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PMC:3320587 / 194-1511 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T410 1306-1316 NN denotes expression
T409 1301-1305 NN denotes gene
T408 1298-1300 IN denotes of
T407 1290-1297 NN denotes control
T406 1277-1289 JJ denotes MTb-mediated
T405 1273-1276 CC denotes and
T404 1268-1272 NN denotes TLR-
T403 1265-1267 IN denotes in
T402 1259-1264 NN denotes NFAT5
T401 1255-1258 IN denotes for
T400 1250-1254 NN denotes role
T399 1242-1249 JJ denotes general
T398 1240-1241 DT denotes a
T397 1228-1239 VB denotes demonstrate
T396 1223-1227 RB denotes also
T395 1214-1222 NN denotes findings
T394 1208-1213 DT denotes These
T393 1198-1206 NN denotes promoter
T392 1192-1197 JJ denotes viral
T391 1188-1191 DT denotes the
T390 1183-1187 IN denotes with
T389 1171-1182 NN denotes interaction
T388 1164-1170 JJ denotes direct
T387 1162-1163 DT denotes a
T386 1158-1161 IN denotes via
T385 1146-1157 NN denotes replication
T384 1140-1145 NN denotes HIV-1
T383 1137-1139 IN denotes of
T382 1126-1136 NN denotes regulation
T381 1122-1125 NN denotes MTb
T380 1119-1121 IN denotes in
T379 1114-1118 NN denotes role
T378 1106-1113 JJ denotes crucial
T377 1104-1105 DT denotes a
T376 1098-1103 VB denotes plays
T375 1092-1097 NN denotes NFAT5
T374 1088-1091 CC denotes and
T373 1086-1087 -COMMA- denotes ,
T372 1076-1086 NN denotes expression
T371 1068-1075 NN denotes protein
T370 1064-1067 CC denotes and
T369 1059-1063 NN denotes gene
T368 1053-1058 NN denotes NFAT5
T367 1045-1052 VB denotes induces
T366 1035-1044 NN denotes infection
T365 1031-1034 NN denotes MTb
T364 1028-1030 TO denotes to
T363 1019-1027 NN denotes response
T362 1012-1018 JJ denotes immune
T361 1005-1011 JJ denotes innate
T360 1001-1004 DT denotes the
T359 999-1000 -COMMA- denotes ,
T358 995-999 RB denotes Thus
T357 983-993 NN denotes expression
T356 978-982 NN denotes gene
T355 972-977 NN denotes NFAT5
T354 960-971 JJ denotes MTb-induced
T353 951-959 VB denotes inhibits
T352 937-950 RB denotes significantly
T351 935-936 -COMMA- denotes ,
T350 930-935 NN denotes TRAF6
T349 926-929 CC denotes and
T348 924-925 -COMMA- denotes ,
T347 919-924 NN denotes IRAK1
T346 917-918 -COMMA- denotes ,
T345 912-917 NN denotes MyD88
T344 902-911 NN denotes molecules
T343 892-901 VB denotes signaling
T342 881-891 JJ denotes downstream
T341 877-880 DT denotes the
T340 867-876 VB denotes including
T339 865-866 -COMMA- denotes ,
T338 856-865 NN denotes monocytes
T337 850-855 JJ denotes human
T336 847-849 IN denotes in
T335 839-846 NN denotes pathway
T334 835-838 NN denotes TLR
T333 831-834 DT denotes the
T332 828-830 IN denotes of
T331 817-827 NN denotes components
T330 813-816 JJ denotes key
T329 810-812 IN denotes of
T328 805-809 NN denotes RNAi
T327 802-804 IN denotes by
T326 792-801 NN denotes silencing
T325 790-791 -COMMA- denotes ,
T324 779-790 RB denotes Furthermore
T323 774-777 NN denotes MTb
T322 771-773 IN denotes by
T321 759-770 NN denotes replication
T320 753-758 NN denotes HIV-1
T319 750-752 IN denotes of
T318 740-749 NN denotes induction
T317 731-739 JJ denotes efficent
T316 727-730 IN denotes for
T315 718-726 VB denotes required
T314 715-717 VB denotes is
T313 708-714 NN denotes clones
T312 698-707 JJ denotes molecular
T311 696-697 NN denotes C
T310 688-695 NN denotes subtype
T309 684-687 CC denotes and
T308 682-683 NN denotes B
T307 674-681 NN denotes subtype
T306 668-673 NN denotes HIV-1
T305 658-667 JJ denotes R5-tropic
T304 655-657 IN denotes of
T303 646-654 NN denotes promoter
T302 640-645 JJ denotes viral
T301 636-639 DT denotes the
T300 633-635 IN denotes in
T299 628-632 NN denotes site
T298 620-627 NN denotes binding
T297 614-619 NN denotes NFAT5
T296 607-613 JJ denotes intact
T295 604-606 DT denotes an
T294 599-603 IN denotes that
T293 595-598 CC denotes and
T292 593-594 -COMMA- denotes ,
T291 587-593 NN denotes ligand
T290 585-586 -RRB- denotes )
T289 582-585 NN denotes TLR
T288 581-582 -LRB- denotes (
T287 572-580 NN denotes receptor
T286 562-571 JJ denotes Toll-like
T285 560-561 DT denotes a
T284 557-559 VB denotes is
T283 551-556 WDT denotes which
T282 549-550 -COMMA- denotes ,
T281 546-549 NN denotes MTb
T280 543-545 IN denotes by
T279 535-542 VB denotes induced
T278 526-534 RB denotes strongly
T277 522-525 VB denotes are
T276 511-521 NN denotes expression
T275 503-510 NN denotes protein
T274 499-502 CC denotes and
T273 494-498 NN denotes gene
T272 488-493 NN denotes NFAT5
T271 483-487 IN denotes that
T270 478-482 VB denotes show
T269 475-477 PRP denotes We
T268 462-473 NN denotes macrophages
T267 450-461 JJ denotes co-infected
T266 447-449 IN denotes in
T265 435-446 NN denotes replication
T264 429-434 NN denotes HIV-1
T263 417-428 JJ denotes -stimulated
T262 416-417 -RRB- denotes )
T261 413-416 NN denotes MTb
T260 412-413 -LRB- denotes (
T259 399-411 NN denotes tuberculosis
T258 385-398 NN denotes Mycobacterium
T257 376-384 VB denotes inhibits
T256 374-375 -RRB- denotes )
T255 370-374 NN denotes RNAi
T254 369-370 -LRB- denotes (
T253 356-368 NN denotes interference
T252 352-355 NN denotes RNA
T251 349-351 IN denotes by
T250 347-348 -RRB- denotes )
T249 342-347 NN denotes NFAT5
T248 341-342 -LRB- denotes (
T247 339-340 CD denotes 5
T246 333-338 NN denotes cells
T245 331-332 NN denotes T
T244 321-330 VB denotes activated
T243 318-320 IN denotes of
T242 311-317 NN denotes factor
T241 303-310 JJ denotes nuclear
T240 296-302 NN denotes factor
T239 282-295 NN denotes transcription
T238 278-281 DT denotes the
T237 275-277 IN denotes of
T236 264-274 NN denotes expression
T235 260-263 DT denotes the
T234 257-259 IN denotes of
T233 247-256 NN denotes silencing
T232 242-246 IN denotes that
T231 230-241 VB denotes demonstrate
T230 227-229 PRP denotes we
T229 225-226 -COMMA- denotes ,
T228 221-225 RB denotes Here
T227 215-219 NN denotes load
T226 209-214 JJ denotes viral
T225 206-208 IN denotes in
T224 197-205 NN denotes increase
T223 194-196 DT denotes an
T222 191-193 TO denotes to
T221 183-190 VB denotes leading
T220 181-182 -COMMA- denotes ,
T219 170-181 NN denotes replication
T218 164-169 NN denotes HIV-1
T217 154-163 VB denotes stimulate
T216 149-153 WDT denotes that
T215 140-148 NN denotes cascades
T214 130-139 NN denotes signaling
T213 123-129 JJ denotes immune
T212 114-122 JJ denotes adaptive
T211 110-113 CC denotes and
T210 103-109 JJ denotes innate
T209 92-102 VB denotes activating
T195 0-12 NN denotes Tuberculosis
T196 13-14 -LRB- denotes (
T197 14-16 NN denotes TB
T198 16-17 -RRB- denotes )
T199 18-25 NN denotes disease
T200 26-28 IN denotes in
T201 29-32 NN denotes HIV
T202 33-44 JJ denotes co-infected
T203 45-53 NN denotes patients
T204 54-65 VB denotes contributes
T205 66-68 TO denotes to
T206 69-78 VB denotes increased
T207 79-88 NN denotes mortality
T208 89-91 IN denotes by
R45 T215 T214 arg1Of cascades,signaling
R46 T215 T216 arg1Of cascades,that
R47 T215 T217 arg1Of cascades,stimulate
R48 T217 T220 arg1Of stimulate,","
R49 T217 T221 modOf stimulate,leading
R50 T219 T217 arg2Of replication,stimulate
R51 T219 T218 arg1Of replication,HIV-1
R52 T221 T222 arg1Of leading,to
R53 T224 T222 arg2Of increase,to
R54 T224 T223 arg1Of increase,an
R55 T224 T225 arg1Of increase,in
R56 T227 T225 arg2Of load,in
R57 T227 T226 arg1Of load,viral
R58 T230 T231 arg1Of we,demonstrate
R59 T231 T228 arg1Of demonstrate,Here
R60 T231 T229 arg1Of demonstrate,","
R61 T233 T234 arg1Of silencing,of
R62 T233 T257 arg1Of silencing,inhibits
R63 T236 T234 arg2Of expression,of
R64 T236 T235 arg1Of expression,the
R65 T236 T237 arg1Of expression,of
R66 T242 T237 arg2Of factor,of
R67 T242 T238 arg1Of factor,the
R68 T242 T239 arg1Of factor,transcription
R69 T242 T240 arg1Of factor,factor
R70 T242 T241 arg1Of factor,nuclear
R71 T242 T243 arg1Of factor,of
R72 T242 T251 arg1Of factor,by
R73 T247 T243 arg2Of 5,of
R74 T247 T244 arg2Of 5,activated
R75 T247 T245 arg1Of 5,T
R76 T247 T246 arg1Of 5,cells
R77 T247 T248 arg1Of 5,(
R78 T249 T248 arg2Of NFAT5,(
R79 T250 T248 arg3Of ),(
R80 T253 T251 arg2Of interference,by
R81 T253 T252 arg1Of interference,RNA
R82 T253 T254 arg1Of interference,(
R83 T255 T254 arg2Of RNAi,(
R84 T256 T254 arg3Of ),(
R85 T257 T231 arg2Of inhibits,demonstrate
R86 T257 T232 arg1Of inhibits,that
R87 T261 T260 arg2Of MTb,(
R88 T262 T260 arg3Of ),(
R89 T265 T257 arg2Of replication,inhibits
R90 T265 T258 arg1Of replication,Mycobacterium
R91 T265 T259 arg1Of replication,tuberculosis
R92 T265 T260 arg1Of replication,(
R93 T265 T263 arg1Of replication,-stimulated
R94 T265 T264 arg1Of replication,HIV-1
R95 T265 T266 arg1Of replication,in
R96 T268 T266 arg2Of macrophages,in
R97 T268 T267 arg1Of macrophages,co-infected
R98 T269 T270 arg1Of We,show
R99 T273 T272 arg1Of gene,NFAT5
R100 T273 T274 arg1Of gene,and
R101 T274 T277 arg1Of and,are
R102 T274 T279 arg2Of and,induced
R103 T276 T274 arg2Of expression,and
R104 T276 T275 arg1Of expression,protein
R105 T279 T271 arg1Of induced,that
R106 T279 T277 arg2Of induced,are
R107 T279 T278 arg1Of induced,strongly
R108 T279 T293 arg1Of induced,and
R109 T281 T279 arg1Of MTb,induced
R110 T281 T280 arg2Of MTb,by
R111 T281 T282 arg1Of MTb,","
R112 T281 T283 arg1Of MTb,which
R113 T281 T284 arg1Of MTb,is
R114 T289 T288 arg2Of TLR,(
R115 T290 T288 arg3Of ),(
R116 T291 T284 arg2Of ligand,is
R117 T291 T285 arg1Of ligand,a
R118 T291 T286 arg1Of ligand,Toll-like
R119 T291 T287 arg1Of ligand,receptor
R120 T291 T288 arg1Of ligand,(
R121 T293 T270 arg2Of and,show
R122 T293 T292 arg1Of and,","
R123 T294 T293 arg2Of that,and
R124 T299 T295 arg1Of site,an
R125 T299 T296 arg1Of site,intact
R126 T299 T297 arg1Of site,NFAT5
R127 T299 T298 arg1Of site,binding
R128 T299 T300 arg1Of site,in
R129 T299 T314 arg1Of site,is
R130 T299 T315 arg2Of site,required
R131 T303 T300 arg2Of promoter,in
R132 T303 T301 arg1Of promoter,the
R133 T303 T302 arg1Of promoter,viral
R134 T303 T304 arg1Of promoter,of
R135 T308 T309 arg1Of B,and
R136 T310 T309 arg2Of subtype,and
R137 T313 T304 arg2Of clones,of
R138 T313 T305 arg1Of clones,R5-tropic
R139 T313 T306 arg1Of clones,HIV-1
R140 T313 T307 arg1Of clones,subtype
R141 T313 T308 arg1Of clones,B
R142 T313 T310 arg1Of clones,subtype
R143 T313 T311 arg1Of clones,C
R144 T313 T312 arg1Of clones,molecular
R145 T315 T294 arg2Of required,that
R146 T315 T314 arg2Of required,is
R147 T315 T316 arg1Of required,for
R148 T318 T316 arg2Of induction,for
R149 T318 T317 arg1Of induction,efficent
R150 T318 T319 arg1Of induction,of
R151 T318 T322 arg1Of induction,by
R152 T321 T319 arg2Of replication,of
R153 T321 T320 arg1Of replication,HIV-1
R154 T323 T322 arg2Of MTb,by
R155 T326 T327 arg1Of silencing,by
R156 T326 T329 arg1Of silencing,of
R157 T326 T353 arg1Of silencing,inhibits
R158 T328 T327 arg2Of RNAi,by
R159 T331 T329 arg2Of components,of
R160 T331 T330 arg1Of components,key
R161 T331 T332 arg1Of components,of
R162 T335 T332 arg2Of pathway,of
R163 T335 T333 arg1Of pathway,the
R164 T335 T334 arg1Of pathway,TLR
R165 T335 T336 arg1Of pathway,in
R166 T338 T336 arg2Of monocytes,in
R167 T338 T337 arg1Of monocytes,human
R168 T338 T339 arg1Of monocytes,","
R169 T338 T340 arg1Of monocytes,including
R170 T344 T341 arg1Of molecules,the
R171 T344 T342 arg1Of molecules,downstream
R172 T344 T343 arg1Of molecules,signaling
R173 T345 T346 arg1Of MyD88,","
R174 T346 T349 arg1Of ",",and
R175 T347 T346 arg2Of IRAK1,","
R176 T349 T340 arg2Of and,including
R177 T349 T344 arg1Of and,molecules
R178 T349 T348 arg1Of and,","
R179 T350 T349 arg2Of TRAF6,and
R180 T353 T324 arg1Of inhibits,Furthermore
R181 T353 T325 arg1Of inhibits,","
R182 T353 T351 arg1Of inhibits,","
R183 T353 T352 arg1Of inhibits,significantly
R184 T357 T353 arg2Of expression,inhibits
R185 T357 T354 arg1Of expression,MTb-induced
R186 T357 T355 arg1Of expression,NFAT5
R187 T357 T356 arg1Of expression,gene
R188 T363 T360 arg1Of response,the
R189 T363 T361 arg1Of response,innate
R190 T363 T362 arg1Of response,immune
R191 T363 T364 arg1Of response,to
R192 T363 T367 arg1Of response,induces
R193 T366 T364 arg2Of infection,to
R194 T366 T365 arg1Of infection,MTb
R195 T367 T358 arg1Of induces,Thus
R196 T367 T359 arg1Of induces,","
R197 T367 T374 arg1Of induces,and
R198 T369 T370 arg1Of gene,and
R199 T371 T370 arg2Of protein,and
R200 T372 T367 arg2Of expression,induces
R201 T372 T368 arg1Of expression,NFAT5
R202 T372 T369 arg1Of expression,gene
R203 T372 T371 arg1Of expression,protein
R204 T374 T373 arg1Of and,","
R205 T375 T376 arg1Of NFAT5,plays
R206 T376 T374 arg2Of plays,and
R207 T376 T380 arg1Of plays,in
R208 T376 T386 arg1Of plays,via
R209 T379 T376 arg2Of role,plays
R210 T379 T377 arg1Of role,a
R211 T379 T378 arg1Of role,crucial
R212 T382 T380 arg2Of regulation,in
R213 T382 T381 arg1Of regulation,MTb
R214 T382 T383 arg1Of regulation,of
R215 T385 T383 arg2Of replication,of
R216 T385 T384 arg1Of replication,HIV-1
R217 T389 T386 arg2Of interaction,via
R218 T389 T387 arg1Of interaction,a
R219 T389 T388 arg1Of interaction,direct
R220 T389 T390 arg1Of interaction,with
R221 T393 T390 arg2Of promoter,with
R222 T393 T391 arg1Of promoter,the
R223 T393 T392 arg1Of promoter,viral
R224 T395 T394 arg1Of findings,These
R225 T395 T397 arg1Of findings,demonstrate
R226 T397 T396 arg1Of demonstrate,also
R227 T400 T397 arg2Of role,demonstrate
R228 T400 T398 arg1Of role,a
R229 T400 T399 arg1Of role,general
R230 T400 T401 arg1Of role,for
R231 T400 T403 arg1Of role,in
R232 T402 T401 arg2Of NFAT5,for
R233 T404 T405 arg1Of TLR-,and
R234 T406 T405 arg2Of MTb-mediated,and
R235 T407 T403 arg2Of control,in
R236 T407 T404 arg1Of control,TLR-
R237 T407 T406 arg1Of control,MTb-mediated
R238 T407 T408 arg1Of control,of
R239 T410 T408 arg2Of expression,of
R240 T410 T409 arg1Of expression,gene
R38 T209 T208 arg2Of activating,by
R39 T210 T211 arg1Of innate,and
R40 T212 T211 arg2Of adaptive,and
R41 T215 T209 arg2Of cascades,activating
R42 T215 T210 arg1Of cascades,innate
R43 T215 T212 arg1Of cascades,adaptive
R44 T215 T213 arg1Of cascades,immune
R486 T195 T196 arg1Of Tuberculosis,(
R487 T197 T196 arg2Of TB,(
R488 T198 T196 arg3Of ),(
R489 T199 T195 arg1Of disease,Tuberculosis
R490 T199 T200 arg1Of disease,in
R491 T199 T204 arg1Of disease,contributes
R492 T199 T209 arg1Of disease,activating
R493 T203 T200 arg2Of patients,in
R494 T203 T201 arg1Of patients,HIV
R495 T203 T202 arg1Of patients,co-infected
R496 T204 T205 arg1Of contributes,to
R497 T204 T208 arg1Of contributes,by
R498 T207 T205 arg2Of mortality,to
R499 T207 T206 arg2Of mortality,increased

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T86 303-340 Protein denotes nuclear factor of activated T cells 5
T87 342-347 Protein denotes NFAT5
T88 488-493 Protein denotes NFAT5
T89 912-917 Protein denotes MyD88
T90 919-924 Protein denotes IRAK1
T91 930-935 Protein denotes TRAF6
T92 972-977 Protein denotes NFAT5
T93 1053-1058 Protein denotes NFAT5
T94 1092-1097 Protein denotes NFAT5
T95 1259-1264 Protein denotes NFAT5

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T412 342-347 http://www.uniprot.org/uniprot/O94916 denotes NFAT5
T413 488-493 http://www.uniprot.org/uniprot/O94916 denotes NFAT5
T414 614-619 http://www.uniprot.org/uniprot/O94916 denotes NFAT5
T415 972-977 http://www.uniprot.org/uniprot/O94916 denotes NFAT5
T416 1053-1058 http://www.uniprot.org/uniprot/O94916 denotes NFAT5
T417 1092-1097 http://www.uniprot.org/uniprot/O94916 denotes NFAT5
T418 1259-1264 http://www.uniprot.org/uniprot/O94916 denotes NFAT5
T419 912-917 http://www.uniprot.org/uniprot/Q99836 denotes MyD88
T420 930-935 http://www.uniprot.org/uniprot/Q9Y4K3 denotes TRAF6

GO-BP

Id Subject Object Predicate Lexical cue
T111 1005-1027 http://purl.obolibrary.org/obo/GO_0002218 denotes innate immune response
T110 1005-1027 http://purl.obolibrary.org/obo/GO_0045088 denotes innate immune response
T109 1005-1027 http://purl.obolibrary.org/obo/GO_0002227 denotes innate immune response
T108 1005-1027 http://purl.obolibrary.org/obo/GO_0045087 denotes innate immune response
T107 1301-1316 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T106 978-993 http://purl.obolibrary.org/obo/GO_0010467 denotes gene expression
T105 805-809 http://purl.obolibrary.org/obo/GO_0016246 denotes RNAi
T104 370-374 http://purl.obolibrary.org/obo/GO_0016246 denotes RNAi
T103 352-368 http://purl.obolibrary.org/obo/GO_0016246 denotes RNA interference
T102 130-148 http://purl.obolibrary.org/obo/GO_0007165 denotes signaling cascades
T101 892-901 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T100 130-139 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling
T99 282-295 http://purl.obolibrary.org/obo/GO_0006351 denotes transcription
T97 1126-1136 http://purl.obolibrary.org/obo/GO_0065007 denotes regulation
T114 1012-1027 http://purl.obolibrary.org/obo/GO_0006955 denotes immune response
T113 1005-1027 http://purl.obolibrary.org/obo/GO_0045824 denotes innate immune response
T112 1005-1027 http://purl.obolibrary.org/obo/GO_0045089 denotes innate immune response

GO-MF

Id Subject Object Predicate Lexical cue
T117 587-593 http://purl.obolibrary.org/obo/GO_0005488 denotes ligand
T118 620-627 http://purl.obolibrary.org/obo/GO_0005488 denotes binding

GO-CC

Id Subject Object Predicate Lexical cue
T119 333-338 http://purl.obolibrary.org/obo/GO_0005623 denotes cells

sentences

Id Subject Object Predicate Lexical cue
T63 1208-1317 Sentence denotes These findings also demonstrate a general role for NFAT5 in TLR- and MTb-mediated control of gene expression.
T62 995-1207 Sentence denotes Thus, the innate immune response to MTb infection induces NFAT5 gene and protein expression, and NFAT5 plays a crucial role in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter.
T61 779-994 Sentence denotes Furthermore, silencing by RNAi of key components of the TLR pathway in human monocytes, including the downstream signaling molecules MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression.
T60 475-778 Sentence denotes We show that NFAT5 gene and protein expression are strongly induced by MTb, which is a Toll-like receptor (TLR) ligand, and that an intact NFAT5 binding site in the viral promoter of R5-tropic HIV-1 subtype B and subtype C molecular clones is required for efficent induction of HIV-1 replication by MTb.
T59 221-474 Sentence denotes Here, we demonstrate that silencing of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits Mycobacterium tuberculosis (MTb)-stimulated HIV-1 replication in co-infected macrophages.
T58 0-220 Sentence denotes Tuberculosis (TB) disease in HIV co-infected patients contributes to increased mortality by activating innate and adaptive immune signaling cascades that stimulate HIV-1 replication, leading to an increase in viral load.
T4 0-220 Sentence denotes Tuberculosis (TB) disease in HIV co-infected patients contributes to increased mortality by activating innate and adaptive immune signaling cascades that stimulate HIV-1 replication, leading to an increase in viral load.
T5 221-474 Sentence denotes Here, we demonstrate that silencing of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits Mycobacterium tuberculosis (MTb)-stimulated HIV-1 replication in co-infected macrophages.
T6 475-778 Sentence denotes We show that NFAT5 gene and protein expression are strongly induced by MTb, which is a Toll-like receptor (TLR) ligand, and that an intact NFAT5 binding site in the viral promoter of R5-tropic HIV-1 subtype B and subtype C molecular clones is required for efficent induction of HIV-1 replication by MTb.
T7 779-994 Sentence denotes Furthermore, silencing by RNAi of key components of the TLR pathway in human monocytes, including the downstream signaling molecules MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression.
T8 995-1207 Sentence denotes Thus, the innate immune response to MTb infection induces NFAT5 gene and protein expression, and NFAT5 plays a crucial role in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter.
T9 1208-1317 Sentence denotes These findings also demonstrate a general role for NFAT5 in TLR- and MTb-mediated control of gene expression.

ICD10

Id Subject Object Predicate Lexical cue
T116 399-411 http://purl.bioontology.org/ontology/ICD10/A15-A19.9 denotes tuberculosis

simple1

Id Subject Object Predicate Lexical cue
T169 303-340 Protein denotes nuclear factor of activated T cells 5
T170 342-347 Protein denotes NFAT5
T171 488-493 Protein denotes NFAT5
T172 912-917 Protein denotes MyD88
T173 919-924 Protein denotes IRAK1
T174 930-935 Protein denotes TRAF6
T175 972-977 Protein denotes NFAT5
T176 1053-1058 Protein denotes NFAT5
T177 1092-1097 Protein denotes NFAT5
T178 1259-1264 Protein denotes NFAT5

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T756 303-340 Protein denotes nuclear factor of activated T cells 5
T757 342-347 Protein denotes NFAT5
T758 488-493 Protein denotes NFAT5
T759 912-917 Protein denotes MyD88
T760 919-924 Protein denotes IRAK1
T761 930-935 Protein denotes TRAF6
T762 972-977 Protein denotes NFAT5
T763 1092-1097 Protein denotes NFAT5
T764 1053-1058 Protein denotes NFAT5
T765 1259-1264 Protein denotes NFAT5
T767 247-256 Negative_regulation denotes silencing
T768 264-274 Gene_expression denotes expression
T769 535-542 Positive_regulation denotes induced
T770 511-521 Gene_expression denotes expression
T771 792-801 Negative_regulation denotes silencing
T772 960-971 Positive_regulation denotes MTb-induced
T773 951-959 Negative_regulation denotes inhibits
T774 983-993 Gene_expression denotes expression
T775 1045-1052 Positive_regulation denotes induces
T776 1076-1086 Gene_expression denotes expression
T777 1171-1182 Binding denotes interaction
R582 T757 T768 themeOf NFAT5,expression
R583 T758 T769 themeOf NFAT5,induced
R584 T758 T770 themeOf NFAT5,expression
R585 T759 T771 themeOf MyD88,silencing
R586 T760 T771 themeOf IRAK1,silencing
R587 T762 T774 themeOf NFAT5,expression
R588 T763 T777 themeOf NFAT5,interaction
R589 T764 T775 themeOf NFAT5,induces
R590 T764 T776 themeOf NFAT5,expression
R591 T768 T767 themeOf expression,silencing
R592 T770 T769 themeOf expression,induced
R593 T774 T773 themeOf expression,inhibits
R594 T774 T772 themeOf expression,MTb-induced
R595 T776 T775 themeOf expression,induces

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T442 303-340 Protein denotes nuclear factor of activated T cells 5
T443 342-347 Protein denotes NFAT5
T444 488-493 Protein denotes NFAT5
T445 912-917 Protein denotes MyD88
T446 919-924 Protein denotes IRAK1
T447 930-935 Protein denotes TRAF6
T448 972-977 Protein denotes NFAT5
T449 1092-1097 Protein denotes NFAT5
T450 1053-1058 Protein denotes NFAT5
T451 1259-1264 Protein denotes NFAT5
T452 264-274 Gene_expression denotes expression
T453 247-256 Negative_regulation denotes silencing
T454 535-542 Positive_regulation denotes induced
T455 511-521 Gene_expression denotes expression
T456 718-726 Positive_regulation denotes required
T457 740-749 Positive_regulation denotes induction
T458 983-993 Gene_expression denotes expression
T459 951-959 Negative_regulation denotes inhibits
T460 960-971 Positive_regulation denotes MTb-induced
T461 1076-1086 Gene_expression denotes expression
T462 1171-1182 Binding denotes interaction
T463 1045-1052 Positive_regulation denotes induces
R508 T443 T452 themeOf NFAT5,expression
R509 T444 T454 themeOf NFAT5,induced
R510 T444 T457 themeOf NFAT5,induction
R511 T444 T455 themeOf NFAT5,expression
R512 T448 T458 themeOf NFAT5,expression
R513 T449 T462 themeOf NFAT5,interaction
R514 T450 T463 themeOf NFAT5,induces
R515 T450 T461 themeOf NFAT5,expression
R516 T450 T462 themeOf NFAT5,interaction
R517 T452 T453 themeOf expression,silencing
R518 T455 T454 themeOf expression,induced
R519 T457 T456 themeOf induction,required
R520 T458 T459 themeOf expression,inhibits
R521 T458 T460 themeOf expression,MTb-induced
R522 T461 T463 themeOf expression,induces

DLUT931

Id Subject Object Predicate Lexical cue
T440 1045-1052 Positive_regulation denotes induces
T439 1171-1182 Binding denotes interaction
T438 1076-1086 Gene_expression denotes expression
T437 951-959 Negative_regulation denotes inhibits
T436 960-971 Positive_regulation denotes MTb-induced
T435 983-993 Gene_expression denotes expression
T434 535-542 Positive_regulation denotes induced
T422 303-340 Protein denotes nuclear factor of activated T cells 5
T423 342-347 Protein denotes NFAT5
T424 488-493 Protein denotes NFAT5
T425 912-917 Protein denotes MyD88
T426 919-924 Protein denotes IRAK1
T427 930-935 Protein denotes TRAF6
T428 972-977 Protein denotes NFAT5
T429 1092-1097 Protein denotes NFAT5
T430 1053-1058 Protein denotes NFAT5
T431 1259-1264 Protein denotes NFAT5
T432 264-274 Gene_expression denotes expression
T433 511-521 Gene_expression denotes expression
R241 T435 T436 themeOf expression,MTb-induced
R242 T436 T437 themeOf MTb-induced,inhibits
R243 T438 T440 themeOf expression,induces
R500 T422 T432 themeOf nuclear factor of activated T cells 5,expression
R501 T423 T432 themeOf NFAT5,expression
R502 T424 T433 themeOf NFAT5,expression
R503 T424 T434 themeOf NFAT5,induced
R504 T428 T435 themeOf NFAT5,expression
R505 T429 T439 themeOf NFAT5,interaction
R506 T430 T438 themeOf NFAT5,expression
R507 T433 T434 themeOf expression,induced

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T823 604-632 Binding denotes an intact NFAT5 binding site
T822 1031-1044 Regulation denotes MTb infection
T821 275-384 Negative_regulation denotes of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T820 912-993 Negative_regulation denotes MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression
T819 1277-1316 Regulation denotes MTb-mediated control of gene expression
T818 1068-1086 Gene_expression denotes protein expression
T817 960-993 Gene_expression denotes MTb-induced NFAT5 gene expression
T816 503-521 Gene_expression denotes protein expression
T815 1171-1206 Binding denotes interaction with the viral promoter
T814 1119-1206 Regulation denotes in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter
T813 227-384 Negative_regulation denotes we demonstrate that silencing of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T812 257-384 Gene_expression denotes of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T811 1277-1316 Regulation denotes MTb-mediated control of gene expression
T810 543-549 Protein denotes by MTb
T809 488-498 Protein denotes NFAT5 gene
T808 902-911 Entity denotes molecules
T778 1053-1058 Protein denotes NFAT5
T779 1031-1034 Protein denotes MTb
T780 562-594 Entity denotes Toll-like receptor (TLR) ligand,
T781 912-936 Protein denotes MyD88, IRAK1, and TRAF6,
T782 636-681 Entity denotes the viral promoter of R5-tropic HIV-1 subtype
T783 1122-1125 Protein denotes MTb
T784 1053-1063 Protein denotes NFAT5 gene
T785 1183-1206 Entity denotes with the viral promoter
T786 450-473 Entity denotes co-infected macrophages
T787 771-777 Protein denotes by MTb
T788 614-619 Protein denotes NFAT5
T789 1277-1289 Protein denotes MTb-mediated
T790 604-632 Entity denotes an intact NFAT5 binding site
T791 850-866 Entity denotes human monocytes,
T792 919-925 Protein denotes IRAK1,
T793 1068-1075 Protein denotes protein
T794 972-977 Protein denotes NFAT5
T795 275-384 Protein denotes of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
T796 562-586 Protein denotes Toll-like receptor (TLR)
T797 303-348 Protein denotes nuclear factor of activated T cells 5 (NFAT5)
T799 1092-1097 Protein denotes NFAT5
T800 488-493 Protein denotes NFAT5
T801 960-971 Protein denotes MTb-induced
T802 930-935 Protein denotes TRAF6
T803 342-347 Protein denotes NFAT5
T804 413-416 Protein denotes MTb
T806 503-510 Protein denotes protein
T807 1259-1264 Protein denotes NFAT5
R603 T795 T812 themeOf of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits,of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R604 T795 T821 themeOf of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits,of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R605 T797 T821 causeOf nuclear factor of activated T cells 5 (NFAT5),of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R606 T806 T816 themeOf protein,protein expression
R454 T811 T819 themeOf MTb-mediated control of gene expression,MTb-mediated control of gene expression
R455 T812 T813 themeOf of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits,we demonstrate that silencing of the expression of the transcription factor nuclear factor of activated T cells 5 (NFAT5) by RNA interference (RNAi) inhibits
R456 T815 T814 themeOf interaction with the viral promoter,in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter
R457 T817 T820 themeOf MTb-induced NFAT5 gene expression,"MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression"
R596 T779 T822 themeOf MTb,MTb infection
R597 T781 T820 causeOf "MyD88, IRAK1, and TRAF6,","MyD88, IRAK1, and TRAF6, significantly inhibits MTb-induced NFAT5 gene expression"
R598 T785 T815 themeOf with the viral promoter,interaction with the viral promoter
R599 T789 T819 causeOf MTb-mediated,MTb-mediated control of gene expression
R600 T790 T823 themeOf an intact NFAT5 binding site,an intact NFAT5 binding site
R601 T793 T818 themeOf protein,protein expression
R602 T794 T817 themeOf NFAT5,MTb-induced NFAT5 gene expression

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T754 1316-1317 . denotes .
T753 1306-1316 NN denotes expression
T752 1301-1305 NN denotes gene
T751 1298-1300 IN denotes of
T750 1290-1297 NN denotes control
T749 1277-1289 JJ denotes MTb-mediated
T748 1273-1276 CC denotes and
T747 1271-1272 : denotes -
T746 1268-1271 NNP denotes TLR
T745 1265-1267 IN denotes in
T744 1259-1264 NNP denotes NFAT5
T743 1255-1258 IN denotes for
T742 1250-1254 NN denotes role
T741 1242-1249 JJ denotes general
T740 1240-1241 DT denotes a
T739 1228-1239 VBP denotes demonstrate
T738 1223-1227 RB denotes also
T737 1214-1222 NNS denotes findings
T736 1208-1213 DT denotes These
T735 1206-1207 . denotes .
T734 1198-1206 NN denotes promoter
T733 1192-1197 JJ denotes viral
T732 1188-1191 DT denotes the
T731 1183-1187 IN denotes with
T730 1171-1182 NN denotes interaction
T729 1164-1170 JJ denotes direct
T728 1162-1163 DT denotes a
T727 1158-1161 IN denotes via
T726 1146-1157 NN denotes replication
T725 1140-1145 JJ denotes HIV-1
T724 1137-1139 IN denotes of
T723 1126-1136 NN denotes regulation
T722 1122-1125 NNP denotes MTb
T721 1119-1121 IN denotes in
T720 1114-1118 NN denotes role
T719 1106-1113 JJ denotes crucial
T718 1104-1105 DT denotes a
T717 1098-1103 VBZ denotes plays
T716 1092-1097 NNP denotes NFAT5
T715 1088-1091 CC denotes and
T714 1086-1087 , denotes ,
T713 1076-1086 NN denotes expression
T712 1068-1075 NN denotes protein
T711 1064-1067 CC denotes and
T710 1059-1063 NN denotes gene
T709 1053-1058 NNP denotes NFAT5
T708 1045-1052 VBZ denotes induces
T707 1035-1044 NN denotes infection
T706 1031-1034 NNP denotes MTb
T705 1028-1030 TO denotes to
T704 1019-1027 NN denotes response
T703 1012-1018 JJ denotes immune
T702 1005-1011 NN denotes innate
T701 1001-1004 DT denotes the
T700 999-1000 , denotes ,
T699 995-999 RB denotes Thus
T698 993-994 . denotes .
T697 983-993 NN denotes expression
T696 978-982 NN denotes gene
T695 972-977 CD denotes NFAT5
T694 960-971 JJ denotes MTb-induced
T693 951-959 VBZ denotes inhibits
T692 937-950 RB denotes significantly
T691 935-936 , denotes ,
T690 930-935 NNP denotes TRAF6
T689 926-929 CC denotes and
T688 924-925 , denotes ,
T687 919-924 NNP denotes IRAK1
T686 917-918 , denotes ,
T685 912-917 NNP denotes MyD88
T684 902-911 NNS denotes molecules
T683 892-901 VBG denotes signaling
T647 682-683 NNP denotes B
T646 674-681 NN denotes subtype
T645 668-673 NN denotes HIV-1
T644 658-667 JJ denotes R5-tropic
T643 655-657 IN denotes of
T642 646-654 NN denotes promoter
T641 640-645 JJ denotes viral
T640 636-639 DT denotes the
T639 633-635 IN denotes in
T638 628-632 NN denotes site
T637 620-627 JJ denotes binding
T636 614-619 NNP denotes NFAT5
T635 607-613 JJ denotes intact
T634 604-606 DT denotes an
T633 599-603 IN denotes that
T632 595-598 CC denotes and
T631 593-594 , denotes ,
T630 587-593 NN denotes ligand
T629 585-586 -RRB- denotes )
T628 582-585 NNP denotes TLR
T627 581-582 -LRB- denotes (
T626 572-580 NN denotes receptor
T625 562-571 JJ denotes Toll-like
T624 560-561 DT denotes a
T623 557-559 VBZ denotes is
T622 551-556 WDT denotes which
T621 549-550 , denotes ,
T620 546-549 NNP denotes MTb
T619 543-545 IN denotes by
T618 535-542 VBN denotes induced
T617 526-534 RB denotes strongly
T616 522-525 VBP denotes are
T615 511-521 NN denotes expression
T614 503-510 NN denotes protein
T613 499-502 CC denotes and
T612 494-498 NN denotes gene
T611 488-493 CD denotes NFAT5
T610 483-487 IN denotes that
T609 478-482 VBP denotes show
T608 475-477 PRP denotes We
T607 473-474 . denotes .
T606 462-473 NNS denotes macrophages
T605 450-461 JJ denotes co-infected
T604 447-449 IN denotes in
T603 435-446 NN denotes replication
T602 429-434 NNP denotes HIV-1
T601 418-428 VBN denotes stimulated
T600 417-418 : denotes -
T599 416-417 -RRB- denotes )
T598 413-416 NNP denotes MTb
T597 412-413 -LRB- denotes (
T596 399-411 NN denotes tuberculosis
T595 385-398 NNP denotes Mycobacterium
T594 376-384 VBZ denotes inhibits
T593 374-375 -RRB- denotes )
T592 370-374 NNS denotes RNAi
T591 369-370 -LRB- denotes (
T590 356-368 NN denotes interference
T589 352-355 NNP denotes RNA
T588 349-351 IN denotes by
T568 230-241 VBP denotes demonstrate
T567 227-229 PRP denotes we
T566 225-226 , denotes ,
T565 221-225 RB denotes Here
T564 219-220 . denotes .
T563 215-219 NN denotes load
T562 209-214 JJ denotes viral
T561 206-208 IN denotes in
T560 197-205 NN denotes increase
T559 194-196 DT denotes an
T558 191-193 TO denotes to
T557 183-190 VBG denotes leading
T556 181-182 , denotes ,
T555 170-181 NN denotes replication
T554 164-169 JJ denotes HIV-1
T553 154-163 VBP denotes stimulate
T552 149-153 WDT denotes that
T551 140-148 NNS denotes cascades
T550 130-139 VBG denotes signaling
T549 123-129 JJ denotes immune
T548 114-122 JJ denotes adaptive
T547 110-113 CC denotes and
T546 103-109 NN denotes innate
T545 92-102 VBG denotes activating
T544 89-91 IN denotes by
T543 79-88 NN denotes mortality
T542 69-78 VBN denotes increased
T541 66-68 TO denotes to
T540 54-65 VBZ denotes contributes
T539 45-53 NNS denotes patients
T538 33-44 VBD denotes co-infected
T537 29-32 NNP denotes HIV
T536 26-28 IN denotes in
T535 18-25 NN denotes disease
T534 16-17 -RRB- denotes )
T533 14-16 NN denotes TB
T532 13-14 -LRB- denotes (
T531 0-12 NNP denotes Tuberculosis
T569 242-246 IN denotes that
T570 247-256 VBG denotes silencing
T571 257-259 IN denotes of
T572 260-263 DT denotes the
T573 264-274 NN denotes expression
T574 275-277 IN denotes of
T575 278-281 DT denotes the
T576 282-295 NN denotes transcription
T577 296-302 NN denotes factor
T578 303-310 JJ denotes nuclear
T579 311-317 NN denotes factor
T580 318-320 IN denotes of
T581 321-330 VBN denotes activated
T582 331-332 NNP denotes T
T583 333-338 NNS denotes cells
T584 339-340 CD denotes 5
T585 341-342 -LRB- denotes (
T586 342-347 CD denotes NFAT5
T587 347-348 -RRB- denotes )
T648 684-687 CC denotes and
T649 688-695 JJ denotes subtype
T650 696-697 NNP denotes C
T651 698-707 JJ denotes molecular
T652 708-714 NNS denotes clones
T653 715-717 VBZ denotes is
T654 718-726 VBN denotes required
T655 727-730 IN denotes for
T656 731-739 JJ denotes efficent
T657 740-749 NN denotes induction
T658 750-752 IN denotes of
T659 753-758 JJ denotes HIV-1
T660 759-770 NN denotes replication
T661 771-773 IN denotes by
T662 774-777 NNP denotes MTb
T663 777-778 . denotes .
T664 779-790 RB denotes Furthermore
T665 790-791 , denotes ,
T666 792-801 VBG denotes silencing
T667 802-804 IN denotes by
T668 805-809 NNS denotes RNAi
T669 810-812 IN denotes of
T670 813-816 JJ denotes key
T671 817-827 NNS denotes components
T672 828-830 IN denotes of
T673 831-834 DT denotes the
T674 835-838 NNP denotes TLR
T675 839-846 NN denotes pathway
T676 847-849 IN denotes in
T677 850-855 JJ denotes human
T678 856-865 NNS denotes monocytes
T679 865-866 , denotes ,
T680 867-876 VBG denotes including
T681 877-880 DT denotes the
T682 881-891 JJ denotes downstream
R285 T532 T531 punct (,Tuberculosis
R286 T533 T531 appos TB,Tuberculosis
R287 T534 T531 punct ),Tuberculosis
R289 T536 T535 prep in,disease
R290 T537 T536 pobj HIV,in
R291 T538 T539 amod co-infected,patients
R294 T541 T540 prep to,contributes
R295 T542 T543 amod increased,mortality
R296 T543 T541 pobj mortality,to
R297 T544 T540 prep by,contributes
R298 T545 T544 pcomp activating,by
R299 T546 T545 dobj innate,activating
R300 T547 T546 cc and,innate
R301 T548 T550 amod adaptive,signaling
R302 T549 T550 amod immune,signaling
R303 T550 T545 conj signaling,activating
R304 T551 T550 dobj cascades,signaling
R305 T552 T553 nsubj that,stimulate
R306 T553 T551 relcl stimulate,cascades
R307 T554 T555 compound HIV-1,replication
R308 T555 T553 dobj replication,stimulate
R309 T556 T550 punct ",",signaling
R310 T557 T550 conj leading,signaling
R311 T558 T557 prep to,leading
R312 T559 T560 det an,increase
R313 T560 T558 pobj increase,to
R314 T561 T560 prep in,increase
R315 T562 T563 amod viral,load
R316 T563 T561 pobj load,in
R318 T565 T568 advmod Here,demonstrate
R319 T566 T568 punct ",",demonstrate
R320 T567 T568 nsubj we,demonstrate
R321 T568 T568 ROOT demonstrate,demonstrate
R322 T588 T570 prep by,silencing
R323 T589 T590 compound RNA,interference
R324 T590 T588 pobj interference,by
R325 T591 T592 punct (,RNAi
R326 T592 T570 appos RNAi,silencing
R327 T593 T570 punct ),silencing
R328 T594 T568 ccomp inhibits,demonstrate
R329 T595 T596 compound Mycobacterium,tuberculosis
R330 T596 T594 dobj tuberculosis,inhibits
R331 T597 T596 punct (,tuberculosis
R332 T598 T596 appos MTb,tuberculosis
R333 T599 T596 punct ),tuberculosis
R334 T600 T596 punct -,tuberculosis
R335 T601 T568 advcl stimulated,demonstrate
R336 T602 T603 compound HIV-1,replication
R337 T603 T601 dobj replication,stimulated
R338 T604 T603 prep in,replication
R339 T605 T606 amod co-infected,macrophages
R340 T606 T604 pobj macrophages,in
R341 T607 T568 punct .,demonstrate
R342 T608 T609 nsubj We,show
R343 T609 T609 ROOT show,show
R344 T610 T618 mark that,induced
R345 T611 T618 nsubjpass NFAT5,induced
R346 T612 T618 nsubjpass gene,induced
R347 T613 T612 cc and,gene
R348 T614 T615 compound protein,expression
R349 T615 T612 conj expression,gene
R350 T616 T618 auxpass are,induced
R351 T617 T618 advmod strongly,induced
R352 T618 T609 ccomp induced,show
R353 T619 T618 agent by,induced
R354 T620 T619 pobj MTb,by
R355 T621 T620 punct ",",MTb
R356 T622 T623 nsubj which,is
R357 T623 T620 relcl is,MTb
R358 T624 T626 det a,receptor
R359 T625 T626 amod Toll-like,receptor
R360 T626 T623 attr receptor,is
R361 T627 T628 punct (,TLR
R362 T628 T623 npadvmod TLR,is
R363 T629 T618 punct ),induced
R364 T630 T618 conj ligand,induced
R365 T631 T630 punct ",",ligand
R366 T632 T618 cc and,induced
R367 T633 T654 mark that,required
R368 T634 T638 det an,site
R369 T635 T638 amod intact,site
R370 T636 T638 nmod NFAT5,site
R371 T637 T638 amod binding,site
R372 T638 T654 nsubjpass site,required
R373 T639 T638 prep in,site
R374 T640 T642 det the,promoter
R375 T641 T642 amod viral,promoter
R376 T642 T639 pobj promoter,in
R377 T643 T642 prep of,promoter
R378 T644 T647 nmod R5-tropic,B
R379 T645 T647 nmod HIV-1,B
R380 T646 T647 compound subtype,B
R381 T647 T652 nmod B,clones
R382 T683 T684 amod signaling,molecules
R383 T684 T680 pobj molecules,including
R384 T685 T680 pobj MyD88,including
R385 T686 T685 punct ",",MyD88
R386 T687 T685 conj IRAK1,MyD88
R387 T688 T687 punct ",",IRAK1
R388 T689 T687 cc and,IRAK1
R389 T690 T687 conj TRAF6,IRAK1
R390 T691 T693 punct ",",inhibits
R391 T692 T693 advmod significantly,inhibits
R392 T693 T693 ROOT inhibits,inhibits
R393 T694 T697 amod MTb-induced,expression
R394 T695 T697 nummod NFAT5,expression
R395 T696 T697 compound gene,expression
R396 T697 T693 dobj expression,inhibits
R397 T698 T693 punct .,inhibits
R398 T699 T708 advmod Thus,induces
R399 T700 T708 punct ",",induces
R400 T701 T704 det the,response
R401 T702 T704 amod innate,response
R402 T703 T704 amod immune,response
R403 T704 T708 nsubj response,induces
R404 T705 T704 prep to,response
R405 T706 T707 compound MTb,infection
R406 T707 T705 pobj infection,to
R407 T708 T708 ROOT induces,induces
R408 T709 T710 compound NFAT5,gene
R409 T710 T708 dobj gene,induces
R410 T711 T710 cc and,gene
R411 T712 T713 compound protein,expression
R412 T713 T710 conj expression,gene
R413 T714 T708 punct ",",induces
R414 T715 T708 cc and,induces
R415 T716 T717 nsubj NFAT5,plays
R416 T717 T708 conj plays,induces
R417 T718 T720 det a,role
R418 T719 T720 amod crucial,role
R419 T720 T717 dobj role,plays
R420 T721 T720 prep in,role
R421 T722 T723 compound MTb,regulation
R422 T723 T721 pobj regulation,in
R423 T724 T723 prep of,regulation
R424 T725 T726 compound HIV-1,replication
R425 T726 T724 pobj replication,of
R426 T727 T717 prep via,plays
R427 T728 T730 det a,interaction
R428 T729 T730 amod direct,interaction
R429 T730 T727 pobj interaction,via
R430 T731 T730 prep with,interaction
R431 T732 T734 det the,promoter
R432 T733 T734 amod viral,promoter
R433 T734 T731 pobj promoter,with
R434 T735 T717 punct .,plays
R435 T736 T737 det These,findings
R436 T737 T739 nsubj findings,demonstrate
R437 T738 T739 advmod also,demonstrate
R438 T739 T739 ROOT demonstrate,demonstrate
R439 T740 T742 det a,role
R440 T741 T742 amod general,role
R441 T742 T739 dobj role,demonstrate
R442 T743 T739 prep for,demonstrate
R443 T744 T743 pobj NFAT5,for
R444 T745 T744 prep in,NFAT5
R445 T746 T745 pobj TLR,in
R446 T747 T744 punct -,NFAT5
R447 T748 T744 cc and,NFAT5
R448 T749 T750 amod MTb-mediated,control
R449 T750 T744 conj control,NFAT5
R450 T751 T750 prep of,control
R451 T752 T753 compound gene,expression
R452 T753 T751 pobj expression,of
R453 T754 T739 punct .,demonstrate
R527 T569 T594 mark that,inhibits
R528 T570 T594 csubj silencing,inhibits
R529 T571 T570 prep of,silencing
R530 T572 T573 det the,expression
R531 T573 T571 pobj expression,of
R532 T574 T573 prep of,expression
R533 T575 T577 det the,factor
R534 T576 T577 compound transcription,factor
R535 T577 T574 pobj factor,of
R536 T578 T579 amod nuclear,factor
R537 T579 T573 conj factor,expression
R538 T580 T573 prep of,expression
R539 T581 T583 amod activated,cells
R540 T582 T583 compound T,cells
R541 T583 T580 pobj cells,of
R542 T584 T570 nummod 5,silencing
R543 T585 T586 punct (,NFAT5
R544 T586 T584 prep NFAT5,5
R545 T587 T584 punct ),5
R546 T648 T647 cc and,B
R547 T649 T652 amod subtype,clones
R548 T650 T652 nmod C,clones
R549 T651 T652 amod molecular,clones
R550 T652 T643 pobj clones,of
R551 T653 T654 auxpass is,required
R552 T654 T618 conj required,induced
R553 T655 T654 prep for,required
R554 T656 T657 amod efficent,induction
R555 T657 T655 pobj induction,for
R556 T658 T657 prep of,induction
R557 T659 T660 compound HIV-1,replication
R558 T660 T658 pobj replication,of
R559 T661 T657 prep by,induction
R560 T662 T661 pobj MTb,by
R561 T663 T609 punct .,show
R562 T664 T693 advmod Furthermore,inhibits
R563 T665 T693 punct ",",inhibits
R564 T666 T693 advcl silencing,inhibits
R565 T667 T666 prep by,silencing
R566 T668 T667 pobj RNAi,by
R567 T669 T668 prep of,RNAi
R568 T670 T671 amod key,components
R569 T671 T669 pobj components,of
R570 T672 T671 prep of,components
R571 T673 T675 det the,pathway
R572 T674 T675 compound TLR,pathway
R573 T675 T672 pobj pathway,of
R574 T676 T675 prep in,pathway
R575 T677 T678 amod human,monocytes
R576 T678 T676 pobj monocytes,in
R577 T679 T678 punct ",",monocytes
R578 T680 T678 prep including,monocytes
R579 T681 T684 det the,molecules
R580 T682 T684 amod downstream,molecules

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T156 1268-1271 Protein denotes TLR
T155 1259-1264 Protein denotes NFAT5
T154 1045-1052 Positive_regulation denotes induces
T153 1171-1182 Binding denotes interaction
T152 1076-1086 Gene_expression denotes expression
T151 1122-1125 Protein denotes MTb
T150 1092-1097 Protein denotes NFAT5
T149 1053-1063 Protein denotes NFAT5 gene
T148 951-959 Negative_regulation denotes inhibits
T147 951-959 Negative_regulation denotes inhibits
T146 951-959 Negative_regulation denotes inhibits
T145 960-971 Positive_regulation denotes MTb-induced
T144 983-993 Gene_expression denotes expression
T143 792-801 Negative_regulation denotes silencing
T142 792-801 Negative_regulation denotes silencing
T141 792-801 Negative_regulation denotes silencing
T140 972-982 Protein denotes NFAT5 gene
T139 930-935 Protein denotes TRAF6
T138 919-924 Protein denotes IRAK1
T137 912-917 Protein denotes MyD88
T136 835-838 Protein denotes TLR
T135 535-542 Positive_regulation denotes induced
T134 535-542 Positive_regulation denotes induced
T133 511-521 Gene_expression denotes expression
T132 614-632 Protein denotes NFAT5 binding site
T131 488-498 Protein denotes NFAT5 gene
T130 247-256 Negative_regulation denotes silencing
T129 247-256 Negative_regulation denotes silencing
T128 247-256 Negative_regulation denotes silencing
T127 264-274 Gene_expression denotes expression
T122 282-317 Protein denotes transcription factor nuclear factor
T123 321-340 Protein denotes activated T cells 5
T124 342-347 Protein denotes NFAT5
T125 264-274 Gene_expression denotes expression
T126 264-274 Gene_expression denotes expression
R22 T133 T135 themeOf expression,induced
R19 T127 T130 themeOf expression,silencing
R20 T131 T133 themeOf NFAT5 gene,expression
R21 T131 T134 themeOf NFAT5 gene,induced
R466 T122 T125 themeOf transcription factor nuclear factor,expression
R467 T123 T126 themeOf activated T cells 5,expression
R468 T124 T127 themeOf NFAT5,expression
R469 T125 T128 themeOf expression,silencing
R470 T126 T129 themeOf expression,silencing
R23 T137 T141 themeOf MyD88,silencing
R24 T138 T142 themeOf IRAK1,silencing
R25 T139 T143 themeOf TRAF6,silencing
R26 T140 T144 themeOf NFAT5 gene,expression
R27 T141 T146 causeOf silencing,inhibits
R28 T142 T147 causeOf silencing,inhibits
R30 T144 T145 themeOf expression,MTb-induced
R31 T145 T146 themeOf MTb-induced,inhibits
R32 T145 T147 themeOf MTb-induced,inhibits
R29 T143 T148 causeOf silencing,inhibits
R33 T145 T148 themeOf MTb-induced,inhibits
R34 T149 T152 themeOf NFAT5 gene,expression
R35 T150 T153 themeOf NFAT5,interaction
R36 T151 T153 themeOf MTb,interaction
R37 T152 T154 themeOf expression,induces

testone

Id Subject Object Predicate Lexical cue
T31 1171-1182 Binding denotes interaction
T30 1076-1086 Gene_expression denotes expression
T29 1045-1052 Positive_regulation denotes induces
T28 983-993 Gene_expression denotes expression
T27 964-971 Positive_regulation denotes induced
T26 951-959 Negative_regulation denotes inhibits
T25 792-801 Negative_regulation denotes silencing
T24 535-542 Positive_regulation denotes induced
T23 247-256 Negative_regulation denotes silencing
T22 1259-1264 Protein denotes NFAT5
T21 1092-1097 Protein denotes NFAT5
T20 1053-1058 Protein denotes NFAT5
T19 972-977 Protein denotes NFAT5
T18 930-935 Protein denotes TRAF6
T17 919-924 Protein denotes IRAK1
T16 912-917 Protein denotes MyD88
T15 488-493 Protein denotes NFAT5
T14 342-347 Protein denotes NFAT5
T13 303-340 Protein denotes nuclear factor of activated T cells 5
R3 T18 T26 causeOf TRAF6,inhibits
R4 T19 T28 themeOf NFAT5,expression
R5 T20 T30 themeOf NFAT5,expression
R6 T21 T31 themeOf NFAT5,interaction
R7 T21 T29 themeOf NFAT5,induces
R8 T27 T26 themeOf induced,inhibits
R9 T28 T27 themeOf expression,induced
R10 T30 T29 themeOf expression,induces
R1 T14 T13 equivalentTo NFAT5,nuclear factor of activated T cells 5
R2 T17 T26 causeOf IRAK1,inhibits

test3

Id Subject Object Predicate Lexical cue
T45 342-347 Protein denotes NFAT5
T44 303-340 Protein denotes nuclear factor of activated T cells 5
T42 1259-1264 Protein denotes NFAT5
T41 1092-1097 Protein denotes NFAT5
T40 1053-1058 Protein denotes NFAT5
T39 972-977 Protein denotes NFAT5
T38 930-935 Protein denotes TRAF6
T37 919-924 Protein denotes IRAK1
T36 912-917 Protein denotes MyD88
T35 488-493 Protein denotes NFAT5
T34 342-347 Protein denotes NFAT5
T33 303-340 Protein denotes nuclear factor of activated T cells 5
T56 1259-1264 Protein denotes NFAT5
T55 1171-1182 Binding denotes interaction
T54 1092-1097 Protein denotes NFAT5
T53 1076-1086 Gene_expression denotes expression
T52 1053-1058 Protein denotes NFAT5
T51 972-977 Protein denotes NFAT5
T50 930-935 Protein denotes TRAF6
T49 919-924 Protein denotes IRAK1
T48 912-917 Protein denotes MyD88
T47 535-542 Positive_regulation denotes induced
T46 488-493 Protein denotes NFAT5
R11 T45 T44 equivalentTo NFAT5,nuclear factor of activated T cells 5
R12 T46 T47 themeOf NFAT5,induced
R13 T52 T55 themeOf NFAT5,interaction
R14 T52 T53 themeOf NFAT5,expression
R15 T54 T55 themeOf NFAT5,interaction