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Figure 5 Disruption of NF-κB or NFAT5 sites in the LTR inhibits MTb-induced HIV-1 replication in MDM.\nMDM from four normal donors were infected with 1000 TCID50 of HIV-1Lai/Bal-env–WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut, and were either (A) left infected with virus alone or (B) co-infected with MTb CDC1551 (1∶1 MDM∶bacilli). 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{"project":"sentences","denotations":[{"id":"T25858","span":{"begin":548,"end":746},"obj":"Sentence"},{"id":"T25857","span":{"begin":453,"end":547},"obj":"Sentence"},{"id":"T25856","span":{"begin":137,"end":452},"obj":"Sentence"},{"id":"T25855","span":{"begin":44,"end":136},"obj":"Sentence"},{"id":"T206","span":{"begin":0,"end":136},"obj":"Sentence"},{"id":"T207","span":{"begin":137,"end":452},"obj":"Sentence"},{"id":"T208","span":{"begin":453,"end":547},"obj":"Sentence"},{"id":"T209","span":{"begin":548,"end":746},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"10.1371/journal.ppat.1002620.g005 Figure 5 Disruption of NF-κB or NFAT5 sites in the LTR inhibits MTb-induced HIV-1 replication in MDM.\nMDM from four normal donors were infected with 1000 TCID50 of HIV-1Lai/Bal-env–WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut, and were either (A) left infected with virus alone or (B) co-infected with MTb CDC1551 (1∶1 MDM∶bacilli). Viral p24 levels in the culture supernatants were measured at days 4, 7 and 12 post-infection. Presentation of viral p24 levels at day 12 in cultures infected with (C) HIV-1 alone or (D) co-infected with MTb are shown as histograms. (*, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-env–WT)."}

{"project":"simple1","denotations":[{"id":"T25890","span":{"begin":738,"end":741},"obj":"Protein"},{"id":"T25889","span":{"begin":570,"end":573},"obj":"Protein"},{"id":"T25888","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T25887","span":{"begin":335,"end":338},"obj":"Protein"},{"id":"T25886","span":{"begin":302,"end":305},"obj":"Protein"},{"id":"T25885","span":{"begin":274,"end":277},"obj":"Protein"},{"id":"T25884","span":{"begin":247,"end":250},"obj":"Protein"},{"id":"T25883","span":{"begin":212,"end":215},"obj":"Protein"}],"text":"10.1371/journal.ppat.1002620.g005 Figure 5 Disruption of NF-κB or NFAT5 sites in the LTR inhibits MTb-induced HIV-1 replication in MDM.\nMDM from four normal donors were infected with 1000 TCID50 of HIV-1Lai/Bal-env–WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut, and were either (A) left infected with virus alone or (B) co-infected with MTb CDC1551 (1∶1 MDM∶bacilli). Viral p24 levels in the culture supernatants were measured at days 4, 7 and 12 post-infection. Presentation of viral p24 levels at day 12 in cultures infected with (C) HIV-1 alone or (D) co-infected with MTb are shown as histograms. (*, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-env–WT)."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T26262","span":{"begin":738,"end":741},"obj":"Protein"},{"id":"T26261","span":{"begin":570,"end":573},"obj":"Protein"},{"id":"T26260","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T26259","span":{"begin":335,"end":338},"obj":"Protein"},{"id":"T26258","span":{"begin":302,"end":305},"obj":"Protein"},{"id":"T26257","span":{"begin":274,"end":277},"obj":"Protein"},{"id":"T26256","span":{"begin":247,"end":250},"obj":"Protein"},{"id":"T26255","span":{"begin":212,"end":215},"obj":"Protein"}],"text":"10.1371/journal.ppat.1002620.g005 Figure 5 Disruption of NF-κB or NFAT5 sites in the LTR inhibits MTb-induced HIV-1 replication in MDM.\nMDM from four normal donors were infected with 1000 TCID50 of HIV-1Lai/Bal-env–WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut, and were either (A) left infected with virus alone or (B) co-infected with MTb CDC1551 (1∶1 MDM∶bacilli). Viral p24 levels in the culture supernatants were measured at days 4, 7 and 12 post-infection. Presentation of viral p24 levels at day 12 in cultures infected with (C) HIV-1 alone or (D) co-infected with MTb are shown as histograms. (*, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-env–WT)."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T26057","span":{"begin":738,"end":741},"obj":"Protein"},{"id":"T26056","span":{"begin":570,"end":573},"obj":"Protein"},{"id":"T26055","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T26054","span":{"begin":335,"end":338},"obj":"Protein"},{"id":"T26053","span":{"begin":302,"end":305},"obj":"Protein"},{"id":"T26052","span":{"begin":274,"end":277},"obj":"Protein"},{"id":"T26051","span":{"begin":247,"end":250},"obj":"Protein"},{"id":"T26050","span":{"begin":212,"end":215},"obj":"Protein"}],"text":"10.1371/journal.ppat.1002620.g005 Figure 5 Disruption of NF-κB or NFAT5 sites in the LTR inhibits MTb-induced HIV-1 replication in MDM.\nMDM from four normal donors were infected with 1000 TCID50 of HIV-1Lai/Bal-env–WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut, and were either (A) left infected with virus alone or (B) co-infected with MTb CDC1551 (1∶1 MDM∶bacilli). Viral p24 levels in the culture supernatants were measured at days 4, 7 and 12 post-infection. Presentation of viral p24 levels at day 12 in cultures infected with (C) HIV-1 alone or (D) co-infected with MTb are shown as histograms. (*, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-env–WT)."}

{"project":"DLUT931","denotations":[{"id":"T26049","span":{"begin":738,"end":741},"obj":"Protein"},{"id":"T26048","span":{"begin":570,"end":573},"obj":"Protein"},{"id":"T26047","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T26046","span":{"begin":335,"end":338},"obj":"Protein"},{"id":"T26045","span":{"begin":302,"end":305},"obj":"Protein"},{"id":"T26044","span":{"begin":274,"end":277},"obj":"Protein"},{"id":"T26043","span":{"begin":247,"end":250},"obj":"Protein"},{"id":"T26042","span":{"begin":212,"end":215},"obj":"Protein"}],"text":"10.1371/journal.ppat.1002620.g005 Figure 5 Disruption of NF-κB or NFAT5 sites in the LTR inhibits MTb-induced HIV-1 replication in MDM.\nMDM from four normal donors were infected with 1000 TCID50 of HIV-1Lai/Bal-env–WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut, and were either (A) left infected with virus alone or (B) co-infected with MTb CDC1551 (1∶1 MDM∶bacilli). Viral p24 levels in the culture supernatants were measured at days 4, 7 and 12 post-infection. Presentation of viral p24 levels at day 12 in cultures infected with (C) HIV-1 alone or (D) co-infected with MTb are shown as histograms. (*, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-env–WT)."}

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Figure 5 Disruption of NF-κB or NFAT5 sites in the LTR inhibits MTb-induced HIV-1 replication in MDM.\nMDM from four normal donors were infected with 1000 TCID50 of HIV-1Lai/Bal-env–WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut, and were either (A) left infected with virus alone or (B) co-infected with MTb CDC1551 (1∶1 MDM∶bacilli). Viral p24 levels in the culture supernatants were measured at days 4, 7 and 12 post-infection. Presentation of viral p24 levels at day 12 in cultures infected with (C) HIV-1 alone or (D) co-infected with MTb are shown as histograms. (*, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-env–WT)."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T26079","span":{"begin":742,"end":744},"obj":"Protein"},{"id":"T26078","span":{"begin":738,"end":741},"obj":"Protein"},{"id":"T26077","span":{"begin":570,"end":573},"obj":"Protein"},{"id":"T26076","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T26075","span":{"begin":342,"end":345},"obj":"Protein"},{"id":"T26074","span":{"begin":339,"end":341},"obj":"Protein"},{"id":"T26073","span":{"begin":335,"end":338},"obj":"Protein"},{"id":"T26072","span":{"begin":314,"end":317},"obj":"Protein"},{"id":"T26071","span":{"begin":306,"end":313},"obj":"Protein"},{"id":"T26070","span":{"begin":302,"end":305},"obj":"Protein"},{"id":"T26069","span":{"begin":284,"end":287},"obj":"Protein"},{"id":"T26068","span":{"begin":278,"end":283},"obj":"Protein"},{"id":"T26067","span":{"begin":274,"end":277},"obj":"Protein"},{"id":"T26066","span":{"begin":256,"end":259},"obj":"Protein"},{"id":"T26065","span":{"begin":251,"end":255},"obj":"Protein"},{"id":"T26064","span":{"begin":247,"end":250},"obj":"Protein"},{"id":"T26063","span":{"begin":216,"end":218},"obj":"Protein"},{"id":"T26062","span":{"begin":212,"end":215},"obj":"Protein"},{"id":"T26061","span":{"begin":44,"end":54},"obj":"Binding"},{"id":"T26060","span":{"begin":44,"end":54},"obj":"Binding"},{"id":"T26059","span":{"begin":67,"end":78},"obj":"Protein"},{"id":"T26058","span":{"begin":58,"end":63},"obj":"Protein"}],"relations":[{"id":"R18972","pred":"themeOf","subj":"T26058","obj":"T26060"},{"id":"R18973","pred":"themeOf","subj":"T26059","obj":"T26061"}],"text":"10.1371/journal.ppat.1002620.g005 Figure 5 Disruption of NF-κB or NFAT5 sites in the LTR inhibits MTb-induced HIV-1 replication in MDM.\nMDM from four normal donors were infected with 1000 TCID50 of HIV-1Lai/Bal-env–WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut, and were either (A) left infected with virus alone or (B) co-infected with MTb CDC1551 (1∶1 MDM∶bacilli). Viral p24 levels in the culture supernatants were measured at days 4, 7 and 12 post-infection. Presentation of viral p24 levels at day 12 in cultures infected with (C) HIV-1 alone or (D) co-infected with MTb are shown as histograms. (*, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-env–WT)."}

{"project":"testone","denotations":[{"id":"T25838","span":{"begin":738,"end":741},"obj":"Protein"},{"id":"T25837","span":{"begin":570,"end":573},"obj":"Protein"},{"id":"T25836","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T25835","span":{"begin":335,"end":338},"obj":"Protein"},{"id":"T25834","span":{"begin":302,"end":305},"obj":"Protein"},{"id":"T25833","span":{"begin":274,"end":277},"obj":"Protein"},{"id":"T25832","span":{"begin":247,"end":250},"obj":"Protein"},{"id":"T25831","span":{"begin":212,"end":215},"obj":"Protein"}],"text":"10.1371/journal.ppat.1002620.g005 Figure 5 Disruption of NF-κB or NFAT5 sites in the LTR inhibits MTb-induced HIV-1 replication in MDM.\nMDM from four normal donors were infected with 1000 TCID50 of HIV-1Lai/Bal-env–WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut, and were either (A) left infected with virus alone or (B) co-infected with MTb CDC1551 (1∶1 MDM∶bacilli). Viral p24 levels in the culture supernatants were measured at days 4, 7 and 12 post-infection. Presentation of viral p24 levels at day 12 in cultures infected with (C) HIV-1 alone or (D) co-infected with MTb are shown as histograms. (*, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-env–WT)."}

{"project":"test3","denotations":[{"id":"T25854","span":{"begin":738,"end":741},"obj":"Protein"},{"id":"T25853","span":{"begin":570,"end":573},"obj":"Protein"},{"id":"T25852","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T25851","span":{"begin":335,"end":338},"obj":"Protein"},{"id":"T25850","span":{"begin":302,"end":305},"obj":"Protein"},{"id":"T25849","span":{"begin":274,"end":277},"obj":"Protein"},{"id":"T25848","span":{"begin":247,"end":250},"obj":"Protein"},{"id":"T25847","span":{"begin":212,"end":215},"obj":"Protein"},{"id":"T25846","span":{"begin":738,"end":741},"obj":"Protein"},{"id":"T25845","span":{"begin":570,"end":573},"obj":"Protein"},{"id":"T25844","span":{"begin":459,"end":462},"obj":"Protein"},{"id":"T25843","span":{"begin":335,"end":338},"obj":"Protein"},{"id":"T25842","span":{"begin":302,"end":305},"obj":"Protein"},{"id":"T25841","span":{"begin":274,"end":277},"obj":"Protein"},{"id":"T25840","span":{"begin":247,"end":250},"obj":"Protein"},{"id":"T25839","span":{"begin":212,"end":215},"obj":"Protein"}],"text":"10.1371/journal.ppat.1002620.g005 Figure 5 Disruption of NF-κB or NFAT5 sites in the LTR inhibits MTb-induced HIV-1 replication in MDM.\nMDM from four normal donors were infected with 1000 TCID50 of HIV-1Lai/Bal-env–WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut, and were either (A) left infected with virus alone or (B) co-infected with MTb CDC1551 (1∶1 MDM∶bacilli). Viral p24 levels in the culture supernatants were measured at days 4, 7 and 12 post-infection. Presentation of viral p24 levels at day 12 in cultures infected with (C) HIV-1 alone or (D) co-infected with MTb are shown as histograms. (*, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-env–WT)."}