α,occupies
R22691 T29089 T29093 themeOf IκB-α,interacts
R15696 T19667 T19666 themeOf IκB-α,interacted
R15784 T19783 T19781 themeOf recruitment,increased
R15788 T19786 T19785 themeOf p65,associating
R15789 T19787 T19781 causeOf interfering,increased
R15790 T19788 T19787 themeOf assembly,interfering
R10710 T13242 T13246 themeOf Tat,association
R10711 T13244 T13245 themeOf p65,binding
R10712 T13245 T13243 themeOf binding,increases
R10713 T13246 T13243 causeOf association,increases
R10714 T13247 T13246 themeOf p65,association
R10715 T13248 T13249 themeOf Tat,interacted
R10716 T13250 T13249 themeOf p65,interacted
R10717 T13253 T13254 themeOf Tat,immunoprecipitated
R19062 T23899 T23900 themeOf Tat,expression
R19063 T23902 T23904 themeOf p65,binding
R19064 T23903 T23905 themeOf p50,binding
R19065 T23908 T23906 themeOf p65,expression
R19066 T23909 T23907 themeOf IκB-α,expression
R1064 T1244 T1243 equivalentTo p65,RelA
R1069 T1247 T1308 themeOf p50,binding
R1071 T1248 T1309 themeOf p52,binding
R1073 T1249 T1277 causeOf Rel homology domain,for
R1074 T1249 T1276 causeOf Rel homology domain,for
R1075 T1249 T1275 causeOf Rel homology domain,for
R1076 T1249 T1274 causeOf Rel homology domain,for
R1077 T1249 T1273 causeOf Rel homology domain,for
R1078 T1249 T1250 causeOf Rel homology domain,for
R1079 T1249 T1270 causeOf Rel homology domain,for
R1080 T1249 T1269 causeOf Rel homology domain,for
R1081 T1249 T1268 causeOf Rel homology domain,for
R1082 T1249 T1267 causeOf Rel homology domain,for
R1063 T1243 T1307 themeOf RelA,binding
R1066 T1245 T1305 themeOf c-Rel,binding
R1067 T1246 T1304 themeOf RelB,dimerization
R1068 T1246 T1306 themeOf RelB,binding
R1070 T1247 T1303 themeOf p50,dimerization
R1072 T1248 T1300 themeOf p52,dimerization
R1099 T1249 T1290 causeOf Rel homology domain,for
R1100 T1249 T1299 causeOf Rel homology domain,for
R1101 T1249 T1254 causeOf Rel homology domain,for
R1102 T1249 T1258 causeOf Rel homology domain,for
R1103 T1249 T1259 causeOf Rel homology domain,for
R1104 T1249 T1260 causeOf Rel homology domain,for
R1105 T1249 T1261 causeOf Rel homology domain,for
R1106 T1249 T1266 causeOf Rel homology domain,for
R1107 T1249 T1272 causeOf Rel homology domain,for
R1108 T1249 T1278 causeOf Rel homology domain,for
R1109 T1249 T1296 causeOf Rel homology domain,for
R5355 T6285 T6284 themeOf p65,Binding
R5356 T6286 T6283 themeOf p50,Binding
R6963 T8414 T8413 themeOf IκB-α,hijacking
R6964 T8416 T8415 themeOf expression,modulating
R6965 T8417 T8416 themeOf Tat,expression
R6966 T8420 T8422 themeOf expression,increased
R6967 T8420 T8423 themeOf expression,barely detected
R6968 T8421 T8420 themeOf Tat,expression
R6969 T8424 T8423 causeOf siRNA Tat,barely detected
R6970 T8425 T8428 themeOf dependent,induced
R6971 T8426 T8427 themeOf luciferase,expression
R6972 T8427 T8425 themeOf expression,dependent
R6973 T8431 T8434 themeOf p65,binding
R6974 T8432 T8433 themeOf p50,binding
R6975 T8439 T8440 themeOf p65,binding
R6976 T8440 T8443 themeOf binding,elevated
R6978 T8441 T8442 themeOf p65,elevated
R6980 T8444 T8443 causeOf Tat,elevated
R6962 T8412 T8413 themeOf Tat,hijacking
R6977 T8440 T8445 themeOf binding,dropped
R6979 T8441 T8446 themeOf p65,dropped
R6982 T8447 T8445 causeOf absence,dropped
R6983 T8447 T8446 causeOf absence,dropped
R6984 T8448 T8447 themeOf Tat,absence
R6985 T8450 T8451 themeOf IκB-α,degraded
R6986 T8450 T8452 themeOf IκB-α,synthesized
R6987 T8456 T8457 themeOf IκB-α,degradation
R6988 T8456 T8458 themeOf IκB-α,re-synthesis
R6989 T8457 T8460 themeOf degradation,observed
R6990 T8458 T8459 themeOf re-synthesis,observed
R6991 T8461 T8462 themeOf IκB-α,degradation
R6992 T8466 T8465 themeOf IκB-α,synthesis
R6993 T8469 T8470 themeOf p65,binding
R6994 T8470 T8472 themeOf binding,enhanced
R6995 T8471 T8473 themeOf p65,enhanced
R6996 T8474 T8472 causeOf Tat,enhanced
R20919 T26470 T26471 themeOf Tat,associates
R20920 T26471 T26473 causeOf associates,increasing
R20921 T26472 T26471 themeOf p65,associates
R20922 T26472 T26474 themeOf p65,binding
R20923 T26474 T26473 themeOf binding,increasing
R4307 T4898 T4897 equivalentTo TNF-α,tumor necrosis factor-α
R4891 T5673 T5671 themeOf p65,interference
R4892 T5674 T5672 themeOf IκB-α,interference
R19349 T24339 T24340 themeOf Tat,associating
R19350 T24341 T24340 themeOf IκB-α,associating
R19351 T24343 T24347 themeOf p65,binding
R19352 T24344 T24346 themeOf p50,binding
R19353 T24345 T24348 themeOf FLAG-Tat,binding
R9392 T11511 T11516 causeOf Tat,competing
R9394 T11513 T11514 causeOf IκB-α,inhibition
R9395 T11514 T11512 themeOf inhibition,counteracts
R9396 T11515 T11514 themeOf p65,inhibition
R9397 T11516 T11512 causeOf competing,counteracts
R9398 T11517 T11516 themeOf binding,competing
R9416 T11543 T11548 themeOf Tat R(49–57)A,associate
R9417 T11543 T11550 causeOf Tat R(49–57)A,compete
R9420 T11546 T11545 themeOf site,binding
R9421 T11547 T11545 themeOf IκB-α,binding
R9422 T11549 T11548 themeOf IκB-α,associate
R9423 T11551 T11550 themeOf binding,compete
R9424 T11552 T11551 themeOf IκB-α,binding
R9425 T11553 T11551 themeOf p65,binding
R9426 T11554 T11555 causeOf Tat,counteracted
R9427 T11556 T11557 causeOf IκB-α,inhibition
R9428 T11557 T11555 themeOf inhibition,counteracted
R9429 T11558 T11559 themeOf p65,binding
R9430 T11559 T11557 themeOf binding,inhibition
R9431 T11563 T11564 themeOf p65,binding
R9432 T11564 T11565 themeOf binding,inhibited
R9433 T11565 T11568 themeOf inhibited,restored
R9434 T11565 T11567 themeOf inhibited,restored
R9435 T11566 T11565 causeOf IκB-α,inhibited
R9436 T11569 T11568 causeOf Tat,restored
R9437 T11570 T11567 causeOf Tat R(49–57),restored
R9438 T11580 T11581 causeOf IκB-α,inhibited
R9439 T11581 T11586 themeOf inhibited,restored
R9440 T11581 T11587 themeOf inhibited,restored
R9441 T11582 T11583 causeOf p65,dependent
R9442 T11583 T11581 themeOf dependent,inhibited
R9443 T11584 T11583 themeOf expression,dependent
R9444 T11585 T11584 themeOf luciferase,expression
R5898 T7006 T7007 themeOf GAPDH,levels
R5701 T6706 T6709 themeOf HA-IκB-α,expressed
R5702 T6707 T6711 themeOf p65,expressed
R5703 T6708 T6710 themeOf Tat,expressed
R5704 T6709 T6712 themeOf expressed,under
R5705 T6710 T6714 themeOf expressed,under
R5706 T6711 T6713 themeOf expressed,under
R14195 T17705 T17706 themeOf transcriptional,activation
R14196 T17706 T17704 themeOf activation,promotes
R14199 T17710 T17709 themeOf IκB-α,interacting
R14200 T17712 T17713 causeOf Tat,affected
R14201 T17714 T17713 themeOf expression,affected
R14202 T17715 T17714 themeOf MIP-1α,expression
R14203 T17721 T17722 themeOf Tat,expression
R14204 T17722 T17720 themeOf expression,modulate
R22129 T28262 T28266 themeOf Tat,interaction
R22130 T28264 T28265 themeOf MIP-1α,expression
R22131 T28265 T28263 themeOf expression,enhances
R22132 T28266 T28263 causeOf interaction,enhances
R22133 T28267 T28266 themeOf IκB-α,interaction
R22134 T28272 T28273 themeOf Tat,expression
R22135 T28276 T28275 themeOf p65,binding
R22136 T28283 T28284 themeOf MIP-1α,expression
R12069 T15079 T15081 themeOf Tat,occupies
R12117 T15139 T15140 themeOf production,induced
R12118 T15141 T15140 causeOf Tat,induced
R12119 T15142 T15143 themeOf transcriptional,regulation
R12120 T15144 T15142 themeOf MIP-1α,transcriptional
R12121 T15149 T15148 themeOf MIP-1α,expression
R12122 T15150 T15151 themeOf p65,occupancy
R12123 T15152 T15151 themeOf NF-κB sites,occupancy
R12124 T15152 T15149 partOf NF-κB sites,MIP-1α
R12125 T15153 T15154 causeOf TNF-α,activated
R12126 T15153 T15157 causeOf TNF-α,induced
R12127 T15153 T15162 causeOf TNF-α,affecting
R12128 T15155 T15154 themeOf expression,activated
R12129 T15156 T15155 themeOf MIP-1α,expression
R12130 T15158 T15159 themeOf p65,recruitment
R12131 T15158 T15163 themeOf p65,occupancy
R12132 T15159 T15157 themeOf recruitment,induced
R12133 T15160 T15159 themeOf NF-κB1 site,recruitment
R12134 T15160 T15161 partOf NF-κB1 site,MIP-1α
R12135 T15163 T15162 themeOf occupancy,affecting
R12136 T15164 T15165 causeOf Tat,promoted
R12137 T15166 T15165 themeOf recruitment,promoted
R12138 T15167 T15166 themeOf p65,recruitment
R12139 T15168 T15166 themeOf NF-κB1 site,recruitment
R12140 T15168 T15169 partOf NF-κB1 site,MIP-1α
R12143 T15174 T15175 causeOf Tat,increased
R12144 T15174 T15178 causeOf Tat,increased
R20025 T25168 T25169 causeOf Tat,relieves
R20026 T25170 T25172 themeOf p65,inhibition
R20027 T25171 T25172 causeOf IκB-α,inhibition
R20028 T25172 T25169 themeOf inhibition,relieves
R20029 T25187 T25188 themeOf p65,binding
R20030 T25189 T25194 themeOf p65,binding
R20031 T25190 T25193 causeOf HA-IκB-α,competition
R20032 T25194 T25193 themeOf binding,competition
R43 T101 T100 themeOf dependent,activated
R44 T102 T101 themeOf expression,dependent
R45 T103 T104 causeOf bound,promoting
R46 T103 T106 causeOf bound,promoting
R47 T105 T104 themeOf recruitment,promoting
R48 T107 T106 themeOf displacement,promoting
R49 T111 T110 themeOf binding,preventing
R50 T114 T113 themeOf binding,increased
R51 T117 T97 themeOf Tat,interaction
R52 T118 T115 themeOf IκB-α,required
R53 T118 T98 themeOf IκB-α,association
R54 T119 T116 themeOf p65,required
R55 T120 T100 causeOf Tat,activated
R56 T120 T103 themeOf Tat,bound
R57 T121 T101 causeOf p65,dependent
R58 T123 T105 themeOf p65,recruitment
R59 T123 T107 themeOf p65,displacement
R60 T124 T107 themeOf IκB-α,displacement
R61 T127 T97 themeOf IκB-α,interaction
R62 T135 T103 themeOf NF-κB enhancer,bound
R63 T135 T122 partOf NF-κB enhancer,MIP-1α
R64 T135 T105 themeOf NF-κB enhancer,recruitment
R65 T136 T108 themeOf IκB-α,hijacking
R66 T136 T111 themeOf IκB-α,binding
R67 T137 T112 themeOf Tat,associated
R68 T137 T113 causeOf Tat,increased
R69 T138 T112 themeOf p65,associated
R70 T139 T114 themeOf p65,binding
R71 T140 T98 themeOf Tat,association

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T358 31-34 P04608 denotes Tat
T359 31-34 P04605 denotes Tat
T360 31-34 P04610 denotes Tat
T361 31-34 Q8UMQ1 denotes Tat
T362 91-94 P21579 denotes p65
T363 91-94 Q04206 denotes p65
T364 439-442 P04605 denotes Tat
T365 439-442 P04610 denotes Tat
T366 439-442 P04608 denotes Tat
T367 439-442 Q8UMQ1 denotes Tat
T368 579-582 P04610 denotes Tat
T369 579-582 P04608 denotes Tat
T370 579-582 P04605 denotes Tat
T371 579-582 Q8UMQ1 denotes Tat
T372 603-606 Q04206 denotes p65
T373 603-606 P21579 denotes p65
T374 642-645 Q04206 denotes p65
T375 642-645 P21579 denotes p65
T376 740-743 P04610 denotes Tat
T377 740-743 Q8UMQ1 denotes Tat
T378 740-743 P04605 denotes Tat
T379 740-743 P04608 denotes Tat
T380 772-775 P21579 denotes p65
T381 772-775 Q04206 denotes p65
T382 884-887 P04608 denotes Tat
T383 884-887 P04610 denotes Tat
T384 884-887 Q8UMQ1 denotes Tat
T385 884-887 P04605 denotes Tat
T386 909-915 P10147 denotes MIP-1α
T387 932-935 P21579 denotes p65
T388 932-935 Q04206 denotes p65
T389 971-977 P10147 denotes MIP-1α
T390 1027-1030 P21579 denotes p65
T391 1027-1030 Q04206 denotes p65
T392 1121-1125 P09919 denotes CSF3
T393 1127-1130 P01374 denotes LTA
T394 1132-1138 P25963 denotes NFKBIA
T395 1143-1147 O60603 denotes TLR2
T396 1235-1238 Q8UMQ1 denotes Tat
T397 1235-1238 P04608 denotes Tat
T398 1235-1238 P04610 denotes Tat
T399 1235-1238 P04605 denotes Tat
T400 1254-1257 Q04206 denotes p65
T401 1254-1257 P21579 denotes p65
T2244 1543-1547 Q04206-3 denotes RelA
T2245 1543-1547 Q04206 denotes RelA
T2246 1548-1551 Q04206 denotes p65
T2247 1548-1551 P21579 denotes p65
T2248 1553-1558 Q04864 denotes c-Rel
T2249 1555-1558 Q04864 denotes Rel
T2250 1560-1564 Q01201 denotes RelB
T2251 1566-1569 P19838 denotes p50
T2252 1574-1577 Q00653 denotes p52
T2253 1623-1626 Q04864 denotes Rel
T2254 1867-1870 Q04206 denotes p65
T2255 1867-1870 P21579 denotes p65
T2256 1872-1876 Q01201 denotes RelB
T2257 1881-1886 Q04864 denotes c-Rel
T2258 1883-1886 Q04864 denotes Rel
T2259 2054-2064 O15111 denotes IκB kinase
T2260 2054-2064 Q60680-2 denotes IκB kinase
T2261 2492-2495 P21579 denotes p65
T2262 2492-2495 Q04206 denotes p65
T2263 2517-2521 O75582 denotes MSK1
T2264 2591-2594 P21579 denotes p65
T2265 2591-2594 Q04206 denotes p65
T2266 2721-2724 Q04206 denotes p65
T2267 2721-2724 P21579 denotes p65
T2268 2939-2942 P21580 denotes A20
T2269 2969-2972 P21579 denotes p65
T2270 2969-2972 Q04206 denotes p65
T2271 3001-3006 Q96EB6 denotes SIRT1
T2272 3026-3029 P21579 denotes p65
T2273 3026-3029 Q04206 denotes p65
T2274 3849-3852 P01730 denotes CD4
T2275 3982-3985 P04610 denotes Tat
T2276 3982-3985 P04608 denotes Tat
T2277 3982-3985 P04605 denotes Tat
T2278 3982-3985 Q8UMQ1 denotes Tat
T2279 4079-4082 P04608 denotes Tat
T2280 4079-4082 P04610 denotes Tat
T2281 4079-4082 P04605 denotes Tat
T2282 4079-4082 Q8UMQ1 denotes Tat
T2283 4231-4252 P01375 denotes tumor necrosis factor
T2284 4271-4284 P05231 denotes interleukin-6
T2285 4286-4290 P05231 denotes IL-6
T2286 4337-4340 P04610 denotes Tat
T2287 4337-4340 P04608 denotes Tat
T2288 4337-4340 P04605 denotes Tat
T2289 4337-4340 Q8UMQ1 denotes Tat
T2290 4459-4462 P08047 denotes Sp1
T2291 4537-4568 Q09472 denotes histone acetyltransferases p300
T2292 4564-4568 Q09472 denotes p300
T2293 4569-4572 Q92793 denotes CBP
T2294 4579-4582 Q13111 denotes CAF
T2295 4633-4636 Q8UMQ1 denotes Tat
T2296 4633-4636 P04605 denotes Tat
T2297 4633-4636 P04608 denotes Tat
T2298 4633-4636 P04610 denotes Tat
T2299 4872-4875 P04610 denotes Tat
T2300 4872-4875 Q8UMQ1 denotes Tat
T2301 4872-4875 P04608 denotes Tat
T2302 4872-4875 P04605 denotes Tat
T2303 4940-4943 P04605 denotes Tat
T2304 4940-4943 P04608 denotes Tat
T2305 4940-4943 P04610 denotes Tat
T2306 4940-4943 Q8UMQ1 denotes Tat
T2307 5030-5033 Q04206 denotes p65
T2308 5030-5033 P21579 denotes p65
T2309 5110-5113 Q04206 denotes p65
T2310 5110-5113 P21579 denotes p65
T2311 5157-5160 Q8UMQ1 denotes Tat
T2312 5157-5160 P04605 denotes Tat
T2313 5157-5160 P04610 denotes Tat
T2314 5157-5160 P04608 denotes Tat
T2315 5244-5247 P04605 denotes Tat
T2316 5244-5247 Q8UMQ1 denotes Tat
T2317 5244-5247 P04608 denotes Tat
T2318 5244-5247 P04610 denotes Tat
T2319 5399-5402 P04605 denotes Tat
T2320 5399-5402 Q8UMQ1 denotes Tat
T2321 5399-5402 P04610 denotes Tat
T2322 5399-5402 P04608 denotes Tat
T2323 5502-5505 Q8UMQ1 denotes Tat
T2324 5502-5505 P04605 denotes Tat
T2325 5502-5505 P04610 denotes Tat
T2326 5502-5505 P04608 denotes Tat
T2327 5598-5601 Q04206 denotes p65
T2328 5598-5601 P21579 denotes p65
T4549 5900-5903 P04605 denotes Tat
T4550 5900-5903 P04608 denotes Tat
T4551 5900-5903 P04610 denotes Tat
T4552 5900-5903 Q8UMQ1 denotes Tat
T4553 5917-5920 P04608 denotes Tat
T4554 5917-5920 P04605 denotes Tat
T4555 5917-5920 Q8UMQ1 denotes Tat
T4556 5917-5920 P04610 denotes Tat
T4557 5947-5950 P04608 denotes Tat
T4558 5947-5950 P04605 denotes Tat
T4559 5947-5950 P04610 denotes Tat
T4560 5947-5950 Q8UMQ1 denotes Tat
T4561 5982-5985 P04608 denotes Tat
T4562 5982-5985 P04605 denotes Tat
T4563 5982-5985 Q8UMQ1 denotes Tat
T4564 5982-5985 P04610 denotes Tat
T4565 5995-5998 P04608 denotes Tat
T4566 5995-5998 P04605 denotes Tat
T4567 5995-5998 Q8UMQ1 denotes Tat
T4568 5995-5998 P04610 denotes Tat
T4569 6024-6027 P04610 denotes Tat
T4570 6024-6027 P04608 denotes Tat
T4571 6024-6027 P04605 denotes Tat
T4572 6024-6027 Q8UMQ1 denotes Tat
T4573 6121-6124 P04578 denotes env
T4574 6321-6324 P21579 denotes p65
T4575 6321-6324 Q04206 denotes p65
T4576 6394-6397 Q8UMQ1 denotes Tat
T4577 6394-6397 P04610 denotes Tat
T4578 6394-6397 P04608 denotes Tat
T4579 6394-6397 P04605 denotes Tat
T4580 6423-6426 Q8UMQ1 denotes Tat
T4581 6423-6426 P04610 denotes Tat
T4582 6423-6426 P04608 denotes Tat
T4583 6423-6426 P04605 denotes Tat
T4584 6446-6449 Q8UMQ1 denotes Tat
T4585 6446-6449 P04610 denotes Tat
T4586 6446-6449 P04608 denotes Tat
T4587 6446-6449 P04605 denotes Tat
T4588 6471-6474 Q8UMQ1 denotes Tat
T4589 6471-6474 P04610 denotes Tat
T4590 6471-6474 P04608 denotes Tat
T4591 6471-6474 P04605 denotes Tat
T4592 6501-6504 Q8UMQ1 denotes Tat
T4593 6501-6504 P04610 denotes Tat
T4594 6501-6504 P04608 denotes Tat
T4595 6501-6504 P04605 denotes Tat
T5183 6598-6608 P08659 denotes luciferase
T5184 6621-6624 P19838 denotes p50
T5185 6627-6630 Q04206 denotes p65
T5186 6627-6630 P21579 denotes p65
T5187 7015-7018 P19838 denotes p50
T5188 7021-7024 P21579 denotes p65
T5189 7021-7024 Q04206 denotes p65
T5190 7428-7449 P01375 denotes tumor necrosis factor
T5191 7453-7456 P01375 denotes TNF
T5192 7453-7458 P01375 denotes TNF-α
T5193 7572-7582 P08659 denotes luciferase
T5194 7755-7765 P08659 denotes Luciferase
T5195 7808-7818 P08659 denotes luciferase
T5196 7885-7895 P08659 denotes Luciferase
T5197 7993-8003 P08659 denotes luciferase
T5198 8058-8066 Q04864 denotes relative
T5812 8550-8553 P04605 denotes Tat
T5813 8550-8553 P04608 denotes Tat
T5814 8550-8553 P04610 denotes Tat
T5815 8550-8553 Q8UMQ1 denotes Tat
T5816 8593-8596 P04610 denotes Tat
T5817 8593-8596 P04608 denotes Tat
T5818 8593-8596 Q8UMQ1 denotes Tat
T5819 8593-8596 P04605 denotes Tat
T5820 8747-8750 Q04206 denotes p65
T5821 8747-8750 P21579 denotes p65
T5822 8797-8800 Q04206 denotes p65
T5823 8797-8800 P21579 denotes p65
T6297 9625-9627 P0A7Z4 denotes pH
T6298 10391-10394 Q04206 denotes p65
T6299 10391-10394 P21579 denotes p65
T6300 10623-10626 Q04206 denotes p65
T6301 10623-10626 P21579 denotes p65
T6302 10628-10631 P19838 denotes p50
T6303 10641-10644 Q8UMQ1 denotes Tat
T6304 10641-10644 P04610 denotes Tat
T6305 10641-10644 P04608 denotes Tat
T6306 10641-10644 P04605 denotes Tat
T6759 10964-10967 Q04206 denotes p65
T6760 10964-10967 P21579 denotes p65
T6761 10972-10975 Q8UMQ1 denotes Tat
T6762 10972-10975 P04610 denotes Tat
T6763 10972-10975 P04608 denotes Tat
T6764 10972-10975 P04605 denotes Tat
T7186 11934-11937 P04610 denotes Tat
T7187 11934-11937 Q8UMQ1 denotes Tat
T7188 11934-11937 P04605 denotes Tat
T7189 11934-11937 P04608 denotes Tat
T7190 11942-11948 P10147 denotes MIP-1α
T7191 12000-12004 P09919 denotes CSF3
T7192 12006-12009 P01374 denotes LTA
T7193 12011-12017 P25963 denotes NFKBIA
T7194 12019-12023 O60603 denotes TLR2
T7195 12025-12030 P04406 denotes GAPDH
T7196 12035-12039 P60709 denotes ACTB
T7197 12230-12238 Q04864 denotes relative
T7198 12242-12247 P04406 denotes GAPDH
T7199 12283-12291 Q04864 denotes Relative
T7200 12356-12361 P04406 denotes GAPDH
T7530 12702-12704 P0A7Z4 denotes pH
T7531 12901-12903 P0A7Z4 denotes pH
T7532 13141-13143 P0A7Z4 denotes pH
T7533 13376-13379 Q04206 denotes p65
T7534 13376-13379 P21579 denotes p65
T7535 13395-13399 P25963 denotes IκBα
T7536 13674-13676 P0A7Z4 denotes pH
T7537 13783-13785 P0A7Z4 denotes pH
T7538 13879-13881 P0A7Z4 denotes pH
T7539 14484-14490 P10147 denotes MIP-1α
T7540 14492-14497 P04406 denotes GAPDH
T7541 14502-14506 P60709 denotes ACTB
T7542 14558-14562 P09919 denotes CSF3
T7543 14564-14567 P01374 denotes LTA
T7544 14569-14575 P25963 denotes NFKBIA
T7545 14580-14584 O60603 denotes TLR2
T9369 14991-14994 Q8UMQ1 denotes Tat
T9370 14991-14994 P04610 denotes Tat
T9371 14991-14994 P04608 denotes Tat
T9372 14991-14994 P04605 denotes Tat
T9373 15203-15206 Q8UMQ1 denotes Tat
T9374 15203-15206 P04608 denotes Tat
T9375 15203-15206 P04610 denotes Tat
T9376 15203-15206 P04605 denotes Tat
T9377 15271-15274 P04610 denotes Tat
T9378 15271-15274 P04608 denotes Tat
T9379 15271-15274 P04605 denotes Tat
T9380 15271-15274 Q8UMQ1 denotes Tat
T9381 15359-15362 P04578 denotes Env
T9382 15552-15555 P04608 denotes Tat
T9383 15552-15555 P04610 denotes Tat
T9384 15552-15555 P04605 denotes Tat
T9385 15552-15555 Q8UMQ1 denotes Tat
T9386 15722-15725 P04608 denotes Tat
T9387 15722-15725 P04605 denotes Tat
T9388 15722-15725 P04610 denotes Tat
T9389 15722-15725 Q8UMQ1 denotes Tat
T9390 15775-15785 P08659 denotes luciferase
T9391 15949-15952 P04608 denotes Tat
T9392 15949-15952 P04610 denotes Tat
T9393 15949-15952 P04605 denotes Tat
T9394 15949-15952 Q8UMQ1 denotes Tat
T9395 15992-15995 P04605 denotes Tat
T9396 15992-15995 P04608 denotes Tat
T9397 15992-15995 P04610 denotes Tat
T9398 15992-15995 Q8UMQ1 denotes Tat
T9399 17304-17307 P21579 denotes p65
T9400 17304-17307 Q04206 denotes p65
T9401 17308-17311 P19838 denotes p50
T9402 17382-17385 Q04206 denotes p65
T9403 17382-17385 P21579 denotes p65
T9404 17457-17460 P04608 denotes Tat
T9405 17457-17460 P04610 denotes Tat
T9406 17457-17460 Q8UMQ1 denotes Tat
T9407 17457-17460 P04605 denotes Tat
T9408 17502-17505 P04610 denotes Tat
T9409 17502-17505 P04605 denotes Tat
T9410 17502-17505 P04608 denotes Tat
T9411 17502-17505 Q8UMQ1 denotes Tat
T9412 17522-17525 P04608 denotes Tat
T9413 17522-17525 P04610 denotes Tat
T9414 17522-17525 Q8UMQ1 denotes Tat
T9415 17522-17525 P04605 denotes Tat
T9416 17571-17574 Q04206 denotes p65
T9417 17571-17574 P21579 denotes p65
T9418 17599-17602 P21579 denotes p65
T9419 17599-17602 Q04206 denotes p65
T9420 17637-17640 P04605 denotes Tat
T9421 17637-17640 Q8UMQ1 denotes Tat
T9422 17637-17640 P04610 denotes Tat
T9423 17637-17640 P04608 denotes Tat
T9424 17704-17707 P04610 denotes Tat
T9425 17704-17707 P04608 denotes Tat
T9426 17704-17707 P04605 denotes Tat
T9427 17704-17707 Q8UMQ1 denotes Tat
T9428 17715-17718 P04610 denotes Tat
T9429 17715-17718 Q8UMQ1 denotes Tat
T9430 17715-17718 P04608 denotes Tat
T9431 17715-17718 P04605 denotes Tat
T9432 17885-17888 Q8UMQ1 denotes Tat
T9433 17885-17888 P04605 denotes Tat
T9434 17885-17888 P04608 denotes Tat
T9435 17885-17888 P04610 denotes Tat
T9436 17902-17905 Q8UMQ1 denotes Tat
T9437 17902-17905 P04610 denotes Tat
T9438 17902-17905 P04608 denotes Tat
T9439 17902-17905 P04605 denotes Tat
T9440 18078-18081 Q8UMQ1 denotes Tat
T9441 18078-18081 P04610 denotes Tat
T9442 18078-18081 P04608 denotes Tat
T9443 18078-18081 P04605 denotes Tat
T9444 18543-18546 Q8UMQ1 denotes Tat
T9445 18543-18546 P04610 denotes Tat
T9446 18543-18546 P04608 denotes Tat
T9447 18543-18546 P04605 denotes Tat
T9448 18588-18591 P04610 denotes Tat
T9449 18588-18591 P04608 denotes Tat
T9450 18588-18591 P04605 denotes Tat
T9451 18588-18591 Q8UMQ1 denotes Tat
T9452 18697-18700 P04605 denotes Tat
T9453 18697-18700 Q8UMQ1 denotes Tat
T9454 18697-18700 P04610 denotes Tat
T9455 18697-18700 P04608 denotes Tat
T9456 18805-18808 P04608 denotes Tat
T9457 18805-18808 Q8UMQ1 denotes Tat
T9458 18805-18808 P04610 denotes Tat
T9459 18805-18808 P04605 denotes Tat
T9460 18971-18974 P21579 denotes p65
T9461 18971-18974 Q04206 denotes p65
T9462 19011-19014 Q04206 denotes p65
T9463 19011-19014 P21579 denotes p65
T9464 19062-19065 P04608 denotes Tat
T9465 19062-19065 P04610 denotes Tat
T9466 19062-19065 Q8UMQ1 denotes Tat
T9467 19062-19065 P04605 denotes Tat
T9468 19228-19231 P21579 denotes p65
T9469 19228-19231 Q04206 denotes p65
T9470 19296-19299 P04608 denotes Tat
T9471 19296-19299 P04610 denotes Tat
T9472 19296-19299 Q8UMQ1 denotes Tat
T9473 19296-19299 P04605 denotes Tat
T9474 19338-19341 Q04206 denotes p65
T9475 19338-19341 P21579 denotes p65
T9476 19366-19369 Q04206 denotes p65
T9477 19366-19369 P21579 denotes p65
T9478 19418-19421 P04610 denotes Tat
T9479 19418-19421 Q8UMQ1 denotes Tat
T9480 19418-19421 P04608 denotes Tat
T9481 19418-19421 P04605 denotes Tat
T9482 19454-19457 P04610 denotes Tat
T9483 19454-19457 P04605 denotes Tat
T9484 19454-19457 P04608 denotes Tat
T9485 19454-19457 Q8UMQ1 denotes Tat
T9486 19505-19508 P04610 denotes Tat
T9487 19505-19508 P04608 denotes Tat
T9488 19505-19508 P04605 denotes Tat
T9489 19505-19508 Q8UMQ1 denotes Tat
T9490 19860-19863 P04608 denotes Tat
T9491 19860-19863 P04605 denotes Tat
T9492 19860-19863 P04610 denotes Tat
T9493 19860-19863 Q8UMQ1 denotes Tat
T9494 20023-20026 P04605 denotes Tat
T9495 20023-20026 P04608 denotes Tat
T9496 20023-20026 Q8UMQ1 denotes Tat
T9497 20023-20026 P04610 denotes Tat
T9498 20069-20072 P04605 denotes Tat
T9499 20069-20072 P04608 denotes Tat
T9500 20069-20072 P04610 denotes Tat
T9501 20069-20072 Q8UMQ1 denotes Tat
T9502 21841-21844 P04610 denotes Tat
T9503 21841-21844 P04608 denotes Tat
T9504 21841-21844 Q8UMQ1 denotes Tat
T9505 21841-21844 P04605 denotes Tat
T9506 21908-21911 Q8UMQ1 denotes Tat
T9507 21908-21911 P04605 denotes Tat
T9508 21908-21911 P04608 denotes Tat
T9509 21908-21911 P04610 denotes Tat
T9510 22011-22014 P21579 denotes p65
T9511 22011-22014 Q04206 denotes p65
T9512 22232-22235 Q04206 denotes p65
T9513 22232-22235 P21579 denotes p65
T9514 22285-22288 P04605 denotes Tat
T9515 22285-22288 P04608 denotes Tat
T9516 22285-22288 Q8UMQ1 denotes Tat
T9517 22285-22288 P04610 denotes Tat
T9518 22350-22353 P04610 denotes Tat
T9519 22350-22353 P04608 denotes Tat
T9520 22350-22353 Q8UMQ1 denotes Tat
T9521 22350-22353 P04605 denotes Tat
T9522 22376-22379 P04605 denotes Tat
T9523 22376-22379 P04608 denotes Tat
T9524 22376-22379 Q8UMQ1 denotes Tat
T9525 22376-22379 P04610 denotes Tat
T9526 22456-22459 P04608 denotes Tat
T9527 22456-22459 Q8UMQ1 denotes Tat
T9528 22456-22459 P04610 denotes Tat
T9529 22456-22459 P04605 denotes Tat
T9530 22490-22493 Q04206 denotes p65
T9531 22490-22493 P21579 denotes p65
T11967 22496-22499 P04608 denotes Tat
T11968 22496-22499 P04610 denotes Tat
T11969 22496-22499 P04605 denotes Tat
T11970 22496-22499 Q8UMQ1 denotes Tat
T11971 22536-22539 P21579 denotes p65
T11972 22536-22539 Q04206 denotes p65
T11973 22627-22630 P04610 denotes Tat
T11974 22627-22630 Q8UMQ1 denotes Tat
T11975 22627-22630 P04605 denotes Tat
T11976 22627-22630 P04608 denotes Tat
T11977 22769-22772 Q8UMQ1 denotes Tat
T11978 22769-22772 P04610 denotes Tat
T11979 22769-22772 P04608 denotes Tat
T11980 22769-22772 P04605 denotes Tat
T11981 22782-22785 P04608 denotes Tat
T11982 22782-22785 P04610 denotes Tat
T11983 22782-22785 Q8UMQ1 denotes Tat
T11984 22782-22785 P04605 denotes Tat
T11985 22799-22802 P04610 denotes Tat
T11986 22799-22802 P04608 denotes Tat
T11987 22799-22802 P04605 denotes Tat
T11988 22799-22802 Q8UMQ1 denotes Tat
T11989 22817-22820 Q8UMQ1 denotes Tat
T11990 22817-22820 P04610 denotes Tat
T11991 22817-22820 P04608 denotes Tat
T11992 22817-22820 P04605 denotes Tat
T11993 22835-22838 P04608 denotes Tat
T11994 22835-22838 P04610 denotes Tat
T11995 22835-22838 Q8UMQ1 denotes Tat
T11996 22835-22838 P04605 denotes Tat
T11997 22898-22901 Q8UMQ1 denotes Tat
T11998 22898-22901 P04610 denotes Tat
T11999 22898-22901 P04608 denotes Tat
T12000 22898-22901 P04605 denotes Tat
T12001 22919-22922 P04610 denotes Tat
T12002 22919-22922 Q8UMQ1 denotes Tat
T12003 22919-22922 P04608 denotes Tat
T12004 22919-22922 P04605 denotes Tat
T12005 23003-23006 Q8UMQ1 denotes Tat
T12006 23003-23006 P04610 denotes Tat
T12007 23003-23006 P04608 denotes Tat
T12008 23003-23006 P04605 denotes Tat
T12009 23112-23115 Q8UMQ1 denotes Tat
T12010 23112-23115 P04610 denotes Tat
T12011 23112-23115 P04608 denotes Tat
T12012 23112-23115 P04605 denotes Tat
T12013 23172-23175 Q04206 denotes p65
T12014 23172-23175 P21579 denotes p65
T12015 23233-23236 P04610 denotes Tat
T12016 23233-23236 Q8UMQ1 denotes Tat
T12017 23233-23236 P04608 denotes Tat
T12018 23233-23236 P04605 denotes Tat
T12019 23362-23365 Q04206 denotes p65
T12020 23362-23365 P21579 denotes p65
T12021 25511-25514 P04610 denotes Tat
T12022 25511-25514 P04608 denotes Tat
T12023 25511-25514 Q8UMQ1 denotes Tat
T12024 25511-25514 P04605 denotes Tat
T12025 25561-25564 Q04206 denotes p65
T12026 25561-25564 P21579 denotes p65
T12027 25614-25617 Q04206 denotes p65
T12028 25614-25617 P21579 denotes p65
T12029 25684-25687 P04605 denotes Tat
T12030 25684-25687 Q8UMQ1 denotes Tat
T12031 25684-25687 P04608 denotes Tat
T12032 25684-25687 P04610 denotes Tat
T12033 25710-25713 P21579 denotes p65
T12034 25710-25713 Q04206 denotes p65
T12035 25811-25814 P04608 denotes Tat
T12036 25811-25814 Q8UMQ1 denotes Tat
T12037 25811-25814 P04610 denotes Tat
T12038 25811-25814 P04605 denotes Tat
T12039 25827-25830 P04608 denotes Tat
T12040 25827-25830 Q8UMQ1 denotes Tat
T12041 25827-25830 P04610 denotes Tat
T12042 25827-25830 P04605 denotes Tat
T12043 25878-25881 P04608 denotes Tat
T12044 25878-25881 Q8UMQ1 denotes Tat
T12045 25878-25881 P04610 denotes Tat
T12046 25878-25881 P04605 denotes Tat
T12047 25916-25919 Q04206 denotes p65
T12048 25916-25919 P21579 denotes p65
T12049 25961-25964 P19838 denotes p50
T12050 25967-25970 P21579 denotes p65
T12051 25967-25970 Q04206 denotes p65
T12052 26042-26045 P21579 denotes p65
T12053 26042-26045 Q04206 denotes p65
T12054 26083-26086 Q8UMQ1 denotes Tat
T12055 26083-26086 P04610 denotes Tat
T12056 26083-26086 P04605 denotes Tat
T12057 26083-26086 P04608 denotes Tat
T12058 26108-26111 Q04206 denotes p65
T12059 26108-26111 P21579 denotes p65
T12060 26140-26150 P08659 denotes luciferase
T12061 26216-26219 P04610 denotes Tat
T12062 26216-26219 P04608 denotes Tat
T12063 26216-26219 P04605 denotes Tat
T12064 26216-26219 Q8UMQ1 denotes Tat
T12065 26232-26235 Q8UMQ1 denotes Tat
T12066 26232-26235 P04610 denotes Tat
T12067 26232-26235 P04605 denotes Tat
T12068 26232-26235 P04608 denotes Tat
T12069 26299-26302 P04608 denotes Tat
T12070 26299-26302 P04610 denotes Tat
T12071 26299-26302 Q8UMQ1 denotes Tat
T12072 26299-26302 P04605 denotes Tat
T12073 26343-26346 Q04206 denotes p65
T12074 26343-26346 P21579 denotes p65
T12075 26453-26456 Q04206 denotes p65
T12076 26453-26456 P21579 denotes p65
T13723 26459-26462 P04610 denotes Tat
T13724 26459-26462 Q8UMQ1 denotes Tat
T13725 26459-26462 P04605 denotes Tat
T13726 26459-26462 P04608 denotes Tat
T13727 26477-26480 P21579 denotes p65
T13728 26477-26480 Q04206 denotes p65
T13729 26530-26533 Q04206 denotes p65
T13730 26530-26533 P21579 denotes p65
T13731 26552-26555 P04610 denotes Tat
T13732 26552-26555 Q8UMQ1 denotes Tat
T13733 26552-26555 P04608 denotes Tat
T13734 26552-26555 P04605 denotes Tat
T13735 26583-26586 P21579 denotes p65
T13736 26583-26586 Q04206 denotes p65
T13737 26650-26653 P21579 denotes p65
T13738 26650-26653 Q04206 denotes p65
T13739 26663-26666 P04608 denotes Tat
T13740 26663-26666 P04610 denotes Tat
T13741 26663-26666 P04605 denotes Tat
T13742 26663-26666 Q8UMQ1 denotes Tat
T13743 26683-26686 P04610 denotes Tat
T13744 26683-26686 P04608 denotes Tat
T13745 26683-26686 P04605 denotes Tat
T13746 26683-26686 Q8UMQ1 denotes Tat
T13747 26734-26737 P21579 denotes p65
T13748 26734-26737 Q04206 denotes p65
T13749 26786-26789 P04608 denotes Tat
T13750 26786-26789 Q8UMQ1 denotes Tat
T13751 26786-26789 P04610 denotes Tat
T13752 26786-26789 P04605 denotes Tat
T13753 26805-26808 P04610 denotes Tat
T13754 26805-26808 P04608 denotes Tat
T13755 26805-26808 P04605 denotes Tat
T13756 26805-26808 Q8UMQ1 denotes Tat
T13757 26822-26825 P04608 denotes Tat
T13758 26822-26825 P04605 denotes Tat
T13759 26822-26825 P04610 denotes Tat
T13760 26822-26825 Q8UMQ1 denotes Tat
T13761 26840-26843 P04608 denotes Tat
T13762 26840-26843 Q8UMQ1 denotes Tat
T13763 26840-26843 P04605 denotes Tat
T13764 26840-26843 P04610 denotes Tat
T13765 26944-26947 P04608 denotes Tat
T13766 26944-26947 P04605 denotes Tat
T13767 26944-26947 P04610 denotes Tat
T13768 26944-26947 Q8UMQ1 denotes Tat
T13769 27063-27066 P21579 denotes p65
T13770 27063-27066 Q04206 denotes p65
T13771 27080-27083 P04610 denotes Tat
T13772 27080-27083 Q8UMQ1 denotes Tat
T13773 27080-27083 P04605 denotes Tat
T13774 27080-27083 P04608 denotes Tat
T13775 27100-27103 P04605 denotes Tat
T13776 27100-27103 P04608 denotes Tat
T13777 27100-27103 Q8UMQ1 denotes Tat
T13778 27100-27103 P04610 denotes Tat
T13779 27117-27120 P04608 denotes Tat
T13780 27117-27120 P04610 denotes Tat
T13781 27117-27120 P04605 denotes Tat
T13782 27117-27120 Q8UMQ1 denotes Tat
T13783 27135-27138 Q8UMQ1 denotes Tat
T13784 27135-27138 P04610 denotes Tat
T13785 27135-27138 P04605 denotes Tat
T13786 27135-27138 P04608 denotes Tat
T13787 27173-27176 P04610 denotes Tat
T13788 27173-27176 Q8UMQ1 denotes Tat
T13789 27173-27176 P04608 denotes Tat
T13790 27173-27176 P04605 denotes Tat
T13791 27232-27235 P04610 denotes Tat
T13792 27232-27235 P04605 denotes Tat
T13793 27232-27235 Q8UMQ1 denotes Tat
T13794 27232-27235 P04608 denotes Tat
T13795 27252-27255 Q04206 denotes p65
T13796 27252-27255 P21579 denotes p65
T13797 29109-29112 P21579 denotes p65
T13798 29109-29112 Q04206 denotes p65
T13799 29144-29147 Q8UMQ1 denotes Tat
T13800 29144-29147 P04610 denotes Tat
T13801 29144-29147 P04608 denotes Tat
T13802 29144-29147 P04605 denotes Tat
T13803 29187-29190 P04608 denotes Tat
T13804 29187-29190 P04605 denotes Tat
T13805 29187-29190 P04610 denotes Tat
T13806 29187-29190 Q8UMQ1 denotes Tat
T13807 29208-29211 Q04206 denotes p65
T13808 29208-29211 P21579 denotes p65
T13809 29329-29332 P04610 denotes Tat
T13810 29329-29332 P04608 denotes Tat
T13811 29329-29332 Q8UMQ1 denotes Tat
T13812 29329-29332 P04605 denotes Tat
T13813 29443-29446 Q04206 denotes p65
T13814 29443-29446 P21579 denotes p65
T13815 29493-29496 P04605 denotes Tat
T13816 29493-29496 P04610 denotes Tat
T13817 29493-29496 Q8UMQ1 denotes Tat
T13818 29493-29496 P04608 denotes Tat
T13819 29523-29526 P04605 denotes Tat
T13820 29523-29526 P04608 denotes Tat
T13821 29523-29526 P04610 denotes Tat
T13822 29523-29526 Q8UMQ1 denotes Tat
T13823 29534-29537 Q04206 denotes p65
T13824 29534-29537 P21579 denotes p65
T13825 29581-29584 P21579 denotes p65
T13826 29581-29584 Q04206 denotes p65
T13827 29698-29701 P04610 denotes Tat
T13828 29698-29701 P04608 denotes Tat
T13829 29698-29701 P04605 denotes Tat
T13830 29698-29701 Q8UMQ1 denotes Tat
T13831 29705-29708 P04610 denotes Tat
T13832 29705-29708 Q8UMQ1 denotes Tat
T13833 29705-29708 P04608 denotes Tat
T13834 29705-29708 P04605 denotes Tat
T13835 29727-29730 Q04206 denotes p65
T13836 29727-29730 P21579 denotes p65
T13837 29783-29786 P04608 denotes Tat
T13838 29783-29786 P04610 denotes Tat
T13839 29783-29786 P04605 denotes Tat
T13840 29783-29786 Q8UMQ1 denotes Tat
T13841 29826-29829 Q04206 denotes p65
T13842 29826-29829 P21579 denotes p65
T13843 29849-29852 P04610 denotes Tat
T13844 29849-29852 P04608 denotes Tat
T13845 29849-29852 Q8UMQ1 denotes Tat
T13846 29849-29852 P04605 denotes Tat
T13847 29896-29899 Q04206 denotes p65
T13848 29896-29899 P21579 denotes p65
T13849 29934-29937 Q04206 denotes p65
T13850 29934-29937 P21579 denotes p65
T13851 30066-30069 P04608 denotes Tat
T13852 30066-30069 Q8UMQ1 denotes Tat
T13853 30066-30069 P04610 denotes Tat
T13854 30066-30069 P04605 denotes Tat
T13855 30097-30100 Q04206 denotes p65
T13856 30097-30100 P21579 denotes p65
T15833 30145-30148 P04605 denotes Tat
T15834 30145-30148 P04610 denotes Tat
T15835 30145-30148 Q8UMQ1 denotes Tat
T15836 30145-30148 P04608 denotes Tat
T15837 30163-30166 Q04206 denotes p65
T15838 30163-30166 P21579 denotes p65
T15839 30261-30264 Q04206 denotes p65
T15840 30261-30264 P21579 denotes p65
T15841 30327-30330 P04610 denotes Tat
T15842 30327-30330 Q8UMQ1 denotes Tat
T15843 30327-30330 P04608 denotes Tat
T15844 30327-30330 P04605 denotes Tat
T15845 30435-30438 P04610 denotes Tat
T15846 30435-30438 Q8UMQ1 denotes Tat
T15847 30435-30438 P04608 denotes Tat
T15848 30435-30438 P04605 denotes Tat
T15849 30445-30448 Q8UMQ1 denotes Tat
T15850 30445-30448 P04605 denotes Tat
T15851 30445-30448 P04610 denotes Tat
T15852 30445-30448 P04608 denotes Tat
T15853 30470-30473 P04608 denotes Tat
T15854 30470-30473 P04605 denotes Tat
T15855 30470-30473 P04610 denotes Tat
T15856 30470-30473 Q8UMQ1 denotes Tat
T15857 30583-30586 P04610 denotes Tat
T15858 30583-30586 Q8UMQ1 denotes Tat
T15859 30583-30586 P04608 denotes Tat
T15860 30583-30586 P04605 denotes Tat
T15861 30629-30635 P10147 denotes MIP-1α
T15862 30637-30641 P09919 denotes CSF3
T15863 30643-30646 P01374 denotes LTA
T15864 30648-30654 P25963 denotes NFKBIA
T15865 30659-30663 O60603 denotes TLR2
T15866 30683-30686 P04610 denotes Tat
T15867 30683-30686 P04605 denotes Tat
T15868 30683-30686 P04608 denotes Tat
T15869 30683-30686 Q8UMQ1 denotes Tat
T15870 30704-30707 P04610 denotes Tat
T15871 30704-30707 P04605 denotes Tat
T15872 30704-30707 P04608 denotes Tat
T15873 30704-30707 Q8UMQ1 denotes Tat
T15874 30754-30757 P04605 denotes Tat
T15875 30754-30757 P04608 denotes Tat
T15876 30754-30757 P04610 denotes Tat
T15877 30754-30757 Q8UMQ1 denotes Tat
T15878 30866-30869 Q04206 denotes p65
T15879 30866-30869 P21579 denotes p65
T15880 30891-30894 Q8UMQ1 denotes Tat
T15881 30891-30894 P04605 denotes Tat
T15882 30891-30894 P04610 denotes Tat
T15883 30891-30894 P04608 denotes Tat
T15884 30938-30941 P21579 denotes p65
T15885 30938-30941 Q04206 denotes p65
T15886 31016-31021 P04406 denotes GAPDH
T15887 31026-31030 P60709 denotes ACTB
T15888 31063-31066 P04610 denotes Tat
T15889 31063-31066 Q8UMQ1 denotes Tat
T15890 31063-31066 P04608 denotes Tat
T15891 31063-31066 P04605 denotes Tat
T15892 31200-31203 Q8UMQ1 denotes Tat
T15893 31200-31203 P04610 denotes Tat
T15894 31200-31203 P04605 denotes Tat
T15895 31200-31203 P04608 denotes Tat
T15896 31298-31301 Q8UMQ1 denotes Tat
T15897 31298-31301 P04605 denotes Tat
T15898 31298-31301 P04608 denotes Tat
T15899 31298-31301 P04610 denotes Tat
T15900 31369-31372 P21579 denotes p65
T15901 31369-31372 Q04206 denotes p65
T15902 32978-32984 P10147 denotes MIP-1α
T15903 33025-33028 P04610 denotes Tat
T15904 33025-33028 P04608 denotes Tat
T15905 33025-33028 P04605 denotes Tat
T15906 33025-33028 Q8UMQ1 denotes Tat
T15907 33148-33154 P10147 denotes MIP-1α
T15908 33247-33253 P10147 denotes MIP-1α
T15909 33308-33311 P04610 denotes Tat
T15910 33308-33311 Q8UMQ1 denotes Tat
T15911 33308-33311 P04608 denotes Tat
T15912 33308-33311 P04605 denotes Tat
T15913 33366-33372 P10147 denotes MIP-1α
T15914 33535-33541 P10147 denotes MIP-1α
T15915 33723-33729 P10147 denotes MIP-1α
T15916 33770-33773 P01375 denotes TNF
T15917 33770-33775 P01375 denotes TNF-α
T15918 33843-33849 P10147 denotes MIP-1α
T15919 33876-33879 Q04206 denotes p65
T15920 33876-33879 P21579 denotes p65
T15921 33918-33921 P01375 denotes TNF
T15922 33918-33923 P01375 denotes TNF-α
T15923 33952-33958 P10147 denotes MIP-1α
T15924 33975-33978 Q04206 denotes p65
T15925 33975-33978 P21579 denotes p65
T15926 34013-34019 P10147 denotes MIP-1α
T15927 34128-34131 P04608 denotes Tat
T15928 34128-34131 Q8UMQ1 denotes Tat
T15929 34128-34131 P04610 denotes Tat
T15930 34128-34131 P04605 denotes Tat
T15931 34165-34168 Q04206 denotes p65
T15932 34165-34168 P21579 denotes p65
T15933 34191-34197 P10147 denotes MIP-1α
T15934 34389-34395 P10147 denotes MIP-1α
T15935 34420-34423 P01375 denotes TNF
T15936 34420-34425 P01375 denotes TNF-α
T15937 34430-34433 P04610 denotes Tat
T15938 34430-34433 P04608 denotes Tat
T15939 34430-34433 Q8UMQ1 denotes Tat
T15940 34430-34433 P04605 denotes Tat
T15941 34448-34454 P10147 denotes MIP-1α
T15942 34456-34459 P04608 denotes Tat
T15943 34456-34459 P04610 denotes Tat
T15944 34456-34459 Q8UMQ1 denotes Tat
T15945 34456-34459 P04605 denotes Tat
T15946 34489-34492 P21579 denotes p65
T15947 34489-34492 Q04206 denotes p65
T15948 34519-34523 P09919 denotes CSF3
T15949 34525-34528 P01374 denotes LTA
T15950 34530-34536 P25963 denotes NFKBIA
T15951 34541-34545 O60603 denotes TLR2
T15952 34592-34597 P04406 denotes GAPDH
T15953 34602-34606 P60709 denotes ACTB
T15954 34629-34632 P04610 denotes Tat
T15955 34629-34632 P04608 denotes Tat
T15956 34629-34632 P04605 denotes Tat
T15957 34629-34632 Q8UMQ1 denotes Tat
T15958 34689-34694 P04406 denotes GAPDH
T15959 34699-34703 P60709 denotes ACTB
T15960 34746-34749 P21579 denotes p65
T15961 34746-34749 Q04206 denotes p65
T15962 34796-34799 P04610 denotes Tat
T15963 34796-34799 P04605 denotes Tat
T15964 34796-34799 P04608 denotes Tat
T15965 34796-34799 Q8UMQ1 denotes Tat
T15966 34823-34826 P21579 denotes p65
T15967 34823-34826 Q04206 denotes p65
T15968 34940-34943 P04610 denotes Tat
T15969 34940-34943 P04608 denotes Tat
T15970 34940-34943 P04605 denotes Tat
T15971 34940-34943 Q8UMQ1 denotes Tat
T15972 34993-34996 P04610 denotes Tat
T15973 34993-34996 P04605 denotes Tat
T15974 34993-34996 P04608 denotes Tat
T15975 34993-34996 Q8UMQ1 denotes Tat
T15976 35063-35066 P04605 denotes Tat
T15977 35063-35066 P04608 denotes Tat
T15978 35063-35066 P04610 denotes Tat
T15979 35063-35066 Q8UMQ1 denotes Tat
T18173 35128-35131 P04608 denotes Tat
T18174 35128-35131 P04605 denotes Tat
T18175 35128-35131 Q8UMQ1 denotes Tat
T18176 35128-35131 P04610 denotes Tat
T18177 35207-35213 P10147 denotes MIP-1α
T18178 35244-35247 P21579 denotes p65
T18179 35244-35247 Q04206 denotes p65
T18180 35273-35276 P04610 denotes Tat
T18181 35273-35276 P04608 denotes Tat
T18182 35273-35276 Q8UMQ1 denotes Tat
T18183 35273-35276 P04605 denotes Tat
T18184 35327-35333 P10147 denotes MIP-1α
T18185 35382-35385 P04610 denotes Tat
T18186 35382-35385 Q8UMQ1 denotes Tat
T18187 35382-35385 P04608 denotes Tat
T18188 35382-35385 P04605 denotes Tat
T18189 35412-35415 P04578 denotes Env
T18190 35439-35442 P04605 denotes Tat
T18191 35439-35442 P04608 denotes Tat
T18192 35439-35442 P04610 denotes Tat
T18193 35439-35442 Q8UMQ1 denotes Tat
T18194 35571-35574 P04610 denotes Tat
T18195 35571-35574 P04608 denotes Tat
T18196 35571-35574 P04605 denotes Tat
T18197 35571-35574 Q8UMQ1 denotes Tat
T18198 35628-35631 P04610 denotes Tat
T18199 35628-35631 P04608 denotes Tat
T18200 35628-35631 P04605 denotes Tat
T18201 35628-35631 Q8UMQ1 denotes Tat
T18202 35743-35746 P04610 denotes Tat
T18203 35743-35746 P04608 denotes Tat
T18204 35743-35746 Q8UMQ1 denotes Tat
T18205 35743-35746 P04605 denotes Tat
T18206 35751-35754 P04585 denotes p24
T18207 35751-35754 P03366 denotes p24
T18208 35751-35754 P04591 denotes p24
T18209 35751-35754 P12497 denotes p24
T18210 35836-35839 P04610 denotes Tat
T18211 35836-35839 P04605 denotes Tat
T18212 35836-35839 P04608 denotes Tat
T18213 35836-35839 Q8UMQ1 denotes Tat
T18214 38161-38164 Q04206 denotes p65
T18215 38161-38164 P21579 denotes p65
T18216 38220-38223 P04608 denotes Tat
T18217 38220-38223 P04610 denotes Tat
T18218 38220-38223 P04605 denotes Tat
T18219 38220-38223 Q8UMQ1 denotes Tat
T18220 38266-38269 Q8UMQ1 denotes Tat
T18221 38266-38269 P04610 denotes Tat
T18222 38266-38269 P04608 denotes Tat
T18223 38266-38269 P04605 denotes Tat
T18224 38292-38295 Q8UMQ1 denotes Tat
T18225 38292-38295 P04608 denotes Tat
T18226 38292-38295 P04610 denotes Tat
T18227 38292-38295 P04605 denotes Tat
T18228 38328-38331 Q8UMQ1 denotes Tat
T18229 38328-38331 P04610 denotes Tat
T18230 38328-38331 P04608 denotes Tat
T18231 38328-38331 P04605 denotes Tat
T18232 38493-38496 Q8UMQ1 denotes Tat
T18233 38493-38496 P04610 denotes Tat
T18234 38493-38496 P04605 denotes Tat
T18235 38493-38496 P04608 denotes Tat
T18236 38628-38631 Q8UMQ1 denotes Tat
T18237 38628-38631 P04610 denotes Tat
T18238 38628-38631 P04608 denotes Tat
T18239 38628-38631 P04605 denotes Tat
T18240 38928-38931 P04605 denotes Tat
T18241 38928-38931 P04610 denotes Tat
T18242 38928-38931 Q8UMQ1 denotes Tat
T18243 38928-38931 P04608 denotes Tat
T18244 38972-38975 P21579 denotes p65
T18245 38972-38975 Q04206 denotes p65
T18246 39007-39013 P10147 denotes MIP-1α
T18247 39030-39033 P21579 denotes p65
T18248 39030-39033 Q04206 denotes p65
T18249 39113-39116 P04610 denotes Tat
T18250 39113-39116 P04608 denotes Tat
T18251 39113-39116 P04605 denotes Tat
T18252 39113-39116 Q8UMQ1 denotes Tat
T18253 39120-39123 P21579 denotes p65
T18254 39120-39123 Q04206 denotes p65
T18255 39147-39150 Q8UMQ1 denotes Tat
T18256 39147-39150 P04610 denotes Tat
T18257 39147-39150 P04605 denotes Tat
T18258 39147-39150 P04608 denotes Tat
T18259 39155-39158 Q04206 denotes p65
T18260 39155-39158 P21579 denotes p65
T18261 39204-39210 P10147 denotes MIP-1α
T18262 39222-39225 P21579 denotes p65
T18263 39222-39225 Q04206 denotes p65
T18264 39259-39262 P04608 denotes Tat
T18265 39259-39262 P04610 denotes Tat
T18266 39259-39262 Q8UMQ1 denotes Tat
T18267 39259-39262 P04605 denotes Tat
T18268 39354-39357 P04608 denotes Tat
T18269 39354-39357 Q8UMQ1 denotes Tat
T18270 39354-39357 P04610 denotes Tat
T18271 39354-39357 P04605 denotes Tat
T18272 39384-39387 P21579 denotes p65
T18273 39384-39387 Q04206 denotes p65
T18274 39405-39408 P21579 denotes p65
T18275 39405-39408 Q04206 denotes p65
T18276 39433-39439 P10147 denotes MIP-1α
T18277 39476-39482 P10147 denotes MIP-1α
T18278 39521-39524 Q04206 denotes p65
T18279 39521-39524 P21579 denotes p65
T20969 39608-39611 P04608 denotes Tat
T20970 39608-39611 Q8UMQ1 denotes Tat
T20971 39608-39611 P04610 denotes Tat
T20972 39608-39611 P04605 denotes Tat
T20973 39655-39658 P04610 denotes Tat
T20974 39655-39658 P04608 denotes Tat
T20975 39655-39658 Q8UMQ1 denotes Tat
T20976 39655-39658 P04605 denotes Tat
T20977 39704-39707 P21579 denotes p65
T20978 39704-39707 Q04206 denotes p65
T20979 39834-39837 P04610 denotes Tat
T20980 39834-39837 P04608 denotes Tat
T20981 39834-39837 P04605 denotes Tat
T20982 39834-39837 Q8UMQ1 denotes Tat
T20983 39897-39900 Q04206 denotes p65
T20984 39897-39900 P21579 denotes p65
T20985 40018-40021 Q8UMQ1 denotes Tat
T20986 40018-40021 P04608 denotes Tat
T20987 40018-40021 P04605 denotes Tat
T20988 40018-40021 P04610 denotes Tat
T20989 40319-40322 Q8UMQ1 denotes Tat
T20990 40319-40322 P04610 denotes Tat
T20991 40319-40322 P04608 denotes Tat
T20992 40319-40322 P04605 denotes Tat
T20993 40448-40451 P04608 denotes Tat
T20994 40448-40451 Q8UMQ1 denotes Tat
T20995 40448-40451 P04610 denotes Tat
T20996 40448-40451 P04605 denotes Tat
T20997 40503-40506 P04610 denotes Tat
T20998 40503-40506 P04608 denotes Tat
T20999 40503-40506 Q8UMQ1 denotes Tat
T21000 40503-40506 P04605 denotes Tat
T21001 40575-40578 P04610 denotes Tat
T21002 40575-40578 Q8UMQ1 denotes Tat
T21003 40575-40578 P04608 denotes Tat
T21004 40575-40578 P04605 denotes Tat
T21005 40742-40745 P04610 denotes Tat
T21006 40742-40745 P04608 denotes Tat
T21007 40742-40745 P04605 denotes Tat
T21008 40742-40745 Q8UMQ1 denotes Tat
T21009 40776-40779 P04610 denotes Tat
T21010 40776-40779 P04608 denotes Tat
T21011 40776-40779 P04605 denotes Tat
T21012 40776-40779 Q8UMQ1 denotes Tat
T21013 40872-40875 P04605 denotes Tat
T21014 40872-40875 Q8UMQ1 denotes Tat
T21015 40872-40875 P04610 denotes Tat
T21016 40872-40875 P04608 denotes Tat
T21017 41021-41024 P21579 denotes p65
T21018 41021-41024 Q04206 denotes p65
T21019 41066-41069 P04610 denotes Tat
T21020 41066-41069 P04608 denotes Tat
T21021 41066-41069 Q8UMQ1 denotes Tat
T21022 41066-41069 P04605 denotes Tat
T21023 41107-41110 P21579 denotes p65
T21024 41107-41110 Q04206 denotes p65
T21025 41149-41152 Q04206 denotes p65
T21026 41149-41152 P21579 denotes p65
T21027 41199-41202 Q8UMQ1 denotes Tat
T21028 41199-41202 P04608 denotes Tat
T21029 41199-41202 P04610 denotes Tat
T21030 41199-41202 P04605 denotes Tat
T21031 41219-41222 Q04206 denotes p65
T21032 41219-41222 P21579 denotes p65
T21033 41241-41244 P21579 denotes p65
T21034 41241-41244 Q04206 denotes p65
T21035 41378-41381 Q04206 denotes p65
T21036 41378-41381 P21579 denotes p65
T21037 41434-41437 P04605 denotes Tat
T21038 41434-41437 Q8UMQ1 denotes Tat
T21039 41434-41437 P04610 denotes Tat
T21040 41434-41437 P04608 denotes Tat
T21041 41486-41489 P21579 denotes p65
T21042 41486-41489 Q04206 denotes p65
T21043 41521-41524 P04610 denotes Tat
T21044 41521-41524 P04608 denotes Tat
T21045 41521-41524 P04605 denotes Tat
T21046 41521-41524 Q8UMQ1 denotes Tat
T21047 41602-41605 P21579 denotes p65
T21048 41602-41605 Q04206 denotes p65
T21049 41645-41648 Q8UMQ1 denotes Tat
T21050 41645-41648 P04608 denotes Tat
T21051 41645-41648 P04610 denotes Tat
T21052 41645-41648 P04605 denotes Tat
T21053 41779-41782 P21579 denotes p65
T21054 41779-41782 Q04206 denotes p65
T21055 41853-41856 P04610 denotes Tat
T21056 41853-41856 P04608 denotes Tat
T21057 41853-41856 Q8UMQ1 denotes Tat
T21058 41853-41856 P04605 denotes Tat
T21059 41953-41956 P21579 denotes p65
T21060 41953-41956 Q04206 denotes p65
T21061 41999-42002 Q04206 denotes p65
T21062 41999-42002 P21579 denotes p65
T21063 42039-42042 P04610 denotes Tat
T21064 42039-42042 P04608 denotes Tat
T21065 42039-42042 Q8UMQ1 denotes Tat
T21066 42039-42042 P04605 denotes Tat
T21067 42085-42088 P04610 denotes Tat
T21068 42085-42088 P04608 denotes Tat
T21069 42085-42088 P04605 denotes Tat
T21070 42085-42088 Q8UMQ1 denotes Tat
T21071 42102-42105 P04610 denotes Tat
T21072 42102-42105 Q8UMQ1 denotes Tat
T21073 42102-42105 P04605 denotes Tat
T21074 42102-42105 P04608 denotes Tat
T21075 42247-42253 P10147 denotes MIP-1α
T21076 42255-42259 P09919 denotes CSF3
T21077 42261-42264 P01374 denotes LTA
T21078 42266-42272 P25963 denotes NFKBIA
T21079 42277-42281 O60603 denotes TLR2
T21080 42318-42321 P04605 denotes Tat
T21081 42318-42321 P04608 denotes Tat
T21082 42318-42321 P04610 denotes Tat
T21083 42318-42321 Q8UMQ1 denotes Tat
T21084 42351-42354 Q04206 denotes p65
T21085 42351-42354 P21579 denotes p65
T21086 42459-42462 Q04206 denotes p65
T21087 42459-42462 P21579 denotes p65
T21088 42477-42480 Q8UMQ1 denotes Tat
T21089 42477-42480 P04610 denotes Tat
T21090 42477-42480 P04608 denotes Tat
T21091 42477-42480 P04605 denotes Tat
T21092 42534-42537 P04610 denotes Tat
T21093 42534-42537 Q8UMQ1 denotes Tat
T21094 42534-42537 P04608 denotes Tat
T21095 42534-42537 P04605 denotes Tat
T21096 42581-42584 Q04206 denotes p65
T21097 42581-42584 P21579 denotes p65
T21098 42639-42642 P04610 denotes Tat
T21099 42639-42642 P04608 denotes Tat
T21100 42639-42642 P04605 denotes Tat
T21101 42639-42642 Q8UMQ1 denotes Tat
T21102 42653-42656 Q04206 denotes p65
T21103 42653-42656 P21579 denotes p65
T21104 42722-42725 Q04206 denotes p65
T21105 42722-42725 P21579 denotes p65
T21106 42792-42795 P04610 denotes Tat
T21107 42792-42795 P04605 denotes Tat
T21108 42792-42795 Q8UMQ1 denotes Tat
T21109 42792-42795 P04608 denotes Tat
T21110 42832-42835 Q04206 denotes p65
T21111 42832-42835 P21579 denotes p65
T21112 42889-42892 P21579 denotes p65
T21113 42889-42892 Q04206 denotes p65
T21114 42933-42936 Q04206 denotes p65
T21115 42933-42936 P21579 denotes p65
T21116 43040-43043 P04608 denotes Tat
T21117 43040-43043 P04605 denotes Tat
T21118 43040-43043 Q8UMQ1 denotes Tat
T21119 43040-43043 P04610 denotes Tat
T21120 43083-43086 P04608 denotes Tat
T21121 43083-43086 P04610 denotes Tat
T21122 43083-43086 Q8UMQ1 denotes Tat
T21123 43083-43086 P04605 denotes Tat
T21124 43325-43328 P01375 denotes TNF
T21125 43325-43330 P01375 denotes TNF-α
T21126 43523-43526 P04605 denotes Tat
T21127 43523-43526 P04608 denotes Tat
T21128 43523-43526 P04610 denotes Tat
T21129 43523-43526 Q8UMQ1 denotes Tat
T21130 43598-43601 P21579 denotes p65
T21131 43598-43601 Q04206 denotes p65
T21132 44076-44079 P04608 denotes Tat
T21133 44076-44079 P04610 denotes Tat
T21134 44076-44079 P04605 denotes Tat
T21135 44076-44079 Q8UMQ1 denotes Tat
T21136 44182-44185 P04605 denotes Tat
T21137 44182-44185 Q8UMQ1 denotes Tat
T21138 44182-44185 P04610 denotes Tat
T21139 44182-44185 P04608 denotes Tat
T21140 44287-44290 Q8UMQ1 denotes Tat
T21141 44287-44290 P04610 denotes Tat
T21142 44287-44290 P04608 denotes Tat
T21143 44287-44290 P04605 denotes Tat
T21144 44361-44364 P04605 denotes Tat
T21145 44361-44364 P04608 denotes Tat
T21146 44361-44364 Q8UMQ1 denotes Tat
T21147 44361-44364 P04610 denotes Tat
T21148 44380-44383 P21579 denotes p65
T21149 44380-44383 Q04206 denotes p65
T21150 44404-44410 P10147 denotes MIP-1α
T21151 44435-44438 P04608 denotes Tat
T21152 44435-44438 P04610 denotes Tat
T21153 44435-44438 Q8UMQ1 denotes Tat
T21154 44435-44438 P04605 denotes Tat
T21155 44443-44446 P21579 denotes p65
T21156 44443-44446 Q04206 denotes p65
T21157 44453-44456 P04610 denotes Tat
T21158 44453-44456 Q8UMQ1 denotes Tat
T21159 44453-44456 P04608 denotes Tat
T21160 44453-44456 P04605 denotes Tat
T21161 44474-44480 P10147 denotes MIP-1α
T21162 44537-44540 P21579 denotes p65
T21163 44537-44540 Q04206 denotes p65
T21164 44593-44596 P04605 denotes Tat
T21165 44593-44596 P04610 denotes Tat
T21166 44593-44596 P04608 denotes Tat
T21167 44593-44596 Q8UMQ1 denotes Tat
T21168 44631-44634 Q04206 denotes p65
T21169 44631-44634 P21579 denotes p65
T21170 44781-44785 P05231 denotes IL-6
T21171 44795-44798 P01375 denotes TNF
T21172 44795-44800 P01375 denotes TNF-α
T21173 44811-44817 P10147 denotes MIP-1α
T21174 44848-44851 P01375 denotes TNF
T21175 44848-44853 P01375 denotes TNF-α
T21176 44858-44862 P05231 denotes IL-6
T21177 44864-44867 P04605 denotes Tat
T21178 44864-44867 P04608 denotes Tat
T21179 44864-44867 P04610 denotes Tat
T21180 44864-44867 Q8UMQ1 denotes Tat
T21181 45055-45058 P04608 denotes Tat
T21182 45055-45058 P04605 denotes Tat
T21183 45055-45058 Q8UMQ1 denotes Tat
T21184 45055-45058 P04610 denotes Tat
T21185 45159-45162 P04608 denotes Tat
T21186 45159-45162 P04610 denotes Tat
T21187 45159-45162 P04605 denotes Tat
T21188 45159-45162 Q8UMQ1 denotes Tat
T21189 45168-45171 P21579 denotes p65
T21190 45168-45171 Q04206 denotes p65
T21191 45299-45302 P04608 denotes Tat
T21192 45299-45302 Q8UMQ1 denotes Tat
T21193 45299-45302 P04610 denotes Tat
T21194 45299-45302 P04605 denotes Tat
T21195 45412-45415 P04605 denotes Tat
T21196 45412-45415 P04608 denotes Tat
T21197 45412-45415 P04610 denotes Tat
T21198 45412-45415 Q8UMQ1 denotes Tat
T21199 46088-46091 P04605 denotes Tat
T21200 46088-46091 Q8UMQ1 denotes Tat
T21201 46088-46091 P04610 denotes Tat
T21202 46088-46091 P04608 denotes Tat
T21203 46150-46153 Q04206 denotes p65
T21204 46150-46153 P21579 denotes p65
T21205 46204-46207 P04608 denotes Tat
T21206 46204-46207 P04610 denotes Tat
T21207 46204-46207 Q8UMQ1 denotes Tat
T21208 46204-46207 P04605 denotes Tat
T23916 16062-16065 P04605 denotes Tat
T23917 16062-16065 P04610 denotes Tat
T23918 16062-16065 P04608 denotes Tat
T23919 16062-16065 Q8UMQ1 denotes Tat
T23920 16200-16203 P04605 denotes Tat
T23921 16200-16203 P04610 denotes Tat
T23922 16200-16203 Q8UMQ1 denotes Tat
T23923 16200-16203 P04608 denotes Tat
T23924 16342-16345 P04591 denotes p24
T23925 16342-16345 P03366 denotes p24
T23926 16342-16345 P12497 denotes p24
T23927 16342-16345 P04585 denotes p24
T23928 16388-16391 P04608 denotes Tat
T23929 16388-16391 Q8UMQ1 denotes Tat
T23930 16388-16391 P04610 denotes Tat
T23931 16388-16391 P04605 denotes Tat
T23932 16457-16467 P08659 denotes luciferase
T23933 16565-16568 Q04206 denotes p65
T23934 16565-16568 P21579 denotes p65
T23935 16573-16576 P19838 denotes p50
T23936 16715-16718 P21579 denotes p65
T23937 16715-16718 Q04206 denotes p65
T23938 16831-16834 Q04206 denotes p65
T23939 16831-16834 P21579 denotes p65
T24641 20207-20210 Q8UMQ1 denotes Tat
T24642 20207-20210 P04610 denotes Tat
T24643 20207-20210 P04608 denotes Tat
T24644 20207-20210 P04605 denotes Tat
T24645 20382-20385 P04605 denotes Tat
T24646 20382-20385 P04610 denotes Tat
T24647 20382-20385 P04608 denotes Tat
T24648 20382-20385 Q8UMQ1 denotes Tat
T24649 20669-20672 Q04206 denotes p65
T24650 20669-20672 P21579 denotes p65
T24651 20674-20677 P19838 denotes p50
T24652 20687-20690 P04608 denotes Tat
T24653 20687-20690 P04605 denotes Tat
T24654 20687-20690 P04610 denotes Tat
T24655 20687-20690 Q8UMQ1 denotes Tat
T24656 20929-20932 P21579 denotes p65
T24657 20929-20932 Q04206 denotes p65
T24658 21294-21297 P04608 denotes Tat
T24659 21294-21297 Q8UMQ1 denotes Tat
T24660 21294-21297 P04610 denotes Tat
T24661 21294-21297 P04605 denotes Tat
T24662 21637-21640 Q04206 denotes p65
T24663 21637-21640 P21579 denotes p65
T25592 23400-23403 P04608 denotes Tat
T25593 23400-23403 Q8UMQ1 denotes Tat
T25594 23400-23403 P04610 denotes Tat
T25595 23400-23403 P04605 denotes Tat
T25596 23413-23416 Q04206 denotes p65
T25597 23413-23416 P21579 denotes p65
T25598 23497-23500 P04605 denotes Tat
T25599 23497-23500 Q8UMQ1 denotes Tat
T25600 23497-23500 P04610 denotes Tat
T25601 23497-23500 P04608 denotes Tat
T25602 23576-23579 P04605 denotes Tat
T25603 23576-23579 P04608 denotes Tat
T25604 23576-23579 Q8UMQ1 denotes Tat
T25605 23576-23579 P04610 denotes Tat
T25606 23586-23589 Q8UMQ1 denotes Tat
T25607 23586-23589 P04610 denotes Tat
T25608 23586-23589 P04608 denotes Tat
T25609 23586-23589 P04605 denotes Tat
T25610 23608-23611 Q8UMQ1 denotes Tat
T25611 23608-23611 P04610 denotes Tat
T25612 23608-23611 P04608 denotes Tat
T25613 23608-23611 P04605 denotes Tat
T25614 23628-23631 P04610 denotes Tat
T25615 23628-23631 P04608 denotes Tat
T25616 23628-23631 P04605 denotes Tat
T25617 23628-23631 Q8UMQ1 denotes Tat
T25618 23650-23653 P04610 denotes Tat
T25619 23650-23653 Q8UMQ1 denotes Tat
T25620 23650-23653 P04608 denotes Tat
T25621 23650-23653 P04605 denotes Tat
T25622 23732-23735 Q8UMQ1 denotes Tat
T25623 23732-23735 P04608 denotes Tat
T25624 23732-23735 P04610 denotes Tat
T25625 23732-23735 P04605 denotes Tat
T25626 23940-23943 P21579 denotes p65
T25627 23940-23943 Q04206 denotes p65
T25628 24037-24040 Q8UMQ1 denotes Tat
T25629 24037-24040 P04605 denotes Tat
T25630 24037-24040 P04608 denotes Tat
T25631 24037-24040 P04610 denotes Tat
T25632 24049-24052 P04610 denotes Tat
T25633 24049-24052 P04608 denotes Tat
T25634 24049-24052 P04605 denotes Tat
T25635 24049-24052 Q8UMQ1 denotes Tat
T25636 24283-24286 P21579 denotes p65
T25637 24283-24286 Q04206 denotes p65
T25638 24394-24397 Q04206 denotes p65
T25639 24394-24397 P21579 denotes p65
T25640 24545-24548 P21579 denotes p65
T25641 24545-24548 Q04206 denotes p65
T25642 24606-24609 P04610 denotes Tat
T25643 24606-24609 Q8UMQ1 denotes Tat
T25644 24606-24609 P04608 denotes Tat
T25645 24606-24609 P04605 denotes Tat
T25646 24618-24621 Q8UMQ1 denotes Tat
T25647 24618-24621 P04608 denotes Tat
T25648 24618-24621 P04610 denotes Tat
T25649 24618-24621 P04605 denotes Tat
T25650 24861-24864 P19838 denotes p50
T25651 24867-24870 Q04206 denotes p65
T25652 24867-24870 P21579 denotes p65
T25653 24979-24982 Q04206 denotes p65
T25654 24979-24982 P21579 denotes p65
T25655 25026-25029 Q8UMQ1 denotes Tat
T25656 25026-25029 P04608 denotes Tat
T25657 25026-25029 P04610 denotes Tat
T25658 25026-25029 P04605 denotes Tat
T25659 25041-25044 Q8UMQ1 denotes Tat
T25660 25041-25044 P04610 denotes Tat
T25661 25041-25044 P04608 denotes Tat
T25662 25041-25044 P04605 denotes Tat
T25663 25078-25088 P08659 denotes luciferase
T25664 25226-25234 Q04864 denotes relative
T25665 25429-25432 P21579 denotes p65
T25666 25429-25432 Q04206 denotes p65
T26505 27379-27382 P04610 denotes Tat
T26506 27379-27382 Q8UMQ1 denotes Tat
T26507 27379-27382 P04605 denotes Tat
T26508 27379-27382 P04608 denotes Tat
T26509 27399-27402 P21579 denotes p65
T26510 27399-27402 Q04206 denotes p65
T26511 27490-27493 P21579 denotes p65
T26512 27490-27493 Q04206 denotes p65
T26513 27535-27538 P04605 denotes Tat
T26514 27535-27538 P04608 denotes Tat
T26515 27535-27538 P04610 denotes Tat
T26516 27535-27538 Q8UMQ1 denotes Tat
T26517 27548-27551 P04610 denotes Tat
T26518 27548-27551 P04608 denotes Tat
T26519 27548-27551 P04605 denotes Tat
T26520 27548-27551 Q8UMQ1 denotes Tat
T26521 27573-27576 P04608 denotes Tat
T26522 27573-27576 P04605 denotes Tat
T26523 27573-27576 P04610 denotes Tat
T26524 27573-27576 Q8UMQ1 denotes Tat
T26525 27596-27599 Q8UMQ1 denotes Tat
T26526 27596-27599 P04610 denotes Tat
T26527 27596-27599 P04608 denotes Tat
T26528 27596-27599 P04605 denotes Tat
T26529 27622-27625 Q8UMQ1 denotes Tat
T26530 27622-27625 P04610 denotes Tat
T26531 27622-27625 P04608 denotes Tat
T26532 27622-27625 P04605 denotes Tat
T26533 27652-27655 Q8UMQ1 denotes Tat
T26534 27652-27655 P04610 denotes Tat
T26535 27652-27655 P04608 denotes Tat
T26536 27652-27655 P04605 denotes Tat
T26537 27856-27859 P21579 denotes p65
T26538 27856-27859 Q04206 denotes p65
T26539 27890-27893 P04608 denotes Tat
T26540 27890-27893 P04605 denotes Tat
T26541 27890-27893 P04610 denotes Tat
T26542 27890-27893 Q8UMQ1 denotes Tat
T26543 27899-27902 P04605 denotes Tat
T26544 27899-27902 P04610 denotes Tat
T26545 27899-27902 P04608 denotes Tat
T26546 27899-27902 Q8UMQ1 denotes Tat
T26547 27920-27923 P04610 denotes Tat
T26548 27920-27923 P04608 denotes Tat
T26549 27920-27923 P04605 denotes Tat
T26550 27920-27923 Q8UMQ1 denotes Tat
T26551 27939-27942 Q8UMQ1 denotes Tat
T26552 27939-27942 P04608 denotes Tat
T26553 27939-27942 P04610 denotes Tat
T26554 27939-27942 P04605 denotes Tat
T26555 27958-27961 P04610 denotes Tat
T26556 27958-27961 Q8UMQ1 denotes Tat
T26557 27958-27961 P04608 denotes Tat
T26558 27958-27961 P04605 denotes Tat
T26559 28150-28153 P21579 denotes p65
T26560 28150-28153 Q04206 denotes p65
T26561 28231-28234 Q04206 denotes p65
T26562 28231-28234 P21579 denotes p65
T26563 28290-28293 P04608 denotes Tat
T26564 28290-28293 P04610 denotes Tat
T26565 28290-28293 Q8UMQ1 denotes Tat
T26566 28290-28293 P04605 denotes Tat
T26567 28344-28347 P21579 denotes p65
T26568 28344-28347 Q04206 denotes p65
T26569 28441-28444 Q04206 denotes p65
T26570 28441-28444 P21579 denotes p65
T26571 28635-28638 P21579 denotes p65
T26572 28635-28638 Q04206 denotes p65
T26573 28815-28818 Q8UMQ1 denotes Tat
T26574 28815-28818 P04610 denotes Tat
T26575 28815-28818 P04608 denotes Tat
T26576 28815-28818 P04605 denotes Tat
T26577 28827-28830 Q8UMQ1 denotes Tat
T26578 28827-28830 P04610 denotes Tat
T26579 28827-28830 P04608 denotes Tat
T26580 28827-28830 P04605 denotes Tat
T27570 31394-31397 P04608 denotes Tat
T27571 31394-31397 P04610 denotes Tat
T27572 31394-31397 Q8UMQ1 denotes Tat
T27573 31394-31397 P04605 denotes Tat
T27574 31412-31415 Q04206 denotes p65
T27575 31412-31415 P21579 denotes p65
T27600 31951-31954 P01374 denotes LTA
T27601 31960-31966 P25963 denotes NFKBIA
T27602 31972-31976 O60603 denotes TLR2
T27603 31982-31987 P04406 denotes GAPDH
T27604 31993-31997 P60709 denotes ACTB
T27605 32064-32067 P04610 denotes Tat
T27606 32064-32067 P04605 denotes Tat
T27607 32064-32067 P04608 denotes Tat
T27608 32064-32067 Q8UMQ1 denotes Tat
T27609 32137-32140 Q04206 denotes p65
T27610 32137-32140 P21579 denotes p65
T27611 32302-32305 Q8UMQ1 denotes Tat
T27612 32302-32305 P04605 denotes Tat
T27613 32302-32305 P04610 denotes Tat
T27614 32302-32305 P04608 denotes Tat
T27615 32346-32349 Q04206 denotes p65
T27616 32346-32349 P21579 denotes p65
T27617 32584-32587 P04610 denotes Tat
T27618 32584-32587 Q8UMQ1 denotes Tat
T27619 32584-32587 P04608 denotes Tat
T27620 32584-32587 P04605 denotes Tat
T28299 35900-35903 Q8UMQ1 denotes Tat
T28300 35900-35903 P04608 denotes Tat
T28301 35900-35903 P04610 denotes Tat
T28302 35900-35903 P04605 denotes Tat
T28303 35949-35955 P10147 denotes MIP-1α
T28304 35998-36001 P21579 denotes p65
T28305 35998-36001 Q04206 denotes p65
T28306 36052-36055 P04608 denotes Tat
T28307 36052-36055 P04605 denotes Tat
T28308 36052-36055 P04610 denotes Tat
T28309 36052-36055 Q8UMQ1 denotes Tat
T28310 36168-36171 P04608 denotes Tat
T28311 36168-36171 P04610 denotes Tat
T28312 36168-36171 Q8UMQ1 denotes Tat
T28313 36168-36171 P04605 denotes Tat
T28314 36196-36199 P04591 denotes p24
T28315 36196-36199 P12497 denotes p24
T28316 36196-36199 P03366 denotes p24
T28317 36196-36199 P04585 denotes p24
T28318 36282-36285 P04605 denotes Tat
T28319 36282-36285 Q8UMQ1 denotes Tat
T28320 36282-36285 P04610 denotes Tat
T28321 36282-36285 P04608 denotes Tat
T28322 36327-36330 P03366 denotes p24
T28323 36327-36330 P12497 denotes p24
T28324 36327-36330 P04591 denotes p24
T28325 36327-36330 P04585 denotes p24
T28326 36374-36377 Q04206 denotes p65
T28327 36374-36377 P21579 denotes p65
T28328 36948-36951 Q8UMQ1 denotes Tat
T28329 36948-36951 P04610 denotes Tat
T28330 36948-36951 P04608 denotes Tat
T28331 36948-36951 P04605 denotes Tat
T28332 37207-37210 Q04206 denotes p65
T28333 37207-37210 P21579 denotes p65
T28334 37302-37305 P04605 denotes Tat
T28335 37302-37305 P04608 denotes Tat
T28336 37302-37305 Q8UMQ1 denotes Tat
T28337 37302-37305 P04610 denotes Tat
T28338 37313-37316 Q04206 denotes p65
T28339 37313-37316 P21579 denotes p65
T28340 37430-37433 Q8UMQ1 denotes Tat
T28341 37430-37433 P04610 denotes Tat
T28342 37430-37433 P04605 denotes Tat
T28343 37430-37433 P04608 denotes Tat
T28344 37528-37534 P10147 denotes MIP-1α
T28345 37623-37626 P04608 denotes Tat
T28346 37623-37626 P04610 denotes Tat
T28347 37623-37626 P04605 denotes Tat
T28348 37623-37626 Q8UMQ1 denotes Tat
T28349 37742-37745 P04608 denotes Tat
T28350 37742-37745 P04610 denotes Tat
T28351 37742-37745 Q8UMQ1 denotes Tat
T28352 37742-37745 P04605 denotes Tat
T28353 37842-37845 P21579 denotes p65
T28354 37842-37845 Q04206 denotes p65
T28355 37922-37928 P10147 denotes MIP-1α
T28356 37933-37938 P04406 denotes GAPDH
T29178 43641-43647 P10147 denotes MIP-1α
T29179 43684-43687 P04608 denotes Tat
T29180 43684-43687 P04605 denotes Tat
T29181 43684-43687 P04610 denotes Tat
T29182 43684-43687 Q8UMQ1 denotes Tat
T29183 43707-43710 P04610 denotes Tat
T29184 43707-43710 P04608 denotes Tat
T29185 43707-43710 Q8UMQ1 denotes Tat
T29186 43707-43710 P04605 denotes Tat
T29187 43753-43759 P10147 denotes MIP-1α
T29188 43878-43881 P04605 denotes Tat
T29189 43878-43881 P04608 denotes Tat
T29190 43878-43881 Q8UMQ1 denotes Tat
T29191 43878-43881 P04610 denotes Tat
T29192 43896-43902 P10147 denotes MIP-1α
T29193 44004-44007 Q04206 denotes p65
T29194 44004-44007 P21579 denotes p65
T6125 8964-8967 P04605 denotes Tat
T6126 8964-8967 P04608 denotes Tat
T6127 8964-8967 P04610 denotes Tat
T6128 8964-8967 Q8UMQ1 denotes Tat
T6129 9001-9004 P04578 denotes Env
T6130 9126-9129 P03366 denotes p24
T6131 9126-9129 P04591 denotes p24
T6132 9126-9129 P04585 denotes p24
T6133 9126-9129 P12497 denotes p24
T6134 9232-9235 P04578 denotes Env
T6135 9267-9270 P04591 denotes p24
T6136 9267-9270 P04585 denotes p24
T6137 9267-9270 P12497 denotes p24
T6138 9267-9270 P03366 denotes p24
T27576 31514-31517 Q04206 denotes p65
T27577 31514-31517 P21579 denotes p65
T27578 31606-31609 P04610 denotes Tat
T27579 31606-31609 P04608 denotes Tat
T27580 31606-31609 P04605 denotes Tat
T27581 31606-31609 Q8UMQ1 denotes Tat
T27582 31619-31622 Q8UMQ1 denotes Tat
T27583 31619-31622 P04610 denotes Tat
T27584 31619-31622 P04608 denotes Tat
T27585 31619-31622 P04605 denotes Tat
T27586 31644-31647 P04610 denotes Tat
T27587 31644-31647 P04605 denotes Tat
T27588 31644-31647 P04608 denotes Tat
T27589 31644-31647 Q8UMQ1 denotes Tat
T27590 31686-31689 P21579 denotes p65
T27591 31686-31689 Q04206 denotes p65
T27592 31754-31757 P04608 denotes Tat
T27593 31754-31757 P04610 denotes Tat
T27594 31754-31757 P04605 denotes Tat
T27595 31754-31757 Q8UMQ1 denotes Tat
T27596 31776-31779 P21579 denotes p65
T27597 31776-31779 Q04206 denotes p65
T27598 31929-31935 P10147 denotes MIP-1α
T27599 31941-31945 P09919 denotes CSF3