PMC:3317373 / 15431-15825 JSONTXT

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    pmc-enju-pas

    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present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    bionlp-st-ge-2016-test-proteins

    {"project":"bionlp-st-ge-2016-test-proteins","denotations":[{"id":"T7316","span":{"begin":152,"end":156},"obj":"Protein"},{"id":"T7315","span":{"begin":142,"end":146},"obj":"Protein"},{"id":"T7314","span":{"begin":135,"end":140},"obj":"Protein"}],"namespaces":[{"prefix":"_base","uri":"http://bionlp.dbcls.jp/ontology/ge.owl#"}],"text":"The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    bionlp-st-ge-2016-uniprot

    {"project":"bionlp-st-ge-2016-uniprot","denotations":[{"id":"T8372","span":{"begin":135,"end":140},"obj":"http://www.uniprot.org/uniprot/P01584"},{"id":"T8364","span":{"begin":128,"end":133},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T8357","span":{"begin":128,"end":131},"obj":"http://www.uniprot.org/uniprot/P01375"},{"id":"T8380","span":{"begin":142,"end":146},"obj":"http://www.uniprot.org/uniprot/P05231"}],"namespaces":[{"prefix":"_base","uri":"http://www.uniprot.org/uniprot/"}],"text":"The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    GO-MF

    {"project":"GO-MF","denotations":[{"id":"T8282","span":{"begin":142,"end":146},"obj":"http://purl.obolibrary.org/obo/GO_0005138"},{"id":"T8280","span":{"begin":89,"end":96},"obj":"http://purl.obolibrary.org/obo/GO_0005488"},{"id":"T8278","span":{"begin":85,"end":96},"obj":"http://purl.obolibrary.org/obo/GO_0003677"}],"text":"The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    sentences

    {"project":"sentences","denotations":[{"id":"T7215","span":{"begin":181,"end":394},"obj":"Sentence"},{"id":"T7214","span":{"begin":0,"end":180},"obj":"Sentence"},{"id":"T160","span":{"begin":0,"end":180},"obj":"Sentence"},{"id":"T161","span":{"begin":181,"end":394},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    ICD10

    {"project":"ICD10","denotations":[{"id":"T8269","span":{"begin":211,"end":217},"obj":"http://purl.bioontology.org/ontology/ICD10/T14.9"},{"id":"T8268","span":{"begin":44,"end":50},"obj":"http://purl.bioontology.org/ontology/ICD10/T14.9"}],"text":"The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    simple1

    {"project":"simple1","denotations":[{"id":"T8331","span":{"begin":152,"end":156},"obj":"Protein"},{"id":"T8330","span":{"begin":142,"end":146},"obj":"Protein"},{"id":"T8329","span":{"begin":135,"end":140},"obj":"Protein"}],"text":"The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    BioNLP16_DUT

    {"project":"BioNLP16_DUT","denotations":[{"id":"T9918","span":{"begin":110,"end":124},"obj":"Gene_expression"},{"id":"T9917","span":{"begin":51,"end":58},"obj":"Positive_regulation"},{"id":"T9916","span":{"begin":110,"end":124},"obj":"Positive_regulation"},{"id":"T9890","span":{"begin":152,"end":156},"obj":"Protein"},{"id":"T9889","span":{"begin":142,"end":146},"obj":"Protein"},{"id":"T9888","span":{"begin":135,"end":140},"obj":"Protein"}],"relations":[{"id":"R8146","pred":"themeOf","subj":"T9888","obj":"T9918"},{"id":"R8150","pred":"themeOf","subj":"T9889","obj":"T9918"},{"id":"R8152","pred":"themeOf","subj":"T9890","obj":"T9918"},{"id":"R8167","pred":"themeOf","subj":"T9916","obj":"T9917"},{"id":"R8168","pred":"themeOf","subj":"T9916","obj":"T9917"},{"id":"R8169","pred":"themeOf","subj":"T9916","obj":"T9917"},{"id":"R8170","pred":"themeOf","subj":"T9918","obj":"T9917"},{"id":"R8171","pred":"themeOf","subj":"T9918","obj":"T9917"},{"id":"R8172","pred":"themeOf","subj":"T9918","obj":"T9917"},{"id":"R8173","pred":"themeOf","subj":"T9918","obj":"T9916"},{"id":"R8174","pred":"themeOf","subj":"T9918","obj":"T9916"},{"id":"R8175","pred":"themeOf","subj":"T9918","obj":"T9916"}],"text":"The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    BioNLP16_Messiy

    {"project":"BioNLP16_Messiy","denotations":[{"id":"T8473","span":{"begin":110,"end":124},"obj":"Positive_regulation"},{"id":"T8472","span":{"begin":51,"end":58},"obj":"Positive_regulation"},{"id":"T8446","span":{"begin":152,"end":156},"obj":"Protein"},{"id":"T8445","span":{"begin":142,"end":146},"obj":"Protein"},{"id":"T8444","span":{"begin":135,"end":140},"obj":"Protein"}],"relations":[{"id":"R6868","pred":"themeOf","subj":"T8444","obj":"T8473"},{"id":"R6869","pred":"themeOf","subj":"T8445","obj":"T8473"},{"id":"R6870","pred":"themeOf","subj":"T8446","obj":"T8472"},{"id":"R6871","pred":"themeOf","subj":"T8446","obj":"T8473"},{"id":"R6895","pred":"themeOf","subj":"T8473","obj":"T8472"},{"id":"R6896","pred":"themeOf","subj":"T8473","obj":"T8472"},{"id":"R6897","pred":"themeOf","subj":"T8473","obj":"T8472"}],"text":"The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    DLUT931

    {"project":"DLUT931","denotations":[{"id":"T8423","span":{"begin":63,"end":75},"obj":"Positive_regulation"},{"id":"T8422","span":{"begin":51,"end":58},"obj":"Positive_regulation"},{"id":"T8421","span":{"begin":110,"end":124},"obj":"Gene_expression"},{"id":"T8395","span":{"begin":152,"end":156},"obj":"Protein"},{"id":"T8394","span":{"begin":142,"end":146},"obj":"Protein"},{"id":"T8393","span":{"begin":135,"end":140},"obj":"Protein"}],"relations":[{"id":"R6842","pred":"themeOf","subj":"T8421","obj":"T8422"},{"id":"R6843","pred":"themeOf","subj":"T8421","obj":"T8423"},{"id":"R6844","pred":"themeOf","subj":"T8421","obj":"T8422"},{"id":"R6845","pred":"themeOf","subj":"T8421","obj":"T8422"},{"id":"R6846","pred":"themeOf","subj":"T8421","obj":"T8423"},{"id":"R6847","pred":"themeOf","subj":"T8421","obj":"T8423"},{"id":"R6848","pred":"themeOf","subj":"T8423","obj":"T8422"},{"id":"R6849","pred":"themeOf","subj":"T8423","obj":"T8422"},{"id":"R6850","pred":"themeOf","subj":"T8423","obj":"T8422"},{"id":"R6818","pred":"themeOf","subj":"T8393","obj":"T8421"},{"id":"R6819","pred":"themeOf","subj":"T8394","obj":"T8421"},{"id":"R6820","pred":"themeOf","subj":"T8395","obj":"T8421"}],"text":"The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    bionlp-st-ge-2016-test-ihmc

    {"project":"bionlp-st-ge-2016-test-ihmc","denotations":[{"id":"T10096","span":{"begin":203,"end":303},"obj":"Positive_regulation"},{"id":"T10091","span":{"begin":59,"end":105},"obj":"Positive_regulation"},{"id":"T10074","span":{"begin":264,"end":303},"obj":"Gene_expression"},{"id":"T10073","span":{"begin":110,"end":179},"obj":"Gene_expression"},{"id":"T10072","span":{"begin":110,"end":179},"obj":"Gene_expression"},{"id":"T10071","span":{"begin":110,"end":179},"obj":"Positive_regulation"},{"id":"T10036","span":{"begin":355,"end":393},"obj":"Entity"},{"id":"T10014","span":{"begin":275,"end":303},"obj":"Protein"},{"id":"T10009","span":{"begin":142,"end":146},"obj":"Protein"},{"id":"T10008","span":{"begin":135,"end":140},"obj":"Protein"},{"id":"T9990","span":{"begin":160,"end":179},"obj":"Entity"},{"id":"T9974","span":{"begin":128,"end":133},"obj":"Protein"},{"id":"T9967","span":{"begin":79,"end":84},"obj":"Protein"},{"id":"T9965","span":{"begin":152,"end":156},"obj":"Protein"},{"id":"T9942","span":{"begin":242,"end":250},"obj":"Protein"},{"id":"T10070","span":{"begin":110,"end":179},"obj":"Positive_regulation"},{"id":"T10069","span":{"begin":110,"end":179},"obj":"Positive_regulation"},{"id":"T10068","span":{"begin":110,"end":179},"obj":"Positive_regulation"},{"id":"T10067","span":{"begin":110,"end":179},"obj":"Gene_expression"},{"id":"T10066","span":{"begin":110,"end":179},"obj":"Gene_expression"},{"id":"T10050","span":{"begin":330,"end":340},"obj":"Entity"}],"relations":[{"id":"R8196","pred":"themeOf","subj":"T9965","obj":"T10066"},{"id":"R8197","pred":"themeOf","subj":"T9965","obj":"T10071"},{"id":"R8203","pred":"themeOf","subj":"T9974","obj":"T10070"},{"id":"R8204","pred":"themeOf","subj":"T9974","obj":"T10073"},{"id":"R8207","pred":"themeOf","subj":"T10014","obj":"T10074"},{"id":"R8223","pred":"themeOf","subj":"T10008","obj":"T10067"},{"id":"R8224","pred":"themeOf","subj":"T10008","obj":"T10069"},{"id":"R8225","pred":"themeOf","subj":"T10009","obj":"T10068"},{"id":"R8226","pred":"themeOf","subj":"T10009","obj":"T10072"},{"id":"R8238","pred":"themeOf","subj":"T10074","obj":"T10096"}],"text":"The present study demonstrated that scratch injury induced the upregulation of NF-κB DNA binding activity and overexpression of TNF-α, IL-1β, IL-6, and MMP9 in cultured astrocytes. Also we revealed that scratch injury induced higher activity of NF-κB and enhanced expression of proinflammatory cytokines in Nrf2 knockout cultured astrocytes than those in wildtype astrocytes for the first time."}

    bionlp-st-ge-2016-spacy-parsed

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    bionlp-st-ge-2016-test-tees

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    testone

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    test3

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