PMC:3317825 / 2156-3421
Annnotations
{"target":"https://pubannotation.org/docs/sourcedb/PMC/sourceid/3317825","sourcedb":"PMC","sourceid":"3317825","source_url":"http://www.ncbi.nlm.nih.gov/pmc/3317825","text":"Background\nStaphylococcus belongs to the Gram-positive low G + C content group of the Firmicutes division of bacteria. Staphylococcus aureus is an important human and veterinary pathogen that causes a broad spectrum of diseases, and has developed important multidrug resistant forms such as methicillin-resistant S. aureus (MRSA) and vancomycin-resistant S. aureus (VRSA) [1-3]. Despite emergence of MRSA in human and various animal species, mechanisms of host adaptation are poorly understood [4]. Comparative genomic analyses of phylogenetically closely related bacteria with different phenotypes (e.g. host specificity and pathogenicity) can provide information relevant to understanding adaptation to host environment and mechanisms of pathogenicity [5-10]. Staphylococcus simiae was isolated from South American squirrel monkeys in 2000, and is a coagulase-negative bacterium closely related, and indeed possibly the sister group, to S. aureus [11]. Comparison between S. aureus and S. simiae genomes could provide valuable information regarding host adaptation and pathogenesis. Thus, we determined a draft genome sequence of S. simiae type strain CCM 7213T (= LMG 22723T), and included it in comparative genomic analyses with 11 other Staphylococcus species.","divisions":[{"label":"Title","span":{"begin":0,"end":10}}],"tracks":[{"project":"2_test","denotations":[{"id":"22272658-21109164-10678831","span":{"begin":373,"end":374},"obj":"21109164"},{"id":"22272658-20668911-10678831","span":{"begin":373,"end":374},"obj":"20668911"},{"id":"22272658-20011685-10678831","span":{"begin":373,"end":374},"obj":"20011685"},{"id":"22272658-20005777-10678832","span":{"begin":495,"end":496},"obj":"20005777"},{"id":"22272658-17475002-10678833","span":{"begin":755,"end":756},"obj":"17475002"},{"id":"22272658-19304960-10678833","span":{"begin":755,"end":756},"obj":"19304960"},{"id":"22272658-16585510-10678833","span":{"begin":755,"end":756},"obj":"16585510"},{"id":"22272658-19815525-10678833","span":{"begin":755,"end":756},"obj":"19815525"},{"id":"22272658-18700032-10678833","span":{"begin":755,"end":756},"obj":"18700032"},{"id":"22272658-19912661-10678833","span":{"begin":755,"end":756},"obj":"19912661"},{"id":"22272658-16166694-10678834","span":{"begin":950,"end":952},"obj":"16166694"}],"attributes":[{"subj":"22272658-21109164-10678831","pred":"source","obj":"2_test"},{"subj":"22272658-20668911-10678831","pred":"source","obj":"2_test"},{"subj":"22272658-20011685-10678831","pred":"source","obj":"2_test"},{"subj":"22272658-20005777-10678832","pred":"source","obj":"2_test"},{"subj":"22272658-17475002-10678833","pred":"source","obj":"2_test"},{"subj":"22272658-19304960-10678833","pred":"source","obj":"2_test"},{"subj":"22272658-16585510-10678833","pred":"source","obj":"2_test"},{"subj":"22272658-19815525-10678833","pred":"source","obj":"2_test"},{"subj":"22272658-18700032-10678833","pred":"source","obj":"2_test"},{"subj":"22272658-19912661-10678833","pred":"source","obj":"2_test"},{"subj":"22272658-16166694-10678834","pred":"source","obj":"2_test"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"2_test","color":"#ec93d1","default":true}]}]}}