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disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T25286","span":{"begin":236,"end":239},"obj":"Protein"},{"id":"T25292","span":{"begin":585,"end":588},"obj":"Protein"},{"id":"T25291","span":{"begin":474,"end":477},"obj":"Protein"},{"id":"T25290","span":{"begin":359,"end":362},"obj":"Protein"},{"id":"T25289","span":{"begin":326,"end":329},"obj":"Protein"},{"id":"T25288","span":{"begin":298,"end":301},"obj":"Protein"},{"id":"T25287","span":{"begin":271,"end":274},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T25498","span":{"begin":585,"end":588},"obj":"http://www.uniprot.org/uniprot/P03366"},{"id":"T25497","span":{"begin":474,"end":477},"obj":"http://www.uniprot.org/uniprot/P03366"},{"id":"T25496","span":{"begin":585,"end":588},"obj":"http://www.uniprot.org/uniprot/P04585"},{"id":"T25495","span":{"begin":474,"end":477},"obj":"http://www.uniprot.org/uniprot/P04585"},{"id":"T25494","span":{"begin":585,"end":588},"obj":"http://www.uniprot.org/uniprot/P12497"},{"id":"T25493","span":{"begin":474,"end":477},"obj":"http://www.uniprot.org/uniprot/P12497"},{"id":"T25492","span":{"begin":585,"end":588},"obj":"http://www.uniprot.org/uniprot/P04591"},{"id":"T25491","span":{"begin":474,"end":477},"obj":"http://www.uniprot.org/uniprot/P04591"},{"id":"T25490","span":{"begin":359,"end":362},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T25489","span":{"begin":326,"end":329},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T25488","span":{"begin":298,"end":301},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T25487","span":{"begin":271,"end":274},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T25486","span":{"begin":236,"end":239},"obj":"http://www.uniprot.org/uniprot/P04578"},{"id":"T25485","span":{"begin":36,"end":41},"obj":"http://www.uniprot.org/uniprot/O94916"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"GO-MF","denotations":[{"id":"T25294","span":{"begin":42,"end":49},"obj":"http://purl.obolibrary.org/obo/GO_0005488"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"sentences","denotations":[{"id":"T25275","span":{"begin":688,"end":914},"obj":"Sentence"},{"id":"T25274","span":{"begin":468,"end":687},"obj":"Sentence"},{"id":"T25273","span":{"begin":163,"end":467},"obj":"Sentence"},{"id":"T25272","span":{"begin":0,"end":162},"obj":"Sentence"},{"id":"T198","span":{"begin":0,"end":162},"obj":"Sentence"},{"id":"T199","span":{"begin":163,"end":467},"obj":"Sentence"},{"id":"T200","span":{"begin":468,"end":687},"obj":"Sentence"},{"id":"T201","span":{"begin":688,"end":914},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"simple1","denotations":[{"id":"T25310","span":{"begin":585,"end":588},"obj":"Protein"},{"id":"T25309","span":{"begin":474,"end":477},"obj":"Protein"},{"id":"T25308","span":{"begin":359,"end":362},"obj":"Protein"},{"id":"T25307","span":{"begin":326,"end":329},"obj":"Protein"},{"id":"T25306","span":{"begin":298,"end":301},"obj":"Protein"},{"id":"T25305","span":{"begin":271,"end":274},"obj":"Protein"},{"id":"T25304","span":{"begin":236,"end":239},"obj":"Protein"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"BioNLP16_DUT","denotations":[{"id":"T25789","span":{"begin":585,"end":588},"obj":"Protein"},{"id":"T25788","span":{"begin":474,"end":477},"obj":"Protein"},{"id":"T25787","span":{"begin":359,"end":362},"obj":"Protein"},{"id":"T25786","span":{"begin":326,"end":329},"obj":"Protein"},{"id":"T25785","span":{"begin":298,"end":301},"obj":"Protein"},{"id":"T25784","span":{"begin":271,"end":274},"obj":"Protein"},{"id":"T25783","span":{"begin":236,"end":239},"obj":"Protein"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"BioNLP16_Messiy","denotations":[{"id":"T25516","span":{"begin":585,"end":588},"obj":"Protein"},{"id":"T25515","span":{"begin":474,"end":477},"obj":"Protein"},{"id":"T25514","span":{"begin":359,"end":362},"obj":"Protein"},{"id":"T25513","span":{"begin":326,"end":329},"obj":"Protein"},{"id":"T25512","span":{"begin":298,"end":301},"obj":"Protein"},{"id":"T25511","span":{"begin":271,"end":274},"obj":"Protein"},{"id":"T25510","span":{"begin":236,"end":239},"obj":"Protein"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"DLUT931","denotations":[{"id":"T25506","span":{"begin":585,"end":588},"obj":"Protein"},{"id":"T25505","span":{"begin":474,"end":477},"obj":"Protein"},{"id":"T25504","span":{"begin":359,"end":362},"obj":"Protein"},{"id":"T25503","span":{"begin":326,"end":329},"obj":"Protein"},{"id":"T25502","span":{"begin":298,"end":301},"obj":"Protein"},{"id":"T25501","span":{"begin":271,"end":274},"obj":"Protein"},{"id":"T25500","span":{"begin":236,"end":239},"obj":"Protein"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

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PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"bionlp-st-ge-2016-test-tees","denotations":[{"id":"T25555","span":{"begin":911,"end":913},"obj":"Protein"},{"id":"T25554","span":{"begin":907,"end":910},"obj":"Protein"},{"id":"T25553","span":{"begin":585,"end":588},"obj":"Protein"},{"id":"T25552","span":{"begin":474,"end":477},"obj":"Protein"},{"id":"T25551","span":{"begin":366,"end":369},"obj":"Protein"},{"id":"T25550","span":{"begin":363,"end":365},"obj":"Protein"},{"id":"T25549","span":{"begin":359,"end":362},"obj":"Protein"},{"id":"T25548","span":{"begin":338,"end":341},"obj":"Protein"},{"id":"T25547","span":{"begin":330,"end":337},"obj":"Protein"},{"id":"T25546","span":{"begin":326,"end":329},"obj":"Protein"},{"id":"T25545","span":{"begin":308,"end":311},"obj":"Protein"},{"id":"T25544","span":{"begin":302,"end":307},"obj":"Protein"},{"id":"T25543","span":{"begin":298,"end":301},"obj":"Protein"},{"id":"T25542","span":{"begin":280,"end":283},"obj":"Protein"},{"id":"T25541","span":{"begin":275,"end":279},"obj":"Protein"},{"id":"T25540","span":{"begin":271,"end":274},"obj":"Protein"},{"id":"T25539","span":{"begin":240,"end":242},"obj":"Protein"},{"id":"T25538","span":{"begin":236,"end":239},"obj":"Protein"},{"id":"T25537","span":{"begin":9,"end":19},"obj":"Negative_regulation"},{"id":"T25536","span":{"begin":9,"end":19},"obj":"Negative_regulation"},{"id":"T25535","span":{"begin":9,"end":19},"obj":"Negative_regulation"},{"id":"T25534","span":{"begin":63,"end":82},"obj":"Protein"},{"id":"T25533","span":{"begin":36,"end":55},"obj":"Protein"},{"id":"T25532","span":{"begin":27,"end":32},"obj":"Protein"}],"relations":[{"id":"R18631","pred":"themeOf","subj":"T25532","obj":"T25535"},{"id":"R18632","pred":"themeOf","subj":"T25533","obj":"T25536"},{"id":"R18633","pred":"themeOf","subj":"T25534","obj":"T25537"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"testone","denotations":[{"id":"T25251","span":{"begin":474,"end":477},"obj":"Protein"},{"id":"T25250","span":{"begin":359,"end":362},"obj":"Protein"},{"id":"T25249","span":{"begin":326,"end":329},"obj":"Protein"},{"id":"T25248","span":{"begin":298,"end":301},"obj":"Protein"},{"id":"T25247","span":{"begin":271,"end":274},"obj":"Protein"},{"id":"T25246","span":{"begin":236,"end":239},"obj":"Protein"},{"id":"T25252","span":{"begin":585,"end":588},"obj":"Protein"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}

{"project":"test3","denotations":[{"id":"T25270","span":{"begin":585,"end":588},"obj":"Protein"},{"id":"T25269","span":{"begin":474,"end":477},"obj":"Protein"},{"id":"T25268","span":{"begin":359,"end":362},"obj":"Protein"},{"id":"T25267","span":{"begin":326,"end":329},"obj":"Protein"},{"id":"T25266","span":{"begin":298,"end":301},"obj":"Protein"},{"id":"T25265","span":{"begin":271,"end":274},"obj":"Protein"},{"id":"T25264","span":{"begin":236,"end":239},"obj":"Protein"},{"id":"T25261","span":{"begin":585,"end":588},"obj":"Protein"},{"id":"T25260","span":{"begin":474,"end":477},"obj":"Protein"},{"id":"T25259","span":{"begin":359,"end":362},"obj":"Protein"},{"id":"T25258","span":{"begin":326,"end":329},"obj":"Protein"},{"id":"T25257","span":{"begin":298,"end":301},"obj":"Protein"},{"id":"T25256","span":{"begin":271,"end":274},"obj":"Protein"},{"id":"T25255","span":{"begin":236,"end":239},"obj":"Protein"}],"text":"Specific disruption of the NF-κB or NFAT5 binding sites in the HIV-1 subtype B LTR inhibits R5-tropic virus replication in human PBMC after co-infection with MTb. PBMC from four normal donors were infected with 1000 TCID50 HIV-1Lai/Bal-env-WT or the mutants HIV-1Lai/Bal-env-κB I-Mut, HIV-1Lai/Bal-env-κB II-Mut, HIV-1Lai/Bal-env-κB I+II-Mut, or HIV-1Lai/Bal-env-N5-Mut and either; (A) left untreated, or (B) co-infected with MTb isolate CDC1551 (10∶1 cells∶bacilli). Viral p24 levels in culture supernatants were measured at days 4, 7 and 12 post-infection. (C) Histograms show viral p24 levels at day 12 in the MTb uninfected (grey bars) and MTb co-infected (black bars) PBMC cultures. Replication of the mutant viruses was compared to wild-type virus replication under the same experimental conditions (without and with MTb co-infection, respectively). *, p\u003c0.05; **, p\u003c0.01, as compared to HIV-1Lai/Bal-Env-WT."}