PMC:3320587 / 47263-47819 JSONTXT

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is activated after MTb engagement of PRRs [20], [66]. Multiple studies of HIV-1 activation have shown that initial recruitment of the NF-κB p50/p65 heterodimer to the HIV-1 proviral enhancer region is crucial for HIV gene transcription (reviewed in [67], [68]). Upon interaction with the viral LTR, NF-κB rapidly induces hyperacetylation of histones associated with nucleosome 1 (nuc-1) at the HIV-1 transcription start site, resulting in recruitment of the pTEFb complex, which is required for RNA pol II processivity ([69], reviewed in [68], [70])."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T17343","span":{"begin":150,"end":153},"obj":"Protein"},{"id":"T17342","span":{"begin":146,"end":149},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"NF-κB is activated after MTb engagement of PRRs [20], [66]. Multiple studies of HIV-1 activation have shown that initial recruitment of the NF-κB p50/p65 heterodimer to the HIV-1 proviral enhancer region is crucial for HIV gene transcription (reviewed in [67], [68]). Upon interaction with the viral LTR, NF-κB rapidly induces hyperacetylation of histones associated with nucleosome 1 (nuc-1) at the HIV-1 transcription start site, resulting in recruitment of the pTEFb complex, which is required for RNA pol II processivity ([69], reviewed in [68], [70])."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T18854","span":{"begin":150,"end":153},"obj":"http://www.uniprot.org/uniprot/P21579"},{"id":"T18852","span":{"begin":150,"end":153},"obj":"http://www.uniprot.org/uniprot/Q04206"},{"id":"T18850","span":{"begin":146,"end":149},"obj":"http://www.uniprot.org/uniprot/P19838"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"NF-κB is activated after MTb engagement of PRRs [20], [66]. Multiple studies of HIV-1 activation have shown that initial recruitment of the NF-κB p50/p65 heterodimer to the HIV-1 proviral enhancer region is crucial for HIV gene transcription (reviewed in [67], [68]). Upon interaction with the viral LTR, NF-κB rapidly induces hyperacetylation of histones associated with nucleosome 1 (nuc-1) at the HIV-1 transcription start site, resulting in recruitment of the pTEFb complex, which is required for RNA pol II processivity ([69], reviewed in [68], [70])."}

{"project":"GO-BP","denotations":[{"id":"T17420","span":{"begin":0,"end":18},"obj":"http://purl.obolibrary.org/obo/GO_0051092"},{"id":"T17378","span":{"begin":406,"end":419},"obj":"http://purl.obolibrary.org/obo/GO_0006351"},{"id":"T17377","span":{"begin":228,"end":241},"obj":"http://purl.obolibrary.org/obo/GO_0006351"}],"text":"NF-κB is activated after MTb engagement of PRRs [20], [66]. Multiple studies of HIV-1 activation have shown that initial recruitment of the NF-κB p50/p65 heterodimer to the HIV-1 proviral enhancer region is crucial for HIV gene transcription (reviewed in [67], [68]). Upon interaction with the viral LTR, NF-κB rapidly induces hyperacetylation of histones associated with nucleosome 1 (nuc-1) at the HIV-1 transcription start site, resulting in recruitment of the pTEFb complex, which is required for RNA pol II processivity ([69], reviewed in [68], [70])."}

{"project":"GO-CC","denotations":[{"id":"T17462","span":{"begin":372,"end":382},"obj":"http://purl.obolibrary.org/obo/GO_0000786"}],"text":"NF-κB is activated after MTb engagement of PRRs [20], [66]. Multiple studies of HIV-1 activation have shown that initial recruitment of the NF-κB p50/p65 heterodimer to the HIV-1 proviral enhancer region is crucial for HIV gene transcription (reviewed in [67], [68]). Upon interaction with the viral LTR, NF-κB rapidly induces hyperacetylation of histones associated with nucleosome 1 (nuc-1) at the HIV-1 transcription start site, resulting in recruitment of the pTEFb complex, which is required for RNA pol II processivity ([69], reviewed in [68], [70])."}

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