PMC:3317825 / 872-1944 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3317825","sourcedb":"PMC","sourceid":"3317825","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3317825","text":"Results\nWe determined a Roche/454 draft genome sequence for S. simiae and included it in comparative genomic analyses with 11 other Staphylococcus species including S. aureus. A genome based phylogeny of the genus confirms that S. simiae is the sister group to S. aureus and indicates that the most basal Staphylococcus lineage is Staphylococcus pseudintermedius, followed by Staphylococcus carnosus. Given the primary niche of these two latter taxa, compared to the other species in the genus, this phylogeny suggests that human adaptation evolved after the split of S. carnosus. The two coagulase-positive species (S. aureus and S. pseudintermedius) are not phylogenetically closest but share many virulence factors exclusively, suggesting that these genes were acquired by horizontal transfer. Enrichment in genes related to mobile elements such as prophage in S. aureus relative to S. simiae suggests that pathogenesis in the S. aureus group has developed by gene gain through horizontal transfer, after the split of S. aureus and S. simiae from their common ancestor.","divisions":[{"label":"Title","span":{"begin":0,"end":7}}],"tracks":[]}