PMC:3320587 / 41009-41911
Annnotations
pmc-enju-pas
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begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
bionlp-st-ge-2016-test-proteins
{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T14913","span":{"begin":868,"end":873},"obj":"Protein"},{"id":"T14912","span":{"begin":689,"end":694},"obj":"Protein"},{"id":"T14911","span":{"begin":427,"end":432},"obj":"Protein"},{"id":"T14910","span":{"begin":383,"end":387},"obj":"Protein"},{"id":"T14909","span":{"begin":325,"end":330},"obj":"Protein"},{"id":"T14908","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T14907","span":{"begin":234,"end":239},"obj":"Protein"},{"id":"T14906","span":{"begin":56,"end":61},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
bionlp-st-ge-2016-uniprot
{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T15610","span":{"begin":868,"end":873},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T15609","span":{"begin":689,"end":694},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T15608","span":{"begin":427,"end":432},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T15607","span":{"begin":325,"end":330},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T15606","span":{"begin":234,"end":239},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T15605","span":{"begin":56,"end":61},"obj":"http://www.uniprot.org/uniprot/O94916"},{"id":"T15633","span":{"begin":383,"end":387},"obj":"http://www.uniprot.org/uniprot/O60603"},{"id":"T15632","span":{"begin":298,"end":302},"obj":"http://www.uniprot.org/uniprot/O60603"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
GO-BP
{"project":"GO-BP","denotations":[{"id":"T14972","span":{"begin":25,"end":33},"obj":"http://purl.obolibrary.org/obo/GO_0007349"},{"id":"T14969","span":{"begin":154,"end":163},"obj":"http://purl.obolibrary.org/obo/GO_0023052"},{"id":"T14961","span":{"begin":874,"end":889},"obj":"http://purl.obolibrary.org/obo/GO_0010467"},{"id":"T14960","span":{"begin":240,"end":255},"obj":"http://purl.obolibrary.org/obo/GO_0010467"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
GO-CC
{"project":"GO-CC","denotations":[{"id":"T14978","span":{"begin":625,"end":630},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14977","span":{"begin":541,"end":546},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14976","span":{"begin":496,"end":501},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T14975","span":{"begin":355,"end":360},"obj":"http://purl.obolibrary.org/obo/GO_0005623"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
sentences
{"project":"sentences","denotations":[{"id":"T14771","span":{"begin":657,"end":902},"obj":"Sentence"},{"id":"T14770","span":{"begin":560,"end":656},"obj":"Sentence"},{"id":"T14769","span":{"begin":344,"end":559},"obj":"Sentence"},{"id":"T14768","span":{"begin":257,"end":343},"obj":"Sentence"},{"id":"T14767","span":{"begin":0,"end":256},"obj":"Sentence"},{"id":"T240","span":{"begin":0,"end":256},"obj":"Sentence"},{"id":"T241","span":{"begin":257,"end":343},"obj":"Sentence"},{"id":"T242","span":{"begin":344,"end":559},"obj":"Sentence"},{"id":"T243","span":{"begin":560,"end":656},"obj":"Sentence"},{"id":"T244","span":{"begin":657,"end":902},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
simple1
{"project":"simple1","denotations":[{"id":"T14993","span":{"begin":868,"end":873},"obj":"Protein"},{"id":"T14992","span":{"begin":689,"end":694},"obj":"Protein"},{"id":"T14991","span":{"begin":427,"end":432},"obj":"Protein"},{"id":"T14990","span":{"begin":383,"end":387},"obj":"Protein"},{"id":"T14989","span":{"begin":325,"end":330},"obj":"Protein"},{"id":"T14988","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T14987","span":{"begin":234,"end":239},"obj":"Protein"},{"id":"T14986","span":{"begin":56,"end":61},"obj":"Protein"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
BioNLP16_DUT
{"project":"BioNLP16_DUT","denotations":[{"id":"T16752","span":{"begin":879,"end":889},"obj":"Gene_expression"},{"id":"T16751","span":{"begin":831,"end":841},"obj":"Positive_regulation"},{"id":"T16750","span":{"begin":700,"end":706},"obj":"Transcription"},{"id":"T16749","span":{"begin":858,"end":864},"obj":"Regulation"},{"id":"T16748","span":{"begin":680,"end":688},"obj":"Positive_regulation"},{"id":"T16747","span":{"begin":438,"end":444},"obj":"Transcription"},{"id":"T16746","span":{"begin":464,"end":473},"obj":"Positive_regulation"},{"id":"T16745","span":{"begin":315,"end":324},"obj":"Positive_regulation"},{"id":"T16744","span":{"begin":336,"end":342},"obj":"Transcription"},{"id":"T16743","span":{"begin":283,"end":294},"obj":"Positive_regulation"},{"id":"T16742","span":{"begin":303,"end":311},"obj":"Binding"},{"id":"T16741","span":{"begin":245,"end":255},"obj":"Gene_expression"},{"id":"T16693","span":{"begin":689,"end":694},"obj":"Protein"},{"id":"T16692","span":{"begin":868,"end":873},"obj":"Protein"},{"id":"T16691","span":{"begin":427,"end":432},"obj":"Protein"},{"id":"T16690","span":{"begin":383,"end":387},"obj":"Protein"},{"id":"T16689","span":{"begin":325,"end":330},"obj":"Protein"},{"id":"T16688","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T16687","span":{"begin":234,"end":239},"obj":"Protein"},{"id":"T16686","span":{"begin":56,"end":61},"obj":"Protein"}],"relations":[{"id":"R12364","pred":"themeOf","subj":"T16687","obj":"T16741"},{"id":"R12365","pred":"themeOf","subj":"T16688","obj":"T16742"},{"id":"R12366","pred":"themeOf","subj":"T16689","obj":"T16745"},{"id":"R12367","pred":"themeOf","subj":"T16689","obj":"T16744"},{"id":"R12368","pred":"themeOf","subj":"T16691","obj":"T16747"},{"id":"R12369","pred":"themeOf","subj":"T16691","obj":"T16746"},{"id":"R12370","pred":"themeOf","subj":"T16692","obj":"T16752"},{"id":"R12371","pred":"themeOf","subj":"T16693","obj":"T16748"},{"id":"R12372","pred":"themeOf","subj":"T16693","obj":"T16750"},{"id":"R12415","pred":"themeOf","subj":"T16745","obj":"T16743"},{"id":"R12416","pred":"themeOf","subj":"T16749","obj":"T16751"},{"id":"R12417","pred":"themeOf","subj":"T16752","obj":"T16749"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
BioNLP16_Messiy
{"project":"BioNLP16_Messiy","denotations":[{"id":"T15830","span":{"begin":858,"end":864},"obj":"Regulation"},{"id":"T15829","span":{"begin":680,"end":688},"obj":"Positive_regulation"},{"id":"T15828","span":{"begin":879,"end":889},"obj":"Gene_expression"},{"id":"T15827","span":{"begin":464,"end":473},"obj":"Positive_regulation"},{"id":"T15826","span":{"begin":315,"end":324},"obj":"Positive_regulation"},{"id":"T15825","span":{"begin":303,"end":311},"obj":"Binding"},{"id":"T15824","span":{"begin":245,"end":255},"obj":"Gene_expression"},{"id":"T15776","span":{"begin":689,"end":694},"obj":"Protein"},{"id":"T15775","span":{"begin":868,"end":873},"obj":"Protein"},{"id":"T15774","span":{"begin":427,"end":432},"obj":"Protein"},{"id":"T15773","span":{"begin":383,"end":387},"obj":"Protein"},{"id":"T15772","span":{"begin":325,"end":330},"obj":"Protein"},{"id":"T15771","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T15770","span":{"begin":234,"end":239},"obj":"Protein"},{"id":"T15769","span":{"begin":56,"end":61},"obj":"Protein"}],"relations":[{"id":"R11604","pred":"themeOf","subj":"T15770","obj":"T15824"},{"id":"R11605","pred":"themeOf","subj":"T15771","obj":"T15825"},{"id":"R11606","pred":"themeOf","subj":"T15772","obj":"T15826"},{"id":"R11607","pred":"themeOf","subj":"T15774","obj":"T15827"},{"id":"R11608","pred":"themeOf","subj":"T15775","obj":"T15828"},{"id":"R11609","pred":"themeOf","subj":"T15776","obj":"T15829"},{"id":"R11646","pred":"themeOf","subj":"T15828","obj":"T15830"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
DLUT931
{"project":"DLUT931","denotations":[{"id":"T15716","span":{"begin":464,"end":473},"obj":"Positive_regulation"},{"id":"T15715","span":{"begin":438,"end":444},"obj":"Transcription"},{"id":"T15714","span":{"begin":315,"end":324},"obj":"Positive_regulation"},{"id":"T15713","span":{"begin":283,"end":294},"obj":"Positive_regulation"},{"id":"T15712","span":{"begin":336,"end":342},"obj":"Transcription"},{"id":"T15711","span":{"begin":303,"end":311},"obj":"Binding"},{"id":"T15710","span":{"begin":202,"end":210},"obj":"Positive_regulation"},{"id":"T15709","span":{"begin":245,"end":255},"obj":"Gene_expression"},{"id":"T15661","span":{"begin":689,"end":694},"obj":"Protein"},{"id":"T15660","span":{"begin":868,"end":873},"obj":"Protein"},{"id":"T15659","span":{"begin":427,"end":432},"obj":"Protein"},{"id":"T15658","span":{"begin":383,"end":387},"obj":"Protein"},{"id":"T15657","span":{"begin":325,"end":330},"obj":"Protein"},{"id":"T15656","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T15655","span":{"begin":234,"end":239},"obj":"Protein"},{"id":"T15654","span":{"begin":56,"end":61},"obj":"Protein"},{"id":"T15720","span":{"begin":858,"end":864},"obj":"Regulation"},{"id":"T15719","span":{"begin":680,"end":688},"obj":"Positive_regulation"},{"id":"T15718","span":{"begin":879,"end":889},"obj":"Gene_expression"},{"id":"T15717","span":{"begin":700,"end":706},"obj":"Transcription"}],"relations":[{"id":"R11503","pred":"themeOf","subj":"T15656","obj":"T15711"},{"id":"R11504","pred":"themeOf","subj":"T15657","obj":"T15712"},{"id":"R11505","pred":"themeOf","subj":"T15659","obj":"T15715"},{"id":"R11506","pred":"themeOf","subj":"T15660","obj":"T15718"},{"id":"R11507","pred":"themeOf","subj":"T15661","obj":"T15717"},{"id":"R11552","pred":"themeOf","subj":"T15709","obj":"T15710"},{"id":"R11553","pred":"themeOf","subj":"T15711","obj":"T15713"},{"id":"R11554","pred":"themeOf","subj":"T15712","obj":"T15714"},{"id":"R11555","pred":"themeOf","subj":"T15714","obj":"T15713"},{"id":"R11556","pred":"themeOf","subj":"T15715","obj":"T15716"},{"id":"R11557","pred":"themeOf","subj":"T15717","obj":"T15719"},{"id":"R11558","pred":"themeOf","subj":"T15718","obj":"T15720"},{"id":"R11502","pred":"themeOf","subj":"T15655","obj":"T15709"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
bionlp-st-ge-2016-test-ihmc
{"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T16915","span":{"begin":865,"end":901},"obj":"Gene_expression"},{"id":"T16914","span":{"begin":764,"end":829},"obj":"Positive_regulation"},{"id":"T16912","span":{"begin":666,"end":679},"obj":"Regulation"},{"id":"T16904","span":{"begin":231,"end":255},"obj":"Gene_expression"},{"id":"T16903","span":{"begin":215,"end":255},"obj":"Positive_regulation"},{"id":"T16902","span":{"begin":809,"end":829},"obj":"Regulation"},{"id":"T16900","span":{"begin":514,"end":540},"obj":"Positive_regulation"},{"id":"T16889","span":{"begin":325,"end":330},"obj":"Protein"},{"id":"T16883","span":{"begin":427,"end":432},"obj":"Protein"},{"id":"T16882","span":{"begin":666,"end":669},"obj":"Protein"},{"id":"T16879","span":{"begin":325,"end":342},"obj":"Protein"},{"id":"T16874","span":{"begin":73,"end":84},"obj":"Protein"},{"id":"T16873","span":{"begin":21,"end":102},"obj":"Protein"},{"id":"T16860","span":{"begin":234,"end":239},"obj":"Protein"},{"id":"T16859","span":{"begin":397,"end":404},"obj":"Entity"},{"id":"T16858","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T16847","span":{"begin":164,"end":173},"obj":"Entity"},{"id":"T16843","span":{"begin":689,"end":706},"obj":"Protein"},{"id":"T16838","span":{"begin":695,"end":699},"obj":"Protein"},{"id":"T16835","span":{"begin":769,"end":784},"obj":"Protein"},{"id":"T16831","span":{"begin":477,"end":480},"obj":"Protein"},{"id":"T16825","span":{"begin":868,"end":873},"obj":"Protein"},{"id":"T16819","span":{"begin":215,"end":218},"obj":"Protein"},{"id":"T16816","span":{"begin":816,"end":819},"obj":"Protein"},{"id":"T16811","span":{"begin":379,"end":396},"obj":"Protein"},{"id":"T16795","span":{"begin":541,"end":558},"obj":"Entity"}],"relations":[{"id":"R12433","pred":"themeOf","subj":"T16816","obj":"T16902"},{"id":"R12435","pred":"causeOf","subj":"T16819","obj":"T16903"},{"id":"R12437","pred":"themeOf","subj":"T16825","obj":"T16915"},{"id":"R12441","pred":"themeOf","subj":"T16835","obj":"T16914"},{"id":"R12449","pred":"themeOf","subj":"T16860","obj":"T16904"},{"id":"R12455","pred":"themeOf","subj":"T16882","obj":"T16912"},{"id":"R12460","pred":"themeOf","subj":"T16904","obj":"T16903"}],"attributes":[{"id":"M24","pred":"Speculation","subj":"T16914","obj":"true"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
bionlp-st-ge-2016-spacy-parsed
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begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
bionlp-st-ge-2016-test-tees
{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T15962","span":{"begin":831,"end":841},"obj":"Positive_regulation"},{"id":"T15961","span":{"begin":858,"end":864},"obj":"Regulation"},{"id":"T15960","span":{"begin":879,"end":889},"obj":"Gene_expression"},{"id":"T15959","span":{"begin":680,"end":688},"obj":"Positive_regulation"},{"id":"T15958","span":{"begin":868,"end":878},"obj":"Protein"},{"id":"T15957","span":{"begin":689,"end":699},"obj":"Protein"},{"id":"T15956","span":{"begin":464,"end":473},"obj":"Positive_regulation"},{"id":"T15955","span":{"begin":427,"end":437},"obj":"Protein"},{"id":"T15954","span":{"begin":315,"end":324},"obj":"Positive_regulation"},{"id":"T15953","span":{"begin":303,"end":311},"obj":"Binding"},{"id":"T15952","span":{"begin":325,"end":335},"obj":"Protein"},{"id":"T15951","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T15950","span":{"begin":245,"end":255},"obj":"Gene_expression"},{"id":"T15949","span":{"begin":234,"end":244},"obj":"Protein"},{"id":"T15948","span":{"begin":181,"end":184},"obj":"Protein"},{"id":"T15947","span":{"begin":56,"end":61},"obj":"Protein"}],"relations":[{"id":"R11698","pred":"themeOf","subj":"T15949","obj":"T15950"},{"id":"R11699","pred":"themeOf","subj":"T15951","obj":"T15953"},{"id":"R11700","pred":"themeOf","subj":"T15952","obj":"T15954"},{"id":"R11701","pred":"themeOf","subj":"T15955","obj":"T15956"},{"id":"R11702","pred":"themeOf","subj":"T15957","obj":"T15959"},{"id":"R11703","pred":"themeOf","subj":"T15958","obj":"T15960"},{"id":"R11704","pred":"themeOf","subj":"T15960","obj":"T15961"},{"id":"R11705","pred":"themeOf","subj":"T15961","obj":"T15962"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
testone
{"project":"testone","denotations":[{"id":"T14600","span":{"begin":680,"end":688},"obj":"Positive_regulation"},{"id":"T14599","span":{"begin":303,"end":311},"obj":"Binding"},{"id":"T14598","span":{"begin":283,"end":294},"obj":"Positive_regulation"},{"id":"T14597","span":{"begin":245,"end":255},"obj":"Gene_expression"},{"id":"T14550","span":{"begin":868,"end":873},"obj":"Protein"},{"id":"T14549","span":{"begin":689,"end":694},"obj":"Protein"},{"id":"T14548","span":{"begin":427,"end":432},"obj":"Protein"},{"id":"T14547","span":{"begin":383,"end":387},"obj":"Protein"},{"id":"T14546","span":{"begin":325,"end":330},"obj":"Protein"},{"id":"T14545","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T14544","span":{"begin":234,"end":239},"obj":"Protein"},{"id":"T14543","span":{"begin":56,"end":61},"obj":"Protein"}],"relations":[{"id":"R10812","pred":"themeOf","subj":"T14544","obj":"T14597"},{"id":"R10813","pred":"themeOf","subj":"T14545","obj":"T14599"},{"id":"R10814","pred":"themeOf","subj":"T14549","obj":"T14600"},{"id":"R10840","pred":"themeOf","subj":"T14599","obj":"T14598"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}
test3
{"project":"test3","denotations":[{"id":"T14696","span":{"begin":868,"end":873},"obj":"Protein"},{"id":"T14695","span":{"begin":689,"end":694},"obj":"Protein"},{"id":"T14694","span":{"begin":464,"end":473},"obj":"Positive_regulation"},{"id":"T14693","span":{"begin":427,"end":432},"obj":"Protein"},{"id":"T14692","span":{"begin":383,"end":387},"obj":"Protein"},{"id":"T14691","span":{"begin":325,"end":330},"obj":"Protein"},{"id":"T14690","span":{"begin":303,"end":311},"obj":"Binding"},{"id":"T14689","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T14688","span":{"begin":234,"end":239},"obj":"Protein"},{"id":"T14687","span":{"begin":56,"end":61},"obj":"Protein"},{"id":"T14639","span":{"begin":868,"end":873},"obj":"Protein"},{"id":"T14638","span":{"begin":689,"end":694},"obj":"Protein"},{"id":"T14637","span":{"begin":427,"end":432},"obj":"Protein"},{"id":"T14636","span":{"begin":383,"end":387},"obj":"Protein"},{"id":"T14635","span":{"begin":325,"end":330},"obj":"Protein"},{"id":"T14634","span":{"begin":298,"end":302},"obj":"Protein"},{"id":"T14633","span":{"begin":234,"end":239},"obj":"Protein"},{"id":"T14632","span":{"begin":56,"end":61},"obj":"Protein"}],"relations":[{"id":"R10853","pred":"themeOf","subj":"T14689","obj":"T14690"},{"id":"R10854","pred":"themeOf","subj":"T14693","obj":"T14694"}],"text":"To begin to decipher the cellular mechanisms underlying NFAT5-dependent, MTb-induced HIV-1 replication, we next investigated the requirement for specific signaling molecules in the TLR pathway that are required for MTb stimulation of NFAT5 gene expression. We began by examining the requirement of TLR2 ligation in enhancing NFAT5 mRNA levels. When THP-1 cells were treated with the TLR2-specific agonist Pam3Cys for 16 hours, NFAT5 mRNA levels were significantly increased in Pam3Cys-stimulated cells as compared to mock-stimulated control cells (Figure 7A). As a positive control for this experiment we also infected THP-1 cells with CDC1551 (Figure 7A). Notably, MTb infection enhanced NFAT5 mRNA levels to a greater extent than Pam3Cys stimulation, suggesting that additional PRRs may be triggered during actual MTb infection, augmenting its stimulatory effect on NFAT5 gene expression (Figure 7A)."}