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PMC:3317373 / 130-1289 JSONTXT

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pmc-enju-pas

Id Subject Object Predicate Lexical cue
T183 687-689 TO denotes to
T182 677-686 VB denotes performed
T181 673-676 VB denotes was
T180 662-672 NN denotes zymography
T179 654-661 NN denotes Gelatin
T178 643-652 VB denotes evaluated
T177 638-642 RB denotes also
T176 633-637 VB denotes were
T175 628-632 NN denotes MMP9
T174 624-627 CC denotes and
T173 622-623 -COMMA- denotes ,
T172 618-622 NN denotes IL-6
T171 616-617 -COMMA- denotes ,
T170 611-616 NN denotes IL-1β
T169 609-610 -COMMA- denotes ,
T168 604-609 NN denotes TNF-α
T167 601-603 IN denotes of
T166 594-600 NN denotes levels
T165 586-593 NN denotes protein
T164 582-585 CC denotes and
T163 577-581 NN denotes mRNA
T162 573-576 DT denotes The
T161 567-571 NN denotes EMSA
T160 564-566 IN denotes by
T159 554-563 VB denotes evaluated
T158 550-553 VB denotes was
T157 544-549 NN denotes NF-κB
T156 541-543 IN denotes of
T155 532-540 NN denotes activity
T154 520-531 JJ denotes DNA-binding
T153 516-519 DT denotes the
T152 511-515 RB denotes Then
T151 504-509 FW denotes vitro
T150 501-503 FW denotes in
T149 494-500 NN denotes injury
T148 484-493 JJ denotes traumatic
T147 480-483 DT denotes the
T146 474-479 VB denotes mimic
T145 471-473 TO denotes to
T144 461-470 VB denotes scratched
T143 456-460 VB denotes were
T142 445-455 NN denotes astrocytes
T141 436-444 VB denotes cultured
T140 428-435 JJ denotes Primary
T139 421-426 FW denotes vitro
T138 418-420 FW denotes in
T137 414-417 NN denotes TBI
T136 411-413 IN denotes of
T135 405-410 NN denotes model
T134 403-404 DT denotes a
T133 400-402 IN denotes in
T132 390-399 NN denotes cytokines
T131 374-389 JJ denotes proinflammatory
T130 371-373 IN denotes of
T129 360-370 NN denotes expression
T128 356-359 CC denotes and
T127 350-355 NN denotes NF-κB
T126 347-349 IN denotes of
T125 336-346 NN denotes activation
T124 332-335 DT denotes the
T123 329-331 IN denotes on
T122 324-328 NN denotes Nrf2
T121 321-323 IN denotes of
T120 311-320 NN denotes influence
T119 307-310 DT denotes the
T118 301-306 VB denotes study
T117 298-300 TO denotes to
T116 293-297 NN denotes mice
T115 284-292 JJ denotes knockout
T114 281-283 CC denotes or
T113 272-280 NN denotes wildtype
T112 267-271 NN denotes Nrf2
T111 260-266 CC denotes either
T110 255-259 IN denotes from
T109 244-254 NN denotes astrocytes
T108 235-243 VB denotes cultured
T107 227-234 JJ denotes primary
T106 222-226 VB denotes used
T105 219-221 PRP denotes we
T104 217-218 -COMMA- denotes ,
T103 212-217 RB denotes Hence
T102 207-210 NN denotes TBI
T101 201-206 IN denotes after
T100 190-200 NN denotes astrocytes
T99 187-189 IN denotes in
T98 181-186 NN denotes NF-κB
T97 177-180 CC denotes and
T96 172-176 NN denotes Nrf2
T95 164-171 IN denotes between
T94 151-163 NN denotes relationship
T93 147-150 DT denotes the
T92 141-146 IN denotes about
T91 135-140 VB denotes known
T90 132-134 VB denotes is
T89 125-131 JJ denotes little
T88 121-124 CC denotes but
T87 119-120 -COMMA- denotes ,
T86 116-119 NN denotes TBI
T85 110-115 IN denotes after
T84 104-109 NN denotes brain
T83 100-103 DT denotes the
T82 97-99 IN denotes in
T81 91-96 NN denotes NF-κB
T80 88-90 IN denotes of
T79 77-87 NN denotes activation
T78 69-76 IN denotes through
T77 61-68 NN denotes process
T76 48-60 JJ denotes inflammatory
T75 39-47 VB denotes enhances
T74 29-38 NN denotes depletion
T73 24-28 NN denotes Nrf2
T72 19-23 IN denotes that
T71 12-18 VB denotes proved
T70 7-11 VB denotes been
T69 3-6 VB denotes has
T68 0-2 PRP denotes It
T254 1148-1158 NN denotes astrocytes
T253 1145-1147 IN denotes in
T252 1135-1144 NN denotes cytokines
T251 1119-1134 JJ denotes proinflammatory
T250 1108-1118 JJ denotes downstream
T249 1104-1107 CC denotes and
T248 1098-1103 NN denotes NF-κB
T247 1095-1097 IN denotes of
T246 1084-1094 NN denotes activation
T245 1076-1083 IN denotes through
T244 1063-1075 NN denotes inflammation
T243 1052-1062 JJ denotes aggressive
T242 1047-1051 RB denotes more
T241 1040-1046 VB denotes induce
T240 1036-1039 MD denotes may
T239 1031-1035 NN denotes Nrf2
T238 1028-1030 IN denotes of
T237 1020-1027 NN denotes absence
T236 1016-1019 DT denotes the
T235 1011-1015 IN denotes that
T234 1003-1010 VB denotes suggest
T233 995-1002 NN denotes results
T232 989-994 DT denotes These
T231 977-987 NN denotes astrocytes
T230 974-976 JJ denotes WT
T229 971-973 IN denotes in
T228 966-970 DT denotes that
T227 961-965 IN denotes than
T226 950-960 NN denotes astrocytes
T225 947-949 NN denotes KO
T224 942-946 NN denotes Nrf2
T223 939-941 IN denotes in
T222 929-938 JJ denotes prominent
T221 924-928 RB denotes more
T220 919-923 RB denotes much
T219 915-918 VB denotes was
T218 906-914 NN denotes tendency
T217 901-905 JJ denotes such
T216 897-900 CC denotes And
T215 887-895 VB denotes elevated
T214 882-886 RB denotes also
T213 877-881 VB denotes were
T212 872-876 NN denotes MMP9
T211 869-871 IN denotes of
T210 860-868 NN denotes activity
T209 856-859 CC denotes and
T208 845-855 NN denotes expression
T207 841-844 DT denotes The
T206 832-839 NN denotes scratch
T205 826-831 IN denotes after
T204 824-825 NN denotes h
T203 821-823 CD denotes 24
T202 818-820 IN denotes at
T201 806-817 VB denotes upregulated
T200 801-805 VB denotes were
T199 795-800 IN denotes above
T198 785-794 VB denotes mentioned
T197 775-784 NN denotes cytokines
T196 759-774 JJ denotes proinflammatory
T195 756-758 IN denotes of
T194 745-755 NN denotes expression
T193 741-744 CC denotes and
T192 735-740 NN denotes NF-κB
T191 732-734 IN denotes of
T190 723-731 NN denotes activity
T189 719-722 DT denotes The
T188 713-717 NN denotes MMP9
T187 710-712 IN denotes of
T186 701-709 NN denotes activity
T185 697-700 DT denotes the
T184 690-696 VB denotes detect
R15 T71 T69 arg2Of proved,has
R16 T71 T70 arg2Of proved,been
R17 T74 T73 arg1Of depletion,Nrf2
R18 T74 T75 arg1Of depletion,enhances
R19 T75 T78 arg1Of enhances,through
R20 T75 T88 arg1Of enhances,but
R21 T77 T75 arg2Of process,enhances
R22 T77 T76 arg1Of process,inflammatory
R23 T79 T78 arg2Of activation,through
R24 T79 T80 arg1Of activation,of
R25 T79 T82 arg1Of activation,in
R26 T81 T80 arg2Of NF-κB,of
R27 T84 T82 arg2Of brain,in
R28 T84 T83 arg1Of brain,the
R29 T84 T85 arg1Of brain,after
R30 T86 T85 arg2Of TBI,after
R31 T88 T68 arg1Of but,It
R32 T88 T69 arg1Of but,has
R33 T88 T70 arg1Of but,been
R34 T88 T71 arg2Of but,proved
R35 T88 T72 arg1Of but,that
R36 T88 T87 arg1Of but,","
R37 T89 T90 arg1Of little,is
R38 T89 T91 arg2Of little,known
R39 T91 T88 arg2Of known,but
R40 T91 T90 arg2Of known,is
R41 T91 T92 arg1Of known,about
R42 T94 T92 arg2Of relationship,about
R43 T94 T93 arg1Of relationship,the
R44 T94 T95 arg1Of relationship,between
R45 T96 T97 arg1Of Nrf2,and
R46 T97 T95 arg2Of and,between
R47 T97 T99 arg1Of and,in
R48 T97 T101 arg1Of and,after
R49 T98 T97 arg2Of NF-κB,and
R50 T100 T99 arg2Of astrocytes,in
R51 T102 T101 arg2Of TBI,after
R52 T105 T106 arg1Of we,used
R53 T106 T103 arg1Of used,Hence
R54 T106 T104 arg1Of used,","
R55 T109 T106 arg2Of astrocytes,used
R56 T109 T107 arg1Of astrocytes,primary
R57 T109 T108 arg2Of astrocytes,cultured
R58 T109 T110 arg1Of astrocytes,from
R59 T109 T117 modOf astrocytes,to
R60 T109 T118 arg1Of astrocytes,study
R61 T113 T112 arg1Of wildtype,Nrf2
R62 T113 T114 arg1Of wildtype,or
R63 T114 T110 arg2Of or,from
R64 T114 T111 arg1Of or,either
R65 T116 T114 arg2Of mice,or
R66 T116 T115 arg1Of mice,knockout
R67 T118 T117 arg1Of study,to
R68 T118 T133 arg1Of study,in
R69 T120 T118 arg2Of influence,study
R70 T120 T119 arg1Of influence,the
R71 T120 T121 arg1Of influence,of
R72 T120 T123 arg1Of influence,on
R73 T122 T121 arg2Of Nrf2,of
R74 T125 T124 arg1Of activation,the
R75 T125 T126 arg1Of activation,of
R76 T125 T128 arg1Of activation,and
R77 T127 T126 arg2Of NF-κB,of
R78 T128 T123 arg2Of and,on
R79 T129 T128 arg2Of expression,and
R80 T129 T130 arg1Of expression,of
R81 T132 T130 arg2Of cytokines,of
R82 T132 T131 arg1Of cytokines,proinflammatory
R83 T135 T133 arg2Of model,in
R84 T135 T134 arg1Of model,a
R85 T135 T136 arg1Of model,of
R86 T135 T139 arg1Of model,vitro
R87 T137 T136 arg2Of TBI,of
R88 T139 T138 arg1Of vitro,in
R89 T142 T140 arg1Of astrocytes,Primary
R90 T142 T141 arg2Of astrocytes,cultured
R91 T142 T143 arg1Of astrocytes,were
R92 T142 T144 arg2Of astrocytes,scratched
R93 T142 T146 arg1Of astrocytes,mimic
R94 T144 T143 arg2Of scratched,were
R95 T146 T144 arg3Of mimic,scratched
R96 T146 T145 arg1Of mimic,to
R97 T146 T151 arg1Of mimic,vitro
R98 T149 T146 arg2Of injury,mimic
R99 T149 T147 arg1Of injury,the
R100 T149 T148 arg1Of injury,traumatic
R101 T151 T150 arg1Of vitro,in
R102 T155 T153 arg1Of activity,the
R103 T155 T154 arg1Of activity,DNA-binding
R104 T155 T156 arg1Of activity,of
R105 T155 T158 arg1Of activity,was
R106 T155 T159 arg2Of activity,evaluated
R107 T157 T156 arg2Of NF-κB,of
R108 T159 T152 arg1Of evaluated,Then
R109 T159 T158 arg2Of evaluated,was
R110 T161 T159 arg1Of EMSA,evaluated
R111 T161 T160 arg2Of EMSA,by
R112 T163 T164 arg1Of mRNA,and
R113 T165 T164 arg2Of protein,and
R114 T166 T162 arg1Of levels,The
R115 T166 T163 arg1Of levels,mRNA
R116 T166 T165 arg1Of levels,protein
R117 T166 T167 arg1Of levels,of
R118 T166 T176 arg1Of levels,were
R119 T166 T178 arg2Of levels,evaluated
R120 T168 T169 arg1Of TNF-α,","
R121 T169 T171 arg1Of ",",","
R122 T170 T169 arg2Of IL-1β,","
R123 T171 T174 arg1Of ",",and
R124 T172 T171 arg2Of IL-6,","
R125 T174 T167 arg2Of and,of
R126 T174 T173 arg1Of and,","
R127 T175 T174 arg2Of MMP9,and
R128 T178 T176 arg2Of evaluated,were
R129 T178 T177 arg1Of evaluated,also
R130 T180 T179 arg1Of zymography,Gelatin
R131 T180 T181 arg1Of zymography,was
R132 T180 T182 arg2Of zymography,performed
R133 T182 T181 arg2Of performed,was
R134 T184 T182 arg3Of detect,performed
R135 T184 T183 arg1Of detect,to
R136 T186 T184 arg2Of activity,detect
R137 T186 T185 arg1Of activity,the
R138 T186 T187 arg1Of activity,of
R139 T188 T187 arg2Of MMP9,of
R140 T190 T189 arg1Of activity,The
R141 T190 T191 arg1Of activity,of
R142 T190 T200 arg1Of activity,were
R143 T190 T201 arg2Of activity,upregulated
R144 T192 T193 arg1Of NF-κB,and
R145 T193 T191 arg2Of and,of
R146 T193 T195 arg1Of and,of
R147 T194 T193 arg2Of expression,and
R148 T197 T195 arg2Of cytokines,of
R149 T197 T196 arg1Of cytokines,proinflammatory
R150 T197 T198 arg2Of cytokines,mentioned
R151 T198 T199 arg1Of mentioned,above
R152 T201 T200 arg2Of upregulated,were
R153 T201 T202 arg1Of upregulated,at
R154 T204 T202 arg2Of h,at
R155 T204 T203 arg1Of h,24
R156 T204 T205 arg1Of h,after
R157 T206 T205 arg2Of scratch,after
R158 T208 T209 arg1Of expression,and
R159 T209 T207 arg1Of and,The
R160 T209 T211 arg1Of and,of
R161 T209 T213 arg1Of and,were
R162 T209 T215 arg2Of and,elevated
R163 T210 T209 arg2Of activity,and
R164 T212 T211 arg2Of MMP9,of
R165 T215 T213 arg2Of elevated,were
R166 T215 T214 arg1Of elevated,also
R167 T218 T217 arg1Of tendency,such
R168 T218 T219 arg1Of tendency,was
R169 T218 T222 arg1Of tendency,prominent
R170 T219 T216 arg1Of was,And
R171 T221 T220 arg1Of more,much
R172 T222 T219 arg2Of prominent,was
R173 T222 T221 arg1Of prominent,more
R174 T222 T223 arg1Of prominent,in
R175 T222 T227 arg1Of prominent,than
R176 T226 T223 arg2Of astrocytes,in
R177 T226 T224 arg1Of astrocytes,Nrf2
R178 T226 T225 arg1Of astrocytes,KO
R179 T228 T227 arg2Of that,than
R180 T228 T229 arg1Of that,in
R181 T231 T229 arg2Of astrocytes,in
R182 T231 T230 arg1Of astrocytes,WT
R183 T233 T232 arg1Of results,These
R184 T233 T234 arg1Of results,suggest
R185 T237 T236 arg1Of absence,the
R186 T237 T238 arg1Of absence,of
R187 T237 T240 arg1Of absence,may
R188 T237 T241 arg1Of absence,induce
R189 T239 T238 arg2Of Nrf2,of
R190 T241 T234 arg2Of induce,suggest
R191 T241 T235 arg1Of induce,that
R192 T241 T240 arg2Of induce,may
R193 T241 T245 arg1Of induce,through
R194 T243 T242 arg1Of aggressive,more
R195 T244 T241 arg2Of inflammation,induce
R196 T244 T243 arg1Of inflammation,aggressive
R197 T246 T245 arg2Of activation,through
R198 T246 T247 arg1Of activation,of
R199 T246 T253 arg1Of activation,in
R200 T248 T249 arg1Of NF-κB,and
R201 T249 T247 arg2Of and,of
R202 T252 T249 arg2Of cytokines,and
R203 T252 T250 arg1Of cytokines,downstream
R204 T252 T251 arg1Of cytokines,proinflammatory
R205 T254 T253 arg2Of astrocytes,in

bionlp-st-ge-2016-test-proteins

Id Subject Object Predicate Lexical cue
T43 611-616 Protein denotes IL-1β
T44 618-622 Protein denotes IL-6
T45 628-632 Protein denotes MMP9
T46 713-717 Protein denotes MMP9
T47 872-876 Protein denotes MMP9

bionlp-st-ge-2016-uniprot

Id Subject Object Predicate Lexical cue
T265 604-609 http://www.uniprot.org/uniprot/P01375 denotes TNF-α
T266 611-616 http://www.uniprot.org/uniprot/P01584 denotes IL-1β
T267 618-622 http://www.uniprot.org/uniprot/P05231 denotes IL-6

UBERON-AE

Id Subject Object Predicate Lexical cue
T23 104-109 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain

GO-BP

Id Subject Object Predicate Lexical cue
T49 1063-1075 http://purl.obolibrary.org/obo/GO_0006954 denotes inflammation
T50 77-96 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T51 336-355 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB
T52 1084-1103 http://purl.obolibrary.org/obo/GO_0051092 denotes activation of NF-κB

GO-MF

Id Subject Object Predicate Lexical cue
T257 520-531 http://purl.obolibrary.org/obo/GO_0003677 denotes DNA-binding
T258 524-531 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T259 618-622 http://purl.obolibrary.org/obo/GO_0005138 denotes IL-6

sentences

Id Subject Object Predicate Lexical cue
T34 989-1159 Sentence denotes These results suggest that the absence of Nrf2 may induce more aggressive inflammation through activation of NF-κB and downstream proinflammatory cytokines in astrocytes.
T33 897-988 Sentence denotes And such tendency was much more prominent in Nrf2 KO astrocytes than that in WT astrocytes.
T32 841-896 Sentence denotes The expression and activity of MMP9 were also elevated.
T31 719-840 Sentence denotes The activity of NF-κB and expression of proinflammatory cytokines mentioned above were upregulated at 24 h after scratch.
T30 654-718 Sentence denotes Gelatin zymography was performed to detect the activity of MMP9.
T29 573-653 Sentence denotes The mRNA and protein levels of TNF-α, IL-1β, IL-6, and MMP9 were also evaluated.
T28 511-572 Sentence denotes Then the DNA-binding activity of NF-κB was evaluated by EMSA.
T27 428-510 Sentence denotes Primary cultured astrocytes were scratched to mimic the traumatic injury in vitro.
T26 212-427 Sentence denotes Hence, we used primary cultured astrocytes from either Nrf2 wildtype or knockout mice to study the influence of Nrf2 on the activation of NF-κB and expression of proinflammatory cytokines in a model of TBI in vitro.
T25 0-211 Sentence denotes It has been proved that Nrf2 depletion enhances inflammatory process through activation of NF-κB in the brain after TBI, but little is known about the relationship between Nrf2 and NF-κB in astrocytes after TBI.
T3 0-211 Sentence denotes It has been proved that Nrf2 depletion enhances inflammatory process through activation of NF-κB in the brain after TBI, but little is known about the relationship between Nrf2 and NF-κB in astrocytes after TBI.
T4 212-427 Sentence denotes Hence, we used primary cultured astrocytes from either Nrf2 wildtype or knockout mice to study the influence of Nrf2 on the activation of NF-κB and expression of proinflammatory cytokines in a model of TBI in vitro.
T5 428-510 Sentence denotes Primary cultured astrocytes were scratched to mimic the traumatic injury in vitro.
T6 511-572 Sentence denotes Then the DNA-binding activity of NF-κB was evaluated by EMSA.
T7 573-653 Sentence denotes The mRNA and protein levels of TNF-α, IL-1β, IL-6, and MMP9 were also evaluated.
T8 654-718 Sentence denotes Gelatin zymography was performed to detect the activity of MMP9.
T9 719-840 Sentence denotes The activity of NF-κB and expression of proinflammatory cytokines mentioned above were upregulated at 24 h after scratch.
T10 841-896 Sentence denotes The expression and activity of MMP9 were also elevated.
T11 897-988 Sentence denotes And such tendency was much more prominent in Nrf2 KO astrocytes than that in WT astrocytes.
T12 989-1159 Sentence denotes These results suggest that the absence of Nrf2 may induce more aggressive inflammation through activation of NF-κB and downstream proinflammatory cytokines in astrocytes.

ICD10

Id Subject Object Predicate Lexical cue
T256 494-500 http://purl.bioontology.org/ontology/ICD10/T14.9 denotes injury

simple1

Id Subject Object Predicate Lexical cue
T264 872-876 Protein denotes MMP9
T263 713-717 Protein denotes MMP9
T260 611-616 Protein denotes IL-1β
T261 618-622 Protein denotes IL-6
T262 628-632 Protein denotes MMP9

BioNLP16_DUT

Id Subject Object Predicate Lexical cue
T555 611-616 Protein denotes IL-1β
T556 618-622 Protein denotes IL-6
T557 628-632 Protein denotes MMP9
T558 713-717 Protein denotes MMP9
T559 872-876 Protein denotes MMP9
T560 887-895 Positive_regulation denotes elevated
T561 845-855 Gene_expression denotes expression
R446 T559 T561 themeOf MMP9,expression
R447 T561 T560 themeOf expression,elevated

BioNLP16_Messiy

Id Subject Object Predicate Lexical cue
T281 845-855 Gene_expression denotes expression
T268 611-616 Protein denotes IL-1β
T269 618-622 Protein denotes IL-6
T270 628-632 Protein denotes MMP9
T271 713-717 Protein denotes MMP9
T272 872-876 Protein denotes MMP9
T273 887-895 Positive_regulation denotes elevated
R206 T281 T273 themeOf expression,elevated
R443 T272 T281 themeOf MMP9,expression

DLUT931

Id Subject Object Predicate Lexical cue
T274 611-616 Protein denotes IL-1β
T275 618-622 Protein denotes IL-6
T276 628-632 Protein denotes MMP9
T277 713-717 Protein denotes MMP9
T278 872-876 Protein denotes MMP9
T279 845-855 Gene_expression denotes expression
T280 887-895 Positive_regulation denotes elevated
R444 T278 T279 themeOf MMP9,expression
R445 T279 T280 themeOf expression,elevated

bionlp-st-ge-2016-test-ihmc

Id Subject Object Predicate Lexical cue
T595 360-417 Gene_expression denotes expression of proinflammatory cytokines in a model of TBI
T594 332-355 Positive_regulation denotes the activation of NF-κB
T593 77-120 Positive_regulation denotes activation of NF-κB in the brain after TBI,
T592 745-794 Gene_expression denotes expression of proinflammatory cytokines mentioned
T591 181-210 Protein denotes NF-κB in astrocytes after TBI
T590 190-200 Entity denotes astrocytes
T589 869-876 Protein denotes of MMP9
T588 227-254 Entity denotes primary cultured astrocytes
T587 1148-1158 Entity denotes astrocytes
T586 371-399 Protein denotes of proinflammatory cytokines
T585 284-297 Protein denotes knockout mice
T584 654-672 Entity denotes Gelatin zymography
T562 824-839 Entity denotes h after scratch
T563 710-717 Protein denotes of MMP9
T564 541-549 Protein denotes of NF-κB
T565 942-960 Protein denotes Nrf2 KO astrocytes
T566 618-622 Protein denotes IL-6
T568 735-740 Protein denotes NF-κB
T569 1084-1103 Protein denotes activation of NF-κB
T570 942-960 Entity denotes Nrf2 KO astrocytes
T571 942-946 Protein denotes Nrf2
T572 974-987 Entity denotes WT astrocytes
T573 628-632 Protein denotes MMP9
T575 347-355 Protein denotes of NF-κB
T576 611-623 Protein denotes IL-1β, IL-6,
T577 428-455 Entity denotes Primary cultured astrocytes
T578 577-581 Protein denotes mRNA
T579 172-176 Protein denotes Nrf2
T580 88-96 Protein denotes of NF-κB
T581 604-609 Protein denotes TNF-α
T582 586-593 Protein denotes protein
T583 756-784 Protein denotes of proinflammatory cytokines
R439 T586 T595 themeOf of proinflammatory cytokines,expression of proinflammatory cytokines in a model of TBI
R448 T575 T594 themeOf of NF-κB,the activation of NF-κB
R449 T580 T593 themeOf of NF-κB,"activation of NF-κB in the brain after TBI,"
R450 T583 T592 themeOf of proinflammatory cytokines,expression of proinflammatory cytokines mentioned

bionlp-st-ge-2016-spacy-parsed

Id Subject Object Predicate Lexical cue
T526 1158-1159 . denotes .
T525 1148-1158 NNS denotes astrocytes
T524 1145-1147 IN denotes in
T523 1135-1144 NNS denotes cytokines
T522 1119-1134 JJ denotes proinflammatory
T521 1108-1118 JJ denotes downstream
T520 1104-1107 CC denotes and
T519 1098-1103 NNP denotes NF-κB
T518 1095-1097 IN denotes of
T517 1084-1094 NN denotes activation
T516 1076-1083 IN denotes through
T515 1063-1075 NN denotes inflammation
T514 1052-1062 JJ denotes aggressive
T513 1047-1051 RBR denotes more
T512 1040-1046 VB denotes induce
T511 1036-1039 MD denotes may
T510 1031-1035 NNP denotes Nrf2
T509 1028-1030 IN denotes of
T508 1020-1027 NN denotes absence
T507 1016-1019 DT denotes the
T506 1011-1015 IN denotes that
T505 1003-1010 VBP denotes suggest
T504 995-1002 NNS denotes results
T503 989-994 DT denotes These
T502 987-988 . denotes .
T501 977-987 NNS denotes astrocytes
T500 974-976 NNP denotes WT
T499 971-973 IN denotes in
T498 966-970 DT denotes that
T497 961-965 IN denotes than
T496 950-960 NNS denotes astrocytes
T495 947-949 NNP denotes KO
T494 942-946 NNP denotes Nrf2
T493 939-941 IN denotes in
T492 929-938 JJ denotes prominent
T491 924-928 JJR denotes more
T490 919-923 RB denotes much
T489 915-918 VBD denotes was
T488 906-914 NN denotes tendency
T487 901-905 JJ denotes such
T486 897-900 CC denotes And
T485 895-896 . denotes .
T484 887-895 VBN denotes elevated
T483 882-886 RB denotes also
T482 877-881 VBD denotes were
T481 872-876 CD denotes MMP9
T480 869-871 IN denotes of
T479 860-868 NN denotes activity
T478 856-859 CC denotes and
T477 845-855 NN denotes expression
T476 841-844 DT denotes The
T475 839-840 . denotes .
T474 832-839 NN denotes scratch
T473 826-831 IN denotes after
T472 824-825 NN denotes h
T471 821-823 CD denotes 24
T470 818-820 IN denotes at
T469 806-817 VBN denotes upregulated
T468 801-805 VBD denotes were
T467 795-800 IN denotes above
T466 785-794 VBN denotes mentioned
T465 775-784 NNS denotes cytokines
T464 759-774 JJ denotes proinflammatory
T463 756-758 IN denotes of
T462 745-755 NN denotes expression
T461 741-744 CC denotes and
T460 735-740 NNP denotes NF-κB
T459 732-734 IN denotes of
T458 723-731 NN denotes activity
T457 719-722 DT denotes The
T456 717-718 . denotes .
T455 713-717 NNP denotes MMP9
T454 710-712 IN denotes of
T453 701-709 NN denotes activity
T452 697-700 DT denotes the
T451 690-696 VB denotes detect
T450 687-689 TO denotes to
T449 677-686 VBN denotes performed
T448 673-676 VBD denotes was
T447 662-672 NN denotes zymography
T446 654-661 NN denotes Gelatin
T445 652-653 . denotes .
T444 643-652 VBN denotes evaluated
T443 638-642 RB denotes also
T442 633-637 VBD denotes were
T441 628-632 NNP denotes MMP9
T440 624-627 CC denotes and
T439 622-623 , denotes ,
T438 618-622 NNP denotes IL-6
T437 616-617 , denotes ,
T436 611-616 NNP denotes IL-1β
T435 609-610 , denotes ,
T434 604-609 NNP denotes TNF-α
T433 601-603 IN denotes of
T432 594-600 NNS denotes levels
T431 586-593 NN denotes protein
T430 582-585 CC denotes and
T429 577-581 NNP denotes mRNA
T428 573-576 DT denotes The
T427 571-572 . denotes .
T426 567-571 NNP denotes EMSA
T425 564-566 IN denotes by
T424 554-563 VBN denotes evaluated
T423 550-553 VBD denotes was
T422 544-549 NN denotes NF-κB
T421 541-543 IN denotes of
T420 532-540 NN denotes activity
T419 520-531 JJ denotes DNA-binding
T418 516-519 DT denotes the
T417 511-515 RB denotes Then
T416 509-510 . denotes .
T415 504-509 NN denotes vitro
T414 501-503 IN denotes in
T413 494-500 NN denotes injury
T412 484-493 JJ denotes traumatic
T411 480-483 DT denotes the
T410 474-479 VB denotes mimic
T409 471-473 TO denotes to
T408 461-470 VBN denotes scratched
T407 456-460 VBD denotes were
T406 445-455 NNS denotes astrocytes
T405 436-444 JJ denotes cultured
T404 428-435 JJ denotes Primary
T403 426-427 . denotes .
T402 421-426 NN denotes vitro
T401 418-420 IN denotes in
T400 414-417 NNP denotes TBI
T399 411-413 IN denotes of
T398 405-410 NN denotes model
T397 403-404 DT denotes a
T396 400-402 IN denotes in
T395 390-399 NNS denotes cytokines
T394 374-389 JJ denotes proinflammatory
T393 371-373 IN denotes of
T392 360-370 NN denotes expression
T391 356-359 CC denotes and
T390 350-355 NNP denotes NF-κB
T389 347-349 IN denotes of
T388 336-346 NN denotes activation
T387 332-335 DT denotes the
T386 329-331 IN denotes on
T385 324-328 NNP denotes Nrf2
T384 321-323 IN denotes of
T383 311-320 NN denotes influence
T382 307-310 DT denotes the
T381 301-306 VB denotes study
T380 298-300 TO denotes to
T379 293-297 NNS denotes mice
T378 284-292 NN denotes knockout
T377 281-283 CC denotes or
T376 272-280 NN denotes wildtype
T375 267-271 JJ denotes Nrf2
T374 260-266 DT denotes either
T373 255-259 IN denotes from
T372 244-254 NNS denotes astrocytes
T371 235-243 JJ denotes cultured
T370 227-234 JJ denotes primary
T369 222-226 VBD denotes used
T368 219-221 PRP denotes we
T367 217-218 , denotes ,
T366 212-217 RB denotes Hence
T365 210-211 . denotes .
T364 207-210 NNP denotes TBI
T363 201-206 IN denotes after
T362 190-200 NNS denotes astrocytes
T361 187-189 IN denotes in
T360 181-186 NNP denotes NF-κB
T359 177-180 CC denotes and
T358 172-176 NNP denotes Nrf2
T357 164-171 IN denotes between
T356 151-163 NN denotes relationship
T355 147-150 DT denotes the
T354 141-146 IN denotes about
T353 135-140 VBN denotes known
T352 132-134 VBZ denotes is
T351 125-131 RB denotes little
T350 121-124 CC denotes but
T349 119-120 , denotes ,
T348 116-119 NNP denotes TBI
T347 110-115 IN denotes after
T346 104-109 NN denotes brain
T345 100-103 DT denotes the
T344 97-99 IN denotes in
T343 91-96 NN denotes NF-κB
T342 88-90 IN denotes of
T341 77-87 NN denotes activation
T340 69-76 IN denotes through
T339 61-68 NN denotes process
T338 48-60 JJ denotes inflammatory
T337 39-47 VBZ denotes enhances
T336 29-38 NN denotes depletion
T335 24-28 JJ denotes Nrf2
T334 19-23 IN denotes that
T333 12-18 VBN denotes proved
T332 7-11 VBN denotes been
T331 3-6 VBZ denotes has
T330 0-2 PRP denotes It
R247 T345 T346 det the,brain
R248 T346 T344 pobj brain,in
R249 T347 T337 prep after,enhances
R250 T348 T347 pobj TBI,after
R251 T349 T337 punct ",",enhances
R252 T350 T337 cc but,enhances
R253 T351 T353 advmod little,known
R254 T352 T353 auxpass is,known
R255 T353 T333 conj known,proved
R256 T354 T353 prep about,known
R257 T355 T356 det the,relationship
R258 T356 T354 pobj relationship,about
R259 T357 T356 prep between,relationship
R260 T358 T357 pobj Nrf2,between
R261 T359 T358 cc and,Nrf2
R262 T360 T358 conj NF-κB,Nrf2
R263 T361 T356 prep in,relationship
R264 T362 T361 pobj astrocytes,in
R265 T363 T356 prep after,relationship
R266 T364 T363 pobj TBI,after
R267 T365 T333 punct .,proved
R268 T366 T369 advmod Hence,used
R269 T367 T369 punct ",",used
R270 T368 T369 nsubj we,used
R271 T369 T369 ROOT used,used
R272 T370 T372 amod primary,astrocytes
R273 T371 T372 amod cultured,astrocytes
R274 T372 T369 dobj astrocytes,used
R275 T373 T372 prep from,astrocytes
R276 T374 T376 preconj either,wildtype
R277 T375 T376 amod Nrf2,wildtype
R278 T376 T373 pobj wildtype,from
R279 T377 T376 cc or,wildtype
R280 T378 T379 compound knockout,mice
R281 T379 T376 conj mice,wildtype
R282 T380 T381 aux to,study
R283 T381 T369 xcomp study,used
R284 T382 T383 det the,influence
R285 T383 T381 dobj influence,study
R286 T384 T383 prep of,influence
R287 T385 T384 pobj Nrf2,of
R288 T386 T383 prep on,influence
R289 T387 T388 det the,activation
R290 T388 T386 pobj activation,on
R291 T389 T388 prep of,activation
R292 T390 T389 pobj NF-κB,of
R293 T391 T388 cc and,activation
R294 T392 T388 conj expression,activation
R295 T393 T388 prep of,activation
R296 T394 T395 amod proinflammatory,cytokines
R297 T395 T393 pobj cytokines,of
R298 T396 T388 prep in,activation
R299 T397 T398 det a,model
R300 T398 T396 pobj model,in
R301 T399 T398 prep of,model
R302 T400 T399 pobj TBI,of
R303 T401 T388 prep in,activation
R304 T402 T401 pobj vitro,in
R305 T403 T369 punct .,used
R306 T404 T406 amod Primary,astrocytes
R307 T405 T406 amod cultured,astrocytes
R308 T406 T408 nsubjpass astrocytes,scratched
R309 T407 T408 auxpass were,scratched
R310 T408 T408 ROOT scratched,scratched
R311 T409 T410 aux to,mimic
R312 T410 T408 advcl mimic,scratched
R313 T411 T413 det the,injury
R314 T412 T413 amod traumatic,injury
R315 T413 T410 dobj injury,mimic
R316 T414 T413 prep in,injury
R317 T415 T414 pobj vitro,in
R318 T416 T408 punct .,scratched
R319 T417 T424 advmod Then,evaluated
R320 T418 T420 det the,activity
R321 T419 T420 amod DNA-binding,activity
R322 T420 T424 nsubjpass activity,evaluated
R323 T421 T420 prep of,activity
R324 T422 T421 pobj NF-κB,of
R325 T423 T424 auxpass was,evaluated
R326 T424 T424 ROOT evaluated,evaluated
R327 T425 T424 agent by,evaluated
R328 T426 T425 pobj EMSA,by
R329 T427 T424 punct .,evaluated
R330 T428 T429 det The,mRNA
R331 T429 T444 nsubjpass mRNA,evaluated
R332 T430 T429 cc and,mRNA
R333 T431 T432 compound protein,levels
R334 T432 T429 conj levels,mRNA
R335 T433 T432 prep of,levels
R349 T447 T449 nsubjpass zymography,performed
R350 T448 T449 auxpass was,performed
R351 T449 T449 ROOT performed,performed
R352 T450 T451 aux to,detect
R353 T451 T449 advcl detect,performed
R354 T452 T453 det the,activity
R355 T453 T451 dobj activity,detect
R356 T454 T453 prep of,activity
R357 T455 T454 pobj MMP9,of
R358 T456 T449 punct .,performed
R359 T457 T458 det The,activity
R360 T458 T469 nsubjpass activity,upregulated
R361 T459 T458 prep of,activity
R362 T460 T459 pobj NF-κB,of
R363 T461 T458 cc and,activity
R364 T462 T458 conj expression,activity
R365 T463 T462 prep of,expression
R366 T464 T465 amod proinflammatory,cytokines
R367 T465 T463 pobj cytokines,of
R368 T466 T465 acl mentioned,cytokines
R369 T467 T466 advmod above,mentioned
R370 T468 T469 auxpass were,upregulated
R371 T469 T469 ROOT upregulated,upregulated
R372 T470 T469 prep at,upregulated
R373 T471 T472 nummod 24,h
R374 T472 T470 pobj h,at
R375 T473 T469 prep after,upregulated
R376 T474 T473 pobj scratch,after
R377 T475 T469 punct .,upregulated
R378 T476 T477 det The,expression
R379 T477 T484 nsubjpass expression,elevated
R380 T478 T477 cc and,expression
R381 T479 T477 conj activity,expression
R382 T480 T477 prep of,expression
R383 T481 T480 pobj MMP9,of
R384 T482 T484 auxpass were,elevated
R385 T483 T484 advmod also,elevated
R386 T484 T484 ROOT elevated,elevated
R387 T485 T484 punct .,elevated
R388 T486 T489 cc And,was
R389 T487 T488 amod such,tendency
R390 T488 T489 nsubj tendency,was
R391 T489 T489 ROOT was,was
R392 T490 T491 advmod much,more
R393 T491 T492 advmod more,prominent
R394 T492 T489 acomp prominent,was
R395 T493 T492 prep in,prominent
R396 T494 T495 compound Nrf2,KO
R397 T495 T496 compound KO,astrocytes
R398 T496 T493 pobj astrocytes,in
R399 T497 T492 prep than,prominent
R400 T498 T497 pobj that,than
R401 T499 T498 prep in,that
R232 T330 T333 nsubjpass It,proved
R233 T331 T333 aux has,proved
R234 T332 T333 auxpass been,proved
R235 T333 T333 ROOT proved,proved
R236 T334 T337 mark that,enhances
R237 T335 T336 amod Nrf2,depletion
R238 T336 T337 nsubj depletion,enhances
R239 T337 T333 ccomp enhances,proved
R240 T338 T339 amod inflammatory,process
R241 T339 T337 dobj process,enhances
R242 T340 T337 prep through,enhances
R243 T341 T340 pobj activation,through
R244 T342 T341 prep of,activation
R245 T343 T342 pobj NF-κB,of
R246 T344 T341 prep in,activation
R336 T434 T433 pobj TNF-α,of
R337 T435 T434 punct ",",TNF-α
R338 T436 T434 conj IL-1β,TNF-α
R339 T437 T436 punct ",",IL-1β
R340 T438 T436 conj IL-6,IL-1β
R341 T439 T438 punct ",",IL-6
R342 T440 T438 cc and,IL-6
R343 T441 T438 conj MMP9,IL-6
R344 T442 T444 auxpass were,evaluated
R345 T443 T444 advmod also,evaluated
R346 T444 T444 ROOT evaluated,evaluated
R347 T445 T444 punct .,evaluated
R348 T446 T447 compound Gelatin,zymography
R402 T500 T501 compound WT,astrocytes
R403 T501 T499 pobj astrocytes,in
R404 T502 T489 punct .,was
R405 T503 T504 det These,results
R406 T504 T505 nsubj results,suggest
R407 T505 T505 ROOT suggest,suggest
R408 T506 T512 mark that,induce
R409 T507 T508 det the,absence
R410 T508 T512 nsubj absence,induce
R411 T509 T508 prep of,absence
R412 T510 T509 pobj Nrf2,of
R413 T511 T512 aux may,induce
R414 T512 T505 ccomp induce,suggest
R415 T513 T514 advmod more,aggressive
R416 T514 T515 amod aggressive,inflammation
R417 T515 T512 dobj inflammation,induce
R418 T516 T512 prep through,induce
R419 T517 T516 pobj activation,through
R420 T518 T517 prep of,activation
R421 T519 T518 pobj NF-κB,of
R422 T520 T517 cc and,activation
R423 T521 T523 amod downstream,cytokines
R424 T522 T523 compound proinflammatory,cytokines
R425 T523 T517 conj cytokines,activation
R426 T524 T512 prep in,induce
R427 T525 T524 pobj astrocytes,in
R428 T526 T505 punct .,suggest

bionlp-st-ge-2016-test-tees

Id Subject Object Predicate Lexical cue
T314 1040-1046 Positive_regulation denotes induce
T313 1084-1094 Positive_regulation denotes activation
T312 1098-1103 Protein denotes NF-κB
T311 1031-1035 Protein denotes Nrf2
T310 942-949 Protein denotes Nrf2 KO
T309 887-895 Positive_regulation denotes elevated
T308 845-855 Gene_expression denotes expression
T307 872-876 Protein denotes MMP9
T306 806-817 Positive_regulation denotes upregulated
T305 735-740 Protein denotes NF-κB
T304 713-717 Protein denotes MMP9
T303 628-632 Protein denotes MMP9
T302 618-622 Protein denotes IL-6
T301 611-616 Protein denotes IL-1β
T300 604-609 Protein denotes TNF-α
T299 544-549 Protein denotes NF-κB
T298 311-320 Regulation denotes influence
T297 336-346 Positive_regulation denotes activation
T296 350-355 Protein denotes NF-κB
T295 324-328 Protein denotes Nrf2
T294 267-280 Protein denotes Nrf2 wildtype
T293 39-47 Positive_regulation denotes enhances
T292 77-87 Positive_regulation denotes activation
T291 181-186 Protein denotes NF-κB
T290 172-176 Protein denotes Nrf2
T289 91-96 Protein denotes NF-κB
T288 24-28 Protein denotes Nrf2
R209 T296 T297 themeOf NF-κB,activation
R210 T297 T298 themeOf activation,influence
R211 T298 T295 Cause influence,Nrf2
R212 T305 T306 themeOf NF-κB,upregulated
R213 T307 T308 themeOf MMP9,expression
R214 T308 T309 themeOf expression,elevated
R215 T312 T313 themeOf NF-κB,activation
R216 T313 T314 themeOf activation,induce
R207 T289 T292 themeOf NF-κB,activation
R208 T292 T293 themeOf activation,enhances

testone

Id Subject Object Predicate Lexical cue
T11 1020-1027 Negative_regulation denotes absence
T10 872-876 Protein denotes MMP9
T9 713-717 Protein denotes MMP9
T8 628-632 Protein denotes MMP9
T7 618-622 Protein denotes IL-6
T6 611-616 Protein denotes IL-1β

test3

Id Subject Object Predicate Lexical cue
T22 1020-1027 Negative_regulation denotes absence
T21 872-876 Protein denotes MMP9
T20 713-717 Protein denotes MMP9
T19 628-632 Protein denotes MMP9
T18 618-622 Protein denotes IL-6
T17 611-616 Protein denotes IL-1β
T16 872-876 Protein denotes MMP9
T15 713-717 Protein denotes MMP9
T14 628-632 Protein denotes MMP9
T13 618-622 Protein denotes IL-6
T12 611-616 Protein denotes IL-1β